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<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDD7</accession>
    <name>W3VDD7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADPH-dependent beta-ketoacyl reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDD7"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="30601" checksum="DD19E84AE7525267" modified="2014-03-19" version="1">MPKDAAPEVMPELGAQRLFSLDGKIALVTGGGTGIGKMIAATYIRNGAKVYIASRKLADLEKVATQLSKLAPSDPEGKKGLCVALQADVGSKAGCDALAEQVKKAESRLDILVNNSGLTWGAPMVDFPEQKGWDKVFDLNVKSQFYLTVALLPLLENGKSNTEHATVLNIASTAAIVPLAEGGLSAPGNGTYSYQPSKAASLHLTKVLANSLAEKFIMVNAICPGVFPSRMTAYGLEENRDLLEGIQPTGRVGTPEDIGGVAMFFASRAGAHCTGTGIVVDGGQSIQFQPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDE3</accession>
    <name>W3VDE3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDE3"/>
    <dbReference type="HOGENOM" id="CLU_102310_0_0_1"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="173" mass="19718" checksum="A405EDF9BA433CEF" modified="2014-03-19" version="1">MLRPTQSLMLRSSLRQLASASNQPIPPGSEMNAVKRTAATILPPVKLYRRLLRAHRKLDADMRAVGDNYIKDEFRRHRLIDNPLQIVGFLSSWKMYLDQLEVQQGQPGGFRGQRLDPQLLEKMSDEQIYQIHDLMTATQEAYSEKAQAHPPHQQRELAEKAAAEAGMSVKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDK5</accession>
    <name>W3VDK5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDK5"/>
    <dbReference type="HOGENOM" id="CLU_1103467_0_0_1"/>
    <dbReference type="OrthoDB" id="5289249at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="1">
        <location>
            <begin position="33"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="222" mass="23257" checksum="A7D67807435677D3" modified="2014-03-19" version="1">MSGEDAFGGPREDLWKTTDGGTIKAHRHIRIDWNASIKKTITIGPSAPEALPPIYDRPAAEDEAATAASCVLKTKASPINATVHVAHESHSQSSSSAGQPVLVSAKTGGVGLISLGIPDYSGSRPLHIVAKSSSGNITILLPSSFSGNLTWSSERGSLKLSHAVQQRFRLDGPRHKHIGTAKIAPSTASGNRADSCTLTSHNGTITVKEYGEESDAKACTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDV7</accession>
    <name>W3VDV7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDV7"/>
    <dbReference type="HOGENOM" id="CLU_280910_0_0_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF14">
        <property type="entry name" value="ZINC FINGER PROTEIN GRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="753"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1009"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="767"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="806"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1028" mass="110224" checksum="A5A54D6C9AA146B1" modified="2014-03-19" version="1">MPARPARELIYRTAAYLSSAKHDPSKKNPSTSAYTALLALAAMSSADAADYGFKRFRVARACVVCRLRKTKCNGEQPCDRCKAHSAECKYDMIETPAPKRISRTGSTSSLPATTAHEAPSDHGSPADTAAEARASKRQKRAMIDQIADRRWGDRQPSRSSSALRKSGYVLHHLELYASIDQDEPTEPDMELHTEDGIRAHDQNTGNMQFYGFTSNFNFQHRLAQTIEALRLREQHQHGAHSRSASSATADPAADKARRSSQLPESMKIWGHQDLIFRQSLSEKSFPTLDGSKDAVGDSTFLPPSIVDRFIENYMTLIQPQLGAVPKRQILKWVKDAKAQGYLSRGFLGVPSMAASGPGSRLHLPQTTPGQSPPMRTNELAALYVVLALGAMMDEGDWVDVHAPVPMTREGAIACATTLFLLAKKRLEEIVENSSIQSARCLLLMSFFSLQWSSPNVAYLYIGYAARMCISIGLHRETFYSPSNPRSAEHRQLWWTCYGIERMISTWFGQASAIRDDDVSARLPQPDNSYDAYLLVYAQIARVCSDMSKLSANPPANAHDVLLASERMEAELLRIRRDAPAELGVGLRDGFARDADDDSDSSDLVVRRYSVTTLWWYLRLLIHSPLVIFALYCRSIGTDIPRSVLDKTHNAARAGQQIIDAISNARSDVPRPGLDNMRFGSFYLDSACTIVLAAILCDPSNQEVAFGYLAAIDRAIKYLEKKERIYADHGTTASLHKARDLVVLARQVVRAAAGQNASSRVNDHSAARNRSAAHASAGNGHTTGTGSTSVGAASSGGSGDLAGRVSQAGNGRLASTFSTSSERGTALGEDGGQDEYDRAQAATPRALGSSMGAENSSTDLLAGASSSSAYRTHAAATGMTPALEATPTPDAGKSFAHERDEWMSYFMSNFDWLEPLNASSAPAQAGVAAHGDAGAMGMSPPSHVPGSFAAGTGSGYGKGYAGMSMGRMGTAGSPAMSSPGSASGPASLSELDIGLLMGGVSVMESIPGANPPLAPESVATTAAADSFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE40</accession>
    <name>W3VE40_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE40"/>
    <dbReference type="HOGENOM" id="CLU_021326_0_0_1"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="3">
        <location>
            <begin position="349"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="740" mass="81547" checksum="51D1E8F4C75BF991" modified="2014-03-19" version="1">MFGVPVQQLPSAWLAAVTSPTCAWSASIAVLLCLVPPARALTVRILCEVYSAVVHRPFVSAPIAFLFSAKDGPLPKSDSLWSRLQAATTLQWRAKHAGLRHERHIDWTQPDQPQEGDMIEAWDRIAEWDSACFHPHKLEQLRRFGDSLADDALARLDRLPAVEPPSTDTLRRIFDEASKQVPGSDQPTECRTFWQSIDRRPPPGAGALGLDWYRSQYNPEEVQGLPHWPRHPSSNQKEPVASIPVWSPSGSECIDAGNGLEELRAEAEIIRRGQDVFYRYAGPILTVLLHFSLAGGFASPRITEVLKQTAYLVPSSASVPGQDMPKSASASLPTIEDLRRVFKVDKERADRTWDRLLETTQFVLDVMEHADSLHPPSSPAATPARATTSSEDQAASSSSPESGGDGWQSAVRVRLLHANVRRRVLKMAERRKASSSPGGQAIYDVEKNGMPINQEDLLGTLCAFSSAPLAMLQKIGITPTAQEREDYIALWRHVGFYMGIEPALLRRAFKDAHTADRTLWCTILHLFSKVEVLDSQAVGGKGSSGPRMQGPTIPVLIACADRPPFHTPLSAHVAIARRLIGKSLADALALPASSAKREVLTDIAFLGMRVPIAFGSIYPRRSWERRRLQLARPLLRRLIVFSFGDKRTKFEMPLHQGAAAAEAAAAAESRPTEGERVNVQTQSRNHQEVPVDKEANLQLVRQWRRLMREMIAVMAASALLVVAGAAAACYRLFASSQSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEJ0</accession>
    <name>W3VEJ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_06057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEJ0"/>
    <dbReference type="HOGENOM" id="CLU_043966_2_1_1"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="255" mass="28166" checksum="5605A26B905A1BA4" modified="2014-03-19" version="1">MAKLKLAMVAAMSLTNGIGKDGGLPWRLKGEMAYFRNLTTHVPDEDKQRGVRNAVIMGRKTWASIPPKFRPLSGRINIVISRTQSAQDLGVDPASKDVRVFASVQDALQFLAGPLSGDAVAIDRVFVIGGAQLYGELLDLDTSIATVDKLLVTRILAPQYDCDAHFAEFRTREQLDADADLAKKVAPAEVGAQLETVLEQHLPQLLEQSRWTQASPQALRDYLGTSVPAALANSPDMVSREDDTWYQYQLWMRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEN6</accession>
    <name>W3VEN6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEN6"/>
    <dbReference type="HOGENOM" id="CLU_041468_1_0_1"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="380" mass="40580" checksum="1331CEA21595A8A2" modified="2014-03-19" version="1">MFYDLNIPWPQPMVSSSSAAAHSQSSKKKSKQNAAALSASTASSSAAATPEPPASPLAALRQKDAEALAQLVLELSELRYSCVAFNHVVQSKYDPAQHPNALAPSRDGRPNPPFPELDPRTQAKGKAKATSTTSSHPVTQLSRLTLVLDEHSMAKTGSGWVTNNATALQSYDLLAVRPTNEAAFQHACLTLSELKPFSIDIISLDFGAQPRLPFFLRRSTVNAALENGVQFEITYAPAIGDDAAKARRNLISGARDLLRVTNGKGVFLSSGAADALALRAPYDVINLGAIFGLNPSAARDAISNNCRSLLLRSQTRKTYRGVVSHPVVIPAISQSDSSNIDLGETNGKKRKSAHLSEPASSLSQAQPDLQPNTKSKKHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEQ4</accession>
    <name>W3VEQ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEQ4"/>
    <dbReference type="HOGENOM" id="CLU_821657_0_0_1"/>
    <dbReference type="OrthoDB" id="3361461at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38069" checksum="3B6D728A559D569C" modified="2014-03-19" version="1">MPEFRGNCHHTRIDLDNTRPLSIPTIPRAATKIDRLEARITMSSKRSNDVAAAVGHATLGKVQMPAEHLQILQQRFESLLSSIVGLKEEIATVPGVDEWPALLHRYTNLLSHAYSLSSSLLSASPHFLPSQLASFNKVLEAEAENSNLYADVGTSSALFGSLMADGLPELSFYDRNNPLPLLLAHPVLPIPDENINFLGALLRTAPEADIIKQESSLVESYDAAKAQTVGRMASEDADVDAQLEQIEDEIAQHDMLALRSLRTWYHVRYAPDEEGNVLNVRERLAPADDADEDAGEEESEDDDSDDDAQTKAQQLEQRHRRKLDQDCWTADAVSAFLRGQPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEV6</accession>
    <name>W3VEV6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEV6"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_0_1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="99"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="482" mass="53141" checksum="CE5246C936F01399" modified="2014-03-19" version="1">MAANRLDNIQGHLSGSNGISQAASSVEQRFRSDQLPASRHRSYLTALPRKDSWTIVLTMGSLSADSSSPALAVWSAVPQAPEDAIFKLTASYKADKYDKKVNLGVGAYRDNNGKPYVLPSVKKAQSDLIADDTVDHEYLNITGLPEFTNAAAKLILGADSPAIAEKRVASVQTISGTGANHLGAVFLQRFYQYQKFGVERQIHISNPTWANHKAIFNTVGIAPVDYPYYDAKTIALDFDGFTSALKNAKNQSVFLLHACAHNPTGVDPTQEQWKQIADIFVEKGHFAFFDCAYQGFASGDLDRDAWAVRHFVSRKSIPLLICQSFAKNAGLYGERVGALHVVSATPDQSAAVFSQLAAIQRSEISNPPAFGARVVKMILTDPALFAQWQKDVQEMAGRIITMRESLFELLTKKFQTPGNWDHILKQIGMFTFLGLNTNQCKRMLEEGHIYLTANSRISMAGLTTNNVEYVASWIDKVVRENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF12</accession>
    <name>W3VF12_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Feruloyl esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF12"/>
    <dbReference type="HOGENOM" id="CLU_758947_0_0_1"/>
    <dbReference type="OrthoDB" id="2543211at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF5">
        <property type="entry name" value="FERULOYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832997" description="Feruloyl esterase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="43094" checksum="F445D1BF0D479970" modified="2014-03-19" version="1">MQQSRNALGPASLLLWVSLVLQLFAQQTLSSVVPVTEDLLRRQSGGAPVPNIPLCVPPLLTSPLTGKYPPSAVTTVQTGKNCNQYGDPPARILSNLESPDGLQDLLQICHGEIVQMTDNTGKPRAMCFYANPKSTKDKPLPLLVWLHPSLVSPSYSFPLTGIDLVRDTQSLNNEDASRLGFSYILPAGRNTEHQYPVPDNVGLGWDNWYRNLDRSSPALNADVSFVDKAISYAKAHVPVDSRRVFMSGWSNGAAMSELYAANTDGIAAAAVYSAPDPYRDSQDPCTQVPYPKFATPVRDVHNYCDLIGICTTGQYYYADLKKRYPALKQSLVVIDTLTAAIKGTDASASCDPVCQGACGVTQGLVAHLRWPATRNTDTFFAFLRSNPLPSSGTWGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF79</accession>
    <name>W3VF79_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF79"/>
    <dbReference type="HOGENOM" id="CLU_042172_0_0_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF64">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="64"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="511" mass="55040" checksum="3CA766C8A9AAE207" modified="2014-03-19" version="1">MTNKTQTASAMVDAKTRDDELPPISTLPDLAAVELAVPSTSPCASLAALVPVAVDADHVPPFSQSAVVLLLNFLLNMTFFIIVPTSAAYANQLGASTWFSGLTIGISTLIAGLFLVPFSKRYNRVYRFPILFSSACILVGEVVYALAGAADTAWLMFVGRVILGAGFVSWMYVKKYMTDAAVVGTHKRTMMAACLVTTQVGGMAVGPFIGGLLSKQVRPMDDEHRIWNGFTASGWLMAGIFGGFFALTWFVFVDPVQLVPNSQLELGALPATQASTQTRAMTERNAKDAADAPGEPTLRSMVRELNGAQKFSVLTMCWFSMVNFLVLGAWEANIPVFGQLRFGWSEYNAGNVIALGGLATMPILFALVFAARHVQDRLILAAGLLFGLLGLSLHMGSLESPAHSAVARLGMLHSLNFGSFFTSWFLVALGYNMLTTVTLSLLSKQVPAKYNGLTSTVIQLSNYSGRISGALWGSTIYQVGQFSIVSLELAVTLIGTFLIGFMWRKMDVQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFG5</accession>
    <name>W3VFG5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFG5"/>
    <dbReference type="HOGENOM" id="CLU_797221_0_0_1"/>
    <dbReference type="OrthoDB" id="2547445at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="392" mass="42721" checksum="51E4D8F97FEA01F1" modified="2014-03-19" version="1">MPPPTFARKTNPAQTFPAFTSLETPYPLLRAPSFPPLHLDTQAYTPWDWLWEDRAGCLATAVVQDPMEAHAQSFGWLAIRNFTFCLSREPDPPNKPLGTQPEGNSLGTSDRRKPRTTGMGDSVVVLYHPEQPQQPIAWCNTLVAFTSTQHMRCHTALPTCQRCDAIRSGQQAGKDGQPAPAAPPAGAQAAGQSAGQGKAQDSDPASHPSPENGARRRLDPPATQDQDDRGLVSLTKRDTSSAPGQNSTPQPASDKTAQPFGTPRSATSQDFLADATLQEAIHEFQDFCENKLTLAVRADCPLRVVRGWLDEPPFDLHRFCSSQQGDVWVHHGPRHPNAGISTQSKDDQGKGSTKQPEPVTGEVRSRNVDPHYERGAFDPNDPIVPWPEDKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFJ9</accession>
    <name>W3VFJ9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFJ9"/>
    <dbReference type="ESTHER" id="psea3-m9m693">
        <property type="family name" value="Pectinacetylesterase-Notum"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536568_0_0_1"/>
    <dbReference type="OrthoDB" id="2015280at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004963">
        <property type="entry name" value="PAE/NOTUM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562">
        <property type="entry name" value="NOTUM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562:SF83">
        <property type="entry name" value="PECTIN ACETYLESTERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03283">
        <property type="entry name" value="PAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="599" mass="63529" checksum="30DD43B3B95D12C1" modified="2014-03-19" version="1">MRIPALTASVLLAELTGTAKPPAHVKTGTEALSDGIVYPDTHIAPAFLPLSGDAAINAYIPSSKPYVAHIEPRYVSGFVAPSGYTYSWVVDGYRLAIDTVGNKNYLTRTTISKDASSTTQAHVNACTQFCEKTPTCAMASVIRFNNFSEGNVVCAVYSATAPKSDAIYTTGPFNGPGQVSASYTFNRKAGRVPGTFTSTVTSSAVTTSSTRSVTTSSGFTTIRTSSSTTSTVASSSTTSPVATTSSTTSTPTSASSTSTTSSSTSSSTGTSTTSSAGAAATATTNTTTAPVYDQWVWVDVPGTQCADGSATGFALNLHAGATELVISYQQGGSCYDYNSCYVQKTAYNIDSGFSNATFWAQNQPNTIKWWFPFARDNQWNPWQKANYAWIPYCTGDWHAGDNTVLYPGAASATNHKGWSNAKLDMAKIKQMVPAPSRVLLAGSSAGAFGAILQYQNAQNIFSGTRVDLLADSGETPKSALARPSQNIQPPRCPTCDDASFDSYIVGLAKANTGSRFASMSWSNDTTIPVNQGVSYDDFSAEVVRLFKQQNAETSNSRNFMVQGSGHMLLWTTQYNAADGYTQATFLNKFKTDDPGWSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGB3</accession>
    <name>W3VGB3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGB3"/>
    <dbReference type="HOGENOM" id="CLU_052998_1_0_1"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="318" mass="34625" checksum="010CF14D96368F45" modified="2014-03-19" version="1">MSSSQPSTGESATAAGVEAPAVNLERKARKEAQKALKAQQAAEKKAAKQAQPAPGSSSSKPKESHRRPQSSGEQLSRALAYILRHGADKEGLSMRPDGYIALDDVLDRPRVKSVNMAEEPGEKRRPALEDIQQIVDTNDKKRFELLFDGTWLVRAVQGHSLSQVVELSHTPLTLTNLHLLKLQDDDDNDDADDLADEIDAQLGLQESKVEVVHGTFADAWQQILASGGLKRMSRNHIHLAKGKFGQKGVVSGMRKSANRLIFVDVRRAIADGFQFALSSNGVVLTPGKGQEGVLPVEYFTRVEDAKGNIVWTPPSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGE9</accession>
    <name>W3VGE9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_06193</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGE9"/>
    <dbReference type="HOGENOM" id="CLU_046006_1_3_1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="14">
        <location>
            <begin position="99"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS59872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="238" mass="26162" checksum="DBA80EBFED1E31ED" modified="2014-03-19" version="1">MPASAGSYLASASSCRALLRATRPPCSQRSLAKLAGAPSLSQGSRPAASATPNRRSHVSAPSELVSLCRSPPSRSAILRAFHSSAPRALPPSSETASYRLNHVMLRVKDPKKSLEFYENVLGMDVIDKHDGGDFTLYFLAYQHQKGVSRGEREAILELTHNHGTENDDSFAYHNGNNEPKGFGHLCVSVDDIHAACDRFEKLGVKFQKRLTDGKMRNIAFILDPDNYWIEIIATNKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGK3</accession>
    <name>W3VGK3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGK3"/>
    <dbReference type="HOGENOM" id="CLU_036531_1_0_1"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="366" mass="40056" checksum="5987392266B9EC2E" modified="2014-03-19" version="1">MSATMSATRTLATGLRALTLSSTGASTSTASSVAVRRASTSSSGASSYERSRVPRLPPVAPLPSRLKPTSPAYFTGRPAYIDTLLELEELTRQTKRALEQAHLIAPNAAPPSLASTGASASRANLWVNTEQLQLVLNTNLKAAQYRQIVSRLSLLARYASLVTHLESRPELHHVLGGDNVIQRFHTTLERFMNENAKTNNLLAEKDADRALWTASERKVDRQGRAYSRGRRKESSAQAWLIRAKPDTLGQILVNNMPIADYFTRTAERETVTWPLKLTSTLGTYNVFALARGGGKSGQAGAIAHAVANAIVAETAHGLEFEQGIKLKKYARDVLAKDGVLKRDPRMVERKKTGLAKARKAFTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGU4</accession>
    <name>W3VGU4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGU4"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="49"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="147"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="245"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="337" mass="35301" checksum="F527BCF9D95CFA6F" modified="2014-03-19" version="1">MSSATASSSSSASASIADAASTAYSAVKDVAPGPRKAAATPTQTAQRKDKPLYSLIAGTTAGAVEGFTTYPIEYTKTVSQFAAKAGEKAPGPITIVRNTIAKDGFIGLYSGCGALVTGNAIKAGVRFLSYDHFKTMLEDENGKLSGPRSLLAGLGAGMMEAVFAVTPSETIKTKLIDDGKRAVPKYPRGLVPGTAAIVREEGIRGIYRGLFPVMLRQGANSAVRFGTYSTLKNFVSGSARPGQSLPGGITFGIGAIAGIVTVYATMPLDVIKTRMQTLEARTKYRNTFNCAAVTLREEGVLAFWRGATPRLARLVLSGGIVFTVYEEIMSVLGAKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGW1</accession>
    <name>W3VGW1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04706</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGW1"/>
    <dbReference type="HOGENOM" id="CLU_004414_0_1_1"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="10">
        <location>
            <begin position="116"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="11">
        <location>
            <begin position="389"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="11">
        <location>
            <begin position="598"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1106" mass="120644" checksum="4F1DA27A80E51988" modified="2014-03-19" version="1">MEEQLIQAVDIASNPLARAGPDVTSQALQFLEHLKTITHESWSVGWSVWSARNAADNGPKYSQNARMFGLMLVDDFLENRISLSSDPAAAVASLQQSAIEYIQNEYVSGNGDGAVPYIKNKFAQVLAVLLLQTYNLPPPYTLLPTLLSMIRAHPTASPSQASSSHIPLNPLTTDLVLRVLHDLSVTLGSDVTLRAVRSKERLQRDAVIRDEIRANHAANIAESVWRVVEEGFNRVNLGEHATDPTTAAGVRGLSFASAVDLTAAATKIVEDYVSWIDINLVVSNETVSLLFNVLHHPIPKLRTAAADALHGIVSKGMKPADKLSLAQALNLPQVITPLESQTRTGQAAQNGQSDRSDSNIEFREHLARLTNGLVLEMSKILEESAAEEATKLAAEALLNSVLPLVLAFLSDEYDDASEQMFSGVNMILAMYKKARRRGAELTGPRAEFLSSLIGVALQKMKFDDEAEWPASSFGAADDDDEEEDEDDAKFLDMRRNLQTIVGAIAAIDDKLFSTSVAQLVLSTFASFEASAAGTGAQLSWQQIELALYVITFYGDVMTTATAAPKVGLSPAMFVQSPEAGSKGRAPKLGNEALAALPLSDLGEMVQKLVQSNVSSFPHPAVQLQFFECLVRYSNFFAARSACVSDALPAFLDWRGVHHEKLGVRKRVNYLLYRFVRDLRAVAAVPFDYVQRLLQGLQDLLVVRAELPEVAPDEDPLEKATGHAGYFDSQLYLFETSGVLISLLNTAPQEQLVLLKAISEPLSEQMRQAVQAFQRNAQDLTSVLQVHHLMLALSSLSKGFPDVNPNSAQPEPQWVGVFKAITEQVLLSIGAMNSFAVVREAARGAFARMVSTCGKAVLPYIPGLIDALLSEVTSQELVDFVNFLSLVVNKYKDDVKPIVDQLFLMLVERIFFFLNQGVTGTDDAVHKSELQKAYMNLLSSMVQSGMEGVFVSDKNAAQLETLLQSVVFYSTNSDAACQRTAFSILHRLVAAWGGSSGAANGAGAGLPGFERFIYETLIGLIFEAPSKDTFDFRDAQAQIVLGEIATLAKTIYAKRGDEAVEYLTQVYFPGIHCPPEMAADFAQNLKTLEAKPFKKYLEAFIVRSRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH69</accession>
    <name>W3VH69_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04782</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 12"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH69"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="358" mass="40816" checksum="B97DC751824D7C5E" modified="2014-03-19" version="1">MADFVKLSIFGTVFEVTTRYVDLQPVGMGAFGLVCSANDQLTNTSVAIKKIMKPFSTPVLSKRTYRELKLLKHIRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVAVDVWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDEVIKTICSENTLRFVQSLPKRERVPFSQKFKNADPMALDLLEKMLVFDPRTRISAAEALAHPYLAPYHDPTDEPEAEEAFDWSFNDADLPVDTWKVMMYSEILDFHNIDNSGQDEGPVPPVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHA4</accession>
    <name>W3VHA4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHA4"/>
    <dbReference type="HOGENOM" id="CLU_1778285_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="146" mass="15324" checksum="5CF1BD8571195477" modified="2014-03-19" version="1">MPAVSLDRGSANPKPDPKHCESKARSKAFSSENTAAAAAREGLSCILAWLHTRANAEASTPHSVGHAQDASSYRNWQRGQRSMMGAARFGRHGGDTAAPRSITAASSMGKSKPSSLIGRPGQIPHLGRAVGKRNTVDGLAISSRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHC1</accession>
    <name>W3VHC1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHC1"/>
    <dbReference type="HOGENOM" id="CLU_681811_0_0_1"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="129"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="296"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="394" mass="42707" checksum="16D4A603CBB3CA79" modified="2014-03-19" version="1">MTMPSLSGLPGSDPSASRASSSLPIRPLVHVANLPSTTTERALRDMFASLGPIQSVKVVASRNSAGLAYGFVEFVDVSSAERAVRTLDGWLCFGIPIKVCWAKQSMHPEAMTVTEPDRSAPTHSNAGNAHLFVGDLSPDVDDSMLYSSFSRLPSLVDVRVMYDAETGKSRGFGFVSFRSKRDAETCIATMQGQWLGGRQIRVNWANQKISQLSIMSATAEYPSSTPHPQYPGAYSQLDPFDSTVTSTASFFPPVADLGLPGLPRRHTTTGPTKFPSGTGAKLHFDQVLSEAPASVSSVYVGNLSPLTTAADLVRVFAPFNRGHSVEARIPPARGYGFVTLATHEYAASAISTLSNQGVFLHSRWLRLGWQKEREKPPLEHRSESLPLQQARHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHD4</accession>
    <name>W3VHD4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHD4"/>
    <dbReference type="HOGENOM" id="CLU_080002_1_0_1"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="228" mass="22500" checksum="AD4E5C69C9ADBB45" modified="2014-03-19" version="1">MSFRGGGRGGGDRGGRGGFSSRGGRGAFGGGGRGGYANAGPPETVQPMGSFLHAVEGEMLCQSTDAKHVPYFNAPIYLENKSQIGKVDEILGPINEVYFTVKMDPGMVATSFKPEDKVFISGEKLLPIERFLPKPKSLTKAPKKKGGARGGAAGGARGRGAPRGRGGFGGGRGGGFSGGRGGGFGGARGGGRGGGFGGGRGGGFLGGRGGAGGRGGGFGGRGRGRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHJ5</accession>
    <name>W3VHJ5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05743</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHJ5"/>
    <dbReference type="HOGENOM" id="CLU_004965_3_2_1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="867"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="914"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="962" mass="106838" checksum="9872B032A46EBC67" modified="2014-03-19" version="1">MSRHSPAAVSKFGTRLGLWRLRMLCSAPKVSSMQAGAASTQPRRPSAQLHVISYTSGRAGKLTKRSPQNSNAGGRNGVFLVDENGQLEVSSPLRAYEAELDPGALARNSPAALRPTFIRRRIETPLTRISRVAALSPSQRCACSDMQVNTSQTSSPSGAARRSRPQSRSRAHHQQGLGQDSDEDATTIQMDEYELDTHPHKRYAQGLDEEDDDHEQGEDALMLGPATAADEEAYEMDRQKSRQRARNGRRHVSTGSISDKYDPDDPMHLVSKAVPEHDDPTLPALTWRALLIGSFFCVIGAAIAQLFFYKSNSPSFSSYFVILISLPMGRWLANRLPERTVRIGKWSAQLNPGPFSIKEHLLVAIIASSGATSAYASDIINIQELFYHQHMNWLSSLTLLITTQVLGFGFAGIVNNLLVKPTSMIWPSTLVTTSLFHTLHDKEAPNTRARLRLFAFAFVGIFMYQFLPALLAPTLSSVAMLCLVDNKVPAFRSLSSGYHGLGFLNLTFDWNAAGMSGPFYQPWWAALNFYAGFAGMMYIVMPVLYWGFNFWDAQSFPEILSAGLYNKEHKKFSVDTLLNKDNTLNASAWSEQKPMLLTPYFALSYGLGFATLTSTVTHVLLWHWKDIKKAATNAVHDDVHNRLMRAYEPVPRRWYATTLALSTSASVMLVVLTPSLQLPVWALLLAIFMGLLFIAPLGILRAVSDTGVGLNIISEFVIGYIMPGNPIGNILFKTMAYMSLNQALDLVNDLKLGHYIKIPPRHMFVAQLWGTMIGCVVNLIVVNVVLDPASGYRAFLDGTVEDPSGQWDGRKVHIFFSASVIWGLVGPAEFFSGAYRKLYLGFLIGAILPFIPYVLHKKYRYKWLPKVAWPIILHSAALPPAVPTNVIMTGFFFSWLSQKHLREKHPAWFEKFNYVLSAALDAGASVNALTIFLLTLTLLKYAPVPHWAANPLQDAEHCKPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHP5</accession>
    <name>W3VHP5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_05039</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224923_0_0_1"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000542">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000652">
        <property type="entry name" value="Related to VPS15-ser/thr protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DH" evidence="12">
        <location>
            <begin position="827"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="14">
        <location>
            <begin position="1243"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1687"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="2910"/>
            <end position="2951"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="3402"/>
            <end position="3435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2029"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2615"/>
            <end position="2645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2666"/>
            <end position="2686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2720"/>
            <end position="2764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2792"/>
            <end position="2819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2876"/>
            <end position="2900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3187"/>
            <end position="3214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3269"/>
            <end position="3296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2616"/>
            <end position="2630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2666"/>
            <end position="2678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2722"/>
            <end position="2738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2749"/>
            <end position="2764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2800"/>
            <end position="2814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2884"/>
            <end position="2897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="3269"/>
            <end position="3280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS61094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="3435" mass="373542" checksum="8EC36759EBB5EF16" modified="2014-03-19" version="1">MSTSQHHDAYGRPYRQASHGSYSHSSYDRQHDQASDPYHTDARTAYGPYDPRYPYGQPEPSQGHAWTAQQSRAAGASVPAYDQPQQQSSYDPADRLDRMHIYDQSTQSAMLQQQQQYYPSRAPSASSKRDPALPSYSHTTEPMRHQDAHTVTYSAAPTTKSYFTGRSEPSDRPVSTASGIISLYTDDTGTPLIDQTSHFASESAPVPPLHQAVPRYESTVSDHNRSAHRPSQRASRPLPVAPAPRPLEHTSLPSPGAAQEKSRTPTGPLSPTFRHRADGVDPYASQQGYFNSVSPPPASSTAWSPPVTPSATQHSTAPSSSSNSGAAPSWSPSASQFGTPSSSYGHRPLPSTATSLDRSFSPPPRDGASASPLSSFRSPSYTQASARNARSPAQARSEHDQRSDAGRGAVSRTPSAKLGHTADSSYDPDSLNATNSDRESLRQRTRSEASDLSVRPSRSYRQPLPPIPGASPNAQGSEYLGHGYPATVHGNQSAAGDAYRARMPSQNSLQHQSSFSHLPASVMRTPSQPRTTASPGDEKRQMADKYSHERVDSLAWEPVYSPRPKVEQALSREAPRVSRVQAPEWSLLSTVALLLRAKVPRGVQIKGSIDYPNSFTGKDVVSTLQELLVSDTVGSRHALVVSGDAAGVRQVALSLAKSLKSQLFFHEVDWGEKELTDDVDEVYTFLEDSLADMGSAPADPDDWTAGLNHNSAFDSSLSFSVGGAAADQARKPANTDLDDLPNGVFTPLTRCYSPLCSPGRASACYSPSCSNSATSPLRLTVTDSDSKAARLGGVLDGGITADQAQKKAWAELVPPELLKNIPQAEIARQNAILETIQKEEEFLADLELLESLFVQGLQKPSDAGDPPPLPIGPERDDFIREVFGNHRELAIHIRALVERLHIRQREENPIIQTIGDLFLSAALDWGDAYTTYLINYPLAISRVKREMSVNPRFKAFVEACRRHPAAHKHPLENFLFRPPARLQRYHLHLESILKKTEDGNNDRDSLQNAIDIINDQCKTAQTGVESAELKVKIREYAYNLSAKRNKHAIDMDLLNPERQLIHQGRVLRKPDAFDFDWTELLAILFDNYFIVTKQKRIAEGPDDDLSNVASSSTTAGARFVLAKRPIPVEMLEVTGLTESSISRSIGLSNFHISREREARDFWPFTISHLGGKIEPIALYAPSKAARDQWKAKLDEAIGLRMAMQDSNRVFDQQVLSDEIFAIPPAISLEPDRPVPGVDPSVFHGRVTCAVPFVTADGRRLVAVGCADGVWIGLRNDPKSLRKVLHLKYVTQCAVLESFGIFVVLADKVLISYSLEALVPTTSSSNSSLRPPQKLSGNRDVLFFNVGVLKDRTLLIYMKKKANESVFRALEPVLNAPRGPEGKSGSGFFGKFGKDSKNSDWFRIYKTFFIPSEAYSIQFLKSKLCIICAKGFEIMNLDSLLPGTIPDFVHANREDLRVQQLQKRVETAKPLGMYKTSDGDFLLCYDAFACYVDRLGEPTRLEQIIEWEGFPKQVAFSGDYVLAFDSRFVEVRDALTGRLVQIMRGNDLHFVSGNSTVTSSSSEAAQLAALDADANPVILTKRERVAGRIPFDFQKVVELSPTGPPAGSSGYAPQFQRSGTVMSNARCAQITSASDNTDVARGHVDPTTSRAGSFDPIAAIHKMGNTHSSATARMAGIGNLVSEVGNDIQYDKGIGSSRFLRAVRARHRLGPIVVKAFVKPDPSMSLKSLVKHIRIERESLADVPNVLTYQKVVETERAGYLIRQWLHSNLYDRISTRPFLSSVEKRWITFQLLHAMSDAHERNIAHGDLKCENILVTTSLMIYVTDFASSFKPTYLPLDDPSDFSFFFDTSGRRTCYIAPERFYAADSKYAPGEMRMDADDQDVSDRLGELKADVLGMGRRSGKVTQAMDVFSLGCVIAELWREGAPTFTLSQLFKYREGIFDLDAMLATIPDDAVRELVRSMVALDPKERKAFKEYLAEGRGSVFPPAVPDFLHEYLVELQRTSPAALQQAGGGVSSVDSAASGSNASATAVSLRSEPSPRQMQRAESDERIEKLYEEWATVVRYFDDDVDRTDTSDPNAGPSGLAARINGVLGRFGLQSSFQQTSEGDTAEDERSGTHELYDVFPMHLCIPGVPMQKATLNSASADTDGTAQLILSVILANLRNCVRPSSKIHALELLVHLSTRWLTDETKLDRVLPFAMSLFNDTSSQVRMAAIRTCVQTLMLVRIVTPSNANIFAEYVMPNIKQLGFDPSTPVRCTFAASIVPLAETAERFLQMAQAMRAEGLFAVESDLNGGFVDDQPSEANYDEQLRTFQALLQELIVTLLTDPSASVKRALLAGIAPLCRFFGMAKTNDVMLSHMITYLNDRNWLLREAFFDIIVDVAEVSGTRSLEEYILPLMTQALSDAEENVVYRVINGLRTMTEKNLLDRERILTLLSTTLGFLCHPNLWLRQAVAGLIAVAATKLEDVDVWAVLYPSLRPLLRADVHEFSETNLLEMAKPPLSRPVFSAALTWASQSSQSAFWKSATEGKEQAGLKNGLATEGVGLLLGKSGREVVSTATGRTEEDDRFRDRLRSLGMEDDDEIKLVALRGIIRRLSRQGSKVHGSKVHVSADWDATSPAAGSGASADATRAHPKATIEPQSLDGITPQTIFFSAKTDTRAATSASEGASAYTGTFRSQDDESFSAQVARRRLQGQRTASEGSLGGPIADMRRRMGAAQIGDSQPSTFSTRLSSLQEEQSEAKHRSHAAPSSPSALSQQAQARLGVGKASPAVASTAFTAIGTMTEASARARKLHAANAQASTRPTPSGSRASTVRGGDAGKLGAAAPIDGSSGTTFTSTYDGNDPYIRAHLEAVYLDSFRDRPELGPKVQAGVARRRGGGWNRSSTLPRVPTSSSSKRRPEGRLIAYFTEHTAAVTCLALSPDHAYFVSGSADGTLKVWDTARLEKNVTSKSRATYAAQKGAITGVIAIEGSHCVASTATDGSLHVWRIEMVQSTSSVPRYGRPKLVSNFQLSTPDEYANCLLSTPDEYANCLVQSSTETASHLILGTSLSRLTILDLRTMQVLQTLRNPVEYGPITCLCVDRKKAWLLVGTLAGVVCLWDLRFGLRLRAWQVAPTQAGVLCRVNQIAIHPSKGRGRWVLVAFERVGQANLEAGTARVEQPEVMVETWDIDRGMRVETFEARIDAEGGETVGRSTKLTPVPEAGAGGDGASDAALTGAAAAIERLLRQTQPPVAGDTDPFARQPDSAASAASCAVKALYVSLDGYSSSTLSATPAPSSTRDETGDAQTEDGGGWLDVGKLTTSEPPAAAGGPGGYMITAGSDARLRFWDLGRPDKSAVFGVAPQLAAAGAGVSEVQSQFTAAAPSAGTTARFVHAMAWQGAGRLKSPLLPAHAAAHAAMARTHTDAVTAVGVLEAPFRAIVAADRSGTIRVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHV2</accession>
    <name>W3VHV2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_05063</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHV2"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_1"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="47"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="162"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="270"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS61115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="424" mass="46075" checksum="82D38612F8F8003B" modified="2014-03-19" version="1">MSLFAKRAVASSSRTITSANKAALAASRAARAYSTPVESNGVSFGLSEDQEAYRDLARKFAREEIIPQARHHDQTMEYPTEILKKGWELGLMNTHIPEKYGGPGLGLVECGLISEELAYGCTGIQTAMEANGLAEAPLLVSASDATKAKYLGRMTEEPLMAAYCVTEPGAGSDVANIATKAEKQGDKWVINGTKMWITNGGKANWYFVLAKSDPSAKAAKSMTGFVVDADTPGIHIGKKEINMGQRCSDTRMITFENVVVPEENVLGKPGDGFKTAMGAFDITRPLVAAGAVGLAQRALEEAAKYAVERKTMGKHIIDHQAVAFMLADMQMNVEAARNLVWKSCWTKDQGQRNSFYASMAKARASEAAGFNVDAAVQIFGGLGFNTESPVEKLYRDARIFRLYEGTSEIQRLIISRHIKEMYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI11</accession>
    <name>W3VI11_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI11"/>
    <dbReference type="HOGENOM" id="CLU_040577_0_0_1"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="440" mass="46568" checksum="00709F031B01DED9" modified="2014-03-19" version="1">MDFDDIGSKLANLTMYDVKSLYRQARNYALNVSEIEAKVDEATNDDPWGASSTLMQEIAQATNNFQDFNEIMPTIYRRFMEKEAREWRQIYKALQLLEYLVKHGSERVVDDARSHLATIKILRNFHYIDEKGKDQGINVRNRAKELAEMLSDVDRIRQERRKARTNKTKYTGGGNGEFVPGSGTGRYGGFGSDSYWAGGGAGAGAGSSSGGGGGGAAARESFEEYDAGDFEETPASRPQPSSSTTRGASSRTTQPPKKEAPKVADLFSFDDDDDQPAAPAVPASATHTSAAASTNDGFGDDFDDFQAAPAAAATAASKAPAAATQPPAASFDFFDTAKPSAPVGAASKPAVGNVMAPSQPAQPAAPAQRPAAATNTSFNFDDLWAASSGKSSAAAGKQKMSMAEMAKNQSSSALFASPSSAASSQPAAQQNKKKDIFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI40</accession>
    <name>W3VI40_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI40"/>
    <dbReference type="HOGENOM" id="CLU_029663_3_1_1"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="555" mass="59390" checksum="36DECC1614A73F61" modified="2014-03-19" version="1">MVSAEAVPLRRIEPAAHASSTHTTIPHRRSLDASTQMVTSRAPAGPRTRQLPREALQKRTSYRLNTAFFLFGLLNNALYVVILTAALELLPQGVPTGLVSFANIFPALIAKAVWPYLLRGRVRYTRRVWSCAALSFVGMLLVSFFPALTMRLLGISLASFSSGLGELTFLQLSTRYAPKHRSGTLAASAAASAGIETNFAGDAVGWFASGTGAAGLVGAAAWWVVRPLGVQTGMAILSILPGFMVLAYLAVLPSIQQLLDANPARAQYAPISTSDEAASPTGEQLQDDDEDEAAALYGAEADAGMSGPKDGDGEGDVKVRLSFAEKMTLLRPMLLRYILPLVTVYFAEYTINQGVAPTLIYPLPTSSSHPLLALVVKKLTDYYPLYQLVYQTFVFLSRSSISIFKLPAIPRHLLWLPAVLQTGLLVLLASESLYAWFRQSIASPLVIVLICIEGLAGGAAYVSVFYSIGVDEQSDSNPIALPSATDDASQAEGGEHAYDQAYAMAKKAQEHEFRIGCVGFGDSLGILAASLISMPLQLGLCNAQVAAGRQLCKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIA7</accession>
    <name>W3VIA7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIA7"/>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="63895" checksum="915D07392329B859" modified="2014-03-19" version="1">MQYKLTTSSLLGDSALGKLAALAQRHAPQTPLGYVVTAIGTSALLFGLLVFALIVRIIYNTTLYHYYVSPLRHMKGPKPKLFIGNMDEFITKPGAVGEIEWSRKYAENGVFRSTFMFGREAVHFMRPKALRQILVEDPYSYPKPSMAWKLLGLIAGYGLLTVEGDTHRKMRKTMNPAFSLTNLIEQFPVYYDKVYPLVDVLRKKIDESSEEHAIIDCDAWVNKALLDIICLTAFGYDADSVNNPDNELASAYHAVTSMQNGQNQARLNLVLNLPFGDTVLDWASDVSGWEWGLNRFGKDSAAQTFFQLLNGMHRIKKVSKQILHKQLHSGERAAQAGQSKAIIDIIEETYLSENDGKPKSLKDAERNMITQVLTFLGAGHETTASGVSWTLWNLATHPEAQDKLRKECKELMDQDERPPYSAVKALTYLDAVINESMRITPPVPRTVRCASKASYIDGVYIPKGTLLPISNRAINMDPEVWGADADEFKPERWFNLPEKYDRTFSMITFIAGAHGCIGRTMSYLEMKATICILVSNFRFEPISKDQSPVMDALITMKPKDGLPLKVFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIX1</accession>
    <name>W3VIX1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 39 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIX1"/>
    <dbReference type="HOGENOM" id="CLU_023231_1_0_1"/>
    <dbReference type="OrthoDB" id="3445803at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833224" evidence="1">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="465" mass="50403" checksum="F59FECEB5FF893D4" modified="2014-03-19" version="1">MLSSATGALVLGLVGLAQGISLGGKGYVDLSVYGSSPAHLGAGILYGLPDDPAFSPDKAPVLPSNLFPGAGINFERAGGAQTPYSGYNGGNVTGYRYRFQSTLQNYQYASARGAQFVLLPHDLWGADAATASTNTYPCDNGDCTAWGTFLDMLISDLKSNDMLNGLHIDIWNEPDGSNFWPRSQDQFLQAYAYAHNKYRAAFGTSVPLQGPTTAEPANSQSTWWQNWASYVKANNVIPDIYAYHQLSGRGSPNCGNDPVVSNDQLNEIKRAYGLPDRPVQINEFAGADEQTPAYTAWFFGRFERTGITGLRANWGSKQGLHDDLARLLIVSNDYQTFNTAGDWHVNNYYTQKQKGLITLAGATGSTCYDLYVTQDRGAGQVHILAGTRGQDGPYPITVSNINSFPAFSGLKSLRALVQEIPYNNAGVVNGPILLFNSSVSVSNNQLFYNLSMNNDSAYTIDLYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ67</accession>
    <name>W3VJ67_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04685</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ67"/>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000085">
        <property type="entry name" value="Probable ATP-binding cassette (ABC) transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="163"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="485"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="798"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="845" mass="90361" checksum="057D79DB4DB0B51A" modified="2014-03-19" version="1">MWSSPAAALGIRACSGSAGLRTAMAGTRSIASRPLLSACPSVLVAARPATLSLLAGKASAPSYSLVRHFSVSLARQDDKVQPPKTATAQPEQSSNDDKRPATSKDATTGSLASRLSARIRTLLHAQLAKSAPKSNDGASPAPTQFPDLRRLFSLAMPQKRNILIALGLLLISSSITLTVPFAIGRLIDFFTSGQNALFGLGFGTVAALMLLIFAVGAGAKAGSNILLELSGVRVVQGIRNQAYRSALRQDVELADKGSGDVVSRLSVDTNIVGESLTSDIGDGLRAGATVLFAGTAMFMISSKLTLLMMAVVPPAAIGAVFYGRYLRDLTHKTQDAVGNMTRLAEERLSPPAFRTLTAFNTQRQELRRFDERIGAIVELQTKEAYASGLFYAGTGFVGNCAILTLLTYGGHLVSRGEISVGDLTSLLMYTAYLGGGMVSLTSFFASLMKGLGAGARVFELIDRPATVELGKGETLQLDTAVRGKVRFEDVHFTYPSRPQQPILRGVTLDIEPGQSYALVGGSGAGKSSVHSLLLRFYDPTQGRILLAGKDLASYRPESVRKHLAFVPQEPILFDGTLEDNIKYGTDSATREEVAEAARLAGCEAFIADMPRGLDTVIGARQLSGGQRQRIAIARALVRKPAILLLDEATSALDSASELMVNRAIERIIAEGKITVWIVAHRLSTIRSANNIQVLENGRIVEQGTFQQLDSPGSRFRKLMAAQLDATDHTDHAAPGGAEISDAQLDKLHRLAALIPPTEAAEREALKRDLAGIVHLVETIHRTPGKAVDARPLVAHDAQWNTSLSTSEGKEGERKEGEGTQTLERDQLLERAGDRQYAGYFVVDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJB9</accession>
    <name>W3VJB9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJB9"/>
    <dbReference type="HOGENOM" id="CLU_1917965_0_0_1"/>
    <dbReference type="OrthoDB" id="10319989at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="132" mass="14832" checksum="08A279217512781B" modified="2014-03-19" version="1">MQAFVRCANLKAGGTAGGCALRTSSHVYLSFVLGPGGEGVVYITLKGSESLTMTTDEIPTLPTIEVRWSVPNEDVVSWLADLHEDSRVGYVDGWHQDRDYHEITVRYHVDKPLGEFIDQIKQIPWYVDHKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJV7</accession>
    <name>W3VJV7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJV7"/>
    <dbReference type="HOGENOM" id="CLU_473362_0_0_1"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="622" mass="66356" checksum="19F6D91EF120D874" modified="2014-03-19" version="1">MASPEYTLPAYYRDGVVTFPAYVSLPPSARPDLQACLAAHQTPSVKCITLSADIRSPRSQSWNTPTYKQQIALRWGISVDRIRALSISIDDQFVLIEDHDDWHDWARATFAWIGRANHRHDPDAPKTVEPIHIKVLIDTPAQVQLSTPRPSQSVSRASPTATSSTSTSAAGAQHGDVASSAGTPSQHTDELTLMRSTSPALSSSHSVSLPSMPSAPRPQTDTASTPAPQQQTFNAASTSAAALANDIAGSVLQALQPVSRDLPVVLSSLILSAIPQALNSIHSVSGGIHPAQGTQSAQASPAPSPSAASSSTAPPAPTRPVDTTLQEEDATSVSAPAQQRQSLIEGMLDELARVRAQPAPNAASQATPSPSDAAQEPAAESTMSAELGHAFAEMLSQPDAGALAQPERQATDDDETFSIVSTPVSRGNAARSRSRSRSRSRSPRLGVSGVMLTLLTLFTFLIGLVVPVSGNALNPHAPMLARDTPVVGRQTRQLHLCKCTCFQTNSTLVPLYAPADPAKPCATCTRQFCLDQSLDICKGAKLEHTDHDVGTGFEGDVWAKCFERDSYKDQSIITLYLLVLVALVAFAALRTRMEGWYHDYQRLGPQGIYDAVRQSPWRTSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJW6</accession>
    <name>W3VJW6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJW6"/>
    <dbReference type="HOGENOM" id="CLU_008455_0_3_1"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF36">
        <property type="entry name" value="MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="81"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="554" mass="60861" checksum="138A6F5B0F726E66" modified="2014-03-19" version="1">MSRSQDQHDALRGAAASAVPADHHASAGGDLEQLSPGLATTCEPSIRDSEDAQDEDPFLVNFEYQDPADPRTFATWRKIQILFVTMLLEFWVNVISSIYSFGAPEVATEFGISAVAARVPAAVFLFGFAVGPVICAPLSEDYGRVPVMIIGLVVVALFQIGCALANGLATLVVLRFLSGCFGAVAFNSIGTVSDLWDSDNQGWGVNTFALSAEAGATVGPIIGAFVVQDAGWRWTFGVSGIVLAFLTALFALTVPETRAGVLLSRRAKKLRKSQNEPRYYASHDKLRSEHTVTELFKETVGRPILMLFTEPIVFWFALFDGVNYAVIYMFFEAYPLIFVEYGFTIGQQGLTFFGVLIGFVIAYFLFALQIKWFHYAGSKRPGGVPTPEDRLLWGIPGGILFPISLFFFAWTSFPPIPWIVPVIAGALFGISSHSLFLIVSDYTVSSYSIYAASAIAAQSFLREFLSGAFTLITEPMYHNVGYQWATSILAFTGVPLSVIPFLFYKFGPTIRRRSSFAKELQLVEEKERNRRAKLESRATTLTNNAAAEVNLKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK58</accession>
    <name>W3VK58_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK58"/>
    <dbReference type="HOGENOM" id="CLU_047163_0_0_1"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="122"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="376" mass="42377" checksum="4E2D5467FC1C531A" modified="2014-03-19" version="1">MAPIGPQLPGPSQPRSLSQSSSSSSRSPPRRAVAGPQLPANFTRSRSNSVSSDDDIGPSLPSSSSQPDSSGLNEGARLFLEREARRTAAAESARLAAEQAANSRPEWMLVPPSLSNSSLQAVAGDPLNLKSRGFAQSTPRVSARASGSGTAEVDSSWTETPQQRMERMRAQVTGSHPAPADADELERQRTARRDAHIAAQLQDARQSTSLVQQHNDRRKRDMQRQLEDRDDSRKDRRHRDRDSHRSSESRRDRDRDRDRERHRHHRRDRSKSPRGRDEEKRHSRRDERDERDQRHKDRKGSRSSRSGDKEREEKKSRKQREQDDVRAGKAAAPMLWDRDAALSIGGRLMDEKKRGKLMADASALGDRFGSGSRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK64</accession>
    <name>W3VK64_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_05093</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK64"/>
    <dbReference type="HOGENOM" id="CLU_368857_0_0_1"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="98"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="275"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="584"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="724"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS61141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="755" mass="80402" checksum="7580841F837E3347" modified="2014-03-19" version="1">MSLHPRQSLHPGAMNAHVALPNQSVTGQIMELDQAITLTLQEIDQNFATAHQIVTSRILPAVKEYGVASARVWQGAKFWKTFYEVAANVSLTAHVQTESEYDANSQHGDVTRSANDSRENASFTSEDDGRSPRSESGSIIYTDVDASAVSDDRGVDANDAADDSGLEQLPTDRARVASPPRFSNASMAAAARREAAQRKQQKPRDREDQENMFDPAESPFERLRRDITTNLGRDMAESTLDQSSMLASTKGTGVFGNGETERDRAALAQRIENLGSTHAGRGARHVDPDSSNASSLHDLPHFKPSAASAGGRMKTSSTPKKGALLNKVLDSEHKRNKGRLSYTKIQATPRSSKSKSNPFAPPSVRMWDGIVDLRKTPLTSKIKGSRSSKGAAPGSSKHASKHKSGRADDDSEWDSDSSDKDSLGWPAGMSPPVTMQFSVPQSRYAQTPAKEAAKMMVDDLLRSVGASSPAPRAWPKSASRPRAGHDEVPTASSRKQPVSTPLRMSRKEAKQLEKQRGSAKRRNSIPTPPTLTKRGISVAPETRPGASSANVSSAALLMDAGEGLELDAASAGDEAGEVHRRFGGLNLRAAGMLPVDDDEDDDDDDDESSDSESDDGGESMAGSMLSSAAKMSASSNSRLGAGSQQDNSGWTSSTISSFNQPKQAGRSIEDDTLFGVRDPAQARGTTAARGGSAGAQTKPTGAGAGDARGEESFKVWGHVDEMGTVHGGRPLVDRDDTYSAPSPTPLNMNLGATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKE1</accession>
    <name>W3VKE1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKE1"/>
    <dbReference type="HOGENOM" id="CLU_426403_0_0_1"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="182"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="544" mass="58672" checksum="5EE45FF21E19732B" modified="2014-03-19" version="1">MSSLAISDVPWLSKRIKACCRRAKLFSTHELLLAPPLHLQQALRLTPPEVELLLLQVATAAKAPTVSVLDALNGVAPPPLADDLFGEHRDDSSDSHTDDEPIHDDPRLVPPTQGYDGNFPGAHQFVYDSEDDDDDDDDDDDSSTGLNDDDAESTRPLDTHDPTEWHDSEPARTRDALVHGRARNVYTTGSLELDALLSGGLRCSLLTEIVGESASGKTQIAIQACAFAALGLSPLASSTPPPSQEGFDDGVGVCYITSSGERAAHSIVARALQLATCAISNRFHPDANEDDLERAVELGRAQLLRNLHVACVADIEALDHVLRYQLPALTSRTDIGIVVVDNLPALFQDDPVAGDIDSLVHRSRWLVDVADALKRTSAAVVVVNHVSDAFGIDKDLARRFVFDSASRTSRRTDVVADHPAAMEYAAQSAYTSGLLASVPPTLAAAMTTTADSDSPLYTLHPRTAQLGHTWTNLIHTRLLLTRTNGRVKDPDDDHRYTHVRKAAVVLNPAGPSMLDLPASQAHLRFIITPASAVHALAPYTLHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKG6</accession>
    <name>W3VKG6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03606</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKG6"/>
    <dbReference type="HOGENOM" id="CLU_037966_1_0_1"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833051" description="ribonuclease T2" evidence="4">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="277" mass="30074" checksum="063994F902D38E1E" modified="2014-03-19" version="1">MKFAAATLAVLAAAGTVSADNWLDQLGNSFKNKGQEIAACAKASSQLSCNAKYDIPASSSANCCFNGALVDGGKQSGLILSTQFWTSNAPDPANNGPKDSTTIHGFGIPEYTGAQIVDVMAKYDPALKAYYDKYFKDLNGDAPSFLEHEYNKHGTCYTTMRPTCQPKLPWISQADFAVLNYFRQIAHKFAELPTYDILKAAGIVPDANKTYELADVQAALKQAHGATPFVGCNKKGEMNEFWFFNLVRGSVNFGHYEATESTTKSTCPATLKYLPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKN4</accession>
    <name>W3VKN4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">PaG_04389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKN4"/>
    <dbReference type="HOGENOM" id="CLU_011390_0_1_1"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000576">
        <property type="entry name" value="Ribosome biogenesis protein ERB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="276"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="546"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="924" mass="101984" checksum="7CFF9697C7DCEDD8" modified="2014-03-19" version="1">MARPSASTSAAAASNGAAKRKRNVPAPAAKPSSTNTTKTPATAKGKSKAQELHLGESDDQDAAKLDLESDDDDLQAGDASGDESQDGDEFPEIDLEESEGEADSDAEAEQPEQDDDADDESIDLQDSQADDESEQGYNSSDIDNSDFEGDEPEDDLEYDSAEEDDRASAFAARSDASQTSIDEELSRMVSRYASKPDEESGSLSATNKLGIPRNQAAQAFDLRTRNPDGSAKGVFKRSDITGEMKRVYPEIQPEYDSDSSTEDAENRIGNVPLEWYDDMPHIGYDINGRKVMKPATKDELDRFLDTVDGDGEAWFSARDNSTGKDVRLTDEELAIIRKLQNAEIPDDAYDPYEDYVDWFTGEDKVMQTALTGRPEPKSRFVPSKWEHKKVMKIVRAIRDGRIVPGAKAQKDTKPKFYNIWADADENDTRSPWAVMAAPKLALPGHAESYNPPEEYLFNEQERKDWLDADAEDRKQNYLPDKHGSLRHVPAYQNFVQERFERCLDLYLAPRMMRKKLDIHNPENLLPKLPSPKELRPFPTNVSVVYSHPDGSRVRCLSVDPTGNWLVTGGDDGRARLWDVAIGRCTATWDACEGMPKAERSAVHSVAWCPTKNYSLFAVVVNGRVVIIAPPQTQNYAQTQSGPASSKAASSSGATATSTASFLYATAAAATSMPSKPDARAPVAWTRPAESERRSGVAMYLNITATSASNLKTVVWHAKGDYFATVCPDAAAGAAGMLIHQLSKHRSQSPFRKASKGSSVQKIVFHPNKPWVFVATQRYVRVYDLMAQSLVKTLQTGFKWISSLDVHPSGDHVMVGSYDKKLAWFDLDLSARPYKVLKYHAKAIRAVHFSTAWNLVADASDDGTLQLFYAKVHADYGENLTLVPLKVLRSHEVKNGLGVLDVKWHPTQPWCFSAGADGNALLWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL20</accession>
    <name>W3VL20_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkaline ceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL20"/>
    <dbReference type="HOGENOM" id="CLU_063293_3_0_1"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33409" checksum="3E82E4215E311940" modified="2014-03-19" version="1">MSWYRDPHPVASGYWGPIASTLVWCEQKYRWSYYVAEPINTATNAFFIALSLYGFLSCRRQALPLRFALCHLGVALVGFGSAWFHATLLYSTQLLDELPMIYTSALLTYCVFETSPSHLKPRFRILLPWSLFAMVAWITAVYLRNGNPVFHQCAYAAIQILSTLRVIYLLTNTSSPLTSAAGKVRKREITRLYLFGAVIFLTGFAVWNVDNIFCAHLRAARQYVGYPWAVLLEGHGWWHILTGYGAYSLITAGSLLALCYKEEPANFELTQAAFPIVKRLKPYSPPKARRKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLE9</accession>
    <name>W3VLE9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001744_1_0_1"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="3">
        <location>
            <begin position="33"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1543"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1613"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1483"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1543"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1568"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1617"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1632"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1869" mass="206221" checksum="461B2B313D57E174" modified="2014-03-19" version="1">MMASSNAAGQLARKALMEDARQEEAITVNQRALIDKILARYAAEFTVFRELLQNADDAGATHCELRFESQRSSPSSTASQQPSSSTSSSNLLPDFKATLSNWVFRNDGKPFGNDDWSRLRRIAEGNPDPDRIGAFGVGFYSLFSICEEPIVSSADELMGFFWKGDSLFTKRATNTDRQNAPSGRPWTTFFMALREPAPFPDSPMALAKFLATSLTFTTQIKSISLYWDDHLLCKLTKKLALPKPMVMPSHLNANSPGRTMRVRDLESTAVQIDVQALRLVIDAFEREKPKPKLSLTSALGKSSGGGLTSMLQSAFGFGSSSSKEKEKERELQARREAEQAAANDKAKLDTTAALLTSVSASIHLRIATANVAVSADKAFQKEIERSTKKPPPKVTAFHLIFTGKEEYDASFPQDAEDADNSLSASSSAAALDKGARQIFSGLMPRLEDQGHAFIGFRTHQTTGFSGHIAARFIPTVERESLDFVDRYCAQWNSELLSMGGYVARAVYENELGDIGRLWTNTFGDKRPTTDDDQALAKALKDRALHLMRFFTMRTSSPSSRVSSLFLTSFFGAARQNTISLMSTRGVKHSAAVRMPNTLLSDFIKDLAVIPPNHTEDAPDFVREVRSRNLVQDITMDDVFSELSSRALTTAEMVACLRWWTSVAAHPSYDVSLRSKLLNSAMLTIADPKDAAVPEKIQPLSIVRFYLNTSRLPTDVPLPDSCLSYDVSKSFTSNELARVFGWSELTVAAWLKNLVQISVQARRSGSSAISETDLQTSPAFAEKVLLTLSRAWFALPSAQHDDIQQILAETTCIPTRSQMQKPGDAYFANVSLFSDLPIIELPSGAQVKGNLEKVLIALGVRRHVELQMIFTRLVADGGWSHVDLLAYLASIKDSLSELEKDRLKTTAIFPKHGEIGPLKEDGTPRIIRHRARDLYEPTEALKALQLPVLDWTNKPWRPLSDEARFVFDLGLRRYPPMETILEIAATNQDAAVRSKALAFFLEKFHAHYINQYTIFRAEKYAFVPARLPNENKLVLRKPTEVFTNAEAAVMGFAVAGSEINLADLPKLGLRSNPTATQLIARLVNSPTRGEALARKIFEYLATVNEFSLNDFNQLRGAEFIPVRRTKRVEASSDSATGAPPADIMLVAPMNCYFGGSTSDLQFRDVFFYCDFGSVAGAFLKNCGVRNEPSIEEVTERLVSEPQRFYQLAGSADAYLGILRQIATNWDRIRSPLRKQMARSPFLLGSKRIQEGKADSGAQKTVNLMDADDDEQDEEADDAGTLVYALKKPADVVIVDDANSHMLFASSLFYAPHEDLLQEGLYSKLGSPRLSSLVEERYLVEGRVVRDTQRAREIKALVLERTPLFLFEKRQTSRSEIRKDGEWLKSALEVEEIDGAGLRQVRTLRYDRVHEQNVQKCTATASMRGSKLVLHLSSSMEVDFFEVANSLSKYLLTKQRLQEVLLYMTLLSTSLRNLKRRGFHVDKILSQRKAEREAAEARMREERLKAEERAAEDKATEDKMADWRKQVLSIFPDADPRYVDQALRSHSDAHVERTTNDMLSSNYPRRSKETSSVVSPAAATADDESYGAGDVAAGGKGGAGAGGFLSGFRNRFMQAGGRQRSSLAEGTSSITRPGQGGPGALSGGGQSSEDRALGGLAASGGGGAATAPTRDVTPLSSINNNVLQAIRASRPDASSSIKSEARHGQIKEAADTYCDATPETDLKLAGEVAGMKVFLHPSLDAASMLQANASALERLINRVFSPVGSIFGLDPRSMNVFCDTEGPVIAFNRGGAIYLNFRYYLAWHDELVRQGKMADALVSTYFSVAHEIAHNVVAAHNAEHEYYFSAIAEKYVVSLVEYIAKAEADARVLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLJ9</accession>
    <name>W3VLJ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLJ9"/>
    <dbReference type="HOGENOM" id="CLU_271382_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="809"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="929"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1172"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1195" mass="129995" checksum="395169BB12C33F9A" modified="2014-03-19" version="1">MHAVSRPSRARLACWPASAARLLYLDGHLYRSVACSARSARSWAWVWVWVYGKEQKREKARADERLRQSPWLVLGIRNNKLPCSSVGGQRLNSFQPLLPSSSSSSSSSWSTPNPTSGRSAWLCLQPKPLSNSLSGSFKTRFSPYLVPPPPPPSPLSLSPPPFRHGSSITTPHASPLVSTTITLITFFYITSSPRSRLLYYIPFHAHLHRASASAKPRSFQPSPLSIASLSLFRLSVLDIESLLPFIPARSVRASNAYNRRGATLPARLNSSHHPWYHSSHPRASIILDANTTEPPPCHPLALRYTVATEPSSSALPFHLIVLPGPAGYPVRIRIPCTTTTTTTTTTSQTLGLRPRISILSTAFISRTASAGQRPPQPDPFAFRPSQPSSARAPSSASKQNLAPVFILPHHRLPLLSLVLPSAGLSKASQHSAAKATRLGPPASTIPCAWSTHNPPFMLSTPSLAPFRVGPPIPTTSIRVAAMMSTERRASALAPSLNAASPRASNDAAVPRDMQRNAPDASSSAKSPNSPDRKRPRYEPALSRPAQDDMRSRTIDDEDEMDELDESNEIKRVRGESDDAIHDRKPSGTDIASRPSSAAAHHAHWTNRSASAAVESRYQSQHQQHPQPRHRDPPSDSRRYDYDRPMPSRYDGPAASRDDTRHAGGLPGERYAGEHDRDPRDRMPFDAKQEHGSAALRMPPPNSGEPGMGYRNRAVSPPPRLPGFASLEPDMPAHRSRDEASLAAPYSGSPRRSMPFHPPSYASYPPPPHSRTPLMHHPSPTPSTSYGNPPMIHPSLAGLPGAGGGPGGKQQPSFVSKLYSMLEDASISDLISWGASGTVFSVANPAEFSRLVLPNWFKHSNWQSFVRQLNMYGFHKVNHSYQGNPTDELNMYGFHKVNHSYQGNPTDEVQVWEFRHPSFRRGEIALLNDIKRKSSRQKRAGSPRGSIGGADLRADRSGGSSTPSPEVPLATIPGGPDGMRGMGPGAAAVGMPMGPGGHRAGRDFAYGDERMDPHYADRRPDVRGGYGPERGYLAGPADEYGYMRPKMDGPPGGMPNPAGHPAGAGMGPGFAGDSARRGEPYVERAEAMARFEDLSERTDAIIRHASFLESQIRILSDQLADSRAYTVQVVRDEMVQMLDRLERALTAPAQPGTDPTARMLDAVRAQLAFYMRGPSGPADRGAKQVQPPAAPKRPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLN1</accession>
    <name>W3VLN1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pheromone receptor a1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLN1"/>
    <dbReference type="HOGENOM" id="CLU_027592_0_0_1"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004933">
        <property type="term" value="F:mating-type a-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001546">
        <property type="entry name" value="GPCR_Pheromne_A_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00900">
        <property type="entry name" value="PHEROMONEAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="311" mass="34462" checksum="5791BC768F70ACA3" modified="2014-03-19" version="1">MLDHLTPFFALAAAALVLLPLPYHIKSRNVGTLALSIWLFIGNIDGAINSMVWWHSTSNKAAFFCELMYIAIPACNLVIARKLESIASTRQVHATASDQRRSVIFELMITVGAPLVYVAFMIVNQTNRFGILEEAGCWPFLKLSWAWVVLVAAPVIVVSSISVIYSVLAFRWFWIRRRQFQAVLASSASTINQSRYVRLLALTAVDILLFFPIYLGTTAAEIRSAIVKPYGSWSQVHEDFGIIPEYPAVLIEAQGLGPSIIISKIVCPVSGVICFVLFGLGQEARQGYKATVLRALIALKLRKPPKRPTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLT3</accession>
    <name>W3VLT3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLT3"/>
    <dbReference type="HOGENOM" id="CLU_1262242_0_0_1"/>
    <dbReference type="OrthoDB" id="3353671at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833202" evidence="1">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="220" mass="23329" checksum="844695E08592565B" modified="2014-03-19" version="1">MKFTSASIVVVASVLASVSATPLAFNADDDTISVPIQVPFSSTPRVLTLPNWFHSSGDDGDICPQLPVQCVRDGKVVGDLGPQDFCRQGVSCKMCHPKKKSLDCNTKYIKECATQCQARGPLGGKLAAVQDAIERASHAVGGDDDEGDICPDMKVSCRNADGKTVGSIGKKPFCRDGLTCGQCHQTENSVECNAKFIKDCKAQCEATGPLGGTNVFVHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLW5</accession>
    <name>W3VLW5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLW5"/>
    <dbReference type="HOGENOM" id="CLU_645563_0_0_1"/>
    <dbReference type="OrthoDB" id="10489940at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="458" mass="52809" checksum="94BDD587D666E12E" modified="2014-03-19" version="1">MPLPHDNLHRQRLHIRPHPHPHRHRSKDAPLAPDHRTSSGKSASVQPPLASPRMPHNPSHTQRRRNRHQAGAAATPHLRHQQQQRRQQQQTEPRARCTNCLVEYPLTRRFFLRVDCKRDADRRTCLPCRTGAIVDETELRLLRDEHQEDHGDDVILPEDLADDERLHRDFEDLGAEERRSKLHASRQFGGLVIKHLSATKLAESRLRFRRRVRPASELMLEREILRFRWLADHLPLMSQDDRLKREQRLVQIRPVNIADMQLEPDLLPHAQFLLSLDLSDTSHSDNIDDELERATELLALMRLPERDAIEQAQLIRQRQLVSTHNRNHQRHQRQVAHQLAQQDGDQLAQIFQRGLALTDDDDRRSSEPAKAPPTFTAVANLTAVKAELAATATSLPPATSVSARTGADSPPTPSPSPRATKRPRNQRETPVDPRLEMFERRRQLLRLHNESTQTPKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM49</accession>
    <name>W3VM49_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM49"/>
    <dbReference type="HOGENOM" id="CLU_847655_0_0_1"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="144"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="328" mass="37040" checksum="07A6968FA49D641C" modified="2014-03-19" version="1">MASGGPVRNFLAATPPSSHSEASHSWQQRFAARRSPAPSENGKSGGARRHSQRPGLDRRRRTLQLRAHGSAAHPSTTRSATAHNTRTEAHKLVGIVYPTARSIPTGTEQDTMLGRTNVLVLLCTLLLAVRSTAALYFYLEPDTPKCFLEELPNDTVVVGHYMTEEWDTTLQRFVVKDDMGIHISVREVRDDHVVTSSRGPPEGKFAFTSHEAGDHRICMLAKFDGRPAVQVRMHLDIVIGDAKPDNSHKDKAHVTDLAQRVRDLNALLRDIRKEQQYQREREAQFRDLSEVTNSRAMWWSSLQLITLLGACVWQLRHLRGFFEDKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM64</accession>
    <name>W3VM64_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_03303</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM64"/>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="114"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS62659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="711" mass="79868" checksum="7F61D5DD74EA4272" modified="2014-03-19" version="1">MRPCAIKQRDVAPVQTFAKAAAKCSAEARIYGQCVTANYENIERNMCSKEFLAFKAVRRCQTALWRAFNLLDLAARPSTTCRGFLNMTQGSAGTSLAASVHTDSDVKASAVRPRRTMTRSQLAQRISQGETLVLHRRKIYKLDRWLANHPGGELAILHFVGRDATDEIEAYHSELTISRLMSRFVVAHLDEADWDIYTPLVPPVQLGYRKGKLDHPHAQVGMWRHRNTPAASAGSSDTDGSSDESAEEALVHSLVVGSTAKRSDAADKNERASLASSTLVVDRPHCFPLPVDLLEPPPNPDGIDAEREKRISEAYRQLHQQVKDAGLYALRPAGYAREMARYLALGSIAYAFWARGQAQLQLDSDSAGTLLRASTASFLLSSFFLGLFWHQLTFSAHDSGHSGITHSWQWDRIIGTTIADFIGGLSIGWWCDNHDVHHLVTNHPEHDPDIQHMPFFAISPQFVLAGQTTVINADNAALTGQEQVKPARPLGLWSSYYRRLLEFDAPSRFFLQHQHKLYYIVMAFGRFNLYANSYGFLASKARRDRWWALELVGLATFWTWYAYGLLGSLPTWPVRIAYLVISHVVTSPLHIQIVLSHFAQSCDDLGLSESFASRQIRTTMDVDCPPWLDFVHGGLHMQVSHHLFPRVPRHNLRELRDRFVVPFAKEWGLQYHEYSFTKGNGRVLATLKKVADQVHILSKVAEASAKGELQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMM0</accession>
    <name>W3VMM0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMM0"/>
    <dbReference type="HOGENOM" id="CLU_980698_0_0_1"/>
    <dbReference type="OrthoDB" id="5554402at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019419">
        <property type="entry name" value="AIM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28177">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28177:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10315">
        <property type="entry name" value="Aim19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="289" mass="30607" checksum="CB9366155CF8EFA6" modified="2014-03-19" version="1">MHVAADPFCRTSFQPPFSKIHMASTMSLAPANDGWLQRNVRVLGSYASTSTPSYALSALFALSTPFGFASPAQAAAEAAAKQQHQQQLARASEAAASRGSSSLVARLVANVQSQRSAPSLAPVRTLPPFWQLAFFAAAFGTGGYMIDEGDHLNGSGVVTAWSLTYLLFKTVPVARQLPRNPLAMSLSAAVLALGLGVHGSHYFDQTSWKGNVPSLGAQELKTDGTVKRAVETRPTSIFASTQPPQPIRGTARDHIARKSGGGSNNNDLARTAAFRFRRGDTPSTPALEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMN1</accession>
    <name>W3VMN1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMN1"/>
    <dbReference type="HOGENOM" id="CLU_033999_0_0_1"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="379"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="412"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="526" mass="58394" checksum="6A1B42ABE14167D3" modified="2014-03-19" version="1">MKIKALSRSLDVHAPARQGDPAPLSRNLDPALHPFDKPREYTRAVNAAKLDRLFAKPFVGALEGHIDGIYSIAKDTNRLNVVASGSGDGEIRLWDLARQKPIYVYPRAHSGIIQSICISPLTFMSPSGNSSVGRRMLSCSTDRTVKVWDADPRPDGLGQGTFNAMEDDDDDDDNDDMELTTGGSLRRGGLLSTRDKDVPPSEPLTVYSGKTAFNSLTHHATSAVFASASSNIQTWDLERGGSSDPLLSMTWGPDAINVVRFNLSEREVLASAGSDRGIVLYDLRSGKPLTKMIMQMRANDIAWHPTEPTVFAVASEDHNVYTFDMRHLNSATQVYKDHVAAVMSVDFSPTGTELVSGSYDRTLRIWEYGKGNHSRDVYHTKRMQRIFSTSFSMDARFVLSGSDDGNLRIWKARASEKLGMLSGKEMASREYSESLRKKWSGVGEVSKIEKQRHVPKAIKQAQRLKTTMIDARKNKEENRRKHSKVSSARGESEMVHSADPTIFESFQAGEKKPKAARKEAILSQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMT4</accession>
    <name>W3VMT4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMT4"/>
    <dbReference type="HOGENOM" id="CLU_055321_0_0_1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="385" mass="41509" checksum="D73390D66C16306A" modified="2014-03-19" version="1">MASTTNQAHAGSASTTILLFRHALGRIMATRIIATGGHSGLGFEALKTLLASPALRTPCSLTLLVRDPTASRVVQARDRLVAQYRTASRASCTLDLQIKPLDLASLSSVRQAASALQHQLADSAEGTDILLLNAAVAKSSRETVVDTDKVSSTVEYPTDGMVDANGRVEETACVNHVAHLVLVSMLAPTIAKNARNGRHTRIVFTGSALHRSLKDIADLDSFFAASSTGETKAWTLRETYAASKFLQMLGVRALRRRLEEDFEKRRVPRGRVEVVVVQPGFVPQTQLCRESGLMTRLAMSYILPWAPFATSLEDAGTYIANACTIDLAPPQTEEQADGFHSSTGAVVQSALLEVHAKGQRFGTLDARTADVQLQDKWWPAACDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMU8</accession>
    <name>W3VMU8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003237_0_0_1"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="296"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1308"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1566"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1338"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1703" mass="181268" checksum="0778011820C11D0F" modified="2014-03-19" version="1">MFAPPSPHMGNRPASAAAHHGYAHPQIYDLPSSPMPQEHRLQRSSSFSWKPELGLPPPPSQIDALGDSIQHALVPHRPASRARSVSPATRVPSRYDLGFGGLEDPTEHRDRTQDHMNMVTKHPKVKVDIVLSSNVFEAGGTLSGKVELTCTTSQRLRLGQIAIELEAVEQLTSRDHAATQLFLYNRTMFQGDDLPPSNAVLPAAPINGYWTARKGRTTFPFSFRLPSSAPSCVTFAGNASLRYGLKATAQTWYNDDKMIVTARREAFVLEKWSDVHNPRFYEPVDVVGDTRLFMGGNGAVWLEAGVTEQLFWGGGQMLVRCGIKNNTKRHLSGIKIALARRLIFPVGSPEGVHESAEKMSLEPRITEIVHDQIFKGRDYEFAPNAESVCTAAVDIPRDLRTIRKTRLFEVRTYALVSLLLGSFAKDLTIEIPIYVAHTASGQPPAREGLDDLHNALPVHSLPQRPHSSMGHSHHHHGHHHHAHGAPVHHVHGAIPQMQSGMLEVERLAAERGWSPAPMLNHHNQAGPSVRPASTAPGMIQLPAQAQPFTLGPDGHVQWNPTANSWNASRLIAPADAGHTIQRSMSAAPDVFHNMPPASPLLQGHGGQTAWALPQRSMSVSPGPAQHVQPPAFGHAPQPSGVPSPQFAPTVDNGPSLSAPAPFGGAQPSQPVYQAPIRETLPPMPEPQSITSANLAQFATPPMQSLPSGFPAGGASPIAGLATIDEDGESQAGTVKTLQKLPTMGKNGGGGGKGNSVSRNNIAQFEAMAEAEEDQEEVKRQMIAMGMQPDEDAFSAPTQNPPGIAADVRAADGYSEAVAANSAMSTNSRVTVDTAQTSSAASQRPRASDIFQDVGHREVSAEKERSAPVVTMASVEPSATVVERTQEPSADSQMRKTGESRVSEMRRSSITSLRRSSSSQGFGLEALETKLARSTTPKIGSSSQSTVVMANVGRTDSTSSPLASPIVRQEEGSRSRKNSALRSAALAREEAERKSVEQQARAAEERARQLEAEKASRAAAAIAAAESEAAAAERAAAEREAKRIRQAEQQRQERERLAEEARRQHELRKLEEARAQEEAQRVAREEQLERERQAEMSASMHRSDGGSSELTVKPETGAIESRRLGNIGAVRSPSSTTSLERIQAAIAPAPSSIAPSVPSKTTRPTFGAPSRTSDRDRVVLKREAVHRIDGWLSNAASPNASHMNTPGTPSASVLSVLAKDEPRASASREDERRSSYSYRSPSQVINPLWEGKAAGSRSAHRSIPASQTMADLVSTKTSLASQKAAAEDDEAVPQLSAELRALVDGSEIRSAHRTSTALKDNPISRRLSGIGSTQKPSEADAATASAVSSTEGAKRERHISMPSWPRPGTLNLDAARNAGQGSAAVSSSERRLSRNPEAREVAIPSRVEKTLAAPISGASASDKQPSYDARSARGGKGGRVASVAQLWSKIAGDDEPDAADGERGSLAAPQGDYGPRSASPSSASTVKPKARRLSSASGGAPALDFSKKAATPSASVGVTAIVATFGAASSASKPQSLKSFTAPQFLNTSVSKPVFAKVGAQPAPNSAAEAAATAASKPEKRPLPKPVLEPGAVPAPTLVRPTAMRASKAPAAERSSRRISTQLLSTFEKEKTPKLEPAEVASVRDMMSKVAVDSTILGALQANDVHDGATLRYADGTEIKMSGRGTTKAIGENKLKSLRAVWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMW7</accession>
    <name>W3VMW7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMW7"/>
    <dbReference type="HOGENOM" id="CLU_043312_0_0_1"/>
    <dbReference type="OrthoDB" id="5390558at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="296"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="492" mass="52226" checksum="90CC23DF628A86EC" modified="2014-03-19" version="1">MRAKEGGGVGRHGARPPPFPALQAGLWTPHRDRSRATFSLLYTRSFVGVIASPPSFYVGQLTPQFTDQHPASVILSPYHLRLHQTALAVPLLLEDMRPASARRPRIFATKVFRHRSVRSYDILLASHMSKTSSGLGGARHAEFLLGSLTRTGVRPLPPPDDHSNSIVAKAGWLASEDRHCKSGQTRDFLAASVAPSSSLLANSINPFAILGDDGEDVAAPKAAPKAAAPAAAAQPQRNIPGAGNQRRGPAKNSAPRAPAADAAEGEQQKDARSGRARNGESRGRGGRGGRGRGAPRGRAFDRHSQTDRVDSQKQVAQGWGGEDGEKELDAEQKAEADAKAEGAYSAAAAPAAEAEKVPEEEEDKTMTLDQYLAAQAGKKLNIESKAPREVASDESAWSKLTKHQKEEADYFASTKTQKAKTRTQKEGKQVLEIEQTFNQPAVQRGGRGGARGGSRGAPRGERGAPRGRGGRGGRGNSASVNLADKNAFPSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMY5</accession>
    <name>W3VMY5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02698</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMY5"/>
    <dbReference type="HOGENOM" id="CLU_280619_0_0_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1119" mass="121365" checksum="6B4F3FD635374593" modified="2014-03-19" version="1">MIPGSLATARLSRGSLSGIGRLALRVPAAARCYTAGSLKINADRMMKTLHETCEWGAAHRYGDGPFETGMARLTLDEDDATARRWLWKEAEKLGCSVDVDEMGNMFMIRKGKRDGKPTAMGSHLDTQPTGGRYDGILGVMAGLEALRTMNDHKVETEYPVALVNWTNEEGARFPQSIVGSGVWCHDVPLEKAWNLQDVKDSSLTMKSELAKIGFLGSTRCSHEATPLAAHFELHIEQGPILEATGKRVGIVQGGQAYKWFDINVRGRECHTGSTPFDTRSDAMLCASRIIVESNRIAKQHKGLASTGILRLSPGSVNTCPGHVFFTLDVRHPSTHKLAALCSEIEAAAQHIAAEESEKGCSLEWVETFDSPAITFHRDCIDSVRKAVEANYGSDAGVDIYSGAGHDTCSTSKVCPSSMVFITSKDGVSHNPREYSSPEDCATGAQVLMDAALLHGNVEAMVGSRGKKCCCCYPGMVARGALVTSTISARLLSILYPSPILLKPLDSPSIMAAPYTDTGVKPDDFTEFDYVVVGGGTAGLAVAARLSEDASVSVGVIEAGLWRPECPKINYPAFIGQTPMNPDYDWCYETEPQQHSNGRKYPWPRGKVLGGSSALNFLVWQRGYKGEYDDIGKLGNSGWSWDDFANFARKSATLEKPSKGLQDAHLATYDEEVHGSDGPVQTSYSKWYTEAQRPWFEALKSLGLANVRDGLAGSNAGFWVSPGTLCPKNGVRSYSASAYYAPNAKRSNLKVITGALASKILFADAKNAAGELVASGVEYSVGGATYTVKARKEVVVSGGTINSPHLLELSGIGKADVLKAAGIEQRIELDVGENVQDHLYTTTTFKLKPGHTTWDKMRQDDFAKAAMEQYAAGGDDRGIVASIISGFAYVPLKQYLSADEIAKIKDEVNKIDWSQYSNGVRETVQLQLARLDDDKCPFTEFIFTPGYFATFSAPEEGQEYYSILACLQQPFSRGTIHAASSDPAQPPKINANYFSVDADLEILSKAVKYCDTITATSPLKDITVARQDPDPEKCTSDDDFREFTKDVTSTEYHPIGSCSMMPREKGGVVDARLKVYGTANVRVADASIIPIHVSSHIQSAVYAVGEKAAHMIREDAKKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN26</accession>
    <name>W3VN26_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN26"/>
    <dbReference type="HOGENOM" id="CLU_009632_0_0_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF89">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="895"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="898"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="910"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="921" mass="102583" checksum="BE9D6E4FC1B702D9" modified="2014-03-19" version="1">MPVQGDPYGHPRPPPAYDVAVRPASPRHQQLYHGRHHSRHHQQHQNHAYPAHDALHTRHAHHAPLKSEYPDQEHAPMMPSHSTSHVTSTPYSAQQSSSSLPATVQRPAHQLVPEQQHQLANIHRFTPSCSRCRQKKLKCDTDLPCNQCIAKGVHDDCRKDARIPRGRKRPKISATSSSGPDEEIAALRRRVKELEDMMARQNRRSSSPRPASSSSSQRLSDKRSIPSHMLGTSSRGSQTSAPSDLDYSHSRNNASPTAASFDSDDDQLPGETETSLTTLEKLAASDPRVTEPGHGKAMAKQINNVSNSQIPPDAPNAYFAPPTALNERIEILTLAKRIIPSKFIADTLIHTFNVRCHSWVGRIVHMPSFQRDIDFFTHASVEECLLSPKGMYDLARYLMVLRLGLRFYPWKASPFTSDSSPEFIAINALKNRGDNVSGQWLTLAKRALAADRTFSLGSLTAIQTALLMILDGRDSPSYLRMLLRIAIQTALDMGLHRLGRAMPSPANPDEDIVRLETGVRIWWYLVVKDWCSAQREGAYTIHPTQMTTRKPLHTTDAMLAAGRTDEISLGEHCEMSYTLCQIGLANIIRESIDLRNEQSMLGGTYDSISPTNRKLLQVKLETFLADLPPFYELESNAMHPPIVAVQRSLLHQQAFNVLLKLNRKSLASYSERATCTLLAEQIVSTQTLLRSVCPVIDGFWVNFLHLFGATLTLIISLLLDSEMDAEARERRRRKVHTALTTMRETPGSDRGSRIIETLLAEEQRLWQSHHGLPLDLASLTRRIVEQTLDSATSAAERGGGAISVPIEAHCGTSVWDVTPDESLIPAFASGWGSAPLDVLDPTQLMPWQPADELYSRPSRPYIDSLRPWQEPSSPRTESGGHNPLWDWLFSHAALLHGPDPPVEGNPNPPQSQAQLPPQSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN73</accession>
    <name>W3VN73_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN73"/>
    <dbReference type="HOGENOM" id="CLU_030437_1_0_1"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF147">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE OF THE SEVEN BETA-STRAND FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="500" mass="54096" checksum="AA75451C3201C780" modified="2014-03-19" version="1">MALSYLEVTALEDMMKQVNPTSCLPRIKEEPSADDLMRALAHLADLYSPRSLTTREKTWITFPEGRCSNVADAAQYADALDSVRVDENEKRYAMSWLTRLIGSGLYWLDSEAGKVTSDELVDLAGRILGGHASIEEAGAITREFVFPLAVPVRVPDIDASAHQDASASDTITITLRDDPLPPSDKHSEASTLSGAGASQDAAAAVGVQTWGAAIVVSDVLVRYPSLFHPTLGLRTGTPLRIAELGAGTGLLGMVAARLLQQRGTPADVVLTDYHLQVLRNLEHNVQENFGLSSDSSGSVSVGVEHVDWLEVHRSMQQGHAQADDADTDKYDLLLLADVIYAPEHALWIRSTIEKLLRKPSPERPDEASARAHIIMAVRGSGKFEGLFKTVDEAFQPRCSFGGVPSLSGSSSATPLDTLPGTPALVSETSAVDVHKTNSKHGDLLRSRMGALSHQAGFSQGSPELAIVTRRRLDKRANVGRNDEQEYLWFEIGWTFPTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN79</accession>
    <name>W3VN79_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PaG_02734</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN79"/>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000058">
        <property type="entry name" value="Probable ENA2-Plasma membrane P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="943"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="993"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1068"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1068"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1097"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ETS62965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122136" checksum="3DC7C9FC8FC3E97D" modified="2014-03-19" version="1">MVKREEEKFPRSDTVQGPDISIDDALESAWQFHYTSVLRALGVEDAEHGLNKRDIEARRQQYGSNQLEGGDEISIWKIALHQIANAMTLVLILAMGVSLGIGSWIEGGVLAGVVAINIIVGFFQELSAEKTMNALRNLASPTARVIRNGDGETISANEVVPGDIIELTTGDTVPADCRLIDSMNFETDEALLTGESLPVAKDHTQIYSAAEEVGVGDRLNMAFTSSTVSKGRATGVVVGTGMNTEIGKIADALRGAAKAQKIRDVKRNAYGKAGPHRYVQAGALTVWDKVNNFLGTNKGTPLQRRLSQLAVGLFFVAVLFAIIVFLSNNWTDNEVIIYAVATGVSMIPASLTAVLTITMAMGSKAMVKKNVIVRKLESLEALGSINDICSDKTGTLTQGKMVVRKAWVPASGTYSVSETNEPFNPTLGEVSVNNVEPRNVKTARDSIEDSGEVVARNGQSDKVEGNDRFEDFMNVASLCNLATVFKDKETHAWTAHGDPTECAIQTFVTRFAWGRLRLTKGKNPDKEVTEKDRDAAKWTQIAEYPFDSSVKRMAVTYVNNKTHQGYAMMKGAVERVLESCVKAQTDDGLVDFNEDFEARVLENMEALAIQGLRVLALAHREISDKEKEQGEELERADVESNMIFLGLVGLYDPPRPETAGAVRKCKEAGITVRMLTGDHPGTAKAIALDVGIVPRNTTKFSKAELDTMVMTAAQFDKLSDAEIDAMPQLPLVIARCAPQTKVRMIEALHRRGKFCAMTGDGVNDSPSLKMSDVGIAMGMNGSDVAKDASDIVLTDDNFASIGNAIEEGRRMADNITKFVCHLLAQNVAQASVLLIGLAFKDDTGLSVFPLSPVEILYVIMVTSGFPAMGLGMEKASSDIMKRKPRSNKWGIFTPEMLIDLTVYGFWMSALCLATFTLITFNWGDGNLGNNCNSDYNDSCELVFRARAATFAVITWFSLILAWEMVDMRRSFFNMRDDGRWYNQWFRDTWRNKFLFICIVGGFFSVFPILYIPGLNRVVFLHEGISWEWGVIIVCTVLFVGGIEAWKWGKRVYYRRTEVDTAKLVDEEAGVAEEHDRTPVDGEKKQHSNEHSRKMVSAPTTSSETTAVHQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN87</accession>
    <name>W3VN87_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_5_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002979">
        <property type="entry name" value="Chromosome 16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1047"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1126"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1240"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1265"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="402"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="738"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1017"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1333"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1571" mass="170741" checksum="5900905D7C7CC3EB" modified="2014-03-19" version="1">MSLSAGPQSLGMLARSVGVKLPFYFTAGARDSALHHIGAGPTWLSLPPDPDSLKSRPSQRGRVAIVRSYPSSSTSSNFEDRTPPRMVRLRRKPDIPTASAQTHLSLLRSCTPHSDPISLFGAFIYIVHAILSLVLVAVLAAPSSRALRHALDAGTGMASVVLAFLTALLAVPLSVAERRKTRGGYMLLPLWLLASLFFTACRIRTFNAIPAIRYSSFFYVYILTFACQAFMLSVENANGVRSTQLQSSHESRASFFSRLLFIWVIPLLWTGLRKPLEMHDLDQLKPEYHGRSLARNFIASWTGAPIEPESGADASEHAHLADTHHHADLKQSPSRTSSEAYPLEKLGTSASESESGAHGSVPKATPSYTRASFPKRRVSRSLLHATLHAFPLAALAPVPWKLLLTATELAQPLLVSTTLAFVQSYSDVSEGGQASAAQPAVYGWGLVGAYAFVYLGQALATGQYWYASSQLMTRLRGAYIEAIYRKGLNLHLRTARTSGGGKAANLMSVDSERVVKAVDVIHSLWSGVITIAVGVYLLYNQLGLVFFASMASVFACFLLTPLASRGIGAKQAAWSSQTDKRVNLTSSVTSDIKGVKFSAYEDVLHFKICKARADELSVRSNMMKQVTGVVVFTNCTSEMLGLSTFITLIIVDKLSGSSRFDLNTIITTLTIFTVLQDPLLKIGQEYSYLLQAYASMRRIEEFLNSEDKPDVQGAVDDGLAARAAAASNADREPAGFAARFQNAELGWQDQPVLSQVDLEVPRGSLTMICGRLGQGKSTLLQAMLGESDLLSGSQQLPLLADRIAYVSQDVWLQEKRSIRENIIFATGEYEEERYMTALRACALLEDIDNLQEGDATSASSLSGGQRQRVAVARAIYSDAESYLFDDITSALDAETAAHMWRSLMAPSGLLSGKTVVMATNAVHLLHHAQLIVRIDGGKIAEQGRYEGLSMKGKDAISRASLDSKRVLPAADVANDKPVKSGAAEKQEAVMTGSVGWGVYVNWVRAAGLWNFGVFVGCSVMSTVAQIGTTYFLQAWATSQQRDPFKALGAWIAGFVALIPGNALALGLGFWVISLYCVESAGKKLHAGELRGVLSAPISFFSKWSSGQITNRFSQDLYNLDQTFTQALTNLVFIACGLVGSLVTMIVPAPYLAALAVGLIGFSWALQRLYIPSSRQLRRLEMAAKSPLYSLFSETSSPSGLATVRGLKREASLVELNTQSLDVSQAPYYHLFAVRRWLQTWLLLLTTVVNVMLVLLVVVLRHSSKAGLFGVALVQATSLGIMLNHTVISITEVEIAGVALERVREFTDLQPEEGATPERKHTYDNAREAIRGDIEFDGVTVSYSADLEPAVKELSFTLQAGQRLGLVGRSGSGKSTTLLALFRMIEMRSGSIRIDGRDISEMGARELRSQMTIVAQNPLVLAASIRENLDPEGVCSDEEMWDALHKCHLAEFVKKQENGLEEVLLTGKSFISSGQKQLLSLARALLRKRKILVLDEATSAMDVETDAAVQNVLETQFADCTVIAVAHRIATIIGFDQIICMSAGRAIESGPPQVLLKARGEFWALAAEQKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNC3</accession>
    <name>W3VNC3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNC3"/>
    <dbReference type="HOGENOM" id="CLU_048756_0_0_1"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="312" mass="33992" checksum="C6E96E65C1F04E54" modified="2014-03-19" version="1">MSSKPTAYPFHQVDVFTDKAYFGNPVAVVNCLDTSLPLPSQEQMQRFARWTNLSETTFLLPPSQSAEANYRLKIFTPVEELPFAGHPTLGSCYSFLRHLGDERCSSLLESRGGKLVQECAIGLVPLQVSPDASEVRFLAPEFVRYEPVDAATVERITRALCLDPADVLEAHHIDNGPHWIGIKLPSAQHVLDINPTNPGCDVASVRDLFFGFIGPYPDGVNADGERLANEVRAFVFADIGEDPVTGSLNAGFAKWLEATGNSPATEYVNSQGTAIGRKGRISVKINRTTSSEKSEIWIGGSCTVCIDGQVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNE1</accession>
    <name>W3VNE1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNE1"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="537" mass="57666" checksum="59E8C657E26201F0" modified="2014-03-19" version="1">MTDIQPTPHRDDISPAGEKIANPAPVDSPPAQPVAKKSRLGAVGLIFACGAALFSDGYVNAASGPTVTILSYAYPDYPGFATFESRFSSLVFAGTVFGMLLFGFLVDRIGRRHGMWFASIWLCLWSVLIAGAWGAGGSIGGLFAALAAYRFIIGIAIGAEYPSGSVAASENTEGEGVAKSRQQMYFIIATNTMIDLGFVVAVLVAYILLLIFGINHLAWVWRLTLGLGAIPPLLVFFFRMGMQEPEHYRKGAIKKNIPYLLIFKRYWVRLVAVCLAWFAYDYVSYPSGIYSSIIIKQLNPGNGSDYDTLKKSLAYSTALNCFYLPGTIIGAFISDRLGPKHTMILGLLIQAVLAFVMGGAFGKIRESLGGFIVVYGLFLAAGELGPGNNLGLLASKACGPAAVRGTFYGIAAAIGKVGAFSGSYAYPQIQADLGTPDDNIYYAGPFYIAGGLAVFSAIITFFFIPTIGQDSMKHEDEAFRQYLADNGYDISQMGLVDKDHPATFEEGSRTRSTDEASVENKEKSQGHEATVTSTAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNK1</accession>
    <name>W3VNK1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNK1"/>
    <dbReference type="HOGENOM" id="CLU_1078187_0_0_1"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="80"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="258" mass="28619" checksum="D9D3A868178D01DC" modified="2014-03-19" version="1">MADSTDATAAGSPTASPSISAPTAGPSTSPRSKRAVSPVAEEAHASSSDARPRRSRSPERAPSREPDAPAAKRARSSDGEDRKRDRRMFGLLTSTLTQFKRESQSTRAATLASNRASIEARLATKLRHTSAVAQGLERKKTLLWQARELAERMAEQDAQRATLRKMKRRQASFLFTHNRTRSDPTRLAAHIPTSQPPRETDWPVYFLPGKTLPDQEDALNAQEDGVDDQIEEHDDAWTVKRNTLLARLNDLKSQLRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNX9</accession>
    <name>W3VNX9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_01649</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNX9"/>
    <dbReference type="HOGENOM" id="CLU_023894_0_1_1"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="17">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS63368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="535" mass="56276" checksum="0C1D12F0C3276A6B" modified="2014-03-19" version="1">MFCAISGEPPKVPVVSRKSGLIYEQRLINKYINDNGKDPVTGDALELDDLIEIKSNPKTAVPRPPQHSSIPSLLTSLQNEYDAIILETFTLKKHYDNLRQELAHALYANDASARVIARLLNERDQAREALASIQGTIGAGPSSSKAAHDVEMTDSAPAGNGASNAAAGNGLSTEVVEIIDATAQRLSSQRKAKSKRKAPEGYATQSSVASFAETQKLPSMHHAKPAGVSCLALSADGNVLVTGGNDKNVQVYDRKEDKVLATLKGHTKRITRVAVSGASDAPIGSEAASDEAALPSYVVSASEDGKVKVWTPTGATGAKAQAYAVAHTGSPHQGEVTGLDVHPSGALFGSAGRDGTLSLRSLDDGSELLRVDAGLGDAYESFAFHPDGQLAATGTAQGAIRIWDIKTGQNVSTLQTELSGPVTALHFSENGYYLAAASDQAKAVEVWDLRKLTAAGKMTVEEEGKGGVSAVRFDPSLQFLAVATDSVTVYANKSWAQLARMEGTANLTGLDWDHRDGSIVVSSLDRTVRTFGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNY0</accession>
    <name>W3VNY0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNY0"/>
    <dbReference type="HOGENOM" id="CLU_127249_0_0_1"/>
    <dbReference type="OrthoDB" id="2556238at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="160" mass="17390" checksum="3D8CA8ED7EBFEE78" modified="2014-03-19" version="1">MHTLLSSSSTPKTTMFKLFRKTKATTGASIMEHANGSETTLVSTAAPKRKTRREYQPYQAEFSGLSSLGGMPSLGGHMFMEPPSPTKSSPKAKLNMVPAQPFERSPRASVVQARLETVQGRGSMETLTPTASTSSTSSESTQRKLKKQHKTFFNNAFGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP13</accession>
    <name>W3VP13_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol oxygenase</fullName>
            <ecNumber evidence="4">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_01555</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP13"/>
    <dbReference type="HOGENOM" id="CLU_050259_0_1_1"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="243"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="299"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="375"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="443" mass="49848" checksum="8F0FEAF0A64D1418" modified="2014-03-19" version="1">MLLTGAAGRPTALPTRHAQPKLTGQPPYPWAYSAKLCWSPSKHRTGADTCHVVTVPSIPLRTAAQARAPPGAKACGVQTYMTARHARSIPHIPSPLAFDVAYIHYQQSHLIIMAPIAVEPVLPVVAPVKTASTIVAKGTAMDAISDMVDEVNVYRGQHPEAPQPQSSEDEAWRTEGSQFDSEKDKADFRRYEDALDHVKAFYKTQHEKQTVAFNIAARERFLKNHHASMTVWEAIEKLDTLVDESDPDTSLSQIQHLLQTAEAMRRDGKPDWMQLTGLIHDLGKLLCFFGADGQWDVVGDTFVVGCAPEGTVYPHTFENNPDFHDERYNTKYGMYEPNCGLQNVMLSFGHDEYLYEIAKRESTLPQAALDMIRYHSFYPWHREGAYRHLCAPEDEDALANVLAFNPYDLYSKSDSPPDPVALRPYYESLVEKYFGGKDRKIQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPP1</accession>
    <name>W3VPP1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02469</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPP1"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="100"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="590" mass="64753" checksum="8AC6CF958638FBD8" modified="2014-03-19" version="1">MGDYIAKSKAHRAKRDASIPASYLADLSAAGVAPLPDEKLPLPFSKSKPHMPEPTTIYPTDNVMGVPGKVLSLEDVAITETPIDKLLDLLRTGKLSSVRTTEAFLRRAVLAHQLTNCCTDIFVDRALARAKECDDTLASTGKPIGLLHGLPVSLKDQFDIKDTEMTMGYVGWIGRVAKSNSVITDVILRAGGVPYVRTSIPQSLMRCETHNHIYGRTVSPFNRSFTPGGSSGGEGALVGMHGSPLGLGTDIGGSVRVPSAFNGLWGMRPSMHRTPYQGAANSFLGQESVSSVIGPLTHSLEGVVTFMRAVLGERPWELDPILVSMPFNEDAYALKDLQLKKGSSEPTESYAAGKTQLCFAIEWDDGIVHPHPPITRALRETKAKLEAAGHKVIDWVPYDHLRAYDIIGRIYSADGGEDIRRSCEQGGEPVMYNLMADGKEAKHLSTYESWQVNREKSAYRKEYLDYWQATKDKTGTGRPVDAIIAPVSNWASCPHDTNDHVSYTTQWNLLDRPCVVFPVGFVDPAKDPKTALDKPYTGLPDNADQEYWDRYDPERWAGMPINLQVVGKRLQDEELLGLAKVIRDAGATLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPY5</accession>
    <name>W3VPY5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPY5"/>
    <dbReference type="HOGENOM" id="CLU_079179_0_0_1"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28336" checksum="2DA43C14C9F5A236" modified="2014-03-19" version="1">MADAADTSRTSVAAQFEPLFAELEAERSRSDAIREQAKELDRCHRSLALLLNSVHSTKDAEKQIVSESQPIVVKIRQRVGELAELVPQGQFYRWCDDFSGAVRNVTSSIALLVLLSTGSLVTKTQVEQVMGVDEGKASVHVATEDYLHGIINMLNELPRLAVNRVTMGDFRTPVRLASFVKQVHAGFQLLNLKNDSLRKRFDGIKYDVKKIEEVVYDISLRGLVKHQDSSEEGLAFPLPPSEAQTLVDQYQRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ06</accession>
    <name>W3VQ06_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ06"/>
    <dbReference type="HOGENOM" id="CLU_1971466_0_0_1"/>
    <dbReference type="OrthoDB" id="10427667at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="127" mass="13883" checksum="51854EB9241604D9" modified="2014-03-19" version="1">MLLKAATPFDDHLLEVWLVSDAMQGRVRIVEYSQSGIGEEAAVGGGWEQRIMSSDPASTDVHGAMLGHVLRCVPFWMISTVLREGDDGPAPGYRSNGSGFRLVPQRSRRRADAFKRTISAGRIKDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ14</accession>
    <name>W3VQ14_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ14"/>
    <dbReference type="HOGENOM" id="CLU_586852_0_0_1"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="488" mass="52610" checksum="03A13DA55F343ACE" modified="2014-03-19" version="1">MLLSPPSNPHLLTTPASPLTIPLDAAPSPASDASMTAFTFPSPAVNSYGSSPSAGLDLYTKSIDPTSDRIGELQKFLLGSDWSSLSSLSPPSASARAVVEDTLSWPSTEMTDAPLFPSSADTLRPAAEPTAAVQPVDNVSETGAVTQSPPATISTVAAPAAYDSSVTPLHRQSFEACYSDSVGSPDSERDFLTSPSMFDDADFEFDADSLANNFPLFGANTFEDVSDSHAEDPMTTFASNLENVKLESEDHDSQSSDVDLAASQSTVMPSYSQVKSEHDSHDTMSTLEAAFKVESDADGSAAKREQPYDMWSADELKPYFSDEDIKAAELSTLANAFGAEPLKLPLALEFDLDAAKDDEKHDSHAGPIRSSRGSRDQRRASPVKALGGASASTSASPAPIIDPVTKAKRWQCHECGKWFDRAYNLKTHRYTHEDPETRARPFVCPDAECHKHFARKHDMQRHFENVHRGESRRSKGASTKRSRAGDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ95</accession>
    <name>W3VQ95_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ95"/>
    <dbReference type="HOGENOM" id="CLU_055193_0_1_1"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="174"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="316" mass="34583" checksum="7A7012964BAEC31F" modified="2014-03-19" version="1">MAQDADLVSMTPLLFSRSSYPSPVSRCVFAFDFSSLQPKAKTGSAKKPAAAPYSKGKATKAPKNPLFEKRPRNFGIGQDIQPPRDLSRFVKWPEYVRLQRQKVILNQRLKVPPAIAQFANTLDKNTATNLFKLLNKYRPESKQEKKARLDAAAKDIADGKKADAKADGKKPLFVKYGLNHCVALIEAKKAGLVVIAADVDPIELVVFLPALCRKMGVPYVIVKSKASIGALVHKKTAAVALIQEVRSEDERELANLVSAAKANYLDKAEEIRRHWGGGDLSQRSNHKLAKRAKIAALQPKPVAVAAPVAAAEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQD0</accession>
    <name>W3VQD0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-1,2-mannosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQD0"/>
    <dbReference type="HOGENOM" id="CLU_003690_2_1_1"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000001">
        <property type="entry name" value="Putative alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF43">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834793" description="Alpha-1,2-mannosidase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="377"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="99382" checksum="E2F266F83B38D610" modified="2014-03-19" version="1">MRVPTRTKAPALRLLALVAALSATLASVRAHQTPFAADDSSTATTSSAHDFVPPPCYPFCDASEDSVSEVEAARYKHRAGTLQWVDPRIGTNGPDPSEYGGMVPSVALPFAGVRTVPMTRENLVSGCAYHDNDTVNIGFLASRQPAIWMGDYGFATLFAGNGEVRLGKHERGHSYERSQEFVSPFKYAVAMSNSSLAEDGIFAEMAGKSRAAMVQYTYSAALNSSLAASPAATHSEHESMLAQLSANHSEWGPYIGIQASREQWRGAVRIDVHKGEVSGYNTERMDYRLGPHEAPGFRGYFVYRFEYQRGGASSDEWVRGFPADGVGTAHSNATGITLHPGERARWNELGVYAYVRFPTDTTKIRVRVGLSLISEEQARYNLDVEMPDETALEDVVDELIDAWKSKTDRVKVQGGTEEQKRILYTGIFHASQYPAEHAEPVPDTHKPTNRSEAAPLLRFGHEHEHSYHYYSGYTDSVHRVDAGVQRYQSWSIWDIYRAQWNLLILFEPERIVDMVRSLLDIYRQSGFLPMWSTLAETNIMIATHADSLLAEAVVKGVRGFDLDEAWQAVYKDGTVPPEREIELRFEDREEYTPLEVRAGLSFYNHSGYVPLDGWSESTSRTLDYAYDDHAIAVLAEVLDKQSDASFFHNRSRNYRHVFDHDQGLMAARLKNGTFLVQPLPDPRGRQEGFTEGNSFDYSFDVVQDVPGLAELVGGRAKLTALLDRHFSEGHNDQSNEPSHHIPYLYTLLGEAHKTQRLVREISHEAFSDLPDGYAGNEDCGQQSAWYIWSAMGLYPVNPVSGEYVVSSPFFEHMEIDIPPRAPGAAHGTKLRIHAAGSDDDHVYVANLTVNGHAIARPKLKWDDILAGGEWTFGLQSSPQKWGNDPESPPLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQG0</accession>
    <name>W3VQG0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQG0"/>
    <dbReference type="HOGENOM" id="CLU_038617_1_1_1"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834497" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="132"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="394" mass="43890" checksum="9BFEAFD3D194345E" modified="2014-03-19" version="1">MRLLSLTLALLVLVATALAGNVLDLTATKDFNQHIGKSQGVLVKYYAPWCGHCKSLAPIYEKVADAFAHQKETVLIAKVDADKNKELGQKAGIRGFPTLKWYPAGSTEAEEFNSGRDLDSIAKLVTEKSGKKSTVKPPPPPAAEQLTNRNFDKIVMDENKDVLVEFYAPWCGHCKNLNPIYQQVAQDFSGDEDCVVAQMDADEESNKAIAQRYGVSSYPTLMFFPKGDKSNPVPYNGGRGEDDFLKFLNEKCQTWRTKGGLLSELAGRMPTLDGFAARWYTSPADKKSTIYSEFIDYVNTMKASSKVDKKKSEAADYYLRVLDKANQSAGYIEKETKRLSSILKKHAEGTSQLAGRKVDELTKKKNVLLAFVNERIAAQAEKQKKDFEARKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQU9</accession>
    <name>W3VQU9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQU9"/>
    <dbReference type="HOGENOM" id="CLU_624249_0_0_1"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="439" mass="45694" checksum="C9856329E2D22BBA" modified="2014-03-19" version="1">MPGSTPTLQHPGRSAPVRGVASQQAFTSNPLATSANVNTAAVSTLSPHQQHGQQMAGVVATTTHPQGWNRAYSSGMPAPAVAVPIFRPSRAADVGSASIDRRTLADHQLPDSPPDTPPHSPGLRPVQMPSLIESGSFSQLQRAQQQQQAQLQQQHQPRISPSAHSLPTEAARDADAVDPIYTGHTPCDSELESDDGSDVSDDASQATLAQLTLAAQSLLLHSDASHRSKPTHPVAAAHRGTLSVELMPATPEISPDNDVRHHAHKSAHAFLHRIFADVPHNLSVEDAGVELVSPGWSGAVIKSHSAAGPASAHASSSFSSTSSSDSSADAQRTLYVSMPAIVDASVLREQVLAVLDAASEKLGCDSVMICLDRALRDFASVLHGLCYVGGALVAASAQTTSGSDKASDHFSAGPHRLPDTDPVSGLALRSGLVLVAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR48</accession>
    <name>W3VR48_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR48"/>
    <dbReference type="HOGENOM" id="CLU_061244_2_0_1"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833309" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="29956" checksum="B15923194C58B93D" modified="2014-03-19" version="1">MKLFSTLSGLALASVLTSSWTHALPSGLDRRQSETQGYYSPATNGGSMLTGNTASGLGEPLNVIVSGQSDSGVLSQDGFEEFSRALYFSPGSCLNISQGGYQTANLGDGNGAKPQTNIMRYNFKQGDGGTCLESLKGGNHFRYWIQNGTAANSGAIFIAASVELNATLNHAIAPNGYDDGRDQLVGNATAGTLTSPGGFQYTVSRQSSSQLLSGASASQINHDIGIDGVVDVLTVRITKNGSIGTGRSSASSGGSTSTPQQSSAVSILTLDLRTSAVATLLAVSVASGLSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRI7</accession>
    <name>W3VRI7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRI7"/>
    <dbReference type="HOGENOM" id="CLU_1415725_0_0_1"/>
    <dbReference type="OrthoDB" id="10360139at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="192" mass="20146" checksum="00BBBBFB0A8E54AC" modified="2014-03-19" version="1">MRSCRAEAAASSLFAAASASEPVLHTLPPATVPCTQGMAIAPRPSRHFCLRQASLGRRCSAFPASAPGMSLDVRTAGPAQTAVEPSIGACPSPTPVRPAHLKGLPHPAGSTVEAFGQGSRPLDACLLLVASRLPWRLRIAATSTPDAKSASKTLGSEPRPKPPCMRLICHTRMPGSLRQHPRRHTALFLTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRQ6</accession>
    <name>W3VRQ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRQ6"/>
    <dbReference type="HOGENOM" id="CLU_000288_77_4_1"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="404"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="481"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="638" mass="69636" checksum="32B72BCF4024DF32" modified="2014-03-19" version="1">MAPTATEPASPGSPSLKAAKAATPKDDGRSRSGSPSLTPLPVTPPEADERASTSKRTLEEEEDLEASRLFPHHARPPPYKKRVWVPTLHLTQAPQPPQPDPRTVQEMAAQQAATALGYEGRRIKKFMQRRTVDYFGALPRLGLRRAFASTTRVDGLHGLVYPSPHAIPNFLLPAGYDNLATSVPSVMVHTSTNKIRCPVNVVKWMPDGRRLLTGSTSGEFTLWNGLTFNFETIMQAHDSAVRAMAWNKAGTYLISADQNGTVKYFQSNLNNLQAFTAHADSARGLAWSPDDSKFASGGDDSLLKVWDFDSAKQIRELTGHGWDVKCLDWHAYKGMLISGSKDNLVKVWDPRANPTGTCLATFHNHKNTVQACKFSPDGLRFATASRDMTVKLYDLRMMAEQTTLKGHTKEVCSLDFHPTHHDLLVSGGSEGSMLFWDLTAATNEALSESNFVERSMMGGGGEGMDVSEGRRMDEALLWANHTAHESNVWSLEWHPFGHILCSGSNDHMTRFWQRARPSAVTQSHATSTLDVPVSSFVDNPDDSFIPGLAAANRSFIPTNSAPKEDEFAIPGLGLPRAPPSQPQAQQYHAQQPYQPQGFTPGTGANAPLPGTGPQFGWSARGPAPPTQQAPGGTYGAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRY5</accession>
    <name>W3VRY5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01483</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRY5"/>
    <dbReference type="HOGENOM" id="CLU_009032_0_0_1"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="10">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="569"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="710"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="780" mass="82209" checksum="1E3D7E2F4935586C" modified="2014-03-19" version="1">MDPPTNQPAGAASSFKTPQMDQSEWSAATPTTTTTPSRHTFPRRLSLLQNEAASPARSDAPQEGSRRTSFTGPKPLNLVSQPLSSAVPSSASSSAGPDTPRRGKRTSLSYIPSPSTSKIDDGQLSRAQSTSSASGRTRTGSISRATNASRRRPSQASQASAGANSDADDWLMSEEDASFSLPSAARAMAQRDSAKVEAQFQDTGYREGITAGKLSTLQNGFDQGFNEVGAPLGREVGMLRGQLAALLLLTSPSPSADAAAPRKAVGRATARMRPANSAATPWLPLLAHPRLAEAHQEMRALAAELDSVSLGQLAEPDYEALVHDHEHAAEAGDAAAKPTRETQEQRRARTAVLVRLHARLERVRDMLGLQNGALTGQTRDLLRLIAEKERRCFELRDELAAEEVELKQLRAAWQRTATRELAYGTSPTHRRNGSASSSTTRPSLARTDSTDSTAGLPVGVPQAAAEAWNSISAKLPGGLKSQLNSLLESIAMDQPPEVPEKRVDEGGLRPAPLGTLGVLEEEGSDVGSAAVSPRSPRSPAVPVAGGRGAAHAQDDSSVLGFKVDANGIATPSVQLGEQPPPTPPKEGVREGNAWQSRRTSVLGSWSQLQSKLTGEADSGGGGLAGMFSRRLREARDNASDLLREAERKLGNAMTIDDLLGISNDEPASPQPPMARSRSPQIRLEGVATQTSWAEAAVGVRSPNLAPADAVGRTSVSSSRSSLSLQLPVRSASPHSPPIGGAPGAAAFGVLHNGSSSSINRISANSVDGWNWTKHEQEWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRZ9</accession>
    <name>W3VRZ9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRZ9"/>
    <dbReference type="HOGENOM" id="CLU_024076_0_0_1"/>
    <dbReference type="OrthoDB" id="2556600at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="523" mass="57178" checksum="1E6DFBCA8FD7E645" modified="2014-03-19" version="1">MAAPWTWRLDPSSGSASVLGPSPSTIAVSADPLSALAQSTETASADDIVWHDFGPPPRPTSARQARKRARLNRFDSDDDENFDQTLRTEPSSHDHADAVPGPVAELDAQEAREDDENAGLASTCSSDSESNDEDPPLREPQASQSCSLQLETRKHPEISLQKARKSTRTNSEDAFAESTRLMAHTIYTYSLADEAKRPENTDPPSPLTYKETVRLVRLIAMIFRFPKPTRRVSRRHTDSADIASPPSSSQSTPTPAVKDESDDEKFKIELKPKYLSSASDGGSRRPRMLARVHPEDTRVDSAAVLKMLALVPSVLPARVGDAAWIVNLAVRARRDEYGNILLPDSVYASAQPADTHTGSTTCKGENEGPQKITRSLVHKLGREAPAIPLPQFWRRRSPSASATHESDCKEHNAQERPLPNAQANVETLTTSAAETQQDAAAAEESGERAVNLSRLLADRMREKRQAKTLLLRTHPTLRKRRPAQTSSQAVQHDAENEADALTAANTAANALSHSQLPLPDHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS04</accession>
    <name>W3VS04_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS04"/>
    <dbReference type="HOGENOM" id="CLU_181700_0_0_1"/>
    <dbReference type="OrthoDB" id="3355804at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="99" mass="10382" checksum="F2ECAF49C336AF0B" modified="2014-03-19" version="1">MSNLNMSSGPQQEVADTLPNNYSLGGGNMKADPKVPINTIPNPEAGRDDVNTGGRGGDVLRQPVHAHDIDIPANKPHLHAGANETHKQIHSSHSGPGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS08</accession>
    <name>W3VS08_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Low-affinity zinc ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS08"/>
    <dbReference type="HOGENOM" id="CLU_027089_1_2_1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="467" mass="50602" checksum="AC93980C95A03D6A" modified="2014-03-19" version="1">MPVDADPLNTPAQVRRHRSFAHSRPRTTGGLDRSATTTMLLVLVAASLAPTVLAINGRPDDSALPEECRRRGAGNESYTLSLHIAAIFVVFVSSSIGIVLPFVPLWLKSRPIPAANDDDDQHTHAHGHASGLPRTWWDELFFIGKCFGAGVILATAFVHLTYEAFIQLSSPCLNLVYSPMAPAISMASLFAIFLVDMLLMRHIHRSRKAMDELKARRAKDKAHLESLTLLSIRPIDSPAPVDVDMAMLHNASSLPTWQAVVPGKTPDGSSRADGAKPLDADMLNERLRRNEMIEQEEKLADAKLRQRAKELDVMIIEGGIVFHSVMVGLGLGTASDAGFVPYFIAIVFHQMFDGFAIGTRMAALDFVGRRRKQAAMFLAYAFVTPVGIALGTGVRTVFEPNNPSTIIAIGVLDSISAGVLLYGALVDLLAKEFLFGPMLDASDRRLAVALASLLFGAGVMSLLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS88</accession>
    <name>W3VS88_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type II protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS88"/>
    <dbReference type="HOGENOM" id="CLU_028484_1_0_1"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="644" mass="72483" checksum="B5006720512AD048" modified="2014-03-19" version="1">MVVATGGASKRLVRCAGAALHTAALPTTQRLLASGSQRLPVVSATASRTRTVLGSGGVRHASSSGNKPTEDEAERHRTQYNYDPFTLHPDAKHYSYPLVTADDLAARSEAHSSDRREGGEEKVMGPGGRPREVRMLARDFIHDSLYNPRYGYFSKQAVLLPDADPASSKGEEQYEMVGGETYEHEMGVLRPSSGFEFNAIKNESEFMRMVEERYESFETQIAVLVQERQNALDAQTKQDEFAQSVQRERRERVAKRQEGAATRVAEYSAAGLEAAQRKGRAMAREGVQEADVQSMAAKQVWHTPTQIFQPYYAHAIARYLVAEYKLHNYPYDDLVIFELGAGSGALARGILDYLASSEPEIYTRTRYRIVEISERLAQEQRRKLARHAAAGRVEVVHRDVLAWSDEVVEPCFVIALEVLDNLAHDVVRFALEDLTPYQGVVSIDETGDMHELYEPLSDPLIQRYLQIIGRDLSPLQSSYLRLLPDRLRSVLAKHAPFFPNLSDAVFVPTNALRLFDTLNRFFPHHRLVMSDFNALPDSIGGVNAPVVQTRINAQMVPVTTYLVLQGYFDIFFPTNFAHLAKMYHAVNGAFFSPHFSPHQRKSRAPHVLGHAAFLERYAEREKLVLRDGSNPLLAWYQNASWFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSK5</accession>
    <name>W3VSK5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01088</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSK5"/>
    <dbReference type="HOGENOM" id="CLU_008539_6_0_1"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834837" description="Alkaline phosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="556"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="587" mass="64393" checksum="004FFD07ADDEF27E" modified="2014-03-19" version="1">MQLQGLFVQLGAVVLLAITASAAPNNGKWNAKKAPNVIQLISDGFGPASETFARAYMQSAQHKAWNVTLPLDKLLVGEVRTRSTDSLVTDSAASATAYSCGLKSVNAYIGVDSDKKPCGTVLEGAKAKGYNTALVTTSRITHATPASYSAHIDDRDAEDEIASQQIGDYMLGRQADILWGGGLRHFLPNTTKPGIRTDGRNLVEEAKKNGFNVVNNRSEFDALQGGQALKLPSMALFTSSHMAYEIDRNATAEPSLKEMALTALNGLRNAGEPYFIMIEGARIDHAAHNNDPIGHIHDILAYNEMVEAVVQWVDANAADNPHEPETVVFSVADHECGGLTLGLQRSEDEESFYGWYPDVLFNATHSTEFLAAQTAKWLATNKTDAELRTYIKDEVVSKGLGIMDVQDGEVDRAVELAKLKNQIPYTVWLSSIVNWRAHLGWSTTGHSGVSVGLYYHEAKPQQGGEKLKRYQARRASVVGSHENTWIGEWIASFLQLDLATITHKLNNGSDYSWYNNWGDKLNTFTDALEHYHGGLARVIPPRAAADKRALHVESHAENEPILRSIHGPRGGKTLEERSHSQARREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSQ9</accession>
    <name>W3VSQ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSQ9"/>
    <dbReference type="HOGENOM" id="CLU_013649_2_0_1"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="491"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="701"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="799" mass="88449" checksum="481BA18DDB100B40" modified="2014-03-19" version="1">MVKKPSKAQKAKLRKGGDADVDSANGRGGRGGRGGHGRGRGRGRGGGAAAGGGRLGRSSLLPPEQQAAFESRKRTVQLEESAFSKLSPPVLERLNILASYAHLYRPVPANLVHFDYSRFGRARAENHQRILDQKQSEQHVRQSHPLAGWLDTPSKQADSEELSDHEDAAPDEDNVDGIEETGELRLPKRPKWRADMDTKTVLSQEAEVFRQWLHKTDAVVERAFFTSSPLFAGLESHTRSQDKAAFTTAPSMGGSRMVASIASADTITKLLDHRPAPGTSVIGSLYERNIEVYRQLWRVCERSDLVCVLADARCPLLHLPPSLVGFLERYMRLKVVIVLTKADIVPKRIVDAWQTYLKQRFPRWQVVATESYAKLERMEGQGARTRFAPYLSPGSRKALFGALRTAHAELVTPPKAVLEDEAKQRQWVPPCATDTDWEGVERRVQLHTEGFGPDDHVDDSQSTEQVEAPPTRDQDAKSKDKTGRQPLPYLTIGLIGQPNVGKSSLLNALFGAKVVRASKTPGKTKHFQTHFLVPLTITPSTTPRGLGEESHRGQIRLCDSPGLVFPSLIGMEMQVFGAVLAISQVQAISSCIRFVAEHIPLERVLQLDYPYDEDTPEAEEQQQWTGVKVLEAVARRYGYKTAKANRWDVNRAGNLVMRAVAEGRIKWAFRPPLSEGEQEEGAEDGIWIQDAEKQVERGEDLLTAPNPDDEEDEPKDDEQDEGGSSDGVDMARKVRFDFGAPDTNDSDEDDQEEEEEQAGLGGSTASLFSALAVEDAAEEDEDDDDEDDDDDDDEDDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT38</accession>
    <name>W3VT38_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT38"/>
    <dbReference type="HOGENOM" id="CLU_012743_1_0_1"/>
    <dbReference type="OrthoDB" id="5541877at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039966">
        <property type="entry name" value="C553.12c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="758" mass="85624" checksum="800113ADB12B4AAB" modified="2014-03-19" version="1">MFAPMSKGGSDDAWQAQDEAGSLKPGRFRAYLADQLLAPGTTNPTPASRSIPFPRDSGTSRRNAKPAADKGKARELDRGFMAGFLDNQPAAPSTSLGKRLANGFGFRQNPTHPDRPAGLRSGPAPTKTRNLDPPDAYYPKSMRDPAAPSSGAKSPLSSSGELGPSPFHSPPPRRRRVTSIRDRNWERERERERQRPNRSWLNNLIRPPREIVEAWLDSWWKRWFALAGLPSLVVWIWCAVPFPKTDPYDPNLPWCNPGEDGSWNDPSNPPWCYPPNATASSSEITSKMAVPTLPTLTGLAWSITNLIASSFSKRAGTPSDPHPPIGGGDHLTVDANFWFFLVFYYGIYVGVALVYITQLFGLYRLNWWPAALGAKTSYTFFWIGSLVAGWILHQLDPLGTESRHRSAFSKGRPHDEPGSAVQQCSAGGKPTIDDADIQWQRKTLWVGLAFATMAMPALVCFVGLRRSGRQTYRHSLTDHQKTFLERQLNRRIPSSYIRFLWFMSTIGLSLFALIAGQGYASVYLSTLPHTGLDGVAYVSFWTLTVNGLALVSHWILESKVRSRALVFAFKYYYFLVYFIFYRNLFARLRSFDQFALVQLLSSFWVCIWYPLSMSSLCHRVVQYFNPSPRSWEEYVESVGLAFYLRNLAQNTTMLAFLGWVSILHFGSNQPLYPFFAYDNKHDPYNYQLTMLGSLAIWASELVSSFVARQICYLAFRVDVTNLGLDEMREFPELLPTIGWGAVHTLMDMLLFLIKLNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTE1</accession>
    <name>W3VTE1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Thiamine phosphate synthase/TenI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_00785</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTE1"/>
    <dbReference type="HOGENOM" id="CLU_019943_1_1_1"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="15">
        <location>
            <begin position="13"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS64819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="562" mass="58767" checksum="8651138B0C8D642F" modified="2014-03-19" version="1">MSTLDKSKVDYSVYLVTGRELLPPGVDYYESLERCLAHGHVTVVQIREKDAETNEFLEIAKKSLAICDKYSVPMLINDNLSVCLSLPERVGLHIGQEDIPVSEARRILGDKRLLGISVKTIEQAAKARQEGFADYAGVGPCYGTQSKAGITEDKVIGISGAQKIVAELARGTRRMPCVLIGGLNQKTAARTLFGATSSDNAPDGIAVISAIVARADSDKAAEELAHIVRAYKVGLDASASIYDTWGLSSAFALPPELNANAHDAEWYKNAAADLLGLHRQGVHGPPLIQTITSHVSSTMSANLALAFSASPIMSHEAAEAADLSRAVGALVLNIGTISPASREGMYVAGTSANRNLKPVVLDPVGGGATQFRKDVVRGILNHTQVTLLKGNAAELASIAGKSDEVQSRGVDSGAGQLKDPVGLVRHLARTERCLVLLSGKTDYLTDGETVIASTNGHPLLGAITGSGCALGVTVATGLAAACNKAKDEEPAISLGNTMVAHGKVDLLVGALMGLLGMTIASEKAARRDDVKGPGTFIAALQDELAAVSPEDIRAHAQLEVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTI3</accession>
    <name>W3VTI3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_01352</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTI3"/>
    <dbReference type="HOGENOM" id="CLU_008554_2_1_1"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="79"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="521" mass="58188" checksum="90727C639C2F6B40" modified="2014-03-19" version="1">MQVLVRRALRSASSSRSATVTGSLLKHFLQARHSSSKPAAQGASQDASGSSTTDHRAIGKAQSLFLTHDSSPGTPFILPHGMRLARKVERVVRDLYDVYGYDEVQSPQLYKTSLWKRSGHWDNYRDDMFAAEGYKERLARTSASTSVDDRTACCSIHAEEREVEDETFGLKPMNCPGHCVIFASQERSYRDLPIRYAEFSPLHRNEASGALTGLTRVRRFHQDDAHVFCTPDQVEAEIDAMLQMLTSAYDTFGFAAFELVLSTRPDDAFIGSVQEWDRAEAGLREALDKSGRKWELNEGDGAFYGPKIDIRLVDGQGRRHQTATIQLDFQLPRRFELSYADPSATQTGERSTPVMIHRAILGSVERFMAILIEQTAGWWPFWLSPRQAIVLPAKTGSAELDAYAARIAKYLSLGIHPDAEASQSSERHLQRFYVDVEANPQGEKLAKLVRKAQLARYNYILVVGEREMQTQSVTVRKRDDSNAPKNLTASTTAAAGAIANNAQIPITELRRIFCQLDSSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTU5</accession>
    <name>W3VTU5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTU5"/>
    <dbReference type="HOGENOM" id="CLU_091402_1_0_1"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="256" mass="26806" checksum="DBB51992B1E2AF61" modified="2014-03-19" version="1">MGLLDKLASKVGGNSGRPPSQQYGGAGGYGQQPPYQHQQHQQQQQHYGGGYNQAPPQQSSGYPAASPQPQGEEKPKDDDRPLPEGWVKQWDSNYSRYFYVDTRATPPRSIWVHPSDENKSSTPAAGGYAPPPGGPPDNRGYGQQPYPQQQYGQPQYGQQPYGGYQQQPMYQQQPMMAGGPMGGMGGMGGMGGRRFGGGGGGGGMGMAGGAALGLGAGMLGGALISHEMNDAYQDGYQDGAQDDYGGGGDDFGGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTU9</accession>
    <name>W3VTU9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTU9"/>
    <dbReference type="HOGENOM" id="CLU_2387096_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="94" mass="9616" checksum="6768696B1EC8BE63" modified="2014-03-19" version="1">MLTAVDAPVSRIELAFGGSRKLFSTSSGDPVERAVSILHEHLEPAKPCDVTCGGPSGAYIGKPKHASGRKSSETFSAPVARLGTSASAPVPLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU79</accession>
    <name>W3VU79_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU79"/>
    <dbReference type="HOGENOM" id="CLU_1603454_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="166" mass="17809" checksum="17432B89208A7663" modified="2014-03-19" version="1">MGTAKQRTPCGGKLSGADQLHALQPCASRFPLALFWRSILLTLFLARHAASARLHQDGVLGLASNIDQSIGSLLCSNDSRSTRCFISPSHSTIVLVDGHASSSANPSAAARVTPLWTYLLVSTSTLTLQPGLLPTWLDRPDWIHSPHSVSWILLPLVAIVRPLDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUB3</accession>
    <name>W3VUB3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUB3"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="111"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="528" mass="56015" checksum="364E4FB26364CCD0" modified="2014-03-19" version="1">MSTATTTTAGRTTAAETGLAATTVQRRPSRASYTDDSEAHLFRSRLGSLSQQDYTQPIDEEEEQLKHHFDDSKATSDAENSRPPSPPVLATYPPSQAKPAELAAVDQGAAAWRFLACGFVIWSMVWGVAYSYGSFQDYHEHNSDSPLYGTSVTGISAVGTLVIGCQHFIPLILRGFVTTFPHLRRRLVLVSVVLSSACILVASFARSIAMLIVFQGVLFGVTSGVLLLPVVLYLGQWFDTRRGLATGVIFMGSGFGGVVFPLILNALLTSIGFAWTMRVWALAQLVLTGTALWFVNPRLPLETPDVLPITKLELAKALLPGDLSWLTHPLSLIYLGVVALQAFGWYIVSLYIATYATALGFSSTVSTGILAAFNASAIIGYTITGPSIDKLSFTLGMAVSSGLCALAALLLLGFAATLPILLVFAIVFGAAGGGFGCFLTPIARDLAGVTRSDNALQFLTWMFIRGVAAVTGPLVGSALYRPSVVTKDPHAGEYGINGFNALIVFTGASMGVASLVALAAHVFRSKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUG1</accession>
    <name>W3VUG1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUG1"/>
    <dbReference type="HOGENOM" id="CLU_022876_1_0_1"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="433" mass="48264" checksum="3D59ED6C851477AF" modified="2014-03-19" version="1">MSGAASGSKRKAVGASSSRSSNGKKAKSVSTEGDASIPLGRALASTEKRTRDAAVRSLTAYLSANGAHTIDPLELGKLWKGLFYCFWMSDKPLVQQRLANDLANLVLVHPTSTEEAGEMSQRVMAGLTFLEGFWDTLVAEWAGLDKHRIDKYYLLVRRFVAAGFRLLAEEKWQPKAVERLAAMLGKWPGGALSTNDPKVPDSLTYHLSDIYLDELEKVIETVHDEENGQEQEEEEEEEDLPLVPTLQLLMPFVDALATAKSKAMYDRIWSNVFEPLLDDTLRASARDDDSQDGSEDESEQDDEQDDDQDDAEEEAGDETTTGTEFHSFADESTLTHTIDDDESEPSLASDSDDEDEEEDSDNDVRYPLLLALSSVPIPTDVDEDDEQLDVALVLRKAIFQALFTAASRKDATEARRRLLYQLWRDEQDRLNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUJ0</accession>
    <name>W3VUJ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_00337</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUJ0"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="15"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS65263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="385" mass="41274" checksum="39ADE44716C13EDC" modified="2014-03-19" version="1">MSVSQPQPGAAKAFKILVLQGDHIGPEIMAEVLPLFQLVQSRYSVAIETVERLIGGSCLDTHDCPIQASTLEEASTCHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLKLYANVRPARIVAERQLQLSSLKDDVVRGVNIITLRENAGGIYFGRKQEPDSQAMKASDLCEYTREEVARLTRVAAALSLANGADPLPIISVDKANVMATSRLWRQVVTETIRDEFPQLVPKLSHHLVDSAAMVLARDPRKLNGVVLTENLFGDILSDLASVIPGSLGLLGSAEIDAPPTLSSSGRLPVGVYQPVSGSAPDIAGKGIANPIGMFESFGLMCRWSLGLSEMADAIDAAIKRSLETGQCTRDVGGSLSTQQAGSQMRQWIEESLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUV5</accession>
    <name>W3VUV5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003947_0_0_1"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="4">
        <location>
            <begin position="452"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="SHQ1-like CS" evidence="5">
        <location>
            <begin position="1095"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="Shq1 C-terminal" evidence="3">
        <location>
            <begin position="1358"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1541" mass="164736" checksum="CD7C58279DE400A5" modified="2014-03-19" version="1">MDFTPSLRRKQTPVTYSRRNRQQGASSATSSPAAARPRPAADASHGSSDEAEEPLENGTPSKEAPVSPAKSSRMDPSPSSSASLSSSLRHPPNPPNGSLPQRPARADSPSSAVKARRPSSSSTLPAKRSASTSPRKSTSSPSKRLARSRTPTRPAKDLSSLFDAIEPTLPQPRSNPFARSESHPVVHLAPFEALDPASPINSPLQSPTLPHFGFDDQLSPGTAPISPSKRSRMADRMAPRTARPAKSKVDEIAEALSNSRRGSLRRTETAPSAIFDAHLFDRAAPNGGMQADTPMAPARPSETASSSARLDIDSPAETQSQDTSASASGARRLAGIKQTSATNAKRTYGLQRSFLADQAEENLLTDSTQPPAPNPNADTATRSIEDEIEAQINGHASKHPTKPTRVASSAASRLSEANAPAPRESYAELLKKWGEGADDIEWDESQDPTLNLKSITSLRSTGELRRFNDDLEYLFSGLDPAQNLSIRKSSAVELIRLLCGKPDIGSLPDADDDSDVDEESIEDPLASAQSAEFLRKLKASDLIVRLFDLFTGAEAGEGTDDVLDASLAVYAAKLLKTASYAEPLMRERSVHLHHTLVNMLLRANRASRSDRKDGFALLRLHELRQHKIASRPDRKALDELRAISRISKLFVAGGTSWTVRNLVVAACCSLIALPRRLWTEDTLGGLFAAEEGVESVAPSSLFHSVLETLVSEGNKAQQRLVDFAKGLELVAPTAVEAIPDLEAVDVAIRFLDKAMDLLYLELDRNLPASDETLGALQHLIAFAIEAAPLDLLSNTGKAANLGAGSGYVRSIETRALQVLHVLFKMLLDLSQVDANWSESLASSAVLQASIVRAFLLGQQSASRLRGSEQDCDDNSTRSPDVALFDDVVHLSLALLTNLLIKQLDKARDALEAVRLVPTCWRRRSCAAADACGCEGRLPALQLLARVFFQTRIAAASRDDSNAAYLSNSIATAIAQFGVGGAERLEACRTALAAELPSAHSTSNGVAVVGEDGLQTLLDAVDEFAVVHQAALDAGRVRGDEEAAGSDVAEDGAGTDEAAQVAGQDGANPVAAEAGQLIKELAQTLRHIFTMDGFATPSFEARQDADRLYIRISCQGTTGGTSMPNIAVEGRIFGFHLEPYYLPLVLPGAVRTPGSDATTVESAQDGATVFVVTLDKVQRGEQFEGLDQLQAQLLPEDQLKQALVDAEQSKGFFEPASQASEDAEAKSLLQQALRSQGLVTVTDNEGEAALDDEMVSTQQATVDDKANAPGFGFGLGGQARGALIPAGCADTRNVLEVADPGSMEPAARYAAAVAYEEERWDEGVYMDNYLDVDGELDHVLRFTPTVPAGDSAAEVGGEAQTEEALAVVLELLFALSYDERTNDGEATVESGWTIAKLSRSLSASSPPHSSGTLDAVVAATLVGCVRRALTVPLYRHWRLAQACIDDTLLRLRSERAHVISCLRQIASRLEAGDDAVLQRLQQLWIAPLLAQSPSEKQLQQLSQSIEAVRGRITKDTVGGEWDLEVVEQAAQQAFNDGEGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUV8</accession>
    <name>W3VUV8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003753_1_0_1"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="74"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="449"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1200"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1402"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1203"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1257"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1421"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1477" mass="159762" checksum="E1C4BF990FAEC319" modified="2014-03-19" version="1">MASIDMDASAAAASLDSLHSAFSKIRHHTNSKLENQKGPAQLLVAVEATLAEQDSTKGTTSATGAAASQHAAANRSPAEYFLALESMMEMAKSASAPSSLLSNVFYLLSIVAPHVSPGILRAKLSSIVPAVGKLLSTPHPTTFNVNDTTSAETYASTLKSALGILQAIYSAFQSDVSALETDVPLRSCWSATLNLCADSRPKVRRRAQLLITSILPTTAAASVKPYHPYLKLTFDWIISTLAHVADAGSVSSSKSKNKKDDPLHPKYDKKSGTAKQAQAAAALRQNQGDTASVGIWVCGFAKQMINILPLPQVDDLVAALLRLPGLQNPFLTVAAFDVFEAFLKACRPSIASGVAQADALLIQSHVTSSPSSIGEKTLASLLDSLRSPAFVPSSSDAQLLPAYLRALEHAVSAYSRFDNGAPAWRLAPQVWTDVIALAMSDKSDASRTAPAVRAAGRDCLIALLRYCVPDSAIQDAIKASFSKKKATDAPLLDMIQSLEDALGKDALQFMHARAEILSVLASLISRLRYHYVPKTQPPHPAAASLAMHIVQTVAELRQQTHFEHREYADTVIAAAVEVCGPRLLLEALPLNLFGEAEGPGRAWLLPLIRTKINNTELSHFSGDLVSLSEKIFTKRQEAENDARPVEAKMYEALTEQIWALFPAYCAMPRDLLSAFTRQFAELLTNVLYTQSNLRPSICRGLQALVYRNEALVSSGAPSDSLKHAFGLDQVDGKANIAHLSAIAPNLLAVLFNVFSQSPGEGRGFVYDTIVAYLRVMSPQDIQNTYLKVKTTLEQSLPTLSTKQKRNQKESTTTPPPVPYTMLDLISALIPHLDKSAGGPAADLFELICQDSVLRSHDSTVQKKSYRILSRLLEGDAGKQILLAPSAGSAKASNRVGELLDKLRESTASVALGAKRDRVLLLATLVPNIPSDELHHLPSIIPEAVLATKEVNALTRQNAYELLVQMGYKMEQGGSINRGLVEGHGAAAGADEEAEDDSEMADAGVVSASISEYLTMVAAGLAGTTPHMISATITALSRLVYEFKETLEQGVLDELLSTIEVYLQSANREIVKSAIGFVKVVIVDFNTTLIDSHLPKLIPALLGWSTEHKQHFKVKVRHIFERLLRRFGFERIYALTDEDNRKLINNIRKRKERAKRKKANAAAEREAGALGEDDDDEPGLAPRILKTKGGNDAFEEVVYGSESDISDSEDDDEDAEADNDRKGGTAAALNRNRQRKNGGDDDKSGRANRRRGKQQDEAYIEADDDDDVPMDLLDRSATARISLSNPNAKDAGRGRNKKRQPGQEASKFALDEATGRMLIDDDEDASARQGAGKRVSFADGGADAGPIDVEGAGTAYINQGRGVDGMSQVRGGAVKFNKNNKRTREAEREMELEQIALEEAQDRVRQVQSGKPAQADKKKRVKEAIGKEFRAKRGGGDVIRNGKSPYAYVPLSQVAGKKAGKGDNVSYTGKGDKSRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUY4</accession>
    <name>W3VUY4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUY4"/>
    <dbReference type="HOGENOM" id="CLU_377280_0_0_1"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="650" mass="69545" checksum="D2DDB44039EBCED3" modified="2014-03-19" version="1">MFSEEERLASFAIASSSTSASTAKKRQSTKAASTSASSTSTAWPHPVTARGAKAAGVPTPSVLAVHGFYHAPTPQDPDAVAHFLYPELRIANWQANDDPLARLENALPNNGWCRIHNSLSLAAFDDAAKMWFWQSPELLPTSSEMIQARKETFGSRWPYDGKKGWKPTSKKLAEAGFLFNPTEEEPDNAKCIYCDRSLGGWEKSDDPVHEHQRRHPDCAFFKCELRQPPPPAPQPSGPDADSDDAAAQDAEPVVAPRKGGKRAVSANARKASTRVAKAKKAASIAASAEPSAPPSRSESPAPEPEAVAEPEAQEEAPAPAPPAKKGTRKTTRSVSTRKGAAAAEKKEELEQDKAEGRPAPEPEPQTESSASADTPEDKPTKVARTKKPAAGLGNGSTEPPSMRPSRLASRRATRLMEMLSADDDVDRIPRRPDEDDLARREQALSDPVPFPRVPSEDEREPATDPVVAPKPKRSRSKSAKKVEPAPEPEPEPEPEREPEPVVVSESEPEVEAEAVPEAEPVLDTTVIEHAASDVSVSDVEPSPPRPVRPAKPTRSTRTSSPVAVLPPTTSEATIRASSPAAAPGVSSLAQLAALDLDDTQRALTLGAWLQAHADAAAREMRAAAQAELAQLEAGALRARGEMERTLRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV68</accession>
    <name>W3VV68_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250299_0_0_1"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="393"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="811"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="960"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1215"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1306"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="816"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1019"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1077"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1331"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1368"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1407" mass="151087" checksum="AD2EC9EAEEAFFFF4" modified="2014-03-19" version="1">MIDILRPAPSKARPSPQRPASPTLSPASSNSTLKASSSSRTKPDPASTSASAARSKGQQARRLSIETAVTSSRRYRYNRVRQPDQPLDLDQPPFRRSTFASLPSHHAKAARATAKDARSRDASLVAPSTPELRSSQRSSSSSSRKRSRPQKPLLGGLYFSDLIVVAFFYAVNLLRTCGIAELVDVAFKAFAYVCTRLPFDFYQRWSLSRPPSTQFASWTPLTNHPPPPNHRLRRELDDRSTPALTTAVTTSSDEESSSLEAFDQDEAQLSPFHHLVLLLVRFACTSFPHLVPRVLFAEETIGPLVRWRTGGGAAGIVREFTSDHTPTDRSPTNAETSTIQDAPKAHSKAKPKPHQTHTYTRPGFRAFWIGADAHVPVEVRRSDPSSRSATTFLYLHGGGFSLGSVAFYAEALIRIITKVCSLEERDNDARCVAVEYDLGPTSRFPGPLLQCLRCYAHLIEVEGIDPASITIAGDSAGGNLAMALLLCLDGQARNEPGLAERDWTSLPMPGKAVLISPWADLRPSSSLAFASLREAAAADARSAAPAASAAAAPRHKSTSSREQQKSAASGRVSAWTEAIGQHEWDYVAAEALMHFAQLYAGVLKTPRRVRGPMGWVANVCAVLAGDDEVVPESRTSNKKGAAASAAASIGATAPLAILRTLLVPSQRIARVAHTMLTEPLLHRTSTTRSSASSSDAFNQVEHIRPSAIGALDPIFPASERKTDPVPSTADLFVPLWDDSPQDEDKGQGKEHRQHDPEFEAACTLLESSKLVNPAIGDWSRIRLKRGMLVLWGDRERLADDIEAWIDTVRQAQSTRRTRDDRPSQDLDPSHADIAEGKHSYTDAPRRTLQERRAASRSPRRLAEEVREHAADWVCTAVEHGPGGVHAWPFVSMYLAGSDAEREKGLEIIARFVADPMLSPASTHPGTPASTVGSLAVELPVAQEHRPLSVAVNSPPHLNAVSPAGSMPSDISSRGDEYDYPFAPSSYTGSEGWDPSEQNELGLEGVYPHETVWTEPTPTPSTGAATPASSDAEAASIGHDELAHRIGLGLAEEARYRAEGSTRMEPVHLHHPMQGRTASWQQASSVQAAPAPAASRSQRDTGSRRGQPAVLGGPVAGRSLAELEAESDRSAPPSAPSSRPESPGWRSESVGYDSHDDDLGAASPLELDADSYFGARFSYADDVIPMDPGFYGLSHYHTLRPEGLSDIAEEESQMDTSSVLSGGPGAGALSPGFSNPSFSPTDGASPVVAAANPGRYGAAYTPSASEMARLREALDERERQYRQRFARKFGAPSAGQEQRGEMLRGRFAIEGDDAGSIVDESDGDVDSLDMNAQQAAEASGASAWRSSADRRDLAPTTKGEVARQGEAGPTTSGVAASGSSLVDEGTERAPSPSPSTSSQNSGARDVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVH0</accession>
    <name>W3VVH0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="3">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVH0"/>
    <dbReference type="HOGENOM" id="CLU_308625_0_0_1"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="215"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="934"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="955" mass="101480" checksum="C341C48390A6398A" modified="2014-03-19" version="1">MVPDTDFTAALNKPLEVVQKIYNDAQDKSSDSITKLVTAHFHQLFASADAKSKIPTLSAANIATLLPKPNADAGSSHRLVRFRAMIQDTGLGTEVFLAKHQQGDRNITGLFGGEATLPASESSADAEHAEPDHQDLAERAVMYAVSVPGQTEWAAQAHREAAAAGSSDSSVDELTNATAAVAIEEPQSPQKVEEVRQRIRRAVEKGKAIGSSGKEPRLVAISKLHPPSTILAAHRKAGQLHFGENYVQEMVDKAKVLPREIRWHFVGGLQSNKGKLLASIPNLYLLETLDSIKAANVLQKALSSPDAAKRDEPLRVYLQVNTSGEDAKSGLPPILSTDPEQAKESELLKLAVHVITKCPNLRLRGVMTIGAAANSSSADADQPKSVDEIVSANPDFERLILTRKNLVELLRKDADVAKADQTHVKEAYADLLEGSEANGGLELSMGMSADMDVATMAGSDNVRVGTDCFGRRPGTREEAMKGMKRELEVGPEAAAEELKGSSAPSQGGAASSSSSGADKYTLPRAFLAKSPIPEAPHVGGLVKLYDLEAAEKFKTTELVEVIGILDKASLPQAEWQETGSGAASSAEPAEVPCIHAVWASAVELDSVQAQESTGGSSSGNALAQSADRDALIAFLSGGLAGDKLAAELVLLATIARIHVRRANLCLGALTLNVSNFGAAGKTASSAEQTQLSRRLNMLLPAVVDVSMELASLNDDRKPLYARSAGEGTGLEAGRLQLVNGTTIVVNEGTMGEGQLKESGIRNIRALSSVLESHKLPYAFPYSEFEFDTDLNAVVLSQGKSFLPFDIHCPLSPEAGSEDLYSSSVPKVEAEQLAGWRSALLGARSLATAKAFEIPDSVSEHIQHEFVAERRKEQQEATDAHGGVASKEGALGQEDLLRRMSLVRLLAISHSEKTLTIERWNSAVELDKQLMQRVAAAQPQSQQTPATGSAGAGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVW3</accession>
    <name>W3VVW3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVW3"/>
    <dbReference type="HOGENOM" id="CLU_064566_0_0_1"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF10">
        <property type="entry name" value="DUF1115 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G14750)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="337" mass="37192" checksum="AE23CE3ABD3522BF" modified="2014-03-19" version="1">MASTRGHLLAPEQLASVASAIELVSAMWSGTDELEMSAADERTVQLLADYLQLGLDELATPRAQHIKDSIGDAVVLALKVGVRSEQSLVERRVRVNVEFRLRAQGWSMWTSTKEAPAWLDRDAIDRVNAILSTPTAQESEEEEEDVVASILARVEEVSEFLLTIPSATETEQEEVKEEPESTHVQRTWYYLPSLSTKSKRDDICTLASTSTPRLTGFLLAGKPGLIVIEHPLSTPSPTDSESQAASSALDAFWSTIKRESWSDIPSSHKKISQRLVEPSTGRAFSTFDDVTDWPELERAAERGRRSDLSKLIRWLDARGIAGTQCLESVLGVGSWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW55</accession>
    <name>W3VW55_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245347_0_0_1"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1415"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1623"/>
            <end position="1647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1656" mass="173388" checksum="DAB8605913E506E5" modified="2014-03-19" version="1">MTVSYVRSPSFSAHSAFTDFHHASPPQSPVASCASSAVSASPVLGRGSPNPTPAPALAPAAPASDSVPRPTAHLSSSISSPAALSIGVDAASIVIPNDRMEAGLSLRRSPLLLGSDFPAEPRATEADASSNGESYESALTGDIDLHDRFVLRRPYVDRAFPHSKRRSQLILEQKFNQHRSAAASLSSTSEDDWNHTSTLVASSRSPASRRPGTAPHRPPVSPRTPDSASASVLLDFSGAKSPVAAGGLRELTIGAAAQPASKRASWTRLARESEARSDSHHSPNSSLLEAAAPIQPSAATSRRHSSFLTGDYRTATLMPIFANKSFEIPSPRADKRRSEIVQLPTSSDADQAHSPNLASISTSKRDSMLSTDSSATSSSKGEARSSTDNVEFEGDDAQNQAQSSASSGYGDDETIARKTPLGKPEASKEAATNVAEVFTTPRTSAEHETVTKSVPSIAQSDKGETVQSLNSAARSDASHHAKLSEATAADDNGEPVPAPAIVPSALDPLQTAVVPPTPPEPRWTPPNGESVSPTSSPSKTFRSLDALGESPRSRRNRSQASIERRPSDTPTSPSATLSIPSAKSNGSIVGAGRRGSSASVASVASSTSTYRIRRKPVPSDGGGDADSDVLAVSPQPSPAQQEAPLPSTEEEEGTHLIQHARTPSGSDFMRKAQEAAQAHMLAKKAGGSTPAPPPAKSSKRPSTALAATGASLKPGLGLGKQPFASASVRDLKDANGSLTASSSGSGPGGPGAGASRPASRATIKRPTTAPVGSAGQFRVASDATSKSVLEVEGLQFVLGKDDAAKAKVVLDGSPSVPNAVRFLQHQRNGSTGADAASTGHNSLRDSRRKSASTHDSHHSDAVSATSGGLKATSAAVAAGATPNASAGGWGLEEEIKIADRVKGSTQSVPSPKPRPVSMDKGKKSLDFSAKSNLKNSMLMNIINEDESDEVKAAAREAGIPEGSYAIHPPSMLQLFEASQCLVYDQTGKEVIFGDLFKRRRTLVCFLRHWWCGFCQQFAMSIRHIDPLPLKKANMDFIIVGQGDWSVIKAYREVMQVPYPMFADPKRNVYRALGMTLRTNDANPVCARPDYASMSMTKGILVAIKKGLFDMPIRNPGDMKLLGGDFILGPGLQCSFTHRMTTADGHMDLPRILAQAGCDLSLKTPKPLYTVDEKEARAAMLAGGNQNRRQTRSLGRSRGKKSSKADAAGLDGSFGTTSGAGAAAAAPTGSATGSSRFARPSIWGRFPGRFSKSQASLPMSESMADLSSDFGPARGLSAGPRSASAMRKISYDGRVRDSFETQQTDIEFESRATSIDTRRRPSDVSMPSGAFGLNKAQSMSELRKRFELGGLRSKSRQEPSKAKASLESHLTVPRGGANNLHHSVSTKSLRKEEGSGAVTPNGAVTPTPPQPPPKDTPTTPKESTPAPKQLSVFQNRVIAKADDAAVPATTGLGIATVGDAAAAVGEDGVTENGAATPKDGTPLAKSIAELSAPGSFLMDLDVYDSLSRQPSQKFYGKPKANGNGRLEAGSADSGLSPSQFSDGGFGQEAADADSDTEPSMSANASPARTQKTTPSSSSSGGSLGPSASASFYSFNTFRGKTNLEHLPEEADEDESDASRRSRDEDSDEDSDEEEEDADEEEDNDEPIQFEDGRSGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW62</accession>
    <name>W3VW62_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW62"/>
    <dbReference type="HOGENOM" id="CLU_434195_0_0_1"/>
    <dbReference type="OrthoDB" id="10263761at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834603" evidence="2">
        <location>
            <begin position="24"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="630" mass="69093" checksum="506B57650D434BF1" modified="2014-03-19" version="1">MKLLSIVSLTALSLAVAVPSTGAAPVPNVPWNPESRGNQVAAWWDSYLSSAASRQSLGPEDIWRSSRDELSQHLDAFHQRLNQLDYLKRWVLSNKMTRSALTTEQRNTLAKPFMPWKGKTLSNVYANRHGKARASYGSADLGLLPKKGSADEVFVTYYAEFEPWIPNLASSLCALLAVAMLPLLPPALCTSDSEDESEGLDLSLRLGQRLEHHDAASLDSPATLASGSSHSGRGSTLHELTQLGHVPAPPSLYESQMLNRMQQAAAPSEASSSMSGFPRQDADRRIEYDIAPMSWKRYADRYLGKPVPPFIVGGEFHPQHAIAFQQRILSLNTAKNNLAEGPQALPGLKGKTSSLSILIRINTGTRSHSARSEPQKLLMMRLAVLSFLLAISLCASAPTGGNVDLTLRLGPASTPQAASDGSTPTDLTLRLGPAYTPDSPGTSDSSTSSGEYVAEHPVLALRDGQLPKDPTFIPAEGSIRAAVQDLRGASSRRLFPFIPRLRKVDPGNLVGPDVRARRLWEYYTRYHLNTPVPAVIQDGRFHAQEALLLQRRIESLVRAKTLFIKLNRGRSFSKSEMGVLTRRFLNWRKVTKNVASSRASVFAPSNLRAKVAIDIQTLQRDEELLRRIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW74</accession>
    <name>W3VW74_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein beta 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW74"/>
    <dbReference type="HOGENOM" id="CLU_022731_3_1_1"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="58393" checksum="3E8BC6D2961D7C59" modified="2014-03-19" version="1">MLADAESPSEGSRTAAAIESEYPTPPELSIAAWRRRMSEQTKVTSPHLLAQLDRPALCAISPAGDSKGTTARRSRPSSSARTRSDFYRRASWAPDGSVLLAITESQRNHILGCYASKADDPSPSTSTDGCRGAVELLGETKSPSPLLDAIWYPVPALDSAHGTSEESGAGQTESAAVGMTPTMTWCFAESHRDLPTRLTASSTGEARASYSIMNHVERFVGPHALAVSPDLSRLYCGLWSALAVFPLSRPGLNTHSSLPLVAGKRSRGGQRGIVSALATAPNPANPTHDLVAAATFSGSVGIYGFDPAAFPEPAEHTARHDEDILAQTSCLAGWSEIEGDGVTQLRFHPLTPYVLFVASRRSDHIYVYDIRYLMGDSARWSFRPLSQPATGVRSAHLLAKLHRPGGASAQRLFFDIDWAGRWLASGDDQGSIHLWRIDTGRFTDSDDAAGQAEIAPDLSWKAHQDAIGSVSFHPHQPWLASVSGSRHWPEDEGNSSSESDRDSSDSDSASASDSSAGSGHFRTWQTRDSSLNIWDFSDPDVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWE0</accession>
    <name>W3VWE0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Epoxide hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWE0"/>
    <dbReference type="HOGENOM" id="CLU_045011_1_0_1"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS65147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28642" checksum="5725A7C20C7BB545" modified="2014-03-19" version="1">MPFKAVIFDIGGVVVGSPLFAINRYEKEHGLPFQYLNVAITAQGRGGAFQQFERSELDLYTFYRRFGQELSDVEKNNAAFTKFCQSRGQEVPKLPTQLKVDGRELFGQMMRTSTTVDPKMRTAIMRLKVAALTNNFAPPTEVSASAEGGGGKAPSLDEELQHLGLGSSQEQLRKLFDFYIESAVVGKRKPDPEFYEYALNLLKVKPSEVVFLDDIGPNLKAAQKLGITTIRVDSSDSTPALAQLSKLTEVPLLEGASSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX75</accession>
    <name>W3VX75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004351_0_0_1"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="330"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="569"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="849"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1134"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1299"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="861"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1179"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1310"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1338"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1351"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1415"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1425"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS65391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1489" mass="160480" checksum="6D556DAF2DE51B48" modified="2014-03-19" version="1">MPVPSTTVTTARPADAVAQNGLSSNASVSARAPSPARLQPDAAAASPRRSVSASSSHSSTSNNSARRPSAARSEASAKLKATLSAAASSDRSNAAANASITDQRLPSSAPVSSSASSSSAPPPSSAHNAVALDDTLANHPIHAFRADPANLPAMPAQVYATQSAAQSASPSHVDSPANGYLPPQMAANAAPLLTSPSRSAPLPAMYTATSTSHSTPSASPNGRIRSQTAANAASPHSSGYTANGSNVGYHGSRSMRTSPQMRAFPHHAHAAIPNLQGMGSSIMAPPSAPSSVYGGGANANGHSTMPATSPGYNQAQSGPQWERHTTELTNCIVAFLSPILPTEEEYRIKEATRRQLERLANRVSPGSKLLAFGSMANGFALRNSDMDLCCLIGKGPDGQPTTQHTASELVEILGQLIREETDFTVMPLPKARIPIIKINRSPTTDLPYEIACDIGFENRLALENTRLLLSYAMVDPTRLRTLVLFLKVWTKRRKLNSPYMGTLSSYGYTLLVLYFLTHVKKPAVLPNLQRVPPTRPMKPDEMELNGNNIYFYDDVATLRKEWSSHNTDNVGELLVDFFRYFSKEFSYARDVISLKSENGLIPKDGKTWNAELCIEDPFQAGYNVSRTVTKDGLYTIRGEFMRASRFLTNMRGQKISVLIAELCEEREDSLSRAPDGPGSMQRYPYNAHLGVGGANGAGFYGSHANGGRHYRDTYGSHRRYDAPNMSGYGGSFAFEQMARGLSQGVAYPPTAAMLAPLSRTHGLSPKPQPPRFGAGTTNAEGAAAFSSAQSDSGAYAPLDFTRASIGHASARTSPSFKHAVPTGYASANGIGAQEAFAYGAEISFGAPAPASTRDDLGSTPRGKTSRSFSETLNRSKSLPRAAALANGHRPPPAGHVGAGSSTGLAPASATPTSVSFDHAVLPAELESRMATLSVQQAGPGGRRLSNSSRASSSAQFDSSVSMQCSSASSPWSVGHAAFDAHHQPTDTHALVQEYLRRAAQLGTDITLPLDAEKGDEVEAEGSVISEATLDELARLSELEDDELHWRAEEEGAQARRKHQHKVAAAAATAAATSGIARKDRENSAAGRRVVASDEELATPILTDRGSAFGAWADVGLQQLNAAAEPSRVGVDREARIVDSSHTPRPTHKRVGPLPIQWSSRPTSAGGGASKMPRERSRSRSPGSDPRSGPHATLLRYGVDEIGEDDYYVRSAEFKAWLADTKRKYLDEISSREARRYFERFIRRWNDGRLPDDYYKGTIRSAAASAGSSSQTRHRWGFTSKPTYTAAEQEQLAMVRDSVDTLTNSSTRGAVEARDAERRVRRRTQEEAEPAPVRDSGWASRSNPGKTSADAQLDREHAADMERVARSQARQRERHERQDEDDSLHGRASGRERMLEKKRERSAAHRDFAERRAADDGIEMDDRDLYDDPKPQQRASRESTNRGPSRRDQQQQQRAQERRADMDEKVSALRAKDAKTMDMLKALAAERFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD26</accession>
    <name>W3VD26_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD26"/>
    <dbReference type="HOGENOM" id="CLU_625727_0_0_1"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="223"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="438" mass="47960" checksum="714C3B4500AF196B" modified="2014-03-19" version="1">MRTHASSSSSGDTQAGATSPDAINRSRSRGRASFVGASAEQLPRHSNRSSSRASFLGRPRQRVYQIYNDGETDGAADGQQRWRSESRTVRGSLEEDDGYVFTDDDEPQHQRRSDPHKTRAEAKPHKLTSTAEEETASRSGHTTVTSNSAPVAAAPVDPEKIPQSAQGANHNKPAADVEAQQKPAKPVSRLSRIPYPIAHFLGYRRKTTEGRALIRPAEKLPRKLETLLWAWIGAMLGLGFVMITFSRWDQFAMSTNDPVTAWTAPIVIGSFGASSVILYGTPASPLGQPKAFVGGQFLCALTSVCITKLFELNSKYNPNLIDSSHSLVWVAGGIATGTALCVMILTDTVHPPGGATALLAATSPPVIKLGWRYLPVVLLSSVIMTVWAMLWMNLGRARYPHYWLWPVGHPNDQRDFRVKFPGFETVKKKRETRSTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD60</accession>
    <name>W3VD60_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD60"/>
    <dbReference type="HOGENOM" id="CLU_085828_2_1_1"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="210" mass="22578" checksum="B236D6D2007C490C" modified="2014-03-19" version="1">MSTSAPRIQALAIVSPRGGPIYVRQFGSAPSSSTAADLRYHYFSHAALDVMDERTALATAPGASSNRTSSEQYLGLLSTLEDLAIYGFQTCAKLRFLLMISLTDHAVRDIDMLTLFRAVYTSYLKYSANPFHSLPPTAFARAADSNNEAAVAQEELEQRQASNLPINCRPIRSSAFDARIDRIVFGSASTAGAPRESGSAPRPTAASAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDF1</accession>
    <name>W3VDF1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDF1"/>
    <dbReference type="HOGENOM" id="CLU_1245843_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="222" mass="24058" checksum="65D27806813A70E1" modified="2014-03-19" version="1">MMWLSSTPADAQHAHPSARPPAATAAHQAQPVGAQPRSTAHPLEKTKTNVTDRHWTDCGGCVQDGKECVPPEANTKRRCQQCREKNRTCNCSFWMESDAIRLYDRLLDLGFTLEQIDRRVCGASPPGGTLDKCKTYDFRGDDTDADDDLAPPRVGPTASRSSRPLVQGPAAATCNQVAGALTDKQKSGSLDKISNAFIMKLVRAANAVQTSGSENGTENYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDL8</accession>
    <name>W3VDL8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDL8"/>
    <dbReference type="HOGENOM" id="CLU_047270_0_0_1"/>
    <dbReference type="OrthoDB" id="3366645at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="349" mass="36573" checksum="1C6F43D6A7D35940" modified="2014-03-19" version="1">MAITLQTVLPSKVLPRAPSPNSASPNPGVRSSITQFIPASPDASLDRDAFATSSAGPNALDAPFTPGGSQYAHTRSRGLSTSSNAQSVYSADSGTAGLKSPMSPIALGRKSMSAGAGSRRGIAHSIRVLGVDRVADVFDMAPLSSGQVDVSFEATLRAQPPSGKGKNRARDPLDDTEAQALFDVDLESGQPALNQSRATRLLQLGAQSMPWSKSRARTSTDATPPAVPSSLPRSLDIPREHGGLSDDEDKQEGGIEDEEGGDDDRQHLLYSGGETDRPGFFAPGDRSFGYHTLGAAPGGYGGRVGFEPLLWRERIWMIISACLVAVVVVVAILISIDVIDWPGDGIGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEM1</accession>
    <name>W3VEM1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEM1"/>
    <dbReference type="HOGENOM" id="CLU_144328_0_0_1"/>
    <dbReference type="OrthoDB" id="2550823at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="174" mass="18505" checksum="4C70821C7A7FF37C" modified="2014-03-19" version="1">MAHPQTAFAPQQSVSDFSALNILWLLHAAIEAPVAFIGLFLTRGLAFKDEINNTMSIIIKMYATLALALSIVCLLLYGLPDYLPGKRAAAILLLLYHGVASSILLNAEPFVDFVFPEILAKHGVRVETVFGVAHGILSLLTVSWWQASLGSVKAQGSGAGPAAPAGRPKGAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF70</accession>
    <name>W3VF70_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF70"/>
    <dbReference type="HOGENOM" id="CLU_544139_0_0_1"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55858" checksum="F8612A1B4DFA0626" modified="2014-03-19" version="1">MSIPGKVGTFFAGLAGKTTHSKLGFKLLASDPVLDTARNLGFKVVEYDVPPYPLWTAGVIAVRMLSFIVGSAVVAYILYHNVAVKSKAGKWFSIVSLISTLLAWPLLTGRSGVMLLDFWRPALGFRSSLLVWDIFHIRTHDEVRSWSFARFFAQLWTFPKELDDLAERAKEEGYERNARWENLKGMPKVAVEAVAMFGTLYFIPPFELTRNMSQLAYHGYCDALGLCILMALALFGDGLLKALGILINVEMADMFENPLGTTNIRLFWSHWNRAIATVLHRVVFGGGKSKTVIRKKKLEAEAAAKRRFSHMDGMSETDAGHTSGEDEQAHSNGGRRRNASGLKPLSQVADGDAQLRNRKNGKTDSKANGSAAPRTGAPAKKSSFAPKAAAAIVTFAMSGIFHEHITYFTLGFANGENFLFFLLNGVATVTATWFKRTYPELNDKIPTWLSVIMLHVFFVSVIPLFCSPFIRSGFFVQLEALRYELMPIRDRPRGSFIYLFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFU1</accession>
    <name>W3VFU1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_06530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFU1"/>
    <dbReference type="HOGENOM" id="CLU_055068_7_0_1"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="249"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="406" mass="44218" checksum="C9E0ABB2CFD1CACA" modified="2014-03-19" version="1">MKPSIRSWAARSCKLSGTTPLTAASAARAAASTSQRMQLRRASTRRHADQGAACSSTLRFDVNRFPAPTHPTAFRGMSTVASAEVMTRHLATAAGGRSSGLFRSFCTSQPSVPLQAAPAGLGIAAWVWSRMPRLRSESSPSRSSLRSRNQPSPLFRRPSPNSGGSGGSGGDPRRRPGPSWLASFTARIDERFWSRFDARAVILAVIGVNTLVFVGWAWARENMQRFADPRAMITMSKNFLGGEINMREGRWWTLLTSCFSHEAPMHLLFNMVTLGFMSPPVVALTGPTMFLVLYCGGGIISSVVSMVGKRVFETEEQRRRRPFSHGASGSVYAIMSTFACVQPRAQFLLFFVLPLPAWACVSGIFAWDVAQAVLNPGQRTDSAGHIGGVMAGILFWRFGLKGIQMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFV3</accession>
    <name>W3VFV3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFV3"/>
    <dbReference type="HOGENOM" id="CLU_1210272_0_0_1"/>
    <dbReference type="OrthoDB" id="2553803at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="229" mass="25136" checksum="F010FB40973DA5EF" modified="2014-03-19" version="1">MSAQNIPEGTYRISFMDGVLVGLEPNHPLRVLPEEQSERSEWQVKKHGSDAFVIVLKKNDKLGITWSGDLHYGTPLLLAENPAPFKVQQQERDRYDLVPAKDEQLEVALSPAMIFPPISNAPGFRARHASRSACSDDVLGQQLFAAGLFNLPSLSVSSSLSSRLHSADSLGLLLPRDRARLSIVLRRIGSVPNVSPSSIESQVVFDLQPQHLSSSLCIHTRRHADATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG82</accession>
    <name>W3VG82_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05431</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG82"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_4_1"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="179"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="385"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="551"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="590" mass="65279" checksum="317DD5982F2C130B" modified="2014-03-19" version="1">MDVFRKLAGGGVSFDKKRFESDVKIFGAPDEPVASGSANKHKRKRSEPKAETQAAKKDAAKVVVPDGLDFFGSAAKAKATVSAVEREERQSKRDGKQKEGSDSEEESEESSEEEEDAVTKATLSAFLKRNRIKLKGTDVPLPMASWAELESRFGVAPWLRTNLDKWGWGVPTAIQKGAMPVLLANRDLLAGAPTGSGKTLAFLLPLLHHLRAPSKEGFRAVIVSPTRELAQQIHDQMRRLSEGRNLRICVLTKPADAGAMNADPSKRKKFDVLITTPLRLVHAVEKEEVDLGNVRHLVLDEADRLLEDGFLEQTDAILAACSHPELRKALFSATLPAGVEEMAKTFMVDECRVIVGTKDSATETIRQELQFELQFVGSEDGKLHALRSLMQAGGLKPPVLLFVQSIERAKDLFHELVYDGLHVDVIHSERPKLQREGVISAFKRGDVWVLICTELIARGIDFKGVQLVINYDFPQSVQSYIHRIGRTGRAGRAGRAITYFTKDDAAYLKTVVNVMRQSGCEVPEWMLQLKAPNKKERKKLKAKAPERKDIRTVAASSIGRRQANKRKDMIAASKRRKTDAQAGAGAEKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG85</accession>
    <name>W3VG85_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oxidative stress survival Svf1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG85"/>
    <dbReference type="HOGENOM" id="CLU_030205_3_1_1"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="142"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="319"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="57645" checksum="EE0217F7A18C37E0" modified="2014-03-19" version="1">MAAASYKRGSNRNTCTASASPLQRASCYRCQRSWLFLWTRFCAPSTIFPLVQLAIEPFESRLPSSFTASPPLDSLRRIGSIHTMSGWGSWLKGDSAAAAGSGAPAASGSNFHAITDTVSQNALFGPLQASDLEWTCAGGFTTETQTWYSFLEDGSFATSQIIHSAVGLWYPQVQMTFKYFNPKTGKKIWKSVNVTKFAAPPSAGAAGPQGDKRSSKAAEFTVLFTTTEAGEDKYTITANLDADLQLSWSFVRPAATQGWKLGAGPKGGFSYFGSNLGSPEGYVIHRFWPVAESEGHIISQGTAIDAKGKGMFVHAIQGMRPNLVAAKWNFANFQAQDDKLGRVSGIMMEFTTTPDYGSVAEGANARESLTVNIGSLVADGKLVAVSAATRSAGSPASEASRKSNSFARHLDPMLDQDTGYQAPQAIEFHWQAPLLDSASGKGDVDHKVEAQLKVDLGKPYPSSETHGLVDKVDVLAEIPYMVRKLVNYVAGTKPYIYQTLNPATLTLTLPEQYAGAGKGESTSIKGTLFEEHTFISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGA3</accession>
    <name>W3VGA3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1295-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGA3"/>
    <dbReference type="HOGENOM" id="CLU_043418_0_0_1"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="48945" checksum="90E4E4983EE5D272" modified="2014-03-19" version="1">MTGTHSLWEHAAIDPNTHLLPGIRSFWPAFTSYFHNGKALTHLATYKSYYASADPLHSAIAFCGFVSFYVWLMERITGNASQVDGLWTFLPLIYSVHFTVHKYFTYQPAKLSLFGGVESASLWDKVEPRLALMTLLSVLWSVRLTYNAIRRGMFKPGEEDYRWPLLRKTMSRPMWHIFSIFFIAIAQNILLAITALPNYLLLTTTSVKHVTEPVPRPVNQLILGDYILAALFVLNLTIQFFADQQQWNFQNYKRGKDPYEKPLPAAMLDPKSKLPVKNQTVQPYSTPDDARRGFVTKGLWAWSRHPNFACEQTTWWILYAFVPLTFLPRNLDFTHAHWSHFANYAILAPLAMNALFLPSTRYSEQVSAEKYPEYADYQKRVGMFLPIDTLLRTLYYNLIASKQDKHRVEANVWGTSHISKIKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGN7</accession>
    <name>W3VGN7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione hydrolase</fullName>
            <ecNumber evidence="8">2.3.2.2</ecNumber>
            <ecNumber evidence="8">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="8"/>
    <dbReference type="EC" id="3.4.19.13" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGN7"/>
    <dbReference type="HOGENOM" id="CLU_014813_4_0_1"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="488"/>
            <end position="490"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="540"/>
            <end position="541"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="664" mass="71449" checksum="72EC493543F16BB1" modified="2014-03-19" version="1">MASRASPRPSSLRSSASTSDAIDPIQEEVVSTDGHVSAPTERSPLLPHPAPAQSAKPRLARNPILVLLAIFAFAVAMSVVLKTLLGEFDDASDGDGDTGHPPGTDPRGRRHPAVLATGRKAGVATENQLCSQIGLDVLLEHGTAVDAAVASTLCVGVLNMFSSGIGGGGFMIVRDPTKCYGRDAGADCAEHVTIDFRETAPAAANKTMYVGRVPRAQFGGLAVGVPGELRGLEEAHRRWGRLPWKRLVQPSIELARSAKVSKELARRLAYFGGFMLDDPVWREVFVNPETGELLKEGDSIHRHAYARTLQTIADHGPDAFYTGPIAKRLVNTTLQNGGILTLDDMAAYKVIVQPALRGSWLGKRIYTTHAPTSGPVVLSILNMLSLIPEFATAGPTSVNLHRFVETLKFGFGQRTELADPDFVSDQDRERMAEIPTMEEAQRIVPNITDDRTHALDYYHPKFDIVADHGTMHLSILDAHGMAVAVTSTVNLIFGSRVMDRETGVILNDEMDDTSTPGVPNAFGLAPSPFNYPEPRKRPLSSTCPTIVESEDGEVELVLGGSGGSRIFSAVLQTLFNYVLWGMDLSQAIEAPRLHHQLLPTQLSVETGYSNKSLAGLLGRGHEVAWLDIDLGVAEVQAVAATRRGRHRKVFAASDSRKGGIAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGP8</accession>
    <name>W3VGP8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04627</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGP8"/>
    <dbReference type="HOGENOM" id="CLU_037637_1_0_1"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="156"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="320" mass="34721" checksum="B22713EAEB91D3FA" modified="2014-03-19" version="1">MTSKDLSLEELKDLQKQLSKLATSSDSEAILSVFSKLKSGLSAPTEDVIRQSKIGVAVGKLRSHSDKKVADQAKALVKDWKATVDKQRAQQQSSTASSKPSSSSASPAPTSKPADAVAEAEINGAAAAAAKSSAPPASAAPASTTKIDFEILQDKVRNACLKLLYQALEIGKEQHGHSDSQVFDAAVAVEAAILANQGKGSVTADYRNKVRSLSLNIKDKNNPDLRVRVVERDIAADKLVTMTNEELASDKRKREIEELQMQNLFKAKGAAAQEAETDAFQCGRCKQRKTRYYQMQTRSADEPMTTFVTCTNCNHKWKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGR1</accession>
    <name>W3VGR1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGR1"/>
    <dbReference type="HOGENOM" id="CLU_2004876_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="124" mass="13215" checksum="F66256A285E84832" modified="2014-03-19" version="1">MPSKPAFARNGKAPASPSGRRSPEPPSANTATAQLGIWLGMSMCTGAKMSSVLCKIASSSAWSLFASARVVTHHCLRRSGTRPCSTRALSSGPCELNRDLDEIEAHQSQILDAIRSDETRRFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGY0</accession>
    <name>W3VGY0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM-dependent methyltransferase Erg6/SMT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGY0"/>
    <dbReference type="HOGENOM" id="CLU_039068_5_3_1"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000232">
        <property type="entry name" value="Sterol 24-C-methyltransferase erg6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="4">
        <location>
            <begin position="47"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="347" mass="38803" checksum="82A71CBA2D2DA187" modified="2014-03-19" version="1">MAPTATDVRNNEGIANYTKFWQKDSKDDSATDMANRLSEYTSVVNGYYDGATDLYEYGWGQNFHFARYYPGEAFMQAIARHEHYLAHQMGLKPKMRVLDVGCGVGGPAREIARFADVNIVGLNNNEYQIQRARKYTEKAGLSAQVEFVKGDFMKLDEQFGENSFDAVYAIEATCHAPNFEGIYGQIQKVLKPGGIFGVYEWCMTDAWDASNPEHKRIAHGIEVGDGIPEMRSIKAARDALKTVGFQIEHEEDLADRGDKIPWYYPIAGSLRDCQTVWDYFTVARMTKIGRATTQTAVKVLETLRLVPQGTHSVGESLVTAADALVDGGRTKLFTPMMLFVCRKPASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH54</accession>
    <name>W3VH54_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH54"/>
    <dbReference type="HOGENOM" id="CLU_336823_0_0_1"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="608"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="689"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="89791" checksum="4137E90D6E45A165" modified="2014-03-19" version="1">MTTLAPDPFHRPAMPYPPSHPRHYNGEPSHSQPSPSSQRLLSQVLPLQDPPSSSQMQLHQNSIADSSATAHGSSSASFAVQRAALSLSSNAASSPPTTASQLSHPPPPPPPPPHTPSHSARATPQQKRARLHYDFGASPTSTTSALPPIAAAFLVSPNTLTTSSTATSAVRPLSGIARPLPMPPTPMPPQRSPRSVNSNQPLQPLPQRSVHDFEKLIPQRRPPPPIANGRVGPQRALLQAIPPQPPPVQPAVHAPAPAPDRRPPPPSIETLPHRPESLLTGFRSLDLDLDRIAEIASLEHFHAHNLPTSHRGPGTDSPQWLHTSRGLPSGSIIEAIGPPGSGKSSFVVQTAVTERLRSLARARRSLEHQDSDEHNSQAETDRQHPPSTDAHPHAIFFTDDFWDAEVASADQVLLIDCEGALTPEKIADAAWSTVASLWSSVEQRTPLNDATGEATTTAPDWAAESRAAMPEVVRRLVAAVLAGIHINRVTSTASLVALLISLRPTDELQDGQALPCSMPSRTSLILIDSLSYHLRLSGASSSDRKTNQQLSERIRDMLLRLQKPFEHRPKPDLGPEERDAARRRASQAAQKLCLPTIIFTNQMGMRRDRAELESSGRNSPSGWAVASPGSRSFRKNAPRGDGPSMLAPLLNGQRPPQPATIRDAPPAPSVALCGPEMGEDGEALLLPRMSQQARSRASGQASPQLGHDRGWPPSFLGQDVWRILLFRHGTAGRRFAQIVSIPPAVQSELSELWVQTRARARACASAASGQDADTSTSSNDGAQIGSDANPAASSTSAEEQLARDKDQRILELLAQLRTSLYRWRPFHVASAGLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHB8</accession>
    <name>W3VHB8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04836</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHB8"/>
    <dbReference type="HOGENOM" id="CLU_543045_0_0_1"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="180"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="304"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="405"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55192" checksum="64B85BF0C7096D62" modified="2014-03-19" version="1">MHPAPTDWLSAQCPARNRLAGIFARLLTQRIVPAEASLGVTTAILSSVFPSYLFPTPASHFHHTGPLHERFGAQEKDRERRRPDRRRFCSEFSARLPSLHKTAQLHLRSTLFRCSRASKRPYRHLHLDVTTDSFLTIHHPASRILAARNQARTAHPPSLTSYFANSPAQYTIDTMAEAPLTPFGQALAGALGGVFSNAVIYPLDTVKTRIQAGQSSAVTPGKEVRDPKDPTKTIVTVPKNVGMIKGILHIIHSKEGAMGLYKGFAASMVNTFTTGFAYFYWYSTVRTLYQNRLAKRSANGVAIMSTAAELVLGAIAGALAQIFTIPVAVIATRQQLATSETAKDGKPVDESFMGVARDILKEDGVTGLWRGLKPSLVLTVNPAITYGVFERVKTIILATSVDGKMTPGKSFLVGALSKTLATVVTFPYILSKIRLQAKNTRYTSAIDCLTQIAKEQGISGWYQGMQAQITKAVLAQALLFYFRDYFEVWTRQILKVAKKPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHE3</accession>
    <name>W3VHE3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHE3"/>
    <dbReference type="HOGENOM" id="CLU_045030_1_0_1"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="427" mass="47651" checksum="955C71D22B443A56" modified="2014-03-19" version="1">MASALSGAISVLILGGTTHLSRPLLKWLLDPAQDAARSNVEIKHIRLGDKFLASNGTSTTYIEPDTWEALKDPRVEYRQVNLNLAPNLPKVYDHPDGGSYDVVFDFTGEGVGQPDVPEELLIERTAKLAHSIAAESLRRNVKAHIRDTVAFLTIDPSSPPATEADIVKPKTPRAYWWYEAERAAASVPGLPLAITRSAEVVGPYVFHASIPSRYALGRVYAHLNETYKLLWGPDLRVHTIHVDDWCPAAWKLVEFISSRSRAEADQQAGELLPPVRMKDKLQDSLREKVGEECCLRTLTPRAPVFNLVDDTDLTQGKLLRMIGEAFNIQTGFTNAVINAWARVDLASIVDDINEKHANAIAEIVQQTGIEDVALKGWVDTEMLANRSLALSNAKVKRVLQWQPKVQVNRQRLEEILDRIRELNQFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHF8</accession>
    <name>W3VHF8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHF8"/>
    <dbReference type="HOGENOM" id="CLU_1741366_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="150" mass="16525" checksum="3C126BCA944CB125" modified="2014-03-19" version="1">MFRGINVDRLELEREEEEEKEEEEEEVGSDASYAEWKWVDSPWRPSGPAAAQHDPRAAFERASRGQTEPVNKKLHSLHQQRLVCLVFFERLDAVPSKAGGGCRLFCSPSGRRLVSWLSAPSSKQTEAGVGDPEGLTSDLQRDAGSTAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHP2</accession>
    <name>W3VHP2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHP2"/>
    <dbReference type="HOGENOM" id="CLU_1220143_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="227" mass="24479" checksum="C4713DA7E172FCD1" modified="2014-03-19" version="1">MHAASASGPASSFALPPFRNSPDSTHTHQTFGSRLARPAVPRRRLPWSTNPRPPISSRRRRHKGPPSPKNAQIASCKPDPQLAARVHRFLSCICAAASFPVMLGGTTVVLHFTMQRYSDLQVQSLPKLQLQPGTSNLPAKLSRAETVHPLFRPPSSAIPSAAAASSPTPPTIPQSLCQLASSSSSSPHPHSPAYRRSPPTFAITPVRLITNITFFTPFRPPSPRVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHX6</accession>
    <name>W3VHX6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHX6"/>
    <dbReference type="HOGENOM" id="CLU_387893_0_0_1"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF128">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="334"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="698"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="760" mass="79672" checksum="7BBA9B79994E9EF9" modified="2014-03-19" version="1">MPGASQILSCRPAWPRSEGAAARHVAESHSTVLLRATRPLRNSASCRGSKLTHCFLGLVRARSQGFVAGIGELAELLPLRKRHRAIFAVTQIGINAPSLSPTSGSAPDRKDAGLGSHNRTIVMALSQTRPISIPTPSSPSHSSPRSHFRCSSDAGSDLSISFPLGGATTFPLSAVQDPFAAVELNHRLASLTAEDVLSCDSSTRSRLVVFPHDGSIELAGERLAEADHAETWILLERQPERKHTRDTARGPSKLTTSNCVGLLGLEDLSAFFAVVFAPQLSKAVHDPVSPPASPMASPSDFVFPGAHAAPTERVAQIRKVRAQLDAKRAVAASMISNLSGKNALRHVSLDTSLADVLGLLSQPDVNCLVVSDSRRSDDGAVCGILTATDVVAFVVAEAERDSVLANALQNTLDALTTVVLQQPAAVISGDRSTVDALVRMQAEQLSVLAVMDPVGGLISPISSREISQEILRSASRKILTTPLSTVVKSLRSRHPQGTDGKDAHPAVSVSNSASVARVAAILLATEAGGVYVVDEPKVVMTPPLSCVSASPGKELPALSLDTDMMPLSRSVSFTPAPAQKHRRSSTQFWTAPRTSFSGGSSESSRPALPTFAVATGGETGRERRASNKPDLTLSSSLASLPKSGSAAMSAHIRTSSAARPLRPRSLSLAHFSLDETNSSRQFGMQAAYRSQGSWTPVTPTAGSGASSAGSPSSPFGNMLVSGFFGEAMQNGMPRHVVTMKSILQSLLAATGAANEEALET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI06</accession>
    <name>W3VI06_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI06"/>
    <dbReference type="HOGENOM" id="CLU_288539_0_0_1"/>
    <dbReference type="OrthoDB" id="2553457at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1070" mass="114566" checksum="5858BB241A0FB455" modified="2014-03-19" version="1">MAGDDTQNHLFSSASSTRRSSEKRSASSKPNSRSRTSSDTDISSIGGVHYPCFGKVDLASYIAARTYGLNFRRLHDEWVVLGRPAINTRHWPVLPGHRGLPASPDDFVAAAEHYEGKIFSQVALDMTGKPADRNRPLDDFIISMVVTAAIVNADFLVHRMVRDEILREEAMVQHVWHRYFTTFLHDAVRHFAHERTVCDRLGTHNCVVPLLYGQACAMTLPTLIQTFDYQVQIFQNLFPNFGDHVNRCAASQPSQRLDVDVIIKEYITKVEGSTRQAMAVGRSASTSGQAGSSGNTQSPYAGTIHPEEDPQAEAGPSRPRLAVTVVPDEVKGRPDLFVSDIDSAIRCDVPLEQVLKVIDSSMTVSAPSSAASTPPPLTAMTSIRAPYHSSSVSSRASFPSSDADWPLRRHADLSDSAVEEGDADIDSANLMLRPPLQGQAQWPVGISRRSTSEEHNAITPDEAMAATQTRTHSNSVYSYFSSLPATPTELLSPDGVVSSQEGAQSYMDRRPYRSNSGLLASTSAALESDTRKRTRAEQNREKMKAYHRRVMQQREALTTVLAEMSAHVGTIPMLSTRTNAAGLLGLFSGEASSSVGGDGASGSASASSVGRSAPESSWSLSLRNKQKQESKARLRKREIDQVYELSLYANYANATLSRPGAAGTSTSPGSRGGSGAPGTGDVQGGMSTAWRQLETAQMAEADAQMTHAILRVFLRHRPSWIALISAEQRLASEVAKLSPRTEDGAGAMDGGSAGDGSPGSGAGKGIKALIDRVQMEERAGTMSMLSLESAHMLSRGMMSGAGVNQPGPLLDASGRPRYASQGSYGASVLLDAGAVVLSPGREYGATASPSGVTRPMGGEEGADYFSQERRALGGRQGDSAAGTQRASGSGHGAMSGMLPAQSGFGYGFYAGEAQVRANAQSPMGGMAAMSPPPLPTQSRMSMSYDGRGGYGATTTTTSRMEQSPGLYHAQSMPMQPYPYAQAPSQPTQMPGGGQGLVQQGPQPMTDAMMAYRSNESAASSYATSHHHHHQHQHQHQQQQQQQHQAQQQHQSQTHTQQPPSYGQQGGYHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI12</accession>
    <name>W3VI12_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI12"/>
    <dbReference type="HOGENOM" id="CLU_018152_1_0_1"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="788" mass="87182" checksum="388E1D088E519D95" modified="2014-03-19" version="1">MASPHVPKGQGLRFQKQGNASFAKATAAKDAAAANTLLARRNALFQDYARMHQKPAWSPSISAAFRFLIIIRVSSAMYSVIKDCDESFGYWEPLHLLVFNPGNAHANVPFQTWEYSPQFAIRSWAFVAQYLPLAKPLAHFGVGKRQVFFAVRLLLAFVSSFVDARFYKAVADVFGARVGRYCLVMLAASAGMYEASVALLPSTFVMHATTLAFSACLYPARLPSTDASVLNTPSQRPFRSERLILATSSFAAGALLGWPFAIVLAIPFVLEQLFMRADDTVATGKYSHWIVARWSTAIGAAVLAVLLALPALAIDSLAYGKLSIVPFNTILYNLFSRTRGAGPELYGTEPPTFYLSNLVLNFNVFAPLALLSLPLLLVTARVDPKRFRRPAEDTSSKKGNVAVEQPSSLFSLALLRIAPFYVWLLLLSLQAHKEERFMYPAYTLLCLNAAVSLYLTRTLAELAFVQVTKSPYRASKSSLFTTITSTLLAAGILLGVLRSVGQLNHYHAPFDVLFHLEGYELPRLVADKFPDTLSPAIQQRIARGLPAVATSEEKEYNDRGYGAENKGVSVDLSIDLSPLATMQQPVRLCYGKEWHRFPTHFLVPAGVEVEWVRSEFRGILPKHFAHASPSPATDAVARVLDASLGWAWPWSSTTRRVQSGFNDMNKQELDRYVDVDSCDYLVDLDLPHRSLTGDESELEPRYAVQADWDRVFCAPFLDAEFSRPAADPRDAALKRAALKAAAAFHRAFWLPKAWPGSANVYGDYCLLRNRSSRFAPTTTTTTTTNEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI35</accession>
    <name>W3VI35_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="2">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05276</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI35"/>
    <dbReference type="HOGENOM" id="CLU_018822_0_1_1"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000021">
        <property type="entry name" value="Acetyl-CoA carboxylase carboxyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000160">
        <property type="entry name" value="Chromosome 19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF46">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="303"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="559" mass="60777" checksum="D360358EFEA9B799" modified="2014-03-19" version="1">MSLNALQTPETPLKPAHPALRLPVLELPPLVRDPEVEANRAANEALIHELTERTQSVLNQGSGKTQLLHLSRGMLLARDRIALLLDQDSPFLQLCTFAGYNQKDCTPSGSVVGGIGLVSNTLTMCIAHIPTLQGASANRAQIAKIQRLGQIAHENRLPIVFLVHSAGASLQQQFEFHYGARQFYDLATRSQDGIPTCSVVFGQCPAAGAYTPGMSDMTIMIREQAQLFLGGPPLVKMATGEETTAEQLGGAEKHATVSGVADCLVNNEVEAITEARYWVASLNWAERISRPEALHLPKWESLEPLYSMDSLLDVAQANIKKPWRIEQLIARITDGSRFNAFKPLYGANTVTGFAYVAGHPVGIIGNNGVLNPSDAQKTTQFIRLANNNNVPLLFLHNISGFMVGREFEAAGSIKYGSLLINAVANSRVPHISIIVGSSYGAGNCAMCGRAYDPRFLFTWPQGRTSVMGPDALAGVVDMVEREILNRSGRPVDEARQQKRRDAMHAKVSTESDSYYSSSRVLDDGIIDPRSTRDVVGFCLEIFAQEKIQGNPGFGGVSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI82</accession>
    <name>W3VI82_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI82"/>
    <dbReference type="HOGENOM" id="CLU_1082293_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="257" mass="29390" checksum="D4BF31BF1776118A" modified="2014-03-19" version="1">MYTSAPSAISLRGSLRILAPRKSAVAIDECRVRSDDCWTRRLAAPRPSTPPLLRRLRAGPPSYLVNVHQFPILLRSDGSVLKDVDRGALPKLGRLLPYLSETLGGVADVDVQRPEPGFDGFYVWQSYDMLCMQAKQGYKSKQHSSKVSPAKRKKHRLDYSKQARTKRTDEQKAADAARQGRNYHRRMANEPADIREARLKKQLKYAPAYQVSRRDDPEFKRRKSENGRRYSKKNGEELRARKRELAAARADDTNRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIN7</accession>
    <name>W3VIN7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIN7"/>
    <dbReference type="HOGENOM" id="CLU_272735_0_0_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="106"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="336"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="972" mass="106793" checksum="39A72B185DA69D88" modified="2014-03-19" version="1">MTAALARCMRGSAIRTACILPQSRTLSLVASRAWTKPASSVAAAAKGHHFPQLRLASSAAAARITGPSGEHLVNDDALAATAASSASSPEFSLRPYQEECIQECLAALESGVTRIGVSSPTGSGKTTIFTHLIDRLPPRPNGGDRVLIMVNSIELALQAANAVTSMFPDKTVEIEQGSKYKASGLADVTVATYQTLNRSQQRLDKFMPSCFKAVVVDEAHHAAAPSYLRVLSHFDAHIGLDAEARAATESDSVPVFGFSATFSRHDGLALGKVFDRIVFHKDFLEMIGEKWLCPIRFTSIKADIDLASVKLSNFNADFAASSLAAVVNTPVVNRLVLKAWLDRAHNQRRSTLIFAVNIEHVQELTHTFRQAGIDARYLHGGTPMLERRQLLEDFRAGVYPVLVNCAILTEGADVPAIDCVLLARPTRSRNLFSQMIGRGLRLSPATGKRDCLVLDIVGNIEKGVVCTPTLFGLDADDIIEDESPEGLLERAHEAEQFDPADVEGDADPFAVELADPTKITYIDYDDPHQLQQAMLARSSVVETMSANAWVDCGGQTYILDVPRYGFVTVERKANSDHGDGSAPAEGAEWTSWFTPSNSDADEAAASMGRDPSSGAGGRRWPGARGGSPYRRPRHALDAPTLEAAVRGSDVYVQKNVLRNAPQLFAMLNRRAKWRATKATDSQRRLVEKRLGLSKPSQEAEGDKDGRRTRAMRSASELTKGQASVILTRLLHGAKAKWQQRVKRSNKVWRANEREKQRRDRETPSDFAAMWYPSVTLVALVMLLLRGVFASGPEVDKATIGRKMLQDYRTHREALAARMRSTSFSPQTAAKKEILMKQYFSALSNALPEKQPELLQKINDLRQAGYRFGASVDPGLHVPFGTPWDPTRFGPYPAKRLAEGAYGKSKAAVEIEVENAREALDHQTMREVMHGRMEPVFADDFQLVRSAIDFHAQRLLQNVEEPVEDILKSVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIS3</accession>
    <name>W3VIS3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIS3"/>
    <dbReference type="HOGENOM" id="CLU_017205_0_0_1"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="76876" checksum="F5CF82A1975F0DD5" modified="2014-03-19" version="1">MPRSLVDTVYSGTEWFASIAAPPLRSTYDFLFPPLDLLDDTRDAAAVGRRAGSIPPPPPTYDDELDAWDSFSDSPWSFVTSRYTIALVAVAIVNNRIQHICRPRGGARTRLSQLQRVALRLPGLVLLARAVLIFATVVVDAFVAPTNPLYAALRRTTTVGWRDTWLAHKPVGGWAGERFGSSSRDALLRARDATAMWAAFTSTCVTVVSDALIRSLDADRDEPGAFNLVGFAFLLHFHSFTPDAPATEHVYLCILLQLLQLWTIALTRCRRPVYAPRLVVSGVFGVVSLVHYVAVESTTGQYPFLEVLSRAPELALVCIIALTVGLHALTMLLLEGRVQPHRLLFSRSNMPAWEEDWSLALFKLGTACMESTRLTGMEREAEPLVVWHAPYLELGRSGGIELVEPHARISAVDEVAGLAREVKEVRIETVRQSAWSFGHAGLARVQAAAQFGLATLRVVAAIVMAVAKRMARAAGVEWRVPAWALRAARGVRLVWHGTNGEARRQARQEQTQRQVQRIRPTVSPAEPVHEELDEEDTDFAASDAETESIHSATSDTVGADEISHLISEHTSSETVTESEAFNQLLLAHLTRSAAPLTRSRYTALLPRGHDDALSAALADRRAPPSGAMARDDARRLCVVCCTEERNVICWPCRCLALCMDCREHLASQPPARTRGQPHTHLCPTCRTPVQAFSRLYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ10</accession>
    <name>W3VJ10_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003327_1_0_1"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09880">
        <property type="entry name" value="PIN_Smg5-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="795"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1110"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1426" mass="158191" checksum="E1E51326B5B52C6B" modified="2014-03-19" version="1">MPFQRSSSAASTQLLFKPPSALGPSDFASSSAAIVPSKSALAESSFKPRDPSLGAQEAAPARKQHHVSFQEQPEHAEPQQKPNRRRERSHRSSQSSSRPDASESNTKGSEQGSAKQSASRASSRHSRNDPSEPESSKSAGAESALTTSTRSRRQGRRGNDKRSDRSQRAPSEAATATTDPTSVSRPNSRAATSTKSEASTSASRRDPRSREPSASGRSSRNHSNHAGILPDLRLQDASRSESVARSQHSASSRRDRFSTRSHDTRSVPGDAPTARDGRQLFDPRRDDPVKFASQQRLQTDERARAGSSVSSPRLASASSLQPQIPMRRDPSESSRASLLARSPIIKPSIADVAFTPAIDPADPRALQAHVLEIKKVYRSISAMETALQEAHHAEADKARLAMAEYVPPDVRDPSYWITMISRHRSLADLHSSFFEMTCRPELPRSVQELAETYNLPSRLWQNAFHLMLESLRSNLASQPPHQPASRKTELLDYLTEFIYFAYSFYSALHESERYKNFGRAWIESLGDLSRYRMAVASLAASMAIDGGGEEIRNKAHDGRSPVLALDARIDDAQDDSDGDADDDDDSLDEHRAEANGADARRRHARRRRSRRGHRDDLHNVDKASIGSAALGDWEWTEKETWRQTAKDWYALGITQAPNIGRLHHHLGVLSRGEDDLRALYHLSKSLIASKPFSSAKDSVVALFDQERQSRRIRRGSSVGELFLYLHGLLITRVQLDDFEPVFDRFMTDLTALVEEHGPAGLPQSVWTMMATVNIAGLFEHGSDDSMLADLLLQQSHKSGKRPNRTERSRANVPTAILVSTSATKTDDNLLSELPRDAEWDDPSDDEDEAGEQDGQLIALDAKARGDEAEAEAANDLPDTLERAARLCFSMQALTFDLTSADASLRSNPYNTTIGTFLLSLCQSKRAFRLFERFVPWDSWLQRLESSIGLAERGWPKMLASPYITAQLLLPEDYCLRGILGLSRHLYDRHLWRPTANEGGMSASHAFANEVEVLDAEDGELYTRIESAWRTAAARKGERDEASATLDTVRIYRMAFVARKLAKAGRGFELDGKTSKLSLSKMLQTRLVRRKMEEEQRELEARIQQLRLQAANREPASARFEEPAAAKYEEPARSDDEDDFDSDWEEDEPAAARERTHSLDAILPTPEGADASDEIQALHARSCYLRDVLSSVRSTLTRGGGGSHAAKERGTRVGRVKTDAAASACENIVPGYTVLVVDTNIIVTPGEVIAQLIESQRWTLIIPLAVITELDGLRRNDSELGRHAERAIRLLETRIRTHAKFVKVQTSRGNYLSDLSCRSEDIDFAWQGQGAGAAVREEDAADTKSVAARNVDEVILRILAWQRDNFVDRRNLLQPTAARKHDEPATRIDSAHKSVLLTLDRNLRLKAKSRGLPSVDSRAAAALLELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ53</accession>
    <name>W3VJ53_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ53"/>
    <dbReference type="HOGENOM" id="CLU_467015_0_0_1"/>
    <dbReference type="OrthoDB" id="2349883at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="673" mass="76018" checksum="432F48DCE393B7D5" modified="2014-03-19" version="1">MTALKLVQLGSAGRAPLLRHALSKAARMALVYSSSSPISAVPRSATSAHLRHATTKAASSASESSSKSPSATAAPISGVPRHHQAKVEVLPFRISSKSAREYLTTLAKTEVMPRVMTQWDIIKHQVRSLNPFRGFEADEQIVKLERMTALYLPTWIVDASFEAKCRGNDGKAEANFITVSSRFPGHSWKPMDSLPLFPPPPYDMKPNQTNSGDPSLDPSANREAWETLAMVDYESYESYLKTKGNSKVQIQGGLPEPLPFTISPLFLPDMIRDQLESADATFIAELAAGFELPGGDKHGLGLTMSLVDEDGKPIISPPVRFEPGSLKIDMMAAYPIMMPLHMAEFSYVEAEDGETRHLTFVMGGWDTSGLLFCMKEKGEDWKQPGQGAGPLLLHTLDLYPRPPIKTQLNEWYEREREQEKSTQRRDWWAESKLDPSDPFTRPNLTRKEVEAEIDRYRAQSNKHLQSDLQSRLKEKLKTELPIAAEIEKRSAELLERADWIHWERDEREAFQVRTARSDPAHTMITKAQKERYAAAVASARKAPTDPRPLRWLSQRDEREAELEHPDRKAGLGRYIFWSSPHVQRLSHNVYANRRYLREAIPEVLRSRKQMASLAEGGYNVDTSLVKVNLQDGRKLSGDEAYQTVAANDLSMRQQREALKPRWLKALQNSFIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJR6</accession>
    <name>W3VJR6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJR6"/>
    <dbReference type="HOGENOM" id="CLU_099163_0_0_1"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="189" mass="20608" checksum="350419235D9E5C3B" modified="2014-03-19" version="1">MSGAIGNMAFMFGAMQVAKRIPFDDKPEYITYARAGYVAVQLLCLAVYYYCSIRVKKANDLTVIKYVNAKNPMSQEPGELVTTTNRDYDLAEISKATRGILMGCAMVGFMHLYLGYTNPLVIQSILPLKNALESNMAKLWVWGQPATGDLKRPFKAPPGLFGAAGQAGPQTDKAAIKEAERAGSGKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJT7</accession>
    <name>W3VJT7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJT7"/>
    <dbReference type="HOGENOM" id="CLU_013872_0_0_1"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="748" mass="85454" checksum="1AA4C3D6DF203C93" modified="2014-03-19" version="1">MADAGAGPSTLPSGWTEHISPAGRAYYHHTTSGVSTYTRPTHSHQPKRKREKPTSKTPIPGTDGWFKVTTNRHNAFFWHETSKKSEWMAPGHIAAHVQQLEDSLRQEAEQQRKVAQQQEREGREKLKRERREKKRKAEQGVPITEFGAAEAKRARPDEEDDSEHSDLDDTDEDEVEAQDVEPVSDTESVAVEAGEQDDEEQDDEEWQRQIAEQMAAEAAASAQESNTDASPTPPPAPEATLSTEEQKTAFMALLTSLNGTPHEINPMAPWDLELPKFSHHASFLALAAREREEAFNEWCKLRLREKRAARSTQPPVKGDGGSRAEAEFRALLRAEVRSTRTRFADFREAFVRDRRFGAFGRGDGERERVFKAYLVELGEEKRRAAEQAETAFTALLGEKLPGNLRNKVAEAKAASGAEREAVMAVWMQAKHTPGLVEDKRYDAVGSSTRRFELFAQWARGERRPQAPSQAKESRGKERDGRDGRDGRDGKEEARVRAMREREEKVRRERQRIERTNRAALASTERSESRRQFSQLLVDAVHSPHVSWRSAAARLEADARFGALPEGDKESLFSEHVRRLAQTEREKLARVFERYAPALDTHRDDVLAQTMHDDALAHPPLSVYRHEPDKLDAAYEEWKRARQDKAKRAFDEMLRESAFVEFWGRMKKVSAETRRDQKQGAKKEEEEEEEEEEEVMLVDMARTVDLDQIQAVLGRDARFRAFRHVPEQREAWIRQHLHSLAAPSKSVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK67</accession>
    <name>W3VK67_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_03615</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK67"/>
    <dbReference type="HOGENOM" id="CLU_015433_3_0_1"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="12">
        <location>
            <begin position="109"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="11">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="287"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="368"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="721"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="810" mass="86678" checksum="9D5590BF0AE97E80" modified="2014-03-19" version="1">MRVEWGSASQPRSILSKARAENLEIEWGLGAPSRAIDGVTDASRPSKRLPPNKAEWRRRLHGPLRRGTTITASPSQHLKRSARAQHCSACHATCSSEARPRIMDRFKQIDASNSSIGALLFHDEEVVSLQDGIGLYDGKEKALHQSNGTVYLTSHRLLYVDDLEPHRHSCSLDLSYVKQSEYYAGFLKSSPKITLTLAKVESTDDGSSTDLILDANNAHRTSAPRRPSPLSSQADLQPANATAGRDWRVGATAADSSVAAVTGPNWVCAICGFSNAAERSSCELCGVTKEPARPTPTRTPVPEHARPSERLTPSSEGRDSPAHNVSNSPSASGATGKQDGLACSVCTFLNHPSMDKCEMCGSSLGNSWPERPSTSSLSTSRKSTDADASSLRASSAPSRASTPASISLSPPTDSVKLSFRKGGDKAFYSLLKSTLKGKAWAASSSTATSSASDARAVRVSAGMVDLDGRSAALKRVGIDGILSSVDSTSRAQNDDMHGALKDLEALMRKAKQMVEFAEALNAKLTKQEQAAAAAQAAGRPEGAAKPDQEAATLIRSSLVQLGLPTPAVTPDMARDQEEYHRELARELAGLLLGNPSGGQRQGLMGAGRIAAKGKGKESLPRVSEDELKGRGLLGLDEVWCVWNRARGVALIPPQALRSAAAFLPDITSPSVRIKTFKSGLSVLHTPRYSDDAFASRILHLLDALEWEHRMKRIEQAQALTISDRRSAAAPTTDAPDGTRPAQPQQEVSYGDNLSPWGAGASILEIAEKEDVPILLINEMMEMIEAQTGMVVRDDGGPNGTRWFVNHFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKF7</accession>
    <name>W3VKF7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKF7"/>
    <dbReference type="HOGENOM" id="CLU_039352_2_3_1"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="198"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="401" mass="43241" checksum="8F1DB92790AAA767" modified="2014-03-19" version="1">MPSKRKRSGPGFNRDAPADSGGYKRTRPAYNQVYRVPSRNISGPGIFVTCVQGKERKAALQFIDMLNELADRLYPGIAPQPVPEPSAASVGNADDEEDMDALRNGAAASSTETKAVESQAPETETPAKEDKADKAGDDDIEAQIAAELRDIKSSERRRGGGGKAVRFRSVETDTECLVFISVAPPFDPYLLTYTLLEEVESTGVARSRFVQRLTPVSTTCPANATALADLARSVLPGFFGTNEGEGKTFKIDPRIRSHSQLKRNDVIQTIAANIPTADPENDGGERRRIHNANLTEPDLWIVVEVVKNAAGISVVRDYNRFKKLNLQSLAQTTEGEAQGRVADNLVQDKAATKAAETKAADKEPQAAAQPAVPAAAETDTPAEEENSAASDPQDMSAFRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKL4</accession>
    <name>W3VKL4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKL4"/>
    <dbReference type="HOGENOM" id="CLU_524890_0_0_1"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="433" mass="45991" checksum="55FBA4F3743E8AFF" modified="2014-03-19" version="1">MLVPIFLQRWILLNAVRVCTIVACALVIASTIRTLRLNFSRYPSTPASGYYLGTDIPTSFLGVFWSTLHHVCLCVVLGTVVLAELSLPVPALHRLFKNTLPFLGPNWGTAFLGVLMMLLSADLLSRPGQGNFAAASAWVLAALGLVNVATGCVWRAKAKLLRSPMAWKADVAERMDKLAEAKAKAEKVFDSLPVPVTAKEKVTKAAQGHAKGLLGMLGMRKESPQPVQEKTPARDAHFTPAATAAPTIFTPPLPSAVVMSRSAVPPAPSIFSPSPAPAPARALAVAPAPAATPAAAPALHIHTRSRSSSCLSSSTASTSSVYTLDLPQPPAPTLKTVRFDMLTPPSRTPPAEKTLCIDATPPSAGIECDRSPSVLASLQAAMLEAHAKASSIPPKKSLYLGSSQWRQEYARTESPSQPPHDDPDSTHRPYTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKR4</accession>
    <name>W3VKR4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKR4"/>
    <dbReference type="HOGENOM" id="CLU_055683_0_0_1"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="372" mass="40338" checksum="08BD7878DE480699" modified="2014-03-19" version="1">MDGDQLFRGAQNEAIDVTMDASSPSAPQDDAQPPPAPSLPTSATSSLPPDSELVASLPVYLSKSLLGDSSLHVFQYPIYPRDRPLPVPYSAAARGLKVSSRWRPRANRVEVELPLDVRAEVYNSERGVDFGAGADVLAQKQARADAAHGGASSSGEASGSRTRVKKEKEEEAAANRGPKKLEKVKLESTQVPNATEYMVGVIRDQALHLSRLESIVQLRPSMDYLDALDEAREAERRRDRAALAGELDSDEEDEEELIEMEAPGEGSSRSKAKKDAKKPAAQTLSVALRTDPNAKKGGGIGMGSGSGTGSEARDLLMAAQREAEAERWLDLEWRDERSHEAQQIFNAQLFAGSQTPLTCKTKPREYLLHALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKS6</accession>
    <name>W3VKS6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKS6"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000028">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="252" mass="27111" checksum="B8F0F3A55507A04B" modified="2014-03-19" version="1">MSAGAGDRAYSFSLTTFSPSGKLVQIEHALAAVSQGATSLGIKASNAIVIATEKRAPSPLVDDSALERISIICPNIGMVYSGMGPDFRVLVSSARKAAQTYWKTFGEYPPTRVLVQEIATLMQQATQRGGVRPFGVSLLVAGFDSARGPSLYQVDPSGSYFMWKASAIGKNMQNAKTFLEKRYNDDISQEDAIHTALLTLKEGFEGQMTEKTIEIGVISATHTKALGNGDHGDPIPVFRKLSESEVKDYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKX6</accession>
    <name>W3VKX6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKX6"/>
    <dbReference type="HOGENOM" id="CLU_012292_0_0_1"/>
    <dbReference type="OrthoDB" id="3355217at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="803" mass="86011" checksum="9EA83682E5DE9024" modified="2014-03-19" version="1">MQNSYAQLISQLSNTQVGAGRESSPDQRYYEGGNRYYQSPEYHDSLTQRTDSSKDTPPTASLASGRSSSDANHDDLRTPPEPSYDAFEPSLESAHYHPSPAHQEHRAPLYAQPDLPYASSSSALPLASQTAPNAGAHAPQLGSPFQPSQRQPQQPTRSLQRQELQQVLSRYDISDDSALEMLSDDFEAQRRAAGKARMMPGQHAESNNATAVSSPAQSAVGHGRRGSSNVTVLDASKPFTRLGTQDIAFSAANLPERRLTADDCVDIIVSRHPTLCDAPLREFGEDGQPLPPTKKQETSDEERAARKQALGVKFCAKQRLSLIKAMILMESRSASWKRVGPFNAANTNTNTAMGVDPMDATGATSHGEQGVGRLPPMPSPWSIEIRHEQLDVAQIKGKSKKSVELASLRTNALCTKCEGSKLGACLTCKAEQADECFWCSGTGREKTRAQAWCRRCQGAGVLKCNTCHGSLKSDCRSCEGTGMGEYGFFVDVTVKRVEMPAVPLATLFPQLESASASFQPSYDEVRAAAKLALWDSITKLTEARHHAVATKGGKSKSKDMVPVMAACVWENSTSHVVSVDVPLTAKFKKGASPALRPEGLQRKIPTQRRFFTVPTDADLCSVELSEEEVKKIVHDSIGDHAISGRGPSPATPPDSRGSSGYALGSPYGSTTPSPPMSLSGSSSASLATPDEGAGMSGYSTPSRVPSPRSDLPPAKPAAKEFVHRPSPLSQLAATTPAASTFSVQTDAARLDSNYSNGSPRSSPEQSPEGRSGQKLRRPSAGQILSKKLSSNILNKLSAHRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKZ3</accession>
    <name>W3VKZ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phospholipid methyltransferase</fullName>
            <shortName evidence="17">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_04452</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="17"/>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKZ3"/>
    <dbReference type="HOGENOM" id="CLU_086119_0_0_1"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="17">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS61421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="239" mass="26360" checksum="361CC1A3DD629603" modified="2014-03-19" version="1">MAGLFYKSPASAYVVPGVVDLTQPSLWIAVGSICFNPLYWNIVAQNEYHRKTITKLLGGRRYLGCYLLAVSIFSLGIVRDHLYNLALKDQPTHSLLQQSWVKPAAAVLFASGNVFVLSSMYALGVTGTYLGDYFGILMDSMVTGFPFNVMANPMYWGSSMSFVAVALWFGKPAGLLLSVLVVIVYAIALRFEEPFTANIYRQAEKLKKAEAERQALLESDGPASGTRNRNRRTPSKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL54</accession>
    <name>W3VL54_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL54"/>
    <dbReference type="HOGENOM" id="CLU_019904_2_0_1"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="99"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="187"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="54410" checksum="F0FF28972E605147" modified="2014-03-19" version="1">MSAHYVGQIAPNYVHSTMQANSDDDSFTFTVGKLDAGMAILIGEKASLIEFPSLLLPHGVSSGSVVNIRVMRNEQQERRQKDDFDLLQEDILHTFGQQAPKVPALRLRNVTQTSVTLEWERLSLATATLLSLDIYRNGQRLAPIPNPLHNTSTKLSGLDVNADYTFHLVMKTTAGTFSSPLIKTRTHTINDTSGISVCFGHVHDAEMLEAAKKALASMKAKWSDRIQIDTTHYICTDPRNPGDVHAQPSAHGNGYTKAMQLSIPAVLPHWIFACHDQKKMVGISPFYLDQDPPNAATIRQSIDQVLGKHSASAAEPTAATSAAAAPAQSSNASDAGPPPPPLEKDAKPVGSSAAESAPATEPAPATEIEHETQQEAAAAGSQAEASGSALGLKLNEDEPAPSPPQPQPQPPTPIITTSAPSDDGEDDEAPHASELPAPPPPPQVIVTPTEPEEAAADAQPKAEPASHEDESGGLNADAHADDDDDGDMDDVSLGGNTNADDENEVDEADTRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL90</accession>
    <name>W3VL90_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03337</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL90"/>
    <dbReference type="HOGENOM" id="CLU_000404_1_0_1"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="890" mass="99303" checksum="1CA385393B62C72E" modified="2014-03-19" version="1">MIYVYKRDGRKEVVKFDKVTARISKLCYGLDQNYVDPIEITRKVIDGIYEGVTTVELDNLAAETAAYKTTTHPDYAVLAARIAISNLHKETSKNFSQVVQALYDYINPKNGRHSPMISDATYKVVMAHKDQLDSAIIYERDFHYNFFGFKTLERSYLLRINGKVAERPQHMLMRVAVGIHGEDIESAIETYNLMSQKYFTHASPTLFNAGTPHPQLSSCFLVTMKDDSIDGIYDTLKTCAMISKTAGGIGLNIHCIRGTGSYIAGTNGVSNGIVPMLRVFNNTARYVDQGGNKRPGAFAIYIEPWHSDVFEFLDLRKNHGKEEVRARELFYALWVPDLFMKRVEQNGDWSLMCPNECPGLADCYGDEFERLYERYEAEGRSKRTVKAQKLWYAILESQTETGNPFILYKDAANRKSNQKNLGTIKCSNLCTEIIEYSSPDEVAVCNLASIALPTFIDPVSKTYDFKRLHSVAKAICKNLNKIIDINYYPVEEARRSNMRHRPIGIGVQGLADAFMIMGYAFESPEARKLNVQIFETIYHAALERSCELAQQHGTYETYAGSPASQGELQYDMWGVTPSDLWDWAELKAKIAQHGLRNSLLLAPMPTASTSQILGFNECFEPYTSNIYSRRVLAGEFQVVNPWLLRELVEQGLWNDTMKNRIIAHGGSIQNVPGIPDRIKKLYKTVWEISQKAIIDMAADRGAFICQSQSLNIHLSAPTFGQLTSMHFYGWKKGLKTGTYYLRTKPASNAVQFTLSVAEVNEAKAAAKRTGGTVKKVEDAPVVAVEPVAVAKVAAPSVEELTSGVGKLGIDGTVTKDGPGIRSAEEAKAIQDARAVAEVEKQKTEQLESAANGDVDPGFAAALERQKLRQLEADQLLCSIQNRDACLMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL99</accession>
    <name>W3VL99_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL99"/>
    <dbReference type="HOGENOM" id="CLU_411099_0_0_1"/>
    <dbReference type="OrthoDB" id="3345971at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="72449" checksum="621261401BC213E8" modified="2014-03-19" version="1">MFSSIVHHPCEISLHLVSQDIFVHPPPPNTEIPGDDKTLRGLVEIKCPSERHIQGVRVVLQGVQTLAIPENASASASSIRWEEKVIMEKTVEIMNDGTPGAINVRPSRSKGKEKEKQPNCNVSEGLHLEKGIHGFEFAFIIPASTAPFERSKHGRVRYILTATALGAGRARNNISTWKEIFIILHVNSDGGPAPLDIQYHDVHEALGPLSVSLTSASLTVGGTANLNLYHPDPPAGLNVHVVRVFLEQTFELYSELRKGWLKLPTEKLRLWEKGYMPYKTKQHTDAVGPEDSIWIGDMEHGAAGRPGRGAGNGPANLSPFGLPLNGSASAPVTPMEPATPMHLENGYRIKSVVRLPDDNILRPSTVRGSRAEIRVSHEMGAEVFFSRKDVLDTREDSDSFGKPKVQVFSMRRATTIPSCCCTFDTIHLPPYSLESPSNSRPSSPTPPSSLRNSHPELEHWKRTTTLNNLLPGSRGSSAFNSAANSRAGSRAGSRDTSPTRHGFASHFGSSGRKSRNSSPTRNNRGRSGNGLSSIGLHALTPASAGHIDQNGSHRNHGYSTPRSLPDNVPWAVSYLPDRTGTSHDTCNCGRTTEELTEAEQRLLEGVPTAPGAWVENTDANVPPPPWAPPSRASSPVSGWHYGPGSAREGFRPRGKLAELETPYGSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLS5</accession>
    <name>W3VLS5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="17" type="ORF">PaG_04227</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLS5"/>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="16">
        <location>
            <begin position="87"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="682"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="805"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS61722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116151" checksum="F5D082231BAEE4CE" modified="2014-03-19" version="1">MHKASTPSLLVTRLVRSSPSCTSTASPSLFLWQRCYHSRVPASQTRPSPKPALIPIPIFRAAQPPPPLHRVHPFSTMSDTTSRFGDWPATKVRDTFTAYFKERQHTFVPSSSTIPYDDPTLLFANAGMNQYKPIFLGIADPNSAFGSMKRAVNSQKCIRAGGKHNDLDDVGKDTYHHTFFEMLGNWSFGDYFKPEAIAMAWELLTKVYGLPKDRLYVTYFEGDAKQGLEPDTEARDLWLKVGVDADHILTGDAKDNFWEMGATGPCGPCSEIHYDRIGGRNAAHLVNMDDPNVIEIWNNVFMQFNREDDGSLRPLPAKHIDTGMGFERLVSILQDKPSNYDTDVFTPIFAKIQQLTGARAYTGKLGAQDTDGIDTAYRVVADHVRTLTFAISDGGVPDRDGRGYVLRRILRRGTRYVRKYFQVPIGSFFSQLVPTLVDQMGHFFPEITKKIDDVKAILDEEEASFARTLDRGEKLFEEYAAKAKAAGSKQLSGADVWKLYDTFGFPVDLTLIMAEEHGLGVNEKEFEAAQAESKELSKAGGKKSEAEAVKFDVHDLGHLEKDDSVPKTQDDFKYSLNSVDATVKAIYQDHAFFPETAKVADRAKNFGILLDHTCLYAESGGQQADTGSITIDGKSQFVVEDAQVFSGYVLHIGHLVRGELALGDKVTVSYDQSRRAPLQSNHTATHILNFGLREVLGDHIDQKGSLVAPAKLRFDFSHKQGVNVQELKKIEHISVDWIKRNVGVFSKEMELDTAQKIPGLRAVFGEAYPNPVRVVTLEHDLDTIASDLENPRWRSTSVEFCGGTHVAKTGEIGDFVITEESGIAKGIRRIIAVTGDEAASVSRVADEAEARLGEIDAIGEAAAKDAALKAFGTHLAQLDMSVVRKAALNERFSAIRKKLDAGLKAKDKADTKAVVDAVEAHFKEHTNATSFIHKFDVGSNMKALQTAMNTLKKMDKTAYLFSQELDVNGAKVAGGNALQAKVVHAAYVSKHDQSKGLNAKEWIETSAQHVGGKGGGKQDSAQGVGEMGGQALDDAIEAAKRFYTLKCEESSMPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM88</accession>
    <name>W3VM88_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferrochelatase, mitochondrial</fullName>
            <ecNumber evidence="15">4.98.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Heme synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protoheme ferro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_04022</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="15"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM88"/>
    <dbReference type="HOGENOM" id="CLU_018884_3_0_1"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="20">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS61912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="604" mass="67349" checksum="25898AAAA71D6831" modified="2014-03-19" version="1">MSAQNDSRYDPYIPSGNASSDPSGGGANFSNSKTARIHSEIDNTISIMRDNINKVNERGENLNSLQDKTDNLAVSAQGFRRGANRVRKQMWWKDMKMRIIIGIGIVILLCVIITDYAIWQLRASLEALEAEIPTHRFRSRRPIVPSSSQSTLGIPPRRIDPRSTFAQHHPRFTRGSMLSSASRTGMLATAGRAGLVDASTSFKLARPASLHRSLASHATKAAKPPTGILLMNMGGPSTSTTEEVGDFLSRLFHDRELIQLPFQSRLAPLIARRRTPKIVDQYNKIGGGSPILRWTRTQGKAMTELLDQLHPETAPHKVYVAFRYARPLTEEALDEMAEDGVTRAVGFTQYPQYSCSTTGSNLNELYREIQRRKERGAPEGDISWSLIDRWPTHPLLVEAFTNRIQAVLDTYPEDKRHKVPIMFSAHSLPMQIVSGRGDPYPAEVAATVAAVMTRLKWSNPYRVTWQSQVGPAAWLGPQTSDTIKGWAKQGHKDAIVVPIAFTSDHIETLYEIDIELQEEAEEHGITLKRAESLNDEPTFIRAMAEICASHLSNVEGTPNRNNDRRGEDVWTQGYTSKQMLLRCPGCVNAVCGEQKAFFGRTPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VME6</accession>
    <name>W3VME6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nicotinamide mononucleotide permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VME6"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="504" mass="55233" checksum="A3033286018D182C" modified="2014-03-19" version="1">MVSAAEKNKTVAHDTFDAAMRPPSLAIDDAHPTLTIAEAEEEEKQLLRKIDRRLVPCVWLMYLFSYLDRSNIGNAYTGGMGTDLKMDSNHYSIVLLVFFATYVTFEVPSNMLLTRVRPSIYLPTLMFLWGGLSMCFAAAKNWQTIAALRVVLGALEAGFAPGVLFLLSSWYKRGELARRYSLYYSAVAISGMFGGLIAGGLLQKLDGAHGIAAWKWLFIIEGAATCGVAVAAVFVLPDFPATTRWLSPRERAIASRRLALDSVGSAQGGDEDITHTQAAKMAFFDWRTWCFVFLYMLTTGSQTIQYFVPELVKSMGYKGFHVQYMTAPIYAVALAAILGFCFSSDLRKERAFHLATASAIAVVSFACLIGVLDHKGRYVLLCFGVAGVYAACPLVSIWVSNAIPHPSEKRAVVQAFVNGMGNSASLYGSYLFNKGDKNYNRKGFGVTMAFMLLAVVMSLVIRHLLAKYPYPEMQSVGDADSANSPDSGNGSRLNVDHDDIKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMJ7</accession>
    <name>W3VMJ7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMJ7"/>
    <dbReference type="HOGENOM" id="CLU_348560_0_0_1"/>
    <dbReference type="OrthoDB" id="21648at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021900">
        <property type="entry name" value="DUF3512"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12024">
        <property type="entry name" value="DUF3512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="827" mass="88504" checksum="6A2D135A5B5369C6" modified="2014-03-19" version="1">MTSPLRRSTRGTRNADATATSPEPSAMSPSASPTKLDRKRKRVDESDEQPPELHTPDQHASAAASNSAVNGHSDASAPADKANGVADDTATQDASQKKQLPPTLQALLGISSSRPTQALERAKTADESSSSKVDELLLLEEDATKLLAIADTLNVADLPATAPQPDVKGKSRSAKASSTASHAIRAILQPGTPLRDVRARLLSAREPLLSKPQVAQHLRTSQTATPPESLSTDLAHLSSLTLILGLVDQLACRMRDSHPQTDAIKAELLCADVETRARLLESRMAQTAKEGKATASQSARVHVRPSEDRSSDVEATNRYALHMRLPRGDYFTKAIPLDRDQLKKLDPAQADIVQISAQSEEQMRTLKRQGHVPTPTLGQRLGRSGHRHRSDSKRSMQPKLQPVTFLNYGNYASFAPSYDSSASSISYATSAALWRTSAKAHRSLSLTWGARPFQEEDLLAADDDDDDEEDADTSSAAIAAPAPLSDAAHVDAEGDVAMADSPEDDVAAALRELLDGVDQGGVNESLHKLSEDELITSHLRFNMMLLHRLQEFQWARLRRSYGPGASSRKAILATEEESPSADEEATAALLLESLSAMVALQPRAVNLASEAVESLVPHASKLRAFSASSGAIDPDLLGDVRDGFWGALDANVVKSTRTSVVASETPLLLRDDVTVRLADGSGSKAKKTSRRMGPGGTQVEERGRGTLERFASSRTYDQSNDRHDAEPARTTGPPHSTLARSPSKGDETPSASRTPSQGPSHASPMPAHPHMHAAYGPGQAQGMTPQSQRLMPGPNASYAFASPSGGPNHLGRPMQYQQPAYAQSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMK1</accession>
    <name>W3VMK1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMK1"/>
    <dbReference type="HOGENOM" id="CLU_040729_10_1_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833359" evidence="7">
        <location>
            <begin position="23"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="235" mass="24944" checksum="A722A344BDFBFFFC" modified="2014-03-19" version="1">MSSGIGSLFSSLFVYLRSLLFAKHLEICVVGLQAAGKTSLVNLLSSGQFADEMVPTVGFNMRKVRSGNTTIKVWDIGGQPRFRSMWERYCRGVSAIVFVVDSSVPLPSSTSKQTAASASTSPPAHSDAPPSAAASAQKVDAATGASTASPSAWTVATEELHALIERPHLAGVPLLVLATKNDIKGAARVDDVIRVMKLDTIANREVSCYSISSKNQVNIDVTLKWLVARSPAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMP0</accession>
    <name>W3VMP0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMP0"/>
    <dbReference type="HOGENOM" id="CLU_576454_0_0_1"/>
    <dbReference type="OrthoDB" id="3365359at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="471" mass="47599" checksum="45CAF577B56A0E02" modified="2014-03-19" version="1">MSAPTPQPIQDSAMATDESMRDDSSARKYNKTSHLQKRSQQEAYAVDPAASASAAQIAASVEAGQPYDPVAEYRRGRALTADNLERIPNADQLAPGIRLPGRVIDPHGADTDMQTSSDADEGAQSLETGHTSVGAFGEGGAPVPGVPPELDPRTPSFRPHSPGEASVFSVAVQPPASPKASILEASEPASPFVESTPSRSATDRYGVPVSSASATAGSSSYSVSARGSSPPLSAGYSASEAFNSAMRLGPGPSMLGRNVASVAPSEAGSVSSTGTGGGPGSAGTADDQEVALRAAYIERQRMRERELMGGEAGVGGTTIPTFALPARGTTPLAFAPGLSARLGGGATGSPAFDNVSRAGSTAATTGTSTPPLSPTGSEIPYAVASPSRRGSVDSTETLGSMRAPPSVQGFELGSGIESRRMSRGGSSAGFADAAYDTGRRGSEGAFISNAMDEDVQESAPAPSLHTEPEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMP9</accession>
    <name>W3VMP9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMP9"/>
    <dbReference type="HOGENOM" id="CLU_1251138_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="221" mass="23679" checksum="219F061307E7C2A9" modified="2014-03-19" version="1">MRSPHGLLKVFREVALPASRMHCWLTWSEPASKRQDQLGLAAGAPTAAGSMTDLGGYPRSRPACNNAFCQSAWPRLRRNVCRSAGRALRNPIEERKVSARRLLASAGHRSRNPRRASLAWPCRDALARGHLASLHGAAEFPCLAGASRENLRPTLSFFQLGLPALGVASNSTATASLARCSTISSLSPPLILQQQSLHSAPGTKPSSPLPLLLPLRIVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMT2</accession>
    <name>W3VMT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMT2"/>
    <dbReference type="HOGENOM" id="CLU_845022_0_0_1"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="142"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="329" mass="36423" checksum="71A137C08CA5F917" modified="2014-03-19" version="1">MALWHRKALPSSASPHPRLQRRERVQSGLLGEYRSPARSPVPPAHAKPKQASAEIARDPDQGLLANAPPVTSSSPSTTSFLSVASVRPFTAHVKAFIRHHRLISAPSTRSHTAIASERRPAALHPLAPQARQRPPRISPASIAAKALIGQDDLAKTSLMSDYEITLINDSMQEFYVRFHGPDETPFAGGVWKIHVELPDQYPYKSPSIGFMNKIFHPNIDELSGSVCLDVINQTWSPMFDCINIFEVFLPQLLRYPNPTDPLNGEAAALLMREPKTYEARVKDYVQRFATKEAANAAGEEEDDDDDDDDEMSDVGSFSDQGEPMGDMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMZ0</accession>
    <name>W3VMZ0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMZ0"/>
    <dbReference type="HOGENOM" id="CLU_055672_0_0_1"/>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="292" mass="32228" checksum="1D8F9A2754F18DEF" modified="2014-03-19" version="1">MLPLHHRHHYHPARAVTMMVSTTYSSTRAATAPTQLILRGTREGDLAATLSAQRTPSSSRCAKAGRLPLFTWSDLVAIVSTGNLQRLARHPEDLREYFAWMDSVKLSYGSVQSFILAERLTASYLLDPPPAESDTAACFKGSFEPSRECQILVNDWPYSVPTDVIHNVVWSYRPILHRSLVAGTEKAVEEAAWAVVAKRGLCGSLSKHGLVVPSLQDHAQHVPDLHGLVGTCGEQEAEAKVHGALRNACREIVAFVEKHWDLDMCEVVFFANPPSLQSVPSLAHFHVLVRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN94</accession>
    <name>W3VN94_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN94"/>
    <dbReference type="HOGENOM" id="CLU_016511_0_0_1"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="2">
        <location>
            <begin position="119"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="814" mass="90817" checksum="9892152BEDCFF635" modified="2014-03-19" version="1">MPSALYLIPRGGSSLSLPSRTLAEDELDLDLDLDLQAPSSSMRQHLDAEALPQPDFFENLDELHLWYQMRHAEVLHDHLEPSKNHSGPPTHPASTATAQPKPRPKLVVCHDFQGGYIEDPRQQGYSLEHLHLVDTFIYFSHKRVSIPPVGWLHACRRTGTKVLGTLIFEWAESAPDLARLLRGPERKAMPLHGQVSFSQQYAVELIELALQRGFSGYLVNIEVALDLGFSCSGEPWPAWVGQQARGGEMYQNAERLRAWVHFLREEGTRRFTQAGKRADEWEVMWYDSVVYPHGQLAWQDALNEYNIDFFLSAHTFFTNYTWARPPQPLPPGELVDANDESPQTLQLRGHTLTGPEAGGYHPQLLLSAAMADSVERARTHVYVGIDVFGRNCWGGTKAWRSLDMIGPHRSEEGALQLSVALFAPGWTWEDQDAGQTLPPAQQSIQRKWSDWWHIDLAFWIGMPRPLTPTTHRITLAEHDVKPVQLYFGGANLEKARLERRASTHGFYTDFGFGSGTRWFDRSEVVHEWPAGFTDMGVCMPKPDLLFARWHQYKQEASRLGPQDLTWAFDQERAWTGTTSLVVAMTPADDTVRATTEVPLCSAVVECRANQWTEWRCTIVVDSQSSAADQVSPVVSTLGWGSAEVIQRNVERTKLEHGWHAVSILVRIRADDAAPVALSLGLSLQAGTSMVRVGAVQLSRDASEQPAGELQVHPAMGDFESAGDETARLQPATLVWATGQGNESQLCNVWIQAVGQPDARCWLGTSTREASTSEFCIAQPLALPPHLTNTLLEFIVTTPGVDYTVIARGPAHLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNC0</accession>
    <name>W3VNC0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNC0"/>
    <dbReference type="HOGENOM" id="CLU_008227_1_0_1"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="743" mass="81884" checksum="F885CA795E481A70" modified="2014-03-19" version="1">MTYSSDVYGRLGTELEIYDSLLSATSTPAEKAEDADVKIASSDAESKGAPKEDHKKPIQEILSSIRPSDASSTLPSRKTLISLLDKLDSFAEEQNVSGVPHVEELKVAALSRLVVATYAAALDTLLQDASKLEDETWYWTDIEESMRKTISYLIQTLPVRFFNVTKEVLELAAGTATHTIKSTIDSTGSEARGSDLSHKAKSLDKGTVRAALRSVLDTPNLVTSMLFPYTFRLEKSITLESVREDHESQQRKVATLRTQLSANSVTGGRLEAGAQKTKKQRVKALRSTMLTLTPTYLARHEAKCKRRGLVNERNLLAAKLGRLALQHEALADQAQQLSASSSEGAPADQVVLGHLNAKLKVLVDTFSNSDATDSKDVKIDMNASLTPEATLSTLRLLLKEGFDKQQERVQMVLSPEVFGQPSALVQRWPKLVLYPVGLVLLARYLSNNWNGIEAKLKETQETVRSFLIGWVWEPCVGLLDTIRHGNEGSVIVSRESLASDLQSLERMVTDFTKDKYGTSGAELQAIASRVREGDLTQVLKVYEAEMKSPVKSMVSGSLIRSLLIQVQKAKVDIEVAMTGIDKLLKSQQLLFGAVGIAPALGILYVGQSYLRNKVFNLSVQRSESSGRGYQMRAWEAMRRVDRLLSSPSRDASGDRRAAGGQEADRKDEGRDDLTQGLLLLDLSTLRSASGPLLMSLSRGKKAAARRLQRQFLQDIRDLESGEHRAVERMWRSWGSSVLRLPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNS8</accession>
    <name>W3VNS8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNS8"/>
    <dbReference type="HOGENOM" id="CLU_029389_0_2_1"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="113"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="406" mass="43128" checksum="017C76DD67B3F741" modified="2014-03-19" version="1">MAYPGQGGHHYQQSHGGGGGGYGPPGGGYGPPGGGYGYGAPQGPPPMGYPSGGGYAPPMQPPQGGVQGQMGYGYAPPSGPVGPSEYATNHVNYRPQGGMMGNVRYEYSSMQGKRKALLIGINYFGQNGELRGCINDVNNVKQFLRQRGYKDDDMVVLTDDQRDARSIPTRQNMTAAMHWLVRGAQPGDALFFHYSGHGGQAKATQGDEADGYNETIIPVDYQQTGQMEDDELHAIMVRPLPVGCRLTAIFDSCHSGTALDLPYVYTTSGNIKETNVMAGVGKGLMGAAMNYARGDVMGMAKGLLSTFTTAKNTNGADEMTKQTRSSGADVVMLSGCKDSQTSADATEAGKATGACSFAFLTVMNQYPQLTYKQMLNAVRDVLASKYSQKPQLSSSHPIDMDLLFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNS9</accession>
    <name>W3VNS9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNS9"/>
    <dbReference type="HOGENOM" id="CLU_013985_13_1_1"/>
    <dbReference type="OrthoDB" id="2821191at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25525" checksum="02056094393CC547" modified="2014-03-19" version="1">MIELVHDGAGRLRTAQPETGASQTLSELGVANAEESDVDFVIHAFDSALPYLASIGSEAQWGTTPFSEKPKVKSLFSAYAQRSYDIYSAESSSVTDEKDWKHLVLYEVRTPDGLWTRVAALGVSCDFPDYVPESLAGEGAKAAGNYAYLNYLISDRRAGDLAKGAAANLIPLAERQARALGKAIFYGDCWRGNNDGLIKYYERLGFQPVGPFEVPDKHGPNLEWTGYLFSKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNZ3</accession>
    <name>W3VNZ3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNZ3"/>
    <dbReference type="HOGENOM" id="CLU_114220_0_0_1"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="209" mass="23056" checksum="EC2EF2FFAD33E06C" modified="2014-03-19" version="1">MAQRPPSPGDEATPFLLRVFVKPAPFRPLDDFHSSNRVDRDEFKLHVWKTNTLREVAQMLYDADPSVSSPLALHAFRRISWNDRSRTYEATSIGVGVTRVPFTSISSLLSDITDKVPGNGTTATSEEPAESTSHADPTSPAALLGWHSLSDQIDDTAAAITLAQLDLADGDLIDCVVRPDPSLALAPKQSRSTDRNRRASTDRHRPYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPK3</accession>
    <name>W3VPK3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEK-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPK3"/>
    <dbReference type="HOGENOM" id="CLU_776404_0_0_1"/>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="2">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="357" mass="38276" checksum="A1677DFC03F30C91" modified="2014-03-19" version="1">MSLPSDAEITEQVRVIIEEAFDNGAVAEYSKRTIRNMLNEHFGVDLESKKKFISAATQDQVNRITAEREKAASTSHSPSPAKASKASVRASSTKARPSSASSPSKPAPKRKHPVSEDSDGEEAEPSASREAGQDADLSDTQVELTDFSELEDDASTSRKKSKPTKSKASSATAKAPKGKAKASSSGGTEAEQRLARLKKLVIECGVRRQWKKLYEAADVSETDFAGQCTVVQGVLRELGMTGKGSVEQARKIREEREFADELAALQENTVMSSDRSRPTRASRTKSTVVAISDDEASNASDGSDFETAAPAPRSSKKTAARETEDDAEDSDDEGPSRSRSFKSSLASFAADLNSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPK5</accession>
    <name>W3VPK5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPK5"/>
    <dbReference type="HOGENOM" id="CLU_368098_0_0_1"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13255">
        <property type="entry name" value="PH_TAAP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="74"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="438"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="725" mass="76017" checksum="22BA645B0E377841" modified="2014-03-19" version="1">MPSVSNAAAAASSPSTYGDSFDATSSTRLHAPSRLQDDHHSADDLEGDADADEDDDDVEHIGGSEAHHNMINELTVKSGYLEKKGEKRKTWKKRWFVLRSSKLAYYKNDKEYQLLRFIDVGDIKTVASVELKKSVNTFGIVTPKRTFYVRASSRADMESWIERLNEVMTQYAQSSTMTQEMAALELANTETPAPSATLPPQQRRSASQERAHPPSSAQPIKIGIPSRASYAAPAQPRPIPGSAAFSPFTTTSDSETGAERYGLSYASSTGPSMSGSPSTRPDPSHLFLAAGQSPGGGGGHTSGSEMSDAGGGHQRRPSAGFGSLPRQRSTSATRRLASFSSGAADQPSSPIFPPSSGGGGGQQVLSSSDEEDEWDEEEVADQAMPLPALGSSQNNAQTSSLATPTAHAQHLASPGQASGLSISPLPTTANDLIRDPNKVITQGYLMKQSGRRKVWRKRWFVLTPARLLYSRSHMDAKAHRQIAISSMLDAIEYEPKKASALPTSPALGGSANPFAPENGAAASERDGNSAFSPGAASSAGAPPEKPERRGSMVAVAAGVASNMSAGMVGGSRKRKENCFQIITPKRTFILCAPGEDEEIKWISALKTLINRQRNGPTPNGNPPLSPTTGAPASSFPFYATSPSSASAAGTPAQDKPGVPAKQTVPTDAPGGHAQLSSIGAAAQTLSSSSLASNTAGTQNASQDSPANRQHASQQPPANLPTTAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPX9</accession>
    <name>W3VPX9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPX9"/>
    <dbReference type="HOGENOM" id="CLU_076656_0_0_1"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="269" mass="30724" checksum="CF59A526C41FBB31" modified="2014-03-19" version="1">MVLYFTSTAVEPPATIYVGKDKFENEELLRYGLERDVWFHVDKLSSAHVYLRLPPNIESWETIPEALVNDCSQLVKANSIEGNKKANITIIYTPWSNIKKTGDMAVGAVTFFNDRKVKRFHIKEKDNAIVNRLNKTKKEVQVDHEAERQERLRDEGRVKKAKAIEDVSFGSHPSFSVLRSAARAASLITMLTLLNAPLLKLQKKAQQAEQKRRKEEAEARDYSKLYSAEAMEEERRRKEERRLAKLDGNASGSGDDDQDDGMDSDDSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ24</accession>
    <name>W3VQ24_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ24"/>
    <dbReference type="HOGENOM" id="CLU_510096_0_0_1"/>
    <dbReference type="OrthoDB" id="2556119at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="534" mass="59229" checksum="A94E3BD43588357D" modified="2014-03-19" version="1">MVATERDANEEGEGPKQTLHIPLDPERRWTNHVYASLSPVHWISDAGVPGSAVKDRTDTRAIFPGASPPCGTRTYPDPNIEAAMENNRKVRESAAAARPREARGAGNVEGWKVADTATTAAEEDQSRERQPEQERGRVYKDLLDFLNRDEAYADGAYSRRQDQRSSAQRYHPCGHFLKRESDQDRSVPTQSHAQGQPPHDNGFGTRARRRGEAKATDQDRASRQPSRSQMPPSVKVERRSASPLFHGASRPHGATPANVPRVHVSFRPTGLPTNGTEGIVMDHGRNGAVDPVAMQSPGNVIERIAASDPSGGPALIHGVDYLLNDAYEIWPMREYPEPGRPDTLGRCTRRFRYEGPAAHPDSNDYLNMVKAAKQQLATQFPCVPAEDWVIRGADLSPFKLACSSAPYPEYQVLLRVDSLDIRNGRGDVLNSMREALRAQGKIIAFWPVYYKDMIINGIPTQSDFTGTVYVLLRWTGPLGLSERVDTSRLPAFLDFADLPFPKRLPLVFTGRPADCEQCSAKEPLHLAKDCSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ50</accession>
    <name>W3VQ50_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF985 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ50"/>
    <dbReference type="HOGENOM" id="CLU_097615_0_0_1"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="1">
        <location>
            <begin position="12"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DUF985" evidence="1">
        <location>
            <begin position="90"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="232" mass="25986" checksum="CAAF05176B0E4A6E" modified="2014-03-19" version="1">MDRLYHYPQTNEELIQHYKLEPHPESGYYAVTWVPVQMIRSPFANNEERSIGTCIYYLLCHKTAGCPEKPAIALTASTDGSEIDPFKSWSSDVGVLHLNKSSTMHLHHAGRTKYTLISAKAPLGEGLVDENGDPLTKTVIMGDDIANGEVRQLLVEGGWWKVSEIPEADRAAARDGTTDPTRVGALISEVVTPGFHWDEHTYLNHAKLRELVADSPRAEELFAKYRPYVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQH0</accession>
    <name>W3VQH0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02805</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQH0"/>
    <dbReference type="HOGENOM" id="CLU_009422_1_1_1"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000220">
        <property type="entry name" value="CAMK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="219"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="350" mass="37361" checksum="46A604C52CD2DF3B" modified="2014-03-19" version="1">MGKSTKDKRDIYYRQGKSEGYRARSAYKLLHLNEQYGFLGGADEYALDAADPTTSTSDSAPRATGSASSARRFPTPTRVVDLCAAPGSWSQVLSRRLASVPDSHLVAVDLQAMAPLPGVTQIIGDITTPATADAVSRALSDGPDATGTDVKGKGKARAQLIVCDGAPDVTGLHDLDEYLQSQLLLAATQITFRILEEGGTFVAKIFTQHPQAGLGASLGNMDLKGARPATSGALLAQQLRTFFDQVDIAKPRSSRLGSVEHFLVCLGFRPPKNLPKGIVGSLADSAPNREALSSSESSDDGDRDDLVQYAHKLRSQLQRPDLPRHLQQSHTRLAATLPFVAHGDLSGFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQR2</accession>
    <name>W3VQR2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQR2"/>
    <dbReference type="HOGENOM" id="CLU_1190318_0_0_1"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="24341" checksum="6A430D0EEFD0F292" modified="2014-03-19" version="1">MWSQEGDGEDVLDVAGGCVRGHSWKSETRKWSNTTLNGSSSRGADGQAVAALSCDRGALHFENGASDQSGKALRVVWRFDRSGGSRPAAGRSAPSAPSGSRGAHTMAAPQQHHQAPPQAYSQQPPAMQQQRSPGLFGQMASTAAGVAVGSTVGHGLSNMLFGGSSSAPAEQAQQPAPQAYDQGAYASQQQNIGASCESQSKDFIKCLESTNDMNSCSYYLEQLKACQAAARPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQR8</accession>
    <name>W3VQR8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQR8"/>
    <dbReference type="HOGENOM" id="CLU_1816613_0_0_1"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="147" mass="16324" checksum="4F01BBD3703E8D3F" modified="2014-03-19" version="1">MSDLGPLGPDHNPFADDHEQSDTQTASPKPQATNQSNHVARSEANDATSEELAGLQQQQWQEQDTHLDVLSASLNRQHELSLQMNEELDLHHELLDEFDRDVDRTGLRLGGAASQLDRLRSSLKDHGSMWILAALIVGLIVLIALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQW1</accession>
    <name>W3VQW1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQW1"/>
    <dbReference type="HOGENOM" id="CLU_039532_2_0_1"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="133"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="219" mass="23054" checksum="A2A41932C13FF958" modified="2014-03-19" version="1">MATASTSSAGTSDAATPRFDFYQTDTAVTVSVFIKAALADQTSVDIAPRSLSVTSTTSTGSKFALHLDPLFSSVDPATSSYKLLSTKIEVVLHKAQPGVRWNQLHAASGNSAPTPQVTSTPAAPQAPQVAHTGKSAAPRARSKWDSFDPDADDGDAAPAEADINAFFQKLYADADDNTRKAMIKSYQESGGTTLSTDWSKVAADHVAPHPPDGMEAKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR91</accession>
    <name>W3VR91_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02336</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR91"/>
    <dbReference type="HOGENOM" id="CLU_023938_0_0_1"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="391"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="568" mass="59214" checksum="1CAB887E7063E543" modified="2014-03-19" version="1">MLPLALSFILYHIDHHNLTLNGSAELRLIVDPPASMADDTKGAGEGSSSPSPAATQAGDRSQILAQANRFLTSANVSESASDEDKREFLRSKGLTEDEISRAFRDAKSPVDGLAAHQSGLQPSNTGDLDAFEIAARQFDDPINADAIAPPPKSYPNSPLALYYDSPAAQAHNFAHSDPHKQGGNAASPLTRYQVLLQFFRTLSYMMMLGGGLTAIVVWAYRAYILPKITAMFDARSIVLKHHIMLFDKLRSNVASLATYVPVQRARIGGDDASSNGASSPLKGVLKKVHFHDDVDTSAKEGEKEGVKLTQHAKDAKAGSEKVVMPGTDVVVDAKTPLLAEGANEADDDADASASEEGEAEPAKLEPIDMMASIRESMASLAAALRGDLAGNPSAASTGAAPSLSSSPSRGARVASVADAGSGSDEWEDEDTEADGSDDDDGLEFDPYGAYQKKHKHTQTSATASSGSGSASLAGLKSTLASLNADISTHAFAASSSSSYSGGAFRLGPGSSGAESPKSGDLGQVKAEIRSLKGLLLSRRNFPSYGARPPPLPAAAASPMDARTSSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRA0</accession>
    <name>W3VRA0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRA0"/>
    <dbReference type="HOGENOM" id="CLU_498859_0_0_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184:SF11">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184">
        <property type="entry name" value="SI:CH211-189E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="546" mass="55198" checksum="CEE93B7CA7576760" modified="2014-03-19" version="1">MTTTIFQAANDGNVELVSSLLDQPSLEIDARDEAGLTALQYAVRAGHIQVVSQLLAQGANALEVVNDDALKQNPELAAVVNNALQHTQSTAFQTAPVVDSHGGKQLPDGTVSYVQPPSYQNDGQQQQQQQHFVHQHPMSHPAYPFQPQHAFFDPSHNPEHRAHATKDSSSGSLPPPEVARMIPCRFFPNCRYGENNNSNNTNSNTNSSAKESSSAGTAANGENSSLPATPRDVSVSTSPASAQTTIAPSNQKNDIASKPSADRTASRAETADKSTAAAASAPAKKEAAVKSNAATGSSTATKSSGSNAASAGKSEAKAENTSNGKRAAASAKGDEAKPAAAAPAGQGDRIPASIPSKPMVNGNGSNGAANRQNGAKPQANGVQAGKGNHNQNGARSRANQGSNGRANGQGAQGNAGQKKPAPQRLPNADDFPALSNGQGQAAAAPAPVAAATTNGAPKANFSAILSAPAPVKKQPEPTKETEAAAGADDKPAATPAANGEAKEAGESANDADAKTSAPKQASTNGSGAAAPMMDFAAVVQSNPVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRS5</accession>
    <name>W3VRS5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRS5"/>
    <dbReference type="HOGENOM" id="CLU_953522_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="292" mass="31347" checksum="757F764B8FE77981" modified="2014-03-19" version="1">MPRTSTVGASLCSPRESSEPVWYAEYSSNRSVKPGRGGQPHLSHLEGNAKHTYGYRTASYLPPALASSVGLRGFSVHRFGMQGKSTCNVVRARKAHAIASADIRRASKRMNMRLPAVCWETKVGKAYYASPSAPVNIGSMLGVQEGTKFSSMKPSVSPKLRHAAVPVGPCPADLGSRSMIAQASSAIVGQAKPSPNGGCVSILSISYSMAIRAPFCLCSSVKRAFPAGNVHLGISACTATFHSQPERSSRIQSQGSEKRLKSALSCLQAERSERFFRQDLHNFFSKDARLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS19</accession>
    <name>W3VS19_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS19"/>
    <dbReference type="HOGENOM" id="CLU_1434996_0_0_1"/>
    <dbReference type="OrthoDB" id="10669778at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="189" mass="20509" checksum="A0A937A35BDEE344" modified="2014-03-19" version="1">MSHSDKQQLNQEQHRQRSSNRNTQASLGSPTGEQNSQPQPVEETPAVPSARPLPPPSPQQQQPAIPVGPKPVRAETQPRLAASSAPKMQSRTRKQARLKTKQTSNEQQVNQQGLPPLASAISTAPQVTPTVLPNGLAEARFLPLDHAPTATSEHMFKKRVDGDSSPSPTSICIDETSERMPCDSFNAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS62</accession>
    <name>W3VS62_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS62"/>
    <dbReference type="HOGENOM" id="CLU_1652902_0_0_1"/>
    <dbReference type="OrthoDB" id="3357587at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="160" mass="18283" checksum="951BE40D8F00DFAC" modified="2014-03-19" version="1">MAQLPPYLVRVVATILTQALTRKLAQSPLFFRIVDRMIHEIDHVPHRMQGRHVPTYQPPIGMRESEWDQDHGEPHNEPSPFPAVGAKDGKQVGGDGTSGAKMSFEEAQRQRARTSYQQSQRIAQRDRARAQAEQKTAQNDKVARELRELQDKLRELRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS82</accession>
    <name>W3VS82_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS82"/>
    <dbReference type="HOGENOM" id="CLU_829296_0_0_1"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="335" mass="36162" checksum="199D55FA1A483A1D" modified="2014-03-19" version="1">MASSPLLTLQYASLEDVAQDLDMVIQSASADQWSWQGVNADEEDAWSRFVQDPSSVLAEEAESAIAGMSGKIQVTQDVALSFALLSRGGWLDGSTIEAVVDVSAPTISSQGVATIKEALVGRSHAWDDDGVESLFLFDLLTTAQEQVASADLAPNAESGGREQGLESVPNTKQSESPTSVEMSRALFWSHHLKAPSKLKDFNNWCPELRIWGIVRTGYPGYLCFEGEATAVAEMVRRVKALQWHAIQLRVNETWTWHPSSSGDAANLAPLEQALLSCALAQDHPANTEVGKVRTGCQVLDSLGELVQRLRECGLPHDEISDALGIRISTAQASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSE5</accession>
    <name>W3VSE5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_01018</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_6_2_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="643"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="828"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="95"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="562"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1281"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1281"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS64553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1324" mass="146491" checksum="AE1BF51ABF995AC0" modified="2014-03-19" version="1">MGGRPKAVDTLHCAAVGQRNVIRREAAMPSQLEEEVAQRLATSLSLPNANQLLAQRVIALSRSLPTDKAFVNAARAFGRFDEEFLVGLRSFISSHADQSSGTSSNGARFDAPASSTHTRQPERAGLATLGGEKHVFRSNKPKSSLSGAAAKRADTRDAPPSHPSDANHSAKRPRISSTQLSHLDEEPDTPAPKATTPPVFKAPARPASHAQAQARPRGSETPSHPGGLTETAARRLEEHRRKRAMAAESSAKAKQAASSSTASSSTASAASSSRIADARSDPRQPHGRNQDSERYRRDNARDHRNGRTQHPDTAPPNHFDRRTWDSTPRNLPNRDDARDRWTPRMSNTPGSSRRSDGSLASTRSAGSRRWDETPSRRARSPLPSDFDDNAESENTDWDQDNRQLDREWYDMEEGGVAADEEHNPFAQYEDMAGQVAAPLAAKKDKVTARQAQYNADSDAWERNRLQTSGVGPRSAIDLDNMDDDAESRVHLLVHDLKPPFLDGKTVFTKQLEPINPVKDGLSDMAVFARKGSRLVRETREKAERAKAAGKVAAMGGTTLGNILGVKADDDQDDPAPSQPARTNGVQTDKAATAEATDENEGRGDSQFAKHLKSSTGGSEFSRTKTLKEQRQFLPAFACRDDLMRIIRENQVIVVVGETGSGKTTQLAQFLHEDGYTQYGMIGCTQPRRVAAMSVAKRVSEEMECKLGGTVGYSIRFEDCTSSETKIKYMTDGVLLRESLNEGDLDRYSAIILDEAHERSLSTDVLMGLLRKILQRRRDLKLIVTSATMNADKFAAFYGGAQTFTIPGRTFPVDVLFSKTPCEDYVDSAVKQALSIHLSHPKGDILVFMTGQEDIEVTCQVIQERLGQIDDAPPLLVLPIYSQMPADLQAKIFDAAENGERKCIVATNIAETSLTVDGIMYVVDAGYYKLKVYNPKVGMDSLQITPISQANANQRSGRAGRTGSGTAYRLYTEMAFRNELFANTIPEIQRTNLANTVLMLKALGVSNLLEFDFMDPPPQETMLTSMYQLWVLGALNNVGELTPLGRKMGEFPMEPSLSKMLITSVEYGCSVEMLTIVSMLSVPSVFYRPKERQEESDAARERFFVAESDHLTLLHVYNQWRNNGYRDSWCNRHFLHPKTLRKAREVRAQLEDIIKSQKLRLVSCDTDWDGIRKCITAGYFHQAARSAGIGEYANCRTGIKMHLHPTSALYGLGYSPEYVVYHQVVLTSKEMMNTVTQVDPHWLAELGGAFYSIKERNATTGAARAKRTGDLDRLASIEEQMKKDRSQQLEHEKQERERSQLSRAAQTPAIATPGATPMRSRGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSP0</accession>
    <name>W3VSP0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSP0"/>
    <dbReference type="HOGENOM" id="CLU_506339_0_0_1"/>
    <dbReference type="OrthoDB" id="3366946at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009511">
        <property type="entry name" value="MAD1/Cdc20-bound-Mad2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681:SF1">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="538" mass="57770" checksum="F4D5866499916F64" modified="2014-03-19" version="1">MASHQSAPQDHLRRRGPRTQGARCSHSSRLDVPLLDMGSTMTAQLAHERNGLLLSHAHSSDHSDRSRILSALRRDSVDLNKAQSPGHCNQLTAKLAECLVHHVLFAKGQLPEPVSLLRKRRQIDAAESRPSTGKRSPSSSARQRKESKLLARLDQLRLHLEQAATQLATFVATNGEGPSRYPFPGTLGAVSPNDLRLLVVIGASAAMPREVFVLDLIQAIGRCTSAHAAAQHLLSSCDDPDDREHESSTGNDDGHACLAHLGSDASEQQRSMARDKTSTNWERKLVRLLVSDERLENFMASPLSPTRVHLFLSAPASFRCAGWSARNHLDFDLDALCEPTSDSETRWENSACGSSSSVADSGLDDSASEHVGESSMSSISQDSSRPPSAADKPFGVGSSPNEWLPTCSSPLAATGDAQSLDVSRTGSSLGSSTVYGHVDSSVEASEPRRRSREPKAGSLLSRNLIRARTRHASLAASDSSSVRSLPVSIKRAPRCAGVQVDFTDPAANAPSAPAPSPAASTVERRCWFQCDAVLEGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT40</accession>
    <name>W3VT40_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT40"/>
    <dbReference type="HOGENOM" id="CLU_010458_0_0_1"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001292">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000938">
        <property type="entry name" value="Probable periodic tryptophan protein PWP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002558">
        <property type="entry name" value="WD40-repeat-containing subunit of the 18S rRNA processing complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="482"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="762"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="899" mass="98608" checksum="9976BC2EEEB956BF" modified="2014-03-19" version="1">MKSSFKFSNLCGTVYQGGNVVFSADGDSIYSPVGNRLSIFNLVRNTSTTLPFETRKPIARIALSPANKAIVLVADEDGRALLINTVKRSLLAHMNFQRPLRDAKFSNDGKFLAVTFGNQIKVWKTPSHLAREFAPFVLHRTYTGHFDDVLSIRWTQNSRFFITTSKDMTARLYSLDQVEGFRPKTFTGHRDAVIGAYFSKDEKTIYTVSRDGACFTWQGKQSEDENDDMREDDEEAWNPAEGTKDGSSSKQADNAVGLTRWGIAAKHYFMQTGTKTVCADFHAHSSLLVVGFSNGIFGLWEMPDFNPVHQLSISQEKITSVAINASGEWLAFGAHRLGQLLVWEWASESYILKQQGHYYDMNTIGFASDGAVAATGGDDGKVKLWNTASGFCTATFSEHSASVSCIEFAKQGQVLFSASLDGTVRAYDLVRYRNFRTLTSPEPVQFTSLAVDPSGEVVCAGSADTFEIYMWSVQTGKLLDILSGHEGPVSGLAFSPDGSGVLASVSWDKTVRTWEVFRTTQSVETFTLNSDGLAVAFRPDGREICASTLDGFLAFFDPLEGKQLGLVECRRDIAGGRKVNDKVARKNNASGACFTTVCYSADGACILAGGNANYICLYEVRERVLLKRWELTKNLALDGTQDKLDSRRVTAAGAIDLVDDREDEADLLPTERVDQSLPGAQRGDATKRTTRAISRAKCVRFNPTGRSWAAASTSGLLIYSLDEQAAFDPLDLDMDLTPQAVREASQRGEHLLAVVGACRLGERPLMAEVYERTSAADITLVSQQLPLVHLPTVLRLIADRLQPSSGSPHVEFHLRWIAAIFAVRGAEIKAKAANEYAPVLRAVQIALNELRANVKRVSDENLYSLLYVWNGIAKAEDKAAKKASQGAASLGELMEVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT51</accession>
    <name>W3VT51_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244655_0_0_1"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="1216"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="818"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="873"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="947"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="881"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="954"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1186"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1658" mass="176743" checksum="AA373B5C9E3704C4" modified="2014-03-19" version="1">MSASQVTPKANPVQLPAEKSLPPPPPCTDHSDNQPGPSSSAFPHYASNTIKALPARPALARSFTDHASSESKPLIQHSVAPLATRSKSAGNTASFLDLDSESPEAQVFPSNAAHTRSSDVLQAEPARHAPSHPEASPQQPFYSPCLSMSQSPNRRSAQLAGTISATLTSSDRRAPRPSLPAQWKSRAPFETNAPFVPPRFAGADPAALPEGVGFSTPNSFHDHSGQSSPASQRLSSHHTYFSSDYSLRNSASTHTSIWTEPSLASGNNSPASRQYMLKSDASPESLHLRSHDAAESTEELELDESKVGLGITSDVEHDTSSRRSSAALVSPSPVLPASVKAFQGPFSHHRAPSWTRRLDLAPSSGMPSSQLDQILNMQAIGGARELGLSVGPHMQRALSDVTPVSGLSAQSGDAIASAPSSSLLGPSIPLRRDSRVRCSSDSVNYHHSTPPRASRHSPSLSVSSCASVSGRFTPVLTPASSGFLGGADLSALQSPPRSSSLRHSPSVSSLRGSPSLVRERSQRTPPALAPIVMGRSSSRAAFDRVSASDEARMLSAADAQQTLDLASGRNSPSSSLKEPSLRTTSAASRTRRASDVSINSFLQNAEFSHIVGAYASRMRWEEGLYDFDESAETEGDESRAVKTAEEGSATIVQGRHLTLAQIDAETGPNTTHLLLGGNDAEGLTEVLERVLPLTTNLLVLDLSNCNLERLPDAIGACIALEELDISGNAVEHLPDWILNLRALRTLSADRVGLHHLPSSLIQLQELQRLSLRNNELVFLPSWLHRMSKLSNLFVEGNRFGGPWQDIVAPLLGGGAARNDSAGEAVPQHPHASGNGGWSRHVRQRSSTQSPLGAVPERPLMSRLRSANDLQTMLSSQRGGQDSPNSNPDISSNDSGYVSPVEGFSRLATTGREDQYRRQSISEEVDPSVAAQTPGKWGGFLKKIGRKASSHRLGSANQEAATTSPSESRFSSPKAMRKSLRSSGSVARLNSASRSSAAQQMTASQSEPLSPTIALSSLSLAAAVADDHAVGHAPMTPLEVEAPSKPSSPASPPSSALLQPISLDAEAKKARRRSFLPVHAFASAAGGLPPHLAPASVAAAAGTAQEEMDEESLSKHRNRLRALMHYLRDLDDLTAVRTEAASFVGPSKRTLSHLRDGEPLSRTASMHRAESSNPSTKSRDSGGEYVASTAASSISEGASSEPTRLSTARCSKDDSVRRFRIIAEIVSTERTYVRGLSELVDVYVRPAMAPADGNSGVPVIPPMEHRAVFGNVEALLQFHRTVFLPSLLAVTNPILAHDQEAAGDLSPDETAAIAEKVAAVFSTHAAFFKMYTSYINNCDSAQARISAWMAPSSAGNGGGLSLRGAPGYSALQAFGALSAQQGAATAMFANGTGSGQASGASAGSSILGSDSALTPSQRKKIRTFMKRCRTHPRHTQINVESYLLLPVQRIPRYRLLLEDLVKSTDTARLADGDALATALEHVTQIASKVNESKRQSEQDRRLLAWQYRIRGPIEGPLVQPHRRLLKDGTLQLKRTVRRIPGFVRSSRSASVSRARPADVSTRGSEQVLSADHLQQTTEDQSMALILCSDVAVLCVDQSQGRDVQAPVLLRSVLKLTRPVEILGGVNLRLVDRSEILYLAAGSPDQAVAWKTAFDLHFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT81</accession>
    <name>W3VT81_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione s-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT81"/>
    <dbReference type="HOGENOM" id="CLU_039745_1_0_1"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="348" mass="38355" checksum="A9098452E51D1C04" modified="2014-03-19" version="1">MATAQPNTRVIVYGYGASPFWQKITFLLDHYGVEWTQVDVPPVMPRPMLSKLLGITYRRIPVVFIDGHAYIDTTAASLALERTFGKGDRSLLRQFPALQLQLAVHWAESALFRLGAGHLYNAPLNEVFVKDRQSFMPGASFEGEAMKKRIPFIRSQLVASMEAIESQLGEGRGKFLLGDEPQYLDFCVFTPLNWVQTQLRTGEDLLPTVSAKNPQQDWTKFRFPKTLAWLAEVRAYVAKNKVKPGKLSAEDAAKAVLQQAEASSAKDEGALKVSSDDPLAKAGWISGNKGQKVSVTPVDTGRVPQLGSLVGLDNASVTIKIEAQQGKHILATFPRVNFDIRATDAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTA9</accession>
    <name>W3VTA9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTA9"/>
    <dbReference type="HOGENOM" id="CLU_016785_1_2_1"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF21">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="515"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="838" mass="91996" checksum="5E2D40BDAAF93929" modified="2014-03-19" version="1">MQITLLSHSEASESQSDSRTATHTDSTHSQQIPQQQTVPSLTMDHADDHDEHATMTINVEETNRKYASISPAAIALKRLAPDSDSASNNDSLTDGTASMPSTEPSTTPDETGSSSSGISAARKNAKRARTDSAAPLHHARERVQLPHPLGIKPLGNAFLSDRNDRVPSLGLFARFDDDFLLSFITSSFAEDPATLAKLEAVSHGFYTFINATNSVWREAFLLSFNGKMKRWCGSWKRTFIWHHKLSRAVFDDKARESMDGSAFALLDPPAPRIQSPYLFSDTLYHPFRLASAPLDHLVAPACRLYNPIPKIDLAEPGSIAEFKLKFAYANRPAIVQNAMPPKDWPCREWSLDKLAQRWPNRFFQCEAVRSRLPTYFSYSRGMQHLHEQTWQQLLEDADGNPDVAGRRDSATISNDGTPSADGTDSPRDRTALPLQNTPYTVTRAGTHLYSAVADEGDSTFDPYAVPDESPFYLFDASFADDPHASLEWRVPKFFQQISATAADAQADHDSSAISAPAADAQADHDSSAVRSDLFSLLGRLRPDHRWIIAGPARSGSGWHKDPNATSAWNAVLTGRKAWMMLPPHVTPPGVFVSDDEAEVTAPLSIAEWLLEFAHETRRLYGPSAARAEDRLLLEGVCEEGEVLYVPSGWWHLVINIEESVALTQNFVSPPELATVLDFMKNKPDQLSGFKRTQLDGPVEAGVVALAPGRQAASIGQSVAGAQQTQADDADDDCDGATFDVFALFADRLQRFDAALLDEALAEVEQIEQTRKSICLARRVAPAPKTAARRANAGPTWWEKLKQHEAAASGDGAEQQASSAFSLSTQLADEQLELDDVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTD4</accession>
    <name>W3VTD4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTD4"/>
    <dbReference type="HOGENOM" id="CLU_305455_0_0_1"/>
    <dbReference type="OrthoDB" id="10671876at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="971" mass="94886" checksum="A80277689670ED94" modified="2014-03-19" version="1">MTGALTSRAGSGRRSRDAAAICPWRIGRERERRSNVDMLAQKAALPHPALATLSNFVFAYLRRHLSTSDRGGKRPRVRSRLAYCGSGAAVCLMSILGADKALYRIRIFNIPAMKLIPIAASFLLLSITQIDALPLPDYALSLRDLRARTEQNPLSTGYSRALPSHLTGSNGKYDGNSNSGSSNGSNNGNGNAGAFNGNKNGNRNAGDSNGSGNGNGNLGWSSFNGNKNGNRNTGSGNGSAVGNENLGSFNGNRNGNKNIGSGNGANVGSGNKGGNGMSNFNGNFNGNHNVGDRNGASVGNDNKGSFNGNFNGNANHGNDNGASVGESNVGSLNGNLNGNSNQGDGNGAVSGFGNTGKGNGNFNGNLNHGDGNGAFSGWGNTGDANGNANGNGNHGGSNGAFTGFNNIGSSNGNGNGNNNRPDPGNPGSGNGNGRNTGNSNIGNENGNGNGNGNFGSNNGGLGTGVYNVGDMNGNGNGNGNVGSLNGGRDGYQNQGNNNGNWNGNGNQGDLNGSNNGVSNQGDKNGNSNGNGNLHGSSQNGLTNGHDNVGNDNGNRNGNGNTGDLNGSTSSLSNQDGGNGSANLGDHNGNDNGNYNTGNRNGAGNGRNNFGNSNGNQNGNHNTGDSNGVSNGADNTGSSNGNKNGNNNIGSSNGSSNGIGNIGGNKNGNHNGNSNRGSGNGNSNGSNNQAGSGNNGNWNGNANVGSGNGSGNGGLNTGSNNGNDSGNRNHGDSNGLNNGNQNSGSNNGNGSGNGNTGDLNGNNNGQQNSGSSNGNDNGNKNTGSSNGSDNGSGNTGSGNGNHNGNNNVGSNNGSNNGNNNVGSNNGSNNGSNNYVVDSTSSTAVGSGNGNANTSSGNGNGDGIGNLVIGAGNTVGSGNGNSNSGAGGSGNGNGNGNIILGSGNTVGSGDGNGSLSASGNGNGNGNIILTNGNTVGSGTNQSGTGNGNLYLGNSGTVIGAGGSNGNIYLKRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTH3</accession>
    <name>W3VTH3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTH3"/>
    <dbReference type="HOGENOM" id="CLU_484941_0_0_1"/>
    <dbReference type="OrthoDB" id="2555373at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="562" mass="60778" checksum="C1E22EDD19B3558B" modified="2014-03-19" version="1">MPPFLSTFRSRTNSLLETITGVIPDSPPNGTFKDRSLTCRKCGNRFRDALELSSHFNLLPHHSDYSDSHDYASFIRPKARRTKIATAPLVDTAEAAPVTAGFSEAEAFYAVQDKENRIDRPALLRKFPTLSNLATATSAEQQAMQTGTDYADGDGPPQSPSAKAKGKQKAFPLLRREDSYPFGQPLYSSDEDEDTKAPGPSNAPPISSLRSRARSATTQALMPEPALPPRPRISTSSSVASKSTTSRRQAPPLPPKIPAFDWDNDDAASIHSDASFRTAGSTEYADEKAAFKKDSKSGWGTSKASDRDHSANASTSDMRRHDLRPDNMRHISESELLLHSADAPDYDAPPSYHELHGDTDPFDDLTSRTGSASRPHASRRAHSRPEGFASMPTSPINRLHTGTSQRPRRSTNAWLASPSPVFPVSFASASHPWSTGESDLYSSNDTKPKLDASLPPLAASSALSSPASPSSPRTPFAAFGDLPRSSSPFALTLPNPSQITSNARSSEAGTRRKRITSRAKSDAAVPSTRCPTCFTKFASLDKTLEHMDNSDCGAIEFESGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTI0</accession>
    <name>W3VTI0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00829</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTI0"/>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="567" mass="60548" checksum="24F1180A79D0A0EE" modified="2014-03-19" version="1">MSAAAPAAAPLARGGPSQNAFKNADKPDEVRRSNLSAAKAVSDAVRTSLGPKGMDKMIQTSNGEVVITNDGATILKHMAVMHPAARMLVELSQAQDVEAGDGTTSVVVVAGSLLGAAEKMLNKGIHPTIIAESFQKAATKAVEFLTDISTPVELNDRESLLRAASTSLNSKIVSQYSSVLAPIAVDAVTRLVTPGAQSSNKTAAAPASASTIDGAPPVRASRSADAQDNVDLRDIRIVKKVGGTIDDTELVEGLVLAQNVVSGSGGPTRMEKAKIAVCQFQLSSPKPDMDNQIVVNDYRQMDKILKEERQYLLNMCKKIKKTGCNVLLIQKSILRDAVNELALHFLAKLKILVVKDVERDEIEFVSKTLGAKPIADIEAFTEDKLASAELIDEVQQNGARVVKITGIKNMGRTVSILCTGANSLVLEESERSLHDALCVVRCLVKKKALIAGGGAPEVHVSRLLAQHSQTLKGMEAYCFQAYAEALEVIPTTLAENAGLNPISIVTELRNRHALGERTAGINVRKGQITNILEENVLQPLLVNTSAIELATETVALLLRIDDYHLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTJ3</accession>
    <name>W3VTJ3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTJ3"/>
    <dbReference type="HOGENOM" id="CLU_363365_0_0_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="693" mass="74433" checksum="B2199C44A0694A62" modified="2014-03-19" version="1">MATTRPTQRPGGEQAVASSSRNPPLQRLRSGDAVSTLQSSAVAAMGSIRTLASVSSSGTSLHPIAPKRAIKVVLIGDGGCGKTSMRNRFLTNSFFPSYRATIGADFITKTLPIDAANPDGEKATLQIWDTAGQERFQSLGSAFYRGADAVIIALDATKDPDETMQRVKSWYEAFMDKAPGPASEAERKRFCWICAANKVDLVDGQATRPLDRDAVRRTLNALVPAPEEQPDWGIDAGQPGTRPSGAKEPANPSEVLSRPDPNTAQAPETPTKQASGASLGRDPGGVTPISMQSFGTVDGHASPTAKVRQRRSDYRLSRKSLSSVAAAAARAAEQEDSSDADEPPHMQNGGTLNTVYATPFGTVSNVAQLSTSPSAKTDTTSRADGTDGGSGFLSSWMRSRSKASQSRATRGHTKRQSIRSIEVFQPSDSDDDRDARKFAFPRGAVQTPPRSVRSSSKGERPRVDSTMSLGAPSVYHTPRSSTFFSVSPTPRTTLGLPSMRTDTTSSTSQSVDSKAQWHDGKDAKLKHRVSMASSSTASVATVKADAGRGTNPILRTPKSINDLFQPQDSAATLEEHEEQEEVQEGMGTPRARTPSTLSLPVEPVEPVAVPSEVEQGFTLFYTSARTGHNIERMFQHIATRVAAVHAYEQSLQTSEHEAAGDDERDRRQSELIRRTIRIASGKPPDKSWYSTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTN2</accession>
    <name>W3VTN2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTN2"/>
    <dbReference type="HOGENOM" id="CLU_418662_0_0_1"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF4">
        <property type="entry name" value="F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="667" mass="75120" checksum="9BB5C8439DFDC391" modified="2014-03-19" version="1">MTLQADPATALPPETFLHILSFLQPPALLRCSRVSQTWREVCTDEALWRALSLRLGYCQLDRRQQEQQSGVAVVASVLQYLDQAPDAALGLDLLRATVTRYRSRNTTSYFDECDSWRALCCQLWRLGCNWLAQEPTELQPPSIAASVATTDHNAAGSSTSHPARSSSYLLPQRRILHEKPYGQSVWRCKLDPEEQTVIVTGQAGGIQVFDRSSMQLLWHIARTATRACPHLEFSRGWFVFDRPGIGHFEVWRSERLVPDLGRPPDRGHYQRFTVLSSTRPVRAYRFQFPYLCAASQDGFVMLWNVPDEELIQSIDFRDSPHRDGNVNYIDFDDDFVFLNGVGAKSVSVYSRRTGRQVWNMGQHFAAGRTPPAPWRVQRAPSPCIDNAGFVRCELKPAPPNLWQAGPNTMNLAQLTMTPYQIWSAVHPDLKTKTLLILGHGTVLLLRDYKKFFDDPSQPPELFAEIEFENLQEFFEREVIGDGEDWSDLGWNSRHLWELLGDAQLTVHEGRAVIVNEGALILDLNVEAAALHACGNDQDKLPTHIVREQHGHGGEGQEQAEDASSSATPSDADSPNAGAASRQEAPPLLVYRAFNQPHTYHICSSVQMDEVGIYYTVDQPRREGGVSTDIDLLSEPWLGEKHVLMHLDFSQRQQVVPKQPPNPVSNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTP8</accession>
    <name>W3VTP8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_00824</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003290_0_0_1"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="756"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="392"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="573"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS64855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1390" mass="151033" checksum="D1DBBF0294AA270B" modified="2014-03-19" version="1">MTMGVAGSGRRGARRQPASTRARRSQAGSAASFPFIRHFRSRGESLFQHHGRWISKHQIRTLLLCSLVITSLFYPAVGIYFWASKGGPGVSRGDAKSVWRSLSTPFMDSFASSGRKHVNSLSDLRMIWDDAPDLRAIDIGDARAIFDLQATQIQPAHTSAPAVSRPRCQSVRVEHVFITTDDVMAGRGPRFGVLEKRILHSALQLQKSIESELRGRYDPDSVELQLDCVQVRPSFPGRPSSHELSQPSNTDDACLTLSPLEYWNLDSDTILAEDDPAQLVSHSTLNRTLRGVPISFSTTLAGRWHLFKRLPRAEYLAFTFFLRQDSSEGGCSDLSASTPPAARPTLSHSRWHELLNRVTGGQVRLIASPESVLHSLVLRFSPEMLSSRRRPTHILLLTAYAFVILYISRGLIKLRKVHSRFGLAFTGTTQLLISMVMSVSICALLGIRLALVPWELLPFVIVVVGSENMFSLTKAIIDTPLSLTVSSRIAHGLGKVGVPITLTTLADILLLLVIAFFIGVRAVREFCIFAIFSLMMDWFLQMTFFVTVLSIDMQRLELADLLTQGTRLTRKQDSALQMSDGSTTQDSAGSIDQATGDDQPDGTLRKQVRSTNIVVNLLSQLWKARSARTASLTLILVYMSGLYLYYGTGYPSLRQSSFVLPADWDTVRQAPATNAAFDPFGHLDAKTGPSLPWWTSSPSADLWTSLNPLGASELRVHVEPWTILSLRSSNDAQSPPSMSTFAGWALFRPRIRAVIWFAKLVVLPISGTTALLWMLLLYLLKDTELLDAQRDKSEADPSEGESGSLLNDSAPHLRPHTSIITNAHPCDVEFLVHDGALAASIDNGGGIRIWSVVAASGGDKGVEVMGSLGRTRAASDASVVTAAAMSAEARWLSIGYESGRLHFVSTETLETIWDHVPDSAVSPVISLILQHHESMHILESATAISAHRDGTIRIWNVARKQVTLASAQTHLDPRLRWRSVHVNVAHHQGSAHGANKPSGSCDPSLLAFATTDGLFHIRSVEPATSSTKTVFTLACEDRSRVCSALLCQLASRPPSADEAALLRSTLVLGFANGRVRLIDVETAETISSVDLDDGPVTGLCTIDAGDASTPALIAQSTCRSSLLIIAGGSMNAASLMDKSGSVHSSLAGYLSGSPLRIRTPNGSRTNAATFWADASTPPSPAAELANPLSYPMSSHGSASRLRRASAHTRDRSGASVVADGTSQAAAMSSSLSAFPNMLSPSTSTQKMDERQLRLLGWIRCERGGSFAVGSKPLLIGVGRAQRSPHQSRWEWWALDLRHELTLGRGGELLVPRQPLLLEAVDKTDRDATPRSSLSIQRNGRRDHDVVMDAALSFSRLYPLRGLPTSQRDESALLFGFGGCLGALSVKASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTQ2</accession>
    <name>W3VTQ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PaG_00464</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTQ2"/>
    <dbReference type="HOGENOM" id="CLU_006732_0_2_1"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000001">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="224"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETS65013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="896" mass="93802" checksum="6170C067BED5FF03" modified="2014-03-19" version="1">MQQLTTPLLPLLDADSVKDSALLGALSRVAPVLVPQDLVSALPANIAYLVLAAPALSYDAAADLFDAGAEAIVTADTQLIQQFDAAVAATRFIYLSASGAPPAPETLNAVAGAVITLPTASAIAGAAQLVQATADGLQAKTSGKSLFVLAPSGVPSVDDVKALAKLSASLIAPSSVLSLADEGQQQQGKLDIADAFLAPLTSDRTDGLFATTVVSAAGSASLGLVYSSPLSIRKSILTGSAHYQSRNRGLWHKGESSGATQQVVSIRQDCDSDALQFVVRQSRGTSASGFCHLENRESCFSSATGLAKLEATLKQRQQSAPAGSYTARLFSDASLLGAKLREEAAELADASNADKQHVAFEAADLLYFALTKCVSAGIGLEEIEASLDAKAKKVSRRKGDAKPAFAEQQKAAEAKAKTAPAPTPAAQQPKDADAPIKIQSYRYEELSASQRKELLKRPALRTEQVMEICRPILGAVKQRGDAALLELTEKFDRAKLQTPVRLPPFVNDEVMAKIKPEVKVAIDIAYDNIWKFHKAQKTTFGNKRAADVGAAGTVEANEAPEDGVLEVETMPGVVCRRFARPIQSVGLYVPGGSAVLPSTALMLGVPAQVARCPTVVIATPPRPDGSISPEVLYCASKVNASAILCAGGAQAVAAMAYGTETCPKVDKIVGPGNQFVTAAKMLVQNETDAIVSIDMPAGPSEVLVIADSSADPAFVASDLLSQAEHGPDSQVVLVGIALTATELQAIEDEVDRQARALPRVEVVRQAIDKSVTVIVPDRATALEWSNAYAPEHLILQTASPEELVKLVTNAGSVFVGAWSPESCGDYMSGTNHSLPTAAYAKSYSGVNVGTFEKCITSQALTKQGLRGFGQNVIDLAMCEGLQAHAMAVKIRLDRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTS1</accession>
    <name>W3VTS1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTS1"/>
    <dbReference type="HOGENOM" id="CLU_301500_0_0_1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="814"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="887"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="947"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="956"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="978"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="991" mass="106396" checksum="C1332874CB4D7711" modified="2014-03-19" version="1">MGFIKAENQPSFGPGPVHINPNDAQPGQFAFLPYSNTGFDNIHPSDLGKPGTSDGRSKVARACTECKSRKMRCDGGLPFCGRCITHSRTKSCAYVDPPKRSPIPRQYVSSLETQLEDANRKIAELQALGNTAAGKASSADKPSTAGPALQRRATQPIMPNRSLTGEGPMHSCGFASHVPSSPSKKRPRSMSDGSNDDANDGDLADDASPSSKPSGDAANSTKDVDALGGGNFVSLTSCNAALQIASQLSLGRKSAGPADFSALPTLASHDAAPRSASAGGLDVSCEGLASASASATSAMQMQNASALPDNVNFAAWDSESQRFAVDLLESFFEFHLTSYPILHPATFRAQLQGTVCPPQSPAWPMLVNMVFALGAFERRVSAEEVDVDTVFYERAKQLYNAVLFDKAEIMSVQALTLMATYCQKKNLFSSAWMVLGSALRMAIAMGLHSEAALQARDMPAFDREFGRRLWYTLFTMEADTCVSMARPNGLLSINADVAPPQNVDETAMSPTSDELPSEVSEATLSSTLAIHAKFASKISMPLQARLMKGPNPTIEEVRAFDLKTEEFVDSLPDYMDDGYAGPRPASFSVASARLRWRCNNFRMVMFRPFLLSNSVAAAAARDRGAPRPALRPAVKQAIALCRRMASNNIRSISAFWDSHPHNQAMAWHAIYFLTQSALVPLVSLLDEPSSEEAREWVSLLQTCVRLLVDMGRITPIGAKCKDAIENLAGDLLRSSDEERESMLLSKWMNEAHSTSVGSSADVDSLMWSSHLMAASGGASDGHAFGGVVGHPTDPSLTMSLDSASSDGMSTGFDFARGVDASPGDHRSSVAESMDPWATATATARPSTASQWSENEASSLPEREFLHRERLDQWFGLQASHLESNHAAPMAAPAALPAAPDAAQQHQANLDWQTAADPTNWWNVQYKHSDASPSTGFMFNHDVHNGNSHHGHGHFGAGAPAESSQVAHHAHAHAHAHPQAHSQHGASHQHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTY2</accession>
    <name>W3VTY2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-oxoadipate dioxygenase/decarboxylase</fullName>
            <ecNumber evidence="6">1.13.11.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-hydroxyglutarate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.93" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTY2"/>
    <dbReference type="HOGENOM" id="CLU_026640_0_0_1"/>
    <dbReference type="OrthoDB" id="8300246at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.80">
        <property type="entry name" value="Uncharacterised protein PF07063, DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="HGLS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047869">
        <property type="entry name" value="YdcJ_bac-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479:SF2">
        <property type="entry name" value="2-OXOADIPATE DIOXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="HGLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="708" mass="77476" checksum="FBCE371551C43FC0" modified="2014-03-19" version="1">MAIGDTRRPIPHIHSTAPYLTQASSLNAPWLPVSRSPDKLPCASIGGASYDCQHARDAQWARTAKPEAIVPPVMNASACRYTFLPSSLSSPPRPSRTRHHHHQLHHLDLPQPSLARRSTERCDVHPSVAQLYLRTLPPKPRRKKSTSSSVEMQAGIATTSTAGRAKSPPGFNPTASFVHSQQQTFPALSATDSSEVSSCSSTSSSRRSKRVTSTQLRALLASSMSSMYQTEVPLYGELLDIIRTVNASCIRRSPHAVSDDEISRLNVERHGAIRVGTPQELALLARIFRVFGMMPVGYYDLWKDAGLPIHATAFRPVGADNLARNPFRIFCSLLRIDLIADPTTRELAQRLLASRQIVSDRCIELLSKAEDTLPPAHSGVDEVTLEGLTRVEAIEFVERVVDIFAWHSDTPVSLCEYQLLSRTHPLVADIVSFRGPHINHLTPRTLDIDEVQSSMIARGIDAKQVVEGPPPRHCPVYLRQTSFHALSERVSFLGAPEGVEHGRHKARFGEIEARGQALTRRGARLYDELMARTARVKKAAESQASTPLSTEDCQRILAQVFRDGFVDDAQAMMRGALAFFMYTVRDGALAKTMAAGTHDSASLAAMVEAGALAAEPITYEDFLPASAAGIFQSNLPQTTASATDKPEHVVAEMDESAARKRLEHAVGGTMLDYFALYAEQQALSLRTVAAQLDVDWTALLAQLDTEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTZ7</accession>
    <name>W3VTZ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTZ7"/>
    <dbReference type="HOGENOM" id="CLU_172736_1_1_1"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8207" checksum="6BF97F45F2CECC75" modified="2014-03-19" version="1">MSYTIAGRKILNEHIALAVLGTYGAIAVSQMGGSKQATPSASPDAKAANQPPINASSSDEEAFIKQFLADAEKESGRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU05</accession>
    <name>W3VU05_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU05"/>
    <dbReference type="HOGENOM" id="CLU_860856_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="323" mass="34838" checksum="EE63CFB963E5162F" modified="2014-03-19" version="1">MAMHGGSLQPSRASAPPFRLPLQAAPSTRSMLTMLSVWIQRTANAPPIDAGQAYEPEGGVTDQRCADHAFDAQTSSGSFGICALSLFLPAERFWDAQPHASSLLDRPPRARTVPSEKKDAEQARAGWCCGCTEDFSCSSPPNQHVPFGRRGHGLCAFCLLPSSSAATCTLLASPIRDRQMAGGSARPPRPPLAPFRGIRAGGTLACSYGALISGHLPDGHARMPYLRNVSTIVRTEEAKMRKIGDEEPSTADEIRFELWRQAASSLGSSCTHRTSSRPTPPTSSSRPPPTSTLRVQPVSPTTTALHHRIFLRIFLRIALRIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU10</accession>
    <name>W3VU10_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU10"/>
    <dbReference type="HOGENOM" id="CLU_079971_1_0_1"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="177"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="301" mass="32639" checksum="A4A14B2612452A29" modified="2014-03-19" version="1">MPMRIEADGQNCCCSTTAVGNCKAEGGGGGGGSSARASIPELDWASRLGSSCGSLLHHHHHKHPLLHIVHPTHPLGMSASASREAAASLSNRPQQGTLALAYRRSVVALQNVFGLNPDSQYAEREPLLSNHDGDDNTPSGANGYGAVASGSRDAGASSRPRIRKPKKIVSQSKVEAKVWFANERTWISWLRVSVLIGSFALALFNSDAFFQHHNDDHPGHHNQYLSSGNIKMFGAVYAGIAVLTLLWGLYSYQRRVTLIKTKYPGNFDDLIGPPLICAALFIAVLLNFIIRVKQRDYEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUB8</accession>
    <name>W3VUB8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUB8"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="576" mass="61300" checksum="A6DDF344777418A7" modified="2014-03-19" version="1">MDPVHTAATTRSPSPAVDAHSLDERHSVGHPSSEKSLGHALSNKAASHDGESTPTTEYPQGAKFYLIMVSIVLTILLVSLDQTIVSTAIPEVSNQFNSFSDVGWYGSAYLLTSTCFQPLFGRLYSRFPIKWVFVAALTIFELGSLICGVAQDSTTFIVGRAVAGVGMSGAYSGTMIIVTLISPVQMRPVLMSIVGGAYGTGACIGPIVGGAFTSQTTWRWCFYINLCFYPFVAVAILAFLKVPNRLQTKSIINRFVTIDWLGVALSMCSVICLLLALQWGGIRYEWGNSKVIGLIVGFFVIALAFAVEQWYLGDDAIIPFRLHRQRTVGFGSLVNFCIAASYFGLLYFVPIYFQSVRGSSAIRSGVQTLPFVVAVIVATTLSGGLITKFGYYIPLLLVGTAITAVGSGCLYLLRPDSSLSMYVGLQFLAGVGPGIAFMIPFSAVSAALDPSDIEIGSAIVTFWQTLGGTLFVSVCQAIFQNEFVKSLGAIPGAPTEAIVAHGVSAFRAFTPSSILPQVELAANLAVNKTYLASVALGVAAFLAVFGMELNKRILPPDQQVQGDAEKDAAAAGLPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUK0</accession>
    <name>W3VUK0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUK0"/>
    <dbReference type="HOGENOM" id="CLU_756759_0_0_1"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="366" mass="40184" checksum="C44685C40F005CBE" modified="2014-03-19" version="1">MRGGMETFDTGYGATPSVGSMSFHTVETELSSHQDSLGFEVKRLPNGLRTQSRLSMASVSTCTPVRATCPPSPIHHASSTSTDSTYTATAPARESNKEERSSWGANFWCVVQDPGGGERFFANPDTGECRWTLPQGSMVLPPSDDGQWWQLTDAQSGCSYYFHTRTHATQWTRPDAQLVIPMTAVQLKLNQCTQSSGRVRRVHSLPRKAAVVERARDSIVSRDQTALAQARGSPSLRSDAPQRRKPRTAPTPTRPPRIESNTLAAAPTVAIRRVGKGLAHDAGHAPLRARRSMPVLKPRRAVTHLPPDLAHALTVPTRHPQQHPKPVPAPAPAPLPIEPKTEAKLPRSRSFPLRWFSRCKRPPLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUL7</accession>
    <name>W3VUL7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUL7"/>
    <dbReference type="HOGENOM" id="CLU_1408564_0_0_1"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21333" checksum="64E3AFCCD329EBA5" modified="2014-03-19" version="1">MSMLRSAVARPLRTAALVPGTCLPPMNLLCRSFASTSLGQLQSTTPSSKTESSGSTASTYSAILDSLADSYEKTTRGAGARLSRPSDGRRGYVADLEAEWATRAVYGEQSWPATPFSGRSIRVTPSADPARAYAQLATLLKKNNVRGELRLQQRYEKPNEERRRKKSERHRRRFADMVRKKVQLVMAIKARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUS2</accession>
    <name>W3VUS2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUS2"/>
    <dbReference type="HOGENOM" id="CLU_034384_1_1_1"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="90"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS65284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="414" mass="45741" checksum="689BBE93255C0338" modified="2014-03-19" version="1">MQHEEIGSDAKAGPSSYHAGPAIQPPPGMSKNAAKKLARKQKLDATKHERRAAERLKKKENRRVRHLAAQQDAELNDLDRATDASQPAAKRSRLEHAPSQAATKQFFDARLVIDCGFDELMVEKEASSMTQQLMYLYSANRNAKMPFGEIILTGQDAPRDCLRDVHPDQLSLVPDAASTSQPETQAETSFASSASIENNSIGRAMDGKLRGVWRRWKRVTIYKHGGIESLLSQQLHGDPQTPSLDAADESDHVKKDASGRHPASEEIRQTRHRVRRSDAIYLTADTEDTLTELEPGKTYIIGGIVDKNRYKGLCRAKADRLGIRAAKLPLSQDMMRAVERNLSARGETLEDEVGTAGKAEQSFVGRKVLTVNQVVEILAAWTGTRDWVQALEIALPRRKLKQRGPAAQSTTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUW0</accession>
    <name>W3VUW0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUW0"/>
    <dbReference type="HOGENOM" id="CLU_007383_6_8_1"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000944">
        <property type="entry name" value="Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="49"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="501" mass="55466" checksum="033175BFB701CFA5" modified="2014-03-19" version="1">MHTPINPTQRRQSSSWPLPLSLLDLPPPPPLSEYTTMSTSPASGEAHFVIGGSGFLGSRIALALRQRGEKHVAVFDLHAARQPIEKVDYYTGDITSESSLRQALIQLRDKAGIEAGAKRGIVIYHTASPVAGLGPEIYHKVNVVGTQTVIAVAQKSELAVTKLVFTSSAGVVYDGRSLINVDERLAYPKKPLDAYNDTKAKAEALVLQANSMQPGKLKTVALRPAGIFGIGDRQALPGFFNVLRTGKTKFQIGDNENLFDWTYVDNVVHAHLLAADKLEGAGYPAHKLGDIMISTRVVADDEVKRERDVPTSEARDDTPAGSTDYARKLPSTLSPETLEHELNVRPVIRNRYDQFFHMMNPEVPSAGNPLGEEFRMVEESVPVAGEAFFITNGQPMPFWDFPRALWAGLGHVVTEKDVWKISKDWGLTLAGWAETFSWLTGRESQFTRYKVTYSASARYYNIEKARRALGYQPIVSVEEGIRRSVEWWKSEHPEDVVSPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV49</accession>
    <name>W3VV49_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV49"/>
    <dbReference type="HOGENOM" id="CLU_2251209_0_0_1"/>
    <dbReference type="OrthoDB" id="10273669at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="104" mass="11973" checksum="2FB1C50917D8BB9A" modified="2014-03-19" version="1">MWHRDSGFFTTDDWVNDLVSRHDVDQTSMAPVSFESLHLIQEHQAAQLEHEAFQIPGCESILYSEFVIDGNQVNARIEFDVPQLMLAPTLELICRLPGWITINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVJ3</accession>
    <name>W3VVJ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVJ3"/>
    <dbReference type="HOGENOM" id="CLU_475766_0_0_1"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="57823" checksum="42CBD06180ED6666" modified="2014-03-19" version="1">MSNDAATVLEDASSSHRVYIGDSIGCLRVVQCDPPSALPADFAGPSVRPLILPNFKSHSDQAVQRLATGVLGNDPFVVAMARRNATIDVVQVVNQTLPSSQPSTSAAPAAASELRANVLCTIRETHMKAGIQRFIGLAVGTDGIYSITSSGVFRFTPITISRSGEGEDDVAAELGEPRVLQTLPSPLQHASFYPASDPTHFCYGGEDVPLSLWHVATAVSDPPAAHADTAADMSVESIRADEAGLNSKQRKRKRQLEAKSKARELLWGEVWRAKNLPNDNLSLPRRANITATCILSLQPRSDGDEARGTEEAGGVDGQTFIAVGTKDGLVRVFQPGAASRRHVREARVVPSGQGSVKTLCASTAALDSRTGGVLFVGDTGSKLYALDWQTGAVVYSYNGMAQVGAVLGMAVLPTGNADAEALVSVSSDSLMRLHTTIPAAVAVPKQGESGAKGKVVWQKMIARATGQSVHATPTAVAWNQVVPAKIGSAGGQDDAVWENMQQIRSRANKKHDPNNDDHDEDDEQSESEEEPATRKSTRSGAKKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVK1</accession>
    <name>W3VVK1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">B-type cyclin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVK1"/>
    <dbReference type="HOGENOM" id="CLU_020695_10_3_1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="358"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="452"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="456"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="592" mass="65657" checksum="754523F618B50233" modified="2014-03-19" version="1">MAQPAVRPTATRSRIARPGGIPASRSGDRIHLSEASSSHLAKAKSVAAAGKLRSDSRGVPQRAALSDVSNRVGAARVPAEGVAKPGQHGLRSHNTKSMTRLRDARSRTSTEERLRGPIRSISEQRDLVSGGVQSMDVEAPQLLPPFRGSTSGQASNAAQQASYHADEDAELEDAAAHHDEVDEEELSDVESTSSSDDDTGDDMGAEQASWMASERLDAGGRPESVTSAEDGDLLDFNIDPEGLVSLHPELEEAARRKVALIKSRYQEEVIQPRAARAQAQRVEAVAAGQLSADLAAHEDELIIMGLDPDEVRDTSMVAEYSTEIFNYMARCERETMANPNYMDFQREIHWHMRATLVDWLLQVHMRYHMLPETLWIAINVVDRFLSVRVVSLAKLQLVGVTAMFIAAKYEEILAPSVKEFVFMTENGYKQEEILKGERIILSTLDFNISSYCSPYSWVRRISKADDYDIRTRTLSKFLMELALLDHRFLRARPSLIAAVGMFLSKKMLGGEWDDAFVYYSDFTEEQLVPGANLLLERLLDPGFEEQFVYRKYANKKFLKASVFARDWAYQNHSALLAAAAAAAAAAQHGQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVS7</accession>
    <name>W3VVS7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVS7"/>
    <dbReference type="HOGENOM" id="CLU_1283753_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="215" mass="23803" checksum="7EEB1FD368562191" modified="2014-03-19" version="1">MELFVFRRLQYVRDATSRVESGALCILAIVHGTGGRNAINRLCDAHRIRARVAGVEELRDLVARYRFSASCLAELCRARRAQTGPPATTPLEPTSAASSSERVVLGLLRANNAQPGAINSALQASAVPSSAWRVRHPDAPMAAAEAERTAEATALALTFDLRPLRQAMPLELDYMTTQQRMNGKKTARTEEAHRHWRDRRQADRLAQEETPHGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVU7</accession>
    <name>W3VVU7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVU7"/>
    <dbReference type="HOGENOM" id="CLU_013516_3_1_1"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000705">
        <property type="entry name" value="Related to PEX5-peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF9">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="593"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="721" mass="77503" checksum="12B4C11B68B50391" modified="2014-03-19" version="1">MAFQSMLNGAECSTSNNGLAQMLKHTSQDRSLQHGDRTTAGQPHMSPAGMRQQHHAGPNSDAEAFFRQQQGASLPGTANSAFDMHAMRSELNTAMPAFQRPNAGAAWASQMPRNATPNSADMEAAFARGGAPPASSQWANQFGSSRHQGPAMHHSMNARGDGSGSSAAYASRPMMGSYGGMGMGGMGGMGMSMGMGTIGGMGGGMATMNAPQQTQTSASRFTELDDAKWEEQFKKLDAEQADTEAKGKGKAKQDEPDLLPSEAEQAESIRRELDAIEQELTADGQEANSRFEDLWRSMNARNGVPPSAADAELAKWEQELLNARTDDDETFGYAHPSGGLGGGRYGLDEMAALDGTEDALLDGFGVVGPDGYPRLGNYRRSQQNPFSAHSDPLSEGLRLLANGGNLSDAALLFEAATQRDTPGGTGGEVERGEVDRSRRERSEAWRRLGECQAMNEKEAQAIRALEEAIKIDENNLEAYMSLAISYTNEGYDTAAHQTLERYISRAYPHLKAAPLAAEISGSKDPIEGTTGNPWASLNRVTDLFLQAAREGNAAGQVDPEVQVGLGVLFYTQSSYEQAQDCFNTALSARPNDFLLWNRLGATLANGGKPEEAIAAYHKALELRPTFTRAIYNLSVSCLNLGAHHEAAEHLLAALSLQQTHTLPDVPDGEQPAPTPLAEAGESHNLWSTLRRIFLVMDRMDLAQKAHVGSELAQFRGEGFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWW3</accession>
    <name>W3VWW3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00319</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWW3"/>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000286">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS65246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="182" mass="20527" checksum="A4F081021E1EFA01" modified="2014-03-19" version="1">MGSSLSKAMGKIFGNKEMRILMLGLDAAGKTTILYKLKLNQSVTTIPTVGFNVETVQYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLVFVVDSQDRDRIDEARQELHRIIGDREMRDCLLLVFANKQDLPGAMSPAEVTEKLGLHRMRDRSWFVHPSCATSGEGLYEGLSWLSQNVSSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWY7</accession>
    <name>W3VWY7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9">U1 snRNP C</shortName>
            <shortName evidence="9">U1-C</shortName>
            <shortName evidence="9">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00352</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWY7"/>
    <dbReference type="HOGENOM" id="CLU_079697_1_0_1"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS65276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="227" mass="23866" checksum="20E97452390075BE" modified="2014-03-19" version="1">MGKHYCDYCDVFLTHDSVSVRKAHNSGRNHLQNVREYYQTLDPEQIQQVIDTLAHEYDRRGIEKPRDLLQPAGSSFMTFGAGPLSGASDRAFGSQGPPRMSMGGSGGGGSNGTGPPRGGYGSGPGGYSRYNGNNAPSRDQGPPPNYNRPPPQGGPYSRPPPNMMGGANAPPGGNGAYPPRGPPPGYGAPPSNMFPSGPPPNMRGPPPSLPPNPSYPPPQSRSTYGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDE5</accession>
    <name>W3VDE5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDE5"/>
    <dbReference type="HOGENOM" id="CLU_024343_0_0_1"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="327"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="723" mass="80799" checksum="5A3B8C5F8412278B" modified="2014-03-19" version="1">MSLPYCLASASRRNARLALCNQAVRRPLGDRCGPILEARCVASSSRSSAQVQDEVKQDRREISKLSPEEDELKLGKRARKAVRARQRKHEERVLREARNTARAEKRAEKARTASAIDNDAGTFTVPRSPILKVRHMLRDEEASPHRSPAQADASQEWRQQARSGDISSPTQGWNGTLFSSHISALLRGFGTLPNTPPVQAVALTGQDALPQREATSTKARNDDASESTSAAPKTSPSSMTKSERMESQARVIFRAIRDARERGMIDEDESFFYPYPEGVPPKDQHGKDTVWLNLGADPEAWGREIPTVKDRWLEVLSLGLAKEITPQSEIRRPMGTEEEADAAEQLASQDPLAFEDLVEDYDLEDHERLEQLGDSIVNMSSRLLAYQSFPDVNEGSLTRLSNYPTQNNFLALLFQECGLAARRDELRDELRGAPEVDAQDAGDGHPNDTAVKMAAKALEGAEEKEQLPSLIKRDADMFEAYAAAVFLSHGNDFNVVHAWLSHLFRPFQDQAYRFMVQRSEALAKLQAARAADANASSSSSFSFLNRGSLTPSATNIAADGLGIKSASVDPSSVSLTALFPDFMRAEKSTSPIPTHVLQGGSEAFITDEFLTVAARARRQREERLREELRLQDQRELMNMGWFRKGFLNLSKGFRQYVMGKDVVREEELRMRERIHQQRGLSEKDRERLRARERSNAGISIKSTGSKTRTKITGIQEHAPFKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDE8</accession>
    <name>W3VDE8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_06491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDE8"/>
    <dbReference type="HOGENOM" id="CLU_023690_0_0_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF14">
        <property type="entry name" value="AQUAPORIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="76693" checksum="580072621EB83047" modified="2014-03-19" version="1">MTLLGDTHGLTVTVPSLPPLVKPHSLLHALRGVPSLTPQSLRISCGRYKRAEPREPTLRMDAVPPAPPPRTGWPDCTSAIGTVEAERLQRLRGFGFASHTAVCFLGGGGGGGRAVSTARARHFFADPTVGRLRQGRTSQATASSEPLSLSLHRQCPPDSARLRSSALSPRLVTAAVLLLHAQTMLASAHLLQDGCWKYYRPVMLMYPAQADAAGYPWLHLHELPRTRRERGVPCSVVLLHPRLDCGHATARTPEQATDLQKDTWHSSLLSALLPRMLACPLPLGFPSCTLVQRSSSPSPPIHTTSILRPSAPRHQSTAMSQPAQTPSYIPAEQLQHDVSDKDAGSNSSHHFQRAHRKNGELELGVTEILEGRTDVQRQVAHSSGLADWSGRVKLEQAMPKLIPALIAEFFGVLFYSLAGEMATAGFLITTYAGTPMGNLTMIGFAYAFGITFAIVVCATTSGGQFHPGFTIAQVVFKGFPIKLAPLYIAAQILGGMAASLIVMGSWHDELMKITHLLEATGKAATIFTAEGPAGAIALFPTPGRSMGSIFVNEFFADVLVAMLVWANLDASNPFTGPQVAPYTIGLGFAMVVWCFSSSNVAANTARDLGARFVCGMFWGDQCFPAGYSALAALTNIPATLVGCGIYTFFLSDTRRPPATVALNHLHEEHVRSVERAETLHAEMLDQKIAQTISRGGDASALQKKRTNLSVKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDQ3</accession>
    <name>W3VDQ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDQ3"/>
    <dbReference type="HOGENOM" id="CLU_023751_2_1_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832974" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45978" checksum="134028BEA50FF016" modified="2014-03-19" version="1">MLYLVLLLLYVSGVLCDAFTAVRGTSGDISHRTVGRTPTGAYARSLNITSTSQLFTWYSQTPANESDAEAAFIIVHGVDRNANTYFRVLNNAWSHARDEGIGSASNNSIRVAPMFFSTVRDRRAYNTSHLAWGDFNAWTAGEPSTHPRGSGVSSFSVLDAMVRRFSNRRAYPRMKWITLVAHGGGAQMLQRYAVLGMPNPAPARLSVRYVIGDPSSQLYFTPDRPVAVDTTSCPAWNDYRYGTRRYSSDYAALSNRNAADLFRTYAAREVRYVVGLNDTRTDEGDQTCMAHAVGGPKRRNRNLAYWKYINLLAGTGADLRNFPGTFPMLEGKDPQPNVPASTSGGARRFRGTQLRHTLSVVEKAGHSASRIYGSVQGRNALFGEQASSGGGDVPDLAQELVGYTADAKGARNDVPDESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDT7</accession>
    <name>W3VDT7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ser thr protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDT7"/>
    <dbReference type="HOGENOM" id="CLU_016583_0_0_1"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="609"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="769"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="874" mass="90194" checksum="EF538BAC606151FA" modified="2014-03-19" version="1">MASTPNNARANAQPSPAHANRPATTTMPSASASGHNNGLRPPSAGVPSRTPSQNTNSSHRSRASAPGSKPPLAAAEPPYVIDGPGGRIACVADVRGNLSLFNQIAADTNAQAIIHTGDFGFYDHASLERISDRTLRHLVQYSTLIEPALRTKLLAADAPRAPAAIAAGPAADKGSASAVMRQHMLQQPGLPLSQFSDLLVGKIKLNVPVFTVWGACEDVAILERFRTGEYQVNNLHVLDEASTKAIEVGGVRLRLFGLGGAVVLHKLFDNGEGAATIAGGQGTMWTTALQIGELVDTAQKTFDPTETRVLITHASPGREGLLAQLALALKADLTISAGLHFRYGVSYNEFSVQHDAENYRNKLQHAKHAFGEIWDTVKTQVDAVIDENQRMLLNNALAVANRVAPTATATGAASEEPAWKNTWNWNLPDAAYGHLVLGIKDGRVSAETKSQGFNFAYRRSGQPMAPVAPTGQATAAAAAPAPAPAAPRATPAAAAIPAAAAAPAAAQRANAAANAASNAGTAAVPTKVNASKPAEASVAAAGASGAATPASKTAAASPASAKPVKEKKERTRERGHESAASRSDFDGGFTSGTDGRKSPSGPRKVRNPFTLYVSQLKEALPVTEDELRTYFGPAAAGITGIKLVFDKPHRRGASSGKEDAEQQRRQRPFAYVEFRDEAAMAAGFKRQGEAIKGDVKPVLEQADSNKASQSQPQQAEAGASGTDKESKRERQASGRKGGETDKEDEAGKSADDKPAGRNSRQRKDKAKAEGGAKAAAAAQAADSAATASADGAAANEPKEPKEPKEVKEAKETKDVAPAAASGAGDKEKKDKKETAPAPAPAPAAAPAPAPAAAAAGGEKKDAPTAPAAASTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDZ6</accession>
    <name>W3VDZ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDZ6"/>
    <dbReference type="HOGENOM" id="CLU_004128_0_0_1"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="7">
        <location>
            <begin position="833"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1081" mass="117752" checksum="87A369DCED7C7957" modified="2014-03-19" version="1">MRAPRLSFSGVGTAPSARASSSSNVVRMAQPRRLSTQPQHPAPTAAYPPELFQDIVHRSLRSMLSPRDVNPGSTTPCWTAQDIDAAPATALQAKTGKARASASPTLNTSMLILRLIRNNRILSAMTAFTEHMNASSLPPFTHDQLEAIIVALRIQSRRHASARPTPKQQAAAVHAELWRPSRLDPSISAKSLPIPVQCMYAMSAVYDVSIEQKHRPTAKMVSAMLATFATTLAPEQLLQAAHTAIQHLFPATITSPRRLGVFWRYISHRALSTFIRVFGRAGVPEEGEEFLRQWTRAQRAAAPQQPDAAMLQADITLDLAGWGSNIVVWQSLINARVDAGHLAEARKWLDRYRHATKQLSAAATGDDAAKALPIRPEPYLAYMAGVRNSARNLRSVGHIRRVLSSTHDVVRLMAADHVPIESSVLAFVLDCDARLGHVDGGASLLHELGDLIHTMALADPALLRSLLHMRRAVVSNTSSGGARSHLSNLPSTRSLIRSLVRVGEGETPASRDHIAECRSRGMLNDALITVMAERDYPAAVAVLNLFERWMITVSQTTYSIVLTSLIAHGHHDALRGEAAQATRSDSVYSLEATLQSMAREGNGEQAHTIRRALGDQVLHSDTFLASAQPATPLRKTQYLVRILNRVCAAEIEAVESQEQLPAWAARVTAMQTQHWKDDVRSVVAKAITGAQTGLLGHKDARKQRIAGPAKAPLLFAAAPRLSPKRKHLTAAPATWSRELSTSAAARQTAAPSCDLAASAKGDYTHLEPVRTVYIPGFVPYDLGLALQEHLVQERAQARQALRALDDASSTSASVRAGLTLVSASASEAALRAQAAQDTLLLLQHRPVYTEGRREESENFDVAEALRALGADYKLTKRGGQITYHGPGQLVGYPILNLGAMGLASRCYVDRVQDSLISLLATRGIGTVDPPDAHTGVWADEYHKIASIGIQVRHRVSSHGFALNVEQRAMRGFRHIVACGIVGKSMTCVHDRLDPTGPFARYNSGQQGDKDESVESVASDYVRHFANVFKRTTRQATQEEMSFELAPEDKAAVMRQRLGIHVAHDEQVVQAIRVGHHRVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE25</accession>
    <name>W3VE25_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE25"/>
    <dbReference type="HOGENOM" id="CLU_017002_3_0_1"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="64534" checksum="6AFBCCC7DEBDEA37" modified="2014-03-19" version="1">MTSWWRRTSRYISSHSNFFVVTGGLVGGAYLLSQYAISKFQQIQEKLVNDKNAKENLRRRFAQNQEDCTFTVLALLPTLGDQLFAKHDVEQLTESLRSQAAPPAPSTITSDAPQPLAAEPAPPAPIAASASDQQDPQPPQTAEHPASEPQSTTHTLPQPDAPSPQLNPLAKTFVPGGAPAPAQTTQPSVDTAQANGSEAAPDAPVVPEAAQQLPTPQSSDEQPTGSPQTTTDTSAEQLAQTQLSPTVSAVPPPSSEQSQVDAQQQRSKIIADRHAKLRLWNDLKLTSFTRAITSLYCVVLLTLQTHIQLNLIGRFAYLASVEALARESDDPSVLASASHLDSSRVLDHDTERLYLTFSWWFLHRGWNALSDRVADAIARTFSPLSVKAQLSLTDLKALVNDARFIIEHEPSSNATNTNTTDQPAWKRSHFLDVLFPNSTEDEADVLVGAGALDGDAAVYALATNDKLRALLDETKDIIESQDFGTILSLCFDRVFETFFDSLCPTFGVQKSGRIDSTIQVEPLSALESRFQEITDEMQHGKRVRLASLFPLVSRQSQMAIRGVPNEYIEVLADAKELRAFSAVLYAAWSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEB9</accession>
    <name>W3VEB9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_06169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEB9"/>
    <dbReference type="HOGENOM" id="CLU_1086337_0_0_1"/>
    <dbReference type="OrthoDB" id="2556634at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS59855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="256" mass="27059" checksum="5B59A4A2FFF105C8" modified="2014-03-19" version="1">MTVTLESNGAPSGASITNHILTIPHAQFTHFLTQVIHLRSASSSSLFVHCTSVSPLHARTLLAGHAQESAVSGVLGADFALAMVPPNAQPLATSVSSTLPAASAGMSAAWSKRIARRLQVPQLLLSLDLPQQLLATTGQVQAPQDSHALLALERALRDACASALTSAATSTHYAGGGMRYQLFTPPRGGCPAHAHMRWAQPTVSETCSRLTLPHSAANTNRGRASIWHWRAQVGVVPARQIHLHTERWSCAPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEF7</accession>
    <name>W3VEF7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEF7"/>
    <dbReference type="HOGENOM" id="CLU_1807034_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="143" mass="16076" checksum="4C7C618C171BC851" modified="2014-03-19" version="1">MGRMPTWPGFRSALTLDRHASSPRQACGFDFQGPLAQRASAVRCRSPAGARRRARVPRAEPCLLHFRFMPPARGPCFRFVVRVQSSAARIQFGPAMLEWPAFSSSCKDPAARSRSTPPARFEDRPRQKKRELTAVETPPTPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VER9</accession>
    <name>W3VER9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004905_0_1_1"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1097"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1122"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1414" mass="154022" checksum="AAE9E5A944D1DA14" modified="2014-03-19" version="1">MSGIGAVPASRFTRPLPHTPLNHFLRQTKGLLASGALDNEDAVYVVTPRTPSFDQAVAAIAFAFLQQQLDQSAHTQRRYVPVISAARKTCLDDELPELALALQAALVAAENVVFEDDEEYRTVNAYASKKRVVLVGGAAEIKGKEAWNEWLELHGAQLFGVIDTDNTLPTDIHDEKGGVNERLNVALFPPQAVRGSGEAEPSLASLVALWAKQQLANASRADEEVLTRELADLLLAAVLLETDNLAESKTNSADLGAVGWLNPRSSFQLQNQDDATVAPEAQEESGLNDDEANTPNFDAYVPTFPDLDALYRALRAASRTPVKLAGLAPAAAAAMDDGATPDHYEWNLITNTLANLDEAQKAAVPSMVQQTIKGDFAAVLTSAVGTKLLRPIGDKLGQALSSGAGSLDLAALQKDVDQAVGEVVSAGADGFEALCVAISALHAFVQINWTGPELPQSLEPLALLRSTAPDAFPPRPLDADAEEKANKAAEGLLHRASLEALAFKGEPAYHLCRVPVFLVLAKLLIEALFVSADMETVAWWRLRAYTVHSHVLDEPVAFGKKVFEPVNKLRDVLAARAAATKPATGEAKSKWAALSARLILERGVALQRIGSDREAAETFVEAARQNGLVYRMSGALGKRTKFQKEDKTQLILLAKSVVADGGKEDEEADAQAMTGERQEGEKEEPLETGFAAKANPEDQVAGMPSTFALNDDTLLEQTKFTTTTAYAAGSDELGFLDPNAQPALAVLDQCTLLALCLNIRNTQAAHGLTANQMGIFIARVVSHARNWTVHTMSLLLRARLESTRTRTVERSVLQLQALIDQMPTNDSSLQERLKFFHALDLPPKWEMQAELARRYASIGVTRSALEIFERVEMWEEVVQCLGMLGRQQEGVDVVRALLDGTKVEADVEVSARRRQAVGAKSEAQAVMFTRLDRAREAKLWCLLGDLEPDAALAHYSQAWRVSASSSARAARSLAGVHFTQQDFAQAAKWLKLALKINPLYTRSWFILGCCYMRLEKWKEGAQCFRRCTALDDEDMESWNNLASCYLRMVEGAAAASEAVDIERMGMQGGLPDILEAEEEAERVWDAGARSDDDEGLSEWSGSSRSDSGVEVSSESEAESEAGTEVGTETGTETGLRDPGEPGAARARRANATTAYSLKLLAHRSLQQSLRFAHDNWRVWFNYMIVCIDVGYLLEATRAMQRVVEIQTRSKTSDAERAKTVDLAVLSRLVDAVTRLPKAELEAEMVAATEVYEAATAQYRADSGVAAPVQPKLDVNSGLGLYAPVRRLFDETLLATISTSAGIWKLYARLLTWNGERTRAVQHALLNSYTAAFDQAVAGDLASDKQTFVGVLHDLRNLVDALLELADNETGDPDAPKPRFQARSLVRTFLAKTRDAWDAEPEYDEAKQLLEELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF28</accession>
    <name>W3VF28_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF28"/>
    <dbReference type="HOGENOM" id="CLU_013093_3_0_1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="337"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="558" mass="58855" checksum="61E4DCB1978DCBEC" modified="2014-03-19" version="1">MLASAPSSSDAKSLRSNVRARQSSGASVQPTPGMGFNTYNQVSCSPTEASSHKTMDIMASQGYIAAGYGMFGIDCGWVAKSSSRDSAGNLMIDTNNFPSGMKSLGAYATSKGLEFGLYSDGGFLACDPDVPSKRLGSLNHEAQDAALLKSFNVSYLKYDNCYAGGSTAGDNAPKAARTDFPTRFGAMSNALAKVGIHKMLVCQWGVPQRQSDGSLVGPDQWTKGLSTSYRLSDDIAQGWVNVVRILNQAIPISLNGRSGPGHFADGDLLEVGNAGMSIDEQATHFAFWAMIKSPLMISTDLSTISSEAKAILLNKGLIAVNQDKLGQPVKLVERRTNDFDLHAGNLSNGDLAVLAIDWTNSQRTIKIDFAQLGVQSADVMDLWSGTTQTNVQGSFSKKVNGHGSVALRLANVKALSSTAPRLTYVEAESGTLAGNAAKASCAGCSNGSKVSNVGGGPGNTLTLTNIKPSSSEAVLYFDYINADVGFSFVGATNERFAQISVNGGTAQNVSFPLSGYDWNKDVTKAYKVRLSGFKPASVNTITISNPNGYAPDFDRVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF58</accession>
    <name>W3VF58_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="16">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_05801</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="16"/>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF58"/>
    <dbReference type="HOGENOM" id="CLU_014329_1_1_1"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000005">
        <property type="entry name" value="crossover junction endonuclease MUS81 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832912" description="Crossover junction endonuclease MUS81" evidence="18">
        <location>
            <begin position="29"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="ERCC4" evidence="19">
        <location>
            <begin position="316"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS60253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="611" mass="66469" checksum="78057AE7F67D41AA" modified="2014-03-19" version="1">MNTETESTAGGNSLWLTFLAAWIEEAQAKGSKVAQTYRRAHQSLASCPIEFQHPCQTTQLVGIGPTIANKLEQDLQRWCSENGKPVPERPSRAGSTSKRISGPAEAQGGDTEEPTEGASAATAKRRTTAATDRPTKKRAYVPQHRSGAYGLLVGLHILTRSSTSSSTPNVSKTQLINAARPYSDTEYESGASSSRSSAAVPLSSHAAAAGGSGGSRSFYTGWTSIKTLIAKGYVLQSGNPARYSLSDEGAMVSETLARDAGLGDSIAQPADVDRRQAEEVSDLDDDWSDDEQEAALQTRVSNFEPEILTAGSYSIHLLVDNRERHRPGRRQEREPIATLLLERGVDVETRALEVGDAVWIARRKERKGGEEDEVVLDHIVERKRLDDLTSSILDGRWRDQKFRLSSSGVAKVLYLIEDHDVENQMRKFGPQIQTALSSSQVVDGFFVERTSGLTASIDYLAAMDGMIRRIYEHRDLSVMPSALISRSSFLSTRDELQSKSPSASMLTSFEAFQALNSKSGGLTSKEIFGKMLLCVKGMSAEKVREVLAVYSTMRELTDALAEAHDEPGGADAMLSSCTDGLDPRKKIGQALSRKLSELFLQPRYVPESGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF78</accession>
    <name>W3VF78_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Monocarboxylate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF78"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56248" checksum="57FBF55529AF3D4B" modified="2014-03-19" version="1">MEHLELVAHAKEFDESLHHHQEEAAHVSHDNAANHATTSAEKPPRAAHDVDKQEPANTAAPHPIDAATTSIDPDNAPAKDRGWAAWRFVLASATMEFMVWGASYGYGSFQDYHQHNDASPFHTASLTSTSSIGTTLLAGQHFIPLVAFGLYSMFPSLIKTFTYTCVVASALSLLIASFAQSVALLIVFQGLLLGIFGGNLFTTTILWLPNWFDKRRGFATALIFAGSAVGGILWPILFTQMLERIGFRWTLRAWALMQLVVTGGAVSCLQPGCRLESTQRPIRWKRIVPGFPRSLLSPLTLLNAGVILTQTTAWYSVSLNISNYATAMGFSSATSTGVLSAFNASAAVTYFVLGYLVDRFPYPLIMATSTTLNLVFTVLVFGFAGGSLTKIIVYVVFFGISGGGFSSFLTPMSREIKDKAQSDEFSLRFLYLVCIRGLAAMCGPIIAVQFYPDQLSKPSAYGSFGFTPFIAFISATLAISTLASLVVFVYKRYNQPRLQRRKASLPVTPPPEPSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFD4</accession>
    <name>W3VFD4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05559</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFD4"/>
    <dbReference type="HOGENOM" id="CLU_023861_4_1_1"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="311"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="483" mass="51920" checksum="684D75C06420F403" modified="2014-03-19" version="1">MVAALRTARALRRPLGHVRTISSSHHAAAEKRYYPPPEPFVGGESVSIQPSPFSTFGASPDLLTHYLSLQPAPLTLRQLMAQGGKPGQALTPEQLLSSAQHTHRELPIRLARRVGGFRALPFIVGSNPFISRIARLYASSFETLVKFGPIHTQDDNSRFTAVIEDLVAAHAQNIPTLARGFQESRKYMDARQISAFLDAAIHSRIAIRMIAEQHLALSATSNDLRHLAPKTTNNIAQSPHSPDPDLPPEGTSSQVHHEYGSPTAVGIIETQLSPARMTRMCAAFVRDLCEGTLGAAPQLILEGDLDVTYTGVPVHLEYVMTELLKNSYRATTENFFKHSGSSSTADMPPVIVTIAQSANHVSLRIRDQGGGISPQNLPHVFSYAFTTAGTSAELEDAEESGGGPYAMQAVGGTGGDALAEMGKMGLASGLGTLAGLGYGLPMARIYAEYWKNGSALDLVSLYGHGCDTFVKLPRHIELSNTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFH8</accession>
    <name>W3VFH8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFH8"/>
    <dbReference type="HOGENOM" id="CLU_269171_0_0_1"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038889">
        <property type="entry name" value="Shugoshin1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21577">
        <property type="entry name" value="SHUGOSHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21577:SF3">
        <property type="entry name" value="SHUGOSHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin C-terminal" evidence="11">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="278"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="393"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="609"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="948"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1056"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1138"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1193" mass="124887" checksum="A3B10BF9499CFA13" modified="2014-03-19" version="1">MPPSTRREVRLSASLPDNMAHVGGTQPSDQSRSANLFMPNIESILENFELFKRKHISQNREIIKANAVHQLRIRELENRIQTLEAEKAEARLHTVGLEATVSHLHHAMASIYAGWHLIGKGFANSTSDPASIPSFHFDAQPLSWPPSNRIKLEPNPNTAAVVKQVATAPGGHVGRLEEELLQGPTEDAVTAESNSNHKAWQHSVGALQSARHPTVDASIIDIGGAPSPMGSPQLPDELEDAIAAAAERTMSQAWSNRGGAATPVPKPLSLNMFFSAPQDSESIDNSNRQALRRSGRKSSRRQSGFIASQPEHDPQGNASDFPHHERESSPPPTSDPHDDQYLPSEANSEAMDGILAYNGQEATLINRPSAFQHPPTPFLDITNHTAGTSYLDAASAQHTGREPVPAQEPSSKPSTTDTPYAWPREEPAAASSSSEARTPGGRKRKVPTHELPEPLPTPMRLFGTAASSDATPMATAPVDSESDPATGRTRRVRKSINYALPKLNTKMRKPDPSDLIPATTPHRSNRSTPSSARGMIGSSGNLSDIRKLHEEAALHQSPAERTSNLRLTGSPRASTSRAKLLAAQPLTAQEDAGGRMADLFEIRQQAKMLADQSNASHPASGRPHAFWDNVTDTSDDESRATSNADLGELAELEAAMGELSTVDEAHQADTPRAPQSSAWPSRSTVQMSASSSTDSMVSGSSGGNLAQRPSLRRKTTTLPSRSRQSSVEQALPSDNVLATRPGPESATTNASANTARAKVEGDEKSASPKELDLDRKEQAQGIAKNSNPGEVKRATRQPPAVTSSDTSSVELGKGRPPPAAAAGSLVAGMKPKQRPASAGALLSSRSVSASASVDSSSERPRTFSGATAANAGMAQSQSSAGPSGCTPRSAVSTAQHRASLHSALTSQSKTGASQVTPRIGAKGLPPTSTPTFRESPRMTSTPMLRPTPSASSLASESSGRSSPALSVTSSTSAGTQLSSSTRTSMKTSTTATSSGNAARRPGTAGSLSRDDTTPKVGTQSTTMPGARPQPARSMPSLRRGSDKAGVTSTPRITVRSTSSTAASSGVGANGTLAASSAATIAASRVARAMSSGMPVRTKEAAAAPMGLGIDFSSVVDEVSAGKELLSLTGEIEQVVQLASSPLRASSSPSSRSSAAPSSSPRSTYKASHDDGPTLGGSQAKTRRTSRRISSMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFT6</accession>
    <name>W3VFT6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFT6"/>
    <dbReference type="HOGENOM" id="CLU_066780_0_1_1"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30255" checksum="92DA95BDF1883C1D" modified="2014-03-19" version="1">MPLLLLRQAAASSSSSSGQSRIDPTKDQRTTIIVACVYAVAIIILWNIPILNYILYPFKLLTVGFHEFSHAAVGLCTGARIESITLEPNEGGATRMRGGIPWLTLPAGYLGSSVIGAALIACGFDERASKVASIVVGVFFLFTLWWARRDWLTWVLILAMIGLFVLFWLVASSVALRYFVLFIGVMNCLYSVWDICDDLIFRKVNESDASAFSKVVGGPPQFWGVIWLLISIAFFGAGIVVGILAFKTPVAQQQADNFLDVNLRRRFFLGYSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG17</accession>
    <name>W3VG17_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG17"/>
    <dbReference type="HOGENOM" id="CLU_023643_3_1_1"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="287" mass="30917" checksum="AD0DBAA570AEBB64" modified="2014-03-19" version="1">MLVADDAMGAAAESFRQALQQARHPIALAGAGLSAASGIPTFRGAGATPEAFKRDPSKVWQFYHYRRSVVLAASPNAAHKTLAKLMMQSPLREQLLPNAQSFHLVTQNVDGLSGRALQELAPSEQSFPSATAGSILEMHGNLFKTICTSCGDSRIDLRDPLCPALRGAEDLSGEYRAIPTEHLPRCSRSGCNGLLRPGVVWFGESIPELDRIQPLISRCDLILVLGTSSTVYPAAGLAQIVKHSNHGQVAVFNIEEPSDNERDDVDWHFVGPVETLLPQILSVTSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG58</accession>
    <name>W3VG58_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Isovaleryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_05349</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG58"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_1"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000007">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="15">
        <location>
            <begin position="45"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="14">
        <location>
            <begin position="163"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="13">
        <location>
            <begin position="269"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="376"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="403"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="405"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS60505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="45558" checksum="2BD3C46B3E88F303" modified="2014-03-19" version="1">MSFSALRAVAAPLRRTALASSSLRSGVARRGMATTFYNTDVAGLSEEQAELRDAVASFVSAELPPEKAAAIDRNNESPKDIWTKLGDMGLLGITVPEEFGGLGKGYLDHTIVMEELSRASGSVALSYGAHSNLCVNQLNRHGTKEQKAKYLPDLISGKKVGSLAMSEPGSGSDVVSMTTTAVKKGDHYVLNGGKMWITNAPIASTFIVYAKTEPKAGSKGITAFILERGMKGFTQLPKLDKVGMRGSDTCEIHFDNVEVPETNVLGTVNRGAAVLMSGLDLERLVLSGGPLGLMQAAFDYAVTYAHERKQFGTRIAEFQLIQGKIADMYTKLGAARSYVYAVGRACDQGAISRRDCAGAILYSSDRCVEVTTEAMQMLGGNGYTNDYPVARFWRDARLYTVGAGTQEIRRMLIARMFNEQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGK2</accession>
    <name>W3VGK2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_05904</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGK2"/>
    <dbReference type="HOGENOM" id="CLU_014026_0_0_1"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="777"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="493"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS59927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="811" mass="88839" checksum="FD8E7A73569C751C" modified="2014-03-19" version="1">MTHKLNLIPSNQKVLAISSTTSVMAGTGRGSPGPGLALWLAIWALILTTSVRASFLGTLLFGKDTLEPVREAIRQTEHMRSQVYGWYHDNATEAANFSVTPDPAELYTLLPATYSGRSLVAPDGAYYRDIEGYYKGSWSGWDMSTVANRSLAIDSRLNRTVAERLATNAPPQYLDGVEREKLVQDRGAFDWLTMDPGHMDLHLQEEHLLKGNVSLVTGSLSFSVPKSEKSVDFSLEGLHYIPTGSIFLHAMSDEAVNGTDVRTVLGMVPRANNATANATVAAIDKAFQLRIDMLERIIASGSYDPPEASSTGVVATHNCSLHVYAQLRSAGAYDEVQGSINALEREMAVSTGISTIAPPALQLSMLAYSPECRFVASAKEVTGLLQSRVWKKAVRYALMYMVVVLVQTWLLVQQMEATTTPSGLGKLSDKTFLAQSVLDAYSCLIHLSVGVALDNETTVPLIACSFMSGMCFMAFGYRYTITIFRTHMDAAPTPAPTPAPAPAPAPATAPGSEGQPMPVDAAGATATPPQSAGVETPEERTARRRGRAIFAAGFFLMMVAFFPLVTVAILLPFVYSFWIPQIWRNVQRGTRKAILTRCVVGTTMARLFVPLYVLLCPANVLMAEPSAWGYVLGAYVVVQMLVLLGQDVLGPHFFLRAAWVPEHAAAGWEYHPAVAGVDAEQEQGAEYGDCAICLAEIEDTAKPTRRRGGVATRWWTLGRRDGSYGYDRVDEAEEFEVDEERTTRRYEEKQESGWAWMARLKPDVGAPGALRRRRMDVMVAPCQHAFHTECLERWLTIKNECPSCRSMLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGL9</accession>
    <name>W3VGL9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_04572</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGL9"/>
    <dbReference type="HOGENOM" id="CLU_000288_59_3_1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="51"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="321"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="464"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="646"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS60675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="814" mass="88882" checksum="CB66BB7A47120AFD" modified="2014-03-19" version="1">MSSRQPSENREGRRASGAGGASSSRSSSRVASRSGSVHRSKDKKPVCIGQYIIQQTLGAGSFGKVKLATHALTGHRVAMKIINRRKISSLDMGGRVKREIQYLKLLRHPHIIKLYEVITTPNDIIMVIEYAGGELFQYIVDRGRMPEPEARRFFQQVICAMEYCHRHKIVHRDLKPENLLLDEYLNVKIGDFGLSNIMTDGDFLKTSCGSPNYAAPEVISGRLYAGPEIDIWSCGVILYVMLCGRLPFDDEYIPTLFKKINNGIYTLPSYLSQDARHLLSQMLIVDPVKRITIHEIRQHPWFNVDLPAYLRPLPPTPAAENRGFNFGLTESPRETGSPTDIASSAASSSAANSGASSSQTSASASRTGSQPAVLDDLGPIDAEIVDELVGKMVGFNRDELLHHLADKSDNQVKVAYQLVRDHRRMLQIHHMEDAHGMENFLAQSPPAWNEGLEGFMGRSTSIKRKNRDKEVAGGAAPVPPLPASAHATATAADDEEGDSFAVDAAEVDPSDDGNETLASDDDDLLTDEDGQLTDAEDAAGERMVRIAVLETSLPGYLRAREAERLATPSADKTAWPQCTPLSPTSGSGTPALPAAAAASAAQMHKKPRSRWHFGIRSRSPPMEIMLELYRTLQSLGMEWRQKPVARAAKAAHEGEGEGEGDAADKEKHAASGSESAAGKGEELFFLETRWKVGHVVVRMDLQLYHVDAVNYLVDFRNVGYTMLQPEATAGTETTDADADTDGEVAKLEAAFERAMSETQQAMRDGEPPAQHRFDGTRIKPSLAPAVPAGRKEVNSPFLFLECATRLIVELAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGP6</accession>
    <name>W3VGP6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGP6"/>
    <dbReference type="HOGENOM" id="CLU_017516_0_1_1"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="654" mass="71583" checksum="5070549479250C82" modified="2014-03-19" version="1">MAPLPNAQQASQQAARAADRAQVTANNTANKLSKWVEENRTLVIALATGTLALGGYYLYSRSSSKAKAKGTASDSDDEEKAGSAGGAASASASKKKKKKGTKKKAGPAAGGSSSTDASAQRSDGLPSDPSGPLLDEATDDQLAELPESEILKLPQEKREKLSQHLKTLGNKAYANRQFEKAIAHYTKAIAAHPMAVFYSNRAACYSNLGKPEQVVADCDEALKMDKVYVKALNRRAVAKEQLGNPTEGQDGVGEDKAKLLFDSLADFTAVAILGQFKDQTATESVERVLRKLATGKAQDILKSREPKLPSPTFVTAYLEAFRAKAKPELPEQPSQGDETLLKAYGALEAKSYPHAFTLFNEAIEQGLSNEDLEANAYNMRGTFKFVIGNAKEALADLERSTTLRPKYVQSWVKKASVHMELSDKEAAFKDFDRAIEADAEDPDIYYHRGQVNFILGEFDAAIKDYEKSTSLDDTFIFSQVQYAVAHYKNGNIGHSTAAFRKLLRNFDTSSEAYNYYGELLLDQQKFEEAMEKFDKAIEIEGAKQGSTNVLPMINKALALFQWKQDITAAEELCRQALDKDEDCDVAVATLAQLSLQQGKIQDAIEYFERSAKIARTEPELINALTYENASRAQLKFIQEFPEQGAALGQMAGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH21</accession>
    <name>W3VH21_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH21"/>
    <dbReference type="HOGENOM" id="CLU_053595_0_1_1"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000044">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="344" mass="36399" checksum="A472021A18458338" modified="2014-03-19" version="1">MSELTSACFLFRPTKLDERGEGKRCTSRLGRASDVRLRRTTSTGNHNDSLFHPKTITSSNSYRIIKMSTVTQESLAAGIESLLSSLPSSLETLPAIEPAPAVPTTEAEVASLIDHTLLAPNATLDQIEAICAEAKQYRTATVCVNSSMIPFVAKQLAGTSVLPISVIGFPFGSANTASKVLEAQTACAEGAREIDMVNNIGLLRCKRYLEVYTDVEAVAKECHTHGAKLKVILETAMLTKPEIVAASYIACLAGGDFIKTSTGYGGAGATKEDVRLMYEVAKTQGLGWNPSDKEVKASGGIRSLETVHTMVKNGATRVGASGTKAIVEQIRNGAAAPPTSASAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH98</accession>
    <name>W3VH98_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH98"/>
    <dbReference type="HOGENOM" id="CLU_2373670_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="95" mass="10015" checksum="4680A8EA22528EDD" modified="2014-03-19" version="1">MGNTSRTLTLTRHAATQKFPAPDPSSSSPLRTIADSDVGRMAHSLACSVFLTSTQVAWTAAMTISTPSELGRDVMAASSQMRGSLFVLRSGRASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHE5</accession>
    <name>W3VHE5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_05754</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHE5"/>
    <dbReference type="HOGENOM" id="CLU_000288_26_4_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000007">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="579"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="155"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="407"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS60212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="853" mass="89879" checksum="9751842A2C2C12F6" modified="2014-03-19" version="1">MHQSPKRSVIKHPHDFHGAQVMPRTADALAEATSRPPMPPSVAHTDPSSSTTPNYLKGVEGIGNPDATFSGLGSSFDFGDLNLVPKRSAPAPPSHPNSTAASGSVFASRQAGPSSTSASPTSTSASTFANGTSSAAWSAGASAAAAAGPYRPNPTINTSVQAMQGPRSGLPAQSSLPFGVGGHPPAASPVSGPVSASPYSSNAPGASTSNAPFPPRPVRSNTSGPDTFHTVSSVTASQHVAPVMAQRSHSSIGPQQHQMIGSPTLNQSSPTLEHGAPGESTPSLTTQSQFVHGSRDRERSRDGSATPGGRNTFKSVFGGFVNSMSDVFSAQKKIEISTPYDPVHLTHVGFNSDTGEFTGLPKEWQQLLQESGISRQDQEANPQAVMDIVAFYQDATKSDGDTDVWKKMGYAKGNNQAPGTPRTDTSSSDDGFKSGPQPVLYEKPRAAPVPPGALHAKRPGDIGSPDLRAPHATGDVALKPSRPAPAPGAGQATKAGSPPIGSRQPGASGASVSRTGTTNGTSTSSATAKNAKAAAAAAPAQGPGAVPRRRETKKNVVKDSDVIAKLQAICTDADPTKLYRSLSKIGQGASGGVFTAYQVGTNHSVAIKQMNLEQQPKKDLIINEILVMKESRHRNIVNFIDSFLFKGDLWVVMEYMEGGSLTDVVTCNIMTEGQIAAVSREVLEGLRHLHEHGVIHRDIKSDNVLLSLQGDIKLTDFGFCAQIGESQAKRTTMVGTPYWMAPEVVTRKEYGPKVDIWSLGIMCIEMVEGEPPYLNENPLRALYLIATNGTPKINNPENLSNTFKDFLKTCLDVDADRRPDAVGMLAHPFLKRSESLRTLAPLIKAAREQTRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHU8</accession>
    <name>W3VHU8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_05832</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHU8"/>
    <dbReference type="HOGENOM" id="CLU_009281_2_2_1"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="177"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="436"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="681" mass="74261" checksum="AD9FF794AC12B159" modified="2014-03-19" version="1">MHGSQRSKSEPQFGDTVREPGTLPVPTATQLHRELQRSLQTGAGHGSGALVAWPSRPSAVGQCIRLARLFALSLPSRTNILPEAHGALSSSPTPRPDTVRAESEQLDRLDQARLGLASFSKPAAQSLPTITCITADPSLFACNLVVRTQRCPTIYNPPTPSYPRRSKQVDTMPELVGSVDAGTTSVRFMVFDEFAKVIASHQMEFNQYYPHPGWHEQDAHEIIDCVHECIDKTIAKLEKEGKYSASDVKVIGVTNQRETTVVWDKDSGKALTRAIAWPDARTTHTIRELSAKSDKGVDALKEETGLPLSTYFASVKLRWMLDNLPEVRKAHDDKQMLFGTIDSWIVYNLTDRKVHITDASNASRTMFMDLRAQKWDKKLCDFFGIDMDILPDIKSSSEVYGTISKGALEGVQIAGIVGDQMAALVGNKCFQPGEAKNTYGTGAFLLYNTGDKVVSSKNGLLSTIAYKAGPDAPVYYALEGSIAVAGSAVKWVRDSLGLIKEAHEIGELAGQVDTTGGVYFVTAFNGLFCPYWDDTAAGTVVGITAYTDKRHFCRATLESTCYQTKAILDAMAKDSGVALKALQVDGGLTNSDVAMQIQADILGINVERPEMRESTALGSALLAGSAIGLFGWDINKPETLSKVNTAGKQVFEPKIDDKKRSELLHGWERAVERAKGWNENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHU9</accession>
    <name>W3VHU9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05574</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHU9"/>
    <dbReference type="HOGENOM" id="CLU_040684_0_1_1"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="323" mass="36025" checksum="D4C3229ED00700A8" modified="2014-03-19" version="1">MPSPVRASTSIRRLSQTARQLSNSLHTMASAQDYKTRAVGSPNTLDYRVFLENTKTGLPASPFHDVPLFADESKTVLNMIVEIPRWTNAKVEISKEENFNAFKQDTKKGKLRFVRNCFPHKGYIWNYGAFPQTWEDPHHTHPDTKAKGDNDPLDVCEIGEQVGYTGQIKQVKVLGVMALLDEGETDWKVIVIDINDPLAPKLNDIEDVERHLPGLIRATNEWFRIYKIPDGKPENQFAFSGEAKNRKYATEIVHECNEAWKRLISGQADAGEISLTNSSVQGSKGFVGANDAAVTSVPKANPQPPAPIDASIDKWFFISSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI78</accession>
    <name>W3VI78_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI78"/>
    <dbReference type="HOGENOM" id="CLU_1475756_0_0_1"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833194" description="DUF1748-domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20006" checksum="02511497E5843559" modified="2014-03-19" version="1">MFGRIFHLLFDAMLVSVALSGIKRSTGLTPAVSRMPNKDLRNLMRIYLEAGEWIMDFSVVILGRSSSFERKWQAGPDDGGGVPVHSHDIGFAFEACVADSMLPWTGQRKRASGMCAAHGQKSVHIGLKPAERSAVNPKEGVKERGTAIRLPDDTGTDRHASQEPQGGRLLHVLGCPGQFDRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIH9</accession>
    <name>W3VIH9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIH9"/>
    <dbReference type="HOGENOM" id="CLU_018687_4_2_1"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="476"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="770" mass="84332" checksum="86D6D7A97BC5E2AD" modified="2014-03-19" version="1">MVHGRVVLEVDLLLPRLVGSFRLDAPFDLLALTLTIVRSPHRQHHHRCQSNGHRLAVSAPSQHGDRHGLGCPSAQQCCWHPIRATSPMHSSTRSAAAATRRSNGDFDDQAWGIESDDEDFVTQIAPRTNVPRSLKSSSRSSSYSNTNQPLPLPHSTHNHHKASQPPHASSESHGAAAAASSSTAPIALTNRRTSWTVVDRQKSSHSTTTTTTTNDPIVGSPPTDLSDAVAAGLDLDRANDHSGESASGSDRGSPSGFHLVGHDDPKASGSETEHVDLNTGRTVRRPSGAARKPSSGSTEAEVLRRSLRSDMDQLVRDPAHALTRLSAQWASSHQPSSPSSDQPSDPAQTLTTTSRLGVAPTPTAHEFSFDPIAAAGDGLIMTGPSFVDAGAANRGISNSSSYASNITNADVSVDSDSTAAANTASTSSAAKGDTDRSSSLSRKRSVRSSRRRQQLLNCLSKQSVDMSQLRTLAWAGVPEELRPMVWQLLLGYLPAVASVRTSTLSRKRAEYVAGVELAFAKGIAALDQAIWHQIHIDVPRTNPGIRLWQRQATQRALERILYVWAIRHPASGYVQGINDLATPFFEVFLSAYIDSDPEMFDVALLPQKVLEAIEADTFWCLSKLLDGIQDNYIFAQPGIQRQVRRLGELVARIDAPLHAHLHDQGVEYMQFAFRWMNCLLMREMSVRNIIRMWDTYLAEGPDAFSDFHLYVCSVFLHKWTDKLRTMDFQGIIMFLQSLPTQSWSDKDAEMLLSEAFMYKTLFGNTAHLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIK5</accession>
    <name>W3VIK5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000026">
        <property type="protein sequence ID" value="ETS60642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIK5"/>
    <dbReference type="HOGENOM" id="CLU_046574_1_0_1"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="368" mass="41367" checksum="BA6911DC43A88ACF" modified="2014-03-19" version="1">MASVITVHRLPVPTGSRVDFGAQLCNADLENVSAADFDVIRDALYTHQLVIFKDQARLSPKAQYQLTRLFDPKSDMYGHGEVVGAKSVLHPDLKTIPHQPQVQVIGNGPVASFEGLEEIQLKHPHHRTFHRHPIPEREDRIATRFYRWHIDAALYGLDPPKVTTLLAVKVPKTERQLLRYDDGSGDVLSVPRGSTVFASSYRMYDLLSEDDKKFVRGTKVSYAPHPYTWMADAKSRSDGLGLVSEGLELDRSTLPEVDDREIKIYPMCWKNPKTGKLALQVHPSAVQELHLEDGSVIDDLEQVRNIVHRLQRPGIAPDLVYAVDWDEGDLALFNNHGVLHSVTGSFLPEEVRIFRQCNLAASEPPLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIP0</accession>
    <name>W3VIP0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIP0"/>
    <dbReference type="HOGENOM" id="CLU_052828_1_0_1"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="270" mass="29763" checksum="E82148F90FDA0068" modified="2014-03-19" version="1">MAPSQSDSEPSAALAEHCYYCFTVIEHELNSNSYSSRPPAAPFEDDGNEYPLFVTWNIFTHSSTARRSILSSASSTATPRLRGCIGTFEPYPLPQGLAEYASIAAFKDRRFSPISSSELARLECGVSLLTHFEDCDDYLDWDVGVHGIYIHLPNPALAPKPLLARGNEDSASSSSGSGASTPAPPRSTRSSRFSRSALGGPQFLTATYLPDVIPDQGWTKQDAIDSAIRKAGFNGRITDDIRNALRVRRYRSQKVSRTYDEYLAWKQDHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIR5</accession>
    <name>W3VIR5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCKDHA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIR5"/>
    <dbReference type="HOGENOM" id="CLU_029393_1_2_1"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000055">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="3">
        <location>
            <begin position="122"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="481" mass="53036" checksum="E2449FB8BD911606" modified="2014-03-19" version="1">MVASTTSRAARQLRFGRQVCHAVRTPSASGSTMLTRTFASTALTRKDGDEPQGHLPGHPSSVFLTSLNDSFFDRVKPKQLSGNSNAQGGIPTFRLMDGVGRLLPGVTDEMVDITEQEAVKMYRTMLLLPQIDVILYNAQRQGRISFMMTSYGEEGAVIGSAAGLDTKDEVFAQYRESGVLLWREFSIDHYMSQVFGAEDDLCGGRQMPIHFGSTQHHFHTISSPLATQIPQAAGAGYALKRTKGRENNVVVCYFGEGAASEGDFHAGMNLASTTKSPVIFFVRNNGYAISTPAAEQFRGDGIASRGPGYGMLTIRVDGNDALAVRSAVQAAKAKAISEQRPVLIEAMTYRVGHHSTSDDSSAYRSKQAVESWKQMDNPLHRMRNFLTDRGWWNDALEEQTKAEHRKTVIEAMGRAEKKKRPQLSSLFEGTYRGDLPGNLREQRAELAELLEKYGALPGWSKELAKHANAGKDMEQYRENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIS2</accession>
    <name>W3VIS2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000027">
        <property type="protein sequence ID" value="ETS60641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIS2"/>
    <dbReference type="HOGENOM" id="CLU_042557_2_0_1"/>
    <dbReference type="OrthoDB" id="2551907at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="59118" checksum="AEB1854134E1602A" modified="2014-03-19" version="1">MTHPRLATYLAKGVSQTPLPPVAIALLDSLGEGAVFRWLVPLVVLSILLTRIAPSSSKGVNLATPFWKIGSPPAGLNLSGDAKDTRFSRFSHGEELSDEWRSRYGTQPHWTRNGGVTEVVLSTPAQVMSFYHRDAKLHTKRDSIGFGHYFGRLLGKCVGAIDGERWTLLRGIFDPHFTHRVSLSLGPAMLGLVEDWAESLSDSGGLSSFDLEAIEATSKLPFKIISLAIFGHVVLEEENFERLWSMVKLHEEIFQYAALHRWAKHAAYQACFWTRANRIMGQFQREFAQFCLDMVAKDTNSPAAEMHSRVKDKTMTMDEFTQTIDEILFANIDVTAAVIAWTLIHIAQTPGVQPWLLQDFVTQESATTRPDVLFSDYICATDTILHWTIMESMRLSPPTFFSLPEQSGQHKVLPGGGVLPAGTPVIIDAWTLNRRSEVWGTDSLEFDPTRFRDLKASDYRYSLWRFGMGPRKCVGQFFADKIIKMAVYSVLKRYDLKVHGDAPSPRHDRMTNTPQGRLLFTPRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ49</accession>
    <name>W3VJ49_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ49"/>
    <dbReference type="HOGENOM" id="CLU_114179_0_0_1"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="180" mass="19208" checksum="4D16F97F3CE79958" modified="2014-03-19" version="1">MSTISNQHALSGVEGTHTDATENARYSAPSPPRAKFDAAQLQPHLTTTLNSRLRHATWDKSDKERNRALSRSIAELVKAKMLGACLLFQRSPPLAAALLTASLELALRQRSSQKVARTVSIPSQGGTPSSLSSLSAAGFKYIVQVQLVENLGQGGRCVALLHHIGIQPGADTLFSHCAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ60</accession>
    <name>W3VJ60_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy protein 5</fullName>
            <ecNumber evidence="4">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">TBP-associated factor 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Transcription initiation factor TFIID subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">PaG_04751</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 21">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="21">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002514_0_0_1"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.190:FF:000003">
        <property type="entry name" value="Autophagy protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000347">
        <property type="entry name" value="Autophagy protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 21" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Gcp-like" evidence="23">
        <location>
            <begin position="67"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="27">
        <location>
            <begin position="573"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="26">
        <location>
            <begin position="730"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="25">
        <location>
            <begin position="877"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="24">
        <location>
            <begin position="1576"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="831"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="959"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1082"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1260"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1467"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1495"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1083"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1135"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1260"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1283"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1349"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1376"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1426"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1502"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="174"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00093657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="ETS60837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1671" mass="174070" checksum="E4466C0E0A1ACD6B" modified="2014-03-19" version="1">MPSRTRVRKPDPLPYPTRPYLALGLEGSANKLGAGIVLHKPFDPSAPSSSSSSPSSISSRSVGQVEILSNVRHTYVTPPGSGFQPSDTAKHHKEWIIRVISEAVRRSGLESLAEVDCICYTKGPGMGAPLQSVAIVARTLALMYKKPLVGVNHCVGHIEMGRTITGAHNPVVLYVSGGNTQVIAYSAQRYRIFGETLDIAVGNCLDRFARVIGLSNDPSPGQNIEKEARRGTRLVPLPYTTKGMDVSLAGILSATEAYTRDKRFKPNVDSSADAGLPVGSLANGEVWTGEGGGKHIVNMAEGSAPDAEAQNKGDEEDAAAAPTDPDVDVSQSGVAQLDSSVDNITAADLCFSLQEHIFSMLVEITERAMAHIGSKEVLIVGGVGSNQRLQHMMGVMASERGGSVFATDERFCIDNGIMIAHAGLLSHRMGIDTSLEKSTVTQRFRTDTPNIAWRASLASIEGAFHHAATMSQPPLASSQQQSASAGNYPSASSTPVTISAAASGSASATSTPLLGHGSLSAGSPASNLLSSSPHTGGFASAATSPASIALTAAHSSQPYASPAQSTASFRRLVWEGSVPICVSIDPTDLPPGSDSSVDSTYLVVPRVSYLPLIVDDVKKNLLELALEQPALNSLNDKDIWFEYEGQPLRWHWQIGLLYDFHTANPARTAVAYTSSASSTSGLGSLRPESSTQPSSSSVESALQPPRLPWKIRVRLSKPPTERLHSNAGVESCKTSFMSMIKEADFVRYGSTKKVVNLRKQEQDTLWDGVVAHDYELFWSVAQKLVPNAAIIGTQTGTATATAGRSPIASRAQSLNLGGGAHDERSTTLAQRSFTSQPNESEASLAPSMASTITSTTSSDPPADSGTATPNANNAVRSIPLRFFLPDNAPIVQEPVPPMLEDGRANTLGAVLSALFPLMFPPPPSFSSFQAPSPPLAYALVQGVRMPLDAEIAWLGSAFQGQQGQQPGQQNASAPGQQLANNQMPPGGPQTAAQAAQYKAALIQQQQIQAMRAQALAQQQQQQGQSSAQPQQQPQQQAAQAGNLQALQALVQNNPQGLAALFQAAREGKISPEQLAQLKAFIGAHQQAQQQQGRPPQQQPNQPQQPQQHQQAPQQQAPMNAQLAQQMRPPQPGQPQQPGQPNMQQAQMTAALQQQLQQQQQRNAQNAQPQQPNPALARPPQGAGAPGQPQVPQTEQALLEQFNRIAQPLRMKVQALESALNNPNLKPEERQQCQNALQETRNQQAALAKQIQIVRESFRQQQSQAQAQQAAAAAAAGGKPPTPVQQAAQAQAAGVSAATPQSASPAPAPAPTSAATPATPVPAAAAGPKAGANSAAKPTPKPPAKSKAALKKEKEAKEKEEKEKAAKEAAAKEAKGKGAAAKGKAAASPAPAAGVGAANGAAKPSPAATGGAAGARPGVPVPGPGPAGATATTPTAATLGGTPVTAMSAAAASYANVAIPPVLNVSTSSAPEPYPNPSGPRASMTQGLGVAPVIGTPAILTRPNPTGPGSSDDTALDDLLGLPSRPALATADELLGLPAGDDPSADVASAAVATASAVLSSSAPAASAVQNSNGILTKRKIADLIAELDSTEKLDGAVEDLLLELADEFIDSVTAMACRLAKHRRADKLEVRDVQLHLERNWNLRVPFPGAVPIPPPRTKVAPATTSATAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ71</accession>
    <name>W3VJ71_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04691</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ71"/>
    <dbReference type="HOGENOM" id="CLU_254240_0_0_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06917">
        <property type="entry name" value="STKc_NAK1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035062">
        <property type="entry name" value="STK_Kic1p-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF21">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="629"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="363"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="540"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1124"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="658"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1255" mass="133476" checksum="A3EF1C3F86487D47" modified="2014-03-19" version="1">MSLWSLSAEAGPSRPTQAPLSPTKMPVANKHESHVPTFLVRSATEHDLYHAERKSLHTFAYGGLAQSAPSAEASNGISPPPFYRATFSNPSSSSVSSGGHPISPSHRTSFSSVSVSEFGGSAMSDRLSWGRSFKRQSKRASHDAKFASSSRLRSHTEGSQFSLPNSGDIFLYSSHNIQASASDKTIQPRYSHQRRKSDGPQRSRFDTGEMSLPSRSHRLPRSQSSNALSHAFWDARGSKHQPKPTTHGLSLVKDEDEDGPATVPRVASIPSSPLRESQTFDAADRLAMMASSSPSKALRRRSGEVVSGAARSAAQATKRSLRVIRRAGSFDVASKTSTANTRSRSNSSSSLLTSLGLVSMRHQRSQTLHELDTPFKRERNAAATEPPASLSLPASAPHSPRLHGLGLSADSNRASAWRFSQITEADENISFSKDLPHLAQETGSTPSSESDQGLQLHHSNSSGGSVPDARSITPPKRDGHLEAQARSPTRSERERRQGLAKRSYAALIDLLNPALHKETRPIGRGRQHSLNAASVEHTVAHGDDGGRSISAGGNSSNGAGRARGGSASRSNGAQEGFDAYRGGNAGGGGGAGSGPGGAGGGGPPDRRGPGRGGGSNGASKISAPVNSVYRRLELVGRGAYGAVYRGVHVESGAAVALKVVNLDTPDDDVSDIQREVTLLSQLREATQRNVVRYWGCWLKGPELWIVMDFADGGSVRTLMKAGPIAERYCAIIVRETLVALNYLHKCGIIHRDIKAANILLTSTGKILLCDFGVAASLASSSHSKRSTFVGTPYWMAPEVITEGKTYDQKADVWSLGITIYEMATGNPPLADVEQMRVIMLIPKSKPPRLPEGGDFSPAMRDFVAACLNEEPKERATSEELNKLKWIKTHAKTPVGVLKELIQAYNAWTKAGGMRMSLIGAETADWGEAGNRDSFAFDGRETGEGWEFNTLRGAREWDDDEADEVPAQIPIRDHPLLRLFEVDAPDGAAGGQRGVQVEHNTWRPVNATAAVAPGGTVRAAPAAPAAPVVPVEAPTAAGVSTIKAGVGGAEKASFTGTGNTPFRFGVGGGLPSGVEAGEVREVPLRKRSQSLTKPSTNSADGNVIPDSRSLLDLEAGACKLQGGDEHVAHHRQSHGGSDPISGAASPARLQSLYERGANAQAYSRIARLRAGYVASLESEPQVQVQVEATTPTVPREVKVAWERRLEGPPLRPLDFAALRTKDEVAACLGRTVDELGKWLDVMSLGLGRAVHAEPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJM3</accession>
    <name>W3VJM3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJM3"/>
    <dbReference type="HOGENOM" id="CLU_1070048_0_0_1"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="262" mass="29709" checksum="841898E23F5DD92A" modified="2014-03-19" version="1">MPQNDYIEEHIRRHGRRLDHEERQRKRAAREVHKASAVAQKVTGLKAKMLNKKRRNEKIQMKKTLKAHEERDVKQASTASDPNQALPTYLLDREGQKDAKALSSAVKERRKDKAARYSVPLPQVRGIAEDEAFKVVKTGKRKQKGWKRMVTKPTFVGESFTRKPPKLERFIRPMGLRYNKAHVTHPELKASFNLPIVGVKKNPQSPLYTQLGVLTKGTIIEVNVSELGMTTTTGKVVWGKYAQVTNNPENDGCVNAVLLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJP3</accession>
    <name>W3VJP3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001204_3_1_1"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="786"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1786"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1786"/>
            <end position="1798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1811" mass="196163" checksum="8A33F6B9B9AFC307" modified="2014-03-19" version="1">MALPPSSASSAAASRAHTPVGHRRSTHLAVGLPAQNNDAQAGARTPDRHDGAGLQAHKLHLVLSEITSVTSTVRKATRWNATTSAALTRITSYSYSAAQTPQAPSQPRPQQSTVGDSQQAPGADGASAGTSSSARIALRGMQRGATVDAASSSSAAARRLGLTLGVDGKSDDPVSLLTAFATLKAQLRACRDFAAFPLPTLLAPFLRLILSPRTSAHVTSAALQAVHKFLVYGVVSLDAPDAQIAVAEIAHATSHCRFEASEATTDELVLVRILSVMRELICEPTQAPAAATPTEAQRRHPTTLADCLGDDSICEMMETGLSMCCQTRLSEVLRRTAELSMTAMVRTLFSRLPVLPHSADEFFVSRSDGKEPEPEHATLAAEPVGEDAEQDEKKRRRMTMPDPTSNAFPAAAKQVLDQLREMGEEEDAEQTQEQPQEQAQEPAPEGESNAPANPQNADETGSQPAQDASAIPAQAEQSATVEPTPAEAAPAEPIHIEPFGLPAILEVCRVIVSLLDPNNLQHTNTMRRLGMSMLISVLETAGRSIGEFPSLRALMQDTACKYLFTLARSEDTIPLSLSLRALSTMFETMREHLKLQHEYFLNYLMDRLAPTFPLALEPWNERSFDSVARRALAAESISRTGTPDPGAAAAQQQQPTPPPAPPAPPIPKGSDRAPATGEARELYLETLALLFRNFDSDRAAEYLVDLYLNYDCDTDCDNMYERMLHFLCRSIHAANPQTAGQQDPVQLFALDALLSFVAATADRHEAGRTGSDESGTSLPGGASVEALAQQKAKKATILDGASRFNAKPKDGLAFLEREGLLDYGDASLSREERVARFLKECPRLDKKLVGDYIGRPDNVKVLEAFVRLFDFKDKPIAEALREMLESFRLPGESQQIERITQTFAATYFAAKPDGIATEDAVFILAYSVIMLNTDLHNSQNKRRMTVDDYRKNLRGLNGGDNFELELTGAIYESIRKREIVMPEEHAGSLGFEYTWKELLRRSRTAGALVACNTTAFDRSMFEASWKPVLSSIAFAFSTFADDYMVERAISGIRQCGILASEFDLVEVFDFMVHTLASATGLLDSSVPQTLTSNPTVEVENQRVTVSPLSTRFGVNFKGQLAAVVLFTIANGNVDAIRTGWSDVFEIFKNLFAHGMLPASMVMMEDLADGQVAIPLKPKKIPGPSPQDPRVQGGGLFSTLSSYLLSPYSNTNEPAPYEATPEDIEATLSSVDCIASCRLEDLWHQVLQLSTESHLCAVHYLRFLIEALTVEKVLFRESAGWNTDGTSTPSSVHGAGNGKSNAKDGRLQPMAASSSSSLAAGGAASHGAAGGLPLAYDPRVPFLLELLAQIVVSSPGQLVAETWPWVAEHISAVLRNAKAYHPMVVEREVAALLRIIAAAAGEESLRDQIFLALDLLRELPVEIRISGSKQLLAGLTQVLSRHPGFVRSHTEWSLVFALIADNSNMRNADSARLAFEATKAAVAAPAEKGGSGVTADNFVPAVTQLVEFANGADTAAWRNMMLRESPQRRTTLTEKKEMADAEKVQQERGVEAAAALEALKSEIPRLVAAEAEGAEVDAAWSKYWHALLGGLARQWTNAYAPVRSTAVTLLQRALFSAELVSDAHAAPSRTALIAVVFTQTLFPLIEELLKPQVYQIDPPSAANKNGGMLEIRIRASALICKSFLHLIPHLAPHEGGSRDEFEKLWLDLLDLMDRMINSTGGNAGRRNPLTEAIPENLKNVILVMETSRLFEGAEEEGGKRLFRLTHDRLQRFLPGLVDEVFAAQDAGAAAAPQPQPEAQADVETAAHPQDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJT8</accession>
    <name>W3VJT8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJT8"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="68"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="123"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="330" mass="35662" checksum="053DEC43930F1953" modified="2014-03-19" version="1">MSKPQVLVCGTIVHAHDELKNDLGSVAEILHLDTPSRAEFVKATAEGGKYANIVAIYRHNDSADKIGVFDAELINALPASLKFVCHNGAGYDQIDVHAAKARGILVSHTPAAVDDATADTAMFLVLSSLRQYYRAEVNARSGKWKSGLKPAHDPENKVLGIIGMGGIGSALAKRAAAFDMKIIYYNRNPNPNADASYTYVKSQQELLAQADVVSLNLPLNKETEKSFGKTQFDQMKDGAILVNTARGGVVDEEALIDALNSGKLSSAGLDVYPAEPKIDERLVKMDNCILLPHMGTETVETQKKMEVQVFGSIKTALQSGKPSFIVKEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK29</accession>
    <name>W3VK29_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_03959</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 16"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001935_1_1_1"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12 15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 16" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="19">
        <location>
            <begin position="711"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="20">
        <location>
            <begin position="957"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="192"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1435"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1511"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1364"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1453"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1476"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1511"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1564"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1607"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1649"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="15">
        <location>
            <position position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS61855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1674" mass="184746" checksum="BBF96741633585BE" modified="2014-03-19" version="1">MHPVVFGDADERRRGVAATLVPPLRLGAPNTCDFPRVVRACPTLPSHHRLKIPPTFPPSFPPRVSLLPILGPAAVTPNAAAGILDSQRTFTIPFNSWLPGAASLLSTTTKLTLRRGSSVGAAWLSRLLPPASPSHLSSVYPWAAPSVSALLPALPSPSSFRGFAATTVKMSDYESDASDSFALPAPTKKAPAKAKTAAAKPKAAANGAAKPAASKANGVAKPKKQPLAKRNSNGADSDNDVSMMDSEADVSFQPPPPTKSANSKSASETYQKLSQLEHILKRPDTYIGSVEKHTEKLWVYDKTKQQMAYRETTYVPGFYKIFDEILVNAADNKARDPNMNHLKVEINREENSIMVWNNGHGIPVEMHDKERVYIPELIFGHLLTSSNYDDNEAKVTGGRNGYGAKLANIYSTEFTVETADSKNQCKYKQTFSRNMHDKGKPKITPHKRQDEYTSITFKPDLALFGMDSIDDHMEALMLKRVYDMAGTVKGIKVTLNGELLKIKSFKQYVEMYVTAINELGGSADQGENGAADMPVGATAKPAIIYESTVDKGRNWEVAFAVSDGEFRQVSFVNNIATIKGGKHVDHVADQVITRLIEHVKKDKKTGKVLPNQVRQQLWVFVNCQIVNPTFDGQTKETLTLKQSAFGSKWTLTDEFARKVIKSGVVDNIVSFARYKQDQALKKTDGHKRTRITNIPKLEDANNAGGRKARDCTLILTEGDSAKALAVSGLVEVGRDNYGVFPLRGKLLNVREASHDQIMKNSEIKAIKEILGLQHGKQYLDVNSLRYGSIMIMTDQDHDGSHIKGLIINFLDHFYPSLLKIPGFLVEFITPIVKCTKGKQELSFFTIPEYMTWKEQHNNGKGWRIKYFKGLGTSDSQDAKKYFRAMDKHMLPFDVTKDGDRELIDLAFNKKKADDRKEWLRQFRPGTYLDHNIDTIPYADFINKELILFSMADNLRSIPSAVDGLKPGQRKVIFGTFNRRGDGEIKVAQLVGHIIGTTAYHHGDASLTMTIVGLAQNFVGSNNVNLLEPRGQFGTRLLGGKDAASARYIFTALPKITRALFPQADDALLTFLDDDGQSIEPEWYMPVVPQVLMNGAEGIGTGWSTSVPNYNPHEIVANIRRRMAGEEVVPMKPWYRGFTGDIDEVAPGRFKVSGRVTQIDDKTYEITELPIRTWTSTYKEGLEERIVSTDKVPATIKDYKEYHTESTVHFIVELTAKGQAEIADKGVEAFFKMSAQISTTNMVLFDQDGKIKKYSTPEEILEDFYLLRLSYYQKRKEHLVDQLKLMYDRLSNQARFVQMIINRQLVVSNRKRADIVADLRKNDFRPFPKQGKAAVAAEIEDAEPVDESDISADSDYDYLLNMAIYNLTKEKVDKLLNERNAKEEELRVLIGRTPQNLWDEDLTNFLGFWDEMLAEDERRLKDVSFKVQKGKQVKKVAPKGGAARRVLKKPLNSDGEEEDDVAMDGLDDSEDDFKPAAPKKKTAAAKASPARKRAAADALDDDDMARLLGTTKAATAAKKPRANATASASRSATVSRATTPQVTAGADLSDDDGDAKPKLAPLFRKTATTAAAKKGAAAKAKAAPETFSLSSDSDDELIVAPKTKKAAAKPAAAKPAAKKAATGAGRKKAAALASDTEDSFSLDSPEPAPRARATARTARTASSKLSYNLDDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK78</accession>
    <name>W3VK78_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK78"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="158" mass="17230" checksum="6E9841DFC3852946" modified="2014-03-19" version="1">MAMKRINKELADLGRDPPSSCSAGPTGDNMFQWQATIMGPGDSPYAGGVFFLSITFPTDYPFKPPKVSFSTKIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIANLYKTDRQRYESTAHTPCKVVFGSNTAGSTPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKC4</accession>
    <name>W3VKC4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKC4"/>
    <dbReference type="HOGENOM" id="CLU_2097859_0_0_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="116" mass="12440" checksum="4FB1F7A506F49D43" modified="2014-03-19" version="1">MLETSQANALVYSTLCGFMLVGLYAGFKVRNTTDFLSGLRTQSVLPPSSHRCIQRTRTDARREAGRPLAIGDPGLAATFCPNTTGTYPSRSPFLDHLGSSPPVLLSPLGSTPFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKK3</accession>
    <name>W3VKK3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKK3"/>
    <dbReference type="HOGENOM" id="CLU_1050214_0_0_1"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="265" mass="28111" checksum="12882DDFCE255FFA" modified="2014-03-19" version="1">MATTTASGSGAEASAPKPRMRNDKRRAANLLRDYYGLSSDAPSASSSPSLDSTAGDSKKKGAGPDVDLNSLLRSNSLSVLLGKESELIVQIRELDGERQSLVYNHHHELVAASDTIRNMKLRSESLDPSLDSLKSCFESMSTLSSHLDSLRPKPPQPSTHPTIDDDGQALRDLDLEPIVTLPTSLADLIECRHAGADTDAAPAPLQPDAEARRAGLAQAEHLWGTMEPVLAAWTDAGVSGVREVAAECRALLKDGRKALSSPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL07</accession>
    <name>W3VL07_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL07"/>
    <dbReference type="HOGENOM" id="CLU_038782_1_0_1"/>
    <dbReference type="OrthoDB" id="5427593at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24051">
        <property type="entry name" value="ASKHA_NBD_LGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="445" mass="49186" checksum="67F30E8D7E5C78D4" modified="2014-03-19" version="1">MTITNGRANGINGHGASPGLDLTVLGLNSGTSMDGIDCALCRFRQQSPEAPMHFELLKYAEIPLEPKIKKRVMDMIYHNRTTPEELSEVNVLLGETFASAVQQFCNETSVAMESIDVIGSHGQTIWLLSMPKPGQTKSALTMAEGTFIASRTGITTVTDFRVSDQAAGRQGAPLIAFFDALLLHHPTKLRACQNIGGIANVCFIPPDNEGGIDKCFDFDTGPGNVFIDAVVRHFTNGSQEYDKDGAMGSRGTVHQPLVDEFLEFEYFKLEPPKTTGREVFRDTMAHELIQKAEKLGLSQDDIVATVTRITAQAIVDHYRRYAPRQEIDEIFMCGGGAYNPNITAYIQQHYPNTKIYMLDTAGVPASAKEAITFAWQAMEAVVGRSIPVPDRVETRQEYVLGKVNPGKNYRNVMKKGIMFGYGDRLPPVTEMVNYVDGEVFNNKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL17</accession>
    <name>W3VL17_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008112_0_0_1"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="164"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="698"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1418" mass="154661" checksum="C49572D85D817A4A" modified="2014-03-19" version="1">MFTTPSRARDARSSTPLAGAARSGNRPSRAGTPVFGSHDPISPPSFLSPSTFRRDDNTQNDAGDVSATSLFLNGARTRTSRARPRPSSMLAASAGPSASLLSPSDAFDREGSVISEDADMRSVADTVHSASHAGYNRRSAPAPKDAKTQLDEGTVLLGDQWLHVSAYSRLPTEVLELLAEADMYIDAFQGHLDVHTGYACLLSRTQCFVWNYASRGIGTGSPTCFVFPVPQYASSSMSAINDLSHACFLPRGGAEREPALLLVTPDGQTCLWEGISSSLTRQDRAQRIAAPLSSGEAIVKLQRIDESTVVLATSASRLLRVSVGSRAGILQAEVRPFSQPRGLLGRIFGSSSAMGSANDHIQGIAVAPAQASKQGREVYAIGRKTLQKWHVLDQGGERLLAEQDVQQVVASSVLQLNDERYSAAQSLAFDLLDGAVQADGKLVLLFSQSKTEHEPLQYGLATLDVVKDAASFVVASIQPIKYTSYADPRPYATPSLSLPNGGPAAFITFADAVVAKQLEDGCESFEELIKLKDDVKNRFIGSGCDAVHVSANNAVAALSLISAASGSLLVETSIDAIRKRCTASATAADRQRADTERLKGKLEQALYYSESPLNPLTFRLPEHLQGTLMTACQDLSRELLTFSNPIAQSVPPPVDLRAALKDRLGKLRFLVEFVARCGHLEKLPQTTKRQLRADAELAAALAELWVYQNEFYSASHAQASAAQSPLARAIETVMAEQGLGVGSDDVVRRFFRHHADLSPRVLDRLLRQANTVSAQPLRTRSTDVLELNRTVLAAFRASLRYRKEHGRLYGIDANKDAAFEAWTAQSGSVQLLETLYSISVNLIPDRTRELGSSIDVAPTEYSGAGDEVKREQRVQAELKAQLCTLADVAMACYEERLRYLQAAAAADAAYERELSVFGATLRSARPMFIRPLVGIGRSDRAFALAEQYEDFRTLVELCNEAQLRSPARLDSYLERYKQPFAFELYAYYLEHGQPRVLLEQKSEHSQLVLDFLAQPGHERIAWLHDLALQRYGEAAHTLERLALGEGVLAQRKLMMSLGKLGVLSTLTLQDLQTVGTQKQIEFFDDQLDLIAVQDSLATLWENALGGLPADLPAAGSAQARELATEIVEAVATRLREYPGYREHYVELVQRLLFENRYLGSEDLVDVLTLKDTPENQLEDFATALKVLVRAKDAPEPRLREALKAVWRRAVVRDDWFALSETTNVSDQTVLADLQATALYTVLGEVLADDANRSAYLAVHELVGDGQDAKALVAARMADKGDVEVDAIWHDRQKEQATVAAFLDDSDLPRLAVELARIAAGHDTADVEDSMALEGVDSDEAAEVVRASRSAVDRFRRLLEQFHPKPPTTSVRLPQPPPAFDPIIVAAPPHSLPLPVPKVPVPEVNHPNVKNPLRKAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL32</accession>
    <name>W3VL32_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanyl nucleotide exchange factor Sql2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03811</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002632_0_1_1"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="48"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="1252"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1418"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1106"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1117"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1143"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1156"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1216"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1670" mass="180250" checksum="256DDEFA891680AE" modified="2014-03-19" version="1">MTSASAAASYVNDLHYPSHAHSSAQSRLAYNTMPDDHAPSTADDSDEPPSFFVRALYDFESNDASSLSFQKGALIEVLTQLESGWWDGLLDNQVRGWFPSNYVEPISDREAAVELAARAQLTSNFHLGLSSQPSADSDSFARLGFGSGFDGLQALIKGDGIGSSDAFSQLAEAAMLDPSRRVFDHNSPQLADAHSDASPYRNPSAPNHLAPESSASASLAALSEHRLALERDRARAASVSNPVEVNTGASTSLAAAAAAASARPRAATGSNATDAWAQITSTSRGARTGAAANQLPTLGVVGPESGAESLAVANQPPSVLRSSSSGQSSTADAQHLAPDGSRTPSLRTNDSRPSSSTNSRPTAIFQNGSAPVRAPASNAVDRMPDPVTVPKPWKVRLTDDEKYFFFVHRKTTEIRWNYTDAKTKLTILSNVTPRSRSPAQPARSPASASTLNDHTKAASSLGGSRSLAQEVSELNLDSDESDLDGDLNPRLPGKPPKMAATDAARGAHASLGAAAFAHHPALSQPQAAPDTLSQEESAAYDLQKAMAPSPVAPVSLLVRHANEVIRQLAAIATEQVGTNGLAESDGPLWSPQSGVYLPRLAHATSSVVSAIRDVLYATGSLSLSTSDLAAICKLVSASPAEADSRTALAPDSPLEHKDIDMNLLSSVLQASHASAHGKGASTALQRCGVYSKDSLALIPSSLHPVGRKLNAVVSKLVLSSRQVIDHTVTLASSPTSSMESTMTDLDADVFSKLYQCRQRLREDALELMRTLQSLSSEAEKVRSTALSAPQSRGWLRRVEGSLESDLGLNGIGATSFGSGMAASWLGNGFVLPSKFEVALIKAEGKGTRKHNPFDQRREAESAVVRGMLTLRRIPDKRLDQQVVEQAQKLSSQLEATNDAIGVAAKPAAAAQSALSLLSQYGAFEALIEAIDLASILDVDGPSPGEAKSSSISARNLTNAQKARSLMRRLVTLKQTAYDLSCSLFIAVQEHGEETSTSSASSHLQREASRLTRLISTVSKTLEELVQVAEEQLRDASPYLGARAAVHGSEEGFSLPSTGIFSRKVNTTSNGLHEEVEEMSRYAANGGADAEEESEFMYLGPGIAVPNGPRARSGSRATTGSTGNSPSTSLGPARFGMSNSFRNRSTSVTTGGSSRSMQSYTDASSRILSRRGTLVDGSTAESIDEDSESVRTGGGKLRRLLGDDAPLTHTLTHDSENSAGTGNTGSTLARRKEDEVPWFLEPDYMGDDIVIAQDGSVKGATLEALLARLTMHNSFDASFNNTFLMTYRSFTTTQTLLDLLAQRFRILPPDGLDEDELALWTEKKQVPIRLRVFNVLKMWLEMHFYEGEDEPYLDQVRRFAVEEMGEIASMRAPSQHLQRLVERRQGEGEQMIRKMVLPTSAPAPILPKNLKKIKFLEIDPLELARQLTLMESRLYNKVKPAECLGLKWTKPGNEVHAKGIMESINTHNRISAWVAETILQQEDLKKRAALIKHFISIADRCRALNNFSGMWAIVSALSTAPIHRLRRTWDAVSQKHVAVFESLENLMSASRNWANYREMIHKLNPPCVPFLGRYLGDLTFIEDGNRDRLKENDQLINFGKRQKTAEVIREITIHQSTPYNLAVVPALEKYIETNLVDARSADDLYEQSLALEPREREDEKIARLLQESGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL47</accession>
    <name>W3VL47_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL47"/>
    <dbReference type="HOGENOM" id="CLU_096876_0_1_1"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="200" mass="21898" checksum="370740A56FD15F61" modified="2014-03-19" version="1">MSLPRRSYDPRRVCLVPLPSLPAFMQTSKRQAGIYLSGALFALGWWFFLDASIISSMRLRKPIDPTAPYDPPATYITFADWVPGLCGTLGMIVVNLIDKQHLTDVGAAFSFGGGGGGSFATDSVQWRARLFLFIGFALMAGGLAGSITVLTVKYLVPALPEGYEYYGVANVVQNACIMFSTVLLWLSQNTESEYEYNLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL48</accession>
    <name>W3VL48_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL48"/>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_1"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="221" mass="24671" checksum="2FCB1AEECC9CF682" modified="2014-03-19" version="1">MPGLRLGSIAPNFTAETTHGVLNFHEYLGDSWGILFSHPDDFTPVCTTELGEVARKAPEFEKRGVKIIGLSANDIASHDRWIKDINEVGNTSVNFPIIGDKDRKVSTEYDMLDALDPTNVDAKGIPFTVRDVFVIDPKKVIRLKISYPASTGRHFDEILRVIDSLQIGDKYRVTTPVNWQKGDKVIVHPSVQGEEAEKLFPGYETVKPYLRFTKDPSANSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLD2</accession>
    <name>W3VLD2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04313</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLD2"/>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_1"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="10">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="881"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="488"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="917" mass="100697" checksum="8CC8977A7EDBF4F9" modified="2014-03-19" version="1">MSFEFTDRAQSSVSAALQLAKDHSHPQVSPAHLALALLTDDTSNSQGVQSTNESSQSLFKSICTKAGVDIKILEDKLRTALRKVPSQTPPPDDISLSSPALKVLKEAENQKSTQRDAYIAQDHILLGLINDNTIKQLLKEAGLANEQLIKTAITQARGGRHIDSKSAEAGYDALAKYCTDLTQLAAEGSLDPVIGRDNEIRRAVRVLSRRTKNNAVLIGSPGVGKTAIVEGLAQRVVDRDVPPNLLGKILSLDVGGLMAGAKYRGEYEERVKSVLADIEKMTADGTPCILFIDEMHLLMAGQGSSGGGMDAANLLKPMLARGKLRVIGCTTANEYRQYIEKDAALERRFQSILVNEPSVEDCIAILRGIRDKYEVHHGVRILDPAIVSAAQLAKRYLTDRRLPDSAIDLVDEACADVRVSRETVPEEVDKLERKRLQLEIAVHALSREKDAQSKQSLDETRRQIQAIDDELAPIKAAYEAQKAKGDEINSVRRKMEEVRAKIAEAERRYDLATASDLKFYALPDLETKLQQLQAAERRREEEGRDADNNAVTADAIASIVARWTGIPVSRMLESEKSKLLRLERTLAKEVIGQDEAVKSVAQAIRLSRSGLADANRPIASFLFAGSSGSGKTLLSRTLAKCMFDSADAMVRIDCSEFSEKHSISRLIGAPPGYVGHEEGGVLTEAVRRKPFSIVLLDEIEKASREFVQLFLGVLDEGRLQDSQGRQVSFRNTIIIMTSNLGSAYINEAEEDEMGDATRQLVMGSIKAALPTEFVNRIDSIVVFSKLSRRNVKAIVDVRLREIEQRIVANGGKSKLVLDDAAKDFLVATGFSPTMGARPLNRSIQQELLSPLSILILSGRIDIKEDAEIRVRFDKHRNGLVVEPNHEASTSNGADDVAMSDSDEDDDEYARIEEDPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLE2</accession>
    <name>W3VLE2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLE2"/>
    <dbReference type="HOGENOM" id="CLU_007871_1_0_1"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="836"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="90"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="521"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="868" mass="92648" checksum="9E6FC5CFA50725E1" modified="2014-03-19" version="1">MQSSMMGGTPMANAPSNFGVAPGPSSAAAAASNSLPNGALKSPNPPGYSSAEAAANAQGLVYPALHLHPLNDTFAPKQISLAPPGPNNRIKVGRQTNAKTVPNPTNGYFDSKVLSRMHAEVWSQNGKVYIKDVKSSNGTFINGERLSPEAQESDVFELHNEDMVEFGIDIVGDDNKTIIHHKVACRVYLVLTAEDALSLRHDFASLYRGGMHGGPLGSNGVGPGAEGGLRRSKAGFSFDHVLSKLQSELQRSKDTWNDLGSLTTTMHDIHETLGGGPPPLASAPYPHMVPPLPGAVNAQQQQQQQQQQQQQDEEQQRAKDAENHAVNEAHSATISALQAQLSETQNSLAAHVDKIRSLESILSEHDSIKREVSTIKLQMEEARREMDAVASSSASRHHLNGFGTIRGAPPFGRQVDHDDFDDGASVASVETVTMDAGGGDDASGVRSLQHVGPRAPPDMPAHLTSEDAADVESTHAPEVSSANDADASSALSTTDAQPGAHTDDSSALTQHNLAKQNGERDLELRAQNEALSARLEQLASQLEQALSLSRGLQEQHAQVTDTVKTLEQRVHTLEKEVEHKTATMTSANDASQQSTAALLNGFESRWTEFRTEFDESWRKEREGLQTERDELRQVVRAWDEANRRMEDELNNTDLDAHAEDTDSMGSAASASNHDTAPSDPSSSASHAAVASDASASRSKRGHGRRKRHVNSALRTLLYGSASAGLMLGTGGREPDEEDQWDAATRARLSRRSPDEDAMSTSQSVRSVADSTSTRPSTSTEVTTPELGADTCRGEAGLDVDHAKHEGSHPRSRQLRHAAAAGTGESSRHVNVVGPQTLAAAGVVFVGMAAFILAGKDLSRFNGALSGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLI5</accession>
    <name>W3VLI5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLI5"/>
    <dbReference type="HOGENOM" id="CLU_337421_0_0_1"/>
    <dbReference type="OrthoDB" id="2552394at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF3">
        <property type="entry name" value="CLEAVAGE_POLYADENYLATION SPECIFICITY FACTOR A SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="843" mass="89537" checksum="7AF8C9C39DB216D8" modified="2014-03-19" version="1">MADRLCRCGCGTHAASSSRFQSPGGSHISLATSVSSLQPNIARPLSAPAQPTRPRRRAASPYLQPMLLPDASDPQHEAPTMMPVAQPSSRRTRRHRLHAHNSSGFLLLFLSLCALIGATVASSAIPSMTPSPALPTPKAIHTQPSPAAPTPIPTSTGANRVYQQLAAEASSSSAPPNHNVDVQVAQPVECDFMNITFDPSRGTPPYTVMISIEDYWPVTVSLPATYDDASKDLWLYQYPVPSFTGPTKNPSLIVTVTDSSGLMANSSAFVQVSSAATGASCAPLDYPGSFFFYTQGAASMCQDYSIFWNGSYAPPVTAVFLPELAPPIYVPAPSLTSSNMSWEVAMQGGTRFVMTLGDSRAVGGSGGVSKLNIVALNEYYTDACIAQANYQHRVFAPASTAPPASIFPDATSTLASLTTSGGIVATVTVIETIKNGRTVHGKGGGGLSSIGFLIAMIVVFVTFGLMGVALGWFCYRRRQKRKHNIKAWDLPNSDPSVPFNADPNMPIAPGVFGRSVTRQASTNTRNAADRASLSGVSNYDPVSLSSRPLGHAPSTRASLRSWTSSAFDHLQIATGAPQTGAHQPGHTGDYALMDAGSYAADAHAYSRGGHHARSPTSGTLSNSSRDAWSPTDSVPRTFGFYSDDPQTPNHLHSRTGSPPSVSRSTSTDGTSSKSTRVGAGPTYRPDAASQAAYHDLLASNTTRMNSVRNVAGARTQGWADLSGEQRDGRLAVSEQSTRIVRHSDAGLLLDDNDNGDELINLREGRVMELPPQYDTIHPSTGSHQRPLYEQAAQSYNGQQGGRPRQHMRALDSVDISDAGSRPAEVHAADLVDENDDESAFWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLN5</accession>
    <name>W3VLN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fumarylacetoacetase</fullName>
            <ecNumber evidence="5">3.7.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_03039</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLN5"/>
    <dbReference type="HOGENOM" id="CLU_295128_0_0_1"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="18">
        <location>
            <begin position="594"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="17">
        <location>
            <begin position="721"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="722"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="724"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="798"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="831"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="831"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="842"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="851"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="855"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="953"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS62425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113782" checksum="952FA2EEA3CB1015" modified="2014-03-19" version="1">MRFELSSENLANVPHVAWLGLALFVAHCLYSLTKRPKINLPGPRGWPYVGNLFQLGEDAAQTYYKWSKQYGPVYKVKLGEREVVIVNSAQASKELLTDLGSIYISRPLFYTFHTVVSSTAGYTIGTSPWDESCKRKRRAAATALNRVAVQSYVPIIDRETLSLVEDLYSAKGKAIAPFAYFQRLALNVSLVVTYGSRLDKVGDELLEEIVEVETHVANFRSVSNSPADYLPIVRYLPNFGRNGKAFASSIRSRRDVYMKRLLDDLRDRVQAGTDIPCITGNILKDPEAKLTDLELSSICLSMVSAGLDTLANTFIWSMGFLAKRPDIQEKAYNEMYKVYKGEIPSSEEETVEYITALHKECSRYFSVLKLALPKATLGDSKYKGVDIPSGTTVFLNAWAIHHDEERYGDVENFRPERFLEAGEENKQAHYSFGAGRRMCAGVHLANRELYIAFCKVIHFFKIELSQDPAEQEYDINPATGCANPKGLSSTPKPFKVRFVPRDPATIEQWIENEKSRTELQMATSLSNKTPLLAGKSKQHLRSFSTHLARPPSSYIHVLYLALPSNLLWSELDADTLAAMKCIVDYPKDHPFPIQNLPYGSFYTAGDASSQRCGVAIGDYILDLQALSYTSHFPPDLDRDVFAVQPTLNAFMGLEKQAWLQFRSSLQQLLSQPSELSLDATVTAADVETGIALPEHIGRRLFVDRLAQDTVPCLPCRIGDYTDFYSSLEHAYNCGVLIRGKENALQPNWRHLPVAYHGRASSIVPSGTPIHRPVGQILDKPGDTAPIIAPCRRLDFELEVGFFLGGPPTKLGQRLSPAEAADRVFGAVLLNDWSARDIQTWEYVPLGPFLSKNFATTISPWIVPVHALEEFTCAGYDHQPPLQPYLEDGSNTNFDIPLTVALRPCESDEAGEAGYRVISHSSLRHTYYTVRQMIAHHSTTGCPLHPGDLLGTGTLSAPGTEGYGSLLEMSHMGRQPFGVQSASGEVQRTFLNDGDTVKMSGKAVSQTGEYAIGLGECVGTILPAIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLP2</accession>
    <name>W3VLP2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLP2"/>
    <dbReference type="HOGENOM" id="CLU_997927_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="279" mass="30117" checksum="AA63DD0FB9C8990C" modified="2014-03-19" version="1">MWAHQSARSCVSHAKKQANDGDIGAFSDNGQRQATSRQMDDYREGPYAACIKHSLLGMATSTDAPPTRRVFVARLSEVVPNVDLREELGDTQGQRPAMTSRPHDLTTIRECFDSTGSLQALTIDPANHPLGCRSSEAILSALMLVMSSESFLIPQAFASVCSECSFQTRNRRCLLLAIVRSVLWGVASDRVGRVEDAFMRGTRCEKAPTLFVGIARPSCKDAHQHQILHVIRPVALGVAQGAGKIAMIPRASLAEKVGETPVKSADPSSTPTSAASAMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLW9</accession>
    <name>W3VLW9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLW9"/>
    <dbReference type="HOGENOM" id="CLU_007948_1_0_1"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000039">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF8">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YRBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="36"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="302"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="400"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="502" mass="53046" checksum="4DB015C5523BBE6A" modified="2014-03-19" version="1">MLRRRGERSTQQQPARLHGYTNTADTPASGALYPASVFVAALLLLERAADAFIHSVSLLSSQLGISPTLIALLTAGAEWEELVVVVAALAHGSSNLAIANVVGSAIANILGAFSLGIIAAPNAIQFDASSRRFAIIHAAITTLVIALLLTVQLQHADTHAKLATQRLFENVVGLSLITIFVLYFVGLSWAIGRGMLAAPQPSDSESGSESADDSSSSSSSSSASASPSPSTFSDASSLPPARTRTRTRAQAPAARRSNPRTTATATALESTPLLVGSATSSNLAARLARRRRRAQLRSLRNLVAAFLLLSLAGYLLSHSVLDLASLLHLSDSLLGLTLLSFATTIPEKLLSVVAGLRSAAPSKQPPPPPSTSRPTPSIAPAAQRSPQRAQNELDIARSASSVLMAAATGSNIFLLTLCLGISLLFDRDHPSPNPLLQPTSPPHSHHHPLAASSVQWQELALLEVASLFLVLIAFTDAQRWQGLLLLLAYFAFLVFEFTYLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM23</accession>
    <name>W3VM23_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253848_0_0_1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1285"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="900"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1216"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1241"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1408" mass="156314" checksum="1750AFB58EA67132" modified="2014-03-19" version="1">MSADRGQDGAADHAPVSARPPQPPRFSSFRPRESASTAGPSSSTDKPPSVLSPLVSGASHKAGQHRNPKHSSQSPRKSERERERHSDQPSAAGPSFRGESSHTREPKHRDEKRSHHSHRDGDRDRDRDRDSGSSKDKRRRRSRSPRRSSRHSEHRSSARVESDSSSRKLRLDPSHPGESSTFDRDLFFTDTRGDPDALLYGQERSKVPRSHRVPRSVDALGVASRDPPTSERDEPRPNSPNTSSASFPPPSAPDFPLTAEAFIDINDDSYALGNSYPPPLPGAGIDISERKRRAQAAVDAVPTDIDAWLELVRCLPLVSLATPEAPSSSAASSQMPQIAAQAAASIDIQLSVFDRAFEAASSNHRSVRLHFERLRVVTQADAWQPSAVQAEFVRVLNRFRHTDPSLDMTTEASVVDIWLLYLAWLKSSWSIFQFDQLFDTYKDALDSLRGHLLSAAAAGPASDAVEVLAQGMLAILARLLNILRESGYHEYAIALIQANLHFGSDLDSAITEHTHRVWRPALEPNQRKQEYQRLVEVVRKAWDGGSIAKSTEVFSGPIPGSDRSTQMTTVQDAARGDHFATRWLQAETTRCNHRRAPARLEDLPTWDIEGDEIDPYSTVLFDDLAGFLLPLSSECHARQMLLDVCVEFTKPARSLMSEITSWSSRNCWSNLQLLPDFQGSIDASFWPRTLRRADEHESRSMQSANESAQTSVRKVLSLLSAKGIHLPSSDTSSSVLDDLFDSQALDPTLSIPDQRRLWVLRIYLELHPIATAVDEVGVRKLFERATSTEVGMHCPLLWRLWVDFESRCLDSALSIAQESETAEPKKRGSSKRKAEQKQVTRARSTCLDAIRACPASKGVYLAAFAAPLSRILTQQELVWIFDSMVEKQIRVQVDLVDFIPQDPATGPQEDEDDSDESRNDPFDPTLPYTKRDPRHEQVGGGPSASSDRSRPALEALQADSAHPCAIDLLQQQAQARPRSIGLEHLPTELLHHILVLSRSDKFAVASRTLRSICQYASVSDRVDYIMARWADRYVAHKIAHPCRAKHKACRRQTSRVIALWREREPAWSDFAATLTVEPCELDALRTAKLDLVTFAAELGICTVQVLERLVKCAAAARIPRALLGAYLRNGSANGVLVVHEALERLEVPQPQLPKRLFRHIDDYGYAEPKPSAVIERPKKRRRGRKGDVNDCTEVGQVSTQEPFPAWLTRLLQSVGRDAPHSTNPHTTEQAHADSAASNGLADDKRAHPSDEPDAIKASVGVVPKAAELELILTLLYQYGADASSHSGYPLAMAVHRGSYSLVQLLLLFGADPGCKDGLAVQIAIRNGDLDLLRLLIDGPFLDHDLSNLLPLQPPSAPPQLGSPVYRLDQARLRLAIQCKHWHVVDFIWHDQNVSPDIACLRLLDKLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM36</accession>
    <name>W3VM36_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03272</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM36"/>
    <dbReference type="HOGENOM" id="CLU_038421_0_1_1"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="195"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="489" mass="53246" checksum="D61A9FCA0813A2AA" modified="2014-03-19" version="1">MHGQAPSVSISQKPLRLLQEEKKGFERPSPPHHQDPTIPAPLAFGSRSLLLPRPLETTQEAATGAPTLLSPALAHTWAPPPTLFTMPPKGSKRSSKADAAAAASAPENAMEIDEPSSSQPSGSIANDPAAASIIDQSKSSAAVDARRLVEILPERMGSVAETDFPLHHPGEAHTFSLATLGERLKLIITRLSDASCEFDLIGVDASIANAIRRVLMAEVPTVAIEHVYIWNNTSIIQDEVLSHRLGLVPLAIHPDKVLMRQPGDDADDSNTVVFHLKAKCERNRNAARGETDPDKLYIGHNVYSGALEWDPKGGQEDDFADAPPRPVHDRILIAKLRPGQELDLELHCEKGIGKDHAKFSPVATATYRLLPHIQLLQPVPAALVDKFVACFPPGVIGVSGEGDERKVFVQDARKDTISREVFRHDEFENTVKLGRVRDHFLFDLESTGVIPPERLLPEAIRTLRAKIATLRKGLDHLETQGLDTAIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMK6</accession>
    <name>W3VMK6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMK6"/>
    <dbReference type="HOGENOM" id="CLU_020592_0_0_1"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="740"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="859" mass="91143" checksum="74C44D6BFB664C5D" modified="2014-03-19" version="1">MPDRERDDRQAERVRMCSGGKEQQQTGSVRCSRLELFIALEIAYEHACIHASPGRDLAAVRTLLQSVEGSREERGSRMAVPWPMQHLPARPLLGQTKPSTCVARQAVRLTTSALQVTTRSGDRPGEGWRACICAFQRGLGPCKMRLETGQAGMSQKGCLARQGPTGGGIFARRGDKITGSRVVECVWARAREPELESQSSLAAARCVLHAQGSPYVSMATLLPCSLGGRAEVAKHVRCTSPRDAPPLKPRIHPSILSYRPPLATHRAASGAVVTMTSASMRRLPMRMMEHHAPQDENAMPAAGMCALQAAASVSPSRVTKSAHTRSPSKMPTLSDIAARLNLDRDAVAPTTSPAKQLLASPADAARPRLELTGRITGSPKPLQLADRKSPLIASPTKLDSDAAVCLSPTIPSSGTCSPTKRMLANGLPSLDEIRDRMSRKGLSVTAEGGSPNLPCTPPSPTKQAFDAKPSTAEPEIQPKCKVAPSKPALQLATHTAPLHKPSATVGSSSVSATQYPLQHEWTLFFDSRAGGPPTPGLGPDAPPTTPVLSTSSWEASLRTIGSYAAVETMLGCFSKLHRPSQLERHTSYHVFKDGIKPMWEDARNARGGKWTITFRQRNPALVDRTWLWLVLDLIGEELDGDDEACGAVCSVKPRGDRIALWLRDRSDTDKVNRMGRKLVALLEIGKEPGVLVEFSAHSTRDDKQEGLFSVNNAVQQLRTPTVTTFNAAAAGLPEAPHRFASASPTAFASPASPSRPAFRPPPSPGADTSSSAHFARLAGQAGSSGSAAMFGRSPTGGGGLGSLGQSLGLGLGIGVSKSPSLSPNPNEAKGSDAGAAMSWRSNRTTSPTRQSTASPSKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMR7</accession>
    <name>W3VMR7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMR7"/>
    <dbReference type="HOGENOM" id="CLU_456436_0_0_1"/>
    <dbReference type="OrthoDB" id="2554856at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="573" mass="63251" checksum="E34E28CC00DCF7C3" modified="2014-03-19" version="1">MALNAVHIRASRPASELDAGYTSSKTIDDDHEAAWRNLRTGTVLRPPPRFVKATQLSESNQPSTSSDHNPPTLSQLYASLTQDSRYPRPHSPSLPPTPHPPHDDDQHVHAQGKGKPRLHDSSHRHHHQHHPETRHRSEWFISRALTKMRRSNHAPTQAAHTAVAQPPAAPAASSASSRRQRCQRCGDLLPANATPEDMARHRQSIGHRLGLNADLASASASEAPSPAASKSPTPAATPPPGSASGPTAAISLLEASMQALHRRSQNMPRRLCNAPRWKKIARDNVGHTMLSRMGWKEGMGLGVLESKRHQQTRDKLKQKRSNAVRLLLRQQASVAQPGPDGLGSDRTAIEPQVQEEWLQLISHQPSSSQRQLEPLPHEAAFPFEHQDHTREQQRQMAQSWLDGMAQTDADWFQHLSDEDRLALEQALLTGQITLQDIQTALGDITRDQRSSAHALADAAEGSALLHPVQVELRRDRVGLGAETAPARHRRRSRDEQGSVSIRRTSSPSLDMLDGAHKKPRSAAPASTGVVSRSSSRAAVHKRTAQLAARKKRQRETAHQQSKREWLDLRASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMS1</accession>
    <name>W3VMS1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMS1"/>
    <dbReference type="HOGENOM" id="CLU_354963_0_0_1"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="393"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="435"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="810" mass="87399" checksum="229BAD64E9C917A1" modified="2014-03-19" version="1">MYSPPSSPSVLASTSRHNIIPPRSNANEQRRQKSLRLFLGDQSDEDTTSDHDYDLGCHSDADSDADNGPSTSTFRLQAGPAAAAFLGSPQRKTARPRAYDDEEEGARTLFFPRAQARQQKQAASPRKSSVSASTASKQMTANSAAIPTTPTKRQKGFVVRGNVTPSRAFSIFKAVKQRSQQRQQHGLPTPPATSPLRPIILDSCDDSPRHMLASPSQHQQRHRDLFLPSSSPKSASRSQLQQMESPSRRSLTAASGHTLPQYKPSAFSEGAGNAPTLSNSLFSLRTRQGLHSGHGLLSNARHFSAARTPILDSTPYLETFVSPASCQFQNPRTADEEILSHPISAAYSYSSRSVNPSAQWLAVGDDEGRITLLNTLPWQDPAAECFAGNPQWQASTSAAIFEVVWRFDDRSLLSGASDFSIRSWDTEYQKCTAEFEGHGGSPRTIVYDPTTNGDGGCGMVFASAGRDGTIRIWDARTSSRAQTPGLDEDSDSVGVRPVLTINAAHATTWENNSMASKGRKHARSGAVVGARGKKRTQQSLPAGVTALSYLPDGQGHKLLSGGSANGIIKCWDLRHVGQSHEATPVARVDTAPASLGKRGADLPADAPISAGWQTPDLSMLGPSPSVGLRSSHGLSQIVSSSTSLFASCTGGKIYALPLSTFLDSHLVASGVQTLYEPVQCQNTLFSRMALFDDRFLAVGCNTGNIALWDVRLDRTNQMGQPQRAAEKDLFEEREYAQCEELGFAHRSTHAGGMTVLTEGHQRNTEVNAVSWANGPNGPTLSSVGDDTFIRTWYPDRDLRHTIASAEATRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMS7</accession>
    <name>W3VMS7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMS7"/>
    <dbReference type="HOGENOM" id="CLU_029212_0_0_1"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="6">
        <location>
            <begin position="59"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="7">
        <location>
            <begin position="376"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="663" mass="71764" checksum="D2416E0621184FDC" modified="2014-03-19" version="1">MTVDDAQAERLVGQAAAAARLTSTTRTDIQSLYTQALDRRAEEDGERDARYTALAPTLVALSQQASTSKQLLGSLESFLSTFQSDLSTLSTHISALQATSHQIDSQLDATRDVELQLAAFLSDIALSPRIVDLFFDTDPESRPELWLKAVGQLERVLDATLPSATIELPGRKEPLVLGDVQAVREVRDVAEACKNVVAAKLRTYLTAPHAAIKASVTTNLQVVQTSVLLRQHRPLYGFLARQMPRVAIDVQRSYVGAARLYFETAFRRYTRSLGVIRKRWVETSTAATITEPPPAGADASANARAMSNALQASMSGVSKSAAVGMRAGGSTPTRGASQDSSAGDADAVSVDAWLFPASRLAYSRLDSGAATVLGYLADDSAFKACPENLFRSLSLVLVDNVCSEYTFIVRFFEAISSDDDRLLDPRPVGETPGVASVDSASAVEEDEVEASVVQLSRHEQAQLRGRGASEEVFRQIMEPAVTTWTTFIKSLLPSSSLTVSAYFALLSMVQLNDALLALVASRGCDNSLVTSAMMGFKLDSYPHLKRFLDDQITALTNPSQSASLWKTISMSTTSTADPQIIAVRYTSLFTKSLWILQNDDPAILSALQRLRAQLAQSLPTTPPLRDQAINILISSLESALPPSLASHPTAQNEFAFWNNILRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMX5</accession>
    <name>W3VMX5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMX5"/>
    <dbReference type="HOGENOM" id="CLU_029507_3_2_1"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="49"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="226" mass="24952" checksum="279DE3B5DA534A05" modified="2014-03-19" version="1">MRSSGLSLVNSELVATLLLTRSSPAEASIRLAHSPAQLGTVRSFHHTTSITLPSLAAFTLTPIANMVSFYELKAKKPSQEDYNFDQLKGKVVLVVNTASKCGYTPQFAELEELNKKYADQGLQILGFPCNQFAGQDPENDDKIGEFCQRNYGVTFPMMAKSDVNGSNTNEVFQFLKKEKSGILGTEMIKWNFTKFLVDKNGKVIERYGSNTKPSAIAPTIEKLLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN42</accession>
    <name>W3VN42_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02754</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN42"/>
    <dbReference type="HOGENOM" id="CLU_007946_3_6_1"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="661"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="693" mass="72609" checksum="380BD835BE90ED53" modified="2014-03-19" version="1">MSADPVGAAIALAGVPDEPASLHSSALRPSVDSGAGNASKAKASSDSIPLPEEDQDEDDFVVFEDRNTLPAPHLARGELDDVAASQDDLRRPSGEDQGGSRFKSLARASVESLSFGYRDHLLPLSLSGGADDTLAGDYGDVESSVSAAGASGSGRRNASRSQSRRHTRNYSRDRVAERRVTLIDGIALTIGVQIGSGIFSSPGVVTLNTGSIGASIVIWLLSGLLAWSGASSFAELGASIPLNGGSQAYLNYSFGPLSAFLYTWSALTALKPGAGAIIATIFGEYVARILFHATGKATDHPHETGLDGIPAWSIKLLAIAIAALITAAHAFSNKLGTRTQIATTVVKLLALTAVPILAIVQAARGKTSPSSQQAFSSLANLFEGSATSPSSYALALYSGLWAFDGWDQSCFVAGEMKRVEKDLPRVIHISLATVILIFLSAVVSYFVVLPAELVKRTNTVALDFGSAIFGTVGGIVFAFLVAFSCFGALNGQIYTTARLIMAASREGYLPEKLGQVNRRTGTPVAALALQLVLIAAFVLFGSGFASLVNFYGVCSWAFYLASVLGLLVLRIKEPNLVRPYKTFLGTPILFAAVALFLLLMPIGSAPLEGLAALLFIAAGVPVYYLTQASAGWTASNPILAKLRASLGGNRAGDVYDGRGQHVPLATSDANDPNDDEEHIEMLPSSPEPKRDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN63</accession>
    <name>W3VN63_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN63"/>
    <dbReference type="HOGENOM" id="CLU_883167_0_0_1"/>
    <dbReference type="OrthoDB" id="2552843at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="339" mass="35087" checksum="742D4B17A5DA96EB" modified="2014-03-19" version="1">MPSFTLSPSKPAKFSDANGKYTRIESGKIPSRGRSLGATRRGKYSLAVAAAAASQASYSAGAGSSGDDDDLHAASVVEPASTRRRARGKKGKTLDEVAATAGRRSVAMIMDDTTAPPSTTPGVQDDTSAAPSSASLFVSHVQGIIALIGVIVLLILVRFAKISVDNATYVRGVLNMLTGLAATASAHKLSMTVAVSSLASIRSVESGKSKPPSTAVTVAAMGLNPSQAFNLIFGSDQFFQIVSFIEAICSAIASYMAGSSIVTSTTEFTKNGTALLELDISQAATLWGICGLWIVALALHATTAFANKSTIQTVQVASQESMREIVAVMHTESVYSGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNK2</accession>
    <name>W3VNK2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNK2"/>
    <dbReference type="HOGENOM" id="CLU_031002_0_2_1"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="407" mass="44116" checksum="11BA8D7B0AB46DD2" modified="2014-03-19" version="1">MSKKYDVVVFGATGFTGQLVCKYLLSHPEQRPWAVAGRSASRLASLKKSLNLPDTVGVIEAETAKYDTLTAMTSQARVLINIVGPYRPFNAVAVVRACLESSTHYVDLSGETGFNSDCISQFHADAQAKGVVIANSVGFDSLPFDLSTFLAAQKARQLSGKDVALAECAYELPKDLSAGTLASAVSMASEKQQMFAVRGDWLSPISKPHSLDFASPVRWFEQRRKWGAQNTFSIHNTRTVTRTWGLLQHHSSPSAYGSTFAYKEGTLLPNRIVAYIVAYVGVVSIWVLMNIAPIRELIARSMKPNSGPSEHSLVNSRLRVDTLATATDGTKAICKMSAKGHPGYLLTARMITEAALTILATSDRALPGVKGGVLTPALLGADTLADRLSQFAHFDIRTEAYEDAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNK6</accession>
    <name>W3VNK6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002459_2_1_1"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.970.30:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit eIF-4F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MI" evidence="9">
        <location>
            <begin position="1418"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="868"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1252"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1254"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1345"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1558" mass="164651" checksum="35DAA1780AE92253" modified="2014-03-19" version="1">MSSESHPAGNNSNVAAAGPNGDATAANSRRQSAVSLPKGAAANPRPAAAINFGSVHDQNAMLSSSPAAQPSSGQHLHGEKPTVFGSVAAQDPQSKKTTIGFAGGKPDAAPANGAASSKSMDFQKLFQGSGSPAPSQAAASNASGSPSPSNAAPASTAPSTPQPNSGSQSQQAGRPHASSNLRPPAGTPHHPGARPFEPQRSPSAHQAQGSRIASQAPPHQQFHGHPQGAPQQPRSPHMANAVPMQPMQPMGGPWQHQQPMAYAPPQYGYHPGYGYSPVPQHWAGQQPGYEMPGTPRSPRHANLGASPMGPNGLPGTPSMAPSTPLSARGANVPPSPSTAHSNVSSPAHQPMTLGQQQASRPPTFSPAASYHSPSHSFSNPMSPAARQFEPTQKRQSAAIRIVNPETQAAVDLQSIQKTPAASQKSTAPASATSSPSISRASPAIVQPAQSKPIRMETPEAFMARVQASKEEAARKKAEQESGSKDAAAAADKKQDDDDKQAKEAADAKKKADDDAAAAKEAAAKREAEEKAAAERKAAEEAEAKAKAEAEQKEREAKEKADAEAKAKAEAEAEAQRKAEEAKKAEEAEEEAAKSKADAAAETKTAADESKPKPAPIDTEKAARSSVADVERMAREASSVPPSSQDAPKTPGLPQTPRTPGTPGFAGLPAKPLSTIGSAAASNGNGIKLDGEALEKKKKTVTTTDAASSPSQPSNKDKEEGSSSGASASLVAAKFIDSFSKVNYPTNINSPKPELNQSAEPGKFRYDRDFLMQFMGVYTEKPIDLPPLASIGMESGGMGAGRLNRRASAMGPPAAPGRAQGLGISGSSGFGGKGGIGSFSHPAKTSEERFAAASGARASGMGAFGPMGSFNAGARSQPLSRTGSGSTALPSRDMMGTGIPNGGRTKSNRGRQRDPNSSRGPQVNPPEKGGPTIPLDQVVPLANSENRWSRGASQVKADSPEMVQRKVKGLLNKLTLEKFDSISNQILEWANKSVSEDDGRTLRQVIQLIFEKATDEAAWSEMYARLCRKLMEEVSPEVKDESLRTTDGKPVVGGSLFRKYLLNRCQEDFERGWAQRDTAIAAAKSKEAEDKAKKDSNDKAEAEAKAAEERGEKPSDAPKEAELLSDEYYEAQKAKRRGLGLVRFIGELFKLSMLTERIMHVCIKKLLANATDPEEEEIESLCKLMTTVGKLLDSEKARGHMDIYFQRMNEMSKNEVSINSRMRFMLKDVIELRESRWVPRHDNSAPKTIAQIHADAARQKQQQDAENAMRARGGPISRGGSKRGQARDNGPDGWSTVGGVAPPPRPGKAGDLSHFGKIERGTSGRPLSFGPSTMLGRKNQGKGSEDGSQPPTRTSSQTNMFSLLNQAGEGDAAPSEEPQRPKLNLAPRTKPLPGNDGDKEGENDGEEDAGKAADMSDEEAKRKIANDIKEFLEIKDVNEGVEAFNTLPASRQAEFVDKIVGTAIEKKKEDVANVAALFAKLSQDGHLDEESAFKGFEPHMEFLDDASIDIPAIYSFVADLLVAANVTQEKIEELAGKIEGDGLKTPKDKLLEKVAAARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNQ2</accession>
    <name>W3VNQ2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNQ2"/>
    <dbReference type="HOGENOM" id="CLU_033579_0_0_1"/>
    <dbReference type="OrthoDB" id="2549796at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="576" mass="62711" checksum="08A36FC72A34EA00" modified="2014-03-19" version="1">MAIIASPELAMLQSDTLHATTPSASAMQAEIIFNVLPPSAGKSFMVLLIIMCLCLGAVVMELFNHIRFDINLIRKSGWSQPAKLVSRLAYLSCRYLSVVCLTLVVLFLSLKFDDCKAMPEAFNILGMILLDSVSLVFVQRTMALYSWKAKIVTPLTLYYCVVLAAAAVCIPFYGVGYRIPGTEFCAYDTRRHLTRTLVANVVYKSLSMGLDVIMLLLTLHRLIDGGLKAILNKKPQQLYSGLNDRSLSSFLIRQGFHFYVLQLGTDIFFVSTYFSLTEPSYQVLGTALVFCVPPIAAAAAFREMGKKASLITQRNGSKVNEIMNSTGSPSGDNSAAARGTRGLRGSAAAISGANHGAESAVDPSAAGVNSFVLQARSNPGNGSAQPEKTTRISWGGRRNFTRSRNDPTEVDNGILVTIGTVSRSEEVEEQWDAGSPRYSSDNPDPDTLEMQRQWPRLAIKSPNPGSEAAHRSSEGHSSSEKVDPDGVGFEPVQVPTLARRPTGGNHAYPPHLAPAVEAGSPWIPQTPESPYPATLLSPRQFSRNQSMSDASRANSFSRQQQQQQPLDEDDSPWRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP54</accession>
    <name>W3VP54_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP54"/>
    <dbReference type="HOGENOM" id="CLU_2050638_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="120" mass="12140" checksum="EC3DC642EC5E2766" modified="2014-03-19" version="1">MPTQLEAKRLSAAFSAATEALTTWFSAYAAASGSWQLSTGSSDDSFALADTSRGHLDRPRDDRPPHGSGLKSAAAVAAGHSTSDGSPAASPTGDAASAGASPALQHAQIIQSSLRDRSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP62</accession>
    <name>W3VP62_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP62"/>
    <dbReference type="HOGENOM" id="CLU_064784_0_0_1"/>
    <dbReference type="OrthoDB" id="2556282at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="365" mass="37853" checksum="B34A1E1B85FB3EF9" modified="2014-03-19" version="1">MTAGCSAATPASGSSSSQLATPSTAAPLAHLRLGRRSRRSSSSGASSSSSTSSSAAPSGSLGLRARSHGRKRRRHSTLSSSGVASGSDDDERAPPTVRLRLGSYVSEFRIAGSRSSSPGTGRSTSPLLPRQRHQLSIHTMAPTPLSEAVGSAAADDDQDDGADADVDMDLEVQSTFQAMQVDSPIASPSLSSAASFFSRLDALPNAPPPNLVSGATAGVLAPLLIEPRYATPSRSPVQTNLALPSISALATATTVQPGMFPSASLIAARRNSRSSLGLQQHQPASPSPLSRMQPQQFANLNPFASHMYHHPHQHPAPSSQIPNRTRSSSTPPSPRSSQPDGAQRQMPPSPARRHSDGTPTHPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPC7</accession>
    <name>W3VPC7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPC7"/>
    <dbReference type="HOGENOM" id="CLU_1235487_0_0_1"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="107"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="225" mass="24313" checksum="96A0444D99B70987" modified="2014-03-19" version="1">MPAPLPKNLQEATQDAVDMTRHLVESPGYSSSAVDSTVTIISIERTGLDENGELVSEAADVDDSQETVRLTMKTAGKATAPTPVRNDIHARLVLRMRVPERLNNNLGNMHGGCGATLVDCVTSMAIYYHTSGVAGSPWSFLGVSQNINVFYLNACPVNSVIEMEVYTASVGKTIALIAADFWLVERADGQEDDGEGPVHEGKWKRTKKTISGTHTKVDNSARLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPF0</accession>
    <name>W3VPF0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPF0"/>
    <dbReference type="HOGENOM" id="CLU_040063_3_0_1"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="161"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="439" mass="48599" checksum="7BB08FBA97262BD5" modified="2014-03-19" version="1">MPGKPEASSSADANKPASGSFKHVGNKIKRTELYRKYKAEKRKSKLARRSAQAKEERGEDGAAKKAARLAANKTRTIENTRDFNPTIINAPNTHEGPGPSNLGKKKADEADDSNEDDEEGDVEEEVQEQEAAEEIDDDEDPSAPPAILITTSMPSSSTSPHLESLNARSHPSERTREFVDELLSVFPGAEYRPRAKAQGVGLGKICGWARERRYDAVLVVGESRKEPFALTVIQLPHGPTAFFRLTSISTGAEIYAKARPTPHTPELILNNFTTVLGHRVGKVMQGLFPKIPQLEGRQVVTCHNQRDYIFFRRHRYMFKSDSKTALQEIGPRFTLKLHSLKESLPKGAGVWDGKYTAEYAELEPEELEAMQSADADAEAEAAAHDEAGQQHGSSTGNDPQAQTASASSKKKRQRGEEDTTGLDFQWRPKMSVSRRNFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPG1</accession>
    <name>W3VPG1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPG1"/>
    <dbReference type="HOGENOM" id="CLU_1993583_0_0_1"/>
    <dbReference type="OrthoDB" id="10419050at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="125" mass="13418" checksum="06B302091873EBF8" modified="2014-03-19" version="1">MQFDTKSIALVKNSSITLAVGFGLAASYWRSLPLLAFGLLTIAFVPLSIAAANEPRPSDPCPACTGWSVAQYIVLDSDGNCATQCQPFIVFVRSNLVTAGIISASIVALHKLVSDYIEGRQRRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPN9</accession>
    <name>W3VPN9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPN9"/>
    <dbReference type="HOGENOM" id="CLU_452777_0_0_1"/>
    <dbReference type="OrthoDB" id="4850at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948:SF1">
        <property type="entry name" value="BLL5189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948">
        <property type="entry name" value="ZGC:113208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834773" evidence="2">
        <location>
            <begin position="27"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="603" mass="67032" checksum="78501D7934226962" modified="2014-03-19" version="1">MTSKGLASLGIWQPGLWAGFLPSAWGIPYTSLHAVPIFCCPLIAVPTQPANCRYIRAKRDRSRLPSVPTLLASPFMRACLEALGWGLASDGGEPAISHGRAHNCNVERFPGLRPFVIDGKRVSRSRARVLVCGGAFSGPLSRRWRKGGPKISSGSSDGWLLASKMNARFALDLHLTSVPTAYSQALEFRKESTHPTSRSVGKMADAEQDYEAIRQENIRKNAELMLSLGLDSASTRLRSPSPERKAPAAMRRTNSTSTPGAADPGSARKSSRIASGSRPRSYREKDLLSSFKRPTQKKEKKVRQGTRKSSRASTSSRTKYTDWNSDEDDDSDAYVPRWRGGSASAQQNGHANAGSDDDDSDEANSSRGSRTFDLSGRPILNKLSNPSAPPLPSSGGDEIYEERMPLPTRKHVAKGKGRGELVFEPEFSSFTPNVTPEEMLRGGAFGGTAFRDYYSRVLQRPIDVEAELKELPQEWLAGLDVDDMLRRDDLDPSRNKFKVKAGQSLEEWEKAGWIRPLDPRGWFQWYYRFYLGRRSADDARQIGRWLKACGPGGRFRKSLAVNVATKGGGRWDDPTVNSVVRQTLWQWGYELTEKHYNEYLDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPP2</accession>
    <name>W3VPP2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPP2"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="42"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="467" mass="48115" checksum="18916F279400AE2B" modified="2014-03-19" version="1">MAPVAVTEAAPVSALATKLNGTSVEMNGAASFGPNTSAVLHGAKDLRIEERAYVAPSGDEVQVRVRATGLCGSDLHYYLHGRNGDFALQHPMCLGHESAGEIVALGPDVPAATGLAVGDRVAIEAGRFCGSCGKCRDGRYNLCKQMRFASSAKTFPHLDGTLQKYMNWPSWLVHKLPANVSLTSAALCEPLSVVLQGIRRSQLQPGQSVLVYGAGAVGLLACAAAKASGAGFVAAVDIDAGRLEFAAANGWADATYLLPRAPPAETNGSTQELDARARRTAEDKAAISSASSSAQTLLSSLSTPKTSSTGYPVQPAPLDLQSDGFDVVFECTGVPACVQTGIFATKAGGKMVLIGMGNPIQTLPIGSASLREVDIVGVFRYANTYPTALALLAGGTLRAQGGGLHAQATPTDSTEGKGSAKKMGGIENLVSHAYPLAESATAFQTLANGKDANGRGVVKVFITDDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPR3</accession>
    <name>W3VPR3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPR3"/>
    <dbReference type="HOGENOM" id="CLU_1787649_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="145" mass="15529" checksum="6BFDB4BF86414EB3" modified="2014-03-19" version="1">MEEPAWTDIPWVSNGPDNVYLVRQTEEPTWADFSFAYNGPDLDCLVRQTQQLEEGRQATGPPQSNAPRGGSLFDFIFGAVNEDTTMHSAGNGDAPAGNQAVHESARGTTNAHAVGVASGSHQSKASVSKDRRAKDKAKKAGGHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ09</accession>
    <name>W3VQ09_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ09"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_0_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="213" mass="23265" checksum="498319CE40CCBE91" modified="2014-03-19" version="1">MAAESNYDYLFKVVLIGDSGTGKSNLLSRFTRNEFSLESKSTIGVEFATRSISVDGKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHPTYVNVSRWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEAKAFAAENNLSFIETSALDASNVEQAFQNILTEIYRIVSNKALQSSDDVIKPSGGETITVQPSADDGGATKKNGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQI4</accession>
    <name>W3VQI4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQI4"/>
    <dbReference type="HOGENOM" id="CLU_035932_0_0_1"/>
    <dbReference type="OrthoDB" id="3356264at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="528" mass="55232" checksum="B74A667AD4B76A81" modified="2014-03-19" version="1">MAPLKVSSLQGSALDGPDPLPVVSTYTLYFGNNGATVSAPVASMTAVPTTTSTPTSAKSTAGTTESTSEPAKSQCSKKHTTARVSGASAPAATGASGSVGKKNSSSASSSTATSVSQQNTVFPTVAPASPTAASQRLLNNGSQVAPHNLINRVDNLVKTFHGITGRKARQVALILNNQTNVVANASRTEAILSHLAEAYPSNSTALLNPTAPMQTVPITDSSDAAVGAQKTVHEFVMQAGRSNITLLSNVAGYGPSQVRHDLHVIRAWAGDLNQLNTPALLDETVAAIMSAAARYFPELSTQDAARVIMADIKAESDFDTNNVSGGRLDSGSSWGLMQVSPLGSGELKLFQQHATVTKNTYSWSQAYNVTTTPTTFGAGALLDWDTGKTLQIKTLTNEDLFRPWVNVHVATWIQSNLARTSSQDPYTWPQVYAASNAARGGSNDRKAWSAVDQVLVGSGLPRSFLTALGSWVAGPAVDGFGSYTQQGDDVSAPYFKNIAQGLSVLYGKTIASSWLSSLTLHAGLVDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQN3</accession>
    <name>W3VQN3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQN3"/>
    <dbReference type="HOGENOM" id="CLU_003661_0_0_1"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="8"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="810"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="489"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1040"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1072" mass="115063" checksum="0616934240A25B7B" modified="2014-03-19" version="1">MSDAHQSPLLLFPLKSTEEVDLGSAVRSLIANSYGEEPKKYAEQTSQLNRARQDAVRGAASDATGRDLLFKWFHMLEMLELRFPELRVPFPWKDAFTQKAISQSSLAYEKASIIFNIAATLSSLASSQPRMPGNAEGLKRAYTALRQAAGMLSYINENFLHAPSTDMSKDVVKCLVGITLAQASEVFLEKTIEEKKGPGLIAKLASQTATAYTALVEDSREHLTKGIFERSWTYLIQVKAKHFTSVMHYYKALADDAAGSHGACLVRLTVAETAAKEARNLLTTFSAAAAATATADRPSLPTDAGSALTAVVNAQVTRCAERKETAVKDNDLIYHDILPSESSLPAVDKLVAATPIAIQEIFAAPEVQRVIGPDLFQNLVPLGVHEKASLYSEEKAKIARAESERHDIATGELQATLEYLGLPGSLKKYRAIAQGSGSGAMLDSLADPGAEVMRWSNEEAEGGGGRGADGLGVGAAGIDSALNRIESIKTQAAKTIDDALAELDNENRECEKQRVRFGHKWSQEPSLKQTKDMRQSLRENKEAMQQASQNDAQIGELWRSIRSDIQLLVSGRDALEGAFAAALTGQTGLYGGAGAQTSLIDVSADEEQASEADVAAVKAKLSQIDEALTKLNKIKKERSEVLADLKEKIQTDDISQVLVLNRRAQNVDASIFAAELEKFKPHQNRIAVSLHHQQALLGEIETAFKELSELPASKAAGARWDEKEKARNQLVARLRRARDSNAQVRAGVAKGVQFYSDLEEIVRETKSRVNRFCTDRRTERTRLASELEWEEKGSDTRAAAGSADRLASSMAGLSGLGQPSGAGGPPPPPPPHRQTSYGGSYPAGPQEVRSPGPPPPPLPQQQSYQQAPAGGASAHDPYQSMFSTGPFGDTRASPAPPVAQQRGTPYGQLGYGSEAHAQPPRAASGGLPPPPQQFQASFSPAPTSPSQARYTSPPPPPPAQHSYGQHPPQHGGYGQAPPSGPGYGGYGQQEYASPPPQSPSHYGGYGAQNAGYGQHGQGYGQPPPPQPQHQGYGAPQHGYAPPPNANRPPPPPPQQGQYQQQHGGYGSYQPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQV7</accession>
    <name>W3VQV7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02286</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQV7"/>
    <dbReference type="HOGENOM" id="CLU_087811_3_0_1"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="16875" checksum="B7A2119E9FB4482F" modified="2014-03-19" version="1">MSHADHTRDPCPWVILNDFGGAFAMGAVGGTIWHGIKGARNSPRGERLPGSLSAIKARAPVLGGNFGVWGGMFSSFDCAVKGIRQKEDPWNAIIAGFMTGGGLAIRSGPKTAVGSGIMCGILLGVFEGVGVLMQRFMAEGNKQVAPIIPDTLPGSAPPALSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQW4</accession>
    <name>W3VQW4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQW4"/>
    <dbReference type="HOGENOM" id="CLU_611282_0_0_1"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="526" mass="55722" checksum="A969C0F87CDB0924" modified="2014-03-19" version="1">MVVEEGASARCSFLADTSDLPPRTPRQFAGRVEFDLHTNTNTAAPTSFLALYNNTQRQAQPTGALGIDVGHTFLSIVLRCATMAAAGADETGLTRVVAFGSNLFCQLRPDSLEEGKAAFAGATISIEDAASVVAVCTSQTVYRTHTGGIHVLGDGAQLLQDLLRALPNPSAAVFVGQDVFEVVLEHNTGACHFLDYEAQEALTVTCAAPVWKTAVADGRGRCMALDVDGCAYLFSSIAALRHATEASREATTLRELSRFVAYTYNQVKPAQADSSLPRFVAVAAGNAHFVLLADQAVRTEAPVWVYGDARFGAVPTHPDTDTALVGAIRAQLDTSPTADVTDGRLLQALPTFSRAEGFPCRIGAIAAGGRHSLALSEHGDVYGWGWNEHANLKPIAPCSSTEVPAWHRNMLADPTPLDMPELNGHDVCIANIAGAEGRTLAVSTDGTLLVAGCNQDGALGLDRAALGGVPRKPRFERSFSQIKSPFECVNGVQAHPGWTRRKVVSVHATALATFVTVDSSMDEARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR19</accession>
    <name>W3VR19_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="12">ITPase</shortName>
            <shortName evidence="12">Inosine triphosphatase</shortName>
            <ecNumber evidence="12">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="12">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03013</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="12"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR19"/>
    <dbReference type="HOGENOM" id="CLU_082080_1_1_1"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="196" mass="21454" checksum="A5899AE8F849F2AF" modified="2014-03-19" version="1">MSKPTLTFVTGNANKLREVQQIFALSPNFPYELTNRDLDLPEIQGTTRDVAQAKCSAAAKALGGPCITEDTALGFRALGGLPGPYIKDFMKTIGHDGLNKMLDGFEDRTADAICTFAYCPGPDQPVQLFEGKTEGVIVPPRGPTYFGWDPILEIKGTGLTYAEMEPKQKNTLSHRYKALALLQEYLVQLSDAPKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR75</accession>
    <name>W3VR75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01568</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256504_0_0_1"/>
    <dbReference type="OrthoDB" id="192663at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000001">
        <property type="entry name" value="L-serine ammonia-lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051318">
        <property type="entry name" value="Fe-S_L-Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182">
        <property type="entry name" value="L-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182:SF1">
        <property type="entry name" value="L-SERINE DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834519" description="RING-type domain-containing protein" evidence="12">
        <location>
            <begin position="41"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="541"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="315"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="629"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="955"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="974"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1368" mass="145342" checksum="ADE50926A7B20A7A" modified="2014-03-19" version="1">MLPSLALSSSSLDQFRKNVYRPRLCLLLLLVLLSPHNTSQLASPDASTPDTSISQPAQPAQPSWGLSVIDGLVIAAPPPASQLLSALSPTAPQSESALPIGASHPSPAPSQSATHGDGAAPSTQQGQPPPGSLFRFPKLSWGLLVDEHVLPALVTLHLLWAIRLAGMAVEDGAIKNSLLGAKSPFYAVTLPVLYLGVLSCLALLAGLPVTMAAIGARCLVWREALGFAPLRTVAVDRKSSFRADGLLPASLFVMLEMASTLVHLLSVLPKIDASPFSHMLPAQLRLPSPSHMPPLVELLPLPQFIKAALAESATMPPSSRYAGRRRPMMPPLRSAAPTAADTSAAQHQAPQQQPTSATSADAVPSPAGEPTARQTYRRVGAPEDEVISSPSVTRPIAPLTLPENDATEPGSSPSASRRRRAPRLRGQSVLVSTKWFSDTATALFDKAMGALIYSVITLRLPTLSPTSLPPVLSLLSLRSELASLTQVWTRARSSVECLEFVRRRWGVQLERAQDPYTSVVRSRASAAAGDYKWKSYDDVYCAICFEMTRPKADADSIPETSGDSEDGNASQHANRFEFCRLDCGHELHDVCLVSWLTAQAFCPTCHVVLSFSPPAIGPSYAIAPRRKTHIEADGHHHPKRRRDKLDRHREPRTASHAARSRSTTCAANSRSSTALQHGMTALPAARLVQAPRRTMHTSHCRASSAAASADNVATSEASETEHAVISTFDLFSVGIGPSSSHTVGPMRAGVIFVSDLADMGLLERVHTIKINLYGSLALTGAGHMTPQALLGGLEGDDCETVDPPSVPVRFEEIKKAKQIHLGKNLFKTLGANANGKPVTKGKLIHFDYDRDLKWMFGQVLPHHSNGIRMSVFDEQGEMLATNDYYSVGGGFVVNGALATPSSSALSARSSSTQAPAQDPTAAAPLHDETIELSAHPIDWGENVFYKQIRRKDAEDGRRAGSAPVVEGLLPQVEAPTPAADSTSSALATTSRETPAHEPEKLTARASSGPPFPYHNAASLLRQCKTRNLTIAQVVYENELTWNPPEVVHEKLVKIWTTMDECIRAGVESTEHTLPGPLAVRRRAPSLYARLLRGLYRGASLPAGGSPLSGAARSVSGEGPGGIDSPPPRASTDMVSQIGATGLTRTRMIGSFNHPVMPCPPRRTNFPAIDYLTCYAIATNEQNAAGGRIVTAPTNGAAGVLPSVLKYCFEFIFDDDPVRDLENFLLTAAAIGMLFKRGATLSAAEGGCMAEVGVATAMAAAGFVAVLGGSPEKVLQASVIGIEHNLGLTCDPLNGQVQIPCIERNALGAVKAVTAAQLALAGDGKHSVSLDDAITAMRETARDMHTSYKETSLAGLATAVKVPVAIPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRB3</accession>
    <name>W3VRB3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRB3"/>
    <dbReference type="HOGENOM" id="CLU_006498_0_0_1"/>
    <dbReference type="OrthoDB" id="2555981at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="930" mass="98819" checksum="4276EE00A2B7DC66" modified="2014-03-19" version="1">MSASPFDLRMPRLEGHLILNTATLSDSPQTSDRTAWSEKWCSLEDGCLLVYHDRTAAIVMPDEPICTIDLRSFAHVQPAPPHTDALCNLVISCTPLEPPKSSRLFRPKSAMSLNRLQSDSVPRDPPDQEPRPSLASSSGRVSFQALRSGAHTPVAMSTNFEPRTRTSSSHSNSWAKLRSGSRKLYAKVSSSSSASFRTDSPAALASSASSVASIADSSDLTDMTSSGAPSPRTPILSNFGQGLERVYLRTMSEEDLDSWLEALSRSIRLLQEADGVPVHLLLPKKRVSSRPSLGNLPGFRTPASLSNSPLLPSMEQGAASTIDDTTPKPTRKRVASSSSLGLALASSRALQQAASGRPKDVHTASTLPSWTAESTGAGNALPMGPPDTMQLRSNLKHKRSISTTSSSLSLSGSSQFMSTRRNSISSTRLLSSSVSVTRPATACAYSASFAQPMREGSGEATTSRLTEPSSAATMAAETTVPTRHRRSGSILGFGSARIKAWRDNSSTSEASATQARPVGLGLEMDGQDHARDSSEAHRHEPSKGLSKLKSFRLLPKGTSSVQETGRMSASASEYGSFQDRGAGHPDSAYETSAKKSRGMTRTSSLLSLTRHTFSSLRPRARPSVKQTFASRNADESVHDVQVDASMRVEPAEGDFSYELLAPAQADCTADSTSPSLQSHCAVVASSRTTSRAGARPLLAREACVAAPAELASDYSEISLNRMDGDTSECLATPPLPLERILPPEQMIHAFDQLRAEGAARSSRSSNSNWLGRMETPTRRGSVDWAAACAGRERTLRGAASQTFAVRGSSMDLQALARAGATGPRLRTSTSAWDLAAVKGGRAEASPVARAESLEEVQDENVQSLPAPPRASKRRALVSTGAAASPRPRPAPLGDRTNALQVVGLPDVGELCIDDRRPAARGRRAQGAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRH7</accession>
    <name>W3VRH7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235431_0_0_1"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="1170"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1480"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1645"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1911"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2015"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="904"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1679"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1731"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1913"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1938"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1969"/>
            <end position="1981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2048" mass="216636" checksum="22270D487152DEA7" modified="2014-03-19" version="1">MVSDQASRVSSSQREPQRGPEAIANFFGGRYSTDQGSVRAKNTESSLSSYAGSMRRSSSGTEFYSQAHSANGADGADESSAASASNAPASPKPPRVYSSFSAAAAAASRSSVNKKSSQSSIPSNSAASPSIRQSPAMASPRISTSAFGGDVTSSSGVNADSEYASPSKAAKPSGFDVASVNQYTPGSLASTFPWLSSNPQSSSTHLVSRDRVLAPAQSSAQLQSHMDSPPNVSQYSKGKGFGWNPNDQHRAPPKSASRLRTTTNTPRSEMRDTKDSIGRGLGFKSTSELDLPERMRSQRKAALAPPRLSQDPIAISIEDELRPQPGVAKTDSAFSRLGRAFRRKSKTGSDLRVDLGSDAPPLPKTPRRMPSQMLATSQLDRLAPNASSTTSSLTADAVMQRHKRSVDINGARAELQAPPKDAPQDSQSASKGSDHPSPSSQTKSRGATRNSADLLSSQVDGNRRNASFDSRPVEGATSRVGVQEDRAEEGPRTDQPRSLADASAAPADSRSNEAEARLTRTNHRTHPDIAAEGSKSPEDRQQNRPAVDGSNRAEDPQALDRSDDAQPGDRAASAADARPLSMESTSSSARRNSLVFLASAISMGAIAAEPQEAASAADAKTSNIETDKSEKASDRGPLTDTAASSVPAQTDTFVRSDNNASVPTSSEHHTSASMTRVQSGSSDRRRLEPKSAVRSDAVPSILSDFLSMDAALSAKDGNKRKAKEPTGSSRKAKSTTESSSALERTASANSDGKKSSYSTSPKSSRATKGVFMSPPAGPSMGGFVSPFYVAPLTSVDAGLANRATRPTGRRASASSRSTHSDDSKSVHSTTRRGSASQAPPAASQREAQEAPQSSRATEETVIKSQELASAEKARKVKSVGNLKASAPEQSQEAMPRSSTSKIPSASAVSDAPASRSHGVSAEGANAATQAAEENSNDSSLSRSQSISQRLLRRPKTSGAEAGLGSGRTTLADAGLQSSSRRGSGPGRASLDESGRSGKPLSSSPTETDFEMLASSDLSATASKDTSASRTSRENGLAPRASNAWLKESPASGRRPSESSSGAITPSSSRIESSGGAAALFGNPTTRPRTSSLLPSFGFSRSRTGSSAGLEGTGKSAGTFGGSSRSASGGLWRDQADAGTRGGAADSSSQLQDVNGTTRSPRASSSSRPSFSRQLSSTTAGLAETESAQSSVKTEKKFSLSAYLPYDDEDAPEYADRIASTAPKTQLAAILASSPDAFYIDALHHFMTRFWFNGLPLDIALRKLLMDLHLPKETQQIDRVMEAFAKRYNECNSGLFASDDQPYILSFSLMMLHTDAFNKNAKNKMTKVDYLRNTGSSGVPTEILEYLYDNLTFTQFIYVEDEEGARRRPSEASGISTVGPALSSSLAAQGAAANARTKIDPYFLITQGRLGELRPDLEHLIPEDTPFSYTGTLPAFDVDRLNSAFLHAPSIEIVTTKPPSDLAAAANASAAAGEEEVVSLKVTKVGIVNRKDDVSDGGKKAASRKWKTSGLLLTGSQLLLFKDVVWINALQSQILDQVGHTLLCNGIPTDDPTAVDEVEGGVVISPRITYFRPDGVISLADAVAVKDHSYGKYDFVFRLLAAKGRQYLVQAQSEDDMNDWIHKINFCASFRTCNIKIRGLDLAPRAGSGTGLADPDSLDVGDPSNGRSGRGAVSRLSLSDSDRASRGIERDGSGRSTPVPDEAGDTSREASFRLSVDPMSRTSESDGPPRPASSASQRMSPASSALQKRAKARRELMLTKIAETEVQLERASTRLADEIRLARHFAILTPFLKSTRERIEMSAQPLAHRIRSLRLEVSKAESRCKMLRLDLAAGERVARALLPAVYLSASAMRSANRLPSSQVRTPQLLELGRLSESQAQFEDLFAPAASNGSAAGSSDAAAALAVANKVTKPASHQRNQMNLNAVTEQPADESPVIATRRELPAEDAADERGADVAASGGRKQRPPSPAQSVASQSSAENQQGRERDRSRRRTHGADVPTTDEVPEDWDLSQVARPGTNRISLVDLPSPDELQEATGGRFRFGVRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRK0</accession>
    <name>W3VRK0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRK0"/>
    <dbReference type="HOGENOM" id="CLU_017661_0_1_1"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="362" mass="39199" checksum="457B150056E2BD5E" modified="2014-03-19" version="1">MLYALDNPLSSFWQRLSQQPYPAKPEGLPVADWAFELSLSPWVPLLTGVVYLFATHATNNRFGPGKPKPADLVKQSYGLSQTVLGHNILLAVYSGWTFFHAATRILSYLLGGALAGGFSGLTNAYCTVPIADSSFAGLGIYVWLFYISKYYEIIDSVILILKGKPVSNLQSYHHAGAILCMWAAYRYSAPAVFIFLLFNSLVHTLMYTYYSMTALKLPFTGGLKRSMTTIQITQLVVGCGLAASYTWLTYAPSAYPAGAVPTPGRHVLNPVSSAFSSFTSAANSTASDSKFLASTSTEALQLIKQAILASVGANQKTACVATTGQLFAVALNVAYLIPLIYLFVSFYIRSYQKKAAKGAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRM2</accession>
    <name>W3VRM2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_01515</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRM2"/>
    <dbReference type="HOGENOM" id="CLU_015631_0_3_1"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000008">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS64268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="505" mass="56319" checksum="206EBEE83E65201D" modified="2014-03-19" version="1">MVTTRSASRTPRKSRGRVSFPSDSVDNSPAPATPTPAPRSNSSRSSPTKKSSSSSSSTPASPAVRRRKSSVMSQKSLSKEQLGPKTTHYEFAGPLGAAFVSLTVPFFSYYLYFGCSEKLGCDLRLPIDNPDAIRSLLVQGVKDSLFDTTAWSIYAAWYAFTVIAWLVLPGKDFEGTELRTGQRLHYKLNAFATFVVAMAASAAWIFVKGADSFTIFYQHWPGLVSAALFNSFAQAVYCYLVSFADGKLLALGGNSGNVLYDWFIGRELNPRIGSFDIKSFNELRPGLILWAILDISCACHQYIQLRGRITDSMALVCAFHLWYVADALFMESAIFSTMDITTDGFGFMLSVGDLVWVPFVYSLQARYLAFHPVHLGIAGTAAIIAVNLAGYYIFREANSEKNQFRNGTNPKNLKYMTTASGRKLLTSGWWGRSRHPNYLGDWTMAWAWSLPCGFATPIPYFYVAYFAVLLVHRQLRDDEACQKKYGKDWDKYCKLVRSRIIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRY0</accession>
    <name>W3VRY0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRY0"/>
    <dbReference type="HOGENOM" id="CLU_1294902_0_0_1"/>
    <dbReference type="OrthoDB" id="10669211at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="213" mass="22972" checksum="2C522E2245825163" modified="2014-03-19" version="1">MTVTQSDRRQPPTVSQSMCLPSGAEDGTGVDLPFNGIAAGRDFRFCYLAKRAECPDSLLGRVHVQPSSGIMLSTPPSHDPHDPAECISGCSLLDPLARNTSGDFAECASQADRSLAWDARSEDGPDDRTGATLPFLGRLPHPIAKRPRRKGRPSFANSDARLPESWMHPENCCARRHCSGLRHAESTLGHGPSSWNHAAQHAIETIPTATARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS21</accession>
    <name>W3VS21_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS21"/>
    <dbReference type="HOGENOM" id="CLU_024220_3_1_1"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="571" mass="63219" checksum="DD2DE46982EAABEE" modified="2014-03-19" version="1">MRSSVWPGLYIAAGILLRVGLLLWGQHQDANHAVPYTDVDYYVFSDAAKMVVDGCPLSAIVEHLDYDSDIDLSGRKDVQCANGIVPESARFLLLNDPNSHAPTDGLRPDESDAMYYWAKRSYRFAKPTFDLFASLGDPYARPTYRYTPFLAVLLAPIHLFGWADFGKYVFAASDLLCAVFMWLILDGRRPQASSAGVFVHLPGLLWILNPMVAQISTRGSSESLVGLFVLSFLYFFLKANPEAPLGLSAKYLPEFGPASASTDVDNKAGEAKDVVAAATYEALPPESASSLLDWSLEAYIAPTLLGLATHLKLFPVIYAVPVLAHLYRSTVSAYAPERRASLSLWTRHAAGIQFGFVAFYAFMGANMAAWAVWGTPFIEHTFLYHLRRADHRHNFSPYFLGTYLSLFASSTHGGSVLERVLASPLLSFLPQLGVVVALGYHLGKRDVVAAMTAQTIAFVAFNKVCTSQYFLWFLWLLPLVWPSLKVGRIETGVAVATWVGGQALWLSQAYQLEFQAKQVFVRVWASGLVLLAIHAGLLVWFLSSWARFRAEIQKHGLKLRDGKLVKTLKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS38</accession>
    <name>W3VS38_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS38"/>
    <dbReference type="HOGENOM" id="CLU_1731220_0_0_1"/>
    <dbReference type="OrthoDB" id="2555959at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="148" mass="16181" checksum="27DDEAA965D75602" modified="2014-03-19" version="1">MMNPTLASRAFVPSRSLSTSSVRLLRPRTSTPTSASQPVLQKNAPPPPTRRSPVQSPPPQPRPGKRGGKEGSVYASYRALPYNTKLVFWTCGAMFAGLGLLAADKLEQLFPARNNRPTESKPDAQPKLIDHKPRLLAISVVDRDPNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSA0</accession>
    <name>W3VSA0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSA0"/>
    <dbReference type="HOGENOM" id="CLU_1332797_0_0_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="206" mass="23586" checksum="4344E4FF215A0283" modified="2014-03-19" version="1">MANDYSHIHTPIHPRAPTANLVSCKVLVSLIGQVAICGGFQLWAFCYTRRQDWYEPPEINPDELNTTNPENSAVFLISSFQYIVGSLVYSTGYPYRKPVYTNVWLMATVVLLLFFSIWALFTPSGFLFDLLGLVAFPRSFHVALFIAVVLNTLLCFLFETVFAKYVVRCVKAIQRVVRRSRRSKTRKHNSKMYKAVERSMQLDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSE2</accession>
    <name>W3VSE2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSE2"/>
    <dbReference type="HOGENOM" id="CLU_273124_0_0_1"/>
    <dbReference type="OrthoDB" id="2554418at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="884"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1213" mass="125102" checksum="D5D8855939F63E41" modified="2014-03-19" version="1">MDSQPSASSSAAAEAASRAHARASASTTAHAVPSSSSPSLAPPSTSRFGSQANPFRRSSSSSIGANVLARFTRSASQRTQPPADIPNDAHEPHSRPSIGRRISSRASRKSLSADPTSGANLAELSKPTGKFRSGVNWGPQQAPEPFMDSFDTTDADRKLAESLQAEAALASGSTAAAQSHAQARGLGQPIFVERPSISSAATTNTASTADSPSPPTSTSQLPTVSQTIAALTASGINPDVLATATPTKSSSPPSQPYPEQPAPAERTSMHISDDTIALAHPDGATVADGDTPCTTPPPKSRQPSHGENGSATTDNHMVARAAQLVLEAARQQARVETRKKGRSAPASPKRMSSSLSPIPTVSPDANASQEADVAPAQASLTEPSQPSSQRDRSKSDAAGQGAGVQRRKSFLRSMSARARREKKDTSEGSETPTPTSNSPIIASTTSSGTTTPATRRRRYADTRDLDLLARELAAEAIAEQLQQQQFQPPFARPSRSGSSSPLRSKAAAFNDPRRRSFPSILEDSPLQDDSIIPVSPASGALKPMTPLSPSSRSNPRNRASDAKSKAGIGSPSTASGLPADPTNGLVPQEMFLGLGGSPYPSLPPGATRAGVSSLDNLDPFGIPLTQESSPFDATTAYANKTSVYHTPNQVAVSRSLSGASTWSAAQTSPSAKRRPVLTMTMNDPQAELQGLTKPPKENGKRLTPFGSRAGSRAPSPSPSFTNLKKEAAAQDSSADAANDGSEVADAADASLLAGKPTSAVQSENNSVHVPSRRNSLAISDKGSRSSLAPAKQQKKAGRLSTMFRSGRSKEQSDAASSAKGSSAHAVATSASSAEASAYATPTGETSTLALSPVSAAVSADSDADISPVAFRAVELPATQDAARRSAPASASASRRSSMALEAADRPAPKKRPIRALLRRLSSFSKSDAKDTAKDNSAKANFPDASTMPIVDMDKLKQLSQNPDAKTTELAVQEPPSESSKEAAHSAPEVASANGSDPVTDKDAADVSGLAPRIQGLDLSNASPVPVNQEMAKSGFGTRSAYKFGHNTSTDSDVRKPGSVTLIASPGDENQDSTASLGDANRATDKATDKEDGWERPGAAPIQRADSQTPCSEDSFFLGSGQSTNSRPGSGALMKHGSESAMSEELYTPDPSTAYLPATKADGAADPVRHTGMLEESTLSTVSSATAAAAAKPTVAEPVVTAVPHDEATRLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT47</accession>
    <name>W3VT47_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT47"/>
    <dbReference type="HOGENOM" id="CLU_011072_5_0_1"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="168"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="657"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="690" mass="76009" checksum="A8167B1A47DB7DDD" modified="2014-03-19" version="1">MPLAQSKNTVGLGRAILNRRAKEAKQRNQTEFHTTDINNYGSVSNLRSVTHEGDLEEFLNTASLADADFTAERRNGGVTVITAPNRERTRHNPYLLTGQEEQEVLKKHVQNKERLRVPRRPEWTSATTRAQLERAEKDGFLEWRRGLAQLQEGVGLVLTPFERNLEVWRQLWRVIERSHLVVQIVDARNPLRFRCEDLEKYVSSLGIGSTNGIDYLEEDSPLKGPRSNLLLINKADLLDDQQRKYWADYFDAQGIQYAFFSAANAAAIQQARAEEEERLRLEQLKLERDDDEEDDEDESEGEDNDDQHPEEAASQPAAADQASHDSQADAHDQAQVVDAVTATATTTLSPDRDPTRVLNVLELEELFMACAPPLDTFAIDDQPAPSKLVVGLVGYPNVGKSSTINALLGEKKVSVSSTPGKTKHFQTIHLSPTTVLCDCPGLVFPQFATTSAELVCDGVLPIDQMREYTAPAELVAKRIPKDIVEATYGIRIDTLTEEEGGNGVPTGLEMLTAYAVARGYTRQGQGNPDESRAVRYVLKDYVNAKLLYSHPPPGVDSDVYNAAQRERARAALAGRKYDPSTAHLAEHADELDADLDGELAEMARSRAPAGPRQSAKSKALDSAFFDTMASARPTIVGRTGLPTAAIQGRIANDGSVIKQAPGANAQGQANSKKHNKANKRKKQRSGAGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTG0</accession>
    <name>W3VTG0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTG0"/>
    <dbReference type="HOGENOM" id="CLU_038289_0_0_1"/>
    <dbReference type="OrthoDB" id="2555863at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="401" mass="43016" checksum="32C2A67E5D07A1EC" modified="2014-03-19" version="1">MSRETPKESLGFFSVLLGRGTNNLKQGASQGVEGRTVQPSTSQGSTAAARASLSREANRRDTAANAPAPRMSGAAAFEAAVRSHARSSMDRSRSNIRDDARPQQLSSAMRSPQKDRFFDAHEAPEESKQSTSARSRHARHVSFQSPASSLRKGRSVERGSDAAAHSSRKSLATPAPARPEPRATKPKHSRSLSKAEQEARNWNSSTATLQNVEEPRAHSTRDRRPAKGAYPLATDARRDSFQAVRASGPDRVIIVTGAPGTLDHRAPLGSKPFASPQLAAPVPAARRPAPTPVVASKTRHAPRDGTKASTRDSAVETSKSNRQRPGLTRPSAADADADAARAARRSQRRIDTNAPRISTSSRPLPTAENGDSRRHPVSQTDGGILPPRDRHADSRSRGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTU4</accession>
    <name>W3VTU4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3'-5' RNA exonuclease USB1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTU4"/>
    <dbReference type="HOGENOM" id="CLU_906494_0_0_1"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="307" mass="34082" checksum="2404860C3D6E9D30" modified="2014-03-19" version="1">MSGRSERLVSYSDSDSDETAPPLDQGILPVAQPTASDNDDLAKVAPPRGAHTHRIKRKLQPLDDDSLQQASRPAARDRVQDEPKTAYARGEWLCYCFVEVPMTPSLRTLIQESHSHVEQGLLQAFPDKACLLKTADAEESSETLLSTTGKLHISLTRPFTVRAHERDEYVKTALAEIGRFSTGMTSFSFSFSRIACLANDDASKHFMVLEVGPGRENLRKLSTALGAELHRAFRAKSYYQEARFHASTTCLSAPPSNDTDADMLASRFRALIDSVESEWGSKLRKLPPFRISRIGIQVANRITYAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU69</accession>
    <name>W3VU69_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU69"/>
    <dbReference type="HOGENOM" id="CLU_400164_0_0_1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="334"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="604" mass="63412" checksum="D7CA34314FCDF809" modified="2014-03-19" version="1">MSLVQPLQPNHPAQPVQPVQAVQPVKSQPVNAAAKTTALLTCLGSGPVARADRTKITPLVQAAPHHSDGVWLTLTPATWGFKLDANVADSWNPTVASDAALDSIASDRVKLMHCVKQENLGAPATAPASAPAASPQRAGGSGSSLAGSIGTGARKPVSGTFDGTSIKAGGVGAAAAVAAPAADFGAASDFAFDAQMDTPPSGAPAAPADPANPVNPAAPATPDAPATDGSSVAAPAAANAAAAGSTGASPGSEMSAGEAAVAIALEQAKGSAGMPLLGQNASDTTTTSTCTKIWTRKEYSTMTVEEKTQFANAFKCVRSKPSRFKSDPGWNAADDWTLLHIRMVKYVHFSAMFLPFHRGFSAIVERDLQECGFQLGLPWVDWTLTAEDPSTNAIFDGNPAYGLGSNGQGNNTNCPWKTGREVTDGALADHWFNVPFKHKLCRQFNNMDVKLPNEHFGSNCTTFISESFLKGLALTHNDGSFFDFSSAVEISLHLAMHTSAGGNLAWLSTSVNDPVFHPHHGHIDNLFSSWQDMNPKNKRAFHGPKKQQKDGAHPPWNAKRTDMINFAPLADSVAVEDLLDHTSGKWGGRMCYRYDRPIDLGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUA5</accession>
    <name>W3VUA5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_00546</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUA5"/>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_1"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7 15" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="16">
        <location>
            <begin position="205"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="233"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS65090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="543" mass="60344" checksum="14DF332E4691455C" modified="2014-03-19" version="1">MSEAIHSQYDSILILDFGSQYSHLITRRCRELNVYCEMLPCTQKIKDLDWKPKGIILSGSPYSVYDEVAPRVDPDVFTAGVPVLGICYGLQEIAWNHGGKVDPHDKREYGHAEVEVVKTGVPHLDALFKNWEGSVQVWMSHGDQLSKAPEDFVVIGKTPTAPFAAMAHKSKPIYGVQFHPEVTHSVRGVELFDNFVDICHCRRDWTMETFIDKEIKRIREIVGPKGQVLGAISGGVDSSVAAKLMHEAIGDRFHAVMVDNGVLRTNEAAQVYEMLSKDLGVNLTVVDASEQFLTKLKDVEDPEQKRKIIGNTFIHVFEAEVAKLEKQAEDEEAAALAAGKPQEAKGKFEYLLQGTLYPDVIESISFKGPSATIKTHHNVGGLLEDMKLKLIEPLRELFKDEVRALGRLLGIPAHLVGRHPFPGPGLAIRILGVVTREQVKILQHADSIYIEEIRAAGLYDQISQAFAVLLPVRAVGVQGDKRTYDQVIALRAAATTDFMTATWFPFPPEFLSKVSNRITNEVQGVNRVVLDISSKPPATIEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUQ8</accession>
    <name>W3VUQ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUQ8"/>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF10">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE (NADP+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="492" mass="52720" checksum="F6251F7CD23F7F02" modified="2014-03-19" version="1">MNTRLKDMSLLDAADFLKGPESLEASDNESFDVMDPGSGMPICSMKASNLKDVDRAIQAASDAFASYSALPARERATLLLNFDRLVRDNLEDLAWILVYETGKPLEEARAEVQYALTFSWWFVGETERVQGQVVKSATNPSLRFLTVLQPVGPVAILTPWNFPVALFIRKAVSALAAGCTIVAKPSPETPLSTLAVANLLHRAGFPSGSVNIVLASYRNTPAIGQALCTDPRIKKLSFTGSSRVGRLLMQQCAPSLKKLTLELGGLGAYLVFEDADVDGAAAALVANKLRHAGQTCISAQRAFVHESVVDRVLKCIAAKLDQVQLGHGSQSTTTLGPLQTERSQQKAREHIQDARAKGATIYTSTAAVPSAGYFVAPTLIAGCTKDMLVFQEESFGPLINVATFRTEQEAIELANDTDMGLTSYVFTKDSARLWRMFEQLKAGNVGLNVGGSTTAAEIPFGGVDQSGFGKEAGIGAGLKEYMIEKSATMSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUS8</accession>
    <name>W3VUS8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01049</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241176_0_0_1"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1326"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1436"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1590"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="341"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="602"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="691"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="844"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="923"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1163"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1258"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="944"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1039"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1198"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1215"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1278"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1289"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1694" mass="178041" checksum="EDE90A8847D11494" modified="2014-03-19" version="1">MRSPDLEGSSTIAAAPSTSPTPTPSSPSLNRTPRWGSIRQRFSSIQSRDSISANADSVDDGMWDKNDTAFLEEVARASPLLLASPDRSDSLAPVLEHDQSRLPIHLSSRTFEDASHSSYSRRSMQPQPSSASSSTPSSAASATSATSTPVVSNEDVSGASPVHGYSKPWPRTMRRMASATVLPDLPEQKRADDLVSFRRPSTASSSPQLLPPIGPSTPLMSDNFATAHGFQSPNGRSTTHSSLRSSPSLSHSIYAGPDMTRSALAEQYPRSPSIHSASSYTAAGFSWKESAIHPEGRARASSSTSDFGDALAPPIVGIDRRTSRSVVGSPLAQASHFFATASRSPDASIRSRSSISTRPTTAPEGSVTRQSSGFSRATEPFPAGQDFGMGDSDDHGTASPRGKRMATASMRGVPGSPTKKSASIASPTAAHATFSSTPVAAESPTVTAPDVRKHTKNKSSLVSGLRRLMGKREREARGAAPPLEISSPQQFADAPSADKVVSRGPNLAPSRFSDASATLRSRALSMDGAPSPGGLNLLGLADDAFGPDNALPRLRTHVEDSPSRSNGQDDNMRASPNLARRSPSLDLLRGFGGLSKVASPVYSAAGQDRSAADPASPRSRTKSIDGLAKPLRDVLTHRPRRESTTRGASRTSVIEHISHEEARRLTGSAGPTILRTKEAVEEHRSTYASFPSEIGLPDRAHFDMHQSGSPAPRSQVLEDATSMADQSASQAATHAPSRPQRPHDRDALMAPPQDTPGQPSNGTGAGNSNRGGVSSSGSSFTSTSSAITDSAGAQRTPFSFQSQAYRPLSRDPRSDSKAMPGSPASGSSLGFHLSGDLAGLGPGAFDSGRGLHRPSSSTGSQYALASARGGLPAQTASSMMPPPSLSSSDTAKRGHASRRSLNSLVGSKPWSSLLGSPHMGGGLALGSSSSHRKRVSTMAISRPMSVSTSAFSTDATDLSPDRLADLTLRPSDFEGARSRLRVDSTLSNFSEPSQWEPPSGPLGVALTPHAATAESSASSHHSHHSHRSHRSFQSHRLAPTSSNSALRQPTLGQASRPTTGEGFSLDHRSSPSLAAISAHLDDPPSLNRSSSLKGLSNVRTTDSSVFVPTLAAAAPISTRPTPRPLSSGSVLAHRKRPSFGLAIEPAAHSAFDSIPSPLLRTRRGSLALPDGSNSGRPFSSSSASAGRTTSDSSSRTSLIQSARASAGTLSSHHTFASDDKLEVETVRDGSPTKLPSDQPSPLRDDSVAELEIAMSAVLLRPPSSSHRHSVSVPMDEGDSPRQHQEESWSRATGATQGPRQPTTSRVFMIHSPNEEASASPSSGRLSQATKDIAFGSIAGMVSKVFEHPFDLVKVRLQTQSADRPPRYAGAFDCFKQTYLQEGIRGLYRGLSMPVLGATLENACLFFTYNQIQSAIRWANGEASMASAAQADAEAPLSMAQLGIAAAGAGSVTSLVLTPIELIKCKMQVQMITREQQAPLASSSSHAAGAATTGAQLQQQRSLYTSAVRSSAGGSQASAQAFKTLDGPLTLLRRTVATDGIRGLWLGQTGTLLRETGGGVAWFLAFEGCSRSLIARKRAQQRRNDITKKDLSSLELVGAGALAGISYNVVLFPADCVKSTMQTEQEMRAASHGAVAGQKWKGTGFFDTFKKIYTTRGVRGLYAGCGVTCLRSAPSSAIIFLMYNKLEKLSDSYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVS0</accession>
    <name>W3VVS0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00831</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_3_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000078">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="634"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1100"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1184"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1284"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="374"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="726"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="1059"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1381"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1623" mass="179082" checksum="FA38AC7687F83FF3" modified="2014-03-19" version="1">MDGSAPVEELGSLSNFDASLQAHVVGADPVLSLPLRLFSSTLGQLRRHSTLSNLCDNVEGWGPVSQHRDLDFTPCFQEAAFWTAPVFLLAVFGGIHLAILSKRQDRTLTRTSRAVLRAKHVVVAALAIAAAFQASITYGLFAKPGESILFWSSIAGIGGYLVVLPLQHFNHLRSRRSSDVLLFFWLAHFFASIVKLRTSITPPSLPVKDQLVTLVPFLVRFVLGIFAFVLECLGVELGSFDDADQKRASSVAARTNGNGYHAAPAEANGSAFSVFTDDREANAHNNDPVDSGNECPVVTANIFSRITFHWMQPLMTLGAKKFVTEDDMWALPANEDAENLGRRFDQFWEQTKNKSTGKPAFWTTLAYSYGGPFLFAAILKMAQDTLAFVQPQILRKLLQFVQSYESEDPNQSAMQGYLLSAALFCVAVTQTSFLHQYFQLVFVTGMRVRAGLVSAIFKKSLRLSNEDRGGRATGDIVNLMSVDATRLQDLCTYGHIAWSALFQMTLAFVSLYNLLGWPSFVGVAIMVVSVPLNTALARYLRRLSEKQMKVKDKRTRLMNEILTNIKSIKLFAWEEAFTRKLFKVRNDEELKLLRTVGVVSAFFNFFWTAIPFFVSLGTFVTYAYTNPEPLTADVIFPALALYQLLSFPIAMFAGIISALLQAQVSAQRLSDFFDAGELDPLARKVILPGQREPVNPDAPSRPGDVLEALNDAEAREPQQGDEVVTIRDGEFKWSRSQPVPTLQDINLTVKKGELLAVLGKVGDGKSSLLSAILGEMVRTDGETVIKGRTAYFTQGGWCMGATVRDNILFGLKYEPEFYQRVVDACALTPDLNILPEGDRTEVGERGVSLSGGQRARIALARACYARADIYLLDDPLAAVDAHVGAHIFKHVIGPEGLLRSKARILTLNSVACLPDCDQIVSVRRGIILDERGTYDQVMAKKGDLYNLITGLGKQSAREQAAEDGEGDVSAKELEVIDMDKELDSHGQGGDEDLKGSKLHRRISSASMVRPKTLSKRQIKQDTIRQLKESSAPKEKSEQGSVKPEVYRQYIKSCSVLGVVLYILAQVLSQVMTVSRDVVLKQWGAANSENGGDPSTTRFYLILYGIVGILASICICIAPFILWTWLVISSARKFHDNMFDAVLRSPLQWFETTPTGRLLNLFSRDVNVIDEVLPRVIHGLIRTMVVVLGVLCVVAYSVPPFLIAIIPLAFAYRAVLRYYLATSRELKRLDSVSKTPIFTWFQESLGGLSSIRAFGQESRFIATSEARVDRNQQCYFPAVSCNRWLAVRIELMGSVIIFVASTLAVFIRTRNGKMDAGLLGLMMSQALSTTQTLNWVVRSASEVEQNIVSVERVMSYTDLVSEAPYEVPDQTPPEDWPSKGEVSMQSYSTRYRRELGLVLKKLNLDIQAGERIGVVGRTGAGKSSLTLALFRIIEAAEGKIVIDGIDVSKIGLKDLRSAIAIIPQDPQLWEGTLRENLDPTGRSDDAALWKALEQARMKEHVQSLEGGLDAQLTEGGTNFSAGQRQLICIARAFLRNAKILVLDEATSAIDLETDAQVQAIVRSEFTGTTITVAHRLNTVIDSTRVLVLKDGTIAEFDTPDNLLANKQSIFFSMALEAGLAKLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVS9</accession>
    <name>W3VVS9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVS9"/>
    <dbReference type="HOGENOM" id="CLU_039535_0_0_1"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF161">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="370" mass="40382" checksum="71365034D13F6AB0" modified="2014-03-19" version="1">MPTKGSDGAVDPNFPAGLRIQPSSSNRPRPPPPTTTPDASSHTVPSDGETPSWEVDTAQDIELYGIAGRIWEAAYLLARYLVPPSKAADSLEFDPPCSLFPVPGQAPLTIVELGSGAGYGSLHLARQLVRHADVMVEPPPRTRLVLTDLENVVPLMERNVERAGYKDATDILDARVRSLAWGNQAHASSLIAEMQGNDGSSGNPITHILCSDLVYFPELLPPLLRSIISLSNPSNSDTKIEPSTSPGPQLVISYKIRSLTKEQPFWSALGSWFEFEAVDCRTAKGEWHRFGSEGADYGASADADQELFVFVGHRRPDTFDRLAPERDTELMLGKRLRPGAEWDSYELETPASGQDYFEWLLLSNMGAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVW0</accession>
    <name>W3VVW0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVW0"/>
    <dbReference type="HOGENOM" id="CLU_033356_0_0_1"/>
    <dbReference type="OrthoDB" id="341353at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF72">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="97"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="584" mass="64244" checksum="81F3A6E8456047C8" modified="2014-03-19" version="1">MSQFVFADRFVLPEGSALASTRLHTIFYASLVVQHVVFHALSQSWLKGDSKDMLKKRCWILTTLASFVMCIASLPYLYDLIIGGFDLQSLRPRTKTVAEPLAAFFVAYLLSDLTLGSIYYRKLINLSSGWIHHIAYTFLFSLWVHKGWGHIAAAAAIFELPTLIMGIASIHPPLRSNTAFTVTFFATRVFYHFALLLCSVTPHGRSAPGINGSWGPAISLVATYPMHLWWGYKCICSIRRRMHKRKLEAAQVAKEKASLASAAGQLFNGLPAPDTSSAVNTPAVTPGAGATPATANFGATGPVHAAFARAAAVTRPPVNLFMPNRRKTQRKDIQLASVPPLLSKTINPNYINSNSVFTAPVAPEGAGPNDTEPFLAIRSPAESSDRARRLVADAVRKVWINAPTSWRRQFEEEAGVRPRGFASSRVPSYTTDESSEEYEEADSDSIASTTSTTLASESRARRYLQAQRSRIRSAVLRAVRTAINGRDADGFKAVSSHDGNVITTFADGAVVAAGDVRPTGLDRTLLSLDFSSLIKYLPPDFFGQEYEIREFPVEQVAQGGRRRRIVGQIRRRMEVARQDFVVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWI1</accession>
    <name>W3VWI1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWI1"/>
    <dbReference type="HOGENOM" id="CLU_068307_0_0_1"/>
    <dbReference type="OrthoDB" id="2550057at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21177">
        <property type="entry name" value="LPMO_AA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.50">
        <property type="entry name" value="chitin-binding protein cbp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051024">
        <property type="entry name" value="GlcNAc_Chitin_IntDeg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34823:SF1">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34823">
        <property type="entry name" value="GLCNAC-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833459" description="Chitin-binding type-4 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="4">
        <location>
            <begin position="29"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="312" mass="33386" checksum="22E84613B23FB583" modified="2014-03-19" version="1">MSLRNLSVVRLFALVAIVSHLLIAVVEAHGYVTAPASRAYFCKTGKAKDCGEIQYEPQSVEAPKGLPFARNADAKLCSAGLTQFAQLDRQGAKVWPTTKAADVHSFSWTFTAQHATTNFRYFITRPDWDASSTKGLTANDLESDPFLTVAMNGKAPPATMKHDLSKSMPTRTGHHIVYAVWTVDNTANAFYQCIDLDFGGSHSNSNFPDVGSTSPQSSSTPKPAAAAPSSSASSSSTSSASNSNSNSAASSSNSSASSASTPASTSNTDHRNHSVKSKSCRLKKRRQPNSSALAARADYRRQPMRMLKRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWS8</accession>
    <name>W3VWS8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00336</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWS8"/>
    <dbReference type="HOGENOM" id="CLU_1441605_0_0_1"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS65262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21175" checksum="87E5265FC2531303" modified="2014-03-19" version="1">MATHRDAKFPGKPYIDPAPMPASQPHIDELGVTSAPLKSASFFIGSHCKDVNEDFMLCKNENRDPAHCLKEGRRVTRCARDLIKKLSDSCGKEWEAHYQCLEQHNQEFYRCRKPEKSLNQCVFDKLVRSLIISASALDPGLTMYGDPLRSSSLLPEIGQEHPGIARRTGAGPREEEPRLWMSAFPPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDB6</accession>
    <name>W3VDB6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDB6"/>
    <dbReference type="HOGENOM" id="CLU_1038711_0_0_1"/>
    <dbReference type="OrthoDB" id="10502775at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="268" mass="28925" checksum="D4860D068E999022" modified="2014-03-19" version="1">MQAHGTARGSAGVDATKSRMPPVAASGRAPHYFSDAVQQAAVRRGGTAELCDEGHEQWQVTTLGLPDNARLAAWGRDAARQRRRRHHFEQLPLSSIPSGKSAVELRALFGVPVELEGSTAHTMPYRCLGVGPDREQQLRLGKSKEAAWLQNEVMLVRSRFLVVVPSPSSSNAAAAACRQPLSSSSPSLLSKPTAGASFRPSSLFARLLLPSLDQRHHTTPFATHQSDRPTLHTAANAPPSSRCIRSDPFCFSCILDALSYRSDPSSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDZ3</accession>
    <name>W3VDZ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDZ3"/>
    <dbReference type="HOGENOM" id="CLU_484075_0_0_1"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="533" mass="56835" checksum="E3196D2791FEB9B2" modified="2014-03-19" version="1">MSSADVIDALFVKTVDMVQSLPKSGPIQTSYEEKLALYSLYKQATEGDVSSKRPGMLDMLGRAKWDAWSKVSGLPPRDAKQMYVESMLRILRRFSDRPQAAALIQELENFSGQVAQRVMDGSLAQVDSDDESLTESDTDDQQRLDPTGLHQPPSGPSRQQPPPLQLPAHLAPHPPSVTGTSTAATRGGGAASAISTQRTPLASESEQDSSDDDHLGSQPGPFRSVARHPTPHAPPSIHSYRPQPRPGSVSATEGYARGPPSRSNVPTSSVHEASTTLRPRGPPSLQGGYTRHTYAPQSTAASVAGSNYPRQPEPGHYQRSTYAASSVGGRSVGTRTGPAPVYPPRPPSNAGSSHQPPRPEMELALQSIQASLAALHERLNRVEGRASSAAADDARHPSSSNQPATARLYHALMNIVDDVRQLIGLNAVARGPRSEALAPSFLAEGGGATNRSGAAFHLLTSPVRILVALVNLGARLALDIISLALVSSFFLYAFKRVTGRGDPLLMLRLLKRLQQALLRRAPASAKQLVAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE03</accession>
    <name>W3VE03_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE03"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="165"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35247" checksum="F025765C9D7F592C" modified="2014-03-19" version="1">MTPMPKMTPLSGALRAAPKLVCMPIVMSVLMSFRIAPITRTLPQNLTALRQFSTSLKSNMKPVQLYTAGTPNGQKVSIMLEEIKALNPSFTYETHAIDMSKNEQKEEWFLKMNPNGRIPTLLDPNNTATESEGFPVMESLAIMLYLEKLYDDQHAFSWPDSDPKAQNYRSQVLQWSIWLQSGLGPMQGQANHFRMQATGDSKNVVPYGLKRYHDETVRLYEVLERGLEGRDYLVGDGKGKYSLADMITFPWALWYRFAGIRNDEVGPNVKAWIERIKQRPAVQKGLAVPKPSELLKNLEDPNWMPPMPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE20</accession>
    <name>W3VE20_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE20"/>
    <dbReference type="HOGENOM" id="CLU_029953_0_0_1"/>
    <dbReference type="OrthoDB" id="2554732at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="625" mass="67474" checksum="7565938737F14BDF" modified="2014-03-19" version="1">MPSHSSSHPNARHASPSTSSSVKPTGWIRSSSATAGSATKPRVRVLSDRTNLPSSSHTPLKSLQKPPTKTLVASRLAGQTRTPAPSNSTKQQTLSRFFAPNTAPAGPSKSTTHAQTSSPSLDRPRLSSSDTRGAASRLRIPPPEPRSANNDTFNDAFNDDDLEARAACLLRGRFGSVSRSLSTSTSSTPPATVSPPTPPSDEPPRSPRVQTRSRVEHVRPPRSMLPPAEPRTPPRKRPQPNPPSSPFQPTLMAESLSNFTPPAWAKSIDRKLALFQRMAGIQDDVVREQERRQMENELDRAHQRMQGSSPAAAKSKRPPTSRQRTSLAKQSEAAPTGRVSTRSEQMPETLLRSPVTNRRIYALETQLMPVKRAALQPASRADKNASEVVQNQPLCARTDPFVAESADATQDESETLPLAWPAEGDDETQPLAWDDADEEAAQIPTEAVQLSNPIGSAGEVPTSDDDDFLTEPGVALDAAHDSTSVSKRRRVDTQRMAKPSPVSLTSASGAGRFDSVVAALRRQERRQNSGMQLSLDRYVTKPTCKLDSDDDLDVLSDDEAGDETQPLEWATPVKRPTLQLASSPAAATQLSTSSGASTSASEISLPSQTALNDADTQTRTFFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF85</accession>
    <name>W3VF85_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_06395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF85"/>
    <dbReference type="HOGENOM" id="CLU_276113_0_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF32">
        <property type="entry name" value="ZINC FINGER PROTEIN RST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="909"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="356"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1186" mass="129330" checksum="542750B80DABA2EE" modified="2014-03-19" version="1">MPKTISCPHAGCDYLFSKPVHLRRHLLSHSDEAVWKCPDCDQEFKRIDSFQRHKKRIHPDQPNLAAVRIGGDADADSSAKSDDEADDQIDDLDISMRDDDAKPFISVKRGATSPLSRGATASASATSHQMSSYNTPSALSNQRSSGSNYSSPSSSRHHGLAAATEPTTSMYTRAHHYHPYQRSDSAPQAAQSNNGDSSAVSHSQWPSQPAQSSMYDSNNAAASSSFSFYPNLYGAPISYNGYAAASSSSAGADALAVANTYGSAASGDASQTAAPLSIASLTAPSPSWGSSNSDTEAQTFFDDILQSILMDSISTFVPHETVGAPDLHNLTGAAITQDAFGFGDAGSAGQVMPSAQNSLQVQQPSQQTQHQTQPPSAVAQQEQHQQQPAPLQQDQNQGQSAQSAEVQSATTTSGSQQQQQQQPPQPLVNLVPFATFTDSAHNSGRSTPATPRHAHAGMDDADEMTRSVEKVGDQAATNIGARTRDLVLHGVNIPKKPPRLTAASLFSAATRHTRSMLPLLPSYWLLDHRRLAAERPYVFISLLALGTLWQPRADVKAYGAELWQLIFRSIWAGAVFYLDQPQLMREATAVMAYTHLYAFMCRDENIRRKSIHSTYTGSSLIREYGWRQGVWFLVGPWEESLQRVLGANIQMALVELEVLARDQSTNRLSAEQKRLLDRLHGVWKQWSDAEEVNRNMICHGITESHHSEFLTSHGQMRSMGRITCQALVPSADDVWDAKTAIEWARLVLEHKSRRENHQRPLLAGKRQLGPILDALWGVDAPSPATAGRRDSGESGELDSLEAKRELQRMLCFTIKEHFALLTLLEGLHLLWIARYMPPFRTGTSYAADFSPSQPTFAPGIESAFCIKGGTAYHHLNVLDNEMMLAALSRWMRLCHQSYLPNPVANGTGFSQPISSDGPSAAADKSGSSTDAGVAAKPGVQSIGPINDRFQLHFRFHVIQLSVLFNAHHVVHALVSSCGNEEANGVGQGGKAAAVRAGMQTAVPLRCESCTDADMCPYRNARLQRWAALHAGAVIGNFMSMPRLSNVTPTILEGLGQAFGILVILCRLQRPLAQRRRTVCRCDAEVREGSVELISDQCLHLDAERPSPGEGVKEKASAKFESSSDCWLQHGTLDEGAMLLGQPIQEWAFVLQDMGNELKSVAGTWQTAEEFLAVSQKMLNSFTFYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFN5</accession>
    <name>W3VFN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_05566</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFN5"/>
    <dbReference type="HOGENOM" id="CLU_011476_2_1_1"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS60364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="481" mass="52859" checksum="3D34E53D1514058B" modified="2014-03-19" version="1">MPSPYEPRSPRTGAAYERVASNTYDNSMSQQYPQHQYPQQYPQYYQRQQYPEEPYDAPTPALAADSYSPEYSMEDMRKPQSNRYSISSQPRDYADPDAGWVEKRSSGVPITTYATTSDPVGHRRKKIWTITGAVIAVILIIGVVVGIVVAKHKNSNASASSSSSKTNSNISSDPSKFKKDTALHNSFWGMCYTPFNSQYQYGCGVDLASVIEDVQTLSQLTSRVRLYGADCNVTALMLDAIQRTKTNLTIYPAIYLDQSDPNDAAWTRQVDNITFALDSFGTDHIGGISVGNEYLLNGGSAANLVAYVQRFRTLAASKSWSFPVGTGDAGSMFTATVAAGVDYFMANVHAWFAGTLVQDGPGWTYEYFETNDAAVAEAAPNKPAAYIAETGWPSGANTTQAETYVNENGQVTGAKAGVAELQTFLDGYVCDANKNGTGYFWFELYDEVWKDALYGGVEAHWGLFDKDKKLKQITIPNCSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFR6</accession>
    <name>W3VFR6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFR6"/>
    <dbReference type="HOGENOM" id="CLU_2062483_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="119" mass="12410" checksum="03087BB0639727D2" modified="2014-03-19" version="1">MSTARLSANASTRVFSYSSRSYSSLSARVARTPAASRSSIQSSSSLLATAARSNALASHSASLSFGVQSRLFSSTMTAAEKQLRPLGPGLCVWSLAVSAPRGSPFFSAPRQLGRTRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG75</accession>
    <name>W3VG75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG75"/>
    <dbReference type="HOGENOM" id="CLU_010811_3_0_1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="139"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="577" mass="63772" checksum="E9B8A23E5D038315" modified="2014-03-19" version="1">MADRSRGGYHRADNPPSMASSRPSVLTDSSSGSSSQKYYTMPVQQGGYAKGAYGPRSAPAAPLLTDDDDEDDYLYNDKALDKRSGTCISTRGMLNVLTLILLALGLLALFLGYPLVVVLSKVFDSIDINPKSPERLTAITQRGLLDPDTPQSAMRRTSPVDGSAWHLVFSDEFEQEGRSFWPGDDPYWEAVDLWYWGTGDLEWYSPEAVNTTGGALVISVEERETNNKNFRSGMVQSWNKVCFQGAYYEISARLPGSHTVPGFWPGLWTQGNLGRPGYGATNEGMWPYSYQGCDTGALPNQTYINGTGPPKALDARGLFSASYNNELSWLPGMRYTSCNCPGTEHPGPNHGVARSAPELDILEAKINVAGGHGETSQSLQMAPFDVDYYYGNSTAAGDIRIWDANTELNSYKGGAIQEAVSALSQVPDVAYENTVGGRYVTFGVEYSPDWNENGDASVTWYMDGRPMWTLNGQAIGPVPELDVSQRLVPTEPMFMILNVAISESFQVPDFTQLEFPAHMYVDYVRVYQRDGQPDRVGCDPANRPTYDYIENNKEIYYNRNITEYPKSKIPKNRLTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGA7</accession>
    <name>W3VGA7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGA7"/>
    <dbReference type="HOGENOM" id="CLU_033355_1_1_1"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834134" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="179"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="386" mass="38354" checksum="2476C50475281EC6" modified="2014-03-19" version="1">MKFLAALTVALSATAGVLAQNNGGENATAFAEGLLNALRANNLSALADAVGNNSQQLLGALQGGNKTVLAPSNQAFASLGNDVSTEALVATIAYHVLNGSITDSQISAGNKTIAASALNMAPYVNLPRNRSQVVVLSKQQGNNTNYVQLASGNVSFALTMDGPQYQNIRVQPIEQVLTIPSNTSGVAGQLGASSLAEALQSANLVEALDQSIVTVFAPTNAAFQEAQSALQGATMEQTAAVLLNHVVNGTVVYSTALGNTPSAISGSGNELKFMSNSSGAYVSSGNITAKIVMTDYVAANGVVHVIDRVLANTTQNTQAAASAFSSATAAAATQTAAPGVGSNGSGSGSGSGSGSGGSGNGANTLKMSTGAAAVAALLGSGFWLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGB8</accession>
    <name>W3VGB8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGB8"/>
    <dbReference type="HOGENOM" id="CLU_148322_6_0_1"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000202">
        <property type="entry name" value="Small ubiquitin-related modifier I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="93" mass="10393" checksum="F98B0D6A35DCCACD" modified="2014-03-19" version="1">MSDADVPQPKPEGGEQLNIKVKDADGNEVFFKVKRTTKLSKLKKAYAERMGKPENSVRFIFDGQRIGDNDTAETLNMEDQDEIDAMIEQLGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGG4</accession>
    <name>W3VGG4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclohexanone monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGG4"/>
    <dbReference type="HOGENOM" id="CLU_006937_8_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59256" checksum="3EA24A5B0BAB1D73" modified="2014-03-19" version="1">MLRKLGFNVHLFDAAPDFGGIWRLNCYPGARVDSEVPLYGLSFPEVWRSWNFSCKYPDFKELRQYFNHLDEKLELRKDCSFNHRVRSAHWDDAAQKWTLTAGPSEDKTVTVTAQHVIFCLGFASKVNIPKIPGMEKFKGKIIHTGEWDESIDCTGKKAAVIGTGASGIQVSQEIGPLVDRLTVFVRTPNLALPMRQQKLEASAQEAFKDIYPEIFEKRKKTFGGFHYDFDPRDTLSVSAEERERLYEELWARGGFHFWLETFHDLYANKEANKTAYDFWQKKVAARIKDPKKREILCPEEWPHTFGTVRPSLEQNYYEVMNQDNVEIISIKRGGDEGIKEITETGVRLNSGREIELDQIILATGFDTHTGGFKQIDIRGKQGLPLTDKWSQGCNSLNGLNTAKFPNLFFLYGPHGPTAYSNGPSTVEVQAEWVCEFIKYMRDNKIASFDVDGEAEAKFGEHINELSAKTLFHESHGWYMGRNIPGKPVQALNFTGGIPLYVTELDECKKAGYQGYNLVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGR2</accession>
    <name>W3VGR2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGR2"/>
    <dbReference type="HOGENOM" id="CLU_412844_0_0_1"/>
    <dbReference type="OrthoDB" id="2556808at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="665" mass="70783" checksum="6A7FD0572EEA005D" modified="2014-03-19" version="1">MASADDRMMFLQQFLTALFQPPASQMPQANDPASYERSRRSQAEAIANHYLDAVHLEATVEEALAPVPTHLPLLRLHALTPRQATDHNVRKGLYIAHKTRQFRIELPKYDDDIVGRKEALIKFGDDCLTSFFGPDWANPSEDSAAKATPSRIYSNAPAYPPVSSSFGPPHTCPHGVPIAPSGPAPAMPPASKNPSAPTHAAKAEVTPVKEAAEASQHLAHDLTDFDTDDESDYDSELEEELMHEFMQDRGYWDYDDLGYGSDDPYGLDYYDDPYGLEDDLYGDDLDYDPTSDPNFLEYYSMGYNFDEALDATINARAERLLGPHLRREMMMNAALKKGGKASKTKTRGGASTKASTSKMGTTKGQGKGSAGTSQQRTPGAVDSGVGSSKASSAKDGSATAKKKGKRKRKGKGKAKAQGQESGVKVEESRVASKIEGVKANHTAVPASVVKASGGSGPATVVSQAPASSSDKDPAGLQVQPARPQTISLAHKLSSETVQGSPRASVASVGLGLAGSPASVKQPVWHPVPHIKVSLPAATSGNTTTSPAPEASTSTSSAPNGAPTAPKGPRASTLIPTAREGEASLTSSATAPKAAGQTKRKRTDTSNNSVSSADKAKASAKVAKSTSAQNTDKPKKQPKFEVFVWKKRYRPSKRPYRDCWHAPFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH89</accession>
    <name>W3VH89_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH89"/>
    <dbReference type="HOGENOM" id="CLU_328758_0_0_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000310">
        <property type="entry name" value="Solute carrier family 25 (Mitochondrial phosphate transporter), member 23/24/25/41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="407"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="631"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="758"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="858"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="171"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="568"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="951" mass="100735" checksum="97CF58D6C81343EB" modified="2014-03-19" version="1">MTPAGVNSSQAANTAAPSSSRPAATDAEPPETRGPSASSSAASGSSKPVAASAAAKASSDAPSRLGSNFWSSWISPSSSSAVAASSAMEKRSKPRRPSFEEFRAEEPPQARLIRLRGLFDTLLDEDDEQALAGGRAREEWMKSARRARYGAGGSLARGSLAPSDIRNSTVGFEACTMSEHAEASSSSSSPSASTSSTSTPSASAKSPTADSKLPSPPPPPRQSYAKELLNQCRQCREDLEAQRARLAEEQAKRASDPGWTSSWGLPTWLGGTDPANQDADASPKGTLANVKDKILSTSVTSTTQQDSSQRPSSTSIATSLGSYLGYGGDSCSKDAKSAEFGHNPPDMEHEAGWTGSGVWGLSAVGHKKRAADRDRDEKVRRGQKVDDDGGARQRQIEWEGFLAYAENKERELYKLFVEMDKNCDMKLDVQEIRGALDRAGIDVPQISLDDFIASLTSTRPSAHASGEKTYVSFPEFRDYLLLLPRKPSVSEIFRFYQVRKAFGLFGMGGIFAELAVGWGKTERGAAVVNFDGDVSLAGEEKKRESPAVKEAKRAEKIGKRQEAAAAAASKAVEASAEDGTTASPATSSSTADVEGTKEKAAQEAAAAAKAASEEELTEEEEEDDNDMIQGAVALKFLVAGGIAGAVSRTATAPFDRLKIYLITTARAPDVAEAAKAAASGQAGANGAAAKAAGQGLGILREALGNLYRDGGGLRAFWVGNGLNCLKIFPESAIKFLSYETAKRAFAKYVDHVSDSRDISGTSRFLSGGIGGITSQLAIYPVETLKTRLMSSQNAKTSLQGNALLVKTARDMWQAGGMRTYYRGLTAGLIGVFPYSAIDMSTFEGIKLFYIKYTGKEEPGVLALLSFGSVSGSVGATTVYPLNLIRTRLQAAGTPAHPATYDGFWDAAKKTYVREGFVGFYRGLVPTLAKVVPAVSISYVVYEQSKKRLGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH93</accession>
    <name>W3VH93_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04965</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH93"/>
    <dbReference type="HOGENOM" id="CLU_001666_8_2_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase SMUBP-2/HCS1 1B" evidence="14">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="12">
        <location>
            <begin position="260"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="13">
        <location>
            <begin position="591"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="505"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS61028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="838" mass="90741" checksum="1CF7CBB7F8367FB8" modified="2014-03-19" version="1">MSSMLRKPEPPSQELLLRWFQTQARLLADERREEQAQSKLLLSKTAPKILEKHGLALLSLGVASIRIGVGAKLLVELERPSAYHSSPNFPPHSFRSGDLAAVLENSAEPQATTDSGVVEGVVYRVTETRITLAVSERQRTPKPKPEPEGGQNKRDARTGDKNKVSGSELDLPERIRLVKVANETTFDRMEVTLDKLARALGVSLGPASSGADGDSSTDEADTVEAGPSSNATTLQRALFGLSPPTWHQQDVPLPPFNASLNETQLAAIRHALSSDHVSLIHGPPGTGKTTAIVELIMQIVASNLGASEDAGRVRVLVCGASNLAVDNILERLVASAAHREVFKKKGVGVTRLGHPARVVASLQGATLDAQCTQSAEAQLVKDISKEIETIMAELKPTAAAAGNKSAKAKPKLRGSDRRKRWEEVRELRKEYRRRDRQVTSSVLDRAQIVLATCHGAGGRQLANRQFDWVIIDEACQALEMACWIPILKAREGARLVLAGDHLQLPPTVKSSVKPHRPKGKPARKKNAGGSASNTSEKEDRSKEDATTNPAVEEAKQDGDDDGDDDVELAQKLAAASMDDVRPTRLRPARSLETTLFSRLLGLYGSGLKSLLSIQYRMNTAIMSFPNAELYEGKLSAHDSCASITLSDLSNVQTDTGPDDDDLLAPVVLYDTSGCELYESSPTADEGVLLADSKSNVHEAELVVRHLEELFARGVGAGQVTVLTPYAAQVALLHARIRSHSFIGINADEIELGTIDSMQGREKDVVVVSLVRSNTDRQVGFLAQKKRLNVAITRAKRQLVLIADAECIAEATDLPDEFLPHYMAWLDEHAVVHPVAATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHA5</accession>
    <name>W3VHA5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_05712</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHA5"/>
    <dbReference type="HOGENOM" id="CLU_1103177_0_0_1"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="97"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="252" mass="27843" checksum="10BD03BF07B4D704" modified="2014-03-19" version="1">MGGGELPGAQGKQSGAKGLHRSKSERSPVAALALLPLDKGNNSVTPRPSIRVSRLTKTIIAATVSVVLLNTPPFGDTAAPHRIFVWLQHVLITMAGICRNRLAEERKQWRKDHPFGFYARPAKAADGSLDLMNWEVGIPGKANTPWEGGLYKLRMMFPEEYPSKPPKCKFTPPLFHPNVFPSGTVCLSILDEDKGWKPAITIKQILLGIQDLLNDPNPHDPAQSEAFTMFQKDATAYERRVRQQAREMATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHA7</accession>
    <name>W3VHA7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHA7"/>
    <dbReference type="HOGENOM" id="CLU_017098_0_0_1"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="89"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="625" mass="67566" checksum="31080BBF09D186F8" modified="2014-03-19" version="1">MDVGKLFKLPDLPSAAVNKRKWSAPQPADSASAGPSSSTPAQPDAPTPRPRKAARVDDEDDDELAPAEEETYFFSDDDEDGGRFFGGGLTAEQTQILDIMDGGDASSGAPPADVPALRKQLLRFERAITKNAEMRTKYAADPARFIESEADVDAEIKSLLVLTTQPERFYAEFVQLGGAASLVGLLSHDNADIAAAAIEVIEELTDDDVLDQVEARYEGDDDEQDAEEGRASAVAAMDTLVDALLKQSVLELVVSNLSRFNDQLDPALGPEEAAAKAVEVEGDAQAIYHALGALENLVTSRPALAEQLAASAFLPWALSRLASRREVDQNTSYTAELLAILLQTSESSRAHIGSTRAGDAGENAGENGIDVLLGVLARYRRQSPAGAEEEEFAENVVDVLCLSMSEAANRTLLLEGEGVELMVLLMKEKKFARMRALKILDYATSGPTGHAVCHRLVEASGLAPLVSTFLQCSASSRSGSESVQHALAVISSMLTHLDSDSPPRIRLLARFVAHDYQALDHLLDLRSALVSRLQRSDDEYLERLDQGLFSLQLLDTILAWLVMEDDAVRDHVAMLLRRNAASWQDVAATLQEYSDNIGDQLAISHPTEVKTKDILAALIEYLCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI04</accession>
    <name>W3VI04_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI04"/>
    <dbReference type="HOGENOM" id="CLU_061288_13_1_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="140" mass="15427" checksum="758C345CF48081A2" modified="2014-03-19" version="1">MSDAEYKEAFALFDKKGTGTIARESLGDLLRALGQNPTQAEVADLANTAPKDIDYNSFLNILNRPNGFKPAGTPDEFIRGFQVFDKDGNGFIGAGELRYVLTSLGEKLSDDEMDELLKGVQVHPDGNIHYESFVRQILSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI66</accession>
    <name>W3VI66_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_05643</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI66"/>
    <dbReference type="HOGENOM" id="CLU_006714_1_2_1"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="8"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="536"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS60431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="758" mass="81388" checksum="6847B9F9A0C13124" modified="2014-03-19" version="1">MAPKTLYEKIFDSHLVHEEADGTCLLYIDRHLVHEVTSPQAFEGLRNAGRKVRRTDCTLATVDHNIPTASRKAYKDTKSFVEQADSRTQCLTLEDNVKAFGLTFFGLSDNRQGIVHIIGPEQGFTLPGATIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTILQKRAKNMLIQVDGELSEGVTSKDIILHIIGIIGTAGGTGHVIEYAGSTIRALSMEARMSICNMSIEAGARAGLIAPDEITYEYINGRPLAPKQGAAWDQALAYWKSLPSDEGAKYDTVIKIDAKDIPPTVTWGTSPQDVVAITGTVPDPKDAKSDGEAKAMERALEYMGLQAGTPMEKIRIDKVFIGSCTNARIEDLRAAARVLHGRKVAEGLYCMLVPGSGLVKKQAEAEGLDKIFQAAGFDWREAGCSMCLGMNPDQLAPGERCASTSNRNFEGRQGAGGRTHLMSPAMAAACAVTGYLTDVRKVVGDSTAKVGSDAAKPAFEIQVSDAKSYLVDATPAPAPTGAAETDEDAIRDVPASKISTAGAGMDKFTVLTGIAAPLERANVDTDLIIPKQFLKTIKRTGLGSALFWPIRYDAKTGEPDASFVLNQAPYDAAKILVVTGPNFGCGSSREHAAWSLLDFGIRAVIAESFGDIFRNNLTKNGQLPVVLPKEQIVRLTQDAKAGKPITVDLEKQVVVTADGSEQFAFETPEFTRHCLLNGLDDIALTLQKDAKIAEFEHKRSVSTPWLDGFGYSAKIQTSPAKQARTDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI75</accession>
    <name>W3VI75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI75"/>
    <dbReference type="HOGENOM" id="CLU_1441923_0_0_1"/>
    <dbReference type="OrthoDB" id="5373615at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="103"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="193" mass="20590" checksum="52351C222ECCFDF6" modified="2014-03-19" version="1">MEGSIGKDEIVATTKFKPSSSSIAARQKKQQDDVVDDWDAESSDEDTASVQQNDAAETSPAQADVFRASKDEWTEANSQAPTAVPLVVSGPGRTLPGSAYGQRLNSRENGPVPSSPYAGSSATAEPPRILQRPKNVAPGVRSDGTPATMSDSSSQERKTVEQRQEEYRLARERIFGTPTNASGAPSRGRPSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIB1</accession>
    <name>W3VIB1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIB1"/>
    <dbReference type="HOGENOM" id="CLU_281883_0_0_1"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="219"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="898"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="944"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="815"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1091" mass="115361" checksum="8CEC941F1157CEC8" modified="2014-03-19" version="1">MQGLEALNPSPLASPSITHLTHPTRASPELSSSRAPRPMSQPKLTLRPPPHRDFIQGFPGIVGSGNRPPAHVAGTVEVRLGTKGLKAAWLRIELRKLETLPGGESWGELIGRGPIDVWSARKDEAHKSEAEKGWELLQTADFPFQVTIPEGLPPSAKLEKNAGIGYELVTSLCVRSKKGLLKKETTSSIIQNTHPLWLDKHELHSTWPVYSLPEDHETIQDDIRAKVMRNRTCYGPGDSVDVRVILISERVSPIKVKSVSFAIRETITFKGSAKKTFGSNKAASQKTESLSSKSKSFGKKVYKGDTHTFDLSCQIPRTHTLMTIQTAKHIEVSYTLRVQIETAKKPIIIDHLPITVSNFPKTASDALMDRIGWVPGLSTPADGTLPDPYLNEAAPHMPPGPMGRQQTIARSVSFSAGSTYSGSRSSYPGYPGGDLRRRDTVMTQGTAISGPGMAGRGVPGQVFSWGQYGSAQPFGAGDAPRPAFAGPPSIYEGRELAPEETRALFHSTNRPQSAMVLGTAVDPVLMPPSSYHGHSGAATPIREQSEDDHGQSQYRHSQYGANGYASNAAHYTSVPGSPALHRDSASASPADGRNPYAEVPHRMSATPEISATRYVRPEPVHQPIHPERQASPAPRQSTFDASAPMSSAEAEKQRLYERARQQAERNQRRADERRAQHQLAAMSISNPASPVANGGRPYSMMNLGSTSASAAPGPSAGAGNSLGMQGGPNSANSNPSMQAGASASIVSGRPAPYPSYMTAEEEKRQLYERARAETEAFQRGEASSSAPAAEADGSSRPAVAHGQASSISDNVGQLPGAWPQAAPAHASSSTPAPVAGPSAPAGSSSAIGAGATSSAGNEKEQLRRYYEARDAVNQHLQTGGSRQVSGSAGMYAPEVASAVHHATPHQPADTLGSPVRATTTDGVVPVQPTPMRAGVATTGVQSYLTEAEQQSAEEKERLASHYARKAAKAEAKAAAAANGQPRPSAGQVRSAADAYAGASPAGGAALPAGASEKAQLAAYYAARDAMQHNLQQESSSSAQPKGQNMHQWQPRYSSLDDDEPAPALAAAPPPLPPKIPLGTSAFAPSAHRAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIF2</accession>
    <name>W3VIF2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIF2"/>
    <dbReference type="HOGENOM" id="CLU_012946_1_0_1"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="80409" checksum="D44B982F43C4D366" modified="2014-03-19" version="1">MTVAKRAARAAPPASQARNATIARQQLESLLMPAGKAYLLGYVMDILPAILKALIKFVTTELKRIRADEKRLLEERRYAKESGQPHAKPRVLDGLKSVLPSFYRLPTLLHAIANALVVALGTNGMAISCFLAMAGWRISESLVWWPIAKYYALKLANPATSSEAQTVNALRQARIAATFVASSLSSALAMMMLQHQSDAALQAKKAPAQGGAGAPLLTIDTTPGWIPKSIRPSNLGFLGRRLNANNVPRIASLAPAGHFLSRLTSLTVPATPGLTPGSQGVSPSVPVSPDPRAPPSPSATLTPLPRASQDPVPTAEDAAAVQPGAKPPLGRPSPTIDLTLFALVRGMDTLVRALAAPAAASKNRLRASASATAATTAARRSRARALLRSVALGLADQTEGLVFVVCCAQIMWSWFYHPERLPPTYVKWITNLATMDERLLLALRCIRSGKPLHWAYQSKEMTPEGVHLLGSLAEELGHPYQWGDPTRLPNTAVEAREMAEQARAEAAAKRVAGQEVAELDGFVLNGAAGPRGRGEMGGMPCELVHCGTGGANCYKNALYRWLRGWRMSMAIYVPVHLLPRLLFNPRGFASAPLANMLKTLMGAARSAAFLATFIVGNWFPICLARSVVPRWLPGVPFTFWDAGIGQALGSIACGFSIFIEEKRKRAEMALYVAPRALFATAESAKPGWLSQGHRSALWAERMTFGTAVGVVVAAARYRPELLRGITAAMGWVARPPGRPSSGRNYARSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIL0</accession>
    <name>W3VIL0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIL0"/>
    <dbReference type="HOGENOM" id="CLU_1865983_0_0_1"/>
    <dbReference type="OrthoDB" id="10273106at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15099" checksum="0E9BD3F35B3B0DC4" modified="2014-03-19" version="1">MNDLSRVFVFKILATVVFWCFPLILLPPVALETLGFPKQESYIFVRLLGWAYLSLCVGYYHGLPASLDNRRSIGPIHVGIVSNGGASALLLWYGFHDAWSSWGAFARLVMWSSAAVTALITVGLYIHGVQGKLPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIL3</accession>
    <name>W3VIL3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 4E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF-4F 25 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">mRNA cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIL3"/>
    <dbReference type="HOGENOM" id="CLU_043552_2_0_1"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="275" mass="30156" checksum="4FFB2180D898FDB2" modified="2014-03-19" version="1">MSATTDLPKAPAEASKVALDSAVAQTLNGDAPATSEGEAASSSDANAAEYRTVFQDATNFNVKHPLYNSWTLWFDNPSQKGMASARGTKESWGDDMNKVVDFDSVEEFWGLYQNIVPPSELPQKANYYLFKQGVKPAWEDPANTNGGKWSIQLPRDKTRAAIDRLWLFTMLAAIGETLEAPFPDGVPPPSSSPQDELVTGVIMSARANFYRIAIWTRKAEDTEELAAKLLDIGKQFKVNVLGYDIDAKIGSGLTSDVEFQSHKESEKKKGKKTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIP9</accession>
    <name>W3VIP9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIP9"/>
    <dbReference type="HOGENOM" id="CLU_897488_0_0_1"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="310" mass="33243" checksum="2303D39A15CE1D35" modified="2014-03-19" version="1">MLPAQRNKVDISSLNEEEQKLFRLYGKLPKKDLLQNRLKERKYFDSGDYALSKAGKAPQQSVGTAIPNPEMIPHASTVTSPGANAVSPPGSLPGQQAGGLAGPVNVPGAERLASRPQVSAFPISGAGSSPAPMPFIILPPASTAASYSVHIIHLHSVSTLSSSPAVCLGPRPHSQDFWNNSASPFSVALHVRAGPRQQTPGSLVAHIGQHRCHVQQGQSMAGTRAFAFQTSLVSVLSPWSCRKWTTPCPSHLHLGSERGSGKALHRLGGRRSNMLSASRFPFAFEDPEVARHDASRRPRVLVSFDATEHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIR0</accession>
    <name>W3VIR0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIR0"/>
    <dbReference type="HOGENOM" id="CLU_556911_0_0_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF799">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="4"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="477" mass="51727" checksum="8DAEED4AB5927000" modified="2014-03-19" version="1">MERDFTVVFRVRPSLLDNPSPTGLVESASTGELKINEPRTKLHTCADEYTPHTFLADASYLAASTSDDIFRAHIAPLIPFVLTGGFATVLAYGQTGSGKTHTLSQCSRLAISALVAANADSCHLEVCAIELYGKVQNDLLDASNTRVMVAETLQASSTFARATLRTVSSADELLSHVEAAWTQRITRGTEKNPHSSRSHALIRIICRSKLDANATSGVLQLVDLAGSERAADHSPAQAQARMAETVAINTSLMTLKQCIRARTSPAPSANGAPPHIPFRSSKLTLALKEAFDLYARQPTHTVFIATASPDLVDQPATLNTLRYAAALVAAPHARIHLQPDPQGRNIFFWTPARLAEWILKYASPFITPANIEALVQGQDGAAFARVPEQQFYARFADATAAGKLEGKAEAKAKEVYLKWWRLVIASRTISQKALADEWKKRHAAKLAHEAEEEGRDAEVQRLLRLEAVAKAPEGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIU3</accession>
    <name>W3VIU3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238168_0_0_1"/>
    <dbReference type="OrthoDB" id="2554322at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1499"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1400"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1502"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1640"/>
            <end position="1651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1750" mass="185138" checksum="1FB9ED272B22A05A" modified="2014-03-19" version="1">MQSAPSGSRHSLGLGGPSDLTAKRKSLHRTSSQPRKPPTRIVVAEGGSEFVLETPPRRPSASTSSQAVTRTGTASEQLLATSAPHAPARTQSSAAPRTLSTSLTPPRTKPIDRPYRPPPSSSARFYERQQQLWQLQHAAPGEPSNQLYMPSSSYLPSIPGVRHSPTEPAISSDPLSPHLLQPGPSNQHHARYTESVPHSNQAWSAAASSISSRTRSSSIGGISASDDGIHQTRARAGSDASSFTRSRITNGYMSQTDEESHDEPTLRTGPTHSFLDAPSTRTEPPSRRVPLAVAPTLSDLDDTNDVDWDTELGISADSPTDPLRLPLPPLSHRLAHAPADVDTHTPAHDHESVNSQIVVSSVAAPMASDSSLMSPLSVDLKGIRVTSNVSENWDDDFLFQNDEDPAEDATTRDTIRSSADAAHVSTSSGARDKPALHRVTPDHPDSDDDEDVENWDDAFAWNAEPSLTPSPSNSSSIANLRHYPALALALPGTNSQILRGNATSSSKPPTKGSAKPQKRWSDSSSASDVTNLSLRLAAQSDVDSFDSRASCDSGHRHASASHPKATRPSALKLASTPRSANLDLNHGSDASGDDTETETPSRDLDSSLVSLVSRQSRPARRSLGAALGFKTQVRPPTREADVKSPITPHTAGKDSIDSTAIKAHRRTSSRPKLGALQRLSLSRSRVSVADTSNASIDDISLAIQPAQHMYMDAANLSQASLISQKSASSARSSRSASVSSLAKSYAAMRSSSFRRLLGRGTPNKSASLAESDAILRAPASPSRFRSDNRMQTELQAGSPADRSIGSAESKAMSPPSNWLGMRRSSEVTPTRPRVRDIRRSSDGRGPTSSVRPSEAAHSHLVSRPSTSKHDRPAVPDAGQTAQTKAPSDTSYAGLHRDFSSSNTLRADSGQHDTQPLLAFVEPWARTDATSDASSRATAAAKDGSATFLYPRQGESMSRGIGDSASASRSVSASTAHSHTSAESLYGYRMKNQASASSGADAPDSETSYGTSVGSSPGLSQLSSSGWLSHAKYGTVSSVDTRTTSWSQSHDRYHWSHGQEDADNSCADSNVQASPGSLNKTLEGTPPRAARGTRLLSAPDTPTSPPVRAASWSTDTSLGKSAVAPSHTSTSRGGRHVSTAQAASSADERAAIAPTESAAFPSVGSSRPRHAARRNSLSDLKIPSRISKAQTGIRNNINLVRDFAKGIEELKALKTSYLDRREHSAPMALGAEDGVQNWLECADVLIDLGQGRSDADSAAHVDTLTHTPLSVRVDSRRTTVSDASSFLGPRSPLEDAGSRKSSISGASGYRSTSGASQTALSTASSADTGRSVDAQREIDILSAILGGTKIASPPRVEARSHGRFKSETYARNGHGHPNNQNPGKAVAAVSSSDLNTGRSELAPHDEVERQQRGLKNDGGQRPKTQTFNTAPASSDPNSSLELGLNLDGVDVGDANRSAKRRIRSASRAGLQGLRELLKVFKSAGPVEGVSTPPSKLEAVSLADESNGQQSIDADAGTPTTTKQKRRSLTLKRRSFLRSKPSLEVIRAKSDVGGEADAMPPVPSGNDGALLGRSTVQEQSPSRRDTRNNVASSTPTATAASSSSKASRRVSLQSSWNTTQRRSIDGVQISQSSSRPASALRQRSDSKTAKRAEAAMAGQDRGSAPKLRLPEEAGLAVDPRRASTSVDVVLQRTEQPVRSQSALESPTLATPMVPKLALRPEAMPGLLVYVQATKQHLQAAIDQLGPPISSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIY6</accession>
    <name>W3VIY6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIY6"/>
    <dbReference type="HOGENOM" id="CLU_015590_3_0_1"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="3">
        <location>
            <begin position="423"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="689" mass="77624" checksum="B909A4C5E0D4AEC1" modified="2014-03-19" version="1">MDARDSSDLGSGHTKGSHHNRPHIAGILPGSWKLTHSFRTRQWYPFSVRQATSDRVGWQTLSDPGLLEPSFLPALGHRTYFASSDCIHTQQQGADERLVKQDEMPVATQVAFKPLNPPKVGDNGYVEPKPGHSEVLKKGSAPFGCRTLDSDVRIDHDVEIVVRDGCRLYADIYRPATDEKNVPIIVSWSPYGKKYSAIDMIFNVCLWRCCIRDEDVSGLEKFEGLDPAWWVARGYAIASVDARGAGNSDGDTLVLGSQEAEDIHDVIEKLAKLPWCNGNVGMAGNSYLAISQWHAAAQNPPSLKAIAPWEGSGDIFREQFCRGGWFNMSNFDLITTLVIKGHHGVEDFAEMHRRSPLANAFWNDKRVDMTKINIPCFITGSDFSQIHTMGAVRGWMQVNTDKKWIKWSGYQEWFELYSCPESNLFFDKYLKNIDNDWEKTPKVRWATLPFGDRDVKHDIVLEDFPVPNTDYRTFYLGPNESLSETAPKEAGTSSHNSEERFSISKFRHTFKEATRLIGLPKAELYMSCDALDDLVVFVQLRKLDVNGKELSQLQFPLSRAPVKSIDDMQPKEKQSLSVHNGSIGILRASQRKIDAARSLHPQFPFHPHDEVWKVPRGEIVKLDIGIWAMGVDYDAGESIQVDVLGQWPGFDEVAAFSKPRPESERNKGTHVIHFGPDHPSHVILPFVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJB6</accession>
    <name>W3VJB6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJB6"/>
    <dbReference type="HOGENOM" id="CLU_1349427_0_0_1"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="203" mass="22703" checksum="82388BEF90618DE4" modified="2014-03-19" version="1">MPSQKTFRTKVKLAKAQKQNRQRVVDRSSRHSVDKPSRASPIRNTRRIIAFASPSPAQRLTRCSYASLYTLAARRMLATKPSIALRPMLASLASVLCIDAIDRLASLRRTLDPKPFSSVSARVRPNIAHAHLLDKLAHLNPTSHARANPASPLLPPPPPPPLLPLLPLPPLLPLLLLLLLLLADNKIQYNAKRRHWRRTKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJE1</accession>
    <name>W3VJE1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJE1"/>
    <dbReference type="HOGENOM" id="CLU_051399_0_0_1"/>
    <dbReference type="OrthoDB" id="2553216at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="441" mass="49585" checksum="99D72B336F64CA6E" modified="2014-03-19" version="1">MSAISRLLRWAPCFWAISKVANSSGQVQRSQVFHPQFPSYERNGPLDVLQSLSFSARTVVHNAHIARAAPPPSVPRGLEANGIIGRNVLPRWLPSWLRHNRPEVHMGWRWENPPFSVVLKLHNLYQRASSRILTLISQSTNARIPRELEHAVLLSLVRSTRRFGADVSVETRLVCKQWDQDLRRAYWKRRWLNIRPTVASWGKVGERLRLLFEQAPLIHKVKLDNVLTDIVPTPSVPAVQKCPELGRLAQCQIKEIKVGRLDMLNEVILKCMLSSHQGRLRHFAFRAKDAVLFRARRSIFAKSNLHMPKLRKITIDISTSPNDDLADDVHGSMAAHLAGELAGGGRDAKSKKMEVTIFCMPDVPDPSRPFISTAHLTLARSLVTLVNTIMQDRHITVLVSFEGPLASQAQSTISDIVAWAETNDVRLINTPAPNNAARSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJG5</accession>
    <name>W3VJG5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJG5"/>
    <dbReference type="HOGENOM" id="CLU_719866_0_0_1"/>
    <dbReference type="OrthoDB" id="10261960at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833239" evidence="1">
        <location>
            <begin position="22"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="384" mass="41987" checksum="5FD55BD037B1E9F5" modified="2014-03-19" version="1">MHFNTFSVAVLALLSLAGAKADDKISTAGLVVDDKQVASYCAIPVKPEFKEVEFVCFTLKGDIQKQMTNPNRLKGFVNKAGNAFVVLGQSGAQSFSIGDKHAVLHPIDAPYCRKVEVTSGGPESGATATAQKCPGNRLSIAFVQSHSSSLHLSAFLRVYKLWLERVHDVHPTGLYSRTADHYHLAARRMCGTWRKLEHVLYRMANEKLLPHLCPKDPLKQTYTAMTFNKATALALFGLLALIGARADGLSADQREFNPPFTPIPGVTINNDEVGRYCILGQRDTPKGYACFSLLGNIRGRMIEHQNLTGFMTEAGEAFVLIDNGATQSFATDVDHVTVTPSKQAHCLRLTVERQKAPGDKEARMTSTSCPASPAFHLADKWTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJU7</accession>
    <name>W3VJU7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJU7"/>
    <dbReference type="HOGENOM" id="CLU_017718_8_0_1"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="22"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="379" mass="43690" checksum="6427BDC9CDAB5319" modified="2014-03-19" version="1">MASNGIGIANLPNQRHKIVAKAGGHFTLMVVGESGVGKTTLINTLFSTELATGKDHSRRHTKQLDKTVEIDIIKAELEEKQFKVKLTVIDTPGFGDYVNNRDSWTPIVDFIDDQHELYMRQEQQPERREKTDLRVHACLYFIRPTGHTLKPLDIETMKRLGTRVNLIPVVAKADTLTQADLATFKQRIREVIATQNIRTYSPPLEVDDAASAEHAKQLMSAMPFSIIGSTEDVRAPDGRVVKGREYLWGVAEVENEEHCDFKKLRSLLIRTHMLDLIHTTEEQHYEHYRQAQMETRKFGEPKVKKLDNPKFKEEEEMLRKRFTEQVKLEEARFRQWEQHLIAERDRLNKDLETAHSTVKALEAELDALQNGYGRGSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK03</accession>
    <name>W3VK03_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK03"/>
    <dbReference type="HOGENOM" id="CLU_150186_0_0_1"/>
    <dbReference type="OrthoDB" id="2556292at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="119" mass="12870" checksum="4D6B357ACB6D8CF0" modified="2014-03-19" version="1">MVEPGRTCACTPRSLLVPAGGVKTLDPSQRVSSKELEAKDREWRRQQEQSSQPHRSTPPTGSNDSQSTVTANGSQSHSSERPSGRAGSLNVEPRTTKTSASSLSDWIGRKRTQPPSVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK35</accession>
    <name>W3VK35_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK35"/>
    <dbReference type="HOGENOM" id="CLU_006647_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="400"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="601"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="694"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="742" mass="76481" checksum="85984AF807F5DE96" modified="2014-03-19" version="1">MVDDPNTDELIRWSPDGASFFVPNHVRFGDEVLPRFFKHNRFSSFVRQLNMYGFHKVPHLQQGALKHDSPQESELWEFSNPHFHRDHPDWLAKVQRKKGPRDDKDNQAERESGAATTGQELMHAGALMRTDFGAKDAAGEGGALQLASVLNAINAIKNAQTSISSDLRHLQNSNQNLWQEAVESRQRAKRQQETINKILRFLAGVFGNQDDPETPVPGKKGVSAKGRGGAGGRRVGVRPQARNKGRLMIEDGKSSPVRGLEGLELPADEEEIEEMPSHLRFQEASSSGDSPKGNSPSTNQGGSRFTQIGSPPSNSMAADLSGHLNEAVSTPGGSRRLSSQASNQVLNALASGEGNAWLASLFGASLANQGSKSTGPASGGGLKLDPHMVAALQQALASAGSGAQSGSSNDGGNDYFGGGSTDAADLSSRFSTFPNSTASSKGSASQPVDSSSSGQGLGLDADALARIAGISQALIQSPARQNFGTAAGGYVTSPTKSSGAGVPLDGGDDSSNQQLALSLSRATRDLNNTSQDVDHVQNSINSLIEGLQTNPNLLQGLTSQPPASVDVPASSASMWQQPVDPANAFGAGMLGNSAPFDAGMAYGPTGTTPPPSSAVGAGTGAPPGGMEPDFDVDSFLSQFVDSSQAPGGGVASPSAQTFGESPSFAFSPATTAAFLHGAAGPPVGEAAGIYAAETGSGSSAASTPPEKGVAGKKRKPSAGAVGAAVQDVDMAPRPQKKSAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKM1</accession>
    <name>W3VKM1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKM1"/>
    <dbReference type="HOGENOM" id="CLU_022565_0_0_1"/>
    <dbReference type="OrthoDB" id="3350153at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833058" evidence="3">
        <location>
            <begin position="24"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="559" mass="57650" checksum="3D5C8C73B1B43E61" modified="2014-03-19" version="1">MWLASVLLAAVAACLGLPASTLAFPLNYTVSQQCTPLNVTWKAVPEAFPYTVWILANHGFVQTYRINSDYQPGADHITFQYVVPPPSAGFTSYTVAVGDSRGDGNTTQTLGIATPSGSSSNCGAYTGSSAFTYAADPANGTMIQCGAVKVYNIGDRGTRPFTISFVPLGGAPVSVQVPQLYTLNISSFVYQTLVPFAQGTQFQTVVGDASGHGSGGASEIFTVGPSTFTPACLASDYRLPNQLSTPLPIASSVAMFNNLGGAIPTDAAAQKSSSGHPTGAIAGGAIGGAIALGAVIGVLVAFLLYRKRKKTKRDAARSEEVRFVDLDGDDDDDIWGTADPRRDAARPAGRSNDGGRPAGQSYTVSPFVYDPRHDGASSDGRYGQSLEMTSPSSANPSYGELLSAAGLSSAAVSPMDDYPSRAGNASIHSHSSQNPFSSRAAGIERSGTSGSGGDGSHPYATGAGMGIHSASSLPSKAQMSAQQERRDNRAQRRVVQHSDGGPLPQPSSDTEDEEVVDELPPEYGGWLQNNANASGSGGAPPPTSAGSARVAGDYACAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKR3</accession>
    <name>W3VKR3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKR3"/>
    <dbReference type="HOGENOM" id="CLU_059211_1_1_1"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="108"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="256" mass="28185" checksum="CE48D0BC6217BB4B" modified="2014-03-19" version="1">MSLRFASMRLVPPASVLPHLERSAANVVRSNTLRTARLASTVRPISLRLSNSTPAQLGLRSLSTSRPTLLETSLRRSSQSGKSTKEQAEQAEEADSDAPPPKASLRERLKFLTRRYGWWALGVYLAASSVDFSLTFLAIHLLGADHIRSLEAQVRSSLGLEQRHDDPDSQDGKKQSGSSTIWTEAVLAYTIHKTLLLPVRVAFTAAVTPSFVKWLVKMGWARANHQVKAQVGRKAADKAIQDVIKRNAAKETTKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKT5</accession>
    <name>W3VKT5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKT5"/>
    <dbReference type="HOGENOM" id="CLU_014798_3_1_1"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="291"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="665" mass="69482" checksum="C84A4B0710BF6699" modified="2014-03-19" version="1">MEFSSLKEQRHQAHDAAEARAAAAAASVDTDDSPRQPGSSSSRTTQSTSGANGSRSGTADPVSESPFGKAMADPDRAQPERIHSQPLEDGSLPQPDHPEGAQSARASTDATAVGAEAEAEAEEPPMRPHNLLTATEILQGAPGSASPFAPAPILRLNAIRISGAGRALRPSFLASLCRPYLDPTLSTQNADVLPLNTLYYGSRTSHVLPGQPTTLASVLALTSSLAGDLDKLDVFRNIEASLAPSVFPGASEEDVDVILACGRPKGRVFLKSSTDVGNGEGSASVQGRIRNVFGGAETLQGSATFGTRTRQAFNVEFGAPLAGNPDMSYRLAAFSHDRDLSAFASVSEAIRGVRASINSSSTSEPQGVINPTGAEEDEGMATTQHEFAYEASLRELARVRPYASVAVRKMAAAPSVKSALSWTWLRDSRDSVVLPSRGSRMRTLLEYAGLGGDANHVKAEFEASTGRHLSPLAWLFPSTASSAEVPTSLMGSAAVGKEEGDVVGEVAQGLHPIFTTLTLRTGVVHALGSSAPHLSDRFQLGGPTSVRMFRHSSLGPKNGQDSLGGDVFWSVGLSMFSPIPKKPHWPLMLHAFANAGQLAQLPTAAASSRVGACKELAQPSTAAGVGLVYTQGQLRVELNAGVPLTARRGDGMAKGLELGIGIDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL98</accession>
    <name>W3VL98_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL98"/>
    <dbReference type="HOGENOM" id="CLU_008770_3_0_1"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16014">
        <property type="entry name" value="PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="83628" checksum="9D678F35C319E3CD" modified="2014-03-19" version="1">MVFVIRAIPPSLLVGRDGPEKSPRVARCSTFRQWASQRSLYRYCHFLPVVQATAESVQKRDRAPVAAAVEMDLTPPAQLAAAVVSTGTHGQLVNVPSPCTSVQMSFLACCSPLVFIPVPQRPRPRSAGSLAPMVWLKKASWIALLAFVAAELPSWAAAAAKDITQIEHIVLFMQENRAFDHYFGTAAGVRGFGDPNVVISKDTNKPSFYNPVSVATTEKGSPAPPAGVDHLLPWYINHQGGNSNDRWQCSVAGSNGWEQNHAAYDNGNVNKWATKNTPYSLAYYKREDIPLHFAVAEGWTMADNYHESVITSTSPNRISWLAGTMGIDQARNNLGGPAIDNSETPGCETADDGSTYSCYPYKWKTLPEYLEQVGISWQLYQDTDNFDDNPLAWFHQFQQAPNNSALAQKGMAFKGLERFYSDAEQGKLPQVSFIIGPTELSEHPPYGPLDGAWLQKKVVDAVTKGEKYGSTALIISYDETGGWADHVMADFPSISEAPNEWIIDPYNKTLGQQPVGPGFRVPFYVVSPFTRSGGVFSEPAAHESQILFVEQWAKAIGKPFEQESMTAWRRQSLSDLTSMFDFSRSDTSVPELPEVRQATQDRNGQYNGASTCKAKYGGGQPDVPYTQKDDDAWVLEHGFKHVRGIPSEGHFYVFEKANHALAWDAKTGSLSVSTATPDHADATQRFVVHAAGAGPKNDAFYLSPAAQPSQFVAANAKLTTDRSKAAQFVFEDARNGKGYTVSARGAKLPDGFNGSGVSIYSVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLC5</accession>
    <name>W3VLC5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLC5"/>
    <dbReference type="HOGENOM" id="CLU_352735_0_0_1"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834656" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="538"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="958" mass="100946" checksum="21FF9C3E864411BE" modified="2014-03-19" version="1">MVNLALKLSVVVQAALLLLVLQHATTPANAFFGRGRPAEFNSTDLVSRYADMETSNPVMQRAANAQASSKGVPAYENSKDVNGDDDDDEEYDEEYDELEIITSFEPEQDKLEADILRKRGGPTPCPAQHTQRQRRSLETPRPHHKREPEPEPKAHHKEHKVTKTIHQTVHRRCTRNARRAPKPTPQVKPKQFKQRFVSNFQPPTGYRYSWGIDASRVSYGTFSGQYISRTTIFGASAVGQSEVEICSARCENTNGCGFFHPVQMNGGSEGAVICVLYTVKQSKSAATWTSGAGSAGGSVAFSYGFTRNAGPAAGVAKFQAPSGYLFSWGIEGSRVSYGPSTGQYISRSTIVGATVVGQNELATCGARCNDVKGCGFVHPIQMSGGSEGAVICAFYTVEQAKSAATWTKGAGSAGGTVKLSYGLVRNAGPSPGNPAATTSVKTTSTTPKPTTSSTSSRATTTSTSTTPKPTTSSTSSTSTRSSTSSTSTRSSTSSTFTRTSTSTTSTSTSTSSSKTTSSSSSSSSSTTSSSSSSTSSSTSSTVTPTPTPKVYSLMANYRGANFYDNMYFFTFKDPTNGMVDYIGRDEASSLGMVKTTSGGQVYMGYATTRIYPPAPTTTSTSSSSTSTSTSASSSTSTRAAGRRAISTSSSSTSTSTSTSSSSASSSTGSFGAQAVTTSSSISGSSSTSSSTSSAAATSSAAPIPYMKSVRVSSYDTFTTGVFILDASHMPVGCGVWPAWWTVPTNPAGGWPNGGEIDIVEGISFTSQNTYSVHTAPGCRVNATTNSQLGKYQLTNITMATNCASAETGNQGCGVQSSLRNDYGVGYNNNGGGIHAMVWDKDEGIKAWFFPRSATPADIIAGTPDPTGWGTPQGSWPAQSCDPTTFFFNHVSVFSNTICGDWAGDKTLWNNAWNGQAQSCAQMTGYPTCQSYVQSKDVDFSQAYWLINSVKIYQTERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLE5</accession>
    <name>W3VLE5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLE5"/>
    <dbReference type="HOGENOM" id="CLU_2172720_0_0_1"/>
    <dbReference type="OrthoDB" id="2556698at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="109" mass="11773" checksum="A01343C2B94D0D2B" modified="2014-03-19" version="1">MTMHVVADIHISTSASSAPLPPSALPLDNATHLTPSTQLRVPVHADGHALNNLADSIDSTRAHLNTILTTWKDWAGKEAAPAGTLQLKQNVDGEQDQDEDQDEDQEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLP7</accession>
    <name>W3VLP7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLP7"/>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_1"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="44"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="13">
        <location>
            <begin position="419"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="590" mass="65207" checksum="12338EC6E9818EF1" modified="2014-03-19" version="1">MSAFSLRAYRASRSCVSCVRSQRFYSTSQSAASPTPSKETQRARLRFAPSPTGYLHLGGLRTALFNHLYARALGGKWILRIEDTDQTRLVPGSVAALQETLEWAKLDYDEGPTAGGSHGPYVQSERLDLYRHYAEKLIADGKAYRDFRAEAAASPDADATRTKHIPLRDDYIAPTEAEAKHLISLGKPHVVRLRAPTGSLDHHDLVYGELHFPADPQRHGTEDPILLKSNGWPTYHLANVVDDHEMRITHVLRGEEWLPSLPKHLWLYEALGLTPPQFAHLPLLVNADGTKLSKRTGDVRVESYRDKGFEPEALNNFLGLMGYNNLAYHSANLGAGATHTKAKAEGEQDATGYDVLTMAEMVRGFDIAHVNRSRATVDLAKLYYLNARHLALKLDDKQPGGGRDEIVAKARPKLVEAFPEVAERLQGDSELVEQVVVLAKGTSATLYDVPESAAPLFRQPDFGLAEVQELFARNAMVNRHFDAAVREAQRQFETLSSSHSWTREGIHDVIARLPKLLSDAAPPSTDAKTAKTKVKKAAILAPLRFAISARERGPPLADLFLFLGADESLNRLQNAIAALEVHQLRASSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLU3</accession>
    <name>W3VLU3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLU3"/>
    <dbReference type="HOGENOM" id="CLU_309978_0_0_1"/>
    <dbReference type="OrthoDB" id="2556718at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="861" mass="92792" checksum="EA8E1FC39AE33387" modified="2014-03-19" version="1">MSDTRSSSASTSHSDETITPYRNARARGHPDVSDAITWLEASEATTACSTVTAPPKQADFELKRKSLKRLPIPESFRSIPQKDEEKPGVGVSLGFGVQPNDDTDQDNDFPQSPGHSPLSRFDVRPSQHSPVVLRRFSLSPPSLALPARLRRKQSRVRSCSDPFERRQLHPSPPPVSVPLDVDRQSIAPLQIVGLVGHKLEPEDLISPNAVLGRKRIKRKPIPTSLFSDAVQTSDTVIAEFTRSLSCPDGLSPPLLPEASPGAEIEAGNKLGLFSEEEPPEAQPRTFTSTVDSELAAVQGSSLELAARSSPRAGRLRRATRSVSESHDRAKSALRSNDTKLRASLDATAGLGFGPQSLDTNPAGSYSGETEGALVERSWSPSPPTRSSSEFTELDHGASQILRRVSRTRTGEMRSVYLSSPTRNSRPGAELAAMSAVVPDEGEGIEVLKTPDPAASGAFGHPMTSSLILAPTSQAEWRGSLATRARSSSETSMASLLVLQQHIQQRNHQRQFAPPIADPHPLPELERLRSREPSVEEQQHVVDARRMQARRKAEGVGSGEQKLIRQYGAMRIRNCTGEFAADDHDDQCQLAYLLGDEAVTAVQQDAKGDMRLRHMFSTPSLVSASMVESEGDAGSSAMPLRQRRAKPPISIALHQQTTDEQAKPGAVVKKRSSRSTVLSPVSVHSPPPCPPPTTPLPQLPTPRSAPIIPLGGPRRGLITKRSFTRSNSTPVSPFSPVAPLRPYQHAQTQSQGQNIVSAESTAQTWSEFSPPPSSLLTPPLTGMPSLVFDHQPNTPASASATTPVKQTPLANRHKFDSLLAFLSSSEAQHATNDSPSKTGTEHSERRLTASPGSAAVVYGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM24</accession>
    <name>W3VM24_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulatory protein alcR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM24"/>
    <dbReference type="HOGENOM" id="CLU_301501_0_0_1"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="934"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="108665" checksum="22FCE29DFEC0B009" modified="2014-03-19" version="1">MSTSTQDSQTTTVPPAAALDPAMNAANDDTAAGAARSRKKMYKNCDRCRQAKRACSAQYVSIAEALANKVACKNCKKKGEVCTFNSLINSFGGIPLAGLTGAAFAESLQETSNGLPSENTSAAASNDMNIDETLASEPESSRAAERRRDSQSSIDNVNAVFELLNSCDDLVQPPAKRRKASALDSQQMFSSYAGFVQPVSNAASNSLVLSRAQSPFAEDESDTSVFDILGFQIWGSAPSVRLAQTADRQHLNSDLLNVYEGAAESAFRVWVTDATTPYLLCADSLSSTSAAMSLNKKVTLLDHASKRIFKADNASRNVEKRVSEAYHAVLLAYAAQWPRHRNSQTASRAEWKPDEARIRLSLWKQARDKLMDAADAWSFRIVFALILFAWTEKPREVPDDEAWGSDNEPPAQLHEVPSLDENSALDSSSWQINAEASTMMLATAMRKLKAFRLKIQQLRRKGIDLWSTEEPGLEASQVAHRRAEATLLENTYHNLYWFGCMMDTELSVLRKYDAVIGDEDSDLTDQLLSPQRATSLRNETESFATGASATRKPVRKIWDEVIPANSQKNRHTFAKSWPCSEEDAKRTLAYATPIKVLLFRHVGRLQSSYWRQASSEQIERQITHVLSVVRHWDETFAPFFASCIAHHHELPPSIQSWHVITATKWNLAAILLVELVQTIDRSAASSDPFQNTDEIFAALRTKVCLNTAALIDAIQRSSLARVPSAESPFEFIHATDSTVLHSDPWPEISVHGFACVAKCEIKQFAQLAARSAWAELEAAEQRVHKCIWALDQLSNRSTMAVDASAEVAKLLEVHSPFKQQQRQQQLQMHLARDEDARSQSMDASVAAQTPAIEAFLAGGGSVAPPAPMPSAFTDEVWASCLQILSESEPREAAAGTDETPDAGSSSLLWPDLGVPSTSSMPLADDTDSASSEHSLSPTYTSSTVTSSMGAPIDSLSLPATAPYANVFPDVKDHDAIHPTLDSFPNAFQFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM26</accession>
    <name>W3VM26_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM26"/>
    <dbReference type="HOGENOM" id="CLU_037990_6_1_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30705" checksum="DABA867EF1543A3E" modified="2014-03-19" version="1">MKSLPAELHAKPAAPATLFQYIFQNIFPVIMLVRLYVSGLPGAIVEQLRNPNPINLINPLHWKQLAFNHGFSSILAVADEMYKDMKTPLLQGAYGRVLEVGAGAGNSVGYYDQSKIERLFCLEPCAPLREKLIARLERVGLAKKTTVIPVGLDAQSRHALLEAGIEPESLDTIVLFQVLCSVPNPKAHLEFLQSLLKPGGQVIVFEHVGSKHGFTRTIQNIWNPIWSFNFGGCDINRDSGDWLRDIGGWKQIDLKRPVHETTAEFLPHDIGRLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM40</accession>
    <name>W3VM40_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_03962</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM40"/>
    <dbReference type="HOGENOM" id="CLU_050424_1_0_1"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="344" mass="37804" checksum="8427CEB4AEF5F275" modified="2014-03-19" version="1">MGFSFGSYSSICDEVAMVVCPLLGNSGLGLEPVCYSRNVEINKTIIFQPATCFIHIAALVMTAIMVYHIRSKYTAVGRKEIVLFFYLYAISEVLVIFLDSAIVPTYSAAYLYLTAVYVGLKTAIFWCLLINGFVGFQFAEDGTPKSLWFLRLSSVVLFGIGMFVSIATFKGIAGMSPTKQTGLWIVELIFPLACVLIYTVSQVLLVLRTLDDRWPLGDITFGLFFFAAGLILMYGFGEEVCRAVKHYIDGTFFGTLCMLLAVMMVYKYWDSITKEDLEFSVGSKQAVWEVKDAGFGTASSEGDGTMLGAGSAMTHDSFRGTSPSRFQGPGKSNMAYPPVGNYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VME5</accession>
    <name>W3VME5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VME5"/>
    <dbReference type="HOGENOM" id="CLU_354552_0_0_1"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="945" mass="103897" checksum="D562951D7441C24A" modified="2014-03-19" version="1">MTASNNRPTFGAGAESVAAQPNIARTAPPYKRQRVELLSDPTRAQSSRMQTEAGASPKRMHIASPADARPPARVAVATPSSPSTPGHRRPPPLATKPPQPPSSASASRPGPLPAVPARKRRFTRSRSGCATCRVRKIKCDETRPHCHRCLEDDRQCEYFRSAGSARTEAEVKSQAEPSGADLHPAAPAGKPARLSQHQQPHHSPRQTSVRHIRPGPAHQLSSIPTGDASTSGDITSPKHLDDWLDLLCASIGNDIQHTSGSATADASQPVAKRDDQLSDTSRQSTAQGSAPSVSDSQSDRSASRDRLKARYGRPTAAASAIADHTLAFGSAEARSPNWLDDDWLSTWTASPSGPTGIQHTFDGASATPVSASTTAARPGLQHIPEAELQRRIRALCVTRIQLESVSFFFNTTARCFHLLSADTNVWRIFFAQLAAESPMVLDLAGCLGLTHLSLAQDDRKKGLAHAHFSRCKTEWDAFVGPLHTPELIALAAEQINSAHRALELLAGTILIAHVEQFSRGFATSSRAYTALAITVIRQVLAGAPNGTPASWWVNDLDQGPASAFRFFVRILLWWETMSRTMGPASEQGDVLDIFEHVYRWDESDSRQQDPIECSTQCVVGWPLDLLEAVERINRLSAVPEIVAFVPPPASSVPLVMPSGSLSHALEDHVPLETQLQIDAIESQIRLSRPMPLTQDDSLAAELRYLIFECLQSASLVYFCRTLLKSTDAAWFEIDKVTRFLERKQQRLRTSGEVKSAGPSCPQDPTGDLQVAHAMETRGKWWIRAPDGALIWAYFQCASEIFGELDASLESSALVVSIGGHRDRRYQFGRGEPVKLALGSDIVIGADAYDSFARSRSERRQRCRGSLLLWEKFDEIQCLFLCRQLLKAVWDGRDLYEHETRHRMRLSKSASSHASIDAPQDIGRYDQATELAHICRQRRWRQPLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMI2</accession>
    <name>W3VMI2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMI2"/>
    <dbReference type="HOGENOM" id="CLU_026719_0_0_1"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="502" mass="55948" checksum="28FCE4F5AF5B4F16" modified="2014-03-19" version="1">MSTTEVETLVIGAGPTGLGAAKRLNQLNHGPWLLIDANKEAGGLASTDTTDEGFLFDVGGHVIFSHYQYFDDMIHEALPNADDWYEHQRVSYVRSKNVWVPYPYQNNISVLPVQEQVKCIEGMIDAAEERVRAKEAPQNFDEWILRMMGQGLADLFMRPYNFKVWAVPTTMMQCKWLGERVAAPSLKLVVSNTLNKKVAGNWGPNATFKFPARDGTGGIWKAVARTLPQDKLVFNKRVASVDAAAHTVQLTDGSSIKYKHLISTMQLDFLIDNVKLPAEENHAQLKAAVKEGLVSSSTHVIGIGIRGKLPPRIGDKCWLYFPEDDCPFYRATIFSNYSPYNCPQADVKLPTLQYADPSKGTPSSDAKEGPYWSLMMEVSESHLKPVDAQTILAETIQGCINTQLINADDEIVSTYHRKFTPGYPTPSLGRDAALATLLPALEKHDIYSRGRFGSWKYEVGNQDHSSALGWEAVNRALLGTPELTLLNPDWVNGRRNHELRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMM1</accession>
    <name>W3VMM1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">30S ribosomal protein S18, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02557</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMM1"/>
    <dbReference type="HOGENOM" id="CLU_110814_1_0_1"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000017">
        <property type="entry name" value="Related to 30s ribosomal protein s18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_bS18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="207" mass="22037" checksum="3F2E305D5B09A8F9" modified="2014-03-19" version="1">MKVATTFISRACSASSSRSGAMQPLRRFATSAPASNSGSGSALDELSSSIEQLARNRAAAAPSASGAVHNPRSPTPVRDRQTVSGRAFMNGHYYNPATLSYTSITERPARLARPLLGPTRKEAEQQDMIHINGLKPGKPSLHDDSYKNAAILANFVSEMGKIMPRASTGLTRKSQRQVGKAVRRARSMGLLPVMSRGGTRASGAGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMM9</accession>
    <name>W3VMM9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMM9"/>
    <dbReference type="HOGENOM" id="CLU_1215225_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="228" mass="25381" checksum="C6E9210412CB4360" modified="2014-03-19" version="1">MRVAIWLYCLVIPPPWHSLRRDYCKACSQPTAEANEASDARLRSTRLHLPGPPREMKWAPCRRKVKLLAPDDGAIQAQRGAQRPHICIHNQHASLQFSQPTIPIVGDQLAGERVLLETIVASPLREARKGPSGCAGFYGLVQAAWAGVVMKLGDKAPQRPSRPEHLPLSPLSSQRRFRRHLHASGSDASSLRLGRGSLNIGTDKLKLSWRSYRAGQIKFGRSHRDAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMU7</accession>
    <name>W3VMU7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMU7"/>
    <dbReference type="HOGENOM" id="CLU_350257_0_0_1"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="804" mass="85931" checksum="F85567E61BDA4BD0" modified="2014-03-19" version="1">MKIQGPDRLAWLAGWEPHEHPYKTNLHRLHIRYTSYRNKLIGRRRIQSRSSLARTIDATHLRDRSASFSSAQPIPGPIQPHKIKLKLVAAEPNMRKKRGLSRPLRSGLRASLPSASEALQVNQGRVSVLLGIDGFGRRSARSSASPILRFLACSMRLPPRLAETAGSARSASASVAATPSQPTQPSPVLLRAPAAATFKWLRRPPRLTAYARPADRAFPCTTVALALKANAPCFAANLASPALALPRLSGRSPPLALRDLRGASVVCAQITPAPAARDRAPLPGLIQHRCAIVAYPSSDRQAVLAALSDVVTVSPNPDNQRNAGFSRHAHHPSYDPESSYTGLQPLPITEPPPMVPAKSPFEDRSLPPPPEVPAKASGTSMANKFANAFRRTNADDKAKKRAKDKRMNDEINKTAARTSRMDIIDRLDLSGINGSSMFHHDSPYDACAPHMNKGKRAPVGAFDPNVDPMTGLPRNAAGAKAGRTGRAGAGDALAADASPADEKAGARPGANAAGGRTRSSTAPLVPSLSMHAEGSTTELPIDEDIDADRDAEAERIWRSRQGYHTQPSNVPDSRYDVSNPNADVWGETAAAPPAPPAAGTTSAASSVLDMEAIMTGKKKPSRAQQDLDVGSASPFPEPNWDERAPAGADVPKRSKSLIKRIRSMRENPNVPPPEDGAVEMRDRRRRAAQHKHSPSTPPTAVGGQSSYDSRDSRAAADAAVSSGSYGRRTNRTVVTPNERDVVTPRAQHDDDVSYFAANADSRSGAPRSPAAEGSGLTRNGSLFNKLRRGQKSSPKSAERPAAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNH7</accession>
    <name>W3VNH7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-coumarate-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNH7"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="383"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="57398" checksum="5587F9CEE1A90A53" modified="2014-03-19" version="1">MYPIFVFAAEIAGLVTAPVNPALTVGELAKSLEQASVDVVLAHPSCQDNARAAWEQAKAAMGRLSVSASSSAATDGLYMFDDADELVIGAHGEPDLRAQLTDNELESYRVEDPAKETAFIMFSSGTSGSAKGVEITHSNVIHSVMALVATHDDYFGQKDVQVGFLPFYHIFGLIKLMHHPFYLGMKIVILPKFNLDLFCEKIQEYRATASLVVPPVLLQLAKSPVPEKYNMTSLKCVQCGAAPLSAELFELLEKRYPGMAVLNGYGLTESLPSVICSGPKELPNSKGAAGRIAPGVEVRLVSEEGHDVGQEQGREGNPGEVWLRGPTIMKGYLDNEDATRDAFTEDGWFKTGDVAIMRNTEIFIVDRIKDLIKFKGFQVSPAELEAVITSHPEVADVAVFGVWCPAQMTEVPRACIVPRDLALLNKPDECIELEKRVRTHMEKLVAAHKKIRGGIEWVATIPKSPSGKILRRLLRDEAAREAAKLDAQSQLRSTLVTSLSAVNANNNAKNDEEAKESIFSPVSPVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNH8</accession>
    <name>W3VNH8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alkaline phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNH8"/>
    <dbReference type="HOGENOM" id="CLU_015982_0_0_1"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF7">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834730" description="Alkaline phosphatase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase D N-terminal" evidence="3">
        <location>
            <begin position="111"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="221"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="71514" checksum="1C10F07225F124D6" modified="2014-03-19" version="1">MKNIVAPFAALVTALSVSVSALAPLERNLAYRSPSLSLSNGDGLGHDIEHIGAQIRKRAYDDYVTSKVEGKARRNNAKGKTEADFLVEKYDGDYGSDGRDAYKGKVSFPYGVAAGDPYPDSAILWTHPVPEDANTTLPVCLRYQTSRSESDWSKANLVDDSYAWTTSEVDYSFKVETSGLQPKTQYYYRFFSCHDNSVVSPVGSFKSIPDYNDDEVDSLKLAVFSCSNLPFGYFNAYRAAAARKNADYFVHVGDYIYEARGDGQKVAGENTYGDGRALNRVPEPDHEIDKDLQALHGSVAFFGIWDDHEVADNSYNHGTADGNNTDTGAVRGVRFTERKLAAVKAYYEWMPIRQVDTTDSLRIWRSFRYGKLADLFLLDTRNFDRDLTDVYWNTDAVAAISNDTDRSLMGGKQEQWLYSGLVNSESRGATWKIVAQQIIVNWQNYGTPSFMYNYDAWQGYRANRRRFFDTIVNNNVDNTVILAGDSHANWVYDTVPEDRLNTTAYDPTTGEGSIAVEFAGTAVSSPSSYGANLTQEKYLKRAQDLVTVNRNLQWAEGGTRGYFEIEFSKDECNAQFYGYINNTNPNAPEQLIAQFNVKKGANQLTRPINYGITPSSGALQSQAVDYSKQKWNGTAFVAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNK9</accession>
    <name>W3VNK9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNK9"/>
    <dbReference type="HOGENOM" id="CLU_2278648_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="102" mass="10809" checksum="F773B9D444438AD9" modified="2014-03-19" version="1">MHAVAAPCLEPRPLALLPAARASCVPCPASPASPASATARGAWSRPKRRRLVSTPPPSTSISISSAQPQNTQASQAAVSPPRYPKPRLRSWTPFLHLVLRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP40</accession>
    <name>W3VP40_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP40"/>
    <dbReference type="HOGENOM" id="CLU_1835985_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833268" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14623" checksum="93FF66B213231E2A" modified="2014-03-19" version="1">MSSNCLHLLTPSALAAAAAAATAAHRAATSPSLGYPLFAQVMIAEPLRLLPQTLLVATASRLKLHIATVARSMPRLWLSTPPILSMLCSCSALPMDAIVSTSMRIKTGQIAASPIPSHHHPSLSSPQLLFPLSSIESPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP47</accession>
    <name>W3VP47_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP47"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_7_1"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="344" mass="37918" checksum="533D756754713AF3" modified="2014-03-19" version="1">MAHQQGPAEASQHQRKGSCAEDVLLESDPELWSESLVYKGSLAGHKGWITAIATSQENPDLLLTASRDRTIIVWQLSRDDSNYGYPKRILHGHNHFVSDIVISSDGQFALSASWDKTLRLWDLNTGTTTRRFVGHTADVLSVSFSADNRQIVSGSRDRTIKLWNTLGECKFNITDDGHSEWVSCVRFSPNPQNPVIVSAGWDKVVKVWELSKCKLKTNHYGHTGYINTVTVSPDGSLCASGGKDGITMLWELSDGKHLYSLEAGDTVNALVFSPNRYWLCAATASCIKIFDLESKSIVDELKPEFTGVGKNSADPECLSLAWSADGQTLFAGYSDNIVRVFTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP50</accession>
    <name>W3VP50_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP50"/>
    <dbReference type="HOGENOM" id="CLU_024081_2_1_1"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="239"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="506" mass="55617" checksum="CB249F9C7658E50F" modified="2014-03-19" version="1">MSDPAPPSAPGHEPELWSFSAWFPPPYRVLLLASIGLLLFAANVHILHTKGIDLFALFRADEQEKRRQTGSNSFHRSTTGAATQYGSYHNTNRTPHEANGAILPTTQSTTATGQGGITTRPLVVFGAAQLAWALAGWASYRFYVDSLAGDPKGRHAQALQGFAVAGAAATLLWPGNLFFKPMRKAFGRALLLILTPSLSQPIPFSHVVLADILTSFAKVLGDVWLTACFLVPRKEHHTWWNGKGSIAVPLLISLPYAVRLRQCLSEYATAPSNTGGKNKRPLWNAAKYASAFPVIWLSAWYEADTHAASHEADWISRYTLWLLAVGVNSIFSFWWDVSNDWGLSLLLPANMGSLASVANNATNLHRRGVSYAPLPTDAVPMASMRADEKRTGLEVPSIAVAGPSGSGAAVGSHGRSLSTVERMLRPTPSLMFAAWMYQLAIVLDLGLRFLWSLKLSSHLHHLVEWQGGVFSFELLEIVRRSVWVLFRVEWEVVRRRESARPHVALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP97</accession>
    <name>W3VP97_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP97"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="346" mass="37704" checksum="B406EAC577ECC986" modified="2014-03-19" version="1">MRAFYLHKDIAPEELPSTLANDVPEPKCAPGSNEVLVDIHSAAFNFFDILAVQGKYQVKTPHPYVPGVEMAGIISKDSPIPEGCSFIPGKTRVFGAAQGAYGEKTKADYWQLMEVPEGISLEQAAGLFITWPTSYAALKFRANVQEDEWVLVHAGAGGVGICAIQIAKAMGARVIATAGSADKLRVCKEVGGADYAVNYRDKDWQDQVKKITEGHGVDVVYDPVGMIIPSLKVIAWNGRIIVVGFVAGTIEKVPANLILLKNVAVTGVHWGAYVRNEPDKIGETWEALLNMFATKKIVPTVFEHIYEGLDSVPEGLKDLAERKTWGKAIVRIRADPQFPPKGKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPD5</accession>
    <name>W3VPD5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03275</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPD5"/>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_1"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="45"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="390"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="222"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="83"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="509" mass="53659" checksum="213A0EB6E7CAC173" modified="2014-03-19" version="1">MISGLLSRSSVAAPARAFQSSTLPRVVSALPRVQSRGLATGAEPYDLVVIGGGPGGYVAAIKAAQLGLKTACVEKRGSLGGTCLNVGCIPSKAMLNNSHLYHQAQHDFKSRGIDVGSISLNLDTMLKAKSSAVTGLTKGIEGLFKKNKVDYLKGAGSFSSPTTVKVALNDGGETEVEAKNILIATGSEVTPFPGIEIDEKQIVSSTGALELQKVPEKMIVIGAGVIGLEMGSVWSRLGAKVEVVEFLTSVGGAGIDGEIAKSFKKTLEKQGLKFRMGTKVVDAEKKDGKVLLNVEDAKSGEKSQLDADVVLVAIGRRPVTNGLNLEAIGVEKDERGRIIVDDQYNTTCKGVKCIGDATFGPMLAHKAEEEGIAAVEIIKTGHGHVNYAAIPSVVYTHPEVAWVGKTEEDLKKEGVEYKTGKFPFLANSRAKTNADAEGTVKFLVEKETDKVLGVHIIGPNAGEMIASAVLAIEYQASAEDIARTCHAHPTLSEAFKEAAMASYSKAIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPJ0</accession>
    <name>W3VPJ0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPJ0"/>
    <dbReference type="HOGENOM" id="CLU_456495_0_0_1"/>
    <dbReference type="OrthoDB" id="3366002at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="537" mass="54200" checksum="61EABBA55F58FE82" modified="2014-03-19" version="1">MSAGTSPTTQPGGRPKKNSIGSWFSKKFGRRPSEAPLPSGDPSIARKGAAKDGRSRTSSAVAGANANADGQQSQFSSAFASNDAHALANTLTVPSNGGPAQARLTPPPQLDGIPTQEPLGAIDLPRSPRPDADVQPSGHGAGTMAPPSVPAKVSTEPIVDGDTHASAVPSDDLATNAAPAIPTAVVSDLVNPSTDAIAPTTDDESSFDGRDSIGNRTMDTSKSRASTKPTTLMSLDTREPAVLPTTHIAQGRRSGGDDSFGNPHRLSTGLREGSAIQFAPSAGSRSGSGQIASTNSAGETGSNFITVPSHSRPHPNNNPHPAAQPADNASILTLASSTAGMSLGGATSSRGHHHAPSLGGARSIGGSLMGDRRNSSDTAASLKALPPLSRRGSDESSRTRESVAASSTGQNSHQAMFVGVAAPGAPGDRVSLHRTPSQKTVATQMSVPLSTSASNAAINAYAKSEHTTNGSQLHLVTSSAAAQTTGETEADTAVTPGASPKTVDEAAVQTSADQVKAQHAEPKTDGHETNVAATETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPK8</accession>
    <name>W3VPK8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPK8"/>
    <dbReference type="HOGENOM" id="CLU_044099_1_0_1"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002028">
        <property type="entry name" value="Related to GTR1-GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="399" mass="44546" checksum="5F70011FC8332898" modified="2014-03-19" version="1">MKRKVLLMGQSGCGKTSMRSLIFSSYRAADTRRLGSTLDVEHSHVRFLGNLVLNLWDCGGQQSYMDSYLDKQRSQVFSTVGVLIYVFDLVGAEGGEEGLEEWERDLRYYKDCISALYQYSPDAQVFCLLHKMDLVDKSRRASVYSSRVKELRRKSREVAQAAANARAAPDGFRVHCFATSIWDESLYRAWSRIVQTQIPALGVLERHLQQLADTCSASEVVVFERTTFLVIAKTASSSAAPLSSSFNKDSIQPTSAGRYVYDEDEEGLEGFRDTQGRVASTPLGSGFITSSTHPAAHSEAMAFGTRAGGLDPERFEKVSELIKNFKLSCQKLPAKSSQCEFQAVELKAPNFSAYIDSLTSNTYIMLLVRDPSIQMASIKLNVQLARDHFERLQAINLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPN5</accession>
    <name>W3VPN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPN5"/>
    <dbReference type="HOGENOM" id="CLU_044094_1_1_1"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="55"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="401" mass="41638" checksum="0F56DE7B1FF96E4F" modified="2014-03-19" version="1">MSVAAAAARAVPAVAPAAAPAPQAAAKPVSSEAQADLDRAALEALELDSDVITSVRLDGLALTKIVKHCRDAHPASASGALLGMDLGGTLEVSNAFALPNPGRGGAERDEEDDRSSRNATKYTTDMVQLLRDVNADANPVGLYQGCFLGAFLNSSVVDGLAAIAGLMERDGASGRGKGVLIVHDLAQSAQGNTAVKAYRLSPSFVEAHKKGKFHTQSLIDHKLTFANILVEIPVSLRNTALLDAFLSSISTPSAPGPSIVQPSTSDLLRNPPTAALAPSYTSLNLALEPVLASSLEATLEIMDEHAAEAGNVGFQARQLAREKAKADAYLTRKKAENAAREAQGLAPLPIEDVNRLFKIPAEPSRLEATLLLGQIDSSAKRLAETAALGVIQLNAAKTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPR1</accession>
    <name>W3VPR1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPR1"/>
    <dbReference type="HOGENOM" id="CLU_050726_0_0_1"/>
    <dbReference type="OrthoDB" id="2555859at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="440" mass="47900" checksum="F0A6E74CD78D50A9" modified="2014-03-19" version="1">MHSAVAWLSKPAPCGSPSSYLCQKVSVQLHIPTSLPATLSPRNRSQTLHPSASILSRTRLHRNIAALIQGITASVYSPRVQCVCVSPLHSQNIDYKHHSTPIHRQTHPGRQPTPTLLHLDHISVAEMKLDHNPFGALRAKSRSLRRKNDRTRIYASSTVACDGGMVSPKLAHGRLSHEDLTAHGASRTSSVDSFGLSHHTHLHHADLATNSAVLLGDDKELHDPNFVRHNWEMMTGEALPDNQLHIGRSASPRLTSRRSTFSSRTNSSRPSSRSGSETGGHHTPAFGLGVSAFSGLSSYSQAGRSSTRSSSSRGLQVEGSILRDEEAMLSDDDSSDDDEFRDDMFPAYRLPTSRRTSPSQLAPPSPRTLLHASLSGSSKPPSPVPSHAASMEQQQAAAAFHRRRHWTVAEGSQAYYGPSAPHVLNANSNKFKERSFSQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPZ4</accession>
    <name>W3VPZ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPZ4"/>
    <dbReference type="HOGENOM" id="CLU_1679271_0_0_1"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="161" mass="17743" checksum="E2DAAD782C8E8B33" modified="2014-03-19" version="1">MFSTAIRLGSRTTYRGSRGSGAGASTRTTAFSSPKSRNAAATSASDGMIFKRAQRGLYDGKTIQSGHNVPKSRQKTARTWLPNVQNKNLWSATLHRWFPARVSTSALRTMDKLGGLDAYLANTRSEKLGEWGRGVRDLLAVKLREQRLNALRKNPPAKIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPZ8</accession>
    <name>W3VPZ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPZ8"/>
    <dbReference type="HOGENOM" id="CLU_086133_1_2_1"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="81"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="176" mass="19220" checksum="4A3961BEA7152A60" modified="2014-03-19" version="1">MNRRTGGTDRHALLAGGAYPTSSSLSAYRSSSPYDSPYPSTSSTPPTYSSSDFVGAPKKEPHGDSILGRATSNYTATRTAEDLEEQNDQRLDGLTARVSMLKEITLNIGTEVRESTKDLGVLGEAFDNTSAFLGGTFKRMNKMAKRQGGWFCNMMLFLLFVTWIFVSTNLPVPTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ10</accession>
    <name>W3VQ10_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ10"/>
    <dbReference type="HOGENOM" id="CLU_081646_0_1_1"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="214" mass="23441" checksum="558449C7C96A812B" modified="2014-03-19" version="1">MDHNYWNVDDFLADSQKLPCTFNVDVPNMGQIQSNGERDVKALSRVELPFWLAELMALNNIVSISKPKAYSNRVKAALDANPTSVQLRHQNIHWYALGARLAQLMDDDDSEMQVLSKAYVGRIAHIFQQSQHLATSSAGSAAAANADANQRGFASAQAIAAMVSDGPTLGMSAGSAMSAEVTEFLQGLDESERMLLRNGQEGARMMREFLANHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ42</accession>
    <name>W3VQ42_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ42"/>
    <dbReference type="HOGENOM" id="CLU_340129_0_0_1"/>
    <dbReference type="OrthoDB" id="2555058at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="835" mass="88714" checksum="4F70D72EAE26E902" modified="2014-03-19" version="1">MLAAAVRKSEPAEQFAELLSPFAFLAAVSSAEKTQARRDVPAWPPDNVQELGRATLGSVSTFATMRWSWWLSHQLALSWPDHATRIDLSGLVHGKRAFNKAPGPLVEMKGKFAATQKGKLAEGLETCRSLFLSESQNSQIRKSKVQLADADGRSLHAKHSATTSSRRCPLRTGLPRASGPTIPICPVHWTCFAAGACAAIEPEEPKVPHGGFVQLIATPAQAPRSILKKSSSEPSSPSSSSPPLSPRPTMSSVSYAEYQPHQWSVAGITRAQSSNSSTSSASSSAPGNRLTVTLLYTPTDTLFAWPFNMSSPGARGVCYETLYSDKETGAVRRPPEGAMSTSLRVLADVIRCWIRIRRDRSSVSRAGGADAAYASASASPTSSIDALVDNDEVVDQIIEDLGMAQLTPFERSIHLLRQVLPDQLSEEPTSPTRAPSEAGSSQVSDDDRDSRHRSDSASSRASTLESTADEVAPAQKASPNCPPKLTIALPKSQQGSPKAEVPQIKLVEATPQEGEYEERDRALERAALARSRKNSPGGMQTVLEAEDEDKAATEVDEEGAVTYIEVVPVDPPSPSIKSQPASPGKPKVTFRDPFKSIQPGQTEPAALQSDEPASPSKSAVVREEETRSVTYLVIFGVAFSDGVLQGAAGVVHCAVSGFLKLTLNPHTIIANAMTDFEKTSSSNSTGTQPLSVGDDRLASDSNFASRQVETGETIDQGGYGLSASGGDQFARENQTGQGFSSTQQQRDSSGGQFQPSVQDSIGNTEYRADAPTDPDTREGPLHDYSTSLGTARMANAGPEDEAPASTATRLASPGLDSTLVLTFATHTISARLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQE5</accession>
    <name>W3VQE5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQE5"/>
    <dbReference type="HOGENOM" id="CLU_368894_0_0_1"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="598"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="645"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="814"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="940" mass="100104" checksum="5D05507618700703" modified="2014-03-19" version="1">MTTFETPASAAVASSPSPRGLQYNHLPLAHNDEPAPPQILFPTVATVLDSPTASSPPRPTISPSYSSSSTSSYASSDVRQDPSTPRSSHTAVSNRGFRLPRFSLWGRRTPESLLIDNNKASPQQSSHADVDLDKLHIQEQTCLTPTWNVDSLLEDRAAHTPELSLPPAPLASSASPMPALTAHAPAEPPSMSTPKSGSVWRLRGGLFAGSTSSASKDSPNRIPSTSANQAQSQDISVPTPPSQFAAWSELLHGPCQPHRSATFSSISSASCSSSSRPNVRKMRSQESIRSVLSARASEPDLEHSYSSLPTPKLVKTKLRSKSKSSKELDFDKVFLAQELYSAVSPSLLGGTSNGRGSESLSPSCAQQEFLAQPGQDSVSRRRSWAPRRSTSPRAAAARLSAEMLAAPQPRRSASQAAPMQSQIGDHQEQDEYYPHGRKVARQLSTSSYITSASSGTTASSANTDHNDVADGQMPKSPTPSAVSAFGDLEVPEEGKTKKAKTPARRFYALQFSLDGRYLAAAGSDQRIRVYEVVSSPAERSEEIELAQLSRQEDVCHRKLSSACSQNGNPSSRAQPKSDGSAATPEFAPVFKSTPVRVFAGHVGDVMDLSWSKNNFLLSCSSDKTAKLWHPNRAECLCTFSTAAIVSSVDFHPRDDRFFVTGGLDGKLRLWNIAARRVQAIHDVPGVITAVAFSSSGEAVCVGTHAGSLLTFACSDTLSLLNTVSVRSLTASKNTQASKITSIQPIKLSDSISGTGTDGAQDGKGPHPASKGEFMTVTSNDSRVRIYSIGARRLISRFKSTSYLNRSSQIRATASSDSQFLVSGSEDASIHVWSLATNATLLASLLPASLLGMKRNKSNKAVKGAPDAGDNSTWRSWSAASSGSIRCAVFAPAATSELLALAQDPLTSSAGPQTFQSRIIVSTDDSAGLKVWRTDPHGRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQE8</accession>
    <name>W3VQE8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQE8"/>
    <dbReference type="HOGENOM" id="CLU_033260_1_0_1"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="585" mass="63461" checksum="E8DD59604B45DDB6" modified="2014-03-19" version="1">MGSQRVPSARPFFPQDRSGVTAAKSDPTRSSAERETLVGIGVRGEAKPATALKRFMRASAPPPPRTFEALGGDVEGKRKISPMQIITDRIGRWAGLGMEMYAQRMAILSASSSGERPLLTPLFATITVTTIKNPVYTSVLCPARSCCRPSRVDRLGRNMPSNASQPQPQPDYIFRPEDPEHADQARADSEVPSNPNIAASGLSRRYRQLSSTMDANETKSLTRMQILTPLSVLLQMGVMILCGSKLIKPNLQQVSRRHPTYLSVQDSFVLFYWAILYVLLIGFSVFLLLSRTPETKKALVHGVGTRLALSNYLMVLWAVFWILDRPLTFILGTATLGVIALLLLFNALVLAVRYPPSAKHPLDWLFIHVPIKMFLVITLQYDLWQQLFMALGYDFGSGGHDALVQGLWPAFGIVAGLGVFSALWIFATADLTWTAAGIYLNIGLLWHKHFSLIGGRDDGEPRPAPLTAAIILSISLQAVALVAGVAWRRIKARQEGRIALPLSPEEEAAVYRADAERNARAAAAAAPSSSQPQPNASARVPGASKPAGSRVSDIAEEEAAAESSGPAPTKVTRKLGGTPTSPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQI7</accession>
    <name>W3VQI7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_11_1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="812"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1449"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="705"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="880"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1206"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1312"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1335"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1357"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1632" mass="177844" checksum="88F3E4F8E8D1599E" modified="2014-03-19" version="1">MDQVQHAMSELHHTSDTLEEIDDPSDLLSRPLEPIPLVPPPSEHNAAPVQSPQRRQLPPGYGTSASTSSSTSNSMGVFSSRPAQQQQGAAHNSLVIDGSGARVPTQFLDSSGGFSRPKPPHGPSGSAGPPAASAPPAASPASIAIPGAYPQPGSSSSMHIQQRHTKPSMAAAKATPIDLTLSSDEEDDVDDRKPTASGSNGKVAAHGNLTLPGATNGHASTGSAPASSSSAGARAVVPIDDDDDDDDEVTLVSHKRPDPEEFEIDHVKSNAIVCAGLINAVVLCIHGIPPALTYNGSIGQEPPEDPNLSRENWPTATHFWIEKGYRPLLLTLSNPANMLPSTRTLPGGWSYTAMPQARRDINVSVILPPRTAHPSLSLQDALAQGHAIEPSFGALAEKYVIALEPLLRQNKVRCETRCRMVPVGRAQNFLHYLEILVFTRRPDLGVVSDQLSAHGIQLEHPPSYHPEDYPTEPQYTNPHNPPAGGVRNDPGIYNGIYRGAGIGTSVQNRELTEKEKKAQVDAIYSSIRSGEELAAVEPSHFISTRLLQHQKQALGFLLNREKDRRWPELLLERDEAAPEAGNTPPKEEKQSPDVKGKKSSPGSSASSKKDRGKKKDDAYDDSISLWKVRKGVNGNVRAWRNLITNRETLTQPRICRGSILADDMGLGKTITTLALIAHTLSEAKAFGSAKVQRDAGAELQAAMQLRDTSNDKSSPGKAVGGVKAEVASGSNGKTDKQKRQASESSFDDDELSYTDTNEDSNTSGSMSMAVHNAPQAAKKASTSKPKGRKSKKDKADSEKLRRQHLECRSRATLIVCPLSVISNWEEQFKEHWTRRKRPSIYIYHGPSRATNAKWIANHDIVLTTYSTLGSEFANQTTWVTDDSKADGKKRGGNKGGNSSDDDNEGHEDDVLVVNGNGIPLQDEAGKNGKKRRRKPAKEAYNPLQRIEWFRVVLDEAHQIKGALTWQSKAACNLTAQRRLCLTGTPIQNTIDDLFALVKFLRLDPFTERAMWNEFCGHRESTGLKSKKDDEPIDSANLGHVQILMKFLALRRQKTTKTADGKPLLALPPKLSKTEYLDFEEAEKARYQALHNLYREDFEEMMAKDTVNNNYATILTEILNLRMTCDHPSLVDASKDARRRAAGADLSEAIKQDGLSRERAAILFLLFRDSEMAYCSECQSPVSPGTDRDRAGDDARDLADALDVAAADGRGSTKRARTDAASSESTSATMSRNGLETPAEGAARPVLTRCQHLYCAPCFRRLIGFPWPEVSASDVGHCPTCNYSLKLAIDAVELHPSDFVDIYDDQGELAADGERFSDDEGVSSKGKAKSGKNEADDFFDWGSGDEEQPSKPKAQRKNGASTADPSTVQRGDLSLEGRKDVSTKIRALITDLLPFSKCNPHSALYDPMAPRLVHVDPTTSDEAEVRAAEEPVVVVQRPPLGVSGEGLLGKLDHTMEAIESYEPIKSVVFSQWTKMLDRIQKSMSITGIRMARLDGSMKRADRSAALEAFKTDPGIEVLLVSLRAGGTGLNLVSACRAYLMDPYWNPAVENQGLDRVHRMGQTRPVITTKYIMRHSIEENMLRLQKRKMMLAEKVGSKRQIGAGAGASGAQARRDERREELKILFGTSSGGVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQL6</accession>
    <name>W3VQL6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQL6"/>
    <dbReference type="HOGENOM" id="CLU_006937_7_0_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="66353" checksum="CF0A67C8BB33DCF6" modified="2014-03-19" version="1">MVESLPPCEQPVLTPEYHDVVIVGAGISGICMACQLKRKFNIHDIKILERSEDPAGTWTNNTYPGCACDVPAPVYSFSFATKGNWSTFYPQQKELKHYFGTVAAEHDLQKNFHFQTTVEEARYDGETGLWHVWSQDWRKDGTDGEKHHFVCKFFVSAVGGLSQPKACDIEGNETFEGPIFHTAKWDHSVSLDGKDVVLIGNGCSATQCVPYLAEHSKSLTQFIRSKHWIAPHPHNPFDNIPGFKWLLQKSVFVRKLQRLLIWLVLESHFILILQNPLGRLFRWNWRRKCEAHLKKNAPKEYWDMLLPKKDELMVGCKRRIIDDDYYPALRKPHVKVDNTKVQRIEPHHVVTADGRRIKADVIVMANGFEPHAAGAPLKIIGANRSLHEHWAKYGEGGMIAYRSALNAGFPNMGQINAANTGTGNQSLIFASECTVNFLLEVAKPVLAAARPPQLAIEHMPGTPADERVQRAKIPTFQVKLKAELDEQHFIAKAMSQLVFTSGCKSWYIDPKSGRVTSMQPDWQVKFMLRSHFPKWEDFTFTGLKNGSYHPSGVPFWKLLGNKLGLGHVPYVDPKETPQINRKAMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQR7</accession>
    <name>W3VQR7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQR7"/>
    <dbReference type="HOGENOM" id="CLU_561540_0_0_1"/>
    <dbReference type="OrthoDB" id="10484434at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="486" mass="52709" checksum="3851534F36CCDD25" modified="2014-03-19" version="1">MDGIMHLIVASPDLRSQPRGLEQLPSSDQLSFCSAVTPLHWQRRPDRRNGPRFDPAGLLRGRRHARRALSLFAGSGPLGPIARRTRDTVASQPVLYRAGAGLPALRSEPTRLTFVEILPTALTRPLAGLTTGALSSRVAPGRASRRNPKQEIFRQSRFSTHESSVPYRLRPSLTEDASESEPTLHTVSDLFASSLRPETDVLQPAGGSGKLRVALGLSLALLHHPTWSTLPDEDHCWLHRRCRSARNASKENVGSALRTLDLLSVLLNVPKRVSGPDDPDRRRAVNPSSRMSPHNGKEFRSTALLCDRPLSVSARALDASVSSRAVSLAVTTVSDPSHPIQGSWAASRPNVGKCPSQAHSTASLSHLRHRPNLSEVVPLVVSNSTPDMQSSCDEQTGVAVCQSRRSNLRYQAAEAQSRAGIRRKHMALERFDSKTAALHRNSGWEAGLVLVCTSPPPEGVAVGPADDDWSTVQHVETLEKAAIGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQZ4</accession>
    <name>W3VQZ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQZ4"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_3_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="42"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="493"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="81146" checksum="C5F3104D321230F4" modified="2014-03-19" version="1">MPTQAFSAPGQVVEEAKAGGHHAHGTHNYPDPLTHIDRTSWDVTIIGAGPAGLMLATSLARFGGFDVLVIDERSEPTTAGRADGIQPRTIEVLKNMEPLGSEFFDRSAPSYERTFWDPRSDGQRGIERTRRVQSFPTDMEIQDNCTLGLQQGLIEGGFLRDMERHGQRVTRPWAYQSFEMTDDPTYPVTVTLEKMKPVLESTNEGGAPISIIKPTGETKTIRTKYLVGCDGGRSRLRKTLEERHEFTFNGDWVDTLWAALDCVVETNFPDVRKIAAIHSKNHGALYIFPRENNEKGEPIIRCYTQVNRLGGEKSKESALDARDKVTAEMVVKAIKEIAHPYDFKFKGVEWFTCYPIGQRLISRYSLPAGKTKTGSAFPAHRVLLAGDACHTHSPKAGQGMNTAIIDSQALAWRINLVEKGLADPDTLLGTYHDERWATGKQLIDFDSEYSALFSGEVPKNTPEVATMSEAEKREHFINIQRRNAAFTTGAGVIYADNVLNHRDPSKLGVDKITDKLEPGRRLQPAWATRWSNSQPVRMIHEIQFTAPGGFRLYVCAGDLAKNMRHLEAFAKHLASPHSFVNRFRPNNRAMLLQNKAYHQLPTSLNTGLAGELSSEANPFFHMLLVVKAQRFDIELEQVQHLGALASMLYCDDIEAGHGAFKVTLDNQFVGALHEKWGLPNGGIVIVRPDGYVGAITPLDQGQSGFEAIEKYFEAFLRPAPHSSLAKTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR13</accession>
    <name>W3VR13_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001592_2_0_1"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="412"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1323"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1440"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1667"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1667"/>
            <end position="1689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1716" mass="191204" checksum="B8DFB8BA6F227818" modified="2014-03-19" version="1">MARSSTSHRGRPSVHEPNASIWPIQLLDRGKNRFKAPSSSATTAQKRFAYVPVPLLDFEDLSFFVNFDWIAAKLGLDPSGGEPDHLRAGAKRRHASPEHDTARAKRAVKDEVTEQTSTDLADLVDTHCLFRVKARESRDIDSVLAIKEQLDRPSTHERLHVADVAFDLEEFSPGRPMGSVISRSIRLRDVDTGTLIATLPAVADDASKDANFDPHKLTNSSWITSLSHLLSKDAVTSRASLDIVSHPSDYPSERVTAGSLFLKLSIRVQAKVSIDATGRLAADLMLDMARLVRLALPPNQNAQVVEEGQEMERDVEVDAGFVYRNLRPASLNPPESVQHPDLVPTLLPFQRRSTAFVLGREGVVFDAQGNLVKSDHIYGHSGPSDLGLWWCRVDSNLFYNWIEARFVRDPTLTRLSNCRGAMLAEEMGLGKTVEAVALMLLSPDPDATSRAGWYDDRNEIDVVPTKTTLIVAPETLRTQWIEEIEQHAPGLSVYSYAGRTKAENDVPEGLTWEQWAQRFDVMIISYATLSRELSTAKSERTRSRRFERKYERPRSPLVKLHFHRVLMDEVQMIGSSNAAETVSMISRGSSVAVSGTPVKKLDDLKSCFRFLKVPGYLATPAEWQSILHPLLGPALVQVLQTIGTRHTKAQVAGEMSLPLQTRSVIPIDFTSIEAAFYADVWSDALNDTGYTTDGNPHSQDHQMDVSKMRQHLLLLRQACTHPQVALQFRGGVVGSKNLRSIDEVLELMIDSTSTELHSTRTHWFDRRIHRNILGLYRRDEDQRVLAASQFSDIEAEIHRNVTVLEREIRDASTSGPLYRFTADEIELEQKAEARRKRMDPTGADQKNDEDADPALAALMEDPEAYQALLDKRKSRAAHVTQLKALLRFLLMKLHRLLQFQGNLYFQRGEFLDEQQSATVSALPTTPPQESYTANAGQVKVEDNVDMVRDLTTPPLQSAEGDVRITETKIENVLKPTMSRERQALKDKEDAAYAKAEKVRQRLLVEAGEEVQAAIARLNRDQVELDAAAVRASTDLFEEGGGIRSSEAYGMLADNVQLLDKHAQVLFRWRGSIIDRLVRAVNRDVSLEREDDDQYQENLDTQAEAEVLLEMYRPLLSEREKILKGGVAVGATDRPRLFKELEEAVRIARQNDLRGIEPETEADEELIRVQKQQLTHFKTLDQERKSVSLYNGKQSVVSVIEQLKALRDNSLRNEETVLATRAYLEARRIVNEQVKHLDKLRNEEKLLLTALFNARSRYFKEIQVLSDTVRDPIFSDLERNIHSTQKEESDAVSKVDELERRLRYLLHLQKVQSADDLDDEAKICNICTDPIETGILTNKCGHVCCENCWKEWQSQGHRTCVLCQTRVLPTEVHRIIYSRPQASAKSGQVASTTSRSGTLANAATGFGADPLAVRYNELDDNLRGVLNRLATQGRFGSKIDHLTKHVQHIVNQTGEKSLIFSSFGRGLDVVAQALTANGIRHVRLTGAGKSGSESAKLFRSDPNIHVMLLHSEVQSSGLNLLAASHIHILEPLLNTSLELQAIGRVHRIGQTKETHVWCYYVKDTVEERILALSAYKGQSIYLAGRNTSATDGSMTLATSSSNKSAAAEQARQDAKKWSAFGKGAKSGKAGAIRGDITSNTAELLACFFARFLPALGSIPANQSSAISANSASASGSNGHTVANGEVGSGSEEVEDERTRLRRARLAALEQRQAGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRC3</accession>
    <name>W3VRC3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRC3"/>
    <dbReference type="HOGENOM" id="CLU_1161788_0_0_1"/>
    <dbReference type="OrthoDB" id="2525787at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833510" evidence="3">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="267" mass="28649" checksum="2319975A68858323" modified="2014-03-19" version="1">MPRPHPRTRPSRMALMMSLFFLNALATETTSSTPPRSLARRDSWRPDTELPGAKFVLGDGKTEGVKAKGYQGEWPLWSGFRNGQASDKPVASSSGSQPAAAAGNATDYVCVAAGDCNPCPDNVVHLPFCRPYNNRRRVACSPVADRADASAVRTAMDTANAARNATDSTAAALLGWEACGKSAKQEAKDYFEMIAVVAVLAVVSVWAFVQRQKVLFQRQNQQLLYRVSGQRRSSGMPNATAATPRAPAPGRKRAARLAPPLASSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRF8</accession>
    <name>W3VRF8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01307</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1158"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1309"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1382"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1409"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1494"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1521"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="452"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="837"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1310"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1587"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="803"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1711"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1871"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1711"/>
            <end position="1720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1893" mass="207792" checksum="6389D44CBC75CE45" modified="2014-03-19" version="1">MVLPTSCAGRRVWDGIDWDVCFHQQVLNTFIPWSLVLLSILALAVHRLRRRRALKVSAQHVATLDPSASSFSAVLHAQASSLPSNRASAPPQNPWMQLPRRLLSILLPWNSSRILRSNSISSAHSQPRPISKSDPAAAASQAALEVFHTENAVILNEVHLTPPTARDPAVVDHLRHLELLRRIIDVFGAILLAALHAGDWATGWHSRSYQISWAAMWFYLACISAYSLASKHSFFSHKAALMAVYVAVSLFNLRTALLNYNANPRLHSRSALILTAIELGVGILVLIPTLFFPLQSVLPRDLRAIYTTMSPETQHGVPGTAFPSPRLATLDGLAPPPQPARADDAANPDLIPAPEETASLISRATFGFVTPAIVKHYKVQFSLGAIPDLPVADKAAAVVACFRAYTSARSDTAAASDSTPRESGLHAGLAPSTRPLWRRLFGHFKWFLALQFFWATLEAGLNLVPPFFLQKILGFIAARGELRRNGNMEDAEPLHLGILYAFGMLVGQIFSSISSSRALFIGRRICIRLRAILITEIVTKTLRRKDIGSTGDKDDKDDAQDESADQGDADSTEAAKKKAADDKGASTGRATDGQVVNLISVDVFKVSEICAYLHFLAPRAPLVIGLCLIYLIALLGWSAVIGFMVLLASLPIQTLVSRWFVKLQKRLLETTDKRLNLATEVLGCIKTVKFFAWERSFNARMDEARQRELHVLGLRYLAWLCNTFTYMGTPMLVTCATFGAHTKLFHQPLTAEKAFTALALFNTLRNPLDALPDMIVQILNSLVSVRRIDTYLREEETQKYQQLLRDEDSSDWGDADANGRNDSPTPGSSAHGAGQRIGFEDASFTYADDDSDVEEGAFCLRDINLRFPVGKLSIVAGPVGSGKTTLLMSLLGETRQLAGRTFMPCPVARATAPIDPTTGLSESVAYCSQSPWLLGTTLKENILFGSPYNERRYRAVIKACALEPDLKILEYGDETEVGEKGTSLSGGQKARIALARAFYSSAKHVLIDDALSAVDSHTAKHLYRHALKGALAKDRTIILVTHAISLCLPGAAFAVAMDDGSVVVAGTPDVVNATGVFSEEGEALQSRLKELSANEGDHEEMTIEELAAGGSDEAERQEMAKKLEKKKAHANEETYSSGAVGTKNYGLYLGSVATKARYAVLLWGSLLIFFLTVRLLDISSGAWLMRWAGSHDYREEKTGFSVASSATPSEQKPLLTYNQVQTFMTTPLIDTIWSSRPDWLNGARFNGFLGQMPDIFTTKEATFVPAANFSGYTASEAWTSTAGQHVFSMQKRSSGRGGDGADGRDLDTYYLSVYLAISLGFMIMAVLRDGYEFFISLRASRRIYRRLTDAILNARPQFFDRTPVGRIMNRLSKDVETVDQEMAVCMLFLLECTLTATAILILICWATPIFLVVALIVVCVYSVIGALYLVSSRDLKRIESVERSPIYTVVGEVLNGCVIIRAYGDAGRFTRHCLRLVDKANRAFFFLWYENRWLSVRVDIAGASVAFLSAIFLLLRPEIEASLAGFVLAYAITFVESVLWIVRMYTQTEINMNSVERISEYLELEPERQTGTEPPAYWPSSEGKIVIKNLAVRYTPEFPRVLDGIDLEFQPREKVGIVGRTGSGKSTLALCFFRFLEAEQGSIEIDGIDIASIPIRTLRERLTVIPQDAQLFSGTVRSNLDPFGVYEDGELWTALERCRLASFATPAASRAVSRAPSRPGSPGPEGEEEGADAEMYGRTNIITSLDAMVEQGGRNFSAGQKQLLALARGLLKLRDSRILVLDESTANLDSASDAQIQKTIRQEMAPQATIITIAHRIKTIADYDKIVVLGKGKVVECGSPLSLMTDESSVFHSMCEQSGEMGELLRIAREAEAQRSPSASTSTTAANSDRGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRM4</accession>
    <name>W3VRM4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRM4"/>
    <dbReference type="HOGENOM" id="CLU_012596_1_0_1"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF160">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="63142" checksum="2C064ED1FE4FA0A0" modified="2014-03-19" version="1">MARTDTAARHLDTEQHQRLLRRKLISLAGSVCVSLSAGSNYAFSSFAPQLQESLHLSSTQINLIGIAGNAGVYLSSPLWGRFIDKRGPQTALVVAAVLVPLGYAGLSASYTGEWRMHSTPLLFMLNLLTGLGNSGGFTAAMNAQAKSWGGSRRGTATALVLSGFGLSAFFYSTLSHLLFPGNTGDYLLLLAFGSMASMLIGLGLITIIPPLEAPAPAHAERSEGGSGYLRRRTSSDIGARATVWHRPEALSAEATDDEDEPRAPHVGGSRDAMTPADEVDPEAQGLLSGRDESKRTGREVDPAHVDISGRKLFRQPDFYLIFLVMTLVSGAGLLLINNVGTITKTLWDYNHRTDAVLVAADNADLRRRAPVSTEAFETAKKSAKSSVQQMQARQVSLISLCNFGGRIFIGLLSDWLVNRTASAANRVWLLVVVTTLALGSQLLAAFPGAVDTVDRLFAVSALTGLAYGTLFGVCPTLVFEWFGMKHFSQNYGFVSLSPVVAGNVFNLLFGHIYDSHVPTDASVLSAVSDVLASVRGKNDHPATRHLCMDGEECYRQVFVVTSAGCVVAVLLSLVLIARRATNVPSFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRU1</accession>
    <name>W3VRU1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRU1"/>
    <dbReference type="HOGENOM" id="CLU_329603_0_0_1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="685"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="746"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="776"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="822"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="847" mass="89993" checksum="610143A490AD4A3C" modified="2014-03-19" version="1">MSSPLTWGKGASWGSASAASAAAVAEAACPLLLPTASLPGLPEGAHKHPLQQPNSPSHTKGLESLALQLFLHLRLRRYLPRSSQGGIVSIECGSAKTPPCSSASPRTAMAASHLPLRRPSSPPGHMAEVKACAGVICCDADHSALPCVDSCHDCTLSASASPCSDAHHISSSCTEPTCGAASSSTNPGLCTSAIACCDDTACEDLATSPCSDGACSAPECSSATIAVPTIAACCEDEACEPVSSPRLVAKPKASTRDRLVPPELEASAHVKAHARHSDKECQECRGSLSVSDSAEGGRMYGSFQELLDCCCCSMPPTVDQCCVGKTPYPCSTSPPHPHEHLVHDLAPASFTSDTPSTAITHAAPSTSPAHNLCSRSSTVSSAVTPQPLTESPASAFPWPADYVAATNNDKHKPPTTFAGQAATLDDILTELQSWNDCLFEQPHMHSSGGGCLPPAMTLCSSNVCPTAAPHSHRAPHHSRGGVEGENGHHDPRPQMCQWAGCNERFWTVEELVAHVNHSHLAPKNTQAAESPNTVMQHAQQIGTIDAGKHAGASVECLWDDCHQVPMPMAGKLQDALLPATAGGDVWDNGVGDKFSLAILQHLLHDHLGQHAHHPGHADAVLPEPPKEESEEVKVKKRKASTSSGSSCDHGPLVCRWEGCSLEFDTHALLTEHLEAAHVGSGKASYECRWTGCPRHGHKFTQKQKVLRHLQTHTGDRPFKCTVCGKRFSEQNTLAQHVRTHTLERPYVCDHPGCGKAFSVAGSLTIHKRTHTGSKPFVCSYPGCGKAFAESSNLTKHMRTHTGVKPFRCEECGKCFSRPDQASRHRKTHERKRHKQDQPAHANGELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRV9</accession>
    <name>W3VRV9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_234601_0_0_1"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23179">
        <property type="entry name" value="T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="1457"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1961"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1961"/>
            <end position="1976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2024" mass="213685" checksum="9AFB447F515C82DD" modified="2014-03-19" version="1">MRTHVHAERPTATPNPALGFLPSRPSATTYTQSPSSISSCIPSYSLRRPCHARAEPPPSLSASMDVFPAASSTMAQGAPPGLSRQGSIARTNAIAMLKRAASNREMKAKADTSAPPPASSSPNIPTSDAACLDPTSALTHIHPSHAFNTTPQATDTTAPPAIAAQLLPESPPLLANPASSPPHTANTLLAAPSPNPASESASSRSRSPMFHDRPAQRPFNRSPLPSLEQLRARILLERESAGLQPSASTSAASQAARAYALEKLLGNSGTDVFYDHTPDGTLIGRAAATPSPTAMARRDADYADMASDDESAHESGLRRQSIRQSIKNRPMLRRSRTINGLTAMAEAQNKAEFVQGVFLAVPGPASNRISRIHQRRVERQSMLQRASTSTGPSEPAIPEHSSDANQDATTQPTAAPTLERQPSQRQIARTEMMRKLSTRGRGTATPTSEPSAAAAPPAPTVQHPRLPQLITDSPAVDETISPVGVVIRPPSSPVPPHMSHLDLLGAASSPVVFRQNLSPASAAHADIHTGAVSSLAADLDLSASPSLKPSSSAASLASNYAHSTATNATAHHNYERNRESAMALLENEDNFGFEASPSFPSIGTDLARAQTPIDHSTAAEHTSNRDRNGVHRIPDANASDNEGLSLDFGDARTKRRAGLVGLGLDSVAHASASPQVQQPGQSSTAQDQSADLPSRSHPGAIASDRNTKARQSLAKLSVKPSPQDLLSSPASYTDDEPLEDEAFYKLYSPAAGLYDDDDDEDEDRHHPPATQATQATSDHQPSQSDRTSQTSAPAPVQGLGLIASGAAAPADAELPNTPPQRLFYRGNAAVPCDPSPGTETDFGDVRRTPWMGSSPGGFNLPLRLSKSLISTAQSDSPAPDPSPVMRGPFRRARGDWPMSVASSGTHPASRESLESRSEPESRFRSSEEGGIVGGAPAIGSPLIELPEDEAMGKEGGVDEQPPQPAAPEFELLSPSSSSKPSERVQAMLGSSFVAEYGAELESESRSRSSIGADEDNQLQVPGRHRAGSTNTHSNVSINDMSDVDGEVDEAYLQRVDRMADKLGKIARAKHLHSKDSVSRAVVANITNAERGRPMGGSRFTEQLPSTALGSQRTSADLSALAGNEKLHPFPGLTQASPLLSQEGFSPKNGSPPSASRANSQSKGTRPAAGDSPTLATGQKEDAEGSGRQIGLFSSLRRKASSLRRTPSSAKGAGGFLARRGKKDESPKMPSEASFISAPILTTATPGPPPMATQPPVAVADKDVEPSAGQADAGRDVTFEHRLFGPDQSGDSAGAELQRNASISSVVSARIRGDLQDGTADADALVVPAAHGGGGSLAPNTAAVIHRYSRMLSGAAPPQTIPGASQQDLQDPPRKLLATDAVFQVISATTIKDRYLFLFSDLLVIAKPVAAPGAEAGQTLGKMKEAAVLPSLSWRFAVKNILELHRLRVSVTTNTRTASAKTRAQNPVLWGFVSHFSREPDSAVRALVAKTGLEPTPASIAQLLYQTPELDRQDLTAYLGHAARREILKAYVSQHRPVGVSIESALRSLLLDLRFPHELDAFEALLVHFAQSWTQANAAMIKPNFTAQLASDLVFAIMALNDALHTGTQAGAASVTSPNFPRPVTVVTPGLFSAPCPELSKADFVSVFRQHDPEHVLSDRTLSRIYLSIKSEPLVQALDRYEPRFTIRVKGGKLPTRLTYAQPAEPVTLVIPAPDPDLAIRLYAPDTTFEPPVLTFGASREASFTMWTKSLGAKQVVFVRAGRNARFYGGTEVDVTHAGAGGADAGVREDSPLPRSFNVAVERAFMKHSFTLTSVGEAGGTKRFMLSFEDGERVARWTHVIREQVAAAEAARTRSGAVATARAMQVASLEVLRETLIGVEPRAGLSRAATVTGVAKAGMGDLGRLAPVAGLDRTTSTSRHYYASSGVGRHERELLLPAPQKHTKGSASLSLTPMAVGVGMTRSNSARSASANSPAGATQPLPPAIQVAEPETRAPQLHGTAIVRIARLNSLLPSVVQHHLNGPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRZ8</accession>
    <name>W3VRZ8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRZ8"/>
    <dbReference type="HOGENOM" id="CLU_027355_0_0_1"/>
    <dbReference type="OrthoDB" id="3363836at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="590" mass="64276" checksum="0328C7DA1E43063D" modified="2014-03-19" version="1">MHHHHHHQQQLKQRKVQPNNTKRIVKRQSSSTIDNSANCLSGGLYVAPASGAQVQVTNVTEIKWDQSCLDASVSKIDIYVYSPSMPDQFLPIHVMTGIPKSAQLYNTKLDPRWWGRDLAHNSSVPVSFNIVPAGNEPWDSSNPMGPTFVANYNVPDQGGESKAATYFGKLTNSVKTAFLENGHLTPAGKTAAIVCPLVVLGVALGLLVRRLHIKRHNKTVDWADHMDKRMSRISVDWTTGGDGSAGPVPGTRPASYLSRPSRDMDAAGNFAGRGAGARIPRQMDDITPAFATDDEMREARPRGMSIYDEGNRTSRISFADNTRGDRISRISYANSSDAHGRSSSHLPRVGQQGNMRRSQLVDSYYDPDAPAVPQLDARYRASEDVRRSRFSDGLIYAEADELRNPQHEDDDEVLMSPTQNEGPRPLGANDVDRMRQSLDANARNSMLSYPALSMMQSGREGSDGHDMFDGPNAARRVSGGSADSYIDHMHYQHSGNGAAVAHLERTGAGVSAQTGMAPPSNFASPDEAMKHYASLRAGSSAVETSAQSSRSLYTPDAANHRGHSSVAGSSLNEEEVVGYNEMIDHGNQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS78</accession>
    <name>W3VS78_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244240_0_0_1"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="568"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="903"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1312"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1491"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1602" mass="169394" checksum="939D2695425FE244" modified="2014-03-19" version="1">MAAASSRPQSGFHAAPTPSPVGGRSFIDHAKLRILLAPVGDIDEAEFAKWCDAVRSFETIRLADLPSSCAARQQAARHAASGSSASASTSTSPILQTGEIHLSFVTSYDPDHAFLAPFNMHRQVLGALGLATYSNNALNRHELEASPSALRELHPGALVHRVFGFDSGAKRPETVDLSSIKDVVAAKINSSQRTGSPLNPAAADAARPGSAAGDDSAGGVSTPQLPSSPDASGFSAHRDGGLIIFPAVRRDGKDVRFYLKTLLAELVANILDALDHIVTGLEGTPLETPRETLDGIASRNASTPTSSANNTSWLGKTGTSATGASLAAGMGAAASRASSLFGAFSSSSSSTAGSTTGDVGTGTSTPTSSRPSSAIGGGSHPFDLASPGSKTASPTSESTRSKILAANANKKSAKRVTSAAATGPTGSGRYAKVRADLHLLSGNLWAALEAYSSALVALGKERALAGGQDAVWFASALEGFSVARVLVSRMGGAVLEKAPCFDLPWSAANAKDKDKDKEKDKDGIPRPYAKQSWGEVAEAYTIALVIYAKCLAPPSVLLEPVRSVTNDSPRDYTHPLIHASACTQYARFLLAVWASGGWNGECFDQLVYGGVPPALAEEKPSNAMYLALTAISGIARHDIAAAASSALTHSIIALKPTDQITLLSTLTAIFGCIGFSRREAHLLRQLQSTIVALLVKAKRVNAQPPATASLPLQQHAHFDKDASELLGNMVAQTTFDSLGRGPEAVLVLAVQVCETYGIHVELDPLRGVPPFHILSRASEGLRSAYASPALAGSESWKADGDPRPSVQAALLTPEELAQEAPYGWKEQQIALLKEAIATAELLTDYVGMAFFGAILLRDFNALLDADEQRDLIVGMQRAVQAARWAGAQDLSLKYWGPVEPLCSLELLPLAADRLPHEREAKHVWSDAAPKAEEGVAGLNNPMFMNLPAARTSAKARATAVQHEPIHVMATLQNDFATELHIDSVKLVADGAGFVAEESERISIPPMSFHTVRLAGTAKEVGTVTVRGVTLTLAGGCTEEHTFLLPVYDEDNVRERRKRAAEADDRKTRLKECGLDARSAVVKQKAVAAAGDTNRKASANKWIEISAVGAQPLVAAYCGALSPLGGLDMFEGESRLIQLELENVHASLAVNYVRVAFSDDASEAAQQALADGELLPADVHEVEWDLVHQPALSRDPSDTRGDAVHIEAGASTTLPVRVTAKAGCTYAVISLEYAHLDRSKGATTKVHVRMLEVAFRLSVHPVVVCRDLTIVPLRSGEAARLTRECLASADAVPPQLRTFGVDTETQVSSTPVPLEGGEAETDEEYCLVSIEVSNVHREDVLVRFALNTGGLVPLQLYRVLRAGTTTRLVLPHPRIELDATGQPATGQGASGGLPAIPSVWAGAGTRQFIVSKLQLSAAEEAEMRATFWYRDALLKRLGGVWKTMRTEVALAERGGKVPLRGMVTGGLEMDAADREALQKSVVGITLAFEPNPVRAEAFVRVRATVTNRVARKIQPIIRLVPTSLNGAADTDAQLLASMVLADGTWTAPRGDPIPPGEQVDVEWHVAFLSPGTFAFVVSVQEAEPQQDPRLALVSAVHTLTVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSM7</accession>
    <name>W3VSM7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gpi anchored protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSM7"/>
    <dbReference type="HOGENOM" id="CLU_038125_1_0_1"/>
    <dbReference type="OrthoDB" id="526316at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834839" evidence="3">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="98"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="416" mass="46043" checksum="C85354139E1149C2" modified="2014-03-19" version="1">MHLRVIPFLAAGVAVAFAAPHHRRHDGFQVDTFKHPGALHSSSDIQRIRNYVEEKKQPWLRAYEHLESMPLVQTSWQSSAHEILVRAAAGTSNLTNNYPSAYRDAHSAYGLALRWLIGGNTSYADAAVRTLDAWGSTLKKIDGNEDKFLAAGLYGYQFANAAELLRDYPGWDRTNKTAFSSMLSSVFAPMNQDFLINHNGKPNFYYANWDLCNIASMMAIGIFTDNATMYNWAVDTFLHGLPDSSIVVNGALPYFSIANFTEVDTGKTLMEIQESGRDQGHATLCIALAGIIGQQGQNQDVDLYGAFGNQILNGAEYVSKYNVGQDVPFQPYTSWEGNLTVVSPKARYEVRPGFEAVFAHYNNVRHFDASWTKAFRDYVNSNNTLDIEGGGGDFGPNSGGFDAFGHGTLLYRISPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSU2</accession>
    <name>W3VSU2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSU2"/>
    <dbReference type="HOGENOM" id="CLU_053731_0_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="227"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="364" mass="40846" checksum="8E4D6D150F4B54E5" modified="2014-03-19" version="1">MAAIASGSSVTLEHMDAADRAWAIQENRFRAKARLRLQARARKPRSRPGHPTAASTAASSAPTQAPNGQPPNGSAVPSIGPNANLRSVPSTSRNAQLEPGQLKVVGSKGNAARTRKVDEGEIPLQRDKSLGDYIEFDLSKLHNSKGGFLIDDDDPATSAKTAEELRKAKERERQRLRDYAEPGISLDIQSRPVCESCGSPEIIDHPFKKVFGILVCRKCERDKPEAYSLLTKTEVKQDYLLTDAELKDEELMPHLLKANPHKATYSNMMLFCRKQVEQFAFGPGKWGSEAGLDQEFERREEEKAKKRGKKFQQGLADLRKRTRDNVWQKRKDQEHVHEWEEVQVRGKATQRCTQCGYAVEVEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT39</accession>
    <name>W3VT39_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT39"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="78"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="653"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="690" mass="75107" checksum="652E969BBE3C574D" modified="2014-03-19" version="1">MSANPSRASTRPSGEVERLSYDNGSATPRDSAHRRQRSNTSSSLRSNGTVRAPSVNMDHDTSPLAKIGIKGDGLMLFVTCFASLGVFLFGYDQGVMSGIITGPYFKAYFSHPSAYEIGTLVASLELGALVTSLACGRLADIFGRKNTLFWGAVIFSAGGAIQTFTSGYDTMLIGRVVSGLGVGVLSMIVPTYQSEISPAENRGKLACIEFTGNIIGYASSVWVDYFASFIDSDLSWRLPLSLQVIIGTTLAFGSVLLPESPRWLLDKDMDEEGMRVLADLHGAGDPNEPRAKLEFREIKENVLYLRKQGDNSYRRMLTQYRFRTLIGMSSQMFAQLVGINSVCYYLPMILESAGWIGRDALLMTGVNGIIYTLATVPTWFLVDLWGRRAILLSGAIGCAAALCSCGYFLYLDRDYTPQAVVASIIVYNAVFGYSWGPIPWLFPPEIMPLAFRAKGASLATATNWSFNWLVGELTPILMERIGWRLYILLAGFALLAFVTVYFCYPETSGVPLEEIGALFGDEINVPQDEDDENSDEDDEEESSGARRRSADGSDGDGYSRPIRRSISSHPRLQSEEERAARAAAARVAAEERRAAQSFFGLGAGSGPLRWLGRLLGGGKSEAPPDRRLNDAGSAGIETEALLMNELRLARRSPVQPARAGSGVEDDQDVFALGSEDEDDIGWEQGGMKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT59</accession>
    <name>W3VT59_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT59"/>
    <dbReference type="HOGENOM" id="CLU_114221_0_0_1"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="185" mass="20134" checksum="C335DC67B3D9156D" modified="2014-03-19" version="1">MASMFRSSLRTALRPASTSASSSSALASSSKLRLPSLRFNSTSTTPLETEAAPTEVQDEATAVRYSYFVPRVGKTLDSLPVYTDVRNGGTRTMTEVRKIQGSVQDLKLDLEVFLADTYAPTYPDSPLSVNKKPLRPKPGRKLVASVANPTYIQPVAQGKVTNAGKLKIRGNRVHEVKAFLESRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT71</accession>
    <name>W3VT71_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00681</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT71"/>
    <dbReference type="HOGENOM" id="CLU_060944_3_0_1"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="108" mass="11835" checksum="25CD07892A85C055" modified="2014-03-19" version="1">MGFKEGDAKKGAGLFKTRCAQCHTLGAGEPNKVGPNLHGLFGRTSGTVDGYSYTEANKNRAVEWGNDTLFEYLENPKKYIPGTKMAFAGLKKEKDRNDLVTYLAEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT73</accession>
    <name>W3VT73_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT73"/>
    <dbReference type="HOGENOM" id="CLU_006601_2_0_1"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="250"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="666" mass="72461" checksum="5CFE74C013BBF189" modified="2014-03-19" version="1">MQPERTFWRGGASRPLTRPSDCASCLNAPISSSPAKNIETAGRLLHTTMAATLQSVLPAPRYSAASVSHEEDAEVDDHAAYDRAEAGPSTSASSSSSALVSASAFSAPPYGQRSSWRPRTQADFGGGGAYPECHIAQYPLDMGRGRATGPGNKLAMRVDAEGNKRYDAIVRQTLRPGQTVQTQFKDLVPLSHRSDVRDSDRSSGLERPSQEEVMSNTERTRLALEALAKGKTKSLVPKSANAAGGQQAAQFIRYTPGQQGAGNASQRIIKMTEAARDPLEPPRHRIKKVAQGPPSPPPPVLRSPPRKVTAQEQKDWMIPPAISNWKNNRGYTIPLDKRLAADGRGINDVVINDNFAQFAEALNLADRHAREEVRQRSIMQQKLAAKEKAAKEEHLRNLAQRARDERAGVSSATPSISGRADDDKASRLDDSDVGARQSGGAGDGMSAMLAGYGSDSESGSGSGSASEDEDDDGARERDRIREERRRERERELRMSNMGTEQRAKQLLREQNRDISEKVALGLAKPTASKDSMTDTRLFNQESLTGYGDEDSYNLYDKPLFSGSSAAAAIYRRPAGRGGADDIYGADDGAFEEEMKNNDRFGLGQSKFEGAQDERQQGAPRSGPVQFEKDESDPFAINQFLDDAKRGIKRQGLDSEAARKKTRDESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTJ8</accession>
    <name>W3VTJ8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTJ8"/>
    <dbReference type="HOGENOM" id="CLU_2484266_0_0_1"/>
    <dbReference type="OrthoDB" id="10565485at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="87" mass="9556" checksum="49CD9AD9B20CDDAB" modified="2014-03-19" version="1">MLARCASLPMAKRDGDPTLRHRRTALRGDGRARRILQLHARLRDDVGRAGSAHRVVASELASAIRLRATLQHQGLTRCGVLAQPKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTN9</accession>
    <name>W3VTN9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTN9"/>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="541" mass="59258" checksum="8540BBD1D2C75AF3" modified="2014-03-19" version="1">MAEPQIAYAQDEYGRPFIVVREQGKKTRANGIQAIKNHIAAAKTVANILKTSLGPRGLDKILISPDGDIQVTNDGATIMNNMELDHQVAKLLVELSKSQDDEIGDGTTGVVVLAGALLEQSEALLDRGIHPIRIADGFERACNLAVQELEKVADTVDFDRDNITELMKVAKTCLGSKIVSKASDQFAKIAVDSVLSVADLQRRDVDFELIKVDGKVGGGLEDTQLVQGVVIDKDMSHPQMPRVVKDAKIAILTCPFEPPRPKTKHKLDITSVEEYRKLQDYERNKFEEMIKRVKDCGANLVVCQWGFDDEANHLLLQHELPAVRWVGGPELELIAIATNGRIVPRFEDLSPEKLGRAGVVREVGFGTTRDRMLIIEECANTRAVTVFVRGSNKMIIDEAKRALHDAICVVRNLVVDNRVVYGGGAAEICASVAISKAADEIASLEQYAMRAFASALDAIPLALAENSGYSPIETLAEVKSRQVTEGNPKLGIDCMGAGDNDMKNCRVFDPLVSKRQQLLLATQLVRAVLKIDDVIEQHNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU49</accession>
    <name>W3VU49_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU49"/>
    <dbReference type="HOGENOM" id="CLU_1151659_0_0_1"/>
    <dbReference type="OrthoDB" id="10367217at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833410" evidence="2">
        <location>
            <begin position="26"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="227" mass="25366" checksum="3EB56920D40A5BDE" modified="2014-03-19" version="1">MQLQEPSRLLGLIFCWLYLLTGAIGTSEESDGVDLSLRLGPRPAAIRFPHGNVVSGPSGSSGQLTEASSSGQAQRERDQPGPSTSSRPLMQGSGEASAMRGVGTHMDRWPVESSRQLIQRLDAHENWEAYTRKYLGRPLEPFVHDGSFIPQKAMEFQTRIDLLVRAKREKAVLRQPFRNWRTMSRSIAVDDSTSVRVAPKIVYRAHEDLALLRSKEDILRRLALMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUA2</accession>
    <name>W3VUA2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUA2"/>
    <dbReference type="HOGENOM" id="CLU_308376_0_0_1"/>
    <dbReference type="OrthoDB" id="2556767at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="957" mass="100927" checksum="ABAAB725BFFFEA2A" modified="2014-03-19" version="1">MDEAPDSSVSTRRKLPDHANNLFVITRRCLFARRPDKSQPLPVLVRRAHPSIRGSVDTAPLPAHRFNRFGSAEMKAACAAHTLASSASSAGRGSPLDHKAFVGRCGQPSNCVYKYCPSNSAPLVFIPNISSPNMQELAAHPHPESSADSPVWRLGTGKLDEWLKAHLPSHLSASSAPILVTRADPALRVAESLTDVQTAADDTFINAKQLMNEAIANVDQIQKDDAIPVRINSRSTKSSKKQCRDQVQNLFHDQIMLMATDHPLWSQGRWTLILNPQHLDATWTRLVKSFEAGELQAQPLVIALRARHLPPSESLGEHSHGGQKRKKAASSRSSNSRATSSSSSSRTDNERSVAIDVFFRAVWSSEVARNVLQSVAEACGRMPIFCRASLYSLLGIRSGHPLGNRSTLYNSKAFASPAEFNLWTSKHERSEGDASTAGMSAAAVPSAAGDNASVAEAPAHVPSEPSAHLPSEASIAETAATDREIHAEAAAEERPPKKVRIDSQPTQVPKAVEEPTATAVEQAQHATQETASTQDELMLPVRPATAPVTHKAVEPSADQNEKHDLDTARKKEPEPAAAHKHKPDPIVTEQELGAAEQKGPHSGIAADGKPSDDAAKEVPELGVDQHAKQEPSAEAVRPGTVSDQEIGSTTQDEPKTQEESQTQDESMTQIVPIIARGQDSAGAEAQPENPLQRDSVTVARSSAAVEAAAAAAESKPAESPKEPPSPQQKTEAKASTAEQHPADSAAASVKPEKDVQASEAVQPSAGSATASTQQQKDVEPSKAEQHPAESAVALTEQLSPASVTKASDGSMMVVDVESRREIKETLTATLELPMVASVDQKAVPAAKHEDASDTSTIEVEKGSDAAAAAAASVGEEATAPKQVSEGEANPDTAAAQKATATDAAKSDDAPAKADESKVAGAEMALEDLIVEAAVAVELAPPAAEAGADQRDDGPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUM4</accession>
    <name>W3VUM4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4 beta-hairpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUM4"/>
    <dbReference type="HOGENOM" id="CLU_003639_2_1_1"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="800"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="852"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="923"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1125"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1129"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1168"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1181"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1193" mass="131782" checksum="B58B44419CE65BBD" modified="2014-03-19" version="1">MSSARRPARRPPRKLPRLAHDLDRPDADPEEVLDIHTISDDSSENMPSRVRNGRASPSKPSPATKSRSRGTRPSAAHDVIEILSNASTDNAHDDVDMSDFEDVDVANASPATGASREASEDLEMEDVDLDPDNSTKDLHDMYADAYREVQAKYGDGAIGEDGQEGSDQEQTGDDSTTDPKAIPIFKDGKGQHRGVEISVGSRTPKQSGSTKPKSTSLLTPRDRQNRITAHKLLVLSMLAHARVRNKWCNDNDLRDTLADSVPDYLITKLRSIHPKKVPEQRERIRMFESFLSELVRWWTARFRLDPTMVAASALRQPDQDIATGIMPSSGRRIDGWVVETAAEREQRHRRERREQQRYRDAKEQQANTKTKGKGKAKAASTASALLPPTKAMEITIFAPGSAIRPIYLRLLSAPETISSPAELKQRALDKAGSRETSAQLFCALCRSLGIPARLVVSPQPMPWSVGASKLANSAAGTPADKKPNQLRAKAKTPASRRFASKPVHELTSDDESVASSGSAKRTATRGKAVPHPMGFSSADEASDAKRGTPAKARAATSRREAPGSASSRASRRGNREEPILLDGTASDASSKSAAATSKKGKASARAAAVGESARRKGKAREVDPPVADGDGSEDDDYRPEKWKNLKTPLEVEHKVKLRAFRPKQLKDSELAGEDTTADPVDLQAPPTMWVEVFSKPYQKWISVDPVRSLVRPSGNRHMEPAPFDRQNKLIYVAAFEEDGYARDVTARYTKTLNSRVSRLRPPTRAKGEEDWWTRVVRAMHRPQKLDRDAMEDAELQDFSAREPMPSSMAGFKDHPVYFLEKFLKRDEVVFPRRQIATFQGTPVFSKADVLTLRSSRQWYNEGRVVKDAETALKFVKARGYTLANKRAEEQAKLEGREVAQEGLYAEFQTQLYVPPAVGPDGAIPTNGFGNIDLFVPSMLPAGAVHLPMQGTAKVAKKIGVPYAEAITGFEFRKQRGMPKITGIVVAAANAEMVEDAFWQQEQQDALRQQTKKMERAMKNWRKLINAVRIAKRVQEQYKDPIEGQPQDDVSPSEDKEEEGGEKSRFFAPKPAEGPHSADVGERLDVGVDVDVDVEMADGVETESAAASAASTPRRKGAIISLAQLAAAPAEEELQEEEEEVGVGEKRARPARRSTRARAGPAQYDEREDSEHDPPEAETPRRTRRITIKRPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUP1</accession>
    <name>W3VUP1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00986</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUP1"/>
    <dbReference type="HOGENOM" id="CLU_046931_1_0_1"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="76"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="245"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="431" mass="47838" checksum="2BED54E66DBDDB59" modified="2014-03-19" version="1">MCSSPDLKRNPPVTDPDAGIDIKRPRMLTPTLDAAPSSSEAGPSRLTPPSSSSETTEEENDAESDAEAVPTAAPMLGFSIKYQGTVLSVRLAEDETVADLKAILFSMTDVPPESQKLLGMVKGKQPSDETPLGTIPYAPAALRPRPARTQAEASETTDTAVDAEQACKLTVQVTLLGTPEAGRFRDQVAGGTLSSDGAETVQDLDYLGLPEAEAPKLEPHKNPKYRAKLEKVIQRFSDFPIINPPRPGKKLLVLDLDYCIADTKRLLDPNSPASLGARPGLHELLKAVYPHYDICVWSQTSWRWLEVKLIELGMLGNPDYQISFVIDRTPMFKIQSKVGTHEVKALEFIWRRWPQVYGPHNTIHIDDLSRNFAMNPRNGLKIKAYRNAPNMDTEFFALRRYLLQLAHPSVQDFTKCDHMGRAWKRFQGPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVE1</accession>
    <name>W3VVE1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVE1"/>
    <dbReference type="HOGENOM" id="CLU_860855_0_0_1"/>
    <dbReference type="OrthoDB" id="10556223at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="323" mass="33898" checksum="F4CAD6DA0C2A57C7" modified="2014-03-19" version="1">MGGGPSGFIDGKCAVRIQMVGPDNGGAADAQEMHAFAGQARKAPGSPLWLEHSRSGSGSSASEEAQSQRVDLGAEAGGCTLVGHERGVRGARAAAAGMRLPAWLQRGATTLAPSAANKGDLPPLLSAPSGYASEDNGDNNSMWSLSLLQAELDVASDLSVELEIRTGSGRAKPWDQLQLPATPTENATADKEKEANPRCIPRIETSIQHRFAFHWPDSSGICPKDLHGCDLPFKHAEAARCIHTDVASGSPSNRDEVQGDPASVCLTPGIVEVCICGGALRIQPQNSVVAQWHCCMSIVLSSTLEFEDGRVSRGSLSAYPHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVN9</accession>
    <name>W3VVN9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVN9"/>
    <dbReference type="HOGENOM" id="CLU_1180652_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="235" mass="24545" checksum="1D4699057426047A" modified="2014-03-19" version="1">MGPAKSIFWPVWQTHAGSSSQVDDASVYPRTPPLNEPWPGLDPLKQASASWHRIAVSHLQNLTRSLEIDEGSVECLPASGPAVSLVASASAAAVGAIACVPVPAAGQLCMTWLEASPADPPLLHEPSGAASAAPAAVAAVEIEHLLSRARACLQRRSWSNDCSVCSAAPLLQAISTANARSGPPAFRTSSQLRFALASYPHPTGNPPYFPLVTADPHRVSTTFIASGSSSDRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVQ8</accession>
    <name>W3VVQ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00881</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVQ8"/>
    <dbReference type="HOGENOM" id="CLU_014184_6_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="265"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="349" mass="40409" checksum="2631C98F9887DAFD" modified="2014-03-19" version="1">MGACMSTEQSSDTPEFKKSRALDRQIKEDEKNMSREVKLLLLGAGESGKSTILKSMRIIHHIPFTDEERENFRRLVFLNLVQGMKTILDVMEEWAIDLHDHANVEHLALFVAFPDIAEDEPFPHDYLVALQALWNDQGVQSVYKRGNEAAIPDNMAYYYADLERLFSADYSPSEADILRCRNKTTGIIETTFPLQDRIYRIFDRKKWIHCFENVTAVLFCVALSGYDSCLVEDKDSNQMQEALMLFDSICNSKWFVRTSMILFLNKVDVFRQKIAYSSIKHYFPDYDGDDQDFNAARSYFKNRFCRLNRSPTKEIYPSFTNATDVSLLKIVMASVTDIILTNNLRDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVS4</accession>
    <name>W3VVS4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00837</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVS4"/>
    <dbReference type="HOGENOM" id="CLU_066963_4_1_1"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833452" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="29"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="38"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="204" mass="23038" checksum="798279BABF35F761" modified="2014-03-19" version="1">MARLTAILAAWALALLVVLGLSAAPARAHMIELLPHSSECFFEDLHNGDQMTLTYQVGGGGHLDIDVVLYDPKSRALFKQDRKDTGTYSFTAQDDGRYSYCFSNEFSTVSDKTVSFNVHGIIYVPDEGDMLPIEREIRGLAAGLQAVKDEQEYLVIRERVHRNTAESTNTRVKWWSIIQGFILIAVCSCQVYFVKRQFEVRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVT8</accession>
    <name>W3VVT8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003181_2_0_1"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="742"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="897"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1021"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1088"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="1299"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="670"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1358" mass="147317" checksum="8386A97C852905E6" modified="2014-03-19" version="1">MLAITITSTTLTLAAGIMNPHLPSGATSSATLSNKEKHYAQLAGKLGALATTFDTTKQHLNLAAEQAFYMRKLGIAQASTSIGSRKRHRRSRRAEHPPPVRISSVFVPSFAPIVRKRIPELRKTGASGWLAGWLGWLIETVHVGSASDSWLAALRMRRSSSGVRGRPDENFQIGAHARALTKKKGQKAEKRDPGELQGLAGVNPAEQPTPHRFRQSTHARNTHARTHALDPLTSRSSCLPPSCLRPHHPRRQPPSYPAATLMADPKRATSASRSPSRAQPNSGLTVSTRPPAADTTDNHVDHHNAHQSAPSSARPRLAGRRTMSSKSDTRRLSSLFVPPTTDNAAQPHSSSRLAALSKGISGALSGSASIASLREPLSPIRSFYGGLTGQAIPGSRKRSKQDFRSYDDATFEDEMNLPGSGGNGVRVWYESYTTIDWIHDAIKESSRLRRIRNLRGIRGFAINSWDRLQGWIIVTITGIVTALIAGCIVKSEAVLFDLKDGYCAKDWRLAKRFCCPYGNAPDWDHPDMASASASASWSYRTRFLPNAAIPTSPADALQSLVSGVGVGNRILSGWAAPVAGSPAWHRQPSFPSQHANASLSAMLSPVDSETEDCPGWISWGQKFGSTDSHNWAASYSMYFVVAILWASIASILTIYLTSSELYLKDPASQSSATANLNQKPSSSSDGDARQHGDSSDQEPTETSALLPNASSGANRPDRLHSRDFARRANEQRASKAILPRKVLYFATGSGISEVKCILSGFVIHGYLGFWTLFTKSVGLTLSVASGLSLGKEGPFVHIASCVGNIVCRIFPKYENNEGKRREMLSCACAAGVAVAFGAPVGGVLFSLEEVSYYFPSKVMFRSFFCAMVAAATLRAIDPFGTGKIVLFQVTYDKDWHFYEMLFFVLIGIFGGLYGAYFTKLNMFWAKNVRAKTWMARHPILEVVFITVATAALSFFNGYTRMGGVELIADLFSECHEHESLEGLCVSQPSQIKPLILSILFAMVLKGLLTVVTFGIKLPAGIFIPTLAVGACFGRIVGLLVQYVQWTHPDLGFFSWCPASDSACIVPGVYAMVGAAAALSGVTRTTVSLAVIMFELTGTLTYSVPVMLSILVAKTIADALEHKGIYDLVIEFSGLPYLDSKTEYIWNGVNVTDAMETEVEVICLDAFNSLQSLADKLDRLAQGSGYTDGGFPIVSRVATATSSAMPASPLLSASLGSLTDAAAPSPGSDSAYQMVGYIAASELEHALTRAVRADAEMRPEVTRCSFNNIPFVRAENEGEANVRDSVLFTASDPLDLSRYVDKAPITVQIHSPLELVHQYFTRLGVRYLIVVDERGLYRGVIFKKSYLKFLDDLEKQSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVY5</accession>
    <name>W3VVY5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVY5"/>
    <dbReference type="HOGENOM" id="CLU_004747_7_1_1"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834929" description="Cullin family profile domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="627"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="989" mass="110096" checksum="1187DC18AEE84D68" modified="2014-03-19" version="1">MSAGSPSAVALFLPLGWAASPLRVGVGQAHVILASCGPLNNTFSTPYPHTPCIGQARPTHLPTLLLPSSFLCLELPRHRIGPRTAPHRVSTGRSSTHRLPKRPLQPHRAVPRSIADAMNAPGSMRRPGGTRGTKLKPPKKPGLDISFEDMWLRLAHAISQIQNHNISKLSYEEHYRYAYNLVLHHQGDMLYRGVKKQIQAHLDRLCREKIIPAFPPGGAASVSAGIILPESLLRQSHATSASSPQSRADSDSAAPSTSAKGKAKAVENDDPTSSAAALATMSATQAGDRADAVARVQAGERLMTAIRDTWLDHRSCTSKISEVLKYFDRAYVELHKVPSINRLGLEIFRDSVIRSAKYPIQIYLYSTLLTHIQIEREGSAVSRSLVKSNVDMLADLTQHKPGAPPDEDPSVYSIDFEPAFLQTSAAFYSAEADRWLDAGDAPKYLAHVARRLNEEADRVSVYLKPETAKPLQQLLETHFLARHLATIIDMPGSGLVSMLDQHRTDDLCRMYTLFHRVADGPHKLRLGLKSYIAAKGKLINDAVASQTAAAPSTDAPVESSTAKLAKSKERESDASTPQAATAIRWVEEVLEFKYKFDAVLEGAFANDTGCETAINEAFESFINTNKRAPEFISLFIDENLKKGLKGKSEAEVDEVLRKTICVFRFLHEKDTFERYYKQHLAKRLLQGRSVSDDAERGMMAKLKVESGHGYVVKLQGMLNDMKTSEELMEEFGRVVKRSDRGMPMGLGVSVLTSTNWPISAQAPSCVMPEEMMETRRRFEEFYASRHNGRVLTWHANLGSADVKVAFRARSHEINVSTFALVVLLLFGDVEEGVALSYGDISKRTMISDSDLERTLQSLSCGKYRILLKNPKSRDVNNTDTFTFNSSFTCPLARFKIQQIAARVETPQQRQATSARIDEERTVLIEASIVRIMKNRKQSTHNDLIQQTVAQLSSRFHPQIPHIKRRIESLIDREYLERSPTDRNTYIYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWV1</accession>
    <name>W3VWV1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box protein Hrt3/FBXO9 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWV1"/>
    <dbReference type="HOGENOM" id="CLU_017706_2_1_1"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box protein Hrt3/FBXO9 C-terminal" evidence="3">
        <location>
            <begin position="658"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="838" mass="91506" checksum="C5A107784BEA45C9" modified="2014-03-19" version="1">MDRPDTAASVRTPPPDPLSDPLSDPDPDDDARQHDSPSSTPLADRSGSQTPLEPQSHHAPATAKAQSSDLVDDELERFRSEWKKEVEARGHLTYAHPSHPSANTQSRPDSHTAHTSTSTQLHPAASPSAASEAHAPLSHMQQQDREASDNETDLASDQRTSALPQDHSLPFPEAEIYAPAALKYSKAAHKLPRRPPPPPPSQSSHDLPSPLVRQEFHPHHSSDQSIDGSVSSATIRASAAPFSSSTSSSHPLAPKRQPASETPSQPSASSSSASSRAPHIIATHDAPAHASEATQAGMRSAVEAYARAVEMERSGQLDQALESYRRAFKLNSHADRLYHRAHLLLTDPALANSSTHQNDALLSSPAIADKVRKALDFDDHRYVAIKERQAKEAEAKTRGLSYNGTEPYASLDDRTAIGAPPTSTERQDKAHESRPDELAKLFDSMSIERGGERDFSTIALAPEDEEKTMPIARLPDEILLHILRMIIAPRGRRGAKVVKIKPPPEEQAAADAAAAAPTGRSTAKPNQTTGAASKPHKPVSAGAASSTANGVYTAPDPSSTGKETGSNNAKADTRSEPQSGEHDKDKASEPNAAGVIARKQPLGIGVVLGGADWQSLEMLGRTCWKMRLLTKAPSLWREIVRETYYPPILDAAASLASLYERHHSDWRTVFINQPRVRFNGCYIAACHYARPGMSEDAWIRVIHVVEFYRSIRFLPDGTALSLLTTDAPSETVRKLEPGLKAKGFSKGRWELFEQGLEDDEDEGRPRGPKVVVEDLRDKSMQKYAFRMVFGLRSTTRGRWNKLDLLEYHSVNLTNGEVLPLPQKHSRPFHFSRVRAYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWZ2</accession>
    <name>W3VWZ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWZ2"/>
    <dbReference type="HOGENOM" id="CLU_339511_0_0_1"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="790" mass="83262" checksum="45309A446D1D8E9C" modified="2014-03-19" version="1">MAATAAASSANKRKPSFSDESDSDSDSPSSPSKKHSATSTAKQSASQQLVPVPGQPDAPLVTKRTLQNRKAQREFRKRREARVRELEERCRRFDQMGLEANTELQRLARNLKEENEALKSLIARLGFAHMIPGVLESVNAHDQHHPHQIQHSQHAARHHHPQSFAPLDLGMEAWARQPAPASSISAPSLHQPGAPVPASALDQNSAATASITKQSKRSRGSTSATNTSASAATSSLSHMPAFTELLPTTAGNVNPSLLSDTSSHPSKHSLPGTTAAIAIPATDKSTTTARPIHDNSTFDNDWFAQLAQSGHDKDEADINDGATKLEKSTNSNTLPNDRTSINPILSLNLGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDSKPNAKPSDALNANSALTGSAMLGANARDFGLGLASALGIPASSAPGSNIFPMPMPTHQNGALLNPNPIPFAFNLSDNQAPGDQSWWSQVAGSVLEGDDSVLDEKAQAVAQATGTSNNGAPSPFDLSAFLNGGLTPGGGFTFGSQSNNDTDDAHDPQKSSSASSATFPDDAVKPNNGKAGETQSLTQAEHAQMFLRLLEAKMAKRDPSPYAQLGFQPPTHQQQYAASHQAGPSFSDASSSSSASSSSNDKAAFKQDDDSSLSPINVYSRLAQHPAFLSTNASELEELVDSISSSQHQRQQSQSLFQPPFNKRRSSPAKPAPALYPPSASGLTPSIYGPNGAAALASRSSSSASSHGGKDLEVDENAVTKMLGLLDRKTSREAATAGGGGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWZ9</accession>
    <name>W3VWZ9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001695_0_0_1"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="TerB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1087"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1137"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1270"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1057"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1087"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1146"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1270"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1313"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1359" mass="144118" checksum="223047EA45E8EF2D" modified="2014-03-19" version="1">MSSSHKSAAMAADDDDEWQSMPVESAEEKGASIPIQAYSNPYDLPYGDEEEDDSDPDDPRRFRSLPPRSSARSQPHRTASAQLHKRSNAKSQYLTDPGKSAISSTSARSHNTATNATGKHLDIDDARGYDWRSKPASKDNADDDDDSDGEKGYTQLRLDEDEEAEQLHAATEYLFQDGSRHDPYGDNTSATPLNQMKTTKQLLSEGQKIAYVGLCSLIASEMVRQLRRVPGKNLDAAKQSIEAWKVKVVARLYQHMDIESSEQRMIESLAEHGVLATDLAPSLITTQTIDNPDFDPEALRELQEEQELEAQQQRQPEQQKASSQSTPADQTSNAQPSSSPPAEPSTTHSDQDGLDEAFDGADDGDIGSALQEKPRLKTEAVTGDGSQSDQSGPFKARSKRNAAQDDDEVDIGMQQDTPPADADDGADITSANEALRQVAKHHARSGSQSDNTSTAATATSRPTSMASATTTVVADPNTASQLANAVDATEATVAPTDAEVGPGSVTTTLGLTKEPQAVQPPPGALDGVTTSISSADATITLDLRWTVLCDLFLVLTADSVYDARSRVLLERVASELGLTWMDVTQFEKRITDALEIEEGVETLSDPSAVTQRMLMARKKRMVMMGLATVGGGLVIGLSAGLLAPVIGAGMGAALGAVGISGTSGFLGGVGGAALITSTGTVGGMSLAGRGMSRRTRSVKTFEFKPIHNNKRVNAIITVPGFMSGPLDDVRLPFSVIDSVMGDLFSVFWEPDMMQEMGNALGLLWNETIVQGVQQALALTVAGASAMFTALAWPLWLTKLGYLIDNPWSNALDRAQAAGLILADTLSKRQLGVRPITLVGYSLGARVIFYALVELSRMKAYGIVQNVYIMGAPVTAKDETWKEARSIVSGRFVSAFSRTDWILGYLHRAASGGLRSIAGLHPVERVQDIENVDVTHVVPGHLGYRPLMPLVLSELGFRTTADYFDEPEDLNAIPERQVVQEAAAEKVELKTVTTKTGGFGRIFRRKDSSQAGSQSTTPVRSQSAAGSATGATATAGHAEYDEYDDDDDDLPPRMESTPPAAEAAKAVTEAKQTQEQIVKQSIARVEAVRSSHNEAERAATPEADRPSSLSAHFDTEAILRELRESGIEVKELESSLPPLPLANATQASKGSSSAEHSGAAALASGNSEGGARSEAAAAPSNGGVSLTFASYDDDIQLASSPVQAESAGSNVTGKYGLSSSAAQDLETRFKSGGDAPAFSGRTSAMGEDAWVRGEEWGLARPDTSYDMSMGTKSATHSLPTSSSLGFGEALTPGERSLDALTPPSAAVGRGFDFSSALGTASGSSTADLAARPSPSSERAPRRAGDATLGTEPDPWADNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDD1</accession>
    <name>W3VDD1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDD1"/>
    <dbReference type="HOGENOM" id="CLU_013387_2_2_1"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150149" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="33"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="167"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="5">
        <location>
            <begin position="416"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="495" mass="53926" checksum="AF13334AF5A8C21B" modified="2014-03-19" version="1">MTGLTLTSVLTLMAATAANAYTYPNIPTDKTTPTQTRLAFQELNAVSVAWNTYEKLEQSCVAYGTSPTSLTQRACSSDSSTYPTSRTWFNNVLLTGLAPATTYYYKIDSTNSTTNSFKSAHKPGDQSSFAVNAVIDMGVYGADGYTTTKKRDIPFVPPSLTHSTIDQLVQSADQYDFVVHPGDFAYADDWYLRPQNLLDGKDAYAAITELFFNQLSAVSAYKPYMASPGNHEAACKEVFYYQGACPLGQYNFTDYNARFGPTHPTTFGTASSEAAAQSNATAAQKLALPPFWYSYDYGMVHFVSLDTETDFPSAPDTANLGAGPYGRPAQQIDFLKADLASVDRTVTPWVVVLGHRPWYSTGGSDNICSECQTAFEDIFYQYGVDLFVAGHVHNLQRQQPTYKGTVDPAGLNNPKAPWHIVAGAAGNIEGLSSAGTIPAYNAFVDDSHNGYARLTFVDKNSLKVDMIHSTNGEILDSATLTKSHDQQFVRQTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDN1</accession>
    <name>W3VDN1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDN1"/>
    <dbReference type="HOGENOM" id="CLU_1797288_0_0_1"/>
    <dbReference type="OrthoDB" id="10538853at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="144" mass="15091" checksum="448743EA21426C9A" modified="2014-03-19" version="1">MWDESWWEGREAGSDDQHHTLVSSPDAEGIFVFDIWRASSTQLEPDAQIGRASLAQGTADGSATALSCDSLRSPEEKVGHVQAKNKTRCTGSPSAPMRILVPAGWGQAAPSCARKPSVSSAAGQPVKEGLQASLEATGDASVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDV3</accession>
    <name>W3VDV3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDV3"/>
    <dbReference type="HOGENOM" id="CLU_019845_0_1_1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="80"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="468" mass="51428" checksum="733C82DFB161E918" modified="2014-03-19" version="1">MGTAVSELQTFSLLGVTARRHCSARAGASSYGLRTTHVRHASLDSFRSRNTVLGLFSCVIATFAVMTFDMNLPAPGAKKTIAVLGASYAGHRAIQVLVASLPEDWRVVVLERNTHANHLYAFPRMSVVRGHEQKVFIPYTNMFKPALALRDQHQLLHANVLELDQQNRRVSYELINDKAAGVQWLQWDYLVYALGSHLPDPINVWSSSGEQGSRQHDGSKIMGVQWLRDAQDRIEKAESIVIIGGGALGVQLATDIAVTYGRSKRVTLTHSRAQLLPRFDPWMHEKAAARLSELGVELVLRSRVDLGSLSSDRRSFRLLDGRQLEGDLTLFCLGQTPNTLLLGESSLSESGMARVERTLQLSSNPRVFVIGDAADAFGAINAGHTAWDQAEVAAKNILTLISTKQGQEAAELQEYKPTPPAIKVSLGIDRAIRQTMGGELIEVDSGVIDLNSTSMWTRRGLGTDDLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDV5</accession>
    <name>W3VDV5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002074_0_0_1"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="1066"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="1377"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="6">
        <location>
            <begin position="1578"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="860"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1328"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1527"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1827"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1349"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1834"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1854"/>
            <end position="1864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1864" mass="199934" checksum="5E5DF3063D48D4C6" modified="2014-03-19" version="1">MPVSSAAKLASHIWRGAAQSAANAAHNSANTFRGAFQGASGSTSSTGSSASGWASGLSSGGSSAGAGAGGAKFHAGRGAYHSYQHTGRVLSQASTSSGNDANSKSNDDEDEIRRQKAYKLRLDGHLPTLASPGHLTNSHMQVRFRHAFAANHAPLLLTAADGTHADQDANTAAQSTRHISSSAAQADAASVEASQQQANNSAAGFSAHDRLYKALRHATARRDAAQIRDTVAAFNALPKEQKTTKGYNMVMESLLSIRHTGQPVREITDTYNAMLQEGLSPNSRTYTVLVKALCALDAETHGAQTFNAAEPRATAPTAQDAAESTTTPAADDNFGQALELMKVAHGGRLWFDDAHAYNAMLSSCALRGDVDSALGVLDLLERSLFANTDATTFKHLITTFVTDPQLKQSETHQMHEARKLTACKQVFDEFLLASQNPDWNHDRDAVVWCSLIDAHFALNDAQGAVRLFEKMLEGGDNVPALDSHVVSAMIRGFLNIGDVTTALQWFTKLTPAEDMQSSQAQSTESHMPRPTHSTVEQLIVSLAQSGNDELLEPLLRVFQTYARTLFKPHAAQFAVLANVLTAHVASVKRMTDAGAKQDDTNAVLDRALEAASSYFGCLQDSLHFYDPIEYPHATQQIVEAFFALSDALMAAARHVDAGSALSYVGFFFDRLDLTTAEFATLTEKLSQLAASFLAADAEAQDANAASLRLFAAAQYVVPLLRAADRLDESTAQALTTLYRSVHAQTPEAVPSLPLSADAWTLVLEAFCFEEANLRPLSLDAFKADGIPMVLNDLAKLPAPEAAAEAAPSRPAVDLTKAAEVASSRYGDEALALFPDWATQALAAARNGAADGAAAASATVETTSDVTASESQLSGSTPASTPPRKHSPLQRQDLPAPALSNANIPFFPPVEVVDTDFGQTLFALARPSGQDGAPRVYGDVRKQMRAGVYAHPEGLAQLIGAFGRLGDVERVEELYAMSQHVLHALAGDARWQSKAWFYVEDHMIQALSHAGRPEAATAHRHRMIAAGGSPGATSYAALIATIRETTDDATIAQELFEESQRFGVRPTAYLFNVVISKLSRARKADRALQLFDEMTQTHGIKPTSVTYGAVINACTRIGDEQRAVQLFERMERDPSFKPRVPPYNTMMQFFIQSVPDRERALGYYNKMRAADVRPSAHTYKLLLDLYGAIEPVQPHEMERVFDELASNPAVNVQGTHWASLINCYGCVLGDVERAIATFDSIASHPSSAGRKDGASLPDAVSFEALLAVFVAHGRTDLIRAHLHKMERAGIQMTAYVANLLIRGYSMERGDAGLDEARALFESMDEPAAGVAAAGNHPPRAHGAGAQESTAADASPVANAPASTRGSGLAALFASVQREPSTYEAIMRAELSHGHADRAAALLERMEARAFPPALILRAQALLKEEGATNTAADEPAAQNKMPFESQIPAPLALSEGRLTFGQTSPRLHIASERGGAMTSVRHASTMAGAATAAGTSNPAPGAPKPNSPFTIFDRAVKTAQKDRAAVRPSVAADAQGHAFGAESTRGEASRQTDYVRRAIAESLAERVQDIKRDFGTIVELGAGPGLLRHYLDAEGSGTKKIIMCDTSEALLNRDRHLDAQFPFEVERRVLDEEMLPFEEGSLDCVVVSGGLHWTNDLPGVLIQIRRALKPDGVLIAALCGGDTLFELRTSLQLAEQEREGGISPRISPMADTRDMASLLSRAGFTIPTVDVDEVQVGYPSMYELMHDLRDMGESNAVINRRGQLRRDTMLSAAAIYEAMHGQSGGETQQPQGVPATFQLIFLIGWSPAPTQPKPLKRGSATSSLKDVLAGSEGDVQGHAEAEMEHRQRAQWMKTMAEDPTKPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE55</accession>
    <name>W3VE55_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_05890</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000013">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001752">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="16">
        <location>
            <begin position="1112"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1290"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1331"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1380"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="852"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS59918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1687" mass="182994" checksum="3D8B50D79E1D01D1" modified="2014-03-19" version="1">MPSKAGTKQSSLLGFFSKAPASQIPARSAASPPRSAAGPAPASKPDSKSVAKAASPLNKTKGQAQALDTPPPSEHRSSSRASRSDAKSAPNSAALEAPSSSPTYHRSSSLSTDNLLPTTQAQAATKPRPSKTSDSEELTPPPSSDAGDMDIDEDIDEDDEVEQPLFRRRAVAKRPVTYAESDSEGHAAVDSDSEDDMPTRKRSSAKRARRSRDEDDFIVPDDHDEDDDLPMDAAAISDEDDAPAASEESDADDFAPASKRSKVKKQTSKSSSSPPASSRPGPTSALSNFAMGRGASGSSPSVGRNGASNGGPRSGPSSASLSHLTKAERRVIEEKRKRAENEQAYSFLVDLRDKDGNRPGDAEYDSRTVFIPKSAWKDFTPFEEQFWRIKQNHWDTVLFFQKGKFYELYEEDALIGHREFDLKLTDRVKMKMVGVPEASFDIFAAKFLALGYKVGRVDQTETAVAKGMRVGERSRGGGSEIVNRELRHVLTSGTIVDAASLPDDLNSYCVSIKEDASAGRNGPLFGVCTLDASTAEFNLTEFEDDESRTRLETLLRSLRLKEVLHEKAGLSPQTLRVLRSTVPSTAQITMLKPGVEFLEPETTLRKLNALFNPDVDAEARIEALEPVDPALLPEGIASMVDRACAMSALGGMLCYLAQLNLDRDLCSSRNFNIFDPLKQDKCLVLDAQSLTHLNVLQNDEGTEEGTLHRLLNRCVTPFGKRLFKIWLVAPLATADSIRARQDAVEDLLKYPGFGDEFETFGKTLPDIERIVPRVRAGKCRPRDFTAVLKALTRFEKFVRQLRAQCDGFETAVISDLLDSIPAVSPIARELQSSFRMTEDGSFNPIEGAFEPYDRAEAAIAKVEAQLEHEIDSYRKQLKLTSAKCAWKHLGTKDIFQIEVPVSTKVPANWTKLSGTKDRNRWYSPKVRDLVQDIKEARETRLAALKQFHQSLFASFSEQSDVFLQAVKTVAEVDCLLSLAKSSYAIGEPSCRPELVEHETALLEFEELRHPCIAGENVDFIPNDIRLGGKNDEVAILTGGNMAGKSTTARTSATAVILAQLGCRVPAASARLSPVDRIASRMGANDQIFRNNSTFMVEMLEASRIINECTPRSLVIMDELGRGTSTFDGQAIAFAVLHHLVSRTRCLTFFLTHYTNLAYDFDSYSRVSNKHMQVLVDDAKREVIFTYRLVDGIAESSYGTQVAALAGVPHEICDRAAAVSKQFADATKASQAEKKGSAIPLALLSDFVHLVKLAKQEAPASSDRNAEAKARATLSQLDIIRSQVAALSKRAAPAPLTSGIPAGSEERTDATGQPSEPVRTAAKKVTTYAGRNRRALTEDPLAPTNLVSSNADEDEAMPKAQSSPILGATLTPLFPTMRAAKTANRKAGPKPASTSSAREPEQLILDLGQRIRIRCAECDMQYDSSSAEDCTLHARHHERTVRGLDWSAKALAVWGEPVAQVTLTRPATKTALRGKQVRGGATGQSEAVTIRCYDMATLKDAVANRKITELLETVDEALGAAAMDAASVRTCKVLVAVCEGRAAGAAVVGRVPAGQAREVLPSNTDKENCTTDEAESTRAGTVWNDAGDAIFVSDALSASQTPPVGVHRIHVIASWRRTGMASALLDAAADNSVYGFDLQGLIRTYGSRAKAVAFSQPTEAGRQLAEAWIRKGAPSTTSSPTRLIVFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEE2</accession>
    <name>W3VEE2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEE2"/>
    <dbReference type="HOGENOM" id="CLU_448484_0_0_1"/>
    <dbReference type="OrthoDB" id="3354346at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="618" mass="67464" checksum="27B82336EE8DB1B7" modified="2014-03-19" version="1">MSKPIPASWRRGSGLSESPSFNPNEISSGVETPLGTTDNEDGMAYLRSMSYVHTSGRFSSYSLADDSRRGSAHNTLVNPSLTPTDYASSENGSHKGVKVDPLAKKSPLRASNSWDGQAEMGQVGSPLTPEAIKKMKYGRLRYIDGLRFVAAIVALTSTVISTTSQNWSVGKSILYPFNSYFALTLFLAIQGRALTLPWLVNRKDAIKSFTDAAAKAKAAKAAKVPAPKALDEKATPQAVQAPKGDSGSQSGINTPDYKLVGMAMISRPFRFLLPILFVTGVQYAICQTTNLYPDNPNFETLIGTRPGWCFRNASQWIITATNLFTLEDRPTELRSAAGPIFYLPWFFQNSYYLYGLTLIVGILQRDTRVAFLLVMGLLNWCTLSYLAPALLGLLVAELDVSGHFARLRRHKVASWVVQGLCAALFLVFLLVPQVRDPMNDGLSHLQVLRPSDRQGANIYSVIKFTDVICSALLLVFLELSQVSQRVLSLAPVSMMGQQISAAIVAMHAIVLWSIMPKVFPMTAASSVTSGAATNLAGIWALTLIITLALSVLFRVVIEIPSELLGRATLIFFYGQDDIQQLSTISPQHMEKARKSGYLMPLPSLGNPMAKLGLTKVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF42</accession>
    <name>W3VF42_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF42"/>
    <dbReference type="HOGENOM" id="CLU_090376_1_0_1"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="212" mass="22953" checksum="DE0D398C174A18C9" modified="2014-03-19" version="1">MNAGPQQGPPAPTAEQLAITDAGFQHVPLALDAETGTLHTPVPDLDLTVLNALIRSIKGLPPNVAFPPPPNAIAPQRSMAINQAKEQGNTAYRNKDWAEAVKMYTLAIDVAASRPLWEANQVARDELSLCLANRSAAFASCEDWIGALCDAEAVTKLKKPWAKGHYRKGKALVGLQRCKEAREAFELGLQFDPDNKDLKQALAELPAQKNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF46</accession>
    <name>W3VF46_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF46"/>
    <dbReference type="HOGENOM" id="CLU_027634_2_1_1"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="50"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="255"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="294"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="363" mass="38114" checksum="DB0800F9D296EC2B" modified="2014-03-19" version="1">MATSSSSSGRSSTFCLVKSSINIDETFLVPHIVRPGETISSSGLVSRPGGKGANVSAAIGLAGAKVSLSGAVGKDATWPIDELKARKVITDDVEILDGVPTGRAFIQIAEDGENSIVLLKGANFATDSSSADPSTAFTSNPQRQITHLVLQNEIPLQTTVAFLEYAKSDKAGNHITTIFNPSPMLSNAQVESFPWSSIDVLVVNEGESIELLSVLDQSAASKLESLATGEDKSRQVLEALSGLKQLSSTAWLVLTRGGQGVMANVQLADSASQRSFFNIPPFKPKQVRDTTGAGDTFAGNLVAALMGHNVDADEALTSSARPKREQFVKQALEWASRAASLACEKEGAMQSIPAADEVKAQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFJ4</accession>
    <name>W3VFJ4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFJ4"/>
    <dbReference type="HOGENOM" id="CLU_634796_0_0_1"/>
    <dbReference type="OrthoDB" id="2556722at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833117" evidence="1">
        <location>
            <begin position="25"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="396" mass="43510" checksum="858D9C4A3147868F" modified="2014-03-19" version="1">MLLSFLAKCHFGVLLTVLFGTAVSQPVGSYEWTVGQVPTHGQEESTLFGAEHGWHSVHPEAAFPNSPGAWSSGSVAPAAINSRWDGAQAVGSSQAPAVGSHAPAPAPFHPHVLESQGAQLHNGFASSSAAHPIDWFADNAHHAFGVRLTRMLAAREAFGGDRRQWETWSEHMRRAMGSRELQISPVNVGDYGYDRVFIAQDGHAVSGFYPPLTQALPRSPSARHLLGDIVPGKLEGEREVVGSRDRVYVYLNSRVNMDYINREYFLGHAQFLPIQPEKLSRKVINKVYAVRRNTVVLPPRTPHGLPLLVIRHTGVRGVSEGLEAITGVGGDMQRMSLWSPVLYDGKRYTTVLYGVVVMDPRHNEEVLAHLLRQNALRDSSTYATLYALADVAHEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFR2</accession>
    <name>W3VFR2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFR2"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="51"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="253"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="708" mass="77426" checksum="3DE05F5FF2FF6A2F" modified="2014-03-19" version="1">MTAPPTFWKPGSARPGSSLDRDSEAEPALLTSAAPSSSSSLPVAAQRDSILYALERHQVLIVVGETGSGKTTQIPRFLYDAGWTTAAPASAGNMIACTQPRRLAAVSIAATVAAQMGVRLGHEVGYTIRFEDNSSAATRIKYMTDGTLFRECIKDPLLTRYSVIMVDEAHERGVHTDLLLGVLSKILRKRPELRVIVASATIDALTFKDFFEDSRIVSQADHKHEQDRATVVQIKGRSFPVHLAYLDDPCEDYLQKTVDTIWNIHLAEPRGDILAFLTGRDEIDTALQLLADRQLDLPDSAARMHLLPLHAGLSASEQTAVFAAPPSSALRKVVVATNIAEASITLDGIVYVVECGLVKLRATTGAGRDTLGVVPISRASAVQRAGRAGRTREGKCFRLYTERSLEQMHASTPPELTRVDLAAPVLMLKALGIDNLARFEWVPPAPPPALLAAGLQRLVQLGALDEYARLTERGAVMAELPLPPHLARILVASAEPAFACAHEMLAILATMQVSTLFVSPHTPQTQLSQRAFAAQQGDVFTLLNVFLAFTDERVGRKSAKWAQRHRLNFPALSRALSIRQQLERFMVRFGLDAKCSVRGREDAVERITRCMLTGLYANVARYDPVRMTYTTTAGHKAWAHPDSVFFNRRPEADWIAYGEAVQQATPDGTKTYLRDLLALPDLEWAASAVPGYYTLSTQWGHGTNSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFS3</accession>
    <name>W3VFS3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFS3"/>
    <dbReference type="HOGENOM" id="CLU_046550_3_1_1"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001664">
        <property type="entry name" value="PRK00431.1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="220" mass="23443" checksum="31D7E999E0341E6C" modified="2014-03-19" version="1">MTTALSSIPTLASLYTSTLSRPAASSFASSIYPFSSLLSVHCGDITTLEVDAIVNAANTSLLGGGGVDGAIHRAAGPSLLAECRRLNGCKTGEAKLTAAYDLPAKHVIHTVGPVYSSHDPAKAETLLRNAYNNSLEECIKAGGRSIAFPSISTGVYGYPFDKAAAAALDQIGQWLEHDNNHKSIDRVVLCCFSQKDYSKYLDIAPSYFPPQDMFDEYAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFT1</accession>
    <name>W3VFT1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFT1"/>
    <dbReference type="HOGENOM" id="CLU_706212_0_0_1"/>
    <dbReference type="OrthoDB" id="2558149at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833122" evidence="2">
        <location>
            <begin position="27"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="429" mass="46887" checksum="9C4827CA539A92C3" modified="2014-03-19" version="1">MAPVCWHAAAVFFSVVLSLFIVEVASLPAGSPDSSWSAGSNFVPMDEDDSITSAHSRNGPSWHHAPSGQHEGLPQPWHHDPTDLHQPAWGVSGSAPVLPHQHDPAWVPAPTGPLDDLDHMILDHLLNDVSAAAPPSGQGNTARLLNHLAQAKPGDILRQSGHREFPQGLRFGKPTANPSSEPRPDSPGQASSSGSPRSPQTESDSFRHGMTHNSLPDNPLSNAESSGAPAIIRPLSPDPPHRGRYPISVEPPINLQKIVETPPSLPPLSVAEPGASTYRRYAYPYAASDTNLRSVINNRVFDGKLHWVNPMEVRSTLRKTHFRGAIKANRVLPYVVDPSTSPAHGGSGEIRLAIHKVHVFPKGQTHPIPTRTYYTMWSYPPRSNWKQPEIRQIGLGYLEPKDVDHVDGHLDLMEKSNEYRDAVLSRIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFY3</accession>
    <name>W3VFY3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFY3"/>
    <dbReference type="HOGENOM" id="CLU_069491_2_0_1"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21182">
        <property type="entry name" value="Tudor_SMN_SPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="237" mass="25474" checksum="C02476D2C0D4ADA8" modified="2014-03-19" version="1">MDAAELEAFETQLADTRTALQSDSDNADLKALRDELVNLIQLSKSIPTDNAIGPPPPPPEPSPSPPPSAPSGSRMSSAPSPRFTVGQQVNALYSDRRWYPARIVSLSGDPANPLCTVVYTGYGNSETLPSSSLKPLPPQPQDPTPPPPPPPPSDSALPPPPPPQPRPPGPLDDKTRKKMRTEKKIARREHQSAIAQAKATSWQTFSAKSKSLPKKSMFRTSDDPYARVGISKSPKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGE8</accession>
    <name>W3VGE8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGE8"/>
    <dbReference type="HOGENOM" id="CLU_000315_2_8_1"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="266"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="774"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="941" mass="102228" checksum="C62E80A1BAEF4AEE" modified="2014-03-19" version="1">MEAMRRKIIEEQLAAIEQAKRQQQERQQSTTASSSSSSSAANPAVTLLPHRNKHAPPPKSQSQSQSQSVAAFGGAGSGVGSRTDPIVFGESSPIGATRSNPFQSAAVKPSTSASSSSRAPARPPASAATSSYAAAQPFRSPNSKSSYAPFISPSNTPPPPPPLRNNNPFYHSPLASPSASRSKPLRQPYAYDDHMQSSPVHTIYPDDTAVGPTIDAATRERQIRDLLSNMVNVTQVSDDAKTDAHVPGLKCMLLPHQVQGVAWMREREKGAAKGGILADDMGLGKTVQTLALIVSNRPGNDKATIDLDVPAEPTKRGKKAAAPKNASLDEAQDELEDAARKEMPSKTTLIIAPLAVIKQWEREVTEKTDAGLKVYLYHGPSRTKSAAHFAKFDIVISTYTTVASEYNTYMAALEARAKGVPLTKPAAKSKSRTGAKSNAPRTTADSDADSGSDASVVAIDSDDTDDSFARAPAKPGKPAKKAAAAPLFDFSWLRIVLDEAQNIKNHKAKCSRACFMLAGRAVSRWCLTGTPLQNDAYEMFSLIHFLRVPPFDEYAHFREKIGEPLKSANQNRVNWGMKRLCFVLQTIMLRRTKDAKAQDGSPILTLPKRTLQLIELDFDSDAERQFYLGLQERIRKAFEVENGGQGKTNMIASLVLLLRLRQACNHPAMVTGNLRTDAGAIGSAAEPAPGKPAPSTMEAEEDDDDGLAAMLSGLSVAVKRCEQCQVDLPPGATPSTLDAARRLLCAECTQLAASHSHDLFAASTGSTKIRKMLSLLTSIRAADAREKTIVFSQFTSFLDLVEPHLSQRGFGYVRYDGSMRPPEREAALERIRSDAATTVILISFKAGSTGLNLTACSRVILMDLWWNPQIEEQAFDRAHRLGQVRDVTIYKLSIKDTVEERILRLQDKKRALAKAALEGSKLVKGNRLDFKEIWFLFNGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH27</accession>
    <name>W3VH27_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004907_0_0_1"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1341" mass="142978" checksum="C3A1DDB3BBA46621" modified="2014-03-19" version="1">MQSSAAIDDALTAGAKLSAHHNIPYTRDIWARATATRVSACLSAAFVLALWYVAYHALVGTRASSRGAKPLWQLSTMLADDASIDRLDTELDSDEYEDEHESRASGFLANARERHALRRMLARNEGKRSSIVRITSSDPSSSLSDHPMQVDLEPPTRRSFWPAPASSTPPSDSAASSPTSSTPPPASARRRKESGRLAAAEPGRRQHTASPSRSPTLLSGSLPVRPTRIRPVDRSPLGRVASRSKRNGSPSLGTDAADARDASPSPTSPLAEDWADESQLSPTAASGADHEALLTTPSLASEASFTSAIPASPASSTFSLRAPSILKRRPQSFRTASLRDIDISYSLMQRKASLPALPLADIQQQQQQHDFWHHAAMHSSPAPPPYQPSSPDASHAAERSVKLIEPDWRPHLDSHVRAQERLEAATRFATAQGTDGDFWFERFTQSTAAAGRDWDWRKRRARLQRAAALGMALGQSGLASPAGPLPGNVGKTDVQLQHQLGAQPTPAAQAASPVRKVLPAAPLITFSEHELKSAPVLKVDTESGRRPARTSIDATSPTYSATPLSPTPSGTGTPLGGIFGAVLPSAESVSAVMAARMAQRRRASDDATASSAMPAAGDATTMRRGVVDKAMRRRLSASTSSAVPSSPGASPAGSPSIEGRGSPLREATSPFSSDAGRTSMDTPSSPGASAMSVPGRLSSLGTVGKKVSLTNLRAGLRRGSGSTDFMHDASGIELVPNSPELAFDAHTHADPAASPSPEGPRSSADAYSAPDPLEDIVLSRTDSQLRHADGSDGGGPKQRVPSESPQAPPQFRGGARVTKLGSAPAAVLNRAPYDVVEELRQDRERGERGERDSISQGSSDSDSLRRRLRSQTDSAARARMDSVLLNSSPTARRDGPAALSAGTASSPPTAKTRARGGSRSSIVKSASGASNHLDRSAMRRSSMRSGSDSGSLASSTSLPSMARRRGKDATPDPQLQPEPAPRGMAQRARSASISSNASSLASGSRKSSRSNSFRETAGLGMTSNPGTPGSPEERRGDPFSLTPLHAQQPVSIPAVRCFSVSAIRQSKPASKEVASKEAVSKGSSKPLVRETSESPEELNSRPLPYLSFALGVPTPPSATKPTWSERREKLISHDHRMASRKAIVKEATRGYFHDFHAIKSHGGKTWRAPNTLIKDDRALWFPRVEGTRLSDKNKVNTVDMLRGKVSIIALLGSKISEEHTRSTYKQALDTFATHPAFQLVQINLQTNPLKSYLVSLFLSSLRTQIPPELHPTYMLSSQDLELEKDLLGLHNKHVGYTYLIDHHGRIRWAASAFAEPAESTALKTCTAILLDRALEAKKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH50</accession>
    <name>W3VH50_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH50"/>
    <dbReference type="HOGENOM" id="CLU_891972_0_0_1"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="266" mass="30238" checksum="3C9F7A8D7766097D" modified="2014-03-19" version="1">MGSKAASELASVPSEDLDAYIAELIVKKARTKQAHADERGVASYLEPGDTEAARVPNTNKRFLARVIRNVEGHNSALRRQQQRSEHRSASSSRAESAGSSKMRGWSDDERNTEEKARYGRSDVHSERSGEGMSSKMDKHFEEACSDSESRQSQRRSGAEDDKHSSSRKRRHDTERSPERDGRRSSSHRSHRSSRSERSERSERSRSGHSRPHEGASDDERRHRKRSHTIRRSSDRKSEHKSRPRKRSASPPSAPPPPKVREWDLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH62</accession>
    <name>W3VH62_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH62"/>
    <dbReference type="HOGENOM" id="CLU_095424_3_0_1"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000020">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="235" mass="24884" checksum="A0481AF8A0E09664" modified="2014-03-19" version="1">MILTGSSSLLRRTAAAAARAPTSQAPASLAIAPTSVAASSTILPAFAFGGSIQTRNSTKRGGGSTKNNRNSPGKRLGYKKQTGQLVYPGQIIYRQRGTSWHPGLNTAIGKDHTIFATAPGYVHFYYSEPTPSSSAQTAPASSPSGVKLPIKKLSPITFNATALVSTPHPSSKKQRRRYIAVSADPETTFPLPAGTPRERRFNRVDLNSLQSQIDQLKIHQQAADNLDSSSAPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHG8</accession>
    <name>W3VHG8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHG8"/>
    <dbReference type="HOGENOM" id="CLU_103849_0_1_1"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20508" checksum="5A12613B06993147" modified="2014-03-19" version="1">MSLVPPDPSQNFAFILRQPDISSSRNDAARQSQGTVHHRLEPVPLLNTNVDGKIKVQYALTQVKGVGRRYANIVCKKADIDLGKRAGELNSDELERIVTILQNPAEFKIPAWFLNRQRDIVDGKSSQLLSNNIDSKLRDDLERLKKIKAHRGIRHYLGLRVRGQHTKTTGRRGRTVANKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHR2</accession>
    <name>W3VHR2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCCH zinc finger and SMR domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHR2"/>
    <dbReference type="HOGENOM" id="CLU_014934_0_0_1"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053242">
        <property type="entry name" value="PAM2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651:SF1">
        <property type="entry name" value="SMALL MUTS RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833078" description="CCCH zinc finger and SMR domain containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="5">
        <location>
            <begin position="801"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="882" mass="91158" checksum="2521B3A39C10A918" modified="2014-03-19" version="1">MRERIALSAALCAFLVRLPGGSGVGSELVLPSPPHRPHPSSSIFISTGTGSAALLDIASPPTPTPTPPSSAPLILLSPSPPLSRMLDDSPRYARSFLDSILTPKNGTAPTTPTHPQSYSSNSTTATANTASSSASSSSGVAPLLTPAFKPHKPSSLSSSASASASEDGAAPDRDSSRPASPSPFGSPKLNIAAIEFKPRAATPTASSTAGPSATLTPTQPAPHLVRRPSSNSSSTNLALANKSHAGAGDDDDDEFSPFGSVKPTQQQPISFAGFTAFDPNAGWTSANHASNDAHQHWSSSDAHASLSARADSSEAKPDTSAPLTPFDMLYSILVTGTKAGSSEWSPEQVDEALVMHNYDIEKTLAAIWDNDGKPLGDGSQSLLAGGPSLPRAPVAPASTDSPRAFATPLPATAGVKAGVNVMSREALGLAATRGQRPGLSRSGSSQLTPRYEAAAGAGAGAGGAGARVCRYFLAGECRRSDCRFSHDLDNRAVCRYWLKGHCAHNPCNFLHDYDALNQLATGIVSGLNVSDSSLQRQATPEASDFMGAASGGDAKEDFPELGATGKDANSKSSYAATLGGGADASRNRWAATLQKKAPADAATRAQDDAQGVISIHSKAGPIRSQPAASIKPTGKASSSLSAAGRGSARIPLRPSALLPTLLTGSSASETYLAHRGDVLSLAEQRNKLLARASEAYRKGDVASASKYSKEASTLNQQYESESRTAAHAIVKERLGELRSRLNDPNLSGSNSAQSTEAGARSLRGKVVGNGLGVCLGVLRPGALQGSITASLSMDERTECLLDLHGLHAKEAVELTEEFLLGLEAEGIQGLAYLAIGKAKHSSKETDKRRVKVGGFVRQFLSSYAYPFAESDGVLVVDHLSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHV4</accession>
    <name>W3VHV4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHV4"/>
    <dbReference type="HOGENOM" id="CLU_406081_0_0_1"/>
    <dbReference type="OrthoDB" id="3355217at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="680" mass="72967" checksum="BB576636CA37EBE7" modified="2014-03-19" version="1">MSNYSYESVSPRSQAFNESIFSSPNSFCTESERSVSTHSSYSDDEEPVIRIIAPHSTRPMHGSHNINQEHNALGFSDLGYLNDALKLDPYSRASSDDTALDELIDLYQTNLAATVRGPLHPAARAAKVDSIGEDDDEVEVVDEQPRYTRAEKGKSVESVESEERYSSSPQSSSETSSLSGGACPLPSSGLTRDDIVFRVSTLTKDPPSLAAAQSTLAQKFPSLAEPPARMFGEDGSPLPPTKKEEISAAERKARQDALKVELKGSKVHSLVKAVIVLESRSTVWKKVSSLPKRSSGATPLPLLPELPNPWDLEITHEGLDISTIQTKTRKFLELPRSNTCGACRKCSGSGNETCRTCRGEAGNECFWCSGSGMQKGRRRCGRCQGQGKLSCMACEGKKASTCRSCDGAGCGEYTAFVEVKMRRIEVPAVSVADLLGSSQAAAATARPDIIKAAAVDMLWELVKMLATKATVKAKRPYLPVSAVCTWEKSVSYLAQVTALQAAKFKAGSKQPFRPEGLTRSVPTKTRYFSLPTDPALSIAELTLDQFVKQNIPEKHVVEVGPATGVHNVSRRLSCMLLGEVSAPSTPQLSSTSGSPKSSTDYFGDVAGAAGAVVSVPVTPVGGSPVSSPVIRPSSVRPMSPMRAPPAHFNSDELRIKMLRHSSSLSRSNFSRPLTAPGIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHV7</accession>
    <name>W3VHV7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHV7"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="93"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="492" mass="52759" checksum="5281D521FF752255" modified="2014-03-19" version="1">MPGNAATQPLGSTTTSTSDSASQDIAPTPAPDTAVATPMYNEKSAHPDDDTDIEATASQAAMSLKTEHDLGDAVAKAQAGDANISFPEGGFKAWLCVFGGWWCTFITFGYLNAYGIFQDYYQQTTLSHKSPSQISWIGAFQYFLMFAPAIFAGRLFDLGFFRPLFATGCALLVFSQMMVSLCTDYYQLFLAQGVGLGLGFGLVFNLAINCPAHYFNRRRGVALGVVASGSSTGGIIFPIMVRKLIPQIGYGWTMRIVGFFALFAVTIAWFSLSTRLPPSIDVHDKSKGGWKQIQWTDFSAFRNPAYTFFVIGASSIMFGLYMPFSYMDVWTSSHNIPANGYFLPILNAASSFGRVLPGLVADRVGRINTVLPHLAVSGILIFIFPLCTNLGGLITFAILYGFTSGCYVSLIPACSSQLGSTATVGARNGMMFFLMSFGGLFGLPIAGAILGDVENADWWATAAYSGAMVVLGTISIAAAKWYAVGGRIGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI48</accession>
    <name>W3VI48_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI48"/>
    <dbReference type="HOGENOM" id="CLU_398045_0_0_1"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="347"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="702" mass="76237" checksum="362137126A0601EF" modified="2014-03-19" version="1">MVRTPSIGSGDKDKEKANATLSSAFASMMAVGAPHHSTRNPFAIGQLKIADSTDSHRSRSDRSAASSHHDDERSQKKSKRLSAFGRSGRSISPFRFSSRKRSSSANRLKINPDDDTGSESGPRSERDHDSDNDSVISSSSGITPRNSAFYNPYDDDDPDAAAPHSHRRPHPASPNAPAVPLPKSSSSTSLASSTHDDPHGAEADVESDDDASDASDLDNKLSSADPQDDDDEDDQDDDEMDSIVLDNTLYNAGCLTKHEHWNGESKSEDGHHHFETYEDEDLERDDEHITAPNVVLSEDQVSTFLLRRGSKMLSLATSRPRFERNRCTITISHGDADAAAKASKRPKRYVVASDGSEESSYAVEWTIGTVLRDGDEMLVVSVMETDTKLDALDPKHEEVSARMEHQRIRQAMASVLAKQATHLLERTRLEVRISCQAIHAKNPRHMLLDLIDFYEPTMVVVGSRGLGSLRGILLGSTSHYLVQKSSAPVMVARKRLKLPALPRGKGDVVESVRARHMRLDQASIEKLSNVGEDDKNDTAADADADEAAASEDVSPDNETPDAKGVEQASTDAQTRDPAPARASTPPRRTSGSDDGSSSVAKAGGEGSPKLQRKGSKAGPTVISNTSLEREAETRKQIQQRKEEAAKLHEGDKKRHVFAHSSDHLKTSKSSSRPGSEDDTDPTDDEPKSAQLQHKDAAAHAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI79</accession>
    <name>W3VI79_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI79"/>
    <dbReference type="HOGENOM" id="CLU_016434_0_0_1"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="111"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="628" mass="67927" checksum="6894BB0376575BA1" modified="2014-03-19" version="1">MSEASGSASPSGDAGARGIRPKRAVRPTAKALLAREQSPDGWEHGGSKRSQPSRPIRTSSGARPQIKLKMKASGGGTAAGVGQGPKTQPYMQGYDRELDSEDDETGEGLAFEEQLIFRMPEGPECDKLRESIQKRQLGDDVWFKFKDSRRAVVHVGDSLFSAKLVDLPTITESHKTLDNRQFFKVADIAQMLVVEGKIADESQASSSGAGKGFNIEDFVYPHGITPPMQWARKRRFRKRAARRAIETVEKEVERLLKADKKAEEVEYEMIDAADEGGSDEDDAHPRGQSRRGVSSPGGSQAETPMPDGSDAGSQDEDGDDGDEDEDGQGERRRGHGEGGGVGGYDDAELDDEDDVDEDLAAELDAALEEEDDDDDDGESTRGAGSEAQSRASDQEDLWDDDDDDDADDGGDEDDDEEDENDEEKEQRVREAQLEAECRELETLLRRKQSDVDGTMNLIIKNRHQQALRKLTTERDMKRNQLAEIKQSRKERKEANLAAAAAEEAAHEAAASSNGAATEATGQHRQDGDEHHSPERQHEDGQRQQPVTASSGQLSAPIAAKDSQGSAPNGGMPPPALPASRNRPQSSASAAQPAGGSAPDPSSISNDDGDGGGDGDLWDDEDEEEDNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIH0</accession>
    <name>W3VIH0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003918_2_0_1"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="974"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1039"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="95"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="923"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="790"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="809"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1315" mass="144100" checksum="8D8741AD5F8A457B" modified="2014-03-19" version="1">MTNTTESASASAHPSPSSTADAAAPHIAVSSASPPVPSATDANQAEKQHSPDAISDNADRAKRSTLARHWKPFARRVGLDPLPSYVAWVGLCLTWPKLKPVIRSALLAWICLLIFLIAPSERALGNASFLVLVACAIQPAEVPLAAVVEREFFTLLFVCIAWAWSNIGIAIAHAARTTKLSQTQTSIQRVLAGDYIEARSSIVCAVFLSIGSAVVLYIKVRFGPSPFLFATVLSCILMNICLTYAPLYPYVFYSLGQSVVVPLAVKAAVNIILSVIFFPKSVNSQFVERLIAVLDPIAAACGDQVKLLRTSPLDTAAPADKDAKEGFDFDFVARKLAAAEGGLMPLSLSSRLLTREVSFGLANGDDLREFERLTRSLVAPADGWAYYYSSIKADIQSAHFPKTPVPSRLATPAITPAITPRTSLDHARNTSDSGHHATAHHVQLHPPSRPHSSGPAPAQHLSDTPHALLPASGTSTPHRESPLHAQLFPHDATTDSAGASATAFRQLDEHPSVQPGNELSSSRFRKMARSIASASRSSSPRRWMHHGHNSPADARDHTPWHHHHHAWERSSHMLHNFVHRRDPAPVAIWESIRFGNLETYLHTAAANHVTEMFARLIRETSCELLATDAGAIRHITAWLAHLNSHRYAFLRDRLMLSASQRAEKGRQQAESTRRVIASVETALSDFRTSKRLAVLEPYKAALRAHDASGATDDAAAELDLRTGPGEIGKIHHRYLYQAWLHQFHTINFTERLLTLLRDVEHVQSERTAASLWFPHWPRIFSADVWRNASGDAHDDDEPSTDPEHIPDISSDTPLASRQRSRSTNTAVDEHVPPKAAHAHAHFGGTESDTATAEPIVDLGSTRRRDPDALDPEGLLQVVGHTIYMWVRRPFRGNALFGIKAAVLIALVSLPAYIKSSAPWCYSNRAIWAIFMAQLTLARFRGETAFALLSRILATVIGAVWALVIWYISTGSGRGNAYGLGATCAVAFPLLFLYRIYYPGPPITPIIASVTTVLIVGYSWKDVTNPTPGSPGYGWSTAWRRLVAVIVGVSAAYIFSYLPPSSTLREYQRLSHAATIAELGKIYCAVVGIASHGHHDHASRRLEGESVAEVPSSEVVRKRIIGVRAKLRRLSMISVNVSYEFSLRGRWPSSRYAALFSVQMEISKLLSHCIAVLERLGPAYSIALLRRTRFLDPRFLGDVLSVISMCSTALKTAEPLPQVTPCPLVDRFMDTPHGFNAYLPDDVHTATDPLLAELPTKITLQTLEDAEYMTFAVGVATLFGLVVRIDRLCVAVKQLVGESYAVPVDVHRMLSTRKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIJ8</accession>
    <name>W3VIJ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIJ8"/>
    <dbReference type="HOGENOM" id="CLU_020178_2_1_1"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="74"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="478" mass="52748" checksum="3A2AB672AE257E20" modified="2014-03-19" version="1">MASEQRLASTSSTEGSSAVHGAHVSPQTAKEMQAETEQAPTPARQPPQLGQETFWSPRVRAQRAAYLKAIGSTTLIICIFVWAIMSMYWGSVWKEIDLSPNLDGWIINRDSGEIGSAVQEALLAANEGAKPHSTWTVIDPNRFPTQEEVDYQVTNTLATWIVVTVEENATAKLEQARANGDASWDPRSVVSLTYATSRNFQALPSVVLAPATATLNKALAQLSSQLAKQYLSSIATNQTAINNLANAPQTIANPIIAVNRDLRPYDVPVAIAVLVVGLIYLCILAFNATMANFGGRQGLQPFLRYRSLVAMRIIAPLVCYFFMSLMISLLNIPFNVPFGRTFSYGAGFMTWWAATFVGMCVLGLVTECAISLVGPRFIGFALVFWIIINVSVANLPIELSPSFYQYGYSMPFYNIRQIYIKIIFDVGQRVEMLKYFGILWAWLAVILITFPVWIHLEQRSAQKARQAQQKGPKNAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIU7</accession>
    <name>W3VIU7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIU7"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="178"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="336"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="54369" checksum="69833BFBC2D5FF01" modified="2014-03-19" version="1">MVDGRPERAALLDRRVSAKQRRSSDLPPRLEAEARRLAGQRERESVGWHRRHSELGHGCAGKESALEAGHLAETRPTWGAVPTGNSGLISHATSAFSPPLQSGREGSVPSSPARTPTPIYTLSPTLALHSHPLLFASTSTRPPHRSYTAMSAPTTMKAVVIQGPEKVAVVERPIPTPGPGEVVVKVSLAALCGSDLHIYRGHQPVPHYDFVLGHEFVGSVHTIGEGIKNWKQGDKVVSPFTVSCGDCFFCNRGQTGRCTQSRVFGSVPLDGAQAEYVLVPLADTTLYPIPADVPDEIMLLTADIFPTGYFVANNAYTMLNDAERKDSVAVVIGCGPVGLCAVTAACSFFKTVYAIDSVPERLAEAKKHGAIPLHLTNDDCVQVLKDATEGRGADVALEVVGAEDALKLAVKIVRNFGVVSSCGIHTHAVTLEGLDLYNKNLRFQFGRCPVRAVFDPAVKLLAKHHDLFGSFIQHTRPIEDAPEYYKLFNDRKVLKTVFKMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIY5</accession>
    <name>W3VIY5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PaG_04251</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIY5"/>
    <dbReference type="HOGENOM" id="CLU_006447_0_0_1"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000915">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="16"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="363"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="527"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="751"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="966"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="537"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="981"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ETS61504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1005" mass="107709" checksum="EDD042ADB355C154" modified="2014-03-19" version="1">MSKGTPARDESRIGDFVVENEIGKGSFAVVHKGYRLQPREPVAIKIVTRKKLTPKLLENLEGEIAILKAIHHPNIVELKECLKTEHQIFLVMAFCPSGDLSQYIKKRFDIYDRAGIPRPGALTRAPPTYPHPADGGLNETIVRSILTQLAAALEFMRGRDIVHRDIKPQNLLLQPPDAAFLALGNPAEIPQVKVADFGFARHLSVNTLAETLCGSPLYMAPEILRFEKYDAKADLWSVGAVLFEMTVGKPPFKAANHVELLKRIERGEDRIKFPDERSAGSLAREAARRQELGEAPLPPPHPVSDDVKTLIRQLLRQRPVGRMSFDDFFNSPVIRDFKAFIRPHAQAEAVERYEDLQRSDRSIILPSSSDIQQTSSTSAGERPQAASSPATPSSPSPRPRAEPKPLQDETPSTRRADSPQSANAPTATLNRTPSEASRPVRTIPRAFSAKYVTGEPDRRLDDVDRRDPPNMARTPSSPGLPDKLLTSDGREAHNQPAASAEGEDSFLGKEYVMIEKRNVEVNALADELAASPQTRMSLASRRPSRLSRLSSGALPTPSDISPPTSAAVASSSKPIRIAGNVSSSPTAGAFALPPGARPSSVPRRTSLSSSGSPSTRNAGQVITAGDAAASTQTSRRDGPSSSSPREDVSVLGQKLAGMGLPGASGSGPSSALAKAISMASLRLFGVPSGVSLRDAAALVRTRAQRRGFLRSSTETYDEAEVGLLSTLEDLGQKAFVLSEFADSKLAHHFPDGPHQLSQDLDASTATGVSPGRASAQGSARRVGSVSSSSSSALDPLAAEAAAAEALILYVRSLAFLQRAIGLTRKHVESRSRPGVAAVTSAELNEVVQWLRARFNEVYDKADFARSRCNELPESAQQVDKLIFDKAVEVARAAATDELENNREGSGWDPAHCLLAYETASSMLSSLLDPGEDALSLSEGSILMIDKYVKSINKRLVMLQEQFGAGAAGSGPAGVSPSGVDVEPRAGESRSRIDSPLSNASPAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ69</accession>
    <name>W3VJ69_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ69"/>
    <dbReference type="HOGENOM" id="CLU_322648_0_0_1"/>
    <dbReference type="OrthoDB" id="2554955at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="913" mass="96574" checksum="AB561F71C85AAF96" modified="2014-03-19" version="1">MLPAAGADGRGSYRSQRPVSDKEELARAALRSLADPSTAPPAPLPPPGNDAAAAPPAFPATRLPPPLPSQSLATQQASSSATSSALSQPDPAFRSSHDDYRRPPRSQYSDHGVPLPSASHHMLRHASLGDELIQRNPSSSSSPSSFFNDQQISASPDSSPRLEAAPIQMPRHTHLRHSIPASTQPSASAHLHEVALRRASIAMGVDIEQVRDIVHHAMDAPHAREPHFVRQVLDAYRLESDRASQPLVVRESWQAEPPRSNARNHVAYPSRYADPGPASRSAYPAYHDLARGDSVASGSASASMMPISEHRPESPSPFAYDAHPRSSQPSSDMAAPAASYSVHRPSHAHLDEASRHHRAFEDERFTTHRSRYPAYPHHPPPLPLPQTRAPERRVRSIDDYLDAPPQLYPRRHQRRGSMADYNGRTAVLTAVLTSEYDDERYRDRLARPNVRHSFHPYASPSSRYLGASADAIGISPQLSPTMGDAPRPYPIHDHRSPLLRSPAGESSTSVAGSVAALTPSPLLGVPVGTPDDRKRSLDGHADAPTSLRSASEDTAAESTRAGVARLQIDDSGSKPLLKSSSARTSRSSLASHSSAERQVPGTDLSHSQIMQKLQNKVKGRLAAKKKAAAESAAAFRPGGHKAAKPKRDAKPSGAKQDVSAEDTVKAEASKSDKVSRAGSTKRTASSISTSDRASSPQPSRPSVESSSAATADTSATPSGNGMPAPKVRRTSASSQQKPSTPQPPRQPIAAQLSPRPASTKPEWLPDKDQDKTPPASIEEALQALDSKTASKSPAPKSPASKSPAPTSASPPGKNLSPPTSISAALLSPTDSPTPTEAAAMHARRMSRSPLPPGADGAATVETSSGQALPGELPGAGQMNASSATKQQTSKAGIDSLIQSAQANDPTETNSAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJF6</accession>
    <name>W3VJF6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eisosome component PIL1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252201_0_0_1"/>
    <dbReference type="OrthoDB" id="3358861at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000138">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="842"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1435" mass="147965" checksum="E4ADCBFF8A87670B" modified="2014-03-19" version="1">MSMAPQAIHSNLSRPHPTDSRLLQNLIKGEKSYIDNLAAASHSGYAAASALAAWGTSEAPDISKASQTLAEILASVADAQRTHVQALEGYRSALKDVLDREHSIRSVVRDRDILVGRLIKASKKKVSKKDSGLSQDEKMEKVNAAQRELHACEQVLASEEAALVGVKRRTFKEALTMRMKTMGDAGSAMVDAAKEAILLLDEFDTHGPLLQATGGGQYESMYADDGVETGAYDQQALDSGYYAGQQSHSAGVASPIHADNYAAQGSPGPANGANLIRDEQGRFHKDLHGRNIQHFDGASVTPSQSASQVIDHDRQQVPLGQRYTSHFEDVEEQEGIPSDTDSEEDYRRAFIEPRMRMPAPHELGVAADTRDSFIPEGASAAAPPPPPRKDDGANQVPMPPVPSAPVFNVNQARGYDPNINADQASYQQQQAAYSPPRYSMSRRSGDSEGGYGHQRKSSNSLIGKMSRLFKTDIRNGTAAGNERPGWDTRTSGNVDDGERRRSGLLRRSEPDSSDDEPDTREVFRNVNQPRPGLATGGGSDVGGKSKLMRSSSAARILPGPKSNRAHDAEQAEIDRIRASVVGGGIGSAPPKQSLASVADSIRSNTTGTKKKKKKRPVAGSEIGTAPTRPSASYTISGDLSSLHGSTVADAARPGLSRSSTMKSTSSKKKNRASIASTGLVGGNIFNPNAGKFGADSWIKKPASQMTAYEAVAMAGVVPKESKPKEAKPASTTSAAPTTLAAPPAAPAASSRPASIMSSASKNPPLKSALKTPTLSRANSSSSNKALTTSPTKKSAAAPASPAPVKSALRNDITQSIRAEPLPQPKMEPIPKAPAPVTSAPLPETVAPQAPAATPAPVAAPQAVAAAAPQEKAPEAVAAPAAAAPAPVAPAQEQASPEAPQSVLSIEEDKGFDGTGRLDLSGDNAGASAVAASAPNAAQQNKAQMPKLDMPSTEPFSISFDGVAKAGGPRRGSAVTTGSAAEDGVVTPGAEQTYRAFIQEHGQSPSVERSGEATPIGTPAQDGVTRLTDRKVKLEPSRVYGAGAPEVSDTSSEEGSAVQVAADGRHGEGGAKKAAQVQESAALADPEHKPDPSLQSLTVPESKAPIKPLDTSALTVPTEGQGETDSTVSRRKSVRMAPDVKLPPDTPTEDSHATPRGNEHGGQDPMAVRGSQLSSRIAPPPAAPAKPAKEAGPVDLAGGRQHSGWTSRVRETVDSSDEEDADGDGYSSARKAFGSATRGWGEAMGTAKPKKKAGDAASVRSKASVTSKKKAVAAEASAPTTQASIGYVPTAPGSISSTLYTAKAPGSSVGASAAAVPSSSSLYTAKAPGSSVGASPAAVPSASMYSVTAPASIVSGSASQPAATASAPAQAPAPLTASNLSALDTKDRPVMPPVPQAPPVAGQSNMTVPTAPPPAIAGNASSTGGKGFFRRFKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJN1</accession>
    <name>W3VJN1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJN1"/>
    <dbReference type="HOGENOM" id="CLU_000288_59_8_1"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14069">
        <property type="entry name" value="STKc_Chk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034670">
        <property type="entry name" value="Chk1_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="654" mass="71438" checksum="757776D8B470194A" modified="2014-03-19" version="1">MPIPTSSTGQSYPPVLDYRLVQLIGGGGFSKVFRAVNPNSKSNPVAAIKVISYAPNRSNKYPIDRRALQKEVQVHSILKHPNVLEFLGAVERGVDKNGNAGKEKGILMGESIATTQESIEARDKERERMRSTPSMEENYVPGLYMVLELGAGGDLFDKIAPDYGVEEDLAHFYFQQLLSGLEYIHSQGVTHRDIKPENMLLDAEGNLKIADFGLCSVYKYKGKERELTGACGSLPYIAPEMNGKPYRGEPVDVWSSGVVLFAMLVGSTPWDEPTSRSPEYNAYRSGALFEYDPWTKIPADALSLLKKMMHPHPERRITFEGIRRHRWFRRQNELMTNKGKCNDPVNLAEKLLQGLAVSGDINLEVAGGAAAAAAARRLELHTDGQRAQVPENVSLTQPEAIQAGSFELGAGGSSARGWRDGAGGLALPSSTAMPSIAAGSDDMSRRLAMSQHITTRRQEFSSSATGSEVGLPGASQFTQALNHFTQFEALTNMVGAGSSHRFSPHLTRFFSSATPSQMVALVSDVLDSLAIQNATNAIGEQEELEEAYNFIVDGGEPHTSAEAASTTGKRFAIGTKGARIRLATMDKRKCPLRGEVWVENLMASDSGCDVDPVSDDTVKTLVVMKKGKGDPLEWRRLFRELCRRPEIQATIIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJT4</accession>
    <name>W3VJT4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJT4"/>
    <dbReference type="HOGENOM" id="CLU_343285_0_0_1"/>
    <dbReference type="OrthoDB" id="2100085at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041063">
        <property type="entry name" value="Glyco_H_20C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF8">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18088">
        <property type="entry name" value="Glyco_H_20C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="6">
        <location>
            <begin position="225"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside Hydrolase 20C C-terminal" evidence="7">
        <location>
            <begin position="572"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="832"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="917" mass="101569" checksum="4FFF31A2D5EF7333" modified="2014-03-19" version="1">MTDTVRDASMGPDPDVEGVQSNTVPLAQLPRVRICISRRSLPTSIGAGIEELAKHHIRPDVILLHDDEHPISAGGLSDNNSSSSVNPSVWNWNVHFCEHAAASDDPSQSQIGPLTWRCSTSSATFAPLHDHAQRSGALPVDEAFVIQVGFHVSAPHLAFRALGHVLGVAKDCLTLGNSDTDGTRLHPSLFAASSGSQTGRGYFLCPDVANERLNIAQTADYETIGTMIDCSRNGVLNVRSTKYLLRILALLGYNMLQLYTEDTYEIEGEPFFGYMRGGYSQAELKAIDDYAAKFGIELIPCIQTLGHLGQMLQWPRYLGMRDTAEVLLPEWPETYIMLEKMIKAATAPFRSKRIHLGMDETHGLGHGRYYSIYGHQNNKPGSQIFVEHLQKVNTICQSLGLEPMIWSDMLFCLSARNNSLVGYYDSAQPLDVKQQGIPQDVDLVYWDYYHTSSTSYETRIKNHEELRGASPWLAAGSWTWSRFWTALPFTFQTIQANLTAAKNSPGVRHVFLTIWGDEGNEVDLWSSLPAWCYYADHAYSTTFAAPNAQAAQGLDVSLVKSKFDAIVGGCWDDFVRASAIDDTTKDGVAVAADDKIHFAPNTSKWMLWGDPVHSFAEPTLVASGFDAEQHFASLASTLSDRLEGVTLEEPLRHRDTLVVRPQSESGSKSSGAGGLLGAAASLLGVGGFGAGGRPTETVRVLSDHPMNARLELARLVARTLSLKANLRQRLHQAYASRNWPQLRHLHRRTGRCFESATRLWQYHRQVWMSMYKPHGWETLELRYGGLVSRLDTLHRRVGAFLDHVLDRPHLDEDAAANGDSLQACAARADVFLPSPTRSGDSQATSHRSSLDDEQTDPRAGSADDDESMHSGRANPRTKWGWHEPVTSLPELEKPLHLVYGSPEQLLDYHRVSRPTYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJW0</accession>
    <name>W3VJW0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJW0"/>
    <dbReference type="HOGENOM" id="CLU_525998_0_0_1"/>
    <dbReference type="OrthoDB" id="3356769at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58696" checksum="7DB24C2863F11D88" modified="2014-03-19" version="1">MTSTVGGGHEAIDIDVEALAGELSRSSIHDPVGHLLVRLDDAQGYDRLPQPTLPPEVLERVVRHIQPDVLVGDPVAYITLVRLSCVSRLMRHWALEALYSIIILPRHVREFRKWYSRSVKSQPAFQFAGYSRALFSGLDDVSRLTSFSAGWDHELLRLLHYCGPTLTHLSLWRSESMALLRDPGQVREGYRFGTSQPVQVWGDKEADAEVEAVDDEDDGFVAPPEAAHADDLFSKEELDDMPGWLQAEIRLQGTRAVTIRHKAHLTPTRRITRRQQGCQPTHLSIMMSLPLLEHEDPKVFPRMLIWHRVQELDVHISTPGHTPRILRLLASLRESPIRRLRISTSFSSLCMMTPPFPPSKREQQAREKGEDLGTTDHSGAFFGETPYGRIKPPLNLCDALTSILRDEVLRGVLVDELQGKPHTAVAHLEHLMLRCCLDGPNRRWSSKPDCVEGADPSTPASAFDTQARSSSQPAWAAGRASDFRLTITRGNQALWAKLKDRLWDFRQRAEGLSEGSWEMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJX3</accession>
    <name>W3VJX3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import receptor subunit tom22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04994</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJX3"/>
    <dbReference type="HOGENOM" id="CLU_094333_0_0_1"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="137"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19058" checksum="92B797FD50D36ACD" modified="2014-03-19" version="1">MVRLEEVPDEEILRQQRASTAAAAAADDDDWEEEDDSDAESDFSDDSEVSERGLALKEETVWERISALRDIIPPSTRRSIASTFNTTTSYAFTGGLLLGKLGWVVTTSALLVGLPFALAVEDESRIVAQEKEMMAQQQGAQHMLAPAGAPGAPAQGQQAAQYQPQAQAPQGLRPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJY4</accession>
    <name>W3VJY4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJY4"/>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_1"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="277" mass="30104" checksum="870FA3FFC7DB904F" modified="2014-03-19" version="1">MSSPSSSSSSRRPLVGVSFKMYFDVPKTREYVDESISLLSSALPSLSKPTDIFVIPDFVTLSSVASQISSANSPLLLGAQDVHSQDFGAFTGEVSPKVLSQVGVKFVEIGHAERRRYFGETDEDVANKAAAIANNGMVPLICIGEVSRPRNLDELSIDDVDAVVEECWRQIRPALEGMPSKAEVVLAYEPVWAIGKAEPASPEYVVRITKALRRRYNKEYVGADKRTDESMRILYGGSAGPGLFAKISQGVDGLFLGRFAHKPQAFIDTVKEIAGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK22</accession>
    <name>W3VK22_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK22"/>
    <dbReference type="HOGENOM" id="CLU_608483_0_0_1"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="369" mass="40286" checksum="84FDE885629882A0" modified="2014-03-19" version="1">MSEIPLVGSFAASAHAGSPTKSLLTQQGEARDALLHIAMAQVLPDDSGLHAIPRSGLSKLENWAAKAAQEGADVVVFPEYFLSGATHELWSSVRGQQSQAEQGEQAWLDVILHVARKYNVDVVAGTVVELDAKAELPHRKDGGELYNTSYYVSRAGEVHRYTKQNLWHPERATLSNSHPGSHPDQHELATFVIETKRGTRVRAAMAICWDLAWYDRFNQMLTPPFSAASDLDRDGQVKGPDVIFAPTCWYASDGGSAALAWNPCAEARLLDSLTQARAVEIEALVVMCNIAGPIFSPDQIQSLTQQIKANPDTDLPLIGLGRSTIASPFLGIAAQTPDANEALLLQSIDLNVLLDARQVYRMRYDHALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK50</accession>
    <name>W3VK50_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK50"/>
    <dbReference type="HOGENOM" id="CLU_1993584_0_0_1"/>
    <dbReference type="OrthoDB" id="10523470at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="125" mass="13888" checksum="39D628D6EBD80003" modified="2014-03-19" version="1">MSYLFFLKKQVQPPAIDGQFASEPQSMCLLNLGDLPIVREASCFTPCIAFPALSNYIRVFLPAPVQFPTSMPIHVVLPRSHRSGPSIPTSTMLTLHQQRHIDDGLVFVRQSCMIDASYVPASRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKI9</accession>
    <name>W3VKI9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKI9"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_1"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016878">
        <property type="term" value="F:acid-thiol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050237">
        <property type="entry name" value="ATP-dep_AMP-bd_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43767:SF1">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="225"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="692"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="798" mass="85990" checksum="A28E79B33ED48AF1" modified="2014-03-19" version="1">MGRPASQVPRTFARAAGAARVDELAGRRAGFGGQSTNTTAHQPLLSFSHAGLAASQRRRRSRASGTSAGPPPLEAGRSTGNPLRRLAAARSPSRPSLVEASYSRSPGSAQPSHPHAERSCNSSSEASPIISTTSFCPLLAPFFQANVSLLEAFATMSSSAPPAKRSITQDFTGDKDTLVPFEKVDQLLTQPGSALETEVRLVNGRLTTVWKLLPNSVRDLWLFSASTYASRPFIVAEGESHTYAAVHKRAQLVATWLSRQLGVQKGDRVAIVGRNHVEFVIAFYAVHLLGGVPALVNAFLPGQAMYDCIRDVGCKAALFDVERFRRMRDSDTDLIKKLFGPAGPDCVDDFDCVPGAHSGLSGVAVFPRAVSGIVPENEREWTGGKAGDQVYDAHELDHQYADVAQRADAIPKIEILPEDMASVLYTSGTTGKPKGVAATHRQFLSAGPNAGYGVASAYVRRGLAPPVPQPDDEQASSILLIPLFHSTGIQSGLVPSTARGTKICLMPKYDVDAAARMIQEHKVQIAVGIGFMVRELVLSKHALPSLEAISHGGSSSAKEIPEEARAKKPAMLVGQGYGSTEVNGAASALASDDYRLRPTSAGRAPPTIDIRIVDPDTLVQVANGKVGEIWIRGPNTALGYWGKKKATEEAFTRDGYFRTGDLGRKEDDGFIYVMDRSKHIIIRGGENISGTEVETAIYSERRIIDCAAVPIPDDRFGETVGIVCVPRAEFQKQNRPTEEDVLKVARKLLPKHEVPDFIWIRDEPLERNANGKVDKAIVKEAARKRHAEQKAASAKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKJ8</accession>
    <name>W3VKJ8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000017">
        <property type="protein sequence ID" value="ETS61322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKJ8"/>
    <dbReference type="HOGENOM" id="CLU_048587_2_0_1"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="334" mass="36571" checksum="D257118D8A6143EF" modified="2014-03-19" version="1">MAVHGKYVTEKVTYPSHGETVAGILYRPKGIAKPPGVVLVGPYSYVKEQAPLQYATRLADEGYAALIFDPRTVGESTGAPRRLENPKMKNEDAVAGLDYLVSRGDIDPSKLFLVGICQGGPQCLDIASRDDRVAAVASVTGYFRDRETDIYMIGSGCVAWTPGADIATMRMPTAKQGEALLDARLKRAEEARALYEKTGEVVYQPLVDPKAADPDVGSLAGLPGPVSWTFYGPWTMKNFDNRYAVMSDLDHFSYTTVPGVAKLEKPALIIHGDNCMNAPSAKRHFDSIPTKSKKLIWDNEVSHFQHYEQPDCVDRNVGEIASWFQKVLDGASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL67</accession>
    <name>W3VL67_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL67"/>
    <dbReference type="HOGENOM" id="CLU_301315_0_0_1"/>
    <dbReference type="OrthoDB" id="2551385at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1007" mass="108504" checksum="D20F628734EDC5BE" modified="2014-03-19" version="1">MSTAMQPRALPTITVFTHPAARLIKTVPPLEPPKRINGHVPRDNIGVGRTASKDVVLTDVYGPLSILVVPDPLDPTIATLVISVTLSDPQLQGAARRFVLPFRSFQRDPVSGDIISQSKISGFDAADRTLYPGLGTGLKGLDGGSFWFFEDIGEDGAFDRYRWSKDGVANRAIWTVWLISTPAPVVHHVQALLQSYPAPLPSLPPWLRENNGYPWKDTFLALPSSSLATPSHSKDQEQPAQESAQPLESSDSSLAITTPSAKLDPAPDTPSSPTHEATAVPTIRSRRLRDGSSSMRIGDTPEVVLRNVNRLVTHSEYRNSLVAVDNRTGQIVSVLASHISLEADEPAAAYTASSSEPDAEVHDDHEAVTPLDELAPILPDKTPSQALGLHPALLTLSQDPVEEQVDEEERDFDTPKPSTIVHRPAALYRDPDAQRPPSRTASILAADTFAPPPLPPKPSSASRTRARADSRATADAPASRRTSTASAFFTAESDADAMSSYDSDAIEIDASSISHHNLPSSSISIRGHASHDVEKHRPELLRDANHPDSDGEYASDASGSTVGGPVVRMWRKARGKPKKKPGGAVQKAGLQSAHPTQRVKSRQASEVSHRTSKAETALESMSDDEADQQPQDRKATTDDSNPAWPEQDIMSPFKSAQPSSGVGQHLPRSALRTDEVRSIEDRVWREALDAGQLPIDAPYTHLAARGEAGFYPSSILSSPRSFDDGSAIELLSTEDKRRQVQRKKVELHKQKQRAERIKNMQGGTVLIEFLAGSSRIGASLIRSAGYTPTTSNDEGVHDADCNNTQLSAGDTASNMLSYVPLLPQHLLGFFGLGPRSSQTQAKQTPDLASPTLAGAYFSGLRMLSLGGLLTDASDWVTGFFGRSSVEAKPSTAEVEVAGDGSRAEEWEYAIPDFDPNSLASTPRPVYRRKRPVPSAMNGFNISAPRCSDDAKRGVEVLAPPSAAVKTVQAAEAAPTEKASYSILHIDSLGVGRRAFLRGHPEFEGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLJ5</accession>
    <name>W3VLJ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262316_0_0_1"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="2">
        <location>
            <begin position="299"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1411"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1485" mass="156949" checksum="3F1344BB59120897" modified="2014-03-19" version="1">MPRAIGRPPTPCVEDLLDHASDKSATACRSHRFPCLPRAERDRGKTLLCPASRLLLVTRLSWQSIDSRLLHPTALVLKAELTLTLIDCTNVRQHFDHSTSSKEHYQISAIKLGVAERSVEAERLSHLPKKPASLPSHSTGHCTAIRSDTQRPQETAAMFSHTRRSASWAWLCALLLLAWKVEAEVRVERPISSQLPTIARFGQPYTWSFAQNTFVDTNSTAPLRYNATGLPSWATFEPSNRSISGVPQGPPPGSSRVGTNVTLIANNPETGSTASTTYQLIAMTGSGPTVNKPLAPQLPNATTLGADSILPSGAQRLPLGWSFSLGFAGDSFTSDSHRVYLSAALADGSPLPEWMHLDQTVTLWGVAPTDVHTAGSFYDVVVTASDVAGYAGVNSSFQMVVSGAPLIQSAPFPIINATAGQEFSSQLPLEGIVDSAGAPVNVSQLRVSANTSAVGGWLSFDDTSRTFSGTAPFNLTQAEAVSLTVPVLLTNATDPNAAPVPASARFSVYPSPFSVSSLPDVQVTPGKMFQVELGTYFRETQTPPQLTLNPASASDWIHFDPMGMILSGNAPKKGAERVEVQLSLDSAHAGSDYRSVSTRSFAVNPIPSSTSPTPLPAPGRSTSGASSPTSSSTSTEGFASSVSGSETSSQGLSSKAKIAIAASLGGVGGLIMLILLMMCCRRHCAAEDRHFRGAHPDDYASDFEKSYEGRNLGDDERTLADDRSPRFGWASLGPAGKKAGKDKKDEESASPYLDPYAALAADGTPATQRSPFSDAMTLAPSDEGHGQNLSNGQPRQVITTMGNIAPRPSQPPSAFVPAPAFTITNPSPMAADKPRRSSVLNLFSRTPKASKSSRSIASFAAADANAYPAEADQRDMGAGQGRFESRPEMASPTSIGLGLEGMMGRDLSQMTTSKSLAARSSWESNLFYDDTMDRGVSTAAAPSTPERRRAVASRTEALSLDSPLEVPVRRNLISAPMRHRNAHINTSPAFNLNNSFESSPERDDDGPKDRLREPRQSDTPVASARSRGHAGPVASVDLDDAVVGYARKVSVETSGTIPPPQQVSIQQGQRNLSQHLENYMHQAQRGASIDTTRSGSAAHGANEDDPFEDAEDDPSNAAVMRDTAENTKRNSAASYVPNLAGAETAAVRYVDSRRSSMKPSVGHSTPTRTADSTGRAPGAGRTSEDSAHQPSLRAVRQSTGPVPASPVVPGSSKREGTAVTENPKTPTRNQRNSVAPDTGDTSATKGAAGGGHPWSAASSASRGGGIFQTPQSTATPSRTAHRATSSISHRRSDSSTRSGDAPPVGGSTPWSRIRSHNVTVRPGELIRVSALAGTAAPPMVGGAPGSPGKRSGRKLSYHPVLQDEKYFEYYNTWPEFLHWLRWDDRMQELSGTVPPKFGPTPLTLKLAILARPTGGAPPSPSPNSSPTKFGARSSQGHARSASSASNASYGAGGGATAEDEVAAIVMLDIQKLAPTTPGNRAFIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLR2</accession>
    <name>W3VLR2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_03121</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLR2"/>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_1"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="74"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="189"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="300"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS62494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="451" mass="48788" checksum="E56247D9769F32B1" modified="2014-03-19" version="1">MLRNALPALRRAAATGSHAPAVATAASSSSSSSLPSSSRTYGTTPDTAPEQYKMTKFSKFNWEDPMAMFESQLSEDEKAIAQTAHDFCQETLKPKVTEMYRNESWDPTILPSLGELGLLGATIDGYGCAGVNSVSYGLIAREVERVDSGYRSIMSVQSSLVMGPINQFGTEAQKEKYLPRLAKGELVGCFGLTEPNHGSDPSSMETTATDTGDGHIILNGSKTWISNSPHADVFVIWAKCKWDNKIRGFIVEKGTKGLSAPAIKNKLQLRASVTGSIFMEDVKVKRDESLLPHARPGLGSPFECLNSARYGISWGAMGALEACIEEARQYALDRSQFGRPIAGFQLIQQKLADASTEAALGLLCSLQLGRMKDQGAWSPEMVSLAKRNNCGKALQHSRSLLDIFGGNATSDEYHCGRHVQNLQTVNTYEGSHIIHTLILGKGITGLQAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLU5</accession>
    <name>W3VLU5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLU5"/>
    <dbReference type="HOGENOM" id="CLU_373833_0_0_1"/>
    <dbReference type="OrthoDB" id="2554393at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="743" mass="75506" checksum="E54C1B117EC90DF3" modified="2014-03-19" version="1">MSTTVVTVPVTVTASQSVVVVTSTIATTNAPYITGLPTSSSDPESSASAATDGANSSSGAGATSSSSPSSASSGSATPVGAIAGGVVGGVALIAFIIVLACFMRKRSKAKKTPSPFPDDDDEKGPSVIAGLPPNPSTTHLRPLSGTYNPSMVMTEASAMPLLGTDGSVHSSSHGPGGAFTADARSAHMQRPSTTSLAPSFIMGSSASYPHSHSSHPSQPWSGAVPPSGYDSPSAFAGGYPDVHRTAFYEPHLPPGVDPRALPASTIAAGSAAVAYHNAGASASTASPLAHGMDARALAAAPGMASLPMGAAPANYAAVSEAARLRSASQSGSHGPHGAELRSGAASMSDASSRRGSHGSTLAMHPAVAQLSEASPQFHADGGSPHRRPPAAGFPGYQSNLNTIPGSVAASEIASADHQSLYSGAQSHGGDATVPPRLPSIPASSPLILQDAAAVANAPRAASFGSTAARLTAEPATDTLRSNDASTGTYNSDGTYNTYTGAIKGQLRVVGSSDAHADGARGTTTIVEEESPVSGPRREMSSDSKAGEFWIEGREKSKLGAAGQRLGQHSSNNSTSSINKSGSRMIEMLDVDEQPHVPESVTGRAEPSPSTPSRPSFWKERTKSSQSIAKVFRSSPLLHANASPSERSPAPTSGARLSGVAAESSRSHSVPEHLPPLDLGRSVAISDHRASDSPKTEGDAEMWKDASKQKHGGAMRRWTRKKAGRSGSGTQGVDNEMDVDELFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLV2</accession>
    <name>W3VLV2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_03853</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLV2"/>
    <dbReference type="HOGENOM" id="CLU_1661559_0_0_1"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS61757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="157" mass="16980" checksum="B09FC19AA6FDC240" modified="2014-03-19" version="1">MATIQEVLDQVAALPTAPKPYVNPYAGHRALAEHEQELLGEYARLADTIRRVAALSTILSSSAAHADLLTQMRVLERKMGLVLTLYKASVWATVQEQAEMAEAEAMAAAGADAYGLDMHPDAYNGDGANPYYYNAGAAPEESADGDDTVVMRQPEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLY4</accession>
    <name>W3VLY4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLY4"/>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="4">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="34768" checksum="7E6B9BC6F6EC35DB" modified="2014-03-19" version="1">MVALEVLSSVEALPETKTLKRGIYVPVLTFFKGEHGAVLDLEAFEKHIVYVATSGVAGIVVLGSTGEAVSLTDDEKVTLVRSTRKAMNACGCSDMPLIAGAGGHSIVTARESLAAITNAGASHALVLPSSYYPNQLGAPAALEFYTAIADSSPIPILIYSYPGVCSGINLSSDVTRKLSQHPRIRGVKHTDHDIGKMARNCALPAAADDGAHFLVLGGASDYLVGALAVGAHGTITGMGNIAPRAVVELQHLFDQGRRREATELQHIISLAEWELGKGGVPMHKALVESFHGYGGLPRAPLQPSPKETIQHAVDAFHRLMQVEAELAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM28</accession>
    <name>W3VM28_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_02440</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM28"/>
    <dbReference type="HOGENOM" id="CLU_009673_2_1_1"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="13">
        <location>
            <begin position="36"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="14">
        <location>
            <begin position="262"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="15">
        <location>
            <begin position="493"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="614"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="722"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="635"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS62703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="884" mass="97520" checksum="36488C3ACBD3A2B3" modified="2014-03-19" version="1">MAPSVVPQSSAGGAALQASAEDQLTIEMLGAGQEVGRSCCVLKYKGKTIVCDTGVHPAFTGIAALPFIDELDWSTVDAILITHFHLDHAAALTYIMEKTNFRDGHGKVYMTHPTKAVYRFLMSDFVRISNAGNDDNLFDENEMLASWRQIEAVDFHQDVSIAGGLRFTSYHAGHVLGACMFLIEIAGLRILYTGDFSREEDRHLVQAEIPPVRPDVLICESTYGTQTHEPRLDKEHRFTSQIHHIIKRGGRVLLPVFVLGRAQELLLLLDEYWAAHPELHSVPIYYASALAKKCISVYQTYIHTMNDHIRTRFNRRDNPFVFKHISNLRSLEKFEDRGPCVMMASPGFMQSGVSRELLERWAPDKRNGLIVSGYSVEGTMARNILNEPDEIIGMNGIKIPRRMSVDYISFSAHVDFAQNSRFIDEIKAQHIVLVHGEQNNMSKLRAALQARFTARGSDVKIHTPRNCEPLTLQFRAQRTAKAIGTIAAKLPAQGDTVDGLLISKDFAYTILDPKDLTDFTGLSTSTIVQRQRVALAVSWDMVRWHLQGMYGRLQEGIDAEEGLRTLRIMGVVDVRQSARHELLVEWGSSIANDMVADSIVALLLGIDSAPSSVKMTMHSHDHSHHHGEDAKPAAEDADQEMDGAEEEEALTPPEGADIVPPHPFSEAALLAGSSAGAAKAASDETARHDAYQLAKMEHMAAFLEAHFGQVEELVIPELPDSADAEEVPAGPNAPIQAESVKENADEAVPVKTEDTSDAADASASAEPAEQAERNSAEQDEVQPSLPPIHIASLFDGESRPALRVFLDDTEAVVDVQNLVILASSESFRTRVQHLCTLALRSFTSLSDAFHLPQQMANPLFQGKHSQLAQIPEFGEERPAKMLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMM3</accession>
    <name>W3VMM3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMM3"/>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_1"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="290"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40853" checksum="13374CF43C86ED28" modified="2014-03-19" version="1">MGVVEKIKELEDEVARTQKNKATEYHLGQLRAKIAKLRHELLEPQKKSGKPGEGFDVMKSGDARVALIGFPSVGKSSFLSKVTDTKSEAAAYEFTTLTCQPGVLEYEGAKIQILDLPGIIEGASEGKGRGRQVVAVAKTADMIIIMLDATKPDTHRALLEKELEAVGIRLNKSKPDVVLRKKNAGGIVITKAMGLTLTKIDERMIRSILQGYKMHNVDVMLREDITVDEFIDVVLGNRNYVPCLYVYNKIDSISMEQMDKLARQPNSVVISVEADLNIDYLKDIMWDKLGMNRIYTKKRGERPDLSDPLVVRKGATIEHVCHQVHRALVDKFKYALVYGKSSKFPTSQKVGLNHIVAGDDVVSIFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMT6</accession>
    <name>W3VMT6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMT6"/>
    <dbReference type="HOGENOM" id="CLU_532309_0_0_1"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="57430" checksum="65EAB09E932CC123" modified="2014-03-19" version="1">MDTKRLQVPVIGLRRSGKSSVLNVVYNELHPDDTVFLESTTKPNFILSDSFLPIRIIDTPSRVLLGDVRLEKGIPLAPANAARVGPPPPVPARNAPLQSSNATASNAPAAAAAPELLLWTDVSAVVFVIDAQDDYYEALSKLQTVVLSAFAENQTIEFHVFVHKIDGYSNDYRQDTLSTIQGKVLDDLVDSSPSFVAQPWSYPEPIPPKETKTSKSKDRSRSKSKDVSFSRSPAAGNSSSGGGGGGYDASASEFSSFSGGHRSDVAPEPGQINLDQAVRLHCHATSIYDTSVFVAISKLQQSLAQKVKPEEVLEPEPHAASNGDEGAAAEGGKPTRPAAKSHSPRSLTLAESMEQVCDSICSSCHFENAFLFDLPTRTFIGTDSAPFDAASFDLVFDYAGFLAKFAGLYAGIQPEAPPGGSSAATPSGGAMAQLSTSPSSARRFLLGRMSKEPPASRDSGAGSKDSSATSAPVQRWASSVTRLQPDRSLCFWQINHRLALIAIIHSDVHAKQTGLIDYNITFFRRAVQGLYSLAQTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMU0</accession>
    <name>W3VMU0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMU0"/>
    <dbReference type="HOGENOM" id="CLU_025518_1_0_1"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="15"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="357"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="416" mass="46202" checksum="7A1FDCA840BBAD93" modified="2014-03-19" version="1">MKGLAKAMKRTPHLMTSKIGMAAKSSDAAFDSLNQRFTNLEKLSEKLLKDASTFRDAVKNMLLSGANFGRHFDTLFQPIGSEYDLEHRHPNAQHTIVNLSAYGQLMDELKETLTPEIELIESRVIAPTKDFQMVVKAIRKNITKRDHKLVDYDRHNNSYSKLRDKKDKSLKDEQNLFKVEQEYETAAADYEYYNNALKEELPRFFDMASRFMTPLFHSFYYMQLNVFYLTMERLQTFAQGKYDLTNNSIAVVEDTYMAQLTDAAERLENLTIRRGAMPTAKILAQNRASGGGLSPSGSRIGGLAAGAPSRSGSILSSHSNAAAAAPPAYSPTSAAAAGGVTKRPPPPPPIKPKPGATPRTYVVALYDYTATADGDLSFKAGDRIEVTERTQSTDDWWTGIVAGQKGVFPGNYVRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMV2</accession>
    <name>W3VMV2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMV2"/>
    <dbReference type="HOGENOM" id="CLU_338047_0_0_1"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="600"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="842" mass="91369" checksum="D64F416F35B20319" modified="2014-03-19" version="1">MKAPRSEEGMEWKGDGVVARPVGANEEASYDEKLGAGAAQGPDCFEQKQQQQQPPSALRSPTNTLFLVAAPRRAPTSVAAAQSTPPRSDKGYQAADGRRRADEAMAMPTLAVSAIYDPTQIVETRLDRLAVDPLWNRSPPLSGRWGSVRSTACRHFCEAAAAAPAAFVDMPTLSEPLDALAVISLMLHFAHQAATLARSSERAMLVKSGSVRLVAWRHRRIDSSSWDREIPRPPPPPPVSEGPAAQKGCASSKSHHRVFYPKFRADLDGPPSQAPRKSMTAAAASGRGPSSLLVPHPPEVGEVGSAAIESDQPSISSIAQLTHPRPTSICTGGPVFRTSRTAELVSLESHSFASSTRQGTGLGTIHRLITLAHHISGICILPSHCYILQTSFSNMQASGVFRAAAQCSRSATARRAPAMATARIQHSTYSASIWSRSASRSSSPALATAFYSSPLSRRRELLAGALRTLHQTNALAESRKSTPPSASQPVKSVPPTIKTASTELNKQSDTETAVTDAKPTKSITERAKELWATAKYLFKFYFNGVKQIWANRKAVQVVQQRVATGGSALTREESQLIRTHQADMRKLPLFLFILLILEEALPLVVIWAPSLLPSTCILPNQLTKIRMGDEVKRADAVKQLKESEAVKELIPVVKASYKALSLTPAHAAEDGDVLKQLSSEELAKVAKIFSLATWGGAGMVRRRLDAHMAYLREDDALMAIDTGAGAIPQHADALAKACGERGLRCSGIEHLDMFESLRTWLRYTTRHPSTRQISNASVALLPLQMYDASALSEVKSSLEAESARGLIDKTKDVLREVVEEEKKVIQRDERSKQESISKQHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN13</accession>
    <name>W3VN13_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN13"/>
    <dbReference type="HOGENOM" id="CLU_2134608_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="113" mass="12260" checksum="C68965DA3D9E8C3A" modified="2014-03-19" version="1">MHLTDQARSDYCCSQALRLAERAYRSAATQGRVNIAREEGVAAFDASAEWSSCSSLGVFASAVLRDAAAMQFEGSPPLLDTRSFLPTFPKQQVAPACLPKLPKRAEAKLKNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN27</accession>
    <name>W3VN27_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN27"/>
    <dbReference type="HOGENOM" id="CLU_439488_0_0_1"/>
    <dbReference type="OrthoDB" id="3367047at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="558" mass="59509" checksum="8E1D8F0EB8AD2B46" modified="2014-03-19" version="1">MNTGYGMPSRRRLRGPLHPRNRPPPSSFDEPASSPQSAPQTGFDAASMPPPSSTPSSKKREWTSTIGRGGLGSLPWEQMGPSSSGPSTSSAEFSFQSGMAMPQSTSTTSMASMASMPSSSSASSFASFRQQPTPMSASPSSFRTAADADESGYAARSTIFSRGNQSAQAALRETSQALHESTYATADEQPRKRRRGLAGTIVDTALNAALYTGAAALTAYSLWSSWGHAGDAEQQQHHPDAGPQADMGDVISQNERTNTFSGKESRMPPGGLEEPPPPYYEDHSTPSRQEAAPTTPQSNSVRTRKVFVSSQRNRRRPTFQGSKTHRQSTPRKALPDAFRASQTANSPGMSASGSQDLAPAQMEDDDDDDDDDDDDEMLSRFEAKMNALIAEGQAALNSTPVLQESDLRDIDTPSPSLGLGTHSRSSTPLFGQRSQLPGSPFASLQPDAGVARSSSHPDDLVPSGALPEPVKRTFGTSLRHSRSAFDFQFDNRAAADTGAGAARSPFVFGRAELNESATPSPAARQARRTDLGTPTSPYSRIPRSTSTLNARKSTPHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN60</accession>
    <name>W3VN60_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN60"/>
    <dbReference type="HOGENOM" id="CLU_069535_0_0_1"/>
    <dbReference type="OrthoDB" id="5295431at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11665">
        <property type="entry name" value="LamB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003814">
        <property type="entry name" value="PRK05406.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="266" mass="28790" checksum="E0F0E9E44E26FC17" modified="2014-03-19" version="1">MSARALPQKIEINSDMGEAFGRWQLGPDEELMKYIDVANVACGFHASDPVTLHKTVKLAKKYNVAVGAHPGFPDLAGFGRRRMELSEEEVADIITYQIGALKAFCDLEGVPLNHVKPHGALYFYLKNSRSHCEAAYKAIKPLGVPVYGLGGTLHEEVAKELDIAFVPELFVDIEYSKEGALIPPAQSKKITPQESAERARKVAETGHNYAQGGGEVNMPEFGHAGNGGKCKPFSICIHSDLPGAESTAAETRKTVDELNAKLFPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VND7</accession>
    <name>W3VND7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VND7"/>
    <dbReference type="HOGENOM" id="CLU_004471_6_3_1"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="449"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="662" mass="71668" checksum="E25CB666C678CC50" modified="2014-03-19" version="1">MSSQTDDDSVWQLVSAKESKLPGVHYTFLDANESASSHNDVETSKIPLLRLVQLLVGSRTSAKTVSQHALKLNIGRLRSAQLIVERYNANPGCSVARFRAAELLSSMGIASAAAAAAAKEPTQPARIHIAGLDSLLNSIDPVDGGLGDRHDPQAAYVSFDDLDACFAPGRLVTYPTSVGHASERTAARVYSCHFEERRSAFGSIERQFNLELETVVPLGSRLGLVTFTETFSGWTGDRRKRISELLVRPLLPGRDDEELESFELRGRRCLSLLPGANEAERYRFLAYEAGGFFAHADRTTSTASTAAVPSGAGSGGRIVVDGDMALALGHHPSQGSTEADHALLSAAGRYKRSGDKAEGLLVLDAMPDSLIRLVWPALSGFSLTAKRWGHVLVSSLSEIRFNRAAFDQLVLSPERKRLIHAVVNAHRQEQPGQAKRTARFRDIIASKSGGTVFLLHGAPGVGKTLTAEAVAEMLGRPVYYVTMGELGTAVENVEARLAQVLDLCAAWQAVVLIDEADVFLERRASGGGGDILRNALVCVVLRLIEYFSGILFLTTNRVASFDPALESRVTIALRYDALDAGAREQVWRNLLGNLEDSDVDLGQLDFGRLAKHELNGRQIKNTIRLALALAVDAQSPLDQALLDLTLQTTMMGRLEMEGGYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNF1</accession>
    <name>W3VNF1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNF1"/>
    <dbReference type="HOGENOM" id="CLU_045011_8_0_1"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32768" checksum="B4743837ECACAB8E" modified="2014-03-19" version="1">MGRFPAAAPIRVVLFDAFDTLVTPRAAPHLQYAAVAREHGLDVADSDVKAAFKQAFRITATEHPNYGLETDIASPDHWWALVIQRTFIPHLHPAVSEEQYAATIDSLSHRLVTRFGTSQAYRLFEDVVPTLDRLARMRARDDRPVTLMLATNSDSRILGVLKSFGLDRFLHLDVDGSASAVQSSAGPVLSYFEKCAKPDSRFFQAALQRAATHLGESVPPTNALYVGDQLHEDFWGATTAGLQAAWLQRSTGAESNQPHQQVDRARDDPHDLEHAHQRTITSLADVVDLVESSHTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNH1</accession>
    <name>W3VNH1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNH1"/>
    <dbReference type="HOGENOM" id="CLU_009665_9_2_1"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="21"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="460"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="82459" checksum="486AD8142DE3D495" modified="2014-03-19" version="1">MAHPAGANNGEAAASIKESHCDVLIIGAGPAGLMAANWLAVQGLGASVRIIDKRSDKIFTGQADGLQCRTLEILHSFGLGEDIWRQSNRMIEMRFWNPGADGQLQRTGSVPDTIPGISRWQQCVLHQGRIEKAFLDSIQRHSDGKLAVERAVLPESLSIDEHAVDDPDAYPVTVEVRKLSEEEATPTQMGKSVPNGLFRSSLAPDDTPSSVVGTGDRERIHAKYVIGCDGAHSWTRRQMGSKMEGDQTSFIWGVLDAVPITNFPDVRNRCAIHSVDSGSMMIIPREDGLVRFYIQVSELNRGVDRHSITPEMILATAKAIIAPYTLDIGEGDLDWWTAYVIGQRTADRFALHDRVFIAGDACHTHSPKAGQGMNTSMQDTYNLAWKVAAAVKGVSPRSVLATYEMERKQIAQDLITFDHRFSRLFSGKPAKDEADAAGISMAEFQDAFLKGNRFASGLSVDYQRSLLTVKPESSSKTTVDGGEVVAHAAVAAPADGVASDPSLSAEDAGETRIDVGKRFNTAQVVCHATALPYELADWILSDGRWRIVYFCGDVREPSCAREMQQLGDYLSSDLLPRFTPAEQDVDSVIEVLTVAATPRAECELADFHHALRPHTTKHHRKTADGRYNTSQDYHKVFVDDTTYHQGHGRAYEKYGVATQYGTLVLIRPDGYVSLLVRARDHTQLGAFFEKVLLPAASHKPHQHTRIKRTTPALMLTPQPKAQVPPREDGRSTLDLAHSLKNTQENAAPGAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNH6</accession>
    <name>W3VNH6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNH6"/>
    <dbReference type="HOGENOM" id="CLU_543996_0_0_1"/>
    <dbReference type="OrthoDB" id="2556464at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="51580" checksum="C56218809F09359D" modified="2014-03-19" version="1">MASVSANGMPSSNATSANATGQASPYVGTSPTVPATSLMVSNTSDTALTLVTLGPLSACVSIPRLDNTAAPVLSNSTVIAQHQLDAWLGKLPTTTRCTTLAWTLRPDYSDPLDALARFQDQIDQLFPVQNSTFAAKMLEAQPAGNASFFQPSSGAGLLLAPSSGPRMLPTTLPIWMGAVMAGVVLVHLVALLLHIGAEIAVLFPSFAAKSKPPLAQSLPMQNESTATLVEPKTTPEDGKIDPPGYTAPSVDQGVAGSVGDGQLPVARACRSAKRVFVPLLLLAALGMVGIAVVLNSKFAQGPVGVASSALVSTDTASTSASGVSVASSLAVATSSVRRAGHASNATSADSTALPTGTLSMTRLVRRQADFFPPAPAPSRSSSSESLAPTWTSTPSTRSSLVTPTPSSSAMFGSFSSPTSNFSLSTQSVTPVATTAPVASTTDVSNEARSLLVLERGSSMHRVWWIVMLDLVLWFIQRRRTRSQYALDKAHATLLPRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNL9</accession>
    <name>W3VNL9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SUC2-invertase (Sucrose hydrolyzing enzyme)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNL9"/>
    <dbReference type="HOGENOM" id="CLU_001528_3_3_1"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.560:FF:000010">
        <property type="entry name" value="Glycoside hydrolase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000002">
        <property type="entry name" value="Invertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF2">
        <property type="entry name" value="INVERTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834411" description="SUC2-invertase (Sucrose hydrolyzing enzyme)" evidence="6">
        <location>
            <begin position="21"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="82"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="414"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="66098" checksum="8EF55FCD791217C9" modified="2014-03-19" version="1">MKASIIGALGAVIAAACVSAVPSPVDPFDLGSASHALYPRMSAGQSGDGSNNDKSKCPSSNGTAVSGYQYAPYSEPVRPQIHFSPTVNFMNDPNGLVYSNGTWHLFYQYNPTQNVAGNQHWGHAISTDLYHWENLPIAIAPEKEGEGIFSGNAVIDFENTSGFFNESTPKDQRIVAFYTLNTATSQTQHVAYSSDGVTFTKYAPAVVERNQTQFRDPKVFWDDKSSRWIMALALSQEFGIVFYASSNMKDWSEVSRFQSYGILGYQYECPDLFQVPVEGGPDDGKMMYVLAISINPGAPIGGSFVQYWVGDWDGTNFTPRDQAVRTMDFSKDFYAFSSWSNSPGNKAYAIAWANNWEYSQVVPTSPFRSIQSLPRELTLKYYRPTPQFGDLILNNRPVNLSAISSKTLYSKKSAQGSKNNQTVALNGKGAFDIQATFKLPANTNITYNTIGSFEIFAGDGKQSVKTGIQMGEPTFAFIDRRKAGSSFADSNPFFTDKTSGIIRYQANYTEDQYVLGPLPTSAYLDQSKQDRYISLQAVVDRSVIEVFVNDGELAGTSVFYFDNDQIPAKVQVSVGDNKLELVDLEVKALQSIWKKCQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNP2</accession>
    <name>W3VNP2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNP2"/>
    <dbReference type="HOGENOM" id="CLU_013615_8_2_1"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833400" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="146" mass="15480" checksum="CE0B61886246746D" modified="2014-03-19" version="1">MKFTWATALVALAGVAAAADSLPDKLQVGVKFRPEVCDDKSQAGDLLAMHYTGTLADGTKFDSSLDRGQPFEFTLGTGQVIKGWDKGLRDMCVGEKRKLKIPPSDGYGARGAGGAIPPNAHLIFEVELLEIKGPRAAARKAAHSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNT1</accession>
    <name>W3VNT1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA thioesterase-like N-terminal HotDog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNT1"/>
    <dbReference type="HOGENOM" id="CLU_071618_0_0_1"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="353" mass="39081" checksum="E976115658D24EED" modified="2014-03-19" version="1">MPGLQAATVSHLDETSVTSRSAVYRGEIDTTWCIGSVPNGGYSLSIILNAVLAFMRTPEVTATNIKGIAHNDPLLLSATYIQAVTWTPYEVRLQVLKRGKSLSNLQADLYQDGVMRITTQVLVTDFETQKAAAEKMKLKGGEHDPAKNGYTITDKSQWAPEFPLSAPEKCHPPRPFGNKAESGKTFAFGELITVSADPKHIHSTKTSDVLSAGAYYALTPQPRLQLDADKVANGRTSDGKNLIPFFADMFLSPPMMLPGHHDAHWYPTLHLTVEFKRALPKEPVTRTATLSRGRFMINGQHESDTELWSHPDDQHLFNSHKPTERRSWILAVARQTALVLPFAVNQNKTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP79</accession>
    <name>W3VP79_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP79"/>
    <dbReference type="HOGENOM" id="CLU_018787_1_0_1"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="506" mass="55753" checksum="49ABFFBDEC8B4C9E" modified="2014-03-19" version="1">MATIVGASNGEPSSAPQYEQGYDDDTPLFTCLSCSIAFPNPDDQRTHYRSDLHRYNMKRRVANLPPVKADVFNAKILERRAALAQEAETTATPDKCEACDKKFASQNAYLAHLNSKKHKENAAKLDKKRANAASQAGPSTAVAADADTEQVPLVFRVPKPTASDAEPASAPAADAATSSGAAADKKQNARETLMVSEDATEEQIQAAIDAKVASSRRIDPNHECMFCAKSGFGELKDTLAHMSKAHGFFIPDSEYIVDLPGLVAYLADKVSIGNICLYCNGRGKGFHNVESVRNHMLDKFHCKIAYSDPEDQLELGDFYDFTSSYPADEDEEWEDDDAEEDAEDDMDVDGEGKVLDLTTKAGKKSATADAEEHDDQIRYGDSELELVLPSGARLGHRSLRRYYQQSLREVPMGSARDQTDLSRRYGGGGALARRLIAESGMGHHDGDGTLVTGRGGQVIKARNRGEAREAKKHITEFRDRSRREQYKTRIGFRNNNQKHFRDPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPE1</accession>
    <name>W3VPE1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPE1"/>
    <dbReference type="HOGENOM" id="CLU_017206_0_0_1"/>
    <dbReference type="OrthoDB" id="2552716at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="601" mass="63610" checksum="E726035052BAA790" modified="2014-03-19" version="1">MSELFDSLNLSNSGPSSSQLSSSQPSTSKVFWHASPSPGVLRQLNNWTPSRSQDSPTLPLCTQAFVGELKKLPGALEAQSPLVSRDAAKRKLGGSSRKQGRNVSDPTTIKEKTRGYAVLEISDDDEDDAVGGADKPARLLLGDVGESSPESRRRRTMDAGNTGRVRQPSSPSDLSCSSKSTMQPMPAVQPSSQPIGSHRRLDRRHPRRRKRESLMAGLGFSDESGTDCLKLFEDLQAAIRGIQAPRTASDGHAHLALNSAGQSNSGGSGADQPESVRLTPREGLNRTTSAPTSARPSLSSGPHSAPHEDQGEGSQSRRVFRPVKSDHDVFNAVRQEDERQARILQPRAVNVAAQPEPQSKPAHSALRSPSPSEPVRRQSQLHPSAQNVGTETRLETALPLRAPPPPVEASAATRHDQSTAVTMRKAHEGADETAARAAASPVKRSARIEAMQQTSTGKKLGVRAPSAFTKAASASPRKAADGTVVPVASRKVSAPVARARPHALPGMSQARQPGLPRSASQYVASASQAGATAATAASGPAAPFRPPAISRVTPTRQPPKPAQLSSRRSAQQGRVEHAASSDDSFADDDDAFLALACELEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPH1</accession>
    <name>W3VPH1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SNARE-complex protein Syntaxin-18 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01882</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPH1"/>
    <dbReference type="HOGENOM" id="CLU_038403_0_0_1"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000069">
        <property type="entry name" value="Related to syntaxin 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="SNARE-complex protein Syntaxin-18 N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="398" mass="43669" checksum="4B3905D79EE6B2B0" modified="2014-03-19" version="1">MAASKRARAPPSTDLTGDFRQLISERAGQYPPSSSGASGSKALRRKDPPENVVRAHKQWLQQAYVIRKHIISLLGFLFSIRRRYLALGNKARHHQLRDAHEGMDTPDDQDATAGSAFAKWKAFTGPLNDTQRDEIDFQVKVVVKRCLDSIKELERAEEARKKNAPTTPTALSPLNSLLALSTARDSSTSILASSLISAHRASITQYLSALLSKASSLQGDMQEARLRVQREKTRSLANSRLELQERAGAAASQATAASTAPTVIRGSVGGSFDPQLDSETDLVGKDISAQLSASQIEMFENESSELIKSLESDLASIKKAESRLYEISELQTQVVQQLEQQGEVTDQLLDEAIGVGTEVGRGNEELRKARQRSREADKFLSIFLVGSGLALLFLHWMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPI0</accession>
    <name>W3VPI0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPI0"/>
    <dbReference type="HOGENOM" id="CLU_003043_0_1_1"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="3">
        <location>
            <begin position="351"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="2">
        <location>
            <begin position="896"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1179" mass="128295" checksum="BB83574B55355CF3" modified="2014-03-19" version="1">MIDSAPPLIEEKELVRFERAQEYLSLLSQLVPSHATTSTLNPTSSPNKTKTQTQDEVLGALTAILDEYQDQAHLLDPYLHRMVSPPVEALQRHVRALSGSNAVASSDILPEDSIARLSKLVYAYTKVRGYKTIVHYFPHEVADLTPTLAFLEHLRDQADGDNAEAASTCWQVRYVCLLWLSLICMIPFDLAKFDSARQTAELSTASRIASVAQHFLASPGKERDAAAVVLGRLFQRTDVQRGSHFVAFLDSSAKALASEASNSFQATGILQALCQVVKTAEPGFIAEHFAPIQAIAESYAAPTSSLERNGLVAKFRTKLTGRLAMKLLRPRARRRANKLHVLGAGAEAAIRTVDDEEDESDVPEEIESFISVLIEALQHNDTVVRYSAAKGLARVCDRLPTSFLDQVVEAIISLFQINIPNLDAGTLDLSAVSEHTWQGTCMALAELARRGLLFANTLAEALPWMLRALLFDVRRGAHSVGANVRDAACYVVWALARSNDTQSIRPHAMELARRLLVVATLDRDVSIRRAASAAFQECVGRLALFPHGIDVIRMTEFYAVSVRRTAFLECAVSVAQFTEYRPFVVDHLVDVVTVHWDAAMRRLGAQALARIAVAHPESLLELTERLVRRITTADTAVLHGTLLSLAETSAMSRTLTGNVDEAMRVRAFGLLDLVRPSAFRALGAASLVQAACQLIGAAHTATLTTSPDETQTWEKVLNLALARPEEPVHSAAADAIASLGSSVDLTAKIHSTIEAWPHLSVAQQQSNALLLGAVEYTAQAPFNAAIAHLIAIGQAGTKDAPNALHAVNIETRRNAADSLARAVLGLGDSFARVCTAATLRSVVQAMLAGLNDYTMDQRGDVGSWVRLGCIVGLRDLLVRLQTLQLDVDEWLGDAFHSVVAALWKQAAERIDHVRHTAGTSVLAIYRAYSSSHESKPHGYDVVQSTYGDLDEEVEEPKFREAKAAFPRIVHLLRVQAYRAPILEGLVVSVGSKTDLGERIIGPALVNLTSGPDYARTELLGDLFLLAKRCFGDNRVFVPALHTINLVLEGGGSQPVAEQVVRLVRMATSGIQRIKSIPRLTASARLAINLLLAQPERQPGAGKMLLESVPLFLAHALPTVRTATAEHLYAILSSTLDLDSESVVDTWTQLEFALLDTDWTTPPSTTTIDAVTKPLHELFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPP5</accession>
    <name>W3VPP5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005274_0_0_1"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="660"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="840"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1137"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1248"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1369"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1152"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1391" mass="144935" checksum="51C50674CA59026F" modified="2014-03-19" version="1">MSPVPSPHDTLGPSSPDQARSGEADGNFITKSSAQPHTPRESAENRHHPGLQQGVLADGPSTPMTPTRLVSTSAPPIPPNWLELALKGRAAALREAQRKTAPSSLPADMQQAPVADPPTASSTSLQTDAVQNAATQQSPVVKTEPDVDMQATAPTLTAPPTEASLPDGALAGGLVSANSPPPAPSTSSLETSVASVQPPPVQPPPIAALALASQDAPSASGPDALRTEIMGPPPSLPLDLAYPPLNPVTTEATAPPTTSKRRGPAPAANGAARRSDPVQAPADFEPPTNLNGKMPYALFQTVQKSAVPASKSAQTTLAAQRYVHNAPTPGSRNPHDFISAWENAARSDRRFSAKAGVMEKGAVNAKSAVATTMEQAEHGRNSSVRAPGQQVAQIREAEITDGAKFGQFLRESTADDAAAAGQQPSGKAESSPSLDNKAIDPLIADVLTDADSVATATGTRETSREASAVPETGAQVAATEIGEPAQPSTATGSESASIAPSSVVPQQAAPPTLSADTLESVDASPSAALRRTPSNRGASLQASQSITSAYADPMGLKKHRELLAQEAARARRSPSAASAGAASAPHAVPSAGASKKSNTAARTIVPPSLVEPPPGMMHTPEGRLRVIPGIAGAVVPTASSSSSTDVQLAPRLEDKGSANNDFCEVCLGHGRFVCCDGCPRSFHFFCMNPPLDIDEMPPSNAAQVLGPAKANPVQKGKAKAGEPGAGSDLNMDEMWFCNVCVAERKPKAVSRPKGLGPFGYLLPILSQQNPKSFQLPADVRTNFKDVATANDGDYVNAAMVRQFKPNRHGQIEPRDPYRLKDKNGDAVLCYRCGGTALPAASDQHPASVGSTERRSRAVSEAGSASAASPADHTIREGTGWRKIVSCDFCSLHWHIDCVDPPMLGMPSNLRKWMCPAHSDHVGERRRVARIGAAVPKTLDLPLPSAKTIGPGKHFRTRVLNNGDIDIIPDPMEELMGANGITGSLQTGIKEIPLIPIPGVVDSPTLTDGGSKLASKIRYRLPEKVIRTDFWSKLHGDDASKIGSVFYLAADELVHRSPFRLVAAEDGAALTGEDVSRYRPFGRRDYQRSGLDSLADIASARLAGDALAVKETPGLIRPSRTRQLMATALGIYLDNSDVPESSLRSSLKEPESLESSDSPLSSLSDSESDAGAETAAQNAAQREVATPVKPAQVSQPAQTAQPVQPVQPVQPGLSEEELIKRIAMEAASGVSSGDPVRLSKRKAAVAAESAMAASPNTPAKKLRSASPAVRTTPMPVRTGAAAGAVPASAQVGSPAAPATGVKKIILKSNGVARSGKTEPKGISEAQAALRTAYHLAGQYADERREIEQLRAIRELMRLKGPDRLLEFLLSPNEPAGATKPPSDAVQATSDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPU9</accession>
    <name>W3VPU9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPU9"/>
    <dbReference type="HOGENOM" id="CLU_299590_0_0_1"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="5">
        <location>
            <begin position="601"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1001" mass="106292" checksum="0AC4397D69593FA5" modified="2014-03-19" version="1">MPASASTSAAKSSRMRLSQRHWVQLIEAWRSASPAADARDTLVDEIAHHAQTICREVKDKQWLVTAFHLAIHAVLLEDSERAPEARELSRREQLGQQLLQLATHSVAAPWLSSLKQQHADARLIATAQEALQRFEQLSKRLTVFQQLHALADKMALPVLPLQLVLEEPTNSVLLCIASVPQGAEMVAQLLKSCAWLAEESAPVRWTIAAQMVAAAPPSQEAYATLGKHGMLIAWKNGREASAWQTVATSAPAVSLREWAEFYGKALAAMRSDSEADVLLDALARQCEGQDVQDAIARLRSHLASKPSVALQGNGKQQATPAEGRKETARFSLDAVKSLSAQVVSAARNKDATAAVAQQLVAEHDLDAVSQRLTALIDWNDGGDTRAFAIEVIAQAARSSASSELARVAAATLYARPAVGGFRLDLEAPEPLMHAAECVLAQLAGQAHATTNPQTKLARSLRCALALDAESVVPACQVLALVSSEDSEEEVAKSMQMHVRWLRSIGALLAGQGDKPRLDLCWLAAFGGDRRDTAGKEDDEAQTKQLAALESLMDAFGRANAPPSSLGGRPERAGADAGLLRFRAAWDGFFHSTLEVCGGESALALVSRDKAMRLLLGQVLRTGDVDLFTSLSTGPNALGGEEREQLVLDVSSSLFDQASVASTRSKDVRLALGVLDALPSSPRATAQRDFIDAACRLGSFKIKSIRHAGRLLEPAEMRSTTDKMDLVARLVASQEGVHRSPELVLDLAHRLCSLDAVAGGKGMVEVRVLAMLADAATAAEDFDAAAAFCQRLVEKAQRSRMGDAGVEVVWKSCLQLSKHPMWTDTAGRIGMLAHAMALCPPHQLAGMLRQWNALDQQLATEIDEGRAVAKKDGARAGIHAGLVGSAANLLPLSFSPLSYFGGASTAGPKTATRQEGVDARTARLFDFDGVSGAAEGGGGYVDPAERAVNAARAARDFLGWKKSAGDDKGAGGAGGAGGVGGFAGFSLSRGVGWLIGEADRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPV4</accession>
    <name>W3VPV4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPV4"/>
    <dbReference type="HOGENOM" id="CLU_041940_0_2_1"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="344" mass="37522" checksum="2795004DA2C0E391" modified="2014-03-19" version="1">MKPYWILRHHGSSSIRSIHHDRHSLVVGDETGAVSIVDLQHLRPTVGWNAHTDSVLTVISLGDHVLTHSRDNNVHLWKLPDSSPALGTLSQVDGAQKPQLVTSVGVNALNFSRCAYNDARIAVPNALDAAYIDVIELQSGVRLVEAIGRPDIKRTAGSRMPIVMSLHLVAGGVVAGYEDGWVKRWTLDGELVWQTRCHSESVMSTAISTKFGVSVGADDRIARFDLLTGEMQLLQTKTPGKASVAIAPDANTFVVGAWDGSIRAYSMADLTELGNLSYHSDTVECLEFASMPNQDDDTDDDDDDDDDDDSSDRHSSQHTQPARDNQLVLAAGGRDGKISLWKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ07</accession>
    <name>W3VQ07_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/M-ATYP homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ07"/>
    <dbReference type="HOGENOM" id="CLU_013300_0_0_1"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="628"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="630"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="722" mass="77646" checksum="540B8CBF31452915" modified="2014-03-19" version="1">MAGPLSTRPISSVRDQQTSPQPPSSNGTPHLKSEKLASSDPSPRVQAILGTPSDRSAPTLSSDDRHSSPFVPSARSSEYSFDRTSTTSFGHRSASTAATSSASHDPDRLPSIAALDFPKSDRFVHPSSAWTHSHPNAMHNAAEPADPSAPRRAASPPPPSIRRGTSPAGRVSNHSAEWDMRSDRGSPLVGARRPGVPPPASSASASAAPAGAVHSAYSRDFARSPLPSYRDDRDFGRSPVTSHRDSAYRDQPHAAHRELSPPLNLPLKRKVSISSDAGSRRPDADRMIDRGTWSRADYAAHSAYPDTGYYRNRDRAESPERTYSSSYSRDAAYSARHIDQRIDDKHYSPRHAHPTSPSSSRIAYRGYDAGAPAASQYHSRRISGRYSPSPRSPSYAPRQALVAPPAGAVAPPAHDPYSRSAPHSSYARRSPPPFAADPRPQLPPLSSRAAAPSRYADPRARYTPPLEAVHAERLSPTPEPHAYSEPFYPDRRLYFARERIQDPEMDDYYHGPVGSVGSRGRYADYAYDPYGSPHAAPYAGHVGKPGNGAAPMPIPSPGMAPMAAHPGARHHDGRLAYASPYGPGDYMGHDPRDMHAHAGMGRPGGAMGRPMMAMPATHVPPGPSAGIAPPPRRRGKLPKPVTDLLKSWLLEHASHPYPTEDEKRSLCSMTGLTLSQVSNWFINARRRILLPTGANGSPGGTTAAQVKAAFSADSPSPPPHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ25</accession>
    <name>W3VQ25_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ25"/>
    <dbReference type="HOGENOM" id="CLU_2122109_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="114" mass="12226" checksum="2319A574F9BA8CE5" modified="2014-03-19" version="1">MILLQHHSLSARTDRLPSTRVAFTATPIDGATVTTTLPLERAAALSTPPILTAEVDLRVGFSAEPAATPPNGSQPRLGLSDDVACFAVCLAWLLDRARPRSPATWRRQDVLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ38</accession>
    <name>W3VQ38_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ38"/>
    <dbReference type="HOGENOM" id="CLU_1215222_0_0_1"/>
    <dbReference type="OrthoDB" id="10527284at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="228" mass="24232" checksum="D73722387A434012" modified="2014-03-19" version="1">MSGNSGPPGSISFYRSNINIFLGDVRHAGNGSNARLNLGDAINAVVAAANAAANAAGNVSLILGDATNAGVAAGNVRIISGEATNAGVAAGDAVTTGTDPDQSTTWFRTKHWVPEHLFEPFEGSARDIPGFHRIKHGRFVRDGVTGNTLVVWAVARRDAPYVLSRAMGLTGYQAVQISRALYDVILEEAHRIRAQRANEARDASEDARYHLGIDEDEDCTYDEANLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQF3</accession>
    <name>W3VQF3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQF3"/>
    <dbReference type="HOGENOM" id="CLU_061635_0_0_1"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="39"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="338" mass="37641" checksum="90013578CB02CFC8" modified="2014-03-19" version="1">MTLDLPSPQRQDSYLPIPAEYEEALQKAQAQFEEHNDPAKESEWEDAGEREDVKLFKKTNPENAYDVPIVKGVTLVENATPSQVLAVIQQPGMRKKWDPRFDAATQLERYDAQTYLFYTYLKSPSYFVWARDIVGVQRNKVSDSGDRITVIQTSVAADQYVDEAGSYSKSRTRATLEVSAWDLVQQGSDTKLEYVVKIHLNGSLPTSVVSMVATETPMCVGRVRDVYYTNGHLPYDAAQDKGDKSSTNTILVYSEYEDGDGTEATSGEKRWTIWYHATGEDSLKLKFDNQRLYPSLNVAVEGDAASDVTADLDQEAGIVSVKVAEAAKGKGFSLVFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQS5</accession>
    <name>W3VQS5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQS5"/>
    <dbReference type="HOGENOM" id="CLU_443531_0_0_1"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="251"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="616" mass="68654" checksum="5B3D6E31517DF8F0" modified="2014-03-19" version="1">MEAASQSSPAKQPARLARSVGRSSARLPPSSHWSVAELHFARSTLRVRSPPVAIAIHLAWIAPATAASSSDDKHALHLRASRVSALVPRSHGIIGTRHTTVPIPACTTPEQALASTLWIEERPSWPFLHHVQRAAQRRQAQPSATSRPSPSGPLVLHLATHLQPCGELNTALRLPLAPDEERLRPWLRPLALLSASSFFQLTFFFLLVLFKIACPPSSIRVSGFAALDDPNKVIKVLASDGKTAEQREIAYTNCKVIGNGSFGVVFQAKLVSPSGSDATEGSSKDSDEVAIKKVLQDKRFKNRELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPSSGILKLCDFGSAKILIAGEPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAVEALCHPFFDELRTGEIRMPNGREVPALFNWTKEELSIRPDLISRLVPQHAEAELLSRGIDVHNFQPVPLESLKVTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQX3</accession>
    <name>W3VQX3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQX3"/>
    <dbReference type="HOGENOM" id="CLU_042084_0_0_1"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="273"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="502" mass="53403" checksum="0E5EFBDCE5A144BE" modified="2014-03-19" version="1">MTTFDVVGAVWSGWWSADFSTLQPPHHLAAIRCDPTSSVPSGTATSTERSSANLIRTLANNRPTDGHGLIRLSLESRRAGLSICGSCILSDLRKRRSCAVSNSLKIFAATMDASAPARPSWAEIEEATRSDAGSPATTLVDSPAWHFDDTIVTDFGPAALDDEVEIVECADCRKPVLRDALSFHQQNCKLARDIASGRISPSILEGDPKKRRMMEGKLPPGRDTHRSCFTDAPLFTAMPADDDESILGDDTGIPLTKKQKKEKRLAEEKRKGGRKNKGPIDVDKQCGVINDKGLPCSRSLTCKSHSMGAKRAVEGRSAPYDTLLFEWQKATNPSFVAKLEEKEKAIAAAKAAAAAAPPKEKKKKGVKDGKAKGGAAGAGAAGAGPAGTAGGAAAFIEDDDMDMFDAGADEDQMEQELMAVLGSVAHAASRDRTMPLPLATRSFVGSYTSRAKRMRNLRELLREGLAPGGGAYGINGYATWNNFRPGTYPPNSTAKKGVAMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR82</accession>
    <name>W3VR82_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR82"/>
    <dbReference type="HOGENOM" id="CLU_487618_0_0_1"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="480"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="556" mass="58745" checksum="90049CB9C9B5686D" modified="2014-03-19" version="1">MGASTDAATFLSSWVQRDQKLITYRLLSRELRIHVEDAKLALSAFYDSHSEKTELDATYVLIGRSKHAAVAKDADDKDAQPEASSSTAASLSSNPPRNYLDQRIARRQAADGESSQLIRLVSADNLDEAKASFGELTSCHVYSVSPGRLRDATQLTAIQHELHSQQRYTDVWQQTNRGADLGVVINPSIKDNYDPSKAIPSLGAPSAPALQVKTEAKSSTAAAVKSETSAQDAKPSAAAAKAAPSAAASGGKKSGLDWSRAKPKEAESKPAPVKKEAAASTGIASKSKRASARKALLGSDDEDEDDEDGGSRLRAIAIDDEDDEDDDKPEKLGYADDQADDEDEDVEMAAPRGSGKRADARTQTKSQAAAQRKQLEAMMDTDDDEVQVVEASGSASSRNASTGQAKDADPDVEMASTTVTETMNGSDAPVAAKRRVRKKRKIGTKKVRSKDERGYTVTKTVDEYESYSSEESDAPVVTGSKRAAASSAKQKSAAESRSTSTSASASPAPSAPAPTSAKSTPANSAAAKKASGATPTPAKKGQQSLNSFFTRKPKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRJ1</accession>
    <name>W3VRJ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_01475</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRJ1"/>
    <dbReference type="HOGENOM" id="CLU_029942_1_1_1"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834815" description="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" evidence="20">
        <location>
            <begin position="20"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS64233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="537" mass="58542" checksum="726B28D2A0CE57B5" modified="2014-03-19" version="1">MASTIAAAVVVPLGMLALALPPLLQLEASASTATSPAWPPFAWLSHVFLSKPPLLTSLLDILVTPKQRGTILYYDNAFPGLFAAVGLSILGFWLTSIAISRTKDVFAARGFQGRDLLKSNATPIPESLGLPTAAVYMALLFLFIPFRYFSSQLQGVSKTGDDWEGRMDGRMGFPHHELASFLSALLSFSCAIVLGFLDDVFDIRWRYKLPIPIISSIPLLMVYYAGGGGTSVVVPGWPKGLRSVLGSIVELGPLYYVYMSLLSTFCTNSINILAGINGVEVGQALVIALSLCLNDVLYLDPRAGQPGSRSSTELLRRHLLSLYLLLPLVGVCMGLLRWNRYPSRVFVGDTFCYFAGMVFSTVGILGHFSKTVLLFFAPQLFNFLLSCPQLFGLVPNPRHRVPRYDAGSDSLYPSIQYFGSGTDADGELPNTSKSPLRPAGLVATWVLKVLAGLRLVQLDFYDDQKRRIKSTTNLTLLNAILVLRGVRHGPQAKRGDAPFTGPRIGEHSLWMHAMACQLAGSALAFGIRYWIAAVVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRV1</accession>
    <name>W3VRV1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01819</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRV1"/>
    <dbReference type="HOGENOM" id="CLU_019279_1_2_1"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="35"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="327"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="499" mass="55274" checksum="C978580BD1E4C9B2" modified="2014-03-19" version="1">MAHPAASQPYHHSFAPMTSHASHASSGSNVVGVHYRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKSDAPQLRDEYRTYKILAGCPGIPQVYYFGQEGLHNILVIDLLGPSLEDLFDMCGRKFSIKTVVMTAKQMITRVQTIHEKNLIYRDIKPDNFLIGRPMTKGANLVHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGGLPWQGLKAATNKQKYEKIGEKKQSTPIKELCEGFPEEFGIYLNYVRKLGFEETPDYDFLRELFTKVLKSSGEQEDGVFDWMLLNNGKGWEAGTNRDRRDDRERHRETRASAAPQASAAAAAQQQQQQQQQHAALARNGSKGARKSGGAQQHMQSERSQAAQLRASHGDFNQNGSGYGGVGHASNVAVHDATVAGIPTQNGTREHSHVGHMTPTGMSSGNLDARGRGADARQAVGIANGEEHPAERKTFGQKLVDVLTCRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRW6</accession>
    <name>W3VRW6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Splicing factor 3 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01849</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRW6"/>
    <dbReference type="HOGENOM" id="CLU_013259_1_0_1"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="10">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="10">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="693"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="590"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="83206" checksum="F25B6B3FC322A2B8" modified="2014-03-19" version="1">MQPPPASAHNPLRHGKRTAAQRGPVRFIQKGAAGNAGPFELMSTSVLRIIHLLGTITFSLLDPRTPSAIMAPSLNLPAPAHGTDNTLASASAPSTSKFASTGGIIYPPPELRRTIDKAAELIAKKDPSFEANIKSAESNNPKFAFLKEDDAYHPYYASRRDAVRRGETLTPVAVDAADSTSQILRQSDVGPSGSTNAAAASSSQAPAEPEPFEFSADLPNITAVDLDVLKLTALFTARKGRSFATSLLARESKSYQFEFLRPSHSLFTYFNHLVEQYQNVISPSPALLDRVKLGAYGTTDPELISQQRAKPALGAGRGGARPALLEQVKARAEWEKHAHERRKKHDEDEEKQRQAFNEIDWQDFVVVGTVELTETDQHIDLPAPRSLREMESMTLAQKKMASMIMETTDTAADEDVEELVMPGRPSSSAQPSAPVVEEVQAGRGGTIKVRKDYVPRGLASRAKPSGSAAMTKCPVCGDEVVIDEMAEHVRFELLNPAYREQRQQLEAKKAQQASLQAGADPTYYLKQLASARTDEDEQARLHREAEERRLAKEKEKIIWDGHAKSRNAARELLAKNVGLENEMNRLSGRPQVVLPEYGPSIPGAQGAEADGADPTNDRPIQLADSAASLPARPSTHQDAGPVSAGVKRPAETELSPPPPPSAPQASASTLAKKSDGSLHPEKTWLEAHAHPTVTLRLALFDGREEAYEAALKSTIATLRDYVHQDVLGSAVAASKIKIKVNGKPATLKQTLAYWNLTNGDTVTADVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRW8</accession>
    <name>W3VRW8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRW8"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_2_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="76"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="607" mass="66037" checksum="E7300AD37507A2D5" modified="2014-03-19" version="1">MSNLNSGNSDVVEHAPQSRPVMATNLSTASSVGNKDAESELSKVGSHTTTTSTHPPIDDAALQQVRLRRALSERTIQMIALAGTIGTGLFLGSGKALATSGPLSILLSYSIVGVVVYLTMVAMGEMSTLVPASGAFGVFSTRFVDEAFGFSVSLNYWINDAVSVASDLTACQILLKFWVSDDVFPGWALSLIFLTFLIAVNVISVRGYAELEYLLSLLKICTIIVFIIIGIVVNAGVNQTLSYLGFRYWTIGDAPFVGGFGGWVSSFVTASFAFGGTESLSITAGETRNPSKTIPKTIRNVFWRIIIFYILALFIIGIDIPYNMPGLKSKSAAVSPFTLVFQQAGSRGAASFMNAVVMTSALSAGNHALFAGTRVLHGMATTGQAPKFLGTVAKSSRVPWVALACTASISGLCFGSSYIGAGDLWNWLQNLVGVSNQLSWAAIGVSSIRFRKAIIKQGKQSSLVYKNWTQPWGPYVVVIASVLMILVQGWTAFRPFNVSDFFSYYIEIGFFVVAYVGWKLWKRTKLVPIEEMDLYTDTVQYEKDLRRRRRDLIRDGAGDQLPVLVEDDEEADDEEPREEEKSTSAEPVDKKQKAKAFVGRASQYLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRY4</accession>
    <name>W3VRY4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRY4"/>
    <dbReference type="HOGENOM" id="CLU_276600_0_0_1"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="24"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Plus3" evidence="13">
        <location>
            <begin position="895"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="511"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="630"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="751"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1086"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="781"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="874"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1086"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1150" mass="126682" checksum="8BF5CE87602D3E3B" modified="2014-03-19" version="1">MGFLSRVEDRPTPSAVYNWRVWVLSFIASFASIMIGYDSAFVGGTIALPSFLKSFGKLSNNTSGNLVSTYQAGAFFGAFLGHPLGHFWGRKRGLFVCSLVFTIGAAIMTAASPSTHLTPIYVGRAIAGIAIGAASNLTPIYISEIAPAPARGQAIGIYEIGWQIGGIVGFFINYGVIQTLPPSVKQWRIPFAVQLIPGGMFMIGTFFLVESPRWLLQRGRVEEAREKLSYIRHLPVDHPYFVEEFNEMHAAIDETRRAAGGDSYFAPFKYLFSRKHLVRRLAFASSLFLFQNGTGINAINYYSPTVFKSIGITGTSTGLLTTGIFGIIKTTGAALFILILVETVGRRRLLMVSSSGGAVAMYYIAGYIAIAKPAQHKKSSLDAGGTSALVFFYIWTCFYSFGYNPIPWVYGAESFDNTARPVAQIFNAASNWLYNFVISQATPHMFAKMGYGVYLFFATMMVISTVYIYLFMPETKGIPIEEMDNLHEKRPQRHAHKMVLEELRTRAAERRGEAVLADQAESRDDASSADEKEANQSSAARCPSPPLAAESERSLFTTTTPYLASSAPFHPFYLLVGPVKLSICCTPSQSRCLERSFTLLDTSRSILDSSTQAAATMAGALDDELLALAGSSEDEGSRPRTNKRSPSHGTSSLAKKRRLDLLDESGSGSDADAPGSDDDAAPTRRARPRASSSSDEVANPYPYQGIYKSARDMEELMAMNELEREDILARRRDELNQRRQKVELANLVKMQQAAAGASKKAARKHETKSKRRVVRGGGDGSDSDLSESEDEDADGDSDFAYSGAASAAKSRRKKMPGQTDAKSAKLSELRKKRKEKAAGTTSRFSDDEDKVRSRRGYASSSDDDSYASSDEDDPYSRRGKDTRRSRADEGGSSEPPSLAELNAARISRERIEQRLYAPRWKDVLTGAFIRFAWRRAREDGQGTEEVYRIHQVTDVHEKPGKFYDLSDDRSGRWCNVYLSFEHAGEEREIRLSNLSRSPFIESERERWLVTLPAYKQKIPRASSVAAKADELEKFFDTPLTEADIKKVLEHKKKIRTQAASVMGSGTPSTTDSDGGKSLEARLAAVHEKNRAKDRSRPDAKLKHKLAPSTAASGTATPTAPEHRQPAPQITNKFVTLPNFAATVNVDLGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS36</accession>
    <name>W3VS36_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GTP cyclohydrolase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS36"/>
    <dbReference type="HOGENOM" id="CLU_029639_2_0_1"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="8">
        <location>
            <begin position="254"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="7">
        <location>
            <begin position="493"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="73782" checksum="F548ED651497F204" modified="2014-03-19" version="1">MPVHPIQGAVHLMRTQSAPAPTLAQLPACTDQGEDSRPMVELPKPAASFPLLHVRRLQLLLKLLLASASLVLHLRPNRLVTATSALSSRPLPSAYSAWDFKHLGHCRSVQPRLISSLVEKMTTSTDQILSRILDELTELKVKNSHLEAKVDALQNAATLPSPSSQVRRQSSSGFTALGVHSLSPSQPADFAFGTSPPPQPLGPPAHPLGGLPQTNGPSPIGTPDLGAKKLPPNGAASPSQPASSSSTAGYYSSRVILTTYPGQVGIKPLPLNWASEDPHKRGPVVASRHPNSIRVRNAIGAYGGSYSVYRSLAIAMGQLNPNHRPDYTNTEPPFDIPPNPSWFDPSKIVAMDPWGHLAPQVYKSEFESGVDIRPTASLTKAHIKMPELDKAQASGVFPIDGKIVVKSIRLPGVAEDVDPGCEVSVSKAAVDPVWYLPGVAERLGVTEGALRRAIFEDTGGSYPELLTRHDLKVFLPPISGLTVYIFGRPEDLRDPTKEVTVRIHDECNGSDVFGSDICTCRPYLLFGIEECIKTAQRGGAGAVIYFRKEGRALGEVTKYLVYNARKRGTDSASNYFKRTENIAGVKDMRFQALMPDVLHWLGATNITNWISMSNMKHDAAVNSGIKIKNRYELPEELIPADSRVEIDAKIQAGYFSATKQLTEDDLKHTVGRAWEDIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS80</accession>
    <name>W3VS80_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone-lysine N-methyltransferase ASH1L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01948</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256589_0_0_1"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000082">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="619"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="667"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="836"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="930"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1006"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1102"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1257"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="845"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1006"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1269"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1303" mass="138136" checksum="791D54DF13B2B7BA" modified="2014-03-19" version="1">MPPARTSRRSGLAASASSSSIASPSTRSQRQDAPLTSGSAARLDGPSTTRATPRSTGPLAPALAAQSRQSAERDSVQITPTDSPASNSFNDPIIIDDSDDDANPVGATQPLSSLSPSSVGNPDESTSTTTLDQSYATSLTSDLNMISDGTLTSVSSDESDSDVPEKSAKRGLPFATPPRRTTRAVRSTRIGITATPVSSTGRKAPSQTPSETPTPSRRSARIVSSGSSVKKALQRRDELDAKLLASPVRRKPDALDPPSSPPTKRQPGRPRRSATEASLMQTANSPATVQPPANPLVQNSGSAASRRSSRLSLPAAAEPKDVQTKAANKADGESQEPEAQPKRGRRSQGAAVLADNPPASVNGSRAVETPPAKRGPGRPRKITPDEESTASIASSSSAPTRSSKRSFSDLAKAADAAPGGTLEQSPRRKRGRPREQEPDEAMDEEHGATPTGIDSWSAQAEADAIARQQAIDMLDENVSELSDASEESQTSSAPSQPAALPRRRGRPPKDRSLDGDSVKRVSRPEKGGKKFHVSGLYAGEAEATPSVSSTKPTQERNVVFPNPIHFGAKLLVEERDFCLPYPIYQTMDQLREKVHAKRKPPRYQQISKNKYYSRPKLQGEVPLCNCQPGSGCGSDCINRMLQFICDPRTCPNGNSCTNVSLGRRTGIKTAVAYYGRRGFGLKTLEAIKKHDFIDEYRGEVINLSEAAKRVTEEYKATGNYYLLDYDSAAGELLDGGRKGNITRFANHSCDPNCRIEKFIICGTDEALSAEFQIGLFANRDIEAGEELTYNYGWAAFQPRDTMTGAPTAQVPTEQCLCGAANCSGILGGKKAPATKLSASDVASGSRKKAAKGKGKGKGKSRKTAQTTARPRLRAMTPMMSATRLSSATMPASARLSAAGSRSSRKREETQANLVTKIVIKRMERSARMAADTVASNAEPSAASKATPESTIAKRGVEVAAPAPNAAGPSSQASIPTTVRPQTAVRLPLATLGTAASAMPIQNTPARVMSEGSTPQASGAKQSVSAQDRVASGSGGASSTALSKASDKNASGPNSRTLLAQSLASSRLGNKFGRAATVTRGTKDRRWSAAQAMVSDDDDAAWNRQEAAQPTPALDKAVAGPRRRGRRKLVLTPEEAERRAVDRRARNAFLARVRRASKRGIVIQDPTQHPLKKISIQCTAAPENTYIPDLPSSLVTLGMTTADARRARNAFLARVRRAVKRGFPKDLAIKMAAKPLPGDGSRDTPVMQAQRAYLEQLEREAVSEMEADARAASSRDAAQQSAPLPSATPAADGSVHASNQTAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS91</accession>
    <name>W3VS91_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS91"/>
    <dbReference type="MEROPS" id="M43.008"/>
    <dbReference type="HOGENOM" id="CLU_700444_0_0_1"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834542" description="Peptidase M43 pregnancy-associated plasma-A domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="11">
        <location>
            <begin position="269"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="409" mass="43410" checksum="8015A5E09FB563A9" modified="2014-03-19" version="1">MLHFLKLAPTISVALLVLQQQMQPSGGGRALARPVRGEAGSEAFPVLATSPRSTGPAADAGSSANADPPAVLKALDAMSGSKPQTGQSATPYMAINHGEGGVIKPGQSSDHSQGGKSSDAAKAAMKTLQQPRTRFCAQAANTNRTVDAISQNLVSAERKRLAKIRKQRQAKSTGHNATDARSLTDAKLLAEQSKTVDVVWHVIHSGSSGNLSDAMIADQIQTLNEDYKAYGFAFELNTTNRVENASWYRNIMPDGSLQDQMKAQLRKGDAKTLNLYSVDFNNGLLGYSSFPWNIEDLTNDGVVFQYSTVPGGSETGYNLGKTATHEVGHWLGLYHVFQGGCVAPGDYVDDTPPQSLATSGCPAGQDSCSGGGPDSIHNYMDYSSDACLTEFTEGQAVRMAALSGEYRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSB2</accession>
    <name>W3VSB2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01983</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235908_0_0_1"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="741"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1433"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1516"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1172"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1315"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1402"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1703"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1315"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1410"/>
            <end position="1423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1856" mass="204140" checksum="9B91C2D98B3FE217" modified="2014-03-19" version="1">MVARTRKQAAQAGATPDSSAAASSRSLKPSSTPQKQRSSPRSKASMPSASAGAFKPPTSSFCASTPLKTTSEKGEDESKLGGSKASMPHAATIPLYDFDLPLELDRPIGSRTSVFCPAPYVELCDTFTRWFPDQARDMSATILDDAPPPNDAASRTDAQDDPAGSHPPATGAQASGQPSQAQSDAQHPTKKGNGKTGKHNAKGKSARPHDQHLEVEFVPQVIDLHALLLPSDTTDFLTRALSEHLVQAYAIMALAPPSFESIRSAADTTGTSRDGKASNVDRKSAHDGSQGQDETEAEDEAEDENEDDEVETALLGYLVPSAFREAAHPLANLDPLLVSKEWIQLYGEVTLAFPFLPPESEVFDENHHAYASGGNLCPDCGEVHGDFRYPEPLRPRNKVPSTRLLGVLNVQVGLEPIALQYGAGDAAVDGFVGSNDDLKHTGAEGSFSLARALRLAIPTIVDWEDSFIAVDVDANTFWDRNESFYSLPPKQSTLARHMVLDKVEAVDLPAASKSPSKKRKKQSRRSAPYMDQSWSARSDSFDEHDTARRARQDSSFKRKLSDVPLGEEVSRTDPRLGDPASETHLPLDTNIASLLEACRPPADGPQVFPPSDMIPTPLLGYQARCLAWMIRKETVLDEDVDRLLPNWVPLRCKTSAHIMHRRMQLEAGREALLDAMHRDLSPSRRNANVKAARAAVAPVESFAGVNGSSDGPKLKREPYIDPIELNFYFDQVSGMLSLRRFTCRRSEPGGALCESMGLGKTLESLALIASHQRPDNPKLLSYDTSRSARMIAEMDPAEQPFVSRATLVVCPAALVEQWMDEIRKHFRSRGVQGKPQHGADPLAQSGVVRYRHADFAWDAESSRGDVRAMAKKRLTKVDIVVATYEELAHQLLESHRIRRTANSARTPLLEVLFWRILLDEAQIVAGASGKATEMVHELWRSNCWMATGTPVTKGIRDIQGIFAFLDHDPLAAPRFFREILQEPFSRGCVEGIRRLRSILPRYVWRHTQAHVEHEMILPACRAEVLEIDLKHVERLFYDKEVSKYRESFAKKAAQGSANVSQPTFLVNLRQLLSHPQIADQLMFSHNFSRLSFAELFRQFCERAESERDSMRMQAIVATLQLVWGHDFYDAEKDKRHWRGGRPVLQPSDIRNLLETALRTATMALQDQARARNAVEAAAANPGDPQDVTTTDAQDAAIPPQTLVSDTGNNDGQARPGTELAPRINLTWEEASYWLRVLQRKHADQLSGSTVAINAEEIVPPTRWDPERPTRTFFDKEFKNADDKSVNLADSRFHLVVQDASADDMGFDELMAQIEAGRGADSSSSSSRKKQRRDAAIEPGTLKKSRLRGNASQRKQARVWLYKPKERLETTQVKLMMLSADLQPKEHEAAFLRQKLQEVQIAEAQSHSEEAGNSSTGPLSGDSDTSVLASTVECPICFEPKESIGVLPCYHSFCTDCIETIVKKNPVRQTWWHHSPGPRCPSCRLTFHPDRVTRVMERGRSASAEANGEVIGDWSGKITGLIVDIKSRLQADATQKAVIFSHWPKMLAFVCDALVQNGVSAVVFGGNEANQAEALRAIRDDDHVHVILVPFRASAGAAGLTLTSCNLAYLLEPALDAALEAQAVGRIHRIGQRRETTVIRVKMKDTIEDAVMRIAEERSRRGMALATHGDTVATGAIAGGSDATQPSTSVNSSALSIVTHGGTASYSAAADGPPRGPATGSQVREQSIKASVAASVGTSRESDPTALTMAEVGLILGFDIAEEKRKLRERRDTIFRRAYGTVDVPNSMQHMSIEELDSLEEELHMYDDASDGEDFMHADMDEDMDEDMDEDVDDGMDDNMGDGMGGGQDDGFHLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSV1</accession>
    <name>W3VSV1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSV1"/>
    <dbReference type="HOGENOM" id="CLU_013093_1_1_1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000286">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF87">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="8">
        <location>
            <begin position="303"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="380" mass="42255" checksum="0836ACE27C6B0728" modified="2014-03-19" version="1">MGWNTWNAFKYNVSSELLVQTADLLVSTGLKDVGYTNLVLDDGWQALNRSDDGRPQANVTKFPNGIPPVAQHAHNVGLQFGIYMTNGIKGCGPKDPGSWGYEEIDAQEFADWGVDYLKYDNCGTFEAGTHPPQSRFRVMGNALRETGRDILFSLCQWGDQFPWFWADQIAHSYRISGDITATFSDTGKDCACKTAYCLNTGYAGCSVMTIIRKMREISYFQHPGSFADMDMLEIGIANMTLDEERTHFSFWAALKSPLIIGADLRTISNESLSVLRNEKMIAVNQDKLGAAVEYLADISKERAFQTWAGRLSGNRTIVLAFNELNDTITVDVPFSAVPGLDSENRYKLEEVWSGFSGHVKGNISATLASHETKVFILKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSW4</accession>
    <name>W3VSW4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSW4"/>
    <dbReference type="HOGENOM" id="CLU_054362_1_0_1"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005725">
        <property type="entry name" value="PRK07539.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="266" mass="29000" checksum="56AD374EF97C5E06" modified="2014-03-19" version="1">MAALRTSSRSLLRSVAAAAARSNTVAVASGSSRASAVRALSTSASRASDSLFVHRNTDYNNPDIPFEFNEENLKMAQEIISYYPPQYKKAAVIPLLDLGQRQNSGWTSISVMNYVAKLLEMPPMRVYEVATFYTMFNREPVGKYFMQLCTTTPCMLGGCGSTKILHAIQDKLQIKPGQTTADNKFTLVEVECLGACANAPMVQINDDYFEDLTPESMVNIIDKLSAGEKVKPGPQSGRHSSEPAQGRTALTSEPYGPGKHCVPEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT67</accession>
    <name>W3VT67_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT67"/>
    <dbReference type="HOGENOM" id="CLU_1409354_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="193" mass="19915" checksum="A1E07A0022DAC8F7" modified="2014-03-19" version="1">MRTHGGTSSGTSGGSGREREKTAQKCLRTRALVGFKTGVKGALGCAGPLQGLSGGGGREERERGGAEGRKRVGLKAGKDSGPPPRSSEPDAVSTSPSDVQQTPRIFPLWAACITHPLPVAAGGPAGQVDVASFFSLPCDASPALRPAWMRFNIGQGVVRHLVSPADGMERPPYLAFFSDDTPSTSYVGTSSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTB8</accession>
    <name>W3VTB8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTB8"/>
    <dbReference type="HOGENOM" id="CLU_101141_0_1_1"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000104">
        <property type="entry name" value="Thioesterase family protein (AFU_orthologue AFUA_2G16350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="172" mass="18770" checksum="8C4483016DF07922" modified="2014-03-19" version="1">MAEASGAWPHVSTYQTRWLDNDQYGHLNNSAYYLVADSVINAFLIEKCGIQPFIHPGDSAPAPSTDKKQSRDVVGLVISNSCRYFASCSFPAPLRVGLRVVKLGTSSVTYQVSISEYGQHGVHDAQQAAALITSTHVFVDRITRRPATMPKQLRVPLEGLLVKIAGSEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTI1</accession>
    <name>W3VTI1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTI1"/>
    <dbReference type="HOGENOM" id="CLU_357568_0_0_1"/>
    <dbReference type="OrthoDB" id="2556653at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="784" mass="85160" checksum="437755DD26B5CE1F" modified="2014-03-19" version="1">MSSSTTQACFPSSSSRQRPRPPRCRREDEAYHPPIGFLPPSDKNTLAVPFALAYLMWCATCKSDCPSRQAHSSGRPHHHGPVCALGPAAEHGEILTSMSAELRCIGTSFKACMHQMRYFVVWDTEHRCVRIDSLWNSSIDAQLRAYGFDEDALGQVQPGMLPKCADKQAAMATPAKNKQGTAGKTETARSRDKMREQLQSETLLADCARFASTAEADAAERTHMSNKQPLAQVLRALNRAVLAFGTRHSDNLIYTELAALVALLNYAAAFYHISADVVEQHLQDNYSQSLVEHYFFAVCSPRWTSIEAEEHAAARDRRTQPTRARRLRELQQVATSFVPDTMELRDGAQLVLHTFVWINYTSFRSADEAMAAMLHSLIPLLQTVVMRCAKQAYVLQRLLCTAPTTQHVESTSPPSPTEVQWDLVNLSSVLQNLSGSEVPLYTSFYRGIAQEGKRKPKRRPHVENTVRAPAMAHLYSMYAIDVTLDTLCALGRALAKQTREHSPLAKAKSAICTKSQHNCHAGCTHPDAAMLDDIAILSAKLRRLERTQPNWIPMLSPKKTRKKKSAAGAESKEAFASIKTALLDTLAYGNNGGGTSGDPKPGLKTVPKAVPEPMSKPVSKARVAQPVVSKPAVSTPVAPASVKGGSGKATDTKAAVAPAPAKGDIRSDVNPKAAAAPAPGQGDSSKTAKKVFGPEPPPSMPLPMSRNVAELIKAMADHALAQPDYVAPPLSGIVDLPANLATLGALMTSPSWQPPEWMNEFCDQLSRNEAASRGILELAGLRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTM2</accession>
    <name>W3VTM2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTM2"/>
    <dbReference type="HOGENOM" id="CLU_285306_0_0_1"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="7">
        <location>
            <begin position="583"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="694"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="772"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="844"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="924"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="924"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1086" mass="114691" checksum="4806F1F82F19E942" modified="2014-03-19" version="1">MAGALSPSMINIQVPFADAGHLKAPGYLSQPTSSAPSPQKKQRRSSPSKGRSLTPSMSASSSSPLKKGRTGFKRTTSTANIMDTVMNSRVATDHDAVPAFRLGIPTSTSNIFEYSRSSPIASSSQTTLADLENDEAANVLSTPRRGKRVGNVHMGWESPLDADQTPTAASVAATAPHTLPKSSRTRASAQSVSVEASPSKRKASTAFASELRLSRRSLVDTAGWASAAMISSVPLAEDRINSSPGFSPRFIAEPAMTGLVNAETRDPLAAFTNDASPVCSQNPRLVPVEVEGLGRVAVHPDFAQQIAESPRAAQSDAHRRFSTASEREAALLRGSDSEDSAARSENGSSTDPTSAGTPCPSGVSPSFSLSSQFPCSEPISPTKKGATSASYAEHHAADTQKALSALMRVAPTDAMAQQKLWCPRLGGSAATVVAKLPTLDWPDRPDGPWSAAGRHIDELKQKRRQGIQRWLESDSADETQEDAQESSGAAYRHHPMVAKALLDRARKQHRTQVSAATVAAARADSPSKRGRKPKQPHLLHVHETPSKRRGRKPKVAASIASSSRKSVATGASLARSNTSAIIGCRCGIDDDSIIMVQCDGCRSWLHLPCVGVNTVNDLDDEWYCDDCCDAALTEHLSPASSMPTSIGSYAHLSTPEALEAALAGQEPVFTLPSGTPIHRYGVAVSSSIALAPSPPLLSVGDRGGRSTAKRQGQGRSRAERVGWRINEPGSPLARKSTTASSGVRPAVPETPSKSSEATVDFTDASATPSLLAGFSRADWEPTRARRASERQTTPTRVLGMSTPSRHASGRKPSHSGPLSLGLCDDEPPHADLFSTPSRLASGGSWAYRAGGQPLGSQTPSRSGGRHQRIDSFSGGLLSTPGRDFLSGAFGTEPSTSMPSLVYSSGYIDGLDDHLSGDGFYSGSNSRAWQLQSPTSSTRAARARQPSGFGTPWSSSLLKTPELQPRQAHTSSVRSGRYDTSDDFPPSSSPFPRTPTFDMSSPRFTPHGSHHSSGALERHPSHLGLGLPSSSSARLHKALGADLHKGGASRDDRSLSASAHAKHRQVSTEVPMGLGIGLDLDDVLDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU63</accession>
    <name>W3VU63_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU63"/>
    <dbReference type="HOGENOM" id="CLU_418036_0_0_1"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="656" mass="72118" checksum="C708AF694DDAFA95" modified="2014-03-19" version="1">MVKVKREGRKAKRTTVPPRASEVDAAKRERSLRACTRCRARKQRCDNGLPHCSNCIKGGVACEAFPINVVSRENLLQLYDQLQDSTRRNSVLQEELDVVRLVNHDPLSQFSVLVAHRASNNHAGEQAIWTEQELKHEGNVAYTHNQRRERPASPALTTKDKRKNAAPLSRSSGQQAPAVPALEGFMELLGSCFPAVAPAVCLAVNSVTTGRTHECANNVAVMASLPMQELYSILAMRSGLAGQAAIKAPTSRMEASVKETAGMFFAAADMTRVAAIMLWTLLALVKRRVEDLLRLDKVLTGFMKVWQTRAASEASAFLCDAMTIFYRAYSWIHLQTAIMGGSLQIEVSSVISLDTMDASRCKLEMRSFASSFQVEVARLEYQTLCLFSMPTGCLTDMQHAEAVWALLTTLKQLSDVLEQCTLLLGAGFDSATREQDGLLRAKLAVQLYGVFPRLLARHNADRRLWRWLANAGPLAATALSLYHFAWVQFGWLGDHALDAAVLADLLAAFAWIHQQQALHNASRPDWAKTVEAAIELGEHSLARWPHLSGTLTATLHELRAVREYAAFGAPLWPPVPAFSASSPAQTSSIRTPTGSEVALHPAGWLHWASDDANASLAAQMAADNPWCEPELHSAPLRDELRTAPVLVYMDEANRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU86</accession>
    <name>W3VU86_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU86"/>
    <dbReference type="HOGENOM" id="CLU_085878_2_0_1"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000397">
        <property type="entry name" value="Probable DNA-directed RNA polymerase II chain Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18961" checksum="44C8E8C752666E1D" modified="2014-03-19" version="1">MFFLKYLTHKTELHPSYFGPSMVEFLNQKLRDDVEGTCTGKYGYIIKVVGMIDVGQGKVIPGSGLAEFNSTYQAVVLKPFKGEVMDAKITNVNKMGFFAEVGPLNIFVSSHLIPIEYKFQPEANPPEFVSAADRLVKGRKVRIKIVGTRVDANEIFAIGTMKEDYLGPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUH8</accession>
    <name>W3VUH8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUH8"/>
    <dbReference type="HOGENOM" id="CLU_025401_1_0_1"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="175"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="702" mass="77595" checksum="0718193677E33C44" modified="2014-03-19" version="1">MSGNIFRDSYAGQEPHEQQNDAAQAPANRPKKKSFMNLPGGGKAIFAFSLSLFAYTLQTEFAQYVQQALNYRKPFLSLYLGHSGFLLLFPMHLFFLKWTTKRPITHYLHLIAQNLRWQLDTAPSSLPDPRADEVRRRLSRASGRGSQAFSDADHAEQGGMIRRKISFLEETFGFNVLRLAGLFVVLTIGITIPALSWYCAVPMTSMADITAIYNTFSVWALVFSVWFLGEKWEKRKVFSVLLACFGVIIVAYGGADHRKVPKPVDPVHGKPPADTDAAVRLVYRSVTAAVSRVFTRREAPADAPVSSAHNPVLGDLLAFVGAVTMAAYEMAFKLIGTLPDENKQAEMYSAVPGGRNRRSRSYVRYQDSEQDDSRTDYETEGLLRWSQSEARATDGDARALHAGNGDGAHHILGDDEQDVTETAKKHELDERRSLSTLADKLIGQERPDYQSITPPPEPSNTYPEEDASKIAKEAADRVRVHAKAVPISEAKRRDDDEDSQVTESELDEEEEELVLAGATRLHRTRSHVSTHHLADASYADGDESSHDVSAARISTDAMRPGVSRRSSTYRKVHDPSIPPPLPFGLHANVMTAGIGLTTFTTFWIGIVLAHQLGWETFELPHNLRTYVSIAMVVWCGIFFNAAFMILLSLWGPVLASVSCLMTTILVEIADVLLGHRLKWISVLGCTLIGAGFAVLVGGGSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUT9</accession>
    <name>W3VUT9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001197_0_0_1"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="126"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="437"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1127"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1543"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1630" mass="179850" checksum="A88EBF7B1246C13C" modified="2014-03-19" version="1">MSSPLDRAASTDAPTHRAPRRAGGSSTSLSSLPSRLVAPPPPPTLKPSSPDVQLDLSSAASASTAHTHASLRTANDAPRPRSVLPSSSNPRPTTSVIESSQLWKTSAAKRAEKSWALQTECALYSDAKFKKYLALVERTLASFDSVSEWADFISFLARLHKAIQAYPAYNVVPRKLIVAKRLAQCLNPALPSGVHQRALDVYHHILSVVGPDGLRRDLHVWTSGLLPFFQYASTSVKPTLLAIYETFYLPLHDDLRPLTRALQMALLPGLEEETGEYFDRTIRLLDRISDAVEPAYFLQNLWLTLITTPSVRLAALNYLTRRMPDLTQHDDPTLLVGKDLGLMVRGLAHALDDDLLLVRRNTLDILVTHLAVDKPLFRRFVKRPDQILLVRSALHVVLRKDLSLNRRLYTWLLGADETPAAQIAFLDENALDLVRSALAQGFHGASALDTLERQKPYRIFVSLLDKWEIGQSLTRVLALDAFHAISLQVAKRQEEELVTTAKMLFEVIDPFLLYGRFLHAITQTMQSKQGSTEDGRSPLSLLCFIFKAFHIHDDETKHIHVPLLFAAVTQLLDQLLAHDQDKDGASTSQMLDALELLKLLITAMPSRVFVRIAEPGPANKGDSSASDAPDFWQRAHRLYTSSETDSQHAARHFVGFQDAASASALVELLSHVALQCGQRLFVRALDVFADLMRVLDGSEAADEIALVRADASSAPLRTHKLHWNADAWADSLMPFLQSVASFAQVERIVEVLISCCICRALDRPLVLDAPTRVDRIVAALLRYLSPAMAPYHVRAVELLWATNKVTRRSRLETALAHQLSHNDAAARAAALTAFGAYWRLSEDVSTDELRTPLLLVLDRLQASDADERQQAELWLRAHVRSYVKVVDPLVHMLVRNQPAQLAPATVNLDGISVVITHVEQPYNHELVVYALRTLAALVRFGGPGLVKALASTPLSASLSTATKQLVRAKTLDGAATYLDVVLDECVEWMRTYPAVQLEAQLAASSDTLRAAAVDAMHGLLQRTAIAPSRTDELERELIEALLVAVHRGATATVEALLRCWQRARHDTRGAEAVVEVLAIVTPSAQILVTFLCDVLGTRMVRGDADRSRRTASSNSAGAVNDATLLLFFEQVLERMDPAEATQVWPVVIVLVKEFVASALARKVHVYPMLRILTALGEKLCLTAGMEERRTRRELQDNYAKLVDACILLSGRSLDASTWMRRSGREEDVGVEREADELARALAPEVSGVTEAINVFLATRALAALRKMQLDTDRVQTLVANAVYYIAAPAARTRSEKLQVEPHVVALLSELVRMPGTVKAWRSTVGDLFGDARFFSMGVSSATRWKPIVVALLTQDKERLADVLARVSTASTAANIFANRELEMVSRALSLRRLSFALFAGERDAFVVQLAQIQEKVVELLRTAPSEVLQAEVYLCLRVVLVRFSARHLTSFWPVLMTELMRLYDGVASEPERFEQSADARQLVLSTLKLLDMLVLLQPDDFQINEWMFITDTIDAVYPSDDFHADTLLDALAATFSRDTAASSGKAATGSQHHQGGAGAGAAANGQRRLQLGEMRTISSLGEVVPFLHSVSQNAFEAHYSDAGVDVEHVEACLLRDMFDGDDECRSGADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUY3</accession>
    <name>W3VUY3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUY3"/>
    <dbReference type="HOGENOM" id="CLU_012543_1_0_1"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833438" evidence="3">
        <location>
            <begin position="32"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="943"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="280"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="632"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1047" mass="113207" checksum="6FB307574DF6B3F0" modified="2014-03-19" version="1">MRPFASSKTGSSKRQIASLLAIFCLVSAATSASLQGARIELSQPPSERQLSSYDGHAEPRYARGLPLSPLFKRHGDDEHEDDADEEQKPDVHTHLGPEHHGMKQDDGTSTDHQEPHAHTNDDAGHGHEDVAKATATTQHTHTHEHGHDAHSMHMDGPSPLLVPDASIAGSELRELPVWHSHGGHGHSHGSGPVREKLNETLLFRAKGPDPLSYIEWDFAYGVGSLAQLQRFTADADVLAGTEKMGVVDGRWRKLFDENDADQRKAIAQDIASRIEDAQGQEPGRHRGLLVLHVVTAIVSCFVLLPMALVLRAAHSSLAPLVSLLYLSLLGGSMFISIIYKALTPRLYPDNAHGSMGWAILWISLITLGSDVFRLLGQIWSAVGALRSHKRAQSNAWLPTGSVANATGGPQSWRDVVGTMLGRGQSHKLSSESYDALEGEAMLSEEAQSDAHELDVEKHMHHHTAAPRRSGFSSRSGSGSGSPHRVHFDEDGEPAYRTRGASAESLVEPVNWVGSGSTAVSSPDGGRRNDLASGDSQVGPERLVASPTTTACNTPRNSIFGPDSTLLPPLSLKSVSLWRKQAHDDKAGAPQDASHPEAISYPATQPRSSRLDTFRAVLRYTRVVAARSLPILAFATSYTGLAVYTGSCRSGYKNVCLAHGIKGGIFFWFGLLTFGRYLGAYADCGWAWNKRPSAAAGARGGSSQRLAAWRRNMPSAEFVECLVIFIYGASNTWMERFGAQPGDPYTIKQIQHISIAVMFWFAGLMGMLLETRFIRNMLSFPIAYHHVAAVPLREARRRHNASRLRGGGAGSAARAGYDDADEELEMLVETQTQPASYSASFNPFPALVIGVTGVAMAAHHQDYVYEVEIHMLWGELLAGFAVLRCLTYFLLWLRPPTASVLPSRPPTEALAAFSLCCGGLVFMLSSEEVSFAAMRSGYGDFMAILNVAVAVVALLFCWTTVLMMLKGWAVRREVKRSLYGAQDEVLDLGTNALHLNVAANEVAHPRHMRASVTGGNAAAAAPVATTASAATAAATTDPVFVLEDEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV30</accession>
    <name>W3VV30_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV30"/>
    <dbReference type="HOGENOM" id="CLU_2334539_0_0_1"/>
    <dbReference type="OrthoDB" id="3356378at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="98" mass="10709" checksum="7D1B6BE7A2C6D396" modified="2014-03-19" version="1">MRSTAARLLKLKPVPASAVLSLRLPPAASRTKAASASSQAARTKPTMANVAAELESKLVARQELGSNVRFSEHISNKELYWKVSKPQRDVLKKVLREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV31</accession>
    <name>W3VV31_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV31"/>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="612" mass="66379" checksum="07F77F98D5811EAB" modified="2014-03-19" version="1">MAAAPETFDYIVVGGGTSGPVAARRLAEYLPDAQILLLEAGPRHEDILASTMAMGWEGIHHSRWDWKYTSQPMRHANHRQIHLPRGRFLGGSSGANGTLMIRGVRNDYDRFAALGNDGWSWDDVLPFFKQSETFHPDPDQLPFDPAVHGDSGSLHTSFHPLAPISQRIVDSFLETGLEWKPNMFYTGDNQGVGHVPRTVYNGTRTSGADFVSGPNLPSNLTVRCNVQATRIILTDGVDGAKVATGVEARDDETGAPLLFHANAEIIVSCGAYNSPQLLMLSGIGPKHQLDRFNIPVQHDAPAVGENLQDHIITFNFFNVSQPKLTHDHLVFDEGALATAMGSYMTDKSGLMGRFPFGAFVFRRFDKELEANYPEWVEAKRRAGGKDPVGAENGMPHVEYFYSELYGGGPQHVHQPLPGESAFALITLLFNPQARGTVQLQSRNALFPPAIDHAYLSHPLDLAVLAEANRFGAETILKGSATKDVVSGAWPVSRTMPSTQDEWKEYVRQQAGTCYHASGTCAMGPSPAPSEVLTKGAVVDPRLRVYGVANLRVADASILPLVNTGHTQAPAYMIGEKLAYMVAQDAGATSTLPERLGSAKASGKNGARTPAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV69</accession>
    <name>W3VV69_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Caleosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV69"/>
    <dbReference type="HOGENOM" id="CLU_062049_1_1_1"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30407" checksum="C2F29F44D711A6D5" modified="2014-03-19" version="1">MQLTSYGDFPRTIDLDPFFDNTKLVYGDAGTKVPYTPQNTWTDPNGSAKDYLEKTKGLTTLQKCASLLARSMDGQHVAYFDGDCDGVIWPSDTFFGFHAMGFGFFLSAFAMLVIHGAMSYPTLPRNSKSLRNWLPDPYMRIYVANMHRSKHGSDTESFDRRGQFRQSQLEAELSECSSRYGKDALSYGDVLAMFRERRDVFDLFGMTAFLLEWSATYLLIWPADGYMRKDDILGVYDGSLFVVLAHRYKNGLGGGAFDSKKGGVFDTKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVD2</accession>
    <name>W3VVD2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVD2"/>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_1"/>
    <dbReference type="OrthoDB" id="2017946at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000006">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023264331" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023264330" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="267"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="494" mass="51697" checksum="6DAFBAC8EF3F00C2" modified="2014-03-19" version="1">MISRLLSRSTLSRGVRGFASSSSTLDASAKLNKPARFATPIAASDIPKGFVVSSTYAGIKAAISPKPAGGAVAASNPNPKPDLALIVSTVPAAAAGTFTRNVFKAAPVVVSNEVLVEGAKAASGARVQSVLVNSGCANAVTGTQGMQDALACVELVKKNLAPHPGLAQSAEGRETLLLSTGVIGVPLPMPAIKRCIPHLANGMILRSDPESWRETARAFMTTDTFPKLRAKTFKLGDTECRMIGIDKGAGMIHPAMTAPGGGQLHATMLGLIATDAAIAPAALQTALNRAVTRSFNCISVDGDMSTNDTILLLANGQATARRAAELDESSPHFDAFVAELTGFCQELSQLIVRDGEGAEKFVEISCTNAPSFDVAHGLLSRLVTSMLFKCAIHGEDANWGRILASVGGADPTLTAHIDPTKVSVSFVDPAAQLPAITVLSNGNPVKVDEAEINKLLQKEDVKIVIDLQNGAEHCTYWTCDLSREYIDINADYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWI8</accession>
    <name>W3VWI8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWI8"/>
    <dbReference type="HOGENOM" id="CLU_1124388_0_0_1"/>
    <dbReference type="OrthoDB" id="10262162at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833345" evidence="2">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="252" mass="26317" checksum="C48B7DA0AB17461A" modified="2014-03-19" version="1">MKLPILVALSLACTASCFPVFNDVSKRLLFESGHQAASADAFGGTTHTFQTNAPVVSGSGNSVTTGGAQSSQADATGGRVDQTLEQVEKFFGLSKRQPLLNEAVEMAQTVKDAFRFNSETHPGGASAGMGFKFPPEKRLLASGGGMDQMDPVGMLAKAFDMFEKPLQGIEPGFVKRLLAHAEEDARADADAGAGFECQANAPVVSGSGNSVTVAGGQMEHADAEGGSIAQEIKQSLGLRRRHHRSHARNGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWK0</accession>
    <name>W3VWK0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_00207</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000443_1_0_1"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000079">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000153">
        <property type="entry name" value="High-affinity cell membrane calcium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="704"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="912"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="983"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1266"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1346"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1391"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1518"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1633"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1663"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1688"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1719"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1812"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="499"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="782"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="1264"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="1600"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1058"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS65146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2161" mass="241585" checksum="E65D5AA05534BD42" modified="2014-03-19" version="1">MSAQPPSSHDEQQPPTTATSLVPPTHDPLRSPASPQYRDSVSASSIPSHHSDIYINSYYYGNEHMHDFGTIASPVHSSNDERLVRRLSWDLNQQSASQPPFRTSHHRAESSIDAGILDAPLPLSPQPLDDSFPPPRRSSLPLANLHPASSLNDLHAQPMQYGYSRESDATYTHQDHDHDRAILNHHHRTASPGALEDPPPHLKSSADVYATAGHNPGNFAKARSNLDRLSKSIRRISRRIVHHNQQTHLPLNDHDADQDDSDDSARTVHPSPSPPSAQPHISPTTHHIQLLRGKSLGLFAPENKIRTALASLLAQWWIEPVVLLLILANTVTLVLQSAQSVYQHPRPQHFFSDTSNIILLAIFVLYTLEILARIIVSGLVINPPPLYAAPLDDVDSSLKPAQSQHSEHKRQMSRSNTLDTLGTLGGNFKHRAQRVLAGDMGFTDHHQASAAPPPTRHPGRRLNQSETSMFLSESTAPSFWHNANTPFAEAVEKQRVKSVHYAFLRHSWNRVDFVAILAFWIAFALALTHQEATPNHHIYIFRALSVLRCARLLTATSGTTTILHSLKTSAFILLSVTFFTGFAMLLFGIIGIQSFQGSYRRNCVWLGDLNGQPGQNNTLSQLCGGYWTTAGDKLGHLLANGSPSGSSPKGFICPRGQICLEQQSNPQSNTQSFDNIVTSLLEVVIVISSNNWSQTMYDMIDADYYASCIYFIIGIIVLNFWLANLFVAVITNSFATLTARTQRSAFADQKLQDPAADAEKQPSSRGRLKSLALGFKRVWGYTKYLWILAIIFDVAIQASRATYLPPSELQKRSRIELYFTLAFDLEIAMRFLAFVLDGDWRAFLASKQNRADLTLAFITSIIQIPVIKNSDVYAWLTFFQLARFYRVIAAIPRMRVLLVRAFGSLNKMLNMVLFLLLMVGLASLIATQLFRGDIPQDDDGEWTEMTFKHSFNSFLAMYQIFTSENWTDVLFSATSTGVEFKQAVIAAIFLSGWFLFANFIVLQMFIAVINENFSVAESEKRQQQLEQYLRRNEPRPITLTQRILDKISPYRYLKRRNAAHTGSAASDPARSDQGAGLGARTNKIVGGSKIDARTDEKKARPLSMHHVVDTSTATAQRTVNTVRKMLRLDKPEEAVPLDNLNARRLRSSIHADDMLQPDARAHAATYDADPSDKAAHEFASNRRLARMRSDLGLATGNDDAAVFLQRSPSDARIQQAKFIASHPSYDKSYFLFSNHNRFRRFCQSLVPSSHGERLFGRPVSPFRHKLFQIAVFLAIVGSVVSAAIATPVYRRDYYDRYGLIRASWFSILELSLSSLFLAEFAVKTVADGLAFTPNAYVLSVWNALDLFVLVTLLVNVATELAVIGGVSRFTRALKAFRALRLINLSSLMRDTFHAVMIAGAGRILDASILSILYIIPYAVWGQNLFAGLLYSCNDGSDAIKGKFECAGEFMNSPGDFNFLAPRVWGNPTEGSVYSFDDFKGALLILFEIISLEGWIDVMTAAMSVAGKDRQLQNDNRQVNALFFLIYNLVGSTTVLTLFVSVIIENFQTFSGAAYQTAAQRQWIDLRRLIVRQRPSKRPKRRPGQSLRAWCYDRTLNKNGWWSRGMTLMYVATIVTLMTQQYADPDWANRLRDALYLGFTAVYALDIAARLLGLGWRSFRENPWNLYDLFVVSGTLATTLPLLTGANETQAIVQLQKLFLVCVALKLVQKNRSLNQLFKTAFASLPAILSLFLLWLTMFLVWAIMLVEVFGLTKWGANETYAKNFSTMIGSLVFLSMISTGEGWNSFMHDYTVSPPQCTPSANYLTSDCGSEAWAYVLFIGWNVISMYIFLNMFTGTVVENFSYIFDLGSKAVLSSSDIRHFKSSWARFDRARKGYIKKEQIVPFLALVKGGLEVALYPPECSLRVLRAALSQEVPASPTVAGGKGRGALDFLKSASPLRSPLRDGKAKDAFFNWPASPTSLTPQEDAGQTDAERLARALASVDAGELRMRRERFNRVYHEAVLVAHPRKGVSFTDMMLVLARAKLIDAHEALSIDELVERTAMSERIDHQLRLDRVRGLLKVGYLRRRFLALRAQMHTDGVPTITLNDDHPSSSRPALALQIPTEREEEGGLRSGVSREEVVRRASPAIESFEQTAWGEVMKRIDSASSSQHHTDSKDGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWQ9</accession>
    <name>W3VWQ9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252093_0_0_1"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="144"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="313"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="1393"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1339"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="632"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="893"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1339"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1358"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1436" mass="143928" checksum="78328AE35DD24481" modified="2014-03-19" version="1">MQSPAPAGSAASAPPIALSPVERSAFAHLFNLADPERTGIVTGDAAVSFFAKSKLPPPVLGQIWAMADSANNGFLTPPSFSIALRLIAHAQRGEPVTDALIKRPGPPPTMEGVNLPLTAQLTGSQSAAPGATNMPGVIEIKPEDRARYTRIFANSGPSGGLIDGDRAKEIFVKSKLPFDKLGAIWNLADTQARGALDLTDFIIAMHFIQNTMNGSLNSIPAALPPGLYEQAKGSGGVGSRVVPGSPLAAQNTGGSASGFGSAMGIQRQMTGSNFQASSAFQSPQQTISPPAAAPTATAAAPAAAAPWDVTPEEKARSDQFFDGLDVSKKGRLDGAAVVPFFMQSKLTEAVLAHVWDLSDVTQTGTLSKDEFAVAMHLINAQLAGKPLPQELPTTLVPPSMRSMDLPAAVNPHQSDTQKDLFSLMDDDPPAPTISASSAFITPSPAAPVVHNQPFGVAPAPAATTAQRSAPGPFDDDFFGASDATPSAPTPFQSSQPAAATLSPAATGGSFGSAAAFRSPGIASPTGVASPSASTSRLGTAFGAGAAATAAGAVAGAAFGSGSGSGSATATDQGADFGNKSLQLQSTEKAVSDLQSRRATLESSVATNASTLAELESRLSTVRGQHDTESKLVKDLEERSQKQNAELKTLREDVIREESELSALKAEKDELEQALMRDREDVRDMKKRMNDVQTETKSLKEQLDKLRKDARQQKGLVAISKKQLATAEADQEKVAGEIEAVQRGDVEAATEHNAAPAHAEAVTSPAASVRSTNPFDRFGTGASASPQPGTPALPPAGASHHGGVGTALAAGAGAGAVLGGVAAAASHHDTDVPHTGVADEAVHDADPFGVQHTQQPAQPAQSLGFDDAFAVPGESTTDAPVQATSADFDDNFGDDFGAGTAAPTGVVADKADEPVVGDEVSRVAEPAAAGGLAADSSDDDDDGPEDVSGYKGHDTAGAAERFPDIDDSTQDVGAAAAVEPKHEERTVPGGLEDVTAASVVTPASSAPVDPSAIGSVAGERTASTTSIAPVSRQETGAPATPAEAASEVEQTPAAAAAAGGLGVAALAAGAGALTVGERGTADVQPEVSSPTDDVPLSQLMAAQNPKAAGVEPSVSPSSSIKTRRAPPPAPVRSGTALSAASPAAAPTVLAAEPTSGTAAPVKPVEASTNPFGMDDFGAGAKPHPTHGDSGSGSGFDDFDSAFEDLGPSEAVPNAAAAGTGAAGAVPQSGFDDAFDNDFDFVPSFSTGAAGAAGAGAGTATTRAVPAAPTGGQKDTFDDFDAAFDSAPTSTATAAAPAAAAAVATQTGTTSNTASGFSFDDAFDPAASTAAPAVSIPASTASTSAGAGVSSPTAAEGTYAPPPGPPPGFNAPPAVPPRSSARTATDEAEDYTGALPDDAGPVKQLCGMGFTRQAVINALEKSNYRTEKALERLLASTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD54</accession>
    <name>W3VD54_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD54"/>
    <dbReference type="HOGENOM" id="CLU_332930_0_0_1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="868" mass="95106" checksum="F4B2FF9B95970BBA" modified="2014-03-19" version="1">MQSHDPTATTNATISPQDTSLPPPVSSSTQFSANTPANAAAAAALGNANSSVKNLSCLQCRKRKTRCDKKYPCSPCVIRGDQASCTQVQQTIASITTSFGSATSPTRELAPPLPHRASISLSQDGQASTLGAAPPSSSSSKNELQEAASFASDRFIGMDAERLYRLEARMDRIERYVLNSRTNSNGAPFVSAADHEDEPLAAADRAAAKQELHIGQDIQDLFEDAAMGRKLKLKSLPIDAVGTAADGDPKEAETDEEQMLDQRSADSSADVAFRFAQFLPPNTSVLLDFYFTHVDWTTRVLPPESPADFLRLSKMQPEQIAAFPVSSAMVCCYFVVVALALHFSDPALLELVGISKKEASRLADTLCTGSQQLLWSSNFLQSQQLEHLACICLLGVYQHNRKEQADGQWALLGSAIKVAQNIGLARLDHGPTSHQPSVSMRTEARRELGRRIWWNLTWLDWSHAVAHFGVYSVHPLQNRTNLPANVEIHGDSLTLHSPDVYTHSSSITMRMRYVTLYREIVDVSNERSLLSRAQIHRFVSKLNEVHDSTPACLRYSPQRTFDAPDQAMESVMLELMYLNRILRLHRVHQLSGFTDDEWRFARKACLSSASCIIRILSLQESSVIHKFWLVTFYLLGAAMALVMELCCARQHDLDATAVRANLSTAISLLSKAGPGSEAARNSRRILKELLNAEDKIREAFARLGGLERIAEEKLDTSGTKDVFLDVLQRVFSASSRVKRKRPLDARQAAAAAGRPDKIKRLAEGESAEHTRESSVASVGEARIDSNNAMQADYSWLNPTDFADMMGDGAGKAGKAAEAVSVGGEARTVASNESDWQGDQTLFPSLDGILSGALSIDEWLGSSYPFDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDT2</accession>
    <name>W3VDT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDT2"/>
    <dbReference type="HOGENOM" id="CLU_013253_1_2_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000223">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834368" description="Peptidase A1 domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="120"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="591" mass="60509" checksum="0336212A359BE6F7" modified="2014-03-19" version="1">MAFQALLSTVAAALVCASSVQAYVLPLQANTELRGDLAEAKAFRLASRSLNDASQAGSISVPMYKRHGALHPDVSKRDPEVMRSWAFRQGEIMKAKYGATAAHQKRQTIGLTDVGPDSYYFAQLSVGTPAQNFNVVLDTGSADFWLVDSQCGTAQNCDSDLNKFNAQSSSTYVGSSAPFQITYGTGAVRGTLAADKVSLAGYTVNNLTFAEAAAVASNTVEYPTSGIMGMGFQSLSTSGATPFWQVLEKQGVLSQNVFTFQLARNIDNINPNDPNINDIQSPGGVFTLGQIDSNQYSGDISYTNIPNNLQNTQGLGYWTIPLDGITVNGNSARIGSNTLAAIDTGTTLIGGPASAVAAFYSQISGSRSAASVKMPGYYLFPCSANLNIQLTFGGKSWSMNPQDFNLGSYPFTNSQTCLGAVFEIDLGSSQYGVPQWIVGDSFLKNVFQVYDGTGRIGFASLKGSEAQIVSVTANAVSSQTPQATSSATGSMSSIGGGLPFPTGASSFASGATATGVVGGGSLPTPSASGGVTSSTPSLVAGSSNGGSSSGSSSGSGSGGSTSGARSSLPSALLAVSTASAAALFAGAFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE23</accession>
    <name>W3VE23_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_06316</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE23"/>
    <dbReference type="HOGENOM" id="CLU_020273_3_1_1"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS59789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="240" mass="26299" checksum="787FAEC0ADD824A9" modified="2014-03-19" version="1">MFDPIEAAVADIKAGKFVVVLDDEDRENEGDLIISAALCTTKQMAWFIQHTSGFICISLTPQRIAELAIPMMVPNNTEKNKTAYTVTVDYKHGTTTGISAHDRALTSRQLADPTLEAKVDDFTRPGHMNPLRYTEGGVRVRKGHTEASVDLCMLAGLPPAGLLCELVDPDDEDGGIASRDACLKFASKWGLKVTTIEMLKKYREEHEGELPNDVRSMLSDDKARGVKIDEQQVVPPTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEG7</accession>
    <name>W3VEG7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEG7"/>
    <dbReference type="HOGENOM" id="CLU_109163_1_0_1"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="72"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="147" mass="16078" checksum="0C635EC1952EFB65" modified="2014-03-19" version="1">MPTHLSKTRKHRGHVSAGNGRVGKHRKHPGGRGLAGGQHHHRTNMDKYHPGYFGKVGMRHFHLTRNSSYRPVLNLDKLWTLVPAEQREGLSASSTEVPVIDTLAAGYGKVLGKGRLPSLPCIVKARWVSSLAEKKIKEAGGVVKLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEI8</accession>
    <name>W3VEI8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEI8"/>
    <dbReference type="HOGENOM" id="CLU_035836_1_1_1"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS59930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38343" checksum="BAFA17508426BF93" modified="2014-03-19" version="1">MASARTLSRSLLRARAFSSSAPTSSSSSWTPVLKPGTLPAYDEALALLSSHADSVRSKAESLDSTHASLSAEDRAALKESLEVAARINDPATLARFAASQPTRYDAADPVLRYLRERVWRNDSGVLAKLMQRCTLMHVFPDVLPGITPTADVQVAFGTGAGFTDHTAEGGDVLAGVFVPVQKTVEPPTVAVNVFHTDKRLYTVALVDPDQPNEENQSYTTRLLALKTNVELSAAECSVDMTSDMVAEYIPPHPQQGTKYHRYTTVLLAQSDRITVQAQRDAFDLPAFAHANRLTPAGIHFWRAKWSEADAETVSMIHRDILKQDEPRYTRPPTLDKVRKQIGDIGSKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VES2</accession>
    <name>W3VES2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VES2"/>
    <dbReference type="HOGENOM" id="CLU_2185099_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="109" mass="11220" checksum="97B7616FDFBE6F1A" modified="2014-03-19" version="1">MGRVDDGRWAALHPFTSPIPALPTSPRSVAHLVLNPPPLPALGRSPSSSLPLLGLRPPLHTTNPPSLATSDPPSLSPPHHSIRIAALAVAIGIAAPAAPPFFISDKAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF65</accession>
    <name>W3VF65_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 3">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF65"/>
    <dbReference type="HOGENOM" id="CLU_072095_0_1_1"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000043">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="175" mass="19184" checksum="6123AE5071F34B13" modified="2014-03-19" version="1">MPSIDSNSPLRLAFPAADIPTECFSLLGDEYELRPLASSDYARGFNEVLSCLVETPDLGEAAWLERFDAMVAANGTYFPIVIVSKSTDRIVAMGSVVVELKFFRGLTRVGHVEDIVVNTKLHSKGLGKVIVSTVMKIAEAKGCSNIILNCSDEKKPFYEKCGFSYSGLQMAKRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFW4</accession>
    <name>W3VFW4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFW4"/>
    <dbReference type="HOGENOM" id="CLU_1652903_0_0_1"/>
    <dbReference type="OrthoDB" id="10493359at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="160" mass="16922" checksum="93C18F97690E0170" modified="2014-03-19" version="1">MLHATDGPAAAGTRPIDALSLVTTAAAFTLALLIILYTSAASSDPLAAQLLQHPLAFRPPTFVCYAAHYSRTASQQASTSSNSAVCPRPARIPHADDNRKCLPSVRACDRYSLVIPAIALVTFPARLARSIPLPPRRRSGVWAESELTDGCLTNSADGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFZ9</accession>
    <name>W3VFZ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFZ9"/>
    <dbReference type="HOGENOM" id="CLU_774164_0_0_1"/>
    <dbReference type="OrthoDB" id="428177at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079:SF6">
        <property type="entry name" value="GH26 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40249" checksum="A16923ADFD848500" modified="2014-03-19" version="1">MPAHRLSALGVDTISIGFYPDEGDAGGTKTYLSHLNAALSSNWPSPHRAPVINVVGWYAQTYPGEEFTGSQLMPLVQDIKAEYVRCGGAVRMVYEASVMPFQSWTGYTRDNPRKAQEVARVMQALLDASSIDDDFAIAEIRLRFGHEVNYYTRSGLYPPPTGVDQGADFREAFDQVALACRALPGHYSRRIKMFWCPNIASTASRAMAEYERFQPTMEYVGYVGIDYYCPAPGCLDAADFVRKMKPLHDKYASRNRPFILGETGLHFDANEGAGTQAKLKWLRVVTGREARSKLPHLSGVSWFNYEKDRDYRLIYVGPTEAAETAAFAQWLYERMAEEDKTEKRGGKVKKLWKTLMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGI3</accession>
    <name>W3VGI3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGI3"/>
    <dbReference type="HOGENOM" id="CLU_096574_0_0_1"/>
    <dbReference type="OrthoDB" id="2576580at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="221" mass="23220" checksum="E4C97E4FED246BA9" modified="2014-03-19" version="1">MTTWSLDGAAGGGAGSKGSLSAAVQEPELDEMKSLGARWNQMAWKSYETDARTVTIMLTNTNKTLLNDDYEIGNALQGAQNSAMVYVPCVAPASGYALLFVNPDKYDHQHKVLYTSAQFVVRPKGSAPDPASGQQSIPSHIQPYLETPGIVLPANKAGEVTNTTSTGNSAESELPKLGGESSAFKSFLPEAHDNAAAPREAQEGLAWALGAITVALILAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH52</accession>
    <name>W3VH52_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH52"/>
    <dbReference type="HOGENOM" id="CLU_306768_0_0_1"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="965" mass="104076" checksum="E6EB7A7F0F35E007" modified="2014-03-19" version="1">MPAFARNVSHPRRGGRTRSGAGNALRTCLSCRRSKTRCQLPDLTVASSATPLSDDKACRRCRSLSAPCVVDDSQRRVTKAGTSRYGLDGLLERSALAHTTQSDGHNLSQPRRAHRAHRAVHSPSVSQADDTASNSLSIDGSAGSIRVRSRSTSNAPSQDHMLSSDLHTTASDDPTPPNSSICIPEPLRPGMLDLLYPDISAALSATAAAASSASSASPCSAPEPSGSANESSASSPCPPSVAALASIDPHCGASVLEVWNPFLYWIKLLRAREPPTTTNDFLAVTLQHLNLLLLSSPCHGPARQPSSATLPDSAPHRKGAGPKIASSRKKLIHRVAQIFLGREPPSLRAIQALILLSVYDPPDLLLRHTPEEGNDPHNGGADADFADAPEASQDSPSPSAAVPALPPPGRALVDLACSMAHQLDLPRIVASATENSECRADSQETPSDIVRFLTLIALFNLRANYLPSRTANEVKAADDLTLLHGLSIQAVLARCDNLSLGAAADARVPACQTIAIRSLASQFKMSSAFVHALRKLRAFPLPISTVDTRVEELHARFRSVVQTALYCFALDTKQEGDSNAADHWLVILRTQATDMELALWSHCIYLELGPHACPMPCADDETVNAPSSVGYDAVFPKLKARNFQGGRFLATVTERCTDLAHVVLNISYELLTAHGEAHSTSVAPLILRCTAVFRAVKVLSQLWMLVLLKWSSLSARLIQALDVLDIAARTLRDANQPCMPELALLVRHFLIRTNEALRELLQAKQDELARSDRKGLIDLAGGLDHDCEVAEVDRDPNALIARSSGNLGTARSDRSQSRSQIATRVDSQAGGIHPLATHSSPRHVESAVHASETQGQELWIGSMPSQTRHSLYQSHRPDHHQHQHAMQGFHQQHQQIELQSPPLHTEQRQTSHPQLGGYGGQSSALWSAAAGTITSPQPIAPHPGLDHESILWDDLWSWDLLDIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH60</accession>
    <name>W3VH60_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH60"/>
    <dbReference type="HOGENOM" id="CLU_326802_0_0_1"/>
    <dbReference type="OrthoDB" id="2552999at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="965" mass="100653" checksum="21AA94D46F5AB135" modified="2014-03-19" version="1">MTKSKTPIMDLETDEDGWIGGSSQSIYAPKSQPATDTHASPPPASKSNTKRSPVTPARQKNPTSSDSNPRSLLERIDMAQTLQTPPPKPRPGQASADASTSSASPSPAATSPFRTTPSQGIRRPGAKIPSPLPLTSPARNNPPASPHNTRTPLSASHPIPETPLKLSQRGGPQTPATPHYPAYQHSSHTPSDGDNSRASGLGLGLTPLKGSVPLAPSPDAMRSPLNDAVHLRGRAASNASIGSPLKQGRTDLHGEPLALGSSFAKSAAQGNGQIDAMLDRLRSTRSGLGTSASMWAPKPASTATSSDTTASTSSTTSHTIGSGFSSSNLLGVQTGLDRKRPGHRPNGLQLSLGQEISVMQELEEKAEEDYAPSTLSSATVGETFKIDPPQDDADATGNDGWYGSVVPPTPVLGCDSPSSDDDNADSKPPSRSLDAFGWGTHSRNPSKGSLFSNLPSSSTLEANWSGDDDDDRKDDVEVFEDMQRAAKAASKDKRSHHSPLPPPPINFAKSRTPSPTHRVLAKSPQLDASPALSAADKLPSQRLSPASARSQLPALESDGDADAETDKPRGGKEERKPAKKPVVALPESATESAPASGGLEKKRSLKRDKSERIRGRRSSSSKEKDVDHVKMTAANASASTKTDASADELVKGIATVDLHANVRGSTPSKPDVASTSTVKQPTPVAQRVQSIPEVKNDLFSSPAVPKVGLPSAAAKEPAHVDVETKTEAGADSTQAAETASEASAKVEEATTPAPSHIDWAEDDDEDELPDLDDWGVTLTPAKPAPASEPKPAASKDAGRGSKPPKKDEPTWRRAEPPRGKPKPTPKAEGGPLGMRIAGRAKEASLSPEPPSRGKKASPAQRSEEMPPPAATPYGRWKQPAAPKDKAAGRPRIAADLGALAKLIAPDEAVKPPPPPGGGRDAKKDEAGAKKVEAVKTPSVADSMHAPKPRSQPSQGAAKKKHAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH75</accession>
    <name>W3VH75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">PaG_04841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH75"/>
    <dbReference type="HOGENOM" id="CLU_076902_5_1_1"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="104" mass="11386" checksum="3A0A20867EB6990A" modified="2014-03-19" version="1">MAEVSSTPAAPAPVGSVTEPFDLIRLSISERVNVKLRGDRELRGTLHAYDGHMNLILGDVEETIYVVDINDENGHETVRVVKRQSEMLFVRGDSVILVSPPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH84</accession>
    <name>W3VH84_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04852</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2 9"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH84"/>
    <dbReference type="MEROPS" id="C01.085"/>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_1"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000091">
        <property type="entry name" value="Aminopeptidase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="539" mass="59807" checksum="903F84A19B16E7F9" modified="2014-03-19" version="1">MGSAASKPVAAKSAETPNEKAGYTVSLDSSRASAHSSSIVNHHAADRLARIQAETLARYTTSAAPAASTEARAGISLAALSEWQDAALTTQAARLAQMTLHNAPIAASLHRRETEVSCAHVFSHAIPYEVKPVVNQKSSGRCWLFATCNVIRHQAAKVLELDEFELSQSYLSFWDKLEKANYFLENMIELADEPLDQRVVGFLKTAPTNDGGQWDMVANLLEKYGVVPKAVYPESYNSSFSSQINWLVTLKLREYTLELREIKRDVQRKLSATSVGASQVARAVADAQRRRKEEQMAEVYRMLVIALGTPPQPDAEFTYNYRNRAGKFVSLTSTPRRFLAEYTGSFDHKQRCSLIHDPRHPADKLITVERLGNVWEGTPISYVNTTVDVMRDAVVRSIKAGHPVFFGCDVGQFSDKTSGIMDPALFGYADAFNISLGLTKAQRIELGESSMTHAMVITAVHINKDGKVERYRVENSWGEAGVGNDKGFMVMSDQWFEQFNYQVVVSRKFVPTHLWTLFTNGVDADTIRLPPYDPLGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHB6</accession>
    <name>W3VHB6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BCAS3 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260162_0_0_1"/>
    <dbReference type="OrthoDB" id="25778at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="2">
        <location>
            <begin position="526"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1312" mass="137808" checksum="D8DD4DB725AC962E" modified="2014-03-19" version="1">MSPRSSDSNATSSKQKKKQVESSPPAPPPCIDQPSQPSTPALPPTVAPPAVSASAHRSPRVFVASALKPVSAIDTVTSTISAISHHANRGISSLIAAHSTATHDATSPQLAASSTTTSTPLRTDGSVSPIYDAFHNAGTPVDPARVQAALSHVHPDHTASRKPAPALLWSRWDRLPHPHHPHAWLPLLISYFDDGCLQALLVQDRNISELLCIPQAAQALLPPHSLQPSANAHLLTAFVRHPLPDSTDIQLFFVLQHQSGSTHLLAYSLDTHQVQASVHLQHHFSPSSDQPATTLDRVDAQITHRYLVLSFASPPSVHVLSAATLEYLQPPLLDAASPAQGRPTPISLSDRLLAYACTTPQHLSPVRFDARKTSNASFQDTSRSYVAPQPHASARVGEMRDNLFDTSAHVGDAARRIRGGVMSGVRTLGEWGSSYWPNPGSSPNNAAFSPSQPSLLSQSAPHNPHPPRPASSASSSPSLPAVDSARANKRLSSGSTVAPLTKSEVNAQASASNPNNACVRILDLGSDARTVCAFAPSTNAVALVAFSPCGRMILTADVLGHAFNVFELPLVGAFASGSQPSASTLLHRYKLLRGITLADVVRAEWSPDAQWIAIGTRSGSVHVFAVNPFGGEPSIANHVLGKIRNPRTLQPFGISLHSAARSVRPHPSAHQDAAAQPSAATKMDAGLATQALATPKYCSPSFIMINVGSSSSAESGADASTPFELLTNDPRSHTITQHALRCWSSQSRTRVAVGNDEPMYSVSLEAKRRFASSTSPRSSGLTHMMRKAGEGLLSAQNNPRLQAECVRVALWDHLLPDTDAVIKHSLTALFDHREIRPKDRSDDIARTRSSSIAKAEIETYSQSPAMLPSSIYLSRQTFFHTRMPVAGKLAAAAASTPEATLRCIPRRASRPIQVRRTARIVSREPSSEAPSSFGDSLSGALDQMSFDPDNLPARSASSHIPSFPQGQRGRSSGWTAGSSIPIRIVAGGLGGIYRAGKELGRGVEMARRRTSGASRTAVSDVDAHYAADAGPSVSFDGEDDVDLLGEDEGLGASRKRHYAARGSVEAHLDAASMPSQASLMSTLRNDGQLRGSQPSSAETPSTRFSEADDAGADGGSGSADDCDWDAIEASRSPAAMHASLSGQSGGAAPSIPGGLEPDSLEDDFTVGRLDEDSGQSTVTQSLSNISALSAGAASKAVPPKELVYALPANTSTRSSLLGQSTGLAGAFEARGESKDARLGVRDASPSHSDGGADSGSQMSAASGLLCEGSKETFTPETASIKIAEEPSPVQAVAVPKISTSGGGKKKKKKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHJ8</accession>
    <name>W3VHJ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_05089</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 9">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHJ8"/>
    <dbReference type="HOGENOM" id="CLU_013325_7_3_1"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000618">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000011">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000004">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="15">
        <location>
            <begin position="26"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="16">
        <location>
            <begin position="199"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="16">
        <location>
            <begin position="356"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="572"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 13">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS61138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="650" mass="70206" checksum="E43BB18BDF222DE5" modified="2014-03-19" version="1">MTEASSSSRSGDDSATAERYTLAKTILGADVFQRINTAKILVVGAGGIGCELLKNLVLTGFGDIEIIDLDTIDLSNLNRQFLFQKQHIKKPKSLVAKQTAASFNPLVNIVAHHANIKEPRFGVAYFQRFDLVLNALDNLDARRWVNRMCIAADVALIESGTTGFLGQVQPIRPGVTECYDCVPKPTPKTFPVCTIRSTPSTPIHCIVWAKSWLFTQLFGADDETEDEQLDKAIADGEDAAEIDSLRKEQREMRDMRAALIKAAAERKEQDVRSVAERIFNKVYKNDIDRLLGMEEMWTHRPVKPVPLVFADVMAGQCDADDSAPAPAGGEGESNGAAPSATNASTLKDQRQLTLRDNAELFVRSVSALATRASADVSVPLSFDKDDDAALDLVTAASNLRSAVYHIERKTRFEVKQMAGNIIPAIASTNAIVAGMLVVQAVHVLQGAWDRARNVSLARGSDRMLTAWPPAPPNPHCGVCQDAYMPVSVTNLELTLEEVVSTVAQAVSLEDVVVYDGSRILADPDFDDNNARSLAALGLVDGSILTLTDEDQQFQAVNVVLSLNAEADRPVTITGKTRTLAPRAQPAPQNEPDSSDDELHEVQPPPPRKRARDDDPAPAAKKSKPTQPAPAPAPAPAQATGTTSESAIALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHK9</accession>
    <name>W3VHK9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_04987</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHK9"/>
    <dbReference type="HOGENOM" id="CLU_084338_0_0_1"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="114"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="192"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS61049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="237" mass="25622" checksum="CC3FA433CD0EF908" modified="2014-03-19" version="1">MIARAALRSSLRAAKAPSPLAQLGARRGYAEAVSDKLKLSFILPHEEEQQTHDRMRCSESRKHAAWKDWQSWRWNAWGAVDAVVQVTLNSSSQLDGSEEEEEQHGMPLASESTANAIYNSTEVTQVNIAASTGDMGILASHVPSVEELRPGVLEVVESSGTKKWFVSGGFATVHPNNKLVVNAIEAYPLDNFSTEAVRSALSEAQRVASSSSSAEAKAEAEIEIEVYTALQAALGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHN8</accession>
    <name>W3VHN8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHN8"/>
    <dbReference type="HOGENOM" id="CLU_030065_0_0_1"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="359" mass="38811" checksum="EE9CD361E22EED46" modified="2014-03-19" version="1">MGKAEAGSLKAISNAMKARGLTKLRFYCQLCQKACRDENGYRSHLESEAHFRQVDAIASSGGAKRVIDDFSTTFQKEFVQLLSRRFGTKRVRANQVYQEYIADRHHTHMNATQWGSLSEFVKHLGREGVVQAEDTEQGWFITWIDNSPAALARQDALQKLERAKMDDEQRQRKLLQEQIARASGASIHAADGSSAGDDKQAAAATDKASQGLQRTGSGPIRIGLSLGTSTSRAEQKSSTTSGQDGTRTEPLASGSSATAKPTPASTAPAATPFKMGFNVLKSTSKAANPLKQGDRSTSGDSSASLQSKSSSAAKGKPPSSMTMAEKIMHDELERKKRKAEPSARSSGPQMQQGVKRSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHP7</accession>
    <name>W3VHP7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHP7"/>
    <dbReference type="HOGENOM" id="CLU_020598_0_0_1"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="54"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="729"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="770" mass="85621" checksum="D67549A739F2321D" modified="2014-03-19" version="1">MSRIDSRATSMTPQHSANMTKTDDSSSTSLTPAATSENSVAYQYVAVQQMTTSRDHIEYQLTVREQPKQSRMCGVGEKADRRPIDPAPIVQLRVITHDRPVRQSDVVEDSSVAPPIERKPGHGPKQPQTPGVRRGVPVTTALGDGWEDKAWYLENPYFFMYAMLCNADTDEELHLLNDGKTRYTSGSCVSCLYHLKDIDGSHQGFFVFPDLSIRVEGRYRLKLCLFETIGHSVHHCKSVYSDPFHVYTAKRFPGMEESTKLSKSFAEQGLKVRVRKHPRSRRRSSKRTKDDSEASDLEAASSRARDRSPKRARASDILPQPSLAVPQPTAPRLTRTLDSRYERPAFDRRASNASVSTDPQPPPPHPYSLRDEEEAMRVRAARSRDAVFDNALYARHTRDEGPMDPPAHMRDFADARYAEERVPRDRPPPALPSMPLRAPHEYPEYGRVEPPRDDRGRALPPAPQPAATSPHHTHPSLAGQRYAPALPNAPPSARPYREYLHAYGAPESGTYEPARGYDAYAASRPGVRYGSSLAHERRDAQMMPASATPPPPPPGSLEPSGWHVGPPSSRSHWRSGPPSPRRAAEYHVGPGEREYASRRSPVPPGLPLARGILTPPAAFVGEGSMYHRHGHGAGELARGPTVYESEVGAARPMRYLREDFGPERAGPGGRGMGGERPMLPPLSAPPPLAQRRDLGRERDAGYGATERFMPPSGHGARAPPPLASNEAELAERERERERAWERERDEAYGAREWEARRASRPYGGSRPPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHR8</accession>
    <name>W3VHR8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyoxaloxidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHR8"/>
    <dbReference type="HOGENOM" id="CLU_009630_3_0_1"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834530" evidence="2">
        <location>
            <begin position="31"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="75"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="465"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="629" mass="67107" checksum="697C27A20C590DBF" modified="2014-03-19" version="1">MAGYSKSMMALKGVVLGALLLVGTGSGVAAGKAGTMQVVGNSGVSAQMMFLGTEQKVYILDKTENNPLKVNGHPAWGVEYDINSNNIRAMEVRSNTFCAGGMTLGDGRWLVTGGNKAVTTNGADAKSGQGYGAYNGGRALRFLSPCDNQQCQWDDQASNQLNTERWYPTVEPLADGHNIILGGMRDGGFVPSQGSNNPTYEFYPIKGDGGSRNLPILQRTVPLSLYPIAYLMSSGEVFIQAGREAILWDYKKKSERALPTIPGAPRVYPASGGSALLPLSAENGYKETVLFCGGMSLGKTSNWGNEGGPTIAVSQLPASTSCEQISPMAGGASWEAVDDLPQGRSMGQFIQLPDGKLWFGNGVTTGVAGYNTNPNAPGRPVGESYGDNPSHQPLVYDPKASKGNRWKRVGSSNIGRLYHSSATLLPDSSILVAGSNPNADYNTNTKWKTEYRVERWYPEFYDAPRPSNGGLPRTFSYGGNGFSMTLPSAADAQKAKVVLVRTGFSTHGMNMGQRMIELETTRQGSKLNVAQLPPNPNLFAPGPALAFVVVNGVPSQGKMVMVGNGRIGTQPVAAKANLPGGKRDEMLEGRNSSLLERNLDHVASQLGHDDVLRRSGLHARHHKSSTDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI00</accession>
    <name>W3VI00_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI00"/>
    <dbReference type="HOGENOM" id="CLU_845021_0_0_1"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36564" checksum="0F971B9FE63976FC" modified="2014-03-19" version="1">MPKRPPGSACCLALASQAAAVSSAVAFSTHPLQIFEAHVFCNALSHSSPSRAKSSQAVPEARKNRAADRQRVRSTQFQAADTHISNSSVSQRSRAKLGREHAAEVADDRQQRPDMTVSAEDSMAEVQPMLEYLQPRTRSQRPSSPRDSRKKREQHRQPSRHPTPPARSDDPVVCALLVALAASPTGRVRTKTTKRASRVLIEKYYPRLSSVDFHQNKRVIDEVAIIPSKRLRNKIAGFTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEVSALDTTAPGSLEVDPDTKDMLRSFGFDSLPVSVTAPVTAYQAPERRGRHVPGAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI76</accession>
    <name>W3VI76_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_240833_0_0_1"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16871">
        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000026">
        <property type="entry name" value="SWI/SNF chromatin-remodeling complex subunit sol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008626">
        <property type="entry name" value="Mediator_Med15_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05397">
        <property type="entry name" value="Med15_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="539"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="777"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1080"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1154"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1447"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1561"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="240"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="409"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="801"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="883"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1080"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1120"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1241"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1277"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1295"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1453"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1488"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1561"/>
            <end position="1586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1645" mass="174046" checksum="981637A0FA401018" modified="2014-03-19" version="1">MSGFDQTHNNAFFNFNNLTPQQLNMLRQQNQMQQAVQMSQHQQPQPQPPPGSQPQQMQQHNPMMPQLGLPAGFNQQQLQALMAQQQSQLANGLMPNNQNPLMQMMRPQSMQQQQQQNANMGSTPQVGGVAGPTPTFAQLSHAIEQAKKGNLTQEQMIQLRQLITRQQAMQAQQQAAQNQNAGARPLQPGQPMVNMSVPNGQNFANALQRTPQMQAQAQMMAGLQQVRPGGPQSTPTMGSQPFLQPGQQQQQSPAQPQQQMQQQGQQQQAQQPNQQQQVGLQGPAQMSQQQQQQQQQMARGQPPQQVAGHPQSAQPQQQIMGQQPGQPGQQRPVPGRTDTATDARNQQNPLNFLRLLHQRVTDIESKLSSDLSAEERQAVQQQHAEAKRLQSALLQRLNVQNAQQFAALMQQGQQAQNPQANQAQPNQPSQPQQPQQPQPQHQQMQHPQGLGGMGTGMMGNNPAAQPQASPVIRPPNRPGSARPPQGQFGSPMLNQSGMQTQNAQQTQPHQSPQVRPSPQMGAINVGGQAGMSGLQGVPSLRPEQFMKALVDLMKKRGTPITSLPKVGGRELDLYRFYQIVQAHGGSEGAHQKGAWPAIAMSLELAPLGSPQTQALGQALATEYRNYLAPFEETWQRAMQHQYQMSMAGAGLAQGQGAGQPNPQAPAFRPPSTPQMQSQQQQPQQSQQPQPGQQPSMMPPNVPQQQPQGAQQPVRPGQPSLSDFNPPPPPMLTADHLAKLGMTQEQFNKVFLNNQLNIWRQEQLQNQQRQLNSGFQAGQAGANNMAGFGQNGMQQPAPPQQAQPQQQQQQQAQQQQTQQQAQQQMPMGWPNQVRPVMPQNAAGQPSQSQPAGFGSAMPGAQQMQNPSQLGNNAQPPQQPPQQQPQPQQQQQQAQAQMPGQPSQQSQPGQQNASGAPNASGQPQGQQGQMAGRPNNMAQARFIAVSPEQLEQARAAMQKIDQELATQRPRLPIIQNIADDERDQILDQVQKLAPIQATVTALLPAFYAMNGNLEPAKRLKIMAFMYKDQFDLLPKKQCILRLADLDKLKMQMSRCISFVRSSNPDLAARIIASLGDPSRMAAAMSSSNTNAPAAPGANTNGSANAPPSTSNAAAVPAPPAAAPADAGTNGADAAAGANADGTFDAAAAMHGIKRGLRPENLKLPPNKRAKNAFTGKAMSPSAGANESPRVAPSPAQPEDTPTPAGSTPAGKGGKKNDKPAKAGKTTVKKGKGAAGTPTSSAAEPDKKFKTSADIMAEVKREMAEAERKRREEGGGGASAGDASAGAAAAKVDSANVKAEEEAEEKRRKDSELAGRDPAGLVESTWQELLATGHANNNHLRGMNGMNGMPGDMSLLGAPSGGAGGSSGSDPKALQSLMSLLGQDSMLAGLPADGSAAVNKGSGSGDGSAPSGSAFLNGAMDSLPSADADAGLDIDLFDFIEASAAGPDAFNDTDGELGGMFGTGGLNASTQESEPPVETPELVASARLPGNSSNASSSSNSTNNSLRAKLPGALGGHGLDFGSAGPSSTSPAEMSSCDEIDLDKSPFVHRMRLDRIGLTIAPAASAAEAGKATSTSATTTTTNQADQSTGKAPDEAAVGQVELGPGSHGIIAGSGDEWWDLDHFGNTLGGSGAFGSDANADQPWAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIK0</accession>
    <name>W3VIK0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000031">
        <property type="protein sequence ID" value="ETS60637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIK0"/>
    <dbReference type="HOGENOM" id="CLU_033666_0_2_1"/>
    <dbReference type="OrthoDB" id="2553902at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF119">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="103"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="35279" checksum="98617663B4DC6340" modified="2014-03-19" version="1">MRGEHIPKSKGGRTPLLTSRQRSLLIRGIGQRLYTSATEASAYWLQHYQVRLSRYTITRVLKRAKLKLRVKRKKPLLTKRHKQRRLAFARRYQYWTVEQWKNIIWSDECKVQQLGKGFNRRYWSRQPNLNMYMPNMQGGGHSVMIWGCMTWAGLGLMVVVNGKLNSESYVSLLEEALPGSILKWKQKQALPSRDVMVFQQDNASCHSSRETQEYLREVQWNVLPWPALSPDLNPIEHVWTELKKRLSYQRYTIKTREELKTAIARIWEQIPQETVQTLISSMPRRLEAVRKARGGHTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIK9</accession>
    <name>W3VIK9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04362</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIK9"/>
    <dbReference type="HOGENOM" id="CLU_086803_0_0_1"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="46"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="210" mass="23183" checksum="FEA589E6908622C1" modified="2014-03-19" version="1">MTFNNLTLYTTSAVLILDTDGNRVIAKYYQPPHAANFLSTATPAQQNAVTATTPQLCAKNTLATLKEQRAFEKAIFDKTKRATGDIILYDSHLVLFKSSLDVIFYVVGPAAENELMLSGLLSAFYDATSMLVRHQVEKRAILENLDLVTLALDETVDDGIILETDSTTIASRVSRPRPDVNEIQINEQTIMSAYSSLKERVAQRILQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIL9</accession>
    <name>W3VIL9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIL9"/>
    <dbReference type="HOGENOM" id="CLU_074237_1_0_1"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833010" description="Large ribosomal subunit protein uL11m" evidence="6">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="7">
        <location>
            <begin position="80"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="150" mass="15598" checksum="5A1DC872627E8053" modified="2014-03-19" version="1">MSKKGGQAAAAAVSTFVKLLVPAGKASAQPPVGPALGAKGVKAMDFAKEFNAKTAHLEVGLPTPAIVKINPDRTFSFEIKTPPTSLLLKRAAGIETGAGKAGSQVAGTITMKHIYEIAKIKMQDVKGVQEEQMCKVIAGSARSMGLRIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIS8</accession>
    <name>W3VIS8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF788-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIS8"/>
    <dbReference type="HOGENOM" id="CLU_094308_2_0_1"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25680" checksum="5C0F7A1FABADE623" modified="2014-03-19" version="1">MLTPGHGTDPILGAVAVPFIPHRLRSMKGPRRLGDSIEVAHGIADEEELQARGSAKKTASGNAFLLTLLRNGFLATNTVYLLVRFWLLRSSVTKSTVFGYAVSEAIAVALWFTLQSMAAQGNDLQQSGLTQYMFDIIYVTWFVQLASLLWSKFWYLYLIIPGYAGYVIYQKILLPYLFRGQSPFASLQGLARGSNAQPEGAPQQQEAVSKRQQKLQARAAKGDPRVQVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIY4</accession>
    <name>W3VIY4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIY4"/>
    <dbReference type="HOGENOM" id="CLU_016545_0_0_1"/>
    <dbReference type="OrthoDB" id="6088208at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="431"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="668"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="861" mass="90076" checksum="A294B5C87D812DFD" modified="2014-03-19" version="1">MTVATDPSKAGGSSSQDSVLSSVPSRDSSVPRSRKVAVTTAMQPPVTSSSHASSSHASRSASGLTYSTWLVLDADDSTRPFLSRLHPRAAGPSTVPSGAVSPAARSAEKLTELTNTSTAAAAQAARKASASSNVRAQASKFDAANAEAKDGVNGLDKDRRASLQHAASHAATSAGTTGSIGRRSFMSRLRGAGGSVSSASVFQAQGQAGTEDAASVSASGSWSIVDTPAPINEEGQGASAARKVVFAYSSMATSSAVQQASGLLARSSAMLSPSPEGQIVEQVHSDRVDATSMAALAQTHRVEAIFVGSAQSSTSSDQLFAFLQALVDASSAPVKRILVEPATVRRLSTEQAAALFDAARTRRVQLSLPVRWTSMSSINVDETMQALELLQEVEGEQAQRAQSVGDGEEADVSGNFDVSLSNIPTGLSSDKLDESTELETAKAQVAQLERDLQNKDRRIAELVRQAEALAAENKAAKAASELAPIPATAAAAEETTARSNAGTSAPAPPATVSASAVAAGTSAELLKPADEQAPSTPHTPVRTPIARQLDSNAAATPMSTPVPSSSRNLAAAVGSRTSSPHGAVAAALGAAAAITGSPGSPSGGARSSGKVIATLTAELSETRTILDATRAALAMVRTQSAAYQAQADEMRGTLSRARLENDSSVGILARKDRQIVEALERARKAEAEAKELGRAGREWGTRVREVEDELGKERIKRSRAEQAYEALSSEWKSARERLRAEVDELRTSHAEQVQALAKEYDTLLAFKTRLQDHANVTIETGNTDFGAQALVKDLERVNADMQTYLTTQVQPLVDRMAMLEQRENAQIVDRITLLTDELTRIKTLMRRGDITSPDQIAPSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ28</accession>
    <name>W3VJ28_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nucleoporin protein Ndc1-Nup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04299</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ28"/>
    <dbReference type="HOGENOM" id="CLU_433439_0_0_1"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS61549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="68214" checksum="360D0917A9A30608" modified="2014-03-19" version="1">MPSSLASIPQAQLPSKYRDVVKLALQPRQTRAFVLAAITWHLCLCAALFGTVRMVVSPSTLVVSAASFGTAILPLLARRKRGCARITSAPPKTPSSRTAQLTAALAHADSGRAVTQHTAAFVVLALGYTALLTARTEGWAPQIWVESHAAFYLNERFLYLLGHSALLGAVYTVVFRCLPSPDTTALPAFDAKMLTTDARVTIKDRVVALASSRLPLALVAATLASITSVVVYAAVRVRVWSSVLLVVGSRGLLRRLLVPSFRLEFGTLEVGVRTTLFSVAAVCAVETAYVLLDVYLTHPLVALSKYARNPTRMLVDGIEEPLVFFASHAFAELARLSAQDGEVRAAVYRDVNSDATAWIQIRDRCLKLLEEQRQFIARRGVVEAAKPAAPAAAQQAPQQQSAAQPTRTIWDQLASGQSTPSSSASPAQTSRTAPTTAAAAAGAGKAPSPAPVVSIANASRLAHALVSTAWRLVPSDAKHVLFGPRRRQLLLGDSPASDAASIVGRDAQRTVGAVVALKSLLCHSLAEDAYGVVQKDIRRVLVALVELDCEIRRLGLELEQRARDIDEQLAKQQAAEPNTQAAARSEYQQQLSTAWSSSGAESVDTALTAAMREILDTFAQFDLQLGTPLEVQLAECLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJG1</accession>
    <name>W3VJG1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04157</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJG1"/>
    <dbReference type="HOGENOM" id="CLU_000315_16_1_1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001497">
        <property type="entry name" value="SNF2 family DNA-dependent ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="523"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="906"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="277"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1091" mass="119798" checksum="0DB1EE200E6110A9" modified="2014-03-19" version="1">MHHQRRSTDDPIEPATPPRAHANSATAPRIICLDSSPIVASPKAATMSAHPFRPAMNATNASAMSRTAFTAQPGSSSFRSSLQQFKYNGTDAKREIIVSDDDSSGLSDPESSADDEPKPKKRRLVRGGNSRNRSREPSEETRSRSRSPTSTADTSRMSSGGGKRENATTANGHDSSDDDVQEVAPQRPQPTTATATKPTPSPTKPAAATQQAHLPAPMSEAELKQKARRIIQIQPLLEPKRIIAALRQTRGNIDKTLQLLASRPSVVTTKTISLKPARDALPRPASASVAASDRSRQSSVAAADSRSSTPASSRAPAAAAAVPQPSKPKKRAEETIELSSDDDNSDGHDRAEREDRAAVKWFNTADANALMDTTNCNAQQADTIIALRPFAHADDVEDKLGSKAAKGVTPRLFHQCKDLMAGYYEVDEVLAKCETIGRELTDAMASWLPDASQTVSRLASPAVTASVAASAAGSREGTPASTLNLASIKKGVADKFYLEEQPRLLADGVRLKDYQLVGVNWLNLLYRKKTSCILADEMGLGKTAQVIAFFAHLKHLGIRGPHLVVAPSSVLENWDREFRFFAPSISVRKYYGSMKDRVELREELAADPELEVILTTYDMAAGGPQDHGFLRKFGRRGCGRSECKAGCDEQDCRAGGFEVCVFDEGHMLKNRKSQKYEKLLRLKTHWRLLLTGTPLQNNLQELVSLLNFIMPAYFSDAEEALAAIFKVKPGAQQNQLSKQRVDRAKKMMHPFVLRRLKDRVLTDLTTKTVRVEYCDMTPSQRRVYAQAVARTKRVAAAQASEPAATRSKTATKGAGSKESGHVLMELRKAANHPLLTRRLFDEAKIDAMARDLMKEPDYADYAFEHIKEDLRINTDAQLSFSAQTYPATRKHVLPAREWMDSGKIQALQRLIPEIQAQGDRILIFSQFTMVLDILCVCLEHMGIKYVGFTGSTQVEDRQVLVDQFTNDPSITVFLLSTKAGGLGINLIAANWVILFDQDFNPHNDKQAADRSYRMGQTKPVTVVKLLSRGTIDEDIHALGERKLELADRVSGEDDTESDEAEQKKVAQTLLARLRDAASPDVIEISDTDQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJG7</accession>
    <name>W3VJG7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_04810</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJG7"/>
    <dbReference type="HOGENOM" id="CLU_010365_7_2_1"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="330"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS60891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="629" mass="68624" checksum="D9C399727B31DDAB" modified="2014-03-19" version="1">MPSRKRSEGSVLQVLVGSVPLEGMTLERRHGSPSTAGIGLLQNTRTGDPWIGQPKYTKGIVATLSIIIAIYALATLRSRWQQSRRSYLANPSDAGPKASKSRPGPWARVVAALRVLAYRRLPSYRLGLINLRLPVLGATLAMSAFMLGFTIWTFVVQPYYRVDRSFGSPPLALRSGMMALGLMPFIYVLGSKVNFISLLTGVSHEKLQVYHQWLARFMLFLSTVHALPFIHQPLADGGVEGLRETFFSDSINTTGVIAYACLFVLSFASMTSIRERCYELFLLIHVPVAVVFLGYMFVHCQAMLTSWRYLWATAAMYMLSVFLRFAMQLRQNSFLTLSRCRIEALPCSLAKITVDSTMRWRPGQHVFVRFPGLAPLTAHPFTIVSMPAPDEQQLVSTVVLMAKARNGLTKQLYELASTAQSGPSASTLSAILDGPYGQDASIAGYDHVLLLAGGSGITFVLASLLELAWLWEQKAAATRRVHLVWSVRDEQAISWAREHLIAVHALAPPGSLQVSIFVSDPAASSRNLDLPAAWDLQWGVRPDAASLVHELASNTTSPPVPEAGGIEKTPSSPEHERACSSSTAAVVVCGPTGMVEDASNAAVRVQSDIARAKLASLHGLTLITESFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJJ1</accession>
    <name>W3VJJ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJJ1"/>
    <dbReference type="HOGENOM" id="CLU_011784_4_1_1"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="168"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="551"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="671"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="702" mass="79243" checksum="D3DB5E3BE01D3868" modified="2014-03-19" version="1">MATIKTPIAPVPTASDFLDIVLSKTQRKTPTVVHPGWKITRIRSFYMRKVMFTKDAFAEKLDAILKEFPIMDNLHPFVSSLLNVLYDKNHYKLALGQLNTAKHLIEQVSKDYIRLIKFGDSLYRCKQLKRAALGRMATIMKRQKDPLAYLEQVRQHMSRLPPIDPSTRTLLICGYPNVGKSSFINKVTRSDVDVKPYAFTTKSLFVGHMDYKYLRWQVIDTPGILDHPLEEMNTIEMQSITALAHLRAAVLYFMDLSEQCGYTVEAQVQLFNSIKPLFANKPCILAINKTDAKRLADLEPERAALVQSIIDESEGKVQLTELSTYTDEGVMETRNLACDVLLASRIESKMKGSKINAVLNRLHVAQPKSRDNVERTAYIPEAIANGSIKKYDAKDPERRKTLRDEQEENGGAGVFNIDIKRDYMLANDDWKYDHIPEIYEGKNIADFVDPDILDKLDALEREEEKLEAEGFYAESDDEGSMVDEEEEAIRSAAAAIRERQHKAKLAAQDRSMIKNQARVPRKFQERTLSQMAERMREIGVDPSSVTARAEMLAKAKGLTGKRKRSGAGDDDEEMDEDDEEASWEDDEEDDEMDTEEADTSASRKARKSNVGGRLLSSTTAPVNRSGGHVSARAGPARVSASDRQLAGLKDSEQLEKARKLRELALRPGNWHAKAGESDRAIKEKKPKWLFAGKRGKGTSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJY1</accession>
    <name>W3VJY1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(+) synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJY1"/>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="11">
        <location>
            <begin position="66"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="820" mass="90919" checksum="8B3B584967DA3534" modified="2014-03-19" version="1">MTADGGVAVWRTLKIASSESKLGSRKIKGLGCDGPCSAPPSRPGLTHLFRRLAHQDDHSTKMGLPITVSTCSLNQWALDFDGNRERILESIRLAKAAGSRLRVGPELEIPGYGCFDHFLEPDTVLHSWQVLGEILASDATHGILCDVGMPVLHRSTLYNCRLLLLDAKILHIRPKMWLANDGNYREMRYFTPWTRTNHTDDFTLPRIVADITGQHSVPFGDAVVKTRDTVLGVELCEELFTPNSPHIRQGLSGVEIFTNSSASHHELRKLYRRVELIKEATLKLGGIYLYANQQGCDGDRLYYDGCPLIAVNGSIVAQGSQFSLDDVQVISATVDLDDVRAHRSAKSRGMQAVSESIGEGCARISVDFDLGESEEFGSKTPGTATPDTSAHNRKDGRGAASDATRLYRRYFTPLSQPIEVRYHSPEEEIALGPACWLWDYLRRSRTQGYFVPLSGGIDSCATATIVFSMCRLVLAALSNPRGGESRAGASVLTTDTRAQVLSDVRRICNEKEDSTWVPATPQELCNRVFVTCYMGTENSSAETRARAKQLAADIGAYHVDLDMDVVIRAIVGLFSTVTGATPRFRVHGGTPAENLALQNIQARLRMLLAYMFAQLTPWVRGSWGGLLVLGSANVDESLRGYLTKYDCSSADINPIGGISKTDLKAFIGYAQHAFDLPILESFLTAVPTAELEPITETYVQADEADMGMTYDELSIFGRLRKNLKCGPYSMFNKLLQEWGPTLGAEKVAEKVKLFWFEYARNRHKMTTLTPSYHAEGYSPDDNRFDLRPFLYPSRFPFQFRKIDQLVARLASVSSEDQKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJZ2</accession>
    <name>W3VJZ2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJZ2"/>
    <dbReference type="HOGENOM" id="CLU_625729_0_0_1"/>
    <dbReference type="OrthoDB" id="2554028at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="440" mass="48065" checksum="BA73D7DC223C2C5A" modified="2014-03-19" version="1">MRSHTLARAVLRAAARGPASRALVRPALPTAAIAAPPASQWASAQAFSSSSSSLKKKSKKSLVVEEDFAADQESDEFAIEDDDLFGSVADAGTSASATPAAAETSRVEMVKALEDYRASLEWDVLDAGRFPSLSRFRALAGRMGTREELEQMLDIAKVYRDRVGSLGVESGRALASRAARMQLPELALNAFLDRYTYGLEYDMESLYLLQTALTKKLNRNDRAELLESAELPGAPTHETDLFGVVPSETAAVEGEEGKAEAISRKHELDMPLARAQISLIDRMTMLTTLAQTLRPNAGTYDALLLSHLPHAYITTFRLTSNRNAPTNPLLKNVFARTDALISMLTSAAHGALTHPTQEAYLMGNETLVRTRSVRLYHNLAAALSYVAMRGTDVAKRAQEDPVKTLYTYMDHLAPNQANTLIRKIEPLLQTYESKKPLANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJZ3</accession>
    <name>W3VJZ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJZ3"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000034">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="336" mass="37181" checksum="75759AF49E51A924" modified="2014-03-19" version="1">MLASARRNGAEKPASHFKLNSGASIPSVGLGTWQSPKGEVRDAVCHALKSGYRHIDCAWGYQNEDEVGEGIRLSGVPREDIWITSKLFEFHHNHVRQAVQDTLDKLGVKYLDLYLMHWNIAFVPEDVPAGQLPRDSKKDPKTGKHLLDLETTENFVGVWKELEKLVDEGIVKNIGISNFSIRRTKELLKSCRIKPVVNQVELSFTFPQPELVAWLKKNDILPQAYSPLGSTGASQASLSVVDEIAKKHGVQGANVLISWQVARGCNPLPKSVTPARIENNIKLIDLSAEELDQLEKGALAQTPKKVCDQSDLVVPAYDIFEADHPTNNDKVQAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK42</accession>
    <name>W3VK42_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK42"/>
    <dbReference type="HOGENOM" id="CLU_011106_4_1_1"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="236"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="729" mass="80420" checksum="61ADCAE8D28C2568" modified="2014-03-19" version="1">MAVVKGGPSKKNIQSTGIKRVKGENFYRDAKKAKVVKLLSKDGIASKAIRDKNGKIIQAAEFQSSEAKPGRVQPDKRWFGNTRVISQDALDHFRTSLGSRVNDPYSVLLRRNKLPMSLIQDPGQGKAPSLTTLEPYSDTFGPGAQRKRPRLDGGMSSFAELAESSEQAGRAADEKQAALEAKAAGVGLVPSDYEVGSSAQRSANGFTVDADELYEIPVTRGRSEPIYSKGQSRRIWGELYKVIDSSDVIIHVLDARDPLGTRCRSVEKHIRDDKPHKHLVFLLNKVDLVPTWVTARWVKILSKEYPTIAFHASINNSFGKGSLIQLLRQFSVLHSDKKQISVGFVGYPNTGKSSIINTLKKKKVCNVAPIPGETKVWQYITLMRRIYLIDCPGIVPVSAHDSETGTVLKGVVRVENLETPAEHIPALLSRVKPEYIRRTYNLEKWTNSEDFLGQIAKRMGKLLKGGEPDLETVAKMVLNDWIRGKIPFFVAPAEDAARAAKGKAKASAEEVEAATAAASADSAQDDEQDAAIDKLLKKKKVKGVEQPLKQIAVATKFTREDIEAGRPEDYVMERDEDEPVPELAVDEDATFDSDNEGAEDDDDDEDSEEEDGDALEDLNWDDVFQGGSGDEEEQDDEEAGDVTAKSSPGKRASAAQDDEESDEADSKHRKTKKEPRMKTSKRKAENYYTHANVKNKSRRGKPDAAEPKSKERGPKVGANGKGAKQQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK48</accession>
    <name>W3VK48_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK48"/>
    <dbReference type="HOGENOM" id="CLU_011271_2_0_1"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="483"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="935"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="957"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="973" mass="107613" checksum="E31650C5C40922C7" modified="2014-03-19" version="1">MPSSPRKGAKPSPAATTTAQSPSQPSEPSTSTSLPQLSKAHELAELIASHPERLADPDASLSQLSVSALKQLFDHAVRSEEHAVPAICSFINTIAPNSAAPDQRASRSGGKRKRGQAAPATAPVFEATPLDELIIQGMDSRQLWEQLDLKASQMSGLVERYFAQGLIREEEEDEEDEDDGSRAGPSRTRKHSDDDESSDDDDEDDSDGQEDEDDFDPEEERVKLSQLSDADLRALGIDPALREQFLAELAQEQGDDHDDDQDSDEEGSPYAGASDISDGDPTEVFYEPLKTEAEQLRRKEEQEMGMLPRLRSQVGDDDDDEDEHEQSDSGDQDDIESEEEEEEQEQSTNKRGKRARASDIPESLLQDLDRPGEPATRPAKRHPTLDDDFFSIDDLNKQLDEQDAEEEADPADESEEEDLDNQVDFYKPLAGDQDMDDDDQDDADEAAEAAAVDAADAHYADFFLPPAKAERFNKKFGKRKASARFASQDAAADEQADGHDDDASEEESQSAEPAVRVHEEPDRKRSIRFNDTIEYRRIKPRKKSADDLTPEMLRMIGASSDDVDAARDFDMDDGDDDDDDERSGQDDDDDEDMDMDEDEDEDEDEGRADMSEDESEGSQAGSDDGQGAKTARRVAGDLFADSDDEDDAQEKLSTHEKRVAALQEEIARLEDENVAKKEWTLMGEAGSRARPQDSLLEQDLEFERAAKVVPQVTEEMTESLEQLIKRRILERNFDDVIRRRELEALPFLPSRLLELSDSKSAKSLAELYEEEYQAARGGADGDEGAPMAEADAKLAKEHEDITQLYDDIFNKLDALSNAHFTPRAPKATIQTITNAPSVAIESALPATASSSTMLAPEEVYERAKHSAAIEGAKSEMTPEEKQRLHNKLRAEKRQRNDKIQDTQKALEMSGLVRAKKVNDKEEKQQALKKLVGNRGVSVIGKEPNAAGAGSGKKNKKNANGAAAKPNTANQFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK91</accession>
    <name>W3VK91_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK91"/>
    <dbReference type="HOGENOM" id="CLU_007950_0_0_1"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="320"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="610"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="720"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="766"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="806"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="846"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="972" mass="104765" checksum="1D98093F1EE40BBF" modified="2014-03-19" version="1">METRPTNLEAGPQSHQHTASSGDALDPSAALYSDGSDSGYFRSPPRHPAHFVRYLSSAPHHGSSLTDISCSGKCCWTMSRADSPVDDAVELLRSPAPNEAALIADDAVASGCYRRASLSPADSLRSVTATSPLSSPADETELHRGGRRNLLRSGTSGSITPLSATSPDPSPSPTAMTTPAPTSHAAASASTNRRATEVSTSSRTDALLVVATPMEGMFRSPSQQSAASDADGYFTARPGSPSDAGDLIALARTRSALRRERVSWSGRSYATCSSSIHPDPIGVDLAAASTTLTLDDEACYVDGDPLSPTDKAAQASRTGVDFLSCLPPELALCILFMLDSHVDLLAAAGVSKRWRAIAMDQAVWRNLFFSRPGWAIREDAPLVLQHQAELKRIEAHARRTAAREEAERLRRLQEQRKAASTSSPYLDRLSALKSWRETLHIPSFPLAGLSLASTEESSRRRGEAVSPSSVAAPMSPLRSPTAATGRFGLFLSPARPAPSTPAGARRAQEAAAGASYFAQDTPMSRQPSASSTAAGTDAPSSRRHSLDSNFAEVAEAEEFFAASLNWTRLYRDRYVLEQRWLRGHEPSRSDATVDSTTRVTKMFEPSKRFLRGHHDSVYCIRQDDGVGTGTAGKLVSGSRDRTIRVWDVESGTCKHVLQGHTASVLSLQYDDAILVSVSSDAQVFVWDFAAILATPAPSPTETAEAEALVHDKRERLHCVLRDHTSAVLDVVFSNDWIVTGSKDTTVRVWRRCDVVAREQAPVAYRKFSHTGPVNAVDLQGNRVVSASGEGSMFLWDLESGDKVHTFSGHTKGLACIVFKGNTLVSGSNDQTIRVWDTVSGACTHVLGEHHMLVRTVAYCPVRNLVVSGGYDRMIKLWHIGHPSTPAEPSNADTMRDDISAQAQDGTQDEPEGEQNGPPRDAALGTCLRDFRCHRARIFDVDFNTTRIVSASEDHLICITHFGGKGIDASLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKB2</accession>
    <name>W3VKB2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF747-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKB2"/>
    <dbReference type="HOGENOM" id="CLU_003655_1_2_1"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="696"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="850"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="887"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="972" mass="107666" checksum="FFD3867071F68C71" modified="2014-03-19" version="1">MSSYPDGSQPSSPVSPARTVPAHTTPRVHDPAPRTSQDTVRTKYSDRAPDVGPSPAPELAPVHITEAINPENATTEAETPRNGRHTLDEDEDVWEDEEDSILMDEHGNVVYEGPDYEDSASESSDDQDAHELSRAGRSYRQATQQYRKSRRALLLSGLSSFASSPSSDDLGSASPTEHATSVSPPGSIFETSASPPGSIFETSATDRENSYYQPHTAESVDTADAGGRAHSIRFTSEPPSGGELAANGDPQSDTVKGENDLRSSSEGEEDTFIDSRAIQTPRFSLADPMQTNGQLPASPVKRESAYFERPALSPRSTSTHVKPEPNTPSPGNQNGMLSPHIRPTHPGLAPSPLISESEPHDLPDAYMTPRLSLAQLQEEPRMTASPLSTQKEPEPKKETVPPANGDAHTARADDTPFSLWDYLKEEVLATDFDATQEIKWERVTNFISIPFWMEKIIMFGFVVCLDSFLYTFTILPLRFGVALWTWLTNTTRWILGGQKRYLHSSHKCDLLKMLLIVSSCVILSRITDASKMYHSVRGQDVVKLSVIFNVLEIADRLCCSFGQDLLDSLFSRSTLARRKNGKQPYLRPVGFFGLSLCYVLAHTLVLFYQLVTLNVAINSYDNALLTLLLSNQFVEIKSSVFKKFEKENVFQMTCADIVERFQLTFMLSAIGLRNLIELSGGSLEPSASPLPASFTVFPSLSLLETVLTPVLIVLASECIVDWLKHAFITKFNHIRPAVYGRFMDVLCRDLVVGGPSTRENSRKHTFVDQSPIISRRLGFAALPLACLLVRLILQIIGMIGDTSHIDECIAPVNPRISETSWIGVVARKLGAVDINNEWVRALDLFVRGSAWALTAVIAWAFLVAIKLLIGTNLVSFASHRYASMHERENEEALNSRDRAPIGTNKDERSYDKSVGRFIDRPDDDAVQIKLDGSHVLPAAKERDKAKMDSAKPKKETSLMEVSRYNMIRSRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKK7</accession>
    <name>W3VKK7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General alpha-glucoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKK7"/>
    <dbReference type="HOGENOM" id="CLU_018303_1_0_1"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="98315" checksum="824B69FDFF6322EC" modified="2014-03-19" version="1">MRTLSGAADCDVRVEVFGRRPPPPHPPSPSPSLPSTINPSRDQATVEMASTSSQPPSRSRSPPLDNDTATPSQSTLQTPDRRVQIQTPEAPASLDDLLKSPHNPALRQREPSSTLRGASPTDHRRRSGFHLWRTESEDARKARLRRALEAAEAQANAPPSWAHRIAAPLKSIPNRLGSFVHCSLYRRVSLPNGPQSGSPLSHDHQPRLTRLGLIILTLSLAGAQLAWTLELAYGTPYLLSLGLSEQSTSLVWLAGPLSGLIAQPVVGSLSDHSTSPFRRRKYMIISATLLTISTLTLAYSIPISTLLVDLFGGGLADWDPHRHRLVHSTTQAISVIAFWVLDFALNGLQAASRALILDTAPSEQQTIANAWQGRMTHTGNVLGYMCGWLDLASWQRLRWLGGGQFRRFALISLLAMISCVSVTIACIDESPADPRLLHPPARASPCASAWRKCTQTVDDVWHAIRRLPRSVRRVCLVQLFAFMGWFPFLFYSTTYVLQIAQYERALRRHDKQDALAVQQGAGESGGHASSDHDAERGSFAMLLFALVSLVSGALLPYLALAGEDSRQATPQSETPGSEPDSPLRVSTRDADWEAQQTHHLEQTDKLSRSQRLARGMRQGLTLRTFWTLASIAFALLMLVGTAWASTVQQATLVIALVGLPWSVAAWAPFAMVGEFVREAEDGTSPFEFDGDHWSPVRTRERWVRKQRRESIRQSVSRDDGALASPTSAVEARTGFKYIDEVSGRSPVREQDARDRIRASLVECAPLPHPHDDDADSLDLDAGRADHARSTGGAGTILGIHNLAIVAPQFVVAIIASLIFSAVHSSHNKIHLVLTDPLLNLAATSTQDVANPAEGTVWVLRFGGTMALLAAAATRLVPLTLSERTKRFAPTRHDIDQDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKS7</accession>
    <name>W3VKS7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diploid state maintenance protein chpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKS7"/>
    <dbReference type="HOGENOM" id="CLU_040079_1_0_1"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="324"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="404"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55488" checksum="B95FACFD45D6CAD1" modified="2014-03-19" version="1">MSHPACMRIIASRDGTHMLCHPASLRNRVFSHAPPLQAAMHGSLRSLRLELAAHHWSASRKLRLSPAARGVNALHRLQFPRTFALARPAKACAPGSRRSGMWGTPDPALQPQHAMLLYAPPIVVAAGQNHLISDSDSISAPVFLVQRTSPSATQVSQRAAPKLQNPPDDRFCSCSYHPGAPVFHEGLKSWSCCKDTNKPVMEFDQFLAIPGCNSADAHSTEKQTVPTVKNGAVVADADASAPAGSISDVHLVSKDADGKETFGKDTAATTASDIVQPLSGMSLLAAQNAAQASSTAAKAQAPKEPVEEEDPVESDANLPAGLTCKRGGCGFKFEGGSRDRSSETCNHHKGTPIFHEGSKGWSCCKRRVLDFDDFLKIEPCSTAKSGHLFVGAPKTDAGAGSEESVDCRMDHYETPNDVRLTVYAKAVDAGQSSIEFQEQGVVFSLLLPPAPGSTRPRRFRKVLTPFAPIVPAESSFNITKFKVDLVLAKHAKGQSWPCLESGDRVVGYGLTFGRDKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKU2</accession>
    <name>W3VKU2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKU2"/>
    <dbReference type="HOGENOM" id="CLU_358287_0_0_1"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="787" mass="85996" checksum="B25A77950703A92D" modified="2014-03-19" version="1">MASNGAAIGTSRPPLQSKFSESYTALLQGRQPWALDDASVDDHNSSSSSFQSRPAVARSKSAGKSNSGPRSRYFADLLCLPVETRLVADLLAAIPPEKLLDDSPHSQGARIADNVGALWREAIRVWRESDEDEVRRRNAVDTLVALSYPILTKRFSNYSFDLITIFAGGMDEADDVFTLLVDSIHDTLRGGDLARVRIPSSVRDDTDDADAHAAEARAWIDAEVQHRALQLGLLWLSCVAQTSLAAYFLRRDLFVTASAFASSPGGARYAYEGAVFLGLLATIGQGSAGGISLNVSTSNPYARRFRDWVDEQCMAKILVAAASAMDRDVQSYRQVVDDSPPSLAGSIAGLATMRWVSGFSELLGPAAPPLASDPKRKAASAASAVGADFSHLPSPTCVILLPLFLLSRSNQAFTSLILDTADQDESNGDTRARASDDSFCHLASLASYLATHASVSARSASYARISLLCLLVFLYDPRGSRNMLVDSQHAARTLERIRLCRQREPALALPRTKRTRLITAVLDVATCSLRYNLSKRIDTASYLISLRLVQRAVVLCSDERVQLEYDWHDCWSATLALASFLAARYTELRSSRDLPELIRALIATLNSILLRSDHFLPSTNEINHFVYELVRCSQTLRKTVMLLDPSSSRDAAGTPGRDADRQAAVGPTPPKLYAQVPGWKNIERVIQAVEASIADWVEQKPRSRRNQTPDINTITKLIAAIDREQLLAGATEDGYASASGPLEGANKAAAQAAMHHELEWLDRIQEQCLPEFVRHACADVLRILPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKY8</accession>
    <name>W3VKY8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKY8"/>
    <dbReference type="HOGENOM" id="CLU_048325_0_0_1"/>
    <dbReference type="OrthoDB" id="2553323at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="420" mass="46356" checksum="0273868B5C168368" modified="2014-03-19" version="1">MGAGAGAWHGPACAPLLPSPSERLVDPVLTREIGLGPTLLFSAPGRSWPLSRRSHRRGRSRAACRKERQERTEMLSPLLCASMLGAQRCFTLMLLAAMLFRSARAFEIPEALRAGRELEQVLREAQIDFPLLELSHTAPSGVRTSANELMASVQRARIAIAQHVSGIRHGADESAVDHARRLQEELMRRVETHYSAQLQGVAVDKVEWQLHRGLADGVSASKQPHFVQNILRPAPELSELIRAQDETRFGFELRRLQAVLKRINPVSAYKRWKTRRLLAQISSAPVKKAQVGTKAQSGTKSQVGTNGSPTPWNIDLLRARLSSITALRSTQVASEASLAEAEAAAQRLETVAPIKSDLKLDKPPLPKKTKPKKIKTIKRPGWDGVKAPRRWAKTMHRVAPVDSWDDIPIPGMNPVPVVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL40</accession>
    <name>W3VL40_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL40"/>
    <dbReference type="HOGENOM" id="CLU_1571312_0_0_1"/>
    <dbReference type="OrthoDB" id="10263907at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="170" mass="18800" checksum="1B5A42F6824C3B3B" modified="2014-03-19" version="1">MGNIFSSHSPSPSPSPSPAPLQARQSEPAGRVDAAGQAEAAPRDEPARRAEPATRAEPFRQAEPVAERTWPGRVALKRDVGRMLLIDISDANVTFDARFMLEYMRRSELGERPRVRHFVVHHLPRMPRDGVATTAKILLAIDRDLEQTMYLCVDNAAARAGVPDRMLPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLC9</accession>
    <name>W3VLC9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLC9"/>
    <dbReference type="HOGENOM" id="CLU_819386_0_0_1"/>
    <dbReference type="OrthoDB" id="2555305at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="309" mass="32041" checksum="D21746B9FE634E9C" modified="2014-03-19" version="1">MSFASFAPLPAPSSGASSIWARRMITKSVPTSDAEVELNVLSLLLDVPLAALDEHELATSPVALHTPASPWAPSPVSDMGFAHASPLSLEMHAAQTAVKAALDVLEEPSLSRGLRISTAMPAAAGGRGCLTAPLSPALSSPVSPAESCFSTADEGLKKKGRARMSQEKRKRLARRREREALVATLGPSELHFLPHSSHSAPVTPVHSSFTPHAFGGFPFGAAYDTAPRDGLAYDMPSPALTTASLAASSAACSTPASSPTALAPVGDANSSPPTLVVQPPSPQRHRLHGLGRPKHAWTGFAPTHLASVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLE0</accession>
    <name>W3VLE0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLE0"/>
    <dbReference type="HOGENOM" id="CLU_049363_2_0_1"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="319" mass="33634" checksum="F5ADDFB80B4C693F" modified="2014-03-19" version="1">MESTLFKVQSLFYQAAYQGCIDLALSSSSNARSSDPTTISTLLYAARSHLARSPADPASALALLKSMNSSEPHVAAVEALARFVQAHAQDDADGTSREIIALTELLDHAVVGESKGEVIRCAAATALFLDGDAEEALNTLDVGSASSSELECVALGVHMLLAIHRLDLAEAEYLAARKWADDSLLIQLIEAWIGLAKGGRSTQQAFYVYDELAQNPAAADTVNAVPSLVGKATALAANADFAGANKMLDAALKLDANHAEALANKATVAAHVEQATSGEWMDKLRSANASHPLLREYKALQQAFDQHAASFRLGASTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLJ2</accession>
    <name>W3VLJ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLJ2"/>
    <dbReference type="HOGENOM" id="CLU_061288_9_2_1"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="190" mass="20697" checksum="A32AE8C593D218E5" modified="2014-03-19" version="1">MASRGTATSSAAAFLNAGASASSPRKIGNHPRQSSSALYTAFSPKQIQGFKEAFNMIDTDSDGLITQRDMAAMLGNLGVDASPPTLQAYFRNNANAGVNFTQFLTMFGEHLAELDDQTVLMEAFECFDEKDVGKIDAHELRFWLSQVGDKMSDAEIDRLLSGPFMDKAGKTFDYKAFVEAVKMSEPAEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLK2</accession>
    <name>W3VLK2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_03477</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLK2"/>
    <dbReference type="HOGENOM" id="CLU_014015_6_0_1"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="459" mass="50761" checksum="273F324644FF6AC4" modified="2014-03-19" version="1">MSGTRATSGESDAGQYLCVQIVGRECVCDEWSAEVEMGDEEEDKMRRDVWNHGAPPLAAWKATANSAGTRHPSSNPHHAVHAQTMAARPGPSMANLSQTPSSTPGGDAKWYDTMLSHLSSQPAWPADKENAVLEPYTYLDANPGKEVRTKLIEAFNVWLKVPARKLDAICSVVRMLHTASLLMDDVEDNSDLRRGIPVAHKIYGVPQTINTANYVYFLVFSEIFRMNEGSSPAASPPLSPGEAGEAGVARATVERLVVDELINLHRGQGMDLLWRDSLICPTEEEYVEMVNNKTGGLFRIAVKLMISQSPPAHSAHFPDLIPIVNLIGLLFQILDDFMNLQSSKYAENKGFAEDFTEGKFSFPIIHSIRSSVAETEAMGTANRQILNVLKQRPTDLATKQYAVSYMRNVTRSFDYTTDVLERLHAQAHKEISRLEDQLATPNPALTHILSSLRNSWTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLN3</accession>
    <name>W3VLN3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLN3"/>
    <dbReference type="HOGENOM" id="CLU_038507_0_0_1"/>
    <dbReference type="OrthoDB" id="2555762at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF24">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833199" description="Expansin-like EG45 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="4">
        <location>
            <begin position="240"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="471" mass="48648" checksum="5ACE532A86DA88F1" modified="2014-03-19" version="1">MRATPALAFLAAFLASSAVEVLAAPQAGLGFAAVDHNGGYKHDAAIQKRIRKRQAEPECAAEASYPGSAQMPVNAASSKHHSSGHHGAKSHVVKHHNGGHHGVKHNSGHHSATGNKAPNAVPVGSVIAPPGSGPEGYGPAPGSKPDAGQGNQPSGQGSQSRPGGAGTGSSPEGYGPAPGTQPDAGAGSQPPQGAAGAPGKDGGVHCKGVLGSTTLASNGAIKHEWFDPGLVHHGPGTQFGGATGFWQGGACMLDSLPHANLPSVAMDQTFFQDGLACGTCVEIASTSASLFSNAAQWSVEEPKHGALPAGKKTIAIVSDLCPGVNQCWSGLDMHLDAWNSVTNNANGSKLPINWRFVNCKQAFAQSGSGGNSLQVHWREGANPGFFQVQIRGAHEAVVRVEMKLQGETWKVATHVDNNWWKWDSVAQDAGTKSVVFRMVDWQGQTITTDVPTKIGTDVFVQANFDRVESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM56</accession>
    <name>W3VM56_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM56"/>
    <dbReference type="HOGENOM" id="CLU_152072_2_1_1"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="80" mass="8759" checksum="F1A8F0FB46BFC842" modified="2014-03-19" version="1">MRPSPISYRAKPSFQPHVGRFTPAAVFKWAPTLALWGGAGAGAVMLFMSSVPLFKKDVLIKLPVIAPYFEDKTHPADNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMC6</accession>
    <name>W3VMC6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02452</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMC6"/>
    <dbReference type="HOGENOM" id="CLU_009902_0_1_1"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="183"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="444" mass="46378" checksum="F36422120BF36DD1" modified="2014-03-19" version="1">MSFARSAAPVRTALRTAAHQQRAFTTANAAGVKTAAADDGALTSTVTVAIKAGSRYESAPGVAHVLKNYLFKSNQKRSALRLVREAEFYGGVLSTALTKEHLLLTAEFLRGDEEFFVEVLGDVLSKSKFAAHEFNEEVLPQVQAEYAQAQSNPAVLGYDSLLQTAYRQRSLGHSLFASPASPITHRQTVDFAHAAFAKDNIAVLGSGIDSAKLSQLVSAHFGELAASASVSSTPAKYFGGEQRVAFAAPHGAENTRAAHGHFFVGFEGAGHKDAEASANLAVLRALLGGESSVKWSNGVSPLSQISESIPGARAAAFNLTFSDSGVFGAHVSAPSASVQQAASKVAQAIKNVAGGLKEEAIKAAVAKAKFERATVLENRTAAHELVSAQLLEAGSVATLENAFAALDAVKPASLSKVAEKLLKSKPTTVAVGDVHKLPYADEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VML2</accession>
    <name>W3VML2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VML2"/>
    <dbReference type="HOGENOM" id="CLU_821650_0_0_1"/>
    <dbReference type="OrthoDB" id="2554033at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="338" mass="35186" checksum="64589C020EDAF7F3" modified="2014-03-19" version="1">MASPTAIPNPEKSAHYRHKPSTAAPVDLSSEIRTSEGQRLSFSPPVSYYSRSSAPATGLRIPTGMTSTMGPSSPTNRFSVGFSPSASKKDDARMSPPQCHTRARSQTTIGAGTIASSTEPWNAGRIDPRSSALSDSAGSQSSSFVSASDLSFSRSPTSPTSSLSSSAAAGYSLGRVPSLPLGASYEQAQKRFNSGSWGQKMGWMGSMRSNALSPTLTRTSIDEGSAVGDGNANGTGPMGGLLRRFSLSGNSYRAPSTAVSSNAPVAPAFESASNAAAIPRSASPKTIPVTRDSGVCFSERMDEPKPVARGRQPSFSGNTKRKPSPMGERLLMGHFNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMP8</accession>
    <name>W3VMP8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMP8"/>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_1"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="433" mass="47485" checksum="8D66ACD5F48971CD" modified="2014-03-19" version="1">MASSLAAQGGLRVLVSGAGIAGPTLAWFLARSGARVTVLERASDLLAQGQNIDLRGTALNVVHQMGVLDAIRACNTTEKGTEFVDDRGRPFATFALGEGGGGALTTEYEILRGDLAHILYKAAESQPGVDFRFGTTIERVVENGESAVRVELSSGEEVEYDVLVLADGQWSKMRKQVFGTEGLEVVDKNCYVGYYTVPRTSEDGEMSCIHIAPRSRVVLTRPDNHGTTRASFSIVPNDAAQKEAWERASRSRDRKLQMDLLRSEFGDIGWKAPRLLREMDAADDLYFQGVQQIRLAKWYKNRVVCLGDTAYAPTPLTGMGTSLAIDGAYLLAGHLSQLQPGQHPATAFQAYDEQFRPFVSKTQAIPFFVPRILHPQAAWSRWIVQTLIATAARVSRLSWITKLFATNKPTTLSDGLVAELDAPFPSFPAFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMQ7</accession>
    <name>W3VMQ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMQ7"/>
    <dbReference type="HOGENOM" id="CLU_018702_1_1_1"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="423" mass="47294" checksum="BE5F73531087DBDE" modified="2014-03-19" version="1">MTDDGLTDDAAVEAIASAFLSAPTAKQQLLTRLMKSTDNRHQEFCLHLTRADCPDAASCQKLHFKPIVYPHTDASYGHCSYLNTCHRTASCKYLHFELDTDPPQAPFVFSTTDARHAYGPDSDEAREIGLIHPRRTLLENGFGKWVRGDGAQEEAQWIDCDLKQFDYAMLGKFDVILADPPWDIHMSLPYGTMSDDDMRAMPVPVLQDEGLLFLWVTGRAMELGRELLAHWGYTRIDELIWVKVGQTQRLIRTGRTGHHLNHTKEHCLVGAKLRCDDADVASAPIAGSSQRYVGSRAAGVPPPLPEWMHRGLNADVIVSEVRDTSRKPDELYAMIERLCPGGRKVELFGRRHNVRRGWMTLGNQLKSDHVLDATLRDRLRAFREDQAQQLAAAYSHAAAYPAAAVAPHPFGSAAHHHPVPDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMV6</accession>
    <name>W3VMV6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMV6"/>
    <dbReference type="HOGENOM" id="CLU_013608_0_0_1"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="640"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1036" mass="110986" checksum="A952C2953CE482DB" modified="2014-03-19" version="1">MVQAAPVPRGPIKSERNRAAAASGSGQHSTSSTSSAFHKKRAQGKTASHSSSSAARGGQSRPNASGPYQGSRNARQPTQEQQSNAADDDDDQSSEEDEDEETDIRSKTTLSLSAHQLPPLAALVDTLSQFRYLQRLDLSSIEPSEASADGLSTLAWLAKAVFRSKAKLEASPSKGKERAFGDNLTWLNLSSNLNLTSEACIGLEVLEELCVLNLSHCALNAIPVSISPLHNLKALVLNNNAISTLPKSFPHLPELNSLILSHNQLTSLPASLPASLPALKKLSLGHNMLRGSESLPDFSLCLALREVRLNDNAELKALPSHVRNWGKGADGKTAPGLELLELKDCGLDTWESLSTLAEADEEKEQQPRLRRKGLTQLLLKGNGVSQLDDYKERITHVHPTLRVLDNERLQPRARPADIEDAQNSTKPADRGDDRRPMKEGKRQEKREEALKKQTKAMRRQDDDDSDDDDDEAAQMAAEMRALRRGKPSEPRKEPSESDGESDDDEAAQMAAEMRALRRGKAASEPAKASKKKSSERPKPEEKTKHGKAKPVKDVSGKRSDKSGSGAADAGVQGESKPKHKRGTRAGKKGKKTDSASASTAATTDKKDKKDARDGGFFETVDAEAEKARLAPIYELSKKRAKIATGRTEVAEGVLEDVKAAPSKTQGRTVLGSFDDSTPADVASKRKKKQSSNVKDDTPAAPVNTSVAAIVDVRKKDSKKRKAGVDNASATSKKQKAAMPFALPAAAAGEAAGTAKQPYSFGAGADAWGGAARRAVEPYATPASKLRDLGRQQRSSLLLYLTSYDAASRKLMLPTVWTPRVTRRAALASASIALLLAAGGTGSRTLIPACSAQRFSHHKSSVLKAGTENACTTSSSRNASYASGGGGFESVDNPFKMDRPLNVFGRPLAQCGTNPITGFYRDGYCNTGPADGGSHTVAAVVSQKWLDYSASKGNDLRPMLSEGCSWCLCVSRWKQSLDAYKRGELAKDGVPKIKLQATHQRALDMVSIDDLKAFALDDASITPNAASQDPANGGPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMV7</accession>
    <name>W3VMV7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMV7"/>
    <dbReference type="HOGENOM" id="CLU_029283_0_0_1"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="88"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="574" mass="64117" checksum="68C7AF64C32413AA" modified="2014-03-19" version="1">MDDVSSSPTSGKARSSLFSNSIFPSPSGRRLSSSSQQASSPSSEMSASRSAGNLFQQTSMALQSFAIESVIAASAAPPRLPVAQNKEPLSLPTTTKNFRGFVQKSGPMFWFQDGVEATLMWQDTSWTLMWMAIWAVISIYPWLLLLAPSTILSVILIMTHRARYQDTMTPNIARMEVPRSPKTRAADAKTPPVGSPAEVLAYATTFPTSTGEGVVQPPLVPNPPHEGTVKYYENLRDIQNMMRMIIDGYDLLAPTVPYLNWSSYTRSLHILQLSLLTTVLMFFIAPYVPYRAVMFLAGEGAFILNHPWTKPALAGLFTRIDTSREGRKIMKMAKEGGHKLREWIEQDRLDDFVWERGWRNVEVFENERYLPDKRAASSTGVVGGWSAHNLRMGERMPWTKGPDGWTSDEVEVLPGHRIDVRCVPPLPPICFLMSFRADLVSYSPSPSCRGKNSRQVAMKLEPGWEWIPGDEWRIDWGGSWSAVGVDDQGYVYTDSSWQKPASYSYGHGGGVPDYPPSIFDVGQDTELDAIDDDAESDIRSTLPPLSAGVVDHDPKMRAETRRRRWLRRAVRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMW0</accession>
    <name>W3VMW0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ser/thr protein phosphatase 2A regulatory subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMW0"/>
    <dbReference type="HOGENOM" id="CLU_015533_2_1_1"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="274"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="281"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="359"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="559"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="65331" checksum="6A2C0A8BF902A273" modified="2014-03-19" version="1">MEADEQLFPIAILIDELKSDDVTLRLNAIHRISTIALALGPERARDELIPFLQDSLDDEDEVLLALAQELGSGFVEYLGGPTYAHLLLGPLENLAAVEESVVREKASESIVKIAEVLSESQIEEHYIPLLKRLSGGDWFTSRTSSTSLFSAVYPKSKPATQEELRKMFTALCNDDTPMVRRAAARDLGPFAKNLSKDLVVSDIIPLYRKLSSDDQDSVRLLTVQDLIAIAESLSHDESKNYLLPSIRSAVQDKSWRVRYMVADHFVKLASAVGEDVVRDELVMAFVHLLKDNEAEVRTAGAGQIPGFAKLVDQDIILARLMPCVRDLAGDNSQHVRAALGMQISGLAPLLGKEATIEHLLPLFLQLLKDEFPDVRLNIISKLEQVNEVIGIDLLSQSLLPAIVELAEDKQWRVRQAIIEYIPLLANQLGVQFFDEQLSNLCMSWLGDTVFSIREAATVNLKKLTDVFGVEWARQTIIPKVLQMGTHPNYLYRMTTIFAITTMAPSLDTSAITADVLETVLPMVTDPIPNIRFNVAKAFEVLSTVLVKTPEGREVVKAKITPALEKLQEDSDADVRFFAQKALEAANQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN51</accession>
    <name>W3VN51_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN51"/>
    <dbReference type="HOGENOM" id="CLU_053568_0_1_1"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="302" mass="32462" checksum="D34C962CB1FE620E" modified="2014-03-19" version="1">MQSAIQSVTHNLPLFIQKPAIALIGQECYTTLIYNVDLSSSHCVKYAISKALGLGIVVFGSIMKVPQILNIVNGRSARGISLSMYTLEVMAYTISLAYAVRSRLPFSTYGENLSLTLQNMVITLLVIAYTADARTGRVDPSAHSTKITVAAALMAVGSLALATPSVISSSTLTFLQACTIPISLASKVPQMAELYKDKSRGQLSSIVVFAQLLGTIARVFTTMTETDDKLLLYGFGLATLFNAVIAAQVVYYWNGDKALAEQKKRDGEKLGLHPASSSVAPSYEPFTVSTHGPAKNRGRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNJ3</accession>
    <name>W3VNJ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNJ3"/>
    <dbReference type="HOGENOM" id="CLU_014627_0_0_1"/>
    <dbReference type="OrthoDB" id="449091at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF4">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="369"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="866" mass="94386" checksum="7C063F55B4631ADA" modified="2014-03-19" version="1">MLASTTLEIGQNNTAVAVTMDKTAEFAIVPMEVSDRNATHGRSELDQRSIEWHTGDWYSYIAAFSKEDAASDRLPESHHLLHLHQGSYKLLVRPMYEIRIFGDPRNNGEQESPRMVLGIDMAARALDDVPRDEVVGIHTDPHHSNVPHVVGGWLAGWGLSFGVRNMHPTEAYTLESIDSLKQPSISVELGIPLTLSPSQTLVVPTKLNQSAPLGASITSLDLSLTLRSAAGDTITKAVSVPLIHKDAFWEASSDDQDHHAYMYSYLAPDNTVQLAAATPPRKPAATSTNQSALPPLMLTLHGAGVDVRDLFFSNSIKRQDECWSILPTGRTPWGYDWQLASFQAADAAVDAFHQHLYGLPPTMSDAERQKWQFDPHKLFIMGHSNGGQGAWYRLSRYPDRVIAGVVAAAYTKVSDYVSFAWKVGRHYADPALHGVLHSSLSMFENDLFASNLAGIDLLIKYGSADANVPPWNSKDMAMLVDGWNKRSGLQGKVRVSEVPGRPHWWDTLFSEDDVQTAIEAACTSSKNPGYAMPEAPQSFTLTVANPAEAGPKGGWQITEVEVPGRLARLQVQYTADESSEDAVAGIGHVKLHASNAKKFHVQLDALQSSTVATFGNASAVRVTLNGQTSNVDIEGARTLAFEAGPSGEWQVLASETRSIDAPAARPIGPLLRIVSTAGPMVLVVPSEGPVTEVSMWKRVAQRFAADLLLYAGINSQLVPDANSAALVEAWLKGHLGNVVAFGGPHINSYSRTIYYDWPTKHPIHFVDPESSAQFRIQGRHFYENGTALLTLAPHPELRNGLAMVVHGIGIEGISRAARLLPTRTATMIPEWIVVDSTAEWMGEGGVQAAGWYDADWGWSEGMSYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNL4</accession>
    <name>W3VNL4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNL4"/>
    <dbReference type="HOGENOM" id="CLU_016665_1_0_1"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="205"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="591" mass="65947" checksum="AE69954ED902A363" modified="2014-03-19" version="1">MLESSAVDYLHSPGYRANLTPSQTLALFKLWRRFLRLCEISSHSTDSIAQPHPRSSTDSARRTSNRRRHRATASEPASSASTSHDNLDANAGALDASAIPKDDKLKEHLRHLEESKEMQAFLLQHGGAALRREFWAIVKGEHPDAYMLRCLRARKWDVDRALAIIGATCAFRVQYNVSGIMKDAELGLTSTRGGFNIMNNGLSYIYGATAAGEPVYFIEVGSHYSSNQTADELKRGVILMQETLQMLMPPPVERKVVIFNLSNFGIRNMDWSVVLFMAKTMESFYPETLARVYVHGAPWIFKPIWSILRPLLDPVVRDKVHLTWSVDELRDHVPADHLPQSTIPGGKMDWAFKYPVPDEKENEVQQDGEKAVEMETLYRNACVEFEYATRALARAYGDAALADAKGAGIRPKFGRARGNATPADDEDWEPEGTASLRANRDILATKVRVAWLRLKPYVVGTLKYDRWRVTDAQGTIRWTYTAVDGQEEVQVLGEGTSLHVLERNLAELDAAQRVTKPQAQSSVEPTRKSNGTRAKVAATEQTQSEQEPRASTAAHTAASQPESSEAFHEPIPVHPSQMAKMQARDADGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNQ8</accession>
    <name>W3VNQ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_231217_0_0_1"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000084">
        <property type="entry name" value="Kalirin RhoGEF kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="1245"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1969"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2047"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2160"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1450"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2083"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2196"/>
            <end position="2209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2267" mass="238878" checksum="C9FD24ADB22F85B2" modified="2014-03-19" version="1">MLVRRPVSKRPANEMPNDVTLAARHNLKKAVIRLLPNKPSSPGSRPHTATLSSPRSIPSSSRPRHLEASPRAQRSLSPSSVAASPTNRRPSYGSNLLAVPGRAPGDVDADFGLGLSPTAASPDTASRHRRGSRSSILASATEATGATGATSDRESIRSSASSSRAAPSSTRRTSKSNRPDDRDRNASPVSFYSTLEAPFASPRTSRQGSLQVENTLAPFTTTSPPTAHAQAQPHRSPRTSIANASNPSHRTAPTPLAASSSTRAASDRITADKRPVPSTTTLQRATSAQHDRPPNGAVPNALTPSLSAYSWQSDKPDTPAKHHAYPQAQSLQQPRSAANEYTAPKSISTSRSASTFAQLESSSARPRSKSSASSSKDVGARSQAAKAAAAPSVPLPTTLTATTTSNAPSKLSLRSRIFGLKSSQNAPRSSSPADSGTDTPSPRSAHFPPSVHSEGSHSDSAPLDRADSLSIDRDFPSPSYSHSALGHSRDADDEMGDAFSADPRSTAQAGRKSSGATSFLRKTIRFKDKSAFLKPRPSISSLNSDSAASASQSVPPSPADPPSSSDAEDAARKAPSYKQVSGRRGAQYHKPAPDLNSPANLPHSAQHQPSSLDAKHQHRPAALLPAVTERDLQLPPEAQRQPYFNAQRRLPLRSESSSALMHDRSSGSNAQSIVPSPTAIVASSPVTTDDRVAAQNRIPRSSSLHAPTGRDHPDDLLPYRIAADRSVSSSLATQETPASPSRRPRSGSANTFAPQIQPRTTSSPAQSQTRRPVTAQGTPEVSQSPQMSAHSPARSSQRTTRPKTADSGHGYSNSLSSLRDILVVANAISEEGAYYNSPDKSAPSPSAKAAAGASPVDSKRPGLPPKNPLRKQRPSAASAADTPSVSGDSPASAHTSGVFPGPAMLTTQTSLSPTGVRPRDSIGPLSATSSSPTDFRTPTSEPTPLPSLDRHSANDYFRPRDASRPPDAPLMQIPARSPSAVSPGISGTSSPAYSTLPASQQLSRAPSTDSALGYVSRRHERAASDAASSITDLRTRSGPGASTPSLHSESSSSVRKKKDGPGSKMFAFARDLAQREGSETNATLSSSGTFRLGRSSKSKKGDVSNRPVIRRLYDGPLEAEAAAHASRQASGSSVTSPVAYAEGVSPGSSVADLANGGAHEPHTPGGFSTPGYATRLPSSGSLVRSASSSGSTARDYMLQGSNQLLTPQFMNANGTALLARSPSFVKPSWSIPQDGLSPTQKRLSKRWFILRELLDTEKAYASDLAVARDIYLARAKLGAGITTPLSPLSVRSASVFSQLASPEPPSHGKSSQPHLHHRGSVNPLSPGAPGPAARGPLPQRTLFRHASADASATAALASPHSVNQAPSSTSLASSNPSNRSSVYTVSSQSSQTSDASHFALAGHSNLGAGLPSQFSIDGGAPSPSIGLKLSQGSPLATPSPGFSPAPSTPATPSIMTPSSFPGLGDQPQSNSSDAPFSPSDVRIIFAQLEACAAFADEMVAVLESAVGTICTGPAEDAAQLLARGDVTEDSETDRVGQAFLKIMPRIEQVYSAYCSRHEASMARLQELLTTRPKTVAFVSECTQAARAYTNAWDLSSLLIKPVQRVLKYPLLLAQILESTGNQHPDAENLAAASAEIQKVADNINEVKKRKDLVEQIVSGKTARRTTSQRMQHGATKKLLRRQEKVKKAVLGPTEDLLADDGQYKSLVVQFRTLEKSVASFARRCSGWSTSVKEAHLAQLRLLDQWCRTYAVDETLAGSEAEMRLRALMHLIEQSFLSDYWTQLDSEIRTSLTPAVQRMAALFILPQAVIAKRNDREADYSRYRAEITRSGSKAVDKKLTESANAFVALHTQLMNELPQFNYGIQTLMDICIESLSRTQASYHLRVHRALISFWQSFGPEGAGDIVHNEDTDEKSMRHLNPVKIFWPLHSNIAGFAESLSIVSGVYDRSRSASVSMDSELLAVGHLSPSSNTHFSPLQSERALPDPEFSSKVPDASSMSQQIESITAAGSEELLEPMSARASPFATPPLGSRGPSFSPQLHQQALLGSPAPIGSASLHGAQSGSGAPPLRTTKSGGLIGLLRSVGSSSAMGGTIGSRKNSQSTDTMAESFGEGSESNPPTPISKDTPVLNKHEHDDAAEDVAPPTLPALSFNSGFFAQSEVFSTHPHGPDSPRVDPSADQAVDRNPALPATSRVENATSSSTATPTGTMAAVANSPAGTRASKAGHPLLEYVVGDLFRVVDGDASHLFGSSEHGATGWVERENFVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNY5</accession>
    <name>W3VNY5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNY5"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="519" mass="57613" checksum="F61D372232FBF371" modified="2014-03-19" version="1">MHRSQSNEGAASNEVYLAKLTKWWSDDEEAVVRRKLDVRIVATSFLLYLAALLDRSNVGNAKTAGMVKALHMTDAQFQWLLTIFYIAYIVFQFQVFFYKILPPRVWIAFCVLVWGIAGICQAATHNWAEMMAARFFLGVSEAGYGTGWVLYLSFFYPKNEIGLRFGVFVSAGAISAAIAGSIAYGLVNAHTDIASWRLLFLIEGIPTLIMAPVAYFALPNSIQTASFLTAREKAIAEARLFRPPPPEAIQYAATGRATTTWTSRLREQISWKQAAAAFTDPLSYITAVLFFIINVGYSSVPVYVPTLIAEMGYGSIRAQGLSAPPYVLAFFISLSACWLTDRYQVRGPVCTVLLIVGAIGYLMLACLKSTAARYVGIWLIINGLFPFIPILYMWLMANQMSESKKGLGLVIFATIGQCGPLLGTHLFPSKDQPYYVKGTATSAGLLLFGVVVSAAASFWFWNINRRRDRQHALSQVEPHEAGEEKACSVDRDPSLSEADRRKIDVLLRGEDSPYFRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP70</accession>
    <name>W3VP70_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP70"/>
    <dbReference type="HOGENOM" id="CLU_035063_0_1_1"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="2">
        <location>
            <begin position="167"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="461" mass="50862" checksum="580108255F4AE2C2" modified="2014-03-19" version="1">MSTYTRPYPYAIFTHSVGANVAGHSLLSKLRAIADAGFDGIELFQDDLDAFASSDEFRRIQEMGEASTAASSLAPLNLTPPDSPMNIDRRYSGSSSASHSSDDASTSSLPFNRPLPQDKKHFAVAGLDDDLLVRDASNELVIGLDGLPMTYNAFGTCTATAYRQELAAASYIAAFCDTLGLRIYSLQPLRDFEGWAKQQDQLLALRRARSRFEVMRALGADLLLICSNNQHAPVTVGDVERIAIDLAQLADFADRFGSVLVPLHSNSGTIERRARPIRIGYEALSWGAHVDVWSRAWQAVRLADRYNVGLILDSFNTLAREFADPCTPTGITDRCDDPYSEVMQSIRALRTVPADKIFFLQIGDARRMKQPLAPSPNADEPRPARMIWSRGNRLFPCEYKQGAFLPVREFVHAAVKEAGYQGPWSIEVFNSSLSDEGETVPTLHARRARAGLDRLVEEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPC5</accession>
    <name>W3VPC5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01827</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPC5"/>
    <dbReference type="HOGENOM" id="CLU_064620_1_1_1"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="208" mass="23395" checksum="5543BAF1DF378FAE" modified="2014-03-19" version="1">MIVLALVARGSYVLAETHDPEHDRFLPAAQTILSRIPPNSSKLSYAFEEWLFHYVSQDGMVYMAVADAETGRRIPFTFLAHVQKKFLASFEVPAEDDATDYSGLSKTLKEMVGRFNADPQAVDPIAQAKNELAGAKDIMTQNVEQILSRGERIELLMDRTDNAANQSMAFRRRAVGLRRQMWWKNTKVLALSGFSGVVLLFVLYSLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPG5</accession>
    <name>W3VPG5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPG5"/>
    <dbReference type="HOGENOM" id="CLU_006117_0_0_1"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1095" mass="117098" checksum="3E9AD59A821719FE" modified="2014-03-19" version="1">MSQVQAPLGGGYPQSPDPTLSDPRWLQQLASHPIFTPRQESSGTSTAFGDQQIAGSHARLMVVRGTDLIVAVDNEVRIASLVDAKASAATPAALASRSSSFGAMSSTSYKVLVPAQGPAIDFEIQHLSLNPTGKLLACVGASQITLLVMPRSGYTKHIDRTVACRAVPIAPYYHSAHSDAAVAKVDWHPWGESGTSLLVLTDDGLLREYDVAKDTEEPQQTASFLPIQPTPNAQRSRSRSATPNLATHNRSSSPIASRSSSNFGASGGFGLSAEDDDATTAVSFALCVNEASLARSTAFDQDDDGAWAAAASRSQGPTDWSPLTVFGLMKNGDVWAICPFLPRSAVVPAAYIHDLAKLASHHANTVESEQTSSVDTQLRYVNALLKQGSQGIAKRSRSTISNGRQTSVTPGPDSFARSRSTSTMDLDQLVDPQEAHADDSQVDMDAVQDGPIRLHPPSWSYRQDVRQGGSAKRAPRPQGPFLLRPAPVELCEERETVACDIVWTWLTDECAERTDSTTVSGVGALSIVGHDGRVDVGLLFESVQGSWDSRTTRPRNAPRRKVKTPKTNRYGLSDTEDEADELEALTLDEPEELPSLLIYETIDLGLLDTAVENGVKSHAEASDLLLDTSARNRPTFVRDPLYGDTLYVYHAFGAQCLGFATWTSKLIQALNMPSQDELDNDAHADASSATAESREQALTKVLHRGENTEVVWVVNTAAPGTGKGRNMLEMNPVTAVAILSDVYLSYAFLAVTADLQLVGVELSLRVEHDGADSPPAMAQELGLSESKLPKPYVSLLGEGPAFQAPAVFAAGSGVQGLPSHPRRAAMAGASKGEVQVTPDTLRALGKTVESYRHEIREVVSAGNAVQARLDLQVREMTRQLSKLDQIRARCAALGSGDGPSVLGERVARLASTQVALVGRIDRALQRLMDSHQPSISVYERRWFDELERIAADVGITRTSSGELKPDTRARKGIAAKADRLAHQLALLRPQMDVLAGPPANERALLGADQLRKVENLLAAQATMLAEAKAKVANLSARMAQNPARQPSVAVDADLSIASIYSSPSGVPSGLPHSSTLANLASPSSFRSRTPSSFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPG6</accession>
    <name>W3VPG6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPG6"/>
    <dbReference type="HOGENOM" id="CLU_038706_2_0_1"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="406" mass="44516" checksum="06F737CD36C315C8" modified="2014-03-19" version="1">MSKGAASASSSFPGPGMEPDTSDAPTPEYRYLVEIAQMMFVFADVVDPAPEVTRLVEDIVRSQVIEMIIQSRRLAQRRASKYLSPEDLIFLIRYDRAKVNRLRTYLSWKDVRKNAKDSGDSGGAPSGATEMDALDDQTAIEGPSMKATKMKIRLPWEISSIYSEHVLALPGADGEEEEDDDDIEAHEASMQRLKDADEATRRMTRDEYVHYSECRQASFTFRKAKKFREFINSNAYLDVKPNDDIIDILGFLAFEVVRELCLGAVAIKKALEEQQAARLRAEVQPPQKRKLERNAAASATKRPKSESGATAASDAEDSATAADRTVTATADADADADTAESTAAAAADDELCTLFSVPPSVETPLLASHIHEAFARLQRKHPAALSTGLRGSSGPGGLRRTRVFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPN1</accession>
    <name>W3VPN1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPN1"/>
    <dbReference type="HOGENOM" id="CLU_012597_0_0_1"/>
    <dbReference type="OrthoDB" id="2534600at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="901" mass="98294" checksum="37FFCBE131DCD17E" modified="2014-03-19" version="1">MDTGASETKPSVGLSESDDVGRHESAWQHATDSNHNGIHAQASSALNIERDPTSMNINGQDAGDASPAQRGMAEHDHDADDGGRHGSMANGSADLSAYRSPSGPPSASASPSRSGPTILMASRKQNSACDACRSRKVRCNRDPGEAKCNHCKAKNIECTTLYVQWATSSSKRPVKRARTSLLAASEEEKKEIPKPPEIADAAVNAQDHLLNALFQRDTEYAPIDNHVYYYNILPCNTPLSASGYTVRNILPTAYLPGPKPAAITNAELHLLDRQRREDFVNDLVETFFSVVHARLPLLNPQTFRKRYYERSKELGGPPSDVTLAIVIAWGAKFSENPLIAQDRAESAVELQKAHQQAQAALLKGESEKADQITGIKGGIEQPILTVPEELRDHGRNRIADHLTWRAQDIMDRLRVARVATLENAQACLLMESMLLHPSVYFNGNPNIAGTPIAAPHRSLLEYTNGHWYVIAIKHMIDLGIHCKEKVMTIKDPALRGETLFAWWLACMADAASALYFQRRSLISAEDYNSDPPVADADNKKVAPHPLDSIDSYLAFFGSMHDAVTFQSKVSAMHFAPRSHIEGVPFDKVAEAAELLKKWRVDHLEKVGVPLPHWPPHWDYIAAVSACTSDINYHANWICLWRLVDETGILGTDRSDATSPIHQDRLKRRSASERDVARGDAPDPDRVQAVLATIQEEALNSALRIAGLTEILRSNQYLRLDPANSLQSLEMAAHMLIRFQRSEVDIIVAGFRQYGLSYEDCFDKADVMEDLAAAYNARARTDPSFVPGSALGLAMERDASADQNGIPELAIAAAALSNAAASADTSAGYAFDPQQSGQAQTVEDPEQKHAGAPTFDAIFTASGDAVANSAIHDDPTQRSDGIAVHSNQGTAVHSDPTQPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPQ3</accession>
    <name>W3VPQ3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Other scy1 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251417_0_0_1"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="5">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="303"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="491"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1356" mass="145380" checksum="A5F2813418C17FF1" modified="2014-03-19" version="1">MPSDDEGFEITGAKGPNVRPAPKPRRSARTKLPPIPKIPSPSRESFEVAAESSSAATKRASASPAAKRKRTSRSLGSESAAEQDELEEGPKRRYKKPFTSTKAPRSSPSKTTPKEKKEQKEAKPKKLSQAALLRNKTQELQDDEHFGKLPEATIKRIAKAHVERLYLIHRFRHGTTLREEFDVFGSKGNVYKVALAQNVECSCMDFALQRRPCKHILFVYIKVLRLAGHLPVYSRVRLSNSELETIFAEARMDPVAEAMAHKGVRRAWENAVGFDPNAASSSSSESMSGEEGKRIIPEEGDMCGVCYEDLEPGSTEGLEFCLKSCGRPIHSDCLQKWFDSRGFARTCIWCRAKWDGAAEARKDPHADGYGIGVGRHGSVVDERGNVLNLAAAAAAAAALEPADEPEPADAPEPAATDATTGWDQAPNSHSTASVLVSPRLESNSTLPPSSTFHRHTLCTRHGKRRNPAMASFLSQASSYFGRTNISVNYTIDESQSPAHCGLWKIFRATRNASSLAPAAGGSSSSSASKNTVSIWTHTFNTRGQVRQRITEQLKKEASSLTRLRHPCILEVVEPLEESRNDVTFATEQVFASLSEALVSDHRQDVQLDEVEIQKGLLQVARGLEFLHTAKMVHQNLSPDSILINAKGDWKLAGFSFLTPLELPGGGGKTPWTFPDYDPSLPPAMSRNFDYMAPEYALDEKLGPENDMYSLGCVVYAVHNKGSPPFRNRNSLPNLRGNADQLATTIGSQSWSRMGSDVLDVLSSLLTRFPAARLTAASFQQARYFNSILVSTLKFMERDSFAGRTKEERVQYLKGLLKILPQFSDRLLRRKVLPAVLELMTDRSLLPFILPNVFHISKNLSSLEFTNSVLPKLKPLFAVQDPPQNMLLLLDQIEPLFVPKTAPTTFREEVTPLLYAALEAENVLVQEKALRTVPRLAEILEYAHVKEVLFPKLASLFAKTKVLSVKVSCLICFHAMVGILDKYTLTEKLVPILARIKTKEPSVMVATLAVHESMAAKVDRETLATAIIPQLWIMSMGPLLNADQFGRFMKAVREMSTRVEKEHTAHLRDVKRMQEHTDSYTADARAGGPGANGAAGGVTGIGAGGEIDFATLVGQTKTARGADKAVADDPFGLADDFGALGGGSSGLGGGAGLVASDISPAVSSTPTPIGGLTPTHTGRSAPKPSTPSLLSSSTASSTASSVPALAPPPSFVRPPLSASSSSTSSRSAAPITSATIAPVNGSWNSVLQPSSSSVAKPAAATSTASGAAGGGGAGPNYNISLPPATGTGWNPASSSLSSSLAPAIEPAPPVSIAPTPAASVGPPGWGGSVLQPNKSAAVGGAGAKSTTDAWKDFDPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPR6</accession>
    <name>W3VPR6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPR6"/>
    <dbReference type="HOGENOM" id="CLU_076902_10_1_1"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000107">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="87" mass="9634" checksum="9C6EAC50D750007D" modified="2014-03-19" version="1">MAKVSQPELKRFLDKRIAVNIQGGRKVQGTLRGFDMFLNLVVDDAIEQVHPDAGNPNVWQDGERCGTVVVRGNSVTSLEALENVKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPT3</accession>
    <name>W3VPT3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPT3"/>
    <dbReference type="HOGENOM" id="CLU_1876308_0_0_1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="136" mass="14972" checksum="287FAB2B6E564339" modified="2014-03-19" version="1">MAPPLSPPRLRPWTSVERSRWGTHDGSRVRLERPQYLDATMDARAIDGAARRLSGPVLAPRVARADPVGLMRMRSATIATVPEPRRVWPPPSSASSPELTRECLPSLPALPQLPPTPPRTSLGDYYLAHPIARSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPW8</accession>
    <name>W3VPW8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPW8"/>
    <dbReference type="HOGENOM" id="CLU_400684_0_0_1"/>
    <dbReference type="OrthoDB" id="2553876at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="727" mass="76699" checksum="BC26921DDB851D3C" modified="2014-03-19" version="1">MAQSGTNSSLPPLPRPNPSPSSLGIRQLGLLASPSTSPSPTPPIDYVHLVHHLYAPSIYTITTNVALSSALTTWLRQSQAKPAAAHAHSTVSSDRRRFAFFQAAFRSRNTADLPARSLNGGLCPVGRRIMRTHTATKVVGNDFLGNHIGELLVRQPIKRTAPTAPARHAASSNGSTVCPADTISGRRASVPTLDEQNSAAVLDEFLSLGAAPLAGCDPSSLEHGSESSVSEPSSGSSRSGSAHTDILLHLDQLTRTRVASEGAPTSPRVSFVTNFGAKPRRSGSRRAPSETGSTGYFGMTAGMSEASMSPMESAGSVVWNMPFQQSFAHAVEHHALSRGSSRQSASADVTSPAQAAEVATPTKTGSEVGVGKSQSFSAGTGPVRQRLTRAATESTLPPAAQAMQLEKSASGESGSGHSYASTGVKGHRRKPSLVPKEGDQRTFCFVDASSSETESEEAHPLPAVSSPAATPACTPEASAHSVVDTRYTSPRALSTVDEAQSTFTPALGKVHEVELRAGGQLNGACEGEGTRRVRRLRIQPNVQSRPSLLEKTMQQLARSSEQAQAANVHTTVAGSTTPPAPVSQTERFDPAAYGAEQRTFRIAPVYSAPDAPATRTEKERAPRTSQARTSDWARAQILLADNTQQDDTHVKLAKVDASLLQVQQADARGHGLLRHHTDSHSSTETTSPSLLDMRELLSPPETAVSSPDLESPPPNHKPSRRTSPLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPY7</accession>
    <name>W3VPY7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPY7"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_4_1"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="461"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="55186" checksum="CA4FFDECF0C1FD53" modified="2014-03-19" version="1">MQATTNASLFQTSYSEALGVYRSRKAVLTSGISDRSAWERYGHAIQLNPRFESAVVRDAAQLAEEGAGADGGPYRVLSLRVTKHAEGAFIWTAEAGGVVRQLDAESAQQVQVFRGAKAPIPAIDFIDTAKGEKLLVTGSWDRAIRVYRIKDAQLVAEVKDASADFVKAIHVFCSAGRTWIAAAGSDKSIMLYDATPLTTSTSGQAELKCVHKYAVHTRPINALASLTALDGTTHLYSADSMGRIIESIVSSSLRLEPVREMVGFSTAVYSIHANWTRVSEDTTGSADVWFSEVREDDDGERYRLAAQVWAASGDKSAASYMLSPSLQRPAPKSTRTMPPVGTQPPLHQASRLEHADFVKTVLPIGPLIPASYPLADDLSNAVVTAGADEHIHLHTPTSSTSAEGHWHEVTALAAWIRHPSSIQRAQSLPQAKETEVWIVSAGLDGSVRRWNLAALVKVGNPELTAPKPDSSEAGQWDQNSLPPPPTKTLKNDSQMTAEEEAELAELISDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ59</accession>
    <name>W3VQ59_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02106</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002815_0_0_1"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="527"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="687"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="840"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1193"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1384"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1465"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1705"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="906"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="974"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1084"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1195"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1265"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1545"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1641"/>
            <end position="1666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1724" mass="181849" checksum="0EF1E032164423E6" modified="2014-03-19" version="1">MASACLCSCFENYSSISTARSARAARAHPSAHASTPGTWRSRRLATVARESRPQPLRRAQFAAATAAAAQLHPDPSPRNQPARPPARLPVPFAKLLFQSSWSARDARPSVVQLQLRQHLEAARPFGFSAQMAIHPIIGLSRADALAPLPGCGSSCSWAVSALSGPPPKVAHPQLAAAASSAARPEPSRLLSIPIRPIRICRPAAAPPRRSHPLYKRKWPRQPSFNVLLLHPSARASTRQPAGSASSRTSELQAPPLAPSAIATGITNPAQGFLPRRATHADSLPASIYRANPDARNLGPRLDSSSPEHTVVSIRSLHRCPRHPLVSRLLSPSSSCFAIATSHHLRSPSASLAPAPRGPAAVALVIMEDLSADDDILSDVLVDNLEFEPAISTHKMNPNYRGHRFDRNAVSLIVRKRVVVEKDISAAIDDLSKLGIVQKYLTNKTQRQTASFQAHARRYLESYLPESGVEFALTTRYKRVMMEKAGKAHGADAVASTSAVKLEDGIPAPASKDPPADDRGKSRSKGRSSLDRAATSIGAAPAASEKADLSVLAMRTFKPGELISHCKGGLKDLTKSEDDALREEATASREIRKDSEYKGVLGPGRDFSVIRSARKGCSQLLLGPARFVNHDCNPNTEFYRMGSTMVFKVIRPIHRNEEITTFYGENYFEWANAECMCATCEARGTGAFSDPSAAAEDAPTKGADGVEIKSEDGPSSNGTPNEANGRRQSRRSSRPTGTSSALPSPSPTPSLTPSLTTVLGDEVAKDKKSKRDYLADLKLAEHGPSDDRSDPWAEGAGPKCRCLTCGATFWAPEKWWTPDECPRCERHYKIFKADWPGRVPTEGALARKAGVKRKSSAEMISDHFAASSSPARNGKERSQTPTDLKANATPKSQKKQRAAKTGAGSGTANTSSPATKPPSKASNRPAKASANSSVVQERQDEASVARSLASPKSTVTKATSLPAGTFKVASKQEDLYGLDSDGSDLTPEPESDRGDAVKMEDVDEDDDEDTGPRPAGVAGLSQSGQIHRSSSSSSTSPGPPGPKMLGKNAKTDVLAQYWGAAEGDRRARRKAASKPGPTLLSARRASQDIHIKPSERRSSFRETSTDEHGVPKPKRRLVAESASDAEDAGITPTPPRSVPPTASKHRKTSSMNDASLAQLRTKAEAQAAAADRPVTAGVVAPVPSVQSAAIAANPSPALSQAPKSSAGNMPGLATSGVERTSESNLALFWSAGVGGTRNRRQAQREPQTVLVPTVPSKRPRNPSESSRSRTPEVKKSRASSRPDAVNGDDDGSGRERSRRSRSIAVSEDTEETSKETSQDNSDADEDEADVPMRPYMFSAISKALQSNGSTDASHLVDTKGPLLPSAPLFRPPGLIRPDLATVAARSNSPLAGPPRGATGQPMRKNLRWGSGKTSMSRPLGPNGSPLGRPPTSLNGSPMATVAPRVEPAKDGASPLTAALAAVNKVQESAAAPGTLKPLPERMDASPLEPSLHQPAVDQSQALGPELISTERSPMVEAKPEAVSAGQPGDEAPATDVSATDVSAPLADGADAFGDAAASEQPKPEETPIAALTEQSSVQDAEMGVLPPEGKDVAAAAAEAADSQQRRTSGRARKAPEMAAGQIPYKGSLVKLAAQRAKEAKSGPNSPRSTGAHSPDARNQSPKSSRFMTPTAEVAGELAETAGKGELEIAAPEEVVARIEGDGSCLGAGMGAATVASSHDSPMDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQI0</accession>
    <name>W3VQI0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQI0"/>
    <dbReference type="HOGENOM" id="CLU_424649_0_0_1"/>
    <dbReference type="OrthoDB" id="3365245at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="66165" checksum="708A7D90FC7C28E2" modified="2014-03-19" version="1">MIRPATPGTLLTLVAAILLGLVTISTPIIKSIYFLEATIGGSGSQNGQVARFGTLGYCIGDTCSNSMLGYSFDPNQLLGIEVISGRYTTAVIKGLTYTLILHPIALAFAAVSVLLGLISHCRELSTNCFGTFVTGIGAFITLVAFGLDLALFIIAKKRINSINGASAELGMAIWMTLAAWILMFLAGCAFSCGICSRRKRNRVKDSHLPPDTYGARPAAPMQDRYAEQMRMDALDAEADRKRRQATLDRNRRDDLPKFAEYETEHEVPLKNDYDDGAYHNGASQHQPGLAYSTNSNIARAGAAGAGLAASGSVINGVGQGYGRRQAQPSRTEDFSSSPPMLNNSAGYGAHNLQAQRQASITSPTHTEPTYVPGVGPQPYRDGLDSQGHGSSLTPAPRSYPQIASPPPANDCAQQSQYPSQHQQQQQYDSYGNVVPSAMPVPGGSQFSQSGARRQPTGDYGHPTEYSGATFGPSSGFHEGGSRMRGPRDLPSIPQHETAEPQEIVYDHTGSAADRRQGTVDDGFGLASNAHGSHQQHEPAGYDNYASSAYEHQSQSQQYHSYHPSSAGANDGAAREGTSAAQYGDGSQYHDYQSSVGPPGYESVAGGSAAYQHNHYPREKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR54</accession>
    <name>W3VR54_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PaG_03023</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR54"/>
    <dbReference type="HOGENOM" id="CLU_030200_2_0_1"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833499" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="187"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ETS63236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="475" mass="49033" checksum="070B0953F08BE786" modified="2014-03-19" version="1">MVKFSLAAAVPLALAAVAAAKPDFERRQAASGSGTRSSASGTASAAGAAAPTSTFTGTLPASVSSLLAGVSSGPGVTTSTTSLFTTYAAGAKNPQVTGAPGLPDVNTIAPSSFPALDVIPPTDSAQVQRWISQIDWSKVPNVTTTVDSASCSGNPTNLAQAGANGNCWWTCGQCTRSTDITTCPDVNTWGLSYDDGPSPYTPTLLQYLNQNNLKSTFFVVGSRVISRPQMLQTEFQQGHQISVHTWSHHALTTLTNEQIVAELGWSKEVIRSVIGVTPNTMRPPYGDIDDRVRAISLQMGLTPIIWTTPPGGNPYDTNDWKIAAGVVSPAEVVYNFESIIKNASSLSTGYIVLAHDLYQQAVDIAVNIVLPAAQQMSPKQNLMPIVQCLKKPASDAYVETYANSSGSLPNEVGTSGTHSLTATQAAAGSLATATGSSSGSGSGSGSSGASMGSVPSFVLPTAVLGLVMLSFGLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR76</accession>
    <name>W3VR76_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="7">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02321</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR76"/>
    <dbReference type="HOGENOM" id="CLU_018705_3_0_1"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="10">
        <location>
            <begin position="201"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="9">
        <location>
            <begin position="483"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="692" mass="77108" checksum="637CA1D5623EC76B" modified="2014-03-19" version="1">MDPTLKLLTLINVSAARPGKRQRASNLTHYDKITRKAVAAQQATASTSTAASASASPSKRSKAASTSSASSSQAQGTDELVGEVSDDGDDHEASPAVTKHKQAKQPVAFDAHFGSDGPHAKAIAKLPESVKSLSWTSSRSALPSLPTNTAVSRPDLPDFDTQAYPGQPQVKVLDAFNAYAAKKYSEPTPLHKALATTLGSYTDFCDANVALRDRQQYREALAMHAMSHVAKTRRRVLKNNERLAKLAAAATSTDADELDLRDQGFTRPKVLILLPFRNSALQWVDLVTKFSLCAQVDNKARFAKEFNLPPGAVDKLADPAVASKYPEDHIANFAGNIDDSFKLGLKVTRKSLKLFSGFYDSDVIIASPLGLRLGIEKDRGDSDFLSSIEMLIVDQTDVISMQNWDHLEFVLERLNHIPRQSRDTDFSRVKQWYLDNRAPMMRQSILLSAHDFPALRSVYNHTLTNVAGKVRTLSHTSEAQAQMTRVVSGVRQTFTRFEAANVHAEPDLRFQHFTTKTLAQLSKSAVSSSHTLIVVPSYFDFVRLDDFLRAHNEQRRSGETANLSYTSISEYSTPKDIRRAREAFFSGKKRFLLLTERAHFYRRFKLRGVKTVVFYQLPQNPSFFAEFLEFPFITKRDLAKPSDDDEDDETDPNDVAAYVVYSRYDLIALEHVVGSQQAANMISQDKATWKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRA5</accession>
    <name>W3VRA5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01334</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRA5"/>
    <dbReference type="HOGENOM" id="CLU_041037_1_0_1"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="239"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="347" mass="38587" checksum="BCA32DB10EED21F6" modified="2014-03-19" version="1">MPSTQETRSRAGPSSGSPTRPHKRAVEEDFTYNARQDVNDRRAVRSEYRALIAEADESKRDQTLKPRALLELIHKADELHTRVVAPSESVLDTKTLASMSEMGARMAKKMKLNADAFDTHELMSRLARFLGGQAAPLRPANDDSDDEEDLEQWKWDKLGRTASAVSRRAVTLDFMLGPLETQPKQRRTGVVRRSDDAPAQRTAPRALGQHDLQQTDGKESTSQIFKVAQLLKQQGDAGVCLFRFAVDPHSFVNTVENFFHVSFLIKENKASLHTDEAGNAILATAQPPSGEDEGEEEEMRSKQFIMEIDWATYLDAIQLYGLTTSIIPTRPNRVDPLSGLAALSNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRK2</accession>
    <name>W3VRK2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRK2"/>
    <dbReference type="HOGENOM" id="CLU_586588_0_0_1"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833522" evidence="2">
        <location>
            <begin position="18"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="555" mass="61556" checksum="7656E67C184C453A" modified="2014-03-19" version="1">MRAVLLGVFHLLSVALAAPGFERHSAFKALHPDSFSESANLTARPFDKNYHLAKEASGHDCYASIYYGVKSGCSVESDMSPHERMLASVQLTLCDLQASSQSVPWECQSPDHDMQAIGLASCVEVPARDPADVFRAAAVERHRTAVEENVELSRLWQQHAHDSAEAVKEESLARHDWMRQASQLQDQVREVLLVSRRGDKALHVHSARLTQIMRCIAKQNVLSDMTNNQEKYSNEAKQVLQLMRQAETGLEETARSLLRSHTEAHLQHLEGLQQSLEEAMSRYELRFEATAERISSDASRSIETRLASPLGTMQDLVGVLDVQTTSLGHSVQEERDLLSALGELHRQIEMQHQAHDAQLGAGIAALQSVQSDLHRLGTAMNATHDSVAAMLVSQTPGTRWFSVAFALERIVLWAFRAVEGTVGLDTESWAGQWCRWLLLVWPLSLKVRAWMQACAPVCKVLVSGLVCISMLIKAAVRPYSFATVSMLLGIFALAHNNAHFVLLQAHLGTSRHATKVKDAHMDDKHSVRVAVGRPSKGGRRDRTLRPSRIHCPSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRP0</accession>
    <name>W3VRP0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01746</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRP0"/>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="901"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1035"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="104"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="655"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="671"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1128" mass="121113" checksum="9D74E84229014FB9" modified="2014-03-19" version="1">MVHGNGCNSAPAQGSAQPAVLAGDQARATSDAEEPPCSGYSPHPPLHSHQQHHLQPHHVASEKAQLDEPRVAVVDIQLDSDRHSTSSTRSSRSSTVAATVDLHQPHSLEPDEVIAQFQSNTTTGLAADQAAARLAEHGPNQLKETNRVSATSILIRQMANALTLVLLAAMALSFGVKDWVEGGVVTAVIVTNVLIGFIQEYKAERTMASLRTLSSPSANVLRDSTIRQLPSTELVPGDIVHFRAGDLVPADVRLVTISNLEIDEAPLTGESVPAIKTTGALTRPHLGPADRTNLAYAGTTVTKGRAVGIVVATGMHTQIGQIATALAKKGNKDDEERPWYKRAWDATATFLGVREGTPLQIKLNKFAYVLLFLAIICAIIVFGVAEFDINNEVILYAIALGIGVIPESLVAVLTITFSVGAKRMAESNVVVRRLDALEALGGVTDICSDKTGTLTQGKMVVRQGWSFASGQQQGFHVEQSGATAFEPKGRVLLPASEKDAEPTAVEHDQIPDAVRQLATAASLCNIAEIEQAEDGTWTARGDPTEIALQVFATKLQLSRDSLTQGDHPGYKHEQEFPFDSTLKRMTSVYRRTVIDTPDHLFLMKGAVEQVLACCSEMDEAARKSILDQVESMATQGLRVLAFAERSMDDVQYKDENARTRAASQDDESDESGTINTTEKKLTSNTETVNGLSRAAAEQDFRFIGLLGIYDPPRAETRAAVEACKRAGIVVHMLTGDHPATAHAIAREVAIVDGTEGAAAVMTAAQFDGLTDAEIDALPDLPLVVARCSPATKVRMIAAGKRRGRYLAMTGDGINDAPSLKQAPVGIGMGTGTDVAKDSSDLVLTDDRFDSIVKGIREGRAIFDNIQRFLIGLLVANVAEVLLLLCGLGVRDADEESVFPLAPVGILWVNMVTASLPAIGLGLEPGESDIMERPPHDLRAGVLSRAVVVDTLVYGVSMGITCLVAFLLMIYPIGGGNIAIDCNHSSAATCEPIFQARSAVFTALTLQLLLICWELISMEKSFFSMSPAKHLWKNPMLLWSVVFGVATIPIALYVPKFNTDVFRHAPMGGAGWGIAIAMTVAFIAIVETWKALARRGRWPWLARISGGQRGLERRLAKKRVQEEKTSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRP9</accession>
    <name>W3VRP9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRP9"/>
    <dbReference type="HOGENOM" id="CLU_288372_0_0_1"/>
    <dbReference type="OrthoDB" id="2555595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1066" mass="114085" checksum="17A4C708824BE7E9" modified="2014-03-19" version="1">MSLRSDSVYRVDLGERPSSAPADDKSKDHGPSSPPKVLQIRLTEQALQQLASAYTSSGSAKSQIRLNFDAAEPELVVGSVSIPLHASVPAASSQSRPPAHGFSPAPSSAAPHELYRLSHDESTLTRVGTIAAKLSVKPTRDVSAVAQRLKQQKEEEELRKEQRRQALIQGSSPNLSVASSNSKSSANKTLAAARASSSSAFFSSSPLSRSSSLTNVTAQRRQTGLLPPAAVSRAQSREVSPGARSSLPTTTHPKVQGASYESGLSVSRTARATTDSPQTSSVAQMRSSSAAHSSSHRSSGTGGSSLSTQEEGHVSDDGQARRADLTSSPASVSSDVAGGAAKKSSKLTTRQRLAKATKAGSRLLAMSERKPTPELRATPSTFARTSASVAPSTQSSAQSSRSTPIDHVLSTVPKSEPSQRATKPKESVVNASATKMGSDRQEAARQDRSQTATYLAKTKEIASSSRSRAEAAQKTETSSKRTALQESAKEPPKRERTTSVEQSSISFKTERPGATTTSVKAGAATSRSPEKVARAAVPVVTMRRARPPPVDDPKSGSPRATSQTGSSAKAAAPAIESVREQRPRARSDSRTQTEIDTRAGPSSSPPSKQANTKKRVDESPDAAQRKRRRTNDFAPPSDQPTRYRERRLSASPEPMSRRADIDMIRRRDESATPSVRPTEASTGQTSIREHVPPSASMPSFASVGHRLRSVPEAGERNSRNAKVDDYRDRRRDRGSDEHDRGTDASRDRGKSYYRETEEKSRGRSGAPDAHGSSSRGPSNGSNAVKSPSGSGERSIKGVGPGAAHWSEPWLDVRSRADWHRLAQRFAKTQQEYLASRGQLEAESERLDRELELASAEEQAASQPMGLRSQTSAHQSLLFSPHAHSVSKMTRHGSTGESDELDVDMLDAERETSVNTAHNAAGPQRRESLASRRREPREDGEESPEEGEMRSSDDEAGQPRATKGSISAEGGARAAGAELETLLREASRSESPDNIAWRAQPPGVAAAADASNVDERARSRAVASDRPLSYADLADRVHQLAELHGSLSRMHRVLVDFKAKRLADTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRW2</accession>
    <name>W3VRW2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_01231</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRW2"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000013">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="48"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="248"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS64378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="465" mass="52036" checksum="D7E73220D3345CBE" modified="2014-03-19" version="1">MRELITFACGQAGNQISSAFWQCILNEHGLDGDGRYIGSNEDEQLAKVGVFFEPSGQEGKYVPRSIQVDLEPGTMDTIRSGPLGKLFRPDNYINGESGAGNNFSKGYYTEGAELMDQVLDVARKEAEKTDMLQGFQLVHSLGGGTGSGLGTNLLSKLREEFPDRMLATWSVLPSPKVSDTVVEPYNATLSFHQLVENSDMTFCLDNEALYDICQRTLRTKNPTYADLNSIISFAMSGCSTTLRFPGQLNSDLRKMGVNLVPFPRLHFFTTGFAPLVAPGSKAYQSLKTSELIAQGYDPKNIMAAIDPRHGKYLTVAAIFRGNVNARDVENEMYNLREKNPAGFVEWIPNNVLTSLCDIAPPQLKMSATFIANTTSIQELFKRTHDQFSLMFRRKAFLHWYTGEGMDEMEFTEAESNLMDLIAEYQQYESAGVDEVDEELYEQEYQDQVDGQQEYADDSVQYADEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRW5</accession>
    <name>W3VRW5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRW5"/>
    <dbReference type="HOGENOM" id="CLU_013364_5_2_1"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="160"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="509"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="648" mass="72114" checksum="E869A190679C1367" modified="2014-03-19" version="1">MQPKMADEKHALLPEVATQPSARDGGGGLSWKAKLAFAALGALGWCQLDAALQQGRIVKHGHRHHSDWGSFPHKDDPFHFLPCTNATVPPGLDEAHPLEAWARLYDPNPNHWSRGNSSQSLYLCGWLDVPLDYTNASDDRIARLAVTKLQHAPKRSKRTMVVEPGGPGGSGTSLVWRKAEQFARKYTDDTFDVLGWDPRGVNVSQPSISCFPYDADRDRWSLLTTRFHREVDPRDAMLKADAMNQAIFEACKRKYGDVAGMLTTAFVARDLDEIRKALAEDRLNGYFISYGTGIGQTYVNMFPHAVGRLMLDGTEYVRDQRRIGGFGWAALDNITAAFQDGLLGECVDAGPDRCKLAQSLPGSSSLPTRSDLITAMDGLFGRLVERPLAGHTEASGPMIISYTQLISLIYGALYNPFGWDALAAGLHELLQGNTSMIAQMLDSWEYNPSMPVAKHSSDELGMLVICSDQYDSPLPPGYDVETNGERWYLELWKHMVEQSEIGGNGRFLDILPCRQWNATFGAPKEVYRGDLDHDLSAPVLLIAEAYDPATPLRNGRRLLREMGKNARLIAHHGYGHSSRDTSTCTDTIMRNYMLHGTLPDQQETQCHADGQPYRYTDAKSSAQLLHEWKISMAETQLLRGSSPRRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS93</accession>
    <name>W3VS93_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_01970</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 13"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS93"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000157">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="253"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="596"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS63666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="674" mass="74577" checksum="CFFC36B0AB04678C" modified="2014-03-19" version="1">MFDTTSPNHLNHLNGETLPLPSQVSISEMVGGLAMPAFGLQISGAAVRVALASGVGLAFSLLVDGAPRAVFGVGFGREEGALEPRHTEKFSLDSATPDVQGCAAVGLWIVSGSTLQHKTLFQARLGACQACFGVMRSELPSTAMQVGTLDGRPKGTRREFGGAAAPRTAPNRTTNSGICDPPTCLRPLYTTLLHTTILYTTSQRPNGLSFRLICFFAHILVDIHPLHMSAFQSTPQRTPYNVLNQTFLIDNAYEITKDLGQGAYGCVAAATHRGTGESVAIKKITNVFTKKILTKRALREIKLLRHFRGHKNITCLYDMDIIDPVGFNEVYLYEELMEADLHAIIRSGQPLSDAHFQSFIYQTLCGLKYIHSASVLHRDLKPGNLLVNADCELKICDFGLARGFETDPELAKQAGAGGFMTEYVATRWYRAPEIMLSFQNYTTAIDIWSVGCILAELLGGRPIFKGRDYVDQLNQILHYLGTPSEETLRRVGSPRAQDYIRSLPYQPRIPFQRLYPQANPLALDLLERMLEFDPAKRISCEEALQHPYLAVWHDPADEPVCPRKFDFGFEAVDEVEGMKTLILDEVRSFRTEVRRQARMMQQPKRQESLPIPTREDIQRSSPTDADNPGYALLGASTGIIHGASNSEHASGMLDNACVMEDPAESFERELTQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSR7</accession>
    <name>W3VSR7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01068</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSR7"/>
    <dbReference type="HOGENOM" id="CLU_025144_1_3_1"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000031">
        <property type="entry name" value="Chromosome 12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="449" mass="49061" checksum="2098DD106852AB12" modified="2014-03-19" version="1">MRAIVRTRVLIKALHTPTSLSTSRHLCTTTPCHESPATRPRTSAGPCAPPPTPAAAGATPPPNFGGLGTTQLSPDIMLRCTIFDSTGSTTSTSGVFKKSRLCSEHGLEPRDLRKIDSRVPNLVPTILARRGGILVNILHIRAMVKRDKVLLFDSYGSTDSQLHSAFVYNLQHNLRPHHQSGSGLAYEFRALESILVSVLDALRIELGVVRGWTSGVLEELDDDVDREKLRTLLQVSRKLNAFLSRAKAVKNAVVEVLENDQDMQLMYLSSTPTIDSEGMDQLELLLESFDKQVEEVVAETTQLQSDMSNTQEVVELILDNNRNKLLALDLKTSIATMGISAGTLWAGLFGMNLKSHMEELDWAFAGVSGVAFGAVLLTAGIGLRRLERLRKVGLGQGPVKRRKDVWATHWPETPMPTDIVQPVPTPAPSAPPLGLGLGAKWDAPKRVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSW6</accession>
    <name>W3VSW6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSW6"/>
    <dbReference type="HOGENOM" id="CLU_029959_0_0_1"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="604" mass="63068" checksum="CD04B994D5201643" modified="2014-03-19" version="1">MLASKQESAPAQLLPKAESPAANIFWPSASNDHHDARHSFFWDASNFSSHLNAVTESDLKAGATPKTVSERLLDHIPERFGADLFIELNPQSLDKGVAQPSSPPTATTGSGSLIFSSTASGSACDSSPAMSASSNYHFETPSLHQVSALAASFSTSSPSIGSVGNADASSVKTSPSQHNQAWHKDAAGATGTHQPYGAGQNQYEEHDYQGHGVHPGMSQYFHRASISGPLMASASQAERYEETPAPAPPRLHGLAAWENASGSARPHTADGMFGQFGVVSMSAPSHDSSTDGSAVPSMAGAQSRPYTPGGDSAHLGNYYQNRRMSMPDPSSGGSAGTGKVFSYMAPTNEGSMMSSGSHVGMPSHGYGGHYFGSGGGYSGASKKRPRRRYDEIERLYPCSWAGCTKSYGTLNHLNAHVAMQKHGPKRSPSEFKDMRKAWRKQKKEEEQRRQSRQLSLGDQALRSSFSGSAYADMSAGQSELLGGSSGAASALPIAPPPALSGFGGQHSGSAVYGSAQLPAPMAHLSRYSMSSVSATPATDQPAYLNGAPVDSTAAASTQSSASLGTHAPPLQYPADTRLPYSSASHAGNAYSNFGAYLSAHRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSZ4</accession>
    <name>W3VSZ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSZ4"/>
    <dbReference type="HOGENOM" id="CLU_320068_0_0_1"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="871"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="786"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="908" mass="101770" checksum="72D8DD1239F0B757" modified="2014-03-19" version="1">MDEQGIQLADQQREEHEVELILGALPSLWHNTQNVLRDLGYQQAPAPEADDGPQLGQPNDGPAAWRSDDKAAAAATSHSGSDEDGDEKVCRMCFSSEAELADDGSSLGRLIRPCYCDGSMRYVHDTCLDQWRRKAEASEAARVCGQCHARYRFRRRPHANLMAFVQASQMLRILVCVLAIFILSVAFGMVALLSLKTVALLGSTPLGFVRDAALRRVHVNSMPWNITLQPDKARAEVWIPAETWKHSASTSGMPRLDEEFYSKIDLEVFARVRQEQLLNPVYWKRVQRLPSSYRANYTDAMIVRAKLRSGEDVSEELERISRGLPLFPSKPTKHSAGEAGVAQDGAHPSLPVPERESANISSPSSQTPFNLTPSLRERLVGSDFKFKFGIPFLSSHRKESDADTAGHEDKFDVWQRQNMTIKFDYEELSSFILDEPSEHVLVRSLPEWLGFARYVPYCVVLALVDRFYFLASVFRPWWSSIARSALQLALLLLESHRELLWCASKAAVAALIAYVDVEFEPVRFNPDNAVIIGPPRTQRRRAAAMVREVMVVGADTVFGPMWLNWWGGYSLAVYMRPRQFMTTERVEMTQLAAVFAPNLTVLLDAIVSGLASFSTRAERFKTTTDRWTRADWVHHDYSASEGYRRMIATLLGDEQASKATLHDLWLEAGTKRLLPGRTKPLQMALMPKLSVWKTAFLLGCLVTTALALVVATKMAWDSTISHFARQAWRSLVSIWQLALHSGDSMRVAWRQTVSSVLFIARWTLGRARRLASQLVRSVKSAVRSVRSVRSSQESHSGTEASDRQDPSSSSTQRTDADGAAEQAPRAEAVPEPLLNDPFLQAGHMGVFGAILGHVASIYGCIHAFVFTMRFILVYLPFEPFVILYSLLQQLIQVDVANTEVLDREDVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT07</accession>
    <name>W3VT07_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT07"/>
    <dbReference type="HOGENOM" id="CLU_105624_0_0_1"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14217" checksum="55B01D1460629B06" modified="2014-03-19" version="1">MAVTKTTKASAKQGKTAHKFFIDFSGPANDGILDAAAFEKYLHDRIKVDGKAGNLGDNVTITREGEGKIWVNTNVAFSKRYLKYLTKKHLRKQQLRDWLRVVATSKQGYEIKFFNVSYDQEAEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT20</accession>
    <name>W3VT20_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">H13-prov protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT20"/>
    <dbReference type="HOGENOM" id="CLU_023799_0_2_1"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="423" mass="46209" checksum="5FF6F5F595768758" modified="2014-03-19" version="1">MAGDRDLLIAYAVLMSGALAPIYFGSFASLKTPKTTRELIKAARKKRKGGDDSDSDSDSDSDSDSDSDSDSDDDVLDRVTSSDAMWFPIMGSAVLFSLFLVFKYLDKRYVNLLLSFYFGFVGCLALSQALVSTSRGVVGGKVWKKLPSFRLQLDQRGQGRVFKLSFTTVDVGLLAVSAVLVGVYLVTKNWIISNLLALSLSLNAIALMSLDSFRTGAIMLGGLFVYDIFWVFATPVMVSVARNFDAPIKIVWPKNILEAVWALRAHETLPKLQFTMLGLGDIVIPGIFVALALRYDQLVASEAKPSVGFTKTYTRFDKPYFRATLAGYVAGLATTMGVMHFFKAAQPALLYLSPACTGAVFLTAALRGELKQVWNWTDGEDEEADKDDQKSKSESKSKGSKAAKTSRPATRRSSRRSSAAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTB1</accession>
    <name>W3VTB1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTB1"/>
    <dbReference type="HOGENOM" id="CLU_034763_2_0_1"/>
    <dbReference type="OrthoDB" id="1743579at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834857" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="128"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="405" mass="42987" checksum="BAC6105E74E9A7CA" modified="2014-03-19" version="1">MVAGKVFSVLPLLGLALGASIRLDARQSDGSSNSSSTAGPYGLSNADCSNVTLSVPINITLTNFTGVDNTYSNQSYITKQVIEFTQAQANWTSEHVSNTTFALNRTFSIAGTYCKPRQGGDNDVLINLVHGIGFDSSYWDFAFSPEYSVVKVAASYGYATFRYDRIGTGKSETPVGGFQVARAQTEVAILQGVLGQLRNSTTVGGKQHDKIVGVGHSYGSVQTQAVTAQSPQLLDAAILTGFTTNSSNLGGYLTAGSYSIANRIFPDRLGDKPDTWLVTGSNASDITGFFFPPNYAQEAFDLARATEQPVTLGSLFTVGDVGGVAQNFTGPVQVVNGANDFIFCSSNCWAGPNGTDIPSGVKMLYPAASNFTSYIAEKTGHGITAHYSQPEVAREIVTWIQSQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTG1</accession>
    <name>W3VTG1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTG1"/>
    <dbReference type="HOGENOM" id="CLU_015682_0_0_1"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="786" mass="83927" checksum="4F6DA89E5070704B" modified="2014-03-19" version="1">MSSMSSIPHEELPILEALINIRNRLTALKKDSSEFIRSHDVQLLYQQVIKQVTRLNAVRDEQQANAQSSSTASSTSDHHDAPDQADTNGQDDSPVLQHNRVDTTLNDVFSLLSLFFLTIGRSRESPATFSQLSCMKQLLDHLQESGIYTEADLQPFGARLSELREIIRRDGDCGRHPPQLTKLMTRKLEVCEKTVRKLEGSLKVLSVELVPIHQKIISIRRQLAAAAAKPKPARAEIKQLQEELRKIDAKRVDGKFLGPGGSSVPAGQAILVGLLEECFEICHDMTVRNDEVPMTLQPIYDRLVEIKSQLEHLVLTHRWTLRETDLWNYQVTLKEIDRLRVNGKFVDSEGKQPEGQLVLLYLLRRCYGLIYRLVASSEPISEELMPISNKLSTVSKCLKEVSKYGGPFTMRDLYPYRLALHQIDNMRSKVLDKDGNDTGVRKWLGRDGSVPEGQAILRAQYEEVEQTIEEMLNREDDDDDDDEEDVWDGDSTSSAELSGTESAASDSEVEGEGASADMVRQALMARGGPMIGMAPPDGPATQPNSAAVSRHASSASSLAGRDSGFGGGLAPITPLSTAQTVTPGAGHGSIASSSASTLRAAPGAEAVAIPSDRAGTASQASPAVASPVGAAAGSPASVSVADTEAEAATAAASAASASSSTPSAVPSTASLLRSQKIGRDFRDGVGDLTGLSSRSPPVGVADGRTASLQSQIQASSTPPDTLERLPAGAAPLAVPTPGILEEQKRTGPGVGTQVDALAAGFQETSINDVLSSSAGTTATNTTTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTH2</accession>
    <name>W3VTH2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002523_2_0_1"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="10">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="462"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="631"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1246"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="98"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="207"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="308"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1503" mass="161941" checksum="74B6045CA08605DF" modified="2014-03-19" version="1">MAAPRTPSAAPPPIHLHSRVKVSNLGHGEVLFVGQTSFAAGVWVGIALDHPNGKNNGSVQGKRYFECDDGYGVFVRSSQVHVLSPEEEMHSVDDEPVAAPAPAPRAARPSAAATPSSAAAARLSPRKNPAATPARPAASRSSLAPGATPASAVRRTSAVSSASASSSASSSRPPTAAGAAARLGSPVKSTTGMRSPVKSAGIDPRSGRSSVSSTSVRSTTKSALASRTGSPSTPAAAAARTVRPSIGASSAATPAARTAAGLTRTTATARTPAASTSSAAAKPQTPSAARAGLRPVPASRPSMLSAGARTATSSPSVTSAARIAAARSATASAPISRTASAAGTASRTGSALGPSRLGPRSSAGSAVSSGRTSASQRLLDEEDAVLYNDDLEDGDANLLVSDPLLGGEDMHASHDDDIGADEADQTISAATAPDTTLKSTKLLNKSTRDFMSLVEPSASSSALRSSAEFGALQKELEELRAKVRVLEKKRDDERSQIAELEKTREEAERSIAAVPKLTAKVQDLQAELKDQRKLEKDWSMQKDDFERQLARLNDELESLTLDREMAEEKAETAALEAQEHLLSLETANAKIAAMEKDLNPHLLRRRTESDEPGAEGAEDDAEEEAEYSAAAELVQRENDQLRRVLRDLRDRSNEIEGEQRRKIIELERENAELIELNSTNDSLLPELENAESMIEDLKLQLDDALGAQDLVEQLTERNLQLSDVVKKLRDEIVEHETIAEINNELEEQHTINEKELREEVDLCESRIRDLAARNEALENNAVDYQNTFGQFRELVSNLQAELEAAKAEQAEYGGAEGSGRKQMADQAMLNLNLKLQSSALKSQAKTIDLELGRLQAAQASSHLEMVRTYLPAAYFEADADAVNCLLFFRRMAVKSDLIKTIVETNHDIHESLSGIVPEAMVGVCQMRHSIAHFSALSQQIAAVLRLAPPEVFLRGGRMYRENMAIERKVDAFIGALRREELKEHECGLEFGRFVKQFEDFTMALGGDENDSDLAAKEVGSANLIDHDLDTLVAALGYAKQQLAQLYADDDDVEWELAGRNIEDDLFDPLQELITRIRNTKVLTRKVLRRLLSLADNDEAVRMEAIMHLPPLGRVTSQLVTFATLLCKTVAAYVGEVRTAKVAFDMTRVLDMVGAATEEGLGKRDVNLWSGPLESTSQLASTMQTVLGAIVEQENVMRISGPGPWLSRAEEIKTLAAQNPELERQVGKLGEDARDLLRQVKARDQALQEGAIKIERLQKQLERARAQVDEQSDVRTTLGEVQRQASAYQEANDALQTEIEALQKDHDALKLQVATATEAAGATAVEGERERGAGVPARVEGAEAAAYTSLETSYLVGQLEALKGALRHLRRENAVLKGHNLLQQMHALARLPKPVPKPAAAAVEVKVGEPVQRMPPRTVAPKASARAEASQVYSSALSALALSTVVDLTPLTRRVEGEEKRTRAWVPHDKQPRVQLEQHALTRARLVKQLAAASHRLSPHAVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTJ5</accession>
    <name>W3VTJ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00846</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTJ5"/>
    <dbReference type="HOGENOM" id="CLU_038700_1_0_1"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="203"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="388" mass="40531" checksum="1F626951BC3CE029" modified="2014-03-19" version="1">MASSQSCRTGVAGLLRNLSSAHASTSAHRGSASIRSRCLSTSASASNAQSSSTWSASSPSQPSSSPSPSSSSSSSSAPAPRASSAAPAKPSKAVKTIPASSPLLDKPMPIGFPSSTLRGFPSLLHFADPVLDAHPSNVMRNKPTTSMPYPSSVTFFNEPRMFEPTPPSADSLVLSSGSDADEVNSEQYLSTVTPLSVREVRDLHRHAIVLKRVVHMTTKGKDASMYALVIAGNGNGLVGYGEGKDTNASKAGRKAFHEAVKTLDSVAVHKGSDGSRTIETQLEAKWGASTVVLRPRPAGFGLRVPPVIHAICRSVGITDLSASIQGSTNPVNVVKATLQILWGGAAPLGMGDGIGGQMRRKDKGRGMRSRLDIERSRGRRIIEVNAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU37</accession>
    <name>W3VU37_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU37"/>
    <dbReference type="HOGENOM" id="CLU_425892_0_0_1"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="5">
        <location>
            <begin position="96"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="6">
        <location>
            <begin position="595"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="79623" checksum="DDC1D385046E6147" modified="2014-03-19" version="1">MLGQQSSSGYEVEHPPPPSKAQHPAELDSQAYIVVAHAEGRSNHFVFSSAGQRRAARRREKRLDARRWQRQLQGPVALHALLSIGTADAWLKHTLLVVGGAGFLGSAISKAALAKGWRVLSISPSGTPYHTPAGHRPAWSSSPNIEWHAADALDPSSYSHLADRATAAVHTVGILLESDYKSKASSASPVRNAIAGVVKGWGIRLPNLGADSNPLDDSGTRAGPSARQGRFSYEHMNRDSAIAVAHTFLSSLRSRAIAHKQVDAPSTPAPFVYISAEDLFRPVVDARYIRTKRQAEAAIARLASHLQAPQREHTRDQSEAILDADGAGLEQELRDDPVNDSASSSDGQARSDAGHGLVRPVFLRPGLLYHPHTRPGSTLPAAILEASAALHRKPPLPLPLPTPAQLLARLGGGGGASESVARLLTTPPLHIDTVAKAVCAAIEDPEAFGVVDVYGIRKLAGWRDEASLNASVYAQTVAGGSAQAPGAGMSRPWPSAGQHAPLQPASRPASPHTHHTPAVSSSGQQRSLWVPSRAYTPRSLSSGAIQQRRTFFGLPDLGKLASSAISSATGSNDGESRSYRDAHGRTVYETSKVLSHPADTLFSVVANVDAYKQFVPYCQDSRVLGPADPQQPTAPAVLADLTVGFGRFSETYTSKVTMTSGAKDKRSVVAEAVQPNPVFSFLETRWTFHPLPSAEGRAQTMVEFSLVYAFRNPVYGAVAGNVFEQMSAQMIDAFERRADQLHPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU64</accession>
    <name>W3VU64_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU64"/>
    <dbReference type="HOGENOM" id="CLU_502671_0_0_1"/>
    <dbReference type="OrthoDB" id="2555749at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="456" mass="49950" checksum="4FD29738663C167C" modified="2014-03-19" version="1">MSEWSHSLGYSAADIFPDTDSEGEGEGGSTTVADGPVSAKTVADDEEKVDFIETPFTIAARNALFRKARQGAFPARETATPKSTDDKGKSRALDAVGEYHSPASELTPLSEAQAPPHRFSCHQEPIEVIVVSSDSESEEELTSGSGARHAGANDAEPERSGAEHGSEVELGSESILDQLFEENHEFYDRLGREVIPRGRATSPGCSSAQMDTLMTDGSTTYDTSSWAPTEPAYYHTPSGYPACDPVPLHYPSPHTSEGNADQYAPVRWQQPHVQTTDHHNGYGCMEPQTIGCYYEPHVHNHRYDHPPMAGQTPWQPEIQEDTEKADSTDSNRASSSRHEEGEEWSTLRATRTRPDGTLSLTAAMRRPIPPTRLAPSSRGGSRLALPLYRTVGSSAEERRRAENLLDRPPSIVQTGRKREEPVVSPVAVAPRTKRLFQPAPLPPSTSSRTVTERDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUF4</accession>
    <name>W3VUF4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nad-dependent epimerase dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUF4"/>
    <dbReference type="HOGENOM" id="CLU_855629_0_0_1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="325" mass="34370" checksum="CC226530E13268E5" modified="2014-03-19" version="1">MSTLTQISVFPASSASASRLSQLLQDRHPDIRVRLAARSPAKLQASGSNVSIAQSSLNVSDLASIKDALDGSDAAYIMNPPFYGEEDPDTLSKTFIDNIVAAANASSTLKKIVFLSSIGAEKASGTGPINNVRIAETGLLADLRDGVEAIALRPPYFFSNFNSVLPLAINPPHILPSMLLPFDKPYALIDSTAIAEKALKYLIAPPSSAADAASKGHITAVQLVTAPKTVPEIAQIVAEITGTPVNAVPVPEDQWLPTFQNAGMSDKLAAAFYDLTKASNTGHVSYLDQPRIDAEAQRGVAVITEHTDVDTKAALQRLIEEVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUH9</accession>
    <name>W3VUH9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUH9"/>
    <dbReference type="HOGENOM" id="CLU_270026_0_0_1"/>
    <dbReference type="OrthoDB" id="10511495at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="875"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1208" mass="137053" checksum="F363A7BD9A9148B2" modified="2014-03-19" version="1">MEVFTDLLHVNPDHHREELALLGREGSGTAWRPAIPWPLPVSSSTEGDTLFFPDFRDQDCPEDRLDEQGYRDLALSYSFINYRGRHVLKVEPDTQKELFRTSFVWNLPFNEEIRQRILRGPPDVSSKMAWTIPTLRANASKDLAKRVFPDPAGPQAQEAAQDDSVSTSSSSLTPVSASPRPSSPRRQVTGLNEGRLIKNERERVRVGWKDDTGAHFWATLPLTLGSLHLAIFRSIGASTSFRVDFQDRRFNKSVGRRVGPILEARIRAFVEASPDYATLDGDAETFADFFISLTGEYRASFESPSAYEDLVFKLRAVHNRQSPKRKGDIIFVNDVRGRLSHKSVFVEDGQRKGSFISVRMDDRFRDMYLPRLADILFSLNVTLHISVEEQEGQSIEQQEDRMLHVLVSRALRCLLYYPVAHRLTTTTYEEALHIATEWMDILSMRSPQRPRLLQYVVRDTQPPIYAVQLPAPHDEARTTLSVHLVTRHPDQASAAATSDRIEDYLHDRRLGALDPHDCFGCWYLIDGPGELVSTYWGGGTIPGVTFNGLRLLDVVNARGLDLYRCALPGLAQDHKGCDSGGMHLCIRAGSGAQSRSRPFESDLRDLVPHEGRGPLKCHVLYTFSLCWYHQAVRSSLYAVATDRFFEVRWSSWSDVQTPVDGAQPPLSLDVLKSVVLPTHIKTAPVLTSHQDRASIVRFWLHGGDVLGQLKLESLLCEYRGVPGSVFDCRLLLNTNTRSLRDRRDLYRAALPSVDKEVHFLRDGSQHVKGNLKITDLQHNLAKGHAFLPFHADLLELSLVCHQLISPLFPAKAEAMRRFVEATLSDDWQVKCSQFFVSHAQRRTHSKGLRQRSDEAFFQMAGANLIRGPPRRLVTAALRSADIEEAEREFEELDDEMVSGEFEVVEPLNILDLKEERKEMEVDDADEGRWTTRAVNPAFLQRTTQEAALKVIKEMEAHFGETSGCRDMQGFARNRAGLPVLVGDESWNWQKLMRFYADRLERSFVCEQARPVAADQGDKGPIDDVTGTHAHLSGYEQRSPVTLLLTHYHQQLKYGTGRRCHLTGLALVAEVGHPLKISLGHRVHGWKMWHGWSAQVPQSFSQFCEEANNVVFESWWANSWRRGWRCLRASLPRRLLWALDWLEAASMCDVVKHFTHDELETIRLHYENGGTEAAPSFEWTVGTDPLVDINVLSPAEQSIVWQRVYGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUI6</accession>
    <name>W3VUI6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUI6"/>
    <dbReference type="HOGENOM" id="CLU_035750_3_0_1"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS65209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="294" mass="31363" checksum="673691EB16B33A01" modified="2014-03-19" version="1">MAAATAHTSAGIGSSSGFDFSNYSRNTFLSAQGLGGFTATSTGTTIVGCIFKDGVVLGADTRATEGPIVADKNCEKIHYISDNIRCCGAGTAADTEFVTQLISSNMQLHELNTGRQPRVVTAMTMLKQRLFQYQGHIGAALVLGGYDATGPHLFTVAPHGSTDKLPYVTMGSGSLAAMAVFESGWTKDMERADAVQLVAAAISSGIFNDLGSGSNVDVCIIEKNKTEYLRNYETPNERVQKEQKYKFPKGTSAWTKEQIYDMIRKQDVLEIGNHAPVPEVAPPAGAAEETMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUN3</accession>
    <name>W3VUN3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUN3"/>
    <dbReference type="HOGENOM" id="CLU_050272_0_0_1"/>
    <dbReference type="OrthoDB" id="3366475at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="344" mass="37533" checksum="7DB2E06663328967" modified="2014-03-19" version="1">MDAMRSRTSSGESSDSMHRARASDSDASFYRRSPDSTPTRRRSAQPRVADEPSILGSIGKLVRLALLALVLAMVVPYIKTRMFGSTSSTVGNATRALKNPYSHAESVVEAVQAAAKEPDVFNFKHQDYLRQAHTPHPSIALQPKPKPSTTSKAIKPQPTISQDSDGPGVFSQVLAVASSFASLLVTAVRFIVVPFRLAGRALGSGAVWIWSMFRVALSHVLRPLAYALAPLSYLVSGILYVFVHVPLRVITTVATELYPVYIFLGAASVVGITMGIVAAAVLYLTAFIFVDRIPSSKVEHPNQNNVESDDYFNTNTKQSYRRSRSAYPNYSQLSKQPSFQSSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUS9</accession>
    <name>W3VUS9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUS9"/>
    <dbReference type="HOGENOM" id="CLU_031403_1_0_1"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000006">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046825">
        <property type="entry name" value="PDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20463">
        <property type="entry name" value="PDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="467" mass="52271" checksum="F21620E40AE06144" modified="2014-03-19" version="1">MGSTSEMDTVEIGIIGMGDMGRLYATKMRGAGWTKVNVCDRPENYDKLRTELQGSGLNVLRDGHLVSRRSDYIIYSVEAAYIDAVVAQYGSSTKIGAIVAGQTSVKAPEKEAFEKHLPNDTYIISCHSMHGPKVDPTGQPLILIQHRAPDEKLRLVERIMACFKSNFVYLTYEEHDTVTANTQAVTHAAFLSMGTAWSCSNQYPWESERYPGGIETVKINICLRIYSAKWHVYAGLALLNPAAKTQVTQFAQSCTMLFKLMVAEREDELMERVFAARRKVFGWENEEESNSVISRTGAKEERKPILMSDKLLDRFHMAARKAVSSGASESAQATQEAVKAAAAATPPNSHLSLLAIVDCWSELGINPYDHLDLAATPIFRIWIGVCEYLFRSPERLRQACHAAARDHSFRADDTEFVIASRGWAQAVQFGNFDSYQRRFEETRRFFEHRFQEAGAVGAEMLKVVLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVM7</accession>
    <name>W3VVM7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004025_1_0_1"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="439"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="768"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1620" mass="174536" checksum="C04A873AEF6E6FF2" modified="2014-03-19" version="1">MSGRSNTIKDLRSKIKHENASLGSGTATASFNSARHQVAHVGDAFGHHPGSASLGGAPMSAFNTSSAPSNYTQPQSGAAGLGAGPSFVSLAPSDSISNFEGRQSHGYPSSHALHQDRHNNGTAFHHSNPTNPPYPRSASPTNQSTASFALASDHTPTPSTSATVSHQRIPSRVDAVDPNANSPLRPARSVRRPQQAPVPVSHRGLAAFSASSNLGERVRPAAQRPQLQIPPVGAAPRGAPSPTSPARNAPGRDLLAASRSQAATSHSRNPSALTTASSSTLSPHATPPSDRHTRSAQLMAQVARSGTPSSQPDSEDHEDLYSPIDPPSEGHAALYSNHRAADRLSVPGQRPQRDPRRQSGAPLGSLTESNQPAALDSVLSALTSAGRKRQAARIMRGTTAEEESRRRRNEKKISQHPQQARKPVSAYLDRADPRAFQSINAVLRKVEAEWPFVADDHFNSVALALSMLDDSSLGTSRAEFEQVKQLIETALQGTVDDHYESFATAITMHNSVLQSLTAAQSSVSGARRRLRDSREALGAKRADLVQMWQRSQSVKEALRLLDLVEHLKSVPDRLESLMAEKRFLESVNLLVRSLKTIDKPEVLEVGATTDLRAYLKGQEQAMLEILIEELHNHLYLKSYFCDARWKVYSAGQESLPVVRFGSDYTPSKHEARGSDADASAQSSDATLQLTRFLQSLRSRPSFDPNLASDIQEATLMTSTKSVSALTGELKSPGGALVGSSLDASDGAGSTELGAGRPAGRYGAEFDRNPEADSFVYIEMLLESLSRLGKLGAALEIVSQRLALEVHQLVDTTIDEVDARNEPLRRFSIALRPESVLLASSSALARSFTESMRSSRSSFSLRTSRRASSMLRISAGETSALQRDGETMRDLFWTLFSKLDAVLQGHRVVYEVAGMIASRAGFKDETASKKLSGVASLLDVWKPIQHEVRTLLHDYLMDDEGSTSARNAVISVNDVLVDQRFGRDRSKQLFKLADAGTQRAPVKRDAGPLAKHQLAVAQALKASVPGLVSTLDGAAGMGGARAGNQIIISSSAANAGASTARGVTTGAGTGSVSGRGRGVESYTGPGHRLLVKPDAFNVSVLFQPALAFVERVAAVMPSEAAGETSRGFSAFLDEFVQDIFLPQLEDKVQTLFTGATGHTDSFAEDPASRQLGRTAASRPVVKSASNVIVLIDSLYSMLRTTPFHRESYSRLIVTVVIQYYQKCGERFRDLLSHESASDGSESKPEEQGGYSLSANWAQRPEMVACLAELRDGATTAERRAQLLAQEVRLELAYARARAAVAIHELTTSRKRLMALGCLQHSIEWFASNVGRLKPVCEQHTARADKDALGSSRPKARLSVIDALTLTDTNLGHTSKPDGEDEELALPLTSELVSRFPALAGAYGQLASTVLYTLRLEVRLRVIAYLQHAVLESSYAVNQNAVEPAPHIVDLNAELASIDDILTETLPAESRAFVLEGVAALMDAHLVRLVHSIRAVNVQGVTKMLRNILALQQNLKNILPGKEVSFERARRFYELLYAKTPTQLLAGMRQFQTAQKTKVVGFAELQTVLHLALGIDASAKGEGAQDKAAGTINGADVSRPKLNEYLIELHELAGEHESDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX81</accession>
    <name>W3VX81_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00171</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX81"/>
    <dbReference type="HOGENOM" id="CLU_024775_1_0_1"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000036">
        <property type="entry name" value="Chromosome 15, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="10">
        <location>
            <begin position="52"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS65437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="533" mass="58245" checksum="6DD71F7316E89361" modified="2014-03-19" version="1">MNMLSTSRRMLSWQPACRGLATLSSSNSVRPLIASLPPRSKYPPKQPELAVDHLIVGGGVVGLSIAAALAARWPEKTTYLVERNKSFGEETSSRNSEVIHAGLYYPADSLKTRLCLRGRELMYERCTQHRIPHKQTQKLVVGGDHAKSYLEKLQQHCASLGPLAPPTRLISGSEARELEPHLSRNIGWALLSERTGIVSSHELMASLERELLDAENAEVVYDTKVVRVDPSEVRAVSASSKRGDDGSNDGWIVQTVTSETTGTTSEADALLAKVVINTSGLNAPMVLNSLLAELGSDEAPIPMWHSKGNYASYKGRGADGIRHLIYPVPDTRNKGAHAHTSLGTHLTLDLDGNVRFGPDTEWISPPETTADTQQAVDFWKHALTVDEARIESMYASITEYLPNIDKAGLAPDYAGIRPKLIGPEHKAFMDFQLLWHNSSDLRAQRLWQRAPGLPSPSASCVSPARQSVDRIQGGAMLSLLGIESPGLTSSLAIGEMVRDIVAQSFYNEKATRQPSPNKGARNEEHAHRLDAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VCS3</accession>
    <name>W3VCS3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VCS3"/>
    <dbReference type="HOGENOM" id="CLU_010508_2_0_1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14655">
        <property type="entry name" value="ZIP_Hap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="780" mass="85773" checksum="B16C9A65CA61B462" modified="2014-03-19" version="1">MNDPNDASTGRAGGERAPKRKRLSHACKACRARKVRCDERLPACTNCAKLRIQCITDDPRRPHIRSVTRSRASGSRTSSTLHADHQPQAHQPDSTAVTQSKQNDAPAAVPHEDEQHGSRASSPWADPTWMRNALGSTSASIISDSHAQDRFKYVGSSNLQVFSNWIDLLLARQRNTTSTHARKPLPSASISDHFDHGRIHSEEFHFALRPALPGLTPLRHIDAILEAFFDNANSVFPIFDEALLRHQLARLIQHLRLDDPSAMQLDSLSPYEVPMLATLYVVTAFGLLDVVPRQQPEVKKYLDAAYSLYGHMIGVPYLASVQALLVLHLALRAMSKDGAAWQTLGSAIRVAYSIGLHRGPVSPPLHSPALESTKARVWWCCYVLDRVATLDSGRPTMINDLDVQLSALRIPRQPASDLVAASSADDPASMTSLPDDLFNERYLASLVALCRLKADIHSKLYTSRNHSLAEADLFATIAKMDAKLMDWSSSCLVHLRLPTMASEEALRAVSKSRDLRVLHLLCTYHFTLINVHRASVMLDTRLYQHHVAQTLTKRSDRLLSAETICRGSARTIIRCINQFRLLHHSTARMIAGTIPLSAVYVLAICIFKHPKQWSVASDLALIESIAKTVAQDFENDGMPAGFTSIFATLQQLATQCVRHVSSRPSSPPLADLDTLQAQVSLEPFWKSLGFGQVVSSVGDETQSSQPAATNFVSPADSTANAARPAYATEDSDEVPSFQSLLELDHPDQLLYSLLGLPEIFTPGAEASVETGLLGLDEPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDE6</accession>
    <name>W3VDE6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDE6"/>
    <dbReference type="HOGENOM" id="CLU_886227_0_0_1"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="33890" checksum="C8DDF34193597AC1" modified="2014-03-19" version="1">MVSYKELARKNDSIDATGQRALVAGGTQGIGAGIALRFALAGASVWLIGRNEAKASEVLEQLRLASAEAARRANTATAHTDHHFFQADLSSTAGVNKVAQAVTAKAGSRGIDYLIETQGGPPHGGIETTPEGVETQFAVQVLSRVGLAKHLLEANTIKRGVFMVAAPGQGSKSPMDLDDLDFVKAKAAGKWWGGPFGLLKKGTQASSLLDAACARLAEQHPNLTITHAFPGFVNTQALANQGHNSLLVLAARVFGPIVGAKPGPGGYAELPFYLLANPEGQRYLETGKPNLVNDSLNKLNMSNNVADKPTRDAVWSKLAAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDH0</accession>
    <name>W3VDH0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_06497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDH0"/>
    <dbReference type="HOGENOM" id="CLU_021377_1_0_1"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="136"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="11">
        <location>
            <begin position="520"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="589" mass="65084" checksum="DC66D614998709A4" modified="2014-03-19" version="1">MMMSPAIRAGSLRAVASPSMALRASRLGMPSTSAAPAASVAPVSRMLRDQQQIRGIFRSRSWRNDKTAAVAQAAQAEVQAQLPPPNNGGKKRGGFFRGLKRTFYVLAIGSLGTYAYFVYQGRHPPDQLPQDPTKKTIVVLGSGWGATSLLKNIDTEEYNVVVISPHNYFLFTPLLPSVTVGTLDGRSIVQPTRHTTRFKTREVKVYEADCEYVDPINKTVTFEDRSEVKGSVSKVTIPYDYLVYSVGTENQTFGIEGVKKHACFLKELSDAEKIRARLIDCVESAAIKGQSEEEIDRLLHMVVVGGGPTGIEYAAELRDFVESDLIRWYPEVANKLRVTLVEALPNILPMFSQTLIKYTESTFKENSIDILTKHMVKDVDERDVLVKTPSGEEKKIPYGLLVWAAGNTARPLTRQLMAALPEHQKNRRGLEVDDHMRLKGAEDSVFALGDATATHFAPTAQAASQQGAYLARVFNQLARLQVLEDKLAASKKAGADASELSGIERQIEKAAKIRPFKYSHQGSLAYIGSEKAIADIPLLGNNQIASGGVVTFMFWRSAYVSMLFSLRNRSLVAADWFKVFLFGRDVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDQ1</accession>
    <name>W3VDQ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_06255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDQ1"/>
    <dbReference type="HOGENOM" id="CLU_014210_0_0_1"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="620"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="682" mass="76230" checksum="5A5C4140D91F1D6B" modified="2014-03-19" version="1">MAEYKYDEEGGQFLTFVLTFLLLVLVPLTYSLLAPSRSHRSAKGSWDARGQKIDLIRSSKKRSLLNPQISPRAVFVFAGWGVVAYLFQTILNTATNSSHAVYDPFNILGIAASATEKEIKKHYKRLSVKFHPDKLVLADNQTKEEAESHYIELTKAYKALTDETIRKNFELYGHPDGKQEMSMGIALPRWVIESQNNVYVLGIYAILFGIGLPFLVARWWYGSRSKTKDGIVNSTAQTYFQHLRDDTDASRVFALLAISDEFSDAKLDKLGASHRDEATLAKLEAEARKRLDAYGPQWHLIDSFKNASIRKALVLLYAHTLRIDSGDKRIEQEKLRYAAKAVQLLNGLMAISLAHNWLETTLLLMQITQCMVQAVPLQDLSAAELLQLPHMTPELVAKLHQSNSLAKLGVQGFWKIPDAERKAVLTGAGVSAQQYDQMVAVTSAWPRIELVDAFFKVSGERLVTTGAIVQFVVKLRLLPPKKDGSLLRDGRRLDAKRMDDDSSVRPDDEEASDKKTATGGEDDGKQPIGFARAPYFWDERKPSWWVMIGDQKLDRVIVQPTKVSDVGADQVRTYSVQFQAPPQAGLYTFQAILKSDSFLGSDASRMVKLRVEDASVLEADDHEDDISEPEEDSLAGQMALMKGQKVKPSSRVDEESDDESATDDDVQDDDDDDDSDSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDZ0</accession>
    <name>W3VDZ0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_06272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDZ0"/>
    <dbReference type="HOGENOM" id="CLU_1696273_0_0_1"/>
    <dbReference type="OrthoDB" id="16434at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032053">
        <property type="entry name" value="Ribosomal_mS34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS59749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="155" mass="17252" checksum="030D19C5F24BE704" modified="2014-03-19" version="1">MLRRTLALFAEATRSSSKASSSSDVLTSHFAKSSLPPTLARSAQPHKNLYQLLSTLPQDGVGARVRQRRWAAKGLDVPRDVDLKKHLAQMHAKGDKPLKDDAHLCYWEITKVRLKDGGNHGKAWGKLVWRGKTITKAETGERIPGALKYFWAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE30</accession>
    <name>W3VE30_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE30"/>
    <dbReference type="HOGENOM" id="CLU_004991_0_0_1"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="3">
        <location>
            <begin position="423"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="4">
        <location>
            <begin position="634"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="840"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="809"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="106836" checksum="240F0DB6B0A4125C" modified="2014-03-19" version="1">MDGWDTPADYSQPPPPPQTNAAAGWANSPRRGGGRGGGHRGGGGGGYYHNNNNNNHHNNQQQYQQQSDEQRNENRIRYIRSHLFKLGEDKDFHPPSDLLKMARWIHDKAHDGLDPITAAFRVMVTEQPHKIPLIAALIGFLCLQPNADPARIRQHPAQQAQHGDEHLDDHNAAADEPAPSIGLLIVNDLIKAFRSYLDARLWRNTRLSLHLFAALVPLHIVPAHSLRALLSAFAAVLDEPAVAAPRADRAAMCIIQTLCRAGQDLLTDGDHARAELDQLVQRVVAYDAARKVEVQLTQPVHDVETIWLDGFPHAVQALEELRTRDYARPAFLPVPADLLPAAISPSATAVPEAHRSVLLPDVLVPPEEDAEEHNLDVAYAQLGEQQVKRRKVDTGKGELEEKKAAVGPERISLEPRWFAATVPALASPAAVVLRAIVADMMDLYEVNRKEAARLLLDLPNWLRRGTFTGKVSPEAGLFGELDDKPQESGWSLDDLLVESILSTALVLPSPPRNPLYYTALLREIVALTPGSVAPSLGRTIRTFYNALAEPKMDLEAVQRFADWFAIHLSNFNFGWAWKEWIADTALESNSAKVVFIRRIVELEVRLAYYDRIKQTLPAEIAQLAMADEEPGAVFTYAGPEHPYHAAATALLSSIRAKASADVILADFESFKASIISQLPQDGMVGSMDEAEVVVRDLVVQCVLQVGSRSFSHLLNIVERYHGLLRTLSRSARMRAAMLAAAVRFWIRSPQWLHIVVDKLLQYRIVEPADVVEFIFNPPRDEPASILTAGVSEVGSWAGFNTWGLLKLTLDKVNGRVDQLRRRLEQSQRLEAEELERQEAAAAAGFEQEESKAEPGMPLFPTTATLPVRPEEKAPSADDARASLDAIRTEQRKVLLTVVQGFLALKAEGWNKWWVDGWYTAFVRTFNRQLLDNKQTVLAICFQDGHDEKKDILLRAIDMLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE79</accession>
    <name>W3VE79_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE79"/>
    <dbReference type="HOGENOM" id="CLU_084051_0_0_1"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="220" mass="25405" checksum="4BA845201D14012D" modified="2014-03-19" version="1">MGRRPARCYRYCKNKPFPKSRYNRGVPDPKIRIYDLGRKKASVDDFPFCAHLVCDEHQQITSEALEAARICANKYITKTSGKDSFHLRVRVHPFHVIRINKMLSCAGADRLQTGMRGAYGKPYDTVARVNIGQILLSVRTRDSNKAVVLEALRRSRYKFAGRQKIIISKKWGFTNMNREQYAEAKQSNRILKDGCYLQYINNHGPLEKNLRLQARIASQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE85</accession>
    <name>W3VE85_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_06174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE85"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_6_1"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="133"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="352"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="707"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="791"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="872" mass="92253" checksum="AFA219AAED975658" modified="2014-03-19" version="1">MDSNSLANRLGPQAGGQGAPGRGGARGGRGGRGRGGARGRGGRGRGRGGSAATQQNVDQANAASTSTVATPDDTPLPSGAATPTWTPKSIAPGTDAAVYLTDNKFADLKGQIDNRLLSAIPFPTMSAVQAATLSTALSGRDVLAQAKTGTGKTLAFLIPSIHKLCALPTPPPQSSISVLVLSPTRELALQIEKEAHMLLANLQGTFGVQHVVGGTNIGAERKRLQRDRKDLLIATPGRLLDHLSSDAPGLDLRKACQNLKACQNLKVLVLDEADRMLDMGFRNELEKILKMLPDPVASQRQSLFFSATIPSFVHDVAKLRPDHAFISTLTEQDTNTHEHVPQESYVCSLRECLPRALQVVLAEAVRYPANHKILVFLPTARSTSLAAAVFSQLRGLAGSPYAKLGQVFEIHSRKSQAVRTKTMETFQSSASGILFSSDVTARGIDIPGISLVLQLGLPSNLEQYIHRLGRTARAGKEGRGVLILADFERFFLGQNDVKRLPITQLNVRAVEAESGVALGEVAQHVDRVMQGIDATTRSQAYQAHLGFYKGYLKQLRWKPEELIDATNDYAKDILQWPAQQDGSWVGPPLLQKTVSLMGLKGKRGLHIVKELPGKPNGAGQKRQGNGNHVAAQSNRSDAEHKLIKRSPKTVVHHHYHHSPAPAPAPAPASGGGGMFGGGAVKNIAAGTVLAGTGAFAGTIGATEAKRLLGSDDHDRDNNDGNKHQAREKDDQQNTQPQPQPQPQGQPQGQQVQPQAQTQQVPANVAAGQTNRHAYPVAILMSDGSYEPLPSQLAAQSANTADARATAGQQDRSPLYDVDTSPPQPRYQAADAQPQYPNYAAPGAGAGAGWGAGAGAGAAPSADTGGFVFPPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEA3</accession>
    <name>W3VEA3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEA3"/>
    <dbReference type="HOGENOM" id="CLU_007286_0_0_1"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="133"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="4">
        <location>
            <begin position="803"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1072" mass="121452" checksum="C313CC4B5A1D9A2D" modified="2014-03-19" version="1">MSSPVRPHERRTSGNSSDRPHSSSSEPDDQIHPAGPLPYHNHGGYESRSSTLNQSSLSPHDRASLVSTPGNETPIAWDRTATNTPTGDEKSASLSEFKAAKDSAGAVGSGLIKEEKKPRADQPAKTPANGYLDYADGLRGIAMILVFNGHFIDNTFIATHPGTIQNGTPVGILRSPMGLVLFYMLSGRLNATSYFRNKSLGRPIRWSVLPEAMVRRAIRLLIVGAVWLIIQKVECGTHAFDQTVIAEGWLQSGNLGYPQWCNVDFNNPSPYASDWNISTSVGDIVVGLLRLATNRDYLQQLLNTSMLWSIVPQLWGMLSVLMLLPIVMFLRPSRRFVLYALLLIFQGYTYNQNITFTVGAVAADLKASGYIKKFNQKSRLAFLATEVAMAAFFIGTFCYNPIAVGIDRGLSKVTNRDGTLGYDITSFTAGRMPSYVILAGILYFWLEMSVVLQWLIGNWAFKALGRVALGFYVCQMSIIYGVMPHLVIIFRDKGYSFWSNMWSTWAITFFTAYVIAWIITHTLDKWAMQFSDWFASTIVRNDTATTLRMSAVNTARAVVFGPPAIARATPGWCRDKWAQTKHFFWVLFHWRTMVEAPAPPSHPMEVGLQMNQLHSTLFDADISDDEQAVRTRWMLRALSFLAPVQVLIILGLGFIWMWFNPWADYILDGFADFSTVWRLLWALALPYCIITTLGFATPDITRTTEQLKKKPVIREHIHRLFIVSVTRGSNPETTRRAHLHLKKLEKYHPAVRAIVLTDEPYYYPDLDNVMTPKSYKSPLGKAKHKAKALDYFRSSMGLTPYDWVLHMDEESTMDAESLRGCFDFIRYNTAHIGQGIIIYNGKRETYWGNWFFAVADCIRIGDELARFSLQGNIIKRPVFGVHGSFLMINGDVENRVTWDFGSLAEDFEFSQAAWSKGFTLGRIHGVVREQSPEGWMDFIKQRRRWYMGIRGINGLFFLPQIAIKLWTAGIFCLVATLINIPFSLLLEWSGPTPRWLYVISCFCFGNFYWLYYSGLFFSEIDYGYKWHQMWQIPVHAVALLILQPIMAFVEGMAVVYAMSTEDGEVGFQVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF13</accession>
    <name>W3VF13_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF13"/>
    <dbReference type="HOGENOM" id="CLU_295969_0_0_1"/>
    <dbReference type="OrthoDB" id="3366950at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="871"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="927"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1109" mass="119721" checksum="283B2AC415D1A8E9" modified="2014-03-19" version="1">MLSSRAAAGGDPTEVSETAQALLKAHYGRLRTATHSSDRTVLARLESAAANLERICLQLDNIQVAHELRSGQSSAQHASRILQPLGALAFWPAQLHLKDAGVFVRQDVAGLSITDQLALEDAALATLTRPAGKERITSSVRLSEPSRTIEVAYVKTSIKDAQSHLQTRRSRFLKHAAQLRDRIAPDSGRKQDEVQPKDMHMVNDQNQALNEEGLPFFEPIEKVSDEEAAQKKEAYMQPFVRDNDERAADKDKRRLWLEQTLSKLEQEEEQEEEEEEHDDADAAAQPSTSAADSSAPATRKDEAIDAAEETRVVLRTRTPSPPPSPEDQAHAKSLPEIVSAARPPPAKSALKMGLARPPINQRPSFGASGIRHGFLNLNPSSPGAIKSSYSWEDLEKEDGQERPSRSHTPTPLSRTSSTAETSLLGRVTDAASSPLTSGTSTPTKKSVRIKSPERAHPEASARSGLTPLQRALRSSIRVKENYADATPEPSTAADAASARVDSGSGTAEKRHRDDVGVEEEAERIVALLGPDVVEGHPSAPPTDVLRQMQQAHEEDKRLSTPEAVAARQKHEEEQREKERMQRLAEKPALGHAVMERPKATGGAAEVKSAANGATKFSAFKKGFLSQKPKFVPNAPGPRVPTAPTESLGMSALDRASMGDDELSARRQAMGLPAAVPHARPSKAYAEKMRQRQEGRVEQEASSPGEGGGKVALARPVDGDDVPRPGRVRFGPPASQQDHDEQDADDGVVEINPAAQLDNHLPAEVDDGRELDEEQEDPKIEGEGADADSEDEYFDSYLSQRSRSAAAADKDWDMDDDFDDDEDEYDYDADDLMALAPSMGGDADGLASHPDLMKEYEQARAKLAAMGLAMPGSSGAGNSSAAVLPADESDDDYEDDVVPLDAAMEDPEYQGNTVSDASGRSRISRFKASLQQRSASAAGASQKLEDLLSSAQNLGDGRAADGAASASAAFGMDGFAGPADKGPVMLIPQLAPVRFPKDGDLVEGGVTGPVALGGADSDDDDEKAEMVMRSRLERREWKQNNPDQARREKENRHNREMVEQGLAPPSVAPRRQAEKTYEPAGAEDGGSQTEEQQHPKPKKVSRFKAARQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF49</accession>
    <name>W3VF49_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF49"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_4_1"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="80"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="562" mass="61016" checksum="91CC98B98F8E35D4" modified="2014-03-19" version="1">MTAIQACARDAEQSSMEDKKSDGMHTSTDAYDVAPRLASSSSVEIVATDVRVVDSHGKMQRWPMPSSSARDPLNFSTWRKLGIVVSCCWFSIFSLALIGGLGPIMSTFYGLYHEQGPEKVTWLSTLPSVMVGLGNLIVLPASMVFGRRPIALGASMVLVAGCIGSACAQTFEQHLATRIVQGLAAGISESLLPLMITEITFVHQRSMIFGIYWASQNVFSSALNLAGSYQVASMGWRWFYWIYVIAAAVGVVIAFFFLTETAYDRPAQYKDGVYYVVDRFGVHHAMTQDQLRVAQAQGRFANAETQDAESGELGWMDTLKPWSGVQQPALRIAARTLWDVVLAMLCPSIMYMALLLSVILGTSIALSLTYSEVLIAVYHWAPKNAGLIAIGGMVGAFLGMLYSGPIGSRIVMAMAKRNAGVLRPGHYLVVAIVPGVFSFASLMLYAFTASGEATWAGPVMAWFLNQFAFTSMLIVGSAFASIAYPKNPGAALLLVVGAKNIISYGITQGTLPMVTQHNAKWAYGVLAAVTAAAYLVGIPFYFWGDRLDKWAMRQQQRFSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF71</accession>
    <name>W3VF71_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF71"/>
    <dbReference type="HOGENOM" id="CLU_071116_1_1_1"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="217" mass="23778" checksum="DC09E8E2D7D5DC48" modified="2014-03-19" version="1">MAAFKSRSSGAAGSAAASTSATPAPASLAETLSFHNAPRTFKSAEFSARMAKMSSNLARRNKSLKQMLQSEREAAMRAAGAKFKQRKKKDVQNKRLVGAALQAVARREERERAAKTEPEKEPTPTPEEDTPKEDALKEEEEDEEGKREVPTYSSVEAPPSLRPAKKYCDVTGLVAPYTDPKSTLRYHSVEVYEIIKQFGPGVDNAYLSLRGDASQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFZ6</accession>
    <name>W3VFZ6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFZ6"/>
    <dbReference type="HOGENOM" id="CLU_156745_1_1_1"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833019" evidence="10">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="114" mass="13424" checksum="999C3BD65248A3B9" modified="2014-03-19" version="1">MAGPNLELFKFGMYLFFPLAVMVHYGDPEWYHRNVLPIRDQFWPKEESLYRPPRTSDDVRTALDEMKQKRLARRQERLQLDQAQAQSANTNTEATEPKVISMLEDAARTNQRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG30</accession>
    <name>W3VG30_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG30"/>
    <dbReference type="HOGENOM" id="CLU_356464_0_0_1"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="710"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="81086" checksum="A33B36604EB03D64" modified="2014-03-19" version="1">MSFAIPQPPSASSDSGSSASLTPTANGHSLGASSSSGAPPASSSLFSSEESKFITDSLSSAESFDPFTIGAPGFKVPSLLPPNIAATHDHLASQSSSSANMLAHNALAEPGAALDMRTRSLSGQNPHAMAFTSSAPGHHDPSSSAQRLNSFNLYGHRPGGATPPGNSPFPGAHIHESYAQAHPAGRHASFSAATGPLSPAAAAAGYGKNKAWQMEQLSFLEAQASRGQQHSAAHPLHAALNEHQRRASASAIFTGPYDNLFFQTPAHLQAQQQHLLQQQQQQQQQQSAQQHNRAPFYPGADDGHAGLAMLGAQFPSSHNFGSLQQGAQAARQHDMRNAAVGGMPNGFSAQALAMFNRDAGLGAASLLGGAEPDEQDAGEGSSTPKGRASRASGPETGSSKPSQRGASAGWAAPAASSASPSGSTGALGLKRTSSGAPKTAPTQGLSLNAGPSGAVIRALADLANLDLDLEGALRMLPSNLHAHFTPPRLEKRTQPHLDMLRQQHIENGLIDASTGLEIKPEPTAEDLEREAEEAEKEKKQHTLLTTEEKKANHIASEQKRRANIRKGYELLCDIVPSLREALEREASTKTKCDDDSSDGSDDEDDKKGKGAGKKKKAAGAGKKGEAEGGIEIDGEKIDGRAGPRSEAVVLMKSLDHMGALVEQYRGLMGRRNRARLAVAKKFGWNALANQPVPDIDRLLAIKVQDWYAAHGDEDPNDDMLDDHLDGDDEEPEVEEEADAARKKSPSKTPKKSQQPRSSKKKTKEDVGMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG60</accession>
    <name>W3VG60_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG60"/>
    <dbReference type="HOGENOM" id="CLU_1046327_0_0_1"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="181"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="266" mass="29082" checksum="B2E9C77D7282A566" modified="2014-03-19" version="1">MDYIRQLTGGAKLKPDSSRGESPISDIVETAEEAQFNIDSAIQAVLHAAEVARHEIGDDTDVDAMETKDTTPSLVGDAIQVDAQQVRIEQDQTQACDAVQRSMTEEQAAQALHALYDATQHDAQVETQPSPAGQIHFADQAIPTGNVRTAEAMDESMPLFNPPEPVDVKPAQLHSSDEPSIALNIRDANGYSTIFRCKPSTKLSKVFKVFAKRYQTDLSKIRFISSDGRLLPKCNPNLTVQSEGFEDGDEIDVMLEQIGGYHVEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG63</accession>
    <name>W3VG63_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG63"/>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_1"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="168"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="327" mass="35088" checksum="822606BAA2017803" modified="2014-03-19" version="1">MGRVIRAQRKSGGIFTAHTKHNKAPAKLRVYDYAERNGYIRGVVKEIIHDAGRFSGGDGISDRSRRTEHRSTQALAEHSLEFIGTGRHLGRHGSIQASDCRQQMNANIAAARSASNVTCASIVHATGAPLAKVAFRDPYKYRTRVETFVATEGLSTGQFVYCGKKAALNVANVLPLSSLPEGTIVCNVEEKSGDRGSLARTSGNYATIIGHDSNGKTSRIRLPSGAKKTVPSTSRATIGIVAGGGRIDKPLLKAGRAHHKFKVKRNSWPRTRGVAMNPVDHPHGGGNHQHIGKPSTRSRFAPAGQKVGLIAARRTGLIRGTIKTKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGB7</accession>
    <name>W3VGB7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGB7"/>
    <dbReference type="HOGENOM" id="CLU_079108_0_0_1"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="253" mass="28819" checksum="6A0ADDD87429E248" modified="2014-03-19" version="1">MTDAYRQPEPKTFPDALQQKVDTLVEDFRKADAELIKHELKLQAPLYKKRAEIVSSVKDFWFQALINCMATNVYIDDADHEALSYLSNVDVERDLNDPRAATITFSFRENPFFSNDKLVKKFSLVDGADSLEDEFNFLEQTTPEKTQIDWKSDDKNLCKLKPTVGGPDSDDFEPGSFFSTFFENTDQEIAGGIGHAIIMDFWPGAIDFYTGADDLDFDEDDFDSEDDEEDEDDAEIDLEDDDQPPKKKSKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGC6</accession>
    <name>W3VGC6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGC6"/>
    <dbReference type="HOGENOM" id="CLU_006786_4_0_1"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="784"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1052" mass="115455" checksum="B60B31FBF79F3A8E" modified="2014-03-19" version="1">MPFDPRTKSRHTTALPAALRDELGLPPPSKRSFRPHHRGGPSNASSAHSRGKPQLKAIGRPQSALNGAAKGTPRGPIKSLRNQEKEAQEQQQHHRHGKQPAPQNALKNRANEASSSSTPAPKRKPEKQPEQPLKVIKKHKSENPSQPSGSESSTAHKTRLNPFTGEMERVQPAKTKASASKQTALEKMLARAEAGPSSSKAKPKASDDAGARKKSRRSMNQQEKEEEDEIRWLEYQLGKSRQGDDVVRDDLDDFLDDLDRFQVGMYDHSDSDSQDDDEEQDESDDSGLETASEQESDSREEDEQDTDETDESEDDKEDLDDEAVYDFDSNDEDDFSNWDAAMATTDEEDADQDDEPSSDEADDDSEAEEARALISGASATADSSASPSASAPAAPSATSASSTRYIPPALRAKLAAEEAASSASSTKASQGADAEMDPVAAQKLRRQAQGLLNRLGDGNIDTIVSEYEALYRTHARAHVTATVTQLILDTITSRSNLIDTFVILHAALVAALHKVVGVEFAAYFIQRLVEDLTRHYDELKRSSDQPQAAGGEEDVQGKECLNLSVLACELYNLHVVACPLVYDLIRMFLGERPEGSPATAEGGVGEVDIELLLRTMRSCGHQLRHDDSTSLKAIIALTQARVAASPAALSTRTKFMLERMVELQKSKAKGSSAEAANPNSAAGQLLTRMKKYLGGMAKKRSVRSHEPLRISLKDLRDADKKGKWWLVGAAWTGQTDQTDAQGLTKLLPMSARSDFIQSSSTQATIDSEQSELLDLARVQGMNTDARRTVFVTLLTADDYKNAAEQVLMLKLNEVQRREIVRVLVHCVGSEGVYNPYYTLVAQEVCRNDHGMRITLQYCLWDFLRDIGQSEVGGEKFAAAGFANEDKEVDPRRIANLARAYAWWITHDCLSLQALKTVDFTQVQPRPAQFLGNLVIHMVLSIQSKSPAKTLHLPTVTRPVQQERLVKLLQANLLGGSADLARGLLLFLSTNLDARKQRHLILGHDKAAKTQLKPLLDTVNHAVRLITQTVQAIVQQQDTAGVDDSDIASDDHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGF1</accession>
    <name>W3VGF1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGF1"/>
    <dbReference type="HOGENOM" id="CLU_267072_0_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="926"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1173"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1214"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1264" mass="135019" checksum="43728B1B93989CE9" modified="2014-03-19" version="1">MVRKDSSSSEMRYTCDQPGCTKSYSRPDHLLRHKLNHDQARVLCCNQCDRTFVRQDLLVRHLERHALRGKTLGRWSNRHKDGNDDDAENASGSSLSPSKSGPSSHKRRKSTSASDRPHDMDSDDDDDDDEDEDEQDRFRHGGTDPSASHPGSRPSIQSRYRDDPSQSLAPPPSNLADPASSSAWPSFASGPLASPPALPPAHASAQNAPTASWSSNPPMSPPAQRPSAAYSTSATGYRPLSLPTSDLARQSASEYAAAASSLAQPTPYASSTYRDDALWTAEHGHQNLRADPIVGADPVAPTQPNAAFRWMPTSADALSSDPTAGSYAPPPSASYLTAWTDAAPDAARDLPMPLADLDTSSAVPASARPPSSLPLPNQDIFPFAPPNVDHTADYGWLFDGVDPFGGSNWGGSIGRPATSGSNARGPHSQASAFSPSSSDGLGGFLGNMHGSQNGAASAAGAGDASSFGRGMSSDGVLMSGSEAETPNALEDLAYFASLQADIPSRITFHLDPVAHHRLLIFLQSVSELPNSPLFTPSALRCYIYLFFVKFNRLYPLIHEPTFAASTTDPMLLSAIVVIGAHFAGLPAHELAVRIAQKIWGAVVSLEDFRPARATLPMLQALVLTESFGKVMSTRPQHEMAHLFHNFIITLARRNAVFNASTQGHTHFDDSEESWRSWAREEEKKRIALFEFMLDAQHATIFRHIPSLSAFQIQLQLPCSDEEWSKTTPDAWHRHRKRTGYKPPGLFIPALKACLSPAKTPQELDAFPRFVLLHGLMSIAYDLQWKQNVLLGAETSPGGSRTNEAGIGNWKDRLSAAYSSLQARMDIAYIKADEESSARLIHRATPSLVTAAQIALFADIIDIQIYAGLPSVLGRFIDRATFNASRRSVKEWARTSDGRTAVWYAVNFLRTSLLGTGTESYGTIQTRGVGAAPSTEESRDAAAPPPGLRDRESNANPIGGAAGRKALDHESGLDEVLHHRWCQYLCALVVWAYGHALTIPRNGTTAADAAAGLGRAGASSTAPSTRPGSAHRNGNSTFGASVAHSPGAFHGQVSAERTPMAGDSANGEASVGQAGGAAQKPEGVDFLERMSTKTADDIAFVDCKCYTRAVLEMVEREVRASRWELGREASGVLRKLISNHSLPVWDRSKNADATAATGQLDPHRNDFSSLTIQQHAKPHQVKDDPDGRAGATQRSTSTATPHVRALASNGSSFGPANSTSASPAAKTTALPARGLMPSPSAAASRAPHTAPSGAKATSGPSPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGF8</accession>
    <name>W3VGF8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGF8"/>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_1"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04701">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="300"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="357"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48716" checksum="669A27A3F5A78C8C" modified="2014-03-19" version="1">MKRWRQLRRHVLRTRRSSQGLARPSVQVSNLPRDDHLATALGMPAAKDMEKAQRAHIVALVIHGGAGGTTTPDMPADLLEAYRNRLRSVLTTTYAAEHASSLDAVCHAVEQLEDSPLFNAGKGAVFDLAGNTVCECSLMTTQPHLNSNTVAVTGVERTKNPIALARVLMEKNKELGGHAFYSGQAAEQAGWKYGTKQVGKRYYWTKRRWNEHKRGLDKIQQGGSKHECFFDGDEDEDLPAYGEDAADKMEEHEDQAVFDRYANISDFLPQGTVGAVALDSNGHLSVATSTGGKTNKFPGRIGDTPSVGSGFLADSWTSTALHRHQRSWLVRVVQRVLLRAPPAGKAGKEQGVAISGTGDGDFFLRTCFASSIADRIRFANVPVEQAIKAAMAEIVGLYGKPKGVGGAIVLDGDGNAYFPVAAATMNRGLISKHTGFRPRIAIFDHEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGG2</accession>
    <name>W3VGG2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGG2"/>
    <dbReference type="HOGENOM" id="CLU_000288_72_2_1"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="509" mass="53271" checksum="26F9C6DA5CBB9121" modified="2014-03-19" version="1">MSVASSSASHAGPSGSSAALEQPALPPLGDLFARSSKRARVLFRIEDDYDFDNFGDASAFEPAKAHLSSKISSEYVDAKVLPPAILAQQQAAAGPARPGAPSATGAARPTKRRGDETHLSQLIDQIDTGGSASAPGVVGPVGPSTSQALTIRSNGAAGASNGHSAASAAGSNALALASHRGGTSGLLSQALIQKKEMASRKAKPAFHPNWKLARVISGHLGWVRCVAVEPGNKWFATGAGDRMIKIWDLASGELKLSLTGHISPVRGIAISDRHPYLFSAGEDRVVKCWDLETNRVIRQYGGHLSGIYSLALHPTLDLIVTGGRDATARVWDMRTRQAVHVLTGHRGTVASVACQASEPQVISGSMDATVKLWDLAAGKSITTLTHHKKSVRALAIHPTQYTFASGSAGGNNIKTWRCPEGTLVNNMAHDTLVNTLSVNADGVLFSGGDDGSLKFFDYATGVPFQVAEDVPQPGSLDAEAGVFCSTFDQTGTRLLTGGADKTIKIYKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGN6</accession>
    <name>W3VGN6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_228058_0_0_1"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="6">
        <location>
            <begin position="1350"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="1822"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="772"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1157"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1431"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1568"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1699"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1875"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2046"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2259"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2328"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2408"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2443"/>
            <end position="2568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1468"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1581"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1893"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1911"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1947"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2071"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2347"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2443"/>
            <end position="2460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="2461"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2471"/>
            <end position="2484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2502"/>
            <end position="2520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2568" mass="275317" checksum="9474E26683AC0AC2" modified="2014-03-19" version="1">MGSQQVATFHGYVHSTRDALLIFEAVRRGLMPKITRRLRDDERKMITSGTIFVFDEVESSIKRWTDGMIWSPSRILNNFLVYREVEKKDPKPAPDQPAFSTSNAAMMHGSSFAGSTGLDPSHSSVRSVPLTLMPNAIESDAPAMQYKQEGGNYASLHSGGSSSNAVYAGHDGFFANHGQQHPSAYARGHAQAAGMVGLMDDAAAASSSNAKREAELDRTIVGSLTSSYPFVRDGLCKKTISIQVEGSTQHLISYYRVDDVHNQRLTIPSNLPEIAALCISPIFLNKSNFRYPPIVEIGPDGMPRYVAESTDASMRASGHVSSGNESYSSGSEARHEGMGRSSSRSMTMYTPSEAVEAASFDLYSHRHPHQIGGDGILPMSATLPMSTASAQSRNRRLSDAPRRRANSRYEPYQQPTTFGNGIMTPLPYPQGPAMDHNPISPPGRRALLGQSRGYVEAEPFYASEQASFGMPRQDAGFFGMNPAEHGSNQGSGAHMGQLGQQANSAEEFQQQGRPQPSFHASHLMPIVPSQPGRDHTGYLGESNLMHVRAELMGVKQETSDIFHFSSRMGRGSWDSNQPSHAAPFMHNVQQPPATSQGLTAISVHSPVNLGGPVYGRFAGSPPNTSSSHDSRHSYVDNVQAPTTGRIEELADGGRPPTASRLEDASYLSRPLSRAEEGGYVGDLDSAGVVRAAPVDALQVHSDPTTPYPHAHRTLQSHAGDAAAGLDSYGRLAGEAQGSSTLYAHPATHLSQGHAHLQRQPVDRQGQDAHNTTHAYMHHDPGMAMPHDAQSRPSNAAQERSRSAPGEEQAFPSRPGTSQGDAFHHQYRDGHGGQDTADGQVTDGLGLERTPIDMVSAQQRLLGLIQQQQQQAQPIPPQLQPQHVTANHPASIAAAATVALSATLLDPNEWNALASTSMVTLDDLRAAFLEQRQQQLKDLESSHRASLREMLFMSQNFDKEEVSGSPWKLGQSMEVAEDDTSEDFQSFLTRHRLSLDKQVSIQDYDMKGPGAIRQLVSRELKTGPVEVAPPPTPTSATAPPTGETSREKQKEIEHQREAALHRSQAVARAAAAVQTRAIAEGVAKIKPLTITTADSQGVRVAPLQPGQVPSFVIESTTPIPPVVSGALPAITAGPESLPLDSVAKDGNATSTIIKVESVDKTDSPSKKASSALDKAVSPVPGLSRNATTQSAGLRIPPSPMVVPTMPEEVPEPQLHPTLQVLAPNPLSVTYAASLRPLPPDPTRRITGAGVGGGAIHHRSGRKVASMTGHSNANSYSSVAAAKIGPAGSGQADLYRWYVRARASPGAGMVGKADKCLLTTDWKVAFNEQRFVRAMARIEKLKAQGEWSFRQPKKQKGPVVRKAHWDHLLEEMKWLQTDFREERRWKMAVAFHLAREIAAWHRARTVTERASFCVPVHRPYRRRTVSDNIEQHAGTQERTGADASSPAPPIVEASQDSEMPDADVPDRAQSESVATSEQKAQLAESQAPGGDVADVTMEADAEADGALTEAVEDAVETADQAASVRAVEMDADGDDDDADADADDVEAATAALVSGEPSKAPEVEVVREPLGKSQPMPALSVDPQQSQPATATSTADPAAEAANGAAEKAPRALRSDPKLAETTLTAELPQQLLATLRAPIFSTNVTTTIVSPAALLESLDPEAAAALLGIEVGDLSTTADLLEPDALSFSKMFPELPLYGGVSLPDPSSKSDRRWDEGSLNQPPRLTHVTKLLDSRPLLVSTLEPSKNRAEGRWLPDSDWIVAAEQSDPLRGVADGADTGLPPLPGSLLFARKNNRASKETANAASGVPPEPAQPDARAALFTWTSDEDSYLMTLAKQYHNNWSLVADLFNSTRLNTATDKREPWDCYDRCKRIQQAADEGKPPPGPPQLPAAAETDKKGDGKDDASASKRDKQGKKVGGKHDGSKRKLRRSNLMEVMRKSAKRREASKQAQQTQQTKKVNLNTHETHAQIKAGPAITPQSLSALKAERDQAALRQYYEQQRAQLAFQQQQQQQQRLLAQQAQAQRMAAQQSGGAGAAAATTPAQAGKPANAVASTGASGPAALSLPPGSTALPQPGQLGQVQQKAAGQLQGQQPQQQTQQGQVAQAVQVPQTQPGQQQQQQQQQVPAQLQSQFQATQAAQMQNLYAQIQQQQRQQQQQQQNQQLGQSAGMGQVRPAVGPLTQQQLATLTPQQQQQYHAQLAAATAAAQQQQLRNQLAAVAAAQQGVQGNAAGAQGMAFQLPNAQAQAQFQLMQQQQQQQQQANAMQANQARPPNMQAQAQAQAQAQAQAAALQMYQQQQRQAAQVQAQAQMRPPQAGQAQQFVVRPGANGIGVQQRPPAVPTGAGPKAQQQARPANANNGNANTAAGMPATIQALQQQLAISLASSNLSPEQINGLAIQLYKQAQQQQAQGAQPMAGATQARPQNQNRPPQQILNQAIQALAAQNHKNQQQGSASNQASPTQPRPPTPPPRSNQTGGNCRSSSISPPRRNAAAPRTGPASQPVLAPVTTAKLTTTEKTTTEMNHADNTRAQLPARGRQSDDLQKPASGQSNNAGNPRHGRLKERTPRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGX0</accession>
    <name>W3VGX0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04817</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGX0"/>
    <dbReference type="HOGENOM" id="CLU_282710_0_0_1"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="447"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="867"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="937"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1079"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="970"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="626"/>
            <end position="627"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1104" mass="118414" checksum="A1146D9B9200BCFD" modified="2014-03-19" version="1">MRKSNVAAASEDLKRKGEKKKKYAAFASSLFQHPHSSQATFCKAKKTRELEEASPSKSPQSGAWLSDDSLFKLGEMLALPRGGLGSMNSNQERTMAFPAPRAAKFDGVGRSTTPPLQRRRASKPVAPLDGDAGDALPVNRVKAVCGSWAAGAPRLSTAGPRLGFTSAFAFAFSLSVSRSFSSSAAAKSPIARAWLAPIRATLPSSRIDASSSLAVLWLALPVFSFLFADALLRALPSQLHRSPYTLITLGASSAQPAAAVRIPHPLLSIYPCRRSLWSLQPTIITTILTVAAHIHIDNVFLPARCFPTTFVDLSTSSSHTPVLVCICSGSTLFSARTSTESLASSRSPSTASAVLPTDRDCSSPSSRSPSRHRTACLAAFPPNRELASRHPATVEPALWLAISPASFNPHRPSAARSPLASPVTMSSASANQQHKNLIGHRIAEGRLELVQVLGLGAYGVVYLARDLHQHHGAYASTSSHQASASLLAAKEGHASGYYAVKCLNKVGLDARQRAFQRREIMLHTMASSHPNVVSLHRVIDDPQDPCVYVVLDYCPDGDLFSMITETQRYMLPSAVTRAAEAQGIEVAFTSERLKMDALIRDVFDQILDAVEFCHRMGIYHRDLKPENILCLRGGAKVVLADFGLATGDKTSSDFGCGSTFYMGPECQGGITRRLTSYSTAANDVWSLGVILVNLICGRNPWKQACPADDTFREYLRNPDFLKEILPISDGINSILKRVFTFRAEARCTIADLRRMVRGVDRLTATSAEIKARQQMARQAAAEAHAARQAEKAAAAAAYREQQRQQQAMVVRHVAAARKPESARVAHHPQVATFDKISQPVVYADDHAGYVAHGEATAIDDDSAAYENYSDSELDSSSCEGDGSFSPSDAPDGSDEGRHQQACVDWSRHPIALPAQDHLDRGAGSNYTSMSDVHASGASVAPSTAARGAMVPMHSSTSMDEREGQSDDCSSRSGSGESRRSSASYTGLPPTPQFVPHSVEENVQRGADYSPTPASKYAAPGQVSVVGGADESLLVGGKASTRGLPARWLQSRWDQDAASLAKVQETSAVLGNYAGGRQYASVPSRRQRPVGLGHQGAHPPMPAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH03</accession>
    <name>W3VH03_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH03"/>
    <dbReference type="HOGENOM" id="CLU_018011_0_0_1"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="515" mass="52003" checksum="6B34662099685C7B" modified="2014-03-19" version="1">MPYRIEYANSNRAGCKGPKPCFGTKIMKGELRLGSLIEIQGSQSFHWRHWGCTTPKIIQNIQEKDGISDPADLDGYEELLPLDQARVARAFADGHVAGEDIPDSARHDPTMIDQADSAAAAATILPPPSPEKQPKKRGRPSKASLEAAAAAAAAEGLPQGSQQQSSQNVAPNAVDPALSQSPPKRKPGRPPKNAAAELPAPSQVVPQVAAPVAPAPKKRGRPPKNPEAAPTPAAPVMQQEPAVASPKKRGRPPKNAAAAPAPQVVPPPQPAVAEPAQPAPKKRGRPPKNAAAAAPASVPVVAPVAAPVAPAVAPAPPAKKRGRPSKASLAEAAAAAAAAAGPPAVQQQTPVYATTAPAPDTAAPTPKKRGRPPKNAAAAQASPLAPAAAPATPVAAPAKKRGRPKKEAADTSMGPITTPPLPPAAVAPQAPVLAPATPPSATKKRGRPPKEKTEGEEAAKRPRGRPKKSDVAAAAAAAAAGAPAAAAPQPSAAAPLVSAEPSSPVKKRGRPKKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH41</accession>
    <name>W3VH41_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH41"/>
    <dbReference type="HOGENOM" id="CLU_1066068_0_0_1"/>
    <dbReference type="OrthoDB" id="10432612at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="261" mass="28312" checksum="1DD36D811E37D56B" modified="2014-03-19" version="1">MSGPRPVSSEAPWRRWPLHPWLLSAVPDDGRRGQGAGCRVNGAGECMVAGDHVLRTVASTQMQMALWASASPSRIWPLLLALISEAKHKAHPKLDGEALVVVEPTSADAFRFDGSSFAPYLSSTALATGAPCGEAPTWLLRPSAINPRAEICTAPVYNFAILAGPSIESRRRARDSAGPKIKEDEVRERDRMWRAWGQGAGKLRRIGVKDTQVARRLFMRAASRQGDQTRAAVQQQPPSSADRCNPPATLRVATPPKAEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHD1</accession>
    <name>W3VHD1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHD1"/>
    <dbReference type="HOGENOM" id="CLU_272382_0_0_1"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="544"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="715"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="911"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="600"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="859"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1137" mass="119345" checksum="096E92C943E918E2" modified="2014-03-19" version="1">MTPTPANCSKAPIVPTPFILQHNRHLDRNAHLTSPSLTPSGSIAYIAMSSAMSSRERFASNAQDAASPRVPFPSSPASRRAGHARSASILSSSSSVSIPSRSSSVIMSPAAVPARSSSIANSPSKSRTLHDARTGLPLTASDLADTIAGLTLAEVPTLDASSTHIDTPETNAQLDASFDVRTPQPLSAPFAPPVLKSTPPHNANCDRNTLISPPLPDLGDRRAELLEIGDEINDAHDAIQLLQADIFSIQEQRHGSRTNQQASSLVPDELDPSTAPQTPPNGALPAGVDLSLMQLDEKLESLSRVMQQLEVRLANLVDPASDLADSEAADSSIIDNDLVSHQSRARRASNASDDSLGSLDDIAFPGFAPALTPLSLRSKYADLCTEWAAIQEDIDGLKKELADDRYLDVFRSISTQAEGMMDSLDKAVSLCHIFIEQIQQDHAAGRLQPSSAPSDELDAEYDIQAKHDQLADLTRTFNVKKAYYFPACQQVFHSLEKGCKERQTSNGTILRRLSDLRSRWRVLRDALAKTERDLKRTDALFRRVRSDSSSSSVTNDIASPATSTSSLPPVASKLRPSASMQTGLGLGTPARASASQKRISPASSSSSRVASGPSRLSSSSSVGSNLSNTPPAAATPQRLRRISATAESLGLHTKPAATPPRSAFSRQLDVPGSSQRTAGGKSTGVLTSPSAFDSPIRNRATSMANAATGAVEKGVLGRSPGARPISMIGGRPAAGGVPASRTAATGTPSRPPPSSFKPSWHDLDAAAGSNRARAPLSQSMPRSQSQVLWPSQSQDSGKQDDTDESIEYLKFGEGSSPARPASSAGQYYRPPSAQGNVGDAKSRKRDSMIPRLSVRNPEGESTPSRPGSAMSQNSTSTPMRYSGASRLSMQTPEPAIVARAQRLSMYARAPSTGMAGMNGAHTPSKRPSKPPPTRRNGALASGRATPLSAAALASLPSAEPGASLKRSSISNLRSLHNGRTTPTASENGSVGGLSAGTWYGAGRGARGVSVGAGSRIGSGSVAGSSYGATGAIELYRANPNDALDVEVAAICNGLGVALERIDPPLPRGVRLEEGPGKDNRAMYEIGGRKVSCRLLELHRPAGSAGARAGSKAKKILVRVGGGWQDLEQWLLGRLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHJ6</accession>
    <name>W3VHJ6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHJ6"/>
    <dbReference type="HOGENOM" id="CLU_049215_0_1_1"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="473" mass="50800" checksum="6E30F4115E3F5ACD" modified="2014-03-19" version="1">MAGSSLGASDPRGSLTEESDFETYLLLLLSDSNLPTGGFVASSGLESFHAHGLLHTIAKPPTHSHDTAGVSSSSATAKRMAPSQAELSSATLSFARSTLHSYSRSSFSFLARVHACVAGYLDSAVQAQLSQNIAGAQGSAIEGEARTALQACLDDVSRLDNSYHSLLLNHVARRASKAQGIALLTLYAKAFAKPIDLERQPFDGSRIGQRHAAPPQASDPHASTQRAEERRIELAAQLVDRLKMDVRRSSAQAPGSAQLGPQGHLPICWGVFAACLGISLRKSVYLHLFLQARALFSSSIRLNTLGPYLAHQIMRFHMRTVVNDIIQEMDDAGCMVIDPHPTSSQTLQPLPAREVETGAYTIEDEPPPPPQVLRPRTGKPFRNTGSMASPAAGAAPAKTGTLRVGKGVLIAVDDDDPHQGWAWDWPEDQDPSSSAHDPEHGFWTTPSAPATTFPLGEIIQARHDQLHSRLFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHK4</accession>
    <name>W3VHK4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_246101_0_0_1"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1455"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1516"/>
            <end position="1526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1571" mass="171464" checksum="47034D923B54947B" modified="2014-03-19" version="1">MHSCAPNSALSQLTDRWMLNCQPTRVLGGSVALLLCCSHTLGPSPSPSQFESKDETDDGSDTDTTRQLLIDLASPSHRLDTTGQDSIMAGPRMSGYEAASPDLATASTSLLPIAPIKPTPLHPLEEDPPLVLQHTRSSTQSFGADRRQTPDDEPQNGMCRLPKRAPDEDAQAARDKLDRIAKAQQAKHNWAKSTGITIAAKAFGRHDRRMRRRAHGASSDDDSSDSALDDDEARGHIGEVKLMITGNPVVTKVFDAASRAKGRLRAQTESPDASPHKEEPHFRFSIGRPGSSLAKRLRGPSITPASEAFSTPAPSPTSEAPRLPSIDAPTTPTVDRPRSRIRPNLGPELLVVDEEGHQHQATQDSEHKRSNRPNLPLSNSFNSQSPSSLISSAPSSPGNRPPLDQRKQPHSSASSFIGGPIHDEPDTHEPEGDLTARTLASPAPSSSASSVSSDDELGDSALASDSDDGQDNMLKIQSLSLEHGETLTKEQLKRRKKLIRREIRRRKANGEPLDDLAQMQGKAGQLGNLVSSRVSKGLHYASSQSRNRRAMDRYSPHPMQLALHTSDLPRSTSAQSAGFDRTNTPFSAIAPSISRGSNAFSQRRESVATMASSRRSSMTGGEDDDLQDPDAAGPTRRFSGVDRSILSSRNSIRKYLHAPNVLKRHRRKKWEAEMDAFERAAEAEANKADPDAELDQMLAKHAQQQAPSDAGKVKYEFDVLYENQRGLLVFGIPKFSPRTLFQWDPSPWTAANGKRSPYNIANAQLPDPSWEWAYHEWYIDMTGDVDEAGWQYSGNFGRRFWPNVHFPHGRVGLPKTGVEGIKEMNARLAEKERKRTEKEEQKEDGGFEALKRTARARSSKWTGSPDAWTFVRRRRWIRLRRRKPLFGAHAGKTPTTEGQEKAASPAQELGLPDLGGKAPLSPGKMGVKPGPSDDENIGESPLGGSDESDLSSSEDDEALYAPAFGGSSGFLPRRLPGGLSNGADPTKAKDPLQRRRARKHAREFTGTIRELKSLLPSIVAMDRKAGTRGPTGLTASASSYKWAMLKINRVDARNPFISWHFVKHRLQDEDMAFAASTLRTMERKYQQRQLAAIRKKGEAQPDVGATSSHPPIPSKLLDASRGVRFGDGEPCTGLKAGNDETSRPATLGLQEPFAQSPAEGHELTREALVEINFARVLRVLRACKVDRQRMDLWKLWLGVITLDSLMETVRREDLVALGLVVPVEAGTEAGMPEAASPSLLEAAHASGGSSFRYRQRAEKARARWRSAVPKPDASDVWDVLERKLDEVLLLFEFQSNRAQLIRLLLTVHEQLHPDHVYRDRSLRANPVELSPAHVHGDAAEMGGPEVGGAFGSRLGGWKRAGVPRLEFFSDLQRILAALPGNDATTNSQYILSQPSPSDEIVAMPMGIHTNPLIDKLEAEAESDAFLEGEHIPSASPVEMMGEGRTERLQAREAARLAVPRTPSPLARAPSVPLPYRNSPLSPPVVPESQTTASSRPESTASAQERAPAPGSAELTPASSSPDADAAGQREHVGKTVTALEPHIGTRPGSRPRPPIPVRSGSVSPVKQREPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHT4</accession>
    <name>W3VHT4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHT4"/>
    <dbReference type="HOGENOM" id="CLU_1461930_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="185" mass="19799" checksum="6D74137A3EE06F9B" modified="2014-03-19" version="1">MLCEQQRGSGSNTLGNGGDRVGSIDGKSIWLGAVAYRTRGSRAAENFVFASRQATPNRNSPGFIDLLLPERRASVDAYTAPQVQSQSGPGEIRDRLETAGVRSSVGGIRFAFGRRTPSKSDTEKRPGRVHDAAQIRPPLRIGQCVLLLDEAATAARGRRAVPQPALSSQHADSAVAILRRLNSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI05</accession>
    <name>W3VI05_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">60S ribosomal protein L41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI05"/>
    <dbReference type="HOGENOM" id="CLU_1038709_0_0_1"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="268" mass="30123" checksum="45BC78435EF615BC" modified="2014-03-19" version="1">MLALPPPILKPSIRSVSVFASSSSHPSALRPRTSDPNSPPHLHHLDLDLSHPSVTIEKWSTFLRRAGLTARASPARSTREYSTDINQHQHSISTAHAAEYKADMEHLWDGTAHGGKQSRLPRHHRCTSPQTHAVMSHSPGQRPERKGSSDISIRDTGRPAHPPRAEEIAAVMVDRIGFRFYDTPHKITQYKTGKASLYAQGKRRYDRKQKGYGGQTKPVFHKKAKTTKKVVLRLECTQCKYRSHVALKRCKHFELGGDKKQKNAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI17</accession>
    <name>W3VI17_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI17"/>
    <dbReference type="HOGENOM" id="CLU_1001583_0_0_1"/>
    <dbReference type="OrthoDB" id="10578474at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="278" mass="30922" checksum="A2389567FE4A9EFC" modified="2014-03-19" version="1">MSLGRTMLEPRAFPPHDSVLEYVLCAAYQQDHVPVLVATAVRKTSDVLPRALPSLLFFDQQSIMVILDWPVRNRLRTNSLRSNLNDVLRPGARSRGAPLPGSLRGAAWDESRTSRLHRSEAPPRLPRRHRHFNASVGSARSWQRSPLPLSQQLPMSLRVPNRHAEVAYGDSMVERASITRRGHQPASTSNGGGRGRCVHDTAIWGIAPLGPPPKDHICTRRDKRESVIRLPWPDQDVMVDNAVDRSRLDFSEPAPAQPQAPSPKPHVPSRKPASRAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIS0</accession>
    <name>W3VIS0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras GTPase-activating-like protein IQGAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000972_1_0_1"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05127">
        <property type="entry name" value="RasGAP_IQGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="120"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="811"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1472" mass="166238" checksum="C1F573CB4D45F416" modified="2014-03-19" version="1">MTVGRARGQRTHSIDATASPLAHSLNSLNLEPTIDEGWHKPARPGRMESEDQEGEIVLPGITTGAEDVAGLHGRIRLARADGPGTMALGRPSATASTLPLTSSSKWMDTQRHLLQAYEYLCHCGEAKEWMELHVGEQLGHVVEMENEMRDGIFLAKLAKNFEPNCVPRIFVHPKLQYRHTDNINYFFSFINKIGLPHFFHFELTDLYEKKNFPKVVYCIHALSHVLARQGRALKVGNLIGKLEFTDDQLQKTQKGLDASGVAMPSFGAVGKALAKEMNIEPEPEPESEQERIDRELRENFDSVLALQTAARAFVARMRFAHRVQAEILRRKEQEARAAAAAAAEAERQRRADEDRIVSRWAPILQAQVRGLLARRHYHRKHAALHTSTRTFVGLQAAVRAKLARQTHVERVKRVHDANNARAIEQFQACARGALYRRRFFASIKALDKHETGVVGLQAHARGRLARRAYEELIYRLADSTEDVIKLQAACRSALAKQKLLATIQGLRRSNDAITQVQAQIRGVLARKDHVRMRSALQKVEVKAAVGGLQSFARAALARRKHQEQKKQLDFVTPDVVGIQAAIRGMLVRQEYAWWRNHLDQSEPVAVHLQSLIRGTLGRRRFFARLRHYHDHMDKVVKIQSLFRGRQQGEQYRSLTMGKNVPVATIKNFGHLLNDSDADFEDEIEVERLRKLVVQAIRESRTLESDVSELDTKIALLVKNKIGIEELIKAKNERGLLGQRDAAAAVQKRNSVLVAANDPFADHALDRASRRKFELYQELFYALQTRPEYLARLFARVGKIDMADRDKRQMEKIVLTLFGYAQKAREEFLLLKLFQRCIDEELGLVSTVQDFIRGNAQFVKLVAQYNRGTRERKYLQDVLSPLVHDIMQQDGLDLETDPCAIYRATINQEEMETGHPSRRPLEVAFNDALADPMARTIFIRHLQSLRATTEAFLSAIVASTRKMPYGVRYIAREVFRALQAKFPNEPEGALIKVVGHLVYYRYLNPAIVAPEGYDVVDSIVGPVQRKNLAEVSKMLTQIAVGRLFSDDNPYLQPLNEYVSHAAERFTKWLHAVIDCPDAEMQFSADEFLDHTVQQKPVIYISPNEIYSMHVLLTQQLDHLAPHADDPLRVILGELGAAPVSNTQELNSARDSEITFELVSRMATLQDPEAETKALFVETKRLVLSLLKVQSGKTLVDVFVAPVTDKEELQWEEIVSLEVAAERQRQRGQRPPGIPLYGGAAGARLEDVRRLSFAELKARTLENMLQLEQLGKVSRANKYQDMLNAIAIDIRNKHRKRIQRHNEKQAMHATLKTLGEKKSYLEEQIHSYHSYIDASMQTMQGRKGKKRFVLPFSQQYFHLRSLKQNGGKVPKFGSYKYSAAKLLEKGVLVSIDGVAKSAAPDAAGEVSLTISSDQAGVFTIEVVNGPHAGLASDLRIEDLLEAQFNNATSLNVLDGTACVNVNLLVHLINKKFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ09</accession>
    <name>W3VJ09_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04277</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ09"/>
    <dbReference type="HOGENOM" id="CLU_013819_3_0_1"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="13">
        <location>
            <begin position="581"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="401"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="711" mass="77079" checksum="1C0ED40E2CD0EB2D" modified="2014-03-19" version="1">MAARKLQTEIDKTLKKVGEGVEIFEDMYELLQRSNNSTQKEKMESDLKTQIKKLQRLRDQIKTWLQSNDIKDKKPLLDNRKLIETQMEKFKAIEKEMKTKAFSKEGLIAAAKMNPRDREKAEISDWLSTQVDELARQTEAAEAEIETISGSGKKKKGSAKDERASQLENANDRRNWHMSRLEILLRMLENGNLDTERVQDIKEDIAYFVESNMEEDFEEDEGIYDDLNLDDGEEAFGLKENDDLHSNHDSTAGMDDLSFRDLKDTPTKQRRDSLADTHTSTTSTNKDTAILTTSSSTSNTKDKDSGSSSHAKKEDAAAAAAAAATAAAASSTASQPAASPAPPAAKKTTKKASQEAVAVPKEKAVPTANFAQAKAPAASPSGVLSPPKAPSAAPLPPIRYAAAAAAAVASSATASTNDHAVSSPSAATAPVANDSTDANGAASANGATSALSAAVGAPSTPIKSGVDAARASDAADKARNSNSNSSSSNNNNNNGEGASTGMSGFEPAQLAASSAAASVVQPAGGGAGTAAQQAAAQKEAGTEARLPTSLTDLVSSFESAKQKSLQREANSGLVHKSLESSFMNVPEAVDSDRPRYYVPRNPFPTPSYYPQTPAGVFDNPALYAKFDVDTLFYIFYYQQGTYHQYLAAKELKKQSWRFHKQYLTWFQRHSEPQAITDEYEQGVYVYFDWEGSWCQRKKSDFRFEYRWLEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ27</accession>
    <name>W3VJ27_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ27"/>
    <dbReference type="HOGENOM" id="CLU_1038710_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="268" mass="29031" checksum="E4632EF1301FAE62" modified="2014-03-19" version="1">MRSAFAKPGGAEAAAVTATRLEMRITISRLKGVNAQIPALHRLPKPPLGPRRRAHAARASPQTSAAVVRTLGIPQRQAWIIIIVVLLHAWSSLLAATRLRSGLGWPNGFCKAAELLLPSALATMDRLAATFTRLNRDLASFLFFGVHSSLRHGILQLLAVHWPANPASQLQQTSASSRSPTLPAHSAALPSRRPAQTAWSRHSLCFEPCRRLDAVARKSSIDALHPTTTPLDLRAFRFIYTTSSSASRHVVVIPAANPVYSAHLNRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ46</accession>
    <name>W3VJ46_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heat shock protein Hsp88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ46"/>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="764"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="764"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="856"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="98915" checksum="A5DFCD5DDBB5A14A" modified="2014-03-19" version="1">MSSVVGIDVGNASSKIGVARARGVDVIANEVSNRATPSLVSFGQKARALGEAAATAQTSNFKNTIGSLKRLVGRTFQDPEVQKVEKNFINAELVDAKGEVGVKVRLAGEEQTFSATQLLAMYLVKLRDTTSKELGGAGVSDVVLSTPLWFTDAQRRAYLDAAEIAGLNPLRLLNDTTATALGYGITKTDLPEADNPRNVVFCDIGHSSYQVAVVSFSKGQLTVLGTAADRNFGGRDFDRALLQHFAEEFKGKYKIDVLSSPKATFRLAAGCERLKKVLSANALAPLNVENLMEDIDASSQLKREEFEQLISPLLERINVPLEAALAQSGLSKDQIHSIEMVGGSSRVPALKERISAFFGKPLSFTSNQDEAVARGCTLACAVLSPVFKVREFSIHDATPYSIKVTWDKAADVPDEDTELVVFQPNNPIPSTKILTFYRKENFDLEAHYAAPDQIPEGINPWIGKFSIKGVTPNAEGDHSIVKVKARLNLHGVLNFESAYTVEEVEKEEEVPVAADPAAMDTDGDKDAAAAPKTEVRKVKKLQRKADLSIVSGFTGGKDASVVSEMKEVEGQLYSNDKLVIDTEDRKNALEEMIYDQRSKLDDRYKLFVTAEEKEKYLAALNAQEEWLYSDEGEDATKSAYVERIDSLQKIGGPIQFREKEFQERPRAASALREAINKYMEMAQGGDEAYSHISEDDKQKVIEKCATVAKWLDDGLYKQSELPKNADPKIVSADMLKKKDEVIYFCHPMYVYSSRSLPVSSAASSSAAKSTDMTTSTSRASSSSGTSGTGTDPPALSVDPGAEEPSEGEESCVSSADSASAGLRLPSELSDFEAGPLGPDSGCGVTSGNARVHPRSETPSSGSSRARSSEASMSKIKPRVDTTQAPTPAKEDKKEAEADKNAEADKADGPGEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJB7</accession>
    <name>W3VJB7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD binding dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJB7"/>
    <dbReference type="HOGENOM" id="CLU_039338_0_0_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="82"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="2">
        <location>
            <begin position="235"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="50421" checksum="FFB2006CF8E16589" modified="2014-03-19" version="1">MRSTLALRQLAVSASRASSMPGVRTAVPRATSSVATALQRNNASVRLPAGARGMASDAATEFDPNAPTAMDKMEPPKPGADFNVVIIGAGNINFGSDEGPWNHSFRLEHKLGPRLKVVALIDPSAARADAALTVKRNSFVLSAYKDTVVYPTFADYVANVTPDKRPHAIWVGSPPAFRGREQPGRDLEKKLVEAFPDVGIFIEKPVSTGPVQDALKVAQLLEKADNLVSVGYMLRYLKVVQKMKSILEENNLKVMATNARYIMAYEHTAKLDWWDKSQTCGPIVEQATHFCDLSRYFGGEVDLSTVAAHSLEWFEPAGELSKIPVDESKVEPDNRIPRITCATWKYESGAVGSLTHAVALQGFNYSTEIDVLADGYSLRLVDPYNAPALYFRRPGDDHEEVVRYQNDDPFFSEVSNLIDNIEKGKGAAPILSSYDDAVKTYALTWAIREASEKSAKKPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJL3</accession>
    <name>W3VJL3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJL3"/>
    <dbReference type="HOGENOM" id="CLU_031996_2_0_1"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="415" mass="47899" checksum="E6802A37D8FCAF3B" modified="2014-03-19" version="1">MHGVKRTPKTATTAEARAARAAKDAAKLRAYLDIERTFFEHRQQSRKDATALAHTTTLLTLNPELYTVWNYRRDILLHTFTQPADDDAPSATPDVFDVFGALRTEAAQSSTDADEARLVRNRQLLDDDLSLTEHALRAHPKVYWIWNHRMWCLRHYPALSADAQWAWRRELRLVERMLELDARNFHGWNCRRAIIDHLALAVVSSAQCDALAGVESSHASLTALLTHPTIVAAERDAAKDVKKELMRLAETELAYALRQIERNFSNFSAWHLRSQLLPCVWVAQRLTPAQEEERLDKELELVQQAMYTDPADQSVWFYHRWLIDRLTTPSREDRSRLRAKLGDEVRAIDELHELEPDSKWCAMSLAHLHTLLAQLDPAHADEHRASAQHRLERLVELDPDRAQRYRDLLAGRARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJN0</accession>
    <name>W3VJN0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJN0"/>
    <dbReference type="HOGENOM" id="CLU_008220_0_0_1"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="912"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="66"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="554"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="938" mass="104471" checksum="FC8670349FF40B7F" modified="2014-03-19" version="1">MASNFSRSGLMTQATQAFHAISSSTFAAGARLSDSPSPAAALSASYTNEQSNEHSVVTGQGTLQFHLAQQIAESMFLKARRVNLVRDGHDNDGIFLRAHDNTYAAYPMDAYRGVAMQSIKKLRCEAAIIISSEIIDSALSTLQPNQTELILTPKQRVQVVKSLDHLWSCRKGQGAAFIQAEAIMVVWTEDGKDLLDAAVSFQNHVLDYFESLRRGSYVSNLLQHSSSNASIYRGIGHSRNGSTASSAASSQTRLPSLSSHSDLGHAKLAGLTPRHRPSPSLSGSSDEKKGAFGEKSGGDMDSSLEAGMVPELATTKRPVYSLAPFLTGLSLGLNLLFSGIFLRRIIVTAVTLNNYLYLLAILAIPFTMMLTQFFTDNIFGCIAQILLPYGNMKKNSLYYSGEKPIPLPIDVALPSITIQVPVYKESLEGVIAPTILDMKKAMKTYELQGGKANILVCEDGMQLLDEEEQQKRREFYQTQGCGWVSRPGHGRNGFVRAGRFKKASNLNFVLDFSFDVQQLLDGGRAKSYDEALEMALQARDGVAWAEGDVRLGDYIFLIDCDTRIPTDAFLDAASEMETSPEVAILQHCSGVMYVADHFFENMMGFFTDIVNWSISWLVACGATAPFVGHNAYLRTSALLQVSERDAKTGQLITWSENSVSEDFDMSLRLQLQGYVVRWATYSNLGYLEGVSLTPSDELNRWQKYAFGCSEIILQPLRYWVTKGPLTPLFKRFITSDKCSLSQKITVSSYMFSYYALAMSLPFAIAMFLVVGLMDNVTSLYIVDSFKVWLSILVVFSAGGTVARLLCFLRSRQKGFLHALKRQFVYFWPMIVFFSGLPYHILLAILAHPIEYNMTWAATQKDVQETSLVDEIKDILSRYWHCYLVMTSFIALMLLFGTNLLSQEFCIYGFNLFWPGSITIFGHFMYPILLSPVFMRFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJU2</accession>
    <name>W3VJU2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJU2"/>
    <dbReference type="HOGENOM" id="CLU_047036_3_1_1"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="203"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="392" mass="43736" checksum="CDAC41DD631C38D1" modified="2014-03-19" version="1">MDLVLELADTYALDKVWATALPALPRAFAKDPTALASLASASSASNFSHLLGLKDAASWAASASTSALSPSSWFENTVLKNAVASALGGEAVNWSALQSVSALPRDNVVRQTVSLLVLTYIGILVLYFTFAGLSYKYIFNKEMEKHPRFLKNQVKLEIQSSMRAFLPLDFLTVPWFVLEVRGHSKLYNSISDYGWAYAVLSVPLFLVFTDFLIYWVHRIEHHPRLYKHVHKPHHKWLVPTPFASHAFHPLDGYAQSLPYHIFPFVFPLHRVVSIWLFVFVNLWSILIHDSDMICNSPLEKIINGPSHHTLHHLFFTCNYGQYFTVCDRMGGSYRAPRQEDDPMLAVTAASEKATLAQKKAVAKAEAAAQGLSDDQSDASSSGDEGVVIKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK72</accession>
    <name>W3VK72_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK72"/>
    <dbReference type="HOGENOM" id="CLU_1300175_0_0_1"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000004">
        <property type="entry name" value="Probable 60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23312" checksum="1F75122257EF4AC0" modified="2014-03-19" version="1">MLVTCQHFRQGRARPRSDLAGSTSRRAGSKIPTAGQNPHSLAKTAPGRRAGLAIEKTRSLQERTDSWSRRQLGGAGNARTCGRPRRAEATKARCSPSDPPSASTGTPHHIQRSVKMPQQITDIKKFLEIARRKDASAARVKSTTRADGKQVTKFKIRCSRFLYTLSVDDKQKAEKLKQSLPPGLNVVEIGKPVKGRKPDRSFASSYTTIIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK97</accession>
    <name>W3VK97_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative peptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK97"/>
    <dbReference type="HOGENOM" id="CLU_048223_0_0_1"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833047" description="Putative peptidase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Putative peptidase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="291" mass="31633" checksum="793F89C393CB059E" modified="2014-03-19" version="1">MQIKASYGALLALVSTACAMPTSFLQARSLQVEEKMDATWRIHESCNGTQRAQIQRGVDDMHKLASSSIAHLVNHPRDAFFTTYFGEEGDPASVIGYFEQLISGDKGGALLRCDNPDGNCQFADWNGHWRGNNATAETVICDLSYQTRRPLEQVCGFGFQLARDNPSTYFGADLLHRAFHVPQFVNEKIHHYADTYADCLELAKTNSSAAVTNQHSLQYFALDVYSRNMVKNGCVGKVEDTHDHNHATTSAAAPAQTQAHTSSSAAPSATAAPASSDCHTHADGSVHCGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKB7</accession>
    <name>W3VKB7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKB7"/>
    <dbReference type="HOGENOM" id="CLU_036006_0_0_1"/>
    <dbReference type="OrthoDB" id="2555040at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="60524" checksum="A710C3C0DFEF158A" modified="2014-03-19" version="1">MAAAGGGRARPPRARAARTAESRGSTSGRRRRGEDEEREDGDPTNDVGDSEDLAEEDDDAQAEESEDEDEDDDDDNDDDDEDEDDEDGDADADEDDDESPFKFLERLDPNWLTRRSYPQAALSAQPSSAIGVDGRSPAGGADDAEFYAAMIQMLTHVLGSSDSIGWASQATPGSQLAPSPFAHPQSSPAQTPNHAGASHAGPSRSTSLRSKNELSALQPLIQALIARLGKDQQVSRRPVGEQDLTALLQTLMEQQQRQQQQHSQRQGSDGQAAQVFPSSNYQFAQPSLATQAASDSALGRSHPQTDHTGVGFGIAAQDAYRPLHFADLDFEDEDEDDPDFNPDLNPDLPLPSAWSLAVRDVVASEKSRAAAAAVAASHLGTPSGSQTPAARRGSYREGDPHPHAHLFPHPTSFATEADRPPAREPSTHASTSVGEANEGLTTAEHIDTHATAEAVRAASATQSEPEQGEQSIPRKRGRKPVLEPGEAQRRRAQRNVEYQRMRRQVKKAEESEQSEAVLELRAEVKMLRAEMERLRDENAMLRAQRELDRLQRSNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKG1</accession>
    <name>W3VKG1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKG1"/>
    <dbReference type="HOGENOM" id="CLU_073511_0_1_1"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000021">
        <property type="entry name" value="Density-regulated protein related to translation initiation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="172"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="291" mass="31151" checksum="8B6CC0C1578F3C8D" modified="2014-03-19" version="1">MDGCASSMAVPVTDVRSGLQPAAKGEAQPRSAADCQKAAPPPKQLTPAVCPPCTRTPVTTFRRPCKMADIENEAGPSVPTGPQPREVVYCAVCTFPPEYCEFGPSPSKCRSWLQEHQPALYSQLWSEEAISSNLANLTTKQAEDLEREAAKKERKTVAKEERERAQMAASRIVLKKEARTKRKVTTSIIGLHLFSPPLPALKVVAKALSSRFATGASVSKSVQNPGIDEIVVQGDVADDVRDLILSRTKPFHELPSDAEGGPSEKNIAIEEDKKTAKKAAAGAPGAAPAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKH4</accession>
    <name>W3VKH4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKH4"/>
    <dbReference type="HOGENOM" id="CLU_288872_0_0_1"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1070" mass="115670" checksum="09009C9999951F43" modified="2014-03-19" version="1">MHTSTRRRLAEKRAATNTQQGRKKRQSTRVRHIGLRAVGVAKGGGEVSRATPPPPDFEPPFVRRRPSSAVIPPAPWAIHQRHHQHHRPPTTNALPQPWAGETEHSLLLLVSTRPGTALLVFRTRLPTTWANMSSSLVEDWSEGDFDLDHTALRTEHLSLHDDHDDNPTAAHADDFSDWDHDEDQDASDEQTDTIKLSNIAGSALKQMLEASKASASSLPSADLHALDQHQLVHHDADLARLDIMRFANSHDDLNTCSTASLSTSASTSYRSMMGLSTDLTDPDSPHSKHGTRNNTTTTTTTSCSSSNRARSDLGFHSSEPDDAIDELDFELAPNMDNLSLCSSLSRARSNTSLSHVSRDLWDEEPALGASATSHQPATSSKSISGESDADDEHEDLLDGLDLQGSIFEPQPNPAVQPAPLLKAKLEAMLDLKRSGRHPDPYQTSAHVTDSDSGIAAGLVITDDVDLSPSRITSRGLSNTRPNPSYAQIANSRLSAQTVTSGGHDERQHDSHASSSHQHRHQHNRAPSGEAASQQSKGFRTEPRGPRRSLRFKRSTSDLQTHMSASSANPGPSASNRSQNRGSQLTRKRSLPSMRTSPPAPSSVNVAAVQLGAHTIAVRQRHNSGASASSSVSRIRSHGSSRLTDSTAASRARAAETAADQLARLHRDAKAPARPSTPVSIPTRSSHNPPPRISVSTRSKTRAERQGLSGESQPAARLLKRSAPYASGAELDGIDDLTTSTSPSVKPIPLPPSSTPANAGRGATKTDQGASQSQRGGKSKRGGRRHPKSKPGLIRSLGVGGSPTQKTVKGMRWNAQALRWEGNEAVLRDFDQVIQSSTRPALISQITGSSTSSRLTHAAGYTSPISPESSTLMNSIASGARVVGDMLFDPVQMRWVHKSGNEEDDVFAQFDEALDEGDASHDAAGLGVDAEGDNTLRARRARSIEAFSQSSNPWTRLSAREPAATASDDEAYERSLNRKHDQAIRRALSRGAFAASVGIERDIWDACVEADKRHALEVGGWLTPSAPYRSRMRTRSHTSDRAMTLDEIDRPRPHLYYLEKIAKSIARSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL19</accession>
    <name>W3VL19_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_03795</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL19"/>
    <dbReference type="HOGENOM" id="CLU_034001_2_0_1"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="39"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS62219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="519" mass="55062" checksum="75AFE7D5CC604FD7" modified="2014-03-19" version="1">MPRLPSSASSSDAGHTSSTYAAPVPSQPSALDDRKISILTLNVWGLNYISKLRIARIKAIASHLTAPSTPHYDFVCLQEIWYESKDWRFLRHALAARYPHSKFFYSGAFGSGLAILSRWEIIETRTHPYSLNGQPIHVHHGDWFVGKACGAITIDHPRLGMLDVWNTHFVAAGGEDGPEHRRSHRIIQAYEFASLCRNSAAQGRHVVCVGDLNSTPPSLAIGLLKHVGGMYDSFLDSHPQLPEHATSLDAEAPPPGLGRRGSAAAGPDPQRAIDELGVTCDSPLNTWTAGKKLDARATRGAGKRLDYILYRGPIVRPEASALAHSASASSRGRLSCASSSVVFTHRVPGVECSYSDHFGVESVFSIAEDADAASVQGGGRVDQARVLGAALSALAGGFSASRATQTSHFYAFGAALLLAVALIVASIFQPLAGVNPLFVLLAVVAGWAGTTMLYSAVVWGEWEKRTLRTVMETLELEIGHLRRGIHANTSAGAGAGAGAGASTAAAGAVPEAVREGPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLA5</accession>
    <name>W3VLA5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLA5"/>
    <dbReference type="HOGENOM" id="CLU_013482_0_0_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003855">
        <property type="entry name" value="Chromosome 23, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="951" mass="100278" checksum="C8E68C53745E8C96" modified="2014-03-19" version="1">MASIHDPSLPIPPSSPLRIPLIAPTCSTTHTVQIRTFLQASPPHRATAQPTSFGAILLALLPAAPLSPPPPHALFAPPRLITSSVTPLPPQVIHLDPPPSSLKIGSTPPTLATTSALPFLARPFRLPTVASGPRLPSSAQPSSLFASTHGSICTARLIQYTFDVPRTFNTSASPSASRPSHLALALAIGSSFPLRLPARHSPYPASSRSVNLNSLRIRARHLAPASGQHLPNLSFAFLRHLLCASPSSDTPPSLGQPTPKGKFDVEANAADNLLSATGVAFKRSSFANDRMTAQVVLGTMPHPFPSAFSSPVATPTKELQFPSLPPFSHQTSTPASAESSSDAKHSQTQSSTAGNASSNTPFPGVATAVAESSAPRTYRGPDARRSSRPRLRSLQSLNSAPASPSLTEQDSGRAFISTSRFHTSHPSLGRAPSRNAVESLQPLAESSVAAYSTTADRPSARSPTSASHPWPASSHTDTAALPPRARRSSTSPKLDSGLSEFGQMGAPFSAHASNQGFLRRSHTITTGISSAAQKRADDSSSHRSPPPNAMTYGPSSGRQAPKLNQRRQTVSNVSPTSLDRAAPAQQIAGVSPVPSRTLSYAQQHTPHANGASAISVSSPPSRIRERGTLPNNQLEAKVVILGSQGVGKTSLVHRYTSGQFSVASTPSTIGASFLTKKLIVDAVKVRLQLWDTAGQERFRSMAPMYYRGSHAAVIVYDITSMSSFLDVRAWIEELKKNMTTDLVIHVVGAKLDLAWSQRQVELDYARATVKSWLQPYQTQAITFPTPGFANVSDGSPGSPTRPSSRLSGLSSLAIGSASRLAAFQRTSSQAATPASAVAGGLKPSSFGSSAASSGSAASDPGRDAAADLDAFGFSLSWDVVEVSEVSAKDDRGIEEVFLAVTKKLVERRSQIEHDRAERERNSIFLSSHDADQLLAGADQPAITPNSWTCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLE8</accession>
    <name>W3VLE8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLE8"/>
    <dbReference type="HOGENOM" id="CLU_544138_0_0_1"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="73"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="445" mass="49862" checksum="5E23C035BC79ACD2" modified="2014-03-19" version="1">MPFLALPSDDSQLRYADDPIVLHYLVSTPECRTFAAAQTHASKLAASLSSSSNLAASEARREVKLDARYPIVLFLPSECFSVAHLFADQLSDSTLSAHFNLVAVDPRGHGLTREVPIRDPTTRKYDLDIKAADVLAFIRLLLSPYQPANGKQGEIRWAKGIHILACSMSGLVAARMAAQWPDTFTSIMITSPILELESPFMVESFQGIKELLTESWHQQHSQRSNDVRLPGEVVQGFTFRWAGSETIPAHIASYLSRTWLERLVLHHQGLEAARDWWFDLYWLRKPMPEAARCTVRCDLLVVEGDRDLPYDRNVADDIAALFPNARSVHVHKVPRAPFLLSVKRPSQLTDAICSFLGVHPDKAAYSEDASMDALMALEEDERFELVKVYAPQLVPDSDSHADSDDDQDEEQAESDTDPEEAFDSHTLRTKRADTLHANRAHAQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLH2</accession>
    <name>W3VLH2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLH2"/>
    <dbReference type="HOGENOM" id="CLU_456475_0_0_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="582" mass="65306" checksum="A05D7562EC8D6FD9" modified="2014-03-19" version="1">MVVANFSTFLGAQNGPKSLSIKLRGWGSKIRALCLLVAIVWLTRVVLYFEPTLSPMFGMRVRALDAAAHDIWTDYIATHPVEIDDRYGLREMGFRAHAYAEFARTGQIGRLERIEEHLWSYAPAVAEIRRTALRIRPKAAEPVEDLVQARVSAQLKKSGRLSANQTAALLTAAELEEAAQGGKSRGIVMVVSRYTALAALQTITVLRQLHGCLLPIEIYYHTEDELPNGLVDMFKTLGRVSAFNIDTLPYFNSDLEDDAGRYPGLKVTWERQSLALLASSFQEILIVDPEVVFLQNPSLLFSHPTFASTGTLFFRAKAKPVDRASQYLVSFLKRQIDQGSPSQQLAESAFFSHGIGARMDMDVVVLDKSRPGVLSALLMNAWMRRKMARALFWGSYVDMMREALWLAFELSDIEYAFENTWPGAIGRFDGEWDDHSPQLCSPRTLQFLSPQAAHQKLSRKYFSLFQSHDSRSRKSVASKHKDNAAGEKPFWFHGGFLVPRQTGEIYYSPNVYARNAPPYTTVDEDNSDSDSCLYGATLNRLKGTIVPSTLQKAIEIAHEAFITYRPTLMHYAPLPAPIKSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLJ0</accession>
    <name>W3VLJ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLJ0"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08296">
        <property type="entry name" value="CAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="338" mass="35898" checksum="B3D33068D5D9D552" modified="2014-03-19" version="1">MSSLPKTYKAAVFEKNGEPLVLKDIELKHPEEGQILVKVEACGVCHSDALVQAEAFGPLPRIPGHEIVGKVVEVGPHVTKWKQGDRVGGAWHGGHDGTCRQCNQGLFQMCDNGQINGVTRDGGYAEYCLLRSEAAVRLPAEGNAVDMAPIMCAGVTVHNGIRKMNITPGEVVAIQGLGGLGHLAVQYASKMGYRTVALSRGTDKKDFAMKLGAHEYIDTSNGDPAEALQKLGGAALIVATAPNPEHISPLVGGCRALGKLLILAPVGDVPVNSIAMITKGISVHGWPSGHALDSEDAVEFGERFDVKCMCETFPLAKANEAFEHMMSGKARFRAVLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM44</accession>
    <name>W3VM44_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM44"/>
    <dbReference type="HOGENOM" id="CLU_054426_0_1_1"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="298" mass="32072" checksum="667AA29F87C6A4DA" modified="2014-03-19" version="1">MTAVASSSTTAASAAAPSSSASRLEPLLLVARSTKPRGAAAAKLIHQAISTPGAYFFSELFDIPGVAELITSATESDGQLRAASYLLQLFAYGTYDDYLQLLRAEAIEAVSAEEVQKLRQLTLLSLARNSKSLAYGDMHAALGIAHTRELEDLIIESVYAGLITGRLDQVQSRFEVHHVQGRHVAPPTHTVLPSLSGNEASLQHIFSALQTWQATTASVLSSLQSRMDAVRSTAAQAETARTEHHQALLQNLTNAQHQLEAQQKKSKPNAMDLDEDSRTDARKKSTSSAARGNKRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM77</accession>
    <name>W3VM77_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02461</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM77"/>
    <dbReference type="HOGENOM" id="CLU_026582_1_1_1"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="386" mass="43335" checksum="9183FF4CBBD30D96" modified="2014-03-19" version="1">MTDTAPRSVLDELCSPYLPFDATSPVWSDVTPVAQAESSSPMCPILYNADYSSAMDVYRALVSSNAPAASVPLEGIELSTRALALTAHLIQLNPSHFSVWHYRANILLYARELEQRPGGRASVLRAELDWLDNLAHANMKSYQVWQHRRIVVAALGDPANELQFSAENLARDAKNYHTWAYRQWVLAHFGGLSLPTAVGDAVESPGKAQFPQLWEGELGYVDELLREDVRNNSAWNHRWYVCFARFGISAHASVAKERVEAMRKTIAFEKAYARASILGTPNNASAWTYLRALHNSVPHELRTPMSEALPWVETLVSTPKEAEADATVDIMGRSPVGALEWCLDCITTTTPDAEQRAEHLVKRLITVDSVRKRFWAYRLKSIRRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMD1</accession>
    <name>W3VMD1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02533</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMD1"/>
    <dbReference type="HOGENOM" id="CLU_055194_0_2_1"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="55"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="209"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="294" mass="32799" checksum="31DA80AA7FE71950" modified="2014-03-19" version="1">MSRPEHLAPPEIFYNDTEAQKYTANTRVQTIQAEMTERAIELLMLPEHRKPALLLDIGCGSGLSGEIITEHGHEWIGFDISPSMLEVALEKETEGDLLLADAGQGCGFRAGSFDGAISISVLQWLCNADATSHNPAQRLSSFFTTLYSSLSRGSRAVFQFYPESDDQVKFIMQFATRAGFGGGLVVDYPNSKKAKKFYLVLWVGGEMMVGPNGQATKQTLPEGKTHDHEEAAASNGVKYEKRRLDRDRRGSKKKRSSETAKEYIVRKKQLNRKRGKEDVPLDSKYTGRRRKGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMG0</accession>
    <name>W3VMG0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMG0"/>
    <dbReference type="HOGENOM" id="CLU_001201_0_4_1"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08199">
        <property type="entry name" value="EEVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000015">
        <property type="entry name" value="3-dehydroquinate synthase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000018">
        <property type="entry name" value="Related to 2-epi-5-epi-valiolone synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035872">
        <property type="entry name" value="EEVS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF3">
        <property type="entry name" value="2-EPI-5-EPI-VALIOLONE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="6">
        <location>
            <begin position="97"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="7">
        <location>
            <begin position="210"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="465" mass="50445" checksum="E75F50FBCAE650A3" modified="2014-03-19" version="1">MACCGGAISSDMRATVTEVPASANATGPGYNIQGYEDLKYTYSFVDNVFDQKKDDLASYYQKWGRVLCVLDENLNELYGPSIKAYFSAHNIKPTLHVFKGGELHKTMDTMLGFVDAMDSFGLIRKEPVLVVGGGLASDVLGYACASYRRSTNYIRVGTTLIALIDAAISIKVGINHKKLKNRLGAYHAPMHTFLDFDFLKTLPIGQTRNGTAELIKILHCTDKYTWNLLAKYGEDLVNTAYGRNATGPGAKELKAAADEICRNAIKGMLDLESPNLHEIGLDRVIANGHSISPTLELAPFPPLRHGHAVCIDMAWSVTLAHMRGYIGDEDRDQWFRLAGQVGLSVDHPLLTDELMREANEAIKKTRDGLQRFVLAKPLGTCVFANDITEDEFVKSLAVHKAYVKKIGRGDGVGLDAYADAGDLGADPEALLKERKAEAARLNGAHKSEAIATKAAPAAATAAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMJ5</accession>
    <name>W3VMJ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TFIID subunit TAF5 NTD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMJ5"/>
    <dbReference type="HOGENOM" id="CLU_005884_0_0_1"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="9">
        <location>
            <begin position="188"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="568"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="616"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="658"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="766"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="897" mass="93001" checksum="5F90D6D60F2C56A8" modified="2014-03-19" version="1">MPPASSAAPAAAADKATNNDTTRAADSTPHTPKDASSISLPTASTSTGGGSAAAAAATAATAATAAANDAAGGVFSSPDMTAAVLAYLQKRGFDRVEAAFKAELDALASGATPEKAAAAAADTLGRSPTVGLEDLAAKNAPRTTNDKDGDKDKDANANAAAAAAADADLTIAEDGGVSAAAAQALLLDPTDRARGFAMLKQWCQGSLDIYQPELLPILLPLFVHSFLDLVLLGHGPAASALYSAHVASFLPTHTALLSQIRSLALPSHIQTDALAQRFRSERYVVKMSNTVFSLLLGWLTDGGGPVSGSIGGLEEAEAPARRGREAMLKIINERCRIQVLAAQPYQIDAAQQQQQQQDGDTTMQDASATEGGGDDQDSSSRARTASVRPSEAPSGAAAAATEVKLAGATGPDFSAGLLAAGIDDLPPQAPTFRTVDVKREVQRIRDARKRIRLDPSLATSGATTFTSGVRDAAGNALGEAGANAARVAALPSVCAYTFHDADDGITCSTFSSDITMMAAGFEESFVQIWSLKGEKLRAVRGNPNLSSIRDSKSLARQREAEAYSTRRLIGHSGPVYGVDFDPVGGSASAPRHLLSCSADATARLWSLDTYSALVAYRGHQHPVWDVKWSPLGTYFATASADKTARLWSTERVNPLRMYAGHLSDVDCLTFHPNSLYLATGSSDRSCRLWDVQRGACVRLFVGHQSAISCVRISPDGRYLASAAAGNGTAAQLAGVDGLDPSSQGAHMNDTSISLWDLASGRRIKKMWGHSERVYSMDFSADGSLLVTGSQDCSVRCWDVRAVGGARKTPPKGSLEAQQASAAAAAAAMATSALAPPSADQLKNGSLASAALAASQMGADLANASADCIATFHTKKTPVLDVHFTPRNLCLVAGVYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMJ6</accession>
    <name>W3VMJ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000380_3_0_1"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="8">
        <location>
            <begin position="2149"/>
            <end position="2283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2388" mass="272961" checksum="7E0A3356F0BEAA02" modified="2014-03-19" version="1">MSGPPGYRGPPPSAPAAMRGPPPGMPRSGPSSAAASSSSRREPPPLTAEQLQAKARKWQQTQSRRFGDRTGKSAFVDTGKQDMPPEVLRKIIKEHGDMTNRKYRQDKRVHLGALKYLPHAMMKVLENIPMPWEQLREVPVLYHITGAITFINEVPRVIEPVFHAQWATMWIAMRREKRDRRHFKRMRFPPFDDEEPVVDYSDNLLDVEPLEAIQLELDEDEDGPVIDWFYDHKPLISNSAHVNGSSYRFWNLDLPQMATLHRLGRTLLSDASSAGDRNAFYLFDKKAFYTAKALNMAIPGGPKFEPLYKDTDGFDDDFTDFTDFRKVIIRQQIRTEYRVAFPHLYNSRPRAVHIGVYHEPANVYIRSDDIDQAFYFDPAINPISARTLASTGAFRDTYDDGSPVLSHEDAVFGPGVDGDDELPDEVAFSLPDEIEPFLQDAPLENDLTADAIALWWAPKPYSLRSGRTRRAVDVPLIQPWYLEHCPPNQPVKVRVSYQKLLKSYVYNSLHTTKQKVHKRTNLLRELNNTKFFQNTSIDWLEAGLQVAKQSFNMMNLLIHRKGASYLHLDYNMNLKPTKTLTTKERKKSRFGNAFHLVRELSRIMKLVVDAHVQFRLGSIDAFQLADGLQYLFNHVATLSGIYRYKYRSMRQIRACKDLKHVIYYRFNAAGVGKGPGVGFWAPSWRVWIFFLRGIVPLLERWLGNLLARQFEGRGGRSGAQSITKQRVESAMDLELRAAVMHDILDAMPEGMRQNKVKTIMSHLQEAWRACRSNTPWSPNLPAPIENLILRYVKQKFDWWTSVAHQQRARIARGATVDKAAVRKNQGRLTRLFLRAEQERQADYLKSGPYITSEVGVAAFTATVQWLEARRFSPIPFPSLNNKHDVKHLVLALDSLKEAYSVKGRLNQSQREELALIEQAFDNPHETLARIKRLMLTQRAFKEAGFDFFDTFSKLTPTYDIEPIEKITDAYLSQYLSYEADKRQLFPAWIKPSDSEPAPLLVYKWCNGINNAHDIWDTSEGQCNVLMETTLSKVFEKIDLTLLNRLLRLVMDHNLADYITAKNNISIVFKDMSHVNSYGLIRGLQFSSFVFQYYGLVLDLLILGLQRANEMAGPPNMPNGLFQFRDTATETRHPVRLYTRYVDRIHILYRFTADEARDLVQRYLTANPDPNNSNVIGYNNRKCWPRDARMRLVKHDVNLGRAVFWTVKNSLPRSLTTIEWEDTFCSVYSKDNPNLLFSMLGFEVRILPKLRQEDVDVARDGVWPLVQASSGERTSTAFLRVSEEGIANFSNRVRALLMSAGAAPFSKIANKWNTCLIALMTYYREAVVNTEEMLDLLVRSENKVINRIKSGVNSKMPSRWPIHILASPKELGGLGMLSMGHVLIPASDLKYSRQTTTGITHFRAGLSNQEDQLLPALYRYITPWASEFEDSARVWQEYAQKRKEANEQNRRLTLEDLEDSFHRGLPRIATLFQKDRTILSYDKMWRVRQEFKKYQIAKSQPFAWTNQRHDGKLHNLNQLRTDTIAALGGVETILEHSLFAATGHPTWEGLFWEKSSSFEESMQQKRLTNAQRSGLSQIPNRRFTLWWSPTLNRSSVYIGFQVQLDLCGVLMSGKMPSLKISYIQLFRAHLWQKIHESVVMDLCQVFDQELEALSIETVQKETIHPRKSYRLTASSSDILLFASYKWPMSRPSLLTDSRDVMDGSSGNKWWVDVQLRWGDYDSHDIERYCRAKFLDYTTDNTSIYPSATGALVGIDLAYNIHSAYGIWFPGSKPLIQQAMAKIMKANPALYVLRERVRKSLQLYSSEPTEPYLNSNNYAELFSNQIIWFVDDTNVYRVTIHRTFEGNLVTKPINGAIIILNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEETIALVRSLPVEEQPKRIIVSRKGMLDPLETHSLDFPNLSIVGSELQLPFQSFLKLEAIGDLVLKATQPQMVLYSSYDNWMTNVSSFTAFSRLILLLRSLHVNQEKAKIILRPHPGVVTEAHHLWPTLTDEEWIKVEIQLRDLILADFGKRNNVNVNSLTSSEIRDIILGMTIQAPSVQRQQMAEVEKTAEAQQQVTATQTRTVNVHGEEIQTVTTTQYENKVFSSKSDWRVRALSATNLPLRCQHLYVSNDDIRDEVGSLTYVMPKNILKTFIVNADLRTQVAGYMYGVSPADAPSIKEIKVIVWVPQRGSNHRVELPDTLPEHEFMLKDLEPLGWIKTSAVDVPHLPPQDVAVHARTMAAHPEWGASTICITCAFTPGSVSLSAHSLSVVGFEWGRKASDADVASAAGFNPATMVDKTQLLLSDRILGTTLVPTDRMWNYGLSLSAQWTSSVKYGLVLDRPAAFWDELHRPHTFLSFTNEQDAADDVADWQDAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMK2</accession>
    <name>W3VMK2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMK2"/>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_1"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000014">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="10">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="168"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="480" mass="52867" checksum="9420EA957C6FACC3" modified="2014-03-19" version="1">MANSDFLNKAIEIVQKAIDEDVKQNYQEAYKLYQNSLDYFMMAMKYEKNDKLKDLIRKKFTEYLDRAEKLKEHLAKSSEDRNRAAVGANGAEKGVGGSTGGKKDGGDDDDVDPETKKLRAGLSSAVLSETPNVRWDDVAGLHTAKEALKEAVILPIKFPQMFTGKRTPWRGILMYGPPGTGKSFLAKAVATEAKSTFFSVSSSDLVSKWMGESERLVKQLFQMAREAKPSIIFIDEVDSLCGTRGEGESEASRRIKTEFLVQMNGVGNDETGVLVLGATNIPWALDLAIKRRFEKRIYIPLPDLEARKRMFELNVGETPCALDSKDYRKLAAQTEGYSGSDISVLVRDALMQPVRKVTGATHFKKVLAPAKRKAKQEKAKNGSADTGAHGDAAQQDGDAAAAAAAAADEEVEEMKEFLTPCSPGDPDAVEMTWDDIEGEQLLEPKLVMNDFLRAIQAVRPTVTKADIEKHIEFTNEAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMK8</accession>
    <name>W3VMK8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="8" type="ORF">PaG_03593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMK8"/>
    <dbReference type="HOGENOM" id="CLU_042432_1_0_1"/>
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    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="7">
        <location>
            <begin position="137"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="344" mass="37695" checksum="52B9ECDCE6720503" modified="2014-03-19" version="1">MLGNTSVRSLARARAQVCQAAVRSFASTSKVRLDSPARSGDGREAGPSSVHASEIEHFSRLSSQWWDEHGEFGLLHAMNPARIQFMREKLDEVWGYERALQQVAPAISSVPTSSSSARNPLSNLGKTRFLSGLDVADIGCGGGLLSESLARLGARTTGVDASASNIGIATTHASRDPLLSRPHSLGGSSLTYLHTTAEQLVAEGRQFDVVCAMEVLEHVNGPADFMRSLDRLLKPGGHLFMSTIARTPLSWFLTIFMAEDVLRLVTPGTHTHSQYINPDELKRFVQNDLKWFAKGSKLPQRMHFEVRGTAYLPWKGTWSLAAPESALPATQCNYFVWARKPLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMR6</accession>
    <name>W3VMR6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMR6"/>
    <dbReference type="HOGENOM" id="CLU_093253_0_0_1"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="268" mass="29076" checksum="B5254982A19E8EF6" modified="2014-03-19" version="1">MVAAITSRAAARVTPRLRGALADSHIGSRVMISTRIPANQVGRASSSKVAVAPKHRASGFCNTIPQVTRNFSSSSSRQGSSSGRTTVKDPEPQTGLYYHPTEISVARGPGEAAETVEGWAVSFLSQPSANDDAAIAFILPTTSSSSQDSEPADFVRANPDRIRINPAGWKIMHDVLKNEVVPNDDLLKFEASTRESGWAHLTDLRHPLMPGRIATPENIIASVAFTDGTLKVDSYEINNSYRLVTGYEGPIQMADSWIEKLRSRFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN10</accession>
    <name>W3VN10_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN10"/>
    <dbReference type="HOGENOM" id="CLU_009710_6_6_1"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10289">
        <property type="entry name" value="GST_C_AaRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="59"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="9">
        <location>
            <begin position="292"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="50116" checksum="59D0A108D332B424" modified="2014-03-19" version="1">MSGQRARQLITAAYAQYANDAKHLALASRSLCRLGAAHLAQFAPTPAQSFCAETFSTSPSTSQSAIQQLQGDSALPLTDLADKLAGLTGKSTHIFGADDKAKAATNEWLQKLDKADEHQFVSAEGLKALDAQLSNVTFLASNEPTVADLALFASIYPTVSKLQPTEQHAAPSVARYVSHLSNLSQVAKAANAAQLGFSSFEPAYESMPKIERAKPEDLKKAKKASKEAAAASAAAATDGEKKEPSKPQQQDQQPKKEKKEKKEKAPKEAKAGGGGGKKGGAAAAAADTTGPIPSQVDLRVGKIVSIEKHPDADALYLEKVDFGEADGPRTILSGLVHFVPIEKMQNRMVIGVCNLKPVAMRGIKSYGMLLCATHKDGKDGGVEPVYPPAGSQPGDKVWVEGFEGREPEAVLNPKKKIFETIQPGYTTTENKECAWVGALPDAADPEADQKPRLLRTEKGVLYSENFVGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN89</accession>
    <name>W3VN89_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03792</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN89"/>
    <dbReference type="HOGENOM" id="CLU_001715_0_3_1"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="235" mass="25969" checksum="6B614219491AD402" modified="2014-03-19" version="1">MSTSNWASTPPIPSDKRPIVLSGPSGVGKSTLLKKLFEEFPNSFGFSVSHTTRDPRPGEVRGQSYHYVTRDEFEALVQQGAFLEHAQFGGNRYGTTAKAVADVSTEGVKGADGSTDARRAILDIDAQGVKLIKANHPSLNPIYIFISPPSFSTLKQRLTGRGTETAESVHKRLTMAANEMEYARQMGAHDWIIVNDDLERAYTLLKKAINESLQKGDDDQMPAKDDEEQQWLSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNQ7</accession>
    <name>W3VNQ7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nad dependent epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNQ7"/>
    <dbReference type="HOGENOM" id="CLU_079104_0_0_1"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="305" mass="33675" checksum="4EA3113D2DC8518C" modified="2014-03-19" version="1">MLILIAGITGNIGQLAARYALQLGHQVRGFSRSPDKLDPPVAQGLEGFIRSSSYYDVPALDRACAGVDAVICAYSGTPELHLDGQLLLLRAAERAGIKRYLAASHNNDWRKIGMGDVPIYDPIKCFSIHAALTSPIKPLFIISANFLDVFFGGEGQGDFTPAVGGPWDPKTREMHIWGTGDEKWYFTTEADGAKWAVEVVTSANAERGGFVTICSMHVSLNEIRHIYEATTGKHINVVRRGTVEDLEKTVLEKKSNATHWGDWLRYALVLHNTKNIWGLDVEEFHGFFPSSPSSLEEWLKAHPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNT5</accession>
    <name>W3VNT5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNT5"/>
    <dbReference type="HOGENOM" id="CLU_150777_0_1_1"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="107" mass="11776" checksum="828D56CE233688E0" modified="2014-03-19" version="1">MKVAPSSSGVSALKALQCKVFGTTYNPTQARTGAKVLRQRLQGPSMLAYYPPTVNLRAIEKLAPGLGRLKDVREIQREKDVERKKMLGKGPPKKGEGRRAAMKGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNT6</accession>
    <name>W3VNT6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNT6"/>
    <dbReference type="HOGENOM" id="CLU_393361_0_0_1"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="701" mass="75607" checksum="C1971A0D12A491E0" modified="2014-03-19" version="1">MSSTSCVSPTSNTLPRRPSPHLLVSEPRTTLFDAASSFQTLIEAQACISSTHSASSELLSIAESRFPPSTLPISTLTNIVHASSTSGSATPSTASSSKSSFSSASSLSTSTSAMGDAAAATAPGLDLLGILAEEVDWDPQQRGSPGSAQLALVGHTLQSHHEAKQKSWATHILGSLGLVEPDSARKRSFSSLTAPFPAELREASVKAHIPALLAEPDAKPARPCAAAKPTSADPLNTMVLTKRTALFYEKLYDRLCPGIVPRAYIYPKLGRRSHDQDPTFAGLALSISLLGMLGLTLPRPAATEDGQRPFAMPAIPRDKHSKSKGKRETVEEAARIIEAVLALRLSAPGGGAGFGQSPTLETVLTSFFLSVALYSLDDAADDDEWPSLCAWRDASFFRFCEAITLVKILGFDQLAQSDPGEQTSDEASVVLLLARAERWWAEQRPEYLCQLEVGPRAAPARKRSRSEAREEAAPVKRNKQETLAEPLAEPLSLLIPLGFAGVRKALLQKFALSMDCWTGRCRRGRECRLASHVAVRIHDALGTLENVRRRQDSDDPILVDLARQALRAQLWIACLNHGLVDPRAEAPLRPDQPLHVALDTLDLLEDLHHLLRLQRSTSAVADAVREALHTVRECVALLPTGKFATHPFAFEQIQAGDEGDSPQPDSPSSDDGQPASNSTTITRAAQSVMDNLDRFLQRQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNX6</accession>
    <name>W3VNX6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNX6"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002709">
        <property type="entry name" value="Probable iron inhibited ABC transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="82"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="394"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="629" mass="69771" checksum="88DE100A48F02FB8" modified="2014-03-19" version="1">MPPVSASKAKRQAEKAAKAAAKGEKSSKSSSKSGTTNGTSETPMTNVSANTSVEELNMKKLAIATERNASGVLTSDKQSRDIHIDNFTMSFHGRLLIDTATINLNYGQRYGLLGDNGSGKTTFLAALAGRDVEIPEHIDIHLVSGEAEPSEVNAVDYIVASAKEKVAKLEKEIEDLSVADEIDEVTLELKYEELEELDPSTFETKAGMILHGLGFSPEMMKKPTKDMSGGWRMRVTLAKALFIKPHLLLLDEPTNHLDLEAVVWLEAYLSTYNHILVLTSHSADFMDSVCTNILDLTPQKKFLTYGGNYSTYVRTKEENETNQMKAYAKQQEEIAHIKKFIASAGTYANLVKQAKSKQKIIDKMEAAGLIEAVWQPKPLRFNFEDVRKMPPPIIAFSDVAFSYSGKKEDYLYKDLSFGIDMDSRVAIVGQNGTGKSTLLNLITGALNPVEGTVQRHAGLKLGKYSQHSADQLPYDKSPLEYMESKYKDKFPEKEIQFWRAQLGRFGLSGAHQTSPIRTLSDGLRNRVVFSQLAMEQPHILLLDEPTNHLDMGSIDALAQAIKEFEGGVVIVSHDFRLISQVAQDLWEVKDRKIVNLSTQDVSIQDYKKKLAKNSAEAIERAKLFAKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP82</accession>
    <name>W3VP82_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP82"/>
    <dbReference type="HOGENOM" id="CLU_291550_0_0_1"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="689"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="824"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1082" mass="113504" checksum="B4985F7705C9EE51" modified="2014-03-19" version="1">MAQQTRTNRRQSRLRPRSEQESHVETALASISRAPLASRPTTAQRAVVPACQAGPSRFPDHQPILSPSRRHTKAQAASRGSQGFRGSSAKSMWLLRSILVALLLPYVAALPSSYVSDPRRSARLEPGSARHLPQPRNYQPVARSQLKVGRDLASTPAQPGHLDRDRSSTADGKRRELDPQDVLRSARLRRDEVFPSVVAIDAASDESAQDDSGRTLTIVFEKADGTESNVTLTPPSRRWGQTATFMPAHNIVLVVGGQTSISGDITNDVYALDASQLTPSGQNTSASSQSWQRLSSEGLPAHAFAAATSAVDPADGSEKLWIVGGVTQSCAQDAPAYVWSAPVGNITAGKWTAVYTDDGVTPSRRRGAKAVTITSANATSVMVSGGTFDASTCATTTGTYAGVDMWTESSAMASASSLVSASAETAHVGIDITGSAYASVQSLALDSRMRDFSLTDYTTVVLPANGTCGEKVLFLGGKSQAGQMAPLDRFWALDMATGNWEHWNATGLIPSGRMGHTAVVTPDGKVIIHGGYLEDPSEFTTENDPINEVFILDPHQSPARWDAAVWTSESSAPPALAFHSAVMASDVMVTSFGKLSDGPLSDYSSQSFIASGQNAASPVHFLDTATLSNAGGLTWSTSAAGVAEARQAVANTVAAGQVSAPTQSEAAPAQQAPVAPAVATEPVQPAAIAAPSEEAKPEVAAPTPAAAPSDDGDKAGQKDGASDAGANSNHTGAIAGSLLGAAAVAAAIGGIYAYRKRKEAAAYNLGRDAGNRDAEADLARFHGDEEKGDRAPPVSSLYLRGDGAVAAAAGGAGWSARLKRAASTLNRSKPEGGAADDKYTSTPKPLMTLGNIAPRRNAGAAEPQHETVAKRDLPDHFITQLADDESPFVFCDNEPLGRGKLLMPTDDGRGELKLLHTNASHASLATVGTIESNAAASHFSYPYLSGMHRGSSPRSYNSEHTTGGVQRVRVILGTPESCYDKMHMSPGDVVSPYHLPRNPHASPESLFLNFDLDHAHDDDLDTNVAVDGVSVAPQDIRTPVFPWDTPAITAPAPAKIIEPTGNGRTMSMLRTQPTSLHVTNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPF4</accession>
    <name>W3VPF4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPF4"/>
    <dbReference type="HOGENOM" id="CLU_880345_0_0_1"/>
    <dbReference type="OrthoDB" id="2555180at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="316" mass="34256" checksum="369D87BE2C3BB647" modified="2014-03-19" version="1">MRTRLLSRLAHNPASGCAYNIINVPPVYSAVAGVAILPSVSLATPIPSLDHPRLFHAGAVGTSSNMIRINWTAPWACLLCILVSVANVAGLPLSYHFPSAASAASAAAAVAAPAATMPKNHLPSWVVVKLATSNLPTTFNNRFGHTRHGSGTRIPAWHTGPWDQAWSLWDDVSTKIAGTIPASKLRKRALGFNVEREIINHLRPDDWLQRTKDFSRSLFGLKLHVTPQQYASVASRYRSQIPASAYRSRIAASSYRSRIPASAFPYTRPNSFAPRPPSGPVPSVHPVCIQRDIVSKASRSAKSSDHTPYHASLLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPM5</accession>
    <name>W3VPM5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPM5"/>
    <dbReference type="HOGENOM" id="CLU_1378671_0_0_1"/>
    <dbReference type="OrthoDB" id="2556515at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="198" mass="22282" checksum="83452A68F5E641B7" modified="2014-03-19" version="1">MFVKQLLLVLAYGPPDHVCFTFLAGDASNVDVTITKGAFAYLATDVLVKDDNIHEKQCLSLSQRYSLDFTIEDTSKCFSMYPSASQLDIAPSSPSKSGYAEAMSYLDDGLAPTSLMSHLAHRQQTHTQRSYDDAEQWHTDSSTASESEFGSDDQLALQREWEQQVDQFKLLFQIVVCPFVGKFFGRKFGYFSAFWGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPS1</accession>
    <name>W3VPS1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPS1"/>
    <dbReference type="HOGENOM" id="CLU_003041_16_9_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="164"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="338"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="634"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="744" mass="78882" checksum="33C223581993F708" modified="2014-03-19" version="1">MSYGGYSNGPSRGGYGGGAPRGGPSSYGGGGGGYGGGSYGGGSSSYGGGGYGGGAGGGYGGGYGGGFGGGDRMSNLGANLGAVDWNSVDLVNFEKNFYIEDPRVAARSDREVQDYRASKQMTIQGQNVPKPVTSFDEAGFPDYILSEIKKMGFSEPSAIQSQAWPMALSGRDLVAIAETGSGKTIGFALPAMVHINAQPLLKPGDGPIALILAPTRELANQIQVECNRFGGSSRLRTCAVYGGVPKGPQTRDLQRGAEIVIATPGRLIDMVDAGKTNLRRVTYLTLMFSATWPKEVQRLAGDFLNDFAQVNIGSTELAANHNVKQIIEVCSEFEKKGKLIGHLETISQENGKVIIFTSTKRVADDLTKYLRQDGWPALAIHGDKQQQERDWVLAEFKSGRSPIMVATAVASRGLVSQSSSSHIPPSALPALEYGVGAWTEASQLQRWRASRSRSSVSSCSAFLPVARILPRERIQAIRPPKQVCTVRIGVPKHSTVPQVLPESASNSSSASHQEKPLINIAFKFKEIAASTSAAAAAPVPPSFGVSALAASYVRCCWYRQPCCRCDELAVVPRESVAAQILPSPFGRSISFAISVVRGDVSHSATGRILTARLAASAVALLAPWRLRQPLVPGNVKDISYVINYDFPTNTEDYVHQIGRTGRAGRTGTAYTFFTPENSKSARELVGILREAKQEIPREIEEMGRFGGGGGGRGFRGRGRGRGRGGFGGGGRTGANSFAVGNSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPU4</accession>
    <name>W3VPU4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02009</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPU4"/>
    <dbReference type="HOGENOM" id="CLU_394365_0_0_1"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF15">
        <property type="entry name" value="MIR1-PHOSPHATE TRANSPORTER OF THE MITOCHONDRIAL CARRIER (MCF) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="124"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="225"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="12">
        <location>
            <begin position="398"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="651"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="699" mass="76888" checksum="21F71F21878B9D3D" modified="2014-03-19" version="1">MSAASTSSAGYKMEPGALTSNFSVGDYARFFASGALCATITHGAMTPVDVVKTRIQLEPKGSKASMLSMGRQIIASEGPAGLLTGFGPTAVGYLIQGGAKFAGYEFFKKKGVDLAGSHEAAQRYRQAIYLGGAAAAELIATTLLTPLEAARIRMVSERGYAKGLVSAITRMGAEEGIRGFYAGYAPILCKQIPYAIGQFVTNEWAHTVADSAISKEDRAKYGKAGEVTIQLGCGMVAGVAAAVLSHPADTLLSKINKGGGGQGSAMTKLIRLAVETGPVGIWAGLGTRVLMTSFLVSGQFLIYAQVGQLIGKPPGIEIRSDSEKAKAVWSVRINFVRLTCKCRRKFPRARNPKIPPPDSPLQPRNPRSTLHAALLIFQATSTTSSLFLLQCKQMAGMDPFQVRLRFVSALQRVNASLPTIQKALSFVVEHAATLHPELWECITDELKSASINRRINLLFLIDAIFTDETLSATVRSVYTPHLERDLYLIFDLAVPEDRWNALLNLPAATKMISSWKSRFVLERGLLEDVEKMLEVRRAALYAMSPEKRRKTVVEAGDMQRRIEEDRERHKRLRERAWILPATAYTSQSLFGTRPEQLDPTYLTRTQTASPRAERDDVDGDRVWTTQDLDFSHMWEETSDFNDDDVEAIQEDLKLSWANQPPPTQPTPQPPIHPSRAQERFSASRPPREPASMRHPQRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPY0</accession>
    <name>W3VPY0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPY0"/>
    <dbReference type="HOGENOM" id="CLU_017584_4_1_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF12">
        <property type="entry name" value="AROMATIC AMINOTRANSFERASE ISS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="84"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="560" mass="60357" checksum="CA6F008A271BE440" modified="2014-03-19" version="1">MLVVPSRTIASISRRTTLRPGSSLQHASLRAMSTRSAPGYGFNPNLHLRTIDPPVQIGARWAQSYPSTSSPLAGADVLPHFPLLNLAQGVPGHPPTQALLDRIRFEGLPENCSAPAGHTHGYGPVFGDAKLRQAVARDINRVYRTPGKGDRHQVTEENVGITAGCNLAFTAVATAIAGPGDALIVCDPWYFNHQMTMTAFGIQIAGVHTKPPHFYPDLQMIRALLASDNRTSTKTIKGVVLVTPNNPTGAIYPPDLIRDIAVLCKEYGVALILDETYRDFLLTGSDGDGPAESSSLAASAALPHNFARPHDLFEDAPPGLAEKSWDPDWDWRSTVIHLFSFSKSYAIPGHRLGGFVAHEAFLQQTVADSNGAQKTVFGPTAKALDNFQVAPPRTDTQRAVAWAIEDATQLEWRGQVASELRVRRRAFVEGLSRPVPPFLNPDASGLAGPESDASLAKSPEQWGWKVESAGAYYAFLRHPFEDVPSDRVAQALAELVGVVVLPGAFFMPSEAETKGDSAGSRLRVSVANVSTEMLAKLPERLAILSELWHKKGAGWGVAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ36</accession>
    <name>W3VQ36_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ36"/>
    <dbReference type="HOGENOM" id="CLU_028051_1_0_1"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000009">
        <property type="entry name" value="Related to CDC36-transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="454"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="630" mass="65534" checksum="C7A3E5271BCC7E14" modified="2014-03-19" version="1">MGLLLSAHHIRISLTRLIRTLSPKGPASSILLAPHPTSAPAFGHFALVKLCYDRSSASQLFYLLLGHAETRLPHSNPPGSASGSPAPGLNAAMYPYLQGGGPRMMGSFMGMPQSQQGGAGGFPFGGSGSNNSTGAASLASQLAGLSGQSGGQTQGQGQGGELNLSDFPALGAGQQGGQGQQGGAPGLGGLNNPLSSYATQAGTTGMSSNLRSGAPLRNFNQDDFPALNQSGTAEGRSGDDGFPHGVAEQVSAAAALQHQHQQREQHRQSLLGSVVGGARPDASLSAARGGFGEPDRNYATKLGAGPPAPGLGVQQQTWAPPGSVFGGNAGAGPNQLNGLQRSSSPSSARSPLSSVRNAASNLGASSPLTESGVARADGLQGVAGSNSTMGVAPTGAMAQTPAQQILTSPADRFGLLGLLSLIKSADPDLSMLSMGMDLQTFGLNLNSSDALHPSFITPWSENNMLASSRVEPEFTLPSCYNVQPPPPAQSKIASFSDETLFFIFYSTPRDVLQEVAAQELYARNWRYHKELHVWLTKEQGTEPTQKTPTYERGTYVFFDPALWEKVSKNFHLMYEMLEEKVPNQAQALAAQAAAQQAAAAAQAAAQQQQQSPSPASQQQQQQQQPQQQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQC5</accession>
    <name>W3VQC5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline iminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQC5"/>
    <dbReference type="HOGENOM" id="CLU_043739_2_2_1"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="111"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="393" mass="44629" checksum="550C05C44F3182AB" modified="2014-03-19" version="1">MTRLRALNLARAYHLSTSTSALLLASSRPIPRGTYSPLLEKHRSYSKNAMAKLGLHAADVVDYTEAARSLSGYKTTLRQPYPTIEPFETGRLEVDSRHTIYYEWSGNPNGYPIVALHGGPGGGVWSEERRWFDPAHYRILLFDQRGAGKSTPHADLVDNTTWHLVGDIEKLREKFGIDKWHVFGGSWGSTLSLAYAQTHPARVSALILRGIFTLRRSELEFFYQNGASHIFPEQWQTYRDGIPESERNDFITAYNKRLTSDDSEVRLDAARRWSTWENATSKLYIDANNLAKGEEDDWALAFARIENHYFINAGWMEDGQLLKKENIDKIRHIPATIVQGRYDVVCPATTAWDLHTVWPEAEFHMVPDAGHSAKEPGIANHLVQATDKYRSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQT1</accession>
    <name>W3VQT1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gtp binding protein rac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQT1"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="193" mass="21504" checksum="9C831A7EE0EFD122" modified="2014-03-19" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVSLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPPSFENVRTKWWPEISHHAPNIPTILVGTKLDLREDPETIAKLRDRRMQPITYAQGNQMARDIHATKYLECSALTQKGLKGVFDEAIRSVLAPAPVKSKKKNNCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQW0</accession>
    <name>W3VQW0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQW0"/>
    <dbReference type="HOGENOM" id="CLU_031404_4_0_1"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="466" mass="50635" checksum="36498BCE698EFA48" modified="2014-03-19" version="1">MQLDDKARDGLLPLSSQGPSAARGSLKGRCKALVCTLAVALLTLAWLHPATLDRAVGCIRQPSIDSRCTSSDLSRRCKNPLKHAEHLLQSHPLVDGHVDVPVIARYRYGNKVAEIPFGQPAFPNGSFPTSGHVDIPRLRAGKSGGFFWSAYVECPDAATVGDDFEHAGNQIGVRDTLEQLDVIKQMTDRYHHDFALVGDARSARKAFKAGKMISFIGIEGAHSLGNSLYALRAFAALFSSRAPGPVRYLTLTHTCHNAFADSAGQHPPRWNGLSPYAKHLIYELNRLAIVPDLSHVSDQTALQTIDVTRGPLMLSHSAARALNDLERNVPDSVLHKLADSGKDHVVMINIYPGFIGGEGDLDQVIRHVDHVSSIVGRDHVGVGTDFDGILSTPKGLEDVTKYPDLVAALVERGWSDRELAGFVGDNVLRVLEAAENVAAKMHRNGAQPDNTSWDDVFRPHAQHGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR11</accession>
    <name>W3VR11_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR11"/>
    <dbReference type="HOGENOM" id="CLU_164170_1_0_1"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="84" mass="9180" checksum="A90DDE6B05DEF77A" modified="2014-03-19" version="1">MTVAASVLGYAGLGFITRCYALGIQKRNIFDNLGGHAMMMTAFGALGYYVHGLEGRQLELIANKKEQILKNRERIAAASSKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR43</accession>
    <name>W3VR43_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR43"/>
    <dbReference type="HOGENOM" id="CLU_984101_0_0_1"/>
    <dbReference type="OrthoDB" id="2536866at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="286" mass="32359" checksum="4BAB077998C792C1" modified="2014-03-19" version="1">MTLKSNFEEIPTLLAPPSYLDSTATDDQVSEKDLLHPRTNIAPRYTAWKLVLEAFIGTAYRAAPDDLDEEERRATALREVLCNVRLVSRLLYSVSMTLLRTRFFPEYLDAIRATVYSTNLSRQSLDHPCRETRVLDHYISYRINRRFLASQSSLLLNDDDAESDQRQVSQDLFKWLQPQTYIEDEIGKALDAGATPSNGVQFGDLLVRFQFTRASITLPFSVDAGSSRSAASAPTIVRKECVAVDRASNEPVFVTAHRLLDQLQSLVFVRKTQSGKAWYELVGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR85</accession>
    <name>W3VR85_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR85"/>
    <dbReference type="HOGENOM" id="CLU_021539_0_0_1"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="614" mass="65347" checksum="60CD70F92EC3A790" modified="2014-03-19" version="1">MSARPGLSAASMTYGMAPPMHPHHLSHAADATSSLPPQSYAAHQQQQQQQQPQQQMSQYGASQMGSNFAYSQGFYGHPSQHHPNEVQSQQHASAYYSHPTSSPQMDPSAQMYAAHQMNHPDMMAGSQFQGHHPDLLAHQHGYAALQGAGIRPKRKQVKNACINCQKACKKCDEGRPCGRCVKYGLVDTCQDSARKERRRGIKRGPYKRRATTGSQPTNPALSVSGPMSYGRDGHISPSSRSDGMLAGTPGTESSFSSPAFGTQALAPRPPMPLQMPSNGWQPSNPSPIGDDRDGLRARYGQSMASNQQSYYGYEQDAAHHAYDRSSSAPATQPGSMLSPMGRFPNSSTSQSSTSQLPSLGSQASANGSYLGGVYGSGAGRMGGMSNGSTGSLLSPPLHSSASSTSFLSASSAPNGLAHHRLHSDSSLATLSSNGASSSTMSPRTPLNGPGSEPPLLSPSGNKMSGFAPPQPTVPTASGTFLQQDTSRPFPLKMPKPATRGRSGTGSSYLDQPQQQQQQQGYYANNLAPINVKLPMQHHQQQQSQPQQQQQQQQPPQFGRSSPYMAVQSLDDRRQFLSNTTPRMDLSPNAGMMPIKSERDVGAPPPAPAGSLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRJ4</accession>
    <name>W3VRJ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRJ4"/>
    <dbReference type="HOGENOM" id="CLU_016786_0_0_1"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF292">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="220"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="448"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="94246" checksum="E65EB07E6469042C" modified="2014-03-19" version="1">MSSSAASSFAALKAQRDARRNPLLAPPSAGPNDTADPTLDATSPGAAHAAPAAAAPIGFGRPSQPQPQSQPMPMRSAAQPTPLGGADDSRAPRPHAPRNKPEPGAAGSRVRLPDIQDLELRFDAISSERALFYAPLPKNGPSPADFRTSSAASAFSPAGGTPRSLSGSYSYSYSQLLSSSFSAPGGWAAAGISACRPGDVLLRLRPEVAVLSTALLEQRCSACYSSPSPADASNATAGANKLQRCSGCKVLRYCSAACQRRDWPSHRDECKALKAIQQLHTYRSALRQQRRLDQRLADRFAKGQGGSAPFAIGSFQDNDEVMAAATATGEPHDADSDADSDEADADAKRGDTSPVDRLRLPSSMMRALARWIWARSRIGTGGKDKASGDTGDLLELCSHRERYAPEELQQQAQLALHLAQYLTAHARAAATFGPVSRGEANLDEMMQPEAEFSQGDALRALGIESATELLDLVCQFSSNSFTLTDSDLNPLGVCMHASMAMLNHSCAPNAAVVFPFGGAAKSGQQNWSDGEDAKVMQLVALRAIEPGEELLISYVDVADAYEQRRSALKKRYCFECRCELCRKSQARRAPAQPFAPPSHWVDPRTAVGCAHRCGGWIDGALLESSEAHAAKCNKCGSAAGVSASDVAQDREHTRDALTRASRLLERNEAEAAWNQCATVLPMLVERYPPSWQPLFQLLRLSTTCLIEAGSNALSQHHVEGPNESAAMYCFDEAVRMQMLFVAGTQTSNTPIYAKGHPARAIAIATLAKLVLAQLDHVARPPSGSAQPVLPDHVAPNATVCQAAVEGTNARDGQTLSILRDPPSVPDEMRVDLAKQLLVQAVEELDIGFGRSNQGGRTGHEMRTALNGMQQELQLLAQTSAMSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRL0</accession>
    <name>W3VRL0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01709</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRL0"/>
    <dbReference type="HOGENOM" id="CLU_004415_0_0_1"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07651">
        <property type="entry name" value="F-BAR_PombeCdc15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000045">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000312">
        <property type="entry name" value="Related to Cell division control protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="53"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="627"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="833"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="949"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="483"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="673"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="850"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="960"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="987"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1084" mass="116292" checksum="73858519EDB276E1" modified="2014-03-19" version="1">MPSDRRSSSAGSGHSSRSRAERASGSMGPDGGEAGRRIAAEDEYIRQELSEATSFCNAFWGHNDAGFDSISARMKASQRTLDELKSLYKERADIEADYAKRLAKLARQPLGHSDTGALKAAFDVVKLELDATSRTHSDLANMIKKDLEAAVVDFANRTWNARKAAQANIEKLHKHKQTQEAYVNKSREKYEQDCIKINGYTAQSSLVQGKDLDKVAYKLDKAQATVSQNDKDYQNFVRALKDTTLKWHAEWKAYLDQCQDQEEERIDFTKSNLWNFANAVSAVCVADDESCERIRVSLENVDTPRDVQFFIQHAGTGSLIPAPPEYINYAKGQAPPARPVYHTARFQRNTTRPTQLPIPQQPPQSQQPSPSAGVQPLQSHHSSQAPSPQPPQPAAQPVVAQRNAQPFQEKPVPPQPATQSFDSPQRQFEPDHRQQTSALPTTDSASAPYATQVSPDPDLGHGHSPSRPVDTQRRMSAKNFLARTSSLSQSKSPKSQSSSRPAPPAALGGATSSNHQQPAAASASNADDDDPIAKALASLRMRPGGKSPGLGRRDSLSAEQKPPAPFAQPGQIVHNMPPEHRAHSPSPSMATNVPPRARSPSAAFMQAPARAASPLPVEEVVGQYGQSFPGERKSLSRQNSVASRAGAPASEAPRSPSKHQQDQGFAGVGARGRSPSPQPWSRPTQQQQQLQHHQQQQHAAQSPRAPAPSSDQPKSGTLSRRQSNVPPRSTTPLGIALDATGSVTHDQMAVDYMRRAGSVPPQQQPPPQQPPPPQAAAVPPAHAQQPARPPSVVHANYQPAAPHHQAHASVSSQYSMAPGATSAPAIQSPYAYQGQHGAQPSMYSAVGQSTPQMPTQAAPQQYPGYAAAGYGHQPAASQSVPAHLAHQQGGSQYSTSPAPAQAAYAQQAPVQQAAGHYQYPGGVQGQYAGGQETSASAYMHEYLQQQAPAHANGVAHGHQPSMSQGQHYQQWNRATSPAPAPAPAPAPVQQASAPAQVPAAGGAQPQGHAPTGQYSDAGQPILFYVKALYDYQATNPDEFSFTTGDIIAVTHTEADGWWQGELLDEARRKAGANTFPSNFVALLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRW7</accession>
    <name>W3VRW7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRW7"/>
    <dbReference type="HOGENOM" id="CLU_1267612_0_0_1"/>
    <dbReference type="OrthoDB" id="2545620at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833335" evidence="2">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="224" mass="25890" checksum="88720CA44BC0AE65" modified="2014-03-19" version="1">MMLLMVTLIALTLDAATRIVYESDPIRLEVPERLAMNMHHLAYLEGNPEQPYGIHLQLQSQAFYRMMIQHYYEYKLGPVNRALKEGKRQILLLPIIQGRLPDHLYDIEAAFRTYDQLVSDFWERHALLFFEGLYKRKPVNPNEANHFRDLRSTFSQLPSDRKSVFANTIRRKDETYDHHFSAVALSFKPSALDQMQRVQNGDTDFERKISNPLASSSGSGASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS69</accession>
    <name>W3VS69_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS69"/>
    <dbReference type="HOGENOM" id="CLU_026337_2_0_1"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="290"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="585" mass="62568" checksum="CA384D700EF00AEE" modified="2014-03-19" version="1">MASFADELLADFGSDEEQEIQAQPSDDAQATTHQNGTKRTHPEDDGDGKGAQDSSSKRVHIDDADLDDLEDGSDDEDDPMNKGEGSSSNGSATTGGVTLGRNAVQPAAERDQAEVDELDLSKTTSIRSVASLLRSGSKVYGVLKQIDHFMSLPEPDLAGVLEDSPEYHLIVTANNIAVDVDNEVMLVHKFIRDHYSPRFPELETLIPAPHDYIQAVQAIGNDDEISSAKLEGVLPHGTVVVISMTASTTSGRPLPSEEWKAVQEALEMVLELESVRSRILAYVESRMSFVAPNLSAVVGTRTATKLLGAAGGLEGLSKIPACNLHLLGAAKKNSIGLSTAHGGSLRSSGFITQSELVATTPDDYKRQAVRMVSAKALLAARMDAGKTTSRDGSYGRKLHAELVRKIEKLLEPPPQKLDKVLPVPKEGGGKKRRGGAKVRRAKERNGMTELRKMQNRMEFGKQEEEAFGYDESVGLGMINSSASGKVRAQTAEDRSKARMSKANKSRIAALRGAAGGTQSVLGRGGADGTASSLAFTPVQGIELVDPSRRKAQENEKWFKQGQFSLLPGAKSSLPGSMPPPPKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSC7</accession>
    <name>W3VSC7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSC7"/>
    <dbReference type="HOGENOM" id="CLU_2688846_0_0_1"/>
    <dbReference type="OrthoDB" id="10369785at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833348" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="74" mass="8236" checksum="C441AF467423F925" modified="2014-03-19" version="1">MVQIARSSRTVLLLVALFALASLLAQPASAAPVPGNPYERLQPHKTMGQFLSKPLKTSPWSKIKKLFNIFPKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSH8</accession>
    <name>W3VSH8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable RNA-binding protein 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">RNA-binding motif protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSH8"/>
    <dbReference type="HOGENOM" id="CLU_066926_0_1_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12355">
        <property type="entry name" value="RRM_RBM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039157">
        <property type="entry name" value="RBM18_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF304">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="53"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="228" mass="24241" checksum="7F3ED78F68BB3520" modified="2014-03-19" version="1">MAESERATTSNDSPNPYLTRPSTSTTGATTASSSSSSSSSATTSKGAEAKHETRLYVGNLHTTVDEYTLIQTFAKYGKIAKLDFLFHKSGPQRGQPRGYAFVEYAHADEALRALAATHGKTLRGRRIAVSFASKTADADQHAAAAGVGAHRRDRRAGHDGQAARTTQLSLSKNAKQPHSTDAKIAAMEAKLAHLRKAKSTEPSGPPATGKASLPPKPAFTARKHQHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSQ4</accession>
    <name>W3VSQ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSQ4"/>
    <dbReference type="HOGENOM" id="CLU_003442_0_1_1"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10812">
        <property type="entry name" value="GH38N_AMII_ScAms1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000010">
        <property type="entry name" value="Cytosolic alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="8">
        <location>
            <begin position="676"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1259" mass="142591" checksum="D03616718B6BBD2B" modified="2014-03-19" version="1">MTYKPHRRIPDKDRVLAGYKAALNNPATTSEARSYARKQLLKVNVLTATLHRRGSAAPHQRRTLPHRPRKSTKCAGGTPLPPSSHSTTSPTHNRSSAAPVEPWTSKDGTMCQHDAPRGSSKTHDYPTHASEESRPVRSGLIRSVHERRLDEFVGGQFGDYNLASVLFEARTDEEKYVSIQSWTPKPGSKPSFDEAKRQSYVKAKKGIKFGPSWTNHWLKLKLNVPKDWVHKEWLQLEFDPGCEAMIFTEAGMPLQGITGGFEDNRRVDFPLKQEYRNGVTFYIEITANGMFGLPSDGSGDPDPNRYFELQSCDIVVKRAEAWKLLWDFDLLKGCVKNLSKDTELQNRALWVANQIQNTFRKADLDSIPRCRKLAQEILGKDWEDHVDSIYDQDVVKGREDVRIWSLGHTHIDSAWLWPYSATQQKVARSWSTQIDLMDRFPEHRFTASTAQQYQWLETLYPDLFKKVKGYVEDGRFQPIGGSWVECDANMPSGEAFARQFLYGQRYFQSRFGKRCDIFWLPDTFGYNAQIPQLARQSGCDYFFTQKLSWNNINRFPHNTVMWVGLDGTQIIVHMTPVNNYDSKCSVEEIVRGVKNNQDLWVQPHALMLYGFGDGGGGPTEVMLERLRRARAANNNGFKDMPRVHVGRSAKDFFEHVRESTDNGRRLATWSGEIYLEFHRGVYTSHGSIKQWNRRFEAFMQKLEWIATLASIKATDYKYPKEEIDAIWEPLLLNQFHDCLPGSAIRKVYDDLEEMYADMTVKGKKLWRKALTALGVGEEAVGASAKGYTAINTLDVPRRELIEVRLSDNMARAEAIALSHQSMQLCNAGQSALLLLEDATGRGQALVQDKQSTVLAQGQAVRAEQLEHNSFLLQSAAIAVKVSKGRITSIYDRLADRELIETGRTAGLAIAEDYPPQFDNWETELYSLDTTEGIPFTNVRIAEAGPWRASLALEAKFGQSTVRMSIVLDALPATPLLGEKEARPLLRFDTQIDWWEKHRFLRFEVPTRLRSDSASFETQFGITKRPTTRNTSWEAAKFEVCGHRFADLSEEDYGLSILTESKYGYSVEGGLMRLSLLKAGTYPDAHEDEGLHQFAFALYPHVGGVGKGKVVQVARVFNARFDVDYGRQSNVDIATLERSTGTASSDLQMPIELVDGTQAGVVIDTIKRAEDDFEYYGQKPKDSKSFGIVVRLYESLGAHAKPTIKISVPVKATALTNLLEDVDDKSSEELAFNTYADEKDHTYVQLDFRPFEIKTLKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSS1</accession>
    <name>W3VSS1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSS1"/>
    <dbReference type="HOGENOM" id="CLU_075596_1_0_1"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="210" mass="24459" checksum="78B250DD3183CB18" modified="2014-03-19" version="1">MSGRRAPPAPRPYADAPRSYRDEPSSSRRRRSPSPPRSRHDERDWRRDDRDDRDWRRDDRDDYRVRNRDADRYRHDDRPRVRDRDDPRHEPPRPRPAAYNDERDRKVRDPPSTSRRSYSPPPQPPHLPETSEPREKESNGEGKGEDEGDVDADADADAMAAMMGFGGFGTTKGKKVDGNAAGAAQVKKERTWRQYMNRKGGFNRPLDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSX4</accession>
    <name>W3VSX4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">PaG_00590</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002661_2_1_1"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023415028" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023415029" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="543"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="716"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="173"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="349"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="418"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="798"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="895"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1129"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1189"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="1276"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="1276"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="1275"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS64649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1317" mass="142669" checksum="DDDEFAD6C0FD2461" modified="2014-03-19" version="1">MSSQQPPTASSSAPPLCTLRVQVLSARNLAAKDRNGKSDPFVLVSLPGSVASAHHDADSRSQTTVKPKTLDPTWTADEATFNFPVLPEWFGPNFAAVATEDIDSSVVRRAIQHAIVPDPAAQAPTSSGAQTPDTNAKSRPRLNLRSASSKRIQGAASKILVAPVRLGAAGARVVGRQMPRPMRLRRRNPLTNSRPSSTLGSDSPSTAALQDTKPPRGSIQLDASNGMVSSLEFVIWDKDRFSGNDYMGECSLQVAQWCQDGLAEWSNAQPLWLPVESSRPDAKISGELQVKVGFVPLDAAAHSSSGPRSWSVQEVYNRLVLATLGSAGAAVRAIPASQSVGTAAAQEAFVDDGLSSDDSDEEDDDDDDDDEDDDDITDRDDDLITSDGDDRSDLNDGIEFDSDDEAVYDQHYQSIAATPSAASKSSAAPQSAALLTPPPPTQPTSRPGKYRRMFSRTKGLRSAQTSGAATPIESTSSDVEAARSTATGTDLGASTDAKPRTRRRLPGVKRLKSSNAVPAAADGSTPRTRTRRIKRRGGAAGRKRGEYAFKAEMGMDIIGIVMMEVQGASDLPRWTNVTHTSFDMDPFAIISFGQKIFRTRVARHTLNPTWNEKLLFHVRRHETNFQAKFMIYDWDRMSSNDYVGGASISIAELLDAAPKPDTLTGLYADDDGVLGSMKQFVLPLSRVEKDEEVKFKRTTKPPSLTIQAKFTPYDALRQRFWRQLAQQFDTNDSGTLSRLELSSMLESLGSTLSTKTLDSFFHALDKNPDEDELSFDDIIVALEAEVQKPWALKRKAMQPSNLNSGAQTPSLLGGVGDIGTDVNQDADLSGANAPSADGPGTEAAAANQAGGNMRPLDRDFSALSMTSSTDSSSTGGGAQLADPGAGGAADKRRSASNSSSGMLSTSPTPPLIQVEGEGEAGEAGSSYDDAQAVERVVRLQSCPLCHMPRLSNKGEMDIITHLAVCAAHDWRRVESLTVRNYVTASQAHRKWYTKVVNKISQGNYSLGANSANIIVQDRISGELMEEKMQVYVRLGIRLLYQGARSRMEGARVKRMLKNMSVKQGVKFDNPASAREIAGFIAFHNLDLDEIREPLESFTTFNEFFYRKLKPDARPNEEPDNPARLVSGADCRMMAFESVSEATRIWIKGRDFSVARLLGEAAAPSELDSYQTGGALAIFRLAPQDYHRFHCPADATVGKPTWITGQYYTVNPMAIRSAIDVYGENIRVVVPFHSDHFGTFYAVCIGAMMVGSTVLTVKEGQRVARGDEFGFFKFGGSTIVLVFEKGRLAWDQDLLDNSRAAIETLVRVGMGIGRAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSZ5</accession>
    <name>W3VSZ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSZ5"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="24"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="380" mass="40920" checksum="F2BC6815CBBBC810" modified="2014-03-19" version="1">MTGSNNIGSDVPKVMRALRIEEFNADPPYVLRDDVPVPEVGPNDVLIRIATAGYCHTEMMVARGEFASKSRNPLPLIPSHEPTGVVVGLGTDAASNPAGGNGSGGPLKLGDRVGCITFRDYCGKCAECKRGTPKYCADQDMVGVTADGAFAEYMRADYRSCVVLPDQLDFDSAAPLFCAGATIYTAIANCNLERGQTLAIVGAGALGHLGVQFAKCLGYNVWLFDARDAPLEMCKSLPYPPDKTVNSGNVDGHDDKAVNELVHTQLGGQRADATIMATDVIPAYEFGLAVTKNHGLFMVVGQPNEPIPIHYNHFIFRDITVKGSLLGDPKTTHEMCELVAKHKIQVKTIAYPLEDVEKMRADYAKPGHQGKMVLRVNPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTR3</accession>
    <name>W3VTR3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTR3"/>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="524"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS65023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="699" mass="78589" checksum="F6D9A5EF34CEDDFB" modified="2014-03-19" version="1">MGLLSLGTPMEWKDAQPLASHVRKHGIQQFLSLWNKIKDRRGDILLWGDEIEYIVVSFDEETKNAKLSLRQEEILKVLSASDKETRASVPGLAGQIPTFHPEYGRFMLESTPGSPYGASPKELRGVERNMRLRRQIARSHLKPNELPITLTSYPRLGVTDAPFTEPHYPANGNASRSLFLPDELINPHARFPTLTANIRKRRGSKVAINMPIFKDVNTPSPFIDPSIPWDRDLFPEDAEAKAGAAKPDHIYMDAMGFGMGCCCLQVTFQACSVQEARTVYDQLIPVGPLLLALTAASPAYRGYLADVDCRWDVISAAVDDRTPQERGEEPLPLPGHTPRGGLDRDADKIPKSRYDSVDSYISQDPLNRRCYNDNPLPINDEVKEQLRQAGVDDLLSDHLAHLFIRDPLVIFSEMVDQDDETSTDHFENLQSTNWQTMRFKPPPPGGRIGWRVEFRSMEVQITDFENAAFSVFIVLLTRAILSFGLNFYMPLTKVDQNMARAHKRDAVNTETFWFRKEVYRTRNRHASRQASRQVSRASSAENLQNSVNGNGNGGAGGRSSPNSLASSDSEAVEEEYAEFTMDELMNGKGDDFPGLVGLVHNYLDSLNIDVETRCEMGLYLDLVSQRASGKLMTTATWIRQYVRNHPAYKGDSVVSQEINYDMIKQLDLIERGEVDAPSFLPKGYAQRRKSHEAQPSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU20</accession>
    <name>W3VU20_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU20"/>
    <dbReference type="HOGENOM" id="CLU_041217_0_1_1"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS65054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="281" mass="31197" checksum="013D6B05CE0E9F91" modified="2014-03-19" version="1">MLRNGGAETDQGVIFAGAKTSFRNSSSIAFLPRQRCLCRSNDLNASQQTVRKGGGALDIDALPTSRNPRRSRLAGLHNQDAGSGGNSDKSSVILKVGMVGDSQIGKTSLMVRYVEGSFNEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQARGFNKTAIPFLVGTKYDHYATLPREEQDEITKQARRFSKAMKAPLIFCSTSHAINVQKIFKVLLAKAFDLKCTIPEIKGPGEPLLIYLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU31</accession>
    <name>W3VU31_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU31"/>
    <dbReference type="HOGENOM" id="CLU_065417_0_0_1"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30985" checksum="D9F72BAF3341993F" modified="2014-03-19" version="1">MPRPSASTPHLIWAAGHFLCFFAGLRYLAGTLMFATQSGGLSRWYTATYLGAILSYCVVVYKSFGVPQLNKPYIQRALMDENVQYLFLAVYWFMSKPIFITILPFVTFSLFHVLTFVRTTILPAVFPTPTPPAQGAAQGATQQQSKLAKMVQGWVKANYDPAMRFVAYAEVAIFARVLFGALLWRNSLMAPLFYAHFLRLRFYMSSFTRAAFQHVGAVLDGYTQHQSCPPGVRKVYLTLTDLVARYASSVLSVQNNQAQQNQQPQQAAPQQPAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU92</accession>
    <name>W3VU92_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU92"/>
    <dbReference type="HOGENOM" id="CLU_037990_1_2_1"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24899" checksum="F626A4A612CD2E6B" modified="2014-03-19" version="1">MSTATPNYSAGNDRFGAEAATWDSQPEVVESSRLCLDAVLRHSDRFPSLSSSSVLEIGCGTGLLTVPLAQHVGSILALDTAQGMIDMLSAKLSSNALQHKVTAKVKLLESADDPVLEAKKFDVALSHLVFHHVPNMQQLVDVMFGTLNNGGRIWISDFEDDGPQAEAFHPKAKHAGVERHGLKRDEMHNILTNAGFTNVEVFESFQMQKKVESGETQSFPFLAITGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUH2</accession>
    <name>W3VUH2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Damage-control phosphatase ARMT1-like metal-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUH2"/>
    <dbReference type="HOGENOM" id="CLU_030117_2_0_1"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="10">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="10">
        <location>
            <begin position="498"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="318"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS65194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="610" mass="67998" checksum="794947232C0E331F" modified="2014-03-19" version="1">MVWSPPVSLASAKDKTSFAYESTVHRWPAILTQVIDSIYSANYALSYSRTNQSAKIDEGKQIIEKIAALKHDMSRDRPLEPIGVVSGKDAGEGPSTELFDSVIDKEHWTWFQAPWLFAECYLYRLLRTFFARSQHWKQYDPFSKTKLDTFKSSGNAISALAVTIEELVAKSLSSEQGPESTPQGREILFHEMAQMSLWGNATDLSLLTNLSYADLQALQTTGREQQEARSKYILANDLDKAWTRISSLNNGRVDIVLDNAGFELVTDMIFADWLLTTPHVGEVVFHPKNMPWFVSDVTPPDFRHTIESLLEPSFFARQEAGQDRHRSVSRSRDLQADPSKYSYNASGGQGAQPAGSRSLQMADGNERGRSPHPSGSLHLQAREGSVDSTGRGRTPAGSRNFQMDAAYFKNARSQTISPSRSYVMDSSRFSSLSIHDEEPSGDDERHGRGRSTTVKDETPSSQTPVQAMVRRWMKHMESGRFKLSVPLDTPLGADTGAANGFWTQPVSYANMATHAPELHKELATQSDLVIFKGDLNYRKLTSDANWKSDTSFREALGPLAGTVEILALRTNKADVCVGLKPGQEAEVEKEDAKWRVDGKWAVVQYCPRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUY8</accession>
    <name>W3VUY8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUY8"/>
    <dbReference type="HOGENOM" id="CLU_071097_1_1_1"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="222" mass="24661" checksum="1A4F98F5912D300C" modified="2014-03-19" version="1">MSGWMNLFGKKDNKNSARDAIVGLRQQLLMLEKKEEHLNKKIDDELKKAKANVTTNKRAAQAALRQKKAYENELDRIAGTRMTLETQVNAIESANMNLETMTAMRKGADALKTIHGSLNIDKVDSTMDSIREQMDLTNEISDAISNPVGMGNDIDEDELKNELEELEQDELNERLVGADSVPLHTPAVSAGPSRAKEAERKQAVVEDDDDAELRALQAELAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVQ6</accession>
    <name>W3VVQ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVQ6"/>
    <dbReference type="HOGENOM" id="CLU_012494_3_3_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="79"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="432" mass="47737" checksum="6495F5FAF7A74DA1" modified="2014-03-19" version="1">MTSLYNKIRSVSFDVLWRTALVRLPRAVPLSALKWTSPEGPHPFIFQMPSRSADYTIPLYIFIPTRFYNDWPSTGAPVLVDFHGGGFYLGSCLEQAPFCSSMARQLDSIVISVDYRMGPFHRFPAAIEDGEDVLSAILDRDFAGYEPLRNAIAARVHSEKAKLAKSGAEALAEQHKAELQQGKIEQVSAPPTSNPSSAGAASSSSFDFDASKVSVSGFSSGGNLALNLALHIKPPELDMEWPSKFAQDHPAPIPLLLFYPSFDLRQLPSQRSRPQHMALPSPFWTKVADALAPTYAEQEQTHHPRVSPGLASLESLHPAARVFLVLCELDTLAEQSKEWVAKMQNHERTEHLVVEDVANMKHGWTQMPDGWLSPEEKQAKEAVFAKAIAFVQWAWNGSDGDTKPRSEVIVPQKDTEQVSKTTVSTASMAEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVV3</accession>
    <name>W3VVV3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPP transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVV3"/>
    <dbReference type="HOGENOM" id="CLU_444093_0_0_1"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="250"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="616" mass="66200" checksum="7898165DF2DBDA2C" modified="2014-03-19" version="1">MRLEEGSADEVSSHAPTTIPEEATPVSPLSQGFPTEVPPTTTAQQQQERAHEGRFIEIISSDGSRASAEDGATAAPPAATTQVPETEMKAVRSTKRVLRSNSARGQAKIQTTVPPQAQQGSPSTDSTAHKASSHLYTPSSEGAKPKPPKSGSDEDADDDHDDESHPWLAALYPLSHFIGYRPLSHPHTPAERRRTPSDPGFRRFHYICGRVLSFGLEPSGETGQIARYRDPDTGEIQLVQMYREQVGAKVVNSIHSLIAAWVVIALLSLVSRSPFHRAHNAPLVIGAFATEAVVTFFAYRTPLAQPKNILLGNTISAVIGVALQKAFQGTSYSVTGVYGVDWAAAATSVSVAVFAMQILGFTHPPGAAIALLAMTNPETHRLDWWLVPIVVIGSLIVIGWALIINNVGGRRYPENWIYMHAFAEPPIIGPEKLPFSNSPYELPPGRRKRKRPEGEKGFYRVAQGAKLDTGFSAPKRATAEEACNEATTATQAFSFGTGAIVKPLEAAQDGRMTRASQVTKVNSGESNGAALETSTTAQSVAPTAPVAPPSTMANAKTAEGGQVKSRMIETEAMVSRTNSKSSKRSRRSVVVHVNENRRHSTGSQKIPPVPAVQWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVZ5</accession>
    <name>W3VVZ5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVZ5"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_43_1"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000639">
        <property type="entry name" value="Related to serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="282"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS65012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="488" mass="54355" checksum="3787AA03E8E5B756" modified="2014-03-19" version="1">MGAVCCKPEVIDFDGPVDLYHFYLLRAVGKGAFGKVRVVQHKQTKDLYALKYINKAKCIKMRAVSNIIQERRLLEEIDSPFVCNLRYAFQDDENMFMVLDLMLGGDLRFHLDRTGNMSEDVVRFYVAELALGLDYLHRLQIVHRDLKPDNVLLDEKGHAHLTDFNIAVHFSPRRPLTSIAGSMAYMAPEVLTKRGYLSSVDWWSLGVVAYELLFGRRPFRGKTNSALTHSILNDRCTFPDNVENLVSRETVSCIKSLLERDPRKRLGCRSGIDEFKTHAWFAGMDWPAMEAKQVPPPFEPDSKKANFDATHELEELLLEDNPLKAKKRNGNADFDALPPEMRQMEEHFLPFDHLKQRRKSYFRGTRASGATAAAAASNGQAPPQAQQGPAGEHELSQISSVAHTLQDQPLSETAPAPATPAGEAQRLTPVPHEGRARSASPSGSFGVERYSEKNDQLAVPAATYGRAGGSGNAPPQPEIDEKAASGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWB7</accession>
    <name>W3VWB7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWB7"/>
    <dbReference type="HOGENOM" id="CLU_1705000_0_0_1"/>
    <dbReference type="OrthoDB" id="2557317at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS65127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="154" mass="17366" checksum="B0CE069798D8CB33" modified="2014-03-19" version="1">MEFTQPAEASTIFTYWESNNIVRTQNVYHFKIESDHHGKAGRQQGGDWFQLPPLYCSGVSGSSTYVQSRIMSQQSGRQKEYSDEGGVIIFNIGIPACQQSSVDDGRKVIDQFIDLLRGYADDPNVTIESAHYEPATATIFINDPTERIEPIERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWC7</accession>
    <name>W3VWC7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWC7"/>
    <dbReference type="HOGENOM" id="CLU_778730_0_0_1"/>
    <dbReference type="OrthoDB" id="2553688at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="356" mass="40713" checksum="114C781679B57CE0" modified="2014-03-19" version="1">MKPVALRAQSAHLHLGHVPLHLDRPTWLGKVWCCFFHQRPRRRSVQRYAAQFVSLLVFTPTPPPRVAVTMHIFQVLSALLLATSFAVAGSPRLTPLVQPPAGREDLYRSAELLPTDFPPDARSGFDTRFRTSHAYSVLGPEGFWTESYLRAHYIEDVPRRYPLHLYPHPPPFDVWLKEQRLIRAINMLAQSTEVEIARDGTTKAELLDLEMLQVYLKGLLRQTQIATALRYANLPEEWRLFEESLYRYWASFVHVSQGRAVQVFRNGHLDQHLDHVRKLAFGPGLEEPLASDGAKAKPPTRENTRSKVRTPVQQEAASTSRSWRGARRVADATNSAEERESLVKQLHKAFVGRLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWF3</accession>
    <name>W3VWF3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgi to ER traffic protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWF3"/>
    <dbReference type="HOGENOM" id="CLU_062890_0_0_1"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="39934" checksum="397BBFCC840B7515" modified="2014-03-19" version="1">MSDTPPAAADPTATASDAVDAAEAARLKREARKARILSKGSDRLARITNTGRGEGASAYLNDTTPSLPSTPKPNDTPAASAAAAASVARADDDDPLEVDISTLPRRGGPFGAPFGEDATNPFLMGGSGAGAGEAQNPMEALMAMMQGGPPGAGGPGGAPGQQPDMSGLPPQLAAMMQQFGAAGGGGGPFGGAPGAAMPTAVKTKSLTERLFGVVQATLIVALAILAAKTSLFDTDHSSVVPDSVTDTFTRDAPAVGVLQRWARLGYQRPSADEWGLNHTSTLSSLPMGPLSSLPLFWIFLGLEIVLQAVRIAVVARKTPAPPSMLASLTAMLPIPNLHLAISLVGKYLALINAFVNDIAILVFVFGATVLWSAHQLGGAGMLESPYVHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWL6</accession>
    <name>W3VWL6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWL6"/>
    <dbReference type="HOGENOM" id="CLU_008515_0_0_1"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="722"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS65161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="798" mass="84858" checksum="812945C91BF9C05C" modified="2014-03-19" version="1">MSTAQESIPPTRRGGATSSGRRGGGSSSNSSRGGRRANFGGSLTAADANAAPANGNGNSNSSSNRSRPNNSRQPRTKANQAAQGSNSAAPTAAPQPAAASADNTITTTTTTDDDDDEGELPPDVDVCFICADPVKLTSLAPCDHRTCHICALRLLVLYKKDQCTFCKAKIDRLIFTSSPTKNFEDFQPTDIPYSDRKLPISFESKEALEETVLLLRYNCPDPNCEVACTGWRDFKAHVRREHDRLVCQLCITNKKIFAHEHTLHTAQSLAAHEKQEHKLCEYDRTLFYGDDELFAHMRDRHEQCHICKASGTAEERWKYYRDYNMLERHFRNDHWLCENAECLEKKFIVFESEVDFKAHQVQEHGNELSSRERREALRIEANFSYDDSSSEARQGGAGRSGAGRKGKGRAEGTDAGASASENRDVLGVSSLASRAHVPGAGPANHASRRAMFGSGLTTPAPQGVAADRVRTVTDERSIEERHQAYMDKASRVLGGSEARIASFRACVRAFKSGESSARDLISTLHSLVQEMDDCAPLVNGLVDLLDDRDKSKALSDAWAGYRIERTQFPSLTPSGGVGAGVALGSGYAGAGRALKNIKKSSAATSAVWDNVERAASASSGHGAGRPVALREHFPSLGSGSARSTSVPGSLAHAVAHSAATRAAAPSAKWSAASPVVVAPAAKPYVARVHSGGPTRAAVSASAFPSLPTNAAKKAINEQKKSLFNRSPGASGGATPRGSGSGSNTPWIPQPGRIDDGQGLGSLDGLSEALVESQEGAGKKKKGKAKGVQLAAFGGVHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VCX1</accession>
    <name>W3VCX1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenylate kinase 3</fullName>
            <shortName evidence="7">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ADK2</name>
        <name evidence="10" type="ORF">PaG_06407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VCX1"/>
    <dbReference type="HOGENOM" id="CLU_032354_1_1_1"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="51"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="287" mass="31659" checksum="3947D754ECD4F2F3" modified="2014-03-19" version="1">MTVKVAFRPLANAGCTARLGQSSRIGAIRGFASTRRVSDDQMRMLIVGSPGSGKGTQSTRLLKHYDFSVLSAGDVLRSHIQRKTDIGQRADAVIKQGGLMPDQVMMDLIGAEVKTLGAADWLLDGFPRTLGQAQMLDEMLDAQKKPLRLVVNLDVPEDVILDRILQRWTHLPSGRVYNLSYNPPKVEGKDDVTGEPLSKREDDNVETFGKRLKSFHAQTEPMLEHYRQKSGSVIDIDCRTQTSPDASTTSSQDLFVNLRGDTSNQIWPHLVAIVQSRFPALKSASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD35</accession>
    <name>W3VD35_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD35"/>
    <dbReference type="HOGENOM" id="CLU_2074169_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="118" mass="12618" checksum="160920CE811D58A4" modified="2014-03-19" version="1">MDGLNLAEDLPLSARQAGSPSSGSTKPTRPKMRRRHQGLDAHRNPAEDAPFPASSPSCLPAWTAAFYAPPRIGEASQARRLTVAVPHAACRSIKSHSSLFRSTPALAAPTRSMRYTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD70</accession>
    <name>W3VD70_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD70"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="280" mass="29273" checksum="49F565ACDDFE9A17" modified="2014-03-19" version="1">MSTSEVACEKTPSTSSLGLFNLAGKTALLTGGTRGIGQACAVALAEAGASVILAVRPGTAAGSDGNHPALAAITAVANQASSQKHSTVDADLSDLEQVKTLFERALAQSPSGAIDIVVNCGGIQRRHPSTDFPEADWDEVLNVNLKAVWLLSQAAGRHMVPRRQGKIINFGSLLTFQGGLTVPAYASAKGAVGQLTKALSNEWSKHNVQVNGIAPGYIATDMNEKLLADPTRLRQISERIPAGRWGDPADFKGPLLFLASQASQYVSGEMLVVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDF7</accession>
    <name>W3VDF7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PaG_06605</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_6_0_1"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000391">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="21">
        <location>
            <begin position="623"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="446"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="833"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="900"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1169"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1664"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="446"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="975"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1171"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETS59673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1750" mass="189290" checksum="50D0EA4F61308A13" modified="2014-03-19" version="1">MGSTVDSALSGCGRWKRAGKEVRERGCRWAFLRASASLFKNLKNGHAGTICHERGMPHRQQQKLENRRFQKSPVPWQREGSGVKGSHTGALTLADCGSGGWDGGGRVPQKRPTARSTVLAVRELNTTALILCTSVACLGTAFASSLAGNHLQPPASQDVILASTASVLIASASASIAAKVPEGPLRAIIMSFEATQGPVPTSGDEPRSASMPTSQGAADEAHTSTSDNASEVPQQSVDLSDSFGTPPFPKSPRLDPSSPRNFSTISSLAGSRELGRPVLEPTTRIFAVGPTASTPPAKVSLPPMRPPGISQGQPADVAFHAEPQGLMQMLSLVGSTLLEAERVGFAEDDADELEAQPSARTADPSDPFGIPHDVTGSASRRSTRHFAPGLARSVFDLASAGTAKGRLRALAREDASDDGSTPQGSRSPLDGSVHTIGASRKKRISLTQSEIFASPSDPTADSSGRRASSLRSQLQPSPFASGSTSTLNCELDSDAPDSLDQRSAGQTAAGTLPIEKRSISMQHQLSFSPINSIAQLPTEGDVDPLLIRPYSHSLVADTPVSDSALDHDRLEQQLRDTFQLDASETLVMAQPCWLFRSLLLQGHLYLTNGHLCFYAYLPSRDEKVVKTGVLGKRTRRTHRFSKHWASLQGSKLSWFDSDRDPYFPQGHIDLRKVSAIEPSQNHKDRFKLNTPARKFTFLAEDEASRDAWVSALQKETFRAQNQGESVRISIPLETIMNHETTLSVDGTEMVCISVVDEAGDFSVDEYYFLHLGKPSAFIAALNGLIDSGLGSVSSLQSGDAALNLSKLSIRDSTGAAYAIAMSRRSLEEVPTLPKVPVKAQAPDTTAPADRTETLVTSNAPTMAAVAIPQSGRRKSQDGSADGVFSTTPRAAALNRLSMESTHTYPPSPSLSDPPTSFDQVQREAERSWSIPGWLKSAPAKVLGRTHSSHPHASNAQDSERTSGSKRRRKVLETWSGDNTESISREGSSTDTEDDMLSHSIHSTQSGFSMLDADDEGQEDLGRVAAEFRDTFGVVQDEGLVGHTHAYLYRVLPVAGRFFVSERHLAFRSSGIAAKTVGRTLMLVPLQDVISAAKQLAFRPGHHGMVINISGHEELFIEISSANRRDELLSLIEYQLELISAGHRSKESRDTVNREQSHALVLRDLSEKITDDPSTTSVASSADSSMLSQQSSDLDTSGDLSHLGGRASLLTFAPTAPLTFTMLTIGSRGDPYIALAKGLQADGHNVRIATHAEFGDWIMGHGIGFSEIGGDPAELMRICVENGTFTVSFLREGVTRFRDWLDDLLASAWRACQGSDVIIECPSAIAGIHVAEALQVPYFRAFTMPWTRTRAYPHAFAVPNNKAGGNYNYMSYVIFDQMFWRASSFQINRWRKALLGLKPTNFDRLEQHKVPFIYNFSPSLVPRPLDWYEWIHVTGFWFLDNPDNSSSKKWEPPEELVTFIRRSRERKRKLVYIGWGSIVVPDAEAMTRCVLQAVRKSGVCAILSKGWSDRLSGDASKRSAALDPAVAEDVFQVSSVPHDWLFPQIDAACHHGGAGTLGASLRAGLPTVVKPYFGDQFFWGQQIESLGVGSCFFWGQQIESLGVGSCVRQLTADNLAAALITATTNAKQIERARKLGEQIRAEDGIGNAVKAIYRDLDYARSRVKRDTRIESDAPAAPRAENTQPTELRAGQLGARPELARTASQGFDDSHSSDGWSDIGGAPLSPSPPNADADAILDLSRAGPACVEAPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDG6</accession>
    <name>W3VDG6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDG6"/>
    <dbReference type="HOGENOM" id="CLU_010348_3_3_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="350"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="469"/>
            <end position="471"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="685" mass="77444" checksum="95B568F318C99791" modified="2014-03-19" version="1">MSKSARVLYWFRTDLRLHDSPALQAALDLKPAALFPVWCWDPNYVYKHRVGVNRFRFLLESMNALSERITATQSNSQLLVVRGEPTELLPELWKRWDITHLVIEKDPSAYGRRRDTLIREAAKKSKVEVVAVQGHHLFDPEEVVKRNKGKPTMAMSTLQKIVSDMGDVPKPLDAPKDLPLPQLKDSKSKTLKDLLADLADSLDGLPHYTGKGREGPASMDLNSTELGGQRDKEVTCYNTVNGEAAELFAVPTLESIGMDASKGKATIKGGEPLALEKLAKICKDAEYVATFAKPKTSPGQSAEDPSTTLLSPYLKFGCLSVRKLWWDAEEAKKKYKGGSKTGPPENLNGQLLFRDMYACAEHAIGDDFQRVRGNEVCRYMDWYLPTHYDKNGEVILPRPPGDAVSEARLSAFKLGQTGFPWIDALMRQLRLEGWMHHLGRHSVAAFLTRGQCWISWERGAEIFDEYLIDWDPCSNPGNWMWLSCSAFFTQYFRLYGLATFPAKYDKTGALVRKYCPELAKFPDKYIYEPFNAPKDVQQKAGCIIGKDYPFPMLDEKETKGENMQRMKICYQANLHGTSKEVLDGKADDMLRKKHGFKEPKEFDWNNRPGAKIPDWAKPPKGEENTTKGAPDTNGAAKKEDEEDDEDGSDSDDIVYKQEDEQKEERPRKRKGAAEEKNGKGKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDZ4</accession>
    <name>W3VDZ4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDZ4"/>
    <dbReference type="HOGENOM" id="CLU_345183_0_0_1"/>
    <dbReference type="OrthoDB" id="2126185at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="774" mass="87007" checksum="03B7B9ABF8385447" modified="2014-03-19" version="1">MSAAKPSSMPSFGDRHLAPTMSPHDPSLRSLMGSLFEPNFLILVTYLAINLYLAFRVIRLATRRHGELRTTPPESGELGLLNEHGDMSFERCMQAHDTLFHPEQHRRHRRSDTPAADMLIRIATWAFKSDAARAKLLFCLLALLSLGSTWYYMIAFLRHSYASYLERCHLTGYLLPPEPPAFRLDAPHLLAPAVHLRLLRISQWLGSLSLFKEAWMEVIRDAPAWWWSSEICIVTVGAWALFLRHESKRLRMPHVWIVMALGQLVAISFALNLFQLAVVYRLDTRDLLAARADKVHKPKHRVIEPLDQSPSPSPEPSPEDDPDAGPFRVMMVAPERQRSYFASREGLPPTPRDSPDPDMRVISTNVTVQRKPLPPVPTLMDKVGRILQRCIHERIGLPVFVLAGLSSVLQHPDSFTKVMIMHLFPLLISLYPAYDQFGVAEHGPRSRPRSRFGSNVGHSPSPPPTMLLTKKQALRKLLARSNPDVRALQDPKTFYLGLGLASVVLRAWLTSSCFSRTKDDGWTLQRAWRTLKLLFPTTFLRHPAQGSISSDHVCVALSVAAFVLVESGVWLWKAARASPSAAWGEPWDFEPEIDDDAMDTPNPETLRLDEADRSWIETQARVVVGLLMLSPLLGGSATLSLYLALRCDWVEQDRRKRDRDDQDMLRGSPDRDRDGLELYEETEEVRLVENTEGERYVEMRKIKIKVARPGHAAAAAREENEGAAAGGAAAGANTPPPDDGDWGAGADMTPPPEQPARRTPPVRHRHPPQRYGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEF2</accession>
    <name>W3VEF2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEF2"/>
    <dbReference type="HOGENOM" id="CLU_092849_0_0_1"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832895" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28552" checksum="0554D409D7BD5785" modified="2014-03-19" version="1">MRLWSTPSPRSPLAVFAPLLSLLALSLTAAPARAALSLRPTLALTPALFSSALIPRAVLATPVQPGIPASQRHFRIGHPAVAMSASASLPAQTADFEGFAATPLIEPTPETAQIIRDSMDLFGARPSAAIFARWSADAIFADPICHAVGAKQYMAQWYGMPAAFSLSETKAWKLTRQDAAVVEYVQLQRYKVKGLGTVKDMKSTVVIERDGKNRVTRFEDRWGHKEMNGKLGWPLRRLNAFTMPWLISVPNDAKNAPVHSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEK9</accession>
    <name>W3VEK9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEK9"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_1"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37177" checksum="239EBF1CB72168C8" modified="2014-03-19" version="1">MQGLVGAHLSPASASPPSSSAMWTAINPHPRVSDVDVARFDYAAYAWQDIKVELRPDGVAIVWLDRAEQYNTFTGPMAFSIVFAFELFDADDRVRVAVITGAGGKVFCAGAYLAQGFGAIADHAQGHRDGGGQVGLAILRCRKPSIAAINGNAIGIGVTMTLSCDFRLVADNAKVGIPFVKRGIAMEACSSYLLPRLVGVSKAMDIILTGEVRAPSDESYAALWTRAPMPQNKVLDESLKLATSLAQNSAVSMALCKAQMWRQLDSPEDAHLLESQGIWETSRLDGLEGAKSFLEKRKPDFPGTMADLDRFAFWPWWKQTEVAKYPRGPESLRAATALAAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF73</accession>
    <name>W3VF73_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF73"/>
    <dbReference type="HOGENOM" id="CLU_422177_0_0_1"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="106"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="276"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="671" mass="72235" checksum="A446EC4175278DBC" modified="2014-03-19" version="1">MPAQSQGRTLAAERSGGWANSSRPVLNFGSQRTPSYHVPDSGVKTVVWQDPALGQTAAAVEEPTLIPTFAHLPYFTAIQLETLYARQRGQRMSASTWQTNRDIATGFIQSVASRLGFPQRTTATAQQIYQRFHLFYPPSDFVLHETAVASLFVAAKLNDTHKKPRDILLASYALRYPQYVRGGSSDVPVPSSSKDALNTDELTFPTLAGQKRKHAIAATSETSVSRPLAMPIGSVAESDIDPNVLEGERKRLLSLEKLILESLCFNFHSSAHTALKMVIKLGRKSNMPKSFIRTAWKVAADMFRTSAPMQYPPNVIAAAALYAAALLARPPSRPTSTNSEEHPGDAPQADDADPMQAFLASIRAASASATPPTTDADAAVPVPLSEMAPQCDASLHVHVEDVEESVHELLDLYLACAAQLPPSLYMASAQGAGVGGSAAATPSPLSPADHVDVYNASPSSSAGLSDPAPQPANARRKLKQYEYSPPPFGLVEWLNSSRCSQLQGQVDKGLARKNASADPTLPTKEFSALLTDLKIYLRGIEYDRQRADDAFLADLGIVAQINVLPQQGAAGMEAATPSGAVGAAQSVAIELQPMTGARADALASLDKERMQVVQRIQRRKLVSALRVTFVEPGIERRPPPHSQRPPLANATTPADATSVKRRIENAKRYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFD0</accession>
    <name>W3VFD0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFD0"/>
    <dbReference type="HOGENOM" id="CLU_411147_0_0_1"/>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="722" mass="78737" checksum="7CE463C2CE9DED80" modified="2014-03-19" version="1">MHSSASLPYFSTRFAHLPHTLSSSHPPCIALYTLLHTQPPSPPHANASAKPGKVRPPATMAPKPTSTSSSAERQRDAERQPLLASSSSPSDNQDYRSIPVEPAAAPHATRPPRRSPYLTFFLRFYFAIGVLLLLPVTALLILLAINYFEPIPLLLPPHRSPALLPLWFGIISLAMLAPGLLFFELASSSTNVFHLFVLCFTVIDAILLAAVPEFRVTHSYLGFLSVALCLFSTLWAFLSSHHLQKQTIPFTLNPDFGAPIVTEVPLARAQAKWSRRFKLLNAIFGCLAIALASALVTFDLVLDAADSRFKPLGNLTLVHPTSLTKQPVYPQDPADVNPYPVSFRLHLACEEAPSQPETLKSHNTSHVVPTALVMSERGVSGVIAAQFLREMVARSASRASGREDGHLALTRVCFWDRIGYGHSDFVYQPTSVRLQTEALYHALHKSGQLDHSASSSKDKKKKNDDAELGKFMLVSTGYGHLFAQDFAVQHPHLVHSFLHIDAETPESWYTDKVGRTSGARAGYAAPNHGALGSVYYDLLPALLEPLGITRLLGMLHGKSVVDRILAPGERGRSGRKNDLAGGGWHIYGAGGSNPRLLMSSWLERLDANLGKLSPNYVQLSNTSEYESLMAKRPTAVLSSFWRIHADVQGWAQQQKSLVAAAKDGSSLVGWWRVGDRKSRSGGGDQGGAAGICDTKMGVIFCQEAVHKLIAAGQMWNSSSLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFF2</accession>
    <name>W3VFF2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFF2"/>
    <dbReference type="HOGENOM" id="CLU_937259_0_0_1"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="297" mass="32683" checksum="2E9677D026B0C00C" modified="2014-03-19" version="1">MSSYTDQEYASASTAPHNVGAVAGTTRKRIHSILGKSHFVLEPSTVAAPVFDAVPRNASFDTLRPILARLPPALHPPHSDDGDEEEDEGYGGDHSVMYTRSRLASLDQASVELWRALHSFRPLTPEYASGYAVEPPHPVSPTADASECPVFASATAGSLARLQAAFNWSNLTLRTEVERVWYGVLFLSLRKRGSESLSFYEADRQAHEEATRSGGLLMYWYGAPHPTTGANLATCIWTSRTAALAASRLPLHKAAAIYAAPSYERYDLVRYKLTKRAGDPQLHLSAWTRQDDLAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFG2</accession>
    <name>W3VFG2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFG2"/>
    <dbReference type="HOGENOM" id="CLU_398016_0_0_1"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="242"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="513"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="4">
        <location>
            <begin position="606"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="77655" checksum="99231541D5CF483F" modified="2014-03-19" version="1">MSSQTEWPQSLKDFANRAFAACNDANRKAVSDELRALIFDSFQNGTIHTTDWANASLKSLAGPSVAKKSLKKRVAPPSTPATAADPDEQARKEKRARRFEREQAQFQHEENQANLQSTSLASRFGSAHAQNGLAKQHGVDVDVADPNVIDWDEHTVVGTSTKLEKPYLRLTSAPDPKTVRPLSTLVQTLELLKKKWRTENNYGYICDQFKSMRQDLTVQRIKNEFTVKVYEIHARIALEMADLGEYNQCQSQLRGLYAHGIRGSAMEFLAYRILYLLHTKNRRDVNALMAELTEEHKEEVAVKHALDVRKALVTGNYHAFFALYADAPNMNAYVMDHFVERERINALLVMSKCYRPGVALSFIADELAFQDVAEADAFLAANNAAAYIEPTPAEIAALAPAGKKKKARPAVPLDKRQWDAKAAMQPLADAMLKFRKVDSHNDRHHKLATDRTAREHVKHLQLATTMSWFSTQWNRFAAGGSAPRSSDVIRRIEVVWGRERLQIVLPRTSEPVTLGHLRQEIASITALPYEKIKLIHRGLIMRDDRLPLTAYGLVEGSRIGLVGSREGDRPGAKTSQLSVGEQKAREKKAKEQDTSESGLMNRITEALDSAKLLFPEVEQLEAKVEREGKAEGVEDTHRRVSELLLRQLLALDSVAVNSDTTRQARKVAVKQVQQHLDRLDAAWSKFKAKPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFN0</accession>
    <name>W3VFN0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFN0"/>
    <dbReference type="HOGENOM" id="CLU_051062_1_0_1"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="293" mass="31069" checksum="0E1B11D460CBA2AC" modified="2014-03-19" version="1">MSQVDTANGHQMTAAAAPTNGTASTVSNGAHANGYTNGNGNGHSFEEKAFPHQAPQYNGGGTHAGLSRTLTPGGHYADDDLIAIANAHRKIANPLPLGVFGFSTTTLLLSLFNIQVAGIEVPNAVLGYAISYGGLAQFLAGLWEFASGNTFGATVFCSFGMFWWGYSVILIPFFGFVGTYNGQPGIYSKGSPYASEEAAAVGLYLWIWFGITTIYLIASLRGSGALFLLIFLLWVTFIMLGCFYYTGNSAFQTAGGAFGIATGFSGYYLGIASFLTPYNSFFTLPVIPFNKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFN7</accession>
    <name>W3VFN7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminopropionate ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFN7"/>
    <dbReference type="HOGENOM" id="CLU_021802_8_4_1"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="1">
        <location>
            <begin position="36"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="397" mass="42554" checksum="4AE3C4BF970C34D6" modified="2014-03-19" version="1">MIKTIQDNKHAVQVRLTKVQQRIELSNVRRFHQDVLPGYRKTDLTKLALTSQDLGQSVTRFKGSVYVKDESDRYGLPAFKVLGAAYASFVAMCEAWQLDPHTATVQELRHHAQSIAPTPLLVAATDGNHGRAVAFFSNLVGLGARIYIPSGVSLIAETAISAEGPNVDMIRLLEDYDECVRQAAAFAAAGDPTQGQQRLLIQDTAWQGYTHIPQLIVDGYQTIFREVDEELASRNGQQATHVFCPVGVGSLADAAVQHYTAVRDEATSLPAGMATSVIAVEPAGSACLSKSIAKGRLTSVQTRHTIMAGLNCGTPSYTAWPNLQAGIQAVVTIEDERALDAVQRLHTSGIAAGPCGGAPLAALQTLFSNPVEAERLGLLDDERVVVVLLMTEGGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFT3</accession>
    <name>W3VFT3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05561</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFT3"/>
    <dbReference type="HOGENOM" id="CLU_011856_3_1_1"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="93050" checksum="FB50664C78AD58F3" modified="2014-03-19" version="1">MAVNNYKHPNLKEQWGLAEDPNASDHIVTSRGQKLTRTVTAGGHDVDSSQPGFPIYHRRIANPFPLVCIATGASVLMLGFILVRNRSITNPSIYMAMALPLGMFGNFAACMFAFAEGSTYLATISGTLAGLLGGTALQFLPWTGIQATYLAGGAAGLNEYYKAEAMVYFIALIPIFLIFVASARTSGPVAGAALLITVALALLGAAYIGGAEDFMVAKASGAIFIIIGIMLFYAALSVMLAEEGWKILPSGREGIFVYNVESNVRVGASDVDSSLGYLPLSHRQGTPTPTAAPAYAGTRRHNCLASQPHPSIYSTFICASRSRNMDIEGFRKAGYAAVDRICDYYASLAERPVSAQVQPGFLSASIPTSAPETGEAWERIDNDYHSVIMPGITHWQHPNFYGYFPCNASFEGALADLYCASISNPGFNWSVSPSVTELEILMVDWVGRMLGLDDAFLSTSGTGGGIILGSASEVALTVAIAARERCIDRLTPQHPMPTVHTGTNGVGSLDADQDVASAGQSAAEVGADATLVANTRLAQWRGGLTSRLVMYGTTQTHTIAAKAALILGLDFRALPVSAESSYSLSGATLAAAIAEDVALGRVPFMLIATIGTTSSGAVDNLTEIVEVVAKHPTLWLHIDAAYAGVCLSLPELRAEMHLDAINSAAVDSFSTNLHKWGLVQFDCSPLHVRDRGDLSRALSITPTYLRTKQADAGNVLDLRNLQISLGRRFRSLKVWFVLRSYGLEGFRKHLRTTMQLANHFESLLRADDAGLLEIVALPRWALVVFRMNPKGEGVDVEQLNKAFWDDLEAQSAHFVLTQTSLPEVGFCIRFVVGSPQTQRHHVEHTWKLVAQTARSTWARFKSSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFV2</accession>
    <name>W3VFV2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFV2"/>
    <dbReference type="HOGENOM" id="CLU_527983_0_0_1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52168" checksum="8F3427CA889EC4B0" modified="2014-03-19" version="1">MATAAVDMAPRSNKPLPSPQFGSARRSAPLRSRAPVVDDADEPEVAEIDEAEPVEPFSLVPHVAEQTLHAVHSAIFGQPWADLELVVNAGTKDEVIYANSKILRKACPALMRQIRVTGRAELDTMEGELLASGVAKATTRGARPQSSRRSTNSLGLVDFGGRSSRLGELEDQHDREEEEMDEYADSVEQLQHDEHDEHDEYDNEDNSPVESVKVAGATNVGAPVEVVVPPTFSRSSSRFSKLIKFMNKDKMSPGAELEPPMLAYNAAPVTDYSNDTVGRGRVRRYSAANELTNAAPRTSTASRVQVTGCSAATLQALVFYLYTGHATFASRLPPSRRYADSATGSDGEYSDDEVAEPPIARTAKTSSFPPVFSATAAYCVGRQLGLRDLATKAFDHICLELSPQSVLSDLLSPFVDRFDEVQRAHLEYVSDHWDRVKRRPDFEHTVGRLVNGEYPRANKALLKLFAKLSVTSAAPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFZ4</accession>
    <name>W3VFZ4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFZ4"/>
    <dbReference type="HOGENOM" id="CLU_106356_0_0_1"/>
    <dbReference type="OrthoDB" id="2506317at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="188" mass="20495" checksum="CE2FF0F83D44D9E4" modified="2014-03-19" version="1">MAASTSTSHPAAGGSTRSGSNATNQLYALASRVPLIKSPSISLPKPVTLPADLHPLPHDISAYFVYPFSLESYVLDPNTPSSTTIDQLLEKHAQYLKHREEEKQKRQRDMLHRLAPGWQGASGVLQPTSTAWNQSNPSPNAVQTQQQQAQQQEPQQQERTPLDDLADHLAQLDALHSQPPATSGLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG65</accession>
    <name>W3VG65_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG65"/>
    <dbReference type="HOGENOM" id="CLU_083959_0_0_1"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="166" mass="18223" checksum="5EDFAE1A4E2F9292" modified="2014-03-19" version="1">MVGVGSRFVSEGSTSSSAAGGNEEYDPRSLFEKLQSQKEAKDAKYDEMYKLSNQFRGIDEGESDFLAHIKHEKAQEEREKRLRETQELEAFRNAQAKPPLPPPVGIADDKQKKTPEAVKDDKVPVKKKRKNVSAAVLGIKRKKSAQVAATGPVKADQPAAGDAKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG66</accession>
    <name>W3VG66_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG66"/>
    <dbReference type="HOGENOM" id="CLU_027977_4_0_1"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000064">
        <property type="entry name" value="Probable acid phosphatase Pho610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834457" description="Acid phosphatase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="50750" checksum="5C3F0DD662E914EA" modified="2014-03-19" version="1">MKATLATVSATAALVAAASVAAGPIEKRAKIAQTFSPPSASPLQQSSNYVGANNGSLPKHEVVAGKAFDRIVQIWLENTDYEAAISTPAMQALLPQGVLFDNYYAVTHPSEPNYIASVTGDFWGLSDDAFYHVPTNITTLFDLLDDGGKAGKPISYACYQENMPYDGFTGFNYTSKNYVTPGASNYTYYVRKHNPCAIMDYVSGNKTRALYNRNFNDLAVDVNASALPQWTFITPNMVNDGHDTTAAFFSNFTSYFLPTLLNNTNFNSNRTLVLLTFDENDSYTAANRIFTIALGGAVPANLKNTTDHTYMTHYSAISSVEANWNLKSLGRGDVNKTMANVFPIFADSFGYSNTDVAEADIPQTNITGVAPGPFSLTSNTAFYAPDDVKVVGAGGEPVLIKSGLNTSQTLATLPQTNLTALGQKNVWSTDPGFNNVNVSTGAAAGTSAAKTNAAAKPLVAGTGIVAGALFASFAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGG1</accession>
    <name>W3VGG1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_06209</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGG1"/>
    <dbReference type="HOGENOM" id="CLU_000288_79_0_1"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000433">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000341">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="516"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="824" mass="87380" checksum="1FD85267900FBB94" modified="2014-03-19" version="1">MGGPSSIRSLSVSDRSIEGARRGFRALFQARSDDGRLQAFGHYIPGDQAGILCCTHTHAERQLRSLISSLSPYEARTLRTRTGGRERGAAWNATWLAGVQRLAAQVNWHGEGTEQRWADWRAWLGRASWIGAANRISAVAQRRLQPLHLAPSFGLARLATVTHSLLVTSLLLSFSDQHDPSATLSSAFRLSRSVGGSRNSSSEPASVFQSRESIYLARRGLSEKICIYPLAASRKPAMTNSATAGDVERLTAQMSLSDSQLPSSNGVAPLPPQAATGGPPSRASPSLRPNQATGGPSAARPANTAVGAAERARQMAGARLPPSLQAKLAANANRSAHSPSPNHAVLGHDQRIDSSASASLFVSAAARPGASPGTGMGGLAARRGIPGTLGAPSPGSPSATPGAGMGARRNRPGLKLSDMGVGAGDGLDTGSAPRSGMGAGTGRRAPPPGRLPDTTDASKGSDGTAQQNGAMSTPFSNFSKIVDPSGRLNFSGKAVLHASGVEFGNGTSFKINMAELELLDELGKGNYGTVRKVRHTQTHVEMAMKEIRLELDESKLNAIIMELDILHRATAPQIVEFYGAFFIESCVYYCMEYMNAGSLDKLYGERGSVPEDVLARITGSMVRGLSFLKDQLQIMHRDVKPTNVLINQKGQVKLCDFGVSGQLEKSLAKTNIGCQSYMAPERIKGESQNMLGTYTVASDVWSLGLSMVETTQGTYPYPPETYSNVFAQLQAIVHGDPPELPAELYSETARDFVAKCLEKVPSRRPTYAQLLQHDFLVQDAAKGEEGVDMVGWVARAIAARAHKKEQAQANGVASPPGSSAALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGG5</accession>
    <name>W3VGG5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_06344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGG5"/>
    <dbReference type="HOGENOM" id="CLU_003442_0_1_1"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="703"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1266" mass="141123" checksum="07D917B11D54B902" modified="2014-03-19" version="1">MPFDVGALSLHVPLGAAWRFASEVAQVGWSISALITELTGCTESIPTDVLPTVAAKNPTRPPVQANASPLASLTYPLPPHSAFSPAVKPGFNLIIPVQGRRYSTVFQTSASHLNELRHELLSAPRSTAAMCGPTSHQAPYPLLAEQATRPVRPLPIRSIQEKRIHEFIGGQFASDNVSSLLYAGRTNAAAHVQIQSWSPSNGTRPNFAEASAQTFQPCRIGDKFGPSWSNHWLKLTLTVPAEWADLDGVELEFDASCEALIFDQHGNPLQGFTGGQEFDRRHDFPLPKGDRARMGAVYYVEITGNGMFGIHAKDTRYYDLGIGSDPDPHRYFELAKVDLVLKRLEAWQLMYDFTTLQQCVEELPKDGVLQNKALFIANEIMNTFRRSDVSSIARCRQLAEEVFGEAWSSSASSLFAGDAEIASKDNKALVWSLGHCHIDCVWLWSFEAAQQKVARSWTTQLALMERYPEYRFTASSPQQFKWIETLYPSLFERIRAKVKEGRFQPIGGLWVECDANMPSGESFARQLLYGQRYLQSRFGTTSNVFFLPDSFGYNSQIPQLARQAGCDYFFTQKLCWNRTNTFPHCTMMWTGLDGTQIVFSQSSIPNYNSRCGINDMIKATRRNPDLGVQPSCLHLFGFGDGGGGANPEHIERLRRTRALHNNGYTEVPKVTLGRSAKDFFEHVLETTRNGDRLATWSGEVYLEFHRGVYTSQAEMKKWNRLVELRLHDIEWLCTLAAVREAGYSYPHERLLQVWEPFMLGQFHDCLPGSSIRKVYDDMKNTYARLTVEMDQLQAEASAVLHAHQPGRAASADPVLFAPNTLGMPRQEVVELDAAAYGKLQSKPCVLQKLQNGNALLLLQDTNACGVLRHAVPQSQQGSVSARQEGGAFVLESDDMRLCIQNGRISSIYDKSERREMVAFGQSAGLSISEDYPPEFDNWEVEMYSLDTVEQLAFESVQIEEAGPCRASLGATIAIGEASRARVSIFMDAIPLIPQLANGEQARTAVQIRMSIDWHESHRFLRFEIPTTIRADTANFEMQFGHVARPTTRNTSWEAAKFEVCGHRFADLSEPNYGLAILTQTKYGYSVEGGLMRLSLLKAGAYPDSQMDRGSHVVDFALYAHRGSLMDGDVVAVARAYNAKPVLPGLLREGCDTSAWECPVRVVQDSKARYSQVVLDTVKMAEPRLDGGKEGKSIICRLYEAFGTRSSVTLECDLPVKRVSISDLLEQDHVDETRALNEAGALSSDGRLTAVLHLRAFQFMTVRIELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGG8</accession>
    <name>W3VGG8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGG8"/>
    <dbReference type="HOGENOM" id="CLU_1305693_0_0_1"/>
    <dbReference type="OrthoDB" id="2954648at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833031" evidence="1">
        <location>
            <begin position="18"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="207" mass="22847" checksum="51308A4E55C5DFD1" modified="2014-03-19" version="1">MWSFGLLAAFMPLLSAAAPTLSARNNFHYKIDPKCPQGTTPGFEVYTARYDVPAKRFYEKVGSFFDEAWYIGLPPNATRGPDNTPGSVREIDFAGTILHEQLIKYIRKPALLELEWHLVNGPINVTGAVADDPPDEKILFGSYTEDLRVESICEDTATFITFTGRYCFDKPGPAYKVFDVAHSSSIEAVAKDLNATLLEGNGTCPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGH1</accession>
    <name>W3VGH1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulphur transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGH1"/>
    <dbReference type="HOGENOM" id="CLU_037802_1_0_1"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS59897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="49579" checksum="E79FA843B1F8A12A" modified="2014-03-19" version="1">MDETPNSIWTLAPAEPAAMDKCGNMESSDSEVLTKRPIRILRAQVAIIPIILISPIVAYVWLGTFSTVTMSTGLAEFTPYHSLAGGLMMAASLHTLLSKLGLVLGISGFFHSTVTSTLNRAGLRKDSTAQSIYSTVAPYFTAGIFAGGIILGLARPRIETGLGVSILDNGGAVRSNSLLPSVVFGALVGFGTKLGNGCTSGHFLCGLSRFSLRSLVATATFFGVAVLTHVFNVFNVAKSATTTQALGSAFASRLPATFPKPDLATLLALQLPALVYLAAPSALQSGEKSDSTSKTRAAKQLLAAKTMALAVGVHFSFALGVSGMMRPSKVLGFLSLSPALVSSGKWDPSLAMVAIGGIIPASIAYFQQVKPKQDQLRRLGSSSKKSQDASSRLRPKLSLVAPEWRTPADPSKIDARLVLGAIFFGLGWGATGLCPGPALASLASLGAEAVGRGSMSAVSDLFVFVATMAASGQLAARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGS5</accession>
    <name>W3VGS5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGS5"/>
    <dbReference type="HOGENOM" id="CLU_269063_0_0_1"/>
    <dbReference type="OrthoDB" id="2593174at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="765"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="897"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1198" mass="127293" checksum="8C66DBE507C2AEB8" modified="2014-03-19" version="1">MNASIGADQSGLSDLSAASDLSMAEYFADDSPLLTDQQEHRTTQPSSAVLSPPSSSRLAPTTPVPRVSRSSPGPVGLTPAKLGGESSAAWTPSPDASSSRSATRLSVARKASPRMAKDANESMGSSLGTFDYSNASFSESFLRQAGAHMLAGLDEATQRSSPSPSSSSPRYRTSSSPTVTARPLRPDPRTPFTGKSLRTRMAEAGMLDSPASSDGSSPSCSPTVRTGYNGTQVQLGEEDIQDAQPSPDASLSPTRSPASSHQPGPALHSPSIASRLHQANDYSTELAAHGDWQEGLSMVPEESYIQDTSSIPASPANQSDSAKLQHDSSAQDVVEQENSANASTHSLPYSDASKAVELPPLPGQVTPSPNRAVLNPLGESSSPAQSKAASPSPLPQSKPPTPQSAPRSTNTPKSFMRLRMVTPARSSPLSRVVNFSPASSSSSRQWQSPSSHASTEGATANVTSPRDWPHGGTSRILPSSPLAGAPRRMDSPSISFSSARNAPQTPSSTEKAASQDRSLATPAERSFIESPAKESYASPYPETPQGGLDVIKAASTPSHMWSPATSASFATPASQRPQQATATPHVSSPAEKLAIHASLTPEAAFGTPKWSPSPAPAAAQPRDGIKDAVASPQATSESPQIDEHDSRSLSSSCSSSSGRKQSGCTDSSREVEPAADTSSDAAKAHPDVSTKREREVSLWSPQHSDSPSAARFSRMQLARLPTKPVAELGVAELAGVASAFDSLAELSDSRVARLLAQLQASTAYIDSLETALDAKERDEAHLRATWDAKDADLDEVRAALTQLSAQYAELVADAEAKDARMQGLVDQLQGKVERAGGQRDAELERQLEEERRLREVERRDFEVRMRAIRSAPTTCGAHDSPAPTADGGVGAERASEIEQAKAELRATLEKDFALEEQLASRSLSGAAADERLTAGNEVELQREVESLTAELDRRFEELCDVRAELGDVAAQRDAAEDHAAQLEEDLAESAASSELATLREQLAGKNAEFAQLDAELATLRLELADKDAKLVRLGEELLSARAAVRDAQPPPQPEPQQEETTRGSERVVVLERQLANAELELVRLRKAHDALAQDNVHWSIALAAKQLELGMVKRNARFALKQPKPNLLPESLKASRKPQKSQETDKADKVKKVDKVEKVLEVAEPAFPSVPTSQPAAPNRAREHARQLLAQRRALLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGS8</accession>
    <name>W3VGS8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGS8"/>
    <dbReference type="HOGENOM" id="CLU_152663_1_0_1"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150154" description="Protein kish" evidence="9">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="70" mass="7784" checksum="7688DAF46AFA3495" modified="2014-03-19" version="1">MSALFNFHSLLRVVLLIICTCTYVRATAPALVDRNKEGFLGVFFKSARIGERLSPYVSLACLVMAVYEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGU8</accession>
    <name>W3VGU8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGU8"/>
    <dbReference type="HOGENOM" id="CLU_602922_0_0_1"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000091">
        <property type="entry name" value="Zinc finger CCHC-type-containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042246">
        <property type="entry name" value="ZCCHC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="446" mass="48506" checksum="6CADB38C69FFFCAB" modified="2014-03-19" version="1">MTRYTKLDGRHSLAKKMVDSDSEPEHDYTVASASSSPVKVEPVAESASDSPSKDKKSKKEKKERKEKKDRKSKKDVSDEADGVDGETGADAATTEPAASTSAAPSEPDAPATSEPIDSEASAKDAEPPTVEKLLKRAKLLKLKMKKAKNDESKKRFQKMARDVERQVEQMFGSFEYGPKGQLIRLGAPQTDTMWQSRHKGEDWSAPSASHGGDGGWGARAGYSAANSASNGWGQNDEQRRMDRRDARREERAEQRQAKLKCFACRGMGHSAKDCPNALDAQSIALKSDRADAPMVGRDAVGICFRCGSTEHTLSKCRKPALKHDELPYATCFICHAKGHLSSKCPNNAGRGVYPEGGSCKLCSSVEHLAKDCPLSLRNEGKRNTDKGAKSLVHQVIVGSTKESNANGGDEDDFHSFARKRVQVEQESKSADPPAKKHKSSAKVVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGZ7</accession>
    <name>W3VGZ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_06071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGZ7"/>
    <dbReference type="HOGENOM" id="CLU_002265_2_0_1"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00596">
        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="753"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="995" mass="110745" checksum="A1F8CB6807C9CB9D" modified="2014-03-19" version="1">MTSQRQILKRAALLPFHCQIVNSLVPAEDDSPDEGDALVIIARGLGLRRIVSTVLRIYDSPNSLVILVNATSEEESGIGEELTTLGIRKPGLRAIHHEMPAKQRSEMYLSGGIMSVTSRILVVDMLSKRIPTALITGLVVLHAEKVTPTSVEAFIARIYRQENKEGFMKAFSDNPEHFTMGISPLQTVLSQLRIRKVELWPRFHQQTSKDLGQRKADVIELHQPLSRSMRNIQTAIIECLDASLSELKRGNANVETDDFSIEHAIFRAFDVMVRRQLDPIWHRVSAKTKQLVGDLTTLRNLLNYLLTYDCVTFNSYLETILASNTTSLRGNARQNQSAWLFMDAANVIFHEAKKRAYIWDEARRREANDASDAHYADDEEALRQAEHGAAAQSEAPALGPIPPEVEPILEENPKWQLLQEVLDEVEQEIHFTSTGSETGNTILIMCGSERTSMQLRQIIATMDECPPGEPGQKLLRQLLRSYFLWKGGLGKLSSDQGASNQPGGDSRNAHSSAAQRATASDGSINEALKRKLAYQKGQQSNANKRRRQRGGSSAAHAGGRFSSATDASGQASFQAEAAQVSEFLASAADSNEARAGLADAPIDSEQISDDIDEVEFDAFFGMLSMENLVVVRSYRGDQDDKVLQELRPRFVIMYDPDPAFVRRVEVYRSTNPGVGIRVYFLIYADSVEEQRYLSSLRREKESFERLIREKSMMALPLSADGRPIAEDADQRFLRTISSRVAGGQRSATAEPPRIIVDMREFRSSLPSMLHAADIQVIPCTLQVGDYVLTPTMCVERKSLTDLVQSFNSGRLYTQCELMCVHYQHPILLIEFDQDKSFSLKSTSDAKPGGRATSSELDIQAKLVLLTSSFPRLRIIWSSSPFATSDIFAELKQNFDEPDASKVALVGLDDVLEAEGNGGSDPVKRAEWQSSSEHSYNLGPQDLLRALPGVTTKNFRYVMSQVRDISDLCNMSEEEVGELIGVEPARQLSRFLNQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH55</accession>
    <name>W3VH55_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_06050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH55"/>
    <dbReference type="HOGENOM" id="CLU_016733_10_0_1"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="509" mass="54664" checksum="05569CF9F928848C" modified="2014-03-19" version="1">MLTRTALRRTLRLAAAARGRSAPLLARTYVQSSTLSTPIVVGSTSTTLRSFATTPRRLATEVKPYLLADVGEGITECEIIKWFVQPGAVVQEFDPICEVQSDKASVEITSRYAGTIKRLMHKEGDVAKVGHALCEIEMQSDGEAAEKEVDQEQVEVTGVSKESEFGGVEMEGFVSAEHKHSGASPAGGAREVLATPAVRRVSREHKVDLSQVQGTGRDGRITKEDVLNFVQRGSQSAQPSASSSSPTPSAPVSAGGTTEVIDLTPVQRAMFKAMTATLSTPHFAYSDEIDVTELDSVRKMLSASIPERYTQAGEASYTKLTLLPLLVKAMSLALNDHPMFRSILNADQKLVRRSSHDVSIALTSKVGLLTPCITDVQTKSIYDLSGFITRLQNLAASPKGLAPADLKPTGTITLSNVGAVGGGTYTHPLLPPTGQLAIGALGRSRILPRFASEIPSLNCNDPDKIVRRLIMSVSFTGDHRVVEGADLARLVNRWKQLVENPSLWLGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHL4</accession>
    <name>W3VHL4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHL4"/>
    <dbReference type="HOGENOM" id="CLU_026730_0_0_1"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="6">
        <location>
            <begin position="316"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="481" mass="53299" checksum="ACBC0F991233FFAF" modified="2014-03-19" version="1">MQKLAMQPLEASWTPNFRPALPITSICLAWLFLLCLTLPARGGAWRMVRLASFPAIVLLSLQLVLDRRMTLGNPLRDLALPILAWTIICKAAEICIVFAAGGPRPIRPFHKGKLVTCMGEDYAGYEWKIVDAPKMASWARVVYALDVFLLRRVGTSAIRPREGRALEWSLRGLNDWARFLRQNRCSPAQIPAHSTVRRFGQPEMASYAAVLQMLFAVVSLRWIHALSTPCQVLDVYGFWIPSSPASRSWISLLPATAVKQVRISGIPASAWKLPLPTLLSVVVTVGGAICLLPSAAEGLLLLVWKPRPATSFLASFERPLTSPGLARLWARSWHATSQRDYLAMASLLPGSRQRTLQLLYVFFWSGVQHSMMFARLRIPSGTPLTARAVLAGMVDPGMVGFFLCQAVGILIETAALEALPATWRKQRLLVSLARRAWMYAVLLLPGCMFVHSILQHRLITCAVLEGFSPRALALMLQGKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHU2</accession>
    <name>W3VHU2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteophosphoglycan 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHU2"/>
    <dbReference type="HOGENOM" id="CLU_013698_0_0_1"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="302"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="944" mass="103778" checksum="5E01107B1EFC0E91" modified="2014-03-19" version="1">MDGIVYPQQGESSKGHYAAFSHGGVEGFLPAMNPSSQSELERLPSIEFSASQGFFGQLDSSPTPRPPLSSDPSTSPTLHTHYQSPYATSSRTALSGMDPMSTLGHGSHPAFTRFRDHQQQNSPPARSIPDAKLWNDPAVRGDPIGAGAKATSQTRGSNPTPQMRIDLPSHHLDSEDRARRAAEVDRRNKLREQEKVRRKLEIQKQIDDGFAALSMETATPLQQLQAKRDEEDKLRRRRALEQEIQNGITAIQQERIRQRARVESDRQACRQWLSDLQPAKASAGTSTASHVIDAIDPYLALGRQIRGFWNHSRPPAAAHLRRDEVVADVQRAIDRKWPGQNLKVAAFGSSVTGLLTASSDLDLVLLDPTRPYGVGTPPDLCGSPKGFVRHSAGMPDWYSVHQVAHALRNSNKFAPVQPISGANVPIVKMVHSKHGIPADININERFGLFNSQLISAYADLQPGLVRPLIFFLKHWYSQRDLNDPAGKTGSMTFSSYTIALKALQVLQVEGLLPNLQSPPLLNSLQIHPSFLFARPKRPRRRNEKKSTAASDEAVRGGLNGSWRAQQDPTAPKPYDVTFVRSQIDASPYRAKALAIAEQSDDAPLASAPSPSSTDGADRLLGKMLVAFLRFYSRLDRKAQAISLVNGSPIQRRQSSQPRHILFDSADEDETSEHGEHSADGAEADVWAGDELVVQDPFIVDRNTSRNIKSKSIERWQSELDHALHFLGFDGRGSAPSATKLDDVPLLLDLCIPPDVAAFMEVDDVGSRASAKGRHAAKSKEPWRSQEEAQAQAREIAKQAAEKLRSEKKRRANRAKASEARILREEAAMVQDIVNDMHPVQVSDSKEDNNQHDVVPDRRQEDVPGRHNPIPSTFSVAPSTGKASAPTRGSIHHDTNGLHASEHLAQDLALSPTVSSGTSKTDETSSSEDLDLVALRLKYGDRFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHW8</accession>
    <name>W3VHW8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHW8"/>
    <dbReference type="HOGENOM" id="CLU_402316_0_0_1"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="82125" checksum="9D56CBADBE2D718F" modified="2014-03-19" version="1">MSYSNPAQGRRTSSDLNTRYQRISSHQQQQQQEQQWRQYQQQQQQQQQQQQQQQQQGAPQHPPRTYSASTPMWTSQPVPEPPLLPPLVDLANWIASLPPIQQWPSLLVDRLLLAPVSQLLRATRDIILSPKTHRIVVRLGVLATIFWFALGAAIVSYIGFYRAWVPDVGLRKEIWLQYGHNRPPFAHLDFATPTSASQLREPVVSSSSSKPSTDITGEFFAQDQAYDVTLELSVPLNPANLDLGNFMVDLDLKSKADRSVFHVSKPTLLTFSLAPIRAVSSLSQLVSRNAPSPSAPVNSQLLRIPLLRRAVLRPSSYAPPLSSTPPDPLADRKVTHGQLSVGRADAEMFWMYGGNHNTLAGIHTLPGNGKVVPIAVGSHSSRGELQTYSASLRFDAHLTGLRFFMYHFPLLSFFTFTTLFLGFEMATALTLWAVAAIYTSSMTVEPVSLDTEEHFQPTKPSRYGGARRRGGGDDDDDNGDTSGKAEMDTPSGEESTSFERRFGRRDELRSDEDETETETETRRRFKREYDLPRIKTEEFDEEDIRLGADDDVQEEMRLRSLESLEAKDAADLAEAIRQSRMRDVLEARRMGGSTGVGTSAGTVMVGEGLMDIVDPTSPISPEELSEIQLSRRVLDRLDEETEEDTDVGGSLTGEDASSNASRPTRPTSRAAAVVAVGAGAGGETDPWEDLEGESGSGDGSSGGSRVNVEDGKDTGAQSTVGGSTTSGARTVRSFGATTNATGTTGTRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI26</accession>
    <name>W3VI26_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI26"/>
    <dbReference type="HOGENOM" id="CLU_015564_0_0_1"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="682"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="791"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="902" mass="100282" checksum="40A4406BE7323E4A" modified="2014-03-19" version="1">MDSDPSPPSYRHPHCSRTTSEAQPQVPDAERAQLLSCRECQKRKTKCDKQIPCSSCTLRGIICQPVAVDPTRPRKKRFAEAELLARLRRYEALLSSAGIDFSHAEVDSKLSASSSSPTPDASVADRKRQRRSGSHISLSSQAGVHGVAQPVDQDVGATPSGSTIDPDIGHIESILETVTPFQSGSHRSTPRFQTAGGALMTTDAPLDKSDLDLISETSLHQDPAPAHAISSTLVIHKFVDLMFPDDGARNLTFDDHCPGEALIHPDASLMFRLLHIYEQNIHPLVKILHIPTVRESLCDIAAHSVDVAAHNHALFFAIYSLVIGTLPVHESKRLLNTSDPRSVAENYRRNAQTALCRASIWRSSHLTTLQAYMIYLLATRMDVDPRTYAIYSGNALRMAERLLLVYGRRNAVTGSAIGNSDLEREMVRRVWWEALLADMRASEKSGITSNPTLATASTRLPMNASDVDLSQLAESMCSNARQPSNAAWTRLRSPETESLFLLMRCEFAQFQLHPPWSHQYKDQQLQHHPFRRTGAYRQQVDPHKRSSVSDLSWRLSAVDHFERYIFARYFDRPEIATSMILQYAQHHARMNIARLRLIVHLNDRRIENEGEIIRACIIQVEETAKLIAERKFVRYQWCTFSYLPFFSFVVLLDILRRHTEGPLVDRAWDAIEDSAVIWKPDLHNKDSKDQGAQVPTHNATPDNGKGTQDHSTINLYADPSNVKDGKAKLRVRGIMLASLMVAAWEKRAQALMSRAARQANGGAPFIPTEPQVVSAMRSAAALKQDVPKSTANPAFQVGSRPDHAPPWQLGSAEGSLGNKEAEGFANRNDRAAGEAHGGSFTAFREQPPGSFASTLDDMNNLNALLQSSVDLDWSTWFRQDWDTPSSGALIDGISPVSFMPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI58</accession>
    <name>W3VI58_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI58"/>
    <dbReference type="HOGENOM" id="CLU_341066_0_0_1"/>
    <dbReference type="OrthoDB" id="2555666at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="856" mass="88519" checksum="672969039C8500CF" modified="2014-03-19" version="1">MAPVIASTGQTRSRLPPKWMQPHRTTPKTVVADSKPLERSAPAVTRDSPVRWSTHTLAGDSNDTVRSRAESTTSTYVDTFAHRRKSRISDLTCIDHADSTDIANLTPSQSLTSSINDLSLTLNDDDDAVPPSLAMPHDDKLAHYNRSDHIPSSDAALNPATADSYSIRDDTDDDDEDDDDLAERIDRLMAATMEALEASNALVLDTLASRAKLAQLNAMEAALDSHLDTREAHLRRQITAVTDMSDFMARTTSELDKLTRLGQASRRPSVDPSSASPITALADAAGLQVRGAAAAGIVQAQDRDATIGKTAAKRLERMLHAPSTPNASPSSAASPERRDPNPSRRAFSISNFASVQSSIAEEAPVEQQQSTSQEPASASTTPKLAAHASSDSRDGTPPKKRSVSYDSRASSGIKLMANLGGPSRTAFAAGAAFTSAAVTAPSIAVGPSAAPLAASVPAVGKSGAGLIDFNEPATSRVRSSAKPVQRPSLMAALRQDSAQPSESSASMTRTITSKDAANATDPQAISGLPNYSRTTSLKAEASTASASKSAESTLAALLGMSTAPASASVSSRNETPSDSSYFDSATEGSMLSASPPTPGSIHAIRGVLATPWKPETRDGSVPDFETPSSHERPSTDQATAKLRRVSGQYSTIVSPRASLSISDRERAGQLSSHLAELRAERVTWNPIAAAEAGTTGAPLAGSGASGGGALRALQKLNEMSAAKLAGQGGAAGEEEGSAWYAGGKRVSLGLGLPSFSALRPSASQSTSTAGPSEALPSPSPAPAPARPPAAKTESGADDKLPASVASEGQDADAANTSSSSLLGGGWRSWTAWSAASTTTGSETSTPQRWSGRTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIK4</accession>
    <name>W3VIK4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="802"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1221"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1250"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1291"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1328"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1355"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1481"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="210"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="875"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1507" mass="166176" checksum="12A1540B962347D1" modified="2014-03-19" version="1">MPASQLNPWKSTSVCQPCSAGNLQTSTSLGPPCSEASPVVSSDRRSGPFIPPAIGVCTSLRESHPSTMSSRSVSTGASTPLEAQGATSPTAHSAVDMPADDERGVNVERAKSEFAMLETSLSRQSHTYGRQQTEQPKDVESDAANADDDEDFDLVQYLRSTQSENSKAGIKSKHVGVSWTNFEVLGNDSMALNIRTFPDAVTGTFLGPIFKIMAALNKNRGRKLLQNFNGFAKPGEMVLVVGRPGSGCSTFLKTIANQRGGYIAVNGDVSYGGISAHEFGKKYKSEAVYNEEDDFHFATLTVQQTLEFALNLKSPGKRLPHQTVKSLNKEVLDTFLKMLGIPHTANTLVGSATVRGVSGGERKRVSIAECMASRAAVLSWDNATRGLDASTALDYAKCMRVFTDIVGLTTFVTLYQPGEGIWEQFDKVMVIDQGRCVYFGPRDKARAYFLDLGFKDYPRQTSADFLSGCTDPNLDRFPEGKTADDVPSTPERLEQAFQNSQIYRDMMQQKQEYDAQLEADNNAEKEFREAVLEDKHRGVRPKSVYTVSFARQVQVLTKRQMQMILGNRLDIFVSFATTIAIALIVGGVFLNLPETAAGAFTRGGVLFIGLLFNALTAFNELPTQMGGRPVLYKQMNYAFYRPSALSLAQLFADIPLSISKIILFSIILYFMAGLERTAGAFFTFFIFVYTGYLAMSALFRLFGTVCKSYDTAARLAAVIISALVVFAGYVIPRNAMYRWLFWISLACVGTYIVPRNPPGSNAYPNDVGANQVCTLPGAQPGNQFVAGNDYLRASFGYDSSDLWLYFGVVVIFFVGLVAVTMIAIEVFSHGSFSSALTIVKKPNKEEQKLNQRLKERASMKEKDASKQLDVESQPFTWEKIRYTVPVKGGKLQLLDDVYGYCRPGTLTALMGASGAGKTTLLDVLADRKSIGVISGDRLIGGKKIGIDFQRGCGYAEQQDIHEGTSTVREALRFSAYLRQPQHVPKEDKDAYVEDIIELLEMQEIADAMIGVPEFGLGVGDRKRVTIGVELAARPDLLLFLDEPTSGLDGQTAYNVVRFLKKLAASGQAILCTIHQPNALLFEQFDRLLLLERGGKTVYFGPIGPNATHIVDYFAERGAKCPEKVNMAEYMLDAMGAGSMKRVGNKPWSQLYLESDLFQENLAEIEKIKQETNASAKANEDEGKKKKKQTEFATSFGTQVKVVLKRSLLSTWRQPDYQFTRLFQHAAISLITGLCFLNLSNSVASLQYRVFGIFMATVLPAIILAQIEPFFIMARSVFIREDSSKMYSGTVFAITQLIQEVPFSIASAVVYFLLFYFPTGFQTGSDRAGYFFAMLLVTELFAVTLGQAVAAISPSVYIASLFNPFLIIIMSLLCGVTIPYPNLPHFFKSWLYWVNPLTYLVSGLITNEMHELPIRCTESELARFQPQSGQTCTQWAGTFLNAFGGYLENPDATADCGYCQYSRGDDFYAGLNISFSERGRNIGIVIAFVAFNAIATIVASRYIKYANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJW2</accession>
    <name>W3VJW2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJW2"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="481" mass="52983" checksum="1347DBDEEFCF0F94" modified="2014-03-19" version="1">MTVGVASKLLDAPFSHVINGKSVDAKGAKMLDVIDPATEKVIAQVPIATKETVDQAVDAAQAAFPSWSKTSWDERAKLLEQYGEEFKAMTPELVKLLTAEQGKSIMFSQHECESILPWFTELAKIRLDEKVKHEDETHRAIERYLPLGVCAGIVPWNFPILLMLWKVTQALITGNCIIIKPSPFTPLCDIRIIEAAQKIFPPGVVQIVVGDDNLGPWITEHPRIQKISFTGSTVTGRLVAKSCSATLKRFTLELGGNDPCIVLPQQSDMATAAQNVLLSAFFNSGQVCIAAKRIYVHEDIYDEFKATLAQVVQNFKVGPGNEEGVMFGPINNKMQYNKVAEFFEESKNKKFNFISGGEVEKKEGYFYPLSIVDNPPEDSKLVQEEPFGPIVPLLKWKDEADLIKRVNDSQWGLGATVWGSDNAAAERIARQIESGTVWISRMVSHHPAVPFGGMKSSGIGAEHGTAGLAAYCQVQAIWLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK60</accession>
    <name>W3VK60_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK60"/>
    <dbReference type="HOGENOM" id="CLU_723856_0_0_1"/>
    <dbReference type="OrthoDB" id="2556046at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="325" mass="36219" checksum="3336E814B5A9C051" modified="2014-03-19" version="1">MDLSNLRASLREEEASTRRRTSHLRASEDELNGVFRTSALGLTTLYRQAVAASKASYEKGYAHALAHVLELCDNDRDWLKGYLQRRIEAIEAVEDESDDREPPPTQHQDAEEIHSSPAVARNHASTSQPRPTFEASPRHNKRTRGATSTSRTAAVDDEQHDRRISNRGASSSRTRPTTTSASTSAFSANFDFAAPIAYPDASAGRGESSASRTPRTTSRTETPSIKTSNPAAQRRRLHKLKGLRAGKDRVLEVHADRGPDDMDDGEEDEGEWTDDDEEARGRRVGWADKEREDEAEARVVERLDRRKRRRTFNTTAAAGEEGMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKH0</accession>
    <name>W3VKH0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60S ribosomal protein L13a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245176_0_0_1"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="951"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1185"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1465"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="833"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="959"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1080"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1124"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1198"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1466"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1479"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1500"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1579" mass="173152" checksum="37C11B1F60F87981" modified="2014-03-19" version="1">MFDFAQHLPRPRLQPRPLSAAVWPRRIVTDCWPSSSTLPPAREAEPGSEEPTGPTQQFSNSSNFRGHIIARPRSHDQITLGPGRPESQVSRCVREWVFETWLLVIIFDTTTTVKKHIVKVCIYIYAYTATDHLSASRSSLHAVDHTNNLGMDQSSPASFARIHTPTARIAFGGWRRRCHDLLSVDMRAEPLTSRPGSFDRDTRQKDPDTRSHEGHPDVAHQRRAHLAMSLQQANPYIVDGKGHLLGRLAATLAKELLSGQKVVVVRSELINVSGSFFRNKLKYHAYLHKRHLVNPKKAGPFHHRAPSRILYKAIRGMLPHKTARGAAALQRLKVYEGVPPPYDRKKLMVIPAALRVLRLKPGRKFATIKRISHEVGWNHMETVDKLEAKRKVKQQAYHERQVAASKKRAAAQTATADKLKDVNAQLASPPPSHSQDSKALTAMPRHYTEKPEQCKGSATSNAAEVLLLPRLQVILPCRPARRGSSTFLRTVITVGQHSLVRKLTPPSSLQHNLWNRRGAAWRRYCAGIPAHRLQIGLKRRRIDANRTFDPLSEIDQRAVHTAATTLRDEQAQPSSPAMRNSTTYIPVPAGAPALPPAPAQAASVPASSMPAYQRLETPMGRLTERSSSPSSAHEIPPSLHPRWHAAASPAPAPAPEPAVRSSAPLPPRLKNPYDRTMPSVAQETLSVQSPSSSNAPGRVRFGPGDPLFTANAPAAYPNPYSHQQPLPDRTLDTDTAGTRSIPNRTTARPEDVSDPTQSIVDSRAPASSHGEPGHEFDDCPGCRAELEDAIQASLQTAKQEEESRRRAPLEQQELDRLYAITSEEEERRRRLAMEEEALLLQAIEDSRREAEMQSQRHANDEDVLLEESRQHALRQRDQDAIKESEMLQAAKMASEMHEQQRLERIESLRDAERKALQLSLQEQEEEWARRESAERSLLEFLEQRGHYQDAAAQLPTPQRPSSTSASPDPTSRPPSAVAAGDLEAEYWRFSGHDEAYRLALQMQQASLEEHRVHTRPASSGTRVRRPLPQTPTLRSESSSSQTHPVDSDSLHNVAPDSSTSGALGGAQVHALPDPPRPALQQRSSSSSSKQSQSVDPLPLEQAPSPSSEWYNPYDAVRTTAGSGDPACDPSDPAPASYSIPKRVSSQLSTTTRDEIVASSSPAPEQKGQRALAGIDFGYCSLPFAPNLDKPAQPSPPQSTATLSTSSHSTSQSGQKARFPASIVLSAAGKASHTAELDAAYPQRSAGEGSSGSFYVIRAHSWKSLLRALAWYGNTRVEASPEDVAAASEHRSGRCLLRAEIEFVTPTRVDLGMGVGEYAKAAHTSAGMPKHPSPAHVALCLSLLPVSSGSSSASSKEAGAWLKSDTYRAIKHESRRLDAWYAGKGSTRRLIQLSRQPPALPVILVQIAQVLHASHAFSAACPSSGSTARHSPRDLHHAIERHDEGFVRKQKAMLAAGSALASQTGGLSNASTASLASSNPRFSLSGPSRFSGSTEIHRESNEDDFGDEDDQDVDVDDFHLLEHGLAGDGSFDAQDKALMGKRHRFKAKVKRRLAKRSADGRVVDEDLAAWITPFDLSQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKI4</accession>
    <name>W3VKI4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKI4"/>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="82"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="567" mass="61130" checksum="9A9276D0A11ABE72" modified="2014-03-19" version="1">MSHSPVDPVKVGDETIAKGDGANQHVKPANGDQLEKQVSPLESEVFSRPDGASVDDIYERKVYILNKVMNDHIGMGKVQWQLFLLSGWGWMADNLWLQGVAIILPQVEREFNIQSDVRWMTFSLYCGLILGAATWGILADVIGRRPSFNITLCIAGIFGIAGGAAPSFVGLGGLLAALGFGLGGNLPVDGMMFLEFVPAKSQYLLTLLSVFWSLGQLLASLVAWAFIANYSCNGNQSNTVTGPNTVACDVSQNKGWRYSFYTFGALTFAMFIARYFVFNLPESPKYYLSRGRDADAVAVLKDIAARNGKPLGDDVISVEIFRSAAGQEASMDAQEIEHKPKGMKRITSAPKEFIHNFKGVSFTPDLSHVRPLFFGWRMAVTTSLLWVLWSLIGLAYPLYNAFLPIYLSEAQGLDGASDVNTTYRNYAIISVCGVPGSIIAAWAVELPRSGRRGALGVGTLLTGVFLFLFTTASTEGAVLGYNAVTALTQNIMYGTLYCLTPELFPAPHRGTGDGIAAALNRIFGAMAPIIGIYAGGTAPLYVAASLFLLSGVLSFLIPLDSRGKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKJ0</accession>
    <name>W3VKJ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKJ0"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="161"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="482" mass="53174" checksum="7E8DED5EB71C1F22" modified="2014-03-19" version="1">MLGQLDGIRSAGSNGESHAWQSDGERRERHRAGRHSKPVDLHLHGIGGDLHLHLCASTSSPSPRESSVEGRHNGVVPSVGPVVAGRAMSVLRRCRAVLRSALDAGTKPRVQEVIKHAHLSIPSSFHTSTHLHKDPKATNFDLKMTIPTREFGKTGEKVGCIGYGAMGLAAFYGEPVDQPTVNEVLSRCLEDGATFWDTSDVYSPMSSGKLGYNEGQIGEFFRTHPGSREKVFLCTKFIINLKDGKMELNGSREWCHQACSDSLARLGVDQIDLYYAHRPDPNTPVTTTVAAMKELKDAGKIRYIGVSEYNLEQLKAANEVVHIDALQIELSPWTPDVLTNGILDWCVRNNTALVAYSPLGRGFLTGQYKSVEDFEENDFRRYNPRFTGDNFAKNLELVDDIRKIASRKNATPGQIALAWLLQKSDAIIPIPGTKKEKYLIENNKAANVTLDKSEVDEIDAIINSFKVSGTRYGPEMMATVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKK8</accession>
    <name>W3VKK8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKK8"/>
    <dbReference type="HOGENOM" id="CLU_012062_9_1_1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="26"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="223"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="324" mass="33698" checksum="99C8C7EC856F4064" modified="2014-03-19" version="1">MTDPNQSIVDPVANNVQPAKAEDDAKKVFAGNLAFATTEDDLKSLFSEAGKVTQAQIITRGTRSLGYGFVTFATETDAQTAIQLLNKRDVAGREISVESAKPQSAADADKAKARKTRSKAKAKDSTRAPRRARADEGEEGAAEEDAAKQAGVNGEAVDADGKPSKSAKRRQKKKAAAAAATAAGANGESAQTDANAESSEAKTRAPKPKRGPKGAPTGELSPTLVFVANVAFSTTDESLKAAFGEYKVKSAHVVKRRGGNRSKGFGFVDFEDAAEQQRAMANAQNIQIDGRQVSLQVAVQSDRHNADAAADAADAAPAAPTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKS1</accession>
    <name>W3VKS1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKS1"/>
    <dbReference type="HOGENOM" id="CLU_1644447_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="161" mass="17157" checksum="3534D46BD027A479" modified="2014-03-19" version="1">MVAKGASSVSTRLSRPIWPRGIFPSPNANRSDSAHALVLLVLLALLALLGLFLARPKAMPRAKLTRFACNANLRALPPPSTETGQRSMAGIFVRPLHLLCSAPRIGAALRTLRSKDFLVLPTGPDAEPNQGVRAAIRDATQDPRIERTNAATAFQTACDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKV7</accession>
    <name>W3VKV7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKV7"/>
    <dbReference type="HOGENOM" id="CLU_122140_0_0_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14828" checksum="90F38EF84A91AD8C" modified="2014-03-19" version="1">MSSRIPDETLSQVLEKIQLQVYQTNQQLSALRAQIAAREREAKLNTLTLTELQAIQDPNAPFYRSVGKMFLQESQPVVLSELEQKQTAITSDLEALQKKQKYLQKQREDAQAHLKDIFSSVNRQQQQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKX4</accession>
    <name>W3VKX4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKX4"/>
    <dbReference type="HOGENOM" id="CLU_469280_0_0_1"/>
    <dbReference type="OrthoDB" id="3364568at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="568" mass="61267" checksum="53AAB4916B037F73" modified="2014-03-19" version="1">MNTSNHQQYYGGNAYANRTDSYAPLRPEGLGLGSIFPGQDSAHDSRLRQQQPQQYPSHHQHHQQNNAYRSADPLRDISALQASLEDQLAAMRLQSSHNSDAQLGYQSYAANQGGYAHQHQYAQQQQYLQMQLQQQFAQQQAAVQQQKIELLRLQALQKQQQQQQQLQYGHQQLYSNGDNSNNNNNSHQQQLAAQQRLLLSQLQGGHGELDMGSLYNTTAASAQEQRQAAQASLQASLRQRQVQQLYQTMGLENGAHATAPSYNDSIQQQQQQQQLQNILNRHTRPVSNEGAAPSRVPLDQRSWRGGAMAGEERMPTPPSHRGSSPASSVSDSRRPMRPSSGTAESIMSMRSRTMTPSIVIDDSASEGSRAHSEFDQVEGDQTPETSEEDLEVHTTPMSKATQMQLHKQANGGRYGSLGRAGANAGANAGANAGAGAGAGASASAPTSTSATPPMSAPKAIPRAIHLSAAPQHRAFKANGSSDGVQTINNAGLTLPPIQPRRQPKGQPSDFAKVNFQARMNSRLRKDAMSKLCASPRAASFGGNGMSFGARLSSAGSNVGGVSVMAAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL78</accession>
    <name>W3VL78_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MOB1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL78"/>
    <dbReference type="HOGENOM" id="CLU_038321_3_1_1"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24859" checksum="C3A2CA7C3EB59C11" modified="2014-03-19" version="1">MSSFFGLSKTRTFKPKRNIPEGTKQYQLKRYAEATLGSGNLRLAVVLPEGEDLNEWLAVNTVDFFNHINMLYGTITEFCTPSECPVMCAGSRFEYHWQDANSALYRRPTKMSAPEYVDCLMNWVQSQLDDESLFPSKLGVAFPNNFAAVVKSILRRLFRVYAHIYNHHFAQVCALSIEAHLNTSYRHFLLFITEFHLVEPRELAPLVELNDAILGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLV6</accession>
    <name>W3VLV6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLV6"/>
    <dbReference type="HOGENOM" id="CLU_994651_0_0_1"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000827">
        <property type="entry name" value="Related to pre-mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="272" mass="29985" checksum="11C67BCA15E2CBFE" modified="2014-03-19" version="1">MSGRGYDRGYERDERDDRGPRGGRGGGRGGGRDRAPPTTLFVAGFPPSMRAKDLAYEFERMGPLIRCDIPALKSATATPYAFIEYEDPRDADAAFRDMHGMSFGRHQISIQFAKNAPSANWRFDGPSRGPPPPPPAYGGRGGGRDQRDDRGPPPADLPPPRPQLSKEEQEEADRAAEERARRRAALRRERSPEPRRDDDADYSEERRRGSPRRDDDERRDNADGNTNGNADESAQNTHEDRPEAAADAAADEARDGADDGKTVQAEAAAGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLY7</accession>
    <name>W3VLY7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLY7"/>
    <dbReference type="HOGENOM" id="CLU_015810_0_0_1"/>
    <dbReference type="OrthoDB" id="2556539at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="843"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="565"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="88488" checksum="A949887DB8BD5850" modified="2014-03-19" version="1">MSECVQAGKQAGCAAEHVEQLDRESCFERLRLAVGEIASLGAVPDAAAASPLRFACFRSPVAAPLACLAALHVLNPLQQPKQQQQQQPPARPPNSPSSVPLQKLTHCLPPPAVCEESSSPFLLLAILVSTPCLSPSVWVSPSSLPDFEPRRVLRLSLLSSPPLGLLVVTRFDLASIGVRPKHPPKAAASESILSHPTSHPVTPHTSIVATAANMHFFSSIGLVAALLALAQLAQAAQVAVTQISCNYLYFTLSLTAAEARDAVYLGVYIGDNMISEIQFNSAYANTNTYQWYAPFFQGSGPTTSGTQDVTFRLLDTNEEPIAAYPRITQPLAFQCGTTLTTSTTALGTATSSSPRASNTSGGGSSGSANDSGSGSGSSSSTGAIAGGVAGGVAALVIVGLVAFCLMRKKKKQNQQQSRLRNDEADEAAFRAPNNDSTTSLATAPETANTPMMRDISTKNVFADPSTSAFSGAPSGTSTQYSALNNNAASSSNVGAGAGAAGAAAAAGGIGAAAIAARKQSRENTRARSPSHASDRRPSSEFSKDNSASPSSQAPPPVPALPTPMPAAASPKQNTMAAVPPANPSASAAASHPPYSASSPATANKDASVAPLAAGGAAAAAATTAAAAAAASNKDTKDKSSKWGFKRASKDTSTNKLPYPPAVPESSALAPSVETPSASSNSSTSKQSAEVPVPASPSRSFKVIPKPAAAPAAPAASTAGPSSPSIAPSENSLNRTPVFPPRSGPATPAGSIRGTNYSRAPSVASMTAGFADAPPMPSGASVSSAPVSEFGGNMAGVGAGRSFAASSGNSTKWHQQSYNIMPNFSHRALARSTQLDEDLIFGHLGMGLTPPPGPAGNGSETGSSKSRTDPFGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM34</accession>
    <name>W3VM34_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM34"/>
    <dbReference type="HOGENOM" id="CLU_1058345_0_0_1"/>
    <dbReference type="OrthoDB" id="2556589at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="229" mass="25712" checksum="5584F4CD1A8EB835" modified="2014-03-19" version="1">MIRDELLGNDSVASDTEPLSDSSTSKSEGEAESRTTKTLDSSFGEGDLEDRLSCSGIAHSLRHIALAFDEKSRELDSLRSMQQRHDEELAILQDKLTAAEQEHTARTMELQLANSSREDMEREIDALKQRLEEKDELLFVSDRVLHRLFNMIRVIKTQVDEAESLSPAVRSSDDQAQSDGTATKDSDESDTTEIEAQFPTLKSQAEEEIDRIVRGIAERYSMTSLDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM87</accession>
    <name>W3VM87_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM87"/>
    <dbReference type="HOGENOM" id="CLU_1195644_0_0_1"/>
    <dbReference type="OrthoDB" id="2552173at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="228" mass="24911" checksum="DB946F003041FEE9" modified="2014-03-19" version="1">MPVAAVGLLVVLSVESFKASSRFFQRRKSKKHGYSSLRTDSLGRPISEDGKRLSKNEAKALVAHNREIQRIRTAEREWRAKGERLPAYAEMDDDAIIQSLRRPSTAPASGRSSSSPSVLTVAAASPTEGVGAGPVRPRAVSTTSAGLETPASGVRAQREARSDDLAVSTFESLDGGAFSIRRRRTQTLVLPTIPSSESPEIEDIFQHDGLDWRRTTWEAPPIYDQVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMD2</accession>
    <name>W3VMD2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMD2"/>
    <dbReference type="HOGENOM" id="CLU_314763_0_0_1"/>
    <dbReference type="OrthoDB" id="2260578at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="929" mass="100052" checksum="2E4A7866FBECE061" modified="2014-03-19" version="1">MSLQLDPSASGGLQPLQKRSALACLPCRTAKNKCDGAPPPIIAELSAHLETKMPPPAGADVQLVSEHACTRCARLRLECLWQPSHRTGRPRKRARHADADDAASYLGPTGPVVTDPGSTASDGHLRQFGQIDNGSAARLSVADTADPANPFGLTTAPSSSLLGYTGMDLIALLNHSQHDSSRAAIQLDLDHDLDLDLDLDLDLDQLGPQIALHDQITPNALERSPYNPVSSLVITSLDQIHAPTCPQTSFSPSAGNDRDALLSTANDYASPSNAQQARSQFSALRARLNAVPRATSPSTTETKSVTPSSSLQADHIRAALQRYLARHDRSALSNDADTTAILEIGAHLYFSGFAKTVPVLGEASEFRTCVLDALPAQNVARSLLGRIIAVLGLSVASIDRLTAQSESSAVLDDLRSQARTLLATCLEGMSLKSDIPLDSVEALATLQGLLLLAYDSYGNNRLAQAESDMRAAVDLARRMGLNRVDAPDSAGMSDGPREQGAFHSRAAPLSAVRKESLRRLWWELYLCDLMLNVTTSGAIRRCLDSDHLEVAVHTPFDPGFADLRRSPPGGEGQSRQSLSQAYDIRIRTCALIHECVRQPEDPDDPDHERIRAIDTMLSNILIVAQRHWADASTQTEPSSHQVDARPRMPTSDARADVSCTRWALETRIELLFTAMTMLHASRIHLHRLAWFPDLTMDFVSCSFKRFDDSPAGVLSRAGPRSTDRGNAEVRQSMLSTSVTRIVSSADAIMRLVRLDQRMAVPAPWSDPGRGASDSQAHVPRGLPAHWPFLGCCNMVAAFGYVVAVAASGPEESNLPTYGDEIRLYGEHDVTGSENRGHGSVVAADTSALSAPSWQYGSPEASTLSNGGGNAGERQRSAMVWKLRAAISNIGFAESTLAQYSQVWPVCAMYQHEVAVCRDAIDSTGPTGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMG4</accession>
    <name>W3VMG4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMG4"/>
    <dbReference type="HOGENOM" id="CLU_2110029_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="115" mass="12241" checksum="03E0ADB1F2A11176" modified="2014-03-19" version="1">MPGAAPPATSIPPGLAAASPAEHPSFGRLRSLAFDQRPKLGWRHPSSLVASQVEQAEQAGPCPSTIQYTPGLDAAQPCPFLFWCPTPPQTLQYEEGLDSSTFLAGQRFHTIIKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMM4</accession>
    <name>W3VMM4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03587</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMM4"/>
    <dbReference type="HOGENOM" id="CLU_034765_0_1_1"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000092">
        <property type="entry name" value="Related to MRPL3-Mitochondrial ribosomal protein, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="11">
        <location>
            <begin position="179"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="327"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="446" mass="46513" checksum="674E6E376E643F39" modified="2014-03-19" version="1">MAANRSLSHAVRPLAHTPSASTSKQALLRATRPAHARAASTAVAAAAPATEAAAVSSTSYVHDPTPNAHLPRLARAEPELFAAVRPPPLSAFAALTARLGLLPSSLDAESRERRIRLVHQACTHPSFQALVDKINAAANLQLEPSAAASGLAKKHGATALDAAQFLPLPSGAVDHHAALATVGNSLLGMLATEHLHLRFPNLPTRVLKAAVSAYVGPITLADVAAELGLAGQGILRWNKEARIPTSTNLVHKRNGRGAAPKRSASSDASSSSGPMRSLLSKDVAADAMRALVAVVFQEHGLAGARTFVTNHFLHRQLNLAPLLKFNNPKLALASTCAKYNKPAPQSRMIAESGRLSISPVFVVGVYSGATKIGEASGSSIRMAEFRAAEDALRRLYLAETPLGDFDLPSVTLDASFPGLTPSAAQASYNPQPLGQAEVLPAAGKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMM6</accession>
    <name>W3VMM6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02562</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002359_0_1_1"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="800"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="958"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1302"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1335"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1407"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1447"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="13">
        <location>
            <begin position="724"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="748"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1513" mass="164043" checksum="0CE00D7F9CF1C9B1" modified="2014-03-19" version="1">MPSTPSASASPSETFRITAADIYTTSETGKAGMTLSSAKGRPAGRCHMKGNCGKKSIFSPELPCPVDEKATVPQDDDFRQLLVSTCGSDYASGPVCCTQAQVESLGANLQQAEPLISSCPACRNNFRSMFCAFTCSPNQSQFVDIVETQEVTGSDGRPSEAVKTVELFIESDWKQKFFDSCKDVKFGASNGFAMDLIGGGAKNPNAFLKFLGDEKPLLGSPFQIDFPDQHRAASSERFAEAYSSRRNDSLQTPIPFNVNPRQCSDPDLLSRCACVDCPDTCTALPELPGSNGDGSTCAVGAVSCLTFSVILLYVLLIGLMWFWRPLRRLLRGHGAIALPHRTSGHSFFAGSSGFERVRLDSEDSLSDLNDASPPNRSSGGNLVGARGLGHFGEESSSTSAPDGTYRGIGLERNDNLSALVALQPRKYALNQFLTRSFYKLGLFCASRPWLTFLAAAVFVGAANIGWKHFEVEVDPVRLWVAPGSTAKVQKDIFDKEFGPFYRPQQIFIMDSIAYQNLPMLRQSASSAELEKLPSALTWERLLWISDLEREVRALRSPSGVTLQDVCLAPAGPGTPCVVQSILGYFQDDPIGYGLEASNWDQALDQCASNPAECLPSFGQPLKTNIVLGGLPADAQPSQARSSVTTYVLNNSLDSKQVAAAEEWERELLDLLTRVAANPANSPKSEEAAAETHPLSVRRQDLGLQIAFSTGVSLETEIGSSSNTDVGIVVLSYLTMFIYVALSLGRQAPKLGGRADPEPSRPVAEPGSYPRMTSASLPNGTSQILRRIRQMIQSFCVSSKFTLGLFGILIVLCSVACAVGIFSALGVKVTLIIAEVIPFMLLAVGVDNIFLLCSEMDRQLEMQASEGSASAHLDSRASETLIPSMEPPQHPSLSLGDDFEAQEGARPTDSAHQITRLTIEERAARCLARVGPSILLSATTQIVAFLLGAMVPMPAVRNFALYAAGSMLIVAVMHCTVFIAAMALDAHRVEGGRVDCLPCLKAPHQQSHARTSDSTAATTSEAGLDHFIRYRFAPSLLRPWTKRLVVVAFGAIAVMSAIGIQRIEMGLDQRLALPSKSYLRPYFDAIDVFLDVGPPVYFVAADEEVSARQGQRALCGRFTTCEPLSLANTLEGERARAQVSWIAEPASSWIDDFLQWLNPILDGCCRVKISDPSVFCGPRDSPFSCQPCFEGRDPPWNITMDGFPEGEEFYRYLGKWLESPTDQECPLGGQAAYSSALSIAKDPVNGNESVRASHFRTYFSPLRSQSDFISALEQSQRISEDISSRTGYRVFPYSLFFIFFEQYTYLLSMAVQVLGSAAVAIFAINTVLLGSWRTGAVVTLSVASTVLLVAGVMGFWGIQFNALTLVNLSVCAAIGVEFCAHIARAFMRAPGSLPRSHPMAQKERDERAWLALTDVGGAVVNGIFSTKLIGVGVLIFTKSDLLKLYYAKTWLCLIVGGLLHGMILLPVLLSWLGGRGWSTGEDESDVKRRLNRAGSEYRPLMASEPDASDDEENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMS6</accession>
    <name>W3VMS6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMS6"/>
    <dbReference type="HOGENOM" id="CLU_282874_0_0_1"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="4">
        <location>
            <begin position="1120"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="828"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="930"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="845"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="953"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1006"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1186" mass="130761" checksum="DDDB7F5AC3FF8847" modified="2014-03-19" version="1">MAEPLLGVILATSSSRGDHVVFRWPNNPKIFKRYSKVKYYTESRPSGRPLPDDDLDPVRQKAKWDRHDEDDDDHAHSDDAGQSDTPSSSDIEDSDASLADDDENRSVRDRAETVASHGRCGPAAAPSTNRSKSKPRRPLVGLEESTPSVRSADRHNAKDTQDANDRAPDSDAGTSKELSPEEKARREEKAAMAYKTYLGYDIEILASILNPRPELAHQKFELIVDDLAFLGHPVAASKAGTWGEPDNHDGHPGATDSDDAHAAAPSQRRGRSGLRKEIRPYDVPDGHTPAKEHDADSAKKGKSEPKTSDTEAPASKAAAPLTQFHLVLVLDRPDPSTAMSGMDLSSWLQLFYDNIVFKMTAALFAEQSKSDYVGRETEKLLALRERCMDDGQAYSAYAAQCLGVSSLARCIRDLHKSISTSSDAFLTINDRIEVHLQLPPILQDPVNLPKTVDIETELDPNDPIFLSGGGFAGLGKEGADEDGGGGTYDRLLELAPHQLSFEEWCRTTGPYLLPWKTLLLLHDQPDEAARGRRTPGSASPAGHLTPAEQAPETHGFEQLARNFTSLFRPDLMHSLNFSEVADMLGWDLYEDVYPMVRHLIYYRQARVIDIPRPGHVYAISPLFDFGRLGALSRVWAHTFPELAPLPVFLSQLSSSSRALSALFPGRHQRELALEVLIWLLRRDVVVKMHIRLRLFATEAVKRRTAERGAERHERHRAQKQRKREKLARIEARRMKRSQAAEQQKRKKAEQAQRTETHDKHEHRGRSRERDRSRSVDARQQKQHDAAGDDLSAAASHMSVSRPSVLADPDSVAEAAALAAAIAGSDMHAALPPSGDADASHSQDHRHAHHHHHHHHRHRHGLVHKDAAGASETSGAGAGASGAIPIGSGAPLDELKFERRPVLRSRSPSTAAPGLSVSFSTLSERGELIRRARADTSASSSSGGARARGDGLSMTPTASQQSRPTTPSILTGPRNVPAHVRDRSVSAVSSSAEGSMPRRARGLSGRKIARSRSPSRARMRVRGFGLGAEVEIDEENDDDTTSAIKVVEEPRRRISTASERPELPPPSETDHSSHCSCSSCDSSSASDLSLSSDSDSDSQYAPSRAVDEYTESLIVEPARASRRENDYIATMVADKDPATVKNFFRLLPYLNGKHSIDEIEYRVKMRRRDIRRLLAVFREYIITFMHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN81</accession>
    <name>W3VN81_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">PaG_02901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN81"/>
    <dbReference type="HOGENOM" id="CLU_099135_0_0_1"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="245" mass="26457" checksum="20FC130502782965" modified="2014-03-19" version="1">MLHRHLVVRRSELGLAVEGEVEPSKVPKSHLDDVDDSRVWTRLHWDRSLVMSSAGARRPRQITPTSPSPSPEPQSHTGANGAGATKTSQPATALPPAQAEASAAIEPADPTESVRAALETRVRAVVDLLYQLAVCSADVQEGSQHLVANKVNECIKALAELDATKDELHRAHLMVPQEVLEMLDAGKNPDTHTRNFIGRLASENQYSYGQHNAVSSYKDALDAALDQAFPELAGTNKPAEAQDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN84</accession>
    <name>W3VN84_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN84"/>
    <dbReference type="HOGENOM" id="CLU_026673_29_1_1"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="371" mass="40329" checksum="AD00FF388606F281" modified="2014-03-19" version="1">MVTNHQVLFNKEQPTGLPKPGVTTKPSSVELDIDNVPLNGGVLTRNIAVSLDPTMRNRMKGDIGYFTPAYEVGKPVTAIGIAEVVRSEVDSLAAGDVVFVWSLGIEEYTIHSADAAKMFRKFDAAHLNNGLSITTYLGAAGMAGMTAYMSIKEIIGDLKPGNKMFVSGAAGAVGQLVTQIAHQAGVKVIASAGSDEKCQFVRSLGADETINYKTEDLPAKLKAFAADTGIHYYYDNVGGDQLEAYINVAARYGIIVACGYISGYNVDKPEDVVYPKNLFNIVTKELKYQGFIVSSFIPKWLGQFMNEIPQMLAEGKIKNREDVTFGVYGAEDAFLRLFTGDNNGKVAVLIDTERAEKWNLGKQKQSAKIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN92</accession>
    <name>W3VN92_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN92"/>
    <dbReference type="HOGENOM" id="CLU_136349_0_0_1"/>
    <dbReference type="OrthoDB" id="10345962at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834385" evidence="1">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="166" mass="18009" checksum="3EE0CD88EF6FF1A4" modified="2014-03-19" version="1">MFFRTAALAAFALVCIAQTGRCDDSSTDSGFWKPTGAPSTTGLKVDSNQVMAYCFSNKPTEKVPFACFTLKGDIRQRMRSPQNLKGYISPGGETFVVLAQVGGQSFTTEVERVTLTDRDDQSNCLHVKLDGLPQGAAEDEMGQTFFPSYDRDACPGKPAIHLQDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNA2</accession>
    <name>W3VNA2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNA2"/>
    <dbReference type="HOGENOM" id="CLU_112567_1_1_1"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="78"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="213" mass="23119" checksum="946F52A8325870C8" modified="2014-03-19" version="1">MSVPRRTQSGPRCALFARTRQPKWCQRSKWIAEKDSPSACTATRAASTPTTICNRSNENKMANAHVQSALNRFFDASKFAVVGASKDATKFGNKVLKWYQAHELDVTPIHPKEAEIEGLASQPDVARFLDAAGTSADKIAISVVTPPKISLTVVQTGLQDQGISTFWLQPGAEDAELVKWVQAQPASIQERVIYGGPCILVSGRQLAADKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNB2</accession>
    <name>W3VNB2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNB2"/>
    <dbReference type="HOGENOM" id="CLU_036827_3_1_1"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="5">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="6">
        <location>
            <begin position="216"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="154"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62284" checksum="EB6949CC09E1C050" modified="2014-03-19" version="1">MLKELTDQAQGYLGNRKPFSAVTDWIDRLCTQRYAEEEYDGIPELVEAINLQSTGPTEASRALRKKLKYSNVHGQKRALIILKALVENCGQRFQTTFANDQLVDRIKIMSQDQLVDASVRKLLMRVLLSWHQQFKDDPSMKLVAGLYQQCGGGKKSEAQRKSEAAEAYRKLQEKQRIEAQIRSDRKAAEQLQKEEEKKSKLRGKKGVKRPAFNFEQEKPAMLQSLAISQQVATALVNALQHVNREKESVTENARVQDYLVKTKVERKKIIRYVQLVKDEEFLGSLISANDQIILALELYDRLSKPAELDSDDDEPLAAISGSGQSAEEKTAAKIRADDAEIEMVRKRIADARLNAPDSELEKLQTRQRVRIQRHNSRVGSMRSFDMSPQPTGDGPSGASRGGAMNDLIDLDFQEEQAGSYLHPPSHAGGARRGMMASEAAGSSTQRGALSDFSDYESEDSADEHAAQAPGRAKQLAAASSRPEGGSWSNLNDSEEEEWLRTTQNHRPNIGPGFSWDEDDEGDDDPFADPFADANNAAASGSGWGIERPQNQPRKEWGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNE4</accession>
    <name>W3VNE4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNE4"/>
    <dbReference type="HOGENOM" id="CLU_094004_3_2_1"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="139" mass="15617" checksum="805156C79160F922" modified="2014-03-19" version="1">MSSGVAVSQECLAQFQELKLGKKIKYIIYTLNAQNTEIVVAKTSTSSSYDDFLAELPPAECRYAIYDFEYEKGDEGKRNKICFFTWSPDDAKIKQKMVFASSKDALRKALVGISSEIQGTDFSEVSHETVLEKVSRSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNF7</accession>
    <name>W3VNF7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNF7"/>
    <dbReference type="HOGENOM" id="CLU_031040_10_2_1"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="8">
        <location>
            <begin position="89"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="258" mass="28935" checksum="D826479CE79B8497" modified="2014-03-19" version="1">MRSCNVSSSQPATIDTLARPLPSVRRLLLSAVFCCISVLAFPLMSRFFSLFTKSSQPLIQHLGPPTTPTALAAQEALKSSNAVMSAQETATVASGCFWGTEDIYRKAYGNGKGLLDAKVGFIGGHESSKNPSYEEVCTGRTGHAEATQIQYDPSKVSYAELIEFFYRTHDPTQLNQQGNDRGTQYRSAVFAHDQNQLDIAKKVTEEVQKKHFDPKGKKIVTQLEIRKKEDFFPADDYHQQYLINNPNGYHCSTHKYWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNJ1</accession>
    <name>W3VNJ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PaG_03394</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNJ1"/>
    <dbReference type="HOGENOM" id="CLU_267467_0_0_1"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="686"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="873"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="958"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="996"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1062"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="21">
        <location>
            <begin position="253"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="511"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="565"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1125"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1182"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1125"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETS62316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1233" mass="137989" checksum="191D1A5489B5B589" modified="2014-03-19" version="1">MRSRSIAPLVRSARTIRTTPAMAASTSALRSLCRASRPTNFTPGPRPLCDHTLLQPKPCTLVHRRALATHSTSTPPSFVIPVIDFSAFVRADATPADRERTSHELTHAFKSSGFAYLRNHGIPRDQIDATFAMSARFFELPIDKKDALAWKDPRSNRGYVAEGRERVTQATSAEEIAALRQQAPDYKESLEIGNDHDAVWKNEWPTESDVPRFKDTMLAFQTAAHELHLKVLQSIAIGLGLAPSFFDDKCNEEWHTLRLLHYPSVRADKLKVEGSARAGEHSDYGSITLLFQDGVGGLEAKNPHTGVYHAADPIEDTVVVNVGDLLARWSNDQLRSTLHRVKAPQAADPNAEFTPTRYSIAFFCNPNENQLIESLPVFGSDSQRKYEPIMTKDYIAKRLSETTGAKTLDRGPTWRRTPPARDDRHCQANDGSYRSHRSYDHLQQQTAAACDMDLNSPFADPDRPEPLPPPSSSLKSSIFEHSRIVHPSTSIHTSSARPRPDNIREESYHQDIAASSASVGQNTTIRSNTLRTSSQADAVEEQDDDDEQDPEDLLSDEEIGLLAGEARPSSSSLLPKSMSRSTRQPHSRSRTRTRTRTASSPSRSRASAVGGLSAKQKALWMWANVDNMDAFLQEVYAYYVGRGAICIALSRSLNLLTVAFVISFSTFLFGCIDYSAIRHDGQLGDVIVGHCVAGFSPLTTVVVLVLVTAFGWQVVQFALGLSRLAAMHRFYEQLLGIPDADVQSIAWHEVVNRISALREQHPNTSLSSADEMELGERTNASLRPPREQRLDAHDVANRLMRQENYLIALFNENILDLSVPGLRNRSPALTRSLEWNLNFCLLGFLFDANGQVRPQFVSERYRADLIEGLRRRFVFMAVVNAIFAPFIVVYLLVYSFFRYFEEYHQDPSNLGSRQYTQYARWKFREFNELPHLFRRRCHASYAPAHKYIDQFPKEKTAIVARFVAFVAGSFTAVLILASVIDPDLFLHFDITPQRNVLFYIGVFGAILAVARGMIPDEHLVFEPEAMLREVIQHTHYLPPDWKGRFHSAEVHREFGQLYMLKILIFVQEVLSVVTTPFVLWLSLPGCAPEVIDFFRKYTIHVDGVGHVCSFAVFNFARQPTASTMGGAAARGMRSGSNERRQQSKLRNGMREGKMEQSILGFKANHPDWDPVQASVVDVHAHDPHGAGRHTYGDGSGKAHPPPTAATAESRGAKVKDLLDHIYRGRGAAAGSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNV4</accession>
    <name>W3VNV4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNV4"/>
    <dbReference type="HOGENOM" id="CLU_144270_0_0_1"/>
    <dbReference type="OrthoDB" id="10271390at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834741" evidence="1">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="109" mass="12221" checksum="F60F4D7C09DF163C" modified="2014-03-19" version="1">MWRLGQFVAVAAIAACLVHLSSAAATPRLRRAIVGDANDERPLGRRWFIDWGGSLGRLPSRDDMITPIDPVNLEAHRAATESAWEAYRRRLAREQAEYWNVIFGGHTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNZ2</accession>
    <name>W3VNZ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNZ2"/>
    <dbReference type="HOGENOM" id="CLU_415672_0_0_1"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="497"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="675" mass="72201" checksum="C9C7B8163FA06EC9" modified="2014-03-19" version="1">MHPPPSSMAQNSTTLYQTITNTLGRTNTRSNSSSSSASNVSQSSQRSPPASSHKRTSSLHKSTSPSYSTSALPRTLVFDYVRPEEVRAAHALEVEGYPPEDAASYQRLLQRQEAAPHLYLGAFVPLPPPKVAGPLSVSGQPRRRIVGFITGTAAPALTLRSMSTHDTSEDAHMVCIHSVVVAPEFQRKGLATRMLENYISRIRKAEEGKGPEGVKGKRGYETLALLAHEELTGLYRKVGFRVQCVSHIQYGSGQWLEMRRSVYPSPGSGAGSRIGSALTRTTSATSSASDDNPVGLKMTANTPVTTTTSATNATDDTPTPTQTATDAKATSVTPKPSSPAPASPAGMPSQASIMAALAAQSQPGKSPGQTYTSILGQAVAAKTPAEDAGMALEARLVDRETGTNLAKLYCPMENCRCCILAKGAGEWTRKESGPLSNPALELPNSPSPPQAPAFPLHAASPGISNRLLTTVKGFWQVAGPLQFDNVGFSRDMKWTVPIGNDPTSPRLESADASAPSASSISAELNAPRTKAQEKEARDKQKREDKERQREEKERRKEQKAKEKQEKRDRKRGGSGSDSNAEDEDVSSLLAHLSLGLTPGEELTVKYLLCPDCECGPLGFTILPTEMQGGRLAAEVGDQVEQMKGGTLGAPGAAPKRPPQLFYLAADRVRYQFERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPC8</accession>
    <name>W3VPC8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPC8"/>
    <dbReference type="HOGENOM" id="CLU_014801_3_1_1"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="726" mass="79301" checksum="2AC12528A547C825" modified="2014-03-19" version="1">MAPTADVLPASEASTRPGLLVQPSDTKLRKASSFRTEQVVIDGNNLKIQGLVASARYGHIPILDNSPAVRKRIDDSVNSLIAKLDRGESIYGINTGFGGSADSRTANTRALQLALLQMQQCGVLPVPSTFPTGEPSSAPFALPLTDTETSLVMPEAWVRGAIVVRLSSLMRGHSGVRWEVLDKMQKLFLQNNVTPVVPVRSSISASGDLSPLSYVAGALAGQRGIYCWVTDKKSGQRVKVTADEACRMHGIEPVLYEPKEALGLLNGTAFSASVAGLATYEAEKLAQLTQLTTAMAVEALKGTDASFAPFIHEVARPHPGQIKSARYIRALLSGSKLAEHLENEKHVLFSEDNGTLRQDRYTLRTASQWVGPGLEDIENAKRSVDIEINSTTDNPMIDPYDADGRIHHGGNFQAMAMTNAVEKIRLALCAMGKMTFQQMTELVNPAMNRGLPANLASTPDLSLNFHAKGIDIALASVTSELMFLGNPVSTHVQSAEMANQAINSLALISGRQTLQAVECLSMIQAWSLYLLCQALDIRALQYKVAEQLPAMVLASINSHFGEWMDEAKQAEIALLVFKSMSKRLDETSSKDLRDRLVETYQDASSVLVKYFSELPSGGGADPLRNIVKWRAAGVAETEKIYRDVTVEFLDNPYACHASHLLGKTKRAYEFVRKTLGVPMHGKENLYEFKGEFSQWNTTGGYVSVIYASIRDGELYDMLAELEKEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPD7</accession>
    <name>W3VPD7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPD7"/>
    <dbReference type="HOGENOM" id="CLU_2085800_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="117" mass="12247" checksum="D1A7A84018B07022" modified="2014-03-19" version="1">MKSTGAPTDERGGCSLEETETAASASASQTHFDAGPGSIKQISALTFGFPSSVVASQQQHQQQRQRGRGIGIGIDSRLPALFSARSAAVVAIAIAATHKPRLQLQRVCLIPPPEEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPJ9</accession>
    <name>W3VPJ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen debranching enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPJ9"/>
    <dbReference type="HOGENOM" id="CLU_012888_0_0_1"/>
    <dbReference type="OrthoDB" id="2591256at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="95072" checksum="54A9D2719CC71F34" modified="2014-03-19" version="1">MKLPIVEPKAIAVGFVAAAMAAAQQSSSASMSRSASASATAPSSASSTAPTSSSAPSNPLITRTPPEQIDLSLNLTSGPYDNYFYRSNLTAAQVLLTNTSAANPSDNSTKPTLNRFLVALPAGNSGSVAYFLPYTNGSAANATNSTGSGLTVTLGESGIKGAFGDGGLHGVTGELVLSQSATLGTTLLGSIRTVRDYTEGNGLTNQIFNWTVTQADNQTIWLSKPWLNETIVRNAQGEQTGTARYSLEWLLQATNGTSFEVIPSNNGTYTPPTVHILTPPVNTNDTTRAMPQPATVTFTVQVNETALAPLSVDTLFASNTSASMQPEAQTQFSFLTYASKFTAGGWRFLTYFGRDTMFTTRMLMNNKTLTPFAIESVLGGVLERINITSGEVCHEETIGDYATFVNIGEGQPEKGNEPFYDYKMKDTHYALLPQLADYLLRYNATSSNLTASDEARQFLARPATLANGTAYSELLYANIEYVLNTSTAFANDPTNYTNLARIKQGTPVGSWRDSNPGIGWGTRSFDVSTALVPAALYAISDLATSGLLQNFTSKTANISQDNLAETARNYAQVWEEEAPKFFQYNVTSEDAESRLRGYVQRANLSDSLLYGQGSLNSTSASNATGNSTAESGMQRRWGGVSFGREAEFSLLSARQASGTNGTNTTQSEGGSGNQTTLYGLSLLEDGTVVPVQNSDLSFNLLYSRRPSRTLIEAVITALQPYPRGLLTNVGMLVTNPAYDPNTTKTEELDRTAYHGTVSWGFQTNFMASGLDRVLASCDNSTTRTEVEKSGLTERPEWCDDQQLVDRLTNAQAMLWQAVNGAYEERFAEVWSWTWSNETNRFSVTALGDISPEGTESDAIQLWSYGLLGIQDPTMASSNTSATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ49</accession>
    <name>W3VQ49_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ49"/>
    <dbReference type="HOGENOM" id="CLU_294956_0_0_1"/>
    <dbReference type="OrthoDB" id="2556318at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1082" mass="117639" checksum="B149ACB24098DEE3" modified="2014-03-19" version="1">MSYDTSTQSFNAVDQICPEPAFLPYSDFAAADKYLSERAKSEDHRYISCGGRIRHLSKVCRNGVQQADEVSAIVWKELRRCLHFDSPPRVLPRHLSITKDTDQTDQVNATSFLSLGQLLLAIAAGLGSPADEGNMAFEHPENDAFAGACGKRRSRDVLAGRDSWISVLDSASTLGTFAIDVLAASEVQPPKKTPQASEFPPPPPRPSVIPAHEACTKEATGAKTIPARPRKASARNNNVALPASEPERRQENGSRKELTAAHTGGRVTLEQTQRPALSPGLPNSYQNNGRTDPPLDADLAVTLEESQLRPALTVGLGSFGAPKAGEGTIKSRKSDVDQWRQPPRMVPSPALHIEMLKDVPWPRVTSPPFQTRPTTNAPAHSRTQSAQTTTTTSSHFSRGSSVTFPTTAPSSQESCINVAGSPAEKAQRGATGSRRGFGTVSGSISDTSLTNKLSGEFHKGEKEQHDGSRHIRAQSGSRSIVVTVEQSYSYQILEPVSKCEAIMLPRPRLRSRSMEARSAAVVTAIHAAPERVWHRDRRPSVGQAAFLTTRTAPIGTSGRVVHFSRSKSIAPPPSKPESDIRLKLHASMPPPVPPKDHLSMHASTKPLPPIPTPYPWKVTFSVDRERAESLELLEAAEILELNRQLDAERQAWRHQHSSSIGSHGSPFFDRLNPCLLDPSDAGVATTLTNRRVRRAKSDLRRPSEGSVKVERLWNPDGRDSTFLVAQPQQPNIYTSRRMSASSPALVQGQDERQVQRHGLLRQFATGLSTMVKRGNALERRSKMPDTGFTFPKHNDGGLGPKAASTSQLIGLHAFGKERRIIVEEPIVIGRSSVPVHAEAARIADGARAKAHADLTTQASSVACGRAVEGHLATKLQVCNANSQSGNDTHKKDLRRAEARDVWFDASQNINVTAQPALRTSAAIGALGSGHVEYSVSQEERDQLELDRAIAQLEAEDRATELDAPAASKTSCSTSECSCQMCRRSASKIARQAGQSDSATASWLNEPVQRLAPADRTLSSPYEEIKGDATRECGPSEHKLKRSDTENSNLSGDAHGEFRIWEANTVDVDSLFFRPPPKRTPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQB1</accession>
    <name>W3VQB1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQB1"/>
    <dbReference type="HOGENOM" id="CLU_1482609_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="182" mass="20438" checksum="767C0FC6A4B2B1C4" modified="2014-03-19" version="1">MERITDHFYSVYSPSMRCIVGTPIRGTGARHCHTLPETSARPRSQSQWVRHSKFARRARAALVTSKSKIELSWRVWDVFAEPSRPCCSSACARALDVSSDALDEGRMPEAARWKAPPDRSAQPLRIWAGVRVRMPVPPPPPPSSSALLSAPLLFPSAWSLIFEPFWIDRFSKRGDFEFGNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQF0</accession>
    <name>W3VQF0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQF0"/>
    <dbReference type="HOGENOM" id="CLU_811637_0_0_1"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834496" evidence="4">
        <location>
            <begin position="18"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="342" mass="36540" checksum="9FC56D9254818648" modified="2014-03-19" version="1">MKFSLALLALVPAVALAAPLEPRQGGVSVNCGGVSYTSTQVNRAINNGLSGKYSSSGYPHTYNNYEGFDFSDYCNGPYKEYPLKTSSTGYTGGSPGADRVVYDSNDGTFCGAITHTGASGNNFPELLAQDVDSKYPPSSVAGSVRGRQGDVALLTYDELDEKRATSFVADDGAGATVLFSGTTRNSFQGKTVSKLEYEAYSSLALRTLRDLLDQAHTSAPFADTPVARSANAAPESTQGANEDRISKCYIAHRLGEVRVGECSILIAVSSAHRKEAFVVAEWLLEEVKKNVAVWKCEFYESGETLTALDGQGTPINPSLPQRAETGDDQSWSWKANFPASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQS2</accession>
    <name>W3VQS2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02118</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQS2"/>
    <dbReference type="HOGENOM" id="CLU_033449_2_5_1"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000276">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="211"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="287"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="360" mass="38852" checksum="2D647B6B8D972681" modified="2014-03-19" version="1">MSSSSSSAAASGSQKKHKVAIVGSGNWGSAIARIAGHNTQRHSDIFEHEVQMYVFEEDYKGKPLSQVINETHENPKYLPGCQLPDNVVANPSPVDAVKDATMLVFVLPHQFIRSVCKQLKGKVDPNAHAISMIKGVEVKDGKISIFADVIQEALGISCSALSGANIANEVAQDKFSETTIGHRADAKGRENAELFFKLFDTPTFKVGIIEDVAGVSLCGALKNVVAIAAGFTDGLGWGDNAKAAVMRIGLMEMKRFSEEFFDGVKPETFTETSAGVADLITTCLGGRNRKCAEAFVKTGKPFDQLEKELLNGQKLQGTETAREVHELLAARGKVDDYPLFKAVYSIAYEGIDAHDLTSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQT7</accession>
    <name>W3VQT7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQT7"/>
    <dbReference type="HOGENOM" id="CLU_033975_0_1_1"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="497" mass="53404" checksum="D2C2BD16BD6007B6" modified="2014-03-19" version="1">MTTRASSWVRPALRAHSMRMAAPAPSRGLTMAAAAIAARQSSTAPQRLAAAIEQRTFVTSQPRRSSASATAEAEEPSIPPPLKGIRIVDLTRVLAGPYCTMLLADLGADVIKVEHPRGGDDTRAWLPPFAKPPTGKDALQPPPGKEDYWASLPPESAYFLSVNRSKRSITVDLKSPAGKKIIYDLVANADVVVENYLPGKLASMGLGYEDLKKIKPDIIYASLTGYGQTGSYRDKAGYDVIIAADAGMMHITGEADRPPVKIGVAMTDLTTGLYVHGAIMAALLGRAQTGKGVHIDASLFESQIASLANIASNYLIAGQEAGRHGDKHPSIVPYQTFQAKDGRIMLGAGNDGQFRFLSKLLGRPELATDERYATNAARVEHRDTLIPLLDQLLQAKTVQEWCDLINGKIPAAPIRNIRGTFDEHPQSKDRKVVAEVEHPRAGKIKIVAPAVRYGGGKMKITRPPPVLGQHTDEVLTQELGMSEAEVAELRNAGSIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQT9</accession>
    <name>W3VQT9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQT9"/>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150168" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="206"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="408" mass="44660" checksum="5883EFFCA4C37828" modified="2014-03-19" version="1">MKFTIPIAAVAVALSTSTLGASALPIHDVVSTGGFAGSLFGGLTSSLSDLFTPRLVQTAPEQQPYWTTEFGKQLLWYRGVHFMDLTDTPTLGELSAARLQAQGSNSLVGSDSKFPSKLQHHKALKKVFKLISQDGPRKHLAKFTSFHTRYYKSSTGRDSQAWLLKTVSELVASYDYVSVREFPHAWGQNSILLSVKGTNATLTKDRGVTILGAHQDSTNLFPFFAAPGADDDGSGTVTIIEALRVLLESKWRPETDVELHWYSAEEGGLLGSQAVAQSYERQATKVHAMLQQDMTAFVKQGTKETVGLVSDFVSAPLTKFIGSLVDEYLDIGYTETKLGYAGSDHASWTKIGADSAFAIEATFENSNLKRIHTTQDTFDHPEFSFDHLMQFVRLSASFVVELAGWSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQV9</accession>
    <name>W3VQV9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQV9"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_14_1"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="235"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="779" mass="84911" checksum="41FE28DB46B31ECA" modified="2014-03-19" version="1">MLRATAEVQADQSCLRAWTPTSSRAELSLMPKSFELPYIPCIAVGVLRHHIPAPSPSLPFELDVTGPEVAIPIPIETDEIEIEVDDAVGSARASSELDFAETHRKSEHLSEIRLESLPPSSVPNAQLQPIDELYSQLFPFTQQRPILGRQDQSRNDGHALLTPAGGHDSSLHGFDSSRHASEPPKQAHVDFDSSSLGPTRRPEETFSYNATPPLALIERRMARTLIGLTWGEIKLLSLAGAGFLVDAYDLFVINMIYPLLLLAYYPPGTRNIEWGLSGGVLKASASMGNVVGQLLFGFLGDFWGRSVLYGKELMLAMAATVLIISAPDSIHGKGVTIWMAVFRFVLGLGLGADYPLSASVVADRSSLKTRGLLLSLIFSNQGWGALFAALAALAVIGGYKSAIEAGDFAKLSGAWRILQGLPLAPAVIVLYFRLTLVESARFVQARYLQDHDDIATHASAAGLVLVHNAKGEEVAIQPTSVYTSTDAIKRANKRRKTSLTPSSLSSPLSSSGDSRYKLRRQIPSPRDLREAMRKAAAQSQGFAFRTIGVPRNDFWEYFGEWRHLRVLLGTSLSWFLVDITFYGINLNQSAIFALIGYTQGSAWHQIYKLALGNLIVVLAGFLPGYYITVALVEVVGRKKIQLFGFAANAVLFLALALTYTHIIHHAAPFFVVFVLLQLSFNAGSNATTFIVPAEVFPTRIRATAHGFCAAMGKLGSIVSSLGFSVLANDKRFGHTGIFWIFFGVSLLGLLVTVLLVPETKEYDADAVDRIELLERSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR87</accession>
    <name>W3VR87_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA protein C-terminal winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR87"/>
    <dbReference type="HOGENOM" id="CLU_021105_1_2_1"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="2">
        <location>
            <begin position="396"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="2">
        <location>
            <begin position="520"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="686" mass="76323" checksum="0D4D8B11BB6969B0" modified="2014-03-19" version="1">MVLIPRSAVSAAARPWTATAPLTTRAAAMAVAKPITAASIARPFSTSHRRTSEEPQRSSTSSSSGGRSEKDSSEGFRSFFNSTGWETAMGASVGVLLLGGAAMVYHSWYKRHVLKKMEAAFDPGYDPVLALAKSGDQLAHVRIEPPRPEDEMIRSIVSGKEAGRYFLVMGSKGSGKATSIIEAMAEIDADGCAFFDAHLDPTIVVDRFSESINFSNNRDYLGNLLGLSDLSGMSYYQQLERALHKLEKALITRKQKTGKPAIIVMNSAHLLPRDEEGTKLLHIFQQRAEKWASAGTATFVFTTADYWVYDVLRKASNRMDTLSFRDLSRRQSINVLRGCRKQYWGEKPSSQDPRVLQEVYEICGGRLGLLNKVARRKDMLRAARQLVEDDMQWVLSKTGIIEDHDDDVMDEQKWSTCSWLLFCELAHKQKELEDLLNDYGGRLPAFVNQDDVEDPQYSSLAAQLHSDAGWFKARASPVPGLTRFTTVAAAQSDDEKRPGSNQAGTGVRASVAVGADDDDEDDDDDEDDDEAATSHRRLTESPITDPSNDQESDVRGADVPNPHLTWGEARQVMTRPDFIMELDHLNVIHIDRHHHIRADSMPLLRAMRRVAESEGYGDRLESVMDRVSAIESLGRTRELVWKEQGDGGKFLIKKDHKGREFETWTLLGGDERLGRDVDGEGDDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRS1</accession>
    <name>W3VRS1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRS1"/>
    <dbReference type="HOGENOM" id="CLU_1897099_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="134" mass="14187" checksum="E6493B7DC9C111CD" modified="2014-03-19" version="1">MASRRTVACTPETLHLSASSDSAAPVTSGTSVLGTGFEARACGCQKWPPIRSQVRLAVIAHVEIGGDQKRSRLRFFRLGDVRYLRTLQVASPRVQPVAADAGLPGISAVPPGPTAAISGDASAYWRLRTHIDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRT8</accession>
    <name>W3VRT8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRT8"/>
    <dbReference type="HOGENOM" id="CLU_005965_0_3_1"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="556" mass="58056" checksum="FEEBE8C7D97A6491" modified="2014-03-19" version="1">MTEAAGAVIGINFGHSYSSIACINQHGRADVIANEDGERQLATRIAYNGDQVYLANQATPQLVRNAPNVIDNFVNLLGRPFYELTDAEKKRNSAPVIDSNGVPAFQVEIDGTQTVLTVHEVSVRFLRSLFLTAKDFLSGVPIAGAVLSVPQWFPQQQISALKAAAEEAGLIVLQGPGQLPAHPDGVEGAPYAPGKELDRNVVVVDMGGSSTDVALVAARAGLYSTLAYLHDATVGGATLDAALVAFFAKEFTKKTKVTIADTDKRAWAKLRNESEFTKRALSASNSATCSVESLAEGIDFTGTVNRMRFDMLAGPAFGKVVAAVEKVLAQAKVEACQVDEVVLAGGSARLSGLADRLAGLFGDAEEGGAHITASIDADQVIARGCAIQAQVIAAAPEGSKEAAFLTELPKAPVDSLAELKVQATSAPIGLVLADGAFVTLVPSNTAYPLRRSFRLPVAKGAESVAVTLDQGIDDVKVETIQPDPEDIDEDDDEPLEPETRKTAITKPAGKGLAAFTVTTPAKGAKSVLLTLEAAAPGKLSVSAREDGASSSVDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRV3</accession>
    <name>W3VRV3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRV3"/>
    <dbReference type="HOGENOM" id="CLU_549958_0_0_1"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="436"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="496" mass="53127" checksum="717FB0C9E9DADB69" modified="2014-03-19" version="1">MSTSEQASTSDTGTSERVLRLHVWGSHATLPTLDPTSLYAAALLHATFTHNEQVRIQLASASTSLARVPLLQVLDEHSETVQLIDSVDEIRSFCTSAGLDAAVAADAEKAAKQTALHALLDDQLLDLTLHSLFSLPSNYRTVTTPAYSAVGGVRPLTSSNPLAKLAALPAAFQPSIPARLRNVVEARLTAAGLWGLGGKEVAMQSSESDDLAARAGIVPTKKRGLGASAKQATRDEFERSKLINRARDVLDVVSAALPSSPALCMLDAPEPSSVDAHVLAYLAPLVFAQPKLPIDALPRLIESSYPTLAAYLATVRERLFPARATWVSPSDVQSSPPVLAGTQASSSLLSYFWPFDSSSKASDFAPPPTGTDTRSHARPTAPSSAPRPARPNGAPSQSPEDRRLRWGRALWICSALVGLVGYTFASGIVSVQFVDSDSLDDDDDDYDEEEEEGEDDEDEDDEGDDDGGWQVQGEDDEDDELDELDLEGDDDDDDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSB9</accession>
    <name>W3VSB9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005956_0_0_1"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1300" mass="140735" checksum="0D11D39176877063" modified="2014-03-19" version="1">MAMPPPPASIPVTIILSSTSSSFLLSFAWFLFRVGLLLLWWDSSPSLERAHPPFRPHHPPLRRLARGSSQPRSHSVSEDSVIPPRPVQPSLVRDATPGPALTASHASAWLQHRQHRCSTRLIRRLGCIDVDTKPQDAFIVLLSSHGPHQPPLPFLDPIGFHRFLGQLDDNVSYLSFSASPSSSSSFDQSPKHPSRSSSSACTDLGITGPRRIASGPIKSAHPGSLASVCAPAFAVGMAFYPDAQPVMGAYHHGPEAGFGMGLYPHHDPQQSANIPTVYPFVDAAGQTHIYHSHSYAHGSAAPGHPDHGVWQAPQAPRLSAAAARAGRQPTWGYAVPAYAPAHAATAWYAQALALPHPSQQPRTHQQLEHQLLVQHHMAKAHERQNGAPLYPSAFAQNGYQGHHHQHPPQYSHAHHSHHYPNDPHHSRLPSNQYQQRYPHHAHGVDASAAHDRYADRRQRDSWNTDAYHRDGRASDYAGRDWSDWHNTASSHRGSVPHLPHPGQAYGDHAYGPAVHRNSDDASLGAQHAWPAHHDAHGAAPAHGWDRAPHYARYASSMAHEAYHRSDASSRDFPSFEGGHRFYPSQPFDREERPRDAFASSRSGDAHAWQPSMREEPQHFAPDETRGHGEEGRWPGQTRQTHDVAAPTAAADQEGVPAEGASDAAAGPPPSSPDSLDKSALPIAAIGAQLIWNACTALFDPDLLAEAHETSDEAMDEDDEEVMSPEAESMPSSSSTPSLNTPDMSPWSSTVLDRPAEAPSSGDWNAFRSPFGPDRMPQLRPQAHSFTFGSDAASSHDDLHRMAVGAERARSALAKEAASAKRSRQGSGHSDALTRHSSGASTASSSEPGTPASLVLESPALSSTISAHSVETARSPLHVGLGMSLDRSRSESAIRSRRSSSKASTKAPCSKWSGRMRDNVVAVLRLVSPDWRWSNNDHLFVSLSESLSAASAEAASSRSPNSQSHGRPGRDSVASIVTSYANEPSPAFRRFVHQVLAQTLLSPTAFLLGILNALRLLIMAQLPDGSIDPVVLGLFAQPTSAAPFKLFTLGMMIANKHLDDNTFLNKTWNEVTGIPLAELNQTEAWFLKKCNYEVTVPDETWIGFLHRLQTWEEKRSSRGKHRDHESSQRLLLVLDEALGYFDAIPALRLDGDITLDAETPHKARAASPVDMWAKSHHRAASLAVLEGGEQHCRSAPAAATYTSQRSQAQEQGQGLARASHVSRASLAMENPSALLMRSSSDYLGTGGAFKEMDGVDGESGKLANGTMSGPLMPSALLAGSRSLFQHSGVFGALSTSGWAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSH1</accession>
    <name>W3VSH1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">PaG_00922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSH1"/>
    <dbReference type="HOGENOM" id="CLU_035060_2_1_1"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="166"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="356" mass="38606" checksum="2E1E4EC1782DBED6" modified="2014-03-19" version="1">MGKASTSTRGGKGARGGGSGRGRGRGGGGRGGGRSLADRYASALDNDSWRPDSAIDEPQRKGTRSSSDGSEESNSDEDEDSEADSDDEEATKSESESESGSDNEGSSSDADSDYNSVDGGSDVESIEVPVAMWDFNHCDPKRCSGKKLSRLGLIQELRVGQKFRGIVLTPNATQTLSPADAHIVAENGVAVVECSWARLDEVPFGKLKSPHERLLPHMIATNPVNYGKPMKLNCVEALAAAFYVCSMPAQGRLLLSKFGWGEHFPKINARWIRAYRGCADAREVNELSRKMVEEDRAEKEELKKRFDESGGIQGTLDRIADEADHLDSDEEREAEERALQQDFSKIVRITDSSAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSY4</accession>
    <name>W3VSY4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_02227</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSY4"/>
    <dbReference type="HOGENOM" id="CLU_040729_12_3_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS63902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="203" mass="23064" checksum="E3616C54D5A08B23" modified="2014-03-19" version="1">MGLLTIIRKTKLRSHEFRFLFLGLDNAGKTTILKKLQNKPQDEIEAISPTLGFSIQTFQYGNYHLNVWDIGGQKSLRPYWKNYFEKTDAIIWVVDSSDTARLTDCKLELDNLLKEERLHGATILIFANKQDIPGALSAEQIKKHLELDNVSSHSWRIQPCSAYTGDHLVDGLDWTVKDVADRIYYHGDADFDQPPITASLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSZ7</accession>
    <name>W3VSZ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSZ7"/>
    <dbReference type="HOGENOM" id="CLU_032087_3_2_1"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="279"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="497" mass="55280" checksum="8BF636942A5F9F60" modified="2014-03-19" version="1">MALPLGTSVAQAQEQGDFMIKPENSGPKLNTADWPLLLKNYDQLLVRSSHFTPIPHGCSPLKRDLQSYVKSGVINLDKPSNPSSHEVVSWLRRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVAVLRLHDKLEDPKKLPRAIETLTGSLFQRPPLISAVKRQLRIRTIYESKLIEFDNDRHLAVFWVSCEAGTYIRTLCVHLGLLLGVGGHMQELRRVRSGALSENDSIVTMHDVLDAQWLYDNQRDETYLRRVIRPLESLLTGYKRIVVKDSAVNAVCYGAKLMIPGLLRYEKDIEVHEEVVLMTTKGEAIALAVAQMSTVDLSTCDHGVVAKVKRCIMERDTYPRRWGLGPKAQEKKAMIKTGKLDKHGKAINGVTPDKWQKDYVDYSDAAAAPAAAAAASDVEKVAAAAVVEPVTPAKKDDESKKRKLEETPGAAIDGETEEERKKRKKEKKERKAAEAAAAGETPKSEKKKKDKKDKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT24</accession>
    <name>W3VT24_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT24"/>
    <dbReference type="HOGENOM" id="CLU_313124_0_0_1"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="951" mass="100542" checksum="0D918D5C265CC50B" modified="2014-03-19" version="1">MTRTGIQSRIDSTRLDSTLSRNAPPQESQFVVYLGLTTCRVRAQTNCDFAVQHAILHLLLLHRHHHHHPNTCTHGLPGSGSVSTTLLPAKATTTMASPAQVLADLLSKARLSLHIPASPTSSKSLVYFDEILNVEIVLSFPTDPLLPPARTASSHQLPLPSLPSPSQPHSDDIPAYLGALLACLHVNLATDYVPESSSESAIAQSKSTNPYEPLSTVQLGFEHLQLLPSHATHSNPASAAHAAVRAFSISWAGNQPPQPHRTLRDSPDSSTTASHRAHLDHDTRNWNVHWHCRVPVNFVATPFAPLLAVTAALTLRLDGAILEHHLPANTSRKFVRAGFSHSLLAPLHEGPVYPDESPTQSQARATASAALGLDGPNGLGSFLAHLPKETVGGNNSVVTPRSGAAALSSIHQRRNQALSPVLADAQQSSTRADGNGDLAALSAGTQIGSAAARHAGQAGAQDKAGLHIYKRSTRAILPLKTGLNVRMRTLLTQHNPGLGRRHRDAEEMQSSRLVLCVELENPLESPSEFVVNDILIKIEQHSQAGKVSATPLHALASVLPIHLDPGSQHNLLFYVAADPKSNALEGVVSKMATRNVNITISGRPSGTNDDFDSQWNCNLELSSVLADTAKVAGIANAARPARERPSQVGQVAGTPQYSASALRDTHTGGGGRSISMQSGVLAEMRTPRPGQLGMGFPSRSAQRHFSTASIGASPSQSTPAPVGFLDKAKQRAANRNSIIATRPEPVVKPWTTMSSTDAQADGLVVLSSIRRPQINAHGQVSFHSSLGHDGVARPSIATGAKAVDQNRLQFQSGDTAMLQLALLSKATASISNITLTWVARPNPSSESKRDSMDKGRLMDADSARLKSALLSARADASNGLVPVQTHVDLQASIGPGQTANTTLALTCLSPGYHVLPPLKLAYTITTPAGADANHSVLLDGLGSVHVVPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT96</accession>
    <name>W3VT96_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT96"/>
    <dbReference type="HOGENOM" id="CLU_125614_0_0_1"/>
    <dbReference type="OrthoDB" id="2555525at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834854" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19363" checksum="E0FDEF6A9EA636A9" modified="2014-03-19" version="1">MMFKSLLAVALVAVSMTAVRAGEVEITVDTHDNTTGEKPKNASIACRIESRSCKSVSHYTDLEYEHNMQVSQCYEPHTIKNWYNRLTPFGHRGMFVDTVYVSCPVPSICKDNKDSKACDFSTNFHDVKPKDVRQLLEDRINEETNCDPRIECYKIEDVDDQCFPKNKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTA6</accession>
    <name>W3VTA6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTA6"/>
    <dbReference type="HOGENOM" id="CLU_028824_0_0_1"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="551" mass="57807" checksum="F6B64071B4A8EDE7" modified="2014-03-19" version="1">MSGLLAFVLLVTGMGVGTLICGLIPLSLPLSHRMMRILEVFGAGLLVGAAVTVVIPEGANALFAHVTPASQPAVASAARAPVLATSLQPAYHPVGASPSVEQHQGESWAWSFITKRDEPPTGDHDHDHDHDHDKDSHGADKNTFTAADAGHRLGSSILFGIVLMYVIDQFTSGSGSSTETHDGSSHTHGGHHHHDYTATPQRPRLEAHRLSKSFHHKTEGGGAAARPLHKMSSKASFAIFDRADHGVAEDDEEARIGSASAPDASAHDEAHRRVDSIVTTSSSSDTDLPEDYDHHDASLYPNADFKRFNGSSTNVADLESPSAGAPLLRRQDTATSVASGPRPRSRRSRSVSSVRSVHTSFGQALTTIVGLLIHATADGIAMGASAQSGDSTLTMVVFIAIMVHKAPAAFGLCAMLMAQRLSRTSIRKAVAVFALAAPVGALLTYALLALFFDVDVAAVPERVAAQAEGIDGKSIGTALAFSGGTFLFVAFHAVLELAGADADTVVRPGVAGDEEVQILGKYLRIVLLIAGACTPRFLQSLLTGLGAEHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTI2</accession>
    <name>W3VTI2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTI2"/>
    <dbReference type="HOGENOM" id="CLU_115052_0_0_1"/>
    <dbReference type="OrthoDB" id="2555952at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833283" evidence="1">
        <location>
            <begin position="17"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="175" mass="16940" checksum="58EE39DD3AC3CF4B" modified="2014-03-19" version="1">MKWMGALFMGVAGVYAQTAGVPGTINVGNGQTAATFPSGLGGLSTGTTAVFTPGAASSASVSPYYVATDAAQSSTLASLNTHYSQAISAATPTTGPPTGISTGVPGGFTGTNTVSILDGQITTIPNAATTYTGPRSTTASAAGASSNALANFDTKPVSAMAAVSFIAVAAAAYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTK7</accession>
    <name>W3VTK7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00406</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTK7"/>
    <dbReference type="HOGENOM" id="CLU_104368_2_0_1"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="152" mass="16833" checksum="45FB74F4CBD7E91C" modified="2014-03-19" version="1">MSLPYAADAETSLSPSELQVLKSQYETELAAGHVTTQTKFNYAWGLVKSKQRGDMSMGVGLLTEIYRSDPPRRRECLYYLSLGHYKMGNYDEARRFNTLLLEREPGNLQAQSLNQLIEKGVAREGYLGMALIGGAAAVASIAVAGLMRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTM0</accession>
    <name>W3VTM0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTM0"/>
    <dbReference type="HOGENOM" id="CLU_008279_7_2_1"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="335"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="799"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="853" mass="90359" checksum="2BDA867F86F17CEB" modified="2014-03-19" version="1">MAPSIAQAPHPAPLSAPSSSMPSQGSSSVKDTAYSQPSTSAWLSANHSSSSGPAPPSFGSPSSLHGHDASTPTTSSQPSQSTGLSFRQPGQPSPLARQRRAAQQSQPQPQTLDPYLQSLHQAHLSAAFRPPSPANAPALTLSYRCRPDPTQFPSFAVLLDTLPRIATRPRPRARQPAHLNTATTADSTPAPSSISTHPSSPLTSEHPDLAASSLTEATSITAADSNAATSTTTTSTPQLAASKVNAWGTPKSWAQTLGRNGPASNGPIGVSVNVSDSHDSSSAAASPARSPKTSSSAKKSSRKSAASAPKPALMSLERLLADAHTRFDAPVTHPRGLVNKGNFCFANAILQTLVYCAPFYNLFTLVGNEVPADFGNATPLMEAVIHFLREFLPADASHDLNDGPLPGQDASTAAAASEPFLPEFVYDAMRLNKRFDQMRRGHQEDAEEFLGFFLDTLHEELISAQRRSALKLAQSASGPNGLLAKMSEEEKKLNGVSDDDLRRLGVRINKDGSSADAIGLGLEAALDDDEIVEREVMRPVSPSEQGWMEVGQKGKTAYTRTTSTSESPITRIFGGKLRSVLKTPGAKDSVTLEPYQPLQLDIQPAHVQSIEDALLHLTEPEIIPGVWSPARAAQVDATKQVFVESLPPVLVLHLKRFIYDEIGGVQKSQKPLAYGTTLDIAPEVLSPAMRAQPRPRYRLFGIVYHHGRHASGGHYTVDVLRQDGHSWLHIDDTLFHPIPAEHVVRNAASANKDHGHDGLAYLLFYRRELPGEADASATPSPVVASAPAKAAVAVKPNGSHAAAAAAAKGKQAKGGAGAKLTNGHADSAASSPRTQHDSPKPAPARKTVPGWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTU3</accession>
    <name>W3VTU3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTU3"/>
    <dbReference type="HOGENOM" id="CLU_625554_0_0_1"/>
    <dbReference type="OrthoDB" id="2552985at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="437" mass="46822" checksum="D227547D52296A2C" modified="2014-03-19" version="1">MRALVFLPPARLAHFAHARPATIHPDVVPDSVDPAAASLDDWSVSEVDVPPGVPWQVLHPRLLDETRAEESRKRVRIDSPVVVIETPTRPVSIAPAVPDRLATETTEEEEGDTSKVVVGPDSDEDVSPDISLLHKVPAVRAGGNTASVDEGVRLASQSASSLQVRPPRPAYAPPPTCRFTFFRRTSCVSSTSVSAAQTTTHDASEAPPPEHEADVDHPAGGVKLVRTLPAMNAYEASFHPPSAGDGEGEASLGDSIVPPPTLHFTLAQITPLSSILSPLSLPRRDTPGAASSRINLLVVMRDMGDTARVRRLKTTTTRLELVVMDGTLTRAGVEKHLLKLVLWDHLTLTPLQPGDVVFVQNVSIQPPDPKPRLGPGFPRATVAHAAQSHNSSIQLCYRSNVTTPADAALNFDPAIAAFDAKSNRILQLVALWNHTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTZ9</accession>
    <name>W3VTZ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_00425</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bud neck</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003955_0_0_1"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="120"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="19">
        <location>
            <begin position="1425"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="498"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="670"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="801"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="894"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="982"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="894"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="983"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS64980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1540" mass="165013" checksum="A909FF2272962232" modified="2014-03-19" version="1">MSTQRPVIQAIPPFKGAPLQPTDAQNRRPTAAEAYVALANRKAGANVVSTRATGSENYRPSHHAGSSHHASQRQQPVPAVDRRQPQHAAPAPAAERPKPTSRLEREKKRHHNDPKNIGHWRLDKLIGQGASGRVRLAIHDQTGQRAAVKIIPRTLINASRMSLRDADVKANKMILGIEREIVIMKLIEHPNLLGLWDVYETSKDLFLIMEYVAGGELFDHLVAQGKLVPRDARAYFRQIIFGMDYCHRFNICHRDLKPENLLLDETKKIVKVADFGMAALQPTEKMLETSCGSPHYASPEIVSGKRYKGTASDIWSCGIILFALLCGRLPFDDPNIQQLLGKVRAGKFMMPEWLEPASKDLIWRMLEVDPEKRIKMADIMRHPWFTNNGKESSHNPVSTSLETLHMEQLTHDTIDLDILGNLKTLWFELSEDDIVKELLSPGPSWQKTFYTLLVAHRENHSADDEDDMDDDIVNEQIVTASAVPAHAMLASSGAAKTLEIARPRRTGEGPGATSAPSSPRLESFDMERRHSTPEKGSAYNTVPVRTTDVTPTKVASPHVRPANPSPRLRPSPLDSPATSLKAPFASPSKLQAPLPAQTARPSGSPRRESEGSYVLPQISLQTASPQRNERPNVDLQRRNTSPTKAAPASAPPSARIALANLYDAPASAHGAAASTSSSSSSSSAAAARSRANRGSGSEMMPPLALPGRASSRPVSPTKATFGAAAAAAPAAPQPAAQPVLQRPSTARAHTTHAAPSIQVPQVGDATMQKFFQEIADELASIRATGEKPDALQSKIEQLKKSMALQQQPAAPAAASSAPSTSGRAAGARGSEMNQFEDAEDDVSEGESMRSVSQASSHQQSYTPSTPMTPLSPAELIAPLSLTDKGSARTSIASTVASSNASARNSVRSARSATEASSSGGTSRPTSVFSNISTGSTGLGRKRSLLGLRRGGGDKQATQHDANTIRSIAYEQTAAPPALASIFAPPAGSSARPGAGSSSSSRAPKNLGLGLDMGAGGVGGGMGAISPPTTPVTAAVATLAPVSGGAAPGKKDSWFAGLFNWKPATFTLMSTDNFSETLNEVVRRLQSYGVRVAMDESSDVQHTTLRCSMSEYRESNGVMTAAKPLRFRVELNILPVGSVANSPAMGGGLGLSLHGGAVMGGGGLPSPALSTYSRGSSAGGVTFATSVLVVQEKGALSTFKLVHGRLRREWTLDLASAVDAELCRPTLACRAWFGGVLGGWDWILRSEKSEARRAGREESEWNAASALDLQRPPRWEISGQNLHFALWRNDTHPPTRGSPYFAHSQPTNSSTLLTFFLRPRHHHSILRGITMSYGTHRDVGDVQRREAQYNASVSAAAKGFGLGLAGAAPGAYLLNRSWPAFRALTPAIKLFFVSSIAIGTGVIRADKAGIQFDQDHYTDAGAAIQRRAQTREERQWAELSAGDKALTWAKENKFSVVAASWAASMGGIFAYIHTQPMTFAQKLVQARVWAQGITLASLVGMAAITQIPSAGDKIIRQNKEANAHSWREFVPQEPAQDTVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU62</accession>
    <name>W3VU62_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU62"/>
    <dbReference type="HOGENOM" id="CLU_050888_0_1_1"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="331" mass="38649" checksum="C70024E2D7A530ED" modified="2014-03-19" version="1">MQSDDVIWTIIGHEFCSYKIKSKTHSTFCRNEYNLTGLCNRQSCPLANSRYATVREREGIVYLYVKTAERAHSPKRQWERIKLSNNYSRALEQIDKELIYWPKFITHKAKQRLTKITQYLIKLRRIKLKEEEQPQLVSIKKKTERREDRREFKALKAARLEKSIEKELLERLKSGAYGDAPLNVNEDVWMQVLENRNKENKDLDLEDEESDEELEEDLEEMDRMMEEEFEDEEGVGDREFVSDDDEDDDEDDLEDLYDTDGNTIASDSDADDDDASSDDDQPTTGKKPKGPSTAPTKKGKKPPRAGKKGPQIEIEYEHETEPLTKEALANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU78</accession>
    <name>W3VU78_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00561</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU78"/>
    <dbReference type="HOGENOM" id="CLU_012173_2_1_1"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="14">
        <location>
            <begin position="130"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS65104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="549" mass="58165" checksum="F59FBF164142BC93" modified="2014-03-19" version="1">MVSSRSIKEHHESSPLLSRSSSSNHSSGYLSLPLNPSHPILASHESVDLEAMSKTQTRSKPMVLLGSAGLALLLICLCAFSTNADAASVARSLIGLEQNAGRLEPRATTSNYSYQRMLANIGGASSTAGGNQVPGVQSGAVIASPSTAGPNYFYSWVRDAALTMKVVISQSTLDRTLVQNYANAEKVHQQNAASSSSGQGEPKFNTDGSLFTGPWGRPQNDSPALRASALIAFAKRIGLTDPFVTGTLYKSDLSAGSVIKTDLEWVSHHWQDSSFDLWEEVQGAHFFTLAVQRRALVDGAKFATSMSDPGAATYYNQQAAAVKTKLQTFWDSGNGYIQAYQGVSGRSGLDCSVMLGALKGWDTTNATAAVDATEFGPASDKVLATHKKYVDSFRSLYAINNNAAAPNAVATGRYQEDVYDGNGTSQGNPWFICTLAAAEVLNTAVSVANARGSLAVTSTSLPFFRQFSSSAAAGTYASGSSQFTTLTSGMKAMANGFVNIVQSHTQSNGSMNEEFSRNTGYNTGARDLTWSYAAFVSNDLASQGKYLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU85</accession>
    <name>W3VU85_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU85"/>
    <dbReference type="HOGENOM" id="CLU_005281_0_2_1"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="441"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="789" mass="85926" checksum="9CA4515013A79A04" modified="2014-03-19" version="1">MTDGPSAADVGSSPLAKRQKLDDGPAVPSGAEAGAETRMTEARAGITAYVEPKLAGFQGIIKQRFTDFMVNEIDLTGQVCRLTSLDPPAGKYLQQLRPEDAPVRSAEEEKEAAEQAAKEQVKAAVQGGMWPEEADSKLATFFTDEAIAGLKEMWAKGRQSENMATGANATLVSAASITTRPLEDKEQRTQVHKLVRELFAGRLATDSCTVRPRGARAGDDDEDAMANGGGSAAATRIAVRWANRSDRRAGDGLPEEANNSPPYIHFLLHKTNRDHQEAMGMLAESLRLGGGGGARGRGRGRGGFGGRGGGRPPTKDLSVAGTKDKRAVTVQRVSLKRNRKTLDDVYRLVNGINADIAAGADANAKGKGKGRTVADAVSKRADRGLRIGHLEYASQPLKLGQLKGNEFTITLRNVRPSTGGEVDDAFLSGVRASMDVIRDQGFINYFGMQRFGTGAIPTHHIGILILKNDFKQAVELLMTPRAASGPDADDGDSADLLRAKQLYGEGELEKAYLAVPRHCVAEKHILDKMRSNRWNQGDWTGAFGNVPRTLRLMYVHAYQSYVWNRLVSERISRFGTQAVEGDVVFTDNTDDWDTQLTAHDAEDADEDDDDVRNAKPELATWQRPTKQLSGADLSSQSIYDVVLPLPGSSIELPEGWMSELYHTILSADGLTHAQLSASKIPEYQLRGSYRRMLVRPRAFEYNITQYTDPDIALTLTDEERCLGISTTTNADAAEAGQKFTALTLKFQLPSSSYATMLMREALKSDTASFKHRQLTQVSQDQHFKGSATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUE8</accession>
    <name>W3VUE8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUE8"/>
    <dbReference type="HOGENOM" id="CLU_2039033_0_0_1"/>
    <dbReference type="OrthoDB" id="2556314at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834581" evidence="1">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="121" mass="12962" checksum="DE028004DC4B1128" modified="2014-03-19" version="1">MNLVSAFVFLLLAWLGQSVVVRRQWDVPLVVVGNYQSGSNLQAGNDNVQTVANSVNVHGNNNAVSSNSVGTTAATSIIQPAAQEDSDDDGLEAEVEATIRHLQAALARSRSGHYNLHTHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUG2</accession>
    <name>W3VUG2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUG2"/>
    <dbReference type="HOGENOM" id="CLU_113367_0_0_1"/>
    <dbReference type="OrthoDB" id="2129288at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="161" mass="18416" checksum="F45371021CCE1F67" modified="2014-03-19" version="1">MPLHRIYTPQGFFTKDEKRALVDSIASMYIGLPAFLVITLFCPIDEDDFYIGTQNHSERASEQGKPFVRIVSQHLARTAEGKERRTRTIRSLEDRFRAVLEAKNCEWEIHIEEPAADLWRLSGHDYPAPGSQAESQWREANKAVQYQGPTMADHLAEKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUW6</accession>
    <name>W3VUW6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_01087</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUW6"/>
    <dbReference type="HOGENOM" id="CLU_022158_2_2_1"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="16">
        <location>
            <begin position="69"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS64617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="445" mass="48610" checksum="18EA82104D6348A6" modified="2014-03-19" version="1">MCDHSEPSAIQQVNGTAPDTHVAIDTSAPNTNGAANGANGALTADNGNVGSVQPFNTRYSDFLSNVSNFKIIESTLREGEQFANAFFDTETKIKIAKALDKFGVDCIELTSPAASEQSRKDCEAICKLGLKAKVITHIRCHMDDARIAVETGVDGVDVVMGTSKFLREFSHGKDMTYITKTAIEVIQFVKSKGIEIRFSTEDSFRSDLVDLLSIYQAVDKVGVNRVGIADTVGVANPRQVYDLVRTLRGVVGCDIECHFHNDTGCAIANAYTALEAGATHVDTSVLGIGERNGIPSLGGFIARMYTADREYVMSKYNLKALREVENLVAEAVQIQVPFNNYVTGYCAFTHKAGIHAKAILANPSTYEIIRPEDFGMSRYVSIGHRLTGWNAVKSRCEQLELNLTEDQVKEVTAKIKQLADVREQTMEDVDSILRNYARAIENGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVD6</accession>
    <name>W3VVD6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVD6"/>
    <dbReference type="HOGENOM" id="CLU_066882_1_1_1"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HIT" evidence="7">
        <location>
            <begin position="90"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="8">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="304" mass="33884" checksum="9C473F0DD92FDDF6" modified="2014-03-19" version="1">MPQAWNQALVRIASAKDPNALPTDDRVLFYDDRTITIYDKFAKAQYHFLVLPRIPFKLANGRDKGNPAQAPPALSAANGKLTLGSTSSNVVPASHLRNISALMTSPYVVEVLAAVREASDRVLDHIRDDMQRKHGVTWSIERAFHAVSSMEHLHLHVTSMDLVSDRLKHKKHYLSFVPTVDFAQRLDDVDKMVAEGRQALPKSERAYENLLKGPLTSHHTGQRFKFFSELKAHLESHWRHTVLAQGETGPETHAESTASKRAASIGAEEHSTSRRKVESHQPESTSGPNATESDTDEEPALPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVU3</accession>
    <name>W3VVU3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVU3"/>
    <dbReference type="HOGENOM" id="CLU_1705002_0_0_1"/>
    <dbReference type="OrthoDB" id="10280983at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834599" evidence="1">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="154" mass="17094" checksum="CE01EDAFEF1C428F" modified="2014-03-19" version="1">MKIILPLCALVVFAVTWVQAGFPPMPDSVASGGEEIRGLWEAASRGTFMNVLPPSMARIQDEWTNFLSTEGEDIINRETFRGNIFAAKFHGHGKFVKMANFALTKPYQYHPNTDAYKPQVAALLIETFASRPTPARKVQWGKDLRLGRPGSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWU5</accession>
    <name>W3VWU5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWU5"/>
    <dbReference type="HOGENOM" id="CLU_124043_0_0_1"/>
    <dbReference type="OrthoDB" id="2524788at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="188" mass="19875" checksum="6283AADFCCACE378" modified="2014-03-19" version="1">MSQQLKTQLEAAGMQEDSAYYVGRYTVQGLQYGCLLATPLYLLQAARGRGFSLRGLARYNWIVPVAGAGAGSIGGYAAASQLDHPSLAARTSGLRLDAQRVRQDDLHLIGSVLGALVLPAIFLRRTGLVNGLLGGAGLGGAAGLITHQVQKLSKSSDPVAEVQKKAENAFDDAKDEAKDAKNELQKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWZ4</accession>
    <name>W3VWZ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232571_0_0_1"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1481"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1803"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1655"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1883"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1934"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1671"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1947"/>
            <end position="1956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2011" mass="219376" checksum="6564EE2F91AA4DE6" modified="2014-03-19" version="1">MAPPQLQRPNPVHASEPPQQTPNNTATTAASTVQFPPPKQRCTKCQPILQHRPHSSASVPANHTADSSSLVTPACHATVRHYIGPLPVPASAARAIARAIVEDTSFHAPDVDHEQPEPNNVSATDFANAPHPQPAQHSHTFSDPFQAPAQAPQHSDQQGQQRPAAPSPPTSPSSRNKTPTPLPSTRPRVVARDPSSASVLSNTSFVSAKSLPRSALSDSEAAARRPLSASDGQVPSSHDAPASSSRPVSPSRRRLGLLTRKSNQSFPSFGNTSLPPPASILKPSTPNGAALPRLNSDSTDESISRHMQNVRSAENLRVAALRQQRRIGSEGSKSTASTIAPSPNNPPLALPILDLPLDQIEEAITPQLPAQASFDPPSPRPEDSASPPQFTSYDTERRAFNTSNDTTIIRKSDEIANPPAASALRNQPSFSSGSEAHPASDPAHTPAKLQPDDLLHPTWEQSNLAPNRQAGAGGHIEAGTALSFSSHDDQDTDAQQRPDKLLPGIGRGLPTKRSLTFSREPSSAHPPRQATGSHLPRAVDHPREYSRQTRISRASTAGTFNTVGTIATEGSFGATAGNNSTLARKFFAGGSFRRVSKRGSLRRKLGPVRTNSVRDTRETDSPSPVRTRKRVSPFAVRARKPARSTSYASMHRDYNRQASVSGTEASVGDLSASTPALGVLPGAVGTSAGGTKWVGASFQIGKRFWDILEARRDDLQRAQPCSCSKDGANDAAADETESPQAAQQRKKVEEHAAKVDHLKQSPDGVITLLAQEAQDISDDKASAVPDDHPQRSSTPPAQRPSQPSIPSVKPTAGTKTPRRKLSKDDSLASIQSLHPDAAAPLAIEARQGWSEIVSKMSSLTEEIGTGLKTRTAERRQASSESKKAKQKEKEQYSSGSKAITQSSSAEKTSDPNVKIVARSSSLADTDSSSAASKSAYVSLNNASTYNSSYAPRTSSLATEASPAMTRKEALSHPAPPASLEKNDPQLVHQLLRRKSDLGERPDLVPDAASDHAVVLRQTLTPQQLTPGEELADPSAIRLTEQDPFPVDATPNSEGSIRRTEPAGKQPLTAGAGESSGVERKKTVKFDTGSSRPALKGRFTASLFAGRAETESTPLSARAATAPGDAQPRPPEEVLSRPQPDTMQLPKLADGSDTFSESSGSESVILTRRSVLKKDRMLVKLAWTPHEDLPNDFDELQARKYPIRDEAWREFIVVFRMGKLELWTDPSLTSKIVGHGDRLKLRTTIPLSRGSTFLSLYSPIDRIFCLTYQPWKSISTHHGRKGIHLRRQGTDIVLFDCRARSAAADWMWELWRELGGHIPESLEVHVPSFGLKIKMPVPESMPVERTTPVGTPGSQSGAAKGGVLALSSIGDTQDGGEGFKLINRDNIVSMTWKLLSSIPQWHDLMVASQARGVRLDLAWRRGNELEWIVNERTVDNEPRHWAVLCGALLRDYKHPSILELRTAAHYPTTVETAPGQFLHEPPAVEGFLWRVKPVSGALTRLYFTTYDGHLYVCRTARAFPPDRHLAAKLQEAMDMRVPKTSGATQGRGGKPIAASNRGALARALSKVFGTHKAARRDEDVATLRQNVLEAISYPAETEEELQAQIAAYESFERRRQFEQIRGSDGFIDLKLIHTIKTIGKGPVRCPGQDDLRRPKRMAAKSLQEDVAAAQHDDEESDDDEEDELAGDIGGQEGLEVVDDANELRRARQIEITLTNGKRIRLEAFSASVAREWVERVAELVKYWRRRERVDAMELMYASGVDVGELRRELQGEKARRYDGVDEQKLSPILGSIWNWCAIEACRNIVRSGRLFHKKSSYGAFKARDYVLIAGRLLCFKLVRSVRTSRARQNNGIFHRRQDMVIHLRDAYVYSGKLSEDMLKNGRSEPAQAVSGLGGGGSNSGKRHRVPRVYADGMFSVDDDEDCTFVIRYRPERVNTPADPGVASAGKGSAEREEAGTPALDDKTHKYVAMRARSRMERDVWVRCIAYEIERIVRADAEREARLRNAGSVDHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX32</accession>
    <name>W3VX32_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inositol phospholipid biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX32"/>
    <dbReference type="HOGENOM" id="CLU_048143_1_0_1"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="345" mass="36947" checksum="1C6ABA2E9A15FA3A" modified="2014-03-19" version="1">MSRPSPQRRSALPLGLQRHHIVFVAYLSSIVLLGTAYSIAYGTHINNLRLSSGADSQFPSTLPGAAVAPSIQTGADGSTQLGPLPPTIALPPHHALNYWANRKNIVNRIFVKKAWLWTTAAWLAQLFFLRLAAATPRLKKEDARSGQATITSPVSISVLRYMVATGAWLLFANWFFGPPLAERILTATGAVCVPSSNAGLGKVEEMYCRTRTPLSSTSHPALFSGSGAAKSIRAAWRGGHDISGHTFIMVLSSLLLLEDIAPYLAALLADSALGKAVFGGEKVEQRAKAVMGEQKAKLAVAASVALVGLWSWMLLNTAIYFHTPQEKVSGLIVALAAWMVIPKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDJ5</accession>
    <name>W3VDJ5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDJ5"/>
    <dbReference type="HOGENOM" id="CLU_475764_0_0_1"/>
    <dbReference type="OrthoDB" id="3338589at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="573" mass="61859" checksum="6600E9EFEAAFBDF3" modified="2014-03-19" version="1">MDKSMANGGPPSYAPAYDSASASASPSTASDPTATISTPATAPAPAAQEASAAPTWSIFALTQAALELPHITTTRRILPPPPQPSPLPAFLLHCTLFASYDLHAPHPVPFRDVGCPATHARGEAGATAKSKVSQSVTRLRKRLGVQIPVAYLGSPGFNPCQLDAVSPRGGLAFLSHPQPRNGAEMTARSGNVGRYRKVSLFQAQAREMTHIVSRPLVERVVSAVYAGQGIYNRMAVFPAEAVLSYTRDAEQADEKQGWLAKLKAKAKSSDSKPDSAAQGAQTIAQVRSPDTARGNEAIKSVKAPMVFATLDLLAPPPRLLETGGPYPVEMNKASDSDLATSARLISEFDRGSDDERFSRFLFTPTEADDALFAQMLRALERRGAIWCEAGRLITPSSRNPNPRERARFLVKGVFPERFANRCRFYRARKFEPMPSDLSPHEVRKFGAPLIVHTVVERTGSEGIDINDYVQPQPTNAHTATRADDDDDMFDWEWDENDLAPRSGEGGLPDYTSAQKEQLKGYGIQSARARALVEAEADFFTGWSIGVTDEPFKNGGGKESMGTGSALWFAGGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDR0</accession>
    <name>W3VDR0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_06617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDR0"/>
    <dbReference type="HOGENOM" id="CLU_009710_9_0_1"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="121"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="648" mass="72496" checksum="CC43809A12F32113" modified="2014-03-19" version="1">MSLSLRTLCRRGPREVFGLPCQPRPLVHPLRCAPSCERLAPRHFTSTINARSAPDTAPSGSRLKPYYVTTPIFYVNADPHIGHLYSDVIADVLARYHGYMNSGYSAYDRNGRTVSADTEALQADIAQRSPVSPIFSTGTDEHGLKVQKVAEAAGEDPRALCDRISQRFRHLADAANVDFSTFIRTTDADHAVAVEHLWRTLRERGHIYQGSHEGWYAVSDEAFYPETQVRKVVVDGQEQMQSIETGAKVEWSQEVNYKFRLSAFQQPLIDWLRANPTAIQPAQRHAQVLQEIESGLADLSISRPRSRLSWGIPVPDDADHTIYVWVDALTNYLTVTGYPAWANDASKEASLVERSAWPADVHVVGKDILRFHAIYWPAMLLAAGLPLPKTIVAHSHWTMNRAKMSKSRGNVANPFEAIDMFGVDTLRFFLMRVGGNLGADSDYNPAVLVEYHRKYLQGQLGNLVSRISAPKIHAGLAESPRDEEGVLLRPSAEDVRAVLDEETYALCERLEEEIKQLPGKVDELMQSFELAKVLELILETAVARANEMVQRIEPWNAATPAAAVREAIILTTETLRIAALLLHPFMPTKMTQLLDALLIPHNLRTSSKYLVRQDANGRLVSHARWRDPAQPKVEPLFPKIQPDPTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEF8</accession>
    <name>W3VEF8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEF8"/>
    <dbReference type="HOGENOM" id="CLU_1288744_0_0_1"/>
    <dbReference type="OrthoDB" id="2549016at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834068" evidence="1">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="214" mass="23352" checksum="14D6C15128A29B36" modified="2014-03-19" version="1">MLLFAWFLVLAGSVLAGGGSSSSRGGGGASAMRAYTNLHRSLLEPIGLYNARPQIVAPVSPPFRGRNKVADMQNYLRNLYNHDAYIDPESGAGLERLRGNMMWILNHPNDPRIRDYQRGLVSVMEEASGHARQEMQNALHPVNVRAQHAVPIRALGTKVGSVTSVIQAGSNSNQLTSHLGQADQDRFANAFEVLFSEKQLLSAAERHATSIPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEN2</accession>
    <name>W3VEN2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tip elongation aberrant protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEN2"/>
    <dbReference type="HOGENOM" id="CLU_019536_1_0_1"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="100180" checksum="ACC0E9D34D3BC76B" modified="2014-03-19" version="1">MPTKPKATRGAGAHGQQRIVIFRQQQSAAGRRSERQMDPSRLKFTRRRSRTRLARPPHIPPTHLAPIDFSASISRSRSVSQCLELTSLAETLEHCLRSTDNPGASTDESQHAYRRSRLDLSYVPKADLASKLVAADPGSLHTTAPALSPAMNKNTQDGRDPTSVHVLGMNVSQSQPLVRNMSGTGDVTPPSGASTPHQQGDYAAARTYIPSHGFTASRLQNQSSFSTGTSQSPASSEAHEELASFSSRSASHNDASAAPLASAADSSMRRSYVTRGNRSLNHKDSFGGSYGLNAAPDLSAESADEASTPSVIEHSRLSHAQADGSISEGHHRNISLSRAAKHARNGAPLAFQTRQQSVGHNDAVAGLTDAMEVLGRSAADPVYDSSTSRISRSPSVADANPNQSLAAAANAASRFESSDLASHPNDTTFSASTAYPTASDRTERNYTSTSNTPLSTAPDRPSVQAEVPGLPQIGSSESRSVSAATQLPSHVDDPYHDGSVHRSRSNGELLQPGKTLGGSDLLSTSQKAEHKPQHIERRDQGARDKASQSTIRRPGSSRTRDTATTASSSNRLDATNPAGRSLKTTHRVLPQLPSAQGVRPAPPPAMYWSKAPVHGSVPRRSFRAHTANLCDEVLWLFGGCDNRGCFRDLWCFDTETMCWSKPKVTGDIPPARRAHSATMVNKRLFVFAGGDGPHYFNDLFVFDTVSLRWSKPEIGGNAPSPRRAHTCNYYEGQLIIFGGGNGVGALNDVHTLDVTDLSRLEWRKMECSGKVPIGRGYHTSNLVDGKLIVIGGSDGHMSFNDIHILRLDTQTWYQVKTEEIHNRLGHTATQVGSYLFIFGGHDSKTYTSELLTLNLVNLQWEPRKVCGKKPQGRGYHQAWLRDSRLFVHGGFDGKDIFDDLHFLDLAACAYLPQITSFSVELDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFK8</accession>
    <name>W3VFK8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cutinase</fullName>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05532</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFK8"/>
    <dbReference type="HOGENOM" id="CLU_790164_0_0_1"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833120" description="cutinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="171"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="292"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="351" mass="35257" checksum="42AF25B2B22CEB00" modified="2014-03-19" version="1">MRSKVLWILCSLVLGTLALPADKDQASNDDGGSQASKKDDGVAIKKRSPLMMPGMGGLGSMDDLGGLGGGGLGGLGGGGFGGGGLSALGGGLGGLGGGMPNLLSMANPSSSSASSGADSSPLSGLMGMGGLSGIGNLGSAGKFASSLSRTRDTTSPSPNDAPASTPSTPGCPPLYLIFARGTAELQGTFGIVGRPLCTGLQQAVPGTLCYDTVYTSDAEYMVSPGIGANTASQFIASIAAKCPTTKYALAGYSKGAMVVHRIHAKNVVAAVTFGDPLKMQAVQSTNDVKTFCNLGDPVCENGMMIMAHLTYSMQDIPLAVQFIVQAFKSSGPATRRKRNSRRKQASHGAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFT4</accession>
    <name>W3VFT4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFT4"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001204">
        <property type="entry name" value="Probable CMK1-Ca2+/calmodulin-dependent ser/thr protein kinase type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="416" mass="46393" checksum="FF3B16691183CF30" modified="2014-03-19" version="1">MPFHNPLAKQPDSYVKKKEYEFKKTLGEGTFGIVRSATWKAADPPIGVAVKVISKRILRGHDNIVKDEMNVLKGLDQPHVVKFLDWFESKDKYYLVFEEATGGELFERILARGRFTELDACRTIRAVLSAIQYLHHHNIVHRDIKPENILYRTKEEDANVVLVDFGIAAHMKDDNEVLTSVCGSFGYAAPEILAKKGHGKAVDMWSLGVITYTMLCGYTPFRSDDAQALAAETQRGKVEFHDRYWKNVSAEAKDFVKACLTVDPKKRLTADQGMAHAWLTEHKEETQGVHDISAGLRENYRKRWKSAIAAVRASTKFRTFAALASESRSEGLAAEASSGSTSTDPAPTDEPGKISPPTKRELYSEDEDEEADGNEWFDTEDGNAAPASSEAKNDDKQEGLAGKLESTLQNLHLSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFW2</accession>
    <name>W3VFW2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFW2"/>
    <dbReference type="HOGENOM" id="CLU_105960_0_0_1"/>
    <dbReference type="OrthoDB" id="2554414at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18976" checksum="9C9C6FC773375808" modified="2014-03-19" version="1">MQAPRMVRMVRQDRRQVNPAAFSGVTDQISNLGQSAGDKASKATSGLTRTQTSLVIVFCIIGSVAVVSALFWVCSYSRRKKRSREMKEKAELLKSSSSSSSMRLPQTTAAAPPKRASRSLNTYNDGWGESRVALNSSFVASTNERYGWDQSQTHLATPSLPRAPQQSHHYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFW8</accession>
    <name>W3VFW8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_06555</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFW8"/>
    <dbReference type="HOGENOM" id="CLU_006668_0_0_1"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000510">
        <property type="entry name" value="Phosphatidylinositol 3,5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="16">
        <location>
            <begin position="1044"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="1232"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="575"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="965"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="965"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS59631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1276" mass="136927" checksum="1FBF231864B524DB" modified="2014-03-19" version="1">MADTDPGSSNHDDVATAPSHDVWADVVTPPSPPARTPRDDANGGASASMHAPAHLRAVHTDHTSADNSGFPSAGLSTRISRKDSSFGSKPSTQRPAFSPYEAENLDLAWASSSQQPKRKPSSSTLSANASVFKPSRQAQETLQVSSFGNDFQDPLSSAYSSANQSHTAPASPAEQDDHQGDETIRNDDAPTERANGNTDAEEQRDVIQDQNAQTKSAELSATDQASDDDDDEENFVYPGTTDADDPEDQPTLPEANGAPSAASLPGPVQADTPSIDDEAATSSNPAVVTTETASAQQPPVDPAHPPTQAASIDYDKLAELCSRGSLPDLQAFFEATCSATEGSPATSMFALANDPNPSNGLVPLHFASREGQTDIIRWLITEAGAIVEMEDREGETTLHKAAMAGKLSATSLLLAQGANANAKDSDGWTALHNACSRGYLDLVRVLIDRGQAEVDAQGGRGAWTPLMNAASKGHLPVVRHLTAKYHADPFIRNAAGETAFDVAAATFEIYICEVLERYEADRWNAAKFTGTASTAPGQIIPGRGPYEPLALHTTLPVVLHENQRLDTRLQTLAMNGAKPRWSSSSAARAHKPDRRSPTSMPPGPLAPSRTRHSPMRQDDVALPSRKLPYKLRLRVRTSQAAARRRAAMAASQRGQSSQSTQEDEMASTPTPESVLHARHAGRAAASTAVDGAEQESSHFWLSEWQLDTTHPLVDVEQGWQYAQSFDALDDKWSSQPPPPLERLLEGRGLSASVTRALTGGAGLANAQADQEASASGWVRRRRWVRVMRRRLDIEFGDDLEACEGAASGASELSGDEDAAYGSGSQGLSTAAMMAAQEAAKLECSQLGPDADYVSRARALAGSSAAAGATPADAMGADRDELARRIARLYMAITELRAAFEDDDVERRSRAEELRKEFTLQLGQLREAAGLDDDDDDEGDDDDEFIYPNSYKDDGASVFTRMVNGETSGTLSRPAISQRQSSAASLMRSRTEPSEAGTSLAAARSADLAASRDFRVPTNEAPNKVALRQGPAMREQNLQPQWERDEEARDCRGCGRHFTFFLRKHHCRRCGRIFCDACSSKRAQLRLAEIVVDPSLPGMAASEVLAPTRICNSCHAELQLPPQLQNTRGAEAVMTASRTRAAGDPSSRSGAETQLDEGGFVSTLAPPSDVSSRASELTECPVCSTSLQQLGGSEEQEAHVRNCLENGGGGSMQGGRYLVYRLPENSPIVGKECSICMEDFVANSTIARLPCLCYFHRGCIDSWFKRGRDCPVHARSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFZ1</accession>
    <name>W3VFZ1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_05424</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 17">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFZ1"/>
    <dbReference type="HOGENOM" id="CLU_012062_7_0_1"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="14">
        <location>
            <begin position="38"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="286"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="451"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="534" mass="58836" checksum="BFCEEF9ABBA1AD06" modified="2014-03-19" version="1">MGHGKSDRPYLSAAEHSGVYGSHSASSGKTASLAAAFEPVAFDCCALSFQPWTLPVCSPDCGVAFELTNLIPFLRKYGVHPITGRAFELDDVVRLNFARNEQGRFHDPVSMREFGQHSHIVAIRQTANVFLYDTVLRLNIKPKYMRDLVTDQLFTKADIITVHDPNRPELRDARQMHHVKEELALTQQDKGIDTTQQINTAATGSAKKLLAKLGGSTGKEPKAAPKSTALSRNKAGGASTGMAAASFTSSSLTPRTAIERVELDDEQTMFAHVRRTKRKAYVRLTTNLGALNLELHCDVAPRTCYNFVQLCKQGGYDGVVFHRNIPGFMIQGGDPTGTGRGGSSIWGHDFVDEYGEAGALKHSSRGMLSMANRGPGTNGSQFFLTYRPVPHLDGKHTVFGQLVDGAKDATLAKMEAVPTSDGDRPIRKIRIETVLVSDDPFEVYTLKQKDAAKANDPTNPEYIARMERKRRREHDRTTWLGTELQGKDDKAKQILTAATTVGKYMPQTQTQHQSKDQPQASKKRRAGFGDFSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGE4</accession>
    <name>W3VGE4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGE4"/>
    <dbReference type="HOGENOM" id="CLU_069674_0_0_1"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="364" mass="38360" checksum="BE9EBEA9F4328EFC" modified="2014-03-19" version="1">MAGIGVATGAALIANGSSSSSIGSPASASASSSSRTITVGVLAIQGAFREHASHINRLNTLYPLETIRSTLVRTPEQLGECDALIIPGGESTAISLGCERIGLLEPLRKWVRAGRPVWGTCAGMIMLAREASGGKKGGQQLIGGVDVRVGRNGFGTQVDSFETGLEIHGLDKQSEPFNGVFIRAPVVDALLLPTDLERVPVDQPTLVKRVDPATLPEGVPAPLTTSDAVPLTPGEELPSTASEPPVPKLGNADQALRIVVAPPLYDTADPVQSAQKRPPIEILATLPQPVTPPKSPANQPVASTASQRDPRLDLPRRPEHDSQIVALRQGNILMTSFHPELTPDPRLHNLFVAKIVVPYKLAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGJ3</accession>
    <name>W3VGJ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1749-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGJ3"/>
    <dbReference type="HOGENOM" id="CLU_049633_0_0_1"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="37486" checksum="604D935CEEF1C665" modified="2014-03-19" version="1">MASQPPFPAPLTGSLQLYQKKPIALPYFDSDPDLPHSLVFIPGLTDTIGTIPYLPELATTIRKHGFSLVQPQMTCNLGGYGLCSLEGDAQEMAACVSHLRSTRSKRSGKVVLMGHSTGCQDIVAYLLSARRAASALTKIDAAVLQAPVSDREFFELTRSSAEEQVRADMDRELQHATQLHLSGKDAQLVPRKQTEGIALPTTPEDKPDEAVEGQPNTGNASAVLAPAMTAYRTWSLNARGGHDDFFSSDLDDQQITDTHPGARTVGRAIRNLAHGSPNTARLLALIGEKDEYLPDGAADVLLSRWTQLLHPTGAFHAMIVPDANHQASTPTATTHLLTTLDDLLQSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGQ4</accession>
    <name>W3VGQ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGQ4"/>
    <dbReference type="HOGENOM" id="CLU_007860_2_0_1"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="187"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1071" mass="116263" checksum="7CE2FB0B74D8926D" modified="2014-03-19" version="1">MNGTSDSPLAASRDRAANTATTPTPPDPHKAAAQDASPPPQPPAIDTDPAHLPSDDLLKRHPDTAIAEGTAAEIGAKQKEYQRKAKHLSLAKSPKPVPHARPGDSPSFQAVLKDFDRLLRSLPIPLHRLVPTIVARIICRVFRSQNIMASNIAFDIALFFWRIIINLFFREIRPRSAWRVPREGPVIFVAAPHHNQFLDPLLLASEVRRASGRRVAFLIAEKSIKRRFIGAAARIMQSIPVARAADSAKKGQGYISLHPSGDSLLLQGHGTAFKSQLQPKGQIMLPKACGHATVEVVEIISDTEVRIKKELKDARALDMLRGKVPQQDTSKHDKKSIKAAAKAMDKVDHDLSDGVGCKYSCLPFVDQTQMYAKVYEKLAEGGCLGIFPEGGSHDRTDLLPLKAGVVIMALGAMSANRDLNVRIVPVGLSYFHPHKFRSRAVVEFGSPIDVPRELVGLFDEGGEGKRKAVGEMMDIVYDGLKGVTLRAPDFETLMVVQAGRRLYRAPGQSLSLGQTVELNRKFIMGYLQFKDEPRVVKLRQEVLQYNKKLRYAGLRDHQVERATRAGWRSLGLLAYRLGLLGLWGGLALPGAVLNSPIIILAKIISHKKAKEALAASQVKVAGRDVLATWKVLVSLGVAPILYSFYAAMATVLAHKYELSPRTRALMPLYTLVVLPTMSYSALKFAEVGIDIYKSLPPLFVSLIPGNHKTILDLQQTRAKISADMHALIDELAPQVWDDFAENRMLPNAAAPPAPERDALVWKQKNASGGASNDALSHPLQWMDERLFGWGRRRRSSTRRSMTAEEIKNLRGSSVAREGGANESAIDERDEQRDEDDGEGSWGDASEGSSYTDSDAEDEGDYEAVFSMLNPQTLMNGLRGGVLSPGTPGSGGGRRSRTHSRSRSGSRGSVGGVGETFAEKRNRSNQDLRALMREGGAMSPTTTRATGILDGAGAGSRTGRTSALPASLATTSMSGNESGGATTRRNRTHSLSEDVHVAELKNAGPAAKKLPFTAASQAFEAQHTGSAKQAGVLPKLQDMKSAENTPPATPKHEAQKTLTPSTTATKSAEEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGX1</accession>
    <name>W3VGX1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pop1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGX1"/>
    <dbReference type="HOGENOM" id="CLU_010896_0_0_1"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="175"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="271"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="711"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="901"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="518"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="623"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121335" checksum="CFF5635AD680AC17" modified="2014-03-19" version="1">MALATAVNDAAGREPTGRSADVTVGKDLGQSQHLGDADSQQQRHDSLGWLWLKLAQGCLEEAHAWMGLSFALRHHAYWEGMSSKKRSAPPAEPGPSASQGMSTAQSGRDQQQAQNWKKRKQERAHTARFIETQTSKVASSASSSRNTSKSLTPVPTQLAAAAAGLPTSIELESLVSSRAFQIQSFLRSIKSAKSATTTRAWQLLPRHARRRAASHNLLRLPTRLRSKALAELRSSTTQARTRSDIRKRLPSYGVIRATLRRKKLAERASHPQRRWLETHLWHAKRFRMTTEKGKGKERDQGTEHNRWGFVLPETTMMKSHRASWRSALEFVTLHDTSYFSVFRLGVRQAQASTADGVSAALAEQLHQVLAKVGLAEAAELKPEDIAESHRVIDTVLVRPTSDSTSRTKSEKDTVAAALAPVRVVILSGTRQFERPSLDQSTTYIHSCKEALLIVHPAADIYVRRALKAASMTMVDENKNALFDLELPAPGVMQAYAFQLDSTPDPWLAAGGKDSSLSKLEKKRRRRAYQTGSAKSDEVGSSTKRPHETLLLDDKAERKRKHGFNIFELVGPRAASLLRSVLKCQDGAEGNADGLRLRQMLEKHSKTSQRDSPEMVQVRVSDPRLSYPPKLNPVATTQCSAGDPAKATGDADSHRDDLFWTGAQPPTFSKGEIDSRRALNAIPGARLQPDSRDDVVPVVVMRDRLAGKVDRYMLVVPRGWGTAFFLSLVATHQSGASSGARVLGQHQLRHQKLELAAQAQAAGEHAAASMLSYPHNWLGTRAYADSEIWAEAARYEQWSRRPKGKRAEFAFASHKDWVAFQQSKTAEEIEAKLALDRTGVARPYPFGGSHHWEWIVGNSQRLFAGGKEVENVLPWLVAQPDVDLTRVAGIEARLSASSLASAMVAVKLQAVRKGTVTALSSLMLAPTFEEHLHWVHHLDPVHHPALVRNRTAAAGDKMDKQYLKALVERRCKVMQLGGGAPAQSIKFKPISGVWREYTFAAMEPEEMHERSANWNNAVGTVLDGDYSLSNGRGFGVGALTLRAWMGLTEWQERMDKQRDGEAATTRRPRNAVETRNLLLVREPGSNVVRPVSATLVPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHC7</accession>
    <name>W3VHC7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHC7"/>
    <dbReference type="HOGENOM" id="CLU_093241_0_0_1"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36535:SF1">
        <property type="entry name" value="DUF1772 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36535">
        <property type="entry name" value="YALI0E30327P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="261" mass="27701" checksum="1F9037F56F56C46D" modified="2014-03-19" version="1">MLAPVTALVGLTCSGLASGLTLAYPLLINTHFIDQQGAMISPPAPWVANLSIAQRLTLWERAFKAGFVVPALSLVTAIALTTFALQSGRGGKASSSLPQRLSVRWETRKKLLLGSAALTGSLLVFTLVFIRPTNNKLMALRVAANNKEAINASQAEALLAHWTRLHNVRVVAAFSGFALALYSLSMLRVIAVIAEVDIGLWNDAILKICSGAAPASFSAVTMFRQAWSICSSCVDGYLSGSSCDQLPEDGNSRAERPQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHK2</accession>
    <name>W3VHK2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHK2"/>
    <dbReference type="HOGENOM" id="CLU_015320_1_1_1"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF7">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="204"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="394" mass="41108" checksum="8D907A711953B8CB" modified="2014-03-19" version="1">MEAELFRKCVRAMQQGYAAQELRELCRCSIASLFSAHAPLGAILEASWHLRLGKHHLSPDDHRFTTSIHPSSLSSTAPVSPSQMSFLDKFRDAAQKAGIQANAFAQQTGRAINEQAATARAGFSLPKECDRSAKILQAFLADPNHPDSALNSIPKAVLQQAKGLAVFSVIKAGFVWSGKIGSGVVIARLPDGSWSAPSCIGTGAVGFGLQIGADLTEFVIVMNSEEAVKAFAHAGNLTIGGSLSAAAGPIGTGGAINAAIRDPAPLFTYSRSKGLFAGISLEGTVLVERKETNKDFYGQPIPAVDLLTGKVPAPEAASAMYEVVEAAEMVDESGIPQQAYVPTADPAHHVPVAGYDLSDNASTTTASTAVEPTAAAPAANKPIFDADASEKRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHS1</accession>
    <name>W3VHS1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHS1"/>
    <dbReference type="HOGENOM" id="CLU_315483_0_0_1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="861" mass="95843" checksum="482E063DB21F14E0" modified="2014-03-19" version="1">MADQGQDDSKAAQLHQQEEASASSSTASTSRTPFQFAPVPARFRRHLEVSVPPPPPAGRPTHRSSRRSSLTGSASSDGEEDDDFDEGRLNRFRFSRGYSSGWPANPAGTVPSTPTTPMTPLTPMTPGMHRQGSTYGSEKRKSGLSGQPFVLSQQEAVVATAAVEVETEVELAEEGTDAPAQSQAEAKEEEGSQEEHVERASTDPCRRSSIPESLSSDSEPAHSNSQFTHTESGPDALQTRLRARPTELSGPTTTEVDPFSDSNEAPTDPFASPQDIQPVSDLDKDRDAEKIGMASQGGKMAFDQDKFPDYAPLVPSRVTAGRYGLMMAIGALNMGLVILFLFLAPAGASLVVMVALKSRDILSVVWQSLLFLLSVAAMPFRKKKPKVIHPPRKIVSLVPVYKESTQDVLDTVDSIIQDNPVRPQDFNIIAIMADGFDVEDDVIVQETICRVEDSPYFSWKIRESAFRLQFGYRMNHPIMIVRKVKNAGKKDSLIFAFDLFNSDNEATGHCNAEARAMVLDHIRRLYNQPDLEYFDFVFCTDADTKILAGSVNVLADRLMDEGEKTVGACGIVEADFHKPGRSLRTCGLWYYWDHFQGFQYTYGQWIRRRSESSWGRVTCMPGAITMLRTGSILGQASAEYRKHVQNGNLVNRQVQYQGTDRRLCWSIISRDKSVRTVLETRAACFTIPPQSLSHYLSQRRRWGSNAYFNAFVTLTQQNQHLVTRVWMALELTRSTLVFFRMYNFGHFVFNLVTRFSLIGVAPLLAITLLPQIWFLLFVVIPTPRYRPLLHHLLYGAVLNRLCSIVLTPTVYANVLLGFGDFRWGKSHTGANAANKTPDAADAMERGESRPCTPPKDQTEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHY7</accession>
    <name>W3VHY7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHY7"/>
    <dbReference type="HOGENOM" id="CLU_519886_0_0_1"/>
    <dbReference type="OrthoDB" id="2552594at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834194" description="Secreted protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="46414" checksum="F19E994B1AA6FA60" modified="2014-03-19" version="1">MKLSSSFAALSAAVVVALCIGQAHAETVNAPLGLSQVNDEGVPITPLTYLNLEPSSKELSDAAKKVTTPPPLPKHPKRLLNPADELKPYVGQLSSPGLSVRAELGHSLIPSLPILGNLDNEGDHRTDVAEPKKRLVGPLEVLKPGEGTQYLPENHQTLGQRTVHPLNRRADSPVDLSFFGKNLDELAPKLPAGKRASDTGLNLLGADVPLDKLPLPGLKRQADTGNAQDAERANDFLGSLLGGKRDTITPDNLNLDSVKPIVNQGAATVMPIVLNQVKSKASPAVQGIKAANGLCSAFGCQNAVQGALGGVTKELPLPQARALGDKDMFEHGLLGGNGEINGIPVRRADPLTDTVLGASDEARDAILGVKDQADNAAGAFVKNMYSKHGEVQTKRDLTLPGYALLPGTGPMAKQGAQELIDFLDLPVPGLKRMDKLRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VID2</accession>
    <name>W3VID2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear segregation protein Bfr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VID2"/>
    <dbReference type="HOGENOM" id="CLU_023943_0_0_1"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="56028" checksum="E93060CE3A88B3FF" modified="2014-03-19" version="1">MADTTAAKPAANGNGNTAATSAEKKTHDRPAGNPDAVEIAKLAGGKPDPAANTAELDKLAKDIDAVQKELNQVRSLLSGAGPSKDSPAGIRRAELRGELDQLRNQQAGSKGARGKTLEDLRTLQDSISKKIKDLQHAKSKTPYKSTADVDSRIQRLEQLVESGSMKLVEEKKALSEISQLKKNRKTVENFDQIQSQIDADRTKVDQLKSTLDSPEAKALNKRYDEIKAELDAIQAEQDKQAGSRGKLLDQRTQLSAKLDALYQSRRDRQAAFRAANDTFYAKLNQERERRIQKQRDERAAHEAEKRKEHEQQLREDAALPAFSKEIEDCDVLINYFSKGSSSAAEDAKKDDAASNAAKAIGGKALNLRQVNQDSMVPKGAVLRQKNEDEETYFAGNSAKARKPKGRSKRGTPLDLADENNSAGAPAAGGDKLNVPLGTLSALLALSIPPPANAADVGRVVENLKLKKQYFVSNQARVTRENIEKVEKMLAKSSIKDDDDAVAPAAPAPSAEAGQVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIM6</accession>
    <name>W3VIM6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIM6"/>
    <dbReference type="HOGENOM" id="CLU_019845_0_1_1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF11">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="408" mass="43889" checksum="480BEF2F369CD4E9" modified="2014-03-19" version="1">MSIGAAAKQSTIAVVGGSYVGMRLAQALLPVLPPSHRIVVVEANSHFHHLFTFPRFAVLHRGGEEKALVPYTHALDGAQNAAIVHAKALSVHADPTNPQRGLLKLDRNHEGADTIEFDYLAIATGTQLRRPWSLPSQHTEPAKAKAEAVQTLREYQDAVKAAQNIVIVGGGAVGVQVACDIAELYPGTKNVTVLHSRTQLMNKFHPDLHAVVADRFAQRGVHTHLGSRVVVPSSGFPSFSQGQTFDVELQNGDKVKADLVLMCTGQTPRSELLASYAPDAITSDGFINVQPTMQVSTTAPLARRMFALGDVANSGASKTVRAASGQIDVIKSNILALIQGNTQLQTFTPGPSGIHLSLGLYESIKFGNPATETEKPRNLGIERDLKLDMGIEGTWQKWNVPKGTPWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIN1</accession>
    <name>W3VIN1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cystinosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIN1"/>
    <dbReference type="HOGENOM" id="CLU_046327_0_0_1"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29339" checksum="787F77C3B5FDE425" modified="2014-03-19" version="1">MLDQFSLAVVALSRLLGWAYTLAWSLSFYPQVIHNHTARSTRGLSSDFVALNAVGHASYLAYNTLLLYYAPVRKAYRRTHDGRDNVVQFNDFAFSLHATLLALITLAQYLRYRKANQQISRAVKLALAAALTAAVFLAGAKRLKLVNWLHIVNAFSTLKLAVTLTKYIPQLKLNRDRKSTQGFAIQNVLLDLAGGSLSLAQLVLDAVVLQGSWSGVAGDWGKLGLGLLSCAFDAALMYQHYCLYPQHQSDPQQPSESDPLLPSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIT5</accession>
    <name>W3VIT5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244509_0_0_1"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1435"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1576"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1445"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1588"/>
            <end position="1599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1599" mass="174500" checksum="305E2DCF37D491AF" modified="2014-03-19" version="1">MPPLRGHDSTRKFHCEVQGCSASFVKRAHLRRHEMTHTQRRDFHCPGCNRAFSRNDSMSRHLRRKHPHLYRAHQNTSLDPSDVDHLHLPRLSTVVGLSTTVGNIASSSGTTLSSRPSPFEHHSNSPVQSRQDDHRSFGTQLTRPASTSDMYAHPGLLHTSQGLAAGHSRASAAPQLSESPSSAQADTFRPYHRPDFAVKGEHDAFELAGLPLGVSGDSEAMDRSDSTRRPTDAEAQMPRSDWAQYSETQAATSMPSRSGSLTAPHYRFPWERLDEEMPNAVPPGLGGWQTSGSGAAPNSGVAQDPSRRDCFRMPSSQAVFEQAALPPGIPSMTEESHFDPQGAPDLLQSEFFTYVMRPPGHEEYGAGFDTRAFASQASDRVRVEPSLNPYQSGSAGSYAGHDPQMSPQARSDAAVDDKFEVHLRSMCEAAPGVPPPSTGQLQQILTHLGLDLSGSQGPSSEAVRSNAPHAQGSVSESSLSAPPMIPSQDVARASWDPDRLAPIVPNVHLHPHSQATSSQNSFYLPSLTASQAEYLGPNATSHRRPLDRSISTTSFPFDSGSQDRAPLVRAPGFAGARDESVPEAAENSESETVQPRAGSASTTANFLKPHDSFSSRTATWDEEGGRKDAQADAAPRNQTHDPMSGAQCSGESEEMVQSPKHGREGDEVAGESSSHASLLLAEARRLLARASNARLRLSISSHGQADPEMEEATSSPNTQHRDSSASIATSITSGDLLQLVVDRFRAFAHLCHDFKQPSTALVDQLKSSVPEVIRDFIPVFHPQRMYSQRAHSTEENLAVLALASTLSGDAEIREEGYRLVCYLYGVVVLSYKHSMHLGGKSSPTLNCLMLIGKHGLRQSTPEFYLRFEESYGHILQDLARLETRQIRRDEAMDRLDVDQIKGMPNEELCSTWTRWYEHESRKRTLLLCAISDSQASSYFSPFNIDLAAHPESPRCQFLFAHVSEPCPGRVFFSWPPKAWAARLACSTSVPSSECADSTHRDGRPFSIAAHLADRLLRPHTAHATRPQLYPRFRTSFDFGPSNHASASFKAKPLLPNGEASATRSLNAMPAPIIEVDHASSVSNSSSRRESTSGGDAKEQDKRELRMVSQLYTLALLESIHGAWMSDTGWCQTAAWGASALPERLVIDEDDFDMASASMADLPGWRIGRTLKATQVVHALMNWSEIFSGWNDVSQADSDADDGAPRVELSLNDDAQQATIRWQAIFLGLCSPLPTLCFFLQDASRLDAKDRQRHGKISALLGKWVHSAQCRRALMHASTILTMLLATEQLSDHATIRPTTAHAAFMSLVVVVCAYKLLQVDASESSSASNVDDAQREELVPMRQVWPKVLMSLARSDGPTPAPACVDPIGRHKEGDDDWLWVSYWHRRFQHLGLAGIFREAEGGPGGYADWRASVSGPSNGGSFVARGAAHTRPRWSSFVGDGRWPTSTRDNTSGPAAEAFSSQRRASHAQPDPAHPDPDGDLLRRHFRRLSAVPNPIAETRRWVLAGSTHGATFCGLALSPAGKRVEGQGSESGEKRGEAVEHLSRDHLRELVARVQSAKLAWCFSHEFASLLHGALGPSSPGDGEQNHTSPPSETSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ01</accession>
    <name>W3VJ01_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ01"/>
    <dbReference type="HOGENOM" id="CLU_035339_0_1_1"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="426" mass="48046" checksum="B30D46EB502C31F2" modified="2014-03-19" version="1">MSAVTQHNLETPSKKVAAGLAGIDVNATPSKKPAAKLNLDDAADDDFSDPGFLTKGKKLDLASKTNAVADSADETAEAEDVHGKFVGEVDLPEEEEPLLVETSRRFVLFPIRFHEIWQMYKKAEASFWTAEEIDLSKDLHDWDNKLNDNERHFISHVLAFFAASDGIVNENLVERFSSEVQAAEARCFYGFQIMMENIHSETYSLLIDTYIREPEQRELLFDAVETIPVVKKKADWALRWISDRRATFAERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLFSHLKKRAHPDTVLKIITEAVEIEQKFLSEALPCSLIGMNAKLMCQYIEYVADRLLTQLGNAPHFNSTNPFDFMDNISLEGKTNFFEKKVAEYAKSGVARRETEEAGDGTQKNTHAFSLEEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ74</accession>
    <name>W3VJ74_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ74"/>
    <dbReference type="HOGENOM" id="CLU_144961_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="136" mass="15106" checksum="9F2F7F3864912FBD" modified="2014-03-19" version="1">MTEVTSKDSADVGSIESSVKDDKRDAAKAAEKQAAEDVADEDEDDEEDEDFEEGDEDDDEEGDYEEEDDDEVAAGDDDDDEEDAQDDDEEEAGDDDEEDEEDEEEEDDDAQTSNKRKADDDDDANDDDSKAPKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJF5</accession>
    <name>W3VJF5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_04151</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CWC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJF5"/>
    <dbReference type="HOGENOM" id="CLU_050460_1_1_1"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS61655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="343" mass="36875" checksum="2A76B21A148139AE" modified="2014-03-19" version="1">MDASTQSAASEPVVTFKRKRGPPSRAAPAATASPSTSSSSAAPGPSRASQAVLNTSSSDSDSDADSGDEVRSRSAVVTKKKRTNHNPLVQSTGAVRKQPRPDTAPDSEDDIYPSYSAAPASTAATSLQKIRDDATRHSNWDLDSSTPADAGESASNADGLYRGSKGYASYIAARDDGKSSKMRSRGPIRQTTTVRTTSLMDYQPDVCKDYKETGYCGFGDTCKFLHDRSDYLAGWQLDLPNSSSRAREDVLLSDPEEEDEEEVPFACLICRHAFSAPVVTKCGHYFCEACALARFAKTSKCFACGAQTGGLFNAATKVLERMNKAKAAKQQMKNSWRQLDVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJQ5</accession>
    <name>W3VJQ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Adrenoleukodystrophy protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_04985</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJQ5"/>
    <dbReference type="HOGENOM" id="CLU_007587_5_0_1"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000800">
        <property type="entry name" value="ATP-binding cassette sub-family D member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="274"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="623"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="841"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS61047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="891" mass="99413" checksum="B8B3EEDEB3E57118" modified="2014-03-19" version="1">MLWLLQDSAPRAASVGAAAAAHRSGSSSTSRGTSRAARQQSSRAAEQPAAPHAYKLPATALSLHHSTSIGTLALHRLPPDAPVNIVLVLVLVLITLPTYSTPRPLLAPFCQLLVHFTTPTGKHARRPISATMHVQSRLRPMMDELKMKGMTYGINFFMAYRRNHATIQRVLRVSYILFILHNLTRTLRAGSKKKPKKVAPPAGENEKAGAVASAQPAADVDDSSARGRGGRRGKKSRGPRVEVDAVFFERLKRILRIVVPGWRSKEAGLLMLHTLFLVLRTMLSLYVADLDGRIVSALVRSQTRQFITGILWWMAVAVPATYTNSMIEFLQSKLALSYRSRLTKRVHDAYLTDMTFYKLGNLDDRIKNADQLITVDVAKFSKSLAEIYSNFAKPILDVCLYNYQLMGRVGAEALIGINILVSGSATLLRKLTPPFGQYAATEQQLEGEFRFNHSRLIENAEEIALFRGQAAEQNVIERAYFSLIKHVNRVYRIRIIHGMTEEGIIKWLWGALGLCICAVPVFVRLPGGGKGLDLGSRTESFVTNRRLLLSSSDAFGRVMYSYKEISELAGYTARVSELLDTMDAIKAGKFEKKLVSSASIEENALVLQGRGSIQEDTSRTAGVEFRDVPIVSPNGDILVPKLSFHVQPGQHLLIIGPNGCGKSSLFRILGGLWPVYGGTVKKPPTSEFTYIPQRPYLSLGTLRDQIIYPHTAQEMRARGKTDEDLLDILRVLQIEHIVAREGGWDVQREWRDALSGGDKQRIAMARLFYHKPKYAILDECTSAVTLEIEKIMYDHATELGITMLTVSHRPSLWKYHSYVLQYDGQGGYVFTKLDAEKRLALQEEKQALEQKLLQVARWQERLDALKEARRERTHSRVGSPVQEKFAPLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK65</accession>
    <name>W3VK65_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK65"/>
    <dbReference type="HOGENOM" id="CLU_1402982_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="194" mass="20433" checksum="FE70252EE35B92D9" modified="2014-03-19" version="1">MVTTKEGRQRLSAIRRRCAQADEGSVGEFGSSAKIESPGSSASAGGRKSRVAELPRQCSVMWGSCVAGGQQTASYPPAIWIAWGGGQCEGSAWNPARQIVRNRSTSHASAAAIEDAHLTQEFPIFGACIARPPPNAHTTTDARWGPLLLATRSIAIHSRRSPRTLVMAETAASIPHSGTDALAPNLCIISDTSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-05-27" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKA4</accession>
    <accession>D4PHA8</accession>
    <name>LIPA_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase A</fullName>
            <shortName evidence="6">CalA</shortName>
            <ecNumber evidence="2 3">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">PaG_04054</name>
    </gene>
    <organism>
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Appl. Microbiol. Biotechnol." volume="72" first="931" last="938">
            <title>High yield expression of lipase A from Candida antarctica in the methylotrophic yeast Pichia pastoris and its purification and characterisation.</title>
            <authorList>
                <person name="Pfeffer J."/>
                <person name="Richter S."/>
                <person name="Nieveler J."/>
                <person name="Hansen C.E."/>
                <person name="Rhlid R.B."/>
                <person name="Schmid R.D."/>
                <person name="Rusnak M."/>
            </authorList>
            <dbReference type="PubMed" id="16575565"/>
            <dbReference type="DOI" id="10.1007/s00253-006-0400-z"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2007" name="ChemBioChem" volume="8" first="1409" last="1415">
            <title>Prediction of the Candida antarctica lipase A protein structure by comparative modeling and site-directed mutagenesis.</title>
            <authorList>
                <person name="Kasrayan A."/>
                <person name="Bocola M."/>
                <person name="Sandstroem A.G."/>
                <person name="Laven G."/>
                <person name="Baeckvall J.E."/>
            </authorList>
            <dbReference type="PubMed" id="17631665"/>
            <dbReference type="DOI" id="10.1002/cbic.200700179"/>
        </citation>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>MUTAGENESIS OF TYR-204; SER-205; SER-231; GLU-319; HIS-351; ASP-355 AND HIS-387</scope>
        <scope>ACTIVE SITE</scope>
        <source>
            <strain>ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2009-03" db="PDB data bank">
            <title>The crystal structure of lipase A from Candida antarctica.</title>
            <authorList>
                <person name="Brandt A.-M."/>
                <person name="Li X.-G."/>
                <person name="Nymalm-Rejstrom Y."/>
                <person name="Airenne T."/>
                <person name="Kanerva L.T."/>
                <person name="Salminen T.A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 32-462</scope>
        <scope>DISULFIDE BOND</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2008" name="J. Mol. Biol." volume="376" first="109" last="119">
            <title>X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation.</title>
            <authorList>
                <person name="Ericsson D.J."/>
                <person name="Kasrayan A."/>
                <person name="Johansson P."/>
                <person name="Bergfors T."/>
                <person name="Sandstrom A.G."/>
                <person name="Backvall J.E."/>
                <person name="Mowbray S.L."/>
            </authorList>
            <dbReference type="PubMed" id="18155238"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2007.10.079"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 32-462</scope>
        <scope>SUBUNIT</scope>
        <scope>DISULFIDE BOND</scope>
        <scope>ACTIVE SITE</scope>
        <source>
            <strain>ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes triglycerides, with a preference for substrates with short-chain lengths (C4 to C8). Has the highest activity with tributyrin (C4), followed by tricaproin (C6) and tricaprylin (C8). Can also hydrolyze vinylacetate (C2) and triolein (C18), but with lower efficiency. Has no activity with tripalmitin (C16).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">4483 uM for tributyrin</KM>
        </kinetics>
        <phDependence>
            <text evidence="2">Optimum pH is between 7-9.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="2">Optimum temperature is 40-70 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="biotechnology">
        <text evidence="7">In addition to their capacity to hydrolyze a wide variety of natural and non-natural substrates, lipases can also catalyze the formation of ester bonds between carboxylic acids and alcohols, making them attractive biocatalysts that can contribute to the synthesis of pharmaceuticals and other fine chemicals. Sold under the name lipase novozym 735.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="sequence caution" evidence="7">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ETS61940" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2 3"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61940.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="2VEO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A/B=22-462"/>
    </dbReference>
    <dbReference type="PDB" id="3GUU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/B=1-462"/>
    </dbReference>
    <dbReference type="PDBsum" id="2VEO"/>
    <dbReference type="PDBsum" id="3GUU"/>
    <dbReference type="AlphaFoldDB" id="W3VKA4"/>
    <dbReference type="SMR" id="W3VKA4"/>
    <dbReference type="ESTHER" id="canan-lipasA">
        <property type="family name" value="Fungal-Bact_LIP"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="EvolutionaryTrace" id="W3VKA4"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000433085" description="Lipase A">
        <location>
            <begin position="22"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4 5">
        <location>
            <begin position="122"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4 5">
        <location>
            <begin position="371"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces enzyme activity." evidence="3">
        <original>Y</original>
        <variation>A</variation>
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Abolishes enzyme activity." evidence="3">
        <original>S</original>
        <variation>A</variation>
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Reduces enzyme activity." evidence="3">
        <original>S</original>
        <variation>A</variation>
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Strongly reduces enzyme activity." evidence="3">
        <original>E</original>
        <variation>A</variation>
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Strongly reduces enzyme activity." evidence="3">
        <original>H</original>
        <variation>A</variation>
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Strongly reduces enzyme activity." evidence="3">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Strongly reduces enzyme activity." evidence="3">
        <original>H</original>
        <variation>A</variation>
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="41"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="57"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="107"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="124"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="157"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="163"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="198"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="239"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="267"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="295"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="307"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="316"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="322"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="333"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="345"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="356"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="376"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="387"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="423"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="430"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="436"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="453"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16575565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="17631665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18155238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source ref="4"/>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="18155238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="17631665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="18155238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="PDB" id="3GUU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="3GUU"/>
        </source>
    </evidence>
    <sequence length="462" mass="49265" checksum="700908D4C645981B" modified="2015-05-27" version="2" precursor="true">MRVSLRSITSLLAAATAAVLAAPATETLDRRAALPNPYDDPFYTTPSNIGTFAKGQVIQSRKVPTDIGNANNAASFQLQYRTTNTQNEAVADVATVWIPAKPASPPKIFSYQVYEDATALDCAPSYSYLTGLDQPNKVTAVLDTPIIIGWALQQGYYVVSSDHEGFKAAFIAGYEEGMAILDGIRALKNYQNLPSDSKVALEGYSGGAHATVWATSLADSYAPELNIVGASHGGTPVSAKDTFTFLNGGPFAGFALAGVSGLSLAHPDMESFIEARLNAKGQQTLKQIRGRGFCLPQVVLTYPFLNVFSLVNDTNLLNEAPIAGILKQETVVQAEASYTVSVPKFPRFIWHAIPDEIVPYQPAATYVKEQCAKGANINFSPYPIAEHLTAEIFGLVPSLWFIKQAFDGTTPKVICGTPIPAIAGITTPSADQVLGSDLANQLRSLNGKQSAFGKPFGPITPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKE0</accession>
    <name>W3VKE0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKE0"/>
    <dbReference type="HOGENOM" id="CLU_135723_1_2_1"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="103" mass="10961" checksum="ADEDD9F00B9F5E4A" modified="2014-03-19" version="1">MLQAALRVVSKPLRTAVTAQAQVRCCSSATSAAMLKAAMNTAARPATPALQQSAAIASTAAQQRGMKVRSSVKKFCDGCSVVRRKGRLYVICSKDPKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKG4</accession>
    <name>W3VKG4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-arabinitol 2-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKG4"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="48863" checksum="4DFA7A52FAD738D8" modified="2014-03-19" version="1">MQGWRPTHAEGAQASIGSPERLAIPTEICKGGNVRATVTATATATATLARLPGAPGTSRLDLCPPPNVGRPAKGEFARRPPWPRFNSPSIRAPVQPSLSNTRLPIMAAFNSALRSGAIRSLSARVAQPSMLSRAARAPAASAMKTFSVWAPARMGPTSANAADGVQANPGPPPPVENIGVDAVLRQNPNSPDNHTTTIFQEFSLEGKTAVITGGNGGLGLEMALAYVEAGAHVYAIDLPKEPSEEFKIVADHCRIMGKHLKYVSATVTDHDDINACMDFVMKDSGTDSLDVCVAAAGILQTYDALSYPADEFRKVFEVNTTGVFLTAQAAARKMHEQKHVSGSIILIASMSGSIVNRDHHWVAYNASKSAVLQMGRNLAAEWGPKDIRVNCISPGHIRTRMTAAYLDTNPHLLTKWSSSNPLGRLGRAHEIRGVAVWLASSASSFCNGSDIIVSGGHNIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKM5</accession>
    <name>W3VKM5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKM5"/>
    <dbReference type="HOGENOM" id="CLU_041799_1_0_1"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000006">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="4">
        <location>
            <begin position="132"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="400" mass="43871" checksum="1153896F8C700416" modified="2014-03-19" version="1">MTDSALFFGPSAWSERATLASLEPFLCIQLIALNHTSPPPSAGLLPEIECKQRHVGRIRRLAGRGLAAPRIRADKTSLFRPLRLLAVPFDPCRLPVLAAAAQIHTAVMAPKRKSQADVPTPNGSGNSSGRIAHWLMKAEPDTRLERGHDVAFSIDHLAACKTTKWDGVRNPEARTIMKEKMRTGDDVLFYHSNTKIPGVAGLARICSQSYPDPSAFDSNHPYYDPKSDKDSPKWWLVDVEFVEKLDTLVPLGLLQKIAGKGADNKPLTKEERNDVDYLSDAELEAIKGMALLNRGRLSVQPVEQRAYNAILALSRNRGWDHWPGKWNPRAAASAKPTPAAKTKPEQNGPLESAKTDRTAKAASVSSKPSASKKAKTEPNTEPDAAPPTDGLRRSSRRRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKQ2</accession>
    <name>W3VKQ2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKQ2"/>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000050">
        <property type="entry name" value="Related to XPT1-xanthine phosphoribosyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="254" mass="27964" checksum="5DCA4FFE5D1A1C93" modified="2014-03-19" version="1">MSLDQLPDDHFRPTYEEIHVQIGEAARRIKGEFDPDLMVAIGGGGFYPARVLRTFLKKPSALDPSKMRNIPIQAIGLSLYEEVSGTAEGQIGNEVVRTQWLDAKTVTGHKGPGKIEEGKDAGGLLGKNVLIVDEVDDSRTTLQYAYSELLKDVKNAIANLSAEERANLAPTRFAIFVVHNKEKAGGKRGTLPILPKQLAKGEDKIVEGVSEGVRYYSTQDIGDVWICYPWEEEDIVEHNRLAALAKKLGVNQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKQ8</accession>
    <name>W3VKQ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005395_0_0_1"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="888"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1401" mass="147073" checksum="AFC905AE0DBCE2C1" modified="2014-03-19" version="1">MPFTRAYSSQHNATMDPSTSTHASSSSHTPSSPRQADSSHIAYSSPDAPPEHDSSRSRLFSSGRKSPDPFRRFRRNSNNSLHILTAPPTLDAAQSFDAQQYHLERQDRSVPDYPAALNTPRSAPPPLPSPSTKPDFQRPKRTKSSSISILSSGLARRPKDSLPPSSSSPDVRRRHRKSASLSGSDVDFSSSNSILDSNHSRPTTPMMRPASPSPSLSDSLAFPPSSAAYRSKQHKQAWYQAQQKTIELEGTFNRGIHSPESSTAHLFPLNVTTTQSNSGPATDRARRSPTHSRSERPVVETFLSEEEMLAAGIHIIRRRDQDAAPTPPASHKHLPSLSTATLAPTKPPRLDGADQPDFLELIDSPIPSKHASPLLGQLVDPPASAAPLQRAISHTHAKSSSGSISMSSADSNDYLPLSSSRNQMHRDDSSSLNNGSASSLGSTGKHSFSFAKLRRNGAKNKDAASSSRPSTANSSNEEVNSVKSFLYPTRAAQPQPHQTHQSRQQTPVPTAPQSDAPAQAAASPPGYLSPGPSSSASPFLNKHSATVGRASGSSLAGHTAQDGLTQVFGGGSGAASLDPSSSAASARVLSSTNGIPPPKPPKPKPSLLAAFPRSDNATPGVSISAPTSANLDSRHPIDGASRNLLSLPGQAGAAQESAAISIYRNISHSRSQEAVAEARLDAEALRASAGTPMPPPRRLNQQRVGLAGAGAAGSPAYSAYSSSAMGRSTSGGAGGVVGALGHVGQFGAAMGRKGWDFMKTLQTSNTAATSGRNGTYASAYRAGGAGASSASSLAAAAENEPTRQWLLLLEAPESSRAASLRGPGEVFGASLQDAVLRSRLSSISTDNVRAEDHLGVPDLGQKFSANFLDSPGATPRASVASAGAGEPVDRDEARHLYLPRLVVRCIQSLERWGPSEEGIYRISGRSSHTAKLRAHFADPRNDLRLDEISPADLDINSVCSLLKSYLRELPETLIPPAHTAQMDAAVARLFAGIDSSAPAAEVQSAAAGKASEARAAQIPVEHVAKELTPLVQKLPVHNWYLLRELTHHLGLLAQTDVVAHTKMPLSNLTLVLAPTLSISLALLQVLVRHRDGVFGAAPHVDVASAAAQAASALAGASSKDSAPASPAKGVRPPRPVKPERLSGASKLPVMVRKRASSMGLGALLSSPTSKTADARDRVREQHRRTSSTTPSLELPADITASAASGARTPPPPSPRADEPYERPSTSLGHFDAAPARARPGHARYGSRDAALRFDALALDDRGDERGGQDTPIARYYARIREQAELASTGGDDDAPRDGGATPVAPIVPAAGEMHRYWAEKTSTAGRSGSTSALDRPRPPTSGSASFFAGRSRRQDSVNGLAAFKPGAHESAIPTLVRNGDEGATRPLHIVKRTRARGASDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKT9</accession>
    <name>W3VKT9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ROT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein rot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKT9"/>
    <dbReference type="HOGENOM" id="CLU_071622_1_1_1"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833156" description="Protein ROT1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="208" mass="23040" checksum="AF3ED5CD74180C93" modified="2014-03-19" version="1">MLELHTLAMAVLVALAGFVAAQSGQWDDLLDDLAGTWSTGSGAVRTGPGFWNPRTQQFTVPRSAGRSYSFTKDGFWEEAIFQWSNDPTDPHCVTATLLWQHGNFTLLPNNGTLRMDPFWGDGFQSQWIGCDTTASANDNNTLAPVASYNQIEFYQTPAISVDAHYGVASWKLEMAQLSGEPLNPMWKVLNPPSMLPTDVLHIRRYGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLA0</accession>
    <name>W3VLA0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_04279</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_4_3_1"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="263"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="652"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="18">
        <location>
            <begin position="861"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="14">
        <location>
            <begin position="896"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="15">
        <location>
            <begin position="1279"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="15">
        <location>
            <begin position="1470"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS61531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1776" mass="194057" checksum="8ACF4306FD2293FD" modified="2014-03-19" version="1">MSEVRIDFGRLGAAPNKARRLDPESVPPVKAPLTDFVRTHPSSLIVPAAAPIAQWDDSNGERHRLVTVLLGTQARGATAASAVPTAASSAHMRCGIPRQHAPADAASSSSESASAPLPALAPPQLDLEEPARNSVGDTDILSAQARVSNWLADVHLSPPTSSPIPIDDIDIDHLSSIAVTPLSHQSLDTMAKRSRQRSGSPAPSPVDPDVAPSPATPPVVEDEGARKKRRILEHIAAQTAVDPSDQLRTDQLTFVPRSYQLELAQIAKSGNVLVCLDTGSGKTLISVLLLQHIHSQPVPPSIPATQRKVSFFLVNLVPLVHQQSSVIAGNSDLAVGKLYGELKEATRGRNKLTVDNWHAPQWAALLQSHQVIVATAQCFLDALIHGFIKIPDLNLIIFDEVHHALKNHPFFRIMKYYRLAPADQRPKIFGMTASPIFTRSGMFHEAAHYLQSIMDARIHTVSKAALDDLDKVKQKPDELVVEFAPFVTVLDDELGGVPLSDLSREMLAMFAVDVALEDDQLDPVQRHFRDEVQPKLEYTMRHLGAVGCDVFWHSTLLELRSRARKWAAISRDKRTLVSDAWIVDASMRSPRENGDGDDGAEEPQKSPLPLGAAHLSNSSELNRRILLHMRAHPALPDELRIDASNASPKLLRLVELLQCFEPDAANFCAIVFVERRQTATLLVELIKRAPGLGFIHPEFLLGHDNGSAAGGAPAMDWHDQVQVLNRFRRRAPTNLLVATSIAEEGLDIQAANLVIRFDLFNRHISFLQSRGRARARGSRFILMAESGNADHAKVILNAFDTEARRSKWLDAITESGGDGGDADAMLCDEWQQRLHIEPQDPDAEPAIHEPTTGARLYAEDAPSLVAHYAATLHSEHLKDAVLAYRMQCTDVLGGTPAFSCTLELPSTAAVRSVDSGPCSSKKRAKRMAALRACQQLRQLGELDEWLMPKLVGATVADRDAAPVAMNPHHKEWRGTGQPIHVPVKKMDGWARFYAQSTGKEAQWHATFLPMGSFDAGYKPLLLLTRGALPATERLTLYHAASGEMKPIRAASLGAVPLGSTELEAATQFTRFVFALLSRREVGPDDGEPAVLVAPVRVADGVSDVTAWSQLAFDWPATLESSRIDLSELGSLQNRVLTRQHGYASNALYIFRDVRHDLTAISPLPPKAGTETVDETQTYLSQHLTKYARRVNAEEAATLATQLASTPLVAVTKLGKLTNLLTAPSRGSRAAATLVRFIIPRFYRVFPLRSDVLLSVLALPSVLTRYDQLLLASQCNDAVFSGALEVDLVLEALASPAARCGLDYERLEFLGDTFLKLVATCHTFTTQLGRTEAELHLANKGILTNVRLLREARRLQLGRWALFASADFGAKRCTAPMSGWMGGALLQAGPVEVGPGETDVIREKTLPDVVEALIGAALLGGGTDAALHVCRVLTLIPESIRRLDDFNTLLQELKLTSVTQGWERRVDRSGLDHLQSLFGHVYRYPHLGLEAFTHPSLLASVLPSYQRLEFLGDAWLDLYIVRYIFSAHPDLSPGELTALKGMLASNSTLAALGHRLGLHRYVASNSEVLVSTLSAYSTAMEGAGEGTAYWHKVDVGVPKALADVVEASFASIVVDSSFDPSMAQGVFDRLFVPFYSRFCAWDSIPLTDVKRLLLSTNCILTITCSLTNSDEMDVDVLLEELTVSIVMHGTMIAQLKTTPPSLNHLAKAHEILNAVNQKRPEQQRILLAQLARTLAWKTPFQPPEDHIQPTLAHLRILAKNCLCSALTPPSSPRHSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLB4</accession>
    <name>W3VLB4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLB4"/>
    <dbReference type="HOGENOM" id="CLU_270649_0_0_1"/>
    <dbReference type="OrthoDB" id="10255344at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="460"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="671"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="758"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1092" mass="119635" checksum="85CFD2189CB54F9D" modified="2014-03-19" version="1">MGDSSSTPPARSRRISMLPIRDTEPAQAHHRLQVLELENVGLTEELEHVERKNLELERQLDALRATVAQQPQSGLAESHEESVLASTSMSFDASPNYAAEVKGARRLIHRLATHISAHDPSASLPESAPFDDERYFTLDQSLVHDPERSFVTPAVTHLTTPNGKHTVARAFHNDLLDDVETLRSVWEEHTRRATFAAVEAHTHAERQRAMIEQLRTELHNAQAAAASTSTHQLTQQLQAEQQRSAELEAKLTAAEATHDQLAQLTQQLHSEQQRNAELDTELAAARAKIESLSATDMANEATSERIDELEEQLEAERTRSGDLDAQLSSAEARILQLTAEHELTLSAASHKSAAHIGALEQELAERRTRADEVGSILRELADKRQRLHAIQLHTAQVSALQRVLDKQTRIVALLERDETTSADMLAQWSEYARDMSASLALLRPANSNESLTETTPAQGGAREEDAVAGLREKVDELEARVLRRNEQIGHLQRQLSTAENDLKRTRTNQTLAETTVEELEDSLAELEGQRTELQNRVEQLELHVASLPAATAPTEHADAEAQVALDTAQTQRVQELSAALDTARARLEEHIASLPTVTAPELADASAQATLWTTQDGRIAELELALQAAHTRTAELEAQSDELLSLRTALRKATESRASLALELDAVQLALAEQRESASADAERLEQLEAQLATHDADRIQLATLSERIALLEEELSASHAARDSALDLHHTTASELAALVAKHTELEAVLAARDAAMHARNAEYWTLKEELAELQEEAERSRPEIITPAALSTLRSELDTALQRVAAQEEVLLRFKSDLAAARSTEELLNAQYAAAQRRAAELEGAADARPDAELQERLDKAEEETSYLRTRIDELEQELGRKADEIEEADSKILDALKETKKYATRYTKLSARLDDAKQQLVAAHAQTKHAEEELARWKTRADESAVTRASAAVTPSASKPVGVKRKVDEAEAVAVEEVRAVYAPSPSARPTSFTPVRRTKNAVLGLGTPSTAPDGMVRSSSNPSELVAARLSPTKPALGDRTNLAPAAARTSRLAKTTLVPAHPDPVAKAAPAGAADFLARMKAQSRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLD6</accession>
    <name>W3VLD6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-xylanase</fullName>
            <ecNumber evidence="9">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_03438</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLD6"/>
    <dbReference type="HOGENOM" id="CLU_024998_0_0_1"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF88">
        <property type="entry name" value="BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834657" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="108"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="436"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="662" mass="66176" checksum="F84ED771EFB77C8E" modified="2014-03-19" version="1">MVGTKLALLLMLTAGGAMGKTSNVQRLDRASLVRRDNNDRTPGGTPFGPGGAGGQGGNNDRAPGGTPFGPGGSGAGGPPVQASLAAAAPGGQKHWATDASGMKGDELVKNLPEGFFVGSAIDNPDLKDPLAAALLKNMPYVTPGNSLKMQFVYENENSWTELLTASEKANGKGTLKWKYHTLIWGAETSQKMMQQSFSKEAMMKTITDFVTNKLCTKIVKETDFWGIDVLNEVFRDDGQGFKNNGYFEVIGEEGYMEVLKLVKKQCPNQKLIVNEYGMENANPKSDFAFKTIKKWLAQGVPVDVVGLQFHIGPDNKYEDMYNAIHRWTSQDIPVVLSEIDVPINLPPSPQDLEKQAQTYGNLMQAALEGGAFGATFWGMMDSHTWFGTQQDPGVGKGKVGAPLLFDAQGKPKPAFAAIVDVFKKWGKKQAGIANGRATDLGHTSKGGADAKSGPGSDESYGAGAGSNAGAGSNAGAGADAPGAGAGASGPGSHESYGAGAGAAAGGAGAGAPGAGAGSGAGGAGSGDIDMGPPDLGAAPRTPGAGGAGGAPGANGSGAPGAGGPGAGGPGAGAGSPGAPGAPGAPGAPGAPGAGAGAPGSDAPGGGAYGAYGAGSDADAPGAQPGAPAAKHHGHHGHHGHHHGHHGSNEQPQPYRRSLARPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLE4</accession>
    <name>W3VLE4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division control protein 73 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLE4"/>
    <dbReference type="HOGENOM" id="CLU_025849_2_1_1"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000004">
        <property type="entry name" value="Potential RNA Pol II elongation accessory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="281"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="463" mass="50077" checksum="CF7CC05700D9B077" modified="2014-03-19" version="1">MSTMASTSANGADALDLIRSAIKDASIQADPLASIQLLDDHSSPVPSVLQATAVKIRDVSLPKSTTTRLARSRDELAARLASGSPPDPDAEPAFFYNVEAVILALQARDERPGAYLAQAATAKVASFPTLDRAAILDYLLGRRSDWAGVVHIRDLPRAAADGVSAPTSTSAEAAASAPGAQGVKRAYKVNREDVEYVKRIRSQYEVVLRTRNDALRGNIAALVGGAAVSRVAGSKVADFETFRRTFSAKVEASRKAAGKAPPPSAARAGVSAGGQVRKQRAQDPIVVLSSSPTSLLNMFNIKQFLEEGVFVPPEEARQRARGVADLVVSITSRGGSTGQGAQGVGIGRRILVVDSAEAVVRLGSSSAATPGADAWNRVIAVFTTGQMWQFKTYRWNEPRELFKNVMGVYVRWHNEPQNPNVRDWNVIELQVDRAKRHTDKQVVSHFWRQLESWTQRRKPHLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLH6</accession>
    <name>W3VLH6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RPEL repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLH6"/>
    <dbReference type="HOGENOM" id="CLU_121574_1_0_1"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21255" checksum="7FE59F5CA20A7D55" modified="2014-03-19" version="1">MTTLGNLDIGAANAGGSAEAGAPKSPLTETERARLERSLGHRPDRHELEERNILKPGNLAPALQAKRDELQKSQLADRLEGRLERRPEKDDLVNRGILKDQSVAPALQAKREELQKSQLTDKLEGRLERRPEKDDLVNRGILKDQSVAPALQGKKEELERARLGNSLQKELEHRPDPEELRQKGILPQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLI9</accession>
    <name>W3VLI9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLI9"/>
    <dbReference type="HOGENOM" id="CLU_015166_6_3_1"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="120"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="244"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="348" mass="37719" checksum="C7FE6F6C6D11B41F" modified="2014-03-19" version="1">MAQSQLPPFAQATAGALGSLTSNTLVYPLDLLSTRCQTQSRGRDGKGGYRSIGAALSEIIQQNGIKGLYQGLASDSISNTLSNFLFFYFRSFFMEAIQERKRAKLPPSSGGKGKGKSIVITAAEDLAIGALAGIVSRLFTTPLSNVTVRMQTSATPKAKNKQVEGAKEATKQPSSDSDSDDEGGYAESPGIMDVLRQIVDEKGWLGLWSGFETAAMLSISPALTFYSTNAVSTLLIPKERREKPSSLQTFVTSAIGNSISTMIVFPLILCKTRLQWRSPSGRKMYRNLLDVLRKTIRRGGLAGLYQGLDTQLLKGLFSFGTTMMVKARIETLFVMLFLAVRNKKAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLK6</accession>
    <name>W3VLK6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLK6"/>
    <dbReference type="HOGENOM" id="CLU_076131_0_0_1"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="32666" checksum="EF73F41B2ACA8F80" modified="2014-03-19" version="1">MEEHAAASSSTLSLDAPRRMPAYLPSTTDKPASLPRAYLNGTQDMLQLFGLMPIYDRAVRPYNPDTIKAEAAAAAATEAPAEASTSKASNARSGAASTRIPTVAAAGAASSPAPGVASAASATPSGSIRPATGSNSAVAGMQNPPSHPSSGTGRISTPALQLNGGASTFALHTDSSAILAASPGQIAASAAAAPPARRLTKPPPTYAHYVDDLAGRVRPPRKGTKAARTQKGDSLLSILFKPEYTPQRIVLLDRETMSAAFTVQPGPVAEIDHALLEPDDEEAPRPRKKKKKLKQEQSATMHASSGPPSAARTPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLP9</accession>
    <name>W3VLP9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLP9"/>
    <dbReference type="HOGENOM" id="CLU_871916_0_0_1"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="5">
        <location>
            <begin position="153"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="319" mass="33475" checksum="0C9139470B6747AE" modified="2014-03-19" version="1">MASSSSVGTASLASASSAAAFYTHFTQATDALRAQICDASDATALHAALQRLSALNAELTAAVDSGVLPAHDQALHRRALDEITATLDQRRRAIQPAKAVGGRFAFRRKPAQPARSAPQATITSESTPVTSAEDAAGADRLAITSLSHTSYLPPPQEALRLSVHVCHVTNSLVDLRSISAKVVSVQLRDIRDSILLLPAIEGSVMAHGIVHSLVGIPSCHQFRMHASTRVAVQLATKRSSVVTIEACRSLVFVADSEAFKVQDFDDLIGSHQLASSTPHHAAAPSSNFRVVQASVSIDALGATQTVEARIDEALTTLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM12</accession>
    <name>W3VM12_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM12"/>
    <dbReference type="HOGENOM" id="CLU_060354_1_2_1"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="169" mass="19063" checksum="CCB48FBBE9027788" modified="2014-03-19" version="1">MSIVHLQSVEILNAEARFEDAYIFKITFECISPLQDDIEWRLVYVGSAGDEKYDQELDNCMVGPVPVGVNSFEFEAAAPSPSKIPPEDLLGVTVILLTASYRDQEFIRVGYYVNNAYESEELRENPPEVVDLTKVRRSVLVAKPRVTRFNIKWDDAPTAPSQPEPTPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM16</accession>
    <name>W3VM16_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM16"/>
    <dbReference type="HOGENOM" id="CLU_055159_0_0_1"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="350" mass="36297" checksum="115666A35D6207DD" modified="2014-03-19" version="1">MSDATTSSAAPAQEHQADAATAHNGSGEHVDETAQRSEPSSAAVAAAAAAALDPNADPAERDHIERDVSNILAGLNQEQLASIVAAARASEARNGDAADGAAFGDGIASGLGQAASALTSIASGLKRSAANDKADAKDLGDAPPPPGVEYPDQLDGKELDADTSAAIAAVKSATDSATAAAIASLGSLAAASHLQQPQAGQAQPHTGAGEADESMDYDSAGGSASPARGLKRPRGPELDRQRKDNHKEVERRRRSAINDGIMQLSMIVPGCEEKNTNKGAIIHAAARYIQDLKHNEASNIEKWTLEKLLMDQAMGDLTAQLDDARAQIDRLRAELDNRYSHQIPPDHHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM39</accession>
    <name>W3VM39_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM39"/>
    <dbReference type="HOGENOM" id="CLU_043293_1_1_1"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="177"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="396" mass="44209" checksum="1F2E3B0CA1FFBB4D" modified="2014-03-19" version="1">MTAFANATLTATGLAKLNQTPFYFQAQPSVVPGISDTHLSLALPIVIYWVTSLFYHLLDTLQLPITEKYRLHEPEEVTKRNRVGVTRVVVMVVVQQIIQTVLGLLLLDDDVVGLKQTFADHPAKITSIAAFLRSTTDTLVGPSLQSSVTKLLFGSQDALSAAWWLYWWGIPTAQFWFAFFVMDAWQYMLHRLFHESRFLYRHFHSHHHRLYVPYAFGALYNHPVEGLLLDSGGAVISHAASLMTLRQGILLFTFSTLKTVADHGGYAFPWYLDPLHLLFPNCAEYHDVHHQMTGLRYNYSQPFFVHFDVLFGTRISAEKFQKMKKLAEAKRAAEKQQAISPANGNGTANGNGSGAAAEKQQLKGKDASPAEIVAKTNDPFTTSDKQSYAAKAGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMA6</accession>
    <name>W3VMA6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMA6"/>
    <dbReference type="HOGENOM" id="CLU_041558_0_0_1"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000071">
        <property type="entry name" value="Dihydroorotase, homodimeric type, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="65"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="392" mass="42121" checksum="12A39630F1D0AF36" modified="2014-03-19" version="1">MSVQEINVPAPADFHVHLRQGKMSELVSPHVAEGGVALAYVMPNLVPPITSAQQASDYLASLSALAPQTKFVGTLYLSPALTPDEIARAAQAGVRGVKSYPRGVTTNSEGGIEDYETYYPIFEAMQKHNMVLNLHGEVPSNADAGICVLNAEEKFLTHLFKIHRQFPHLKIVLEHATTRKAVEAVKQCGDTVGCTITPHHLELIVDDWAGKPLNFCKPVAKYPDDRQALRDVIREGHPRFFLGSDSAPHPLANKYPSAVTHGAPGTKASSSGDEDLEPTGVVSCGCAAGVYTSSILVPLCATLLEGFGALDQLANYVSLNGRKFYGYDSADDMKNGSITLRRASKGATGSAATVPAVYVHPEYVEVADSDASKVQVVPFWAGKRLGWEIVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMS8</accession>
    <name>W3VMS8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMS8"/>
    <dbReference type="HOGENOM" id="CLU_676395_0_0_1"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="407" mass="45490" checksum="556657C0C608FD15" modified="2014-03-19" version="1">MMSAGTADYRHYQDQSRKNPGRFGPAPPSFPLNSPPTFYPSLHRPDPFVAGGNLGTQISSSSRDSRSLDFDYQLFGKLSLDDVPSPPAQRSSQLIDWSWDLPVESSKEQASWINKTSKPSIWAELETHKEQPRIIGNASAQSNDLASGSLDVSIFDEPVSKVPYWTRTSFGSYHGSDSDASSPLGDETRHWPRSPPEPFPAPVQLGKLSPHAHTFSWQGPQVASAFTATDLPRSMSAPSTGPGILAGASQESRLMSQLQGHGNHRTGQQYNFFLMHDTFTAPRPVEPRQAKDAWSGRQAAAPSPSPNNKKMELFKTEICRNWEERGKCLYGNRCQYAHGEEELRRLPRDPRWKTRPCKVFMLYGHCPYASRCCFRHDQGGVPSQPIPTMQRRVSLLQRVGLIKPCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMU5</accession>
    <name>W3VMU5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMU5"/>
    <dbReference type="HOGENOM" id="CLU_009601_2_1_1"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="615"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="760" mass="82830" checksum="EEF9E9760FAB1061" modified="2014-03-19" version="1">MVPPPPVPQRPSSQKFTLRFTNLQPGESVYTRLLIVEGTVGSGSPSGQLTVSHDLTSGFEEQIWEINQGYFKALVPLTPGKNDLTLNWTINGSSEHGSETVSVTYDRPSSAPPLHLVIVAACDSPVWQNDGRKPPVVPPRPSGNEATNSAQPRKADKVSRFLNRAMDRLDIAAGPRGGPVDEADRAIVDAPPGPRREALRSGGIAEVKCRIALQAYLWQAFHAEQMRRHGMGRRAFQLDDAHSDPAPGSSSAPKRALESLPHIHLLKSRRSLREFRDPENAQQKSNARNAGAMHGFAREALEDPSTPQFLRWSPVAVLTLDTMYDAKMRLIRAHAALGAGGPGSLSHGVMGSHWLWAAPSSLQQVTTAFLDTEPTDEECCVNDLNECPTAWQTLNIGSGAFFHEAGHALNNPHWPSGLMARGYVEFNRAFMTREPGCRRNGVAAGGFFAPIHAGNDDEHNHIHRAQAVRARWHPCFYIPSDPPLPYLRANDQATWVQWNENEPAWTSTPQGALLKCESGIGTLEIEVDGAYKTHIEWLNLPIDGRPPQVPPRQTVIDAAYLSQKVGFDVSHPTSPRIKLNALACNMRQAELPDFRQNGVARPLRLPGIDSSRRTIVRSLPFGQTNTSGRQWDVIFPHERDDTPHAHLVAIDIFSGASLDGLQFHYANGPRVVFGPCGGSPFRLTVDRGDAVAQIKVRAGAWIDAVEVVLRSGKTSGMRGNVTGGSLRTLEPASGEGRIVGLYGTSGAWMDSIGAYTSAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMV0</accession>
    <name>W3VMV0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Purine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMV0"/>
    <dbReference type="HOGENOM" id="CLU_024508_3_2_1"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="67935" checksum="39C0ABC1CAF8D536" modified="2014-03-19" version="1">MGVPELINNLNRAVATSPVGYYFRLDGSGHPLSRPGSRFLTELRAGLVTFAAMAYILSVNASILSSSGGPCECANTADDPVCAKDAAYQQCTAVLNRDYVFATAISACVGTLLMALFANMPLGLAPGLGVNAYFAFTIVGTAGTGIIPYSQALSAVWLEGWIFFILSLFGIRQWLARLLPHSIKLSTGAGIGIFLAFIGLGPNGLGVIGGNASDLIGLAGCPAQYEDPDTGFCLSHKLQAPTVWLGVMLGGIFTALMLLYRVKGAFLIGILLVSIVSWPRNTSVTLFPHTPSGDDAFNYFKQVANWNGLGLLGPKNIDWSGYSNGKVWYALISFLYIDLLDTTGTLYAMASHAGLMDARTGDFEGSSAAYLSDAVAISIGSLVGCSPNTAFVESASGIAEGGRTGLTGLVVAFMFFLSLFFAPIFASFPSWATGSTLVIVGSMMASNTAQVNWSYVGDAIPAFVTIVGIPLFFNIAYGLIAGICCYIALNAIPWALVKLSKGRIVPDGWDTMKEPWGARMVSANDDSTGIWAVLPPWMRKVMSGNYKFWQMTEDEIEFYLEGRRETQRLAQERQDQIENERNAMYGADDVEARASTSSAEHADEKHSTGSPAFSPVEVPARLPNDAEVHHVTGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMV8</accession>
    <name>W3VMV8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMV8"/>
    <dbReference type="HOGENOM" id="CLU_584115_0_0_1"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="493" mass="52418" checksum="B625C736B7679A8A" modified="2014-03-19" version="1">MTPRDPVYPASNSALDDFPVHAYTNPHSHASASASPHVMQSYSHLYEPINHSSASTSPHPSSPGGINIPYAGSPSSTSIPHNLSSFGAFYIQHPAATTPTQPNHASGSTHHHHHHLDSYASSANTPHQHLSPSADHHSSSSASVAAFSNSGRLSWANSPADSYHGVPSNATTHSSGAESHSSFANHKYPWDLNSTSLRSDAPPHIGSPYSASDLLHPATASALGLDDDSGSGGNVRPRARKRTRAEEEPRSRLSSSSRSRTRPRIPSALSNANSPASDFHHSISSYHPDPEDTDITAWINAGDAEDFGASHVGAADHSRLWSSFGPGITTDVGHSSPYHGSASASALPASLSNSRAQSVVGSDEFGYPASSALHAGPSNLGLASVHGDVPTAEAQTEGVADEEPAEDEPLYVNAKQYQRILKRRATRARIEEQRKKEFLAHMHAREKAGKEDGLDEEGKKPYLHESRHRHAVRRPRGPGGRFLTKAEMAAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMZ2</accession>
    <name>W3VMZ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">PaG_02612</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMZ2"/>
    <dbReference type="HOGENOM" id="CLU_027721_9_0_1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="194"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="480"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS62855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="544" mass="60415" checksum="D816FB5B9F3A1450" modified="2014-03-19" version="1">MSAALSQAGLPMEHSGRREDIDDDDYPSSESDAEIDVHAPPAESQRLLAADEDANATQDRAGPSIPAQVARAHGRKRQTPLKWTEIIWVSCTLSLIAILGYSSQLCIMLPYYNKTPSFSAQALAAVLVPFNLGLLGIFYNYYLCVTTDPGSVPHGYQPEWSALEPVSSPHHHPGPHAGAGEMEPSLELKQAIYRPRYCKTCSAYKPPRSHHCKTCERCVLRMDHHCPWLANCVGHHNYAHFLRFLFCVDVTCAYHLCMVSARVLDRFNAYTYWREPSTRELIWLVVNYALCLPVLLLVGVFSAYHFYCTAINQTTIESWEKDRTATMIRRGRIRRIKYPYHLGVARNVRCVLGDNVLTWCLPGQAAGGDGLKFPVAPGLGRGALVAPAAQAVSLIRVLSPRALSSIEPCILASQSELVLTSSFLRPLDEASQYRWPPKDPAKTIHHTAPPAVYEQSSGWYGEPAAPHLFPPGASSNSPFTYGDGFNPALRPSNQTYTQSEVESDVESDVESDVDDDHADQLRRRVAVRRGSEGYEVRPVAQWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN16</accession>
    <name>W3VN16_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_03745</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN16"/>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="726"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="530"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS62177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="796" mass="85939" checksum="54DF48A2BBF23A7B" modified="2014-03-19" version="1">MLPLRALRSSSLRAAAKAPLARGYATTVAEEAAEISPSLFDKKVEMSVVEKGKGYYVNYKRIEDNLKVVRSRLNRPLSLAEKIVYGHLDNPHEQEISRGQSYLKLRPDRVACQDATAQMALLQFMSAGLPTVAVPTTVHCDHLIEAQVGGAKDLARAIEINKEVYDFLATATAKYGIGFWKPGSGIIHQIILENYAFPGGLMIGTDSHTPNAGGLGMIACGVGGADAVDVMADIPWELKAPKVIGVELKGKLSGWTTPKDVILKVAGELTVKGGTGAIIEYKGAGVESLSCTGMATICNMGAEIGATTSVFPYNERMGDYLRATNRSEIADLAKGFQRNLLPDSGAEYDSHIEINLDTLEPHINGPFTPDLATPLSKFAEEVKKNDWPEELKVSLIGSCTNSSYEDMSRSASIAEEAAAHGLKVKSQFTITPGSEQIRATIERDGQMEALEKAGGMVLANACGPCIGQWDRKDIKKGDKNSIITSYNRNFTGRNDANPATHAFVASPDLVTAMAFAGRLTFNPMTDSLKGADGKEFKFTAPSGKELPPRGYDPGNNTYQDPPKDRSSVQVAIDPKSDRLQKLEPFKPWNGKNPTDCPVLIKAQGKCTTDHISAGGPWLKYRGHLENISNNCLIGAINAANGKANEVQNVFSGEWGPVPATAIQYREQGKPWVVIGDENYGEGSSREHAALEPRFLGGCAVIARSFARIHQTNLRKQGMLAFEFANPADYDKVRSDDLVDIIGVTELAEGSKVSLVCKHKDGSKDELPLTHTMNDNQISWFKHGSALNKMAAAAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN47</accession>
    <name>W3VN47_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN47"/>
    <dbReference type="HOGENOM" id="CLU_1005196_0_0_1"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="242" mass="26564" checksum="D55AAEE0A108C5BF" modified="2014-03-19" version="1">MGSSSSKPARKLGSEVASTVSRSVPSAAKAKPNPAPAASARVPPTEYAASTAQQSSQFAPSAATRREQETQRQQSQASETKSADIMRDAYDPQFLHNLSRLGQVQVPKNATNYQPNDQMLRILEARERANLDNIQSDVFASSSTPAKTSGPARIPAHTITMLLDDRKHCETRADLEKLAVEYDLSLATIEKLARYYNSPTMGEEVRDESDNVQDQANRQDERAPPKVKGVWVEPKLQSQIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNA5</accession>
    <name>W3VNA5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNA5"/>
    <dbReference type="HOGENOM" id="CLU_033072_0_0_1"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="2">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="248"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="508"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="603" mass="66125" checksum="8F7EF395C5D49490" modified="2014-03-19" version="1">MRASLPQTALRSASSRPLAAPALHTSSRAALSIQLATAPTYLGQRRGLFGFSLFGGKKSKKNDPFALPPRAAKKPLLAQDDLFHPFSKSPIPSIRARGERIRSLAPCPVSMSKYKVRRLVNFECPDCGWPTHYSEKEWAEDTEHGKYVARLREANEDEHDLRSGREMSEFKLPGPQGFEETINMSNWDVFFYTRNFNSIESDRSRRHVSKLLTFPTTMGAVIHENSPFTKKSRRLTHEGLRSMIALRQTLHPKAGDKPSLDKMRIFVVGARAESTLPPAVWDQLTYMFPGVPFHLFLIGPEAHIPTDKQVQMQDRAAPGSGGISMHKGRVRTSNYGVPSRTVVVSEGLTVTTIQSKYEDVHAQLEPFDAYTDVFFAFSPGFGFPSQIAVEEADQVRQDERDHEAHFARAKSTYHAAGAESAESTEASAQKAADDAVELAKAQIVEQQQQTGASGAVPDAAASPSRAAYTVDATSSPEGGDVPSEEPAPVLASADGHTFTALTAAPVVQAQREWARAIGQILSTRCALIATGFSPADVERDVLAFESVDGVRGEFDWLVTPGENPFASQQWAVADFDPRVAVKANWGIWAVRGKRYDIQGPTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNJ0</accession>
    <name>W3VNJ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNJ0"/>
    <dbReference type="HOGENOM" id="CLU_392829_0_0_1"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF84">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="77282" checksum="9A4212893AF74EE2" modified="2014-03-19" version="1">MSAPTLPGAQAGPSSQPAAASVPAVPASQRAREIQDALKAIVLQTASTLRARNQQARLPTSVASSSVPAATSISESSVNLEQLTGECTRYLSLVHGLRDYLLHAQAALEIELEAATQREAQEAKIAAEAAAEALQRQQEAEADAQRKAAEEAQTKAEPDAVASAVASKDAKSEEAGGHADKKEGDEDDSMVSTPPLPPAERTERADVAAHTATTGKAGEAAKDAIVIDSDGDDDEDDVPLAFAPKPGAAIDLTDSPALANAPKPSTSATDAASTSTAPTQAGTDPAPTHASAPPATVPNTVAGIDLSALGINLSSLNDLADLSSLGIPALGGSTSGDTTALAPATDFSELEKMMGMGFPTSSAPDASTAAPDLSSLGNFNLGSTGFGEDTDMFGAGTGAIDLSNFDFSSLTAGTTDAGAADAGVDLSSFLTNFNPAQLDAWLALVTVSASQQDHAKHPRSVLRADVASSGCGYAKKDTMISQPCGSSRPSKGVGGALSYHTSSYWNARFATDPREAAGFEWLSSSSSLLSSIPPSILASSSPKILHIGVGTSSLSLDLARYFHAQDGHCSRAAGVMNVDFAPRSIEFQCTAERQWLESIKHADQVMQYKVLDLLDWSQVCEMQGGFDVVLDKSTADSISTGQDLHLDSLDSNVHPAIRKLAQHDRAIPTIQILGIHLAALVSRGGVWLCHSYSSDRWADLVIPPHEAQEAWPWNLTETTAIPVESSTPNAPQIHHHIYTLHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNR3</accession>
    <name>W3VNR3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNR3"/>
    <dbReference type="HOGENOM" id="CLU_1343791_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="204" mass="22583" checksum="DCC0E22B0C6AAC90" modified="2014-03-19" version="1">MSYERQQNDAILGDLFADPTCRSEWDTHSPHVWWFSQVGSMSNCGPRRPSRRPSTALFGSNGVRKSRHCPLAPPSGLVDKAVWGPSATVGYWSHKRARLEIFGHWWKGAKKRADIIAPRRRRSSVVSLVSTQVVKKMTDTADPLKAADRREEEGGRESTRGGIPDVRGQIADRCSAGPMDGDLVGTEEPSSLCDASTRKRRKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNV6</accession>
    <name>W3VNV6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNV6"/>
    <dbReference type="HOGENOM" id="CLU_1797285_0_0_1"/>
    <dbReference type="OrthoDB" id="10624895at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="144" mass="15499" checksum="EB829BFD0342893C" modified="2014-03-19" version="1">MPKRAASRDERAGRGVGAARSTETNTERQFGSAPKKSGRTSRGKRLLQPRPSALSRRLARYQQPSAPPVQTSPPIHRSNSRPRSSYRKLMHARATGVQHHPGLASLMARHAQTSAALAYTRDCLAPISAADAISAAVQHAMLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNY9</accession>
    <name>W3VNY9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNY9"/>
    <dbReference type="HOGENOM" id="CLU_1533216_0_0_1"/>
    <dbReference type="OrthoDB" id="10630939at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="175" mass="18395" checksum="2FFD60AADE375605" modified="2014-03-19" version="1">MLMMAVQDEQSKDDWVSEGDARETWADLRWGHAGNGPSATLGCHAFRRASGWRHLLLHDWYNVSSSVRETVLVNVYASGGASLAKHADAGLASFSILAEAVPHSHPEFATQGHGLSQTGGQPLATTSSSSTLAAGTAKPTTLESLTISLAGTEARDPGWLAAAAPTSAELWQTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP80</accession>
    <name>W3VP80_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01635</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP80"/>
    <dbReference type="HOGENOM" id="CLU_397475_0_0_1"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000172">
        <property type="entry name" value="Related to choline-phosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="534"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="693" mass="73457" checksum="24305E65718E92A7" modified="2014-03-19" version="1">MAAPSRTPHSGSGSSVASAAASAQAPASSLSPTSPVGQTHPHHHHHHHHHHHHHHAHHITDPARRKKKHLPAQLAQLQLENEDEDANNFISSSRDASEEDNDDQEETFDDDASIASLRQHQQGASTSSLTSVPISSSLSSIPPNDRDQALIDSAALHQPSKLQHQLKPTSALDDKTPASTSPPRVAAAPAVASATGIAGAPTRTAQPNVQHGFVSPTQQQNQSSQDRRREASSDDDDRYVRPSVGATLANASAALSSSSSTELLPKAIVAQRQAAHPVGAASDRSAKGTSGANLNLGSLPSPNLAGGASSSQPLSTVKPQSQAIDPISSAAAAVTPKAQQVSETSAAPALDNASVGQAVTSSGISPAAKRKTSASHHASTASARRAEIHDGAAEEAGNNTDGATPYDGDVEYAARTPASVPAGTSSSGGTVPTQRDTSKSASAANRAPAKSTAPGPVRSLSYIETMKSKHADCQPEGDEFEEGGFQPSSIPSAEEIQAWVNQAIFKPDAQRDYSINPPPKRYDSEGRERPIRIYADGVYDLFHYAHALQLRQAKLSFPSVHLIVGVVSSFSCGKHKNKPVLTSQERYECVRNCRWVDEVLEDAPWVVDQKLIDTLEIDYIAHDDLPYSGIGMEDIYAFVKKQGRFLPTRRTDGVSTSELLGRIVEVYREGSLDGKLTKIGLEDLTSTHIPKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP88</accession>
    <name>W3VP88_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP88"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="78"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="601" mass="65315" checksum="2F62A345850C2E79" modified="2014-03-19" version="1">MSTSIKQETMSSPVDSVADPDQYTLRKTPFRLHVTPFSEILNKKYDGAGTKEDPFLVEWLPSDAENPQNWPAYYKWLLTIQVAIATLSVALASSAYSGAIESLQAQFHPSKQIILTLGVSVFVLGFAFGPLFWAPFSEVVGRRNLLIFTYAVFTMWQAVSVASPNIESLIVFRFLAGFFGSSPLVNTGGTLADMFNANQRGLAMAIFASAPFLGPALGPITGGFLGESAGWKWVIGFLAIFAAVITVLGAVSMPETYAPVLLRWRAQKLSEVTGRHYICKLDKGRDLRLKTQFKVALSRPWLLLFYEPIVSLLSVYIAVIYGVLYSLFGAFPIVFQRGRGWSPGIGGLAFLGVLVGMLIALAYIIFFENPRYIRIANKFGGIAPPETRLVPAMIGAVAIVIGLAIFAATDSPDLPWIAPIIGGGPFGLGMVLIFLSTMSYLTDAYLIYAASVLASNSVIRSLFGFAFPLFTTDMYQIGGKNGIHWGPAIAGLLALICLPFPFIFYKYGAHIRERCKYASEAKQMLEQMQSSSKAKQPAQAAKQDDVDLEGGEKTARTDSNTDSAKAATTTRPSLEVDPSTQAHTPDNESHSGSESSHHGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPE2</accession>
    <name>W3VPE2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPE2"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="146"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="610" mass="66048" checksum="ABB3729F89FD4707" modified="2014-03-19" version="1">MAQSSTHHDTANESRRAPLPWYQDTVWGVMVNKFSHGKSLPYPEQKSDFVAPERYQSGYRTRHASEASPLSPASSSSSSASGVSGPTRVNSDDAPATTKPDKANDGNAESAPDDENDDSHPYLVDWDGPNDPDNPLNWTSGRKFFVTGLLCLLTFSVYMGSAIYTPGVELVAAYFGVGTVPATLGLTLFVFGYGLGPMVGLSSISEIPAIGRSAPYLVTLFIFVILQIPTALVNNIAGFMILRFLAGFFGSPPLATGGASIGDMYSPRVRPLAIGVWGLSAVCGPVLGPLIGGFASQSFGREGWRWTIWPLLMLSGFSLVVLIIALPETSAANILVRRAQRLRKVTGNPHLRTKGEIFSAHLTGKELALMTFVRPYVLSFTEPIVLGVNLSIGLVYGVLYLWFEAFPLVFVQTYGFNSGELGLAFMGIFVGAVVIYWPFYLWVKHSYQPLFDRQNGKVAPEKWLEPAMVGTWAIPVCLFGFGWTATASIHWMAPIALSSLFSVGTFLIFQSGLSYLGDCYPEYIASVYAGNDFFRAAIGGALPLVARAMFNNLQSNGPRAFPVSWGCTLIGCVSIPMCFIPLLLHRYGPKLRSISKYTVHGGANGGSEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPE3</accession>
    <name>W3VPE3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPE3"/>
    <dbReference type="HOGENOM" id="CLU_1245842_0_0_1"/>
    <dbReference type="OrthoDB" id="10355571at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="222" mass="24906" checksum="4502C273A9DB84F7" modified="2014-03-19" version="1">MSRDLSPTRGIESAELTLTALSLRRPGARTTRSSLYGSDWSSSGSSDADTDSESIFVRVPTRRPTRARGVRPGLLNLDHPPSPFGACRLGAPRPPRPPRPMADQAKAEPEIDEPQEMVPRPDPEYVYEALRSAWHSIEALAREHVPPLMRWLSGAEHPDQLAPIVPITFLAALLLRPKWVWSTVRFAALFVKETARFYIVIVRDGPFGLFRQTVYHHVLSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPF6</accession>
    <name>W3VPF6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPF6"/>
    <dbReference type="HOGENOM" id="CLU_359101_0_0_1"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833155" evidence="2">
        <location>
            <begin position="21"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="802" mass="83599" checksum="5F19DFDB06B07C89" modified="2014-03-19" version="1">MTRFYVVLWIYVACLGLVSGHGDIPNARRHSGVRARLWGRAMRVWTPRQGPARRSVSEHGSMPEPFLENGSPGWTFDNIYNVAHWDGGDKATCPAPAKSLPATGSKTIQKGFKQEFVHFCQHGNTPTRIPDQSVCITKPHKVSSRGSKVKREEDESDYEARIIAASLATAAEDDATNDDAALSKRTPLAAAPMMGMMGGGGMPGMSTFMPLINTGIDAGSKLGVAFLQYLTQREKDQAEAKKADPLAGARNSTQAAGDPLAASTASLTDKASALTPATSSADGSSGSSSGASGIDGAATTGASGSADSSGITDTAASDTTSPKPDADSPSTVGGATTEKGSSGDTGSEDTGPSEAGDSGSRLAKSSLADDVVGSSATKSMSSGLKSVGSAKDSSAPDDADDLSGTSVKASLPRARSSAGSAKVGGSTLDSSAIGGSTDVGSAMGGSAGGSSKAGTSGHAASSLGFKGKSKRDATPHPVTHSDPATTGSSSKCGGSAVQCKKLIERSIPYCVPHKPAPDAPPHTHDDDDPDAVLSSKMVGTMIRVMARHCLRKCPGFVGLAKSDHDFKSKTEKCAHDTKLFNKSLAHSSKPAHKHSPTTENALESKQPKPEHASEPEKASKQPPAPDAAKDEAGPMFKRDVTPARLPEQCRGGYEAVFRNALQPVSAYQGQLFGSVVSDPGSFLHWGLVRNVAQCKRACDETQGCVFVNVYQQTFGLDHPNIRLVSRDVNDEVKLRKQFAGKPEAKKNSFVEGHLTCALYSRCFRGCQATHRSGENPVFFEKSMGYCKSDKCNPAHSPFTRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPH6</accession>
    <name>W3VPH6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPH6"/>
    <dbReference type="HOGENOM" id="CLU_1023503_0_0_1"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30416" checksum="C9E72C2BDF4463C2" modified="2014-03-19" version="1">MADTKQTQKGRKTRSALNDVVTREYTVNLHKRVHDTAFKKRAPRAIKEVVAFAQKAMGTQDVRLDPKLNQEVWKYGVKNFPRRLRVRLERKRNDDEGAKEKLYTYAMPVLGLGTCKGLQTTVIDQDATVSQSGPSSRFLHTAASAVEATLRACVVLLASSIHSRYWGDGLFRPRSILYLYKKQSSTTKTSLFTPARRVRPTASVMSTRTVVAQWFGIGGAFPWAETGAFERSTFASDGETPVQTSMSRSQLAHFRWRAGRGCALDVRRLGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPM6</accession>
    <name>W3VPM6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPM6"/>
    <dbReference type="HOGENOM" id="CLU_045434_0_0_1"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="71"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="476" mass="51518" checksum="ACD5EA7154ECB4D6" modified="2014-03-19" version="1">MSTSDTTNTHGTPPFDSPTLHPADLDSADELGWSDASSLASLNGYDSVDESNDSPGTAAPEDRQAYPPDPNEASDQAVCRICLESASSGAAGESLGRLLSPCKCKGTMKYVHASCLDTWRAASLRSSSAVACDQCGAPYRFRKSKFIGIATSPTLLFLVSLFLFLMLIWTVGAAATLVMDLYDKPATIAKTEKRGWWPWRSDDDPTISPVETDAWSYLDADYATPGLWSYSNLIYEPAAYIKLVKDAVHAFASGEAADAVREVVGLQDQPEQAQPADETPQQGFWSALKSEWMHGDGGLWPSKSTSLQPDASQSNAPPDTPASETRKRQKYDARAASDINGSKRRRHKSRSPNASSTPGNGWLSKLFVQFSVGFSLVGILSFLNLVVLAPINLHNFGLGRSFARMTSRGRGGAGGRNANQDGVNIASVLIVLLVVIGVVRALHVVYRLVKKVARRGLSRLEEVIVDWNHEDELAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPV5</accession>
    <name>W3VPV5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02532</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPV5"/>
    <dbReference type="HOGENOM" id="CLU_054098_0_0_1"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="12">
        <location>
            <begin position="38"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="215"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="305"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="343" mass="35225" checksum="2C9F487E8E60A2B1" modified="2014-03-19" version="1">MSPPVATDAAFSHASNGVVSSTAVDPTGTVLVIGSMASAQSGSYQKVIEAYSGRQVEMHMVDRLTDGATALAPSTYPIAHLVVSYADAASPLLLSSLHAALQPSAKIVVEAGELTDATTAQKVNAELTIAGFTDIHTDSATGVVSATKPSGAAASFSIGSSSGASSSALPLRKKLGASSAAAKKSLWATQPASANELIDQSTLLRDGDFVATTAVKRPDCDVGPGQGKKKKACKGCTCGLRELQEEEERNANVVQLDTEDMDMPNAAPAEGGKRTEVTETIIGKDGKPKTIKRIQVDTKGATSSCGSCFLGDAFRCSSCPYLGLPAFEPGQKVEIPAGMDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPZ1</accession>
    <name>W3VPZ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPZ1"/>
    <dbReference type="HOGENOM" id="CLU_049056_0_0_1"/>
    <dbReference type="OrthoDB" id="5588482at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833286" description="DUF7729 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="36"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="335" mass="35198" checksum="5C0C80DA9C6F358C" modified="2014-03-19" version="1">MKSFTFSAASSLAAMLLVLAPSAAQVAAQATNASAIPTNVSASCSSFLSTLNSDTQLDACTKPLLQATRIYSSNATDSSTQLDSTLTELCSADTGCDPNIIRARLDQFWQNCHTDLQSKNTQVQAMYDNLYMITPLVNSICAKDKNADYCLKTIAKAAASSQRVAATTPSRRSLDADADEEEDDDDEEWDDEDAEELVKRQSTSSTDTITGLTNATDSSAKPNTNAAFLFISSSSPKSILCSQCTQLILASYIKFETSIPYAIGLRTSEILAPQSDIYKAAKSQCGNDFVVQVNKIANTTGFAAVASSAPGVGARSGVAALATLAAAAVVAIVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ48</accession>
    <name>W3VQ48_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ48"/>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_1"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="89"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="950" mass="100791" checksum="535594FC2A5F3516" modified="2014-03-19" version="1">MSLARSSIGKRASLVSCLTISTSRAALACRATAPRAAARCSYLTSNALPSRSADSTLQSPHTHARYFCSSPRWSVADSGLPHAEKHPVAALRNISIIAHIDAGKTTLTERLLHLTDALAANGGGGSTAALPGDVDSGSTVTDFLEQERQRGITIQSAAVGPVWWPKPSSSKATGTRETVGITLVDTPGHIDFVIEVERALRVVDGAVVVLDGVEGVESQTENVWSQAARYDVKASILFINKLDRMGSSVTQSLRSVIRSGMHQRPLLLQLPIPLKSKDEPGVSGLVDLVEMQTLAFSGKAGETVTRKPLQEADEMHAEAKQARHALVECLASLDDQLLEELFSLPTSSNEEPHGKMPAASLRQAIRRQTLAGTVLPVLCGSAAKNVGVQPLLDAIADYLPSPTDKPSVVGNVAHRAGKNDAKADAGAEVSLSLKDKRTTALAFKVVHDKRRGPTTFVRVYSGTLQRSSVLFNTTTGARERLSRVLFPFADQYVETASLRAGQIGVILGLRDTRTGDTLVDVSSTPAGSKSDKGLDAADAKTLRLKRVHIPPPVFSMSLEPASKSDVDAVSDALNLLIRTDPSLRLDEGSSAGAGTTGQTVLSGMGELHLEIAKDRLENEFGVNARMGAVRVSYRETVDEGAGELEASEVVERDLAGKRIKIGARIRVSALAEDEQHRISQPDAAVFGGNVVDIVLASPPTSGQSTSGGKGSSKAAGKEDSTTIGLPAGVDMASVEAMFKSGMVAALSRGPLTSNPLMGLRVTVDNIEMFGDLSSSAAISYVLSHLVRKVLRTEPKLDPQTGMVVQPSQARTVLMEPMMATRITVPAVHLGKVINDITAEQDGLVNDVVHQTSSQQDGSETEEQAEDAVYIPPRESRFEMQSASAASGRGEAEKQAGKAEIHAVVPLANLVRYSSKLRALTAGNAQFNMQLQGFARVSQHRQAEILADLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ51</accession>
    <name>W3VQ51_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_01909</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ51"/>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS63610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="181" mass="20606" checksum="3186E9959D87207B" modified="2014-03-19" version="1">MGMSISKLLSGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTHGIIFVVDSNDRERVSEAREELQRMLNEDELRDALLLVFANKQDLPNAMNAAEITDKLGLHSLRQRQWFIQATCATSGDGLYEGLEWLSTNLKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQA2</accession>
    <name>W3VQA2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQA2"/>
    <dbReference type="HOGENOM" id="CLU_520918_0_0_1"/>
    <dbReference type="OrthoDB" id="2554395at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="50806" checksum="5614BC88C6F896F2" modified="2014-03-19" version="1">MASPPAQPTVADAVRLMDALRMPSGTALRTTHKITPAATGCLNHSTAATSAASGPGGTTRRSTKPTESGRVPNLPAEIIFQIGTHLAPSRIHTTSSLPCAHTDALPCTATAGVGLSALLGLASASRSFHNTLVPLIWHTLTIRTPQTLPRLSSLLAAYDTMSLRSRLGQEGGLRHPLGHIRSIVVALPDKYAELDQTYLLALLRAMDLPRTRQVEHLAWSAECAPSPALWPLLAKSLRSLEVDGRMFYQGHSGWASLEGLEVLRMTGYDSTLLPKGAVEVIRARADSMLQDLVSEVPKEQVLQRVPRRTAQHLYLDASPTDDPAPAPGPVSTGMSRLRHLSLSSSKTSLLHQASLISAGCFVGLTCLDLYAVTPEPPLSLAILSAAATLTHLRLVLDISGAFGHFDALWTTLTAHLPHLLVLEIDPMPQQNTAPSFGGFVESCPRLRRINGRSLDAFPPCFGDFDPSHPSGALPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQE0</accession>
    <name>W3VQE0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQE0"/>
    <dbReference type="HOGENOM" id="CLU_829297_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="335" mass="35815" checksum="99A68A8EBF0A0B64" modified="2014-03-19" version="1">MGLRRVWSPCAASSGAWLEAHFTFNSTPRRPISRLEGRSPLTTVATDVVDEVCAPTNHPEGVDLDLREAERSTRNPGASIPLMTSTSRRARLGDGAQEDEVEVRGAKERCQDSRAERFVDPNSALDESTQLDVYGIAVVAAPSRPRKVDCRCWVDSDLRASTPTGASLLALVRGVSRQAAPPSMPGAFRNRLAAFHATRAPASNHATASAALAVRVCLLERKRSFEGGIYDAPKRATQGSADSAPQPRFLASHVPQVIFEARHAHDFPTVGLSTGLRRISPSTSPSAEIWVPSPSSKLPFLLNSKFPALPLSALSLTGSQSGIGHDPETISIAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQL1</accession>
    <name>W3VQL1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein beta subunit bpp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQL1"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="349" mass="38296" checksum="D4AC232DE83B7AD0" modified="2014-03-19" version="1">MSVPGADLQERIAAARREADGLKEKIRAKKDQMADTSLRAMANDIEPLPRIVMKPRRTLKGHLAKIYAMHWANDKRHLVSASQDGKLIVWDAYTTNKVHAIPLRSSWVMTCAYAPSGNWVACGGLDNICSIYSLRGRDPNNIKVGRELSAHTGYLSCCRFLNDQQILTSSGDMSCILWDIDSGTRITEFNDHTGDVMSISLSPNPNVFVSGACDAMAKVWDIRSGKAVQTFAGHESDINAVQFFPNGDAFATGSDDASCRLFDLRADRELNTYTHDNILCGITSVGFSVSGRILFAGYDDYTCNVWDTLKGERVGVLAAHENRVSCLGVSTDGMALCTGSWDSRLLVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQS0</accession>
    <name>W3VQS0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQS0"/>
    <dbReference type="HOGENOM" id="CLU_839702_0_0_1"/>
    <dbReference type="OrthoDB" id="10362147at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="331" mass="35806" checksum="7EBA1A3263E40BF9" modified="2014-03-19" version="1">MDGEEHRDGVAEIRTATSTSSTMTSDPPRSLPSRPEAVAEVPHRAPTLQRGGRGRPRGSRGNFRGTIHSDLASTRPYLDGGTTDAAAAVMLPFQGAGRGRGRGQGRVRPSRGTFRGGRGRGSLTPTWSQPHFVPEQPSLAASLPQTRNASEHSDVTDSNNAPQQSATGTFEAEPATVQVFCGPEPEVEQDLPLSDQHDASVVACAESMADLSLSPRVRRSSTGSERPSEHAPGVIDAPFSPPQRWSHEHRHYDVPPWTPFPGPPYDALEPAPFLALGPSRMPPPPPPFTVWLPVPYLVYWGPEPFGAHPMFYDVPMVSLTPFHPKDTFCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQS3</accession>
    <name>W3VQS3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQS3"/>
    <dbReference type="HOGENOM" id="CLU_107716_0_2_1"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="42"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="168" mass="18437" checksum="E673CCAC03187F19" modified="2014-03-19" version="1">MSQAEEHPINQSEWWKVYGEPAVKPGAVSVDDLTAWYETKTPGRDFVVVDVRRSDCEYILPGAINLPAHSLPATLPTLVQMLATVPKLVFHCNSSKGRGTRAAGWVADSFFKMHTAAGATQEQAQTRVEQQVLILTGGINAWTEKHGKRALDTRGQPWDGKSLSTIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR15</accession>
    <name>W3VR15_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR15"/>
    <dbReference type="HOGENOM" id="CLU_029375_3_2_1"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="119"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="374" mass="41170" checksum="FACE53B5AE6C4C99" modified="2014-03-19" version="1">MVAPGSSDLLRCSLYLPLGLLAVYTTFFIALLTPTLQRHFIFLHAVQFPFFPSFSQPHKYGLAPGKTRVLHLDTRDGEKIGVWHVLPEIAYQSLVARDEKMEAGQFDDSLYETAMREYPTVLYLHGNAMHRAAPWRIAAYSALTSRMDVNVVAIDYRGFGDSSGSPSEAGVVEDAHAAYRWMKQQQGWSNQRVTLFGQSLGTGIAAILATQLAEHDEVGVVLMAPYANLRSLVSDFRLGGVLPLLAPVKAIPFHESILDRCMQTRLDTLATLPRFISAPHTGRVVLLHARDDPVIPASHSHRLFGALHGAAKKPAVQSRDMPGFAHIQRFQPSSTADDATVTLIETHFGGHNQLTEGALDLVRLALRLPSHLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR62</accession>
    <name>W3VR62_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR62"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="113"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="264"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="584" mass="62107" checksum="83571324ABF9F859" modified="2014-03-19" version="1">MPAAVAPASTAVAPTSTAVSNGTSKMSSSTSSSSTAWKQIAAAKQQARLDQIPADWRLPSELLATANHTSGADLRSIPTSCGILSADEVAITEAPVAEVLAKLQARTWTSESVTTAFCKRAAIAHQLVNCLTELFFDEAIAAAKEIDRQFAATGKPPGPLAGLPVSLKDNFNLKGKDSNLGFVTWINDPADHDSTLVTLLREQGAVLFCKTATPTAMMIAETVSNANGRTLNPFNTRITPGGSSGGESALLALRGSPLGVGTDIGGSIRIPCSFAGLWGLKPSFGRFPTGKCRSGLAGQEAVLSINGPMCNDADGLEIYAKTVVDTEPWHVDPKCVPIPWTPVSASSLPASLTLLVLTNNGIVTPTPPLQRALTHAVTKLRAAGHTVVEWDASLLASDTELFERGLHFIESFFRAEGGATVHSLMEASGEHEEWVEGLAATDADWGKTVKELWQMQAKRTAWAAELQERMRSLVGGGHFDALVSPVAAECSTTHDAYHHIFYTGCWNLMDMPGVVFPMANLAVDKQLDGADAHFAPKSENERKVWAQYSADELHGLPVCLQVVGQRLREEKTIAVARKIHADTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR66</accession>
    <name>W3VR66_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR66"/>
    <dbReference type="HOGENOM" id="CLU_033734_2_2_1"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="511" mass="55399" checksum="9B9A67878FB6A735" modified="2014-03-19" version="1">MLTTLSSLWTGASVEGHLHHDPSCHVQHDPVAVYLSTFLCVGLIVSYLPQILRIVLNKSSQGFSPWFLLLGATSSASSFLNVVALQWGIIRCCPSVPGLECTESLLGIFQVGLQWLMFATVFVLFLIYYPADQRYERAIALPQREQSDQRVRARARKAARTAAKGRGSQAHATDSTGLLAAPAKSSRSLVGASADDTSSVGSENSDLDSVDSHIAQNYGATSAQANPDDTSSDEAQDEDDLDTESQFLLPNHAADAHHRDVSSSAFSRLVPTFWPMWKAPNGSSSSSSSNNAARPSARSSQSGTRASNLPRDMQRIARERRAKAGQRKLRTRKRRTEEWSLALALAWVVLLHFIFISAITLLLVSSLPAKSFPPPEESSMLRSWSTAVTGLATTALSRPSSRLLVSRWAAFLGGSATLLAAGQYVPQIMHTARSKLVGSLSIPMMCLQVPGSAIFVYSLALQPGTDWSSLAAYVLTGVLQLVLLVLCIAWRFRQRRAGIDDYGRPLASISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRH8</accession>
    <name>W3VRH8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gtp-binding protein ypt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRH8"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_7_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="148" mass="16311" checksum="27D0CD91EF84AA95" modified="2014-03-19" version="1">MVVGWDTAGQERFRTITSSYYRGAHGIIVVYDVTDNDTFSNVKQWLQEIDRYACEGVNKLLVGNKSDLTNKKVVEYATAKEFADQLQIPFLETSAKSATNVEQAFLTMAKQIKDRMGNSTVNNQTGAKSTLKVGQGQNVSQQSNGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRL5</accession>
    <name>W3VRL5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRL5"/>
    <dbReference type="ESTHER" id="psea3-m9mcb7">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_6_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150131" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="569" mass="61208" checksum="534D51ADE37836F7" modified="2014-03-19" version="1">MRLPSVWLLAAAAALRSVVALPADASCFQPTVHLPQGTVKGMVDDSYQLDQFLGIPYAKPPVGDLRFARPQPVDASDALIDASQFGDVCMQPPAGFNMSEDCLNLNVIRPKGVAAGAKLPVLVWIYGGAFFAGSTPAYNASELVARSAQMGKPIVFVAISYRVGPFGFLGGKEIVADGTPNAGLYDQRLALKWVQHNIARFGGDAGRVTIFGQSAGAMSVALQTFAYDGNTHGLFHAAIMDSGGIAPGPLLTPHHPTVQSTFEQLAKGVGCTQAPLLECLRSANASAVQSTAMQLTAKAGGTFPIPGALAFLPLVDYALITDYPSVNLAQGKLADIPVISGNALDEGTLFAQKALNSSADFETWVRSAAVIYNTTYTERALQRVFEVYPDDPVQGSPYPNEGTNTSAATQDVGSRMYPPLESNQYKRSAAFFGDFTFNAHRRTYLHAAVGAARKNSRNVWSFEFRQNDMYPNGTGSALGAYHGSELKYLFIRPDGRQKDPQLEEQMPRSYVSFTYYHDPSRLSSLPWTRYTTGEVLQLKGGNVTTVPDTFRKEAMHALTNPSAAAVFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRN7</accession>
    <name>W3VRN7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRN7"/>
    <dbReference type="HOGENOM" id="CLU_009665_1_0_1"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="237"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="379" mass="42345" checksum="70A2394CE7978CB5" modified="2014-03-19" version="1">MAGPTLTWCLVRFGARVTVVQRSPQLLSQGQNIDLRGTALNIVHRMGILETMCRCTNTEKGTALVDQNNRGFATFHIGESASVLTAKYEILRSDLSNILYQAVVQQPGVDFRFGTTIERVVEKGDFAVRVKLSSGEEEEEYDVLVLADGQWSTLRKQVFGTDDLEAVDKNCCFVYSLLSIRPGSAAQNQQWEAASWSRERSVQVALIQSAFSDVGWKVPRLLRGIDAADDLYFQTTQQIRMAKWHRNRIVCLGDTTYAPTPFTGLGTSLAIDGAYLLAGHLSQLEPGQHPALAFDRYDQQFRPFVVHHAGIPEVHQAPRNGGVLRHGDKQTLPFYLPAIRHQTNAVSKWADESYFAARARMARMSWAVKFPSFPALERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRX3</accession>
    <name>W3VRX3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="1">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_01854</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRX3"/>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_1"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000115">
        <property type="entry name" value="Probable asparagine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="63"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="462"/>
            <end position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="696" mass="77199" checksum="BA28C699BEA0801B" modified="2014-03-19" version="1">MQRSPLPPHIPTVARCHRKPASSAALTLKPSPHVATSSELDQDSHQRKLHYVLERQTSTDKMCGILGCIHHPDAPAYRSKMLSMSRCIRHRGPDWSGCVVTPEDGTKGSILCHERLAIVGISTGAQPLVSTDGKLILAVNGEIYNHRQLRKGLKDQSAEFKTESDCEVILHLYREHGTDFVKMLDGMFSFILLDTTHTPHRVVAARDPIGITTLYQGASYKYPGAIYFSSELKAIHEECDRIRSFPPGHFYDSALPEGKETVRYYTPNWLDTDADGAVIPANPTDLKQIREALEKAVRKRLMSEVPYGVLLSGGLDSSLIASIAARETDKMADLQRKAWEERQARRARGVTTPAGNANGAKLPVGLDEDAENEVENLAAWPRLHSFSIGLPGSPDLLAARKAAQFLGTVHHEYTFTVQEGLDAIADVIFHLETYDVTTVRASTPMYLLSRKIKAMGVKMVLSGEGSDEIFGGYLYFHAAPDKASFHQECVRRVKNLHTADCLRANKSTMAWGLEARVPFLDKAFLDVAMNTDAADKMFSKGSLQEVDADGRPRMEKYILRKAFDVIPDDIEAGGDGTGSMLSASAPKKPYLPEDILWRQKEQFSDGVGYSWIDGIKDHAESSISDEKFQERAKRYPTDTPDTKEAYMIREIFESWFPSDAAASTSVRWIPRADWGCASDPSGRAVKIHESAYSADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS24</accession>
    <name>W3VS24_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS24"/>
    <dbReference type="HOGENOM" id="CLU_538748_0_0_1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="506" mass="54809" checksum="28DCD81265BD4531" modified="2014-03-19" version="1">MVRSTGILESIPTATSDTAPKKRNWTQSEDALLTKLMQNRRGSLDKSGSKSGQTDWVSIAQHFGDRNSKDCRKRWNSSLCPLISRGSWTPAEDKLLQQGMQSHMGQWAKIAKHVGSRTGDQCSSRWRVLSSGADWNEERDRILLDFVIKHGKRWAQVRRLWLPMFTNAECRNRYHRIIRQLSADKRHKTEIETLERVCNGKALGASLSLRDKALPSNASSCAPALASRTTGTKSTNTSSSSNSNRSRGGSCDDDEPALAAAEPGRALVRARRSTNAAMESLVQQIMTDGTARDKLMQLALTIVSCMNSDDDEPSPSHAEVHDDAPQPSRVEAQESEQATLADVEDSTMHDVGDAAVQGVSNAGVLDAVLGSGMSEVDEQAWADVVLGLSDYQAMSTAANELTSVPPEPAVQPTRVVEGVPLLNEASCSRCGFKSCVCSWADLCLLDKCMSTDVHRLGSLDAMCGLSDTNSVSGITSPTTSTLLDPASPSTMRSSSDASSLDSSWWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSD9</accession>
    <name>W3VSD9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02008</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSD9"/>
    <dbReference type="HOGENOM" id="CLU_004869_0_0_1"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="14"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="677"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="969" mass="107097" checksum="F7F0F725CFA7CFDA" modified="2014-03-19" version="1">MDRDFYSFVRLSDLNLNVTFRISSLQGKLDRISRTQLLRQPEARQWGAQQSDYPDLLVECCLFADNKPLSVLVKTAYRPFRNNHQWNEWITLPYKLCDLPLGAQLAFTIYDVASSRSARVIGGTTFPLFSKKGTLKSAQHRLFVWKGARADGSVETATPSKVGEMKDEMGRLEKVIKRHERGDLPRVDWLDKLAYRQVEKVYQAESQSSDRLFLYIDLPRFELPVVFCEAESMLPSATASNGLAPLAGTSMGSNAGPSGLSVAGGGHDVGSAASQAGSPSAGTAASGNPTTAAAAAAAAAAALSTADPNRITSSLFTIFDPEISRSNPVEAKHRRLVRSHRSGPLDRELKPSAEVRDELNEILSYPPTRVLTPSEMDRVWSFRFYLTRDPKGLTKFLKSVVWMDQGEAKQATEILLPMWTEPGLDDALELLGPTFQDARVRSYAVRQLERAEDEELILYLLQLVQALKFEKPLARTTGALAGSATGDFDGDTRRGTSARQTVGSSSNSLSDDAAGQDASGLADFLIRRGLSNPALGNNLYWYLEVECEDPKTGSLFKTVKQHYLDRLGQLPTGAARRETLTRQATLLATLSRRAKELRSNRDARPKKIEKLRALIADPKNGLNRFEPPLMLPLDASVSVSGIVAEKSTIFKSNLFPLRLEFTTVSQTSTTSNSVGPEERSSELPDSITASLIEDDIEDDGLAKGRAGDVGQYTLIFKNGDDLRQDQLVIQLFSLMDRLLRNENLDLKMTPYRVLATGSVDGMVQFVDSLSIAAILSAHQGSLLNFLRAHHPQPTSLSTFGVDAGVFETFIRSCAGYCVVTYLLGVGDRHLDNLLLASDGHFFHVDFGYILGRDPKPFPPPVKVCKEMVDAMGGTQSPHYARFKAFCYTAFTNLRKNANLILNLVALMVDANIPDIRLEPDKAVLKVQDKFLLHLSEDDAIKEFESLLNETSYLSTVFDRLHDMAQYFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSE9</accession>
    <name>W3VSE9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4203 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSE9"/>
    <dbReference type="HOGENOM" id="CLU_020881_0_0_1"/>
    <dbReference type="OrthoDB" id="3364886at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="77607" checksum="247A647D54B1280A" modified="2014-03-19" version="1">MPPQSWARSTAPLLAIRSTDPDTTFQGHDSTDIANALAAHAHNMAEIAKESAASSDVGAASFQGHDSADVANAIQNYVVNHQDEPWPQKFTQPGQSASGVQQTAVDLAASVHAVTAGSDSTIFSLSGHVHDQYWMSILLCIVWIVLGLFMLFFGWASFFWGCKVGTKRSRIDDKAKKPRRFSFLSTGTPLAGGVGGVVVGFLFFSFLTTVITSTICITQAKSVSSTSFFVIWLIPGLLGAALAGHWSLLSRAFTGLLAGACFTLIVTAMFGIHTLIIRAIFISVCTSLITAPLLLPRRSAIHFHLLNICTSLIGVVTFLDGVALFAPPRASSDSWIDLWVLLFALDGSASEASASKKWGTSAFKGFIAAAVLGAVVGFLFEFVFHKHASEDPDMEWNNYLGSFTQRLESRQPADAGDRAGSFEPAPGVWQKLSRAFTPSGQPAAYGNISTGGDLEKSPLTNLPGAASRRQARRARSSKNRGGPAKFEALDKRHSDFDFDSDSDATEYDSDSSLHKLNPRSKAVSAKSMISKADADELADELRPLSASNDSKADALRLPRPPSYRTNSSASGSGSTGSGLSGTTINSSGDPSRVSSPAALSSPTRPSFSRHTTQSPPPPFPTAETQLSGSLNPSVPATPSLVHAITRIQAAQAQARAWYETRQEQTSSGLKSPPSDQKNALGASTSAEETTFKDVQDATARAVSPTVKPENADFQSWWGKEVKGDKRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSI5</accession>
    <name>W3VSI5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00941</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSI5"/>
    <dbReference type="HOGENOM" id="CLU_002833_1_3_1"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="120"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="508" mass="54889" checksum="5669207E661985B3" modified="2014-03-19" version="1">MPILARLKHKLSRRFDEDKSSSSPASSLPPSPTKPAAYSTAAATDAPAATAPATNAPAASQPSSSADPATPVATAPASGAAPVAAPTTPAAPANGDTTPADETTDADGHNFTTNGAVVPRVNLAYFTNWGIYGRKYAPSDVPASQLTHILYAFADVKPDTGECILTDLWADEQLHYAGDSWNDTGNNLYGNFKQFLLMKKQNRALKLMLSIGGWTFGPHFAPMAADAKKRARFVSSAIAILENDGLDGLDIDWEYPANAQQASNFTSLLKELRAGLTAHAAKKQDKVPYLLSIAAPCGADHYKLLEVAKMDQYLDFWNLMAYDFSGAWSTVTGHQANLWNIKGKAPSADDAVNFYINNGVVSHKLVLGIPLYGRGFQNTDGSQKPYNGTGQGTWEAGNWDYKFLPVKGAKEMINTKIAASWSYDSAKREFISYDTPQNVLLKCEYIRNKRLRGAMFWELSGDATKTQGGADRSLVALTAKNMGTLDATLNHISYPFSKWDNVKKGMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSK1</accession>
    <name>W3VSK1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSK1"/>
    <dbReference type="HOGENOM" id="CLU_557908_0_0_1"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="489" mass="54813" checksum="E1465DE5AD807607" modified="2014-03-19" version="1">MPSSLQKRAGNRALRTNPPNANIHLGRWGSDWGYVVFCVMAASLIGLLIWSTKLARNRRTFHYLFIPVLAISSVAWYSMASDLGATPVTVQFRHNSPLGPGSRYPTRQIWFARYIDWTLTTSLLLLSLLLITALPLSVIFITLFFNVLMIVCGLLGALTPTRYKWAYFVSAMPNIIAVPKIIALTLVSSATSARCLHALHSATFCITSLHRVYARLDGSEGFGRAYLTGASLLAVIWPMYAICWGLSEGGNVIGVSEEFIFYGLLDIVSKPLFVFLLLGMLRDCDYGALRLRSGKITESRIEERDRDHAPETRQPEQAKAFEGPTQPGAESGLAPADNQYPASQHRPLSHTSTRPEPTGYLIDQNFPFEEPEDKDIVYIGSNVNLPISLVTFSINDTRTDEEVAADKEYLLRHNDMTYTKIVSDAQILEDFYVKAINLLVHAYDHADFDKLKEICRYLKHRQFDYWPAQGLTFTKISETLAVKLAEAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSP3</accession>
    <name>W3VSP3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_02105</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSP3"/>
    <dbReference type="HOGENOM" id="CLU_009169_2_1_1"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="304"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="369"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="511"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS63787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="705" mass="76061" checksum="143831D05B3A0D53" modified="2014-03-19" version="1">MPPNPYIPWLTRPRMYAYGIVSTLVAVATVGTAFSERSNFYAAVVFLGRSNGCMLVLLNFLLVIALIAGRILQLMYFGQLRRSEVELIGERSWYSLVGTLLAVSIFRDDFSVSFVILFGVLLFLKIFHWLSAERVASIMQSPSVPRIFHVRMVSILTTLLLADLLLVAFSLQMLIVKKIKIGMMVLFTSEFIILTALLFNTIAQYILNCIDMAREEPWEAKSLYVLYVDLAHDVVRLGTHAYFFILLTRLYGIPLSLIHDLYSAGRSCTTKVKALFRYRQALKKMETKYPNASAADLQATDGTCIICREDMVAAEASEATPPNSPAAVTNVTPKKLSCGHIFHFRCLRSWLERQQSCPTCRRMILDDEPEPAASPAQQQQPPPPHGPAGAPDDNGSGLDPSDRATNRAGPSGAGLASTAAHGQRTAAEEEYDTRLQGFLQRLQSDLRKVRDEGNLSAQRASNRAASRSGRSTPRTAAWSPDAVFGGSTSGGVGIARHVPAVSSLAQADEGLGGLWMPPPPSTLYRTGRRPVLPTRTKGAEAEASQEDSKGKGKERQPEADAVVQDDAAEDPIDPREAIRQATLRRFGQSANVTSTESTAASTGTAGMERSPLAMIPLFDPRAIADYDAAHASSLPHPLVVHPHTAGTASTLAGGSDAVVGAGTAVQDQIAALRAIQARIDSVIADLARIAPSALSPPNADASSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSR8</accession>
    <name>W3VSR8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribonuclease NucA/NucB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSR8"/>
    <dbReference type="HOGENOM" id="CLU_1385102_0_0_1"/>
    <dbReference type="OrthoDB" id="3259102at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833360" description="Deoxyribonuclease NucA/NucB domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Deoxyribonuclease NucA/NucB" evidence="3">
        <location>
            <begin position="38"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="217" mass="23001" checksum="0F884D241BC355AD" modified="2014-03-19" version="1">MRAGFFLAGVALLGAASAHAATLTWDCTRVPNICSNDCYAIQCAGKPTTLHRDSANASINRANTACKSPNRCANNPTDSNSCDEYPYASSQEGGAGSVTRCVPSTENSRQGGTLSSFYTANSITDGDAYNVAFASTSGLQYCGGSCTNTGNELIKRSPVVGTQHRPRHFLTDEGHQLTMFERVDSPGSLDSLVGTQTWLAFEERNVTIVSVIPDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VST3</accession>
    <name>W3VST3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VST3"/>
    <dbReference type="HOGENOM" id="CLU_010934_1_1_1"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="198"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="778"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="948" mass="98381" checksum="4E4658DDCF04F819" modified="2014-03-19" version="1">MLFDDSARPDHPQPFPSSIQEADTAAAVSWPRPSNPASSRPSPHSPDCFSSSTSSAPVPQHAASSVPPHITRASSAHPTSLASRSLVATYWTVAATVSRASQVTMDDDVEMDDEQEQEHDAVDDTVYDDPDADNDDMDDVDDDEDGDDDEEDDDGDEDDDDDDDDGDDDDDDDDDNEDADDDNDDASVAASGAGARRSAHEDALSAATYLRKTLLTGGSDGFVRRYDVHATMNGKTMLTQNVRHGFVEGITRGGTLSAFWPHEEHPPTNGIASSSFPSASVAEKDRLVGVVHSLALQQDALWGVSGSESGNIHLYTLRHDPGVARHVFRKHKGAVSALALTEDETGMISGGWDRGVHQWDLNTGQIVRSFPGHAGQISGLSFRPHAPASARSPSPRQLNVSIHPSAAESSSTEKQPQDADDAGDAQRHAEQVKEAPGDAPTGQDADEQVAQSRPGEAQSKAAADSEQGDAGADADAASKSVTADAPAPEASAQDITTSAGDAPPQSAEASHPTTRPEPASDAAATDSAAKSASPGPSEATRVKTEPDPSAPSSSLGGGAADDPTEEELAFEAELNASLGMALDGSGGPRADGTRPDRVTLGANGTTAGGLMVAGADEDLDDDAGDDDLFGGSTPPVSAAKDARESARNGRDESDGDDSLFGDGDEDADGDADADADMDAEADADADEDGDDADGSSDEDMPLAGRAMVKNASSQSTLVAESESVPLSLPSSTVKDVKVSSPTAAVPDAGPKKTLPQPAFGGFSVSSSYSAPISSFSPSVMLSTSLSGQAILWDLRCPSYVTDGEARGVHSLGLPSKVPPWCQSAVFSSDGGSVFVGRRNECVDHWDLRSPKLVNTLRLPSGSGPVYALAAMPNSRHIVCGSYDNVRLWDTADTAQGKVPFKIVAGHHGANLSSVLVDSSCKFLLTASGDRGWMGTSTEAVIIHDIKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSW7</accession>
    <name>W3VSW7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSW7"/>
    <dbReference type="HOGENOM" id="CLU_021703_3_0_1"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="81214" checksum="1F3AA7EAD93BF17C" modified="2014-03-19" version="1">MEVSRWPFGGLDGDSMLSTFGHFASSQAAFFLGAHGATRLSLKNAPEILAASLSRTICTRFARMPEETLSFPPLYCVVGAYRLLHDASLWRPMWAKCSSAAKQAGLAGMVWALLTWPIQRLFVRYFMSASASVTGFSALYTSIVHTADVTDDSLPFTIPLPSLQTFATLMFVLGQVHAIMEFWLRRKLRECRNTAYVQTVRSRGKPADWWGEYVEEFSNPPTQKAIKDAKKQGWYLKLASPLVRFVVLKLFLLPIDFVPLFGMALGAALRSLSYGRQLHTALFEAKRMSPLQIELWITERQTAYRSFGFAAALMERIPLVGMVFSISNRIGAAMWAHDLEKRQQRIRASSLSSDAQQLQEFKTKPTLKKIYKQVQAGEAEGQFNGEGLAVLRAHKGAAMFTHLSFTFPLKLISPAASSRIASLASAKAVAALYIVGYGGGLVSGDSVELDMDVGQGACAVVLTQGSTKVFKTRATAPTRHVSTMHTAGPDATSAARVGVGVGGMTRQVYRYLIRADATLVLLPDPVTCFAAARYDQVQRFDLRSSTSSLVMLDWITPGRTAVCHTPHVRVSALDAFPEAQRGAQMKDYTTPPRLPERWKFDSYRSRNEVRLPSHSTARDVLLLEQHADRDHGPEGVGWTELARRNCPYDTYATLLLAGPDAQPLIDTLSVEFEQIQIRPASVHPAVVWSLSAVEDGPPQLVVVRIAAASAAHVRAWLRARLAPLQSVVGRDLLKQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT14</accession>
    <name>W3VT14_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT14"/>
    <dbReference type="HOGENOM" id="CLU_806802_0_0_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="344" mass="37076" checksum="FA10F6AEFC8B8F45" modified="2014-03-19" version="1">MLPRVMCGGTCCGADVACGVWRVALGSPAEYAICELSYSAGIRVHKTQGQAEFLVGWNSYGAGWRSGLGINPALRGGDCGSVAHTTAKRPQHAPNPRSGQRQPTKPAWVMAEGSVVKLARDGVQRVCKEGVRDRIMVHLCHSAGMSGSEVRALKLSDFLLHADVGSGLRVQVKGRVVGRRKDVELCVVGALALHLYFTDSQGDKVFGSPLEGKPAISPGKTFNGSYLNRPEQVLATSEEGNIQVPAEILDAVFPGRKEGLLHGLCSVLVQDAAVLRRKYPRHALFTPGAISDPAFEAFARRLTAQSSVQGTRLVAFPETSLRLTAREDGLPSLKQEMDRLRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTD1</accession>
    <name>W3VTD1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTD1"/>
    <dbReference type="HOGENOM" id="CLU_019955_2_0_1"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="713" mass="76103" checksum="99366DFA12D7D5E9" modified="2014-03-19" version="1">MPEKVLLVGPVHGRLLELVSKTSAIQAKHGPFAALFIVGDLFASTPTDDAAKQLSDLLAGTLSLPIPTYFYQALGSLPADVGKRISEARPSSSNGLVAVTPQLHWAAGKSGVFTTAQGFRVAFVGGDWDAGAFAADGGLGDFDAEDWHESPTQRAEDEKTTYITPSTVRRLLAHPSFRLPKPSVAEEGSAPAAKEGTLAAARASASAEQARAARQSAALEMLQQRPALDLLLTNTWPAGVTLFATGADADAGLPDPTARTWGSPVIARLATHACARYHFALAPSPDSPDLPVGIQEATLGMGAFWERAPYTTDLASYLPAPVRAPLRSVTRFVSLATFGNSGKRRWFVALNLTPADEQGAAVVPPNATPSPYATPKAAKQAKRAQPAEEEQNFRFGEAGRKRARADGDVPPPGYVCRICGVEGHFIRACPSKTNAQQPASAAEGAGKMELPMGLPSKPSFAQGGRQMIPVGPANCWFCLSNPSVEKQLIVTIGSASYLVRPKGPFVHASVNEIPHTGAHFIVVPLAHVADLLPGSHPVHGGQGDDGEKASIRSEVESTKAAVRAVWAKEGHVMLEWTLVRVRTSPRMTHFQTQLLALKSSIEVAEKLDDALEAQANSAKTAVLRSDAAREYFDQTHTEDRGDDGYLHIKLHAQKEREWLVPLYTGTRFPVQFVRSTLAAALQLPQLADWKACTGEADAEQERHDSAALRAMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTF8</accession>
    <name>W3VTF8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_01327</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTF8"/>
    <dbReference type="HOGENOM" id="CLU_007736_1_0_1"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="202"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="13">
        <location>
            <begin position="444"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="608"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS64092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1093" mass="123574" checksum="0C420CD6D47FA3EB" modified="2014-03-19" version="1">MPAKRRSAPTDDAPVDVVESASKQPELPEAMGPLAALFPLTAVSPDPTTDEALIPLADIKLEQELLRNPDNYRVWTSYIEHIVETNVVKRPPPDVAFTTYQAALLGPLASSTQRIALRRITSIYERALAQFPTRYALWRDYLQHRSRFVMGEPKGGFEAKRKRDLQAAREKLDFGPTLVDSQDDEDFGPAYRGGLDGIVGWQEWKSLAALYERALMWLPTMPRIWLSYLSMFLHPQCPPTLSHTHARRTFDRALRTLPGSLHLRVWKVYLRWAERRGGETCLKVWRRYLRVDPSLTERYVSILLAQTEDQDEEVEGEGEDDDSATTRAKGGVSKALEASKLLLGLARRAADGSYISPDDKSPYQLFTEWLELTEKYPEQIGLDPEEEKQVLEQSLVPLSAAGVSTKDKAAKPASTQKGAKSKASDAPESSSKSLAKQLETDARDPSRLNVTAIIKEDGLERFPDQSGRLWTGLATYWIKRGEFDVASATFEAGMKAVKTVRDFTQIFDAYAETSENVIAFMMDELAEDGGEEEDDEEEPREQKEADLDRRMQEFEELMERRPFLVNDVLLRRNPDDVQEWEKRVVLYGDNDDKIIETYREAIQKINARKATANFHQLFLNFAQFYEYGGSAGLARRSQERAEEAAGEGADVANGEEEEVEGDLESARRIFEKAVTVPFRRVDDLAEVWCEWAEMELRHSNYDGAIRVMARSVAPPKNAKGVQYHDEALAPQTRLFKSLKLWSFYVDLEESLGDVESTKRVYEKMLELKIANAQIMINYAAFLEANEYFEETFKVYERGVELFTYPVAFEIWNVYLSKFIKRYGGTKLERARDLFEQALDKCPARFCKPLMLMYGKLEEEHGLAKRAMKIYERATRAVGSEERFDMFTFYIAKAAANFGLAATRPIYERAIEALPDAQTAEMCVRFAELERKLGEIDRARAIYAHAAQFCDPRTHTEFWKQWNQFEIETGSEDTFREMLRIKRSVQAQFNTDVSYIAASALTQAQRSQAQQATQQDAAGVNGSGGELAQADAAESDDPMARVEAAAAAAARPAGRQPAFVAATTAASGARTENDQNTRNDEVVGGNDDDDDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTJ9</accession>
    <name>W3VTJ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243569_0_0_1"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="953"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1522"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1577" mass="168305" checksum="6DE33D5A8634B378" modified="2014-03-19" version="1">MPADPSPTGSVRSIASSRSGTLSRPPPPPKPSHLSSAFTGTCNSIALRHYIQEHTTGGSGTISKAHLGHGYDTSTVDHFVDAFDSASDDDDGNHDIAARPTVRGRTYTAPSVSRIFDQSTDDNDTFDTARLVRNEPISITGAGPSRVGNLRNLFEAAAPTPSAFVPLSRQNTGVKANHTGTKPKISSHVRMLQAQITGDRFNGMAGAFHVADARSSIILETAANHKQEATEQSQDDYDIYRTATQDLLGDALKMDAVVMPPLSDTICVAQPKPSSSSQAHATVSRSTSLNCDPSAQHDRTESSATIRPSYASKAPASPSKPQVGSPSDPSEVVPSTIRVRPARQANGAAKQGHLSSIFTASPTSSHRGDDHVGSSISPSPSGVSVASNSSSQQDTEAERSREPSMLLADDQDISFSQVSQHLRANDGSCFDLDWGNNSSPSKAASVRRALLSSPAAQTPLEDVDEATIDVNPRREQEKNPEVGEALPQADSARPPSIRVQDQPSSDTPTVQPEGQSEPEASALSARPSSKLQPPRPVSTRGPQSGFGRPARALYDFEGEVAFNELVIKAGQSFEILSDQLAGGWSLGLVWDADGNPTRGLIPQGWYCYIRDFTRSPPPSAGAAPPATPDLVTKNADAQDATLPPSAFLDDRSADNVLEETAASVPQKIEQATSPSGPVDRELALESNEPLSSEVEIAHKSTSPQSARTSAPVSADSSGPSCSRESSRPHTPNSADAALVDADPAAVWQTSEDVHSKLVTEVESSTSIPAVNPTAIDGLPAPSDPDHPIDWSAMAESQVWAEEERISPEHDGRPAVSSPAATPALETTDPSASAGSDWTGSIFGKKTFNRFVSFVTSGAEDFVLSSSDAGEEERSRIMVRKVSGSKSTSGVAALAQVAEEPEGAADLPAGLETKSYESTPALQAQGGAVKSDQSQHFVIAGAAGPKWKSQLPCFLVQVHHPEKRTRLNGMQEYTVYHVTSTYPIDAPDGVSGEQMDSAAQATGTVPYDPLGGPYPPGAQVTVVRRFTQFEWLRLVLTRHYSALLIPPLPEKQYSGRFASDFIETRRADLEMWISRLVRHPVLRYSEPIRFFLSCENENEWRSKAAILLHDGASEGVSKGGVFDNTWHPDFNFDAGEAEVEAERMDAFLKALEKTINGVGGHNAGRQGVLAAYKGHREGNVAISSTYRDLSYTLLRTLTGAGAGPADEGSTSAALLDEDAHRIHGPPMGNVGRRSETGATNEHGAWCWREDCQDCLNLTSALQNTAECLQSVADIYEHHARDALLRQHERYKELSRPHTMAQALLDTHRTTLAKYREATGEAEPWGDDAELDDAVPSNGAHLPREDAEQLAARCETVVNVTMSEMDRVHDERVQDFHALGRSLLDGEIELYEGILEQLKAARLHYDEEYYERESDFHVLASRYQPELSRPKKPAAPLLMPSAAHGPPGGLGRAAGGVGLLLSQATGAGVTRPASIGVECSDRSPLASPRRGELGLSRADLDSGAGRTTGGGLLSTLLVPSVLRGRTAGDGESKPTHLADTTNVQPSHADAALKALARKHAAPPAHDASRSSSYFSAIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTQ6</accession>
    <name>W3VTQ6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTQ6"/>
    <dbReference type="HOGENOM" id="CLU_011781_2_3_1"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000020">
        <property type="entry name" value="Probable aminopeptidase P, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="8">
        <location>
            <begin position="147"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="454"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="9">
        <location>
            <begin position="682"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="745" mass="81309" checksum="1E23E0FFE530A038" modified="2014-03-19" version="1">MIEAQRATLPPHPSSLTPPIKPTSVALPSARSSYMLIAPTPTLAATCKSSLPPLATRITAARHFRASYLHTSGLQALCTLSPLPFSSLVPSHGSLLQSAPNQSGLRFSGPQQHAFGLQHLTRPASTSSTSAATMGAIATGRVDTTQRVQALRELMAKHGVDAYVIPSGDEHASEYPAESDLRRGYITGFTGSAGSAVVTTSKALLFTDGRYFLQAGQQLEPSVWTLMKQGEPNVPTWQEYLSKDLPANSKIGMDASLISADDAKDITAELSKKGSSLVSIRENLVDNVWSDRPTRPGQPIFVLDEKVAGRSSSDKIRELRDEIKKKSAHGFVANMLDETAWLFNLRGTDVPYNPVFFSFALVLLDKVLLYVNDSQLTDEVKASLSSEVTLRPYAEFYNDLHSVGAELGEGNKILIGKSASLAVQEALGGAAKVEIVRSIVGDQKSIKNDVELDGFRQSHIRDGAALCQYFAWLEEQLIAGKKVTESEGADKLSEYRQSLDHFRGESFTTISSTGSNGAIIHYSPDPSSCPAIDVNEIYLCDSGAQFTDGTTDVTRTWHFGEPKAEHIRAFTRVLQGHIAIDRAVFPKGTTGYLLDVLARRALWEDGLDYRHGTGHGVGHFLNVHEGPQGIGTRAVFNETSLKENMVVSNEPGYYEDGKWGIRIENLVIVRPAKTPNNFGSKGYLTFEHLTMCPIQVSLVDPTLLTQDDKNWLNSYHDEVQAKVGPLLQNDQRALAWLKKQCSARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTR4</accession>
    <name>W3VTR4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_00380</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003018_0_1_1"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000057">
        <property type="entry name" value="RAD2p Single-stranded DNA endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="1065"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="944"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1329"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1367"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1412"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="669"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1367"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1412"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1463"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1514"/>
            <end position="1538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS64944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1538" mass="166183" checksum="54C5A39CB3899E28" modified="2014-03-19" version="1">MGVQGLWQLLQPVARPIKIETLEGKRLAIDSSLWLYHFQMAMRDKEGRTLSNAHILGFLWRILKLLFHGVRPVFVFDGGAPVMKRKTLSGRKARKQGAKESHARTAEKLLNAQMRQAAIKHVAEAGGAPPRASSSTDNNADASAGASGLGENTVYYDDLQAGRPSALSSRDLHSGASPSSAPQSRENSSSPSKPGARKVDWHKDPYALPAMEKDLNQVAAANGRKGKRKDYRFATEAELRAVMNTIAPEDLDTTSELFRSLPPELQYELVGDLRAQSRMTSYKRLQSMLATAPTPIDFSRAQIAGLKTRNDLTQKVLTVTDEIGNANIKVPIRVAGERNKEYVLVRNPGAEGGFVLGVRDSGTTQDKAIDVDYEPEEINITDDEHNHTDSEPEIEMDDVEIPASVSPSRKASAAADPEMAELQKEADPHVRKEKALELLQARARQHAKQRRREAGLADADDGLERDLRPHRKRGERPLFIRNPRTATSGSSQSPQNEWIDVDADSDADDDFSIAEAVDDELEEDEAEDLARAIAESQAAQSGSEQHRAGLKLAHRSGEPVSLHDAMLHRGDSVQARPHVAPPATAPLEVADQAALDVDELNDDDFEDVQPEPLSALQEVEPGFAAQPTAVSDGTDADHSGRMQELAALANRHRRKPVDAVQAPPPPPRKSLAGSLRAARRTASSSAQPSIVVADDEPQAPVPAPEKSSEPPSRSARMGPPLRSASQQRLELANLAPSTSAAVEMAHDDLPPTPEEVNRQIAIEARSDVQEVGEQPQPREGVDTPPRPELVEQASPAHATSEAVEMGHDELPPTPEEVNRQIAVEARSDEAEEHASTIRDEPQPHKSALDAPPAPEVVELEPEQPSVDTVLPMADDVESNPAAEDAAGRGEAAGLEDVEETGVPVSLSVPEQASAVAQGVPHPDAGGAADDVAMDNIPAAAAEQTESVLQDNGPTNLDERQTTPVEWSPTPSPEPEEVVIGADGFPLPTAAELDALSASDDDIARLSADQSEFVAFLSATKGRSLLDVQQQVESEVNALRAEFANSRRSEEDITKQMAQEIQMMLRLFGLPYITAPMEAEAQCAELVSRRLVDGIITDDSDVFLFGGTRIYKNMFNNNRIVECFLLSDMQRELGLDREKLVRLAYYLGSDYTEGLAGVGPVVAMELLALFPGEDGLLKFREWWMRVQTGADTHEHTRGKTMRRIKKNLRNKVHLEPSWPEPAVLDAYYAPTVDESDEPFAWGLPDLDSLRTFLGEYLHWPVSKTDQYVLPIIERQNARTRARGNQTTLDRGGFFDTSAGTGVYAGRRKITYGSNRLQEVINGFRAVNGKKAAPVRTARRGSADTSSGSDDDVQVVGARLATPAVAEEMLGKEMAKKRPVVRRDEAGASANEEQTSAARTAELDAAIEALEGPSAAVEAGSSGAKAVAAGREKRKKRGAREEDALSSSASSGKGEVQLEPVSKAARGRGRGRGRARARGGRGGRGGRGRTTLHAARNMSLDDIDTLPPSRSPSVDAASLRARAAGARRSSTASSRSTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUH6</accession>
    <name>W3VUH6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUH6"/>
    <dbReference type="HOGENOM" id="CLU_328170_0_0_1"/>
    <dbReference type="OrthoDB" id="266663at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="731"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="854" mass="92098" checksum="345B56615432CD03" modified="2014-03-19" version="1">MAQPVVQQPTLSPPLSPSAHIITSVVPSPVTDFGSKPLTFPHRPPAPASSTSSQTHNNNNNNSRPTKENGANRSRQSRSRPTSSSGKAHSQHAGATFQNGKANGVANAVHTAATNGHAIGHSHRTHSNGVDAANDPSIANAPGAALSIATKPQDRDPSLLRQPPQSKGFDGISSYQLDHNGRIPASEYNYLQRDKLVASAHRSAISAGNYHWLALMDLSHLASQHHLSPYSVMKFGPRGSPFAYIPITLQQPDVVHTTMMRQRVEERQAKAWLIAKRRRKVAAAHSDDEDLPVLRLPADVFKKPSHPAQPRDASTAPAQLGTKRPASFTTPPDTRARCVLRTDADIDGSELKQVERDLGEAMAESISATAAPEPASSSEEDEVAPVSRSDQVDLSRFDRSTRMAENGSAAPETSRTNGGTQPNAQGNQGANKDTVADELMTSSEAGSNVEVGGPLDKERVMAQEMESVDTTAPKPGHVDERAPAVTDNSSLGPLVHMTGNGSGPASSLAESSSAEQQQQQQQQQPQNQLAMKTSDTHPIHISPILPDELLPEVGRRIRALAEPQLRALRADSAAAGTAATERYFDDHAHEQVHCGRLIRLHHMLDLAAVTATDPSANYLSQSQLAEQAARENTQALNTIPGENDEGSVGNLLLSSCPGKKVRLSGPVRGRGAICRDLGLDLARIHSIGYEREADRLGLDVFRLPMAEGFAPTKVAEMDAAMTAIVTDCTLRGTNVLVHCRGGVGRAGLIACAWLLKMGFVADKPPRPKKKAEEARKFLPHAHELDDKPRKARASEVDDADDDAETILETVRSLIETIRRRRSPKAIETAEQVRFLVDYLTYLHRQERLRAQAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUI1</accession>
    <name>W3VUI1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Helicase SWR1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Helicase swr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PaG_00227</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_24_3_1"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.850:FF:000009">
        <property type="entry name" value="SNF2 family helicase/ATPase (Swr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="22">
        <location>
            <begin position="692"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="1149"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="1669"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="109"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="211"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="466"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="822"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1879"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="844"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="932"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="950"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="975"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1049"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1904"/>
            <end position="1913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ETS65165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1930" mass="215061" checksum="D3EF960E7D4DB46A" modified="2014-03-19" version="1">MFPKQHPLFPSASDPFPPTTSSFLSRDHSSERLHFPLCGPSHLHGTAADRLIHHRSHRASVRAHNNKVGSPPSLADSAPSRRVRGVAQHTSVGADHAAEAEELLLRASGAAASASRQNGPTFMSTGGTHSHHAETSSSNLSGSHHSGAENGHDAPAAGTNGDASHAETSRQGSTSGERSVSPRNEATPAAPVKRKRLAAELAFSSPGPAFQLQKDAEADEQLTSDTPGRARRPRRSTTLNGGGTSSLTSNRRASQSRPQQVSASLRDEEPFDAKPRLTPTISPKPYANEADLDAPNETTRIGTEAGPIASTSSSRSDRSRSRSRSAFQQDESETQSFSDQGQAESPAKPPLPLRTRPQITPIAAHDAATPLPQILERRRHEKVAVAQSDLEEVHDRHDMLVRELFHLTKFVTMVGYDPDEARNDQSDVFTTFKHAHDLRFSLDDAGSGAEASGSGRVTRRRVNARLESLSLKRPPPPTSPATRATSAKNGSKRRSSDRFPGRASSSTAEPEARGSTADASEGATSDDNSQDEDDISDMSDSQAASRRAGKQKSSRGRSKGKQKQSRTTAPSRKRQSSFADDSFDTPAKRSSGARKSKALDELDAFILRHQPRPLPEQAPPLHILAPHQVPALKRFGGDINALWTSFDLLRDGEGGRDPAEVEAEDLQTYLRRDQRWRAGLPIHPESGGIARHVPAKAARTTKSHHDHLLDAVAASYQPMRQYAKSRQQNARRVARMVAQHWERQLGSSEREKKAEEKRIRALAKWTLREVLKQWRLAVNVVRARKAAAEKAEKEKLDKEQLNAILEQSTAMLKKQHQVMTTNADGFSDSDMDGNSDRTSYGSDDSTEAAESEDEASDADPDADVDEGIDARDGSEPATVEALPATIAEVDAIDDATSATGASTPAAAETQPSPVHAPASSRPQRSSRRTRGAARPTAAQQARAAAKLEADDVEFAVAEADDAEEEDAELERQMWEEDEEDDSEDAGLAADANIPIEELLKRYGYGASPEEAESEDNDNQADAGASTANQSDREPDEQMPDVEDVKGEEATDDDKDTEASDEETPTREDRSASLALLRQADESADELSDAESVATGGRRGSRRSMTRASSIVSSDRAVTRSRQPFLLRGQLRPYQQIGFEWLASLYANGMGLGKTIQTISLLAHLACDKGVWGPHLVVAPTSVMLNWEVEFKKFLPGFKILSYYGNQKERKEKRIGWNTENSFNVCITSYQLVLADQHIFRRKPWVYLVLDEAHHIKNFRSQRWQTLLGFNSQRRLLLTGTPLQNNLMDLWSLMYFLMPHGVSELPGGGAFANMKDFQDWFSNPLDKAIEGGNSMSDETRAMVQKLHAVLRPYLLRRLKSEVEKELPSKYEHVITCRLSKRQRFLYNDFMSRAKTRESLASGNYLSIINCLMQLRKVCNHPDLFEVRPIVTSFAMSRSVVADFEIKDLLVRRELLREDVWDKVDLDATNFRFTDREEHLTAIESRDLRRLNAAKKLPYFGDAVAELPELETWTIDGFAKSREQRRLVGEMERWKHAAYINQYRCTKRPVYGAALIRMLREAGRSARLEPAEQHEGDRRGYLDRCDNLLRMVQSRSTRRENMQPVIDRFAFVTPRAVAVDMPRWALAGFEPYQQPEMVKPEFDTVHPVAVKLHIAFPDASLLQYDCGKLQQLDLLMRRLKDGGHRILIFTQMTRVLDILESFLNYHGYRYLRLDGATKVEQRQALTEKFNRDLRISAFILSTRSGGLGINLTGADTVLFYDLDWNAAIEAQCMDRAHRIGQTRDVHIYRFVTEHTIEENMLRKANQKRLLDSVVIQQGEFNTETLAKRIDWRDMLDDGGRLGDVEVKVDESGETGREVERAFLDAEDEEDRQAALAARQEMVDEDEFDEPQVPVQADAEAGPVIPPEEDEEEGGTVDDYMLGFVEREWDFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV59</accession>
    <name>W3VV59_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HypA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV59"/>
    <dbReference type="HOGENOM" id="CLU_019145_1_0_1"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="50335" checksum="B537FD081DA41CF2" modified="2014-03-19" version="1">MSFEASTAFGALSPLVRDDSRRELSSLLATNHASYHCFFNTRGMHNHLVHQLIADVTLGATPADLRSHMQYQRDHYLGGFSLSRRERYDPHTTDSAAVPKITDANWGDHLGRPSHYWTYLHFFEHKLQDLGMARVLEEYVFSAGANQAGREMLARWLGGVLHAAIHFGYAVETRVVGVAAEAMAMAAVTAARHTWLTPHDWLMQTPRAGKSLLELVREVQSDARVAVDALGLREADTPLIDEPFEKGGRAYGVVHEYIDAWNVNDIGQASSEVALLAALMLGAVPLKDGAYHHDFFLMHVNNVHLFTPLLLELLPASSRGAMLRALGAHLLYYYIVRGRPAFTPSHLTNPLCTRKLGWDEMFKASRESVDEHLPKAVRTLYIHSLAHPPPPHRGQLNTLLALSHDDTTLDDVYRATAQQMVDMHTGQIRPSTHDVMGAQQEFWQFQPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVB0</accession>
    <name>W3VVB0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">signal-recognition-particle GTPase</fullName>
            <ecNumber evidence="11">3.6.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Signal recognition particle 54 kDa protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00684</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVB0"/>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000001">
        <property type="entry name" value="Signal recognition particle GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="645" mass="68598" checksum="337B23E66930C063" modified="2014-03-19" version="1">MVLSDLGRRINSAFQDLSKVPTVDAASIDQLLKSVCNALIEADVNVKLVANLRSQVKSQVTALLNDKANANWSDAQRRQRVQKAVFDHLVALVDPLHGQSTTDDESGAVVPSANAGPGDIFKPKKGKPNVIMFVGLQGSGKTTSCTKLALYYQKRGFKTGLVCADTFRAGAFDQLKQNASKINVPFYGSYTETDPVAISAAGVASFKQNRFEVIIVDTSGRHKQEQELFDEMREIDAAVTPDLTIMVLDANIGQAAEAQSRAFKDAAGYGAIIVTKLDGHAKGGGAISAVAATKTPIMFIGTGEHAADLEPFRAQPFISKLLGMGDITGLMDKMEEMQMNGGQERQREMLKKIEEGGIFSIRDWREQLSNIMGMGPLSKIAGMIPGMGQMLSGAGGDDEAAGGKMKRMMFITDAMTAEELDSDGRLFYAPIRSKKPPAPADTKEVAIAESSTAAAKSKKKKKPQQKVRMTARARRVARGSGTSVKEVEEFLMQYRLVSSMVKKMGGKQGWLKQMQGLGGGGKGKMPAPGQLPPGMSREQVMQMQNALPPEIKAQLRQPGGREKLLQQIQSGNIPEGLAGLGGMGGLGGMGGMGGMPGLGGLANMMGGGGMPDMAQMQKMMQSMGGGGMMNMMKGLMGGATPPPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX80</accession>
    <name>W3VX80_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX80"/>
    <dbReference type="HOGENOM" id="CLU_041823_0_0_1"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="166"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="472" mass="51541" checksum="FC8C5FA861FB917B" modified="2014-03-19" version="1">MRKAKVFSHETVMPRMSWSARNLYNMIARSTVPFHASQTSFTKTSLTMYQQRWRSKRFLRAYHGDWIPEKRFKRWFLPTELPSFVPPQVSAATASGVSSGSSTSGPRRGGLFDKALQARRAPAAPAAGAPSASGSGSSYATVTQQKALEEMDAMPTASLFMRDIERRLDVVVFRSCFARSAYESRAMVVQGKVKINGTRCSNPNQLLQPGDLISVEPSAVPMLSEELAKKAKQQRINDAVSGEADATEAAQASEAAEASAESAPAPEAKEGEAAAESADASTQASTEAEASSENAGDKADASAARADKGKDKEKEKMLPPGVRPFTLPDYAAPFLFVPPYLEVSFATCSAIYVRHPTIVPYKTVGADGKQRWTFRTDLPSPYPAGGELYSMAWEHYTRNAPRTRADARRTKLEARVGRNGFESQRAKDQNSKRSALRRGWGRTKPVSGWRKHLAAAQARQESHTQSAARIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VCZ2</accession>
    <name>W3VCZ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VCZ2"/>
    <dbReference type="HOGENOM" id="CLU_024413_0_0_1"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="249"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="490" mass="51929" checksum="015661B08DD94F1D" modified="2014-03-19" version="1">MAKGSSIWTDQLVSLLGLDNETVRTQILPFLDSFDTEPALRSHLQGLVGDDSPLARSFVRDFARSRFPQQASSGSSTPTLPAPSSSASSGAPRKRGKKTLAERAGLGQTLEPRKVQDAGLNEEEQMAKLAEAFGGMGTVYRKKNDDEDFFTGTGKGKKRGQPASKADSAHEPGPATQPDTSASAVIDATPPNEAMHTATAVDEETSAAVHRSQPAPPPTAAMAAIDAVVEELTLDPPSLPGAGSDEVVRKMCFCQGRKHALAPHAPLCYACGLVLCSAILPSPLSPASRCPSCAASPLLSEAARSDLVAKLTAEREVLFEQQQLQIALQREQKKLNKTAARSAREQEAALFPKLGDQPVATASASSTAPVIGKHGSLQKARAIAGEAERTAKVLSLDMKTHKLKTHTKLAKPKAAAAAITKAVETKVEEEQDPFVGMDGAPLVRNEKDDGMHAPPRRRRVSSNGVGRRIPPRAWVLAGESVRLRPTPSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDC2</accession>
    <name>W3VDC2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear protein bimA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDC2"/>
    <dbReference type="HOGENOM" id="CLU_277212_0_0_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="721"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="524"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="589"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1201" mass="125706" checksum="D53F32599D4039B7" modified="2014-03-19" version="1">MPLASTNAKARLAATKTRQPIASTSASTSASASAHPTAASIRSRVPPSGHAALHDAALSQPQPSRPLQLQLPPPLPTIVDLQTANKIAPSSQVVSARLLSLARSFLAIHPDTGSPDPLDWELDLCTATFFAVYAVCLDPASTLARRTLARCARLGGFNIVLPFAPAGSAASSIVSPSTLSSHDPHDVPGAHACIHILQQGSAATFQDPDSAREYRDANRILGRASDAADVLSILNDKVLGKRKASDTKAELTSTAQPVPAHARFASQLQTDVAHAAYARNRVDEARATFVHAVEQDPFNWRAWAGLCDTGYGSGSASRHLGLSALDRLYSKIVVDVQAPYVSMEAALKSAPAFSAGGHASSSAMVRKVSEDGSNKKFKVSSEAPPVPPLPTNDNRTAPSSAKPTGNLTPPLPTTSASSVTATRLHPPSRALSAAQTNTHHLDPLPSEQDAVKASKVNTVISRPTRNGAVRTATITDGTTTQNGRQLRSTAQRTGPTAAPANVAARARPVSAVQGRAGAISQAGSVSSTSSASSASSMTSRATASTARTAVSTRRAATATTSQPSSRVGLAKSTVPASARSDTAVNGSGAATRRVPTATAARSAPASLSRPGSAMSKASSTSISGPSTAARANGSLASARTAADAMRQKEEETARAKLDELVSLRESCVQRLTALAHQHAADRYILALLAHVGEAYRLLRLCEGDKAAAALMQNVLPSIGAAGQNKNPVVEQRAPTDGQQDDDADELSSITATSEATRLLDLQVKDSLIHHLLLGRSYAESAQYASAETHFAAARKLNPFVASHTDIYSLVLFHLSREVQLSALAQHLVMVAPGTAATHIVVGNAFSLQKEHQTALVCFQRAAAAAPDYAYAYTLAGHEAHDLGLHDEAIAYFRSAIRCDRRHWNAWAGLGRVYLGIGEHEHAACKSLQQAISINPTNHLLWDLVGWTFALVSAPAKALECYNRAIELAPAASVLTYLRRAELLLQQGDVEASHRDLACAHDLAPEEASIHILLAQSYMRLGGGAFCHLETSGGAGQGGVKSGSALRASGVMVLPKAYHAEISHHLSVAVDLDPSLLRVVKSICEGYKNLPGSKLSVHAHDLTAASFTQSHLSADSAGLSHYDASGAESDARHADSNAHHSAYGSFRQHNSLLANSTPQHPQLLVPADFASTHPAAYPDSSSFLSLQTPGSTSDIVLEDADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDZ8</accession>
    <name>W3VDZ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDZ8"/>
    <dbReference type="HOGENOM" id="CLU_007169_0_0_1"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="43"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1118" mass="122920" checksum="4DD16EC85A46EA39" modified="2014-03-19" version="1">MDGLHHLVPRGLYDEPVLPAGINTANLTAVAEYYVSHRIPQRFNPGIVVASIAVSALGSYSTLLVLGKRTSNKGLKNIFLLSLAATTMAAVGIWGMHFIGMHMSLRPVANVSWYIKVDPGFTVLSLFVPIIALHAAFFIVDAAVAFSFVRTAISGVLTGLIVSLMHYSASLKTSYAVIYSPTLVTISIVVACVAATVALTGFFKFRSQWEDSWWKRMLCAFLLASAVSGMHYIGVWGTSYKVKPSTISGSDEISLLTGRQRNNVLVIAIGCMCFVIICFCIFIGVSDMLVVRDARRKSKKVVVCSATFDKQGRLLVKPDGTMPLQIIETDVNTRDILDALDNRQPTFQWLYSLSWDWGIISPWLRAITSRFAAESQNAQRNDALWKNRGKKMIAQGRRSLDLGEERRKGPQSLADFRDRFVDAAVHLAHELDIPFEEIGVLYDHVLPTGTRSKNGGAGNMNAAIHDKFTPSRQFADDESSINGPVPSIFGEGNDQEEGAMLFLVRELPNSAASTERFRQMGYRMTETRFLAGVLADRVAVQKEEMEPLLDSLKVYAKRGTRPVVQPGGVYCGLFGVRASTSKEGGLDVLVYNFARHQIPAYRLPDVQCITPEMKTFLGSLDQATMEDAMKVCERESIRSGERRKYLQSISSVNVADNHENEAEQEAVELMIQFQTALFIALDALHNSVRFYPKICQTARISAEVLEVPSSLDDSTPPAEMILVQAVLPEARSMHTSYGASEGQHVASEVVPTDKPSAATPFVFVPYTLFSKSQMMLLRGRQADDFEHEVILEMRRRYPSSLQSEAEEKGMFGDAAPHRISHKESFISHAGRFAKGYAGSDDDDKLETASKFSDDKDVASPAANKVNLLPSGKRWANRRGSREEGYEYEQPRNADHSTALSPGRRQSVTSSRSRATNEDHEMRQLNDGPLARADSVLRKNAEAGAGNSSLGIRRFIQQPGNEGTSPDGRFVHPVDDAITEEARDADLRSVSSIDVAEKETAYPPASGASPYMPQSNVRALNEASAAAFGQSRPAARPSTAPANVIRRELNFLRPSSSGAGQSQQQQRAGTGHRQRRNRTAVGHDEGSQIARIQSDGWHTRQIQSLERSPAGTALLGVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEA4</accession>
    <name>W3VEA4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEA4"/>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_1"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="98"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="9">
        <location>
            <begin position="276"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="339" mass="36260" checksum="5B3F634AD7BCD8B9" modified="2014-03-19" version="1">MSQSVQDPAQLGEEDMGEGFGPLPVSKLEDFGISSSDCKKLAEAGYNTVESIAFTPKKNLLLVKGISEAKADKILAEAAKLVPMGFTTATEFHARRNELISITTGSKNLDAILGGGMETGSITELYGEFRTGKSQLCHTLAVTCQLPVDMGGGEGKCLYIDTEGTFRPTRLLAVAERYGLNGEEVLDNVAYARAYNADHQLQLLMQASAMMAESRFSLLIVDSLTSLYRTDFSGRGELSARQMHLAKFLRGLMRLADEFGVAVVITNQVVAQVDGATAFTADAKKPIGGNIVAHASTTRLSLRKGRGNQRICRVADSPCLPEADAVFAIGAEGIIDPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEI6</accession>
    <name>W3VEI6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEI6"/>
    <dbReference type="HOGENOM" id="CLU_022332_0_0_1"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="64"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="355" mass="37662" checksum="980F7F3093A40F84" modified="2014-03-19" version="1">MSKDHTALPMQSLSIDEKAGHDPITGHRTPSVGTPGHSGMGAQPTGGILPGGAPKNDKKKIHPAVIIVLWIALSSSVIVYNKFVLDPNQLNFPFPVFLTTFHMAFATVGTRLLARYTHLLDGLANVEMTNERWIKNILPIGALFSCSLIFSNMAYLTLGVSFIQMLKAFTPVAVLLISFAFGLKQLSGSLTMIVGCISFGVALASYGQGDFAMSGFICQVLAIAFESSRLVMIQVLLQGLKMDPLVSLYYFAPVCAAINACVLPFTEGLLPFFQISNLGPFVLFTNAGVAFGLNIAAVFLIGAASSLTLTLAGVIKDILLILGSMLLLGDTVTGLQFVGYGIALAGLVAFKTHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEJ4</accession>
    <name>W3VEJ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_06062</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEJ4"/>
    <dbReference type="HOGENOM" id="CLU_033744_0_0_1"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="655"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="655"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="693" mass="77365" checksum="01480218476C9671" modified="2014-03-19" version="1">MQKGKTTESQLENNVEAKRASPRSEPLHHSLSETFPQPTREVPKKNQLARSVQSESQRRSTTTTTTTTTLTPLPFPEAGSFHAMSSTPPSTSAASSSTSSAPSPAPAPAAGTATGTTAGNTAKPKLPPREVPPILRPLEFVGIPKSVLAWKPRLPSRNWSIFLVTVGTLSYLYYDDRRQCRLIRQDYIDKVSHLSKEPMKPGEWPRKITVYATRSPGDDDYDKALRYFKKYVKPVLVAAGIDWEVTNGTRHGGLARELQSKIHERRRKLLGLEPWMDEITALSQNPFSLTPQQELQREIDGGLVLVGRPALKEWAWALKNGWCTPLEVLKRDRDDELARELAEDHAFDELPAEPSASASSSSAASAPSEFLDEKDRAIAALAETGEEDGAGAPLPSRFGNNRFGSAPYGLGSGPNAFSGVMGPSPAAQAQAEKQRVKSEAEAVAARLDPKLLEVPAQIPAQPPICFVDFTNLVGWRNIPLRMYQFFRQRDKVQHGAELALTLVYGTKESAREFQPGREGTFAGEVSDTPPQGGDLDWGIESEQRYPPYFLKSDKNLAEARESYYKALPKHLKDARDLARGLREPSKIEKNDPSKTESELREERFKKEKEWRNAEMGFEIIRPSAGVAWDERFRGSLRVLTLSDETKVQINRQQKLRNEAQKNAEQRRAAEDKQLREEQAQRQRELESQPLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEL1</accession>
    <name>W3VEL1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEL1"/>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834075" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="565"/>
            <end position="566"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="610"/>
            <end position="611"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="630" mass="68019" checksum="A93A19F8E6A2441E" modified="2014-03-19" version="1">MPRLLLPLTAVLGFIVSLGSVQPHPVQDDPLQRRLLPTPPTTDTYDYIVVGGGTSGMTLAARLSENKAVTVAVLEAGIDYRSSPVNQQLVDTPGFDVFGVGSSPSDFANGLIDWGFVTEGEPGYDNRKVRYARGKCIGGSSARNFMLYHRPPKGAQQTWVDLTGDSQWSFDNTLPYYQKTFTAFGPRSEFRKDNPPAQYNPAAFPGSGPVSVGFPNYAQPFSGPLLNSLNEVGVPTTNDMSSGNILGAQYSTLTVEKSNGKRATSRSFYQQAQNDKRSNLNVIFQALAKKVTFDTSGARPKAVAVDYTLPFGVKGTLKARKEIIISAGAFQSPQLLMVSGVGPADQLRAQNIPIIVENSNVGQHMQDHVFFGPTYSVNVDTPTKEANDPIFLASSIADFNLNNQGIFTNNVADLIAFEKWNGTYLDTIRAGALKSLPSDWPQIEYLSGPGFIGDFSNLVANNIVNGLTLQQFASLLVAIVAPVSEGSVTLKSADTQDLPAIRPNWLSSPVDQQVAIAAFKRTRQVFNANAMKSTRTSSTESFPGLDVATDDQILASIRKNLMTVWHAASTCRMAKDKQSGVLDSNFRVFGVDGLRVVDASAFPRLLPGHPQAVCYMIAERAADIIAAANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VER6</accession>
    <name>W3VER6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rad51-associated protein brh2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VER6"/>
    <dbReference type="HOGENOM" id="CLU_287011_0_0_1"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCA2 OB1" evidence="6">
        <location>
            <begin position="885"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1276" mass="137682" checksum="7DBF7DDE15A55910" modified="2014-03-19" version="1">MRATAGRPPITKCTFSMPFESESAGSEQAVSQHILPEPSRISALFSRQPSNSSAADRGDHPSRSRDACWSPGTASPRATQGMAAVWRLSDADVSRGESGAPHGSQKVLDPPALLRVAPQLREEPTDTLKGRAPASLFLTAVLSRHLYHRPFRCSKAEHVSSADLPPSTDARASTPNAQQNAEPVWIGQAPALLIFAPACQLQPHDPGKLSSIRIERATASDTTMSGLDGLATAQIAPTLEDELAATQQSLLEELHTISEEGILDHNQRDSKAGEANAAEHSDALTSQTLTEHQAAAPAEELEQTSCSAASQNGILPSQQAEVGLETVQTCLQQGNGVETAASDALLHSGDAQVESVVQANTAAPEPKSAQVQQDRKADVVALVQTTDGTAEQSNDASLPATHDAAMETATTTMDISTDILLDHDHLFDGIEADVFGDIELSPPVRRHVSLPQVGVPSQIRSMHAPPSPTRPSQSKASQTAAGRIRGALEDDPFFPEPSEAEAGQTTSCFEPSFAGFKTGHGKKVQLSEKALEVARKLLLDLEESQELLPPPRTSQALSQPSQSQQSPSRAPPARAAHLAARTPMQEVPSKQNVPAVESREVPPPLKSAPGPSQTTGTAVGSSRQIDRPAVATPQPFRSAHLVGSLTPGTPLRISGSASLARFTTPQPTKKVSLGVLPRVGMSASSSRKRPVPRFVTPFKAGKRPKAEELADASSPVRRLDYGTVGASTPTFSSARQYPATRSTRPVNPVNPDAVSVFRLQSAAPRQRLADVGRPEQYSSMQLIARGVPDEIIVILNDASRGAQYAFEGPDGSLLQQQDALDELVARGCSGAKLPWVQNHWTLILWKLAAMVRLDPSCAHERWSWHELIRQLLYRYEREVHLAQRSCLKRIQEHDSSPSRPMVLLVAKILEEETEVQDRSGQVVVRKETILELSDGWYRVQAQVDGVLAQACQRGRLRVGHKLAVMGATLDAQGEGNEVLAAYHLSTLVLSGNSTSLASWDARLGFAPQPFFASLRSLTPEGGVVSLMDVVITKVFPLAYVDAERTTDRSAAPRGEQEEAEQLEAWKQRREDAMAQLELQLESEQRRLYDLVEAIGDLASDAFLPSLPEDPSGRLEAVAATLFDQLQARPNPAQAVKELVIQPGHASTVPWLHSMAKAALVAQDGGAARLGAHLDRLCPPRKVRGFRVVRFRDARLPEPPAPPATNAGAAGKKRNAHARTVQLTVWDAVQLGDELQEGRRFWVTNLVPTSKTAWRKPDEAADVFLATRRDTKWRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VET8</accession>
    <name>W3VET8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VET8"/>
    <dbReference type="HOGENOM" id="CLU_000288_5_12_1"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="347"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="685" mass="76172" checksum="B1A831CBA40C98A8" modified="2014-03-19" version="1">MATVVPRAKKQRTIPEDHLDHANLSLQAADPTHPSMLAHQHPIPPAHHQHQQQQYQYATATHNPAMSNSAPSGSRPARPASGFQRVNEVIGGKVQEVFVIDDDTPPPSNPLSVQAARDPHLVNNYAHLNGHAAAPAAYASDLHPYASDPRYNQAASLSKGKRKANDNGVHPALASSHLGMLPHDADLIAPAPHTTLQPVPADAPVQKRRKRSHPVRPDGTTSGATSYDPSDPSHAAAAHLAASGVAGLAQANRHAPEMVQTRVPSNYRGGYPASSGTLDYLARYDPTNANAAFAQARQAYEGSAASTRDSYASSASYVAAVAAHSGPVDDDQGHFLVKEGDYVTSRYKILRLLGQGTFGKVVECYDKKQRKYVAIKIIRAVQKYRDASQIEIRVLRALRENDPHNENKCIHLLETFNFKNHVCIVSELLGKSVFDFLKENKFQPFPPLHIWQFAKQLMQSVAFLHRLNLVHTDLKPENILLISSEHSIVATSRRQNAKRKHVLHNTEIRLIDFGSATFNDEFHSSVVSTRHYRAPEIILSMGWSFPCDVWSIGCILVEFFTGDALFQTHDNLEHLAMMEAVLGKMPDDYRRKAETYKPEYFKNGALRYPVAETSKDSRKYVRQMKKLHDLINTPATQSAYAKHNSRFLSLLRQLLEFDAAKRIKVADALKHPYFDLDPEKDFPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFJ0</accession>
    <name>W3VFJ0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFJ0"/>
    <dbReference type="HOGENOM" id="CLU_872025_0_0_1"/>
    <dbReference type="OrthoDB" id="2555737at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="326" mass="33964" checksum="A003F65E782E93AD" modified="2014-03-19" version="1">MMHTSLTRGAMPMRGVVRSFTSSAQVYAEGAPATSTPRPRSSPRSSQPDARPARAGGNAADRLRNGERSRNSARANGQASNRNAGGDRRNKRLPSVFDGSSPARAERAPRGVMLKGRDQQSQRMAAPKTTTDWNSPLYAKPGYERFLPSAPRASSIFTPNLSAAAAATPAAGGKGKGKAAAAPASTPQAKLNLPGIKAAVNALKLHIRPGGRNILGPTHDPVGVAVGSLTYKRAAMAPSVRKGASDEALASELKRARIALQNQQIGGSYERFEPQAVLESAGVKASADSAQTQAIKDAAQALSLNADLAPESKSFVAKTIAERLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFP6</accession>
    <name>W3VFP6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFP6"/>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="238" mass="26494" checksum="92A7B1B00A622A52" modified="2014-03-19" version="1">MNIIDSLFGRTKSPAERLRQHQRTLQKAQRELDRERTKLEQQEKKLTQDIKKSARAGQMPACKVMAKDLVRTRRHIHKFYQMKTQLQAVSLRIQTLRSNQQMAEAMKGATRAMGTMNRSMNLPAIQRIMRDFERESATMDMKDEMMGEAVDEAMDDEDEGVGEEEESDNILKEVLDEIGVSVGQQLGEAPTAALSAPQAAPQQRIAIGEGAAGGGGIGAGASKDEDALQARLDNLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFR7</accession>
    <name>W3VFR7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphotyrosine protein phosphatase I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFR7"/>
    <dbReference type="HOGENOM" id="CLU_071415_2_0_1"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="5">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="176" mass="19487" checksum="2CC328672ACF7ADD" modified="2014-03-19" version="1">MSSSSSSSKPPSASGGADKINVLFCCLGNICRSPMALAVFEDTCVQAGVRDRFGILDSCGTGNYHEGEEPDERTTALLVRRNIPYDAENFARGVRDADFTTFHYIFGMDTNNVRNLKTMAPRGSTARIRLFGDVDDNKPIADPYYIGGKQGFETTYKQVRRYSEKFLQELGLTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFU6</accession>
    <name>W3VFU6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFU6"/>
    <dbReference type="HOGENOM" id="CLU_006421_1_1_1"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="150"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="712"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="487"/>
            <end position="488"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="875" mass="96265" checksum="67BA0178DAD647A0" modified="2014-03-19" version="1">MPVLEQFKNFIRHGKAAREAPEGLTNDPAAAGPSIQVQPATDTQQAGFAPSDKALPVPAATSHSHAAPSTAAVAASTTSTTAAPSTSTSNQHQSDQARDMRQSSNGNHLAVPAAGSSKGDQYQREAERIVAEEREASEKMPYYEGLSERFQLIKKMGDGAFSNVYKARDRQTGQKVAIKVVRKYELNSNQNASGQGASDRQQDACHPLSALGRLPSSVHFFRLQQRGRGRHAAGARLMTLAPMLNPYTRRPEQESGTSASMPCKRQTARTELTTFYPPSLTLLVVLSPPSATLYLQNTLAHTAGSQDRLDPNFRKKNRVTEPSFPMFAIRPREPQNESPASSPLANNPSPYHFPHLHLARDPLVFIRPGLPAQHGILVALRPHSWPESGVVVPLISTPHVRANILKEVQIMRNLKHDGIVDLLSFSESRDHYFLVLELMEGGELFHQIVKLTYFSEALARHVILQVAHAIRYLHEERGVVHRDIKPENLLFESIKIIPSKHPIQRPYDEEKEDEGEFMPGIGGGGIGRVKIADFGLSKVVWEESTMTPCGTVGYTAPEIVKDERYSKSVDMWALGCVLYTLLCGFPPFYDESISVLTEKVAKGYYTFLSPWWDDISASAKDLITHLLCVDPRQRYTIDEFLRHPWCNVKDPIPDLNSADIALAKASEMPLDSPLLASMKSGNAARNAMMSPGINRLKEAFDVTYAVHRMEEEGARKRAGGGNPLGELNEEDESDEADEARRKYGEEAGRAVESQRGARVHNEASAAKAQPRQAAPQQQQQPQQQPQRQAQQYQGRGGADRRLAEAALYDGRAGPRDRGQNSNRKRGFELNMGNATLLGRRNKAAAGAPRLDNLGKPIIDGAHAAGVVPGSPMRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGL1</accession>
    <name>W3VGL1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_05918</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGL1"/>
    <dbReference type="HOGENOM" id="CLU_068297_1_0_1"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS59937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="237" mass="25127" checksum="B7D4A9B9810F758A" modified="2014-03-19" version="1">MSAAARYVGLSAGASSSRTAATRALRPRSIVCPTRALSSSSRSDHVAGASSSGAFRATAPAALSASSSASSSASPPPSSSSAGNLSWDNYLQLRRSRRLAGMVTTIPTTLLAGAAAGSYFLTLEIDPSNTIAGLDPIYINAGLTLACTGLGWLTGPTVGTAIWGLLHRKNAKQIAHKDHDFYEHIKRNRVDPTRQSVQNPVPDYYGEKIGSIKQYRQWLRDQAAFRRKAAHGLEQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGM9</accession>
    <name>W3VGM9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGM9"/>
    <dbReference type="HOGENOM" id="CLU_007563_0_0_1"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="317"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="779"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1033"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1139"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1033"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1059"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1213" mass="136362" checksum="1364998BFC64EB76" modified="2014-03-19" version="1">MAPVAGPSRGGIANVGTSRSATTRSTSGRAKTNKRVEQERILDRLLQAFLSERTQDPTRKAAQKAKAVHTIDKDSWSPADADEIASAIQGLSLKHSIHLDHELSLALRRCHAELLVSCDRSMHLADQARDSYKRRGLDTRHIHDPLIRPDNVSDAVRLLLLLSKPPDVTARTAANLMLNATHPARAQYLTPEQRRQAEKREWLSILVDEPLQGDAWMEHDDEHDNSDLSDWSQGDDDDHERRRRLELEYDSDKEDRRRRARLAAASSAMELTPATTAKMQQRDRWTEQRSSRADALHKLIVADVRNGPKTWTEVDAVRESLSALMGCSSAMYVCSDAGQYSLAEGPFAPSSLFLGISEQMQDVATLASTFNTLRHFVNATVTQSIHAVDALTRTPAVEAFAEQLQILLERLSLRLSELDADLASISSSKPQPLWQARYSTMLQLVGHVHHEASSLLLLSRLLHSIGFIAIDDRSTHAGIGAGILRSSSDRALIDGLQALLDFVHQQDTMAVPETVVADLSRCLLAACRPAWSSVCQLIRRGLSFAIMREDDPLFDDRLVQHLVKHDVSLATSDKSFWTSGYRARQALAGGNVDEDTEDGYSPPAFLQSIADDVITTSKGVGLLRSLGIDALGEVQPDSDLRRILNVEILFKVDHTTKGLAVDNLPDDDEDADATQIQHATRSLTGWEARSKLRRILFPHGTHSNRCMAEELPLTPDSQPDADEFWHGATAGTSRSASLRLLEIRLGRSLRQHLSPISAIVRKRLIEVLTSPAPEGGYALQSHLEACHGLLFMQRGAEISSWTESLFLDLDRRNGAIRAIEPSRLTSGFHDCMEDHQQRTAGRAWIDTSLVRFHKGDDDRDMRAAARSRSRIGRLADIRVEYDVPWPLSFVFPPECTRFHQSIFTSLLQAKYAHWKLASTVKLARPETLHMRKYWSLRRQAQWLVRTLIEFVQRDVVLDGSERLCVDLQGVVSLDDAIQTHTAAVAKMEMLCFHRADQSKVKELFDAAWRLGVDVVSTYELFIGASGRNEERLARRKRRERRRKRRDRAKQDGAPLDAIAEADEEEEEEEEAEEQEEDDDDEAAEELNLDRSIGEYEAWGAQPDAYAKRSAYEGFDASMADASMSADVSASWIESETHKREHFRIECERLRKALQRLVEELTMRVDEQIARIAATSALEAQDASQADHALHDHHYTRQRWQGLLYSLAWSDLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGZ3</accession>
    <name>W3VGZ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Las1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGZ3"/>
    <dbReference type="HOGENOM" id="CLU_031483_0_0_1"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="66221" checksum="176200D3431178EC" modified="2014-03-19" version="1">MRPPKRSPFLHARHTELLEVYRHLYPDSPLLPSNASSRAHRHTALSLVQLWINRSACPFAVETTALLVQSVILDEHMQQIAAQSHAPAATSSLHYALEQMGGGAELGVRLNYSLALMRFVNSVVDSHQTGGFAQSIAAIAARIGLPQWFVEIRHATTHEELPSISVCRHAARAALAWLHTHFWAPQLFDTHHGPRAARADASGSRQLADVEFGVSTEPTSSSQEEEKRRSERTKALRELRVTLKDYRELAKKVARDRSLANAAKADMRRLFKQLAMFVSRIRTLEPEFGAQLIERARATKGKDEEADVRQGAQDPDDVDECTKSALADLVNQLLQPGGLVPRSRSKRVSASASGKAMVLPDEVVAVWAPLLAYMRETYGRIFGQILAEELVDVAFRRPALPDDDDTDAEQDASADDPSWQGWKAAAMSYASYGKTAEAWLRYLITTTPVASGAATSNAQAPVGPLVSDVEVAELCLPLQLPASTGLLDLIAERNHELGARIAPLIAVLRVSAFVTTTELDANPGQGDFTSELDVMQTRLDGMQTLFAVDERVADVSMDDTRQTSTNHVNGSAASVMPQGWSAAPSSWEPTPFGCLNGRIPNLVLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH07</accession>
    <name>W3VH07_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="3">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NTAQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH07"/>
    <dbReference type="HOGENOM" id="CLU_610021_0_0_1"/>
    <dbReference type="OrthoDB" id="191192at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="9">
        <location>
            <begin position="90"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="437" mass="46653" checksum="4AF01C1022C76412" modified="2014-03-19" version="1">MEESSDTAPRRRKSLSQSIRARLSRPISRDSTYNHPPPPLPPLPISRARSADSIFGRTPNPASSAPISMADLDTAWSSIAPPAFPVPLQYAACYCEENVYVLAQHLASQLTRANRAAINIAQSQKQPAPGQALFVPVWDVHVLFISNAGKTVLLYQQAASKLPSAGSPVIWDYHVVAAVTAHLVPLHQLAVQSDATIARPPVFGDGDGWSRTWIYDPDSRLARTAVTAEGGELLRPVPKHEYDDQTFRPGDIAAGVIPPHFQPAFRYIAANDFLARFASDRSHMLQDGPAGSGGKVWSAPPPAWDPIVGAKADKLGVSNNLMRWYVDMAASEAGFGTVVDAGTWLGCQSILGSSLGATIRDALAVEAASSTQRALPVLSARDSRWLAPPSTARPAAAKGDASNGAARGGRIASPLFPAYLHASQQHRSRPPPPPPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH74</accession>
    <name>W3VH74_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH74"/>
    <dbReference type="HOGENOM" id="CLU_145563_3_0_1"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="91" mass="10307" checksum="02F7BABBE0A53879" modified="2014-03-19" version="1">MSLLRVSSSTLARVSKTPTFVMATRGYADGPTDKAGATASSKGWQQREQAQENQYVQQAEKEKLAKLRESIKKQREHLDQVENQLKDLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHF6</accession>
    <name>W3VHF6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHF6"/>
    <dbReference type="HOGENOM" id="CLU_024327_4_4_1"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="436" mass="51079" checksum="44766B945F02F7D6" modified="2014-03-19" version="1">MASGFLDALFRRPQRLIVLVALFLLLLSFSTYLSFSANGVQNVRDRWNSLPAFSGPRPTAQNAGASYPPPKSVADMYTHNPGTPSSIDELSKWAQVGDDGNLYPPTFVPQMANQAPRAKAGFIVLVRNSELEGMRASMRDVEEKFNRKYGYPWIFLNNEPFTEEFKRGVRQMTRSECRFGLIPKEHWGYPDFISQEKAAETRVKMKDTIYGSSESYRHMCRYQSGFFFRHELTLDLDYYWRVEPGIKLYCDLDYDPFVFMQMNNKTYGFTMALYEYFDTVPTLWDTTKQFIAAHPEYLAKDHGLHFLTDEPQRLLEPGWNLCHFWSNFEIGDLRWWRSKPYMDYFEWLDKAGGFFYERWGDAPVHSIAVAIMLDRSRLHHFDDIGYFHNPFNHCPANRKKYHDSGRCNCDPKQSFDREGYSCLPKWWRGAVEGEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHS3</accession>
    <name>W3VHS3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHS3"/>
    <dbReference type="HOGENOM" id="CLU_128366_0_0_1"/>
    <dbReference type="OrthoDB" id="2555303at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="133" mass="14406" checksum="CB02672350D1A81D" modified="2014-03-19" version="1">MEGHAATSARLLAMGSLSIRDYLKTALPQQDMLDIVPAPSAPSAKPAPEPQPNQAEGKAEVPFYIKRRGKGKGRPVMYNWSHSSVAQIYVTVEFDDMQATSTGDAGGIKEAKEQACMVLAARILARNARRITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHW1</accession>
    <name>W3VHW1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Elongation factor 1-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHW1"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="569" mass="62345" checksum="053A6C5239007E8A" modified="2014-03-19" version="1">MGKEKAHCEAVVVIQAESGVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTVEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYMVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGTGEFEAGISKDGQTREHALLSFTLGVRQLIVAVNKMDTTKYSEDRFNEIVKETSNFIKKVGYNPKTVAFVPISGWHGDNMIEPTKEMAWYKGWERETKAGKVTGKTLLDAIDAIEPPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKGGMVVTFAPSNVTTEVKSVEMHHEVLSEGLPGDNVGFNVKNVSVKDIRRGNVCSDSKNDPAMEAASFLAQVIVMNHPGQIGNGYAPVLDCHTAHIACKFNEITEKIDRRTGKSIENNPKFIKSGDAALVNMVPTKPMCVESFQQYPPLGRFAVRDMRQTVAVGVIKEVNKTSGKGGKTTKAAEKAGKKNLVDRQFERLLQILWIPAAEAAELLQHRPHIEAAQVSQLRGKDAKLDEEFETVRAIVSPRHRPAGALHANSVGLLESKVDAWYANDMHDARDPHGTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI33</accession>
    <name>W3VI33_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI33"/>
    <dbReference type="HOGENOM" id="CLU_015846_7_2_1"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="296"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="755" mass="82667" checksum="55EDB224129A2F7E" modified="2014-03-19" version="1">MSSAPQLLDAHHSDSLRDPNASIKRSNAPSKSPLASSPSLSSFLKKGAPIVAISPPAHANTDMVAQIDSTTANRAGWSGFASSPDSSPDVESQAPSLTTGSTSASIESLESVQDAHHRSLNARFNAGKGDAAYSADAGFVYGNGTAQPPTSYDSSQDGAKLIHSEFGYCANPDYRYTSEHRRGDPLPNPVEEEPSYFTVLTTYISYIILILIGHMRDYVGKRLFPKSYHHLMERDGYAALNSDFDSFYTRRLKARMDDCFSRPVTGVCGRTVVCLDRVALDYYSTFRLTGEKTRALNISAYNYLGFAQSHGGCADAVEECLRTYGVSSYGNRLGSGHLDLQQQTEKLVARFMGKEDAVVISMGFATNSTTIPAIAGPGTLIISDEYNHSSIRFGARLSGAHIRQYKHNDMKKLESLLRECISQGMPRTHRPWKKILLIVEGLYSMEGTLVNLPEVMRLKEKYKFHLYVDEAHSVGAIGPKGRGVCDYFGVDPAKVDILMGTFTKSFGAAGGYIAADRTIIDRIRLTNHANVYGETLSPPVLTQIVASMASIMGVGRNPDEMALLPSWVQLPRPLLDGSEGRERLRRLAFNARYLSSGLRKLGFIVYGHRDSPIVPLLIFHPAKMSLFSRMMLDRSAVLPPSQRFAVEQSDMSSDELKAIEDPANPANIERPARPPIVVVVVAYPATPLISSRVRFCVSAAHTKKDIDDVLRACDEVGSLLHLKYGSGGPGGRWSVDKVIDRCLDLVHWNGEDAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI50</accession>
    <name>W3VI50_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_05613</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI50"/>
    <dbReference type="HOGENOM" id="CLU_003589_0_0_1"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="209"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="557"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="13">
        <location>
            <begin position="1104"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="351"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="761"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="911"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="772"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="824"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="938"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="957"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1003"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1202" mass="132444" checksum="1E7C44E886242700" modified="2014-03-19" version="1">MPGIPAQPNNIPLASSLPKVSFRKIPPDESLLFHIPPGIIDPHALPFGYNDGAEYVKPHHYIRYVEPVEGDLKRQVEYDMDEQDQEWLDALNQERRKDGLDTISYETFEIILDQLEKEWFDLMTRVPPKVRPGAAAADAAAGTHDDDADSEGGEDSKCAICDDGEAENSNAIVFCDGCNLAVHQDCYGIPYIPEGQWLCRKCTVSPDRAVSCLLCPHEGGAFKQTTTGKWAHLLCAMWVPETGVSNPVYMEPIDSVERIPKARWKLQCYLCRHRMGACIQCDNRSCFTAFHVTCARKAGLLFRTERTRVSRHLYDDSDDSDEDGSEVLRACCHRHMPLQMRHQLKIDFGRQGAVDDDRPDTPHRASPFAASRTREQSVESGVGAPLISVSRRSSIVGGSDNRASTSAPRNSSKSARAYKKSFKVGPPLVPAYIANRVLEYMAKIHLRKKATAVQLIARYWSLKREARRGAPLLKRLHLEPWTASSQNKEQTDAQKIKKLHFLRSVREDLERVRMLVEQVRKREKEKLRQAHEIRDSLVEPVLFPFHADLRAAIAKFEAVDKHGFFALPVSKLDVPDYYEIVKEPMDWAAIKQKIANKEYESVEEMRTDVLKITINAMTYNKPDTPYHKAASKILKMIPDVFDELANIESSHLRFHQQHLQQEQAEAEHGTQAAHVVQVDAETRRHLLELGIEPPSVILSLLRDYAQMDDDEQAELRQQAYGSIPVPAPVVKQEHEDAREEPSDALAIPPVANLVQDFVQQIYVPPPPPPSAEPSTSPAEASEASASKTKSGASTRSTAVPKTARKRKTSDTPAAPVVERRSTRRAAAADDTASAEPSAPAAPFSASGRKLRQRAQSGGSATSPDPSTDAGATATAMGKTPSQASAKTKDGVQVQEDVGAHDSFLLFNTGWVLPEGSKRHRAGAARPEMIGQRPRKISAPESPSAAAPSALPDGVAMSTPQRPRSRTVPSSHPQPAHVAAHKTKPSGRQRNAAGKKAKAEDVAADVAAEEGVTAASSPLTSDDEAQDEAASSAQEAGHERKSKRTRQGETSAAKEDASGSTRRNLRARDASTERSASPPRKRLRGGATRSTSPVRDHSSASLPENGAKVWAKIETFPHFPAVVVTDERQIPASVLRNRPDTPHTVAVEFYGRPRSWGWVAPAKLAPLVFDEADAARFFKMAARKGQLNKVKEAYDEALTRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIQ7</accession>
    <name>W3VIQ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIQ7"/>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="180" mass="20456" checksum="F55393B6EB69DBC2" modified="2014-03-19" version="1">MRPLTEEETKTLFEKLANYVGKNLVHLIDRPEDPHVFRLHRDRVYYVSEASMRLAVSIARPNLMSLGTCFGKFSKTGKFRLHVTSLDYLAQHAKYKVWIKPNGELPFLYGNHVVKAHLGRITDDTPEHAGVVVLSMSNTPLGFGVTARSTVDTRKQDPTSIIVFHQADVGEYLRDEDTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIT0</accession>
    <name>W3VIT0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lysophospholipase</fullName>
            <ecNumber evidence="7">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04615</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIT0"/>
    <dbReference type="HOGENOM" id="CLU_013227_0_0_1"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="136"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1000" mass="110123" checksum="BFEB00BD2E88E1E9" modified="2014-03-19" version="1">MPVLTTLRQSPTYLYVKVYCVCALVTLFQAAPVTSRIPRIGQKLQLSQYRVIRTRLGPRIVPVEETSSLPATAIAAQQDASGNSSNELVISSDVLGSSESGSLVKKLWQRWSQRARDLAHVKQLLRADGEDFKAYPELDWDATVRRSSALHPEEARFLAKRQKRLSSQGEDSLKHLLGLAKSEDVHPLDVPLVALGGSGGGYRAMYGFAGFIAAAKRAGLWDCLSWAGGVSGSCWTLAAYYTIAYQNADRLGRHYLAVASELAHPMSVHALDTVARSSRGVYFLLGPLIRKAQAGIVGLGIMDLYATLTTTYQFLSREPRARLSRASFQFSKVWSRSGVSTAAEPMPIFTAVRVAPQDAPGVRPHTDSSLSKGQPPKRALTQHQSAASQALADNQAHQQSSELPRGVEARASTDDRTDVYALPAAKGYFQWFEATPLEVGSADAQGYIPTWAWGRPFVSGRSLERRPEESLSLLLGQCTSAPAGPLTGYISALLASLPKGTLMSRLLHFLNNFVRMKRWERRWGNPIRAGDEPNPFYGLNVAPIPKALESNTQRARIIGIGIDILHLPRLEALVRRRQTHQRLSSSLTATEADAESSAMHRLAKRILCDSEMDEYEQLARQEREAAETVPRLQRYLSVRWAAKEAAYKALYPRFVLSWKDLCVHKPGSAHTTSGPIDAVDLSRLEQQGFRTRKPELTLSDEWRSKHPGATAVPYLHLSLSHDGEYVVANVLAEEAGGSNDAQTIRPASILPRKDVDEWRELQVRLPASSASGSADLDHLEDGAAVELGMDSSAIADCRDAEVKPEASDAFASWESQGRIRLMDAGMSNNLPNHILARPERGADIIIAFDASSDVQAGSAMRRIHNFADDCNVVLTDETDQFDRTAPASLQDETACALEARFIEQYARVLRGTRNVDGSTFWLVYCPLLPNPTNPGYDPSTAPFSNSYNLVWTPAQVETLLKTAQANVELYALERIKQVMRRVYYDKKAARLATAHSQQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIW3</accession>
    <name>W3VIW3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Eb1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIW3"/>
    <dbReference type="HOGENOM" id="CLU_041744_2_1_1"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000007">
        <property type="entry name" value="Protein BIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="11">
        <location>
            <begin position="175"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="279" mass="31239" checksum="EDFD1593F1BB6D3D" modified="2014-03-19" version="1">MGESRTELINWINELLGFSYTKVEQCGSGAAYAQIIDSIYLNVPLVKIKFDAKHDYEYINNFKVLQDAFKRNRIDKPIPVDRLIRCKMQDNLEFLQWLKKFWDMNFPGEPYDAEARRMGAAAAPPPLVGAVSVGAARNAPAASARAPVRAAAATRPSATAPVRRAAPATASARAAPQVPNETIHALTQQMDEMKVSVDSLEKERDFYFAKLRDIEILVQERLAILAEQYPPPEEGAEEEEPPTEEHESLRQIQAILYSTEEGFEVPDAAEVAQDEEEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ02</accession>
    <name>W3VJ02_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ02"/>
    <dbReference type="HOGENOM" id="CLU_051208_5_0_1"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="9">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="270" mass="29342" checksum="82A2142F63673441" modified="2014-03-19" version="1">MASRSMGALRQLGAAVSSASRTSTRPMAAPIARAFSTSSGLWNQSTSSSVTLDHLQKQSETLAQSSANASSDVAPAKDEEQFVIPECLQPTESHAPTHGVHVATLHLRSYADGVPNLDLFADFARKAAYAIGIPVSGVAHLPTRTSLWTVPRSPFVHKKSQENFWRKTHSRSIKVFDANDQVVDRWLHFLRIHALPGVGQKADLFRYHELGVGDKLMDEAKALQRSGSPDAADSSSKPQTESNQATSTAESIKKIADGIVEQEMAREEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ04</accession>
    <name>W3VJ04_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ04"/>
    <dbReference type="HOGENOM" id="CLU_019846_0_0_1"/>
    <dbReference type="OrthoDB" id="2551464at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF71">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_5, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="396"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="689" mass="73674" checksum="7EE813BC2B870A43" modified="2014-03-19" version="1">MEQANSSQPPSSSSSSSSNLEPRSDAPIATHDPQRQENGQEQSPSDAHHASTSNVAEQPPPASSIPSSSSPSAQRRAGSADQFQQHSNDNATASAATSSDPAPTLWENFMASLRNVVHRNPSQPSNDAQPESHPDQPQIPRSAPAPASRQAQNQNEATNRSDTGVDTDDSGLPRPPLFFRLPFNGPDGNPALLAFHPQPLPNRNSQSTNAQSQSDTPARPSTSSASSDPQTSPTSGSTSSPSDRPGANADAGTHSAPTPPNAHPHPAGHVPVSPLYVPFGASPLPFSFIYDANTQTAWPIAQVTPGSPPGGPSPDAPQSHQPRLVAGPPFRIILDIHFAPAPEPEQPDPQKAAAYVKQLERADAELRSRMARLGIGSIGGFATASGSDDQDALLGCGVCLDSYEAEDRPEWIDGPRSQDEAVVAVPCTGHHTLHAGCLRDWLSKLPPSQWTCPFCRASLSARPDTTQSPPSHTAAHKSTSATTPPVHTSLRDEVRARERQRGWRCDAPACLPRYPNESRVDDAHLELPQTSDDMTTDLVKLSPCRHEVHLDCLCTSMRIENPNCTSDGLDIFVSDGEEDEEADDSQNALQQVAPSLADPNPGLHKDTVGKWVSCPTCRKEVWAQLPLRRKPHRPRAGIESQLPVTAHKTESATSSLHEPHASTNTNNDFSASVDRFEEFAVDAMLHPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ17</accession>
    <name>W3VJ17_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peripheral-type benzodiazepine receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ17"/>
    <dbReference type="HOGENOM" id="CLU_091805_0_1_1"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20464" checksum="C54BE9471E61AFBB" modified="2014-03-19" version="1">MSNLPGLLIDIPRNPILAVGIPVAVGVVNGFATKSSNYSADSVWYKSLKKPSLNPPSSYYGIVWPVLYASMGWASHLTVKALDRTPPGLGRDTAKKALSLYWIQLGLNALWSPLFFGAGNVGLALVNIGALTGTVGYWAATVKDVDETAGLLAIPYVGWLAYATYLNASIWWQNYGNAKFGKLKKEAKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ93</accession>
    <name>W3VJ93_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hamartin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ93"/>
    <dbReference type="HOGENOM" id="CLU_007465_0_0_1"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="795"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="957"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1204" mass="131712" checksum="9226E8E0E5B137FA" modified="2014-03-19" version="1">MPPPSFSHQTAVVLPRAVQSWLKELIQKIRSALTANDEIKRHSILSAIEASVEEHAQSLKSAAQADEANHPPAAGPSPTAQIKSQVSLRINDAIQNMLQGELGAQQDEKLPALVDVLFVAMPLLGPTSIVMEWWDLVLHPLLKSASIQNITANRARELVVRAMAAAPTTAYEDEPAPVAVWPAPASRPTDAPESAKASPIPSTSPRRARETPYPTSATMPASSSPSRQPQRSPSLTAPSASAGRSASVGSRQDTFRRFTQRILDLYLAEAAHESQQLRSEDARPRRGSAPDLAISRDLSGSGHLLRDPATLVWKGNLESILLVYSNQKPKEFFHHIAESFSEPTARVPLLFLLSTFLRLYPIHAYHITATALPRMLILSLQLDTSTTCVSLGVTALIMLIPHIPNWIANGGAGGLPTLLSIFARIVDWRRLGNGWETRIGDDPELAELRREKDEEFAEMDRLGKRLNIKPALRWNRLESSFDTTMSSPPNAEHLFTFLYGLFPCNIIRFLRSPVDYLRKASFDSPFEGPWEEMMDEVAVQTRASPILRRHTLHPALITLDAETELTDKQRWLDHDSADINAECLGLFLGKWHDVNPSHIVQAERQRNGSLDNDVPDDESIFSSEARLGPFDMGRRRSAAALMHPSSPSGSAHRHYQRVPHSVNPDDILLTYASLRSGAPLMSATVSAQTPSFDASPAPSLFGSVTQPLTAAAQRLDDSIGPTAVPQAKAPSSSSAMTASGTLSRLLPAASAAAAATPAIITAVGSSSASHMSIPASPATHAAHASIARVRSRSGSLSSVLSSSSPSPATPTSPTLPGRHPLASSHLPSDPLTPQPEPREKQALAPEPREKQALAVPPFAGSSLEAGSSDASIISFLQRENLLLRNELNFELYLKEQHLRHIGRLHREKVTDTALEAERQNLYHTVRTLRTTNAAQHAELERCRAEAASTKARHVQWEADLNNKLRAYREERKAWTSEARELKAQAEEDAAKIATLTRQLEETGAQLFELQTKMEADEPKLAKLEQYEAKIAQLTSCLAYWDNDVLKYEQQRNEMEKLLNKWDEMAYLVESTEATLSEVEQTCSRLEAENERLKQELNTAFDSVKALKVEKGKLAAQAQPGHEQALDTVAELEQQRGVLRDENEALSEKVLELSARIETMQLQHAANGHSTVDGPHGASGLAAASHPDEDDDVPALPHGLPAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJH4</accession>
    <name>W3VJH4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_03892</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJH4"/>
    <dbReference type="HOGENOM" id="CLU_059260_0_0_1"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01801">
        <property type="entry name" value="Ubl_TECR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000131">
        <property type="entry name" value="trans-2,3-enoyl-CoA reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="18">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS61793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="310" mass="34804" checksum="88C6F15A0597490C" modified="2014-03-19" version="1">MAFTVTVEKRTAPGKPASKGFPLTVSLSSSKSTLGELKTKVAAASRKLTVERQRITTEDKKPLLDDDKSLADLGVTSGQTVYVKDLGPQIGWKTVFLTEYAGPIFIHPLFYYFGPQIWRREFAPSKMQTVALSLAVAHYVKRELETLFVHRFSNGTMPLFNIFKNSTHYWFLSGFLLAPFIHSPWFSASSVAGTIQDNPKFIFGAAAVMVLAELSNAYTHIILKNLRPAGTKVRKIPRGFAFELVSCPNYFFEFVAWAAFTVLTLNPASALFAAVSTAQMYVWAIKKHRNYKKEFGKEYPKRKAMFPFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJK2</accession>
    <name>W3VJK2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">PaG_04855</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJK2"/>
    <dbReference type="HOGENOM" id="CLU_004652_0_0_1"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="293"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="560"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="804"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1035"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1103"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1108"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="661"/>
            <end position="663"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="668"/>
            <end position="674"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1151" mass="126543" checksum="98A2302967B5CDE4" modified="2014-03-19" version="1">MRKQLDPRIPTLIRNNVALNHRSFFVIVGDKGKDQVVNLHFLLSQSRVQSRPNVLWCYKKDLGFTTHRKKREQKIKNDIKRGVREKGEGDPFELFVSLTDIRYCYYKDTPKILGQTYGMLILQDFEAVTPNMLARTIETVEGGGVVILLLKTMSSLRQLYSLGMDVHRSYRSNASDDDPVARFNERFLLSLGATHDTLLLDDELNVLPLSKAKDIKPLPETSTGTGTGVGSTVRKGKERVKAEEELAELKDQVRETKVVGEVVRHAKTLDQAKAVLTILDILASSSLSTTVALTAARGRGKSAALGLCIAAAVAHGYSNIFVTSPSPENLKTLFEFVFKGLDALGYDEVADWDLQRGTGEWKDVVVRVNIFRGHRQTIQYIQPQDHQVLGQAELVVIDEAAAIPLPLVRNLMGPYLVFLSSTINGYEGTGRSLSLKLIQQLRDNARGVASASADDSAASSSKASGKDGKGSLSTGRAAGAALAARSLKEVELKEPIRYSRGDQIESWLHQLLCLDASLTRTSSAALKAKGCPHPSSCDLYMVNRDALFSYHPASELFLQRMMALYVASHYKNSPNDLQLMSDAPGHRLFVLLAPLKPGEGGLPEPLCVVQVALEGNISRGAVLNSLSRGTREAGDLIPWLVAQQFQDADFASLSGARVVRIAVHPDYARMGYGARALQALEAFYTGQLLDLDNVRDDLDDGETFAAVRDRKITKDTSLLQGDEIRVRDAARMPALLQRLSERRPEQLDWLGVSYGLTPQLFKFWKKAGYTPLWVRQIANDLTGEYTAVQLKALDTSTSTTGSAWLGALAADFRKRFVALLSYRFRDFATVTALTVLEAATHGAKLGETEAEISTSAPLGAVELRTLLTPFDMKRLESYANNMVELSVVLDLMPTLAALYFNNRLRAVREDEAAASAINAAEEEEELRLSGLQSSLLLAIGLQRKTPDEITAELRLPLQQALALFVKTVRLLVKSLRKVEKAAIAHDMPELGAGLDARAPLRRKANGSEGGDWSALKGDLNSELRDAGRDFLAQHKAQANPELDDDNADDDDEDDDEKDEEDEELRVAKQKLIDEMNLSKYAIKDDADGSTDWSQAEAEVANRLRKSGNDLSSINTTVSVKGAKRAVDDGDKSDSPKKGADKKGKSKKQKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJS4</accession>
    <name>W3VJS4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chitin deacetylase 3</fullName>
            <ecNumber evidence="13">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_04945</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin to form chitosan and acetate. Chitosan is required to anchor melanin to the cell wall, for maintenance of cell wall integrity, and for proper cytokinesis. Chitosan offers an advantage during infection as it is less readily detected than chitin by host immunosurveillance mechanisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJS4"/>
    <dbReference type="HOGENOM" id="CLU_042090_1_0_1"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000009">
        <property type="entry name" value="Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF135">
        <property type="entry name" value="CHITIN DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833129" description="Chitin deacetylase 3" evidence="18">
        <location>
            <begin position="21"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="19">
        <location>
            <begin position="139"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="374"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="424"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS61011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="485" mass="50995" checksum="8EE3A1198E9E9C24" modified="2014-03-19" version="1">MRLTALTVGAVALAAPLASASRFHERGLVDAADHPAGHLFSKRAATHSITKRQLATTSKNGLPYPPAGSDPPPASSLPKAWVDRYNAKKAAGLIPDIPRSITDPNTRATVYPAGTDMTNVCSWTVQKCDTGDIWLAPDNAVAITFDDGPTPQSPALIEYLQEQKQGATHFLIGSAIVWNPDMMDAYVKADPPMHLGVHTWSHTLQTGKTDMEILGDLGWTMQIIYDLTGSVPMYWRPPEGDVDARVRAIATEVLGMQTVMWNKDADDWCLRQGTGTAQLQTCTTGVGANKTSVISEMTSWATTNNRTGFISLEHETTDQAIDSFKAYHRALKQNNWNVGPVPELQGLPYYQNQWNLTSRKEQVDSILPTREPIKVVNSDARRGSKRAPDTSAYANLDGSGAGAQASSSARGAAASYTASVSAAGASSTGTSGSSGSSSSSSGSSGTSSSSSTSSKGQTTSGASSLLVGASTVGIGAFAAALALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKB9</accession>
    <name>W3VKB9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKB9"/>
    <dbReference type="HOGENOM" id="CLU_321881_0_0_1"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="647"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="892" mass="97032" checksum="0CCE9F373D027079" modified="2014-03-19" version="1">MSNHQDPASEPSLRSPRQSAATASTLAAPLPTPGSTHILTSESLEHPASASTALPAPAHLPQLDRCARESSSSLSPAPSSTPSAHSPQISQSARRASESQTTRSHQISAPARPSAVPYFGRSPSVQHCPPPSDLTRAPPSPHHPDLGGHVAARPDSLPAQPSTSSAQEGPPHAFHPRRSSPFPSEESHIAAHASQARLLPPPSTPTPAHSAAHNPHHQQHQPNSHESHPQKRAKHSAHAASQHPSAPSHPQAHFVNRPRKPEHHRLAPLPLPSQVSPPWHRSGSQPVPSNQTGPTRVAGREHPQLRQAFAYHPYPFPPNHGPPPRPPHIRSAMENPAQLAQAQAQAQAQAQAQAQAHAQMQMQMQAQMQAHAQAQQQAHNLRRKNAQDILVGQGFRGLKRGRPTDRSLPPSLKRQVPESAFYADLQRMEKNLDWTVARKRAELTDGLSRTPKIKRTLRIFLSNTCANQPFQMAEKQKAKEPSGSAANASAENADSTENKAEGALKSAESKEDEEEEDAVPSWTLRIEGRLLEPSFKSRANTALSAQASINRTGAHKFSNLVKTCVVELQRDPALYPDGSNIVEWHRPVPSVAPASGMQAGGGAGGLGGTQGMEAPLVASAEPALDGFEIKRKGNVPTKVKIVLYPAYTPERYSLAPELATLLDIKEESRAGVISALWSYVKEKKLLDETDRKKVKCDAALRSLFNTDTINFHHIPEVINRYLHPAQPVVIEYWVRTDKAEYKHSTAYDIELDLEDLAIRQKQHSVLSQFDTANDATSREIAELDDKIAQAAATIRNRASARDFLAAFAKNPQEHLRTWIASQARDLDAILGNNPVPGAAGSVSSFTAEEMRRAETFRAAWVDEAVIVNEAQRLAEKLQELQSQGAQPQPGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKN5</accession>
    <name>W3VKN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKN5"/>
    <dbReference type="HOGENOM" id="CLU_060791_0_0_1"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="270" mass="30087" checksum="DD27A34E547A0736" modified="2014-03-19" version="1">MALEQSLFLDSAIRDWVLIPILVVMILVGVLRHNVISLLNSPPKSIAAPALREQRVMARSSALRQNYFQLPPSSFQSRKAFLTEALSNGSYLQPKDKEEKEGPKNPFEPAGGMDGMMDGMKKQMVMMIPQTLIMGWINFFFSGFVLLKLPFPLTLRFKVMLQRGIETPDLDVTWVSSLSWYFLTLFGLNAVYRLVLGDDNAADGTRDMAAMSGAAAPMQGMMNPTAPGQAPDFEKLHLAERDNLELVGLEDSKTRWIGDGIEDRVLALYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKV3</accession>
    <name>W3VKV3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_239478_0_0_1"/>
    <dbReference type="OrthoDB" id="2564267at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1469"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1498"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1512"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1775" mass="187867" checksum="C8F1F7671674A718" modified="2014-03-19" version="1">MSSIAFPAFERAQQEHMGFDRAAEELYQSAAEAVHAPETSASDAAIVATSQQPSLQDSAEPTQAPQPKITKRVNARLQLAAALIEADNDRILEKAQFWHISHPQRPDDDLRPPPPPEPALASQSAIFAPYREGASLAVKRHVRTWSAATGLSRLLEPSDDGRRPSVDFLGVALPTEKRARSRAGSNASALAIAERPRSRADSIFSNAATSVLGRTSRVGSRPGSVLDVARDEDALSDAEVLSEWGVDKFLSREERDRLAAGQHTRTQSLTGGVAASPSLDNAAAASIPARKSLDAIRFPPNHTADVKRASSDIGTAPVTTPNPPATADAKLELLAKIKLYRERQENLPPSEWSGPGPTATKDQVVEHIIASSDNNKRASLREASEVLSQDQPPPAADGATASHQHRDQSAGVLATSAIHPPRPSSRADSNASSAFLGATGPVEPVNGIDAPSALTATGTTEVRETVEQEPSLAQTDADAAQAPRSLPPAPSQAIPIPQNSEAAGSKLPAQDSIAADIDMVGVGSYSRSQSRRNSFLGGPMFNPHGQTAIAFDQLESSSALPQRGSQPIAPSPLGHAKGPSRSWSQDLFAEHDLGLGPSPFAAALQAASPTLGPVPDASMLDIAAGRGPSPAIDFNSLTTRQLQAVARNSTFPSHLGINRDLLAEEELVQDAHLDQDEFGQLRKAKARPISYDFSALAQDLAKTGGENFEIQLGGPVAPDLSSANWGKPRKKWFRLSMMMDAKGKPAKPKSASHQDGDEGDAESDAEILSAPVAPVDQAVQNGETETAPNLSDMYAAEPAAKMAADTADAQEEDEGDVDDDYISPPRRGPLKPRGLAARMPKTLVMPQPLQGTEFAPKLRLVDPPNASVPAAHENKRQSLHVPDGFVLHDARGGLPPMRSLVVHSASGPQPMFVAKPKNKKSEQVSARLKAVEVGRTVQVPAAAPRGVGRRAAVPTTALFRNHLVQHDDEREGWGWEAGTRVDDMLNPDKTDDSDDDDKPLADIKKQGRSAKRAAKRLAKAKRKRKAARRVRREKREQALKEGKSFQEVGVEELSPDEDLDLSSTTSEEDETETDTDSDLWASDDDKRWVDDNKPAGKLYGKSLLDLATERNVERKSKARFYGQVQLEGGETTMLQIDGEDDTASQRPNGAAAGAASVYDDGASVALSVAKSFRDKPIGYNDTRERMEAVFGADQIWAREMAKRQEEEAREAEAARAQAEAEAEAAARQQLEAQAQAKPKKERSLFTLTRKNKKQRANLDVSNPSAMGSTASLAASNAEAISVTSSKRDAATDQLGNSADDPERSLTPVEPPVLALDIGDADDAGEEGVRGRMTPSLLAGEQKAAEEWLIASDNEDGEGKQDSSDDDDVPLAQVKKNVASRPVSLAAGLSLRPNGSGNADSSDEELPLAALKEKRIRQSMLLGGGKLDLDFTSTRDSGSRDGTGAVPSPSASSLRAASARGVAGAGAEVKEEDDDSDEDLPLGQRHPGGNAALAAVRLALEKEKRDKKEARQAQKAQQRAAKLARQVSTGDGDEEDGEQVQTGAKEDESGDDDDDDDSEDDKPLGYVHPQAAIIAEQAALIRQLQMEKEQQQQRAGDSPSGSGFASPSGLDVRSSMMFNRLSAMPSMGMMGGMSSMGGMGGMGMPDPRHSVMGLPGGGNPMMGVPQWDGMPAVSSGLPMGMSMPRGMSMGMAGAPVASPGSQIGGAGGMPPQAMPMTMPVPMMGSPAVAAPMTPNAMAMMIDPKASSIHNWRTQVPADATATVTPPGNVSAVNSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL04</accession>
    <name>W3VL04_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL04"/>
    <dbReference type="HOGENOM" id="CLU_012437_1_1_1"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="788" mass="87028" checksum="DA053871E9E9D86E" modified="2014-03-19" version="1">MKGLKKAMNLSRSKSNDSNGNRGASAGGGSVPAPPPKGGSVPSNPAYQGSLKSAASSKDASSSSASSSSSSLAASRANNVAANPIYSNNNNNNYPTGQGTPDRKLNPAGVNHILADKTPPAPPVVVVSPEMPADPIPHSVATTSQPSSSITPFHHTGSPGSPPPPGAAMASLSSTGIAASELATPPKAGTLNRLRQGPSNPGPKDTIPITAKTPPRKQRSSRFHVTEKVELEKLPHFNEVMPSDRPDLFVRKLRQCSVVFDFNDASQELEGKQIKAATLHEMLDYITTNRKVITDEIYPEVVAMFSANLFRSIPPQVNPVGEAFDPEEDEPVLELAWPHLQIVYEFFLRFVESPDFNTNIAKKFIDHHFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLNLRAFIRRSINNVFFQFIYETERHNGIAELLEILGSIINGFALPLKEEHKTFLTRVLIPLHKVKSLALYHPQLAYCVVQFLEKDSALTEEVLLGLLRYWPKVNSPKEVMFLNEVEEILDVIEPSEFVKIEVPLFQQLQRCINSQHFQVAERALYFWNNEYIVNLIGDNVQVILPIVFSALYQNSKAHWNRTIHGLVYNALKLFMDINPALFEMCTNEYKQQRQMEKQKLHEREEAWKRLRDTAIKNSKAIGVEPPATLKDEQAAPAGSVNPYDLDAFDSAADLTAGAESLFEAMGQGINGEVSTADFDDVDPNRLAQEGTAQEPQVAGEDSVDDMKDFPETARQQVGKQESPHVRRKSVIPMDPTVLAELAGHKSLDGADLPKPSGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL10</accession>
    <name>W3VL10_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04473</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL10"/>
    <dbReference type="HOGENOM" id="CLU_001832_7_1_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004188">
        <property type="entry name" value="Adenosinetriphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="415"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="623"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1074" mass="120790" checksum="51D1CED05A2CCE46" modified="2014-03-19" version="1">MSDSELRRWISDNSLRFFGLSQSSIIDFIQVSASSAATPSDLFQSLTSLGLPSTDDARGFVQQLHQRVPRASQSRSSAAPKTATSQDGAKSKKRYGLLLDDDGEEELAIKPEKKKKKRKEVKDSAPAEASSSRPSRSPSPRRSPSGAGSDDESRELARLKDLAERDEFARRMRDKDKSSTRNMVEDRTSSRNPEAAARRLLAEDDEARSAAMPSLRDRSRQEYLAKRAQQRMELLRLEIADEERFFRGMKMTRREQRDLDYKKEVLRLAEERARIDDADAGYVMPEDYITEKGKLDTAKKEQALYQRYNDARAERLAQSHATDAEIFEKEQIDRSRYVPEPANEAATELVDQYDYVFDETQTIQFVVESQMAGTTTTSAKDKLLQQQIDEAETKAAKIQATRESLPVYALRQELLDAIAEYQVLIVVGETGSGKTTQLPQFLHEAGYTKDGKKVGCTQPRRVAAMSVAARVAEEMGVRLGRECGYSIRFEDCTSDDTVIKECGYSIRFEDCTSDDTVIKYMTDGMLLREFLTEPDLSSYSALIIDEAHERTLSTDVLFGLVKDIARFRPDLKLLISSATLDAEKFSEFFDDAPIFNVPGRRYPVDIHYTPQPEANYLHAAITTVFQIHTTQPRGDILVFLTGQDEIDAAMENLQETSRALGNKIAELIVCPIYANLPSEMQAKIFEPTPEGARKVVLATNIAETSITIDGVVFVIDPGFVKQNSYNPRTGMSSLTVVACSRASANQRAGRAGRVGPGKCFRLFTKWAFKNEMDENTTPEIQRTNLANVVLLLKSLGINDLLNFDFLDPPPTDTLGRSFELLYALGALNDKGELTKLGRRMAEFPVDPQLSKAILASEQYKCTEEVLSIVSILSESSALFFRPKDKKMHADRARAAFVRTGGDHFTLLNVWEQWVQSNYDHAFCIDNFVQPKVLARVRDVRDQLAQLCERVELQPEANADPADISGIQRAILAGYFMNTARLQKGGETYRAIKQNTSIWVHPSSCLYKQIPQPGFLCYFELVETSKNFMRQVMQIKPEWLLEVAKHYFTKDDVQDTAKTSHYKGKTASGAALTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL45</accession>
    <name>W3VL45_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL45"/>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="41438" checksum="837D9ADDF173410A" modified="2014-03-19" version="1">MSTTTTTTTTTTSGFEAPKGNKDRTFGARFETKDLISFDENTVYGDWRDEFHKNGCVIIKNVISPERAKYYADKQIQWLKNFELGFDENDPSTWTADHLPISFKGGMYFAYASTHEKMAWEARTEPKVVEIFEKLWGTKELICSFDGMNISMPNRKDLNWSPWPHCDQNPERKGMQAVQGLLNYAPNGPNDGGLMLMRGSAKLFNEFFAHKRDSADHEDAPPPELKYMDLFLFSEKDIKWFEERGCEMIKCNMEPGDFVLWDSRTMHYARLPEGNQIRHVQYICMTPRAFANDEALEAKKKCFENWIGTTHWPHCNIRPTEDKPMRNGKICPKYRSEPFEKPELTEQVLRLAGVKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL51</accession>
    <name>W3VL51_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_03331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL51"/>
    <dbReference type="HOGENOM" id="CLU_013173_4_3_1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="411"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="481" mass="51130" checksum="B8D7858816135F10" modified="2014-03-19" version="1">MGQTLSEPVTEKTTGSGGNDSVLYAYSEMQGWRISMEDSHATILDITNAAHKNVGNFFGVYDGHGGSSIAQYCGRRLHNVLIEEDQFKDGQYTQALQKAFINVDEDLKSDPNYANDPSGCTAVTAFIQASQNDPKRLERIFCANAGDSRCVLSRAGGVIEMSHDHKPTLDSERERIEAAGGYVSWGRVNGNLALSRAIGDFEFKRSFDLPVERQIVTAFPEVVEQQVVEAEDEFLVLACDGIWDCLSSQDVVDIVRRAVANGKELQAICEDLMDRCLAPDSDTGGIGCDNMTVCVVALLNGRTKEEWYKWVKDNIDVPKNGRKTPDDVAPVFKNTQPAARDADGAMDGTVSIQSLLSGGLARGAGGAGDDEEGSLRLPGGLAGALSGAGIVFRPGGRSEGGEVVYEAHVVDEDDSGDDQSDGSSQDKSAADSTSKPTSTSTADATAEPRLVESPRQDAKAAAGGATHDSDKMDVDKGASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL63</accession>
    <name>W3VL63_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03347</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL63"/>
    <dbReference type="HOGENOM" id="CLU_028135_0_0_1"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="227"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="547" mass="59311" checksum="DAC2E0F6E49BB5B6" modified="2014-03-19" version="1">MCPGAGTERVDVWDFVGISTSQPAAVCPAAAGPIGAPRNAMGPPSEECELFGTPRARRNQPVLDSQIAAQQASQQRSHDETMPSHNSAGPKSKRPRSSNSRAKSCEPSSSNSDASSLQSGLPQHFATAYVYIDNIASGSTRSPRLDESEGLRRSSRSRKERFSQLERTSEDEGESDRKPRSADRSGPSTSSSRSAGPSSPRKRIKRTRDDPNSEVGSIYAHLKGLPDLFAVDNDIMFCGINPGVKSSHSGHHFAHRSNHFYPSLYLSGITQQRMKPEQDVDFPTLRPMSLGLTNLAGRPTAEGSELLPSELIAGVPVLLEKVQKWRPRTVCFVGKGISEAFVKGLKQAGAVSSSRQQSKQRSGVKVEVQDQDTLTHTVLDIQIPAGVLCADSGGAKPSSQRKPAPGSPKAKRPLYTKDSAKDDSGYGLLPLCLSHAKRTDRPLRLDEVTLFFVSPSSSARVTTHFLDDKARILSSLRVLVEHLKSAPASVVGRRDAIIKDEPGEAEQRLSQVVSTKRVELQMVDLAAFDLREGDIKPEVKQEASFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL81</accession>
    <name>W3VL81_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL81"/>
    <dbReference type="HOGENOM" id="CLU_141397_3_0_1"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="90" mass="10221" checksum="DB8A269C3F982E60" modified="2014-03-19" version="1">MDLSGLSSSEQQAMSRIIEQKQMKDFLKLYTGLVERCFESCCNDFTSKALSSKEDTCVSNCIQKFLKHSERVGARFGEENAKLMGQQQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLB9</accession>
    <name>W3VLB9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270962_0_0_1"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="274"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="600"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1285" mass="136413" checksum="49FD4EC0BC07CEA1" modified="2014-03-19" version="1">MREQSEHAPKKRKRGELVAEFRKRMLFSALDSSTPLFCNGERAITTGDPSRGWTGSSSSSSSSSSSGSGSSASSRTAPMPGQTSAASRYVSALSSPDLVPCDAAAQSSAQALMGTSAQDSDDLATQLHSVHAADAPHTSSSPVVAPLLQQRDSGSSDGSGSGTEASLAQSDICRTPSTSTTGSSHAGSLDTAISSVPSGTEFESNYKSHVEEQSADTLRVSVAAYDPSIAPSQASPISLSSEADNALLDYSPLPHDASAGASLVEAKFATAKVRRYAALLELIDTERNYADDLATLVLVFFDNLCMMPFFNDQPARQALVMRNSQDLLRTHQKLSAKLDAILVDLGLRKSGQRHADDQKTELEKALSPQADEAVVRAAKLFNQMMPQLQSYKAFCSRHGEALALIREAEKRHADWDAFERHCADILRLTQRAHKHTSSRPPSGATTPSVWATNSPASYFIPIASSSATPSPNLASGSTSTLTAATTASGSNPGSAAATPATAPSVMRQNSSRLLFRDFLIKPIQRLCLYPLVLQTLQKHSSATDDSVDELALAISLMREVADQVDEAGKRRESELRADLISSRIEPNQGVTLSFLKSLGDCQLSGTLDVLHHHRLLNPLTAPLRFKYFGVFVYHSFLLMVKVRKNSTYESRHWFPLWAARLSNVEDEQNLIPNSFRLSVRDHHFELAASNAKERQLWIDMLSLAISRATFSPPGSQAAFPCSLYFGDAPDGESLEASEAPTPNASRPAEFQGYFETAKAGTVDPLMEFLAMHAAGAAQATGTNNRGQRASSSGPWMPTEILLRHASSNSRAIVDRGMVLSDAVISARIARDGGALSTLYAASGSGIGSAVGSSLGLSRLSAKDTATVKIQRRKSCAGLLENADAEDDSNNLVFTATLVQPGSRSRSSTRGQLDAVSEREGWKSSLLKKANRVRPTSIFAPNGLSVNTDGLASPVWGPGSVSTPSSPITAGRDLLVHEFGSFGITGSVPLSPTTPTSHVAGIGGAELASHSLTSSPNSGSNSAANSTVNLRAQGHAMPTRSRTSLYSMKDSLTMTFGKRVRTRSVQGGVGEADPMHEFGVGSALSSAAASPMASNVSLPHGEVVDSSSRRPSADELYRGQKARSRTNSISSVTGSIRRVFTSASLATLSHKRGQSEAVKVGGSVQSERQLAETVVEEEAAKIGGTLRRSRTMLDYSRSWFRGSATSVVERVNAQAVAPATSPTASPMASPGQEQGSRGVGSKGEGMRRASDTHVGTVNAQPSRARQSSKVYNKLKFLHNNKLSPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLL1</accession>
    <name>W3VLL1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLL1"/>
    <dbReference type="HOGENOM" id="CLU_021377_1_2_1"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="7">
        <location>
            <begin position="411"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="474" mass="51545" checksum="C88203A4F0F61FCD" modified="2014-03-19" version="1">MATAGKRRLVVLGTGWGGYAFLKSLSRSTLSQLDVKVVSPTTSFSFTPLLAQASCGTLDFRSALEPIHSTRGIAFHHAWCDALDLCKQRIEVTPASKPEFRPADPLTPTSPTRAQERARTYSIGYDYLVVAVGSYNATYGTEGVKENALFLKDVSDARAIRWKILSAFEGTNAAYPQPLSKEDEEQVRARLGFVVVGGGPTGAEFAAELHDLIRQDLTKIYPHLARLASIKLLDAGKSILSSFDKGLAEYAMQKFARDGIEVVLNARINSVTDQGVWVQNPHGGAELMRAGMVVWSTGITAAPIVKALRGVAKEDRSHKWLTDAKLNLLVHKPARDKGEIRGNIHHPAPDKQEGDVVPMTNVWAIGDCSSQATPLPATAQVANQKGSYLAAVFNASPTHPSAQEPFKFKDKGSMASIGSNEALIDSPVGKDKGALAWLLWRSAYTIMAMSWRNRFLVPANWASNLLFGRDVGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLY6</accession>
    <name>W3VLY6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLY6"/>
    <dbReference type="HOGENOM" id="CLU_1636511_0_0_1"/>
    <dbReference type="OrthoDB" id="3359404at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="162" mass="17851" checksum="6EB80E131975535B" modified="2014-03-19" version="1">MLALSSRLASAAPTRNLGLVSLVRPLHTTQHRLFAQPPPPPPQHELNEAEQYLANKAARKAERARNPTGASARHASLYSQLFPALLRILAYGSTAYFGLHLLWNVLDRDEQTKLMNQHAGSLEGTAKSLADKVDHATPNLAPSTAASEPGQSQPKKRWYWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM18</accession>
    <name>W3VM18_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PaG_02428</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM18"/>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="200"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="498"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="966"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ETS62693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1058" mass="119382" checksum="7F1ECDC6740256FF" modified="2014-03-19" version="1">MAPVSTDTMARPTAGPSSSSKRKIDEHHSSAFTDTLKRLKEEADSNQDVDDQALWPRPDLEPLDVDNDAVTFQQIDIEEHQAVGQPPAIRMYGVTAQGNSVCAHVHGFLPYFYIHAPRGFTANTCNDFANHLNVLFGARTVHNAQVVSKKSLMGYAGQENVAFIKLTISDLRSLPRIRGSFERGEIGFRDLFTAGDVCLTYENIAYTLRFMIDLKIVGMNWIRIKEANYKLRPESQKVSLCQIELDCSCDALVSHAPDAEWSKVAPLRILSFDIECAGRKGVFPEPSVDPVIQIANMVTRQGESTPFVKNVFTLNTCSHIVGSQVLSFNKEIDMLEAWTKFVQEVDPDVVIGYNIANFDFPYLLDRAKALKSTKFAYLGRERGVRTEAKETHFSSKAYGTRDSKNTELQGRLQLDMLQVMQRDYKLRSYSLNSVSFEFLGEQKEDVHHSLITELQNAGPESRRRLAVYCLKDAYLPQRLMDKLMCFINYIEMARVTGVPFNYLLSRGQQIKVVSQLFRKANEDNYLVPAYKGEGTEDQYEGATVLEPKAGYYDRPIATLDFASLYPSVMMAHNLCYTTLLDKKTIDRLDLKQDEDYVVTPNNNCFATKKLRKGLLPTVLENLLAARKRAKADLKKETDPFKRAVLDGRQLALKISANSVYGFTGATIGKLPCLEISMSTTAYGRQMIDQTKAYVERHYTIANGYEHDAEVVYGDTDSVMIKFGVPDLAKAMELGAEAAALVSKTFVDPIKLEFEKVYFPYLLISKKRYAGLYWTKPEKYDKMDTKGIETVRRDNCRLVQTVIDTCLRKMLIDRDVKGAEEYAKNIISDLLQNKVDMSQLVITKALAKADYAAKQAHVELAERMRKRDAGSAPALGDRVAYVIVKAAKGAAAYERSEDPIYVLDHNIPIDTRYYLENQLAKPLLRIFEPIMGPKANTMLNGEHTRVVQVATSNVGALMKFAVKTVQCLGCRTPLREQNTPVCKNCRPRVAQLYHEKLARASALEVEFARLWTCCQRCQGSLAQDVLCTNKDCPIFFKRLRAQKDVEDAVNVVQRFDTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VME2</accession>
    <name>W3VME2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VME2"/>
    <dbReference type="HOGENOM" id="CLU_615571_0_0_1"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="445" mass="48865" checksum="4397A3E50F31F1E5" modified="2014-03-19" version="1">MSHRDSSLDSSMMASSPASSTSSLDSPTQGATATSKNGGAWSSSSSSSSPSWGRWVADKYTVQYAIPAAYAPAALQVCITAFPLGVLFGLVLPRITTFIGQMFFEGTHQEGLAWYAHAQLALYLGAWVVFHMLEFMVTASFNPTRLFSDSFLLNNGVHYHIAHLVALLEFGLTAHLYPSSKAIGWTTWVGVVGVGVGQVLRSMAMVQAHNNFSHIVADRKRPDHVLVTRGVYAWTRHPSYVGFFYWAVGTQLMLGNKMALLGFVGALWTFFSRRVRAEERWLLEFFGDEYRHNGACGSEADRILQLSSEKAHPDASNKGGISRVDRDDNGTFTACTAAFGAQLENVDKIPVFLVSASRDCNADRERLPPRAWHLAVLLQTQWSCQGLHDSSVLLIPQPPCASRAFISLGLLVVVNHHLDQRPPPSPHRASWLAADMSMQPLDLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMF0</accession>
    <name>W3VMF0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMF0"/>
    <dbReference type="HOGENOM" id="CLU_1016250_0_0_1"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="8">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="271" mass="29562" checksum="81B88B7B3A519528" modified="2014-03-19" version="1">MRILKARSALLSDFEVLHVLKEMESEQKARVKPSAQTQEGEPKTKAEGDQPAQGDEDDVWLSNVPENLRTIQYETISSLSQTSRPCAHQQAEAIAAFLDELKTRGYSINDSESKRGALGLNRSERLQIVNHAPQSVVELHTLVEELEERFHAHQIEDLISLVQTYLPFRSDVNALAAEGAQDDPDAIAAAHMDADAHATAGQISQFTGQVAAGADLGDPRGSGLAQVPEPDEERQVADVEYEEDPDVEMDEDDFVHEGLGGGGVEEADPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMG1</accession>
    <name>W3VMG1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMG1"/>
    <dbReference type="HOGENOM" id="CLU_1355159_0_0_1"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="202" mass="21747" checksum="0FA40B3AFEBD12A8" modified="2014-03-19" version="1">MSCKVLGELVLNSVDRAVWLRHAEWTGQLALAACVMINFFSDATSPAEHPPTTGKSARRRDPSQAKAAGLTHSDCAGKWAAVGSPERPGGPVENFGPFSPVFGQRRVQSAESQAPPKNVGAISAPPSSPPSLCTQPVYTVKMAKSKNSSQHNQVRKAHRNGIKKPKTNKYPSLRGVDPKFVRNQRYAKHGTEKALKAARAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMY6</accession>
    <name>W3VMY6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005990_0_0_1"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="741"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="800"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1242"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="920"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="881"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1328" mass="142862" checksum="DE01A9514B8041C1" modified="2014-03-19" version="1">MTAWTLVQIMRQSVRSRSGSLSIGGKGELETAQHSALPLTPLPRYEMGDREAPIILGILASHDKLYIPKSAASGVAGFAQLSSQHQGADGKSWDFALHQARVPSARATARWALLLAILKAHTDVRDPMASSSSCLLVRRSQVGPSMPSRFASRPSIAPPTNLGSELHGKVRGSLLRCHGNVVGPAVPASLHYFLPRSCLAPSTRQNGRLESEVSAPHDPGSSVPVSSTHGLQPIRRDGTRAVKCIAMRRRQLALEVGASSVLGKHELVSTILPRPAHFDVSVTTMSAGTHSRNADPALGTDAPTPDASVHHEQRRIGNICAILVRNLSLRPTRDRALQTLASERPGGSSRYHTTSDDADLTLSLARSNSKGKSKAQTEVAHPRRRSASWSRLDPNSSGDPSADELDDDLASPVTASRTLAARKRRDPRGRPAVLANRRRTSDHELTPASSAHSVGSADSLHAEASPRPILKRSSSTRDGRDARMQSGSPSNSSTSGFLDELGANTTMLSRSDSRSSSHSSHTIRRPSHRARTTSMTSSGSFRSVRFDESQMGLSDDTRRPTRASGRIHPSSRFSLFSHKSLAQIMQERMLECYVELSVVDSDSPTDKAAKAAASKNVFYRSPNSKPGLHHSWGYQGGDSILPQRDFNLSPGTLSPAAPLEASQLRIAVWARPPPAPLAGATSDKLASTRAAEEWKLVCQSSVDLRDLEPLSANLQDASLSVPPNSIVLGLALGANSLSGRASLSPAAPSLESEAAKSTAKEGKKAEPTLTRKPSEREAERTRRILESIVYYTVPLDSIIRPTDTGAVSGASPSSAMGKAKPRSPSLPRRTSRDGYASDPENTPVRKTTPDSAKGPHAQTEVSNTGLATSPAAELVLPGAAETRRRERRKAFEEEQRRALELSLRETKMMPSYSLDQARHVARKQAELRAMFAAVEALRQQSGSMLREPSGQIQLRLKREQQAARCEDVRRLASDEVRELERRKAELESKKAALEARRNAMRASGALFEAAQRTDKQLRDELSALRSIRADVSLDVHSQQASLLRDLEIIFPVELSDASSLLFSICGLPLPNAVASLPPAELAHEEKRWKDTVRHHVPATTRPIFHPFDDDTISSAFGMVAQLVLLLSTYLATPIHYPLATAGSRAVVQDGISLMSGPRAFPLYAKGMERYRYEYAAFLLNKDIEQLMNVHSVTVIDIRHTLPNIKNLMVTVAAAPPTSHTTRRSHIGKNEIALRSAAVSLPPVKDDAGHEAGTSQQAKRGTGLGIGLPKLPGAAQQAGEAEATADKLVTTRVLGAPSKPAATNATASGAIASVSRAFSYFSGSGGSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMY8</accession>
    <name>W3VMY8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMY8"/>
    <dbReference type="HOGENOM" id="CLU_1204628_0_0_1"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="230" mass="25633" checksum="8CE5F5B15F7E3647" modified="2014-03-19" version="1">MDLNQPRDDPHGVQRLLDILRRQQDASSSSAAPPSNPFATAPQPEADAHTSSDAAAQRRRTYASSSSAYTPAEAPFDPYAFNPFSATNAVLDAPPAAPPKKDAPRDLASLSFAESLPILSGLAADAGLMRRLKVLRTQQRELERRLAKEYHQFAATKERQYPHIKQRKEEDHRRRADALAQWDKCLQAQQQELARAGVPTFVPTTDRRKVETQRKVLAVLVDMLDDQEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN12</accession>
    <name>W3VN12_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN12"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04113">
        <property type="entry name" value="Rab4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001193">
        <property type="entry name" value="Rab family, other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041819">
        <property type="entry name" value="Rab4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26948" checksum="63AAEC0B9C49B4DA" modified="2014-03-19" version="1">MDDQASLEMSAAYDFLLKFIIIGEAGTGKSCLLHHFIHNQFKDQSAHTIGVEFSSRLIKIGNKSVKLQLWDTAGQERFRSVTRSYYRGAAGALLVYDITKRSTFEPLSRWLTDARALASPDLVVVLVGNKTDRGDDEREVGYLEASKWANENGVLFLETSSMTGENVEAPFALAARSILLAIESGKLDPEKAGSGISYGDRALRRVGSGSRFSFADMDPSTFRPQRRGGPALRIKEAIGDKMGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN48</accession>
    <name>W3VN48_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mig1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN48"/>
    <dbReference type="HOGENOM" id="CLU_111242_1_0_1"/>
    <dbReference type="OrthoDB" id="2553257at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833377" description="Mig1 protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19081" checksum="F9F80EC31DA4201E" modified="2014-03-19" version="1">MIFKTTLFGLGLGTCAGLAAAAEDQPPTALTINNAEYEKRCGAGSDPNYPCFTFVGGDLKDVHAEIWTIGRMFPATNFLLKDDQMRDFTIDDPNKLFSIDWRAFDVGMIYSPIDTSKACYRIQIQAPKQGTSRIWVNDGLDGEGIDLDSNTSFLGDHDFCSKWLRIHVGNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN97</accession>
    <name>W3VN97_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN97"/>
    <dbReference type="HOGENOM" id="CLU_047435_1_0_1"/>
    <dbReference type="OrthoDB" id="9971601at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF2">
        <property type="entry name" value="METALLO-HYDROLASE_OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34241" checksum="708EF3037F4A2E40" modified="2014-03-19" version="1">MAAVELHKLNGDTSWLIRLPLKQQLESRSFYNIVLDPWLHPTPQVDGLPLFSRQTRVEPAAFGSLAQLDRWLRSLPSDEALDAVLFSHPFTDHLHPETVRDEESLAVLRAVTAIFTTDDSLSALRALGIKGIPAGTIVDITSTAYRQDGGDTNVLPVGIEIEHLPARDWAASPAWHKLHSGILISCANATTPTQILYSPHGVTPRSIQARMQSPSPGKMARILIHSFDRQTLPLIGTVACGFPNVLDLIPTFQPDAVLATHDEHKRAEGIVGHLIKRTTVSLDKAASRLRQQHPHIPCVLKQLAPGECFIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNE3</accession>
    <name>W3VNE3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03358</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNE3"/>
    <dbReference type="HOGENOM" id="CLU_011245_0_0_1"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="92"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="676" mass="73803" checksum="EA7D2194AC62262C" modified="2014-03-19" version="1">MRASPVCSGIRGIFPLIRSLVPQAISPPFALSSLRGLRLAIDATLLVQRLHFADDPHPSRHVVGFYRLVTSLRQHGIVPIMVFDHPHKRLALKDREQLKRKHKRELDRVRSRLEHERHGRLQELQSHLDAIASLAEDERRQVGELLDQWQAQSIPTQQPAGLYKPELPVEASRPQTVAYSMHANYLQLEQSLRTGASSQSKGQRLLAQAEKQVYQTITAQLVSGEAVQPPPVLSMPDISATLDAPPPPSLSSLNAMHHSLSKTYDRATSPLSASIYQDCAALCSLMQTAVFWTGDGTRTGGGRIHEAEAYAASLVRAGFADLVASEDSDVLLYDAPLLRGLMGGVRSPGVLGQASRGKLEVVCGTRVRRGLFPQEEVDRLVQMHSQGEAAAEGVAYDRTTRALMLDFALLCGTDFNRTVPGIGPKTALRLLKEHGSIGTILRKEAKFGPPDALSLREYETELRQARNVFLQPPKVRAAARSILGTAAFEAATQIAAQPTTPQVDRLIGGESVSPRVQDKAVLEDAAMGDGEAVDCTAEPTAAEVLESISAPSETEATPSTSVEPASVRFDRQAVHDFLRSRGVFRSSLPDSHDLDYADPPAREQEWRDLLDLELGLTSPSPDTSPAQFDTDTHADLALATLGADFFGERNAVACWNPHMERHVRAETTAHPRHSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNE5</accession>
    <name>W3VNE5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNE5"/>
    <dbReference type="HOGENOM" id="CLU_030431_3_1_1"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="55777" checksum="E553B3137E9FA231" modified="2014-03-19" version="1">MADAHLAGGPSVRNTNTNIGVASDFASIPHTAGIPMASAVANAGAGAAGPGLGWRDPPKGLELAQVHYLVRHGERTPVRTRLTHLFPEKWNLCRAGREFDACVLELTPSADNSIPPYQVGQVGSANTATMHSSIMRMRRSVETESSRSGRGLPDEEGECLLGELTDLGRLSTLRFGRELRSLYVDRLGFLPQLLTSKDNDALYFRSTNMGRTIESLEQVIRGLHSNTVSPNTQGQFIPKVLVRNGTDENLLPNTYGCSRLQGLDRAFADAAARAMNPKLEEFDKEFESVTGGKPRVDGRPRLNGIVDTVKAAQAHGFPIPAGLSDKRMLQTLESAVVAEWFSGYNAPDPEQKLEFRRLAMGRFVNDLASRMAVRADKGEQDPLKFGVYATHDTALAGLLCTLDCFDGRWPVFTSSMGVELFRDTAAPSSLLSKVQRAFGLGQKPPHYVRVRYGDRDMQLPACAPKGKHYEGRPELCTLDAFMDIAKSLQHPKGWTWEQQCAVGQGPRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNG0</accession>
    <name>W3VNG0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03379</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNG0"/>
    <dbReference type="HOGENOM" id="CLU_004624_0_2_1"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000140">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833130" description="Glycoside hydrolase family 5 domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="164"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="500" mass="55397" checksum="2AA0665DE464333C" modified="2014-03-19" version="1">MKFSTLFAGALLAGSAVAGAITNESGNASDQKVKIPVTTANSRGASDVAPKLIATQIMDKVTDVLTASPVSKLMKRHRRTINNIEHAADSFDKRALPALRFPYQNGNRKVRGVSLGGWLVVENFITPSIYGQTGNPKIIDEWTFGSLQPRNKAVSILQNHLNSFVSEDDFRQMAAAGLNHVRIPIGYWAFEVSSGEPFLKLNQWDLLKQAAIWAGKYNLKVLVDLHAAPGNQNGFDHGGRRGVNAWAGNATNVQRTLNVLQTMSREFSQAKYANSVTAIELLNEPVTDQNVVLDFYKRGYEVVRYPNGRNAAESPLLVVIGDEFMSPAWSNYWNDKLLPPQYEAVSVDSHIYTIFDDNSLRLSSKDRTGYYCSLKPKIAAANKVHYQLLGEWTPAFTDCAQGLNGRGRGARYDGTFTGSKGKINSCGPKTGDASAFSDNYKRLLGTMWESQVDSYEAGIGWLMWTWKTEPKAAEDWSYQKGLQYGWIPKDPTKRPNGFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNG7</accession>
    <name>W3VNG7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNG7"/>
    <dbReference type="HOGENOM" id="CLU_031812_1_1_1"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="292"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="515" mass="55060" checksum="0ECA336423D951DA" modified="2014-03-19" version="1">MTGCFAFLKPSRARANKMSDHGCTCKCSQHAGALAAAAPTAATAAAEKSPLSASMYYDACNPPPFEPGQVQRCCGGFAGDGLAHSHLPTYGDSQKHAHHTVRYSEPNVDAQLSDAVAEVAKSIEAEMEKLDKELRELSLDMHDHPEIMWEEHRTHDLFVKYLSGKSGWKVTPHAYGLDTAFKAVFSHKADKDSRVIGFQSELDALAGIGHACGHNLIAMSGVAAALSVASALVEKDIAGTVVLLGTPAEEGGGGKIKLADAGAYKDMDACLMIHPAAMSGTGAMLAVHPVVVTYKGRTAHSGAAPWEGINALDAAVLAYNNISALRQQIQPNERVHGIIKGNNWSPNVVPGEATLIFNIRAPTISALKALTARVQKCFEAAALATGCTGEYDWQTAYADVHNTPSLSATYANFLDQRYRIHVPNDDFAASTDFGNITYTLPSLHAEYAIHLDDPRTQGNHTVGFAAAARTQEAHDRTKEAALAIAVTGAKVLVDKEFRDHVWKEWSAWRKAADGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNJ6</accession>
    <name>W3VNJ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylulose kinase</fullName>
            <ecNumber evidence="6">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNJ6"/>
    <dbReference type="HOGENOM" id="CLU_016149_8_0_1"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="7">
        <location>
            <begin position="332"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="625" mass="68081" checksum="ABB4FE5616682CB8" modified="2014-03-19" version="1">MQSTEALFLGLDASTQALKASLLDTHLTVLGELEVRFDRDLPHYGTNGGVSAPTADDDQGTVLAPVMLYVEALDMLGDKMREAAWPLARIRAISAAGQQHASVYFSRAAPHILTTLASDKTLTAQVERAFSRKVVPNWQDSSTVEACRAFEDAMGGAEALAEVTGSKAHTRFTGPQIYKFRKQQPEAYKDTERIGLVSSFVTTMLCVGEGEDAESVIKGIDESDACGMNLLDMRPASSRSSDERVGKIEPGWCQKLLALASGETDGDGSLGGAEELERKLGVVYRDAGASVGKIGSWWKQRYGFSDDCHIFPGTGDNPATFLAFSLAQRQAIISLGTSDTVMVATDQYVPDPDFHAFFHPAQSPDGGQRFFNMLVYKSGSLAREWVRDQYCNADWDTFNADVEKHRIESTSHKRVGFYWLRPEIIPAGASGVHRYTTASSQSDWNKVDDFDEAGMNASAILETQFLNYRYRSSSIVAGTSSSPDTSKLPLASIYAVGGASSNTTITQTMADVFGCDIVKPVQPSDDGKGWTAANYNFCSVGAAYKAVWGWSRTQLPQGEASPQFDDFVHATKSRQAAKAGLTAQGQDKVEGGVQVICRPRDGRTQIYTDIVQEWKTLEERSQKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNJ8</accession>
    <name>W3VNJ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNJ8"/>
    <dbReference type="HOGENOM" id="CLU_086812_3_0_1"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="195" mass="21764" checksum="EC9154772E7FEEEE" modified="2014-03-19" version="1">MEQSRGSMAAMERRKTLTERPMDVLYLSYFGIHLLASLAIDAQLTYPPYSQSVFPAPLRKVLQDYLTTSKDPFLLAAAAQSSAHVWFRVLLASETVFQIPCFIVAIWGLLNDERRTYPLMVCYGTLAASSTLQCIFSVLYGDDGAGLTSAQIRALLQNYIPFCLIPLLLTFDMMLRIVGLLDTPRPAKQTSGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNL0</accession>
    <name>W3VNL0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03452</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001471">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF15">
        <property type="entry name" value="ALPHA-FACTOR-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="932"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1013"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1124"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1154"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="40"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="484"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="893"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1475" mass="161020" checksum="F09DE48BF578582A" modified="2014-03-19" version="1">MPGKRKSESKATPSTLAKPSLRLLFSFLSRRDVVLLLLPAVASSIAVGMVPTAMSKVVGHAFDAFTSYGRDSATAAPHAAAEVNRHFINRILGSVYALLGLAAAMLVISTLSVSAWICLGERAAARVRFAVFHSVIAKKMAWYDTGMGLTSDDQDEGEQVEMSPAGLMTKVARECDDLRVALSREVGDVTQHITTAVASLVLAMYTSWSLTLVILASIPVVLVLTVVTEIGANPWLQRERTSTAHATSMVERVVEAINTVKAFNAQSRESARFDEELASGSKSYRRMLLWWAIRFGVTGGLVFATFVQGFWFGAHLVSKGKLSPGQVMTVFMASLLVSGTLNEIVQALSYIDKGKVGAANLVNLINSPDDDRAAHTQAERRGSKTASSIHSTGSESDEKHHSLTTHTKSTLGSEQVFDILEYDVSRAKAVPMSIEHIPTTPSPGIHSPDNFTYRARPRVHTIRGARRAVQGLRRIAPATCQGEVHLRGVSFSYPSRPDTCVLRNVDLYFPPAEMTYVVGGSGSGKSTLAHLLLRLYEPSAGTIQIDDQTIEFLDPHWCRQHISSVSQDPIIFDMSVHDNVALGLVGIVQGSATSGIPSVAREEVEAACRLALLHEFVRDLPDGYETSLGSNGTALSGGQRQRLAIARARLRDPAILILDEATSALDPTTRHLVHEAIKTWRRGKTTIVITHDLSQIEPDDFLYLLENGEVAQQGYRSDLEAKDGPLRSLSLQQHQRSQYEDQEQEQVVEQLEAVGREEPQGRRRRMKYRSMFGWEREAGVLSEHLSLIISQKLDSTPSHLKPLRLAERQAINTYFEDAETLRASGSTASDRRARTVPLERRRWDEVQTSHVLSETMIHTGAPEVEKAGAAKVATMREVWRILWRTIPSRALLVAGITLCIMAGALTPVFSFLLAQLVATMGRPDQQAAVVKWSLLVLLVALLEGVFSFTRYLLVETLADAWLLRLRSSSYRHVVAQDRTWFDRGENSAARICQSIVKDGEDARGLVGQIIGQLALICSMITLGIVWALVVGWKLTLAGVAFGPVFLAATFCQSRVISVYEARNKLKREAVSERLHAALSHIRAIRAMGLESVFAQLHQGALDDAQRCGMQASVFSGFGHGLSDALTYIAEALIFFVGAKLIVSGEYDFARMMQVFNLIIFAVTFAAQMLTFLPGMSKSMKALVDLDRLVRLQEADAQRGEAKGEMTCDVKGDIEFRNVGFAYDGRCERVLDGVQFRIGAGECVAVVGSSGCGKSTVAALLQRLYEPSSGEILVDGVSVSSLSTAWLREHLSIVGQNPSLFDLSIAANIAYGANTKLYDPLDTSLSDSDLELVHQSAHAANAHSFIEHLPESYATSVGGGATGSGSKLSGGQAQRIAIARALMRVRARILILDECTSALDPANQQLIVETLLDAKAALRQRRMTTLVITHNVDMMRRCDRIIVLKNGAVAEHGSFQQLLSQNGYFASLARAGEWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNM2</accession>
    <name>W3VNM2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNM2"/>
    <dbReference type="HOGENOM" id="CLU_052104_1_0_1"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000277">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="5">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="342" mass="35796" checksum="E74656B69F3315AC" modified="2014-03-19" version="1">MGLLKSFAATSRRGLATSATRSSYADTIGNLAAGPHSNVIVQGFTGKASTVHTQISLDMGTNVVAGVSPSKGGTKHLGGRPVFNSVQEVLDAGIKVDATSVFVPPALAADAIIEAIRAEIPLIVSVAEGVPVKDQFRVMEALHSQDKSRLVGANSPGYCNPRGCRMGISPMITAAPGPVGIASRSGTLSYEAAYATKPLGQSYILGLGGDFYPGTRTVEALEFLMNDPETHAIVLAGEIGGTMEEEVYALLSDPNSKYRQPKGGKGTFTKPIVGFIAGLNTPPGQMFGHAGAIWRDDTSSALEKRQMWTEVGIRMADAIADVGKLVREEMSSYGLEIPKSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNV0</accession>
    <name>W3VNV0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_02967</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNV0"/>
    <dbReference type="HOGENOM" id="CLU_014629_3_1_1"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="17">
        <location>
            <begin position="57"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="18">
        <location>
            <begin position="314"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="16">
        <location>
            <begin position="523"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS63185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="746" mass="82215" checksum="DC9E415AF61EF4D7" modified="2014-03-19" version="1">MSNPDPKSTTFQPLNEPTGDWPAAKVTLSIPMGEVAARTSQDIAKARAAADFAPECIEEVLRDSRIDNDSRKKVMNTLAKDPIFGNWKKRMIHMNREQQMRQSHFACRRLLELAEKHEWTTHEVVEAALTLDLQSPITIHWVAFVPVIFGQGNAEQIERWGNKAMNHEIMGCYMQTELGHGTNVQQLETTCTYDDASDSFILHSPTLTSTKWWAGGLGTTATHGVVQAQLIIHGKRYGPHLFFTQLRDMESGKLLDGIVAGDIGPKTYGAFGGLDNGWARFNQFKIPRDQMLSKHAKVKKGGEYVKPPSDKLSYGGMIFIRSQMIDRTGWMLSRGVTIATRYALVRRQFRDPSSTDINDVERSVLSYPSTARRILPLLAKAYAYILAGRRMRTLYEDMAQQLEEGNTELLADVHVASSSLKAYCTKQALDGIEECRQALGGHGFSAYAGFTSVFPEQAPAVTYEGDNIVLASQVGRAMLKISGELDQNSGTKVAATSGFLRAIGTKGAIPFSQPKSASDWYKPEVYSAALGLRAAQLVVDLRAEIKAGRKFGDLSYECIEVAKSHGEFVVDLWFGEGVRDDAESFGEREVKWLNKLVTLHALVALSRNITPLVLPASAGRTLAGYAHGQAILTPESVILLEQAIRELINEILPQVIGLSDGFGWLDWELGSSLGRKDGRVYEQLMADAEANPLNHPGAIPNLETIDKVGVYKYGSNDIGKGVPDWYNAEIGPLLRAAAKRGEASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP15</accession>
    <name>W3VP15_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP15"/>
    <dbReference type="HOGENOM" id="CLU_061621_0_0_1"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="291" mass="31702" checksum="E32C46F2C0E41FB8" modified="2014-03-19" version="1">MPERSTGSMIFIGERCAFDECHREDFLPFKCGDCRQHYCSNHFRPQAHRCSHYDDKDLDYRVPLCPICDQPPQGWQRDQDPNIAMDRHLSGQCPMLDSNGHLKPDASSPAALKMKRVKKANECSFVKCSKIMVVPIQCPQCAASFCPSHRAPNQHSCQHSSSSSPSASSARIASTAPASGSGGIKSAFQNLKISTPQLGSSSMPTKSTGSKLSATAPKPTAASSTSQPFGKMFDKSEKRAKAERLSAIRAMQARQRKGILSDADTVRLAEEMAALSKTERIKASDSDCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP28</accession>
    <name>W3VP28_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP28"/>
    <dbReference type="HOGENOM" id="CLU_042192_0_0_1"/>
    <dbReference type="OrthoDB" id="2552560at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="452" mass="50214" checksum="A98ABEA8FE7D6137" modified="2014-03-19" version="1">MSQTPTQTPSRRRAAVDTPGSVRSNTSTSDRSVLLERTEELELEIEDLRRAIASERERRRSTQRQLEKQRATDATRDEVRTTLLEKLRQMDDDALTALLGASVQSLARVIAGADSAWVAVDAGLVPSKSVGVEGTGSASDIDRRLALSAQGVQHELHRTRHAASVNQWLNDRQRRSNALVQSLAQFSYLDIDTLDQASSSERRSIHLAGSFARLFPIDIRFVVDDSGSSPAIQHLAIDIPSWLSTTLNTPHALFSRLLKRNDLPAVLLMLRTMVPLLSLRRNMFTSLMESYTDLVRSHIRAWESSHGIDFAPWYPPGTSRKRASSRVDETLGRSLIATDAETLVLQNSHGASLTLRFRIVWNRYGHAVPQLDAEPNVPAGLMDPTATAFLQQFDHEFKHLCKVAVQQDGIVGWQDEEQDQAVGRWGLMPALHATIAAFFRLAIDDASDTGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP46</accession>
    <name>W3VP46_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP46"/>
    <dbReference type="HOGENOM" id="CLU_453397_0_0_1"/>
    <dbReference type="OrthoDB" id="2550141at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833420" evidence="2">
        <location>
            <begin position="26"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="593" mass="66729" checksum="6F75D7164A518AA7" modified="2014-03-19" version="1">MAALMLSRLACWLLFAAISVQLAWCAGDFVPARHGQDASSSSQLVPQTFAEKYRIIDPVSGRPWSELEYKHFADQAIPLIDGVKYYKKNWRLFRTVGADKIRHVGVGATPADLLKHPYYVDYSMSGSHIPALSIRVADMLPHNPMSLSNPDVVIFMHSISVDRQTDAKFRLEPRFVVRGSAGQGRVPETDGPAHNIKWQKRQPWKPEYVWVEEVPEIFRSEALRSIEALGYPPLTIDGQVALLDRESSVNLYAAARSSKLADLLEQSRLYMFQFVPPQAKGTLESYGLMRLPIDGNREAWFQGPLFDRFDPLTGHIQLKMYTSMGKRTPVLDRVMYTMSQQGRYRLVPRAIVRPTGVYPNVHFKTIYAIPPELQQAASVDLSYMPDLDRPVPTSSDLDRPLRVMMDRPRPLGHPLDYAASHLFRLPTNGNKALWPGAAGQRVARQTDRSDEPGMLGRPTQNAMANKIDEGVRLSSAGPRRLPHSLHGAAPQQDSPGVPATPGESPEVEMVDSLAANPQVEHHQAFHPPVGPLRSEEFRAHPPAPPRHSHHQPQYFDYKPGRPNPYELPRDSPIDVLMAHLEPDVEETRHFFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPE7</accession>
    <name>W3VPE7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPE7"/>
    <dbReference type="HOGENOM" id="CLU_267873_0_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1167"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="965"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1104"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1167"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1255" mass="136829" checksum="C52B4C3010E6CBB8" modified="2014-03-19" version="1">MSVPTRSGSHAATAESSKDVENANACPKCGKTFSRAVNRDRHLATHNAVPSLACSICQRRFHRADVLAKHVLRHRSRSSSSDDALSASAHAQQRSPTPPKGRPSDSHTLSTIASAPTNEPRNLSPSVRSLAASRKVSKACSLCNRAKVRCDGALPVCGRCSRLDKAILCKYTLPANAMQPAAEQAGQSDSTPAHVAGPSAHVSALIHQDATGSMQHAVDFDSIAAAVDHLVDAPPSTNGRQLGTSSFDPGLSTSSFPHHFRPLDSLDLESWRQSQAQTTDAAAWSSALSPLPVDWLLQNEIPDDNWAAYLGDPGVPLIGSYFEQPEPSFPRWRYDAHHAASSSTPHATIAIDAALPVDPANDHSHSHPSAHSRTPLRTRTPQNSSHVAQAHRQPSAISPASMDANAAAATLARIRSEAVNRGLLRSASPSEDDSSSSSSCGPEEVDDNTRGEARAATHPHRQNGPSHGASKRRRSRDGAADGHAGPRRSYPPRSPGSSSESSDLDPMERANRDIAAQPRQQRVSYRHPDPSARNHLNASPAAPSPEDVAMQELVAEELAQRNHQNEQVSGRSPHTATSDRSSKRRKRRHKYWPSVYRPKATDGGRHLSLQKVPFASDEVIALENSYQVAPMTDQAKERMIDEFRFCEVEPQDLRRIQDTLRSTETATLNVFVQLYFEHHDAILPILHRASFDPDTCDPLLLAAVTCLGALCSKAENAFAYSLLTSSLVHAVSYKLIGINHLRGRYLPSMQTLLLTYALWRNLGDPAKLEYVEGFRNIVLTMARRCRLFELVPFVLDPKAMGSSQEQANDAEILARKREQEWQRWIRNQEMVRMSWALLALDSDLSLAWDLPCTVTIAELGSPLPCVESLWQAESAEEWMGMSMEQAASAHKSRLSDLLCTSRLGVGGTRQTGDRLATQASAAKESSMDLRHSSPMTRLVLSAAVHNLVLSRWNLDTVLSQYANPQDDDDGEDDDADSGKAVLPHRDPALQSWVESITAKLNHLTSSRLDTSSKGEAQLMLHGARLRMLVSFKMVQIMSGRKGHRRAKVQMKRWLKGPLQDESFRTDLFSEASKIFTLSISSRRDIAPLNLASSSSSSHAAVNVSTRGRSASRSSGNGAFERAGPSSFDSSGTGHATFSGTGAENSILFYATVCLALLCQWLQQNQRSEPSRDQSGNADVSAEASSPAGLTRGSSVSRKTRRKDVYFLSGVGALTHAMSLDRLIHVAVHQGLNRSAWPLGYVLGKVLQQWARTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPF1</accession>
    <name>W3VPF1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPF1"/>
    <dbReference type="HOGENOM" id="CLU_691156_0_0_1"/>
    <dbReference type="OrthoDB" id="2547067at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42076" checksum="CE2F4F993DCD9EDC" modified="2014-03-19" version="1">MEAHGGQHVRLAEDERTRDSTTEAACGGRSRPTRIEALPPELLLYLSRFLDLASAIVLSTATCRNLRAIFGQFDRELLYLEPGHRLCLAEWREAAAQLQNHGLSTESPADSSTPPSAIDQTAKPKTTLDVARVVHELTRDESLIDLDLLKAVLDFLSRRCTSEVSQHIRVDAVMPSRWASGNAGANKIRTLHLSGWHGIAGAFLIQQLHMQPALRRVCTVVKTERADSRIWKQVAADDPTLVPPSFWPSTQPDPQQDGESGKPGFSRCTSTQIIVRVGRRLPRRDGQAYLRGEGLQMGYEGYCIELNSPKQLSVPSSDEALKSSGPEPPSTAEAAASTGDRLHVVLQGREDTDATLGGWTHNEQLWVRSIVTCNHCKAPIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPF3</accession>
    <name>W3VPF3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_03307</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPF3"/>
    <dbReference type="HOGENOM" id="CLU_037666_0_0_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002577">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="463" mass="49077" checksum="507CA2F423A01D2B" modified="2014-03-19" version="1">MARTQHFAVQAKMPIYSVGFVQDNIIVYSGGGGAGRSGVTNAVVAARIDLASQSIDKLDECSLSRDEDAPMAMAINSAKSQLVCGINSTADRVKSGSNQPIRIFDYAISPQADSASSSQSEKPSTSAKVQLSLASASSSLHIQDPEEYVKVVSFSPDGRMLAVASTDGQVSLHRYPSLSPVWNDVREPSSSAIAAAEAKDTSISLASRDFDKAEIYDADFSHSNTHLVLTSSSKLVVYATDPFADPDSDAASTNGDAASAPAEGYAQTIQTIKNPALGGKGPCSFRAARFGRGEASKEKLFTVVNAAPAGGKGPKAKIRKSFVTAWDADTWDLIETRHVSDRPVTVFDVSADGKFLAYGSSDLSVGVLDAKTLRPVLKILHAHDFPPTCLKFNPASNLLVSASADNTLRIIPIPAKALLESAARSSGALAFIAETRMGFYTTIFLSLLIAALALWFQRQYLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPL2</accession>
    <name>W3VPL2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004718_0_0_1"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000018">
        <property type="entry name" value="TBC1 domain family member 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="1161"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="740"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="932"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1435" mass="153033" checksum="A49D12A905AEF8FB" modified="2014-03-19" version="1">MASPVRTPDLAKAHPLFSGESPTKSPGPSSLVNRPIWGQRKAAQVDYSADAPSALQRRSVSRNPSFHDSTSATPSSNSLRPVPADGDVFASRSSTSSTLPASCDADTSHTTSYIPRTSRVSSYDLQFDDADEPDIPNDSLFGAPEPSSPRLFDRELKAPRATRPATVYHAIPQQVSPDQTPMPKHQSHRPSSRSGLRDGAISPSHGRIRRSPAPSTSRSGVSPANAGSRVNELARELEFPVDWLQQLHRLADADLEAALAGPLAHRPLTNQQPRESTPVKSSASAERRNDARSLPYHLQLTKALSRALAEANKQLDQLRISAAEERAQHEQTLENTQQRTESREAAFTALCLDHGIKQGEIDRSLLRAPVLDAEVLKRRRLAEQQRNLAQEAASAQAPSKPADMALPDSLQEAMLEDLEGVANTSQRPRSPSLKPSSIHSAIDASPSNRRSPSLRSHVSTTSTDGANPQRQRGKSLSLSISSARDKDVDQVSIKSSAGVTADSLGTSPILRQHPSALRGSPQRSASPHSLHKPKSPHVASPRARSTSSSTSVGGGLGDWASGLLPWSGGGASRKAAPSTAQSMVKATSPGRREMAQSAAASAADAKRSVSASKGSKAASSSTFARAFGRYTRSSPTPEPAPAVPQPNVTRLPDTYQFDRRGGGDPTEFLSAAGGSAVLGAPSPRPPSAAVELEPILPNDAAPPTLIRRRKKGRKSGSSSVAGLGITSSTSEDLSDKLNGKDAAAAGKVVASRATQSSADAAPSPARRNRAARLSTLNEEDSSGDEFEVYGGKAPVPGFAASGLEAKPADEDTSVIIRPAAGDESDADSEMEEEFELLTDRYGFIYNPTDADIRLLRQARKASAPAPATLTGIKVGIRARGGTDSQSEDDKNDPDLDMEDSDEDDDARLAHPIDAQNGTGVEDQTSSQNKALSATDTAGSGTEGTASDGGGSTDSTGAKSRDKRRSQLLSVVDSKPVRAEVLPVSAVSQPVRSASPTKRRGTRSAASSRSSSPVKGQAPGFGTPRAGLPSISNTVRRLLTQLKDMHDTQQVEQKQRWDGFLERRRARLKPSSSEANGLGGAAISNAVGGVAVAKSSSTSKTKALFAGGLFGAAHADGSEAAGLAEKAPEEDWSSGMVGVSRMGDSKSGKEDWRDFLALCQAGIPLCYRARIWAECSGANDLAEPGRYQELLSEHQGETNECLTQIDLDVHRTMPTNIYFGGDGQGVAKLRRLLVAFSWYKPSTGYCQGMNNLAATLLLTHATEEEAFWVLVCLIEKILPSEYYTSHLLVSQADQRVLIELVREHMPALHAHIDELGVDLPAITFAWFLSLYTDCLPVETLFRVWDVMFVEGMVILFRVAMAILKLHERELLATSSASSFYGLAHSLTSRLFSVDKLIHLACTELKSTIRYANILEKRERHVADLTSELGLDLTTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ12</accession>
    <name>W3VQ12_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ12"/>
    <dbReference type="HOGENOM" id="CLU_082184_1_0_1"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000011">
        <property type="entry name" value="Probable MRPL23-mitochondrial ribosomal protein, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="251" mass="28053" checksum="BD4DBCC0792970B2" modified="2014-03-19" version="1">MSQFVGNTSLAFARTWHAVSAQDRVLGPLAVNIAKLLMGKHKPIYDQSKDLGDYVVVTNAKQVVVTGRKADQRVYRHHTMYPGGLKEIKYKEMMERKPEEIIRKAVSGMLPKNTLRDRRLERLKIFDGEQHPYAQNIIQRYPLGLTRSLSTSIPRHFWKRLFGSPERTPASAPRPTPEPIASASPSQLDTDTPAAAQTTKPVVKGKMLQRDAELLAKLLDRDGGSAAIPIINGSYAEGLGPETKKNMFRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQU3</accession>
    <name>W3VQU3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQU3"/>
    <dbReference type="HOGENOM" id="CLU_633299_0_0_1"/>
    <dbReference type="OrthoDB" id="2548294at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="452" mass="47827" checksum="C313F8B24673C783" modified="2014-03-19" version="1">MQSPRLSESLTREAQANIWQGPASPPSRASKSATPLPRAIKRKPAPKVPIELLQEEPITPVPAQQTIVLQERSLNLPTDNATAAPKPTSPMPASPARSQQHPQKQYILDIDAPAENRRASTSADASVQELLRSATLAPSSAAARPRKGPLRWMHDKDEHAPSTSTSSLQPRQPALSRKTSISAQLKLSLRRNKVENQPAGLVISAPTNFVHLSTGTEGAYGSAGGSSLRRSSTTSAASRNSSLRSSITSVSSASSFGSEAELATASNHVDQDKALYSPSEKKHPLRPLKSIRRPSKLTLQDVSLPPIPAGTTSPKDKRKAIYAAPGSVPAILEPTTDDMPTPTATTNAIVAGSPGTSPAGAYFAATLDRTLGRARLEAETGSPEPELSRSPSSAYDSSAPTSKRSSLASLHQFSSFLDFPDLPALSRTNSGEGVKHDDLWSTLNPHDTVATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRC1</accession>
    <name>W3VRC1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02372</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRC1"/>
    <dbReference type="HOGENOM" id="CLU_003705_0_2_1"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="86"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="353"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="655"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="997" mass="109684" checksum="979480A1C681F7CC" modified="2014-03-19" version="1">MSPSDSRRARNAYIVLALSVCAALAAILAPSFGGSIWQSLRSSIGSTFLRTHATCALADPAFAPVSSTMTDATDASKWFRLPRNVVPTHYDITLKSDLEALQFSGTATIDLDVLEDTDSIVFNAAEKLALSKSLVLSQALKTDNKSFVTLDIDAKHERATAKLPNSLPKGSKAQLVVAFASDIDKSMMGYYRSTWEHEGKKGYYALTQFEPTAARRAIPTWDEPNLKATYTFRMIHRKDTTALANMNVVSSNDISQSEQVKLLRAAELGLDDILATTGKTEGKTEGKTELASTASNDWTVTEFATTPKVSTYLVAWANGPFVSIESSYTSPLTGKVIPMKVYTTPEYIHQAQYALDVKVKVLPEYERVFDVAYPLPKLDTLVASDFDAGAMENWGLITGRTSVYLYDPEKSGLQSQKRTAGVQSHEVAHQWFGNIATLDWWDNLWLNEAFATLMGEVVILDRCFPEWESASEFINVHLDRALDLDGKRSSHPIEVPLQGENVEDAINQVFDAISYSKGASVLRMLSNMIGEDVFLKGVSIYLKKHLYSNAVTKDLWNGISESSGRDIASIMANWVLKQGFPVLTVTEDADGLTIKQNRFLSTGDPTAEEDKTLWYVPLMLKTVGADGKVAVDRDAFLNSEREVKIPLANAKDATYKLNAETIGVYRVAYSPERLAKLGEEAAKKNSAFSLEDRLGLVSDAFTLASAGYGKTSGGLSLAKALRNDPTYLVNSASSLNLGTLASAWWEQDAKVTGAIKKLRADIFGPTAKKLGFEFSADDSPDLKQLRAVAIAAASAGEDAWTLGEIKKRFDHLATTGDDSQIHPDLLRTTMARAVEHGGEKEYEAVLAIYRKPSTPTHKIAAMLALGASKEVKLLERTVDFLFGDEVKEQDFMFFFAALSGNPAGRRLIWDATKGRWEALSKRFAGNFSLSRIIEYSFSAFSSEQDAQDVEQFFKDKDTAKFSMGLSQGLDAVRARARWVERDAEDVKQWLQANGYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRS4</accession>
    <name>W3VRS4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRS4"/>
    <dbReference type="HOGENOM" id="CLU_008420_0_0_1"/>
    <dbReference type="OrthoDB" id="2591449at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1083" mass="115149" checksum="9D1C76573A1A088A" modified="2014-03-19" version="1">MAVPLAVPARHDPKQSIMEGRSPLTPTDLGLNTSLSPSSSMARLFGSTCALTILKGDADHPVNARAPIHQKERASKPSTPATNPPRFASSFSSLRSASNAASSGFDSTVNVHAVADHGILLPFLDRPTEVKELLFDTKANEALMYRLCRVFGGDPERPTQRGYDERWDEMLELLTELDRPLLDDEDWLVRLESLVMERSPELWAQLARCLGAEGLTLHPSAQPASSRFDSWALPSRYSLGRDNDSPLSAPSPSSSSGDEDQGHRQRSLSVSVEPLDNLPQSFSEQPAGRMHSSSLRDAPSSMEANESSSPAEPFAMSAGDESGAPGSLEDIMEEPSLAVQAGRSATRRPRSHSGKFAGLRISAMTSVSPPASRRTSVTSASLAADSSRDASPLPTGEMSPAGLAPTSPARSPSRGPSASFSKHRRLSTMMMQNNTSQQPRSSHDSSPLMSPKASIGRRQRGVSEATVGGALAGHQHRQPRRRAQSFARSFAELKSPTEHLEQLRADHAQAEADRLADDTRRISLQDGNLAQPGHAENVTSGALGLHGDSLSVPKEGKPAKAATRRHRVGSMGSRTSVSSIGSTSPSLPGLLPDGRTRHPSGSFGSRDLSESIAAFRATMGMSTSPASSESNFAENADTSSDAEKSTSSAARKRKGSGGAELPKPTSRTAETGEAKVSRTGSPRNNEQVQDHLQQPKHMQELESRNRAARGGGSGLALGGGFSFAKSGANFRAKTHDDAPTSQAGWRSSFARRDGPRSRGEPYSYRSPPAVHRRPGGFVSLAQEYERARSGRRASESVFSFNSNALDSSPSSSQASFDHAGDGSMPRARQASSEDLIPRLELTVAPDSGEASTRKGSTPDVGKGEPTPKAAPGGGITPRASFTTSKPPTRDAGLGYPFPNLLSRRAPSEELKGDSSSTLAPATPLSPLQACHTHLGATPPAPRASPRSPSIVFPISPNPALSRAREFSRAVETPRCQDAFARVRSVCGDDTASGIRALITTAERAELPDESLLEEVAHRLGLVDHERARMRGGHEAEDADVKLAEEGYAERWHAFADLCSSLGVGQYELSMAKRRCGPAIDLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS46</accession>
    <name>W3VS46_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS46"/>
    <dbReference type="HOGENOM" id="CLU_447736_0_0_1"/>
    <dbReference type="OrthoDB" id="2549609at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="612" mass="67100" checksum="6B8A7625F803DE54" modified="2014-03-19" version="1">MTRELEPDRNETTPLLSYRERGDGERRWSIARRRSSAFLSFLSEPDDKDGDEFQEYHRKRAIYLMVFISTVYNIGVGIYNSFAVELIQTLACAEYYHVSSPSAPDATFPTLPTAGDPLEICSVPWVDKRTSQMATYSDTLSSISGCIASLVLAKQVLPRFSRRAAFIASILVSLITCSLLAMLPTHYSFDSSVPSSSTVHPTVAMHLFIALCFVGGLFGAFQTALSLLGQVMMLDVCKEDEKTAAFAKTFASITLGMAIASVVIRLVLPAFHLNFSILHHTGPFSPFWICVGVWLIALTIATLFLPETKRLAPAHRRSRRGSDASTATDTSGSHIQTASPLTTQPSASPSLARRVVADIQETLGLFGYLVPYKPGPGAKRDYKLPLMMCALVFCDTITLIWSNLVVFCSTHLHFGPPEVTTLLGLLGATKGLYSLFALPWIVKMVHRAVKRRMRDEIVAASIEELPSEVRIAKREQSVIFTDQIVAMASLSCDCLGFVAMGVAASHLSVPGIYGTVFFLLLGSGALPSIQALNVDLFLAQDRPAQDLVAARDAFVGFLNLLQIALYTFCPLINNAIYTWSVDHDLPALVFFWTATLSFTSFFFVSTASLFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS96</accession>
    <name>W3VS96_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS96"/>
    <dbReference type="HOGENOM" id="CLU_002173_2_4_1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="937"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1275" mass="140480" checksum="877D8AD1A3BDA7E7" modified="2014-03-19" version="1">MRWSGAWCLLRASLGVNYVLSRRRRRRRVTRRRAYPPPLAKPPPPSRSSSPSLSNSQCLAAMSFHFTGAGRSRAPVTLGGTSTSSADPASSARAQRIEREQQRQRQLASIRIQSQARRILVSKHTRSQWRTDSAHLLTQAQANLAATAAAPPTADLIHATRTLLVSLGPTTRALDSTDVQLFLQWIKLVSHPVDGIPLVFHPFHPHSQDAAASWVSLLKLACKHALRFLTVSASSRLTESTASPSSLDLDLETLAFLGLLTGVDARSPAHFINIDNQHASLASALLALLLDLGLHHTLRTHILSFTARQKSKASSLSPAVSLALAPLHRFKAASVPPSTASGVNAANAIDIDGASSPDAKAADIASQAIHSFAVEILTIPALRKRLPLDSVTELAKNLPFTSVLDWILRFKPPSIQAPQLDATIPSSSVETQAAQALQQPCLLSNLLAFGSQRVAFFKDGATHAKYLQALTSAQDWLPASAFDPSINPAASTANGRLPKALHHEAAIEPDLSDAKEIYERLRVLVSDQHLSAVLAVSNRFPAATRGPLFSFICATLAAWPTDMHDHVLNRLLYSGSETSVARDNKQQRHNAPTGTGLIREVWRGYVRGSSLARSLASAHNDTRAREILASLSSTSTSTDWPALVLVFELLSNVLLTLGDDEFYPSDNQFGGSNAANAAWLSRDEIVSISGLLRNVAFAMYWYEGKAPLVNLHDEELMEARSHKRTPRVPGMRMTLLSLRSLVTKVLKQLHLRDSRRRFAPADHWLMVSHLDLNDFMRTVVLEEQQLSSEQHDESERSDGISPGNADGSTPSSHIAAVAHGVDADMRDGEDSDEEMIADDDAQSRQPLSRLQQLRARGDTRSRHLTALNLAFLSPRLGILNNVPFMIPFDVRTQIFRQFVQIDAVKNGIFADRWQRRRAVKIRRGHVAQDGFAALAPLGAEIKKPLEIVFVDQFGNNEAGIDGGGLFKEFLTSLVREAFDTNRGLWKATDAQELYPNPHTYATSGDQLEWYGFLGRVIGKALYEGILVDAKFAGFFLSKMLGKQSFLDDLGSIDSLDKELYKGLISLKNYQGNVEDLALNFTVTDEEFGVSLTRELVPGGANIPVTNLNRIEYIYRISHYRLSTQIQHQCNAFFTGLADIINPRWLRNFNHEELSILISGSDDPVDIDDLRKHTVLGGYHDKDLTVEHFWHVLEGFDQPMRKAFLKFVTSSPKPPLLGFSQLNPMFAIRKAGDDTSRLPTASTCVNMLKLPDYADEATCREKLLYAIQSEAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSB6</accession>
    <name>W3VSB6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSB6"/>
    <dbReference type="HOGENOM" id="CLU_033265_1_0_1"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.280.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase UHRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="163"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="442" mass="49150" checksum="1EED2CE2EB957549" modified="2014-03-19" version="1">MVLDTLGADDDYEAQRAANIKANLELMMSLGLYQTSKQLNPTTPKPKPKAKAKPTPSSEADSPRSEEKRERPRRITRSVSRAESPQVPRWGLKRAGSDQGMFARKRRLADDYDPDTFDAESDEEYAPRRRGALNPARHHRDEGELQRRADRLGVRIHDPKTFGAIPGIPVGTLWEKRMDCSTDAVHAPTVAGISGNEVEGCWSICLSGGYEDDVDLGDTFTYTGSGGRDLRGTVNNPKNLRTAPQSSDQKWEGKNAALRKSAQTGRPVRVVRGYKAMNKYAPEEGYVYSGLYRTTHAWMETGKAGFKVCKFRFQRLPNQDPLPTFDQQEEGVESALTSPEPSPSPEPEAEAEASPAPSCASVASVASMGSAASRSRNPLLSTPEFDRAQYIIISDSEDDEDEDDEIEVVLELTVPRNRAKEHISPRKRRSSRLPPMRKKYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSX3</accession>
    <name>W3VSX3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSX3"/>
    <dbReference type="HOGENOM" id="CLU_058877_0_0_1"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005085">
        <property type="entry name" value="PRK06520.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="388" mass="43178" checksum="5F89D5C075511E65" modified="2014-03-19" version="1">MSLPSGNPPTMLSVNPPFRHAHVGSFLRPASIHTARSSFAAGSISAAELRTIEDREIASHVHELLENGVQEITDGEFRREYFHLDFLKHIEGITISKNTLEQKEGRVPPTLSVTGKLRHTHDIEVDNFKYLQSLVPASEVKRIKITIPSPTMCHFRGGRAAISSEAYPDLEQFFSDLAAVYRKEIAALYAAGCRYIQLDDTNLAYLTDETMRSQAASRGEDLDKLPLDYARLINASLADKPGDMVAAIHLCKGNFRSQFFAQGSEDGYNPIAKVLFQQLNVNAFFLEWEDSRSGKDFSALQHLPPNKVVVLGLVSSKHAKMESKDELVKKINDAAGEIKADDGLRQLAISPQCGFSSTVHGNEITKQTQFDKLRLCRDVAQHVWKDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT08</accession>
    <name>W3VT08_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT08"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="356" mass="37378" checksum="802F626B2DB3CDF3" modified="2014-03-19" version="1">MSLPSSHKAAVVPEAGAQHQVVDRSLAPIGDDEVAVKVIATSINPVDWKMRDYRVFLSEYPAVLGSDAAGEVVSAGKSVTNVAVGDRVFFQGIIGNYDSSTFQQYVKIPAALLAKTPKKVSDEQAATFWVAGMVVATGFYHKSGMSLSPPWNADGASVCKGKTAVILGGSSSVGQYAIQFAKLSGFDHIVTSCSASHFDHLKSLGATTVLDRSQATTAEAFVKAIPSDSSVDFVYDTISSPSTQLLGVQILQALKGGKVLVVMPADEKAVKQSEEKDLPDTSVVAILGIGSHPEYRYISEPLAAHLGGENGYVAKGDVTLNRPMVVEGGLNAVEKALKANKDGVSGVKVIIRPNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT54</accession>
    <name>W3VT54_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="16">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PaG_02332</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="16"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_25_0_1"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001445">
        <property type="entry name" value="Chromatin-remodeling ATPase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001304">
        <property type="entry name" value="DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="21">
        <location>
            <begin position="707"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="985"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="1558"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="239"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="927"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1761"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1788"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="771"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="635"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="935"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1766"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1811"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1852"/>
            <end position="1863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETS63996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1873" mass="210261" checksum="BEE12F11B9114737" modified="2014-03-19" version="1">MSGEDRGASYRYPGRSAAPMADAYGRYDPDSNPEAAPYPYDRVHPSEYDRRRYDRVQATYETAPSYAADPSRSPAAHPDYRRSAQPAYRYAHDYPDRPLVQQPADRASGPRLADPYRANYREYDDRSYEVSRSDPYASRSRAVRRDDYQSAPLHDLDKSRHEHPAYDRCSVRDEPPQRAVAHPRADEMSYRRPEYDVHAREIQPSYRRGEHRSPMLPSQPVPNEHALRSDLATRDYDAAPSRDAELRDAPDSPPRPSMSIFNMLNDRAANGDSHSSHSSPAKSVVAAEYDGQRAAQPHAPQASLGAFDPARESSGSSARGAAPHPSRRDERHRRLDFTPEPEDEEQGHHPHNGTASKYRSDLNESNTEAPVRVKEEPYASARMTDDLAGPKAPSAGAPDSLVHGAEKSEVPHPATKNGSAKVGLKLRNNPLPPSKSTSSFVAPPPPAKKNRDPDGWESDLSNDENRSAWQPELDDYVFDMQERLRLIEDAFEAGLHEKHVEVEKRVARAYEGRHFAMLRQVRIREQQEASQRDMERRHNHVRQQLDHEIDLELLGTLSDGQVSGSKGAKRRKGGRDADDVDELLRDGDEDDADSDDVALADIAARTNGSRANIIKLKRSKGKLGAAGGKRRRLDASGAASSPAPGSDADSTLADLNAAFDGDESAFASRQASPIADDASFALDLDAAGKVPIDSRRAQQLEDAHRRIWTTIAKRDVPKVYRTVLQSASSKVMYWRRLSSVVQREAKRGAARNNKTVKDVQLRARRVMREVLVFWKRNEKEERELRKKAEREALERAKKEEEMREAKRQARKLNFLISQTELYSHFVGSKLKTAEAEESEETAGSSKMIDPNGVPAIDPHAEVADAEARLAELDEIDFDDEDESNLRAHAARNAQEAVRLAKEKAQAFDVAAAEERKRNEALARERDGLDAGPGKQIDEKDLGKAFDSDDMNFMNPTSMGETEIKQPKMLTCQLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISLMAYLAEVHDIWGPFLVIAPASTLHNWQQEISKFVPSLKALPYWGNVKDRAVLRKFWNRKQISYNRDAPFHVLVTSYQLVVSDEKYFQRVKWQYMILDEAQAIKSSSSIRWKTLLGFNCRNRLLLTGTPVQNSMQELWALLHFIMPSLFDSHDEFSEWFSKDIESHAEQKGTLNEHQLRRLHMIMKPFMLRRIKKNVQNELGDKIEIDLFCDLSARQKMLYRGLRANISVAELMDRATSNDEAGLKSLMNLVMQFRKVCNHPELFERADVRAPFAFADFARSGSLAREGDLLNLPHSTTSLIELQLPKLLVREGGLCDVPGHASRKGFDTGYLQNLLNIWRAPHVYESLQQKDSAFASLPLIGVSASEAEGTMHSSGIKRILAAAAEERRWRSIEAFASDDDFAAASLRPMGKVLRPMPSTSGRAPSLLMPLEEVAADYRRHSYLAKDSARAVVAPAVAPPIRLYSNDGPFMQSQERFSQDPQVSATLFGLSPEGRESVQRVAELERDLPDVPPQGVLRDSSIDQLPYNGMQVPQMNKLIIDSSKLAKLDVLLRELKANGHRVLIYFQMTRMIDLMEEYLIYRQYKYLRLDGASKISDRRDMVTDWQTKPELFIFLLSTRAGGLGINLTAADTVIFYDHDWNPSNDQQAMDRAHRLGQTKQVTVYRLITKGTIDERIVRLARNKKEVQDIVVGNKAYSETGMAKPQEIVSLLLDDDELAESMLRKKQAEEAQTAQDKADSARAMVAKRRLNKDRAAAAAQSPAPSAGLQWSLEEDEDDFFGARPPSKAETDTAETTPQPPSRKRGGPSKRGRASEASERMTPLELDGDASMAGTEGASSPLKAKRKPKSHRKKTVDELAGVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTC3</accession>
    <name>W3VTC3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTC3"/>
    <dbReference type="HOGENOM" id="CLU_2134605_0_0_1"/>
    <dbReference type="OrthoDB" id="2553016at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="113" mass="12261" checksum="BC2B88BB89631C04" modified="2014-03-19" version="1">MQHCKRGDRVYFTIGQNQEEGVVESVEHRDDGTAMATIRFDKKDGAVSHINRNVDKLEPAHASRRAREVDAILSLTAGRGAGNISFAGRNGESSFHLHVGACVRGRGCEAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTD7</accession>
    <name>W3VTD7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTD7"/>
    <dbReference type="HOGENOM" id="CLU_008964_5_0_1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="26"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="604"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="690" mass="76207" checksum="3712B665BCECBB2C" modified="2014-03-19" version="1">MAMDQSLIKLVNKLQDAFTNVGIQNPIDLPQITVLGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQLINRPAAAKTNGDALPAGANKGANNPDEWGEFLHLPGEKFFDFDKIREEIVRDTELKTGKNAGISPQPINLRIYSPNVLTLTLVDLPGLTKVPVGDQPRDIERQIRDMVLKFISKPNAVILAVTAANTDLANSDGLKLAREVDPEGTRTVGVLTKVDLMDAGTDVVDILAGRVIPLRLGYVPVVNRGQRDIDQKKLVTAALTAEKEFFENHPSYRSKAQYCGTPFLARKLNTILMHHIRNTLPDIKNKIGSQLAKFQAELASLGGPMGENNAASVVLQIITEFANEFRTVIDGNSNDLTVNELAGGARISFVFHELYANGVKAIDPFDMVKDTDIRTILYNSSGSSPALFVGTTAFEVIVKQQIKRLEDPALRCASLVYDELVRILAQLLTKNASFRRFPALRERFNTVVIHFFKKCMTPTTKLVSDFVAAQAVYLNTGHPDFISGHKAMEIVNERLNPPQPAHDPKKPNPHAINNDKDLDVSLKNESGFFGSFFQKSANQPSQAVKAKKALMEAPPPSLKASGQFSQREQLETEVVKLLIQSYFNVVKVETISMVPKCIMLNLVTQSKEQMQKELLQEIYRPDVLDELMKESDHVVARRKECVKMISALETASEIIATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTE8</accession>
    <name>W3VTE8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTE8"/>
    <dbReference type="HOGENOM" id="CLU_619825_0_0_1"/>
    <dbReference type="OrthoDB" id="3366352at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="166"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="442" mass="48621" checksum="6ECA7ABE9B229011" modified="2014-03-19" version="1">MSAPSQHRQPRDHQPSDCVVRVVRLSSCEHQRQRQHHHHCHITPCRCTTPRHEAQNVDPERGPIDKRLTTGSARQTDVAPPHTHSAPSSASASTSHFRSQDHAVISLKHSESKHPRASAPCRSKRGRGEPDSIADTRRESAPSTLGGGASSASADTQAQCWGCCASDATSRQEEWAKVYYVRKDVVASQSDLFRELVQAQQVESGEIGSRTARMIEVALTLPDATSFGVLLDYFESGDFGRISSAMESGEARWESVMLNARHLRVSEVLKMQLGAWWRHQQGRMHRGSLPASAVPPPHATQAHIFEPSSSRSGQTGARPRAYTTGNGGRPSLHDRLSESKRILTPSRALVVASPSKTSPEPTHTAKRTREGRIRSTPRRDSRPESLYSVVRAEPRARSPPPMRKARPAALQATLSKRPRALSSLAYYCSVAPESKMAPTLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTI4</accession>
    <name>W3VTI4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTI4"/>
    <dbReference type="HOGENOM" id="CLU_074896_0_2_1"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25186" checksum="6A5780A10123D85D" modified="2014-03-19" version="1">MSNQQGASGSAAAGAATDEQPSPQQLLFAKSIMLTFELWPAMRLAVSEEWGGSDSADKRDFLLSHLCDQYGNPGSAFEPDLDDLADILEGYMIDEYEARLEDGSPDWVAGRIVGLHRVIFSPDNDIARAQQAVAELEKAFQELKGKKSNFEHGADQDAEVDSHDGHDHDEDQQMRDAQRMASSQGGIMEADRAGAQAALDQQARAPREPQQPIVDEDGFETVVSRRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTP1</accession>
    <name>W3VTP1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTP1"/>
    <dbReference type="HOGENOM" id="CLU_008455_0_4_1"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="219"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="687"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="739" mass="80766" checksum="1DA3AAC1F8C8D524" modified="2014-03-19" version="1">MSSQSRSSSQHRPHQAPEYLGADQPQLSLQPPSTSQPPSRHASPPSSLKARSSSTSVTRLGSSDHLAKSSASTAPKRTRDNAPSSSGSSSRSSIDNEEHADLPGPLPTSHALQPLASRLTRSDSRPKATQPTDPAIAGRPRSASNRSVSYIDPANKPSDLARASSRVSSIHRCADPHYPASALALTLTKSEDPDAVYIDWPENDPENPFNWPKSRRWLLVSVCFLFTACTAFNGCGYPSASFNAAQDLRTTQLVYLAGNTAFLFAVSITPLVLAPLSEVYGRNPIYLSAVLLFTLLYIPQALAKNITTIIVVRWFQGMAASVGNSMVAGSVSDVFHASERGFPMSLYAIAVYIAQGVSPYISSVTVNRASWRIMFWWQGALALLTYVLMFVFLKETRGPVLLSRRAKKLTKETGKLHKCRADDERLNFLVMVKVSLVRPMQYLLFEPVVLSFALWIGFLWGIIFISLEAIPIVFAGYGWNAEQQHMALLTIAVGGTIGYLVNFHQEKLYAATARRYGGKPPPEARLYYAAAGAVLAPIGLFIFAWTGRVGISPAAPIIGLTIFNLALFPVYLAVFSYLADVYERYASSALAAQSFLRNTFAACFPLFSQQMYEKLTPKYASTLLAAIACVLGVVPFVLIKYGDRIRSHSRAALALQREEQEAAEWRQAEQGKQARREARRLARAARQAQVGSAEVDEEKILDTTDGEESGAVTPDAKVDASQDCDNCNNPNFRPPTSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTT8</accession>
    <name>W3VTT8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00874</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTT8"/>
    <dbReference type="HOGENOM" id="CLU_453499_0_0_1"/>
    <dbReference type="OrthoDB" id="10035502at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834574" description="cellulase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 45 active site" evidence="11">
        <location>
            <begin position="31"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="548"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="602" mass="64115" checksum="17C882CE290EC7AB" modified="2014-03-19" version="1">MASTMQKSTMLVAFVVAATTAIWTPLVAANAATMYYDCCKPSASWPGKANPVYNPVAVCFADGKTVVTGPQLNDAKSSGCGGGNQFQCSCQQPWTDHANPELGYAFAAMTTQTESENACACYVLDFAGAKPGKVKTLFYQVINTGADVGGGGLDILVPGMGIGLMTQGCPAQFKTDISVWGKQYGGLDHDAAGCHKLPADLQHGCLWRMNEWGDSVNMAGQPRRVKCSQAHIDRTGCQRTDEKNVPSFEQAFASIRHGGDANAAPDRYIPNAAVCGIGHSGRPVARRNYVGAHSNSISRSTSHGSSSHQSSSHQNVVQKQTSAGDNTATPLIASPTPHPLSIPSVELKALRSKSGGTAATQSFQGDTSFALARIIGRKLYSRLSRPLLGLPHLCAQRATEPCHQVEIYTSVRILQSGIEYKKATGGRYFCPSTLSAPLIHLRLPTSSSIFDIVSTFVSSTIALHSHRSDVASCPIMPAASQYPAILVSRALAELAIFDREGFFALVLDIGDVDALVIRIDRVVEEFVEANPEVAEALIEQATENVKTAGEPTATITELPDLGDPPSPVDSDIDAMMADMMSQLFTRSDQSQQESTQQDGDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTX4</accession>
    <name>W3VTX4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTX4"/>
    <dbReference type="HOGENOM" id="CLU_061288_2_1_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000398">
        <property type="entry name" value="Calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="189" mass="21271" checksum="A5D3CF32CC490B07" modified="2014-03-19" version="1">MLRGRPVTTRIGICKQKCRMAKETDRIDFAFGLVCRPNAIMADQLTEDQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMVNEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIKEAFKVFDKDGNGFISAAELRHVMTNLGEKLSDNEVDEMIREADVDGDGQINYEEFVNMMLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTZ4</accession>
    <name>W3VTZ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_00418</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTZ4"/>
    <dbReference type="HOGENOM" id="CLU_023995_3_2_1"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS64975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="472" mass="52371" checksum="6DF325F7CBC175A9" modified="2014-03-19" version="1">MQLGAAAAGANPEAGQPRKSTAASRKSAYLKIGDANPADLQKTRSCLEPLRPSKAAFGRWLSVAFPHASSTLSPTAISLRSLWLHRLPSEMWPRHPASETAGQRAQAHDVDDRPLNADEKTPADATATDKKRSSDAINKQDVIRFAPLSIPRSRRLQTAGVLFWALLLPICLSIFFLLLSIPYAWPILIPYLIWINFIDDAPENGGRRFSWVRKLPVFRYFAEYFPISMIKTTNLPADRPYIFGYHPHGILGVAAVANLGTDATEFPESFPGITPHLLTLATNFTIPLFRDCIMAMGLCSVSKRSCEAILRKGKGSAIAIVVGGASESLAAHPGTADLTLRRRLGFIKIAIRNGADLVPVFSFGENDVYEQLSNQEGTKIYALQKRFQSLFGFTLPFFHGRGLFNYSIGLMPYRHPIVSVVGKPVHVKQNPNPTKEEIEEVQTRYIEELMNIWETWKDAYAANRTKELTIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU38</accession>
    <name>W3VU38_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MAF1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU38"/>
    <dbReference type="HOGENOM" id="CLU_037043_3_0_1"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="58514" checksum="E10D34B2B4DB9230" modified="2014-03-19" version="1">MKYLEYPELELLSRALTFESAECKVFTRMEAYSCKTVSKEKRLLKNLESTYLNSASTSPPDYLEEALASPFGRLDQASARKTLFLLIATLNVAFPDHDFSEVNPADFRKESSPAMVLNSLSTTLLSLKTSSNAPRSYSSFPGSFEEPGFALGSTGGSPGSGLNTGSLPPLITHPALSHILDDIMNVSDCEVYTFHPDMDSDPHASAEPEEEGDLGDDDPYDDEEYWDDDSPGMRGREDTPRARTMHADDDEEMVDAPMFDEDVYGEGLGGAKKAPQTIATIGPDGNVVLSRGGLDTKRCPSMESSSLASYSSYHDSSLNDEEDDLDGTGAGLLWSTFAFFYNRKMKRILFVSVWSRKNARFGLPTSTWAYAQPPPVLSASLGSPHGHFGRFATPASAPARQRASSTSKKQQASVAPTAAAAPSLAKRAIARTDSTGSLKRVGRPGHIRASSGSPAPSSLSPFPHASPRAVRTTDPMENVVIVDGSRQVPSLDAALLSASAPAGASAAIGTGLQAAMRPTRTSVRSKRASDTSTSTFDQKRVKKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUD3</accession>
    <name>W3VUD3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUD3"/>
    <dbReference type="HOGENOM" id="CLU_019754_0_0_1"/>
    <dbReference type="OrthoDB" id="3366471at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="787" mass="82302" checksum="8278F11789C045BA" modified="2014-03-19" version="1">MTVAVDSGSTSATMAAASVSDDSAASNGAIEPPDSVQAVSAGLCSLAISSAHTSPSKPRHSASSPAPAPALGASYPPPTSASASRLADRLHHPSSGHHPTGSSYSTSPASRHGRHFAMTNSASVDSNLSYDGLYPVPASPSMSEALTDSPGSVSSINSFRRGDLADIEDLDLEPELETVSECDEESSSLCSLDIGVDLDSDSERASSHGGDAESLSNAGFPLGLASSHSARHTPHRPASHGTAASDYARRKRSEWLLHNYANKIAARRPRRIKKGRITEIVEEGGECINTTVMPKQSLASSPSDWSCDVSGPPLAPPRSVSPSDTVPAVPSPLCSCVSADANPAPTGLEASVETIKSDPTATHLALPAAEGAAAHASAMPPFAEGRLAPSSVDQIDDGSIETASQASPPRLSRTSSRRNSSPVKLRPCFRRQPSQQSAASTRESSCERDPPRGRSVRFSSRPPQELRTHSPVEYDRKSCPVNNRLSPADVEELRTMKMEMGLLEARWAAVAACKPKKVAGTEGTTKPENYNAYNAGIAAMSASRERTPACGAESDSTLGPGSLGSAAARLRQQKERERLQERQRNLPHYLRNRSSTVSSPAESLSSEALSIRSKFGHAPPPPLPGTPAARAASMSPSRSTSVPPGQRLGLEPGSAPRRLSCQSIPSSHRPEIPVLTQTSPSPPLSPLHPRTNFDAAQADASKAADRSESRRLSATSLPERGRSTLCATPGSASPWSNGPASATSSIFSSTYFPSAPPTPCASYPGGNGYDSPASEFYESGSEYDMVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUE2</accession>
    <name>W3VUE2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUE2"/>
    <dbReference type="HOGENOM" id="CLU_021993_6_0_1"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="61791" checksum="B606FA00BF23B94A" modified="2014-03-19" version="1">MLFARGSASRVSYKALAGFDERVRTIPRLNLSPLFSIQPLPFDIAVMSLREASVDLPAASGMRSRAAAGPSASASTSASLRPRNHGPIRRAFKSAFSRFAAAPEGSDAQESKSTFLKEASLYTCFLLAGWVDATPGALLPAIREHWNLSFVLVSMLFVGTFVGCIIAAAFVSPLMDRFGFGKIISVAAALGLVFPVVFLTMPPFPVLIVAMMFSGMSNSSLDALVNVWISQRPRSDVRLGVVHFLYGLGALSSPLAAIPFLHEGRKGIAFQYFFCVSLALALAVLTMVTVAFKLQRDELVEGPAQQLATDDASIELQPRTATQVSDSADDKDKAIPPTPGSSSHAPLELMPIPAPVEDTRSGMYKLRAVVKQQKVQLLALFTMIYVGCEVTVGGWTSTFLIEVRNQETSANVLVSGFWAGIAFGRILLIPLTAWLGDELASLIYLVCAVGLQLLVWLVPNIIANAVALALLGIFLGPAFPIMIRVASKTIRPRAHLTAAISFISSFAAAGMALLPLLVGLASQAAPQGIKVLPPILVGLLAAQVGLWTLTNRSHFKQRFFSRRADGGAAEHDEDRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUP2</accession>
    <name>W3VUP2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_01007</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUP2"/>
    <dbReference type="HOGENOM" id="CLU_010189_6_1_1"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="84"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="349"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="582"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="593"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS64542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="70945" checksum="87312F9B89A82170" modified="2014-03-19" version="1">MKKNEPASPLKDDDALRSQPAQDASSSSYQPSGSEGSASAKGSSDLQRPVSSTSTVADPSSGSNSLISSMIADNPIFSGGLGLMVFGGAVAMLRRGVKVAASTAQRRLLISLEIPSKDRAHPWFLHWMAAQSRAQSMRERGLLGKPKKEGLVDFLGLRDRSGEQRPGSSSKGGVDNPLMIASSGSLVSPVRILSHELSVETNYTPHASASTSNAEERGKASFSLVPGPGTHWFRYRGVWMRLTRERDGKMVDLTTGAPWETVTLTTLFAYAHLFPQMLDEARQLALSSTEGKTVIYTSWGPEWRPFGQPRRTRELGSVVLGRGKKEAIVDDVKRFLERDRWYAERGIPYRRGYLLHGAPGSGKSSFITALAGHLDFNICLLNLSERGLTDDKLNHLLSNAPDRSILLLEDVDAAFLGRQQAAEDGYQASVTFSGLLNALDGVASGESRIIFMTTNHIERLDPALIRPGRVDMIAELGDAEEEQVVELMMRFYRTTMREMALKSLELPPAAIEAAKPLLTQAAEATDHASTEIAYKSLEAVAGLREAVEQTDARLSQLANEFGQIVVAEAQQRRAAVGLGLDGRPLAAPAPPASQSNPDATGASSTTDLQRALRPAPAASGGVSMAELQGLFIRFPDDPQAAAKAFMGENAWRRTPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUX7</accession>
    <name>W3VUX7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUX7"/>
    <dbReference type="HOGENOM" id="CLU_047470_0_1_1"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="321" mass="35271" checksum="B8F59D58D11C2C67" modified="2014-03-19" version="1">MSALDSLKQYTAVVSDSGDFESIDAYKPQDATTNPSLILAAVKQEKYARLIDVAVQYAKEQTSDKAKQLDLATDRLLVAFGVEILKIIPGRVSTEVDARLSFDKEATIAKAKSLIALYESLGVKRERVLIKIASTWEGIQAARELESQHNIHCNLTLLFGFNQAVACAEAGVTLISPFVGRILDYYKKAEGKEYASHEDPGVLSVQRIYNYYRQHGYKTIVMGASFRNTGEILELAGCDFLTISPKLLEELKNAQGPIEQKLSVDKAKAAEKIPKVSYINDQPAFLLDLAKDPMANTKLAEGIAGFAKDGATMEQMIADKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV27</accession>
    <name>W3VV27_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV27"/>
    <dbReference type="HOGENOM" id="CLU_315010_0_0_1"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="655"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="860"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="936" mass="100249" checksum="AF16C7D300E68E34" modified="2014-03-19" version="1">MGITAGPLIVMSMDEFGFLSEAGHSSVQPSYASGSRGAPPLPPTSSQRSYNYAQQDPWRPENQSQPYDCDPRARHLSIQARPVHAANPAPGSSLGSEVAEEPAVRAKRGSNLACLKCRAIKVKCWKSNPNDPRCARCNRLDLFCEFREHHRGKKLEKVIADESRNVVLSPDLLRRSCEYVLACSSYPLNLSLASIGNPQGGAHMAAFQHYRGEGSIQDSLSSRAIGMGAGDVYDDVVRTGACSWTDACYVFSLFVTQLNPVAALLEPSVHTVQFMREQSPILFSTILGIASRFFRPDLSAACEAAAAGVLKCAAARKICSVDHMQALVVCLIWAAPGDTTRDEMLASALAQAYELGLPLCFDAGVPVGATTKQYTPPMAPHMHAGYQATVLRMQQRTWMQLCLLELSQQSDAHGSWAKRPERIAHADFPRVRAWYAQHHATLGAYETRLAYLLDFALVQRESNRLAMHPGALQGYAPDGSLSQNANQLMADERECLTAWFTTYGDEHVPRYGLDRFGQAEASFVVLYYRFSRAVQLHALTGDASWYAAATELAYKTLETFCSKILEQEGGSMLRLGAQSMGAACLAAARWLLGGAGHVQERERARERISEAIRLLRQPQFYPDGNRVVVANELTGQLDQALRSVLGDAGMVVDAGWSGTSPKRSRAQGRAEQLYDSGRGVLERRSRKQARRGSNGSLARIELGGFGGGATGSEPTGSDRGGSEWSDDAAGRSVDAGMNEVYWPPALLGTSGGDAGAWTPRSEGALSSMAMASSISPPTSASSAVFSVQAPSVPDPLDLGLGAGVAGWTYGYADPTASSSTTMGAPATPYDASRMFDRQPQPNEMLSAPNGGPNLHGMFAGETGEPSGTPQAPTLHRNDTATPHSYGAPAAQTDAQLAAAASALDASLTVGLSASYNASHQGLFDGAAHGRQQQQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVA8</accession>
    <name>W3VVA8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00174</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVA8"/>
    <dbReference type="HOGENOM" id="CLU_281882_0_0_1"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000005">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="329"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="989"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS65440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1110" mass="121559" checksum="2848E0E6DA46CF7B" modified="2014-03-19" version="1">MSGFDAGRVFSAQALAGSEASRAPDAPAQTEQTLFNFVQTFRTGSDYIYRDRLRANLLARQYVLEVQLEHIQLWSNDLAQALRDTPSDILPLFESAVKRAARAILYPVITPGEPRPDAPDCQVTLRSHANLTPMRDLHADSISHLVRVPGIVIGTTTLSSRATHIQIMCRDCRATKSLPVVSGFGGFTLPRYCDSTKMDTTAPQCSTDPYVILHDKCRFVDNQTVKLQEAPDMVPVGELPRHMLMSVDRALCGRVVPGSRIIATGIYSTFTSAKGGKGSKAGAIALRTPYLRVVGLEIDAEGAGGRGMARIFSAEEEEEFARLSRSPELYEKFSASIAPSIFGNQDIKKAIACLLFGGSKKVLPDGMRLRGDINVLMLGDPGTAKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPQSREFYLEGGAMVLADGGVVCIDEFDKMRDEDRVAIHESMEQQTISIAKAGITTILNTRTSVLAAANPIFGRYDDMKSPGENIDFQTTVLSRFDMIFIVRDEHNEQRDRTMAKHVMNIHMNRANDTTATGEFDIEQMKRYISFCKSRCAPRLSPEAAEKLSSHFVALRKQVAQVERDNDERSSIPITVRQLEAIVRISESLAKVTLSPTVGEEHVDEAMRLFRSSTMDAVQAGNVEGMTRGELAEECQKLEREIRRRLPIGWSTSYGKLRHEFVESQGYTNHALERTLFILEKRDVIRFTNQRKMLTRTGVVYKGFETGMHVVTAHAEEETGFGAIADTVQPLPSLPHAGASNCHRLIAAPTPAAARIAEALTLLCRWRDKTDALRLWHGSLVWRGFGGTPEMARSARKSECGADRSIILAQRSSRRSCFPKVSKETRHAFTASCPFSSGLVHVEACRLLQAALQSSVGLFGGLCTGLTPQSSISNRHEEVPVPYQGATFRAPSSLPSTCSVSGHIREVQSAGTRRPRWGALEQRVPTHPRPRLPPAACSVFSLLPPAAAVSRLSPLDLKSPGSARSHPRSGAGSGPFFCTSRQGRRATAGRVAVVRISIHRLTILSPRGVGHQSASHVHHLITITATATVYSSTPPLTAYRRELARDQRGLLGSNRIAPFLLRFSSRLYAHTSPSSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVR3</accession>
    <name>W3VVR3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVR3"/>
    <dbReference type="HOGENOM" id="CLU_051033_0_1_1"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="6">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A C-terminal" evidence="7">
        <location>
            <begin position="137"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="249" mass="27380" checksum="C61C3EE69805B0B9" modified="2014-03-19" version="1">MVAGFAPKRASNNTLRPVTIRQLINAEQPHPDADFIVDGAELGQLTFVAVVRNISRNATNIAYSVEDGTGQIEVRQWLDSSSDDTQKVSEIRQNVYVRVLGTLKSFQGRRSLSAGHMRAVVDYNEVLFHRLEAIHSHLQITRGTHGAPGTQPDVGQGLIRGQPNDIGAYSGSNAQNVLDQYQSLDELPRRIMGIVTQEAENHHDGVHVSHIARMLRNVDIAQVRSAVEDLSSEGYLYTAADDDHVLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW30</accession>
    <name>W3VW30_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">PaG_00439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW30"/>
    <dbReference type="HOGENOM" id="CLU_034595_0_0_1"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000657">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="225"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="308" mass="33400" checksum="1F737A7FA5763688" modified="2014-03-19" version="1">MAPVAAPSTSQPAGGKPMNWADEFDEDVSGDAPRIEERDEGNGVKVVIEYRTNADGKKVKITRRVKRTLVKTKVNHEVAERKSWTKFGKEKGNAAGPHSATTTIGENVVLKMSAGNKTAEPEVDEMDKVRQQLANKRIVCRLCKGDHFTTKCPYKDTLEAIPGAGADTPEAGEGSMTPLATMDPSNPAVAASTGGKYIPPSMRGGAKGPGEKMGGLGGVSRDDLPTLRVTNLSEDADDDDLRELFGRFGRVVRVYVGRDRETGICKGYAFVSFETREDADRARQKVDGRGYDNLILSCQWSLPRGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW37</accession>
    <name>W3VW37_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature requirement A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW37"/>
    <dbReference type="HOGENOM" id="CLU_022899_2_0_1"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="83545" checksum="258DA19A24988A44" modified="2014-03-19" version="1">MSNFHRPFRAQQQADAPPETAIHDEPEVIDPNLYGPFGHRYHDSAVDVPHHADSSHAAHPSTTSWHDVETSEQHRHHNNVAHAQPVDPQLQTAIPLGDLSRNHSATQSISDASQRGFVTHAAPMAVEYTQDSRFTVRSSFEKPPIGAGSRASHSHLRRRSKGFGTHHSRAGSLFDLVHGKERSKMSDKPHIEVHGEDVPITVRHLIKRPIIRQWLHGNKLYRERDERKPSQFELVFDLIFVAVVNGLGHATAESSSAINVLKFALSFWPCFSLWTDVRLFLNTSGTDDMLERLLMLGWMILLGGYCANVSGVELIKATPELLAQLHSEEATGEASSQMNAHGIVQELESIFRRAASADSAGAEEVKLAVPAFGGYWFTEGYNRAIHAAIGFFLVSKLWRLGIYIYYGFCLPKFRKALWLNALAMTVIAAIYIPITLTDSPLLILILMGAGIGVELARAYVVAAAIKLFHKRSKRTGNHMFIPAQSHEHSIERYVLFVILIVGESIISSNFVARPGSFGLNHEFGRMALGITISVLVIWIYYDADGSRVYQHALRRNSFTSITFGHIHYPLTASLILMAASLSALISNTKIKGGYVWYFGGSISCVMLCLGLIGMMHRNLDVYRSTLVPRWARITVRFLAAIEFGLLPLKSDWKSLNLLGTVAASLAAIVLFETLGKVGAVGRRFDADKSQELYANMSATGEKKLKLDRRASWHPFDDLTPGELGEEDVGIESEIGHLEEKDLTHGQRWAYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW82</accession>
    <name>W3VW82_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW82"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833338" description="Thioester reductase (TE) domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="8"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="349" mass="38077" checksum="E84E4904EB30A227" modified="2014-03-19" version="1">MAGPLVLITGITGFLAAHVLDAVLASPANYRVRGTLRSLSKKDALLARLSAEDRSRIELVEVADTATSDLLPAVRGVEIIHHVASPYQLNVQDAERDLLIPAVEGTLNLLRFAKHEKSVRKIVITSSFAAVTSLKEGGPNRPGYTYTAEHWNPASYEDALEAGGAGAFSYSVSKKLAEQAAWDYVSNEKPHFEIAAINPPMIYGPTLQPGVTLANLNTSSKTIYGLVAGADQMPEDRLPLFCHARDVGDAHVAATEKDGGMGRRYLLCGGKFTWAHAVGFIAAEYPQLQDRLPKGWKEASESLRDLDSIASLDTKPAEQTLGIRFRDWQTTLRQSLDSLLELEQRADWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW95</accession>
    <name>W3VW95_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW95"/>
    <dbReference type="HOGENOM" id="CLU_031466_0_0_1"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="213"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="553"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="558"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="603" mass="65325" checksum="CE42EAAC5409477E" modified="2014-03-19" version="1">MAGQKRTRSNDAGGPSKRGGGSATVYRKSAKKQRSDSQDSPKPVKKAVPQRTRPKDQPKPKTKHEFIQAKKAAAAKEKSEADAARRAEEAAEKKLRAKQKPTKGKASNGTSPPASILIKPPQPTSTFKIVAGSYERLLYGLEATVGPADASSSASAAAPFRVSLKPIFTFPAHISSIRTVATAGADSKWLATGGTDEVVKVWDLRKQREVGQLTGHEGTITSLVFASRTYLLTTSADSNINLYRTRDWALLRTLKGHIGRINSAAPHPTGRLALSVGSDRTIRMWDLMRGQAAASTRIGIEADVVRWDTTGARFAVLAYRQAMIFGTDMTKIAELEETRRIGDLCFLRVKDEDGKEHELLLAGLEDGIVKVFDLDAQVEQPAKEAKAAKEADSDAEESDDGEEEEEELAPLVEVGRLVGHKNRVRSIAVLPVKVSEGARSYVAVTISSDGFIRTFDLSSIVNKLSGDRRPLEAYAGEVVSVERVAEYDTKGTRLTCLTAVGVAGGASADAEEEEAEEEVIGSDDDEAEESDEVDEQAEDDELKALERALKDAQAQGLDLEDLEALLDGEDEDDDEADEDDEDVSIEDDEDEAEVEDEDEGELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VCV1</accession>
    <name>W3VCV1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VCV1"/>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="529" mass="55907" checksum="7FA210EE7318D985" modified="2014-03-19" version="1">MPTLNKISFGAAAAAVAAAVLVSSSAAFPLYSVHGDSSWMARADNTSLESCLSSSGGFEQAYASSGDYTALTSSYNPLFSYKPLVVAVPNTESEVASIVKCVAAHEGRQKLSPKSGGHSYEAYSLGGQDGSVVIDLSRLDGIQVDQANKTAAVGAGVRLGTLAQGIWEQGKFALPHGTCPLVGVSGHALGGGFGYTTRAWGFLLDRIQSMRVVTSKADVITVSAEENTDLWWGLRGGGANNFGVVTQFTFALQDAPTQTLNYNYAYATNEDCAKAIVAIQDMSNDPDTSTGLQAELGGELLVAGSAAGDFDGNACQLAGQHINTAREAHDALMARLHTRAGVQPATTSVKPFDSWIDALTDLMGNLSATGPQHEQFYAKSLVQPTTARYSYTSALALVSELNSYAGLRGTGNSISFDFLGALAYSAKMESASFNAHGATLINQFYSYGFPSNDDPDAQQDVWKAFDSLVQTAKASAPDADWGAYVNYVDARLDDWAHAYYGAALDRLKQLKSTWDPQSVFDFPQGLAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD56</accession>
    <name>W3VD56_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_06500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD56"/>
    <dbReference type="HOGENOM" id="CLU_002125_3_0_1"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="298"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="539"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="726"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="375"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS59578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1150" mass="127070" checksum="8FC5B88FC3E3ED47" modified="2014-03-19" version="1">MSHHHTGEGWSDRNPVPTVQQYRDQQEQLRAATAHDNASKLASSEADEAAPVSASGAAPAIQGSLDGLRQRKSTSTAPGQATNGASLDSTNAASVDSKASRPPKEDDVDQAPGGGAEEKERIKKAYAPKGKANEFEEKGERIVTDPTTGGEVQIRDASENAKIDPDKLDSRYGPGFSSHLPKDPSKHHPLHTSPNPAEPSNILLHRFPEPVNTEAMKRMQAAFNQLAIGLGASLAIIWFFVAFGNGWWRFFLRTSVIAAVGFAGWTGLHLQTRKIEKEHEAIRAEMHKQRGQQLSPPMPESVEWLNAAIACIWKQINPDMFVPMADMVEDIMQQSLPGFVDAVKIDDIGIGDNPFRLVAMRGLADMMSDKEYPREEWITQGKQVPDNEQDKKSDAKKALDANEDADGDGVADEDESGDFLNYEISFSYSARPGQSNKDRAANIHLMIQFFIGAYDLFQIPLPIWIQIEHISGTVRLRCQMVQQPPYIRNLTFSLMGVPKVEISAIPMLKALPNVLDLPLISGFVQSSIAAAANMYVAPKSMTLNMAQMLSGDGIKKDTDAVGVLVVEIEYGEGLSAQDANGKSDPYVVLSFAKFGRPLYSSRIIFEDLNPVWKETAFLLVTKDDIRANESLSIQLWDSDARTADDIVGRVNKPLKDLVRDANHPQDRKDKLMGFEDADDMPGTLKWKVAFYEKADFNKALVPKKKQEEMTKVEKETQREASAIDSAEEATALHCPPDPEYPSGILSIIVHHISGLENRDVEKGVMGKEREGSYGQDVDAAAGEGKALPSGYVEFIVNDDIVYKTRVKQYTNMPFYEAGTETFIRDWTQTEVRLAVRDARLREHDPIMGIVAIDLTELFSESSQVSQSFSLQDGVGFGKVHASLVFRSIKAQLPKALLGWDTATVELLSEIEIEGDEKLKQKKIKVSTGDDTKKVHPDQHIEAGEKTLVRLPVYDRYSSLLTFDLGGGGLSVGPLGGKPDAVAVAALCDLPDGEVVDLELDLMAGDNLGTLKRNYINEQTRKTHPFEVVGKLRVKVRMDAGLDDDHLRLVEHSSGRKDRHEFEVYNRLEGMPNRAVQNSHAADDGVIDRKEQKQINRAKSEALHSRHRGVMGYGSARSAVWAKDGIRSRIRRTTDKIRGKKGRDQTIKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDZ1</accession>
    <name>W3VDZ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDZ1"/>
    <dbReference type="HOGENOM" id="CLU_021860_0_0_1"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="187"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="717" mass="77832" checksum="218E3D15DCE09382" modified="2014-03-19" version="1">MLSTTTSTATVRAAWRPFSTTALVGAASSSSRDPAAFWTSDERLIKALRRRQEAYRLSQVGNSARKTSDRIEAAQLANAEVRWLVQHVRKLQTDTAASKSSSRQNLDRASRRRLVAMATQMTRANVPLSYLLGSVPFGSLPVELTVRPPTLLPRPETEHWATQVVADLLRAIEASSTAGSSALTPIRIADLCTGSGCVALLIAHALRSKLGDDADWRVVACDRSPLAVQLARENATKLGFSEHNVCTVEADVFSDADMDGLASIVGGPFDVVVSNPPYIPRREWQALSAEVKAHEDPAALIGERDVSPATSDRVTGQDPVQDGQGDAQRSFVNRTGLAFHQRLAELLYRPSFAARDSKLRAHGAPRLVAEYGKGQQRLVAKLHADLVAPADRMPRVVRLSGHQLVVVGVGNATTHPLTRHSIGQVVLDPLLARLVAHDAQIRRHLAQARERLEQERAEALASGRIDPQARPDWAQPVPARLPLSCASTEGQYLDPNDSVAMPSELTKVRAGKSGGWAATIPLLVHASDCSSDVYQVEVSLYKPSQAMNLSGVGLRAFLTAHHPNPTDAAVVDDTLVLQDDLDVDFGLVKAKSTGSARGHNGVRDILARLNVADTKLARLRIGIGRPPAPTKEAQNEWLPRVRAAKAVPVDKWVLSKLTKDELASCTAQDGEVVGQVEKATLKWIQQRCSELGAEDASEQRLAMRKDQFGIHRSVWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE08</accession>
    <name>W3VE08_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_06194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE08"/>
    <dbReference type="HOGENOM" id="CLU_008535_1_0_1"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="845"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="654"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1109" mass="118911" checksum="98F9B5051F7CC3C1" modified="2014-03-19" version="1">MCSPNVHFEHLIGSSNTSPAAPSQPFRSLSHARTAGASSWRSNIGAADASNPATSTAAPLSHTINHHSSVLSLAVDERRNLLYSGSQEGCIHIWDLETFQPAARLQGHTGSVLALELAPEKRWLFSSSGDNTIRVWNTDTNAPLFVVHPAEENVGDIFALKWCAGLETLYLGCQSTSIQWICLAGFDKQPGPSKRLDANESLAPHYDVGTASLGFNQAGADSPIISTPDIVARPHKFFDSVPVALSRSGLGSAGSSTPARVRPPSSAPLKPSKATTSADGPQPTEPDTHLSDKGPLSTTRATEKVLHAASQRLDSTAVRDEVARDDSGGSVRTLLVPPSSAVPSAHFGYVYCLALLTLEGDAQHPTVLASGSGDETIKLWHATRAGLSLLATLESPNADGNAVLALASWKTTLFAGLQGGEVEVWDLETCTLVRTIRAHSDDVICLETCAESGLLFTAGADGNVHTWDRSFRRINRVQAHKGIVLSMTKVRTPAQSGEAARVAQLVTGSSDNFIRIWDTTPSPALPSSSREPVAELRRRELEHLSLEEPATPSLSSTPVASSSAAMTRAQVTEEGETPEAVSAQWPLLRSLLRRFIAIPSISSSEEHREDCRQAAHFLKTCFQELGAEARILPNPVGTNPLVLATFKANAYRSRRRRTAASGANDRSRSASTSASASTASTSSSESRTVDNDDDDEEDAQGLSGSIMFDHLDGRDAAADADEARTSRARPQKRCLFYGHYDCIAAEGSWASEPFTLDGRDGFLYGRGVSDNKGPILAAACAVHRLLSTRRLHSDVVFLIEGEEENGSVGFVEAVRRFKSEIGPIDVVLLSNSYWLDDETPCITVGLRGVVRATVSVGSGERDVHSGVEGGAIREPMVDMVKLLAALTAEGERVALPGFYDAVRQTTEDEVQAYRDIVHIKQHAGAHADTVESLMAKWRYPSLSVHNLRVSGPGNSTVIPSSVEAQVSLRIVPDQQLAQIEASLRAYVASTFDALYATPASATGRVVRNKVCVTVDHRADWWLGSDASVYFALLRDAVRHEWKAEPISIREGGSIPAIAILEKELGAAAVHLPMGQSSDSAHLPNERIRQSNLVKGHNVVMRFIAGLAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VED5</accession>
    <name>W3VED5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_05994</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VED5"/>
    <dbReference type="HOGENOM" id="CLU_029244_1_3_1"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="407" mass="44811" checksum="4FCCA3D19CDB2F52" modified="2014-03-19" version="1">MASALRSSSIAARRAGFCRAAGPRALSTASTASASTSQASTSAPTSRPRVIFSGIQPTGIPHLGNYLGALRNWVDLQNASRDTSDELYFSIVGYHAITMPQNPSRLRTERSEMMATLLAIGLDPQRCTIFHQDHVAEHTELAWILNCLTSFGKLHRMTTWKAKLATARNVSDTTEVDDKDLSLGLFAYPVLQAADILLYKATHVPVGEDQIQHLELSRDLADVYNRRFKRTFPLPAHIITPTKRVLSLRDPTSKMSKSAPDANSRILLTDTPEEVRRKVRKAVTDAEVQLGYAPEQRPGVSNLLAILAALKSQTNAVGTVGMEHAGPEEWAERLNQEIRESGASSGQHLKATLTDAVVETLRPIQTELERLRKDPGFLTEMEQLGKQKAQSVARRTMSQVRKSIGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEE9</accession>
    <name>W3VEE9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acetolactate synthase</fullName>
            <ecNumber evidence="11">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_06009</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEE9"/>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_1"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="134"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="350"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="558"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS60018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="741" mass="80373" checksum="F4E3F8659DCA0C93" modified="2014-03-19" version="1">MTSFAVQFARQQRHAFQAASKLSAASSTSNVIAAAAAAASTSYASTPSAARAFSTARNNLPRSAHFARSQRTNLALTRHISTNQPKEQAAAAAAQTSASVRPEPSPAFQQSPQNIAPLSSRYDANALDESFVGMSGGAIFHEMMLRHDVKHVFGYPGGAILPVFDAIYNSKHFDFVLPRREDGAGHMAEGYARVTGKPGVILVTSGPGATNVITPMQDAMSDGTPLVVFCGQVATSAIGSDAFQEADVVGISRSCTKWNVMVKDIAELPRRINEAFKIATSGRPGPVLVDLPKDVTAGILRQAIPYSQTQPNMITSLPSRQVARNRRGATFQQQNSNVRSSEQDVLTSELKEAARLIGIAKRPIIYAGQGILSSPEGPKLLAKLAKEHNIPVTTTLQGLGAFDELDPLSLHMLGMHGSAYANLAMQDADLIIALGARFDDRVTGRIDKFAPHARAAALEGRGGIIHFEVMPKNINKVVQATCAVEGDVVANLGKLMPFLESQGPDRSEWHQLIKTWKDAYPFTYEPSKQGELMKPQEVIEALDAAVADQKENVIISTGVGQHQMWAAQHYRWRHPRTWVSSGGLGTMGFGLPSCIGAKVAAPEKIVVDIDGDASFSMTAMELATAAQYDIGVKVLVLNNEFQGMVVQWQDLFYEKRYSHTEMHNPDFVKLAESMGVKAIRCDNIADLPAKMKEFIEYDNNKPILFEARITKNEHVYPFCPASAGLHELIVHPSLKPIPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEG2</accession>
    <name>W3VEG2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phytase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEG2"/>
    <dbReference type="HOGENOM" id="CLU_020880_0_1_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832896" description="Phytase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="64"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="229"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53300" checksum="C12C3F068CDA78F2" modified="2014-03-19" version="1">MKQLKSALLALASTLGYGSSLWPSTQHGEPVDPNILTNFGAWSFYVPGGDVGRYDISDKSFPGCEVDQVNLFMRHDFRGPSKGVGSGIATMISKLVNASTADNANLKFSLGDGQLHPELEFLAKLNETYSAVTPELLTPYGEQDAHSSGYRFGNRYGHLLGKKDWYNAPVNQSLPVFARTTDQSRVNVTSWAFSEGFLGLNWRERLAAPLLTLPDSLSTYNDSLAVGTCPYSANDTSSDKAFAAWNSVYLPKVVSRLQRALPNLNLTTSDVQAMQNACPFQSAYLGRLSPFCAIFTLREWELYSYGQDLQQYENAGYGGPLGRAWSVGWVNELLARLTETRVKDHTTTNATLDESTATFPLGLPVYLDFTHDTQIASAIAVLGLLKDQISPSSYPREDRLWNSAHIVPMGARIIVERLKCENKKSKYVRVLLNDAVIPLSGLKECNSRSQGRLHASAGLCKIEDFVESQSFAQAGGDWNNCFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEQ1</accession>
    <name>W3VEQ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit tim23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEQ1"/>
    <dbReference type="HOGENOM" id="CLU_063935_0_0_1"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="38326" checksum="BCC6F77879DB5DDC" modified="2014-03-19" version="1">MLIRPGSWQPVLCLGSLTKAPPNSPVSKSILRESGCTAVPFPFQESARALVIHSTDSLSLLHPTPTINPAHCSRPLYLHRHYQEHIHIGTRLRATPDQTAPSFSSSSASTSPSFNMVWPFSSNKPADAAASSSTAQSSFEAVAPAPADATVAQNPTSDSPTDYLRSHTFVQPSSPSPSASGSSPEYVPNAASLLGDSSLNLGALSPLAGLGKDELEYLDLTDGAPSSMEGARTAVPSRGWSDDLCYGTGTTYLSGLAIGGLLGAREGFFRPLGVDNPTFRLRLNAVLNQVTRRGSFFGNSAGVVALIYNLVDASIDGVRGKHDIAGAVTAGAISGALFKCTAGVRPMAVASGIMMAAAATWTTAKQALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEW2</accession>
    <name>W3VEW2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEW2"/>
    <dbReference type="HOGENOM" id="CLU_026996_5_2_1"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="170"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="427" mass="48479" checksum="BB443EC62DB73EFF" modified="2014-03-19" version="1">MISAFFIFNQKGEVLISRLFRNDLRRSIADIFRIQVVSNPDVRSPIITLGSTSFFHVRHENLYIVAVTKCNANAALVFEFCYRVISIGRSYFGAKFDEEAVKNNFVLIYELLDEILDFGYPQNSEIDTLKMYITTEGVKSEQAVREDSSKITIQATGATSWRRADVKYRKNEAFVDVVETVNLLMSSKGTILRADVDGAILMRAYLTGMPECRFGLNDKLVLEKNDKNRGKVDAVELDDCQFHQCVKLSKYDTDRSISFIPPDGEFELMRYRSTTNVNLPFKVHAIVEEVSKSKVEYTLNLKANFDAKLNATNVVLRIPTPLNASTVKCQVSLGKAKYVPAENHIVWKIARIQGGGEASFGADAELSSTTVRKAWSRPPIEVDFQVLMFTSSGLLVRYLKVFEKSNYQSVKWVRYLTRSNGSYLIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF51</accession>
    <name>W3VF51_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF51"/>
    <dbReference type="HOGENOM" id="CLU_053371_0_0_1"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="210"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32283" checksum="D05E20E3B895EB49" modified="2014-03-19" version="1">MSPPPSGGKRESAQARLLGSGLSGIAELLVFHPVDTVAKRLMSNKTSGLSMAQVVFKDKATANVSTKFFSLFPGLGYAAGYKVLQRIYKFGGQPYFNDYLTTHHKKQFENVFGERTGKAVMSATAGSLTGIGEIVLLPLDVLKIKRQTNPEAFRSRGFLRILADENVNLYRGWGWTAARNAPGSFALFGGSAFTKEYIFGLKNYNDATWTQNFFASIGGSVASITVAAPLDVVKTRIQNANFESKVGGVTIIKDMIKNEGFSAFFKGLTPKVLVVGPKLVFSFTIAQSLIPFFGKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF83</accession>
    <name>W3VF83_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF83"/>
    <dbReference type="HOGENOM" id="CLU_108559_0_0_1"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20558" checksum="6B4FD57A483B4E13" modified="2014-03-19" version="1">MPNDAHVSTPGAAACISTRSKGMFEVVDMTSVRDVDAATFIDAYAQHLKRSGKIEVPVWVDIVKTGHFKEQAPYNPDWFYVRAAALARHIYLRKAVGIGHLRKFHGGASNRGFRPSHHADASGSVQRKVVQGLEGIGVLEKDPKGGRRISQDGMRDLDRIAVACLEAAREEEESESEEEDEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFV9</accession>
    <name>W3VFV9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFV9"/>
    <dbReference type="HOGENOM" id="CLU_012944_0_0_1"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="891" mass="98369" checksum="487A0C93247417BA" modified="2014-03-19" version="1">MAIAAPKYRNDDVHANASASASGRAAANRSNESSFTAFARVLQACKDLEPAARIDHDDGTALLFAEVCSALGEEALDDAGYVDRRQDLNLEDDDRAAWILEQNTWKLVHALTSERLHRAERGSRDGAEETDTAAIQPYETPLAAIQSIFEASEQLNELRIIREWLQDALEPRHVVEVRKGYLSFTKNRVRAEKRSSVGSGPSSSDGRKPTFGSAASSSFAPKNRGKAVKHLDPDAVSRGEGGLELEDATYEKALLRTLFEYARAGRLDAAFDLCHQTDQSWRAATLRGAMLYHDPALSPDLPDVDRVVGNRNRALWKSTCRKLASNPNLDEFERALYGSLAGELQPVANVSQSWEEYLWAYVNAKLEAAVDVKLDDRHGWWSQEADVELFGDGEHGAVKLAQGASSSSSAAATLAGSGAAGAPKAEVELGSLSGVFDKLSQLQSHSIHLQANDPYRLVQRSIISNNLPELFNRFADNLGDMQTALEPATFARLLRFFAHLILYLRLLSIALPDFACNAILSCYVQVLEVAGETDLVAMYASSLEPQSATRSYANFLRSMDVNASREAKALALRRAEEHSLDLAAVARCTVDIVFDELFPSITSDFDEPLSFAAGGPKGKAGAARMDATKFDVHLDANEEALVRAIDWLTFDPATFADAITQSNALTRLFLSTGRLHAAKVLRERMPSEVVSSVDTLDISMDQSIERSGWDTFFTALEAHVAYKHFWTTRPADAAASNAIQSETAQVPRTDGLSRRERMNWAKALSQVVEQARDLDLVLLQRDWLKMPLSDAEGGLEVERRARELFDIRQTYIPEIVFRLHDMLTESSSVLPENLGMAMRLSEIVADERHKIYLEFIQNGRNLLQDYLLRVREASLLLLNSGGDVFEKATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH31</accession>
    <name>W3VH31_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH31"/>
    <dbReference type="HOGENOM" id="CLU_050172_1_0_1"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="5">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="4">
        <location>
            <begin position="176"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28583" checksum="D687ECEF76C36FD0" modified="2014-03-19" version="1">MSLPDFSQAANLTKLDGYLADKSYVDGKKAAAFHLRHALADLEQASRRTACLGRRSASMTLVHQRAHSPSQADVAVHEALGKAPDADKFAHVARWYEHITSYEAEHKDLTGDKAKAATLLSSTFAASAPAAEEDDDDVDLFGSDDEVDEEAERIKAERVAEYNKKKAAKGPGPAAKSLVTLDIKPWDDETDMKELEASVKAIEMDGLVWGSTKLVAIGYGVSKLQCSLVVEDAKVSLDELQERIIDECEDYVQSTDVAAMAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH35</accession>
    <name>W3VH35_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH35"/>
    <dbReference type="HOGENOM" id="CLU_151392_1_1_1"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9047" checksum="79E00C1EA23176D9" modified="2014-03-19" version="1">MVLGRLMHYAGDALLISTVLAGIKRQTGLRPDIDRISEPTTKGLLEKYLGFGEFVFDSSVAAARASSLFQKDLVDRLQGRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHE7</accession>
    <name>W3VHE7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHE7"/>
    <dbReference type="HOGENOM" id="CLU_032662_1_0_1"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833159" evidence="2">
        <location>
            <begin position="21"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="542" mass="57865" checksum="7BCBDEEF012EE9E9" modified="2014-03-19" version="1">MRGWALLCAGFGMASRGSAASHVSVAGRKEVTAAMHHAPVPAKSPRLRTGIIPTPVQKVAGLDSALTPHQPPTSSVSACTMAGGIKFEHFPCGVDAARIPGRAPSVVMLGSMHAGSRGLATNLAEEGYEVVLVDTTSGSASLSALRKPPTRGEWVSDANLRETHGWAMATNVLSLIDNAGGWNRYTALLTLGLEQEDADVVAALQVETSGKGGLSAYVAYGSQLQPGQAVEAAKRTMDAGLPFTAHVAEDAQLVDALVQAAKSGEIPQSALPFHPELDGFAAELGPVRPTTLAVFTYAVPNEASVWACAFPFSHHTKDYAFSTGMEDSHRSAAAMSYSRTVATLKAAMGPRFPLEQLWDQHTYFEFATRSAARTMRTMVAQPYVNHIACLTGGAGYTQLARFYQHHFTNVSPPDTTLVPISRTIGADRIIDEMVFSCTHTTVIDYFLPGVPPTGKKLRIPMVGIVNMRGDKLAYESLYWDQANTLTQLGLLHPTKSSLDPTVTLPIAGDQVAQKILHPYGTPSNELMPNWPESENKPVPADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHE8</accession>
    <name>W3VHE8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHE8"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="17"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="379" mass="40316" checksum="93E82F20B653E9D4" modified="2014-03-19" version="1">MSNPRTTQAYRLSSFDKSLEGLVLDDKVALPDAEQLAPTAVLVEVHAVSLNARDYQIASATYPAPTTPPAGLIPVSDGAGKVLAVGSAVSTVKTGDRVVTHLSSDWRHGEIGNEMQASALGGGRDGVLAKHVVLDQYNLLPIPAHMDYRQAASLPVAGLTAYHCLLGFPKTVQQGQTVLIEGTGGVSIAALQIALAAGARPIVISSSDDKLKLCQNLGVHKDDCINYSNDKNWWQTVRARTPRGEGVDHTVEIAGGSTLNRALMATKAYGSVWVVGYMDDYKSTKDSGDGLPDTAKAILYSQAQVQGVMCGSYKLFQQYLEAHATAQRNVDNKLASINVLQPLVIPEQVFSFADAKKAFELQGSGRFVGKVIIDVADAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHG0</accession>
    <name>W3VHG0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">adrenodoxin-NADP(+) reductase</fullName>
            <ecNumber evidence="3">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHG0"/>
    <dbReference type="HOGENOM" id="CLU_024722_3_1_1"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="501"/>
            <end position="503"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="586" mass="62647" checksum="2970936D91AB0201" modified="2014-03-19" version="1">MRSSQVVRSAAASTSFASLPPRARVAIIGAGPSGFYAASRLLSRIPYSSAHSAADQPLAIDIFERLPVPHGLVRYGVAPDHPDVKNVENKFASVAQDPRLRFAGNVNVVHTPPSGSGPGVLQYPEAVQLPLDLLSRYYTHILFSYGASAGRRLGIPGSGPGELDGVYTALDFVNWYNGHPGSHDATLQAAPLHVHLAGKQHMSVVGAGNVALDVARMVLRSSTPFLEPGTASERVTSNKAPGLAALEATDVPEPVLAELARSKVRHVDIFARRGPAQLAFTNKEVREMLALEGIALRAPQKQLLDEAGAQLEQLAATEGGGERAQEVASEVRVKKRLLSLLAKGSKTKHAEDGVKSWALNFFRSPARILPRQDDAHAVGAVEWNVTALQTAKPTVANLDAADPKKAAYAGEPASTSARATGETVTTPTDLVVASVGYQSLPLDPSPAPAVPAVEEGRLVRLPFDARRHVVPNRAGRIVDPVSGDVVPRAYVSGWLARGPTGIIASTMLDAHAVADSMLSDMHTQPPTHHAESHDDLLQLLQKTQTHRIVGIDDWNRIDAEEWARGQKLGKLREKILTVREMLALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHQ7</accession>
    <name>W3VHQ7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHQ7"/>
    <dbReference type="HOGENOM" id="CLU_006974_0_1_1"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1254" mass="134036" checksum="E6DEA5B7024312F4" modified="2014-03-19" version="1">MPPKKVSLPPNPPPHASQSIPLQYTTFFSVAPLNAKNVASSYLKTEAQTWIARAQSASQSQPHSRKRRIDALRDAADAAPDASMNLDDDDDLDANDGEKEAAENTPAHRTIVIHPGSESLRLGRATDLFPIVIPNVIARRAKKSSSSTHQTAGSSNANGTPAEASEGEDADVDMTDASESPNKLDQDAGDAATSLRKNPRRSAANAPAQQEPSSDASQDDADAEVTPKRSLADGIEAIRNDLRAIMRQEKLRSVGNAKNLAANYNDSSQPEDVPEHNDLFGLQWTDEDAGGDNEVLVGEQALRLACFSQPKTAEPKQNQRRQQQQQSQAASIKPLSPPDAHRPWTLFRPFQRGTLDLNTYEQHYGASAAARALLGDVRCILEKAITSPPEDTDERQETGKVAPIGLGIPRTEFAGCSVILIVPDLFCKSDIKALTELLLVDMGFAQACIQQESVCATFGAGLSTGCVVDLGAEKISVSCVEEGLVLPETRVQLAYGGADLTRFLGELLVRAKFPYRELDVRASIADTLLLDELKRRLVTLNPADVGLNIHDFYLRLPSRPTKKYLFRTYDELILAPMSLFDPSVYGLDAKSSLKRRQRAGYVEEEAEDGVAEDTPELSVVRGLDVPVTAAMTSCVKHLLPADPTPAPAPAVSAPDTGAVASEAGTPAPAADDKAKPKTAAALADAGSTSAMGSRASSPAAKPEGADGSMLPSADASARPSPAPQNGTTAVAAGAVADEPAQPTGPAVPTIDIHREASKTGLDTAILHSLLTCVAQSGSDDRLRKMAANMLCVGGSARIPGLGAALEARLAAMLAAHYAAVAGDAASAPKVTAIPPPREMDPQVLAWKGMSVFARLEAAASEAYVRREDWTLLGWRALKEKTLFLMTGSIGQGTDGGSGMGVVDALCAGTMMGELPASDPISILVAKHLPAHARPVRDLSGTWHASSLDTTEVSCDDIVQAASTGWWRKIAVLARSTLERRGMELDEVLEWWTVRLYALARLRLHSMLRTELAAVWEALEGQQVPFGLLVLRASEAKFRGDTRSTVEQYTVLIHVCKKKQGEAWRRRAVRLGIMLAFTLAETRDYNAAINVLDPLVERALAEEEQGVQLVVVAARIWIQAGDVEHALELVQRAEQQLPKQSAAHAHIRQAKMVIATISGDFAQDDEGERVVATLNRAVVQFYRAQLDAAIATLDAQLEAEPALVASADAVVFNTATLYELAAGDETAVVGRKRQLLATIARWAAEPGPTSSAFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHU5</accession>
    <name>W3VHU5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05569</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHU5"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="41"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="588" mass="62879" checksum="5288DF18295CC64E" modified="2014-03-19" version="1">MAPTATGASNHVSQALAEHRLSMVGATGAKGLIKNARTFAIAVFASMGGLIYGYNQGMFGQILSMHSFQEASGVKGITNPTLGGFITAILELGAFVGVLMNGYVSDAFGRRKCVLFGLAWFLLGCIIQASTTGGSYDFITAGRAIVGVGIGSLSMIVPLYNAELAPPEIRGALVALQQLAIVAGVMISFWFTYGTNYIGGTGDGQSRAAWLIPVTVQILPALILGVGIFWLPESPRWLIDVGREQESLAIIASLRRLPESDLLVQMEFLEVKAQKLFEDRVSAHDYPDLQDGSRSSNFKLGLAGYKSLFTNPANLRRTLVAILIMLFQQWTGINFILYYAPFIFKQIGLSGNTISLLASGVVGIVLFLATIPAVLYIDSWGRKPTLLAGAVIMGICHLSVAIIIARCGGDWPAHRAAGWVACAFVWIFAAGFGFSWGPCGWIIVAEVFPLGLRAKGVSIGAASNWLNNFAVAMSTPDFITAAPYGVFIFLGVICFVSVAYVKFFVPETKLKTLDELDAVFGDNSGRSQWEAGIMLQAQRDVGLLRLAGIEEPKGVHGDNVSDDVDEKGSDIHSDGEVKKEGHTVVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI15</accession>
    <name>W3VI15_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI15"/>
    <dbReference type="HOGENOM" id="CLU_005220_0_0_1"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="691"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1061" mass="118106" checksum="FD0539E20A47DA33" modified="2014-03-19" version="1">MAPSVDQASAAPAANAPSSLDDVSKVKSALLSAAHSTPRSGSHTPIDHIIANTAGYTDTVFEGKADQAAQVKKLLSSKGFIRPDLVDAEVDWFYQNLGIDDTYFALESVETVADHILALFGAKIMAYTKHSNSLEIDLEKESENGAVFIHSSQAGKSQAEGPQWERRIDANYLDKSSVEKAYRLETYRSAGSVSAQSQQQLRCYFLAKCNFVEPRPAPDSPSYADIRAVSDKIFLTKASDNTLDIYQSIMDEVLRRQGPVIEMFEVEGSRERRIVIGYRMGTTNSFFSALSDLYHFYGLFSSRKYVEQFSNNVTIISIYLNPLPASNSPPIEHSIHQVMKEASLIYVLPDNPFFQPALAENTHAVQEATYAYVGWLFAQHFCNRLGQAYQSLRNVLNENDSQQAAILNEIKLRFREETFTRQSIQEVIENHPTLIRLLYVHFANIHYPGGADDQELVPTLSYQRLVKEEVLDDNQMYDRIRKAATNSHERQVLEAFLFFNKAVLKTNFYTPTKVALSFRLDPGFLPEVEYPVKPYGIIFVVGAEFRGFHVRFRDVARGGIRIVRSRNRENYSINQRTLFDENYALASTQHLKNKEIPEGGAKGTILPTLDANPKLAFEKYVDAILDLLIKGQTPGVKEEIVDLLGKEEILFLGPDEGTADLMDFAAEHARARGAPWWKSFTTGKTAATLGGVPHDVWGMTSLSVRQYIIGIYRMLGLREQEVTKVQTGGPDGDLGSNEILLSVDKTVAIIDGSGVIYDPVGLNRQELVRLAKARKMISDFDASKLSSNGYRVLVEQNDVKLPTGEIVPDGIAFRNTAHLRFKADLFVPCGGRPEAINISNVNQLFDQDGKPHFKYIVEGANLFITRQARLELEKRGVILYPDASANKGGVTSSSLEVLCGLSLEDAEYVESMLFKDGKPTNFYLSYVRDIQTIIGRNARAEFDAIWRENIETGKPRSTISTELSTTLNKLSEELEATDLFSNEQLRSAVLGQVFPPTLIKKVGLAKLIERIPEAYARSAFAAKVAASFVYANGPNASHVDFYKHISTLLSQPAPAAATAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI44</accession>
    <name>W3VI44_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI44"/>
    <dbReference type="HOGENOM" id="CLU_070952_0_1_1"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="84"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="300" mass="33626" checksum="198D2AC3A420F76F" modified="2014-03-19" version="1">MWSIAGAFFSTGATFLRAKLGTRPLPPGATGLTDLDHHLPPPPTARLTTTSWEPPAHNVAHPRAARCAIIVSKHEQQQALRQTATLYLGNLSFYTTEEQIYEVFGRVANVGAGGGIKRIIMGLDRNQKTPCGFAFVEFYTHAEAVDCMRYVSGTKLDERVIRCDLDPGYKEGRQYGRGRSGGQVRDEYRQEYDAGRGGWGHNRLREEEERKKIEAEQQRRLEREQLYQEQAGMDSGGGGLVPAGAEHMYDELEADARGHAAPAAAQHAKRERSYDQEDQELYGKSEKNPRFRDDDNDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI88</accession>
    <name>W3VI88_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_05385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260109_0_0_1"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="234"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="508"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="771"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="704"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="804"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1175"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1264"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="806"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1175"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1190"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1241"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1264"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1281"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1328"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1338" mass="144833" checksum="F3F31A226F7C3AAB" modified="2014-03-19" version="1">MSDVETSSRKSLSGRRPSFSSIRSRLRKPSLKMGKSKSRAGDDTALDSEEEDASADRSKRFSMASDKSVPPLPPLPPQVTQQSPSRPSFTEQSRSALDPSASDNHLADKRSSVLSTSSAGQAAPAPEGDVSALARSALGMTLGAHTSEASRPAGANTPVAQDAFKETINMTMLFFGGTVLAALFVAKYSILAAATISICSGHILYKTLTQRADDAKWALEMQAATQRAAGLNEGEESVEWLNKALATAWPLINADYFAPLVDLLEDSLMTQVPGVVHNVRVEDMDQGSIPLRVKSFRVLPSDESAFLQGAVAQARKDAGQSGADVPSGSNDGDADDPDTGVDVGDHVNLEVTFTYRGATTKKGLFRTATNNASSQSKASGNVAAGHQTESDDELDQLKDVPTERIHMLLYLSVGLQKIAAVDIPVWIEMVGIEGKARVRLQMTPVAPFVKHAAVTFVGAPKLEISAKPLGKKMVIDAMNLPLMSSYVLHAVEDVIKGFIAPLSYTVDVAGLLGAGDGPQDVYAVGVICFVLHQADDLPAADSNGQSDPFVQASFARAGKPLFTSRIIRKRRDAVWQETGFLLVSPDEVRDHDRLRFTVFDADRFSSDDPLGKIEISLHRLIRKFRPDGVGRSTNLLETRTDQLLPMRKGASVQGTLKYSVGFFGLAHAPGAGFAPSRRKLLRGITTTAADDAGSIDLVSPAHGESQAADDKILPPIPGQAASTSESGADDLSAYMTGFDRFVHGLGLPMDNETLRKRKLRKERVQNLASMIEGAKLATVDPPTVELPSGILAFHIHSITGLEVPGTQKSLGGSSKRLSQKSRNGPAPTDESQAEGGSAGKLPSSYVQVFLNDEAIFRTRTKSLNPRPYINAGSERFVGDWTTARIDFTVRDARMRESDPILGCVGLRLADVLTESSRTTGWYTLTGGLGYGKIRITLLFRSVELSVPRPLRGWNVGIVEVASIKATGVPQSLLDKKPAHISLETVGGKVSTDDVDAAEDYESGMGEDATVSYAFPLKEPIRLPVRQRYPNSLYISLRTDSRMPGRTHHHAWAFVPLNRISDETRIQRRLRLFETSDWDRVEQDVLRATSDPELLQTEKETPKAKLLPALEEICRTGSAVISDEALRAAQLRAVGWIEIDMIFHRGIAPEHRSCTAGDNEMRFAYDTYMTLQDAGERARPRTLANERLRQSSKASKLTVNTAGSVAPGAEGGEPVRPQTHRRILSNASARGLVTEEPGSLGEDGDGGDGDEDSLYALSLTETELDQLADEDADSDSPEGRRARARALHRHERGAAQVKGFRTLTWMKTNAEDGMAKMKRQFGKQSKRMGKMEAEGISHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIF3</accession>
    <name>W3VIF3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIF3"/>
    <dbReference type="HOGENOM" id="CLU_045637_0_2_1"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="318" mass="34622" checksum="99E5582570E4F3E1" modified="2014-03-19" version="1">MSQSAIVTTQLPLTLIAKGKVRDVYDAGITEGPHAGAILFVATDRISAFDIILQNGIPNKGKLLHALSTFWFGLLTPSLIESHIIATDYHNFPAQLKQRLDAVKDQVEGRSMLVKRAKVLPIEAIVRGYITGSGWAEYKRSGTVHGIKLQDGLQESQEIPNGPLFTPSTKADQGDHDENIHPDKVAEIIGSDLASKMAASAVALYSKAAAHAKSRGIILADTKFEFGLIASHAGDQMILVDEVLTPDSSRFWAADKYAVGRGQDSFDKQYVRDWLKANGLDKAADQGVPVTLPDDVVKRTQEKYTEAYQLITGHKYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VII7</accession>
    <name>W3VII7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VII7"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000625">
        <property type="entry name" value="Related to TNA1-high affinity nicotinic acid plasma membrane permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="506" mass="56133" checksum="AA5DEF727764D300" modified="2014-03-19" version="1">MSVPAQERDRSGSLHSDEKEAIGYPIQGNTLTKETGISAHDAEANSAFEDINSGFDEAEVKRVRRKVDRRLLPILGALYSIALIDRTNLSAARIAGAGVELKLTAGTNYSVPLLMFFVPYILLEMPSNLLLRKIGAAKQLSFIAFCWGVVMIGQGFVHSWQMLTLTRALIGAFEAGFFPACVWLISTWYVRRESQVRMSAFYLISVGISGFSNIIAYGMSLIKVSDRTFRGWRWIFIIEGLLTVVLAFVAYFLILDFPDKAAEKGFLTIQERDMILTRIERDRGDSKPDALTWAKARKYALDIKCWLYGLMFMCTTMPTYAFAYFLPVILRGLGYTVKDAFLLGAAPYVVAMVGAFGTAVIADRFFIRMPILICQCLLTIAGLGMLFATKQRNVQLAGCFLGVWGANSNIPFVLNFSQNNVAGQSKKSFVSVIVIMFGGIGGIFASLAYNEKDAPLYRKGLYATLACQAFNVLCGIGFTLYFYSANKKIRAGRKVVDDRPGFTYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIP7</accession>
    <name>W3VIP7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIP7"/>
    <dbReference type="HOGENOM" id="CLU_2373671_0_0_1"/>
    <dbReference type="OrthoDB" id="10442657at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="95" mass="10084" checksum="70CE5CB4E3E8223C" modified="2014-03-19" version="1">MDPGRRQRVQLSQSTVRASPCPARRFCEQSAFEAQLAADDTFVDERFRDSACAGFGSTAQPRAANGGASSEAIPATAMALFLGMPHGSERPQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIR1</accession>
    <name>W3VIR1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIR1"/>
    <dbReference type="HOGENOM" id="CLU_069253_1_4_1"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="7"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="224" mass="25546" checksum="7F6986B87E4B464B" modified="2014-03-19" version="1">MSGVNKVLFYYDVVSPWSYVGYVMLRRYEKLWNLDITYKPVNLGYIMKFSGNKPPITVANKGVWMWAERERAIKFYGVTLNQPKAFPINTMHLQTFLDTLTASASKSVVEQAIETCFAAIWHDDKPCATREDVEAIVAKLDMDKSKLKEILDKSMDKPARAKMQEEAKVLVEQNGLFGMPSFEITRASDGEQAMWFGSDRFEHMAAWLGQSYKGPFANDSCPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ52</accession>
    <name>W3VJ52_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ52"/>
    <dbReference type="HOGENOM" id="CLU_057349_2_0_1"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF3">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [FE] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="296" mass="32395" checksum="ABCA27A09E0BEFAC" modified="2014-03-19" version="1">MVAAPLARSGRIATRAIRSLPTLSTVSTPSTSSRSLHTCPPTPESLVDGCAPFLSASTVKQISQTWQAGLLDLLNQEVRDTQFASSSIVETVIGLAQNREKLLAFNYASQALNNAFFLSSIAPQDKLRNPTPLPKLATAVSKSFGSFPEMCLAFSAAAYGMSSSGWVWLVTDQHRNLGIVPTFGAGTVIVQNRIQQGKHFAIPSINDQPTNDADRPNSTDRPARPAESLFGALGIADKVGKELYPLLNISVHEHAWLADYGIMGKEEYLTRFWNCVNWDKVEERFESYCPQSSRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ85</accession>
    <name>W3VJ85_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ85"/>
    <dbReference type="HOGENOM" id="CLU_373021_0_0_1"/>
    <dbReference type="OrthoDB" id="3452273at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07010">
        <property type="entry name" value="cupin_PMI_type_I_N_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051804">
        <property type="entry name" value="Carb_Metab_Reg_Kinase/Isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42742:SF3">
        <property type="entry name" value="FRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42742">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR MPRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="412"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="745" mass="82108" checksum="934EB19BADA4B42E" modified="2014-03-19" version="1">MAGSSHEVQPSAAKESKVKGPIVLPSHQLPERFYKGGPRISTFRGEASKSDREPEDWVASTTCCAGYDTLGLTRLPTTNTLLADEIRNDPAAWLGAEHVAKYGADTKLLIKLLDAGQRLPIHAHPHVDWARVHVKRNHGKAEAWHILAPGRVYLGLKQAVSAERMLELVDKQEIETMLAMMYEVDVEAGDTVYVPPGLLHAIGEGILLVEVQEPEDMSILLEWRDFELDGQADGHLGLGFEKAMTAVTVDGLSEEQVSELVVRSKGRASTNLLPTEALEYFRMDKIDSNATVEPSFQLAVVLQGQVEASVQGSSPTVLRAGTTTLFRHADGPRTGGEGEVQGRTGKAHGHCLGIDNILRPQVRPYTSAVATMPAREEDLLILSVQPGIKIVGILQRKNIEASTSSQRRPIALILHGLLAHKNQCYHRALADALSIDSLRFDFRGNGDSHGDWTLGSLDNDVTDLATVVRHLHHQLGYKIELIVAHSRGSMVSWMYLSRGPEVLRADMGSAGVPNLAVVSGRWFMDGVLETYARFQEGFKTDGFYRWKFTSAGKKREHIVYPKDLEDMAAIKEPRDYVARVSPDTQVLILHGTADQIVPERDAHTYLAALDSNPARTPGSHQLHLIQGADHMYRGATQPVVERICSCATMPRNTSAACLLFVRICQLRVDGKNVGDLVDRIQTLSLEYQQASGSAVDDDALMAILINQAMPIPEYHLVVKELTESGRLTDYYTLASALQNRWKQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ98</accession>
    <name>W3VJ98_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002703_0_0_1"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF7">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="425"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="851"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1040"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="257"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="865"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1130"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1184"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1259"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1293" mass="136717" checksum="49E26BC0369891C7" modified="2014-03-19" version="1">MKKFFSRFSAAGPVTPAKPSQEPSFDRSEKHDLFSPAVKAAPAIASPFNSTGRTRALVAKFEGVAAPPQSETASTSTAPQLAIPVPTPDLPIAGHAHPPLQPSSSSGLGTASVPKRIPGSSLPASEDLASRTQTFQSETAFDPPGSASVAARTDFTEVSSNGQNAHAIKTVAFAPSPQKQRSTSPAHIGTSHRTAASQPLSRTNSNDTNVFATPGNFARPTAASQARARTWTRSASSDTSHPPAPTVSTNLRDRGTSVQTRSSKSRISSSMRSTSRRSYSYSSTPVSRDGGALLASSALSSTGSQGQSQNTDASSRPVARGSSFDLAPGISASPIASIDSHSPATGPLQFPTRTSLSMRKSYSGSNSSRPTSRRNSVDPHSPTAPGEPVIFPPSASPALRPFGFPTWSEMTNEELVRNLGPRERTRQEVLWEIVASEERYVMELEKVKDLYIDALINPEHFDLERVLPPVRPPSVASPVDVDESQCRSNAALWEDPSAAIPTPAVTSSAELPIAARFMSNVSASNAGGSLTDASSKSVLAQWDAHKAAGAQSPYSMGVSNINAAGQLATHTGQTRKRSEAAYGLGLGLGTTATRDRSAPAYMNISTAIKGKDKISRAQKLRGLSSKAGGDANPLRLTVPLPPSLREVLVAMSEGLTEAHGLLSDALKARYEEQWPLVRSLADVFMKHSHILEHYASYVCHLQRAMEELEEAALMERAFRGKRLKKERLSNTVGLGRTVAALEACAAEQGYAGLSIFASMPFQRLLKYPLLFQNLLFHTDPSTHEFESTVGMVVEVERLVRSIEDEKVTAEERDKSRDVFARIDGITDRVVLRPRPDRVLIEECALYDESARRTLSESAPKDGRSDANASDSEGAESGSEGSGLRSGRWGNASQSGLRAALRNKRSYRRLSDFLSAEQGGGGSSKAPTMGSKKDLWLVRFSDVEIKCQRIGVTALPMVSTAALRTADDDAAANELNDFAARSKDSRERLKALRSTTLRAKTRNLYRFISVVAWRNAATRQMSASKDGGLDGLPTSHEVDEEFDEAGEDDDGASISSDGESSATSSASSDSSEGVGGQAGSEKYVRSTKLSFTYWGDRIEPGRALAAPHTGSKKGTASAHGRGLGSDRLGGRSDVQVAASLHRASHSTSAASADSSVGASSRSTHEVGAARADGRTDGQRVARQARWSSVNGGSMATASAARPGGSRTGVSGRLSEPLAATSMSTAPEPMQTAVAQMHARQRNDKFGARLRSSLPYGGTGSSAAVGASTESASSHISVNSASEARNRPTSATGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJA8</accession>
    <name>W3VJA8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJA8"/>
    <dbReference type="HOGENOM" id="CLU_633398_0_0_1"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="86"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="384" mass="40354" checksum="3905BCC8A0E7D64D" modified="2014-03-19" version="1">MAVNPDALAAVRRLLSARYPTLEVDPGWLDRCIADVCQGDAAVRCGSNDQLARSVRQRLLETDLAQVVVPSYSRIAPEKLQAANGKVGDGGRGAVLVQIESMIDIGCSAASQLEIAEARVEARRSNKDPNEAYAGLKPAASASSSSSGADAMAAFDAQEEGKSQCNTIYPRRMLKLELSDGGSSANVWAIELERIGGLDMNTTKMGSKLLLKGAQVNKGYLLLTPATVSVEGGGVSAKQAVAEEKLIAKLRAQLGPPRRKRGMPSKPQASSNHAHDGNGSNHTTTAAQDRFSPDEDESMLLAALEAEAEAEAGVDEAAAAQLAERDASLPHETKPESGGPANGGAQRGGRQPAPIVMVDSDDDDDAYTSARWQETILIESSPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJD6</accession>
    <name>W3VJD6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_04844</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJD6"/>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_1"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="7"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS60922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="379" mass="40221" checksum="DF426549A626EB15" modified="2014-03-19" version="1">MSKQTYNVVVLPGDGIGPEVVEQATRVLELISSKSDSFSINLKPFDFGGAAIDSTGKPLPDDTLEACKTADAILMGSVGGPKWGVGKVRPEQGLLALRKELDLYANIRPCLFPSESLLSHSPLKPEVAKGVSFIVVRELVKGLYFGDRQEANLDDPSSDGAAYDTMVYNKFDVERITKLASYLALQSSPPAPLHSIDKANVLATSRLWRKVVQDTVDTQFASQGITVDHQLVDSASMVMVSNPRKLNGIVLTENMFGDILSDESSVIPGALGLLPSASLSGLPDGKSRCNGLYEPIHGSAPDIAGRGIANPVGTILSAAMLLRYSLHQPELADKVEAAVRKVLDAKDIGGHELRTADLGGKHGSKDVGDAVIAALEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJE8</accession>
    <name>W3VJE8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13 14">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 13 14">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_04167</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 13 14"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJE8"/>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="16">
        <location>
            <begin position="12"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="15">
        <location>
            <begin position="200"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS61669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="427" mass="46180" checksum="37B62E9F0625A10F" modified="2014-03-19" version="1">MSSTIYQATCSAPVNIAVIKYWGKRDTSLILPTNDSLSVTLDQDHLRSVTTARADASFDGQDRLWLNGEEEVIKPDGRLRRCIDEMKKLRQAKEAKDASLPKLSEWAVRVCSENNFPTAAGLASSASGFAALIASLAALYELQPEVSTSELSRIARQGSGSACRSLFGGYVAWQGGEQASGQDSLAVEVAPQSHWPDLQALICVVSDAKKGTPSTAGMQRTVQTSPLLQHRIKDVVPQRMKDISAAIQNKDFDTFANITMADSNNFHACCLDTAPPIFYMNDVSRAIVQLTEELNRASEAEGKGKLAAYTYDAGPNAVLYAPKANMPTILQTIRHYFPNADFDDTFDLLGKGANASHRGAQDAVALPQSLPAAFNSNVIPVHEAGAVRRLIHTQVGDGPRVLERGLGAESLLTEQGEPLRLQRAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJJ2</accession>
    <name>W3VJJ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJJ2"/>
    <dbReference type="HOGENOM" id="CLU_166990_2_0_1"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8709" checksum="F21F9D771C816CA4" modified="2014-03-19" version="1">MASLFSPFRNTFRYLQYAAHEHPVVFYSIVIGSVGPVAVVAVPPIRKAYGWKPAEKVPTSYPLPARQRQEINAYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK33</accession>
    <name>W3VK33_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK33"/>
    <dbReference type="HOGENOM" id="CLU_030130_6_1_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000016">
        <property type="entry name" value="Nitrilase blr3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="406" mass="43893" checksum="5CE377A055D1B9E2" modified="2014-03-19" version="1">MPSHPAAEKFGGQRGQRSLGYLRVCTSAGATYTIPQHLERANTPAHIFSSHHQHSRIVIARVSCSQTMVSATMSTSDEVILCCVQDTPVSFDLQASLDKLSKLAREATTKARALASSPSVPIVVLFPEAFLSAYPRGLDFGAKIGSRTPEGRTWFGRYHASSVPVCDTEGPEMRAIRNVAKENGITLVVGVIERCDRPETGKKRAEYGSRVVGGTGSIYCTALTISETGEVLASHRKLMPTGTERLVWGQGDGQGIRVVPTPAGNVGAVICWENYMPLLRTAMYERGVEIYCAPTADSRPTWTSSMQHIAMEGRCYVVSCNQFNTRSDFPQDYPALHDLKPDGIVTRGGSVIVGPLGDILAGPLVDEAGILVAKVSKSALVESKMDFDVAGHYARNDVLRLHVNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK53</accession>
    <name>W3VK53_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rgp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK53"/>
    <dbReference type="HOGENOM" id="CLU_005984_0_0_1"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="88362" checksum="017DFD0227C2552E" modified="2014-03-19" version="1">MSHSHYPPPSSLKVSIRPLQSSFFAGEDFTCQITFINTNPRVAHTQPLVQGEFAPAASSQLLNDTATRRVVSALPTHAKSRSVDVRALGRQHESDSASDSPQDPSRRSNLPRHLDIDDLPHRRNLIGKAAAPSHPSSNAIHPWSVSPRVASTKSSSHRSTKSVAALPQKNGTDLGLGRPTAPPAPAPATHSNPSSPNPPSRLSSLPGLGKRTTSAPIAPNHSHSRKKSVAQLQAEDLTEAFELDSLDPARSTSGISSPTSHPPSPWRANSNGDANQAASFYGLGRNDTMESVFRESITDWSQSRRPSIPRSPSHSPIYPPPEALPPGTEKILWSFAQLAGTIEIDESLIKPGDFENLKHRLAYGDLTGASASPLSVPGTPRTLGGGHLAQAADSSPPSSGWSNLLRSSFSSRPHQHRRTGSTLQDAQERTLQSRSVPTFSTPPSIVAVDLLLPPGESKTFEFKLRLPVDLPPSYLGKAIRLKYTLTLGTNRFDTAATATRGRPHTSRLIQVPIRVYNHVGASGFRPFFDLMNPVILTKEEASVTAVDTDASATPSAPSLPKRSTKAPQIQRQELESYVKQLLTKSESASTVKLDSAISAPTSQGSGCKAAVEALARSSGKVSYDISKDGKVAAVLTLVRSRYRLGETITGVININNHTSLARIARISATLETFEEVQPSIATLPAGRLQRATRIVHAEHHESVLDKGRASFSLSVPSGATPEFVTSGVKLNWLVKLAFLTISATSGEEKAKPPPHLMPGSADGFSRYHISLRGVDSLAGSVGEQSKVGLKQMGCAAETKLETVECAVPVSILPNSTSFKVGDAEFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKJ6</accession>
    <name>W3VKJ6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKJ6"/>
    <dbReference type="HOGENOM" id="CLU_073408_0_0_1"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="316" mass="33845" checksum="E9A0610DA5885506" modified="2014-03-19" version="1">MAFASRSVSLSALRQLGSGPAVASSSRNVAAAAFSTSSSSLAASSQEDATARKPPFTAAAEASQGSTERNAIGRGRKSAGRGRPKMLAPFDEWIQSDARAYKQPKPGMGPNWIGDTPFPLNPSFNPPAPVRQSTKSEIWRLHTSDPATYTIRALSDKFSVGLQRMEAILRLKALEVEWASQDKPLQSEFQSNMDRLLGAQDRKRAPEPEPSQQSTDKSVRGSQHEEFSEAAPLDAPSVVAPALADERLKRSSMIAALPSGGPDHDAHSTSKVVRTGRAPIAITNVSGDSYMGAGRVHRNVRRAEKRKGSKATSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKP8</accession>
    <name>W3VKP8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000017">
        <property type="protein sequence ID" value="ETS61321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKP8"/>
    <dbReference type="HOGENOM" id="CLU_071330_3_1_1"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="266" mass="27986" checksum="BFD57DFA23B78C3D" modified="2014-03-19" version="1">MSHSIGTKGTAVILGASGAVGKSLLPLLVSETSPYSRVYSFARRAHPSPPAPAPGVHFEEIMIDFAALYEGNRAEQDKFDSLSHSFDSIYIAMGTTRAAAGSTQAFEKIDRGYVLTAAKALSKQGSGATLVYCSSRSSSSSSWVPYLKSKGLTEEGLAGLYSNTVIMRPGFLKNAGRPESRIFELFLEPLLGAVSALTDSWQASVSDVAKAMVAAAQKGPETLKAQRTGEVPGNSFRLQSGASRKGLAIVQNPGVLALARDQPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKV2</accession>
    <name>W3VKV2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260929_0_0_1"/>
    <dbReference type="OrthoDB" id="2553867at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="839"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1308" mass="138635" checksum="CBB8A3E895AC50A3" modified="2014-03-19" version="1">MAGSTSAIRCPCPAPCCALLHILFLPLPSVQIHRAASVSTSLTSFILVACLFTTILTLPPFPTNLHLLLQPQLHHLCPVSDNPAVRHPSIPTIFNIASANPTVFSLLHCPILSRCLNLLSSLQAIARPSQSHSGSIYHRLFARPSPSKLPSSPTAPISLRSAAMLVYMSQYVEERSASPAPIPTRPPVARPPPSKSKKGKINFVSKASLAIFDPRHAMGIDTGRDWYEADYHTPEPRSSFDHASHRAGRYSEDRERSHKWTASPTPELEAFATSMEDYAQGPSDVAASLEMTRQPSASSSVFEDDRDAPEMPARRRFYSRKSVAASASNTPTSATFPSDDLLFSPLGTKPKSSRSAGAGANAGSSSSSLARFFTRKKKEKTPHLSSLASRSTPDLFDGVPQSAPPTTLTFEQSGFHFSPQRKGSSGSSLHESPSSLPTSPERAPLRMIQDFSPSRTSPLSTKKSMSALRQIREAQSGAGAANGRSITFAAPEERPRPRHSNARSDMFDAAPALPPLPSFDSSSPMIPLEFAWDAKRRTGRESQMPMLGANRPVSRVVSSTGRGVPSPGLNPIRLNDLRKSTITLRNEPVLQSGEEGRSPTGKSAALGKRSVNSSSAKRLSMTQRVVDGLLDQNRGREEPEMRARRSDMEVRSARRRSRSADGRTVPALKLHDYASPPSSNSHSDSVFPAFVRHAPVAADRANSPQPRFFADQHAAATTPTPHQPAAFAPASPVSPASPARRTAAHSQSPSRSPQRPPAAVETHQARRVNFAGQRAKAVAVASPLLLSRSPLMAGRSGTPLPVVNIMPPTPDLAATSEDHERQEEALQRYETVVAQQKPVEATPVPTPTVKAPAASEQRALPSRSDAATPTPKSVPVATAPVQPAKVARTAPASPESVYSPASVYSPEENQSPFAPLLAGLLGNDETVSKEQVAITADSVAAELSYAGVPRTESVTSQLSEADSHRSSSSGAFAFSRSMSSSSFASGGTFSSASSNASESPERRMNYLPSSTTFEFSPTKMTSSTSVASTAGTSIFELEAELRGSVASKGTGIDVLESSDVFGSSELKKAFQLKGASAPANAPDSSDCDTPTLASVRQMGASVTPATAARSEDKTVGRQLGLSMDLSELAQELGLGRLSQIGLAHLKGVESLAEKPAATAAAACKKMQPVKPPKSSARGAAGTLSRFGMGMNDIASSAAMSPLPVSIAGRSPQTPPRTRIPLTEPQSGPKVSASGVPKAEGGFGLGLHFVESPSPQSQPRKAAIAPGSYGKTLLDRTQAAPAQIDIQLEMQAHHEVYEQEEPEWVGVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL01</accession>
    <name>W3VL01_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL01"/>
    <dbReference type="HOGENOM" id="CLU_1533217_0_0_1"/>
    <dbReference type="OrthoDB" id="10426465at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834637" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="175" mass="18850" checksum="4F9D9C1B9B9430EC" modified="2014-03-19" version="1">MQLIKSIALVAVLAVCFVHATILSDSVSLLEAHVKDAETLASQKAAFVRMVDRYYRPSAKAFWTQHAVPRAGKDKADRASGLQAHRLTLESSAFERALLIEKLPALRLRESTGTSTSGSLDSDPASSWAHSSDPRSLLHCSRSTAALVICTALNFVISEGKAGAYETMAYPDGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLB1</accession>
    <name>W3VLB1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLB1"/>
    <dbReference type="HOGENOM" id="CLU_785257_0_0_1"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="97"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="379" mass="40458" checksum="772020FD024CE1D6" modified="2014-03-19" version="1">MTVPTSNAHGKWACEITRGDWNDMDVPMRDARRGSGRKGASRASRRSDPYARDSRPQPSAPTQRDTYEAAPAATNTPQAGMSYPPPELSIRGSSGPTWIIVSNLVAGTSTEDVRLTFSSFGRVEEVKQRPAPSANHPTVSFEVAFDKRQDAETAVEKFHGALADGRILQVSIKKPEVARDAVAQFNRATAQAVAQRPRERAPNHIAAPAPLPYTPAPAAAVAAAIPTAPASMRSRAKAAELLEPRAKKSNQAPAAAGTKAATPAKKPEVKARPLAERIPEPLANRLLTPAQAQKLRAQEAKKKARDEAKARAIAATGKNTVLGKRLGGLPLAQRLVQQAGTPKSDQTAIRAAADKKKRKKEAARARKTAKTQSTGMDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLJ8</accession>
    <name>W3VLJ8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLJ8"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="301" mass="32758" checksum="59E4EC23241E0CCD" modified="2014-03-19" version="1">MTTASESHRPWALITGASEGLGKEFALQLAQRKTHNVILAARSVDKLESVAKTVSEQVQCKVVPIDLSVAGAAEELDQKTRELDVALLINNAGVAFGGPFEDMEYKDVQSLVAINIVALTELFHIFLQRIKLQHKKLSEQQKQSNYALAGIINVSSVSGFMPIPSMALYAASKAFVLSLTESVYAEQRNEASDLRIVVSCPGATKTEIWTKGGANEKSLLLPLGTKEHVCATTLAALDARDKPVIVPGYFNNLSVASLRLAPRSLVRFLSRRLMGQDPSLRDPQEVQDTFAKLGRSVPTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLM1</accession>
    <name>W3VLM1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sorting nexin/Vps5-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLM1"/>
    <dbReference type="HOGENOM" id="CLU_015466_0_0_1"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="2">
        <location>
            <begin position="246"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="639" mass="68676" checksum="522C966C31E5A5A3" modified="2014-03-19" version="1">MSMPESSTRTAPQQHPGIDKPLPGVAPSAVMRPDLDQRKDELNGRAQDTAPRIYEPHTKPRELFLRVRVQSIERAKKDLVVRIDALTNLPHFRASSYPGVTRSYRELCLYALALSLSSPAIIVPALPLPSTTASGVEDTRILRLMLARWFSRILAEPSLRDHPETRNLVEADFAYAPTPPGTGSSSAARKRFANAMASAASVAYGGVDATGGLPNGVLATSASAGSRISSSGFSILGLGTSSKGLSTSRSVYDDDEDLVAARAEVTRLEMQFADAAEASEKLANARRSLNVALSDLSVKLSNLGAVEEIRPPSLRLGLPYVLKRTAYTARSLGELQDALSNTELLTLGDAVAYQSINARAAKETMLARNALVEEHHTAQKATVNKKREAEHLKMQRNLRADRVDDALEELHEAQRHEHALAQHLKRISHELHASLQSHSRHAHHDVQQALIEHARGSTMFAKQMLKEMHALSAELDASRRGEASKAHTPVRPTHTPRQSSVSRPPYASVDSGWSTPTESPAQPRSEVVEPSRPSLGSPRGSGRSESMAPSLSAESNAWSRAPSLDAPSMAQSMHAAAIPPSSPSPSQRAPPVAQSMFLDRPTPARPNPFGTLNSGSSGTASGRSRISAADAARSLAGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMB2</accession>
    <name>W3VMB2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMB2"/>
    <dbReference type="HOGENOM" id="CLU_1906478_0_0_1"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="51"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="154" mass="16034" checksum="A90FA5DC0BD3DB21" modified="2014-03-19" version="1">MNAGDRVQKSQIFSLIPPSSPLHFGTTPLSVKLTGVMSSRAEAAAAEAAALIEASFVGRTSIVHIPDGRAFCGTFLCVDSGSNIILSDTDELRLTSSGGTSSRNVGMVMIPGNCVVKIEVQRELPQHAAPTSEPAPLSGSMAQAGWPDDDSMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VME8</accession>
    <name>W3VME8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VME8"/>
    <dbReference type="HOGENOM" id="CLU_040446_1_0_1"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="6">
        <location>
            <begin position="276"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="414" mass="45882" checksum="4553D428CDF73EDD" modified="2014-03-19" version="1">MAVIEPLDSGSASSTRTPLPRPPPRSGDFTYAQPSDQPRDVDSTLKSWDSVPLFMKDLPTDADADTQTALDALQSLAFDGSPDEVAANFKQQANDYFRARRFREALGFYSQAIDAHPHDQALLETLHANRAACHLELHNYGSTLRDTSAVLAINAKNEKAYYRAAKALIALDRCKDAVDCCDHALGANPDNDAIAALKLKAETRLAAVEKSQAEAKERTRRADLMAKAIQQALVVRGLWLETTPRPPDNPTPAHFDPSSAPSIPLTGPESSKWTVPDVIRTPLVVPVFFMYPQHAQSDFISDFHEDTPLAEYLSTIFPSSSRGSLPWDKAGEYYDGNLVVYASTRRQRLLKLGRKLTLRHVMDQAYKDAEPGMDKVRDRDGLVMHDGILSLVVVPKGDAEKQWVDKFKAQRDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMH6</accession>
    <name>W3VMH6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMH6"/>
    <dbReference type="HOGENOM" id="CLU_037983_0_0_1"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="52344" checksum="9E8AED3BDA22F54D" modified="2014-03-19" version="1">MPDETAQQRTERQNRLSHAMGVMFLQDKVDKLERDVSKITYPRSMRHTHSAPTAELNPTQPRYHAANPPPKPRAITGPGLNPTPTTTTATASTSTSATATAATCMRLVDASVLIFSLRSVHNWTRDRATCVIIPLEAINTLDLLKKGDEPINLAARKATRWLEEKIAIAPHDGDQLLTHPAPGIYAQKEAFRASTAQIDKIRAHVVATRLGAADQAEGSAAKDAFGLEGAPRYLRELLAACVYCRTACASEVDFKVALAYPPAHVQDSMMAAHAAAGDRPSYLVRTDGRATEAWLDAYGVPFEVVPTSKTWTGEKQSSRFRTHAASSHDTDLRSEPSKNARPDAGHSSATARGRATSSSPSELDSGHFGGIDAEEGPIIARPSSPASSAASFRTSFTASTSSTHDDRSQRSAHSASSMRIVRHPPDSSAAKDDVETGSKWCRLTSRTLHKMRSGADKMEDYLRRLEAGASAPADRPRTTQHDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMI9</accession>
    <name>W3VMI9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMI9"/>
    <dbReference type="HOGENOM" id="CLU_554548_0_0_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="481" mass="51307" checksum="6BC4C76DC972F554" modified="2014-03-19" version="1">MSYISSGSSSSGATFSTGPSSSTSRSPSAEPSSSKQRRLTLQDIHIPAGFEIAKGLEEPGSEYPSEENIQRAAEVLQSLRGRMPDGSDGQVAACDYCRRRKIRCDRIKPTCGSCTASGRKCTTEDMLRKRGPPSKKERAILEAAGIIFRGTRPHRRRRTATTSLGSGAASKQQEEMLRKVKEVAGTRTRANSTNSGENAAAAAIVADAFDQLNGGSKSSWMEMLSIATQSANPFADSPASSPSDISAHDTFHIDAGACDYGLATSTGLGAAPLLARNMDSLPGAPNNSAQWDNMWAAFGADLRNKHSATNQAISELPNLSAFACNATVDSKDGLFRSPLASFDAGALDWSASNISPSQYQMLFPNGAVPPMQHASLPMVHVDPQIMAPQMHQVAEQPFMSSQSSMAAEAIAFQSAMGHFFPKSNPLSSSLSQSSSTATAEANTPTEIEQFISMAEPNHMHQHQEQLQPHQLQFSIDTLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMJ3</accession>
    <name>W3VMJ3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_03578</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1283"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1323"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="470"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="705"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1095"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1422"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="971"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="983"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1719" mass="185917" checksum="4FB8976414D0AF96" modified="2014-03-19" version="1">MIPSISFLSGWGHGLAARPALHMPALDDFYSLAAAAVCLAVLGILGLVLLTTLSPSQHGYTRLATDAESPSPPTLDDENDDNEVQGYAFELRKARGIPIDTQEFERHRLLVHISIAVLAVVGLALDAAAIVQLVLLSDEIPSSLYLASASAGLHTVQVLLSMLDLGLAEATRLTYISLLAFVWLLVKLLVALSEYRLRLPIHAADAGQLLFTLNVLCGTIGLVVAFISPTGPKVMVDATQNLTARQILRNTVGGGSVAQNAWGFKAFPVVKQAHTKGRIEEDDVPALDYTYKSAYVAEEIIRKYRQLLAVSTAKNPAAGRSDAVKARVLLSSLIVCNAAELKATAVVLVITTFSFYFPKLGMSILLNGIEQYDQTLKGPNAIKDTVPNRARATLIYSAVFYLTLLWEGFIVYYYFRPLGTYLKTKVQTQLTTLLAWKRLRQKEASAPSGADDAEDAKEGEKEEGEASASSSSQVINLVTTDANRIFSHIDMFSFGIMGPLEVFVGGWSAYYLLGNGALMGLLVAALMQPIAILIGRITERIDDKLQKSRDKRVMLLSEAIRAIRMIKYEAWEDDMAARIMHTRRAELKCQAQSWIVFTFFGGFFAFVPMLTIVVAFAWYTVVEGQQLTASVAFPAVAVLMELRFAVSYLPSNFLMIIQGWVSLKRIAAYLETGEVELKTGEYTPATRNGADHNDSTSSSIGRIALKNAEITWPSEGDASAASGAATPGRFSLSIPEATFEVGKTNLVCGKIGSGKTLLLLSLLGEAQLTSGSIECPRSHPAASLFAMRSATSHRRGKWWIDLSLAAYAPQRPFLFNATVRDNIIFGLEYDAHRYRAVIFACGLKPDLKIFKDGDRTEIGEGGTNLSGGQKARISLARAVYSHAGTVLIDDCLSALDSHTTKHICEKLFDGGESGLLAGRTTVLVTHHVKLMASRCSKVLVLQEGRQAFFGSADQFINSIFFQLESEQSAADKDDEEHVPSFGSSTSTAANSAANSDEEDESLLHPAQAGGAKGPNASEFSVHTVGADAGRTTLRRRTSVSAFSHVSGLLDGAAEGEEAEGDVHKQVTEETRKQGRVLFAVYSGYIRAGGGLLVWLLLLGSFAANAFSDLGANWWLRLWAQSTADGDAGIERAEHSTEWWLSRWMLIQSVQVVVLTAGYALVCTASLLAGSRLFKQLLRTVLRAPLRFHDSTPSGRLLNRFGRDMEQIDSSIAEELTDAAKSLLMALAALVATWIGGGPILIVMLFFMAPVFYVLVSTFTIAARDLKRLDSNSASKRITCFTDLITGVVTIRAFGSSAAYYATLMERLDENMMFYFWQGYVRQWQSLLFSLATSGFVISTVLVVTLVPGSSAARAGFTLSFVQNLTSMLQFGLRSMSNVEQGLVAVERVMEYFDIDTEPLDAPPQTGGDEIKVAPSWPDKGAIEIQDLHLAYADNLPDVLDGISLSISAGERVGIVGATGSGKSTLVSALFRFFEYRSGSIVIDGVDIGRLGLKTLRSRMKIVPQDPLILSGTLRSAVDPLEQYSDVDISRILVRVGLLKEKAPPAGGYGTFNGAGSVPNIAGGSTSSSTLLAAQEESSDDSGMLTSLEARIEESGTNLSAGQKQLLSLSRILLSASNPENANSIVVLDESTSSIDYATDAKIQTLLNEHFAAHNTTVLAIAHRLRSIINFDTVVVLDHGKVVEKGSPRELLMRDDGWFCRLATSTGEDELGALRKAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMT5</accession>
    <name>W3VMT5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMT5"/>
    <dbReference type="HOGENOM" id="CLU_654163_0_0_1"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="80"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="476" mass="51737" checksum="300674ADEF71BFC6" modified="2014-03-19" version="1">MHLGGWTLKPPKSSARTTRFRLIHLALGPALDIEAADQGQNGSAIARSTAMDKGKARQIDPDRDGVPPRDLLQDSPLTYNQLISGIIDFLEVAFHTILCLRSVYPFDVFARRKKYSHPCYQSRHPGLNEYISRVLAALRREIERSSVSKVILVVRPNVVADAQSGNNASGSTNESDANAADAYERFIFSLDYILPSSLIDPRDRDLAISSNVTSAELELIFRGFMQKLMVVDGILYDIPPAPPSKAGGGADANTSTELTFAIVLEMNNEDTSPTGKDRNEPNTGDWIPADTEHLGRGQGARQQTSEGIDAAPKVRPIKTLDSGVINLMLYVEEDILAKSGASNGEPRPAKKRSEARPTSAQVSRRSGQVEEQLLHSKATQIDVSAAGRGGMHAREIKNRARRLDAERDLDKPALAEAEAEPDIAQAKNKRKRARMVLGETRAAESDTESDSSAPDSPSGSSQSIRDDHGHNLSGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMZ1</accession>
    <name>W3VMZ1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMZ1"/>
    <dbReference type="HOGENOM" id="CLU_376825_0_0_1"/>
    <dbReference type="OrthoDB" id="2553581at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="736" mass="78002" checksum="85F1CFCF17771326" modified="2014-03-19" version="1">MTSIISAGRETEGLGIGIGLGIPMDVVKPAYGEGLGLMAESGMCWPYTARHHSSTLYRGGTAYDSSPTLSSSSASSDSTQDRQVMQTSATHDVLLSYLSPALSNASSDWDGDVAPKKVYLLSSGTKNPVWKQRRCRSETFKFPLPPSARSKVAPLKSALRPSQRPSIQQVGASPPLRVHSDAWKRKSNLSPALEQPEPVSGWSPYSSHAPTPRPVSQDLTHAFLASDARPPSYNATATLPAYSPPEVTSASSCSDSSRTLVSDTDESDAEAFGADAAKLARLHASLFLLDRNVSELPLSLADKRAADVGGSVEEKMAYLCGLGYRYRRASGRHARKASAELQASREQKADVGAWWSEDDEPAKGEVQSYAPVLGRAVRVVSSTASAVTSSCSSPILAGPLAAHTEEDEGDVTMRPRREGGALGGEFSHLVQESPVKKASKVEMDFVRDANMSPPLSTPELELELGGSPLLLDGLPSPIAPCRTPYRLELSFSPPSHTVEGIAGCRPLVSKPALLSMKTAEVSLAPPAKAASVVQTSPAAAGRVGMSTSQSCPALLDEGPVTIERATRAVVGGSVLARPRPVRGQAGSFFSRGSDTPVEPDIPIIARARPVRSATDHHSFTSQTDVRKRKPSAKLSVQATAPALPAVRVPLRKSSLDLRTSVHPNTVCDDPRAQRLYYSSATAYLSQPLADAADAARARRNRPSFPSSASMPVLTAPPPRPLKGILLNHRATVNSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN03</accession>
    <name>W3VN03_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02807</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN03"/>
    <dbReference type="HOGENOM" id="CLU_055356_0_0_1"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="313" mass="34137" checksum="E1681DE4E58BF72F" modified="2014-03-19" version="1">MSAIRIVHPNPDVKRGVQYWEGVEASVDGVLGGFGHVSRVESLGSRSFLLGLLPHLSFCAPASSNVSSFQWKRDRIAERGGKGRACTRALDCGAGVGRVTEHSLLPIFDEVHMVEPVAKFLLEAKKQSASWAPIKTPPSSSPFQARKAVHFHCATLQDIEPSKPYFSAAPVDGDTIPPTVSIDDEAAPSKDASETTAEQKGGVAGSQDEPVTYDLVWAQWCLQHLSDKDLIAFLQRSKAALKEGGIIGIKENVCTEEADGTERVWYDDEDHSITRSTKAYERVFTEAGLEIVKCEVQAGMPAELFVVKMWALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNP6</accession>
    <name>W3VNP6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNP6"/>
    <dbReference type="HOGENOM" id="CLU_020370_5_0_1"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="631" mass="68022" checksum="20CC6C276ADE5C8B" modified="2014-03-19" version="1">MSSCGASSCVSKPPPSPRFFDGSASSSWQCIAVKIMSATASSVVVEWTRDAVDDHGQAIELQPVNRIERTTSSNSAGEGRASQARSRRSEDVVAEGHDEQDEAFGSTPASGPSDLDGKGTLLLAIQHASSSWGFRSAEFAYPLMMVELFTNTLLPASIYGFVTTAGAILFSNNVGRIIDTYSHTKLRTLRAMILSQKLLVGASYALFLVLFSSASLREQAENGGRGREDAAANAAPWAIFAGITLLGIGVMLSNVGVSVAVEREWVTIISDGSSARLTRLNAIMRRIDLISKLVSPLFVSALTSAMSYRLASVVLLSVSAVTALFEVVFVGIVYRRFPTLAASEKEALANKAASAATEQPDATANNQLGSKAKGGRLGQLFRRAIKSTANDIGQQYRDWKLFVRLPIFLTSVCISLLYMSVLSFDPTFIAYLKSETLYSDAFIAGMRAVGVVTGLIGTFVMPVMEKKLGLVRTGSYSLVAELVPLVPAVVSLWITGAPQDRFGLSDKRRPSWNTGLLFSGLALSRVGLWSFDLTQLAMLQTALSPEQLGQDAGRKNALMALQFSLQNVFDLGHYALTLAWRRPSEFKYAATVSIGAVALATVIYIGGYARRVRGHIVHLDGLQRLLSRKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNR5</accession>
    <name>W3VNR5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-coumarate-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNR5"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="369"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="596"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="76949" checksum="14DA19BBF2641DD9" modified="2014-03-19" version="1">MLDSLRASTLHISDYLDRFAARVLPSVHQQGSSSLPPLLLYGAVLAASLRTLSLATADYKRKFYIEDGTMIIKSPHNFTAPSYTLPEFLFKPIGIPACKERVNVPLLFPAEPEVTGRPDAKPLSLVDVREYATNFASALISGSTESGRKYGRGDVVGISASNQHDYLACALGVMMTGASVALFNPAYKPSEIAHQVRMVKATAIITTAASYQATQEAAREAAMKGEDGLEHLSAIPEILVFEETHDASVAKILKVGKDELPESRALLDNVDIDPKTTTAVYCFSSGTTGGPKAVMLSHYAMVANVIQSSYTMLDRVNDPLIDEDNWYENGREHLNGYFTTRVAQTWNTAADSVNTLTGKLGGINLAPRLSRGEFHLALLPLFHCYGLLMGFMGLHTSTPTIVLPRFQLDVFLATVQNYRVTFCFVVPPILLALAKHPMVEKYDLSSLTKVSSGAASLPSELRDAVKKRLGIVSTDGYGMSEMSPLVCSQNSKDLVHYPGTVGQLVPGTEAKVIDLDGKEVGFDEEGELCLRGPQMMQGYLNNDEANAKTFLPSVDAPDRFLRTGDIVRVNREGYVTITDRLKDVIKYNGFQVPPSELEALMFKEERVGDCAVLGVPDKEGTELPWVFVVLNPKTKEEVGDDEDKKKQLEKELLAFVNERVNASYKKLRGLTWLDALPKSASGKILKKDIRAMVEQDKLAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNW6</accession>
    <name>W3VNW6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNW6"/>
    <dbReference type="HOGENOM" id="CLU_000960_27_4_1"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="30"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="528" mass="55872" checksum="B3DFD8B8204FA6F4" modified="2014-03-19" version="1">MSSSTSTISGSPSAPLYNAGTLGKARQLVGVAALCCAMLLTQSALGQTVVPIRSIARSFGVESSDAQQSWFAASFSLTVGTFVLPAGRIGDLVGHKPVVIAGYLWLALWALLAGLSHYTRSYIFFDVCRAMQGTACALLLPNSLAILGRVFAPGSFAKHLSFSFFAATAPNGFLVGAVFTTLIDMNRRMGWFWGFYVMAIVATLLAVLCVWVLPSEQEMQAVSTSWSKDHAAVNGEGQQVPEQAVGNKGRWWDKVDLFGTVTGVAGLVLFNFAFNQALVVGWQTVYVYVLLIVGVVLIGVFIAGESRALYPLLPTSVFHLSGSLILLSLAFGWASFGIWIFYLNLFQQLIRGYSPIFTIVSIVPAGVAGILAAFSSAYILGRTSAPLVMLLSLSAFCIGSIINGIAPVGVPALTYVSSAIMPFGMDMSFPAASIILSDFLPSHQQGTASSIVNTIVNYAIALGLGFAGVVETHVNDQGRNPLKGYRGAFYMGIGFAGAGVALALVNLLLHLRSSRSANSHADAKTDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP53</accession>
    <name>W3VP53_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP53"/>
    <dbReference type="HOGENOM" id="CLU_303058_0_0_1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="983" mass="107649" checksum="E49E92A479ECFDDF" modified="2014-03-19" version="1">MSEVSPTVTPPSGKEASLSEAHEAQMDVFVVTTASHGEVRYTRQEERKLVRKIDFVVVPILLVLYLLSFLDRSNIGNAKLDGLVKDINLRDYSTALTLFFVGYVIGEVPANLVLKKTSPPVWLPTLTLVWGIISVVQGLVHNQAGLFAVRFFLGLSESGLFPGSVFVFSMFYPRRERHYRVALLLSGAAFSGAFGGILAYGIGFMRGVGGKAGWSWILILEGLLTIVVALFAYWLVPHYPMKSRSFTDREKAIIAAKMQADRDSLDEETFSWDGVKQAFTDPYVYLYGLLFHGFAFALYTISLFMPTIIADLGYKAADAQLLTVPPYFLAFIFTMTIAHISFVVNRRLVFIIGCALLAILGYIVQITSPTVAGRYVAIFITTPGVYAGNALLLSLPSENVSGQTKRATALAMQIMFGNMGSIIGVQLYRKPLGGLRNVNYHISHGLSIVWLGFGIAAASTLWFILSRENRRRDALQAQNNGKDAEQSQEELKHLGDRRLDWSRLGHTTMSDLQRSFLKGKLSRLPPVPPFPTGADEEERAEAESGDSFGDAGPSIASASSSDLHSRRRAQRRADDFAPRTAEGYFEQALEVDVPLRKGSGSFRVYFTPPRPKAADALKPNVKPSAAASIASIDIDVQSSALPRLDRKLGLSGDEDDEDTVDATSASAARNPGTLFVFHHGAGFSALSFALTAAELKRQSGGEVGLLAYDCRGHGRTKLHNVEATPLDMSIDTLSSDLTLLLSTLYPRADEMPSLVLVGHSMGGSVVVSAAHALAASGFTRISGVAVLDVVEGTAMDALEVMRSVVLSHPSGFASVQDAIRWHVDSKTIVNAESARVSVPPLVEPNPLHSASALSTETDNTYEPQEILDEADETDKASSTHAYKWRADLLSTEPYWRGWFEGLSSRFLSVRSARLLLLAGTDRLDRELMIGQMQGKYQLEVIADVGHSLHEDAPDRTARILFDFWRRNERIQLPLKHIKKVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP84</accession>
    <name>W3VP84_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP84"/>
    <dbReference type="HOGENOM" id="CLU_080778_0_0_1"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000025">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="83"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="300" mass="32866" checksum="C68B7D4EBCF1E8FC" modified="2014-03-19" version="1">MHECLTKAVVDPHIQHEAAPSEPSLQRSSSSPVCPVRLTPLPIGCPSTVATSASIACSLPEVILSQADRPLPRFTKMTSSPSGNTLLLKRQLTELRKRPVDGFSAGLKDESNLFEWEIMIIGPNDTLYEGGFLRAELIFPPEYPLLPPKMKFITPMWHPNIYADGTVCISILHAPGKDEYGYEDASERWLPVHTVESILISVISLLSADVPNTDSPANIDAAKQVREDLTGYKKKAGKAVGRGSIRLEPQSVAHGLALPRFKCLDSSRIDQVQRTTGRPSAFIVRPMYHQHLPTSNLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP91</accession>
    <name>W3VP91_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP91"/>
    <dbReference type="HOGENOM" id="CLU_029472_0_0_1"/>
    <dbReference type="OrthoDB" id="2538408at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="346" mass="36918" checksum="F31CE104978D6257" modified="2014-03-19" version="1">MSAVYSIYTSPNHAPIPNHLPTLIVTPYGQPHHTLYSYIHTNFNKETYLLTPSPQGDLCVAKMVPPPGSRGPGGGSSDGGHSNGHSDKTVRCEASRNLKWSITNTGIHAPVYKLTLPNPDAPGHEQPLFQISKPNPNATWWTMFYFTYAGHLIPPKRIEFGKIQKNAAAGSGGGGGTRVTIAGKTPEEKAVWQTLGEGNEDMVEWIVLCAALNVLDDEIIKAAQSTEPKRAPAPSASTAVPSSRPAVGGAMRGPNPPQQKMPMPVPQPQGGVNAGYRGPSQAAGMRPAQGAGPQPNPQMYQQQRGPPPPQQYRAQGPPQPHPQQGYAPPPQQHAPRGPVPASGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP96</accession>
    <name>W3VP96_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP96"/>
    <dbReference type="HOGENOM" id="CLU_427107_0_0_1"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="277"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="590" mass="63688" checksum="95E4896FA32D6591" modified="2014-03-19" version="1">MRRSVSSRSTTASSSTSSSDTYGDHRQQSRATGQSSYDAGLGGKSYYDRYPERKRTGPYVPRATLVAHHESHASKPSVAKADPSRRSVSSTYAASSIALGRARPHAAVQEPVKSIDEIVRAHSSSLLSVPPLQRAPQRSASWSAFELDARTSPEAARRARRFEADSDSDSTRSEDSIEQEARTILRRTQVDEIESGLSQLRIPGKHTSAGPSTERQASLAGDSTKYRQPRRPLTRDSKSDAAGPNCKGLSHVAMLNMAGSRQLQVSFADVGLPSGHPVMVFLGLGASRHLIGLYDDLATLFGLRLVCIDRWGIGRTDHVAPESRSILGWSFVVEQVADRLGLGKYAVVAHSAGGPFAAALALLFPERVQGPVHLLAPWTGMQQDSGYRWLRYIPDGVIKTAQAAEWRIQNWKLGKEGTRTASKTLPAQGGDDAAPRSPRLGVGEARPGSQASSGADTATWMEASASALYASDGRGGNWEEAERNSAVELLRASHAESSRGLVDDLNLVLGKRPWGFDYTDLGVACEVWHGSKDEKIALSSSVSLAREMRDCQLHVVEGASHSLMTNSSVVMQVFESIVKHWKAVSPSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPL6</accession>
    <name>W3VPL6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01788</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPL6"/>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="129"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="231"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="322" mass="34416" checksum="3B053AA29120AC5E" modified="2014-03-19" version="1">MSRVTPSSALSRDQAVASAEHPQHNPPLHVAHSPTYTLAATFASAGLGNAISAACTNPADIVKVRQQLDTSRSGFLAVARGMVRREGVLALWNGVTASCLRELSYSTVRFGLYETFKDGYSSALGVSDSSFALKALSGVSSGAIGSAFACPTDLVKVRMQAIRPTGRPPYSNTFVAFAHVYREGTGIVGGIKSLYRGVGPTIVRAAVLTSSQIASYDQVKTTLKRNQLLDEGFALHLSASMVAGLACSVTSAPFDTVKVRLMQDKKREFKNAFDCLAKLVANEGPLALYKGFAMCWARLGSHTVISLILFERFRTLFGVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ40</accession>
    <name>W3VQ40_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ40"/>
    <dbReference type="HOGENOM" id="CLU_345882_0_0_1"/>
    <dbReference type="OrthoDB" id="2551866at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="741" mass="82658" checksum="5A7B7AAAF4846159" modified="2014-03-19" version="1">MVAIQGPAERLPSPIARLGREEKKCPAKYGTKPISSARGWRGLRAMRHAAQVCRGLAEAARSLERPYVPRHVPLPSSSYSAAAQSPALPSPPRPNALDRKGEVESQRPKTIAQRPGAGRLRDSVSTDSSSSTHNSLAKTRQPPIAQPFSVRKFEAPLEVDSIRSSTRQRPKSVRDSGAVDAKQKRREDGRTSTRAEGGSILPAYVQAKLKRLKTVYPSLNQEQALLLWRTFERTRTFRTYRPQALISWYEDHVWTTERQTTDAARIESAASLCMLLRYAYLRNDLRSLLRVEARAVRSAWLAKDRHRTTSAPGSTKQLGGDEADGVTLWPAHGEDPRRLAHNLKVALAARHGDWIKVEQLLDAHGAARNRGSHELDAVGWGSLLRFGLGSVETVTEPIVTPRPVEEPAPSKSSARKKQPRKSAMPEVVEAKERVEEPKEDGDEKKLQAEARISLTKRLMPQLLRQMTAKQDAAGLAPGWLLDAVLTQLLEHAKSDAVLRIVRLALAETEPQQDPLVRGGFTGMLNLALAACVQDRKVTLAETLRIFNSITGASFGRDLAGRSTQAEGKAEIVPNEESLVLILKKVRHPLFRASWSRKLLDEFVQRWPHVRLTGRSYRMVLDLCATAPPKPTSDSHAREGGERKVAVPGSIPDRARGVIVKATLLERTLLDILARFETNPSTFHRTTTNRFRFNHTLVNLRRIVKLKLATHPQPTQLNHIIHLIHRLQYITRKPSTPKPYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ52</accession>
    <name>W3VQ52_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ52"/>
    <dbReference type="HOGENOM" id="CLU_015320_2_2_1"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="595"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="659" mass="69561" checksum="0A8A4ADB5E2A5957" modified="2014-03-19" version="1">MGNPIPVHLEQECRKATKILNDFVDPVNGLDKIIPLSVLQRAKGFAIFSVFRIGFLLSARAGSGVVIARTEDGCWSAPAAIGIGGLGGGFNVGAEVTDFLIVLNSRSAVRSFMATGSLQLGGNLSVAIGPLGRSAEASGSVNTKGRVAAMFSYSKSKGFYGGISVEGTVLVDREDANARAYGSYGKNAKQILSGSVEPPRWATGLIQTIDRFTLANTPSKDLDGEYFNYDDTSSFDNRGLGRSGGRRSSFDSVDSRELDATVRTKSPLSKRESGLDDLPDRFDGFDLGDRKGNGADAGRSSFEAAERDRRARDEYDARPYAFGSPSSSLSNTPARVGSAASQKKRPGIRQRSSSIASNLSFSSLGGKKRLDRSGPTPPPDWNDIPGHSKISAAWGRRDPDGMDALDRELQGGGDTARRGSPYSPSHARSYSTSGVSESAGSDARARSGSVGIGGRGSLNTPVGWSQFSTADDADDLFGDSQARDPFDDLEPRHTGTSAGSGYTNGNGNGNGNGRTKSPWDAAGSSTAPPAGKTGSRFGKFRTPSPGSSAFGRKKTPTIVEDGGDDQTASLIDPEPYAEVQRRESFSLATSNAGVPVIERVVALFDFDAQEEGDLGFNKGQVIAVTKKTDSRDDWWQGRVEAGLSASRIGIFPANYTQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQA8</accession>
    <name>W3VQA8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQA8"/>
    <dbReference type="HOGENOM" id="CLU_032409_2_1_1"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="39915" checksum="2E78EB57F4F8B593" modified="2014-03-19" version="1">MRDDGSEEERVYCSSSSSTRSRSRSRSRSPTSLFEDSLFTLFSHNQPAHGDPGDVCKYTHTNLPPRKIDSSSGSAPRKATLRYRIAQNSGTNTKLFAHHQWDAGLYLADLIAEQSFVTTQSQAASEVALGKQRDAFADVRGKTVVELGAGTGLPGLVACVMGAAKTVITDYPDPHVIENLQGNLDLALLSKPNTAGNSSQRRPNPHYAEARTRVEVLGLGWGNHDEEARVYNSSLSSGGSGGGYDVVLAADVLWVSSAHPLLIHSIRALLKRDRNARCVLIAGFHTGRPAVRRFFVQLAQADTTGDGTLADGRTAGIVPDWEEASYAGIWERNIDGATRAYSDTEDDMGDISDRGSWVVVASLRWADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQD3</accession>
    <name>W3VQD3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="6">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQD3"/>
    <dbReference type="HOGENOM" id="CLU_060196_0_0_1"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000204">
        <property type="entry name" value="Probable electron transfer flavoprotein beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="272" mass="29735" checksum="D61AE4989BD354E5" modified="2014-03-19" version="1">MRASLVNQLRVLVPIKRTIDYAVKIRVASDGKGVDQNVKFSMNPFDEIAVEEAVRLREKHKDAITKITVVSVGPPKTADVLRTALAMGADDAIHVEVPDKGAAPLEPLGVSKILNEIVKKAGEEEEVGLIIMGKQAIDDDASQTGQMLAGLLNWPQATYASKLEFSGKPEKGAEAQITREIDGGLGIVKTKLPFVMTTDLRLNEPRYASLPNIMKAKKKPFKKMTLKDLGLEDQVKPRQEILKVAEPPKREGGAKVENVDELISKLKEAGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQH1</accession>
    <name>W3VQH1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQH1"/>
    <dbReference type="HOGENOM" id="CLU_1390779_0_0_1"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834794" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="19983" checksum="33812AF72697329A" modified="2014-03-19" version="1">MRTATSLAALALTAALVATGTVQSASTPIPSETSPEAQSCKVLPDILKKVLAAGVATDGKALDIADLYSEFYPAGANPTAKELYDAIPAAAFGPKDDRDGAISGSGGWDKDAVIADDGYGEQSKSTYAKDGGLPSFCRVGGTVRTSETSKSQFEVWMPVADAPVGKDAPAPEACTQIDGVDVTDVAKTFKCVSTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQK0</accession>
    <name>W3VQK0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQK0"/>
    <dbReference type="HOGENOM" id="CLU_496177_0_0_1"/>
    <dbReference type="OrthoDB" id="2409325at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="537" mass="53485" checksum="B57869BA070211AA" modified="2014-03-19" version="1">MAARPVPGAADKPQRRVVPGAPPPAPSKASKKGKTSSKAAADVKVPDAKSAALLQKAPANPNQVANGLKVTSQDLAEQAETQAAVAAVEAVQSSAAPVVDAPSTPAQKVISDRINELSAKSKNATITVAIDELKSLLSKVQVAEAGSAPSSSKAGTESEGKARLVLLLQFLHLFNLFHPNPAGPPSFAPQRIMPPALEMSTGQQVAAVAKIYDQLANGPLEGGGGDALQTLASIERGSKDEVLPDVSFDTIRSMILKLTAPPTANADADADAARAAPTGLDGPSKGFVPLGKASSPASPVSFMQASEILDQSGAEPEGGQPSAVPAEGAEESRKGEQAGAGIVMGDAAAMSGKADGTAASAVKEPVNTTVVAEPKLNWAALAEEDDGDLGEAPVWEPLPSSTTSALVTPAPGTPSGGDAAAAPASEAPASGEVANSPRTKKAKSNGGAGRAGNGAGGANGKPTTPKPKPQPKVDEDGFILQESKRTKYLQQKQQQQQRGGGGGGGGGRGGRGGASAGRGGRTNNGARGKGAPAPSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQK7</accession>
    <name>W3VQK7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQK7"/>
    <dbReference type="HOGENOM" id="CLU_1360942_0_0_1"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="201" mass="21600" checksum="4489D6992DD8D9FA" modified="2014-03-19" version="1">MSGTDKQPLMSNSHSAYRESLDDDLDPRYATESYQHQASAPASKSSNVVFDAASSLEAQSQPRSLSSTGAPSWQQQGQQGAAGGFTNSFSTSQSWSLSSICAIAWALPPFSSAFVLIWETENDLARFHAYQAGISGAALIVIVWILRSVLGLKTIGLLVAMGAYGWFWVNASTAHKSAPSLSRNPYLPHIGDIASRWVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQS8</accession>
    <name>W3VQS8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQS8"/>
    <dbReference type="HOGENOM" id="CLU_019414_0_0_1"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="441" mass="50192" checksum="CA1233ED513ACC45" modified="2014-03-19" version="1">MAEVGKPRQIRIEFPEAELDRLQHKLDDAKLPDSDITGGLEPWEYGTELSKLRQVLADWKRGNPKDNNRQPVGSPDQGVKAWWRNVEAELNRFPHYKVQIEGLEIHYQHFKSASSDQDADTPAIPLIFSHGWPGCFTEAFHFASKLVESRSPRFEVIVPSLPGFGLSQGPLKKGWTLQDSARVFDTLMTSVLGFKSYMAQGGDWGSIVTRFLANSPNCKIAHINFAPPQLPFWTIPALAIDQAVYPGFAAGSLKLLGYHPDELLGIERSLKYLEQGNGYVKIQGTQPSTIGYGFYDNPVGILAWIMEKYHAWSDPRCPAFNESTDTASPHSYITDHEMLVTVMIYYLTNSIHTSFLPYKESLQMFNKPDWKLWEPAKHKPFGFTAFPYEALAGPRSWLKKYRLNWQFFKRRDYGGHFAALDAPDALVEDMQEFANQHWPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQY5</accession>
    <name>W3VQY5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQY5"/>
    <dbReference type="HOGENOM" id="CLU_007383_8_2_1"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="310" mass="33159" checksum="9BA9A67B0D7C1561" modified="2014-03-19" version="1">MSAKKLLTIFGATGNQGGSVISTILNNSSLNSKYSLRGITRDTSKPAAQELAKKGVEVVRADLSDPASLKQAIAGSYGVFAVTNFWESMDGAKETQQGRNIVDASLATGVNHLVISSLHSVNKLTNGSLHVPHFDSKAAIDEYAESVRADKLNASYFHAAFFLQNFDTMLRKGDDGNFSITLPIDPAARVPLIDIQADAGKWVAGLFEAGAAANGKTVQGISFWTDMQTFAADLAKAIGSKVAYNNVPADVFKSFLPEAIADELTENMKLVDQYSYYSKGAETNQPQSDALLLKGAQLATVQSWAKSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQZ1</accession>
    <name>W3VQZ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQZ1"/>
    <dbReference type="HOGENOM" id="CLU_110381_1_0_1"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17614" checksum="E29C875636B75C85" modified="2014-03-19" version="1">MEPTMMIQQRSASAHIAECSNASCGDEGVAVVVVKTFELQSKSKGDLTKQLEELKTELLNLRVQKVAGGSSSKILRINSLRKDIARVLTVMNQKQRANLREFYKGKKYIPLDLRAKKTRAIRRKLNQHERTRITERQHKREVHFANRKFVLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR08</accession>
    <name>W3VR08_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pep1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR08"/>
    <dbReference type="HOGENOM" id="CLU_1533721_0_0_1"/>
    <dbReference type="OrthoDB" id="2553351at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833190" description="Pep1" evidence="2">
        <location>
            <begin position="32"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="18808" checksum="B9CE279ED27D11DF" modified="2014-03-19" version="1">MRHLHIGPTLTMRFMLATGALFALASMLVSADDAMPLPNYTPRDEPIASTFYWFSSVEVGVCYSPVARVAGIKGAIHCTHQGNYDVDNNTWTLPQTCVALKPLGSELSTAVRDSCKNAKGTFNVIKPASANAAGTQAANAISKNGAGAGAGGDAGADPSSDGSAPDSNDKEDKGFLGNLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRC8</accession>
    <name>W3VRC8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01354</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRC8"/>
    <dbReference type="HOGENOM" id="CLU_005912_5_0_1"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833314" description="Sodium/hydrogen exchanger" evidence="12">
        <location>
            <begin position="23"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="81"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="723"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="811" mass="87333" checksum="10BD8E9ADC96F39E" modified="2014-03-19" version="1">MLPRMLAKLTMVSALLLSVVTAASTSNSATASTTGTATSTASASATATATTPVTVPDAEQQERFSSLALFLVLSLLILSFWTSYYLKVKRITAVHETIVGLFAGMFVGLCLRVGPGEQVQSMLSFSNTIMLNVLLPPIILASGYDLRQENFFRNFGTILIFAFAGTFISAIVVGVIVYLWSLLHLESISLTLLECLIFGSTLSATDPVTILAIFNTYKVDPKLYSVIFGESILNDAVSIVMFDTLSTFRGKEIYISSIFHGIGLFLVVFTLSMLLGVCFGLGCSLLLKHSRLSSYPQLESCLVALIAYTSYFFSNGVTMSGIVSLLFCGITLKHYAYHNMSRRTQRTTRYTFQTLANLSENFIFIYLGLSLFTQEILVYKPLFIIVTVLAVVASRYCAVFPIASVVNAVKRARNNRRARATGGGGVPRGAVEEELPRQYQIMLFWAGLRGAVGFALSAGIEGQNAIALQTTVLVTVVLTVIVFGGTTAQMLEILGIRTGVQDDEGDSDDEEDDDDVMRLRGMQRRTYLDSGSYRDASERAGLTRSGRKAAYRDASETSSPRASLSHSSSVFASGMRGAKTGGARTGFADDLEEDDERSSFSSEMLPSRSSTPGAGTGLAPLATGASLSRSATPGLAGARSPTTVNTTSIPSLSEIRKAVLEASSSDGSTSSPAKQLLDRAGLVMKDGQWFQAIDQKYLLPLFSNSVASRKHEEKKIARLAARDAAASRSELDLSRAGDDSTGSARRNFFSVEEEGDANAYPSERDAVVVDEDEDEEQATPIFDATSFASARRSTSGANTPTRRTFSHDNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRD4</accession>
    <name>W3VRD4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRD4"/>
    <dbReference type="HOGENOM" id="CLU_007383_19_0_1"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="336" mass="36151" checksum="A52299AB5093E52D" modified="2014-03-19" version="1">MATTVLITGAGGFLGSMLADTLVRLQPQHTFQFVLVDVHPPPAPKTSGVKSVCLAADLTTPAGVKSIFETELGLPAVIYSLHGIMSKGSEDNWDFGFLVNFDSTRALLDQAKKLTPGVKFIFASSVGVFGGKLPAEVTPDTYPRPESNYGTAKVMCEYLVTEYSRKGFIDGRAVRLPTITVRPGAPAAATTAFVSGIIREPLQGLESSCPIGKSADDPVLETTKLWISSPSTVLENFVIAKDILAEKFPKYSRAVNLPGFTVSVKQQIEALRKVAGDDAVAKIKFEKDEVCERLVATFPAVFDNEFALSIGFKVDQGGFEANVKEFQEFLASQKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRE2</accession>
    <name>W3VRE2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Levodione reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRE2"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32103" checksum="3D58230267EA5715" modified="2014-03-19" version="1">MAQTKNEQQKKAYEVTLQRLDRIRNHLDSRPRSGRLAGKVAIVTGCGSLAGIGRATALQFAHEGVKHIYVCDINDDNLPALKETISQRYPDVQCTAIVSDAADEASVKSIIDQSLADNGRLDIFFANAAIATGAPISATDVEDLERTHHINVTSCFLACKYASEAMAVTSPSKPESSGSIIMTASVAGIRSGAGSVDYSASKAAVISLAQTTAWQLQRTNIRCNAVCPGLIETGMTLPTFEMARERGTAGKIGQLNPTARYGVAAEIAHAVTFLASDEASYVNGVALPVDGGLAASLPVVPGKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRG0</accession>
    <name>W3VRG0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRG0"/>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="190"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="553"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="770" mass="85249" checksum="85AB6B3B0654A3A8" modified="2014-03-19" version="1">MAAATLIRKALPKLDDPVVEYLDGYINDAADDPTEDLFETVVKPMLESACISDPSSSKQVSALLPKLLELIQSKLPDDDADAAKASGLTRLDKVVDMRNTEMSRTSGFDTAGGVDIALGTTKQNRSTVDVKKLEKQEAKTRAKLAKRAQRDLYESSKLVQQSKQQASYEELFLKVNPLESMGNKGKNKDIHLPNIDVSFGSNRILSNATLTIKAGRRAGLIGRNGVGKSTLLRNMALREIPIPTQISILYVEQEIVGDDTSAIESVLKADVWREKLMQEEAQLNAELQKLEESAAAAVAAANAAAAAAASQSEGAEGEEAAAAGLSRGSAVDMPTRQREIKREELSTRLGEVQAKLVEMEAETGPARAAALLNGLGFKTDDQQRATKTFSGGWRMRLALARALFCKPDLLMLDEPSNHLDLNALAWLEDYFVNDYEGTLLVVSHDRAFLNRVATDIIHMHSERLDYYKGNFDQFYQTREERRRNQQREYEAVQLQRATLQAFIDRWRVNANRAAQAQSKIKQLEKLPNIEPPEDDEVVHFRLPEADKLPLPLLQISNVTFGYRPDKLLLKGVDFDITQQSRVAVVGPNGAGKSTLMKLLMGEITPLQGDQKRNGKLRVGFFSQHHIDQLDLNANPVSFLASKYPGKTEQEYRSHLGAFGIKGMTGLQKIATLSGGQKSRVAFAHISMMRPHVLLLDEPTNHLDTEGLDALCEAINRFNGGVICISHDETFIHNCLHELWVVDGGRVEKFKGDVAEYKRIILSKNKSTARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRG3</accession>
    <name>W3VRG3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRG3"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="364" mass="38741" checksum="DEE0189D45FAB991" modified="2014-03-19" version="1">MVNKAVRVTKANGAFVETQAKPFSASDLDADEVLIKNVAVASNPKDWKLALYGLYEGIEGNDVAGHIAAVGANVRHLSKDDRVIAFTRMASGDKYGAYQPYTVAPAWTTAKLADNVFLEDGATLPLAVTTAFVGLYDKLGLPEPTSDGKPAPEADKATVLVWGASSSVGAYVAQLAKISGFNTVAVAGAARDAVEALGIPASKIVDYRAERATVIENINKAAGGSAFTHVYDCISTQETVNTIVELLSTPPNQGGKVTTVLNSAYDDADANAKLSKEKGISFDRTMCGSVHADKKEFGTRWFKQVTDWAEEGKLQPNKVQLLEGGLDGIPAGLKLLQENKVSNRKLVDKDRRPGELVIWTAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRJ9</accession>
    <name>W3VRJ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRJ9"/>
    <dbReference type="HOGENOM" id="CLU_074889_0_0_1"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="221" mass="25196" checksum="2F85C67688914FE8" modified="2014-03-19" version="1">MMRADNPDDALGTSAPPQIEQFLAHTNRLQQRYQSFLDTTTPYPLHRWGATAGLLMLFMLRIVLSQGWYIVCYALFIYLLNLFLAFLTPKFDPSYEQDLAEQDVEEGEPGLPTSNSKSAASGGLMSGVFGSSLNGQSGDDEFRPFIRRLPEFKFWLSATQAVVLSLLATTSSAFDIPVFWPILLMYFCILFTITMRRQIQHMIRHKYVPFDLGRKTVYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRK7</accession>
    <name>W3VRK7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRK7"/>
    <dbReference type="HOGENOM" id="CLU_130474_3_0_1"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="96" mass="10738" checksum="7B9A7B628B0113DF" modified="2014-03-19" version="1">MLIFSAFKTLTGQQVTIELKNDLAIQGTLKSVDQFLNFKIDNIRVLDEAKHPHMMAVKSAFIRGSVVRYVHIPAAAVDTQLLEDATRREAASQAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRZ1</accession>
    <name>W3VRZ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-rRNA-processing protein RIX1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRZ1"/>
    <dbReference type="HOGENOM" id="CLU_296487_0_0_1"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="905" mass="94657" checksum="F63B2283F3F19A4D" modified="2014-03-19" version="1">MPTMASTYGAAGRVVVGAAVFELPGAARTPARLDLLLNLVTSSSDASQADEVLRLIAQSGLLAQVPHDETQHKLTVRINALISSQNALGYRLAHAWIQQDPAVWNEHLIANAATWTTQILNLIGAPEKLLHQRANSDRLLAAALQFATTHIFPENIAARQEFYRQVVHPNLPKLVVGLAQLLDFILKRVSDDGQIAHASQLHVVLVFINRLMHAHPAQFRPVSARIHECISSLLYADDAQSLAVPIFTAAAEVLASLHLTGALSAKGSEASGGNARTTQAQLWQATIENQLHLATEAWRFATSSYQATEAAQQGESNAGAARPQSLKAYPKDPLAATRVAHECLALLLGTRGRPGLISLHLRAATARPVPVPAGKIVSLCLDMLHVDVSSRFKPTAEAKLCTLQASHLAALHTRALALVSQLALVAPAAIPLEAARLLGDVCRLAEGGGGAQASARVRLAAMRTLVVLVGRQGIALPLDPAGRTTLRLARLAVTQIARAVLQPAGASGDAARSAKKARLYESDSLFTSGSAKDRMHSLAPEEVACTIAALHILVAVYPLLTTSLSSVHYDLMQLAVHNVQAMVEVLSDSIGTHSSSLRAASAGAGIPSTAELFEEAVGALGDMCLDSTSSVLAMVLPRAIAVLGRVANAPSGCSGRVRVAAQRALVAVHASRKGKFVPVARGVGFGPRAADDLDAIPDGAKLAGATALGRSIPAAESVESSLEEASTAVLGKRQVEQEEEEVVVGDRMDVDAIAAESNELFQAGGADASTSVAGGALGLGRPGSPLRSPVEKRIFSPDPVKPIHRTSTPRIGSPSTSHPRALSRPASPTPDQPAPSMLTPGRMVSPTAIASTTTLVAEEPTVGAVQEAQPAETAKPTVQIGAASEDDDDDEMPEIDMSDSDSDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS61</accession>
    <name>W3VS61_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS61"/>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="336" mass="36697" checksum="32C08CC95A1B843B" modified="2014-03-19" version="1">MSTSTAAATPRAPPGELLIPLHVAFVEALDKKRDSLAYHFTTHLRMNGVYWGLTALEILGRPEVLDRQALIDFVFSCWNDDTAGFGSFPGHDAHVHSTLSAIQILAMKDALGELDTRGVRGRLVQFILGLQLPSGAIQGDKWGEIDTRFLYCAVSALAHLGALDQLDRDRTVRYILACHNPDGGFGTDPGAESHAAQAWVSVGALSILEALDEIDCDRVGAWLAERQLPNGGLNGRPQKLEDVCYSWWVLSTLSVIGRLHWINADKLKHFILSAQDSDEGGIADRPDNVTDVFHTVFGCAGLSLLGFEGLQQVDPTYCMPLRVTRALGIDRPFQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSB4</accession>
    <name>W3VSB4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">AIM41</name>
        <name evidence="8" type="ORF">PaG_00988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AIM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSB4"/>
    <dbReference type="HOGENOM" id="CLU_393359_0_0_1"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HBS1-like protein N-terminal" evidence="7">
        <location>
            <begin position="293"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="493"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="701" mass="75289" checksum="A557AAE800578812" modified="2014-03-19" version="1">MPAISSREWMTLAKLEDISANQRKDLPKDQVYLRELTAEEVAYTDMGGYKGRVFERKNVKISIETVPDERPKIVETIPDHGSPKAAKPVLIDITEWRAAFQNVGSNLRPPSAFDENAINMLLRQALRNSHALRSQLPRSIEASTLRSSHPLATVPVCIRFASTEAPAAGEDAEAALLAKVKSGIKEAMKAKDSLTSTVLRSIVSEHQYSSKQKGNQVSKVSKLVTKAIKRRQDTAKQFRAAKPPREDLAEQEEKEAAVLEKFLSETKPGWEFSAASLHNMSRHRAVRNLDLDEELAEDDYYDEDPYENLSPEDNDAMIEAYSQTLDVLGPTSTNGFTEREIKDVLWDAYFDVDTAVTQLVEEKSRREAKAERERQKQAGASALPDDDGATVEAFKALSLQRDRRAEIRAGRGMSRGRAQGLRGLATGGRSGMAKRNLAGLAPDFVRDAQPPAASAPQKPLSKLSALAARSSAKRPAEAPPANAAERPRPASPAPSASSASNPAPVAGTSRPSKLAALAAARNASASSGVKPAPVQSQKAVEAVPTETAPKPLSKLQQRMAANRQQREAATPEAIEAAAAAAAEEEAQARPQTCYGSDLPISSLFPTEPSASGAHSDGRETSRAFMAPVSAIAGSAKDATDQLVAPLERLKPVPGGSPFAIYSHAAADDASPQIELVRKAFAGPSPDDVVMKAREGTRLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSC3</accession>
    <name>W3VSC3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal biogenesis factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSC3"/>
    <dbReference type="HOGENOM" id="CLU_052213_3_0_1"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35178" checksum="6532B778CCEC3F86" modified="2014-03-19" version="1">MSKPAPAASALRRPTPRKLNPTDKILGCFSNVEPSPRLDHMIRYLSTWSGTDKALMLTQYSSKLVIVLLNLQYALRLRMLGIKSTKSSSAAQRVQKLSALISDARILYRIWGILPIFKWMIGLERSPPPTRLLHNIERIQGWSMLAYCPMEALAYLGSHGVLPVPAAIQNSFWLWGSRFWALYVGLQLLHLVEDNRLLRLRAKALERSRGHPTPNKIQLKPNGLVADASTPSEKSGSASQEQVITRRMWDELDDRKAAILNELWVNLGYLPLTIHWSCATGIISDGWVGLFGTIAAMAGLRSGWKNSAAPPVPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSR3</accession>
    <name>W3VSR3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSR3"/>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="326"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="551" mass="62742" checksum="1530FC59B18092BA" modified="2014-03-19" version="1">MSAAEKKQEADFSADVETLIPEAQSLAASNQLSAALERVFALEKKARNAADLNSTTRLLLLACLLVRNTPSPQQTNWDLLAETVTSLSKKHGQLKMATTRMVQLVMCFVYPAVDPEEERRREQEAKDEEMKDLAAEKARKEEEKAAKKEKEEGKKESKEAVEARRRQEAQEEREREKVGAQNAKVLELMDAAKRIGDTGVTEETRMKIVELLRTVTEGKIFVEVERARITLLLSKMLYTKGKVSEAADALQELAVETFGSMDRREKVEFILEQMRLNYERNDLAKMAIVAKKINTKLFDNAKHADLKLRYYGMMIEYALCEDKFLDICKYYREVLATPSVQEDDARRKETLRNVVVFLALAKYDNEQSDLMARIEAMEDLDQVPEHKNLLKCFTTPELMRWPGIETLYGPMLRETATFNAATPAAKSNAGAGAATVRDGNHRWEQLHKRVVEHNIRVISRYYTRITLARLAQLLDLSPDQSEQALADLVSGGTVWAKMDRPRGLVTFEKRRTNADVLNAWSADMSKLMDTVEKVTHLVEKEWAIHRAGIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT27</accession>
    <name>W3VT27_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT27"/>
    <dbReference type="HOGENOM" id="CLU_040729_4_0_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000306">
        <property type="entry name" value="ADP-ribosylation factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="289" mass="31111" checksum="4E137C623264C0E1" modified="2014-03-19" version="1">MGVTFSSMFSKLAFWNKNEDVRILMLGLDSAGKTTILYRLQIGEVVSTIPTIGFNVETVTYKNIKFQVWDLGGQTSIRPYWRCYYANTAAIIYVIDASDTQRLGTAKAELLAMLSEEELRDSKLLLFANKQDLPGALDEGQVSEKLGLSELKDRQWSIHKCCATKGEGLEEGLDCFKTGAAMQSTSAAIAAAAISGADLGARANSSKGSSAATIGSNGFDASEAEAWVQARWKSVQTSLNDKKIPDTQRPEVYKAAPGTGGSAWGPNKKTVNERFANDLVKASTAAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT32</accession>
    <name>W3VT32_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT32"/>
    <dbReference type="HOGENOM" id="CLU_1251137_0_0_1"/>
    <dbReference type="OrthoDB" id="10252944at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="221" mass="24550" checksum="FB115DA0732A1121" modified="2014-03-19" version="1">MYLDDMLDRRRSQVFDRDVLPPVLSPAANDYFLRILAFLSGFVAAVLSIEVEEAETKLLALDVSGCLFLHSFTALGLLGGPAPFMALLLDKDPGPKPVHRMSRATRRKFDHCVEVARRYEVHPDRMPADPGLPTELDIVDGLPLPPPDPWSLNRVEYSNVIELFFDGVSERFHLARQSAIHWVGGTIVPSSVATTAHYMGKGHGMLRAPFPGCSPHPHVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT68</accession>
    <name>W3VT68_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT68"/>
    <dbReference type="HOGENOM" id="CLU_047332_2_0_1"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="194" mass="22034" checksum="47CD17DCD3376BA9" modified="2014-03-19" version="1">MTPEEYEALSPEQQKQHDAAERAREAAEQAELPYTWKQQLDAVEVSVPVPSGTKGRDLVVELKKRKIKVALKGKDAILEGELAKDIKEDDSTWTIEDGNLVEIHLEKMNKNEWWPNVVSHHPRIDTTKIVPENSKLSDLDPETRAMVEKMMFDNRQKAMNRPTSDQLQQQEMLAKLAAANPNIDFSNAKFNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT92</accession>
    <name>W3VT92_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00712</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT92"/>
    <dbReference type="HOGENOM" id="CLU_000604_6_4_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF648">
        <property type="entry name" value="ABC-TYPE TRANSPORTER ATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="360"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="676"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="917"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="920"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1040"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1102" mass="119443" checksum="DF2E6780C7806A1B" modified="2014-03-19" version="1">MLASSSQRAWPQASPSHDDYDQALTVLRIVQPAAILAIALASVLIKPSKKWLAHLLHPRRSEYDQLRAEAHREHDDDDDEPPQPTPVVVPVRSRRRFLTQSTQLGLAATFFASGVLIILRAVLPPKEWQPDLALWGAIDLQALGGLLAWGAIVIAALWEEKVRGRGSYGRGKSGWSLLAGAATDICLLVLYMITKQRRDLPNTSRWSIAQLVLIILRLLLLYPVLILALSWDRVRFVRAADLANETGVGSAPGPSTSPARSAPANAESAGLLQAPGASATPSYGATGSSVNGANGKDSAKKNSAGNSGTQTPNRDPNASMGLSVATAPPPPTFSTFLYRIRFLFPYLWPSKSAHLQLIAVACVGLLFSARVVNFFTPLALGRLVEDLSQGASPWADVAIYAFLKMLQGQGSLLTVMQNVLWVPVEQYSDRMMSMMAFEHLLNLSMSFHTKKKTGEVLRILDRGSAINNFFQYLLFNLLPVFIDIFVAMIYMTRTFSPAIGIALFVVMVAYTWTSVQLTTWRTGLRRAMNNKDSICRAISADVLMNWETVKCYSNEGYEAERFRSALQDYQKAEFKVIGSLNMLNMVQNLILAFGTLFTIMLVAGSVVRGETTSSQFVVFVTYLQQVYQPLSMLGTLYRVVQQNLVDTDKLMTLLEEKTEVKDVPGAKDLVVTDGVIEFQDVRFSYDGKVEALKGLSFKIDRHSSVALVGESGAGKSSVLRLLYRFYDIQSGRILIDGQDIRNVTQRSLRRAIGVVPQEPSLFNNDIRTNILYGDTKASDEAVEAAALAAQIHDRILSFPEGYGTVVGERGVRLSGGEKQRVAIARTILKNPPVLLLDEATSALDSQTERQLQSALNNLMHGRSSLTIAHRLSTIINCDNIIVMDAGRVVEVGSHAELIAKKGAYSKMWEQQIKTQKEQEAAAAAQEASRQADQDAQPTEAAKPSAAAMTAEQDEQDEPAEAQPGMLGIVPPAVTGEPENPLEGAGDNVEPADGAQGQGAAEGGDVEAPSQTEVQAAAELAKSTQPGSDAGANGNQGGLTVESTTATNGDASGASSPSLQDDSPSGSDLASSGTLSKDDKKKQQNRKKNAKRREKERQKKSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTD5</accession>
    <name>W3VTD5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00682</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTD5"/>
    <dbReference type="HOGENOM" id="CLU_006187_2_0_1"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="137"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="667"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="98405" checksum="01CA4A78EA177814" modified="2014-03-19" version="1">MATHDYGRPSTDDHAEDRPLLREEHDGADDAMHQSLWSRFRRQLSATFAPLAKPEELRPLERFLVVASVALLLLAAVFIGLFAGSQHKLAHRPASPTPVPAPGNPNPNPPEGDICTTKDCVLAASEILRSIDESVDPCDDFYAFSTNNWLKSHPIPGDAGLFGTGQFVLSENSKILRQILADAPSSAQLDLHADQSSSKGNDQDKQQHEADRQNLVKLKDYYDACIDVKAQDKLGAKPLLDVLEHLRLLIRQAGPDDDEISEPSRFLLQVDDRSEKPVPPNQPPARSPKPHPPRESPKPPPPSGKRQKGLTEAIAWAHSRGLPAFFDITIDGDAVVDPTAATPWFFPSGLGLPDQSYYEDKDEIAFYKRVVADGLAVYDRELKHVKASGKKDKRGKSAPLGPLAEHVVEFERLLADITPDSEEVNDPVASYNPINTTALPYTFSSISWPAYFSALTVRMPERIILTSPKFVTALDALISRTKTDVLEAYLVWTAIREFGTALGPNVKLRGPAERLDRYSKGVAPDAKEDRETKCMGDLNAALGFMSGRYFVRSAFQGDSKKRVEQIIFSVIDAFKSRLPELDWLDEKTRKKAHEKADAIRVMVGYPNAPNTTDAVSVSAFYRDLPVDASNYFANRLASSTRMAKRDWAQVGRKLNRELWDMFPAEVNAEYSPQGNYILFPAGIMQPPYFHVSWPSYLQRGAFGAVAGHELSHAFDPDGRLYDKQGYLRDWWSEATAKQFQQRQTCLANQYHSYTVSDGKGHELHLRSNFTKGEDVADAGGLAQSYRAWRDELALGGDEVEAANALLPGLGYTREQLFFIAYGVSWARNIRASEQVKRLRTDPHSPTKYRVNGVLVNSPEFAEAFGCKAGRDKMAKTPEDRCSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTD6</accession>
    <name>W3VTD6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTD6"/>
    <dbReference type="HOGENOM" id="CLU_845018_0_0_1"/>
    <dbReference type="OrthoDB" id="10441580at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833274" evidence="2">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="329" mass="36503" checksum="F1FD48A4FFE1EF7F" modified="2014-03-19" version="1">MKIFGFAFFAFLATVVAIVNAAPPMPAVVANSDAAVQALWTKANGGMFANRLAGEFAYLQDDWAHFLSTEGEGVIMDFYNRFFQGSPAAFRYHGGSKLLKMVKFEDTKPYTFNTETDVLKPAMAAGLVEKFAEHLATKRGGSSARQMGASVDTELRLGRGLVLGAPMPPSNLDGLEPGVKYLWDSALVGNLHASLLQFDRGLHNAWRAFLNTKGREIVEQHFAQFDEAIRAGKSTIMGVVESEHPSLINVRYHDQLQPLSIKIVRAFAEERMARQYRLHRVTLRLIEEAKEHMRAEQERRESEEWKGWLNDSDGEAGPSSAAGRAPSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTL5</accession>
    <name>W3VTL5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Folylpoly-gamma-glutamate synthetase</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
            <ecNumber evidence="10">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="ORF">PaG_01383</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="36">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="29">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="30">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="35">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EC" id="6.3.2.17" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260257_0_0_1"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0347">Helicase</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="24" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22 31" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="33">
        <location>
            <begin position="820"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="34">
        <location>
            <begin position="1031"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="625"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="750"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="981"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1121"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1215"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="773"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="1146"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="1180"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="1219"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="ETS64147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1316" mass="140314" checksum="5E1BB887ACF78C0A" modified="2014-03-19" version="1">MPYIGHLWHQCFSTRSRSMRRSLARSLRRYSHSDRPSICARPSSAPVLQFGHLRLLSSTPSIVASASPLRTSRAMSSAQAESSSAATATSTRTYDDAIEALNSLQSNAATIEALRKSGGRLLDFAIPEMVEYLERIGYTTSDLNKLNAIHITGTKGKGSTSAFVDSLLRQLTPVCASKPPKVGLYTSPHMTSVRERIRIDGVPVSQELFTSYFWQVWDRLEQNPTRKFDLTPLRPVYFRFLTLLAFHIFISEGVQPVILEVGIGGKYDSTNIVPRCVVAGITQLGLDHTAILGNTVEEIAVQKAGIFKQGAPAVCWAHQPGSAVDEVQLVASEVGVSGLRMVDVHPALVAGAPQSVQLGLPGVHQRTNASVALELVNAYLESQAGRSAYTELAHRGAAGELAAWQRKGLEDARWPGRCQTVPSARSDAALTWYLDGAHTTDSLSVCLGWYTATQQQQGQSRRKKRIFVFNCTNGRNAHELLSSVLDAVEASLRGGEEAASTKAGTDGYALAKDYFDEAIFTTNITFEGGGWSSELTSKLLDDAELVNLTVQKQLAETWKQLVPGSSTEVRITPSIQALHNHVVELAQKQQGQAGSVECLVTGSLHLVGGVMAHLQHSGCLDDRLVSTQQQQQQQPQQHQHQHQHQQTFTTPPRQPASLRSPTILTSDLPGQPGFSSQNHPHSPNSLGQSAAARFERFFPSSPNTSSSNPSSAGQTFTSSIGSAAGLATNSAFGSFGHSLAPGSMNASSIGSGHFGSSHNGPRKASSRAAIPAQWSSQDPSALSTAPSGTSPPKSNNPLLQAYPAHDANALASGDDDVIPTAIVVKNIPFSVKREQLLEIIGDLGIPMPYAFNYHFDQGIFRGLAFANFRSAEEADAVVAALNGFDVSGRKLRVEYKKVLQAGEKERIEKEKAIKRMQSMQLEKERERERRRHQDDYAANAYLMPGFGSANAADAYALDAGAHQPAFEQGVRAPLTADSLRKVPSSQHLSAGAGRPAGPPSSSSNPTAAAANGAAGAAGAASAKKEELDLNDAATLEIYSRVLLFKDDRMRDELAFSRSLTPMERRTVHLVAQRLGLFHYSLGDGDERYVIVTKNEVSAPARPLRSQASTIGRTHRTAGLDGASTGGFLGPGSAATTGRAGLRMKKSAPDMKRGLGGDRDGAGYASHGHGAGMGGALSAHRSNTNLRDGYSSTMGRRTQASAAGGAAGLQNLFAQSDAAPSSQSGTESSSHNSSPTHSSLLRQPRGPPAPGTDLRNFAVRSRVSTNSSNSSALPVVTPPTAPVGGFQLHINGSPSKAHNAYPGLDHLEATSHQPLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTN7</accession>
    <name>W3VTN7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTN7"/>
    <dbReference type="HOGENOM" id="CLU_003041_11_3_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="306"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="515"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="698" mass="77513" checksum="C9124DB995D43A06" modified="2014-03-19" version="1">MSKKQPLSVAEILEKQKQESALKPRFLSKAERAQKAQKEKEEEERKRALKQQEDLRKRQELESQARSVASSSRQADSSHARPSERHHRDTNDLDYGSAEPRHDSTSRRAREANGRHLNGNGTRAANEASRDATPALNPSDSSSAPLTEAEQEAIRRRYLGLKDDKKKPRRKPTDKKFVFDWGEDDDTAADSLAVQIQSAAQHAAPSHLVAPRANGTGAPSHVDPLEASLGRAARRFDDKHWSEKTLEQMKERDWRIFREDFGISARGGNIPRPLRSWRESSIPPSILATIEEIGYTEPSPIQRQAIPIGLQNRDLIGIAETGSGKTASFLIPMLAYISHLPKLDENTKALGPQALILVPTRELAQQIEGETNKFAPRLGLRCVSIVGGRDMNDQAYALRDGAEIIIATPGRLKDCIERHVLVLSQCTYVVMDEADKMVDMGFEPQVNFILDSLPVSNLKPDSSVAEDPLQDGVGKYRVTMLYSATMPASVERMARVYLRRPATITIGNAGQAVASVEQIVEFVANEDQRRQRLISILQRSSHLVPIIVFVNQKKAADMLSSSLVRAGFYVSTLHSGKMQELREEALAHLRDGTTQILVATDLAGRGIDVPNVGLVINFAMPNNIEAYVHRIGRTGRAGKTGTAITFVDQADSDLFYDLKLELTKSKLSTVPQQLARHPAAQHRPIKDSHAKRKREDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTP7</accession>
    <name>W3VTP7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00363</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTP7"/>
    <dbReference type="HOGENOM" id="CLU_076902_1_1_1"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="226" mass="23470" checksum="DAC61D6B03690C43" modified="2014-03-19" version="1">MPPTKPKGGKMMSLINYRLRITLNDSRQIVGQLLAFDAHMNLVLADSQEYRKIKSRKAKARAAAAVEAGKAAAEDDEDDDAAMAGAADVVLEQKRTLGLLILRGEHIVSMAIEAPPPADDRMQPTMQPGPGKGAPMGRGMGLAVPPMAGAPPPMMGRPMPYARPPMPGPPGMPAPGGNMPVGPPPGFRPPGFPGMPGGPPPGFPVAPPGGFPPRPPPGFGMPPRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU51</accession>
    <name>W3VU51_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU51"/>
    <dbReference type="HOGENOM" id="CLU_836772_0_0_1"/>
    <dbReference type="OrthoDB" id="2552038at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="341" mass="35892" checksum="125E1F8CF72637E6" modified="2014-03-19" version="1">MSAAAETLTAAMAAEVQAAALGVDASTLDTTSSPISLFASPALQEAPSTDHGRSHTSSCPRLSLVSAGIPNLGAMAHGPADHEDDDEFVDELALDLSPEVCDRLEAESVRDTTQAEAVSHSEHDGGMGKKRPCSITCFDALDDNVPAIKRTKIATQAEPIKPFFEEAWVQQLLTGRDRAPAPLPPEESPTDASAIDAAPTDAIPADASPTDGHTQLPAATQKVAVVQMTPTEAVDSSPSTSEDGFCLVRVARTSSDAVPSDEGDEDVPLALLSSAARTNEPGEPEPTAVLAAITKVRDAVRELQRAYRLETLRVAAHITEQQLAIDQLRAKLRTRKPKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUB4</accession>
    <name>W3VUB4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUB4"/>
    <dbReference type="HOGENOM" id="CLU_024083_0_0_1"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="634" mass="64318" checksum="B90A5B739929E982" modified="2014-03-19" version="1">MGRKKIKIQPIKEDRNRSVTYLKRKAGLFKKAHELAVLTDSQVAVIVFGHNGKLAEFCSTDIDLLLLRYTEYDGAAERKGPQHYFNLDKDSDDNDDNDDNDNDGPDSGDGPDDSFASHSGANGSTAGRGSTSGASGANNSRSTPRTSGVKRKAEPASPPRTTRAIGVNPAPANMDQGGLGAVNPLMGASATAKQTVNAAIRQKSQSRTGGHPAASGQLAGTHNFDAFSFGQPFAPTAGIAQGMPGGGFGGMLQLPSQPSSSGASATNLTRAQTIANMSIPMPSSERLPFFVQPATPGFGLTPGGTVTTPGGRRFSFSDVLTRGSSATALQRPVTANSLLASNFQTMDAFSFATTPAAAAAHFASISPSVTPQPPAASLSAANTDAASRLEASPTPFPDLRSNAHLMTRPASTGMPPTGNNSFNHLGFGQAAGSSLAIGPNAADLHTDSPANISRPFTACANLDAPSASNHLAPPNAFSGSLGAPGMHASSASPMPHAASMPGASAIMSSSYGASPYATAAAELKPSVTPLSSATPELIQPIVHAAPAAVPSARAASMSTDEETPPVSRVAAPLDGAKAGAGGPWPTSNATFGRKPDADGSGQATLVQPVPINPIQPLGSVPFDLNFAANPTTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUR4</accession>
    <name>W3VUR4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01011</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUR4"/>
    <dbReference type="HOGENOM" id="CLU_292741_0_0_1"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="871"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="907"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="940"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1040" mass="113105" checksum="839DF92EC6F3517F" modified="2014-03-19" version="1">MSQQAGASSSSTSYTKYASLPDVDTSAPDVYEYEGPSRTDDASQSRRHRSRKHRTQGGTDAADSDSSSDDSDHSAGHRKHAGDAKGAVKNEDIDSSSLKRSDAASKFTGATDLDADAVDFSGRLRHRSARKNRAARPIDAGVETATYALDDARPAGERAQESVVDRLRRLRFEASQLEEELKAEGSGAAGADIANGSVEVDSTQMLNQLKLLHDQLARLPSPSDQVGAASSSRETDQQTFRALLDQIKQAPSAVSATDAGATPAAGTAPAKTTAETRSAEVVQLEARLSELESTLGVHEALLDESKPVPRPVLSTLSRLEHQLSLLSQPRHLDAISRRVKVLVTEMDRANDMRRKLTDGVAEGAGGDAASKTAATLTPAEMTKLQQVFDVSRRIEPLLPLVPSVLERLQTLAELHASSAHFGSVLDALEQGREARQAQQNELDELLHKMEANMRQNSQTVEANLAALQQRIEDVSSRMQKLHKSFFLPSRHRPSCLATTVFSFSPSVDSPYDIDVSYWQLALASMASVPKTDVEQPTPATDFKDDSTSESILSDYKRTIERHVLLRRLDIVAQKLNRFYVESVGIRPLALSERTGTDWWSPSLVWFSSNVNVLSFSAGTLVKLLEMDMRSAMLTTLFVGAFCSFFPAYFSLFGPKLGMRQMIQCRYSFGYFGASVICVLNAATMLGYCILNSIVGGQTLSAVSSRADGTSTLTPDVGIVVAACIALVVSFSGIRVLHMFERFFWLPTLICFMILIGEAGTGPNALHVASNEPKATAQSILGFAAIIAGFVISYSALVSDVSHYLRPDVSPHKLFWSVYCGFFLSCVPFIMIGAAFACSSYDNDEWSTALGVSSGRFFQLILAGNLGNFGRFLVVLLALSVCGNISATIYSIGLNFQTMLPFLGPVPRFVWPLLATAIFLPLAIVGHDKFYETLTDFTSVLGYWASLYVGVVFADHVLVRRRDYASYDVKHWNQWNKLPPGLAALGACAISLAVVVPSIDQVWFHGPIAKRAGDLGFETGLAASIVLYVPLRMLEKKVFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUZ4</accession>
    <name>W3VUZ4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pathogenesis associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUZ4"/>
    <dbReference type="HOGENOM" id="CLU_067875_0_0_1"/>
    <dbReference type="OrthoDB" id="2533647at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="245" mass="27765" checksum="65DA7988BFF69EBE" modified="2014-03-19" version="1">MTTPTEQVPLSGLPANTRPDKAIRNNGPLDLALERWCIVELAQGWPLYRDAREWDNFRSIFHPDGAYVYTTWTGKTHINDFIEASKASMEAGAFIMHRIHGTSVDLLGDRAICKMKATITQRFVLDGNIEVDAESDCRFCFFFQRYTAADGTPSWGAKLVRHWYEKDKLIPVDPRKVPELDDELLATFPSGYRYLGYCQEISMKGKSDSPLKVKRDMPGHRGAEHDALLRAAKTWLDGGLPDDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVT3</accession>
    <name>W3VVT3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVT3"/>
    <dbReference type="HOGENOM" id="CLU_425241_0_0_1"/>
    <dbReference type="OrthoDB" id="2556550at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="753" mass="79126" checksum="A6BF3DE96252B617" modified="2014-03-19" version="1">MQRPHSTWLLTTLTNATSPHLSALPLPQSQPSAIPTSGRRSHLGRPSVSEGNEAAAPTPGVGMSRNTGGAAPNWRMRGDGFDAGASDDDMGVEDSLRGPHRSMQPRLGRAHAPITRDVPDLPITPSSAGLLDAYAFAATPDAALPNDPRSMLAEPPRIQRPAQQAPTRGAGTFSQTSAFPPGPARAPSGLFAAPAPRPIPHGNLFARPPHTFGASLGHFDLDNSASASTSISGSFSFGPAAARVRPEGMPSIRPGPLLFNAGRPDAAVQTRQTSDAAFFAAPQTPVRPARATTAVAAATAMAQPPSPATLETAALAAERRTRQQRSARPDPIAAASTGAAAGDVPNRRVVSFSTTPAEAAMTPANMLAAPSRAPVPGAVPARAGAHARTMVPESSFSHLGRGPSRPMLLPGAAAGQRDVSMSLSDVSASVQGAATRLFPRAAPLPSASSGVFGSEPMPDSHQSWSQHPSTSISGPAPEPVEQVRLRRWDGAQTSVPAYLVADNAETAVEEQFDYDTIARFDVGQLVSRHDAAVAGEGEQQTTQEEDTDALHAILEIQLGLRGLHGWYGHTYRNPRRDAVPSGAGESGRTSRKRRRRDSDASDASSASDPSRHSASDVESDEDAPIVVYDTFGRVRGTVTLPNYTRRGGRGLPLPPPRETHAVRSASAAHTVRTNGAALGAKEAALVQQHELVRERYAQLQPDSNQTVRSAAFYKQMAARRAALAAFQKRLGQPLLVGLQNAYLDSAQVARLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVW1</accession>
    <name>W3VVW1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVW1"/>
    <dbReference type="HOGENOM" id="CLU_040940_2_2_1"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="297" mass="32804" checksum="FC7D244825DB1F19" modified="2014-03-19" version="1">MEVQTASNGECHEWLDLLSAHNAACIRRLIATPAAPSFQHVPTRKQAAVATLLYQDASSGELRVIMTTRALHLRSHPGQASLPGGKVDSSDADVVVTALRESVEEIALPSRSAMHLHTGYPFLSKLGLLVHPVVFLVRYPAEVLKRLRASPDEVSDIWSTPLRAFLSSTAPEGMELSDPRSVDKHRPPQEAFRTYTDVPWLGAVYRLHRFRSSHQLVKGLTADVLISVAHKTYGVEPRYAIRADGQMSWQSMVEMVVKRYMGPQRAEQRWGDGESGDAQGSSEAFPTHIGHDDLADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWY0</accession>
    <name>W3VWY0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">PaG_00341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWY0"/>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_1"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000131">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="181" mass="20684" checksum="F3D7E9D959267AE7" modified="2014-03-19" version="1">MPFPLPLNFPKWLAENEHLLQPPVGNYCLFRTRDYTVMAVGGPNARSDYHYQPTEEFFFQYKGDMLLKVINEDGKFEDINIREGEMFMLPANTPHSPVRFANTVGLVVERTRPEGSPDAMRWYCPNKQAHGDTPTLVREVKFQCTDLGTQLKPIIDSWVNDEAGRKCAECGYLQAARELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX46</accession>
    <name>W3VX46_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic ring-opening dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX46"/>
    <dbReference type="HOGENOM" id="CLU_046582_1_0_1"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834946" evidence="6">
        <location>
            <begin position="24"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="7">
        <location>
            <begin position="50"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="372" mass="41080" checksum="36B438D23287B32A" modified="2014-03-19" version="1">MAAPAARLALIILFSLLVALVSHRFVRRPSSFLNFNPISTMVTATKAPVFFISHGGPPTMFQPEHPAYQHWREWGKQVRELHQQGVIQGLVFISAHWQAENLDQGVYGRSSATAQSIPVNVDERNPLVYDFYGFPDHFYKQKVESSNPSNVSALVLEHLRQCGVQAFPVKRGIDHGVWCPLKVAFQKPFLEDLPSGNAESQSASINDPSQLPPTLSLTQLSLPASDSSLDSLKLGAALRRLRDQGFAIVGGGMSVHNLREAMKAFALVGRGFGALQPTSYSSSFLSALTEAMTAPRVSRDEEKWAKAINLDKRHDFLPSHPTPEHFLLRARPFLFLEPAALVALGAAHSDEQGVETFALDEGPMGWNMYRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX74</accession>
    <name>W3VX74_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX74"/>
    <dbReference type="HOGENOM" id="CLU_303669_0_0_1"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF89">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="919"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="980" mass="108097" checksum="4BA9F809413EC3FE" modified="2014-03-19" version="1">MHDASASASTNPAISMRRASASSPGSPSPSPQQPAPARRTKVSCFPCRTRKSKCDHARPCSSCVLRGTEQQCANPNGAAPSSAQPPSSGSGTSTPVHSAAKSRPLPSSASMPGLTDYATNQPINNANSLNSSHAKRRRTEAPPPPPGTAAGPSQSRTDPDQDIHQEVNHMKQALARLEDMLERRSRDLPQPGPTSSSSTASSPAVCDYKLDPIQDCPGEADPPSKESRQRWHRLRFLLPPLVDTHTIMYYLFVEGDWLMPWIEPPRFIARWRHAYERQAISDVLAIQVLCIVANAALLLSDNRQRIMQCPIPVRTLHVQLMKEAVSMADAMPALRDGRTEAESCDLLEIMLSISFYFRCIGKEALMGRYCERAVSHAVRIGYDNEFRPCWLGLTPYQVERRRLLMMEAILTTKWIAFHCRKELAHLRTRSFNLGRAHLEYVGQLPPLSAWPESDSLSLAIGAHARSSPSSSGAATAISHYLPWRPKTEEEREVVRTYVFVSWSFSHELTAIVDLISKTETRLLQPEALTRCTKEDMRDMARQTRQILARLNEWFHSSLPKVGLGFDQIVNSDANGADPIQAKRLATMIMVNHAYIYKTSILCRAWLLLSDRLQSLNDLHREDEHEHPATMDQHFFAQFTQRSIDHVQHMHAAWLPPTFLAEIEAAVLENARLCIRLIPVIRTLQSQPWSHFYISWVSQSSMQVAVNLAVPLVRSHHRQNLSLHTQRTKPGAGVMASRTDELRQDIVTIFEAVSQLSDKVMARRTARVLNGAMQFGGIEQPMSCADDDDDANDVWQSEENSGQMHKAAEGLALLSAASASDASARTPSDRYTSSSQGSPALATRAWESTGRDTIQARWEGQARGTTHSHSTPTYWHTVAPASHSAAASETSVPAPSAVSGIEGGVARQPMWWETRFPIDTKQPADGSTTATAGSSSFGNTAEAAGGGQTIMSDSQLLDELLNLDVSFWQFVVDGTGLTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX97</accession>
    <name>W3VX97_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX97"/>
    <dbReference type="HOGENOM" id="CLU_478319_0_0_1"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="3">
        <location>
            <begin position="410"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="278"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="486" mass="53875" checksum="BD219893D2786CDE" modified="2014-03-19" version="1">MSLQDKRKAVSGSSSAPGPSSSKRVRIDDTTRRTAKRHADTDYFDGDPEIEEQDRRRLRKDQKRGRIDDRGEDLSASDDSDDDADSDAGADAGSHRRRAERRRKASAKDGADDDDDDMFDVGSDDDAAPSKGKHKAAEKKRFLKLGELEEGQEFGSKKRSALDADADADLVRGDGEALDDDDDADPDLELEEDARSANGQDEAVDLNAYAERTPPTSPGGTVQARAKAPKVTGFNMSDEMRTGAFDAEGNYHEHARDPHAQHDAWLTGVYSRTTILDARRAQQARDRALREREATAAQQDGDEDDIKRRLVEHMQRTETVQRTLQRLGKQLAEQKKRGQRAEIDKAAHEVESVTHLASVLMSRFGRLDVYEQTYESLLHDVHKSGLVRNTFDPAAKFDPPTEALDATQTTAEWEYRWTPAYLAAAAREQGTCVDPEIQTFGPFSLADLHAWAEQGYFGDGGDRILVRRAGSRDAWIPYAELSAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VCT7</accession>
    <name>W3VCT7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VCT7"/>
    <dbReference type="HOGENOM" id="CLU_017661_0_1_1"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="432" mass="49092" checksum="DE6A22133B7236CA" modified="2014-03-19" version="1">MSRFIGLKSQPYPLDPTGPNASAWDTLSAPYPRYPNKDKLFAQLLPPAVYNATLSPWLPFSFSLAYYLVAHAANRIVKRNGSTDFTKGSTLLARTLRFLILVHNAALAIYSGWTWAMMFPYVVDFFVQGWSAAGLQGVKLALCSMPTNCPHLGKYAYIFYLSKYYEVFDSVILLLKGKKVSNLQSYHHAGAIICMWIAYRYQSQPVWVFCVFNSFVHTWMYTYYFFAAMRWPFPRAVKRNLTTMQIAQIASGTFLTNLYLITALNPDKVVAGFKANSVSSWFQQNPAKDESIFVHALLRAASSDPHTCMQTTGAEIALHVNTMYMFPLLALFFNFFMRSYIQKPKSAPSSQPVKSIPAKRSFLGAIILELKRLTQIPIMAGRTAYWRWEYSRSQHEKLAAARLLFANHHAYWGSWLVPGSYSGLATAIFFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDX2</accession>
    <name>W3VDX2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDX2"/>
    <dbReference type="HOGENOM" id="CLU_282564_0_0_1"/>
    <dbReference type="OrthoDB" id="3359121at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="5">
        <location>
            <begin position="600"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="786"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="664"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="857"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="928"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1105" mass="118730" checksum="2D429E239654872D" modified="2014-03-19" version="1">MPIARDAESVVGSVIGSDMGSDVDMGSASEVEPDDFDDDFVDLGGVLEDQEDNQHADALEADVSVPPHDPLDESEEEHDSDKENAPLPASQQSHRSQASPDPAHSLLPSRAVMDEDEDELPGPRINTRRGRRSALADDDAEGQADQSSLQPGPFEAIIHGEDVAAQATSSSDRARIPLADISSQIVDPSMVLSRSNTTSPVAQHAQLPTTIEAEERDPLIFSPTAGDDMDESFRTDDIPSQAADLGRFFESTMPSSTANKPNPLASQPPRKSFWDETQTQTQSQDQGARASQLSAAAGRPHANEVARVMARDPSGNSALEAFFNATQDEELRGESLDIFANPKTAQAEAHGLTALFNDGRPSPFGHSQASAEPPKLSAGARDASSMPPPKSTEVDAFAALRKAQMGAAMELLDPTPSALPSFDESQAERDAYAQLQRGGSSAHVSPEKMYMNRDGFFTQTTPSQRPGFWSQYDTQSQSQSQDPAASKGNRAITDAAWQRPVPSNSARRGSEGSLIGPKLGEKDVLEDEEEQDVPVQLKRLRRGGARVLQAAEEDADARDNADKRSGSSSGQPEGRPRDAFKILLGRTLPTEEDDTAIRDKKRKSAFIEGEAEESEDEDLGEQKRGDGGGLKGVFADENGSDSGKDEDEDDEEDEDAEDLQELVDNERDIDEAQKDEVARARFREDMEARDREDLEIHQKAIQGGYRNRRGRGAGLNSIEGFLDDDADEEELQRRAALGLHMSSSAWKKRKLLDGTQDGMDALAAHDEAKAFVHSYVATHKIEHESDKYDFLLPQPGDADAEAQDSDEDDDQDEARDGRVDEREDADDDEGDDEQKAELEDVDEDAFGPVVTKQPRKIRYDDVRAAIRERRKAKNRGALDDDENDDEGQRRHRDGRSGSDGSDSEEEDAGERLASALRSRVRGDGSGSGSAEVEGGADAAAPASRRPHLGMQYGRAKARGTVAAPAREEAECMDVDVQPVASAGVGEGDEEASGSLSLMARLLKRPAASARRAALASQSLSMSLDTLEEAEPEWGNEANLVRAPKATAGGASQASSSAMSAGKSALPLGPSANVARTGSRGAAPMLSSKQEIMRRGGGFVGSSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDZ7</accession>
    <name>W3VDZ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arsenite-resistance protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDZ7"/>
    <dbReference type="HOGENOM" id="CLU_343612_0_0_1"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERRATE/Ars2 N-terminal" evidence="6">
        <location>
            <begin position="336"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="SERRATE/Ars2 C-terminal" evidence="5">
        <location>
            <begin position="712"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="688"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="858"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="105935" checksum="3332719E088709E9" modified="2014-03-19" version="1">MESRSRPQPDLACIRTRDSLLKAEEAEGERRGEARRGERDRLLEGLEAQMPTSTLDSRPPPHPHPHPHHHHHHHPHRPRPDTFINNITSSIAIDSPSALHSPSTPTLRIGMDYRSSYRQYDRSAPASATDNHHAPPADEYKHNLDDSYDRSRKRGRSPSPPYYRDDRRASAYNDYHPSADPWDRTRDSRDYRDPEPYAPRPSAAAAAAYDHYRSADPYDDRADRSRAAEWDRYYRERDHRDHDHRPTYDDRERYEARSRYDDAPPATSADRDDRPRIRERERNYPSYDAHHRRDDHAPHSDLASNAPDPMQSDTLLPFRQYAQMIRAAHPSARDRSIDQPNTQEIYDGYQSYKAAFNKKAIATFFQQRKHEAWFMEKYSPLDPWLSARIERKKAARTGKKQAWLNELQQGKLDKLNYDIIGTDDDSASRRDDSYDGGDHHDSRGRAEPSDVTLLSRHGEPETLHAEQAIIPACSHQILVKTYPADVPREKLEEVLRTKPGFRYLALGEPHVGKRWHRVGWAMYEPDIDMDDTLNALQGKDVDGFALNLAPCSKPTSSKLRTVPEYANSFHRLLTDLRQCRQLVERFESEDRQVLFRDLLESDASAASWLETNASDAILERIKHTDPELVDDDLERGYDADEDATKREERRRLLKRQLDLHLDLLRTVYFCDYYISLCCEFEEELLRRSPRHARKQPPSGQLVEEAREGTNDESWARSVDQKTLLLLADERTDLTEAGGKSVDAELMAAALAYVKEEDKEKHRCTVDAGAGQCGKLFKAAIFVQKHILNKHRAFIEAQAQTTLEEVHFFNNYVRDPCRATTQLGVARGDGAPLAQRIDSSNGMYSSGGRMGMIRFGNASAADSPRRQPGAGAPALGMRLGGVVTPDVGTPIKAEPLPPAPKPLDPRAQRAAPKSYQDLDGAAEGDVDLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE24</accession>
    <name>W3VE24_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-methylcitrate dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE24"/>
    <dbReference type="HOGENOM" id="CLU_021803_1_1_1"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="282"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="552"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="81140" checksum="561A51F797692FF7" modified="2014-03-19" version="1">MSVEGWGPGRPSPNLCLSCSGWRLEGGLVTISVLAQSQSLPAQGDRPTSLPASWLTGSALPRALPRAPAQSQALAASSRKRLGTAARGSDAALLHCRAWPGILSSSAVHARASVALDVPLLLPRPAPPRPPAPPVAYLKVQHNFAGSSIPTTSFQPPSLHLQPISSSVYHIDRRIRRRIHVRVSTATERLRHALRSRMPRLVSQSTLAASLRSTSTRSISTSALPRATAVAARSVGQLANKSVLAQLPRSAAFSTSARAMGGHAGVGKGEDNVRPPPDQVLQDIADYVHNYKIDSQVAYDTARLCLLDSLGCAMEALRFPAAANVCGPVVPGTVVPNGARVIGTNYELDPIRAAFNNGALIRWLDFNDTWLAAEWGHPSDNIGSILSVADWISRTNIANGKKPLTVEDVLTAAIQAHEIQGCLALENSFNRVGLDHVVLVKVASAAVVSKMIGNTRDQTVDVVSQAFVDGQSLRTYRHAPNAGSRKSWAAGDACSRAVNLALLVQKGEQGYNSVLTAKTWGFYDVLFKGKEFKFQRPYGSYVMENVLFKLVPAEFHSQTAIEGAIVLHGRMQKNGKTSDDIKHVTIKTQEAAVRIISKSGKLNNYADRDHSLQYITAMGLINGKLDPEDYSDEVAKNPKIDELRAKMSVEEEARYTTEYLDPELRSIGNSVEVTFNDGTTDSIALDYPVGHARRRDEAKPLIKAKLQKHLKGFFPEARQSEIVALLEDHAKLTKLPANEFVDLWVRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE41</accession>
    <name>W3VE41_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE41"/>
    <dbReference type="HOGENOM" id="CLU_302294_0_0_1"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="987" mass="103778" checksum="2FCC1B2EE2AA2035" modified="2014-03-19" version="1">MDGGGASAAGGGFSGGSHDHGHHGHHQGNDHSHHHSHQHSHPAPAPIPASVDPTPQFPPPQQAPRTAVRMAATGSAAGSRAAPAQGGEEAQWSLKDIYWRGRECKIITQNQNGPCSLIALCNILLLRGELTITPPDRPVVSYSYLSQLIAEHLLSKPLEGAAQGELEAALSTLPRTQYGLDVDVGFDSISEFAAAAGDGRQGGAGELALFRLCGVPLVHGWLPDPADSTTYEAVKKAGSYNRATDIVVRGNEVAEGAVVRDRGVGTLAASLASETSVANGKRPERRGWTGEHHAIVRQALALQTFLDNTSTQLTYNGLFVLAQEVAAGEPVALFRNSHLSVLYKRLPNEGLDAADGSGAQTPAPPTLFTLATDSSFLLEDEIVWESLVDVDGASSEFYDGKFRKSTMRQGDYVGRDADGLGGAGGLGGEGLHANEDADYALAMQIYQNDQDRLVRQQQRRSGRQSQGGYSSRSRPSQQQPAAGMGMGLAAAPAPAFETPREVFTTMRYETEPQQGEVADALVAASLIPAGLRAEHQSLLDAMQSLSVGGGGGGQSVDSAAAPAPAPAPSTNPFLNASESQTNAIPTTTNPFLRDSATEAAAPTVGTSAARHRLFRHIPLLAQHLERLVSSAGAMCRVYSAVWSMAALEQQGSLQPDRILQAIESSLASSAAQDGEGAVKGVRVAIGRDGSIRVTQRTISAFPSMLDSGSNAARPPSVRLDAAPTRVRTMDLEPLVFNKTDARGFYEAAKQRVGADPSVLSGIREGDQRCFDVILWNDEQMDTLDQADAAIPSAPKRLVTESSLANVVVELTGGGAGGSRFITPRTSAGMLDGLLRRWLVDKGVVDEEDIEVDELVRWVRQGTAQLWLCNSLRGLWKVELVEGPLSAVPAGAVGSAGAAGTGMGSGAAASNEGKKNRFSKLMKGPSRPTNASAPTGPGASSLEARQSDAVHDQVIDDLYGHRQGGASQSKLKGRKGNKSKDDKNCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE98</accession>
    <name>W3VE98_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase III subunit RPC6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE98"/>
    <dbReference type="HOGENOM" id="CLU_033661_3_0_1"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="56631" checksum="FFA2E8BBBE2FE57F" modified="2014-03-19" version="1">MPRASSSSASVGGSKLTKLESALYRAAQSARGGVITQDQITDQFKHEQLHDQLEAINGLLKKSLFTVQTLNGSIQYAATAKAEASMMGKLDETENMVYQHIKDSRNEGIWTKQLKARSGLHQTIINRCLKSLEQKQLVKAVKSVKYPTRKIYMLYGLTPSIELSGGPWYTDNELDTGFINELSMACLNFIRSKSFPKNGQSRALFPTTHTSQLPSANTVHTYLRSSGLTETELELEHVVSLLDILVYDEQIEKIPVLPFAFGGGARTNGFDDDDDDFTDSGTSSGGSGSDSDSESGSDSESEAQETGSDSEAPRKKVKKERKGHDESGSDDEDDAPVSSRKRKRSSGKSSSRKKSKSSSKRSSKSKDKKSRSRSRSRSRSRSRSRSRSRSHAASDSSDASGSESDASSASSASSGRRRSSKKRNGKSAARSGGGGDFVPFVYRAVRPHAVKVGWTETPCGHCPVFEFCDDSGPVNAESCQYYGGKHDELGRKLTNGWIDTVADGDDEDDAEDADKDDGALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEY9</accession>
    <name>W3VEY9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEY9"/>
    <dbReference type="HOGENOM" id="CLU_331532_0_0_1"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="864" mass="94174" checksum="60FEB8D3E2A2370E" modified="2014-03-19" version="1">MQAFSPSPRRFRLWTAVLAVAGSLLFTSVFGTALPVRSAGTCVPGHPCFPSEASLDEFNRTVHGRLRSERPIASVCYPSDSSFNTTECAVRNSSATSFTYRTGHFASLVYNNWEQCDTQACSFPLSSTLLDPSGPLSAAPCEQASVPSYSVHARTEEDVQSYVSFATRHNLRIVIKNTGHDLLGRSAGKGGFALWTHELRKKVYHTNFKLSNCSHSLQHAVKADSDVLLQADVPRMSFSGAITLGAGVQWADAYKFASEHRRHIVGGASTTVGAAGGYLQGGGHSYLTPSYGLAVDNLLEARIVTSDGRLYIANEVSNPDLFWALRGGGGATWGVVTSVTYKTRPQTTIYQLSFSTPANVSEATFNQTMQRYIRLSPKVAEIGVGGAATFSPTSLSFNLVVPNTSTSFSSFKAFTRPLLTFLHDKDGLDMGGKQLDELYTIWPNHYDFYIASNGGDASDSGAGTSGGGGVTSRVLPRTAFTDGDQSSQLAQLFLDSFAQARQSNTAFFQVIGLATPINTPYRNQTSLNPGWYRSLWHVINLGDMADKLREMTPDAAVYLGESSVSEPDYRSGYWGRENYKALQDIKQRWDPANHFAVFHGTTENAALFQACGMNVAYERSNHCDNGQAFPSVEYCKLMARINPDIEPDVFPILRSIDGGVTWTNYSSIRDTQNGRDMRFQPNPHVPGHDFAGYAAGPSWLRVYRRPLASKALSGSTCMRARTEKISYATSKDLKKCNCPAHYRISSDPLNFQNAPDYALQPYGANNSPVNSGPYIIYYKAPGATSGTLIATTAYDANVFLNNDSASPTTWKAVNIGQFPGYSLNLLILNDNGTNKLHVITGGYYGCQGSYHNYVANGVNDIPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF94</accession>
    <name>W3VF94_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF94"/>
    <dbReference type="HOGENOM" id="CLU_1750482_0_0_1"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="149" mass="16333" checksum="E391054E27CA9FB4" modified="2014-03-19" version="1">MSAAALIQEQELQLRAQSYYPENVAHNSKQVEYVRSTALSVAGSVAGVLGMTNWLGFGFYAISVLVTNVLVLVVNANRTPSKYFITPSPPSKPLSTTTKGKTGEVKIDPRSGSFTTQDTAAFLVSGLTENAFSFILWWTFWYGIVHVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFX2</accession>
    <name>W3VFX2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFX2"/>
    <dbReference type="HOGENOM" id="CLU_348576_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="818" mass="89404" checksum="9653C0EFF1F7D6CF" modified="2014-03-19" version="1">MSEPKPTQKGSVLSNLDASADAPPPPTTPPNPRSVSPEDKMTLSDSKETIDALASSKDAEPEAKKRKRSQRACIRCRGQKLKCDGVFPCARCLKLKLVCKEPSETNAGTPSSNRVNSDDRDAKAHTASYTSSIAAHPHSHPNSQLTPSGIPSHGPALPPYASSRPDGATSDRSRFLSHSHLGPQHREAMSHHPSDRFGYSLPDAVRRIDLLERTVSRLVERVEGHPAPLDRSNHYNPGRPTSSRSAASPHKPERKRARADSPDDSDAEVDELQDGASEASVPLQSLSHHQRRTSREELNGEAEHSAPPRSSHGVAASQPHASAPVQHDSAWSNSNGARRTPICDPIDAGFITIELGQVLLEFFLTYCHVFAPFLELDEKVSVSSLAATEPFLLSVLLAIGSLYHDSHGKNSPTVRSETHTGLASYALSQMGSQVCSSEPTIGSVQAILLIAYWPQAFPGCPDEKSLSGHASNLLQSVARRTQISTINGERTPPSHPHRLSSVWTCSRAFEALAAIDTGKGMDLSDHDLALSKAPRPSRSSIPTPYLVRVLPIVKELQVWLGEVSSNSPLAALEAAPPAPRPNLTHDWDRFKYLQSQLFDVEKRWLSAETDCSRLERIVGLVDRWTLQIYLASIALRSAEMGRPSKAHASERGAAYDMRYDEESARFVAAYRHEIRQACQVLLDIFTDPEISGALLYAPDYLLRRFGYAATAAAVLVDYHDAELTRSTQELIYLCSKRFEQISQLDSSTFASNLAWFVKSSYEKIGGQTNRDEHDSGMASAAHASVTVADRRRWLGGDVFSIFFGVGVLLDATIGQVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFY1</accession>
    <name>W3VFY1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFY1"/>
    <dbReference type="HOGENOM" id="CLU_295129_0_0_1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000728">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="960"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="556"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="722"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="808"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1003"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1026" mass="107052" checksum="1478CA9C82415DEA" modified="2014-03-19" version="1">MGHAQSRQQQDQARRERARMGRAAASARTLPSSDGQDHVPDAVAAVADDDASSGRKRRRSSTSPAPATGPNTVNEPLRQRRRRSADAPDSSSASSSADVASQPAASAPADEPMHLESQQPRSPLLPTTATEPSEPLADANTASLTDTSVPVALTREPSSTEDAPTPDAGAEPSNATPPPHLDALRQERERARQRILEALGSRAPIPSPASISAPIQPATTTSTTASATTPSPRPHPLASATLAALLGTMAAAHPATGEASSLPAAAAPILAAAANPSQSSNAQPSQPQQPTRPHTIRVPLQPEMISGTSMVVQGALVARTVASRPASSEASTGDDANASTASDAPRVSESASSSRTEAPRDSNNPIGLPPGALDGDGLRGAVTLEEQAVMLSRILGIAAAATAASLLNASESHHVDPSLLQTSLRRPFERLSQASTDRNERWLADWQRSRTLDRPSSLSGGGTASSSSSNASSLGNGLRGRLAALSRRVYSASSTSGLPPPTSGSESVASQPASSSNDPTEAPGAQSSGEHVDAGRDSSQDSRQQEIIAHLLDAAEREASSQRQRTDSVASSAQDSAVPPQSPSRGSLSRLVRSTLGTFMHPSRLLSTRHSRSEGSQTNDSTSDRDGGSSTSSSNATEAPTADFSLGPNDVVGTLRQVRNGVLPDGVPGSFGSFLNHLVRDLMAAVQLMRPSEEAALGQAEAHTTDYFEHATQAQTTSGAEVLDGETSEPATADAAAASIESTQGQQDQQADDDVGAAETQARRDRDFQNGNLSFFRLFRFDPVAPSQLVPCIVVGVRSLNVTERFGEEMMGSRAPGPGRDAGGTRQQTSRPTTMGSTRTTEASPRARAQSEGAPATAPARDDSTDASGEELPASRFMLFVSGGRYPANHPLLTSNPATAGRDLMILMDLLSTMQAMQNKPSTVTQQEIDGAPDLSKIRGSEVAALVGEGKITENMAERCLVCLEDWKQGDECRVLACRHAFHTTCVDRWMTTSSNTCPMCRRQGVTKDGRRAGDETADSQRAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFY2</accession>
    <name>W3VFY2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_239004_0_0_1"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="944"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1568"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1720"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1817"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
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        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="621"/>
            <end position="636"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="698"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1228"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1273"/>
        </location>
    </feature>
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        <location>
            <begin position="1284"/>
            <end position="1296"/>
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    </feature>
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        <location>
            <begin position="1462"/>
            <end position="1476"/>
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        <location>
            <begin position="1568"/>
            <end position="1588"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1618"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1649"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1918" mass="202571" checksum="C3A6DB0BD20A1ACB" modified="2014-03-19" version="1">MCALPTAGCSETGGAKPMPALKSCFRAAPLGVDRGAAVHTLASPEHLALRQTVRGPQTLPGIGDPTPGLLSLFTLHRPRQLSTSLPLGAAAMSGLGIDFGHESEAYSTDTGSRTSAATTSTSGFHSRTRAHMIPKKSSMNKMRGARPKTAEEDARRVRIVSGEPDILGHGAYTDEDFMSPPAHHDVVVQPHSLHSLSAAVAAMGGYSTDTATSSTETDSDTSPTLTESSVTSTSSGASSANQLNVRRKHLSQPPPGVHRHDDERGIRIMGAAQGASTAQQQPMPVVQRPVRESKSNTSLASGYRSDGGSSLGRTAEIPRGVGRNGGRGGHRASIRSAASRQGTLQNRLGPKVGANTAIEDADQTIRAEVPSDDETEVMVPDGFGGHTRTKQPRNPRPQTANAAVPSLLHRIDMSSDHAPSPNGQSRAEQYEVESSTRWKVGSFYAPDGSETARIDHETGTISEKGTQLEPSEVALSRAQSRGGSESSATSLTRSHTSSIGPKASLMQSPSAQNAARSQEDATEPSTEDGPVEGSTKAAAMLQNKQSRTSLASVAMRSKRGLQGLEEAERGGALVSLDNYRMTYDTGLPILPHEIHALDQDSIMGSVRLGQAPPMKTSLSHSGAPPTATASSASNASETDHAASSASSKPRNRPRRSLSETNVNTALLERHGTLLSNTANPMRRSKELNRLLGNSDRKLPSSAARPMHLESPTKSGLKRSNAMPATVVPPPAALEQGKANKARVEVDLVLESDLVVEGGTLQGRMQIRVRKGSDKEGGVLLAQPKIRVVGFEELLSDDTRYIFYHHASVIDGDRSNNGPSEPYYLDGSPTLSSPETAPFSALSCFSGSPDAEGYAEGKVGSHSIPFSLELPVSKGAKGSYRGKNAVVRYIVIGSVKLKSASGANRSIAHFYRHVDLFPYLNPAVVLSSANKPIQASSSKGLFLGGSGKVHLMASLHRNTWVAGQRVYIHIGIQNDTSKKINGMTLALIRTVTLYKPRPELDLDGQAARRDLDPDACQTSTTRKKIAEEELEMGQKGSRGVVTARGWWTGVEPGQRVESSHYMHIPADALSISRGRHVEVVYSIKVSIGSSLSADVSVELPLRVINFVSLDPPPSKKAGAAKFSVDSARSWVSPGSSAGDVRSPGSSSGRSTRDGAEDMVARLKSVDAMRSPGKTEISLANYDQHLQVARMLSPGEVAAEQKKLLQHQKSLDFINHAIRSAAARRGVDVTPTTSSSARTPSPAGLGIGVLDSSSASSARSRDSPGGSSSTDGVSGADEDYEEDNTKTPMASVNRSGTAQPIYPPGCEPYEPHHHRAHQAQYGGAYSQLPVTLHLPGGMHHMQQMQMQMYQMAPPPHAGVMLPVLRINNANAVSLDEIGDDYDDDVQDARVDPDQTLGLNDESMAEMNMVIGSARLDDEDHAQFDDSMHVDDAEHDERQDMLFERVSRAADAGNEGWSLRRRDSADDEPEAHDADEADDVAEVSSIMQAVSLEPAAPPSSEVSVPGSMAPPTAAAVTTSVYDASQAAARRAVASPPVPVRGQSRATVTISPRTNAYAVSNVTRPLKISKDSSATSSLLPQQTIHAKASSEQLAERSAGEVAAPSRDTQTLSAANLKRHSDNLSYRQQQQQPTRHRATHSVTGLKPLILKPKATSDGRRDRTSSAGSRTPDVASPREGAFVSGTGVAENVRTPDSLSSELSQIAPAPATAAKAIETKPSLMHKASDASIASTSSPAAHSAGLPRSSTLQSMPMQTEGRMSVQRSESMSSVVDDAGDDRALSRSHSTHNLRGAAVLVPSVRNKIAMLESRSAALREFTGAAAEASPASSPLKKSTSTSNFGLSSSTSTGRVAQLAASAERAGSLTPSASSPFRLGRKGSFVSVADSEDGAGSMVSSVAPVPEYMKTAASSVPSFNAPVLRNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG11</accession>
    <name>W3VG11_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_05456</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG11"/>
    <dbReference type="HOGENOM" id="CLU_001485_33_2_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="76"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS60598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1164" mass="126244" checksum="2955E346FC9A13B0" modified="2014-03-19" version="1">MASSSSNLRRQPSSSNLTRPVQPRSRAPSVAPPVASSAAARRLTGNAAANHPPSRSASAASNDDAARKRSDAGESNIQVVVRVRGHAPNEPPRTAPSILTTSGPRCQQIDVAIEPAPVSSSSSSSTTLQQESSTRQKSYHFDQVFGPEADQGMLYQDVVGPILEEVMSGYNCTVFAYGQTGTGKTHTMEGDLTSQMGTYSSEAGIIPRSLYRLFHTLELSKEDYSVKATFIELYNEELRDLLSLDNASSANDAAQHSSLRMYDDARGKGVVIQGLEEVALKDAAHGLAVLRRGSHKRQIAATNCNEQSSRSHSVFTMTVFIKDKGSRGEDVLKIGKLNLVDLAGSENIGRSGAENKRAREAGMINQSLLTLGRVINALVEKNSHIPYRESKLTRLLQESLGGRTKTCIIATVSQERANIEETLSTLDYALRAKSIKNRPELNTRMTRSALIKEYVFEIERLKGDLQASRDQNGIYLTDDSWKTMHAEHEERKTLTDALKRSAEVTESKLNSLKEQFEQNMQLLVKRDNEVRIAKAECADRVAELEALIAKAASLELTVDEEVALRKAYMASEAQLNTAASSLAELVHKSTADVQGLFDKLERKTAVEKANRTLVAECRKAVSQRASQLESSLSAFHAVESQFSTSLKTSLRDMVSATESHHDEHHQWLQARLKKISTSLREVRSGQLESKDVLASLLGDLDATVSALQTSSETSLGSLKQTCRGAIDDVVLANTQRFTHVAASFEQVVQAHVATLQEVQETNQQNRDHIAHVKAAAEAASREEMQRLRDQNALLAATVDEMKRSNASLKSEFMVEFGGLLDRLTDKQESSVAASMASAQALVARSTNASESHEASQRARFDTLSAATGEIASKLERSQATLVEETRTIATDVSHASTELGTKMDALASAIEDDLSAWSSAASRGHGEISSLAEKAKEEVEARAKAQSSKIKATNTKLTETLEAASAHLATSSQTVTSAASRVMDMVGAHEGEVNAWGEAVDVGLKELKSESDTMLVSKFREDRSTGQTPQKRVWKMPGRWNLVPSNRQEAIEAGRKVADTLVSEPATSDVPTSELDVEDGAEVEPRLEAEVEGPAATPVVEDVEDGGAPRRSSRPLRELPFGHANVPSSTSMEELAIKPTIAASRSAKNKLTASALPTSKRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG78</accession>
    <name>W3VG78_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05378</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG78"/>
    <dbReference type="HOGENOM" id="CLU_091071_2_0_1"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="153" mass="16893" checksum="1131DD5A393E5DAB" modified="2014-03-19" version="1">MLFAARRLVARAPAALRVAPTPVTAAPRLFTSSALRFAAGPPVIQGEGGKDGEMPTDEQQATGLERFELLGKLQGQEVFDMEPLQMTHLGTTENPIQIKSYWPTRIVGCTGYPADSHDTIYLHLNRDLKHHRCPECGSVYQMDFEGDEHAGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG94</accession>
    <name>W3VG94_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_06253</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG94"/>
    <dbReference type="HOGENOM" id="CLU_008438_2_1_1"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="376"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="461"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="531"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="938"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="939"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="958"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS59731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="981" mass="108715" checksum="B12A477E78DBFAF5" modified="2014-03-19" version="1">MASLGQTAGSMRSRQQHAAAEQQQSPPPMPPPPHSEKPSLYTSGTQLGSANDSTPIKSGKLYSNHANMHTTGLGLGIGAQPGASAAATNVVSAKEHRILAALVILALFVRMYRLGQPSSVVFDEVHFGGFASKYIHGRFFMDVHPPLAKLLITLAAWLGGFNGDFDFKDIGREYLHGNDTPVPYVMMRGLNALLGVATVPLAYLTLRGLSLRASTATLGALFVLFDNALTAQSRLILLDSILVFFTALTIYFWVAFCNEEKRAPFSLRWWSLLSLTGLSLGAVASSKWVGLFTIATIGISVIAQLWEHLGNVRQPVRVVARHFCARAICLIGLPILVYLFTFAIHLGLLHRSGEGDPFMSSAFQHTLHGHGMADTFADVALGSTVAIKHLNTQGGYLHSHTAVYPAGSQQQQITLYPHSDDNNNWLIVKAPGPEDPAPKLDDKGHPLRPEDEVSRFHQEPIRYLTHGMEIRLIHNATDKRLHSHDTNRPPVTESDYQNEVTAYGFEGFGGDANDNFHVEIVQGDKRDRHSSTRVRALRTHFRLRHTLTGCYLFSHKVTLPDWGFGQQEVTCNKNPTMPNSLWYVETNTHPLLEHPKDANAHIDRVNYRRPSFLERFWELQNVMWETNAGLTDRHAYDSRPQTWPLLKRGINFWTKDHRQIYLIGNPFVWFGAFASVLAYLGARGLLMLRAQRGFGDLKDSRVRFYDQTCGFLVLGWALHYLPFFLMHRQLFLHHYLPALYFSILVAAVVLDFATSTLRPRFRLIASVVVTVVVLAGFLRYTPLTYGSDWTLQACEKARWRKGWDFNCAQFPRDLAEFKNFPPSVQTLEWAQGKDAAHAELVDASANTTQEVGAGVAEPGRHAFDHVPLRAMQSSAAEAYQHLKDGLQHEVEYVKGKVGLGAPGEHDPVAAGKAADPAGLDQQQIEQVMLEGTAPVVKDAAAASSAAPHEPSSAAQLDAHADQEAHEAADVVQADREMPLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGB6</accession>
    <name>W3VGB6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pectin lyase</fullName>
            <ecNumber evidence="7">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05474</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGB6"/>
    <dbReference type="HOGENOM" id="CLU_345164_0_0_1"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF67">
        <property type="entry name" value="PECTIN LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832953" description="pectin lyase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="11">
        <location>
            <begin position="388"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="699"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="742"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="789"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="832" mass="88102" checksum="CA77DEA288905299" modified="2014-03-19" version="1">MRAGLGHGLVLLLACVSAVCALDTVTLDLNKVTPIDMDSVLPRYYKPDTDQVCFNNGLRSSFCHFDDGTLVNLTSTQRHHLRKTLRQHGITRTVDVMSSSAHQIVDPSKAAVTSDEAVCFTSFLKSRDWSRNATNTVLNELYVRHIIGSHSERAWKIVSPTGCSEDIQRAARAPLEQPNAFADMTVWHPLMKNHNSDPWAAFRAGTDGIIKRSLARVHLPHRHARRASKDKRHASRPQGYGAGAPAFPGFPVFPGFPQQGVPGMPGFPPQGAPGAPGAPPQGAPGVPAQGAQGAGTDAGAGAGSDAGADVGAGAGISAGAGASATSAQERSASSSAITSKPHGFASSVTGGGNATPVIPKDIHELERLLADAQPRVIHLDKTYDYRGSMGVCTNCKGCIPDSYPKCPSKGQLAIDNGQGWCAGKPPHAVTYDKAGLTPLSVGSNKSIVGLSANAGIRGRGLLIAHSKNVIIHNLRIDQINAQFIWGGDAIDLRDTDLIWIDKVTFSLVGRQFIVTDYVGAGRVTISNCLFDGQTKWSATCDDSHYWTVLGYGKTDKVTFSGNMMHHCSGRSPRLANPQDKAGDSVWHVVNNLFDYNTGHSFDIGPGVSVLIEGNVFNDVAQTSLHESNPGRAFAPSDTSIGAQCDRVLGRNCQPNAYTNAKPIPSTTGLGEVLKDIALETLTAAMPPGDVLALVQKNAGSGSGSAANLSRGSADAVHSASTDNGAKPEGYGDVPTQPDSQQANAGTPANAADANAAKPKSQQDKNKQDKKKQAADKKKHDQQAKQLADQQKKQQAEQQKKQQQKQQKEQQEQQKKAAEAARKQAQGDAPQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGS1</accession>
    <name>W3VGS1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04764</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGS1"/>
    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="182" mass="21324" checksum="F8D75B3FCE5B8B71" modified="2014-03-19" version="1">MRQLKFHEQKLLKKHDFLAWKQDAGMREVKVMRRYHIQDRDDYHKYNKLVGKLRHLALRLSTLPVADPFRGKHEQGMLAKLYDMGLLDTGAKMSDITNKLNVSAFCRRRLPVVMVRLKMSETVGQAVKYVEQGHVRVGPDTITDPAFMVTRNMEDFVTWVDTSKIKRTIAKYNDELDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGY3</accession>
    <name>W3VGY3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_05981</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002476_0_0_1"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000099">
        <property type="entry name" value="Sensory box sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAC" evidence="18">
        <location>
            <begin position="1023"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1110"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="1375"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="263"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="936"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1336"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1529"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1583"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="981"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1355"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1583"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS59991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1741" mass="189707" checksum="06A9578155EB9531" modified="2014-03-19" version="1">MAAHETDQPSSVAEKVWPGKAVADLPGAAVSMVASATSQTSEVFRLPPSHHHPRAPPSPRTDPASKPTSITAHLTTHRPLGQSHLHRTHFPTLDDARCQFELHSANGIPAHRPARYHLAEPAFPTQLCTISEPFSDPIECTALHCTALHRTAPPVPLADYCDPLHAAPLVDSRASPAPAPSALAALLAGSAKLTWLQAYPLCILSSPPRPNANSYTLSSPCRAALPSGGHPFRPTPSAASVLRKSFVFLLAPRRLAAFSSGIHLPHSTLDDTPPPPSRKRPVTEADVDTSPLSLPDKESSSTFPAALAAASSSVQKRARFESPGGGPAPATNNTSLPINTESFPPHYTPLPPTKATNPRAAHPVRSNSTFGSFHSSASGTSNSNPNSPSNASSNPISRRSHASTLDPRSPPAPLVPFPAGSSSYFADSSARMFDLDESVRALYFAPTPIVVLDHNRRIRMMNRPCESIFLMTGVSCMGQTMDRLIIEKHRADFTTALNEAAQVRATAAWAPPVLTRLTFLQDDQKMFSADMNISAWHPTDEVFSETFNNHFARSLSGDAEKSVDLDNEPSPGTPQRMDSMETRASTLPHESYFTISIVPTRLAERRMSPADLETTKAEELKEGVFHTIETAIMALSADGSTVVRNRACDELLQMFQKKNPQDKPKKDNAPKKPTKDGLEVDLSWLSDVMDCYTEDFSEPFPEQNWPIYRAAILGQLTKPVRIGCVATDTGARRVYEIVAKPVRGAGGFGEHVGGVITLIDVTDTDKQRKLEVEQKGEEYFRTICDSMPQLLWTAYADGHHDWYNEGWYRYTGLNRQDSSGVGWQQVFHEDDMVETNKRWSHSLRTGEPYQTMYRCRKYDGSWKWMLGRALPLRDQNTGKIIKWYGSCTDCDNEVKALEASRKSQAQLTSVINHAHVTIWAIDRDAIITIAEGPGVRSLRLAPGTPNGSDGDGSGSGNSMSGSIPGGGAVHARSEDMKDAESQTNSQSAVSGQGKRSNQRSMIGRSIFEVWDSPGIREAISRALNGESVVQEMEIEGRWFRTQYTPQREESYEHDANEGPIIGVVGASVDITDRRRAELKLEESMHERSRALAAETAAKEASRIKSEFLANMSHEIRTPIAGVIGLSELLCDTQLTKEQRDFAENIQRSADALLTVINDILDFEKLELGKMDLEKTAFNLNVVIMDTQKMLTFATQKKGLEFRNECQLNYTGQITGDAGRLRQVLTNLLTNAIKFTATGAITLRVIETYEDPKSLHVHFEVRDTGCGISQTTLKKLFQPFSQADPSFARRFGGTGLGLSICKNLVDLMGGTIGLESVENKGSNAWFSIPFEKVHSIEAGGDSSPDEEGVSEMQMDEATSSLGVSENPLQRPRKDIWILVAEDNLINAQIALKTLKKMGFSCKVAKDGLEAVEEVGKQPYDLILMDCHMPNCDGYEATKRLRKSESVDIRTTPIIAMTASAIRGDREKCLAAGMSDYLSKPVKSAALESTLVKWLFDPSTRQSLSKYVAPPVQGDYFGAKKPGSGVLEVMIPKAGQPGSPPQLIERDSTETVMGPRSIQSGRRGSFNPIAEREAIASEIAASPSPVLASAPHPLRSSGAERSGSASLDALASEASMPASRNESDDEPIESMVAGPTLSKTSKRRLLRHGPVKVVCNDPMPTKFKPAPKTLSAPEVALADKPPIFIRRSSREQGGLGRDLEGEVVRAMEDGQDGPSLGVSMEESLEDVHAEVSQEEAGNIHVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH23</accession>
    <name>W3VH23_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH23"/>
    <dbReference type="HOGENOM" id="CLU_1288744_0_0_1"/>
    <dbReference type="OrthoDB" id="2549016at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834491" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="199" mass="21607" checksum="3F595360E9379FF3" modified="2014-03-19" version="1">MNLIFVLFFLLVAGAMGQMGAYRQMYSSALAPVQAYVASPHVIAPVSPPWPLNNPTAAMQRYLGALSNHDGYISPDAGAHLQSVRNNVRTVVEHANSPNARAYQRGLLAVLEEAGNTAKWEMQTALHPDNVRAQHKTALSALSAKITNLLNAVEADTQRLVSQLSEAESERFLLAHELLRAEKQLLNAASRLATSTPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH53</accession>
    <name>W3VH53_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH53"/>
    <dbReference type="HOGENOM" id="CLU_025025_0_1_1"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="408" mass="45575" checksum="AA403122D38771C3" modified="2014-03-19" version="1">MAIFKRNARATDAGDAVRNGSTNDADSDASSAKGLRKFAQRKPANTAFKQQRLKAWQPILTPRTVLPTFFLVALIFAPIGAVLYYFAEQVNEFTLDYTQCSTAPATPTQAQIPSSKYDYQLHDKNTSNFQPPTWSWDAGSKTCNLYFSVPSRLDSSVFLYYKLTNYYQNHRRYVKSIDSNQLKGDAVAYGTIKGGTCKPVDIDPATNKIYYPCGLIANSVFNDTFSDPVLLNVAGSDSANQTYVMSEKNIVWPGEKDKYKKTKYAADQIVPPPFWQGATGEFGFPNGYSDGQIFDPSENEHFMVWMRVAGLPTFRKLYKRNDTAAMEPGRYLLQVVDNYPVSMFDGTKSVVFSTSSWVGGRNPFLGLSFIAVAALSVLLGLIFTARHLIKPRKLGDMSYLSWNQPDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH96</accession>
    <name>W3VH96_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_06091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH96"/>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="467" mass="50367" checksum="7D64AB6666202479" modified="2014-03-19" version="1">MAPTATAGVAAAATAAAAAVPATLKTAVKAVQSAASTSANTLSTEETIHKEAEYGAHNYHPLPVVFDRAQGAHVWDPEGRQYLDFLSAYSAVNQGHCHPDIVGALVAQAQKLTLSSRAFYNSAFAPFAEKVTKTFGYEMVLPMNTGAEAVETALKLARKWGYMKKGIPEGKARLLSVAGNFHGRTLGVISMSTDPESRTGFGPFLDRVGPGVDDMHIRYDNADDLEKVLDKYGHEVAAFLVEPIQGEAGIVVPSDGYLKRVEQLCRKHNVLFICDEIQTGLGRTGKMLCHQHDGVRPDIVTLGKALSGGVYPVSAVLADREVMLCIKPGEHGSTYGGNPLGCAVASAAIDVLVNEKLSERAEELGEKFRQQLMQIDHPLLASVRGRGLLNAIVIDETKSTKGRSAWQLCLLLKHLGLLAKPTHVNIIRLAPPLVIDEKDLERGVELIRKALQQLDELDHIPGDDEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHB1</accession>
    <name>W3VHB1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PaG_06109</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHB1"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="84"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="584"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="644"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ETS60111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="685" mass="74286" checksum="1D78415EB895AA60" modified="2014-03-19" version="1">MNPHHPAPIAAAGVASTSEAPSTQPHGYYYDNLDDPYAGAFWSHFRQPHELAARHVPLDASPAATMKAYREYRDRVRKPVLATYTILGFLSSGTYGRVYKARLRTDPQLPPTSGSAAAGLATPTASGAANVATAAAKKRGGLLQQHQLLDSPSAASSLHPTPKSVIDLTAPANATPGRTRTDSPGVGAAAAATTTHTTTTNGGAAISRTADNSSATTALGGGDGQIFAIKKFKPDTKETDATVYTGISQSAMREISLNRELSHVNIVTLRQVMLEDKAIYMVFEYAEHDLLQIIHYHSTALRTPIPTAVLKSLMWQLVNGVAYLHANWILHRDLKPANILVTSNGVVKIGDLGLARLYSSPLQSLYNGDKVVVTIWYRAPELLLGARHYTTAIDMWSVGCIWGELLALRPMFKGEEAKMDPKTKAAPFQTDQLKRIVEVLGTPNKERWPAIESMPDYKGWWPHLRLDNYPKTLSRWYTSRHKSEDGYDLFDDLLQYDPEQRLTANQALAHGWFAHEPQVTLNAFASLAKPVGTYPNRRVIHDDLDPKMKSNYQPPIDAHHLPAIQQANLNSAHPIRLAQLLHRQHHLSQQGSGGEAGKASVGSTGPAAPPALGTVGMQTSAPSTAPSLQPNPPLITIAHPPSSTPTVRSTHSLQSGTDDSPAANSARSTLVATAARNNQRKRQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHM9</accession>
    <name>W3VHM9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHM9"/>
    <dbReference type="HOGENOM" id="CLU_005138_1_0_1"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="635"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="725"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112049" checksum="C604938132938D1F" modified="2014-03-19" version="1">MAPHKRSNSASSNPATPTKKLKAPHQSALTSFFISPSAASKPKLAAEPTSPISETARGKQRAQVGDVVLAATSQEEKDAQFAAELAAQDAGVSVEDHRARMRADEDMARRLHLEWSGDPAPSDGAAAGASKFEPASHAMDASAPPSPSKKPPSAAKPVDLVALDAAIEAIPLGDDIFVYDPSAVDTSAWPHVAGKHGELVPTTPYALLTHAFVLISATRSRLAITTLLTNLLRTVRAHDPDSLLPTVYLVSNHIAPPYDGVELGLGGSIVNKAIKSVTGKSARFLKQVWDKTGDPGDVAYEAKKDVKALVRPAPITVQRLFQNLHSIARLSGTGSANQKLGVVTKLLVASRGEETRFLVRTFISHLRIQAVRTTIATALARTFALVEHSTTLAPPSNDKERERANMLLVHPSERNGILANATKPKERQDPQRLVLMERLARAEKLVREVRARHPNFGVIVPSLLRYGLAGLSEHVPLRIGTPISPMLGSITRSLGAMHAKLGARAFVSEFKYDGQRCQIHAIYVPRSAGPEARRSVRDDTASSNGGVKCGKWVGTNGEVYVRLFSRHLEEMTEKYPDITDMVPLLMGQQLEAEAPAEREKVTSFIMDAEVVAMDLDGRLLPFQTLANRSRKDVNLHEIKVKVGVFAFDLMYLDGDSLLKSSFRTRRRLLHTRFPPLSPQSPLIARFAHVRSCESTDADQVARFFAQAQEYKCEGIMVKSLDHHWEAPRPSHQNGVDEPVEEEEAEEDEEDDDDDGENDSAPPNARLHKLADVVDDDLAMDNEDEAVATLEAGRGASHVAGEAGKGVNGRGKALLSTYEPDKRCESWLKVKKDYVDGLGDSLDVVPIGAWHGMGRKATWWSPMLLALYEPGTGVLQAVCKCISGFTDAFYKELNVRYAEGSESCVRARYGEPPPFGYEVETGNLFPDVWWRPSEVWEIRGADVTVSPNYTAAIGLVNEERGLSIRFPRFMRRREDKTVEQASTPAMLAKMYFEQQKAAPAPDARDDDDDDEAPRKLAVDDGFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHX8</accession>
    <name>W3VHX8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidophosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHX8"/>
    <dbReference type="HOGENOM" id="CLU_022389_2_1_1"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="548"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="600" mass="65660" checksum="FDB2B0E831F13EC3" modified="2014-03-19" version="1">MCGITALLLASVDQSAAPEINEALSLLQHRGQDAAGIVTCGNKGRFYQCKANGMVRDVFDVNAVARLQGNMGVGHVRYPTAGSSAHSEAQPFYVNSPYGITFAHNGNLINTDELRRFLDADAHRHINTDSDSEVLLNIFANNLQKTGKFRINEEDIFTAIRDLMKQCKGGYTCIAMLAGFGIIAFRDPNGIRPLGMCSRPSSAADGELPLEGHGKDYCFTSESVVCDALGFEDFEDIKAGEAVIITKYAVSRRILTPPADSPDAYAFSPDIFEYVYFARPDSVMDGVSVYRSRMAMGDKLADEVRRQLQKTGESIDVVIPVPDTSRVAALQLAQNLGVPYREGFIKNRYVGRTFIMPGQSVRRKNVRRKLNAMALEFNNKNVLIVDDSIVRGTTSKEIIQMARDAGAKKVIMASCAPPIRYSNVYGIDMPSRQELVAYGRTVEQVAEYIQADMVIYQTLEDLIDSVQQFNPELKQFDCSVFDGKYVTGGVDSAYIAHLEHLRSENAKAKKAATKIPVIAESQKKIYASRASPAASSVAGNDDRLAVDAAPAGANGSAANGNRKRRLTEDEMEEEDKQQDVGCSGPMNGADDIGLFNSWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHY6</accession>
    <name>W3VHY6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHY6"/>
    <dbReference type="HOGENOM" id="CLU_013399_0_0_1"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="175"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="662" mass="70860" checksum="6F0FFACD6D15400F" modified="2014-03-19" version="1">MQPGIKTASSSALVDVSIDGKPACMGYDHEFLFVVRGHLRHVDTSDISKAHVRVPLALVLNASFVSDSDGGSLLVRLLSPPVQAQAREKSVPFAFLKKAKIQPACMESLTQEAYEALSSSARAERLREQLEGPCSSLRLVKIEARVLAGKDGVDSEAKAQAWVDDVMSRTYKDVKPHKRIKVLVNPAGGPGKARQLFEGRARPIMEAAGCKLDVTITSHRLHGLEIARDLKIHDYDAVAIVSGDGLLHEVLNGFATRADAQSALSLPIAPIPAGSGNAMSINLLGVQQGFSLALACLNIIKGRPMKLDLLSVTQPASAFPPGIPVPGRPPTQSLGKHAAKARRDAALNASVSESVRGSEDVARIIEAPSKPFVQYYSFLSQAIGIVADLDLGTEHLRALGDTRFVIGYATSVLRNAQCEVDVDIKLGTRGTKSRAEMRERVLAFNNASRSTDDDPQEQQADGGAASSSLVHGAVTEPLTADATTPPPFDLNDPSWSHSFLTQRHSIRHQAAADPSSEAGATSADGWARIQEPIASLYGGKIPYVSRDLMQFPFALPNDGTIDVAMMLHAGGRAAKLPENGYAESGQLVYQKSMTYVKVEALRVTPRRKEGDKKLKNGGLISIDGEKVPYAAFQVEVAQGMQYSVLSLYGRFCAAVPEPPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIU9</accession>
    <name>W3VIU9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIU9"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000129">
        <property type="entry name" value="Benzoate 4-monooxygenase cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="63033" checksum="125F20B5B6F0A60E" modified="2014-03-19" version="1">MMDAHTVQTAMAAFEQHRIAILALASIASHHLVFRHLELWPIQLALLSTLLVTADTSLRHSTSTPLIAAAKASLVDLSIFTAFTTTSIGAYRLFFHRLSRFPGPTSWSLSKITFIPTDVAGMRPRVIDDAHRKYGDVVRTGPRELSINATTAVTAIMGAKSSFWRGPWYVSTAGSRSPHIPRNLHSAVIESNHSARRKIWDAAFSAKALKGYESILVDNMDLMVNQLEARAQRGERVNIDDYCSFYSFDVMSQAGFGGDFGLLQKGQLSPMIQALEDFMQFVQLVGNVPYLIDILGAMPNPIAEFDKYMAKIVSERKARNEAVPDIMSHLLHEVETKGSTDRMDKEATADARLIVVAGSDTSSTTMGIATFFLMENPSILARLRQELLDVFGDDPSLLTDFTRLDDKTCPLLNAVINEALRIYPPVQAGLQRQSRQANVVDVNGTPTVIPANTIVTLPIWSIQRDPRNFAPHPLKFRPDRWLKPEHEERFNKAAFMPFSYGKTSCVGKVLAYMELRLVIANLVRRFDFVPTQAYNAAKFEAGLVDAFVTRRIHKLPVTVQVRTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ45</accession>
    <name>W3VJ45_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ45"/>
    <dbReference type="HOGENOM" id="CLU_505471_0_0_1"/>
    <dbReference type="OrthoDB" id="3354040at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="439" mass="47946" checksum="04B68DCFA3A09FB1" modified="2014-03-19" version="1">MEAISPSSSYRTVPDLNAGSESEGSTVGSRPSSPIEYETTTTTRHGTALVLEQPTLVSFVPTSEIQTAVSITRDRVVIDTILPPTATLARSTPRAAALGSEHAPLGQEERQAVLERHQAELYELLAKKFTPNYDPTGKIRDDIFTTLTQLTRFPDPPGLKTASDEDRCPCICCELGCDHPLEPHPQQETSRGETSTHLTQEAGQEELHSFLEMDKPRFGRPERLLSLRALAGASDRDGDKRSGGFWAFGRSNRSSSQSDFSQSTQTTSSSTQGSSKPPRAANATAEVGRSRSLSDLVRRRRSKHIAATSTPPPRTDHREAVVLPARTSSQAELRFRAETPQETPQPPPRRSSKRYAIVSRKPVPPHHPTASRSDPALHAALARSGTTAYAIDRIVEEDEGDETLSRRHSALMSSFHAHPDPWSQPLHTPTSTTHVGVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJH3</accession>
    <name>W3VJH3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJH3"/>
    <dbReference type="HOGENOM" id="CLU_463897_0_0_1"/>
    <dbReference type="OrthoDB" id="10054765at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="588" mass="62598" checksum="7EC206E6BB624342" modified="2014-03-19" version="1">MLARTARLRLRATLPGGSLTRSYAVPVNPSSSVDALLGTSVPPPPREGQEFESAPGTYGTPPRFGSKNPNDISDLLRGLRPRDPSGSTQARGSTANHADLQRMKGSAIGAERKGIPIPSRDEMLDEMFKRPLRELEERRNIVDREHPHPIDALYGRNELDERVLAAARALYAASTNPGPRSADAAHTYKAATISQLLERFESRAEYQLSIELPYEPTPSADRKVPLTSAHSSEAELQDANDDGVLLLAYVSNLNGGRGTERISVCSAFAVEGGDKISSEDGDGTGALVVSCAHTLRASQPRKQGAASDSTADADAEPSDTIALAITRAGAIYPVRTLISSLPASDVVLLQLGGTALTLNGTGAGNRPIRTLPVSPYPAHVNSELSVSSFWGWEDDSGAILPEYTFDTERQGLALSDRTVSPPPGREREQVKLERDDAGRSRWGRARLVEYKDPCGASAMVGTYDELAQLDYKLLVSSPANPPALQGDYALRMSSTVTESTRPAAMAAGGTSSTTGQTSVMQSQTRRPLPNFPPPGSSGGPVVDVESGSVVGIVRGHKMSALEGRRGDAIPAEKIFEFFALPGLGRKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJH9</accession>
    <name>W3VJH9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJH9"/>
    <dbReference type="HOGENOM" id="CLU_010913_0_0_1"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="6">
        <location>
            <begin position="782"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="832"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="560"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="972" mass="104027" checksum="EF72AE803843012D" modified="2014-03-19" version="1">MVSAQRSKNIQGSAKSEDVGGGDPGLDARRGAPISTTHRQASFANMSVHSTSSAPSASVSMTMGSSTVAIGAATLCIASPYLSSLLGLLTAAQRVALAVAIYLALCARSQHRSSKRFQVQPPASEDRGSHGHSEATADPDLRTEHLSRTRSSRPSTSAAKVSATPQQAAAPPKDSTVAEKVDFVRSQQCPQLVDACYLDAAAAPPFPTGLVQAVAEDVSSRLLSNPHSKSPSAIATADHITATRMRVMHELFGIRDTHDWHLVFTAGTTASLKLVAECIDWASLQSPSDPHARFSYLRQSHTSVVGIRDLAARAGVSSSIFSEEDADVVAGHAGLVALPLQCNATGRRFCDLMKRLCRTKADRSLVLLDAASYLSSSSRLDFSQLNEDERPDMVAFSFYKIFGYPTGIGGLLVKASAAPHLGGKTYFGGGTVDAILAESAWTKPRREFEARFEDGTVNVHGILAVNKALDYYAQSFGAWDARREYVAGLSDKLVSALRSLRHGNGNAVVRMYRDADGSAGGYGPIVNFNLITATGMMVPPQEVDRLASISNIHVRMGRHCNPGFVTTHLGIPASRLKQEYAEGAGCDDAGDAALEGGLASASVRASLCLLNTEEDVERLVGFVARFFLSTHPAPTLTARVQPEAGLQRRFELASITVYPIKSCAGQELARGEAWQLTPHGLQFDREWIVMNLANGKTLSQKRFPKMALIRPRIDTLTRQLIITIAGTSSRFAVPLDDGDQYSDSQGQATQVCGAEIWPRAHTSRALRSMLSELLGVSCTLARQASGISRHSKLPTATSKVPLIFSNESPFLLINSASVARVSEWMQAATHTGTEDLASDSGYSSASHSKTDSTAVSAQAPSFRANFMVTPRASADDEGRVAFAEDGMSRFVLGGRHVFGVLGECRRCQMVCVDQKTGEVKPQTLKTLAKWRRNARGRIIFGSHLAWLPDLAPSAAAPDEASQVWVGMDVVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJI7</accession>
    <name>W3VJI7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJI7"/>
    <dbReference type="HOGENOM" id="CLU_353050_0_0_1"/>
    <dbReference type="OrthoDB" id="2555881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="796" mass="83124" checksum="E9655983FEC5F611" modified="2014-03-19" version="1">MPRPKTSASHSGSRDGSGEESDATLDPHCSSSAPSRRTRKRPAHMARQGSVEPTSSPASRSYAGSQNASNVADLSDVGEGNSQARSRYTDRRSSGQPHRTVTSAFASPDQARERLVLMQSSSPRVGNAQSAHDPTYPARSNRNTPDARSRLDTAHGAETPHASSSRRTETSITSMSQTRMNGPASNRMQVAEASARLEPATAGLSLHLPPYEAGSYAEVEPARSGPLHPLSSSAQLSAPSMARTASNMSPPRPTRSLPRRRASARTQSRPLLSSSNSASSSYALRSRSSSSSNVLASSSSAANIMASGQNRLNLATGCAPLGGGFDPSNTPSSGMSTPRTPLAEIPLWLADMRSQSRRSSTSSTSFIDRDDYLTASRSAASHHARTLSASSSGPSSPGATRTGSISPVVPFRRSLRGRRPRQSDENARLSPSPSYFGEFETGSAASTRGEMTALDETPDADASPSSSMIHLGTTSPSTPSVQLQASSPAMSTRSRTLNRLSSIRARRLTDPLNAPVTASAPPASDRQDARYAQRIALSSSYGQLRSAVADEQRSASLLERRFAAANVSASPSGPTGRVSSRPTSRTSSPARGTRSSRRRSTAAEGQVGSATDANQLGPIPAGLPPLRIHAARFHRDAALDVPYAVALPGLHDAARSSRLSGLEEAPAAGLEGPAMQLEPISPSAFSEMTSLTQGSTASESVNSVGGLPTTPSSSASLLDPFSRSLGHDAGFGEATASSSRARGEASVRTDETADAGANSAAASLRSDRVLRQQRKNPMAARSGEEDALGLRLDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJL8</accession>
    <name>W3VJL8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_04880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256906_0_0_1"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000156">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="814"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="720"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="856"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1095"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1300"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="874"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1317"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS60951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1362" mass="149196" checksum="E4FBA67AADC47A0C" modified="2014-03-19" version="1">MDRVHARALSSPLGSSSPPSQREPTSMQRSAQLLAQAVPFALKTSSEPPTSSALDHRTRIDPPAPDQSVRQRRSLTHGLRRFFHHVRPTNSKTKQERSDPSFEASCSILKVDRIGNPSLFASLTPSRSLRTPPFSRSVASLSSASSSSSPPSPTSSSSACSSQIIFPLDPDFEAELEIALEMAPHSLGSAWSHDSYNAMQYLRARTPYPPTMTETAFDYHAQGDRQGSGNRWQTALEIGCGPGQMSIHLATRFAKVYGQDPSPNMLKLANTVKRMSAEELAEVNLPPVRDAARIEYSQARGEDPILPPGEKVDLIMMAACIHWMDWEKPESGRSNWQKWSSLLKPGGTLVVTGGRPVIGPYTGEMGERIRPLRDWLLDFPFDYPEVQRYYDTGNTAIEDLRKAGLYRKLPMPWEHSPDLEQLWDRSSYCWIPVDDPTVLGEKATSARLAEVDDPEQLAATMDNLPEWIRPGVRRAAWCDNSAGDLVITTTTPRKMADWTRSTSAYLKFLQENPEQRQLSLQDEDLAAVELKKLCQQIGIDFDAEIECHHSGAVLCIRPSYAPSEQIVERMLKISSLRSTKGERDVTFFGSCGFRVGGPDVEARAYLQSRNFAVRRWTRFRLQQCPAGLRRVSPNSRPAGPLLELVCITMPTASPAAGQQTPPNQQPLIPVGADCELVDSETGSVFLATVISRRWGSPSNTQAGSESDHVQYYIHRHDQDKRMDGWVDQSSVRPVSARPAPTATPAPSDPAHLLLSTATRPGDKGKRKAENELKHEDSDGSRTPSASRQASPTPPDRLPHPRSRKNAPASSPETPALRNIGRVLYGNFDIKTWYYSPYPLHHDDDAVDGSAASSHASAALGANKRNQSPSFRHGAASSPAARRAPPNTGADSPASASRMSPAAGHARGRKDFLPTKMLWICDGCFKYMKTYNGYAAHRKFCRNTHPPGRKVYQRGAHIIWEVDGAQETLYCQNLSLFGKLFIDHKTIYFDVEPFVFYVLTDAANASFDHALGFFSKEKISYDDYNLACIVTFPPFQRKSFGTLMIEFSYYLSAAQGMFGTPERPLSDLGLKGYLSFWTAVLLRALVACFDGPLQPRKGSAGRGRRQSSAARSAQVADQGMEDDNKADASKAARHWNILVQRCKLLDVDIKAISHQPGFEELRKLASEADGQMVAGSDPTAAAAAAQKRKIRLKGWAGSTPARPLRAARIQPAPSDTAHTQTGTMPTSALTASYGPGAAAADVSHPALDLAKLRADEPCTMSVTLDALSRLTYIRPDDIVLALSEAGLLNAASTPFLPGSDAAVSQNGASHDESARANGKSSNVSTVTPAHGQPALLLTRDAIRSAIERFNVRPAVLEESYALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJN9</accession>
    <name>W3VJN9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJN9"/>
    <dbReference type="HOGENOM" id="CLU_039766_0_0_1"/>
    <dbReference type="OrthoDB" id="2553968at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="532" mass="56802" checksum="AE4BB18A7DC54DDA" modified="2014-03-19" version="1">MSGRGTGSGGRRSSSNAASRPSTSRAAEVAGPSTHRFADRRQERMRGAGTAVAMQRDFQFKLPAKKSAPSTSATARAPAASTGTQDTSVSTENSETRRRPGRPRGSGPRQKERAAAAAAAAAAASAESSPDVSVVVDADTSLLPDQSLNSSRPDASASIGVPRRVARPHSSAPISSTPAPSRIQKSSVASASRASQRNARDADEDVDSQLGDEDDYSLPGGGAALDASPGWDAGLDDMDESLPVIPSPAASSSNVDTSVRRTRPSVGGASVSRLSVADSPSTRAHVDSPAARAAKRSLDARQRRRQGSPGTERHSAPTEKRRGRPPKSAVPAKSRSRALLREPVEQDETVMDRTMIERHRGGAVGGPARSGRDLQKRLKRALTLVYSATDADEGDEAGAPSAKKRKSGKYLNDVDIIWSVVDEELRSAIEEQPAKAPFLALKALRKSVRSNFLNLSEKTDSRTTLISQLVRARKQKRQLRKEVFACRSELAKSTAEAGERTREMNDWKKEVTDVRKLNAFLLNLRHQAAAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJY6</accession>
    <name>W3VJY6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJY6"/>
    <dbReference type="HOGENOM" id="CLU_002633_1_1_1"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000080">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="485"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="689"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="921"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1188"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1220"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1243" mass="136746" checksum="1A36AF6F9D9B3F5A" modified="2014-03-19" version="1">MVAAAAALVASSAASGSPAVPSAKDDSQAQALHRERDRKRRQLRAVNVGVWSAGPAPPSQSLDSNLKKNTAYIKRAKQSIGHDARDQLLKDLPQLNLEKYLQELIQAVSEGLGRCVTAKDCLAATEIISAFHARFGSTTFSEPLTTSLEHALAPPSKTLYQSATTEQKERDEAARVARQKPLLRVTAELALVDVVGHTRDAPTGCDWLFNVIKALLATDKDHANVPLLISVLKGLGQTLLSPAASLTRDDESLLADKASGALTIGDAVNAPDFAALDPASAPLVSSEMQAKFRKLFETYFQTLARRVVKEHQRLQDQDRKNHEAYIRSGEIFEDRQQNYERMTKSFERVRDWARILSDLLGVDMPDLESSASATTAVGLGVNLDSKSAFERADEEFAPDQSPWEDQDSQKFYEDLLDLGDIIPPSILAQTTGIHAASSANADKQDAAEDGANRTEEDKTSTAASTPQLDADAGDEAMNAGPAAQLATLMAKLPDMTNRSMIDSAAVDFAFIATKPARRKLVKHLASLPRNRIDLAPYYARLAATLSRYMPDIGAGLTALLEDEFRYLQRKKNVDLTETRAKNARFLSELTKFKVTPTHAILHCFKTCLEDFSGPNVEVVASLLEGCGRYLLRTEDTSVKMRSMLEMLRRKRAAANLDSRQLLLLNNAYYQCNPPKRKAIEQKVRSPLELYIRHLIYHLLAKKTVDTVVLQLRKLAWDDASVYGWLKDAFTRAWRIRYSNIHLLAILVYDLDRFHPSFAVDVIDQVLENIRIGMEENIFKHNQRRVATACYLGELYNYRLVNSGIVFEQLWSMVTFGHPKGRPWPGQVAPLDAPDDYFRIRLICTLLDTCGVCFDRGSLRKKLDDFLVFLNFYVLCKQQPLPMDVDFTLTETLEALRPELKFRKTFGEAAAALEEMMAANRQLAPQAEADAEEESDGNSSDARRHGSRADAHEASAPQGSGKRRRNKARNQAASDASDSEDSSDSSSSSSSESDSSESASSSSSGDSDASDSDGSESGSSDADDSDDEEAAAERHLLNEELAARREADDEFDRELARMMVESSGPGTATAQSSAGASTSQRPHQFFSRAALPSGGASYGPAHSHAHAHASGSSLSEIGLPIKKKAAEQANGGVEAEAGSHMKFSLLSKKGSKQVTHEVHVPATASIAINTRTKQLKEEAERRQLKQQILAYERSSESQQHSGLQPHGVVRRQQPQQHQHHHREDPANKAASKGDDFKIWTSHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKE6</accession>
    <name>W3VKE6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKE6"/>
    <dbReference type="HOGENOM" id="CLU_070644_0_0_1"/>
    <dbReference type="OrthoDB" id="2546640at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="339" mass="37022" checksum="85A28C3AE055048B" modified="2014-03-19" version="1">MDISACSVCFESGASSAVDAVSSLLQGPHTCSALASALREHPFNRLSALPSPRPLSPSACATGFYHAHRSPASLYLVSAHNQYDIVSPIPLDPRSREPYLPTEAAASMAVFKGGPALPKRTERADEGDDAMSGKRQRRTTELLSNPIHEGQPDDDNSTTQRNNSRKDANKMPMVIEGGDTAKPVSELRSTMDAEMDDAREGSTTPVKEEFDLPPPPTTPKKRSKVKAERNDLLKTPTKKEEAGSSSAAQRSPREQAPLASAWQPEHWDDLNFAILKVVQDHAAELYDASPSLAPWRIKGRLLVKLRQLMKDAQGGDVASKRWDVEMKPNRTKASPKKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKL7</accession>
    <name>W3VKL7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKL7"/>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1080" mass="122770" checksum="326CF9CA12DB1AEB" modified="2014-03-19" version="1">MEAILDFDKDLDIGLLDRVVAAMYTGAGQDQRMAQQTLAQFQEHPDAWQRVPPILQQSSSPQTKYISLQILDKLISTRWKVLPEDQQQGIRNFIVEMIIQHSSDEDSLRREKTYVGKLNTTLIQILKQEWPHNWPSFIPEIVSSSKGSLSICENNMAILRLLSEEIFDYSAEQMTTSKTKSLKNQMCGEFGEVFQLCSEVLEKAQKPSLIKATLETMLRFLNWIPLGYIFETNVIDNLIGRFLEQPEFRNVTLKCLSEIANLSVGPEYDPKFIVLFNMVMTSVNRMIPPATNIAAAYETSSDAEQELVLNLALFLSNFLTTHLKLVENPDNKDVLLNAHMYLIKVSQVPEREVFKICLEYWSKLVSELYAEQQSQPIADMNPLLGLNLGNGLSNSANSANLRKNIYADILSNLRLVMIERMVKPEEVLIVENDEGEIVREFMKESDTIVLYKSMREVLVYLTHLDVLDTENIMTEKLAKQVDGSEWSWANLNTLCWAIGSISGAMHEETEKRFLVTVIKDLLGLCEMKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKNFEFMHESHEGVQDMACDTYIKIAQKCRRHFVIQQAGEQEPFIDEILRNLHRITLDLSPLQVHTFYEAVGYMIAAQPNRPTQERLIAKLMELPNSAWDSLMQQAHNNVDVLGSPENIKILSNVLKTNVSACVSIGTYFLPQIGRIYLDMLALYRSVSGIISAKVEAEGLIATKTPMVRGLRTIKKEILRLVETYVRHAEDLEAVNVNLIPSLLDAILGDYNRNVPAARDAEVLNVMATITSRLQGLLTDKIAPILDAVFEPTLNMINQDFAEFPEHRVGFFKLLRAINLYCFPALLELPPPKFKLVVDSIIWAIKHTMRDIADTGLNICLELLNNISGSPLEVANGFYQQYLLNIIQDIFFVLTDSDHKSGFKTQCQLLARIFELIETDRVTAPLWDASTQTDASMNNRLFIRQYTSNLLRTAFPHMQAEYVDHFVNGLCMHSSDLIAYKLHLRDFLITSREMFGGSAGQVDNADLFQEDKEAEAQRKAAAEREAAAKVPGMLKPSQIKEEDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKN1</accession>
    <name>W3VKN1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit sigma-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sigma1-adaptin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03628</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKN1"/>
    <dbReference type="HOGENOM" id="CLU_702315_0_0_1"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="12">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SCP2" evidence="13">
        <location>
            <begin position="290"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="393" mass="44277" checksum="3BA5101173D2FA2A" modified="2014-03-19" version="1">MAINWILLISRQGKVRLAKWFTTMSPKAKLKITKDVTQLVLARRTRMCNFLEYKDSKVVYRRYASLFFVTGISQGDNELVTLEIIHRYVEVLDRYFGNVCELDLIFNFQKAYAILDELIIAGEMQESSKKSVLRTVSQSDAIEEAEQSEDADPRPIQQRSSDGEEHREDKRGRNNEPGRIEGLVTTRAKRPTGHHRQAMRVTTTAPNSAPEQHEQDRQERCRSSRIGAPICGVEPFCTSGSQGTELAGKGRSANFPRSLALLARQRRLRSDMSDFKSQALFEQITEGLKTMDDKEKKDIQKKTNGVFEMHVKNAGGKELVWTIDLKKNAEAYEGKAKGKADVTINLSDDTFIDLADGKVNGQKAFMSGKLKVKGNIMLATKLDGVLKAQKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKV9</accession>
    <name>W3VKV9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKV9"/>
    <dbReference type="HOGENOM" id="CLU_323943_0_0_1"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="874"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="740"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="903" mass="95705" checksum="C0C40EEDFEFBC407" modified="2014-03-19" version="1">MSSSSSTSSKPRSSRQDRLPQRHPARINTAPASSHRAHPPSRSDAAHPSLAQLRHASASKSSTSPHACHNCHQMDTCFYCDPCLSSRIAAHHNEIRRLSLAKDKARQSVEMLLSDRAHSEAVGAIPPSSSATQAIPSATLAMPAALPDPFSITASEATAADSPHSTLLLQPLVQLRARRAALSSRVQNIHQCIAHSQQSRLESQEALQEQQASIVLRKHNLAKSWSSLEGSSAVSSPSASQRARHANKSRWLTHPAADHIDTPLIFTDVYTHYERQDEAPPTDSPAEPVDLQLGAVITRSRLQLASLQAEATAISAELANARATLARDAFRLFSVSPPDSIQSLKTVVSPTPRSRRVNLSASSSVAQRISKLSERYMPGAFGLSQASLTHAAVADQASVASTSTDPSDSRHGSSKSSWSIAGLPLPLPSEVRRHPREDVNGAVTYAINLIQLLATYLGIALPFCIEQHKGRFSLRPDALWDGGGGSSAKTLYLSSRAYAHLSTTAPSTQRSSKLNNLAESTIGLGASTLSTIESYIHLPSGAGLPWGLTANQTPNSKNASGSHDADSEARQEARTDKGRDSALPSGGSSTDARSKPDQAARSFVSALVMLSYDVAYLAVKQGIQLDLVAAAANPLHLLSMIMRQSDLGRRAHANHISASGIADLSLHSLDYEQLAQILEPNNAAADGYKRGGSSRSARSDLAEAPRPRVAAGPHKMLEQSYVDVGEAAASVLGLRDPSTAARKPSARQASAAPAAQTGEAGQKMSKPQPAPRLAADDGRSQKRTASKRMPSTSAQPPPSLEFLRQRGRDASRAKGDAGPATAANHGSERKDRASKPSRQATVPEDEAGTQASRKIGPGAVIFNGVEVGVGNMSVDADRSAAGPSRGPREKHRKHATDEGWDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL16</accession>
    <name>W3VL16_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL16"/>
    <dbReference type="HOGENOM" id="CLU_339841_0_0_1"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833072" evidence="8">
        <location>
            <begin position="32"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="782"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="901"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="970" mass="102998" checksum="31F2D3E61DDE35B3" modified="2014-03-19" version="1">MFASAQAHQAWRALTLALVSMLVWCSPSALASPTYAPLESRSQSPFLSPGASTENYDAAGVQRVNVTLAVMSRCPDALACEAAFDKVLDRVNAKTRLTMTYIGTPDNDKRQHRYGAVCKHGEQECAGNVQQLCVQDALNPVRAGEDFDLSPSAAQKKWWNFLQCQNYAGLAKIGDEDLAQRCLRLIDGPAWQKDGIADCVHGKHGRKLLQRSVKASQRANTGTSCTIVFESGKRCIRDGGAWKNCDLGHEPADFVAEIERIWSDKNAKAKLDQSSSPLASQTIPQPPSRLNKRQSSTSSAPPTQTDYNNPFAGSRTPPSVFVSSIKDRTSLPHNASTSDPRQLPLLAPALVQPAVQALATLAPCSPAHHVHPLTMLPRPLSHPHPLASTPHFRDADPDHCSSNPFPFSGPNLPVPFLAFAVTAIALFVIVVCFVLLRIVMRNRRLRRLGLLPDGPFDRLLGPTREIEDTLPPPKLLEARIAHDFRPTALDADVKARGWDAVMPISAAVPPVLYSDLFPNNAKSKGQDNTTNTANGQVPGEGQAADGAASHSYPPTSASSGGLTRRLHVPSFLRRNGDASHASEGADDSSHGALNESGAGVADGDSKRALPDTSTPASVNVTVLIAMPSQRTVFPSAHISNNASALKSQRSLKLDPAAAAKIDEVEEGADDASRSLRRTASIKSFRTAASAKSIGDARREAFFNKMNQDEGNTANAADIHNTHLDDEDEEELPELVFGTASVPIFTRIHGSAAGREPFAGTSEAYQPLRSELMRLVTNAHEARERKAAMEAAAKQAEKDASNEDDGQTTIDARSTTQGGVAANARNADGTTNGPRVSGSETIDSETAAVIGAPGLSTVPAAAHQEGLGDVVTRMMMPEPMVTQHGNVALGADPVPASAINGPLTRFSEDPRPSIGVNSNLSRDEMTTPAPGDGPGGYNTSTLTLDPLLGDRAGTYGGADQHTAAAATRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL61</accession>
    <name>W3VL61_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-3 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03491</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL61"/>
    <dbReference type="HOGENOM" id="CLU_015354_0_0_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="426"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="534"/>
            <end position="535"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="559"/>
            <end position="565"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="584"/>
            <end position="588"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="653"/>
            <end position="656"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="708"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="736" mass="80560" checksum="B8D82878642B7198" modified="2014-03-19" version="1">MAPAPSMLPYPTSFHFGSYGSSAPESQQKADSRQTRCLGGRALAPSLHEPSAHFDFEAQLSLAYGGAASEPSSKPGSLLEDLPVVCNPAAPLQCSALHCKSQLRSAAPLDFLQPAFHSPQPRHLPFSLAHTHTNAHTQTPCTDASSCLPANLPAPARPLLPRSETALQRARPVLCLCLCRCLGRPSAAPPVFGRSPSCIAIAENILSTSTRRRLNPAQAKPRQALQPLPTVYIRSLRSSSSLVTPSFCLLLSCPQFRKHLDPSALPTRLDCCAPIYHSGDIGSDDAPACSPSGLGTRSGTTKPLRAIPPPPQFASAKLGSGLDRPWAPPKRTAIRRSLTLGLSPDSAQHLSTSKAAVAASAPTHAGFGLESTLGRSKPALAKMGNCLSSTDQKEAKDRSVAIDKQIEEDSRKFKKECKILLLGSGESGKSTIVKQMKIIHQNGYTKDELLLYRLTVIKNLVDSAQAIVLALRKFKMEPEMPENRENVDAILQYRVDADPGATLDHAMARKVDSLWKDPIIPAVMERGSEFYLMDSAAYFFDNVNRIGQPDYVPDENDVLRARSKTTGISETRFNMGQLSIHLFDVGGQRSERKKWIHCFEAVTSIIFCVALSEYDQVLLEESGQNRMAESLVLFESVVNSRWFLRTSIILFLNKIDIFKQKIPKQPLSKYFPEYSGGPDINKAAKYILWRFTQTNRARLSIYPHLTQATDTSNIRLVFAAVKETILTNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL76</accession>
    <name>W3VL76_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL76"/>
    <dbReference type="HOGENOM" id="CLU_1094140_0_0_1"/>
    <dbReference type="OrthoDB" id="10249858at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834309" evidence="1">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="254" mass="27682" checksum="E5AB3E40C7A0B5FB" modified="2014-03-19" version="1">MVRSSLITLAIVLAGCHAAPSAPRRTDTESTQHPLAYASLPYEPETAARIPPSLPDGDYAFSFKQHKWNYNGAGVNHMSTGTWYSSLSQAKVLVTASTLDWASDNATLAGELTGAYTSSLFDYADTSAASKANVKNYYFASDYTKPVGTGTCNANELPIGAAQGQLLPPDFLRQNGIYAGTELLPQYGQADKWVAFFGPGLALSFYFVTAIDGHQRWVRYDQYSQGEQTTVVTEIFDLRENAQFKAGLFNPCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL86</accession>
    <name>W3VL86_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL86"/>
    <dbReference type="HOGENOM" id="CLU_049768_1_1_1"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="12">
        <location>
            <begin position="239"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="417" mass="43883" checksum="87BA6C0362F1A514" modified="2014-03-19" version="1">MASQPPQQEQGQGQGQGKEADSGSAFFDTFFASALQRANMSTGELRGLTDQISAAAHPVAAGRNDDVYAPDGNGLDCGRDPGDVPAPQPPKEHATRQQTSALANGVSALNLGAAAPAVASSGSSYVQATSSPSTEGSAGAQSNAHAAAAALLSRSTSATAVHGAPATKMSADLDVLAQTRGGGLGTPTGERTYIGSAWAASGAATPVMDPNGLGWPAKATLDRLNHTPAQAEANQARLAAAIHTVLECIGEDPTRSGLVKTPERYAKALLWMTKGYEVRLSDVIANAIFDEEHDEMVIVRDIEIFSLCEHHMVPFTGRIHIGYIPNRLVIGLSKLARIAETFARRLQVQERLTKQVALALDEALRPQGVAVVVECEHLCMAMRGVQKPGATTVTSCMLGVFRDRQKTREEFLSLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL96</accession>
    <name>W3VL96_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Squalene synthase</fullName>
            <shortName evidence="5">SQS</shortName>
            <shortName evidence="5">SS</shortName>
            <ecNumber evidence="3 5">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="3 5"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL96"/>
    <dbReference type="HOGENOM" id="CLU_031981_2_2_1"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000034">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="574" mass="65382" checksum="FAFA4C2B263707E7" modified="2014-03-19" version="1">MSLLQYVLLGITHPSELRAMIGYKVWRDPLNDIKANPVESGWDRERMRQCWTFLDLTSRSFAAVIKELKGELSRVICLFYLVLRALDTIEDDMTIPADKKVPLLVDFYKYLEQPGWNFTESGPNEKDRQLLVEFDKVIAEYQLLDQGYRTVISDITAKMGAGMASYIELSGKAPLSVSTWKHFDLYCHFVAGLVGEGLSRLFSESKLERPWLGHQLELSNHMGLFLQKTNIIRDYAEDCQEGRFFWPKQCWADDYARFASQPDVASGIVETKPGSGKYKPADSELGRRSMYVLSSMLLDAMSHATSALDYLALLKEQSVFNFCAIPQVMAIATIELMFNNPDVFKKNIKIRKGVAVGLILKAVNPRDVAYTFLAYARKIHARLTPADPNFARWCVELARIEQWCETYYPGFVANEGGSDDVRADGLKQWSEKRRTQALIMKHAKLEGRDPTSMDAKEAIEAAKRSALDPRDLMTEDEKKALDKKDRDEMMKFFILMLAGMTLFMGIVALATWEIIWYWTMDTPDPLSTSVVQLYHSARQEGYATVVEILATVRASFEHVWKHGINSNSNAKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLC8</accession>
    <name>W3VLC8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PaG_04093</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLC8"/>
    <dbReference type="HOGENOM" id="CLU_019326_1_1_1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834328" description="Inactive metallocarboxypeptidase ECM14" evidence="20">
        <location>
            <begin position="23"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="21">
        <location>
            <begin position="165"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETS61607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="522" mass="57131" checksum="ED9C69060F69F629" modified="2014-03-19" version="1">MQRTLAARLLLLTASLISTATAVQQPFDATPRITFTSAAESHGVADFTGQQVVRFTTASHAQHQALLQHAHVLGLDVWAAHRGSACSTSPDAHVYGCVDVRLASEDGAERDWMAQLMQPFPQHKRPHAQTMIEDVQQLVAAQRSAVDEEEEEEVEAMREDKWHRDYHTFDEITAYMRMLEHSYPTHAQLVQLGTTHEGRPILGLKISDDLPVPTPDPQPEPQPDPPANTTASARGKLGIVVTGGQHAREWVSTSSALYFASDLLAAALGVPSNSSSPVEAARRGKKRARKVWSKKQARLMLSSFSITVVPVSNPDGYVYSWDKNRMWRKNRQPNHFPSGLFCKGVDVNRNYDYGFASSSNACSEMYSGSAPFTSAEARAIATYVEDARNGVVGFFDLHSYGQLMMYPFSSDCALQPADEEDLLEASLGAIKAVKAVDGKAFTAGKICEVYAVAGGNAVDWAYAASKDTQGQQKAKVKWSFSIELRDGGTYGFLLPKKQIVPAAKEASAALAYILSFIQKKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLS7</accession>
    <name>W3VLS7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03146</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLS7"/>
    <dbReference type="HOGENOM" id="CLU_108590_0_0_1"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="222" mass="24959" checksum="87DAD0E73E47CF33" modified="2014-03-19" version="1">MASTRRTALPLVYAVLRAPTLLLRPTLSNTTQATMSGAATTQFSLPFRMFGTRNTADDAHALCLYPLRLATLDVSSFLSINLQRPLSIRDRPLMTMISDPPVPYRQDLPPSGGYQPIRYKRNLPGKNLSGLTIFGGVIAICAYGFYKVGQGNLEQRELKRERAWSRIHLIPLLMAESDRDAFRRSEAQLAREKEIMKDVPGWEAGKSVYNTKRYTPPNFVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLW0</accession>
    <name>W3VLW0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLW0"/>
    <dbReference type="HOGENOM" id="CLU_454307_0_0_1"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834339" evidence="3">
        <location>
            <begin position="37"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="652" mass="70376" checksum="6C12C6A80E3718BE" modified="2014-03-19" version="1">MSTRGRASSSSVLRGRLGVWCVWLLLLAFCSGRTAAQQISPSPTTSASSSSIPPPSRSRSAIPGRATSVLNATVNAVALNDSIVARSRIDVNATQGAFFNFTLPASAFSEDAKTVTVWTSISLCSGPAIPPYNTSNTTLLQSLDRSATEARRSTLAALYISDNVLFQQPGPANASSLDSRHIGYAQGGWTSVEVDVQQSSENSSETLWIGVWPPADTRNTTQGTYQFQVVASTRAKMESVDYTRRPRLDDTDATNALVSSFNYTTSLPPMLNAIVLPTFGEYSLPDADYFNSSFCAIADAWAELLNSNQPFSINSSATRRGTEANVLNDTRLQFEISGLDSGTNYTFWLVESTNVNNDTAAQSLTTTLFPAIKMRTKRSDNCRLVYDVPFCPNVAYSIPVDPSISTSNALSAIEAFVSPQYGNFSTMIDTFPCGDPDFGMYSYVQTCDKCKKSYQDWLCAVAMPRCTDALADPQRQSRATQDSRNLTGAPTGTNKDLLPYIVNRNSNASGSVALASRQSFIDEQLQPGTYGELLPCIYTCYFVERTCPPLIQWACPVWDITAQRDYGTFADSGSEGIGAGFNGGAGKDGMRWGGYQRYIATDAFGNAYCNSMGVDFLLRESNSARRSIAWGSSGGGLFAVSLAASLVVALFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM31</accession>
    <name>W3VM31_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM31"/>
    <dbReference type="HOGENOM" id="CLU_027816_4_2_1"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="114"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="549" mass="59691" checksum="1A150DABBBAAF647" modified="2014-03-19" version="1">MASSNLETPAGLSNDSITTTSAVARDTNRSTSPSPERKSETSSRPVGSSFLFPSGERAKSWQDSYLFELLGERGAQMYETSEKGQNVQVSDIEEVTKVQQAQQNAHDHGAIPKTLGWKGAFFNQVAYAIALGILSIPLVAVSLGVVPFVLLTFLFAYICWYTGDQYWKLKMRFPGVQNLQDAGFLMFGPWGARFLGAAQFIFSVFLQGNHVLLGAQAFHVLGWHSCAIALAAVFAVISFLFTLPRSYKLFSISAFVSFSSIVVVLFSISAFVSFSSIVVVVIFAMIASGVTGPQNAPVGAPPIKVVAFGPAPGIKVDFLTGFLYVLNLFVSFGAIPSYLPIISEMRKPTDFRKSLFVLVGVQLVLYLIVGGVIYNNLGQYTTSPSLNSLSYTMSRIAYGLALPTILIAGCESGQVANKHLYIIVFRSRPQHIHNSTKLGWIVWTLINALTWVLAFILAELIPFFSSFLGLEAALFWSLFTGLSAVMWLYLNQGRWVESWRKIVGLIVAVLVIAISAVICVAGVWASAISIRDSYNTGSVGSPFSCNSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMA2</accession>
    <name>W3VMA2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stealth protein CR3 conserved region 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMA2"/>
    <dbReference type="HOGENOM" id="CLU_005484_2_0_1"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003976">
        <property type="term" value="F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046835">
        <property type="term" value="P:carbohydrate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth protein CR3 conserved region 3" evidence="4">
        <location>
            <begin position="608"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110942" checksum="41977A87DF7E699B" modified="2014-03-19" version="1">MAKPFRLAPSRHTDFVEPHTEIRGVAADDDHADAVAPILAFRIVSVALHPASDLQQLALAMTKSFEGYGPLTAAYMWALLTCLNVGVNRKALPSPAAAPGRPWPALAGPRLDFPGSSARIRARRAVVKIQDLAVPARVPLMVQPRLVPAQRCGQSVKRQPQLGASSKAWRYTMLRYLRPLTEPFSSRYRQYLPLPTSSPRGSVSAQGDAVSTNGSAPGCPAKHVSSTNAQRSKVGVRRRSLSWHLRLLLLLAVFAFALHATVRHFFFPAAPSSEASRAEALAMLTDQLATESPTPASQASASLHIEAKTAASPESVHRLFADSSPGAASREVMPIRAYDALSDACIEQWVVHHRWGDACRGTDMKHSLRFDAVWAWVNGSDPAQILARNTYKPSSPINVDAAHRYADHNELLYSMRSLYHSFGGHSIGKMHIMASAYPLPQEAVSSLGEPSNTTLYAGQIPYWLNASSNSQQDKIQVHHDAAYFRPMQLDGPNKLSPAEVDAWRAQTLPSFNSLAVESQLFNVPGTSSDQLVYLNDDFFTMVPNEVSDLSSALFGPVIKSDTRLFSFYRPSEHPFQRHWNPAGEEVGIKRAAWILGQRFPMRSLPYITHHPRTLSLPLLREAAQTFPEAFSNTTLARFRAQKEVPDSIQAFFLASWYIVERHREALLWSWAVAKWGGRDGVLDAATKRAMWDEIRMKTSESKDVGTERDADTFAVSRPVRRSRDQDRVVFEHAGVPAPKNTEYSFSSHDGHALSYLDWTWPWQRSRNGYPDLSEHVQERGHARSWIPSSSSGSSRSSVCRISYSACFAPQNERESADALFKRIAFAPDTASKCGDCIMAALLTASGESGISAFLPPDSAAIDVPASSDKMGSRAHLPLTESWRATDFSIDSVLQLSSEHASASETRRISLRTWCTRLIQRYQYVLGATPSTFYKVEYASRLPHQLEAVDRSLAEDSHPTTFLCLNDDIKESTQGTLKLNRILKRWFAAHWSRPLPGELGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMD9</accession>
    <name>W3VMD9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMD9"/>
    <dbReference type="HOGENOM" id="CLU_042700_1_0_1"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="497" mass="54494" checksum="8943BA8F85193C3F" modified="2014-03-19" version="1">MTIQPAEGAPVGGIRRIVTGHDAKGVSIIDKDDEIERLDCTPEHAHFAPGDGAKKPIFSGRSHNDNGSVVRFVDIPPGCCSPMHRTQTLDYGIVIFGEVELELDSGEKRTLRQSDTCVQRGTNHLWRNNTDQWTRIAFILLSSKQIVIDGKQLSDHGFPADPTQVFPQLLQSRLFSTMNTTRKGIHRAPIGFGPAPSPRQAPDGSRFDWSQARTTTVVVEVERECVEALLPPGYTVSDSVAHPTVLFEVMELRNLPWLAGRGYNTLGVYLNDIVCNRVQPAITASYMAVLFENFTDPITTGREELGFPKVYAEISNAIVSQKEGVESRVHTLSWGGFEFLRLELALTAYAVQNSPAMMPDARRYTHPTKDGILHQRYVPAVGELGKSDADYATFCPPPPPSGPPKVLEFKAPPVSCGGDEVCPAVVQVQPDQKAEGTHEFCEGAVKLSVKRGSFDQLPTLYNVVDALAGLKVRACREVAMHTFQGASDLAANHRVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMJ1</accession>
    <name>W3VMJ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03542</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMJ1"/>
    <dbReference type="HOGENOM" id="CLU_031625_2_0_1"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="95"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="206" mass="23138" checksum="D1C6F9E9D1F00967" modified="2014-03-19" version="1">MSEHTLPQLPYAYNGLEPAISEEIMTIHHTKHHQLYVTNLNNAIKAYNSAISSNDVRKQIELQSAIKFNGGGHINHSLFWKNLAPAKEGGGQLHDGPLKQAIERDFGSLDNLKSSFNATIATIQGSGWGWLGFNPKNSKLEVVTTKDQDPLISHHPIIGVDAWEHAFYLQYKNVKADYFKNIWSVINFKEADERFKAAQTDAKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMW5</accession>
    <name>W3VMW5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMW5"/>
    <dbReference type="HOGENOM" id="CLU_437491_0_0_1"/>
    <dbReference type="OrthoDB" id="3366659at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="622"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="661" mass="70014" checksum="CC26266225FC33F3" modified="2014-03-19" version="1">MPTEDQDTCSTQLSPRRSGSLHRPRSHTPTPRISSQQIRSLAEASIMDSSVQSPNAAGNGTTRLPGLAGTQSEKQLTQRELAALKTIKRNVDTTKYGGWMLGAAGTFVLLGRRKPPPRLLSKLGWSVVGGLGGSFLTMPIGIMMSRGALKDVEDPQHLRMVLAGAIEEQRQGRKPQVSVAPPKDLDGETDAQQEWGGERAVQPEAASFDSTGNLKTQGGSDSFDSFSSSQPSSSTRNVRGNAGMPAAGPSNDTESPPGTGAGTRWAQLRGERSVEPSKWERIRQDNARTAYSRSGSAQAEPSDTPSQGAQFSSPNSAPPSRPSRPAPRSRDEPVMTLSGDQDDPRWSSPASFSPQSSGWGGGEFLDDPAGGDKDATQRSRANGRRGYGILSINEERAPSSGVEIESDAPIQVVKGSLLTALGGGLFGSAYGVLKGRQGAGMILGTRMAMSSFAFAFPFFAVREYVVSPVLNRTSSGPDPANRSMRLRTVTPNRHTHNLLASGLAGAVVGAGAAAFTRGPRAIHKGVATFGLACTALQLVGNETRIVRDALLRPSPRPVPVAASPSSPDAAVSASQAVAPMADVQPTPSASEMQEAKPQKSASWLSKVKNAMPIRSVTDEEYEEKLNKRLTSVNQRMADVETEIREIEALLQQKEAGFQPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN70</accession>
    <name>W3VN70_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN70"/>
    <dbReference type="HOGENOM" id="CLU_012349_6_1_1"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="70576" checksum="B57D86BCA07575E2" modified="2014-03-19" version="1">MSSVVATVTSTAAAGPTSSVDAADAAKASASSAVHSLSKAIASASAALTSESAIASGNEANPPAFKYVGLALAVGSGVLIGSSFVFKKKGLLAAQKKYETAAGEGHAYLKSAMWWTGMIVMVFGEIFNFVAYAFADAVLVTPLGALSVVICAVLSSIFLKEKLTLFGKVGCFLCIVGSVIIALNAPTSHVGGKITEFQKLFLAPGFLTWAGVCIVASLVLIFVFAPKYGKKNMMIYITVCSLIGGLSVSVTSGLGSAILLSIRGQNQFKHWFIYFLLGFVVITLLIEINYLNKALELFNTATVTPTYYVIFTGATLITSIILQQGLNASAIDIVTLVMGFLVICAGIVLLQLSKIDPDELQDKPGLDRDTTLLIRASHSVISHGGEKAESSAYEDPGVDTVRGGMGIVGSMIRARSSRRLSSASSWGRQHHSAADEYTLRSRNNLPLTTHRAGDIERYQLQDAPLSPRGLNRDSSLLSVPNTPSRRETTIQFTPDADSPHGHHAGEGSARDARYRTAPAISQFGAINTLHSIKEGSNGSGRSGEASGSGSSAQQRSQMYVDPYAPRAHSPLSPTMPRSDGAPDIRNMWDQPDLGYASSPAASPETEEDGYSIRAVASSVGADQHSGSGRSKTKEYPKIKPRSASKSMGKGSSDDDEAEELLSPRLGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNA6</accession>
    <name>W3VNA6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serum paraoxonase/arylesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNA6"/>
    <dbReference type="HOGENOM" id="CLU_437551_0_0_1"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834724" description="Serum paraoxonase/arylesterase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="70603" checksum="95825561AE1B47FB" modified="2014-03-19" version="1">MLVPLIVSSVAAGLLSVTSYFPYKNHLKLHGDALDASSLGSDNYRLNLEHCQPVSTRLPNEPAGPVEPSFCEDIVLDRRTGVAYLSCDPTRLTWDARAGIYEDGSDRLASEQGTPGIWAWDTNRRSLPRKLFISSPPPEYPIQAPADLQSTFHPLGIAVTPSHPYFAEEADEGEEPRPEPPANLVLVANKPYADRPGVVDIFVHDLDKVGGKDHTTLRWIKRVQGDELSGMQLDWDTHFNVDPFRITVFEEQYSQRMDRHYPEPTYVKEDPEHLAGFQDDDPARIAFKHIRIPSFFITSLPDRAAQPTPAAAVERSSVFSAMWQPIASTLFSQYSLSADTVSRKIFLHHSSINKTLAVRMDGGDPDLWQGFPPLIQAWDGGGKKTGSNSSATALFVPSLTSDAARVQEWEQHWVRGVAGGIREHRVHLSETTPEGKVNNILQLFKTYTPSFVNFFSMDHETPVRALVVDPHGRTWTAGNPNTRSVERWIAAQRNERRRRLGLPLAAGASQSLSSSDRPPRPAARIDQTTWVFRHFGSVVAHPWQTDKLALKKQKGVWLRKEFHTFNVFKSPSETKAEIEARTEDELVKRGFLPTVPTGLAIDIHKKMLYVTGAYEERGIAMCALPADWVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNE2</accession>
    <name>W3VNE2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNE2"/>
    <dbReference type="HOGENOM" id="CLU_029871_2_0_1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833250" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="88"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="489" mass="53334" checksum="4E23E1CF82E0ED32" modified="2014-03-19" version="1">MKLLAIIPALSILLTSVAAFPSYGDLSKVDYSAFLEKAAQIKGGQELIKRATNNSQTTGFEQRTFHALINPASFKFNPQEQHIDLTSEEHKFIPPGPNDIRGPCPGLNLLANHGYLNRNGVTNLFQGIDAIGKVFGVEADLGLALNAYAVVFNGNILDLSWSIGGPYKSQGLGQVTDLLFGTPGGINAHNIYEGDASIVRQDYYQPGANHDNVQVHLPYFQDLLDLGNNDQTEDKDVYTAELMLKHKSNRWHQSVETNPLFFNSAFGGLVVTTAAERFVAEFAANNTVDENGYNRLYLDEKNLLAFFSVERTANGLKYTPGHERLLPGWTRRPLGATFGLDDIVLTLLHAAAIDPSLLSVGGNAGKVNTFTGVDVGNLTGGLYNFETLAKDPQALACYLYQIGIEQLVPTQINVLYKVTGQALDFVAKYLTAPWKKLATAGGNPCDSFNSNIAQAYSKYPGSKIERNGQTGLLTNLLGLSRKRRRSADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNF0</accession>
    <name>W3VNF0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNF0"/>
    <dbReference type="HOGENOM" id="CLU_265389_0_0_1"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834393" evidence="3">
        <location>
            <begin position="34"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1097" mass="118767" checksum="94AD58B01B7D00A1" modified="2014-03-19" version="1">MASSSRRWAVRSRALLTLLVAGCVISVLQSAHAEQAPFVPTPDSAAASPGTSDAPDPDYTPLQAYEQALRLLRSTIRTKPLRTKAGKGAPQSNAAEASSSSSSAGSPDAAASTSTSLRRWIQEIFDAAADSVSDASPAKIQSRIQGVSSSKGDGAHRWQGPPLGASQYESQWPSARTLTLWPDWETLPEGTAPISPSESVWESIMFGPFVGGSKAPSDLSLSESSSAHEEEQQADNPDRSQAVALLTRAGWGRERVDWDYEAYSPAARDASGLLRSTAAGETAPALADALWVLAEHSLWGTHGSRPNLARARACYQRLVDWGHDRSGLSASGNASAHARLAFLEGSGWESTVRGDWKPLSDQLGSWSTFSASPSADDVRAAWKRRRELFAQLKQDDGQRQAKAVLHYTLAANAGHAPSQMALGFRYKAGIGVAPSCWTALDLYEKAALDTYKRFQQGPPGGLTLPYTKIRVSDLDGGAYGPGASVASTGYAAMKPAVQAALNRQPGSARDPSALEDLLEYHVYLAEHGDVKSMLTIAQVYYHGSIYSSGDAAGAVRRDYRRALQWLLRVAKEVWPRKAGEVGRGGPTGYTAKPGDKGEDVQLKADDGLLAHAGTAAGMIGKMYLRGEGVKQDFARAWVWFSRGQTTGDLESYNGLGVMLRDGLGTPIDMATAVSYFEAAAKVRHSGANVNLAKIHMDMDDVDSAIKSLTLAVFGESRFEAVYLLARINAQMARKAHSNEQCRAALAGYKETAERGDWSTRISHKAEHAWRRGERQKALLSWALAGDMGYESAQNNVAYLLDRAHSRTRLLELHPTPDERHNFTDRLALVHWTRSAAQANVDAMVKMGDYYFHGIGTGNPGQPAYEKAAACYSAAADRGVSALAYWNLGWMYENGIGVVRQDFHLAKRYYDMAVETNEEAYLPVALSLVKLHIRALWAAAFRSDSSQSAISLLSSYTSTDRSNAAYTEADEHAAATQKQAEDNQRHIAQEQGGGYGDPNEPETWAARDDESDEDLDDMIESGLLILALGALAYLAYMRQNVQLQLQRERRQQADDQPPQPPNDADHGRAQAEPRAHQPNPWAPLGDEPNAAANLIAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNK5</accession>
    <name>W3VNK5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNK5"/>
    <dbReference type="HOGENOM" id="CLU_004131_0_2_1"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="232"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="696"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="915" mass="99961" checksum="20CA3EB90A94B49F" modified="2014-03-19" version="1">MAEARTDPQEGGSVIRAIPTSDVHRITSGQVVLDLQTAVKELIENALDASASNIAINFRDYGADSFEVIDNGFGIDPSNYASVALKHYTSKLASFSDLAHVRTFGFRGEALSSLCALASVTIHTATSQQAPMGTVLRLDRSGCVADDSGRAARQRGTTITIEGLFKSLPVRRKEFEKNLKREYAKAQNLLQAYALITKGVRWTTTNQPWGGRKTPQFSVNSSSADNYLAANVSALFGAKVAPTLMPLSLELTFSTARKGLAAVQKRGVQDDDEGDEEETADAASTVTVVGLISKPVYGSGRTSSDRQFFYINGRPWEAGRVSRAFNEVYKSFNSNHFPFIIADFRLPTDSYDVNVSPDKRTIFLHEESRLIEKVKQALEELFAPSRATFLVNGASHSLRSGGSSVAVQAKLAQYARSGAAASTQEMEREMSEEEQDELLPSQRSIATVQDLEYREDVAIASESASPNEVPVAEEAEDSETEAPLPHAPEVYAPPSVGEKRKEPTTTELPTKRRRSSQSSPEPETEEASPALDSPPRSSKGIRRNLRDFALPGSQVDALSPVSSAAESHSEQGETEVMEEDDLTVGALHEEASDVPSPEQSDAFDSPPSQPVLAEARAKTDEMEGGETVSLDLAILRNRTRQWREHKAASTLPARTTTLSGEEQLLQGAGVENADEEQVERTLSRVIHKQDFASMDVIGQFNLGFIIARRRTEPSGSADEMDDLFIVDQHASDEKYNFETLQLTTQIRSQKLICPRALELSASDELVAIEHQSTLLANGFEIAVSESGLPGTRVKLVAQPISKTTVFGVKDLEELLYLLRDMSAGTEATRAVRCSKARSMFASRACRKSVMIGTALNKARMGSILANMGTIEQPWNCPHGRPTMRHLACLQTLADMNPQGCTDDEPDWTEIQRCFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNN9</accession>
    <name>W3VNN9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02959</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNN9"/>
    <dbReference type="HOGENOM" id="CLU_361371_0_0_1"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="9">
        <location>
            <begin position="251"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="10">
        <location>
            <begin position="497"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="656" mass="73711" checksum="8510305AABE282A3" modified="2014-03-19" version="1">MTDTTAPVHGRGTAAEQGARLREAADREMGRVPHAGDRKAKTSRRSSRRISPQESPRSSHPPLVDDDKQRRSSKRNSRHHQAASEAAEAPFSEKTHVGTAAAQGAAFRRGEEAELPSPEQTREARERHLRAAYGETPKLGKGSPVKPHFYKMTGIDNIALLMEDDSYTTSCFSIYMFKTELDIETVENFFEVLAETYPKYRYVVDLDPKLSKKKEKETLRGMPGTSPPRGEFDAGRRTRYGKGLKAGSLLSPARWRFVPDFDIKENIKHIAQCPDGGDDVALNKLAGDFLGSHYDYSKPIWGALLVNGLNTSDGGRSALMIKIHHCFSDGQGMIQSYHAALGALEQGIGIRDIQRKVDSNTAQNKRPGQREDKPTAWGTIRHGFHLVRGLYFRSRKSFLYQEQRERVAGRRYCHSKGIDMNDIKMIRKAYGNEKLNLTLNDVALAILARALRIASERVDPSRRHKDKRVAIFVPISVRPKGDWSLSNATTGSIAWLRFEKEEHPDFEAQLSQVHREMGRIKRSYGPKILFKVFNAASKHRITYLPNYPLLRQFYYRAFREYHVATNVPGPPKPVRFGDHEAYSYHVLPPSSPGKSTMAIGMISYANDFSLAVSCDDVPEFAHLAEEICQAFQDAAEQIIEAANQKLASSKEASKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNQ3</accession>
    <name>W3VNQ3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNQ3"/>
    <dbReference type="HOGENOM" id="CLU_1321770_0_0_1"/>
    <dbReference type="OrthoDB" id="2553689at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833401" evidence="3">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="198" mass="20772" checksum="189E75989F9B3D6F" modified="2014-03-19" version="1">MRFMLPSLALLLVLVAAVAAQLQADSVSQPFERSLDDAPLLSERALLEARQAANTTASSTASAPESTASGSAPAGGDATITESTCSMVNHLAVNQQASWGNGFVNTCCGFAQGTQCWYRRQQDVSPQDECEIPSCQDLESEDKAKMIGFVPLNSTNGSGKYGNIFLSLGMLSPGMMNLPALGITTMVAASVLLLTTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNS0</accession>
    <name>W3VNS0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Toxin biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNS0"/>
    <dbReference type="HOGENOM" id="CLU_505392_0_0_1"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="183"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="531" mass="59164" checksum="B4B1CED27EB47227" modified="2014-03-19" version="1">MSSEDLRPADLLPSLEPPRAPVRPIIPTLAPRIAFTTLSQDLGSNKSQQWISTTHVYPAAWPRSHPRSAKSDIYNTGVPSSSSLGPLPSDPEAAKAEQRRRREADFAHWLDVCGGKDHGGQRNVMRTLRKGCLKSGHIQRITEARTANEAQLWMAVNRIVPAHLEDDVHKGAHAKDTRQGITLVVAHANGFHKEIFEPAFESLVKKLQTDELRGKYRIDEIWNFDCTHSGQAGSINRDLLGDTISWADHPRDMIKFLEHYLPDTPSHPSAEPAWLPTFLPSHKASSPNAKRRLVGMGHSFGGASLSFVLHARPRMLEGLMLVDPAIMHLDDEKAFKIDNLFEGIIPPIADFPLARGAIARKDTFDSLPDAKAYFESKPFFKVWDPRVLDLHLRFGLRPSAVPASRALVADDLHENDLKRTGLELNNTKWHEAAAFSSTWMGYIGRNGMLRTNHGAWVGMVNMEGGFNNFQLAAEIDKLDRGFSVTIEGNHLVAQEEPDALAGALAQIFEAQKDPSTLKEKKLTRQLQKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP16</accession>
    <name>W3VP16_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteophosphoglycan ppg4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP16"/>
    <dbReference type="HOGENOM" id="CLU_419319_0_0_1"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833267" evidence="2">
        <location>
            <begin position="23"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="671" mass="70046" checksum="F82E1532B8BF2ED0" modified="2014-03-19" version="1">MGLINLLLKSVILLLDLRDTYDALGSARLSEIGNEHKTVIVRNAQDGSRQAATRRRVGTSKRKAAVRSALTTILVWNLFHKLEAVCDRTISWFVPFYDSFKTLFLVWMLFTRSYGASILVYRFLAPLVRPYEHIIDAIIGLTLALSGWIASLLAPVTDSCTTLLHGIISAAPQSAQRRLSTAPLNPPLEAQADSVQSTSVSPKGKGKRKPPSPPPPSQTVSSRSKPAAPSRSAASQTARQTQLEPAAARRLVTKKASNADLAAKRRILQELPVPSHAFEPHVPNTTPVSQTSSISASVTGSQSAMVTAVKEEPIDTSVGLNTASSNGSPLAAMPLSTIAAEAKPEPPPTPPPTGLQNYAFIPGVTPQRNGPSALISPTPRFPGGFAFSFAASQASASTSSYPFQLQARLPATAQMAPLSLSSSQAPPLMLPLGSNSVATTHETVASAHDDRIVPPPGGAKVVRKTPSSGSLKSNTRTITASTVSKSTTVANGKKRSRAKATEDPDTDGPTRSDASKPSPRKRSKPAPGASAMRNASASGGPATARAKRAPTSTSVSSKDKAAVQASSAKDAAAKKATAAKGNGKSSAARANPDPVTTGDKPDSKSSGSPRKKSITVATTKSIPSTKPSRVVKKVSAAGKPAADKPAESTPPAEEPPPTRLTRSRTRQHLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPE6</accession>
    <name>W3VPE6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPE6"/>
    <dbReference type="HOGENOM" id="CLU_368457_0_0_1"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="756" mass="79846" checksum="2BF00E95CDE03C8E" modified="2014-03-19" version="1">MPSLTDLENFIEENLPRNLQELPHKVSLSVQEYYQILYEQLNKYGPPIPDLPSFPSFESFTGKVTELVSPIPPPPPVLPPPPPPTNLELIHAWTRRHRSSLSFAGGLIVVGLGTSYAYRAGYIALPYLGKKQVVGRGRKRQVRLKNGVRREAVIVLGADTPLGRSLALHFSSQGFVVLASVSSSAALAQFENLIPPSSRGYVKALIFDVAEPSSTLQPFVRALSAALSLRYPLTSAGDPYARPGENISIAGVVNALSFVAPEDDLASSRSMSSSTSNTSLGVPISKLSPSPSSELLERHVVSSLCVLGALVPMLRALPNRAEDSPDMEPATIVTLVSSPASRTALPRQAMYSVIAQSVAAGVQSLRRECEEDSFHSKTASNSKLPPNLSASTAGGASARRASSSRSQLKQRDVRVTMVEVNAGSVWGEPAATPSANLAEPSASTMSASSSLHSPSRPSFGRSPSSSLGSLWHHRSPTSAPVLNKVSDLLLSTKRRLRPSYTVGTYTFSAYWLTLSQVLLRVVPTSVVDFALALRRQLSLRRAGLVGRAEHAFLPWNWGKTSDAGKGGRRAGEQRPAGSGPGPGPASAAHSRASLLRSNADLKRPAAAGYEIRDSDVQSLPESERSSGAGSGIPSSVPSSAYGDNDGDADAYAGEESPYFGSTRQMHASHADLSASNSSLADAPTGGRTGGVPASFAREPWMGPPSSSGASSRLAHSPAVQQHSAHVSESEDRDGATDSPLGTSWVALGDSQHSHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPE9</accession>
    <name>W3VPE9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPE9"/>
    <dbReference type="HOGENOM" id="CLU_042989_0_0_1"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="186"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="395" mass="44365" checksum="5410F3D578DF7E24" modified="2014-03-19" version="1">MASSAKMDVDNADESYLEQAASSSSTPASLQSYYPKFRQLHERKLWYQLTLTIEDFLNHPDSQTPPIQIDLYDKFVKRFSSKINQLQLAAIGVKVARQYQEPAKALEFLEQLATKLDSPDSQDAYVYALMEAAHFKLLLGDADGTKAAMDKCGKILDGFDAVETAVHASYYRVCGDFYKAKAEYANYYKNSLLYLACVNVDVDLTDEARVQRAHDLSISALLGDTIYNFGELLLHPILASLGKSEQHSWLSELLFAFNAGDIGRFEALAPHLPKEAILAENLPFLRQKICLMALIESVFKRSADDRTIAFASIAAETKLPVDEVEHLVMKALSLKLIRGTLDQVEQLARITWVQPRVLDHGQIQALQARLKSWCTKVEEVSEYVKNQTPELFVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPG8</accession>
    <name>W3VPG8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPG8"/>
    <dbReference type="HOGENOM" id="CLU_027518_2_0_1"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="657" mass="70217" checksum="01BDF5BDBF83EBAF" modified="2014-03-19" version="1">MSLEDKIEAVDAKEMSTWAQQHATYIAGGMAVQSGLGGAATAEQASNPACRAFDEAALFPPASSSSASRLLGFLSTVSRRMRILAPWLQPAFEFSFNPGWESTAGWPVCSFAPAIRLMLKQSIGVPLTFVSALAHRDGTAAISLGHWIADARCGTGSPMRYSIVMYLTIPAPVGAVWVRSGRLRCQSPLAARLSIPLHSPTILNVGPIFLLSTHWHRSLFEESPSPPHVLQTPIMNALQTHFWAVREYLSPVLRESKFKEHGRITPDEFVAAGDFLSYKFPTWQWCAGSPSKARDYLPKDKQFLISCGVPSLRRVSQIEKGVGVGVKDDDERLMSFADGDDGADDDQWVATHFDANKSSSSGVADMIDIPDIGEDQSAPEHQLTEGQEDDLAARVAGISVGSQNTMPPSTSAGEIGDIPDIPDIPDMEDEADDLAGGVEEEDDPATAAVSAAGANTSAGDNGKLLSVRKYDCIITYDKYYQTPRMWLVGYDEHGVPLKPAQIFEDVSSDYAQKTVTIEPFPHGHAGPDSSASSSSASAAGVATASIHPCKHASVMKKVIERMNASVIEEQRKAAAAAGGAGAPAPDKKKKKAWSVASAVKRVTGSTADEAPATAQSEGAEAAEEDVQGLRVDQYMIIFLKFMASIVPAIEIDATQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPH9</accession>
    <name>W3VPH9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPH9"/>
    <dbReference type="HOGENOM" id="CLU_004624_8_2_1"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000100">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="101"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="542" mass="60338" checksum="69F58A4EFED19E70" modified="2014-03-19" version="1">MKKFIGKVQQGMNKLDQDRRAGKAMTSAQTTFDALPPTSVDAPPTRRDIYRHRKQRGVNLGSWFSLEAWLTPSLFQKARDPKASELDVVAGMDPNEARAMLENHWDNFINDGDLQWMVDHGINTVRIPVGYFHFLAGHPNESVRALIKDTDYERYAPIYAGTFSRIQRAIEFTASRNVGVLVDLHGAPGGQNADAHCGVSDGKAALWDSPANQQKTIEILKAMASEYARFENVVGLELINEPKNSGSLSSFYDQAITQVRSVSPEVAALPLYIGDAWDTNYYTGFVGQHASASNFLVTDHHLYRCFTAQDLATRVEDFARKLNPGTSPLPTNSDGAGETAVWLKDMSNRCGGSLVVGEWSAALNPASLQYLSTEEQQRAAKAEYAFNEWKSFDKFCAGYFFWTLKKEGAPDTGWGFYSAVERGVLPQHLDPHRGQRKSVQELEAARQAAQDAALASHANYWDQQSGGPYEHWRFSDGYSLAWTDSVEFLKANESNEIGFTGQWQKTRTAAHAQAKGQGSTMIWEFEHGYNQGLAGFKSALYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPL0</accession>
    <name>W3VPL0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPL0"/>
    <dbReference type="HOGENOM" id="CLU_308864_0_0_1"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="898"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="322"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="901"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1125" mass="121535" checksum="95BED2E6F97FC8F6" modified="2014-03-19" version="1">MWEGSAAHPRCFGRPSLSSIGTGAAQLAVLASDPADFDFACPASKHRPSPATGSTSAAPTGATRPVDSARPLSPPDITVSRLVKACDRWPELSKAQWVGVWKAAAWNWVLVSRQLAARVQQGKRPHHTSGQIFPPASAVRQRATQPRYAILAFSLDPILAASTPPPRPPSTTIRFFIDSVDSMDEELVDDRPRIRNSQACLECRKAKIKCNGKRKDAQNCSRCEAKGLDCSWTASRRGKKPGTKNLATRAREQSEALQRQLEHQLHTKVDRSSPPAYDSQPSLYRQAWDSASQPRASTSYPPHPAQTEQRLMHRHGSDASNHQSPQSTATASSSSGSHLSSSVPTAMSSNGHNGSHTSNFSGNSSRRTSKYHDGLLIRESRMPPSSTNPLLCLSEAALGKRCTESDSEEDELAADNEPAEADAQLLGDQKDGKKRSALHPYVDDLANEEDDAQAKSARDIASMLESSGWTRSCLAHAACERASYFSGASASASWDTRRCDPLEQGIVTMDEARRLFQLFMDTVHEQFCILDPVIHNVATIKESSNFLFSVILAIATSIDRSPRSIRQFELLRKLVDSLVVEVLSRNVKSVEVVKGLIVWPMWAHLTPLMAEDRAWLLIGTAARMAKELDLAMRDDVSQEDELARRHARDRSRTWALAAIMERSFSSFSGQRPNTTLDVDWGTLNDWLKSPISLDGDIQIVAFLHLRRIEEIMRTRIFSQSYYEVGSIESIRVSANVLLEAWSEAWCEHPALDKHPLTSTIMRIIGLHVRVLINTHAIRESDRRRAICESSNMRILRVCGESVKAARECCVMLLKDACRLALDNLQGQAHTVSRIVAAMLGWSGVHLLKNGPIDTRGLVVQLGLLLAGDPLDSAHSRSFARFYGRFILSLSAELVERDRAEKHRRKRQRLRGSSHMSTGSSGVGIASPRGEASNMARGNTAGGAVASHDAGKAVVAPGLGTSVPAAAMSDMAFAFESAAQSGLQTPGMMGRPAMVSHPGAAASSMSPSVSNAAGQSHAYMPAAGTGAAGSTNNMAGMLSGGSGAGGTSPFSSAYRSATVPSSMASNGASGLDPVTSTWLGTDDLLDQYMQSILPIFNDFDHATNNTMMNSIGGGGGVGVPISEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPN6</accession>
    <name>W3VPN6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01817</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPN6"/>
    <dbReference type="HOGENOM" id="CLU_485809_0_0_1"/>
    <dbReference type="OrthoDB" id="2548315at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="239"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="561" mass="62543" checksum="4789F7954F15C7DD" modified="2014-03-19" version="1">MSNAYYAQQPARRAAYDDPLAAPYASQSRPNFTHMHDDMDGADYHHFHGVASHAPQPYHDPYATLTPGDDRLRPEWDEARYSKDLHSDDAHDATLRPTHYTLGKDDDTGRLGYGRGHRIEATDGLLPDTPPDPSRLNAEQREIMKRFPADLDAPGGGKSGVQAAIDLLKDWKSWFQLKYLHWWIMLVVVIAIVALTTIYHRQIVDWLTPISKKVTTVAWGWIIPVAILFIISFPPLFGHEIVLILVGLVYGIWIGFGIASLGTLLGEIGNFYAFKHCLRSMAASYERKNIHYACMAEMVRDGGFWVMFLARLSAIPGHFTTAVFATVGMNIFVFTLAAVLALPKQLLIVYLGVAIKNSGNGTEDTKSKIIKYVVLAISFVITVWTAYWLYQKMEKVRPGVSARLRQKRYELLLQARTPGTEGYSGEHHSYPPRMGGAYRQPFGVDEMYNGHPADVSSESYDPPPPTHIAQGRQPIPRDARSQAAQAVAVQASQAAETRQFHRPMRVRSPHDEAAPLTSSTGEWASSSSLASPVDAPPPDYTTHLAAAHIVDPTVQRYHLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPR4</accession>
    <name>W3VPR4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02475</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPR4"/>
    <dbReference type="HOGENOM" id="CLU_284424_0_0_1"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1051" mass="113125" checksum="BB238350D2B2D1A5" modified="2014-03-19" version="1">MTVDTQQGASGPANGVESTAGAASSPSTPSRHGRARHARTNASLTSSSGITSTDAPFSMDALPRRTSVPNDATRIFQTTGLDPFGTEPDTLFRSLPAKEVEAYERAVRSIAVTKQQELRALVGQRYQDLLGTANTIIDMVRSSQQLTERLEHLSNGFQLAADTKEKRDTPSKLARRKSFLPTQHPTGLKDTEASDLHQEAVYVLGASLRLIMDVPEYVWKSIEKGKTLQASWAFLLAKAAWNDLTDASSRHRSQSALLPDAEMGIASVPEAVAMLKVNVRDTFPFIEKQWQSMQPMRKQIIHRALLLLSDIDIESAAVADQLAALVLIDGTRLEQALQLLLSHRLTAMRRLLQRRRKGKKSSSHNKDDRRAVAASTRSTDASESDLAGDRVAKASHTITELTTLFVRSLQHVFQLSVLPLRSDDSSEAKPWLLSLLNAITDTDHSAPAAKLVSSPTSERASLMPQSADDRTPRQNAAAMRALRRKSSHGLPPSSTDPRLDSDEGIDLPQPPQPRAVRVSTADVIQTLPSSRVLVRLLPMSLQEYVPPLDLASRGMPTPSQVMDDVSSWSAKAREIIVGASNHAGTDSLPSLLAELSDVHELAKVRRSLRLAMQRARRIVSRKLGAGDETEDKIRQSALAKVHTEMQNFEADIASALQARLLQLLQQKLSGAAQALLKEAKATITSLERDAASLGNGADAGAAAVEMPLDALFHPVEAQNASSIRSAPLDADNPSNPIRSSRSYISALQDDLRGRSNKVESLASLYETPLSAMSRELKIYRAELEGDERFADASAAIQASFDSLIASSRSDIETGLSDLLDRSDGIAIGAEDGLPRATSLTMQLIAVLATAHAQQDQSASRALRPPVTKMLERHWRPRLERSIPGVFTRPSGTGERTVSAGSSFSTSMLQILALLSESIVELGPALAGPELAGLVRQILEGVATSRAAVSTAADHQAAADAASLTSLLQCEPGALAELIGADTRLHRVRLALSPLLLALAASAPASQLEAASVQSVVVLARADPASAIGDVKPILSVPRNRKLERFSPLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPV6</accession>
    <name>W3VPV6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_01893</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001871_1_0_1"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="1028"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="358"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="560"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="684"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="767"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1276"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1370"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="709"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="729"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1276"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1374"/>
            <end position="1389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS63594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1441" mass="155406" checksum="35586657986FE669" modified="2014-03-19" version="1">MPVIRDPGDPNYDDLERLPLSLSMDLDFRNKPSQPFRWVDDDRHSDDGMLTTDNSGPATPAAATTRSTTPHIVAYCGTEPKNVAITSGVRAWTKHQAYGASDALIKYATASPLLPQQIAEMVSNLSVIARVSLKAAAFFIEIILEAARDATGLTLGITRRALIGAIGTARAVHSITSGEAWDAKATGRSLTAPHPSFLSILDKYTAVGIYLVHHTFTLAELFTMGGFSLVQTGLTAGIAAADESVRTLDGIFGSNETSRALASFVTLVRGEVNDDPRFANDSYVSILAKLTKAVTAFAVLQNSTYKRSAKSMKMRVVYDCTILGEVEAKSWRSLMVGSGNFKRAQPAALLPSPAADDFESLSLQSPPRRSASLLTPNHHLAPSTSSTNLPTSRSRGYLGDGLCLTDVGPAVPHRSWGSGWSQSPQDQADNMQDDASLIEDLNFLVGTDGAEESPESSITDDQLPDDLRSKLQAYSDDQLRNGVVLRDGQRDMPKQLLRRIRKTDSVTGNRETVYEITTEMIETVETITTVEHMGSDPPSAYGSTGAPLDSSAARVHDQALSSHPAGTLRRDVTSSKSGIETHSTFDGGHETKLEEDEEWCEIRTTDSRTPHAPTQLVHANTHNARTDDEAGAMSLAIPEAPNGAAANAALIHGKPRSDTSKMPVVLKTMTKKLIQKRKTLRRIELGDTRGDADASPDAAFPVGSETADLVSPTPVSPVLSSVTATVPRPAKDKSSRGARRDAHADLASAKGADLGRGLNKVLKRAKHQLMGAQPGEARSSSRHLEPPASVALGPPPQTHTSSRSHTVPVAEATPLSSPSKSKRALPSVPPSSSHAKVRKGNDIDAKSDIGMARGAGKELPTIPHRGASQRSLFTPEPVRASMPSTPQGSLREPNRRRSRAPSVTSIRSFASRSHVSSVAAAGNSGEDGVDGAAFPQAHLVENLRRFMRYSSAAYGQNFMRILGIGSLDYFFPDTSKHHANVWAFAHHVGIPVDAILLNSFSEAQPLFTEQMSPLVNYVAVDDAAKAVVLTCRGTMGLSDILTDLTATFETIAVEGGRSDRHYQVHSGMLASTRRLCNENSTVMQTLRRALEENPDYGLVITGHSLGGGVAALAAVELSCPADLFRQQSLRQRAKAGRIVPHPRIYTPFVTSFDSGLPAGRPIHAYAYGVPAVASPDLSAHCKGLVTSVIHGHDFIPTLSLGMVRDFKNIAHALSEESESDVAREIVTRVLGTYRQRSALRARAAAVPEHLAALEAPRPQEAPLSERDVQLSRQELLDGKTRNIAKDDNYQDPNLKEDDLDPFSYSSGGGRVHEGSDPADPELADWLWSLIKTIRADMDSLKLYPPGDVYCIESFAVFVTPRMQPDSEVVVDRSQAQQPGQQGQAGGNRPQAHRVILRYCQDVQKRFSEPVFAKSMMRDHIPTNYELCLSLLHECIVESSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPW7</accession>
    <name>W3VPW7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Actin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPW7"/>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000188">
        <property type="entry name" value="Actin like 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000008">
        <property type="entry name" value="alpha-centractin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42210" checksum="B3C200E5FAAD05C4" modified="2014-03-19" version="1">MPGNEFDDVLTNQPVVIDNGSGSIKAGFAGQDAPKCFFPSFVGRPKHPRVMAGAIEGDLFIGRKAQELRGLLKIKYPMEHGIVTDWEDMERIWNHVYSDELETLSEEHPVLLTEAPLNPRSNRDMAAQIFFETFNVPALFTSIQAVLSLYSSGRTTGIVLDSGDGVTHAVPVYEGFSMPNAIRRVDVAGRDVTENLQTHLRKAGYHLHTSAEKELVRVIKEKCCYVALNPSKEEKDIKEHEEFKLPDGNTLRLGAERFRAPEILFNPELVGQEFPGVHQVVVDSIGRTDLDLRKNLFANIVLSGGTTLTKGFGDRMLAEVKRLAVREMKIKIFAPPERKYATWIGGSILAGLSTFKRMWVSAEEYNEDPDIIHKKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ04</accession>
    <name>W3VQ04_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ04"/>
    <dbReference type="HOGENOM" id="CLU_035172_1_0_1"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF30">
        <property type="entry name" value="SERUM PARAOXONASE_ARYLESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="496" mass="53883" checksum="D588F6DCE858D796" modified="2014-03-19" version="1">MPFAYLRKQRESASLHGNPAPRGVSLGKAVRIALVAVVLVPLALWLPWLHSALGPSGLPDHWVRSSPGLESECGTVTHDGAALLYCEDIEAIPGTSTVLVSCDANRPRWNTVMGPLTDPGPRGTLYAYSLNGSKQAVPVELTGYPREKDFHPLGMSMFTGSKGTRLFVVNHARDRSTVEVFDLVLEKEGWVAKWVRDVVHVVATHTPNSIHALSSTSFVVTNDHLFARRPGPLAHTLALLHHLFLGPYDECRSDVLTWTLLQVAKVLTHRGVAARLAQIETLLGLPLGWVSFVDLTTDVDARILARGIPFANGITLTPDNKLAVAATTYPGIYFYSYSPPHSSSSPLHLHSKLHLPFRVDNLALSVPPRSAGDDAWGGRVLLATGHPAPLKLMAMSRNVTNRAPSWSVAITPFSGADEWEDKAAPLPAHRFVLSHNPAWSVRTLFQSNASPATPDRQSLASSASTFYRPYDHHPHAGTLLVSGLYDSLLQCSNVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQF6</accession>
    <name>W3VQF6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="13">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02006</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQF6"/>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="751"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="848"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="892"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="960"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="997"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1058"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1091"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="14">
        <location>
            <begin position="550"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122029" checksum="DB12A711653628E6" modified="2014-03-19" version="1">MAGPTSTSAGAQPDVADASTTASHIQSAGSLRIRKLSKVSPARFLLLSLLFHVVYISSIFDIYFTSPVVHPEPRFSVRDTLAPGHVRESLEAPAKRLVLMVGDGLRADTLFKQHSSELLPPWSAAKEADYDLDDTSGLWASFAQDPFSAPYPYQLALQENRSIPCAHDQSCGHPDQAFAAPFLRSVSRDRGAWGISHTRVPTESRPGHVAMIAGMYEDVSAVTKGWKLNPIAFDSILNQSTHSFAFGSPDIVPMFAVGAAADRVDMWTYNEEDEDFTKDATHLDLWVLDHFKKLLNDGKNNPELRRKLEHPGTVFFLHLLGLDTTGHFYRPISPEYVGNTIVVDAIAREVEKLIDDFFGNDGRTAYIFTADHGMSLKGNHGDGDPDNTRTPFVAWGAGVRRPQVATAQQIRQAKAEQERDPYFSNWHLEDISRVDLAQADITPLMATLLGVPVPANSEGRLRLDLLNLSAEHKARALLANAQQVLETYRVKHASRARRMVRYVPFAPLALVQDETLPGEEKIDHILISIEEGDFHEAMLLSNALIDEAIEGARYLQTYDWLLLCSVVTIGYLGSIVYSFAFLLRNYILSDQEIAATAPVPKPGGKSHTPLLKILVAPVSGAVFALFAAQEMPFSYYLYAALAFLFWGRVLDDLPLFAAAYRCISGSQTGFSIVAILLKVLASLAMLELMAVGYLRRETWFVGFILIGFAWPALGMNADFKSENEGLLIVWGFSCLLNGLFTIGNVNKEESITLLMLSAAVFLTAGSVIISRPKLFFPGACTSGEKESSGSDGERATSDKAREADALHLGHTLQTLKVQLVVLVVTAITTAVSARSLRLKQGLPLVTQSLAWICLATCLVFPFAYGFRSPVAIQAGSEDAAISLVRQPSSQRLAVVVFAFAPVFVLLSLRDEVLFFGSFITTLLVWAKLEGALRETRRDPTMPAEQSDKRYLQISELRVSLFYLFFLHIGFFGTGNVASISSFYLSPVYRLVPVFNPFLMATLLLLKILVPFVILNAIFSLLATTPSITVSPPGSKAPDRGLKLLGDTAPGGLGLDSGLSLVFGAGIAADVLALNFLFAVKSEGSWLEIGQTITHFVMANLLQIFMLALAAASSAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR00</accession>
    <name>W3VR00_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR00"/>
    <dbReference type="HOGENOM" id="CLU_2016227_0_0_1"/>
    <dbReference type="OrthoDB" id="2552901at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="123" mass="13336" checksum="0BB8707186C09C0B" modified="2014-03-19" version="1">MAGGLPQRPSQPNPPSASSPIKPELAPLAPRSVEELQTEITEAELVLSARLETHNAARAAKGLPPQEAEQIVEQYIKLLTQYNHVKDATQLVFDKIAELQQLPSGDIHARYGASDEFTTSNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR42</accession>
    <name>W3VR42_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR42"/>
    <dbReference type="HOGENOM" id="CLU_013899_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1122" mass="124083" checksum="0616F7DE5FFAA54F" modified="2014-03-19" version="1">MAGACAVLCRQPQAHPIVLEPDSLSGLISLVASPPLRQRHQLCLGLSLPSLDAPVHRPAGQLRVEALHTLENPHYLPKPHSRAPQPSKPTIAASSPAKWAADGGMRRRGFFEALPILQGPHFFQSPENLLLAASTRHSFRSTRRYRKEQQHDDCKAGPLTGKSPKQAASFSPARSDAKDCECKGRWLAPVAIMLPFLLPSASLARATPQLARQLQSIIKRRHIGPCLRCASNVAGRASRAGSEQEDLGESDDPPHVHSHRGRQTPFSHFFDRRVPVTPPIQEPRFGDSKASYDITAASRQATTALRRAVSSGSSTEIIDSYDNLVRTYHKHLQDVTSSSSKLLAPSEVGFPLRKDDIQNAIETLLLNARKQGPIPPQIAEACRRMFQDLSRLFAFKIAANDLHRQLYCVSRSTDVDQVSAFRELRESYPDWKVAPFRWGMIISPLARRACYDQAIDVWQEMMEAGVQSDVRLRETMVNLCLESQDTPARARLEGLAQGADETAFHTCIVVVEGLCNFAARVLEVDEELLLRLRTHASHLRGLLESRAPDEACTAARAALLRFEAVDAGLTQAPETASRAHEPQSPDQRAIEELLLGLHGDELNSVQSSDEAVELLDRVLAATDKGRTIHPDDQCYHLLMLGLLNTRGSDIHAIPAEDAEDGATQSRALPSPNQVREAQLLYDHARAIGASPSSQLVVPLLRACCEAFIPSISAAIKLVSDMLDHRAVRKATNEVPSRNTDRVGMDVIGPVLNACVRTRDVAAARGLLSRLQSARIAIDVDDKALLIRPLVGMASSWSEAFEIYRALSRLPISSTCESTGLDTRGYTELRRSLFGLCFTEDRGRGERVMLAAPPEDLLGVLQDMRADGYPPTCAVYTAVLDYYSKTQPPSAAGVAATHAMIKWDEKLEPDLPLVNALMNAYNRIDEPTIVLAIWESLLATRQEIDAVTLTVFFDTAGRHGLLTLARKVVGTVQRAEHEAKERGAKRRTPMNKGAWDAWLECLARCGRLEEAIEVAFGEMRTTLLRQAIEWHDLDEDGDAAGTVAEILVRSMQAPVRDRNGHIVGPDAKTFGTLLKFAARERDRRQRRRTGRESPIWHTLRTRLREELSWLYPQVRHIGESTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRC6</accession>
    <name>W3VRC6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRC6"/>
    <dbReference type="HOGENOM" id="CLU_045832_1_0_1"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="26"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="345" mass="36628" checksum="1A1B6249CD22A2FB" modified="2014-03-19" version="1">MAGGNFELVALGNPLLDMQIRNGEAMLEKYGLKPNDAVLADDKQLAIYQDIVDNYDVTYVAGGAAQNAARCAQYVLPPNSTAYLGCVGKDDLAKQLQAANDKEGLKSIYQFSDDAPTGSCAVVITGHNRSLCTNLGAAEKFAKSHLETAEAQQAIKNAKIFYLGGFFLTHGVESALVLANEAKARDVSFTMNLSAPFIPQFFTAQVDQVVPFADVIFGNETEAEAWAQAHNLETKDLKQIAQAIADCDAATIKAEKRVVIITNGSQPTILAKRGESQQFVHETPKINPADIVDTNGAGDAFAGGVVGALVLGKSIDEAINVGHKLGGMCIGQVGPILKFPKENVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRD5</accession>
    <name>W3VRD5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRD5"/>
    <dbReference type="HOGENOM" id="CLU_012629_0_0_1"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="356"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="356"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="820"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="939" mass="99613" checksum="BEC7866B3E1D6876" modified="2014-03-19" version="1">MSSRIEKGGARFKPSIVPRRSAAGTPTANSTATPASSTAPSPSGSQQQSTSTSAAATPPASSAAPARKAQLITPRRNVPVTPSQTDAASGPSRLHTTQKSQSYAFTAPSSVIAKTQSSPATRTSITAGQPSTSTAAGTGAKPVFRRPSVSKPRPGSRTSLTPAPASSLPSSIKVIPSSDRAAPPIDEEAAAEATEATTSSARSNAPPSIGGSRTSRRDDASAIHAGVSRDAALVQSDSHQVAVDKASQPDPIQAPAPPTRARSSTATSAPPKTPLKESASQADNTQQISESVAPSANAKGKAREVVDNSGTAVGQTAPSQNDTQDKAELAAARRRTTADRLQKRRLKRKERASGKPSRPLSAYLLYVNSVRADRQLQNPQMSLTALTSAIAAEWRELQPELRGRWETEAALLRQRYDSELEAWKQAHPEGVQLGPEDESDMETTSELDDDGAPIRRKKRRVTAARQPHTVSDDEEEYRKQLYQEGPQLTASRIDPNDVMMADISTAEYKKGRAGPRTFEAERVYNRLVTERRAAARSAMLGGHVLGDKLDAASPSPAPPSRVLRATNSAPVDATQEVLEGEEEEVVGDRTEDDEDEDADSDDDSDDAASARARRKREASVAATDVSFRENRFAVQTRIVDGKIVLDETSLFANFGNEEDRDNMEVVDEREGDRFVNAATYSRKLGRNRKWTADETAKFYRALQQWGTDFEMIARLFPGRDRVMVKKKFNVEERSNGKLVDEALRNSIPVNLEAYAAAIGVDLSGPPPEIKADIQDIASLAVPEGVIKKREGTAPISGKKGGRSDAEDDAYDDDGYEYEEVVEVDDDGNEQVIRRRLGKKPGSRGAGRKRRNSARKNSVSTPAPPAASAGGAGAGAGAGAGAEADGDADAAAGGAAGAGRSGGPPSIGSRKSTRTTRPRAASTREAPGDGNEVEQIVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRQ3</accession>
    <name>W3VRQ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRQ3"/>
    <dbReference type="HOGENOM" id="CLU_002562_1_0_1"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1187"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1206"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1229"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1260" mass="139071" checksum="24645B3CC9EF8150" modified="2014-03-19" version="1">MVTATTTATEASTSVAASTRRGALARLSLKGKLYQKGSSTDALLKRVRQVRTELSEMDQDAVDVNSLKDVCRELVTPALMLHKDKAVKAHVACCLADMLRLFAPNAPFTPAELRDIFQFFLHQLTMPAAGLSKPTGPQYAEYFYLLESLSNVKSVVLVCDLANADELMSDYFKGFLELARPDMSKNVEICIADVLVQLIDECVTLPSEVLELLLANFTPKAVKHNPAAHRLAVEVCSNTKDRLQKYVAQYFNEVINSASQEDDQDERIESLQTAHALIVQINRVVPSLLLNVIPQLEEELRAEDAQLRVLATKVLAQMFAEKPSSVAAAETGDLARRYAGTWRAWLGRANDKSVSLRVVWAESTKPLLVHHPELRHDLTPILQHKLLENDERVRAATAKMLGSLDYETALHHVDKSVLLTLADRCKDKKTLVRREALGAVGKLFDMAVSEIDNNDAAAIQQFAWIPQEVFKCIYAGQHDLELLVAATVEKYILPVPANADDDEAAWTNRLLLVMKYLEPDATKAMLRLSNLILVRPALLDRFLDCCEQYNGGEVAADKDSAVVKTAMADRIRRCAGLFADPERAKTDLHAFAKLNDARIVRLIRTCFDPQTDLKTAVKSRNDALRRIENANAAMLDTLTVFIRSGSYLILNRSSVPTLIRKLSAPPSARGKQAASQSQSQSSEGVADVETHRASAHELLEFMAKRCPAMLGMHVPELCRALFDEANAVLVQTCVQALAAVAQWNAAKVQLDKKAVERLAKLVLKGTPLQAKYAAKLLAIVATGGARGGRKAVGQKPGAPGASVSSSAAFGVLEEVLDSLAKHLGGAKAERQVAILQSLAQLFKHAPDASENVSSTVVRTILSEILLKPLAGKGKAYASGEDWVDDSAVDHELRAKLLALHVLTRRCEAFAETDSAADLAKPIFRLLWAVVGAGEAKALGTPAAAKSRMRLQAAVCVLKLARHPAYDACIGREYLDLAFTVQDESFNVRSRVLHKLLSYLKTRRIDSRFLAMAFLAAYDPEDENRNMVLRYCQGHRSLPAEQRLKYLDVALPRLLHLLAHHPDFARDSAEDIRQFVRYLDFFLDALASASNVSLFYYLATRVKGVRDAESQGASENLYALSELAQLVIKRRAASHGWTIESYPAKITLPSDIFKPLPSREVQREIYDRQFLPADLVRQLSEVKHKTKAAAAGGAGAKWSMANIRTAPQKRKTPQKGAKPKKRRSAKRDDDDQDDEDDDEEGEDEEQEQDDGDESSELSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRU5</accession>
    <name>W3VRU5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRU5"/>
    <dbReference type="HOGENOM" id="CLU_2455670_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="89" mass="9320" checksum="84E0CCADA7147F1A" modified="2014-03-19" version="1">MSSSDQAIFPSALLFDSSKDSGHTHNGGIVTPLAATASTAPPSAYQLRFLAAKTRKALDISVQCYIPDQSGACLHLSDSPPHPAPNHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSF5</accession>
    <name>W3VSF5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="8">2.4.2.19</ecNumber>
            <ecNumber evidence="9">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PaG_00940</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="8"/>
    <dbReference type="EC" id="5.6.2.2" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSF5"/>
    <dbReference type="HOGENOM" id="CLU_022830_0_0_1"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="18 21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16 21" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="23">
        <location>
            <begin position="136"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="22">
        <location>
            <begin position="215"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="24">
        <location>
            <begin position="461"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="25">
        <location>
            <begin position="576"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="21">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ETS64479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="730" mass="79073" checksum="7B922D729D52CC5B" modified="2014-03-19" version="1">MLDARCSMLDREVRADASQADQQRSAEAGRIAVDRRSGQLAAPTCLAQLYLAARLYLCLGPCRDQHSPSNPETALEALRAKPAPHQAIPSMSASTAKPAGVYAHLLPPSWKGKIAEWLQEDCPSFDWGGFVVGEDTKRATLFCKSEGCLAGVPFFDEVFRQLDCTVTWHYNEGDWLGSPDGSAVKIAVATVTGASRKILLGERVALNTLARCSGIATASARFLAKARNAGYTGIVAGTRKTTPGFRDVEKYGMLVGGVDMHRYDLSSMVMLKDNHIWSTGSVTNAVHAARSACGFSLKIDVEVQSYAEAVEAITAGADVVMLDNMDGDTLISNATRLKAEFAGKHKFLLESSGGIDIDNVQQGGHVDNAIDIISTSSIHQSTKHVDFSLKIDPERAPVLARIDALVADLLHQLAGQLDAVNPAPLRLSTTRLAEPSEHDDSLAQRKVRPVMFPTRASSGVRRFAQYVRVLEVVQANLLAGRTMTKRDVYYSCSEVFDTQRASDLVVERLAQLLGCTRGALGIVASTRGLVSGSMHLRSPDGRAVHSVRGETQRIPADMSAAWSVHPTCPEDCRGHVVLVVEKACVFQRLLDLQLGSDLIVVTACGYADAATLELVRLLAAAPCPAGVRVCGLFDGDPYGVDIHMHYCAATPIQWLGVDADEFDLAPQTHTALRADERTKAMRLLRHPSPVRETHRRRLTSTLLDGYKVQIDAAYTWTGGLGAYLQHKLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT00</accession>
    <name>W3VT00_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component CSL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT00"/>
    <dbReference type="HOGENOM" id="CLU_067135_0_0_1"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05791">
        <property type="entry name" value="S1_CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000223">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="5">
        <location>
            <begin position="91"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="257" mass="26965" checksum="0AA86B9B2C708DF4" modified="2014-03-19" version="1">MVASTTSASSSRLLLPGQPLSSTLSTKPGQPQLELGLGTYSRGDYVLSSLVGYETRTPSTSASAPSSSSRSQVPKTETVSISGVENRFVVPRPDSTVIARVTRVTPRQAYLSILIVDGQPCGSSSSTSSTFVQSGLGNHAAGEGEGIDFQGVVRSQDVRSTEKDKVKLADCFRPGDIVRATVISLGDARSYYLSTAANHLGVIYALSATSAGESSNAHQGPGWNIAGNQMVPISWNQMIDPITGIVENRKCAKPDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT12</accession>
    <name>W3VT12_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004736_0_0_1"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="1322"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="421"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="744"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="879"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1063"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1292"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1364"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1446"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="744"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="887"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1070"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1372"/>
            <end position="1386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1491" mass="153662" checksum="765C4D8E0A6E8EC8" modified="2014-03-19" version="1">MSIGSQEASSQGIQVDPGAAAAGSKPSASSSSSSDLAPRTLTPPPKSAQQAVQAAPSQQQSQQQPQQSSPSQSISQNVATQPSSSAPAQAKVASSSTPAPASQPPPRPPPPASAVSLHDAAAKAAAAAANKAAAGGSALTDSDSKQTATPAKTQSTSSQSGLDNKGEANGSTKKTAKPKAPKPPGQTKPKQKRRANQASTQDELVYRPTSSTVGGTIGAAPDLVIPAMLTAAGGGRKALPELVLPFQLPYVDVRPDFPVLDNASVQSAMAMGASETSSPDTGSDSDDYSVLSDESDLDSETEESRRQARRRRREPATIEESLVLLQSLRQSRLSHLSSLLTPFSQRVKSGMIYPNVLPLSLLHGLNPREPHVLIQLGRADIHVGPHVFMKTKFWEVRPDYEMPPIMDPLARMRAHGSFGGPPDYVRLSASQPLPHHMSQPPPPQLPSPRAAPVIPAPSVPLARPPTSSAKPLPARPPQTSGPSPAPSTASTSVAAPPTSSVQAVIKPIAPAAPVVTSTPTLPATPVASSASARSSLPSKPPVSTSPSASASSGTTTAPAASPALASTLPAKPTAPGPSTTSVAPATSAGTSTAASSTPASPAIAAKPTVPSVAAKAVPSTSNAGAATSAAAETKPASVTSASVAATPKPIALPVSLPRPPMTTPSLPRPPSINQAHMASNALASSTAASGAATLATAPTASSQAPAVTGTQAKPASAIAPVLPRAADNTASSSAGPATSATAAAPAASASTTPAAPSATSTSAPSSQAAAAGKPADAPTATTSTQPPPRPAGVPPPPAIDAVLVSRVNATAALNPELQELLHIAASGKANPNQLKALGVWIQAITAQLRQDEARNAAAANKAGAAGSSASNGASAANAAAGKKTKKAKVDEAAKASKKQAKIEEREAKKQAKAEAKAKAQADKQMAQKQQKEKQPKQPKQQQQQQSTVPPVSNKLRHPPPGWPTDGPPKPPVIIVEFRENPSMRFILPLWKCLVERTEGIERPSIPKVKKERRSFFDNDSEDEESQRIEPELKLSFFAPSLGSDAADGSGLRELEEELKRKAAEEARLNPSKTTPPASQAANSTASPEAQAPAEDKNGETTPAASGKKKKGSGSTGGKKSSSKAIKQETSDMNGMTDLNLSKKHEVYPLTWSIKGGVTESLWEAFGRVPGTMTCQPVKREPEIELEPDVAEFLVPEIRYHLLDLPMEEIKFQKETTDSFVDLYSQMPDRRFILPRVAPALLPQGLEDHLQDRFAVRPQCVSGRPMVKRKAGAREDDVSFSYEGIGLTVIGPDGIQTEAGATPAKPPKRKRHVATHNPDGSIKSCGACGKTKTPMWRRGPKGPSQLCNACGARWKAGRLVVPEVAPPPIIESEESKSKDEEARKEDEVQASMHGSNALVIPQSSSGEDGSFTVMAASGLVGPAAFGDHSGAGMYSLGSDSKTGMGFGSSHLARGSASPSPFIRSPVPEDEVMPASVDPSMLSGSMRLPSNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT19</accession>
    <name>W3VT19_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1764-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT19"/>
    <dbReference type="HOGENOM" id="CLU_103523_1_0_1"/>
    <dbReference type="OrthoDB" id="20835at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066:SF1">
        <property type="entry name" value="DUF1764 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066">
        <property type="entry name" value="GROWTH FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="20622" checksum="1F84DCBBF752DA2B" modified="2014-03-19" version="1">MGKSKTPVAASGKAAVASEIDDIFSSTTTPKSSSSKATRSQASTSKAMKRSKSSQPSDRMVSQSNSSSCASELKSKSKRKLESECGPSKKRAVEVVTDTSSSIPTSTAAPAPVKIRAKVLAGNGAYDAAKQSELDDFANSRGAGERKRTDDGLRIFSPAELGMNDKGGDTELCPFDCNCYRDIALFSVATLYHTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT63</accession>
    <name>W3VT63_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT63"/>
    <dbReference type="HOGENOM" id="CLU_2016226_0_0_1"/>
    <dbReference type="OrthoDB" id="10628388at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833271" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="12863" checksum="29F6AC6F4217B96C" modified="2014-03-19" version="1">MRCSCLGAVHLLSALGLSSSSDAARDDVRNSAERDASDQHAALHAAPSSRLSGSSPSLLAAGKAQYHARSCPHELARPPRTRCNDLRCSFTVQPPCSASPVLQPGSLVSILASLARPYPVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT64</accession>
    <name>W3VT64_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00768</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_2_4_1"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.120:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="389"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1205"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1416"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1517"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1463"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1531"/>
            <end position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1781" mass="195710" checksum="AA00BB4782C51A88" modified="2014-03-19" version="1">MDIKKPITSAIASASFSFLTAEDIRRISVKQIINPVLLDTTNHPNAGGLYDPALGPMRPHDICATCHLNSYQCPGHFGHIELPSPVFHPLFMGNMFNLLRGTCFYCHRFRASLPVLTKVIGRLRLLEYGLVDDAENIDAEEPRSYTKFSDLNNEEFETANEDSDPENTAPKKSSSSKPEKSSAGETPAEFADRINKQVKELIKQAKASGKATYEPEAGSLAYTLRKKCMNDFMKEIHKKRCGQCNAISPNVRRDGFLKIMEKAPLPTEIASNEQKGYLRISPVKRVAAIERRLAASAASTSASAENDDDASGIATQAISADDAPKEAGYRVMPAVECQAHLRLLFYNEGPLCSLLFGRNGPFRLGNSEGKVKAKTGSAIWSTPNGASADSFFITAVAVPPTRFRPASIMGDMTFENSQNELLTNVLKTTFAIRDQITELARLTAKKDFPELGPDASESDFRVAETQLIKSREDMRRKVLNSMMQLQVDVNSFIDSSKNPMPLRQGQLPPPGVKQGLEKKEGLFRKHMMGKRVNFAARSVISPDVNIETNEIGVPPVFARKLTYPEPVTVHNVQLMRQLVINGPFKYPGAVAIRSEDGTETQLDKLSVEERTALANQLLTPQEHSSKQKRGTFAGLGSSTRTPIANKQVLRHLRDGDILLLNRQPTLHRPSMMAHKARVLVGEKTIRMHYANCNSYNADFDECYYVANTDNQYLTPTSGNPLRGLIQDHVVAGVWMTSKNTLYTRAEYQQMLYGALRPEGKYTGGGRVLTVPPALLKPEPLWTGKQIISTVLLNLKPAKADGLNLTSKAKVAGRLWGKDHASEEKVVIEDGELLQGVLDKAAFGASAYGLVHAIFEIYGSETAGKLLSVLSRLFTKFLQSNAFSCRMDDLLLSKEGDEVRRKALNAAKGEGKGVAMKTVGLEGEDENNPDTDRNLRIRLEEVLRDDDKLAVLDGEMMNSSNALTSKIIESCLPSGLYRKFPENNMQMMTGSGAKGSAVNVSQISCLLGQQALEGRRVPLMVSGKSLPSFRPFETSTRAGGFVSGRFLTGIRPQEYFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGVHIQYDNTVRNADGSILQFAYGEDALDTTKSKYLGQFDFTAANFENYNKRYDPKQLGEVVEAELAAEHMKKALKKPHKYEPVLSMYNPSTHFGSMSEKYAKEIEAYIEKNPSKLLADKKKKSKKRKSEATGDADGNDDGKVAEKLRFAKEKLGVEAFRAMCKVLYHRGLVDPGEAVGLLAAQGVGEPSTQMTLNTFHFAGHGAANVTLGIPRLREIVMTASQNIKTPIMRLPVLEGITEDQIKTFCKDGSRLVLSQVIDEAIVTEKISPKSSQTGFHRQKTYTVRLNFYPADECKEEYNCSTQHILHGLQETFAPNLENNINNEMRKQRREHAVQAAAIGRGRTFSDNAAAGNNADDDGEERANAAQPRSRGNDADSDDEEDASSEVGDGDADEAKRKQRSAAHASYEEGDDEVMDNVPSTMEDIEAAFSGESSKKSPNAMDVDSDSSDSESSDGSVNEDWAEQTSALEKALQQNSKYINAFRFDEVKARWAEFDLTLAAQSQKLLLINIVERVCRQSVIHEIPNISRVMKPPPKAGEDGVSLTAEGINFRDLWNFGFGVVDLDNLYTNDIGAVLHTYGVEAARAAIVAEMRGIFDTYGIAVSPRHLFLIADYQTAAGGFRPFNRSGIAESSSTLLKASFEMTMAFIGGSALHGEVDTLKTPSSKLVVGRPVSSGTGTPEIRLALPNPIGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT66</accession>
    <name>W3VT66_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT66"/>
    <dbReference type="HOGENOM" id="CLU_016388_0_0_1"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="865" mass="93096" checksum="52FB371B68C04BC5" modified="2014-03-19" version="1">MRSDAQQGETRVAMAVLRVDDGERMRLEQMSRGGRKGSSAPPFARQAGTIAVSNPRQPDEAIRNPDTAPEPHVVCANHENANFAAARAARTLRGLGSCSWRPYILKEPLIQIALLRTCLPAFTSLPASLRSNRPTGDSGSPIVCQVTSLLHWNHSTILTLGLVGGRSDGSFPHIARRLARIDVAQLSRARSSMPRASDEERQLLLAEERATRQRAPSNASSNRPKPTRRFARAAHHLKHHWPVLRLLAVALLWGMGNYGAAPSYLDGLRAYTCAYHYSKHPELLPTHPHPPLPRDRDRPCAVSGVESRVGIVVAAATMLSFVVSSVSMLFYGPRLARWGRKPMLVISLASNIINYLPFALLPLGYPFGDIPSQLAISPAAAMLILLLCSFLTGLTGFAGLFLCVMRVMIVDVAPPTRRTVNLNWLISATLCGAFFGPLLAAWALDTSVKHRTHAMLVQLVGAPTIRSELPSDPMTPPPIPGAPQSPSKHGNPAALVACCWVFLLAIAWTVLIVPETRPTTAEASASHSTAEFTPSRANAARSAEDDGASTHGSLSPSRIRARKLLGPLSIYLPQLTHDGRKDYRLTWLAFAGMFANIGTNALQYVAIFAGYKFDFTPDAIGLLLGLIGATRAVWLIVAIPLLVLLLERTVRKPSRIASLSPQELEVYAKAGLKDPDLTQPAGRLAEELENDGLAQPAQPPQQGSLDEFPADASTETIRAVVLWRTAIDLVIAKISYFADVVGYLVVFVSASFSNAAVMIFGTLFLSFGAGAGPAVASAAIAIIQDMKRAGHPSLHPSLHPSPTDDWLAALSISDNIVNGISPILISIVYSLTIETALPSTCFLIPTLGYVLSFAFLALAKSPSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTB0</accession>
    <name>W3VTB0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTB0"/>
    <dbReference type="HOGENOM" id="CLU_046576_1_0_1"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="441" mass="47662" checksum="58863A72257781FE" modified="2014-03-19" version="1">MAPKKAAGSAGGSPSKASHASRAAALLSKARAQASSHPAASTSRASTTPSPTKPSGAASSSSAIPLPELLKTLSSKGGLTMRDAMAVAGKLINARANTPEALAHISLIMLQDIGVESEEHRKRAVLAFKGKRAAGFIATSPATTTSAGLAPDFGTYRKRRRADDDETLGREYGNVTAPSDSRTRRPVQIEYTFNEVLEADALRGRYAVVNRAPVMTAWAVVLLERLGFSRPEALSLAHCYVNYTSTMRGISLGIIPAAEKERAVHTVGPNQPHFELMGVKIPVMHMQDGTYRGISAGEVVGPEKAFGYMRKAMAQTLASVVGALTLLADSFMEEQAGGEYGGEYLNKRGYELYAEFRPSTAGEWGKKGRLWYDKILALRRGCEAELREWNNKQALLEQHGPPEEEWAEDVERLVQEELDKEQARDAQVKTESTSAKQESET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTI8</accession>
    <name>W3VTI8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01357</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTI8"/>
    <dbReference type="HOGENOM" id="CLU_004312_4_0_1"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="569"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="90"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="389"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="489"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="840"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="976"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="984"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="999" mass="110500" checksum="6C846CC6375E886D" modified="2014-03-19" version="1">MLIHASEAETLNSIRLALEREEQQIRVNDSTGEVYDITISRSAPYASPVVSRSVTPSNANDPSTNGTNGHSSTTLSGHRILRLPQLVSKRAHGHSNHTPQQPSVVDAPSSTDRSHPDTHDPSQSPLRQSSRADENATIRSTAVGGPVVSQDAALKSQSSFTAPTRHHPFLSELPPSPPLEADYVAGHDSRNGLMSTVTNGSPYLPAYPTTNGASTSAQPHDAAASSKPLQTKAPVARRAYTADSANILGVSSSAPKPKATSALVDEPTELDAEEVFAASQKQHPQPQPANAAYNVMSKRNQRRNESNASTASTAYRTASSHGGPSDEEDDDASFTQRRHASYGSAASHLTLGAGISGAAPAIRLTHDASPYQHDAAPRAAEAGASQLYANGHSGVDQPGPPNGIPPRQHISRRNTTGSSLQGRRSQSGNSLAQSVRRSSRDRDPNYHSAGNAWEADALNSPTLAEATAHALRTGDAAFDEEAAMHAEQLRRDRRYKEQKARDAAAEGTSVDKDSASPGGVVGALTRSKTGRDWLNVNPKDKERVDRERERDDDAEPKVLVGNLIGEGHANYVLMYNMLTGIRIGVSRCQAKMKRPLCDADFTAKHKFTFDIIGRELTPTAKYDFKFKDYAPWVFRELREHFHLDAADYLLSLTSKYILSELGSPGKSGSFFYFSRDYRFIIKTIRHQEHKFLLRILKDYHEHVKANPHTLLSRFYGLHRVKLPHGRKIHFVIMNNLFPPHRDIHETYDLKGSSIGREYPEEKAAAKSGAVLKDLNWLKRGREIELGPEKRALFEAQLQSDVALLQRLNIMDYSLLIGLHDIRRGNKDNLRQDNLRVFQPETKELKRQPTQIKRPGAGEQDASALRQAVRRSDPKALNAQQGSKLPDRDVSERRHFLFYQDEGGFRSTDENNQPGSMIYYLGVIDLFTPYTSVKRGETIWKGLTQNRHMISSVPPKEYGQRFFDFLCSVVTGGDKSRRPKMWGFTEKDTKSKKDKEKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTR0</accession>
    <name>W3VTR0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00842</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000135_0_0_1"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="6">
        <location>
            <begin position="1210"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="7">
        <location>
            <begin position="2093"/>
            <end position="2665"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="8">
        <location>
            <begin position="3199"/>
            <end position="3306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="857"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1134"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1492"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1707"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1856"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1053"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1492"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1717"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1868"/>
            <end position="1884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3330" mass="370367" checksum="218CB68F5B06F8DE" modified="2014-03-19" version="1">MLEGVLASLLNKLLAAYVDGLNTSQLNVGIWSGDVKLRNLRLKTSALDKFRLPIDVKEGYLGDLTLSIPWSNLKGKPVRILVENVYLLAAPKNASVEVDEEEEAQRAQAAKQEKLTNAELLGRDSGQSVGISSEDEQKNQSFTSSLITKIVDNLQFTVRNIHIRYEDSLSNPEHPFSAGITLAEFSAVSTDANWNPTFIQNSGDGIHKLARLESLSVYWDTDSDSLAGHEISEAQKKFNALIARSDSTPDHQYILKPVSGAGRLVMRKKMTPEVPKMDAQLLFEELGFALDDEQYRDVISVADLFHFYTRQAQYRRFRPTPEQLAENRPRALLRFAGAAILNEVHERHRVWTWDYFRQRRDDRKEYVELFKQKEKQVQKTNQQQAGVAIAQSDSGSRLEELERKLDYKDIRFYRSIARHELRKESLAAKKDEIAAGGNGHGANDQKAAGGGGWLSWIWGGGGGQQQHGNDSGVLNEEQRKELYDAIEWDEDASAAALTQAVDAPRDAMHLRLITKLKTGSVALKDHARGTDILSLVFDSLQANVIQRQDNLEAAVALGGLRLYDGTTPNSLYPQVVRVKDEELDSSSRQNSGGGDLKQIEHEVEQESDPDNPFFYAKYELKPLDDRADNALTLRMRSMEIIYHRGFVESIVRFFKPPESELELIGALIDVASETIEGIRKETRAGLESALQNHKTIDMVVDVKAPIIIIPEDVTTKKCQHMVLDAGRIAVRSVLADQNALDTVRSKQNRAYTDEDYRQLEDLMYDRFFVKLESAQLVMGNDIDSCMKGLHSNATDHGLHLLERINLDFTLHNSILSSAPNLTKFKMTGHLPTLRVNFSDRKYKTLMRIIDVAIPNFDDDSSAGSSPTKGLGTIEEELEPVAIGQRQTGKDDDDELDKDADKDDARSSRRARGRPSDALDLNKARRQRLAGQLRGEDDYLVDAGLDDDDGKDEFQDAEDATIDKVNAHQKTFELEFVVDSLQGSIFRSATDPSQPDRLLVDARFEGFLLHLAVYPYHMDVDVGLRSLELEDKIVDQGAQFRHLITSKQVRDGSSRSATGDSHASSGTASPSDQRDLVRVRYTRVDPESPEFMTKYEGIDQTVNVELSTINIMLTRVSVLAVYDWIMTTFVAVDEPTASSAQESEDSKQRRPSRSSDRRPSDATSKRPSIRPPESAGAATGGTVAAANGNGERKEKLRVRVKLNSIVLRLNNDGTLLATLTLSTADVAVMLRGNTIRVAARLGSLLLYDNAKRTVADPHFKKLLTIQGDELADFTYETFDVADAASYPGYDSSIWLRSGSLKFTFVEEPIRDLLQFFSKFAQMKAVYDAATLAASNQASQLQERVDRMHYDVLIKTPIVVLPRSADSPDVMTANLGEIYAKNTFAMRDNKEAITKIEAGLRHIRLASRMRYGSQEYHVQMIDDVNISLDMVQSDRAGAEPGTANDSPETQMVAKMSDVHIKLTEAQYCFVMALTQSIPRAFAGLAEEANGLDDAASGAATTSGAAPSASTRTPSGQLQQQPSTPRKRKTDGSDLGQDGEAESTSATPTKKGPGVDMLPELGTIVHREDGDVPVYTSLDMFFDVSSIQLELFTAAATGQETLYNAQLARFSINGSEVKLKMLSDNSLEAEVALKTFTVTDQRPDKDTKFREIVPAVKHEGHQFMMSYSVSGGDDGSALALVTVDSPKIIFALDPVFALLNFFMSAFPDTPPEEEQKASAHDQAAPVQQPDAANAPPPAGGTFAFRVNVVDPTIILLAAPERHDTEAIVLSIKQVLMSQQGILALKVDQFGMFMCRMHRPKDTLRLLDNLDVALSMDSRVSQTSSTTSIEVDVEPLVLRVSMRDIMMIQSVVNKAIELSAQQPSSTGRADSKSIASSQRRQASMASTSNTIDSLTKVAKPGVDDGSSTLDARPPQRIEDAELMIAKESLRADFAGVQVILIGDAHSLPMLDLNVSKFAVDVRDWSGDMHGSTFLDLYINYYNLSRSHWEPLIDPWGVQFHMESSASPARFSATVSSKKRLELNVTTTLIETSLSAMSLLNEVDIQDLQQRNRAPFVIQNRTGYRIALWAEHDERDRKSKNAPQHLDDGKDMPWRFDDWKSMREHIHESGGNRLSLQIDGMPWERLRHISVDREGEYMLTLRPKLDKVAHRVQYEVKLHNNVKYITFRSSFKIENKTLIPIEMVILDHEGNVTDQVRRIGPGEDCPVPIEAAYHCRVKVRPDPGFEYDWSNESLNWQDLLKKSTRTLTCRAHDEGEAPFRFQSFAIYDRQDPNSRAYPRVTLRLRAPVEVENLLPYDIQYRIFDKNLNHNWSSYLRKGGISPIHVVELSHLLLLSVDIQSSCFSPSEFAIIATDNPDDFPVEKTLTLADAENLKLNLRLHYSKHPDSGGAFKVQIYSPYIFINQSGLPFALKTKSWLGSAKLVAGQDSGASAAMRREPEPFLFSHNSNDRRNRVLMRVGDSQWSKPLSFEAIGSETEVVIPSASKNEEIHVGLTVEDGLGKFKLSKVVKLTPRYLVRNNLTGPINLREAGAADFVTVEPGHRVPLHFLRVGATKQMTLAYPGINNKWSAPFNIEDVGSVHLRLAKAGQHQHLIKAEVLLEGPTIFISLSQEDGPWPFMLRNESDYTVQFMQATERSDEEGGGKRVDEAVGKRYELKPRSKMKYAWDYPAATDKMIKLVINGRERNVNILEIGSLLPFKFASADGRGSRVVSLDVRADGPTQTLVLSNYAEELSNFKLKRQNSTFSRSDTVSSVASRDAGFVAVDVDTNILTAFNVEFEGVGISLINQNVQELAYVSFRGLEMHYTESEVTTAVNVICKWIQIDNQLFGGLFPIVLYPTVIPKDGKDLEVHPTLQASVIMLKDESHGVTHIKYASVLLQEITAELDEDFLFALYEFSKFEGAAWQLEAEKETDFIEHPREVREPSGTQTASDDIYFEILHLQPIALNLSFMRTERVNADEKVSSRNPLIFFFNALTMALGNVNEAPVRLNALVIENVRLSSAVLQRRVVYHYSQGFLLQLYRVLGSADFLGNPVGLFNNVSSGVADIFYEPYQGLVMHGNKELGLGIARGASSFVKKTVFGLTDSVSKVTGSIGKGLAAATMDKEFQSRRRMSRFRNKPRHALYGITAGANSFFTSVASGFEGLALRPLEGAEQGGAGGFLKGVGKGLVGAITKPAVGVFDLASNVTEGMRNTTMVFDQNDIDRVRLPRYIASDGIVRPYSDREALGQTWLKNVDNGRLMKDSYVAHVDVGSSEGDAVIMLTVSRIVYIRTMRLKVMWEVALADLSSISLESQGIALVLRGGVSGPFVHLPDVSTRNWLFKQVSKVVQNYNAARQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTT2</accession>
    <name>W3VTT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00407</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTT2"/>
    <dbReference type="HOGENOM" id="CLU_027221_0_0_1"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000049">
        <property type="entry name" value="Vacuolar sorting protein VPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="71"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="517" mass="57193" checksum="EEF99AFF91E4D453" modified="2014-03-19" version="1">MDAEEDTFTSVTWENRDAATGSQPVFSTMPSSSTNAAAGPSTTSASSAAAAGLARDPFASDDPSELTWAGYLMVQVLEPRKELEGQKDAFISYGIRAETNLAHFSRTYMATRRRFNDFTFLREGLKRDFPACVVAPLPDKHRLEYLTGDRFSTEFIERRTQELQLFLERICRHPTLQRSQLLRSFLESSEWHVDMHAHNSSHSATNAAASGTSALVSGSHVENAGPPGLLDSISDHFLNAFSKVRKPDQRFEEIRESIDKLEEGLAGTERVLSRNRNRIAALPFGDLYAPQLGTALEDLSTDYEDLATSIEGLGYLESGITEPLNKFAAAMLEVARLERATSAKSTDSMLWQMQAMLAYARAHKSVLKLRDTKQVDFEELTDYLSGVVSERDRLASLSSPYGAGHGHGGVRGAGISGYIKDKVDHLRGVDEERTRVGRMQRLDGKIGELGDAVTSAHDTSHAFNAQVMREHQIFHQAKQLELKDVLATHADGQIELYTELVGVFDALIPQLERIRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU01</accession>
    <name>W3VU01_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU01"/>
    <dbReference type="HOGENOM" id="CLU_362970_0_0_1"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="23"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="794" mass="82438" checksum="B2E5C66B9ABD95B8" modified="2014-03-19" version="1">MATTASVYNTSRTTRQILRRHRKDKPSLILHLHNNHFRFERQNGMFLFDSPVKAFLGFIRDQKVPADLIDVLTESGIKFFEGCLLVDVHDHRSHAAASASPLGPRELMGMSAADLFRSRDTRDPMSSSALGFDAEGGLASSLFYLQEGGRYGARKLLGGTSSSDPRGGGAGGVEIYRIVLHPTSETLWADIKMLDDMAGSMWTDQEALEVEAKILALTAPPLCLTPDPQATRIANLMLSATALPSAYSPSQDSPFRSSKKRGANSIEMEREEMDRQRREKIMRLMQHGHKGALHAGAASGMMPGAGRSGSAAMDPSAMLNAQGASASAAAATAFVPTFGRMGFIERWRMGRNAAMGPIPGGPAPGAATGAANGAPGAAGKKDTKNDKEDADAGNASAAKKPPSKKKKKAQREKEEAEAAAAAETAKKKAEEEAAAAAAATKKPKKKLTKKEREEKERKEKEEKEKAEREEKERKEKEAAAAKGSKPKSKKKQKEEAAAAAAAAATKSPAKGGKAAAATAAANGTDAAAPSSPGKDKKGSPKKAAGKKPAVSAAATTPAPASATKKKTPAKADKKGANANSTPAGSAGGAYGAADAGVNGAAAAAMQGTPILGSATPSVQSTPTPAHRSIPSQPQQGQMQAQTTPQMQQQQLTQQQLQQAALAGMFPNMQAQQMGFNNMGFGLPMMNGQMGGFPATSNAQNTAAALAAMQGMGMNQFGNANNGMLNFGAGGNMANLGQMQQMMGLMGGGFNGMPFAGQQQGQQQGQQQGQQGQQGTGDMPVGVGLAGLANWGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU73</accession>
    <name>W3VU73_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU73"/>
    <dbReference type="HOGENOM" id="CLU_321632_0_0_1"/>
    <dbReference type="OrthoDB" id="3360377at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113660" checksum="FE9D55ABA4F7472C" modified="2014-03-19" version="1">MLPELGSRNLTSSDRPFPRNVPSSPSLLDCHHSPPRDPSAHSGLNIRHHRPNGRLGYAFMRPPNSSLPARDAWRALAHQQRQLRLLSSAALSASSASTATASTSSANSPLFPLRLTFSATPSSPTKVRSARRPRPLFAFAYSTSNPAYPLPGSNNEIDPHGVDFSLFEPEDEVYAQQASSSTSIKSADGAGQDTSTSMTGESIAALSPSTQLLARLIQEEDFKAASTALYQFQSLGTTLNEPLPEFAVAALWAIKRGRRHDMLSWMRLCPEYTPSKRGVEAESSVSYAGQDDPTVSHILKCFVVLLEGYGDELELLQQASLIAAEKGHWTVIRSSLAQILRYGIGGTYGSDASHSVLAWQYFKQLVLGHRRERARRLRSTRQELMPAHLELRALYNLGIRTLALAGRLDDAISWAQHSARTSHTAEGVAHIVSTSNFTQRLLFEELFRAGGEYVQKAYSLAELLACSSKRGRRAVELANVDGIAKRIARETASSLEAESVDTEAEPEARLDAILQTHLDQGDVFAAREHLLSVLRSAEKVRRTDDSPMPEDYAPGSKDAAVFAHLPSARTLSRLQDLAYSYGTVPITVSLTESDVGPAGTTDGSQAFPSQEAVGADKFLSPVRKRLLTVRGGKGLYETATLYGLVKKAKWKAALDFYVGSNGFKMPAGGITSELIALALAQSGLPPSERSGHELAARRLLGKYWPSTHAINLVLRAVVGVCMDAKDYARLTRVYELWKETASMRRMPDSEHEGEQEQNHTQEHEQEQENENENEHEDNGSASLAFEHWPPSQPPSSRTFDGFIRAFARLEVDVATSGTASGTESETMPGQMKKQVWGSSQAVLGVIRDMTERFGVRPSVSTWTIALECLAREGRERWTNTTSILARAVGINTISPLSAAADEAEPVLAQGDFAPANLTTYTAVVHALLRVSHGDGGSMVEEAAAVRDDLLARTVDLDLAVRSLVRSERNDGEEAETFWSDLLERWEAVQQAVSQRGAPDQRQQWHAHKMLKANGGRTVEALRELWLLESSPDTPPQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUA6</accession>
    <name>W3VUA6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUA6"/>
    <dbReference type="HOGENOM" id="CLU_048955_2_0_1"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="253" mass="28198" checksum="7EF15B7F3A960928" modified="2014-03-19" version="1">MGNDGGSISKRDEMVRTKASMQKVDASLLRQSLWTVCRLSREPLQAPVVSDALGRLYNKDAVIQHLLQRHQSEPTTDPIPHIRGLRDTTDLKLTTNTLYRPASAGQSEQHSVYPFMCPLSARQMDGMHRFVYIAPCGCVMSASGLQATLTDARGEVHPCPVCAKHFHAALTKGAKAVQGSDVVTINPDKDEEDRLREKMESRAQHKKKKARTADQEDGKDTEQEAKKRRKAEKKDETRKRIAQLTAELAAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUF6</accession>
    <name>W3VUF6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUF6"/>
    <dbReference type="HOGENOM" id="CLU_022332_1_0_1"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="149"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="616" mass="67117" checksum="94E8B40D631724D8" modified="2014-03-19" version="1">MSAQHEDARSIATDRSLESSESDILFFPTASSARNSNDAAPKHSSDTIRGSKSQPLASPLREHAEVDDEHAESQPLNRTDTAPYHDDAASTGHRTPSSTFGHSLDPGAYWRLAEQASAIPSTRSLERRQGGTLKERRDAYWKASVVNVLLILSWYTFSTLISVYNKWMFAQDKKNFSFPLFVTSFHMAMQFVLSSTALKIFPQLVPRRPNGTTSRPSGKHWASKVVPCALATALDIGLSNTSLKTITLTFYTMCKSSNLAFVLFFAFLFGLEVIRWSLIGIIALITLGVVMMVAAETKFVLIGAVQVLSASALGGLRWALTQMLLDRDEMGMNNPIATIFWLAPVMGVALISLSAIFESWHAIFAAQSGYFDTAAHALKTIGLIGAPGILAFGMNLAEFALIKRTSVVTLSVAGIFKEVLTIALASSVFGDELTPINVTGLCITLLGIGMYNLLKYRLITRGADSVGQEIAGLNELGESIRSRASSIFGGVPGGGGGAGQRVGSSRGGGRGGGYEHLGADADEENDLLFDEDHERRKGARRKNTGESDALELDTQRVSQEIISKPYSERAMTDEERERERERLRKIEEEADMDGWNTSGERITGQGLVEHEHVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUF8</accession>
    <name>W3VUF8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUF8"/>
    <dbReference type="HOGENOM" id="CLU_1741363_0_0_1"/>
    <dbReference type="OrthoDB" id="2550614at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="150" mass="16188" checksum="0D74DBADB346822E" modified="2014-03-19" version="1">MVVLPPPTFLGAMSSAPHLLEVFATGVYVVTSIIVASYASSAISRPGVRGYAEAWRVGAITFCLRSGRFTLTRITTGASRCSGRSSASSERRAPSLCRFDRLKSDINEKPMTSNLLDAVDYVVPQTGLFGETNVEADDEVVVVVRQAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUG3</accession>
    <name>W3VUG3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Benzoate 4-monooxygenase cytochrome p450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUG3"/>
    <dbReference type="HOGENOM" id="CLU_395413_0_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="697" mass="77679" checksum="E2DB002869AFC47D" modified="2014-03-19" version="1">MVLGPPFDAVTPGRLDAHRHGACKTVEQVRSLQERPGILEDLDESGPRPAFGPGKKSHVTRALASWNRHASWVAPNLQRFGSKRKDRCDGQRCLALVFPAFFFEMSAWTAYVGTRVAEVRAHSDESVRLGVALVLALATAMLMFARTRQQRTAVFGDPKVENAALDGLPAWPGARHTLLNSTCPDTEHFELLRLHDALASPIVRTGPNQVHIADPASHKLVFAQATRFEKAPLYDLFNAEPGKANLFSSRDAKHHASRRRIVSHAFAPSSLTEFGRAAEGGAYEDVFAAYQQFTGDIISKFAFGRDDHMVENGTFPPSLTVFRAVTLKRYSLNCVLFADRSFFPVYSWLAARLNELLLGIRSRTGSLPQSLFLYQWLRRVPLGLHLVRLLPAGRLRTDLEGIRDLNALMTGYIDEFLATRRDDPREILHKLIHARDPVTGEGMDKQTLVGESRGLVVAGVETTAAALTYLTFQLATHAHWYERLRDELAEVIPDQEAFVRDVENAVPEERAVVKLAFFNALLKETFRFYPAGVRPFPRTVPPEGLHLEYGVFLPGGTEITCSSWVQGRWDRALWGDDSEVFRPERWIEAQQQPSDDYLKDAPGREALRSARYADMASSITTFSNGPRGCIGRNLATLVLHLTCASVFRCLQPGVNPDSQATDPPVKTSEHDMEYIGPFVGNPRAHKLELKWATATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUR0</accession>
    <name>W3VUR0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase TEL1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATM homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">DNA-damage checkpoint kinase TEL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Serine/threonine-protein kinase tel1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Telomere length regulation protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PaG_01028</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 27">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_11_0_1"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="23">
        <location>
            <begin position="1994"/>
            <end position="2602"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="22">
        <location>
            <begin position="2737"/>
            <end position="3047"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="24">
        <location>
            <begin position="3081"/>
            <end position="3113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="417"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1912"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2610"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="3026"/>
            <end position="3045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="2616"/>
            <end position="2632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="3035"/>
            <end position="3045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ETS64562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="3113" mass="338758" checksum="D83F890F879C1AF0" modified="2014-03-19" version="1">MAFSLQEALEQIRSDKVKDRQQGLEAIDHIFADAENVRNLDPKHDGRAWLKTFQSLFACVLAEKTACIRKGSFVDAQPTALARLQRAAQTLRSLVDKSASLLTRKVVKALVIHIHQMLNHRGTLLQPIAPAYIAALCTILRLPHHVDHLDPEDWSAVASLCFDVLLTRELGTDIATPADAQQWLATATSTQQPPLQRRGLSLEHAVTAECLSLLISSSVAPLLGPHGFGLPLLADYVRFLLAFPSESSAHLPTLTGLVVLLEHLELNHTSEVVLATLAVRHVLLNLWKTKNHLLKAQLLLLFRIVTDLIASFALARPDAASSQHHVLPSDDAIAFLQAIHDTLLSDPDSRWALEPLHIDALLLRWPQHPQPVHRHIALGNAAFSLSPASSDRDALAWCRIGLQVDLIDALTTIAGQPIDRSDRPATSNLDDHAAAPSTQVSTSPAKRRRATTTSSPQKRSRLSSNQPAGLSPEAQGLIPLIGMLSHSDASAPSSPAARLSAVQLLTFLVLGKPHLLTPTAIDRLEKCLLALTADADTATVSWSLLALASIILMHSPYADDASRQLSATQAWVIATRKLQLPATSRAAAYLLSVLLASSALPDSKLQPEIARLLADIDLQGPPIVCDSVCHLMALLLRHTTSSRAFHHLDPRAKIGAWFASTYSPSATISSSASSGSFVSYDDLIRLVDCIVAESHPQSSSRASLDVTSCNPGAAFASAQRRARLQPLRDLLLRSAIAHANLADVTFQSDATAANPALMSAEALHRMTVVLDRNVDACLNALQDFTADTNGAASLTGHAAIAALHLAILALDIGTRSTSQTGSHRASSIRSCCQIVVRILAIASSVDAVRSGTYALAIEQLTLLSPSAAFTSVSSRTSDLLVDPGPSSGIAARLLVKEQPEQPRSGHPARDESSRRIWKAIRDVNMLDTVLASCAKLFEVTLFGDDQAEAEPSSQVPVGTGDIFDDVPESSSSTLLNATAAAHVGSPASIEVVVRSTVRLLLDVPRIVTGAADARHQELVVSSFFDCSVQGIVALAPVLFDSFCVGTLWMSHRDVNDALDRLGTELLASYRFARHPAARLATIRAVSCVMPLLLGELDEQSDLFDKVQKLSAFFADQIGRTKWPTPWEVQLACAEFLAERLRLDPDGRLLRSGTARAPSASPVTALLKLHTDPDVRVRALGSPIATSVVSTFTGPQADLDELYTTFRDGLPSDSTQPRLILTRALSLCNAAIASSSVRRSSIFYLLEIVLATGMLSSTVQELFAKLAARLGFADASSCYQAFAGQITWGLATNGYDPLQLPWKVLGYASKRACLEATFAACGSMLLATQTADGRTQFGALVQLTRRDRQQGLQECLPFLTAAYIGFAAQAEQGTSSDTAAICERTLRDLASLGVAEGDDAAALREMIVQADDLTISTLLLLFYEPGATLADSRTSMLEALSPLDDKCAKTVKALTPTTEDGAASCHEPSRPFFSAAVLYTALATLPQLGIAAFAPQTVYNVLRHMLYHISTSRFVNDQLRMCAALRIYIAMCGDAFWKDALNNQLLIRSIERLLEQPQLHDEFRPLLVYACTASCLATKAPEALVSCIVTWSQQLAERLVASPALGAWLLEAANALARSSPVATSAVVLLWPVDLTNTEHTAVESLVDIGTLTYALEACPTLSHRLPSLLRIRSVLTRADKAQLAAFCKGPAWKLLERAADAARGRVGQDGDPLGDVINDIFTAIVGVQEAACLHREARRLGGKWDLQAVEDFLEAADTSHIRSLSAAAILTVHQLAQDLPIEQGYQAYEALRDMAAGLNEPLAAIHPAKMPAATRQELSRVRPGLGPPLTAPRTADAQDVRFAELVDIASSADKWLCRMAAILCDLVASMPHLAVFRPARRLVEANAEAAHALFPILLLCFAADDAAQGSSAVATENRKRSGGSVTPSRAQRDQALAATRTVIAQHFEAVLNCTTSGPTCSEIIVQALLALRAFRPVQSEPDNVCFWYRVDPSLLASRCIAAGQLTAAIFFLEHGIQNATEKPGATMLRSANQLLHQAYMNIDDPDAFYGITDGDVRDSVLMRLHHEGQWLRAFQYHAADYEACTSHGERRRAAVTLGQSLQHLGFPRLVDGIGLNNAGEDRFASVRDLGGSSASTSWDLPVASQSLQDKAPSVEGVLHTLRQASAEQDVDAPLSHAFRSKLQALCSTSIESAKALRSLQGDLLALGQIKDWRRASSSMGAEEAVAHLRSQWVRVEASERFELTERVLDTRQSVLHAVRQRMQVDQIGDVLDGPVEDVARVERLLLVASSRRAREHGKLQKAINAVARAQRIEDALGDGEELAREEFAAVLWDQNEHSPAIQLLSQVVDGIGVTQSSSASQKRRAARLLALLAQWRATARSQQPREIDRSLFEPALKLTAVAESPTASAEQSEIAYRWARFAEQHHRDSDLAEITRLRLYTDRRREEIAQNQRECERTTSKTERSKLLQFQRQAEKILLQDETRLMELEASRTHFLRRSVAMYARALATSDEHDDAVPRLVSLWLEHAADAELNRLLSTCLPSIPSHKFVGLMHQLSARLTELPDSADVMVPFQTNLSRLLLRMCQEHPFHCLYAIFALIKTGADAKAAATHRPSPRNTLSVPEGGASQSASPPVLRSTAAEKIWTHIKRRSSLGKRIRTFEELCLAYVEWAEFDLTSRADRYFQNSGSIKKGALRMPPSGELRLARMRDLDIPVATARLEIDATCRYESFVSIVRYGETFTTAGGIHLPKISECIGSDGRRYKQLFKRDDDLRQDAVMQQVFRMVNGLLEADRRTRERNLAIRTYTVLPLGPQCGLLEFVTNTLPLGEVLIELHARYRPQDITPAQARAKLRDAQTMRAEAKLEAFLDVCQAMQPAMRYFFSDAQRMPRNWYATRLRYTRSVSTNSIVGHVLGLGDRHVSNILLDQASGELVHIDFGVAFDQGKLLPIPELVPFRLTRDLVDGMGVHGVEGTFRRCCEETLRVLRAHGDAIKTVLEVFRHDPLFAWTSNPIKVLRAQEAAAAAEEESVAASMDRSGSTAPRVSCSTTPMVAVGDGMGAGVDTAELSADRAVSSVMSKLSSSLSVESTVNDLIQQAMDAGNLSAIFHGWQAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUS5</accession>
    <name>W3VUS5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUS5"/>
    <dbReference type="HOGENOM" id="CLU_647451_0_0_1"/>
    <dbReference type="OrthoDB" id="59229at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="424" mass="46157" checksum="4B95C37377AC84F4" modified="2014-03-19" version="1">MSIRFHKGPSIITLFHDASSPASKQVLQLLTNTTRRTAQAAPSSGSHGESCVVEANGGGVGASEYLRQAAEPPSESAFQLEVVDRKANPPTAHQLRSIIDYLASSAESQQSEGKIEAKRAKPRYTPSGFDLKAHEQRRTALAQHLVDSDAGMPRIKDGPIVVNWDEGSAATSLDGVQHMLARLQQQRQEREPPSSHLPHLASPWFPSAVSHHHTMLALPNTNAPESKSLLEPQSIPPMHTFGNLDTWNSASPSILAAAAVGSLALISLTVHLYNASEWPQRGIRQKTFGAGSRGIPLPPYPQVNTKLTCHLMGIGAPLVDITFGRLFSPEVWSTLARPSWPTPHQLAHHNLRLCGQSFANPSRCQLGPLDHEPQIVRVQRAYIVSAIIPVHRWIQLKVHRHSASASAKTELVMLYAARTPHASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUX2</accession>
    <name>W3VUX2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUX2"/>
    <dbReference type="HOGENOM" id="CLU_406589_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000052">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834587" description="NADP-dependent oxidoreductase domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="391"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="631"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS65280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="676" mass="73637" checksum="A888826B15778A7A" modified="2014-03-19" version="1">MHDRGTLFWRLVLLAWGEAKAKRQSLVMPQKLEVRDARCKMHDAGGRSVTIEEGALAPGQLRRSEILRGALQVGGCQAPTRAQREQQPSQPQPNHGNALVPTPRTSAAMDRSDNAKQISRADRQLSMHPRLRLRGGRSGSCFHFAPVGNGGGGQAKIELMYNTVTVSSSVRDASSGPTPLHPKIRVLVLPEWLERAPSHKTCSAGMHAFEVDARSMLDDRIQLAHPLQIRLSGCKGLVRISSRIDAMRRRHHQLHARWDLRPAAASVAAASVVVATSVCRPVPRPTQAQLQSAASHSIGAAALRCLARLDEIVLPLRAPQQPRREPAPPPFVLTPSLFHPSLPFVSKTNLLLPIMSKVTASGIIAGNISTQRVKLNNGVEIPQVALGVYKAPNDGSTENACKWAFDAGYRHIDSAARYMNEESVGRALAEWTQANNVPRSEIFITSKLWDADHDKAAAAIEDSLKKLQVEYMDMYLMHSPGTMGPEKRLEAWKALEEAVDAGKIKTIGVSNFDVEELDHLLANCRIKPAVNQIESHPFFAHEELREACIERGIHIQAYSPMAQGQALDRPEIKAIATKHGKTPAQILLKWGLAHGNIILPKSLTKHRIESNAQLFDFQLDNDDMDALDGLDEGLKVGKLGPPGTSQPASPGGTRPGSRRSSGSGGLSGNKLQMSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVA1</accession>
    <name>W3VVA1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVA1"/>
    <dbReference type="HOGENOM" id="CLU_380877_0_0_1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="128"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="620"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="775"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="831" mass="89671" checksum="11BE8EDF9B3BA2CE" modified="2014-03-19" version="1">MRSAATRSSTRKTRLDGHDRSPECGHELVTVDLFQGWTPSAGSSDETEVQSDQIDPALSHDDPSSLATSADAPSFKSIGFPTSSLPPSLSTEGSVAQHDAGDEAEVKKIAPSKRPGVSHAKKTAPDHIKRPRNAYIIFRSHIVSQKLIPKEVEHDHRNISRIIAHMWKSLAQEDRAHYEKIAHEEKERHKQLFPNYRYQPTTRRTNVNKRNVKKLENGDEECQEIADIILKAQGKGGVAANPEPRKPTKRAREATRPQQENDTESAAEPSPRKRAKPTKAPSKVAKVTKTPKTQNVAKGTHGNGDANESEQTLESVFLYHSSSPSPSVSSCSSAAIASVAVTSPEPLQLSPETPPAARQGAHGDEQGTGASIFGRRASSVPLVPFYSLPPPPAVALSDHEGYQASAHPQSFGVPIEREQLQSIDGQLDVVQIDQSRDDGRDMPAPAWKGRRSQPPPIPNTWQNCSFDEPSLPSPRTMGFCGTSAKHSMGRPRTAMPSTPSSASCRGFFHPWAFDHSDESTLISPMNVSFQDGRRRSSIIRHGSLTGRRYGSFGLEPPSSFSSRAEPADLGCGGRMDAYPSDLDFFEHAANAASVSFREQGLSSGADEAVPFAFDPALEGEGCAPMPGHPLTSPRPSFSESTLAAAARDWTSIKDRKGRHSPSAARQPQPQSEPAPEPQFPTQAQDAGNLTLEESVERAVLLALGKHFGQDVDCAERSSKIVQQILSSFTSQSSNQPQASQAVDAEQGTVLERHNGANTAAPALDLNRRASLRGSCTPAGSFRSSPGINSVKAVDGRRSSKALPSPLHLARSNHQLAADSHAHPYPTSQHCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVE7</accession>
    <name>W3VVE7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00678</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVE7"/>
    <dbReference type="HOGENOM" id="CLU_1390778_0_0_1"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21025" checksum="542F2D6A88801BEF" modified="2014-03-19" version="1">MENDRHGGPQHGHTSAIPAGSLQASRCVTCSNASTFAASTGSSVSLHGSKKNKDTRGARFGKTPYDIQAAWYVLMIRPSTASQASVAPVDPDLADPKPHRHNTQSPTSAHRHTSGDLVDLYVPRKCAATGRIIEAKDHASVQIAVADVDANGRMIPGQSTVFPLSGFVRQLGESDDSLNRLAQKEGLLRNVWNYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVI7</accession>
    <name>W3VVI7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myosin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVI7"/>
    <dbReference type="HOGENOM" id="CLU_010459_1_0_1"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1151" mass="131133" checksum="12528DF361FAD1D2" modified="2014-03-19" version="1">MADRFAALAGYDAGSNYDSTLEQSLAAATRDDLPGLETVASINLDLPPSKPLNSTFGKSKKPSAAAERARRITSGPMDLGTGRSRSPPPHDSSASSSNKENARQQEPPSTQRKQEQRRHYGVRIAEDDTFDELEDSLQRGHQQDELQRMQQDMSQGGDSLLAASPANDSGQWGARAMRRRSAAGVSMKSAQEKINNLTQERDELKIVVDLLREKVSLDDRLAELIVLKKEKLSYTNKMIAQQAMLKQQDRAIKVLQKEQQQWKGGNPAAYEQRISELQAKLVAAENKAEEERREKVRLQDELDFVKRRGPPPGAPGDETSATSLGDSTRLRQRIDTLRDEHEDEKYELRRERDEVQEQLERARDEIDHLRSAQRRSSSPTETSHYRRNIDDLEQQLTAHKTENAKMLERHAQLVADIEQHKDELYELRSSEEALQRELDVANQRLEHANITQEDEAARFAEAERLAADRYQDQIDKLRDELASAQLQIDGKEAELEKLDGELQDLTAKVADLEYELRQAETLLEEQKVQLEGVEAEADELDRQVQAYKQEADELRAEADELHKELESKDADLAETNKEMQEMSNRMFGLEEELEARADEIKQLDEEIAKVEDALQQANEKHERHTGVLKEKLVLATQELTGTQGQLEATLGELEAMREEADTYAREVEQLTAERARLEDLNAKLDAKVSDVVEDLKAEERALDDAHAEWERKLEEVEERMARVVRDKDEAIVSLENELNQMEDDLATRKADVQTLQDALRTKENESFRIGQSSANDKYSLELEIDRLKRDLARCEDDLARARKELDRKDDVLRHKEDALAQMHSELREAQAKLASEMQSHLGLSERFEAQQNAVKAERKELDAARAKVEELEHELNNGERANLRSEQATRSALDQRNALLLTIYTQMGKLLASASADGNATPRKREAELKPFTNFDVFHTSLLGRLRRVFDTQLGVDQKAKELEAKLLEKYNALKRQQDTRFRQIDRFEASIKVATDKQGQWRQRLVSKQAELDAVKATNGELLQQISSLKTRNTLSTPADNTKLTALTTRANTAERRLQTALSQASQAEERLAEAKVKYGEGEGKWAARIKELELRCKAAEERVKRERQGAKERVAELEEIRRKLERDLDAATKRNRLVGDLQANVRNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW14</accession>
    <name>W3VW14_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW14"/>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="482" mass="52653" checksum="D70FF316552A07E4" modified="2014-03-19" version="1">MDSYDYVIVGAGVNGTSIATSLASHGFRVAVLDRSADGFVAPDGASHDLNKIVRADYTDANFCTLAKEAIARWRSSPVLRQFYHEVGVLFRSSASGDVWGNEGSAEEYVHKGIKHAALESDAHLEVFPAQEKARAYKLKNDTQVDEILGKARELKGDGFKGMGRVQTGYFNPRAGWAEANNATRALLGHAIKLGVTVYPDSSVDSFVYEAGEVVGVKTADGRVVRGDNVVLAAGAWTQELLTTLLPGVGEGWMTRPSAQCVAVVRLTREEAMQLGDTPVVINFATGFYQFEPTPTASPDEWHMKIAIHSNGYLHPAPQSSCSGTFPAFSCTDSTEQDAFGMAACSMPANQLEIMLEELRQTWPHLAQRERLVCTRVCWYSDTLDENWIFDSLANHPARPKGTDKVWVVSGDSGHAFKFLPIIGDVFLAAKRLLPNTRQLDLTRFTFNHHARTHADKNAGRAVQSADSNRAHSTPLANARARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX65</accession>
    <name>W3VX65_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX65"/>
    <dbReference type="HOGENOM" id="CLU_1138423_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="244" mass="26028" checksum="A539BEB6FEF8BE8E" modified="2014-03-19" version="1">MRGPKAVAERATTRAVWPGEKVEESATGKRSWRVWVGTKRSERGEGRAGVGFGLRLQSRAAQRDVTVGAGQAGQAGRASQSGRRSTPSRGGHFHLGLSSRHDTFLHQSSPGVPSSRNIARTDIDAAPAPTPSTKNDFSGSTSAEQQPSHSAAMLFVPMSLRRSAAEETHDWHQHIVTTPCREAAAATPPQHKHTHTHSARAPGHGVASVLDCKLQEHYVCAVFSAAFQAVRGRHVHPAPPTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDF3</accession>
    <name>W3VDF3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDF3"/>
    <dbReference type="HOGENOM" id="CLU_035268_0_0_1"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF60">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="249"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="387"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="543" mass="58771" checksum="2AA4041F40D53863" modified="2014-03-19" version="1">MTERLLVAGSNSGFQLGVGHKDDVRTLQEARCQLDARGPDGKPLIGTFPPQGYTVAAVSSGANHTLALLRPVGWTETLSGHSGLAEVWVCGSGKEGQLGPAYAAKRARQPKVFTRLDLAECLASLPEEDRRAFSGKDVEPSFVQCGWTCSYVVLATATATSEQSEVVSFGFHRDHHFGELGRPAPVDTDVGAPTDGVERCVHRVRLECLFEQVRLDADGYFEVEGIAAGLRHAIVALKYSNADYETTHAIVAGWGSARHSQVGNAIKRPSTARPPDKKRRAYVPKVVWEPQRMWSAEEGGGVWHFLDLAAGRDHSIILLTKYDRGGERRVRTINFGSNYKGQLMDAPAVCFVDGDPEDLIAVSCNWTSTHVLLEAGRCYVNCERIAHAVASCGSNSKGQLGDGTRESIAGDYGVTLVDLETVLNHRPTSVAGTADSERFPETEELSVSKMASGSEHTLLLVRRDLDTSLGFPYASTKEVWGFGWNEHGNLAQGEHDESDRDRPVPLINGSRSGAASAYSPLDIWAGNGTSFIRVEQRPGAPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE06</accession>
    <name>W3VE06_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial glyco protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE06"/>
    <dbReference type="HOGENOM" id="CLU_072692_0_0_1"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29573" checksum="DF631E2A08CFF2F5" modified="2014-03-19" version="1">MIASTLTRSMVRAASRAPLVRAAAVRPALAVSRVAVAPVRAFSLTPLVRGQGESDAELSAKLAQELEYEQENSNLFVGDSPTNEPGFVTEFKQAGVWKITDEPGLDEVTLSREFGNEHISVVFSVGDIDTSEQPAMEGEEAAPIEAEDDEEGPQFPVRISVTITKPSGGALMIDAFVVDGEVNTDNIAFYKDQKLATTIDAEADFARRGTYLGPQFDTLDENLQNQFEQFLGERGIDANLALFIPNYAEYKEQREYCDWLSHVRNFVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE45</accession>
    <name>W3VE45_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_05878</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE45"/>
    <dbReference type="HOGENOM" id="CLU_112993_0_0_1"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="116"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS59908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="198" mass="22087" checksum="DDE8B0FB961BB4A7" modified="2014-03-19" version="1">MLMPRASSYSQPGMAPGQPQQYDAPYAQMMPQPSHHLILSLQSCVSSTASCVQTMNEAIYNLNYAIQDHPRLVTVLKSQRHFDLVSGRDIEQAREHIASEVRPHIDELCRRAAAEISREDRRAVALRNRHEALQQRLQNLRSIDKHQSKLQEAPPAPTDPAVQAQLDNLNATLAALKHKKLALLAKADALEAEANPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE48</accession>
    <name>W3VE48_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_06306</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE48"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_2_1"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="223"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="525"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS59780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="966" mass="102858" checksum="C818919E48E7AAEE" modified="2014-03-19" version="1">MDDNDDGLMLNFAPAAASPAGAAKRPKQTAKARFAQKRTAQQLRRSEAKQTAATPGGNATSAPATPSSSRANTAREVVQRQRIEPQTASAPAAPAPVLPRFDPRSAPSTSRAASSAAASSRKVKTAAPAQAQPASNAGPSSSNAKSASGGVVSALFPAHGVIEDPNTPLLPFQRKAYDPTNAPSAASNFAELGLDPLLVYHLASKMKIGSNPTSIQQAALPHLLHPGLDRDILIQAQTGSGKTLTYLLPIVQSLLPLCEESFIDRSVGTLAIILAPTRELARQIYEVLEKLVSLALSLKEQNQDDDGAVRRTRWLVPGLLSGGSTKNHEKQRLRKGCPILVSTPGRLLDHLQNTSSFDVGKCRWLVLDEADRLLEMGFEEQLTGIVRALDGRRNLACTAARHAMPGFEEGAAPGDADWIADSDVMDTLGMTWWAHPRRVVLCSATLDENVQVLAGKTLINPKIVRGIKDDAEPTNDAADSASPDAAADQAGKVDKEPKKFAAPAQLAQSFVATPPKLRLVTLLSLLRAYISRARRQSEDADPVLRQAGAGRVIVFMSCTDSVDFHYAALGGAKMNADENAPDANVEVEDEQLPAHTNSELIPGVPIFRLHGSMSQQERIASLRGFSGRKSAKDAAPVGFQGSILLCTSVASRGLDLPDVGCVIQLDPPTEGGIEEYLHRVGRTARVGRPGESWLMVLPQELGWVDNVLEANMTIQATVGDDAVVESKNQGHAKKISPASIEVILQQGFGGATGTLEYQSRATGVQLAFERWVISGERPSLFARKAFLSHVRAYATHSADEKQYFNVRALHLGHLAKAFALREAPRSLGAKSASLATASTKFEAKTVSTGDKRARSDTDSDDDSDDEDGGSDYETRAKRNKTDGFELDKAALAKLTESIVANADGSNRSKKLAREAARAAAAAGVAGEKAKQTDAEARMYAKVRALGKMSKKHGVLGAHGADEFQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEF1</accession>
    <name>W3VEF1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEF1"/>
    <dbReference type="HOGENOM" id="CLU_372595_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="7">
        <location>
            <begin position="557"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="722"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="820" mass="89792" checksum="49C59FF72A866CCC" modified="2014-03-19" version="1">MDSNCWTGSRIPSATIGEWYFLVSGTHGNEKAEGTGRRQGPAGPCLPQSTMTSPTGEVDGAVRGLHGDALDLTSPSTGSGIRNSDRGQASASTHTSTSTSTSTEHRAPSTNLELIALECSHDDDGAKSGAAGRNYDRRSGSRFHDDESSHQASQTSIYPASRAAQRLRPNAPQLFQHSARRGLGQDDDQAKQSQRRTTSDSYILRNVSTDPELKHIYTQLARAAESKDAVHAAKLALLIKRRKEELCAPSGQVEFDPSERIVFLAIMRALAPHGLLQEVQAVSDDMCSFGFSECIDSLNHLLEAAVISARREAIDDILDRIRNLPPPASAPQAERSSKLANLLFNAKPDMSRPGQTTAMEMPLDYMQNWNATTFAHLLESACQDHNLEMASLMLSSCYRLGFTLPHRALTHAITLFLHSEEHRAAVELADLMEQGGLVHRHDVTRSAEKSASRITNPPGSGTSPGQVARRFPPSIWMSILRACAEGGYLPGVELAWSKAVVRGLQTPDDGLLQLILALSAKEGCVQMARNCLAHIDPSYTQPSSSPTEASSSQRPSSGLDLQEWHLAPLFEAQCSARDYEGAMNTLSGLFRRGFAITNRSTSRISTSIFPDKSALQLAVQALTKTAADKAIGTHIDIVNAVISAAVWLGDLAQALEIYRALPTYQVIPRDPANVKGGNRSPNKITPTRDTFNVLLSGCIDIADYETGVVMLKDLNALKLKPNEVTFERMIMLCLTQKNYEDAFGFIEEAKERDIVPSRKSYEALARKCFAQDDHRWELVLSNMSEQGYRPSSALLREFDLDPDAFRPKTRNRFAGRSHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEG1</accession>
    <name>W3VEG1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEG1"/>
    <dbReference type="HOGENOM" id="CLU_002458_3_0_1"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="712"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="762"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="790"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="71"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="282"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="512"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="838"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1084"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="858"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1135" mass="125747" checksum="F56627E8617F36FD" modified="2014-03-19" version="1">MASQYPLSLAAFSKAAATASSSAAATTTATLASAFLSLGRNPPTGTPGNNGSTDDPAIPLPNQRAFEGPWFSQQVSLSLFIGLFSFCIFVIVRRRNAALFAPRTKLKGFSPLDDGHDAGYFGWIMPTLKTEEMRILQTVGLDAAILLSFLKMGFWLFFALSCWSLVVLMPVNYWQNGVLDGVSPAEDRDNATDPNSFRDTVTGVWTQLIYDTFTKKHDDPSAPLPQLPLPAKPPQAQVYHAVHLLSTYLFTLLAMRAIWINYQRFVRARQLYILEILESIPARTVEIRDLPAHLRDEKALAEYFENMDMPVESTAVVRNTEGLSRLLNQRSNALHNLEKAWVRWLGNPTDAEGYDPEKIMLLAAGSHEDDVEPSSDDVDRPRQSRDDLESSRLLGPSATTLFTGADTIRTHRQRPTMRRSWWNPLSEKIDAIDELTRQFNAVDRAVRRRRKTGRFPGGNVGFVTFQSAASAQIAAQTVHYPIPAYCTTSMAQEPRDIIWSNIDLSNNDRRVRQVVVSIFIVAVLVFYIPPLVFLASFVSPGAIEKYMPWLDRLLDTDERLRALVQNNLPSLVVIGFNALLPLVLEYSSYLQGLKARSLVEYSLLKKYYLFLMVSVVFIFLIATTAWGVLQELAENPMRVIDKFAASLPKARFFSLSYVILQGIALQPLQLLQLPTLILRGFYRLLLTRTPREFAELNAPPTLAMGNVYPQALLIFTLCILYSIVSPLIVVFGAVYFGIAYVVNKYKLLYVFYKPYESQGQAWPISASRCIWALVLFHVFQFSLFSVRKQLLMSTLMLPLIVFTFWFAQHLQTTFGPLTEHVNLSSVVEVLKEVEPDPATAGLAQNGPPSMARADEVTTDTSGPATPRQAQGLSGANSSRQLLSLDPSHKIDPEFTKLALKRYSHDEEDETLFVAQRDTKTDYREPPGAGYYPGVLNTGRRRYGHPAITGILPELWLPIPKHRMDEGGDDVTAPDDLEGQTALASGTTALGAPARERVESGTGVQSAARIRARALSKAEPLILSLRKRKSSLLSRSTRNPASESSPAHPDTDALGVWSDGVAGPQGSSSSAAIGEALSGPYAVAPARKHVRESQGADTDGADLDQEEGVYIHRAASLARPGRPRSGVPTLKTHYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEH5</accession>
    <name>W3VEH5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05939</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEH5"/>
    <dbReference type="HOGENOM" id="CLU_033546_1_2_1"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000031">
        <property type="entry name" value="Probable PRS4-ribose-phosphate pyrophosphokinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000051">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF46">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS59954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="457" mass="49204" checksum="EDA846E43B871E63" modified="2014-03-19" version="1">MPGVNSIKLLTGNSHPELAQLVADRLGIPLTPCVCKKFADQSIDVRIGSSVRDEDVYVLQTGNSPYTDPNDSLMELLIILSACKTASARRITAVIPSFPYSRHDKKDKSRAPITAKLVANMLTVAGADHVITMDLHASQIQGFFDIPVDNLTSEPSVARWIRTKVDNWRDAIIVSPDAGGAKRATALADSLGVDFALINRNRRREQHKRQRAAQKTLGLSSRSSFDDLRSGVSTPMSNSYLLDGTGLNNANAAVGAATDKLNALSVSAESQGSAISSSHSSKHVYSDVANGIKCAETGEWIMTDEQGHRVRSGRSKKNLAESGTENDDDSEDDENTSRMEILVGDVKGKVAILVDDMVDTGRTLALAAKTLEAAGADKVYAIITHGLLSGQSIELVKKLSLERLVVTNTIPNTEKAAASNGKLEIMDVSAVIGETIRRSHHGESISQLFRQDAEIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEP3</accession>
    <name>W3VEP3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEP3"/>
    <dbReference type="HOGENOM" id="CLU_033465_3_3_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="302" mass="33695" checksum="4AA1022441B55199" modified="2014-03-19" version="1">MLHQRAQDDGADAVLGRFMPFEPSAAPAYIFCAINLGLCFVFLFHILRKRDWYALALPTGCLVQAIGYVNKVRFHSNPTFGLYFSGDLFVQIAPVAYLAFNYILLGRIAHVLESNPSITKSKRRLVGFSPRWVKTLFVWSDVVTLLVQVAGGLMKISSDVATLGHYIGLIGIGLQLFSYIIYTSLLRRCQRSCPSLKQDEAGCGRSAIHLFRVLWLSSVFIIIRLLYRIIELAPGPDSRISASQACFYLLDALPLVFALAPYTLAWPSRVFPAISFRGRPPIPSGEDTISKLPLTHNPYQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VES7</accession>
    <name>W3VES7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45228"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45900"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="ChEBI" id="CHEBI:85489"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VES7"/>
    <dbReference type="HOGENOM" id="CLU_009834_3_1_1"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000049">
        <property type="entry name" value="Enoyl-CoA delta isomerase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35502" checksum="C1C33D9E8A9EE2DC" modified="2014-03-19" version="1">MSRTLLALPALRSIKPIISRNLARATVSPRHLSVRHSSTRNPFDLSKVPRYDPTRPSKMQSYTQSFPSDSDALVKLSFDGESRIFTLTMLGAETPDNRLTHRLLGEGLLPAITHVEGKWNAMLDSGESDQGAALITTGGTDASAKIFSNGLDLEKALADPHFFDRCLNAVYEKLLTFPIPTIAAVNGHAFAAGFGLACAHDYRVMNAKRGYLCMNEIDFGAPLPAGLQQALASKIDDQKTMRKIVLEGHRFSAKEAQEAGFVDVLSESPQDTMDKAVELANKLKGKAKMNAWGANKEVIYAQAVKIMRTKHDDATTAIFAPRAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEW6</accession>
    <name>W3VEW6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEW6"/>
    <dbReference type="HOGENOM" id="CLU_973597_0_0_1"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF85">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30945" checksum="961A221A44ECA778" modified="2014-03-19" version="1">MSKLLRNGIPRTEDGKIDFSWKNHYGFTGLIVLLGFLFPPLAVAVRFGIGRDFFINVLLTICGIIPGHLHNWFIQNVRNNDTKARTPRWAIRYGLVDDRPQKKLDKKRAWTGRFNDRLPPSQRVVYDDEGVAHVVEEPQPDSDMRGVTAPWNTQPLQGQRTGLVEPDQWINKDPSQPEINYNHQPVEKRSKLARFSRSKPARTPDAQLDSDAQQLDRSRRRSSLATSSDESFIISTPEQPTRATFESSAASAKHLHQQPRRQDDIFAHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF05</accession>
    <name>W3VF05_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF05"/>
    <dbReference type="HOGENOM" id="CLU_479138_0_0_1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="34"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="552" mass="59548" checksum="F5A684B810F136EC" modified="2014-03-19" version="1">MSLAASASANAASLAAAATVARPSSPLPSTNSLRILLVDDNHINLSVLSTLLKRRFGHALAKPPVSLDSGLKALQMLRTQIFDLIFMDIEMPYLNGVECTRRIRAGEDGILAANRGAHIVAVTTNVGPEPAALYRHTGMDGMISKPVRFQNFQQYLCPLSIEASEARGSVTPVLVGTEEVMPPLPPIDLEQRLFFIPTDSGGTVTTSRHGIDRDEPSAEYSDANSFAAMLKAQTSKSLRDRKALSVSRSSTLSEPRRSSFNSPRSEHLPNIRPVQQSTSADLARLVADEDNDGLYHEPKPAKSTDAGQAPHLSFQSLIERETRDRERDDTIERRAPLPIRPTPVHRISSPAYLLDASPIARLRADPAMRSNPDLVPQIKRRPDIRPLPPKRLRRDDPSDESWSGTADSALDSASGGNTTSSSSAWSSTPMFSEDGAMSRQLGAFDALGSLSHRRGSSPSSGITTPSSSPADMGLQNYDSGDAKDDDLAGAIYSPCADDLLSPRTRELGFVPPLLSLNTKAASIQNRPRILVRTDSDKAQLGLGMDELHLGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFE7</accession>
    <name>W3VFE7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFE7"/>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="12"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="340" mass="36965" checksum="66EE574531E25938" modified="2014-03-19" version="1">MTTVNLGTVFKGSSSGKVVKAQGADRTVNARDVVIDITHSGLCFTDIHYLKKDMVIGHEGVGVVSQVGAGVKNFKKGDRVGWGYNHASCGTCKFCKKGRDTNCYENKMYGNADLDQASFGDRFVVTEEFCHKIPDGLELKHAAPLQCGGATVFGAMHDAGIQPYDRVGVIGIGGLGHLAIQFLNKMGCDVVVFSGSENKKDEAIKLGAHEFVAAKNNPKLEGVKPVDFLMVTTSAQPDWKTYLKVLEKDATIIPLSVDSDDFVFPYMPIVGKQLKIQGSLVATREVHEKMLLFAARHAIKPIIEEVPMTEEGINGAIERLKNGDVRYRFVAVNSKTQANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFI0</accession>
    <name>W3VFI0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_05615</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFI0"/>
    <dbReference type="HOGENOM" id="CLU_025113_4_2_1"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="17">
        <location>
            <begin position="50"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="117"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS60408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="620" mass="67946" checksum="2ED183105302EE48" modified="2014-03-19" version="1">MSLLRSCIRPAFRTVAASPSRSFTNKQVPPEQLLKYLRSGSPTMSDADNKIASLQAARAEQDDKVQQLRAANTEPATLKAEIGKLKKLEAQLAQLGIGAKAGSSKQEVKFTLKTPKGTRDWEPLAMSLRKRIFSTIEDVFSAHGAVTIDTPVFELKEILSGKYGEDSKLIYDLQDQGGELCSLRYDLTVPFARFVAMNPSEHGNIKRYHIAKVYRRDQPAMSKGRFREFYQCDIDIAGVYDPMVPDSEVLCILVEALDALGIEGFTIKINHRKILDGIFDICGVPADKIRTISSAVDKLDKSPWSEVKREMTVDKGLAEDVADRIGEYVKLKGGRDLLEKLKADAVMSGHATASQGVKDMELLFDYLDVYGISDRMSFDLSLARGLDYYTGLIYEAVTAASAPPGFSGDAAAAQDKAPEKKTKKKKPADGEEEVDESTVGVGSIAAGGRYDNLVGMFSGSKKPDAVPCVGVSIGVERVFAIMMQRLREKEARGERTSVRSKEVDVYVMSVGEGLLKERMQVAKMLWDAGIKAEFMHKAKPKLPQQFGVVDKEGIPFAVILAPNEWNADARQVRVKQQKGKDSDEGQGQGEVVNLDQLIKHLKALGAGTGSIALADRQSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFK0</accession>
    <name>W3VFK0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFK0"/>
    <dbReference type="HOGENOM" id="CLU_020800_0_0_1"/>
    <dbReference type="OrthoDB" id="2556725at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="345"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="512" mass="50797" checksum="92FCBB0163CC1D0A" modified="2014-03-19" version="1">MAAPVNDTAPAPAPAPAPDSPPPSTPPKQIAGVPRSPQSNNAAAGTGTGTGTDTTGSAASPANGAANASNPNSDTRLTTSSTTTSTPSSTTTSSTPSSTSTTSSIPSTTSTSSSAAPTTSSTIPSTSSALPTTSSSIASITSASATSSTPIPVVTVTYTSTGTDGAVVTGVSTSSNPSATSGRSSGSSSGSSPNLGAIIGGVAGGVAGLIILVWLILLPLRKRAKKAKEVEWLTFGQENDHVNESSAEAVYGRGAGGGSGEGKVGGSVANVNEIQMDDMAHEMAQQPYHYQNVDNGAGWAAAGAAGAAGAAGAGAYAHGQHDQYGNAHDGYDAYYHTQQQGYGGPQYQQYGMQPHQGWAGQPQGAYPPEAWGAAPGYTSPVQSQTHGNAGLQHSLSVGSTTVGGAPRNASAGGGSQSGHAKGSQEGHGGSQYGGGYASPPLGAQSPQQFPQHYQGHAAASSPPQHAQYYHGQQQPQQHDQQQAYYADQQQHDQRSGSPASGHGAGGLHLANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFK4</accession>
    <name>W3VFK4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFK4"/>
    <dbReference type="HOGENOM" id="CLU_288718_0_0_1"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1069" mass="113071" checksum="296FC1C98F85FA67" modified="2014-03-19" version="1">MALSLVIDDTSLVLILVLVAALAASIYVSRSYQPLIHPLILTRQADVSQTRQPNESAIYRNANSPAGFDLALRPRKEINDIADLIKHGANGSERNAQRAIYASVKSNQQVAADATSFATGFIKLSSAPVPQTVLAVAAESDSYESIVALLSNAHTSVSSRYNTVVLPPNQLESASPASLPQALASKGARSAIGVYTTAKSIRAVLQLPLLDSSALIIVPDADLQEATRLVADHFGASHRLRLYAYDAVLAAGSPGSLLGPDTSSRDVIEHTQSHYWNATSSDWLDVKHSHLVAGVTSNLAAFPADKIPNTNDHIFVEACAALDSPASKLMATRTPLGFALALTALYTGAALSADLPTSSYDDPNPAASAAFARAQPTLVYATAEGASSLACALASCTRRSPLASWAATNKLFTLRNGSFARNGLADTLVYNSARSAVGCSRVRTLMIAGRGDTVPQALLDSLRAHLGCAVLNAYVPQLNNAAVTAPVSVTHAFDLQAFAEHETAAMQVPAHVGPPSVAAEVKLLQTRIASDAGLAIAGDKPAGQAGDPMGEVHVRGNVVAHFSQAAEVDPETWSATGDLAAFRSNGTLVVLRDADDAEVAGVPTLSSRKPVRRQRRTATAGAKTVLTAALVLAVSLSPTASAGVLHKRGSSVNNTMSDMARMGMLAGQRASWEQGVSQAALLELDFPGWSVFSSSSGGPPYRPGLNRGASGPPNEVIGMAYHSASRQDSLGRLAFRITGDEQLGTGSSLDGASPGPEVLLAAWLDGEIDRQTGAMGSGFYADSARATLDMVLRRAPRSRAGAISHRLQYVALWSDAMYMMPPYLAFYGLVTRNNTLLQLAYDQIRLYRDGMRLTSGAATNLWGHIYLPDNRTWTDGGAWATGNGWVLAGMARTLATIEQSQASQAMVSQKNDLVSWMNEILDAAYPLLDERALLFHNYMSDRSTFFDTAGTALIAYATYRLASLAPGNDKWVGQADLIYRSLATALNPIGQFRDGYPVADVLAFVRQGDTSSESLAFMMLMNAAKRDYANNDVVRITDAQGKSNAAPVLAPKLVAAAVVPLLVLLCTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFL8</accession>
    <name>W3VFL8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_06541</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242898_0_0_1"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="1376"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="358"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="541"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="918"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1129"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1187"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="920"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1129"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1216"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS59617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1725" mass="186696" checksum="B8E94A2ACCBC4479" modified="2014-03-19" version="1">MSSPDGVHPDKASDQPTRGASSPPAGLLDLDLDELSPLPPAEGFANSRSASTDRLASLQHDANSQSRRPNAAAPSPALSAVSSSFRLEGSPVVAASSTPSKTPPSHAKNASQSPLAKPRSEPTRHQHQSHQSHQYNTRKTSFEAAEAPPARYVTVSAILSRSEMYYPPEASEHWNILRSPEGMPADATRSKLQSSWPTALGQQHNGTHRRKSQRKRPSNGSAIEALGALLLRKDSSGRVATLSFARKDKEGVTQKHGATTPGNDARAPTSKHSIQSWANALGSLGKTGLRLQLPQDSANKIQPSKQGSTIAERRAHMWHQVLTRQGAVVEHGHGGFSKVRSRRGGLTFEVGNVHRKETSATLLDAETYRPSRPAAQGPAADEDEEPRTANGGPASSDPSSRNDFGRLPGTIMLKAGRRPRLNQSSKSEFGIGSAYHDADLPEAPPSPVAMPGAWQGGSSWRSKPGDGYEEGALLLPPPLLDDHGSDATSFEGLLGVKRMREREKARKQAERLAARNRPAHKVGPLTALANFVKAAHAAETSAKRTRGTARQQPPAFFRSFTEPQLRRPQRSASIVSATGETTAKPSLATASVTTEDAQADKARAMEPDITLNGNTAECLPATPTIADADLRKSPAVAAASPFLSPAARRAVLSRRGSRTNSVDAAGRQLNTVFEFEPLDPAQIPDDELASPDLPPISSPLLRPSSAGSSKASVREFPVAPRLLPVQLSMPPSPFTPLAIDPRGDYLSARSLHSAPRTPQLGPTMLSLPPSPWTPYQDAAAGTASPMIHLRLNTSTTSLRTAPGTPRLVPTHLEIIPSPFPTSAASRRGSLTYDSPHSLRAIGFAKSPLAQAIADPASSDADVAQKMVVLTEETAAKKTSQFANGVDTLRLTPSSMLIEAQSIHSPNAQINAANALAETPGTHQASGTNVEEQNAQECETESRSQRPTRSRQNTVHVDSAGRQRSFVLWFLIGDLGLRNRPSADKAGDSNVEADYGGVVAVLVHTVGLVVFVTAHLVDLAYSTYERVSLILWFLRWMVYNLAGRTVLAQCVVEAYGFIQVEWATVAMEDHEEKGSKKATDAEGHRKPKGLSRWQVLRGLLELYCLHSVTRERYLAEGAGLQKLEGWARPVNRDRQDSTEGKKRTNLQRGSERLDIGAHRAASRAALGEKRSEWAQHDADIMGQLDGTFKESSSLAQPEKRNSYAVDEANEGTPHDDGEADDSSDDDDEEMIVTNRGDDILEFAKTPRLDPARPDHASSGYFGRAYDFMTSPQVGASHPGAVQRDLRPFKETNRDLVRTIKWCGRLAISAYGLHVHIVDLPPTFTPSGERFSRQTFAYLSRLNADDVLHADIQTLDADADYSPTFYVVRDYVRKVVCVAVRGTQSFSDIIVDLELQTEEIELPQVQPTPGEEFRCHAGIWRAAKALVSPQSKLFATLRQALAENDGFGVMFCGHSLGGAIASAAALLLAEYFIPDGAEPDQGTWVTNMSSGLPARRPIRAVSFASPVTMTADLASRAALGSVPLVTTVVLGSDVIPRVGHGQVRELRRVLGALARVRRRHAMASSEGQEDAQVHILRSYWDWRSISQAEDPDDVMLHRKERIEEQLWSLRREVESDLYAAIKARLDGGSSAGARIPPSPWVGPQQREQAPLHALATRRQELDSATLRSEAAQGGPLVPPGRCVWIEGGQLYAVQSPLAFFSLPELRDDMFAAHFPAAYEEAILDLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFP9</accession>
    <name>W3VFP9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFP9"/>
    <dbReference type="HOGENOM" id="CLU_014282_0_0_1"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="296"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="930" mass="100008" checksum="BA8EC1593DBBA4AD" modified="2014-03-19" version="1">MQQRSSLLSSHHLHHHHHHHRDIHIPRRRIAPSANAARITFAMAAVAPATSLLNSYASPPNTDASMSNTRKIFGRSRKHAQPSPAPPNTASYDMTDEKVFSSHDSNLSTSALSSASTASRTSRFFRRFGRRKPPPVPSLPPALVLDLDAGTAAPRASDPSSPVATRRPIAAGQPSAAAAIIAESNAAYAAAETRPKPKGLQRKRMLDAMANARLDVHHARDLVRMCGLHIRERGLDTPGLFRPFRIAESHDQVLHMIQLFLLSIHPSTYMAVFPILPDDALDRFGRNATAPAADHNAKASVARDELDKELRYAAPHDVVAVMKWGLRHLRLRCADFDSKDADEWYDGFAAAERAAAYPARAIADLLHPKLPIATAELLSETLDLMASVAAHSSTNHMPAAQICKVLGFWLFGRIGVAHPPPTVDELVDAVNRAAGVAEHLLLAHIRSQAAVTFSMPLRLTELVQNYPHVRPGAQCPSLPAVFAARAVPTLRIDLRSDNMVVSQSKPRTPSATLADALDAQAADTIQGEHGELWAAVMMQLDHHDASTNASRLLIDEHVRILGLVDKELAVGEEDTNASLASAAAAAATPHGVLADDNKVGAQIKAARRRSQSLSDLRTNLGMVGAAQLAPLPENVPRSSTGTATPRSSDVKLGTPRRKPVPLVDAKLLQEAEAVEVPVPLVDAKLLQEAEAVEVVDEATAPAMRASDEVFSGGLEPSASWRSFSEEGFGGMSTASSELSLSEFDLRPVSATLPSRRSQRGLHRVRSSASGGSRRRTVLPPVPLTSAHVQAHHTVTAARMVEHDTALAIVWQDQLLDASPCCSLPAMLFVQLSKATGAAVAAVQDADEADVPRYPGDTPWLLVVETIIPPRPPTPPAVGKASWRFDDSASTSDRRSIFAPSMRSVKMRLRRVSTIIGNGVAGTRKKHIDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFT2</accession>
    <name>W3VFT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003349_0_0_1"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="3">
        <location>
            <begin position="356"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1299"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1312"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1347"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1409" mass="151946" checksum="90480FAB2821EF5A" modified="2014-03-19" version="1">MARTTTRKAGGAAKPAPQREASNDMVDSDGSLTEPSSEGENSESEVESSEEEIEEDDDENDGDFGSSRKKAAPRRSAGGAAPRSRQSNTTPRARKSAGTAKTPRSGSKRSGPSRPRAGTSAATPSAARSRAAASRDELPINDDNEIFVAVKDPNSALQSIAEDWVVAFSDNEASALADLVNFIIRACGCNGSVDENQVVDIDNVVDNLEELQEAFKKQPIPSYPIVSRSKTFKSFRKSLNDFLHRLVMSAYDAEILTADGFMEPYQAWVSAMSSSSLRSFRHTATVIALWTISALSEVGAQATKDLATATKQRDAEKKKARTDKSRLKDLESKLVESRKLKARLEEYINEFINSVFVHRFRDFDAGIRSECVSALGSWMKKHPSQYLQSSYFRYIGWVLSDVDASVRMAAVQAMTGLYTGGNFVSSVRHFTEMFKARLVQMATGDVELGVRIATINVLAVIDKHDLLEDEQRDLLATHIFDVEPSIRTAVAGFLANILDEMVSEGASELGSLSAASKKKGKQAEEMQHEKAKLRFKCLAELLVKYGHRLDAAAGAAESDAAEGLGVVIHGAKEGRVGMAVEALWGAVDELQHWKALLDLLLLDHSDKAAAGGNKIAENAAPAVYRLDTDEEAVLVEALAAILRRTLAGAEAIDDAEDTTKEDVSRASIAALPKLFAKYRTDAPRIADLLLIPQVLDLEMYTELQETTAFEALWDDVSSQVQRHVEPLVLKHGVQTLQKLMATTSQSNVNSTQLSALEEALVSSLRETVSDRDVETAGFSEDEVHLLAANMLRLHLVSQVANTSDALEDDEGGQATSGWEIVLGIASRGRLAYKEEESLVRDAIATLALYIMWKTRQVILPEAGSQMALAEALLAKRTPVLSLLEEFVASTQSQACIGVQRVAFEKIATIHMLYAAIPQQTPAAATADDASVGQADEDPAARLRAGPQLPALLNLQCHADLQQHCAHFVKAEIERYIEKSGVLEKEANGHNDAVHDSSDEEAANGNHNEDQDEEDDEDVEATPKASRVRGGKSKKAKKVASAGKASNGAGAHSERPNEAQLQAEHTFCSVISTFVAAIRVGVIDAKHSTVVLIHFGRLGAIYDSCCKALVEVLKEEAIFGGYNRAVIVESCIWDSLREAFELYLDGGDAGSEARFVSLSRQLANALVVRGAGFTALRKIDARCLISLHSRASEHIAQKVAAAERNGDKRVKQKMPALYKGMANLLMTATPTDAVKIKSAMDRAFRAANVQVPSAAKAWDAHRSYEKRLLKIAAKSALFAPAAAASGKKDSGAARKGAAAAAKSGELSDSGGELTDDDAAEDDGLPANGSRVLPTPVRSSQKRDRAEAEGGEEEEESDNEMDDHPVVGSEMADLDVDMPASEAGSLRLDLDDDGDDEAAAGDASRRKRIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFU3</accession>
    <name>W3VFU3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFU3"/>
    <dbReference type="HOGENOM" id="CLU_090028_0_1_1"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000122">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="60"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="173" mass="19320" checksum="4544867CD60D531B" modified="2014-03-19" version="1">MSSQWEIRFSNSRRLPYFYDPVTQQSTWEIPEGHTDESIRSLPGAQYLDPANAPGAPEKPDKVRASHLLIKHAGSRRPSSWKEANITRSREDAIEQLKKFEQQLKQDPAKDNFASLASVHSDCSSARAGGDLGFFQRGQMQKPFEDAAFGLKVGELSSIVDTDSGVHLIYRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGC1</accession>
    <name>W3VGC1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGC1"/>
    <dbReference type="HOGENOM" id="CLU_1845960_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="139" mass="14981" checksum="4A20B486E099B254" modified="2014-03-19" version="1">MAAANLEMWQRASPPPAKSTEVPRKTISENRDSLGPPAARSDAMPAAQARALLSPSSAPGSPRCSTYVVNAAMLLGPIQSRLPVCNGSYRTLHRSHVPGCEQQHDHEPPPSVHSLQSRPTNQLRKRAHTSSHVGHPNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGD2</accession>
    <name>W3VGD2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_05438</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGD2"/>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="99"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS60585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="497" mass="54325" checksum="9D1DBB8AA0214DDE" modified="2014-03-19" version="1">MLKFDEVQKHNSRESCWVVVHGNAYDVTEFLPDHPGGAGIILKYAGKDATEEYDPIHPPGTLEENLPKEKCLGPVDPSTIKKEEKVEKKQVAKDDGGVPPLSQCLNLYDFEVIAKRVLKPTAWAYYSSGADDEVTMRENTSAFGRIWFRPRILRDVSKVDYSTSLLGQKSTLPVYITATALGKLGHPDGEKNLTVAAGKEGVIQMIPTLASCSFDEIVAAKTHDAQVQFMQLYVNSNRAITENIIAKAEKAGIKGLFVTVDAPQLGRREKDMRMKFDDVGSDMQNQNKDNVDRSQGAARAISSFIDPSLSWDDLTWLRSVTKMPIVLKGVQTWEDAVRAAELGLSGVVLSNHGGRQLDFARSGIEVLGEVVEALKAKGLFPNPMFQIFVDGGIRRASDVLKAVAMGATAVGIGRPFLYAYSAYGSDGVVHALQLLKAEMEMNMRLLGAPTLKDVVPEMVDARALGTHVNFTPVSHGHQIYEKLQTAVGMPGEPANKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGI1</accession>
    <name>W3VGI1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04649</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGI1"/>
    <dbReference type="HOGENOM" id="CLU_057172_0_0_1"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="258"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="89"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="380" mass="40594" checksum="ABF480656A6B3CEF" modified="2014-03-19" version="1">MAFYSAGPLSPGYNSTSAWGGNDNADEDPWAAPGASSSSTPAAVPASGSAGGFTSFSTQHQQQSNRAQGGFGANSYFGASLAQEADAYGDGAMDAGFGSAAQPGPRMQRADSGFGAAQNQHSNAQSSPSTYGSAISSIDQAPTQRAPTDQQQRQPTSPTAPTPSNSAFPSGVQVGTNQTSGASRFQSHTPSTLLPNEPAGFSSAAAGEYGAAPRQLAPGYPLPASNYTIPAYSPFARVDSLSTPRREAVEDMYGVPENFLEVEVRNPLTHGVGRKMYTDYEIVTRTNIPAFKLRYSSVRRRYSDFEYFRDILERESTRVNIPPLPGKVFTNRFTDEVIESRREGLERFLQVVAGHPLLQTGSKVMAAFLQDSAWSKDQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGJ8</accession>
    <name>W3VGJ8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_06163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGJ8"/>
    <dbReference type="HOGENOM" id="CLU_011310_3_2_1"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="83"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="350"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="463"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="627" mass="68418" checksum="5DC4F1769649AB60" modified="2014-03-19" version="1">MMPQRTLPASRLANGMAASSNPSRAHSFVKLAIVALTAVLHLIVPVLAAPFSSASTLSLNAPNQQAYSASRHNHEEDDPVSDNPFKLAIDILTIAALVVLGGIFAGLTLGLMGLDMVNLQVLASSGSEKERKHASKVLKLLEKGRHWVLVVLLLGNVIVNETLPVFLSDFGGGIAAVLTSTFLIVVFGEIVPQSICARYGLAIGAFCAPMVHATMIILAPIAWPTAKLLDWCLGEEHGTTYRKAELKTFVSLHQQIGTEHLHEDEVTIIRAVLELNDKTVRDVMTPIEDVFIMSSDTILDDDGVAKLVKSGYSRVPIHEPGKKDAIVGMLLVKNLIQYDPEDAQAVSSFHLTPLPEASTDLTLLDCLNYFQQGRSHMILVSTHPGESRGALGVVTLEDVIEEMIGEEIVDETDIYVDVHNKIKVVRNRQTNNTPGQNWQPLIRGIIERRRKLGGPMKAPLRSSYGTVGIMDHDGSGKTDRKYGVPSTSVRAVDKVAIKRPGSPQSMASASRKNSGTYEPNAPLRRTSTSSVVTSIDGLNYQDLHRAVVQQGTASGQNSYSEPYIVEVGSQDRQPHIVRISDIQEYPGAEERARKDDERRNQQNGGEGAQQDDSIEEGERRPLLDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGR4</accession>
    <name>W3VGR4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245301_0_0_1"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1557" mass="164289" checksum="587735BDC843B304" modified="2014-03-19" version="1">MPFSWTTDRAAAPPNASAAPSGRISASPQTRPSGHRRGLPHSSSISSRHSIVSTEARTAAALAAPHSLSVPKSASSAALTSTDESDDFRRFLDEAHATDQAARSLGAHPPQRAAAGAAESLRRVTSSSTLNSMHDQRVAQPARPATSAAPVGRVRKNSTLSTASRAQRSVSNYSMNFRNPTSQFLEHLSAEAQTPELGIDDTPVAGRAVDNKSHLTALGHAAQLQTRTASGSHSTKISSAKGKAPAHQVPVRSPTVPIATATPSPSVRIKPSVSGNAAASASASGSGSARSPPSNQTSQSPGTSPTARLSPLSPRRRPQSYIHKPPSEPSGVVSPRRLGESRLGHGLPTASPIQAKRSADEMERSSSLQPTSQPSEQPQAAIPASPSQASRRKTWFGLGWAAEDQPAPVEADKANLEAAEAADAAGSASDQPPPPMSEEEAAFRRSLGYNDVYDPAADKQPSAGGDAEQKPFPAGRDSDATIRAAQIPARDRRISWIPWRNVSAAAEQGSQDAASSSADTPAHQVQQPQPDASASKTEAPVTSEASESVGTQEMRSSASRQDGQDTVTYKTVVKRGWMGARYEVQEPVPSLQHAFDPPQVKDDTDLAAASSKPMEQDTDAAAAQDLSAYPPASTNASDSRQTSGTWRWRFWSGADGSTYGDQAPAAQELVVSSEPPPTDPAGSTRVATEPDTAEPMDIDQNGPPDDAPHNADSASWTYSSYVSRWVPTWVYNAQQQDSATKDVEGPSDQTSEAVADKANTIDAAAQTRTPAEQVKAEALARDASVVALTPSKVVLNNSTKSGWINFFGSRSANLPREAPEAIGNNDGVEVMDISDMDAPVQSTSARDVALRNGRLTPDVARAPRARTVTGGSLAGSKASSFASESDMQRAATPLSTSKDSVRNLSKAAITKAANVTAASTLGLGKGKRTDAPTSTSTASGTGEPSAGSQASKDAGKGLAPNGSGPSRSGASTPTKSVADPVSAPPPNLVLPSFDDTFTRAPRMWPPKVGVLERTLSAVNSYLFSKVPDLERMKRPTRYSTYGDSSLGSNSATFKGAVASLGGKKPAQRLAGKAKASGRGSSLDKGVETALKEVAESAQRLPRAWFTVGMHDRAQTRGTAAIGKIVVIGVHGWFTQSIFKNMIGEPTGTSAKFAAMQTESIRRHFLEAGLELNPEAITAISLQGDGRVADRVDRLFAELISRPKWVEDLKSADALFLSAHSQGAIVATQLLARLIEQRHVRAEHTRICLLAMCGIHHGPFAHLKSSITASYINYFETAAAKELFEFQSSTTAVAQQYTAALKIVLDAGTKCVYIGSTDDNVVPVYSALNLCNNHPSILRALYIDGQAFPRVDFLTNLLVLCVAVRNAGLSDHNLLTLLSASVAGSLYGGRGHSQVYEEKAVYDLATRYLFEVTHPLAEPTFAPGPPGATSSSLSTSTNPGKRPSTAESETSKAALVSEAFEAQRWNPYELPWALRGLFEDKHVRSLFAEDMLNLLESYEQWRPDPKSKALKDLQWRLAPMRSIKPPPIQDGEADAGASTTKAEEAAGGETGSSKNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGX4</accession>
    <name>W3VGX4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGX4"/>
    <dbReference type="HOGENOM" id="CLU_087056_1_1_1"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="140" mass="15504" checksum="7C033EF66C54BEB0" modified="2014-03-19" version="1">MSGSSTIDIPRNVLDAVRKFRLKPSSHLTALVFKIDKATLTLGLEETLDSGLTSLPDLLEELPENSPRFVVVNYKLNHRDGRISYPLFLLYWAPQTSSLEQSTLYASALSNFSVQADVAKVIDVRDPDVSPESIDQRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGZ1</accession>
    <name>W3VGZ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGZ1"/>
    <dbReference type="HOGENOM" id="CLU_023804_2_0_1"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="511" mass="53092" checksum="087711C64C0344B8" modified="2014-03-19" version="1">MAFSFGTPAASQPAASSSGTSGFSFGQTPAQQQQQNKPASGGFSFGTPASQPQAQVGAPAAPATSSGGLFGGFGSSQPAAAASSNAAAPGTQAAASTGGLFSFGAKPAGLTTSQPQQQPAAGATSTFGSGTGGLFGSTNTQTNTAGSGFSFGAQNNTASQPQQRQQQSTTSLFGAPASSFATTSAQQPVAQTQFSAQPQQQQQGMAAQPDKKLGVSLSAKLEQIRAAWDTNNAAGCRFAYYFYNNAGNAQNLKMIQGRRPDAIGPMHDQLWTAAVRENPDPNRLYPVLALGFNDLKKRIESQAREAQRQRALLATLAQRLSALEQKHSLSNSVRTQAAQSRQAQLHHRLIGLAAKTQLLIPVLRGKSISPEEERLMAVLEACEAEITGSSNALASRSLALTPASNGGAASSGSAGMHATPVQHARLRARINELWAQLGVIRARREMLAREGRSATTEWAVVDQSGLDNVTRILAQQQQGLNHLSSTLEADTKTMDTITTGLTGVKLVGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH22</accession>
    <name>W3VH22_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_06092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH22"/>
    <dbReference type="HOGENOM" id="CLU_1587213_0_0_1"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="168" mass="18893" checksum="DF4A7C08F09769AA" modified="2014-03-19" version="1">MASGSKYEELIAEDVAYHKASTPLEDMPSCTNMFDKWAQCFALGPQIKAVYRYGGLQDCRDKLDDFKFCLTMKGMSPEEKYETWIRRKAEKTASQRLGRESSENVWQIRRETRTNAASNPPSIFRPPLLGLTLTRASIPPAFFGEMAGWAQWGRLDLGSGSATGALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHC2</accession>
    <name>W3VHC2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxamine 5'-phosphate oxidase putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHC2"/>
    <dbReference type="HOGENOM" id="CLU_054794_2_1_1"/>
    <dbReference type="OrthoDB" id="539398at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF3">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33979" checksum="A0E00C2EB2B42097" modified="2014-03-19" version="1">MGKFYDHIPEHLHEFMLRQRLFFVATAPLHGGSVNVSPKANEGAFEVTSTHRVRYADLTGSGNETISHLLEPGNGRITLAFINIEEGAPNIVRLYGKGTVFERATDAGFDQKWRDEHGGKPVPIGLRAIIDVAVHTCATSCGYSLPVFHFQRKRTVLDDYHSRYDRPGGMEALQKYKGATSPSVDAEGIVVEKGHDGGPRVRRLGSALELYWAICNTLSIDGLPGMRSVAPLTNKEEQQRLLIRAKEHDAWQAPPDDLRPIRSPPMTSSQTGKRAAPGGNVNLAQPVNMLHVSIAFAAGCALTATLLATHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHL9</accession>
    <name>W3VHL9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_05823</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHL9"/>
    <dbReference type="HOGENOM" id="CLU_012079_3_0_1"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="13">
        <location>
            <begin position="65"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="685" mass="74677" checksum="DB6ACEE366DBCA26" modified="2014-03-19" version="1">MLLWVVLVAFCFALIPLVGALALCIYVAAYHSSSTRPASSGCLGRSAAVVVLGDIGRSPRMCLHVESLANEGWKVAIVGYPGSSLPPALRRPSVRQHHLRTPPSWIARLPRTAFIAVAPFKLALQALSLFTELTTQVRPPPEVILVQTPPALPTLLVVKAAAKLVNARAIIDWHNLAYTILALRLGAKSRLVRLAEWLERWSGRKAYAHLFVTHAMRNHLDLEWKLHGHKAVLHDRPPAHFRRATVEETHRLMAKLVPQLQPPLGDEFMLEYSVPVSTPFTRDDGAAGEASVQWRPDRPALVVSSTSWTADEDFGLLLRAARLYEFRARALAESSPTRGSPAHSRSSTGDNTLSPITPSSPAPFSSDGETVRTSKERRRPSLGALRSATLPHEPASTLPKLVIIVTGKGELRARYLAEIARLEQQERWRWVRIRTAWLETQDYPVLLGGADIGVSLHTSSSGLDLPMKVVDMLGCGLPVCALDFACLDELVRDRSNGLIFRDAEGLARQWESLLAHHPQPNWLATGTGMQEPFEASTAPSPGGLLEPRVGAAVPMSPNPSMTLLHSPGLPPELNAGRGPRSTWSGNWKHVMRPLLDPAVSDQEVEAVLHSSALKLDSVGGILQRRVKQGYTRAPSTDAGAFQFVSQAAAITHESQKGLRLRKSVSSRTADDAIPAIQVSKPPTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHN6</accession>
    <name>W3VHN6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHN6"/>
    <dbReference type="HOGENOM" id="CLU_002075_0_0_1"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="62"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1194" mass="129402" checksum="75C063A8B003DFF2" modified="2014-03-19" version="1">MSALPSSSQQAANGASASASSPNKTKDLFNAALQARNPNNAYIAHLKIWEEVPQEAAPDAAPAKKARYLILAVQKDTGRVTINKAKRNANGSFSIGKDWDLNTLREVHVLQPDVFSITLTRPYQWQTQQPVEQQLFLQSLVKVYRKYTQDDGPRLVGIHVPSASASTPAAAAVADSANLSDHPSGYRSDTSQLSSNNGTVSSAVAIPIVKTSSLPKPRIDTAASPTRSLSSEGSPVNGRDKSASSLGSNTSPNPLKSRREGTLQPSPLSRTAQLPSRPSAESDRSAVSDSNSYRHPTDSKSLAVPTQPPPRKNSADSLSIRSGSHGGLAGGGGDARARLSSIEPIRGGAAYERMLLAGTGLNGVTEVDDDGAADDDDDPYGGAVLADNDAAAPDASFSSKRATLGRPAIARLEMPDKNAARQRAKSGDRVDEDEDEDENSTLVAVEEMLEGFEWRNGGAKGYGTAAGKGTADMIEARLLDELSALESANIHAIIESDDRVALVVKHMEEALAELDMMDSMIAGFKVQLNARADDISHIESQNRGLQVQTSNQRTLMGEIENLINTINVDEDAIHTLSAGRLESSEGVAQLEMAAASLYKSMLQARRDGDGGGADMAAAAERLADHEAISSRFCKRILDYLNVTFSAESQRLLSDPNRQKALQPPHPTLPDHAPMEEALGQYCGLLLYMKEVSSATFSRVSASYFASASECYRTEMQQLFVAYRKQLRKASDDDINESSFTGSQSTGTATSAIRSGTIRRVQRDKSARGGRDRGDVTGQDGLQRILSSIIPILLREQSFISDLLHINDNNITFADYMDLEPYFRRRAAGMFTGSAGPLREMKGAMDLIFGFMAPELQAFTDDALSKDKMSIVGLLATLDRGIIEAEEVNCESLQKVLAKLHLRLASQLERFVQEQIKGIEQTKLTVKKRKGVVPFMRIFPVFVERVESQLLNAETLNIRHAVDGYYAQICGAMFDALQTISRVETGAGAAGDEDKGQLNHLVILIENMYYFIHEINRASRQRGNSALAGLVKRAEAIYGDSLASYTQFVLRRPLAKMIDYGDGIDALLRSTPANEVSLHSAYSKSSFKKLVRDFTAKDTRKAIEALSKRVAKHFGDDDDALPVAAPAASAGTDSADAGQAEVLSRVWSSCELGYQREFERIQRIAAECYPDQSASLELGSNELRRLFASLAPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHV0</accession>
    <name>W3VHV0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHV0"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_1"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="39972" checksum="B004B136A21E96BB" modified="2014-03-19" version="1">MLAQTTRRGMARTVAPVPFTHVGLSRTAIPLAGPLRRTLASTSTSRSHENPLGLPRNNQRIPPTMPRRGGPPQPRRIPHVKHVVCVSSGKGGVGKSTISSNLAVALALTQLPGTRRLRVGLLDLDIFGPSVPKLMGLEGMGEAELTRDGALIPLTSHGVRCMSMGFLLGNTRADADGEEERVVAWRGMMVMKATQQLLFDVDWRQDPHAARTGGEEGGLDVLVIDMPPGTGDVALSLAQLVEVDAALVVTTPQEVALLDARKGVAMFRKTNVPVAGLVLNMSHFISPDTGRAFELFGDAAAVERYAEKQKIEVLARIPLQPHVSAGGDRGTPVTLRKTLESVDADGKTQVQDNLIRTAFLDLAQRVWTRLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHV3</accession>
    <name>W3VHV3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHV3"/>
    <dbReference type="HOGENOM" id="CLU_112150_0_0_1"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="217" mass="22814" checksum="897167AA9A463FC1" modified="2014-03-19" version="1">MVLGFGHHSQRDPNVKGEERGRDPFIATGRGGAGNIIRSPSRSRDRSGNAIPQQTAAAAAVPAHMISSGRGGAGNVRSPSRDPLDRKRAAEVQAREDKLQEEYRQQDLKAPHSTGRGGAGNIAADAEERGRGRGDSSNGGGGGGVSGLLRSLSRSRSREPRGGKESPKNRSQSRPRASESSKLAQVDESARSSEEESAYTHSTHTANNSNGHHPGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI73</accession>
    <name>W3VI73_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI73"/>
    <dbReference type="HOGENOM" id="CLU_017453_0_0_1"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="88912" checksum="9EA4660D91E31F4A" modified="2014-03-19" version="1">MARKPRPLVSATAAPLKTVHTYPTKNANISLHVFSYPQRVPTFMGGSANRGWGALSGSVDIQVTDASGDRISAIKLTLTATQTITIPKTASTDTPSVLDRMPIDPEETKTKEVILLQLETLLLEPPKNETDRDSDLLPQGRHAYPFTIDLPLVGNKDKKSPPLLPPSCVIEPLLVGPADAKMRQKAKANGKGPVRPAWATVKYQLKVTVQRPGLLKRNLRSYAPFVYLPLPAPAATSLLLNRRMLGAQMAAIVLQHQGDGRQPIETTGDWLTRPLPFLTSLNGPQKLEPERKSGFLSSLFGGPKKQSVVHWHEAWTLSMPMAPQACFPLRSAIPFVVRCATNKPIDLTVGSPLTFTLFRRVRLLTGKKQKPIAVQHEPVADAALRCSVESRGVFRLNGLLSLPPNCVPNFDLPSLALDYYLAVVRVLDGSVVHKESITLACPPPVEPKTAYGPYPSGLAWRSAQQAALQSRNVLPASDESPPLAPRSVAPASEYSSAVSGRQRPSISSMASSAGSSAYLQPQSRRTSEAPSLRSFRSASTDSAHFATAPSSVSHASAGANVGASMGLAGMTSPPPASSAGASGFVHAQSSGNLNAVREQAAVQPRTAAPVTREQKVRRASQPATEAAETTSIASSRTRSRYSSKGAAADSAISSARSSAELDRPIHIHVTEKGAAPGAQSTGRRALFVTNSDSLPSIPAKTASSMRQHADALVGEGSRTKQPRAKRKEPKSQRSSSSSPSTQPPPAASGSRRGSHASSSPNAAGQSRRAERPLLAAAPIPDPPAPVAAPPPPPTQSTPVDPAFLLTNDDLMYGEDMELDLPPSYFEAVYGAGEDEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIM7</accession>
    <name>W3VIM7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIM7"/>
    <dbReference type="HOGENOM" id="CLU_1402980_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="194" mass="20276" checksum="F6B83693600FC91B" modified="2014-03-19" version="1">MLVSTAKGTSDERRQADPVKQHEGYTGLKAPFGVQAVDGSIQHDNEIGEVSALSRITLFNIGDVSSGFATGVRGGAAVMFGGDFGSRIHGRFNTGPEEQTRPNPGPRQSTEALHAARGRPYSWLQQHTAAEGLGSHKRAQRPKLTGGPALLHSQNVAEASSALSDGSPATRNAKKLGSTTPSHCPRTALGSSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJR2</accession>
    <name>W3VJR2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04008</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001640_1_0_1"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="989"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1164"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1205"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1242"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1272"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1310"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1348"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="627"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1428"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1755" mass="188285" checksum="35E2059FA5ECAAB8" modified="2014-03-19" version="1">MTECAEAGSRSAQQGSALANPATGAASEFRSTAPATTNPVFRQPPSGTAPAPSAANLPRNLPMPLDARCVSTASSNHPALDRFGISPSLAFVLTIPGISSSQGENNGGMTTSAQPSHAPSGQSSAAIATPRKDERESSLASDVSLQRTRSSDAPSLSSSAIRWNQFGALTRKNWIVLRSYWLVNLLRCLIIPIAYYVFLGEAKNFFNTTNDLGLGQPVPVRRLSDGLRNPIYWLDSRTQTADSRFSAQQVIDVVLDSLRPEQRSLVRRVDSDSDLGLACPQAFNGLSSCFGAVEFSNISAQGSVAYTLRLDPGLNRVKVSTNSGDAERRTLPLQFAIDAAILQLNGAPASAYAQPPLEQPYSQQTNAQQAESQRRGFLGGVGQLTVLAFFIGMLGVVWHLPSSVSEERGSGMTALLTTMGCGQLPRLLSWLCGPGASYLPAWFVMGGTLSATLWTTSNKALCIFAHVLPGLAMASWSLFVATFFARANVSSIITTALAILFAIVALITKHIGEGGGIVIGLLFPSASFVYEFIAISAYEHEGLPADVTASRDGINKGPSILGQIIVQVIGIFLFPALTILLERKLFFSEPFFQWLFRRHRSQPSVPHQNGSDLSEKGTSTSSATPALKITDLTKKYGKKDSSLAVDGLDLEVARGSITCLLGSNGSGKSTTIGIVGGNIRKTSGEVYIDGYERGAAPPGVIGVCPQKDVLYNQLTCLQHVELFRAIKHRRGSKDDPEDLLTRCELAHKLKSKPFELSGGQKRRLQTAAALVGQSTFLMFDEATSGLDPLSRRAIWKILLNERGKRSILLTSHFLDEADLLGDHIVILAAPGKKLCEGTPIELKTSYGQGTTIHVSPRGRQVLPLLDEVAPGTRPIASIEPEQDSFLLPSTDQALVAKVLEAIESRKEALGVEGYDVAGPSLESVFLTLNSEHARLNGRQEEVDEMEGNVGHWSRVDAGAQSGLSDGSVSSILTLTLAQFSKRMVLYRRIYLPAIFAILVAVLGSIVPLAFFSDRDPSCTRGFADRELSFRATFWGNASAATELLYAAPEANAQTVFGNGFDLESIAFDRVPIEQYNATIARLWNENQRGLGGIALPGTAGAVNQFSYLADEGPETPIAALNLVSNAGLASVRSTTNSADGSPTITSSYRPLSNLSLGNGLGSSLKWAVVFGLVQAVWPAFAALYPSAERNNRVKAMALTNGMRAIPLWLGHLLAELPVIIISTVPVALVYAFASSQFAGEGVFWVVLFLHGVSSTLQSFVVSLYAPNQLAAFAIVAAWNVLAFLIYFATTMLTVTYYVGNGLAGALDAAYYVEAILAPSVSMTRAGFVSVNLFNLLCNGRGGYKSGGIGAIDLLGAPIVYTIAWALVCFAILIAHDSGVSLWPSWLGFARRSRRGKRNVHEEGKVQPTGQGVREEALRLDSPECDDVLQAKHLDKSYGKLLAVDDVSIGVRREETVALLGINGGGKTTTHALIRGELVPDSGSVVIAGISVAQQRTLARSHIASVPQFDGLDPLLTVEEHLRTYARIKGVEKRLRRDNVAAVMHLTNLSQYADRRAGALSGGNMRKLSLAIALLGNPSVLLLDELSSGVDSWTKRGLWQTLRRAGKGRATLLTSHSMEEAAALASRVAIQASRILAIDTIGNLRKSQPAYELQLDLAQEHRGSHEAYGRVERLVKQLFPHATSSDEASARFEIPLAEGQSVSSLFRKLEQASQEREQAGIVGYQISPVSLESLFLQIVRQAQSAAARDEIGRHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJW3</accession>
    <name>W3VJW3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJW3"/>
    <dbReference type="HOGENOM" id="CLU_293582_0_0_1"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833256" description="Pentacotripeptide-repeat region of PRORP domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="769"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="856"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1201" mass="132398" checksum="0A86DA6995430836" modified="2014-03-19" version="1">MVDRIPPRASSAAAGLVTLLRLHSTSAARPSSSRHFASVTSQASFQGTSTAPSARASSASIYGRSEIAFGNARSFASSSSAGVSAHRKQAGREKARQRAMRQEERVLRQREKEGYNAARSVPRRPRDPIDEDVEASIREYMARTGPRGERLTLAQQERLLKQELKGLGHDLERIEKKEAADKATQDLPELDDQTLDELYQALMLPPPPTPEEARLARLEGGRRERGLLDRIEDGRGRKRLDRLAGLALPPSTVEVKRERTARDLKQKLIHARERAKILLPPSKSTSQEASAVPLQAEAAREEVGEEISDVDFAALPFEERQEVRLQQLFARLALVQDGADAAGDASGSESLSAIKSGLAGRIARILKQHEYELHPSTQSARRHDDDLKQDSEVAEQADTHSPEFESVRLDRRATSLATGEAEAEPSEAIATLGEKSDVVARADAMIKDLGSAESRAFMLDGIERLVRSAKSATSSELASSGSQASHLPLGVATTEEWMAIAVSSARAEDDASLKRTLSLMEAARHPASLELYNNVLDVYASKGRVAECQEWLQRMTEAGLTPDDHTYHSLTKAYVTSAQFLPALELLNSLEQSGHPAAMATYTLVIDRLLDPVAIPRSGSAGVSSEERPELQALAWNVFYHMRLHAHPVPDAPLYALMIRACARGIAQPHEIDDPTKAYTALSSDASGRRHAPRISDAERALDLFREMTTRYNVRPNAEVYNSLILACARRKDFYLDTFRLLREMVELETERAHAADAEPSGMLRFAPDTYTFNALLQGCARNRDLARARWVLAEMIRTTMPLFDPEVRGTLSSQDVVELLAKRPNHETMCHIFHTYASYEPPLKRDHMQITRKTDSLTPEAQSAETQATPSPVESNKEPAAQTASTEVEPSSDETTPEEAASIFSALVPQTASDLVSEARSLFARILADQAQPSGDGKGRMEGPLGGVEPGVRVVNAYLTVLAAHLPVGVRARVLHSVFAAVPEHDEPTLEHGLFARLGVEPNEHSFRIVLEALSELPPDPATGADIVQDIWSRFERLFPQSDRVSSDLVKLPVAKGEGVDWTQVRKAWSAYIHFWAKNVSLASGDSKEAQPGLDYAMVLLRRYASLYPPRVQGKKKRRRPLQPPPGTKVDLSPLPVPLKSLHSLHFLANPTPLEEQPATPNPGLGFLDVQLLHHRLVRYSRTRDLAYLAWILHRYAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK13</accession>
    <name>W3VK13_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK13"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="72"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="524" mass="57508" checksum="B69BCA85DDFB2CBB" modified="2014-03-19" version="1">MTSTTSPSAVVDVMQRDIERASSEDEKNAEFKQGSGDVAQLYASGTPKSEPSLIVYDAATEKRLVRKVDLMIVPTVAMLYLMCFIDRANVGNARIAGLEKDLGMNPKSYDFNILLTAFYAAYAAFEIPSTTLTKILGPGRWIPMMAFLFGLLSLANAFVTNFASAVAVRFLLGVAEAGMLPSIAYYLSRWYKKDELVFRLGLYLVTAPSAGAFGGLLASAILKIPHIGSVRSWEMIFLVEGLITIVVAIVGYFTLTDSIHTARWLTEDEKRFLQARLKSELVGQKQLVDKTHKKLIWKGITNTTSLACAMMFLFDNISVQGTAVFLPSVVRGIFPAPKYDVIDQQLLTVPPNVAGAIATLAFAYASAKFRIRSVFVVSGTVLMIIGYSMFLGSKNLYVRYAASFFATSGAFTMGALLPAYAAVNTNNDSERTGAIAVTVFFGNIGGLISTWSYLSKYAPNYVPGNALNLAGAIVMIIIAVCLVSWQRWENKQREAGKRDWKLEGLSEDEIQMLGSDHPHFRLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKA8</accession>
    <name>W3VKA8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKA8"/>
    <dbReference type="HOGENOM" id="CLU_307195_0_0_1"/>
    <dbReference type="OrthoDB" id="2554070at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="963" mass="103518" checksum="8C5FDE596209E239" modified="2014-03-19" version="1">MASVDAYPRSASLDLLRSPTVSPLPARASFESVSTLRGHRISSPIFLNSSVGVHPQQQDEEPKTPRHETSDHLRSKFSMSPLQPSKRNKARVSQDPPYVARLEAKTTIGHWSHSLGAAARRLQNTLPRRGDAVATVKINSDSNEVTPDKKALKGAASFASIRRLITPSRRTRKVSAAPRLAVPRSAIVEVEKGPEPGPAAAHDDAGWIDAEGSAESGALSRSSERAQLHVGTSPPDSICATRPGNRCSKSSSVSDQNGRSASADVLARCATNSSDQNGATVNARTDAESTHSITHEIPEEDVSLLGGGITERDQTSKTWSNPPPPAPSKLKTLQLLARRPFHAFGRKMREMDVSWWPRSSQDEASFQPPTSQCTAPAFALRRSEDLLSKASPRVCPYANPSRSLDQDRIELPSKVVPILSTGTAVYKRRPNIPEAFVRQVPASAAQPRPLERTTVSAPLLAPRISNNRHPWMKQLHLSNNLAAQADANTEPSLMQDQTRSVAKGTKDAKGAVPKLSLTAAEDPVHMPMYGSSRVVDIEDSACRRPPASLLGQSLPIPPRGGRRRASTISSQSSSVSSPSGKVIVSRRSYGQRSCSPGSRERAGSIRSVGTSILFGETPPGTPGLRRMLSPQISSGSPSRGVYVRSPSKVVLVPKYSPARHRQAERELHRKPSSSFSANSEQEEEQEWVDEAPANAKRLDLVAIRSKIEAALPAARPGFLEMSEATDTLSYLVKTFNGSSGSLISNSSPFKTGGLADPTSPRDLYGIAEADEIHLPRRSASYLGGRTRVRLTSKASLVSTEANSSFEDSEELQKLLDSIMATDLGNSCDTSGSRGDMALLSPFGSPADRLEPCGDASCASESRCRATPRSSPMPPPPKFLLNDRPISPPDSTNMSECMHTSASDDPCTAPQPPPASQQFEIAPALLCRTASWSSATSQTKISRVPVATLNSHHAQRQSPFTSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKD7</accession>
    <name>W3VKD7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKD7"/>
    <dbReference type="HOGENOM" id="CLU_125054_0_3_1"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="102" mass="11814" checksum="0AA3241E4BB13B1E" modified="2014-03-19" version="1">MLPSLRLLSAQAGRVFKLTLYTGTDCQLCDVMRNEIATAAQHVPLTLATYNIRDDSLDNVHYWRRKYQYDIPVLHLDGQEIFRHRLTAAELVAKLQSRRAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKF8</accession>
    <name>W3VKF8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252017_0_0_1"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cDENN" evidence="3">
        <location>
            <begin position="367"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="934"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="687"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="880"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1402" mass="152128" checksum="2CA747E8DAC6D0FD" modified="2014-03-19" version="1">MPAQTNGAGPSRSASRSGGLSGKFSLSNLSIKSADARNGARTPKSAHRPFLSNPGPRSTNGRTSNLSTSSVAKSTDGNNIAQLYAVFGLPKDPAVWTLAEEDSTNGVHHIESAVGRFWRPEVLGCSICPPINPVEEVPKTPLSPQSPSDKKDAKSSAWGSNNDKKNGSNPKFIEMADGRGGIERAETARVLSKALKLSFTREIEISTGPIHFPPSSTSHTFSFSVPTVKSSASGGAARPSTDVRNAGAPFSVSAANVHNTRSFSAVGEGFGLEGVSSRLPAGAGGSGDDTPGTATFYGSVLTVWSAADDKRAKAIRKELGRLAKARATARTATTNKIVNNDGEDIEDDAELTSALGHSILPDNNAFFMPYAICIVSRYPIYNLLGDWNKAAWFKYSRNIEMHNKLMAAILRHPAPRIGETFRLPSPDEDLAFVCTFPGALDWGRGLLGIDFSMWPLFKALSIDNVLTICEIALAPAGRILFMSRHPALMGMAVETVKYLVELCGWKGIAHQNCHARDVRIYLEDPGSWLIAINTELRSIIKPPKEVCIVDLDINFVNCPRPPLKAPSKGAARDRKRRKLIAALGFSSADYTIPREYVEAFPSGRFRPLSKVESTSRDVAYERLETPQWWDQGALVGAFDHVLHEGTKPSFLKKMLRMRTDKQAVASETEQAAVLALRKRASTFVDARDGLENKIGRLNKRLAFLMSEGEMWRQQFDKIQQLVDRLTREAGDLRAKLDKERRESRRLSSTLQQRDLEYVQAQIQLKETEQAREKAQGELLRMRTAMENLESEREAMMDEIRNVLSTSGDDFGMASLGNLQSMTQNYTRLDGAGSPAASDASHNTEMHIMRSRALAEQRISMGQPRTPSRLNKGSVAPSQDAHANGASGAPNASASNHFPDEQMNNEIQKRTTAVTDQIAKIQQQLESTLTQLEGRRSVTLERSRRLSSSSSVGSHRFDAASSVGHHNAVASSVGHGDAVYDYRPSEEVETMNGERSAVPRRQRTASSTNHASAQRSNQLARPAPVLTPKSPARGQRESLVSSTAPHTDNSSLEANGHATSSPPSEPQPAEATKDAALVATAATAGAAAAIVGAAASPAALGNGKQEVAPVELEAVGDRSKELPDVPADSSSVDVDPSRPDESDAADEDDGDALNMFDEPDDFRPKTPPATVTYYEFPGTSSKVTLNLVGSHPLWGHLAWNASFIMADFLCAHALTLTKGKRVLELGAAAGLPSIVCNWASASHVVATDYPDKALIDNLTRNIVENCQDEASPLRGAGETFVEGYIWGRDATPLLERAGGKFDLILMSDLVFNHQAHPALLDTCDACLSDAVAESGVATPCVLVFFTHHRPHLAYKDMQFFDMAEVKGWKFEKLGEWFKEPMFPQDPGDEVVRSTIHGFRLWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKG0</accession>
    <name>W3VKG0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THO complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKG0"/>
    <dbReference type="HOGENOM" id="CLU_746381_0_0_1"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="40983" checksum="6900A98A6148FC0C" modified="2014-03-19" version="1">MASSAASGSRASIQPLSSEQQEAVIKSRMQVDERTLRRVVKKLTLLLSSTDAEVVAASRLSFQSELEAFRLQLARLSSIARNTSEVEISSYTHELSEIESEQEATQARIHALKRRLDEVRRERKNKLEYDVVAGEIVKLPTRAELDESLARLREQLDQVRAEREKYTHMSHDAAQRMRGVIDGLEALRNDVGYEVGERERREVERADGDADGEAGDAGAAGDDGSELGRGKRAGKDRDEPEEGEDDEREEGEQSAAVSRSGSSTPRRTLGDDEARPAAGSAATLNASAPAFRPGGTGTGRKRDSAAVAGSDEEGELDDGSSAGATAAAAASNSNTPRKRQRTEEGEVGTAGDSEEEEGSIRPAAAAAEPSRPARAGTKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKM4</accession>
    <name>W3VKM4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Effector family protein Eff1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKM4"/>
    <dbReference type="HOGENOM" id="CLU_634796_0_0_1"/>
    <dbReference type="OrthoDB" id="2556674at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833275" description="Effector family protein Eff1" evidence="2">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48066" checksum="6045B156C2978C60" modified="2014-03-19" version="1">MELSWRLRCQLGALLTILFISAIPASPTGGGGWDIGEIVGHGARDGGLWGQNPAAWLNRDLAASSSGSHGGRSEDPGYHASHNSRMQSTSFESPRQSPIWSEPRLDATEQRSPILHGQGAAPVQPAAAPIVTSESETGSTSLLNAPASSQPLVTKPHRIPSNPRAPLAYAWFGEDVGRSMIENGLYKLDRANTIFRDDVGEWEKWLANMRRATGRPSLRISPVDVSDSAKDQVFVAEDLDTVDHPPLTESERVLRWSGRLLLKKVPPGKVEHNLEKAKARDRVYVYLNSRRNMDYINREYFLGHARPLPIHIDGLTRNSLNKIYAFRNTHVLFPPRTQHGLPLLVVRHIGSEYTLEHIHSITGIKQKMHLMSLWSPLLFDGQRYTTFLYGVVGFDSRHAPEVLAHLDTMTKASDPSSYASLYVLEEAAHMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKR0</accession>
    <name>W3VKR0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PaG_03660</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_2_0_1"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Carrier" evidence="21">
        <location>
            <begin position="2393"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="22">
        <location>
            <begin position="3357"/>
            <end position="3795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2833"/>
            <end position="2865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="3578"/>
            <end position="3602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="2833"/>
            <end position="2843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="3578"/>
            <end position="3593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ETS62100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="4026" mass="438182" checksum="EE2F67FB5861C2A1" modified="2014-03-19" version="1">MSAVKNNAPSDDSYVEVSTASSQTSSNGNANGTLLRALTIASTSGVEVQIPVPSQPFDAWIVADVLREEFQRSLAAAPEVTDVLEVQEEQEDAGTADKAAGEAKVSLAAKFLGFLASRATVKSSSHELNLLHSTWIHFHDHFVAQRGSVHDLVAALDTDLRISVLRSYFEAFAQLESAGKAKPALITPKLFSLSAQNKAEVHAVFGGQGNNERSVADAQVSAACRSVWHGQSCIRLWPNFLHPKPRSPISKVLGLCPFLTRWSSAKADSIPKKKEKESERSAIASARDSDRHDPASGTDSRPENALARAFKLTSDDVRLENQRLTFPFYLLLIFSATQAYFKELQTLFDAYRPLVQPLLESTQPIFDQLVQDAVKQGFGSYYTHGIDVLGWLTGAVPEPAVAYLASVPLSLPLIGLTQITQFLVSIRASGLTPAEFRAQIKSATGHSQGIISAVVLSASGSLESFYANVAKALELLFHIGKRGQEFFPTLAIDPALVKDTVDGGEGEPAPMLSVSGLEQTVLEKHIQKTNSHLPESQAVSISLFNGPRSFIVTGYPKALVGLVGSLRAIRADTGADQGKVPFSKRKAVFRMNFLPVGVPYHSSYLTGATDKMLQEDYAGRTTVWDASELKVAVKNTEDGSDLASYRSEDILKSIADQIFVKHIYWAKASDLPKTATHLIDFGTGGLSGIGGLSARILEGRGVRIVIPSGTHARSTELYSATKVDFEERWEDVWSPRLVRTKNGIKIDTPFSRTTGRGVLMVGGMTPTTVSANINAAVLNAGYVIELAGGGLHSEAGLRKRVNEILAQLEPGNGLELNGLFIDQRRFGWQYPLWGQMRREGFPCKGFTVAAGIPSTEKAKEIIDGLKAAGIEYVGFKPGTADGLRAVAAIAAANPDFKIICQWTGGRAGGHHSTEDFHQPILQTYASLRKQKNLILVGGSGFGDAEGVWPYLTGEWSVKLGYAPMPFSAFLFASWMLVAKEAATADAVKQLLVDTPGCGDDKWQDTYGKGAGGTITCNSELGESISYVHNRAAALWRQLDDQLFSLPREKQRVWLSEKKSWLIERLNKDFQKPWFPAKLDGSALMNVADMTYEEVTRRMLQLLFVSHQSRWIDPSLKKLFGDWCRRVEERFAGIETAGKKESLLQSYSVLDKQPASFVDTFFAEYTGAKEIRLAAEDVGYFLTICQRRGQKPVPFIPELGDNFQTLFKKDSLWQSEDLDAVVGRDAQKVIILQGSVAVRHCTKANVPAGEMLGEIERELVARVLARYYDNDESKVPYADYVSSDPLAIEEAEFAARSGVDVSVADNVKTFKVGSSVPDTKEWLEVLATSRTSWLRALLRNVSVVQGKNYADNPMLRMLAPRKHQTAKIAYAANGEPISLTLFGAARSYGRHDDSFKAIEITKSPESAQIQVTLFEERLGEAVPLHFFFTYRPDQPFASIHEVMDGRNDRIKQFYWQLWFHADMPAAAQLASAKEFKSPVKSLDESAIRSFCRIVENRGEVFTKGQAPMDFAIVAGWEAIMQALMASCDADLLSLVHLSNSFKVIDDARPLRAGDVCTATAHASSIRISDTGKSVSVTGTVLRQDANATPVPVISVVSSFFFRGRFTDFNTCFETSQNEFVLDIKTKADATVLLSKEWFDWVAPQPLIPGTSLHFKIENLLRYKDSSSYSDVDVTGGAYVRDFKDDLIKVGEIEYTADAASYGNPVIEYIKRHGGVSTGGVAPLESGYTLGSSDVPSTFVAPATNEPYSNVSGDFNPIHINPYFSSFASLPGTITHGLFSSAASRKFVEVVAAEGYPDRCLSFEANFVGMVLPGDELNVKLRHIAMRDGNKVVKVETFNQNGDKVIDGQAEIKQPATVYVFTGQGSQEQGMGMDLYNSSPTAKALWDEADGHLRSTMGFSILEIINQNPLTKTIHFGGVRGHTIRERYMSMTYESTDADGNTVTLPLFPEITSSSQSYTFQSPKGLLFATQFAQIALVLVELSAFRDMTQRGLITPDAAFAGHSLGEYASLAAVASVLEVKSLCDVVFYRGLSMQNCVQRDPVTGASNYAMMACNPLRIVGDGNPAFAGQALAEIVDSISQESGRLLQIVNHNVAGQQYVAAGDLVALTTLGNVLNFIKVQKIDLKKLNEIMPIEEVREKLAEIVREVLSAALEEEKKGRIELKRGFATIPLPGIDVPFHSRYLTGGVAPFRSYLSKRINVDAIRPQLLVGRYIPNLVAAPFELSKSYAELIFAQTDSPRLDKVLKNWEKDEWESPERVQRLTATLVVELLAYQFASPVRWIETQDIMFTDYNFERLVEFGPSPTLVGMAKRTQALKYSAVDLAQGRKRVMLCSSKDKEALYYSFADDESEAEAAAATEAPAAAAAPAAAPAPAAAAAAPAPAAAGGAAAADVPDEPLKAVDTVRAILAQKLKKSISEVPLSKSIKDSVGGKSVLSNELVSDLLAEFGNLPERGEELPLEELGGALQAGYSGSLGKTTSSLITRTVGGKLPGGFNLSAVKSHLQKAWGLGSGRIDGVLLVAITMEPAKRLGSEAEAKAWLDSVAQTYAGLAGISLSQAGAGGGGGGSGGVAISSEELDKLKAQQDDHVRRQIQVLERYLNMDGRAGGRLAESTKAELEAAQAQLDAIAAEHGDMYTNGIMPKFTEKKVRHFSSYWNWARQDAMTLLYDIIYGRLTTVDREITARCITLMNRADPSLLRYMQFHIDQIDAEKGPTYALAKEYGQQLIENCREACAEDAVYKEVHAPTAPHTEIDSRGNIAYSEVKRVGVRKLEAYVKEMAAGSRLLGAGSQVNLDKAQENVAKLWTLIRNEPSVSKLSKATIKSLYSEVVRSLGPARQARAPARQATRSRRLSSNTQRPQVSDAPAAEDRTPFLHVKRKVAGQWQLSRKLTSVYLDILGEMATQGVSFKGRNALLTGVGKASIGVEVVKGLLAGGARVVITTSSYSRSVVEYYQRIYQEVGSRGSTLTVVPFNQASKQDVDNLVKYIYGSLDLDLDFVVPFAAISENGREIDGIDDKSELAHRLMLTNLIRLLGAIKTEKASRNFDTRPTQVLLPLSPNHGTFGGDGLYGESKLGLETLLNRWESESWGQYLCITGAIIGWCRGTGLMSSSNTVAEEIEKLGCRTFSTTEMAFNLLGLLAPTVSAVSQVEALLVDLNGGMDKIVDLAEQTGKFRAAIQEASSTKRALVADNSADFKVIKGSAAEALHKKVHINPRSNFTFRFPEVGTLDFNREIAKSYSEMDLEKVVVITGFAEVGPWGSSRTRWEMEAFGHLTNEGVIELAWIMGLIKHHDGQLKSGATYVGWVDTKSGEPVDDKDIRANYEEHIVKHAGIRLIEPELFRNYDPNRKGFQQEIELNHDLEPLEVSAEEAAKYKLEHGDKVDAWQDASTGGWFVVLKKGARIFVPKAVAFDRLVAGQIPTGWTGQRYGIPDDIVAQVDRTTLWALVCASEALVNSGISDPYELYKHIHPSKVGSCIGSGMGGMTSLSKMFRDRRNDNDVQKDILQETFINSVAGWVNLLVMSSAGPIKTVVGACATALQSIDVAVETILSGKAELMLAGGFDDLSEEGSFEFANMKATSNGKEELAAGREPSEHSRPFSTSRSGFMESQGCGVQVLTTAANAIKLGMPIQGIVAYSNTHTDGAGRSLPAPGHGVISSADGMQRALARFNLTADDIGVISAHMTATKANDKNESHVYQELFTRMGRTPGHAVPVMAQKWLCGHAKGGAAAWALNGVMQSLHTSIVCGNRNADDISPELQKFDMLLYNSTSIHRTPHHVNAAAVSSFGFGQVGGIILVLHAAHILGRLSPKVFEGYVERRKARQHHTYTRMHSALTKEDLVRIKDNRPWPAEMEDQVLMNLNARAVEMGDSYGFKAPLPPMPALATTEDVIVPAKSAEVAAQQESLQKMMGHVAGVGIDCEKISTFPSDNDSFVSRNFTDVEIEYCRAQPDAKASFCGRFCAAEAVFKSLGVRSQGSGASLKDVEIVPTPEGPQVKLYGEALKAAHGSRFLVSISHGDDTAMAIVHRLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKR1</accession>
    <name>W3VKR1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_04357</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKR1"/>
    <dbReference type="HOGENOM" id="CLU_108081_1_1_1"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS61336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="125" mass="14858" checksum="F51E53FC341149BB" modified="2014-03-19" version="1">MFASLILRNSSTSTGASAFSHAHKAYVKSLYRRYLKNELDWCIRRDVWRDRAIEIRVAFERNRNIRNPRELANLFEKAERELKTRQHPDPHRPAMFEDGTKWERNLPPPMFTEAEKKAALDAQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKT3</accession>
    <name>W3VKT3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SOK1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKT3"/>
    <dbReference type="HOGENOM" id="CLU_264197_0_0_1"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1268" mass="134959" checksum="D90FF3C366F3A8BB" modified="2014-03-19" version="1">MDASADDPQRFRIRRSPSIGTSAAAVGPASTRSGKRKLSTAAFASSPSMAPHPPSSPITSEHPTDELKLKQGIQTASQATSTSRSTVDASDATSSNAESSSAAAAHPNASASHAQFHEWQDQRRCHSVLADYDYLHPTEDRRDPRSSNARLVMPVSQQSQTVACSSAHDRPASEMESHTSLQPPPIALQHDDDSANDGTCDTAPSHTGLGPSASLPLSPECNVSPSPSFAAYGYPDTPPHVSQRLSSSLSQDRPGTASASTSASASSHRLSSIAESSNERTGPTDACSTNHTASETSRPWTRATSLRFDQAEQRERSPVGEATHNASQSPDPFRLQPVPPSKRRKLDDSLAGATHAGLGSPARIDDARRSSDAGIASDSAQVRNGVDKKAGEALFEDKPGFLNHTQRAALVPSAQPTAPASLSVARTSSAHAARLDQSTDARNAAHAPATSKHNAHAEAIQRKQHAWPSRKYSRLTRAQSVPNLRAKATLDVSAPSHHRLILPSHLAGYVSSQSRQSRSGQNGSKGSTMRLSKGLPLNLAHYSVGTSSSRSRSTFTPTLHPPITRHTLRELDLLEILKNPQLRHDVVFDPNVQFRPNFDGERGRRKREAGERYWAAVVREIETGCTCTAFSHGQLLPCTCRAKGRSLPAGAACLRDAAAGPDGKRDSKGRPPLPNSRIPSRIPLLVQELRTICLSILPSNYPADSAGVVAEEASATSTDDSKVGDEASSGRDGMASGKAPAPASSGVPSLATTHHQLIAHTLDPHLIAQELQHGVLDVPALITFMGSILKLHCAPMRDEAIEKMVEVVCIDHDIGKGLRLCFEILELMKLDIANHQLRSARPFLVETAVDFEIRWFKEQIEQGKMSLDKTTAWMRQALSEASDDSGLPRSHVMVTAFSRGMLQLIFDVPGTLPVLSQVATPLGSPSSSSLNNTFATLYPETFQFDAYRMMTFHNDVSDLTIVYMLLLLFRQLCGTPLDDGAPLPACVGSLVQRQLKSIKGEIWCLLNDANLCLSGSGGVSAAPAAASSASGASRRAAGVEGKPFLGSAGGFAKLDHPRWRRAMQNVLLQIAARAAAVQTAARTGTSDPSAVQTAAPSAKTQQLLNSWMETNLRSGSALHKICQSRLRDVVLGMLTDKVRSSLPIVTALPVAASKGGEPSASQQKRANSSEDGDADDGASVSKRHRTDAGSDATSSDQVANTAGVAAGTSTPWDAAMSRAGLEPFAAEIRLLSDRVAKVATFHLRVFRHLYEGFEAGRAQAAQQPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL53</accession>
    <name>W3VL53_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL53"/>
    <dbReference type="HOGENOM" id="CLU_020990_0_0_1"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="83012" checksum="AEEF2A7150706FA2" modified="2014-03-19" version="1">MDRPRRSTRQSTSALQSPAPTPAPSTSAAAASSAIVPPVAMANGNATPSRFEAGYSSNTTFQQPMTPQPAPGFAHPSSQNFAHQRPHMAMDAPAPHPISQLSLQSLPNVHVMGRGAAPIAPGTSVAPPRPFGTAASAPTVPQAMYSTFPSRIKAGTTNLLQSMPQSEWYDPSGRPLDPLATPTHEYAGGSTPYRAARASGRRRAAAGYIRYAEAGSSDDDFEEDAAGTEDDAARSGSKRRLEDEDDESSRAYLGLPPPASRVVAKRMFHRTNHVYHNDDDLARQAGRNEILVPIKIDLEAEQYRIKDSFTWNMNERLISPHHFARLLLEDLDIPVEPYATQITNMINQQIDDATGVADIEMEPAAGGVWASARLHDQEGQIALPVAERAQYDAKEELVKEGRSWDWGLERRDEEQRAWRKRMAERLDAGQGLGDSEDDLRVIVDYEVQILRHMLRDRLEWDLCSPLTPESFARKLCDDLGLSGEAAALIANSVREQLIHHKRAALELGLVGSGRVLKEKEAEIEQAWAELHAEKVDKQRKRLERATSASEAQSQVASANATGGANTREPSVQPSADEQPKAGVEGQESIATARGSVDADAVTGEVEARTTPAPGADDDDDEDVETLHLTATATAAPTREGTSTPAIQPASTPAPATRSSARLSNMLDGVASGSGAATPSGPAVEPVVSASQRLHNASYTVREILSRGPRPLEGIWRDWHESREFGPLLERLNDDDLEKLEEANIRASRRNRREAARAFGGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLE3</accession>
    <name>W3VLE3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF431-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLE3"/>
    <dbReference type="HOGENOM" id="CLU_080487_0_0_1"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29689" checksum="BCDF3D3E10E087A5" modified="2014-03-19" version="1">MSSASSAVLPAGKRPEYVIEHMEEDDPDAPAVFPHWALLEYRHMLELVGPGSTVHFTSLSHASLESLRQSLSTPSNKPQAQFELHTASITTMMSQRGIGLDRVCLLDPKSPFAVSITDAGKHTSDTKPAQAGGPFQLFLFGGILGDDPPRDRTSSLRQLGFPSRHLGGVQMTTDTALGVTKRCVEDGFLLALDDTTQQEQQWGDAAKASAKLEWVNHPELHFGHGESVEMPFRYMVDEERPALADGSRQPLMPHGMRQLIQNDLGRSFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLF1</accession>
    <name>W3VLF1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alternative cyclin pcl12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLF1"/>
    <dbReference type="HOGENOM" id="CLU_050728_1_0_1"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="97"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="360" mass="38603" checksum="F71E9C826618C3E9" modified="2014-03-19" version="1">MAATVAPAYNASHGHQSAVDVSAASATAATTKASSSSSSSSRPSQRSEPQDRFYGYRETSELCERFILYLFACPLDSTSASASLASSNGTPAPRLSEFIAYALYRTRLPEVVTFQALFLLLRLKIRFPAARGSSGHRLFISALMIASKSSCDDTYSNKSWAIVGQGLFSLREINQMERELFGYLGYKVNVSPEELEVFTYELEQDCDGGRIDLVVRKILQLMSRRNSIDDASIGMARERSESVSSAKSSAPPTPALESSGFSSPSLDSHAGPQRVSSGRHSRQSSVSHSFGQRASISGYAPATMAMSSSTGHLASATSTAAAAAMPAATPMVKSASHRQERSATAPSFIHPFINHARERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLR5</accession>
    <name>W3VLR5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetiocal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLR5"/>
    <dbReference type="HOGENOM" id="CLU_058254_0_0_1"/>
    <dbReference type="OrthoDB" id="5586934at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="269" mass="29462" checksum="0638B7CCB8725753" modified="2014-03-19" version="1">MAWNDDLLLKVANIASYALFTSGNVYAQLQGTVVSETYLTPSRWIFGVWPFIHFLFLGMIIYQFTEAGSAHVVRGIGWRFPLLCILNAAYSGLSSAQMNAHHDRVYAIVAFVVMLLIAATVSHCYRSLKVHHTASNLADTAVVHLPFSLYHGFVVVLLFVSGFEAFGVNANTHKAGIITKIVVFLSLLFLESTAAGYVWYSEGDVAGAAVISLSLLAIFQHQTSSKFIHWSALAFFIISLVAVLRAVIAIFTNRNTTAISDEERAPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM09</accession>
    <name>W3VM09_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin interacting protein 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005287_0_0_1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="3">
        <location>
            <begin position="763"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="923"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1282"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1292" mass="138398" checksum="3B631AC6FEB70229" modified="2014-03-19" version="1">MFSNLISSRKGSGDRTNASASANHRLSGTTQPVTAERIRHPQHVYAHEGSSSPSYENSPHGSSYMSRKDSAGSTSAASAWNSPGGAPTYSRSPAQLPEEMRAREKQRQAERERERERRERQSSQSSVNTPAPAPAVAATLAHDSPAKYSSSHMESSVTRLLVATKMLLESLTKWSVGQRSEEDVSDIYVRLGNDFNSAKLAFGSYGIDMSDLSSVPDDLRDCLERCLSEEASPAVLEVHLPRIREIIINLLQGLKMKQAEYKQFLVQQRAVKEARRSSLLGDVQATSTPPPARQPQPQPQTSSRVLGPRASRQGVSEGGFAASSDSHATATSSATSSQRPESLQRASSAGAALLSDRTSQPAAGPDDAADASSATAAARSNSSIVRPPSRVSRTASERTAEKRSSEQHSPAPPQPATLASSDASETDSGQVTPRMPSVERHTLVDDGAVAPPVAAESDDEQENLTDEPTAPVSMTPQRLSTRSPRHTPKSSVDAEDYTDHDPSLRALKNRDALERRASKRFSAYTFNKMGIGQSYSQGLGMNMFPPSSTGGNGSPLAERKPSERRGSGARRVVRPPLPESSPALEAAGLSSPSTFTRTADYFGSASASGSGNGAGAGGARAIPRSRSAATVDSKFESIEEVKTPTSSTFSRDGRSPSPEPRAKDAEPLSSTATARASGQSRDLLSPTPPGGRVTSHAASSTESLPFVDAQPPASDAGDVAEAHPTTAKPGSLDSKALGASINAVPSTPRSRTIQASPDALNVFLQLGRQTRKAVIELDSTNPITRGISVARLRMLFIDRFAYSPGMDDFPTIYLKDPASGVTYELEDLADVQEGSLLTLNIEPLDQVKQHLDLSLGTISREIRELKTALAERERDARRMSHGFVGNDTLLAVTPAHATPTKISDSQFQAAGQRVAQLKRANTRAAGAQHEESGAPLVQSPSVASPTSSAMAGSRIAHELKVQFDELQNLRREFAITRQLQTDFEGDVKSILTTVREQAGAVRAIASTKVAAERNFIVAGKSRLDTQSQDLLTLIEDLQDTVDDLRVDVIQRGVKPKPVLVKQIVDDVERATNGLVELEEYVQTVKPSWKKTWESELQNIVDEQEFLNHEEGLLSDLRDDLGALREVFSNIQQVVKLRGGSGKGGKYIPPLPEDGHEGLSTVMMEVKSQAVNHEKRLRALQAVERQRQKDMLASKANDEFSEELAGFVDKKVLRKTGGVLEAERVRQKRDHATWKAMFGGGGPGGIPMAPSASGGAEAKPKKLILGAKKAADAAKQPPSASKHTASTSEHAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM47</accession>
    <name>W3VM47_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM47"/>
    <dbReference type="HOGENOM" id="CLU_348545_0_0_1"/>
    <dbReference type="OrthoDB" id="2523383at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="448"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="809" mass="88442" checksum="2AA62772224B0B4E" modified="2014-03-19" version="1">MTTIPSRLAQTTYISRSIEEARRRSTALYRNFYRSAPEICALYALDVPPSTLRAKFRTQFEKNKAIKDVAVLDVMLLKAQQEYQETMNGWKQVPHIMKWFADEEAPARPEGFLEKFYASRDEGRGPVALKYRHQAHHADMKDHGASMLGPWRGGARLASARSRVFVDATQMVLPAARKLSPPPNAKQPHTALREWSPNAIRLLSPTALRKFGPSLDREARTESDAGLVWESWLVGCALGSERIGATDEEVRACTPVTPSSPLHKMRSLLCNVTLLGPSGPTGRLGEAKPRAMSQATHAILLKPTRIASLLSAAHLDQRCSMQPTGFRPRRPPLTPTPVTPLINDSAAPPLKLAHWSRASLSSTMIMSPSSKPNPLTTFLSESPAGRRSANGAIPICLPSKPALVASERVSMLQSPPSAAKDAIKQLGCLASVSSNTLPVQRALQPVDVNLSKSSRHRALPTKRPSSPKKVRSTSNAGVGARSKSPKLATPTPSSAPLIFRGDRISVKIPQKLPAPRLTPHSSPYEDLVAHLARHNLFIESQQVEQYSIAPDFLLQQYLELAHLGKCSLYHQTRNFLFANRDTITAHVVPGQTLPSSVPLDVTPLVTELQVPPTHLLAVHSDREAATLYAVHGVVLALQCVSIPFLPASKDSQDGARVVKHMPVLALRMPAPQHFETTLRWLYSQSATSLLQELLPLKHILAVLAKRRPCGSAVEGKDVEASAAALSTADLVQAMSSLPMRTFLEHLQTIQAVWKNGVALGIVAWNFWAQLDNAWNLLVVAMVASKRKNARKSLAAASELTAQLESTRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM58</accession>
    <name>W3VM58_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM58"/>
    <dbReference type="HOGENOM" id="CLU_1107508_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="251" mass="27511" checksum="C3321A4C707E50D5" modified="2014-03-19" version="1">MMRPDDDDGNDDGAPDNDYATNDDGASDDDHASHDGVDLSFLFKSISSLILEERFPTQHARVDASPEGTPISDDDEMTFETPRGRSIEAAHVGTAHAPAPVPAPSHGAVRVDSQGYYLPSQTEYSSKYLLGPEDFKEVGGTANEPATIGLVVLILKNDWNHKVGKAKFKIVHIDSGDGKKSARDGKKTHLYVDNDSDLYRIKFQGSTWDRGAIARLHDVSFELKSGRPIQDGSQILDSPCSRCVRRDIWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMG3</accession>
    <name>W3VMG3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal L1 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the universal ribosomal protein uL1 family. Highly divergent.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMG3"/>
    <dbReference type="HOGENOM" id="CLU_026457_4_1_1"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000004">
        <property type="entry name" value="Ribosomal L1 domain-containing 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="351" mass="37587" checksum="16952F19108F561D" modified="2014-03-19" version="1">MPAKTKTTAAVATKPVVASPSSQQIGVAASNIDQAQVLKAFSALAAHIARRNGASSSDLPLDGPQGDVRDASNAVYLQMTLNTLHPTSHVKPVRINLPHGLHTPGSTSVCLLVKDPQREYKDLLVQHNIRCIDRVVGVTKLKGKFKPFDARRALVQEHDMFLADARIVPTLPNLCGKVFFDAKKNPITVNIQKNGDALKAELESAIKATTYTQNKGSCTSIKLGFLASHTPEQLTDNLMAALPAVLSRVKGGWENVHNLDVKTGNSAALPIWNAKLGLKTNVSPSKPLAPESTPDKKQSKMDKVETPNKSVSPRKTRAAAAKAVQAADKPQPKSTTKKSASSTTRAARKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMR2</accession>
    <name>W3VMR2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dibenzothiophene desulfurization enzyme C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMR2"/>
    <dbReference type="HOGENOM" id="CLU_018204_10_1_1"/>
    <dbReference type="OrthoDB" id="5356974at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000020">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase YdbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000025">
        <property type="entry name" value="Related to Dibenzothiophene desulfurization enzyme C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="4">
        <location>
            <begin position="62"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="275"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="47937" checksum="5832398104834D66" modified="2014-03-19" version="1">MAPTATVASGDTNAAPAAVKGASRIQPDPEVVQYPKFNKDPVTPEEVFARAAQVSELLHEDEAIRDRGNVVPYRQVQLLKDAGLVTILGPKSAGGAGLTWKEAYEVIRIIARGDGSLGQLIGYHYLWSWAGALVGTDEQRTRFEEWITKNKYFVGGAVNPRDADLKVQQDPNDADKLVFNGKKTFSTGSKISDVTILEGSLPEGGHVFAAVLSKQAGIVYGDEWVDTLGMRGTQSGGISITNVVVSWSDALGFVNKQFQPIGAYNTLNLPQIQLVFTSFYLGIAEGALARAAAYTKANTRGWPYQPNPVARGTDEAYIQIGYGDLQAKLWATASFIESVFAEASAILHTAPRQQVTEEQRAKFAVRVAAAKINAVDVGLAVTSQIYELTGARAVAGKYGFDVAFRDLRTHSLHDPIAHKRAEVGRFTLHGPGKDGWPTPTWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMT3</accession>
    <name>W3VMT3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMT3"/>
    <dbReference type="HOGENOM" id="CLU_004400_0_0_1"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="43"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1131"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1184" mass="128388" checksum="9A9962407C7678EF" modified="2014-03-19" version="1">MTAPQEPVPPYALAPLLIPTLGSDEHAESLHHESPDAIQHHAQRSIRCSESDGTHLYIGTSDGQIHSFNIRYRKSATAPGSSQQCTYSLKSSRSVSNHTKPVEKIVLLRPFRAAAVLCEGVVNFFSTPDWTPIRSLPSTRAVSTIVLDDEEAQSDTGTDAAGMISVCLVRRKNIILAKIGSDGRSDLLWSTIKDVPLPGGAIFARRYADTLCIANATEYSLVNLSSGSITQLHLPISQTGESPSAQVRPSIVTVPVPPSSQRQGSVSPEVGRASSAAASPSANCEFLVTSHSGSITLGVFVKPSGEPAPKLLEWPSHPRSVAFDGKHLVSLLRNDTLELHRIGSDSTHRVQTIQLPPGLDPRFLQPVSHPAAAHPSASNPSVSTTCDLDIVKVSLAHLDSSDAALLSRAQEYPHALLPSRCQILLCGRNSTSAVQQDSLLGWTAQQLRCGRIRNLRHNLASYRENADEDATNSTALQSSLEASAAHARLGIELLHRADFAAAADSLRHAHLDPRLILGCFPSLLPEGQALGEAILPALLLPDLEKLKRKDGDGIQSIQDMIVANLTLNYSPPLDVNKDRALSELKQTLLHRSDAMLRRLLEDWRAAAANAAHPWAGAYMDEHMLANVHNRVDSAYLHLLAQGRGTDNPDAASIKREMAAFLDSNHACEPTVVEKLLKDKGFLLLLARHYESVGNIEGALNILAGLVDGKQGDALEQSIDTSATVSKIADLLSGQQDASLVSEYGRWLVRKDPEAGIRILTAQTAASDSAATSKTPSRSKAQELDAIRLQKATIDELRQIDADAATKYLEVVALSTSKVQDEQMHRELAAALIRRVAKHLEDGEYRTKMESIEHEYAHGSYAESFFAHLALACSGSSMDVDRLKLSMLLQGSTMLDHGAVLSMIEPLPTLAYERAIVLGKLGRDADALSLLAITLRDANSAEAYCSQDGEVLSPMLAASIAEDHEELRPFAAMLSRTHAQRIKTHAKQEQQAGRTGAAQRKETLLKELLSVYMANGAHEKFRIATAHLLNTQALHLDSQQVLELVPADWSIQTLETFLTQSLRRQLHRRREVAMLRSIAKCRNLDLAEDLWARQRAMGGVVQDTDLGGAVDSAGSYDAVQQSSLAEGQVKAHIDDRDDGLGEKHRSSGLDTSDRAKVEIVHADYRIPTSAVVHAEREDGTDSDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMU6</accession>
    <name>W3VMU6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02651</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMU6"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_5_1"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="33"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="505" mass="52991" checksum="CDF9B2F42EC94541" modified="2014-03-19" version="1">MSPNTEAGTPSRPAFPASSASSRSAVTLRFRLALLWILFSAANYGYGISELNALQPILTCHPRDPSSTVLLSTGCIPLSESQFGLVTSLFTLGGLVSSFLISPISKHLGWGRQTCTTCSAIAGVVGSSILGASSTLPGLGLGRFVQGIGSGIGVVMVPIFLNEVSPIALKGSVGVLNQLSIVVGIFVAQAIGASWLGSDERYWRTVPLVSGALSALQLLGSFTVGLESPGWLEGEGRRKVGGAAEDRADEVRTLLWSPKELQGWRESRTAPRSTGRDDERQGLLAADSDADEPTREASQVGLSGLFRDPDVRPGAVLVILTQLGQQLSGINAVLYYSVGILGSILPALAGSIGILITLINIAMTFPPMLLVDEHRVGRKNLMVGSALVMAVASALLGAGIVYEMRSLSAVCMVLMVAGFSFGLGPIPFVILPELVPSRAVSTTTSLGLTLNWTANFVVGSAFLPLKNWLANFDSGHTGGAVFWIFSASNLATALIVARMYSYRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMY1</accession>
    <name>W3VMY1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMY1"/>
    <dbReference type="HOGENOM" id="CLU_2264862_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="103" mass="10881" checksum="DA854364DBA2B9F2" modified="2014-03-19" version="1">MLAATQETIGHDDVEDRAIIANVDADPLGAKVAEGMTGTFGVNIDIFTVDPIIDPEPVPVENRNPDPGAGSRSIHGLVGEESVAVTLPNDRSIFRSASRTLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN61</accession>
    <name>W3VN61_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_02709</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN61"/>
    <dbReference type="HOGENOM" id="CLU_021218_0_0_1"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="545"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="500"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS62940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="856" mass="90537" checksum="1F705D470ADCD91F" modified="2014-03-19" version="1">MNPQPPGSFDGVNEPVEPTRTPAEAQSVPVQEPLSPQEKQEVEEERQEAASLNEAALSIPDSEADDDAASTYEPANEAVPGDAGVVVGGGNPVDWQGVLGHSASGLGAANAATSAYFNFARTATAFGLNVAKRVTQGLVAVPALLADGALTGTAPGDTSGTPSIAQVAHSGIASFFDTISLVAVGGIDLTSAVTSAGLGAASSGVEGVRRSLGSEVLRSLLEFSKLVKREWNAEDDSLPPGGIPAYSIVGLIKALTTWVSIQLVTRKFQETRILQGLDEIDTDKLKSDVEALKQTHHVNVTAAPLVPITAGAQAEQSADAAQSGQSDVRITSNQTLSGDAGSVIGAEIGHRDGSSARLPGSTLSDEPARPLSDAEAVHNLQRYSKLVLGVYGGMALYWLNSMPQGGQSTSGQIDARAPSANGVIFSAEDELMRKDQAEFLEAAAQMELSDDEDDGDAATPPQAAAAATNGHASSYNLWDVISGTHDEDLFHHTANLERGAAAHGQYDEDHASASQRPPHNPNQKARPSKPRFYVVTDHPRKTIILVLRGTLSVGDVAADLTCESVAFRFDTSVQASIDKKVVTATEAEAPGRRGIFVDDAVQDLCHEGMYITAQEIGAPGRAVHRSVGAALAANPGYSIDITGHSLGAGVASVLAMMWADPTTGLTTASSRLPAGRRLHAYCFAVPCVTSAALGKKVSSIITSFTYSYDLVCRLSLGSIQDIRNGSAWLCYQDKMAAHGDGTMNALMKRAFEYQSGRMQEVASKETEHEMLVLRKTLEANMHNTHLFPPGKVLYALTSGADLLSEEGETHKKQRLFRVKDDKEALKKVFGQIIFSRNMLSCHMPNVYDARLHDITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP65</accession>
    <name>W3VP65_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP65"/>
    <dbReference type="HOGENOM" id="CLU_681726_0_0_1"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="466" mass="50272" checksum="27B2994F7B0D5D8D" modified="2014-03-19" version="1">MNQPARPLSFPPRPTLSTPPALQHEPLSMAYEVNASPSPAYADVESVPTIVAQRRITNIRKKQLIKAASRPFDDPPPPPKPDECCGSSCDPCVKTLWKEELACWRERWGSAAQEQPAATKKLVSAAAVDAEPTTTSMPGGFDCCATLHAPAYALFRTSINAALPLTPSHHSERSSVNMPRYTVPTLLPVALDNGQIYLESVVQDPPNASSCRGLAILAHPLGRLGGSLDDPVITHLASLLLTHAQLRVVRFNSRGVGKSSGSPSWTGRSECSDFQDLVLRCIDNFCLDFPDTSAAHIVVAGYSAGSLYGSTVRVPPSTYDLKPFRGGPKPRYILLSFPAGVTWALSFFTTKTYTEALKTLLTSRTVPGQGVGKGEEEGAAREESTPSNDAELQPTASHVLAVYGDKDQFTGIATYETWTRECSTIAVSASTFRHERIEGADHFYRGSGTLDALDRAVGDWLDSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP66</accession>
    <name>W3VP66_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP66"/>
    <dbReference type="HOGENOM" id="CLU_026724_0_0_1"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="526" mass="57508" checksum="7A741D25866799AC" modified="2014-03-19" version="1">MAQQYYGGGGGYPPQQPLQMQQPGSYGPGAYQGQPNGAQNQYYNGQQPPPQQYYGGDYKQPLKPEGFQGERLQPKPKWNDPIFLVLFLLVFGGFIALSVICLRGYSSSDISANIGQANVAGRTLNGHTAILFMICCAIGLVLSAIYIFLVRTFPKFILEATLLLTTLSNVAFCVYLWVRGNTAAAIIFTIFAVFSVIAYFFMRKRIPLAKVLLVTIIRTADEYKSVYVVALAGLVVETAFSAWTSWVVVATYQRFEPSGQASGSSSSNASVIGLMVFVVFAYYWISEVIKNVAFTTVAGIFGTAYYNATKVSNAAWGAFRRSMTYSLGSICFGSLIVALLDLLRALFNLLQSQAASDGDLVGTILACVASCCVACIQYLVEFFNRYAYINIALYGNSYIRAAKETWSLLADRGIDAIINDSLVNIVFNCGAFIIGLLTALFAFIYEQKTNPQYLQNDSGYYSIILLVAFGLGFNIALSVGAGSIASGVSTYFVALAEDPYVLQGKNPELFEMIRQQYPRVIQGVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPB0</accession>
    <name>W3VPB0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPB0"/>
    <dbReference type="HOGENOM" id="CLU_031618_3_1_1"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000078">
        <property type="entry name" value="Related to 3-mercaptopyruvate sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="55"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="212"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="351" mass="37735" checksum="115623276732A460" modified="2014-03-19" version="1">MLAAQTTRLTSQRLFSRLGLTGSGARAMSTTVRPATEPLVIAPKALASLMEKQDGSSKLRILDATWFMPNTNPPRSPLREFTVGPRLPKAQFWDVDKVATTGESVRNLPHMMPSAATFARAASEHGIEPETHVVVYDTHGVFSAPRTAFTFKAFGHSNVSVLNGGLPAWINHGLPIEEGEPSSAAKTDYPEPVLQDGIIRSFDEMVANAKMGARGQTVFDARSKGRFDGSDSEPRPGLSSGHIPHSLSLPFPTLLKTETGKDGKTYTVLKDQIELWRTLGDTVGGTEALDKLRQASSGGELAATNTCGSGMTAAAIWLALQEIGVQSSIYDESWMGWASRESEGVPIDKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPC9</accession>
    <name>W3VPC9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01833</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPC9"/>
    <dbReference type="HOGENOM" id="CLU_035188_1_2_1"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="243"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="315"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="417" mass="45626" checksum="D12C70A23B5EEDE5" modified="2014-03-19" version="1">MVVAMSGGVDSSVTALLLAQADAYDLEAVFMRNWNELDESGRMEPGSGGASGCTWQRDWEDVQAVCRHLGNIPVRMVDLSREYWTQVFEPALDEWRDGTTPNPDVSCNREIKFGALMDRILPQQASMTASTQSGDSSATARSGKTWLATGHYARVGWSPEARPMLMRAKDRTKDQTYYLSSVAEAKLQHAHFPLAGLPKPEVRELAAKYELPTAARKESMGICFIGTRGSDGKAISNTLGFSSFLNGYIASPPGDMVDESGRVVGQHRGLHSLTVGQRARIAGASEKFYVARKDTKHNRIVVVQGKNHPMLMCTRLRAAHLDWIWNEPPSELLHGAEGSVRLLAQVRHRQAETECIVTRDQDGQGSGYVVEFPEPVLAVAPGQVLGLWRGEWCLGSGVIQSVDTLHDDAAPPRAGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPD6</accession>
    <name>W3VPD6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2og-fe oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPD6"/>
    <dbReference type="HOGENOM" id="CLU_048788_1_1_1"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000041">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="217"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="323" mass="36537" checksum="1FCB18DC7E01D75A" modified="2014-03-19" version="1">MVKPSSFSPSALELTDKGEGTSKASSPTKRTVQSTLFNVKFGAHRTRLPPVKAEASPTKRTRSQYSLKEDEAKDETEEQSKRSKPASSAALTTSSATPKYHHRGPFHQVTRPEFCSAYQVDGLPDAEIYYKPDFISAHLAEEWRAELDRLSEWYRPKLKVYGREITQSRDIAAYSTAPGLHLKYSGHPVELHAPFPPLLNHIASLISSDDCLGSEVRFNHCMLNRYEDGSIYIGRHSDNIENKVIVTVSLGADRSWIMERKQPRKGSSQPSSEKVKKRWMLAGGSLLVMQGQTQKFYTHEIPKELKIKTPRISITFRQLVYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPH7</accession>
    <name>W3VPH7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPH7"/>
    <dbReference type="HOGENOM" id="CLU_702330_0_0_1"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="232"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="450" mass="48672" checksum="597AE08CEDF5306C" modified="2014-03-19" version="1">MWQRGTEAPMDTSPPGPRQPSIFDSDGSSGWTAHQHANVTQTIDTDMADVEMSSLTPPSHKFGDSRRHHLADAGPGLADDSMSDAADAAPRSHSSKASRSDAAAQNWPLASTSQHVRRKRSVLTRKGKRLAHLQSRDLVPSSRGFGSHQDDFVDDGDSIGTEGEDDDQDDDDDDDHGSRGSRQRGTPSRIRSITKYAVNYILPGAVSPLPHAQGGAASSVAPAHHMDKPELLLGYAQLVFNASILSAFLYLLFHVVRTVQKDVAEKVRAYEMDTLSEITACAAAYTANRCGTDLQAPALAHACSNWERCSARDPAVVGTARVTAETFAEILNGFVDSVSWKTMFFTLICFSMVVGATNSFLSFFRIKSRSRSHSDNKSQPTQPPAAASRQPHTHAIAGAPPQAVGAHASGMPHYYHSPHPDFASLPPYAYANWQQLPPATPSRRRTRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPL9</accession>
    <name>W3VPL9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01932</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPL9"/>
    <dbReference type="HOGENOM" id="CLU_037430_0_0_1"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="37"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="357"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="426" mass="45778" checksum="8327403F0E3C3A5C" modified="2014-03-19" version="1">MMFNALRTRASMARTMVRGGNAAAQKRYLSIHEHLSMDILNKYGIATPKYIAAKTPDEAFKAAQSFGGKEIVIKAQVLAGGRGKGHFDSGLQGGVHLIKTPEEARDLAAKMLGNKLITKQTGAAGRLCNAVMIAEARPPHHEYYVAVLNDRSTQLPVMIASNQGGMSIEDVAAENPDAIITTPIDFEKGLSKEDALAIAKKLGFTGVKQEEQAAETFQKLYQLFDEKDATQVEINPLAESKDGEVLCMDAKLGFDENADFRQADVFELRDTTQEDPDEVEAAKYGLNFIKLDGNIGCLVNGAGLAMATMDVLKLNGGNPANFLDVGGTASAASVKKAFELLLNSNQVQGIFVNIFGGIVSCKKIAEGIIQATQELDMSIPLVVRLQGTHEKEAKELIKNSNLKIFAFDGLDEAAAKAVESAKKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPP6</accession>
    <name>W3VPP6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPP6"/>
    <dbReference type="HOGENOM" id="CLU_1125188_0_0_1"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="215" mass="24284" checksum="2757192D29CA589D" modified="2014-03-19" version="1">MSAVAPRDDSAALMPPPSQPSTSASANTAVVDEARLTDDDIDALISSLQPHEELDQLRAIEKTIRETQSRRRREDEEMRAKMHALDSALSDLRKQSTRQAADWRSLAQHAETIEKLDNRNFDLAKKINEQESLLSSLQTELLELKRSAEELEEIDVEDESEMDKDATDATDEWSTLLVRSDTRNSAIHFDIHTAHLKQNEISPLVLADQLWKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPY6</accession>
    <name>W3VPY6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Opsin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPY6"/>
    <dbReference type="HOGENOM" id="CLU_054785_0_0_1"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32133" checksum="92FBF013E52FF467" modified="2014-03-19" version="1">MNSFYYDSVLDAFKKPDVTIPPIPPHLEHPIVSTQWGHTYLWAVFFIMAGFSVLFFISSQRASYRYRLMHTTTFFITAIAALSYFAMATGVGKTLTTIGEHRHGAPREFFYARYLDWALTTPLLLFDLTLLAGLPVAEIIVLVFADEVMIVTGVIAGVHPTKTGKWGFFTFSCVAFAWVLLQLVTSGRSTAFLRSPKVGGLYNQISLALVVVWTLYPVAFALCEGTGKLSPDKEILFFAILDVIAKPLWGAWLLIATPDEGHVLVPESLCAPAGSPASGGYGAISQEPRAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ47</accession>
    <name>W3VQ47_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Breast carcinoma amplified sequence 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ47"/>
    <dbReference type="HOGENOM" id="CLU_082523_1_0_1"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30022" checksum="81653F825A0A0FD0" modified="2014-03-19" version="1">MARTRGRAPNGSQASEPDEASSSASAAQLNGHDEQTENASSSTSSGDPFAYHPVDLAATDALPYFDRDLELQPGLRAKVDALIAAEQSTMPAVDPSSSRLPPAYVPFSTRPDLRAELERVGSSQPSSHTLDTQRYNLSAPEAGADASLEEWQTAVDNAHAQLGHMDVRLKNIELLKRYGSNAWRLSNFQQEQQIRMLSEQVEALKTETNEVNRLRQKEQTDAGAKLSVLEKRWTELISRGLQLEVANITTRGEIETLQSKKRKLEQQLAQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ86</accession>
    <name>W3VQ86_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_02720</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ86"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="167"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="384"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS62951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="563" mass="61610" checksum="65167020DE748DAF" modified="2014-03-19" version="1">MTTSTTEKALEDRVKSVHKKEKKDKSEKKDKKDKKSKKRQADDEDADGAGDADDDKAAKKRRKEEKKAKKAAAKASAATSVESTPAATPAPVASTSAAAFTPTNPAAARAFLETNNITIEAPEESNERPPLPMVDFRELDGKIDAAVKKTLDAQGFTTPTPIQACCWPVLLQNKDVVGIAETGSGKTFAFGLPALQHLVTKHKVLDGSSKKKAKGAQVNVLVVAPTRELAIQTEENMAKLGKSMGIGMICLYGGVSKQEQVRLLNQTPTVRIVVGTPGRVLDMARDGSLDLSNVTYLVLDEADRMLDKGFEPDIRAIIGMCQSREQGRHTSMFSATWPPAVRGLAESFMNGPVRVTVGSDELSANRRVEQTVEVLADGYAKERRLNDFLRSVNAQRSNDKILIFALYKKEAQRIEQTLRRGGFKVSGIHGDLGQNERIASLERFKTAETPLLVATDVAARGLDIPNVEHVINYTFPLTIEDYVHRIGRTGRGGKTGKSLTFFTEMDKAHAGELIRVLKDADQKVPEDLTKFPTTIKKKTHSSYGDHFKELVPGKAKKITFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQP8</accession>
    <name>W3VQP8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQP8"/>
    <dbReference type="HOGENOM" id="CLU_039184_0_1_1"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833181" description="Phosphoglycerate mutase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37811" checksum="CEA0FCB562C7441E" modified="2014-03-19" version="1">MVSSSHLVALLALACGAQAAPAWVLPFWNPFAMQAKSYSFSTYTGFFKYDTQEGTSLAAVAPNFGLRDNVTWDGLARTLLQLNIDGAAHDGSSYKLVFAGRHGQGYHNVAESKYGTALWDSYWSELTTDGNLTWGPDARLTPLGIQQAQAVHDGWVAMLKQRDSAPLPTKLYSSPLSRALSTMEISYDHILLNNPNATVETPAANGNAIDSILGGIVAKLGEARYVKPEIKELFREEYGEHTCDQRRTRSQIAKDYPNVRFEAGFSEEDQLWTTTREQDAHLDARIQQALTQVWNEAQQDQVISLTSHSGVMQSLFRVTHHYPIKPSTGALIPLIIKATPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR30</accession>
    <name>W3VR30_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01353</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_249811_0_0_1"/>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1191"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1260"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1294"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1337"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1360"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="1194"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="1406"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="956"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1035"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1095"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1137"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1478" mass="163299" checksum="2654BFA19F4EA2C8" modified="2014-03-19" version="1">MNDYPMDAAPQSLSELLQQSKKLTNHLGRSDLPQIQLGLDQIENQSRKLVSKSLRSGSTQPADARAHYFLANGGIDAAQLADTINAANIASTFEPLQPIYDTDVESYLTHEHQQVVISAIEQGRRETLQDFHRNLDRTMHRDWERQKRKIFEELGQHQPASAAGRDADLDASTSGFGASTSAHTLPSSSSTMLGSNATSQMHGKMARYLMVVSRLNSSRLEGYNLALAHAFIDAISGLGEESKNKELIESWKALASMVREQDVRNGEFGARLIKERQYAPAYVDLKGWNGTEGIHLRKELLQGSRAFLEKEFEEHMEQVIAANPVIAQRGGAPTVRSTVSAFLRVQHLSSQNQWRSDLAKELDASTNVPIWAELYLLLRIGKTKEALECASENENRIRSTDPSFLAYLKAWVDSPERRLPRLLKDRFVAEYNSRFRTLPEVHDPYKLGLYKLIGRIDVAKKFPALLTSSIQNWLWLQLSMVRETYDEDGDAQDSVRDRFTLADLGHKVEKFGEAYFDPKGNRPLFYFRLLLLCGQFEKAVGFLFSRSAHQVDAIHFGVVLAYYGLLRVPSQAASSQVEYLVVESDAQGGSVASIDFAKLVQRYVRTFSQSSRRDALQYLYLICLHADVAEPVGSEQVRRCHDLIRALVLEAHPTEFQELLGDVRTNGAKTAGLIERNLPLIKIKNEREFLSTIVQVAATQCDMAHRTESAILLYNLAGQHDTVVAVLNKELGARLMEPSSASEWKSEGLSSGASFSAASNVVTLATAILSTYEAQYGYAGKNRDTCRRLLELKKAVGLQSEGRYLEALQTIEALRILPLDGESRKDVVAITRKAEEFKEVDENIARNFSEIVLMTMTMLYKLHQELKESIHRSGTSAMDEYRAQARALMMWAGMLRFRMSSETYSQLTRLDVFGARGSIPPTTPILVNLDLNPRRTNTSGAMSHMIASAMSVAQQTLGSASTANDSSDHQPGLSPPLSPVGEQDIELTAPTPAAARASRRPATAPNSPMPPHLQSYRNNLGNDITIDVNIGPSTSSAYARAQGSAAFHHAHKHHPHSPSPSRAPLPSTAAPTEVAGPSADGKPAHLAHPSQDTEAAAGPSRSRASSLGYGGLAPATPGGETDPLLLRSRVVEESEVRRRHSGKGRNRRDERQIRDFYEAQNEHIERLLKPISAHADEDKQDRESSALKVKIAVYASIGANFVLAILQLYAAVSSLSLSLFATAADSVFDPFANLVLNWLHRKSEKVDERKWPIGGSRFEPIGNITYAALMGMVSAILVVESIQELATGDGDKKLFIPSLIAVGVAFVTKAILAIYCYGLRKYSSQVEVLYQDHRNDLFINGFGIFTSAAGATIAGWIDPAGALIISVAIIVSWTRTAFGEFKTLAGGAAPTDFLQLVTYNAALFSDEIQAIESVRAYSSGPRYIVEIDIVMHPETPLWKSHDLSQALQDQLESLPMVERAFIHVDHEVEHAFEHRKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR45</accession>
    <name>W3VR45_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02386</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR45"/>
    <dbReference type="HOGENOM" id="CLU_499783_0_0_1"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="46"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="212"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="420"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="545" mass="57264" checksum="C25CCE0CBD5E91ED" modified="2014-03-19" version="1">MSNPAGAASVPPPGMAGLPPPPPSFGAPMDQSNAEEAPPLPADAGKTLYIQNLNEKVKLETMKATLANLFSNYANVLSVTSHNNVRMRGQAFVALDSVEAADKARREAHLFPLYGKAMKISFAKSKSDAVVARETAESGGKESDDFQKHKEQRLEHKKMARRGNVLRRRELEKKIRAKRAAAGEIAEPEKASGAAAKRAQHDMPDEYLPPNKMLFLQKIPDGVGKGELESLFSAYSGYVDVQTIPGKADIAFVEFSDIPSSVTARGALNGYNFGAGDKLKRRAAAAFRRIDMSRFGGRFVPNIEHEVRRQATEPVAKWRQEWVIPSGTSDASSSTAVGVKILKWVRADTFATFPEEQDVQAEDRISDDAAIVEAPVQSIHNAPAVPTPAASLSVSGGLGTIAPKEPAPAVASAIPPHMAQVSEPTSGANTTRVSTPTDSVATPAAGEDSTPAPATAASTAVEAMSQGPSSQGEGTATGTGANTPQLQPQVEAQLHTQPTTAPTTDTATLAVLAAAGSAEHAETQPQDPAPATEASSSTDVDMNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR51</accession>
    <name>W3VR51_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01374</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR51"/>
    <dbReference type="HOGENOM" id="CLU_005714_3_0_1"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd16492">
        <property type="entry name" value="RING-CH-C4HC3_NFX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="850"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="936"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1143"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1076"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1154"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1182" mass="125883" checksum="AD109D5AE615B3F5" modified="2014-03-19" version="1">MSEASAAASAVQASLPALQNLNLSSAQASTSSAQPGREPSRGNNRGRGRGRRNDGSRADRIAKTADQNSSGADGTPSSSSAAVQEARKSNSKKKSRRGGVSKPSQSNGSATDAAGESNASQQDNAPQPRVAARRQQFGGKLTGGSANAGGAPASSAQQGAKASQNGRAKKPAVKVPAVAEPVEYADLRSRLLAELSSGEYDCVICYSTVTTRQATWSCSQCYSVLHLPCVRKWADSSVKKAEEHNAMQEDPEIRNRRGTWRCPGCQYAREDVPKIYWCWCGRVQDPPGGRGANPHGCGQRCSRGKCAHGCADSCHPGPCPPCAVTVSQKCFCGAQTIPMRCSQTAAKEARLSALHQRGTSCGGVCGKKLDCGSHTCEDACHPGECQPCSIQVDARCYCGKHTKTMRCGDGVPQLSFDDESASGFQGRFNCDGECRRPFDCGVHYCSKPCHARDPQRPVCPSSPSLVKTCPCGANPVASRTSCQDPIPTCGNTCSKVSICGHPCPAVCHLGPCPPCRVPVSTPCRCGETKQSRTCHERQQEELEGGQEVLCSTVCQSLRHCGKHQCNRQCCPLYFQAKSKSKKRPTLSELQALDPAGLHECSIPCSKPLPCGSHECPMTCHRGACPPCLQASFEELICHCGRTVLEPPVPCGTQVRCNFPCVRPPPSCGHPKMPHDCHEDEPCPPCVYLTDKVCHCQKHIVKNVPCSRWRVSCGQPCDALLNCGFHRCQGICHIAGQECPPCAQTCGKPRRLCQHACQEKCHAPSSCPETEACQAIITLQCACGNLQSRIKCGVSIHAPNKEKSLKCNDSCMIAQRNAKLAEALGLNPSEKTAPASYDYGTLAYYAVPANRKFCDELEATLNDFIRSPRAGMILPPANKFQRAFTHELAAVYKLASESVDQEPRRSVSIRRKQDSRIPKPLLTEAFAAARATLMSNQHQQSSSHLQSGKSVGLAQLQRPSAEAPKPLNAVFLPGVFGHDQDSLRSLLQPVLRTINFVVTWKGDEDVVVTSPDSPTRLIMMKTELKALLRREQFARDAILCTVDANKNVVRREDEPLLSNGGRASGGPARASLAMKRGGPGAGANGSGSAGLGKASPSLVGDRGWAAVASGSGRNSPAQVSEPVWGQPTMAAQVNSVRTTAPIAGIVPNPNAPRQAATDVAATAPATEASTAEGPVPESWEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRF6</accession>
    <name>W3VRF6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_01642</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRF6"/>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000025">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833207" evidence="13">
        <location>
            <begin position="30"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="44"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="175"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="401"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS63361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="630" mass="69183" checksum="79F36554B375AC3B" modified="2014-03-19" version="1">MVRATTSAALPAVALLACSLASLIPAASAATVEHHWNINWIPDVNPDGLLPRHVIGVNGTWPPPIINVNASDTLRVTATNNLNTGVGTSLHSHGMFFNRTGYFDGAVAITQCPIPPGESLTYETLNSPASPADRRKQMGTFWIHAHNNDQYTDGLRSPVIIHPDDPADMHYSYDDDYTVILGDWYHSNYTDLVKNEFMNRKNPTGAEPVPKSGLIYFAHTPNTTTAATYLPGFSENATLPFEAGKTYRLRVINMSALAAFYFYLSGHDMQVIEIEGVDVEPRSVDFLSLAVAQRFSVLVKARNDTSPQNWKLHANMDEDMFDVVPEDLQLNVTATISYPNAPKGEFGPEKIIEEYTYFDDLQFTPVNAEPMVQPDATHRLDVSFDTMSDGENYAAFNNISYVAPKVPALFTSESMGALASNPAIYGPNANAFVFQHNDMIEVQLFNWDAGKHPFHLHGHHFQVVHKSQDVTSDDPTINPPFNASQVNPMRRDTVVVPPGGSAYLRFRADNPGAWFFHCHIDPHLVSGLASIFIEAPDVLSNDYLNVPSYIKNQCQAQGIATTGNAVGLNSTTDFQGLKKGPTYLESGWTGRAIAAFTGCIVTGLLGLATVVVYGWHSGEDEDVDDDEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRJ7</accession>
    <name>W3VRJ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_01694</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRJ7"/>
    <dbReference type="HOGENOM" id="CLU_1396888_0_0_1"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS63411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="195" mass="21533" checksum="922E996F1B111EDA" modified="2014-03-19" version="1">MPEPSHPMETAYFRQNFSSSLTSSLLYTNFSDEKSRTRPGRGSARAVAALTVTCVFASPLAPPLHHRLHTISHTYTMFRQALSTSARPAARCAALQRGTAAQARFASGGSSYNQPTGYLFGEKVPKGQKRQKENWENMWYFGMFGGMAFAAVALMYKPDTSIQTWAMAEAKKRLEASGDEWQYKPSPNSGHPNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS37</accession>
    <name>W3VS37_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS37"/>
    <dbReference type="HOGENOM" id="CLU_2039034_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="121" mass="12653" checksum="1B280F910EE2824E" modified="2014-03-19" version="1">MQCASTHEDQRALAFPPTSAAGAPGIHTRDQPSGAVSRPVSGVRQAKASSAPVFGLPSKAASGHQRATQAPPASVSISEPEQRQHSHGRLGAWPPFPPYKATILRGATRLGSERELGAGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS76</accession>
    <name>W3VS76_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS76"/>
    <dbReference type="HOGENOM" id="CLU_011290_1_1_1"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="10">
        <location>
            <begin position="65"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="9">
        <location>
            <begin position="615"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="842" mass="92716" checksum="76D7C5766585A4B9" modified="2014-03-19" version="1">MLSTLPSRSLARRIYTSSSPALASLPRSLLPSVRPTLRSGSPAPARMSSSTSNAPGWSTQPKPYPAARRDDSASLTYKSAAKGSVTVPEPYAWLEQPPSQSAETKDWVLAQAKLTQNYLDGCQPDLDILKSRIQKNFDFARFSCPSLKGDGRYYYSYNSGLSPQSLIYTASKQQVDANAGKNQRDPIGDIFFDSNLLSADGTVALSFTTFSKSGKYMAYGISKSGSDWTEIFVRETAKPFKLDDKHYNPNGTIRLSKDELAQYVDATGGNDRLADRIENVKFSSATFTHDDKGLLYQTFPSASVSDKGTETDANKDAQLWYHRIGTPQSDDVLVVSKDTKVPESMWSTNVTHDGNFLVLYNSKDTDTKERVFVLPLHGKGLNAADKLKWIPLALSFKYVLNYVTSKGNRFYFMTNKDAPNYRLVSVDLDPATQAQETSNVWELTGNDVELRDVIAEDKDALLSSVQVIDSNKLLVVYSRDVKDELYQYELETGKRVERLLPDLVGTIDQIAARHEDDHAFVKFGSFVNPGQVVRLDWQAGSAPDAPKAKQTAYYDTQVEGIKADDFVSEQVFITSKDGTRVPMFVTHPKTVKKDGSAPAILYFYGGFNIPITPVFSPSMMSWIASYNGVLAFVNCRGGGEYGDKWHEAGTLLNKQNVFDDALSAAKYLHESGYAAKGKIILSGGSNGGLGVAACINQQQPEHGIGAGIADVGVMDMLKFHTWTIGKAWCADYGNPSEDPEIFDYVYKYSPLHNVDANKVYPTTVLACADHDDRVVPAHSFKLMAEMQHKLAANPNPLLLRVEIDAGHGAGKSTQKRIQEAAEKYAIVGRALGLKIREDGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS95</accession>
    <name>W3VS95_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Map kinase pathway-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS95"/>
    <dbReference type="HOGENOM" id="CLU_016105_0_0_1"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030160">
        <property type="term" value="F:synaptic receptor adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09533">
        <property type="entry name" value="SAM_Ste50-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="6">
        <location>
            <begin position="413"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="566"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="777"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="792"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="848" mass="89408" checksum="2C34FA793731F320" modified="2014-03-19" version="1">MTSHSPKSSPTLHINKWSEQQVADWLSTIGLAKYGRDFISNGITGDVLVLLDDEALKDIGVVTIGQRLAMLSAIYRLKTQFGIPIHDGDWLPKAVEAQEHASDTLSTAHMASALRQRDDRIRLLESQILRLADYLARFQQDMASVARQVGVKAHSIDTPITLVSNSLHSQQTSDSGVSGMSTYPSNPDLGSTASSSLPLESPTSRHFTGLVSPTRSGFTYPAGHAMSGFKPATVTSARSDSIGANSPMTPTTTVHPHPPTSTGAPAGASDLSPTQSTPSATPTSLGSYSGFPQQGPQIHQQQPPSSAGAGSMVSPTRRLAHQHAISQSDAAGPSRPRAGSLGASNALSSAAASPFAPASTNGPSSNGASVSSTDREDRKDAALADSNEPKPKATTSAGSSTAASAPVSASASSSSSDSNPYKSFRVTLDDPCYKVLPAALKKYKINDDWRKYALFICYGKTERCLSYDEKPLLLFQKLKENEQSPVFMLRHIRDVKSPIAIAEAKAASKLQERDGDAAANAKKRTAVRTDRRRIIAGTPPPGALVANTSSPVEVGPAAELPERNKTARTYAVAIYPYMPERDDEFDVNVGDTFIVINKAKGWWIVQRDAGGDGSGDVVYSVPVGEGGPTDDDSTTTYSNYRAEYASGWVPAGCLLETSRPLGSIVDAEVISSRSRTGPSTISNPSTPTVLTMGGDGTRMDAKRAAIPPALITSTSTPGVMLMDYQSAEGDLDLRKDERLRVFKRYNHWSYCVQERDGHARGWVPSWYIGKLSASTGASATSASGGRDALSKVGSNNVLSPSATGNSSNMDLRAAQLNADGGIGSPSYDPSAGPAHDHSSEAAPAIASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSI4</accession>
    <name>W3VSI4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSI4"/>
    <dbReference type="HOGENOM" id="CLU_016785_6_0_1"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="174"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="409" mass="45509" checksum="AB82E413ADA855E4" modified="2014-03-19" version="1">MTSTSALPHPPSMSENDDPFYLLLRQRAVEARRKQGIPLSSQAATSESWPQRLPAPPSSQQFRDIVERHVPVLIQGCLDDRPQLAKWKDTAYLQSCMGPERSVVVALTPDGRADDLVEHHESGREEAVFALPLEQSMRFSELLDRLARQVAGNSDSIAYLQSQNSNLSMHEYGDLSPLLRDLEQTSEADASLRSDLAWATEAIGCAPEATNTWIGTSASRTSMHRDYYENIFSVVRGYKEFTVFPPSEACFLCDDDEYPIYRYAEHTPADAAGKKSLVLKRDADGAATRWIPIDPTLPKSAPRNAPYVHRDLNADAQSSLPSRPHAAHTKYGYALPALTIRVHEGEALYLPSGWFHHVAQQHDHQLVAADPAPVNRGLCLCINWWYQISDDVALQLDEMDLASGYTGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSK2</accession>
    <name>W3VSK2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSK2"/>
    <dbReference type="HOGENOM" id="CLU_039758_0_0_1"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="521" mass="54708" checksum="1FCB0E7A56040F96" modified="2014-03-19" version="1">MPSSTTSTPSSTQLEDPLPRPTVVGGSRSSSRSSSRNQSVYSSAPHSRSNSPTPPQDGAGRSRSRTSSRRSSLAPGPSRTRSSTSPQRHPMRAVDPNIVVEISSDSSDDDDVVPVGPAFVPRPSSTSRANDFVEVSSIRRARAAPPTERSNLFSPPAMNGPPAEPFLFSHVRSGRNVGLSVDPSTGDFLTRPMPIVRSDRSISQSDDDSSFSILSARTAARPAPAPPPARSEHPITDMRLRSSNLAMPTKSPPRSKPPPIEHPLLSKYTCPICFDAPTNLSVTPCGHFFCGGCLFQALKTQAVQRGAMEEEQSFLRFGGLFAPDAFPIDREAFSEAVSPSGRSAGAVGATSAGRGRGGRGGGASGGRGRSKPDPLAGQCPVCRAKIKGGFNGREKSGILGLRLTIGKPVDDPREESGKMKGDSAPGEDASADSSETEDEAAWLSSRKVKDASKDSKSAEQQQPQHGAGSGPALGRGKRRPQRSSTNALTSSDRSTATAEGSRGRSSKRQRHASSSSATATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSP6</accession>
    <name>W3VSP6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication factor A protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSP6"/>
    <dbReference type="HOGENOM" id="CLU_141922_1_0_1"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12198" checksum="C19C5A886E3C06E4" modified="2014-03-19" version="1">MEKPTPMINSAMLAQHAGQTVRIVGKVQKLTGQTLLIQTSDMGNVEVALNPDSEISGSTFVEITGKVSEGGSGLDGHLVREFTTVDCGENVDMELVEKTVQLSNKFPNLFSDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSQ8</accession>
    <name>W3VSQ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSQ8"/>
    <dbReference type="HOGENOM" id="CLU_131047_0_0_1"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="171" mass="18324" checksum="BC3E8F218837260B" modified="2014-03-19" version="1">MSFLARNTFTQARSGLSRQAASASAWGIRQESSSAAAKATVASGSSSSESSPATHYRITLRRSGIGMPDKINRTLQGLGLKKRLQSVYRPIGADMAGAILAVKELVHVENVRRLEEADQMLLSDEEAVWLNEAGEIVDPGKAARKAPRGYKVVGNVVSELRDQQIKNGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VST9</accession>
    <name>W3VST9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_01042</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_231732_0_0_1"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="251"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="13">
        <location>
            <begin position="345"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="632"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="832"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1337"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1573"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1625"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1847"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1915"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1352"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1580"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1643"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1678"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1730"/>
            <end position="1754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS64575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2154" mass="235110" checksum="FAF60A0209AA1C35" modified="2014-03-19" version="1">MQMLTKFESKSNRVKGIAFHPRLPLLASSLHNGSIQLWNYQTGTIYDRLEEHDGPVRGICFHPSQPLLVSGGDDYKIKVWNHKTRKCLFTLNGHLDYVRTVFFHHEHPWILSASDDQTIRIWNWQSRTCIAILTGHNHYVMCAQFHPKDDLIVSASMDQTVRVWDISGLRKKNTSAQPMSIEEQIARANSGQADLFGNTDAMVKYVLEGHDRGINWASFHPTLPLIVSAGDDRQIKLWRMSDSKAWEVDTCRGHFNNVSSALFHPRHELIISDAEDKTIRVWDMGKRTAVQTFRRESDRFWVLTAHPTLNLFAAGHDNGLIVFKLERERPAFSVHQNTLYYIRDKQVRSLDYATGADQALLSVKRLGNQYIPPRTLSYNPAERSVIVTSVSGDQGTFDVAPLPREAGGDLAESSSVGKRGQGSSAIFVARNRFAVLDKAAQTIEIRDLNNAVTKTITPPQPTNEIFFGGTASLILSTATGVILYDIQQQKTLAELTSPPVKYVVWSIDGSMVALLSKHTITLADKSFASSNLIHETIRIKSAAWDDSGVLLYSTLNHIKYALPQGDNGIIKTLEQPVYLTRVKGKTVSCLDRLARPQNIQIDPTEFRFKLALVQGKYDDVLTIIKNSNLVGQAIIAFLQKKGYPEIALHFVQDKSTRFDLAIECGNLDVALETAESLNVDEVWERLATAALRQGNHKIVERAYQRTKSFDKLSFLYLITGNTDKLAKMAVIADKRGDHLSRFHNALYLGNADARASVLADVGLPALAYAAAKSNGLDDRATAIAAEAGMEEEAAEVDRQLSLGEGSSKLAPPTAVSQAFQYNWPIVSTEQSYFDRALVAGNEGGPIFKDNALNGAKTHDIESWLDGEALEESEDDEDQDALDAEPEDFGEAEEAWDLAEEEEEVALAEQEAAVVAPLQDAPLDGLAAGSSEAEHWLRNSPVAADHAAAGSVETAMTLLSRQAGIVDFAPLKPLFLSSFLAARSYLPAAPGVGPIEVHLRRNNEESDGKVTQAHPASPRSVKALASGELQEGYRAVSANKLAEAETIFRRLLHQLVLTPALSEAEATEIQDLVVLCREYILGVSIELGRRKLMQTEPDNVARNLELAALFTHTQLQPQHQTLALRSAMTEARKVNNLAMAASFAKRLVALSPAPAVAQKAQQIISLAERSPRDAVEVAGYDPLEQTFVICAGSHRLIAAAGAGSVADPLTGARYLPEFKGSLCKVSQISEVGRLASGLRSFANMACVVWVRGQDGEGDPALGIAKQHFELSQHPHLAFAPQPNPHSPLLFAGEGMSFLPSFTALGASASTASSSSTGPTFKPASLSYFTIFCPALKPPKSRRSQQEDEEEQDAEAREEERESAQILFYTSRARAAPKDRMLRQIGVAKGMIEFCSMVHPTPSDTAERGRTWNVHSSKRRMILVEVEAGVWVHASIDLACTTTSSPDAKPKREFHDDLLPDAWLEEGIRRSWTDWTLLNGGPAHLLSQNTGRVGLERSLEKYFSVWAWSWDLEAATNAGSTKQHRLFTECIQAYPVVPRGPRERIEELMRSDAAQRLQREREMIVLSDTQLLWPPSDAGCFDDPRDARPEQQQRDAEQMDAATKAELLRRVVSHLTGLERERELVRAAAVASTSDGRRRGTSGAIRERGSSSSKRDVRTGLLSNGTGAGKMRVVSSPAMQQRSTSASSQASTTSDSTRWSNWGGMLSGLGKLGLRSSETPARTETPEPKPSTEPGASAISMASSGGDSGKVGDVASPLGSLQDAGEKVWNGAELALRGLGASLGLANASARSGEDGAATRETEATDQERFADASFDTSGAEADASVVTKVSILEPEVDVDELAEALGAEGAEEASHADETAAQQDEAERVASASQRVDDRDADAASIGTSASAKAFPSISVTSAAWYSKAVGSEATVSTNSPQLRTGGDSQGASLGGGQHHDFELDGWGHETAQPFESFRVYVGSAEEPLCYESVLALQEEPLRCTPYRVLFTTRRLLTMVLIERLASDSGSRLSVTSNDLLDDAWMVLRRMQRLLNDHARSAPPTSDSVGFVHIDGLTQTMYSTLWAAGEKDAEVEVVADAHCVSAHELMRRHGVLETFSRSSQGKTWTASRQRLHKEGGGASQTYMVLAGKKMSIVDCDTQLRKLAHQYPSFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT31</accession>
    <name>W3VT31_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT31"/>
    <dbReference type="HOGENOM" id="CLU_054974_0_0_1"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36226" checksum="F9F463D8E6D65120" modified="2014-03-19" version="1">MSQQHQEKKKKVVSIALLVADTPPPPVVAVRGDYTKIYPRFLQESLNTIKRHPWQPHVELHIRCYDVVNKMEYPDEGQLGDGLWDAVMITGSASSAYLDLEWTKKLAAFLRATAENHPLVRLIGICYGHQILSRAFDGVVEANPKGWELGTTSCTLTEQGRYLLGYDEPSEGDQMAIQQVHKDHVIDLPPDFGGESFENLASTDISPIQSLILRYPTEAPPLASTAQTSAYMAFDIEDSETASSGPHPLRNMHVLTFQGHPEFDREIVENIIEVRTEMGIVTGELRERSLANAKKPHDGLKLGRAILAMLGIEEARTDSGDSMINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTD2</accession>
    <name>W3VTD2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTPase-activating protein beta-chimerin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTD2"/>
    <dbReference type="HOGENOM" id="CLU_003874_0_0_1"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000160">
        <property type="entry name" value="Signal transducer, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="910"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="980"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="775"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="863"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="550"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="704"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="815"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1172" mass="128122" checksum="4892603DA4C31F3F" modified="2014-03-19" version="1">MPALAHDQTALRDRGAPLVPSSELDDALHNHDADEELPEAYCGGCGRLIDEESVEEGVIQFATKLWHIECFRCAKCKNRVSTERDDILLLSDGHPICGECNYSCNICNQPIMEEAIMTGDESYHASCFTCRSCHSKIEELVFAKTSQGIYCMKCHNERVARSRKHAEHKRAKARREKQLQDAHNAEAKQQALSSAKPAKPANNAPSPSSPPEQQPPSLPSKSPAVSATTPSSSAVPSPSPNGASLSPWMHQGGSAASAAASRPGSAGGKRPMHAPPPPNRDARSPALGSLAKLEGRSLSANNTSNTSLTSLATDDASNPYETTAPLSPRKNAFHATVSSPQGSPAGNKSRLPPSTDATYSSSSPTTSPLKKSLPLQASPRTSSRPLQPSADRDALGVSLRSTTTAATSPRNPLQASASSSRLSKVYSFYDPDFLNLVESFGDFDSNDELRAQPPPVPELPASLPSASAVTEPLDTKSSHDHATTARADPSLDEHDQNNGADSPDSDQELLDEDRPRTQTPTGSLNEVSNRVRASMQQARDGLVSMDISFVETILRDLEDTRQRMESLQTRYDRIRRASQQAAHGFSMAKEEFEHEVNARHEAELEMARLRRQLAEQALKLATANSERRQQEQLERRSQDVKASLKGMERDLAKLTVERDLTVAEVAELMALQDGATGSSSVLSSPNMARSSTSTSDAVITQNLASRLESVKNRYRKEIDELTMERDSLLIEIEELKQSKELFLEEAQSLNAKNEELNTVLGQLNRKIELAAQSRDQLPPLPTIPRDLASSATKSSGGFSFGSRHKQLHKHTAHNASISSDAPPSSAGYDVSVDTAVQQVIQPGKIEPAPVVKKFKWMKPKLSETTRNNVPPAGHVPPVPPKGGAGLAVPSASASTTSMTRATSHDVVVREHLFQPFNVLRPTRCFACQKNMWGQSEMRCALCTQVCHSRCLQSLPVSCNQPYTRPDESVGDNAGPSMFGRSLVEQAAHEGRDVPLIVEKCIQAVEAFGMDYEGIYRKSGGTSQLKVITQLFERGNAFDLEDTDRFNDVSAITSVLKNYFRELPTPLLTFELYDELIRLVESKQGDAGAKQEMMKELVTRLPRQHFCTLQHLVLHLYRVQERSVDNRMNARNLGVVFGPTLMRSADPSQEFAHMGGKAMTIEFFIDHAPDLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTR9</accession>
    <name>W3VTR9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001983_0_0_1"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="498"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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            <begin position="225"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="282"/>
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            <begin position="413"/>
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            <begin position="1441"/>
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            <begin position="1864"/>
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        <location>
            <begin position="16"/>
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            <begin position="80"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1943" mass="200727" checksum="C8B04D8E49D40BCF" modified="2014-03-19" version="1">MIKPPAMGVFARDPPSNARAGAPASTAPSANAVTSAAATGATSAFAAAPASPSALQPQPSPFESRMDARLIGLPSQASDDTAEDAADVDDDGAAQDDDDQGTVDEEAGIIRCICGCDDDDGFTIQCDRCLVWQHCACFGMSQASVPDEYLCEQCEPRPVDVAFAQAHQQKRKNNEARKALMDRNLKRQAQAMASNSFNQAYLAPESAPSPTSSNPLSSSTAAFATDDASAPLPPTTTAAASSPSSSSAAAAAGTAGAAAVRSRKPSHALDLTNTQFVVPEVPASAGASQRGGKQRKGHKGSRRGYDTPSAVSTPVRGVFTPGSAHERADDPFDAAEQLEAWHVEFTPIAKNVVADPSIIPDLAAAMLDWEEGSPLKAVSGPAGRVLVPSLGSSSIATSNRHLASAKPSRFDLHASSSSASSPSPASPHAPASPAEFEPSPLGISAVGDECIAIELIGPSLANLACRTYVKQISESASAGVFTNLLYASNSADEPQRAWCASRAFSRPVMHGLFAEASIPAGAFISELRGELYSATAYRNDPINQYAALGATKPHVHLLPPPLNLAIDARRFGSEARFARFSCHPNAVLRPILFRPNGQPSARSRTSSRAQSPSPAALLARQHRYADTPPAESRSDEPQLLFGLFALTDIPRTHEITLGWEWDDAHIVHFLPELVQNPYLESRQDDVDPSQHTANMVALAEKGEFPYADTEFSVKMSTVSAALLGCVLCACIGSAAPPGGGGGASSNNGRKQDCAVAQMLRVGNGMSLLNVTMPGKTNRSRARLPDFSPLVGTRRFWRPYSLPPTPEVSLKDEDSPAEATLLGAPSSDAEADMARFFDQEGEAGCGGIESVEAANKARLKSRAKHAEDAMDVDDDDRSAASDVDDTDDARSVASSLTDPLSGLSDQETLSEGVDEELMYALRQVDGVRAKSRTKKGGMRKDAADADAELSGLFLLPPKKRSMRTRIKASIAPSDEEDAGDEHDDDQEQEAKTKSRKSDVADKSKSAAKRKSANRPAIDFSSDEDRDSDRYSATTPVKKRRKSGNVANPSSPLSSVPSPGSIDSSLSTPPPVPRLSAKHRVENERRLSDREFLKKKRSAKQAKDRKAKSSDSRPKESASNRRKREEARIHRNAILDLGDTESSEEGLTDRDDAESSNKATARDDASERGSAASTPRTSKVGLPAESAQGPREAKGKKAAAVESPKSAAKDTPSKTKKVRRILSDSEQSSDDEGKAAASSPSVHVKALPQVKDEEAAAQPTATAQTVADVPMPDADAAAPLELPAIATKEEGSEAKDAPRGPAPVASEIAPAPAAAPASLPEVKKEEPRVKLSLAEYKRRLAERRVSEQQPASTSSASTAATSIPVLATPTSESAPSPSPAVEKVDPVRARPSVSSELLTSEAVSAPAQPTSVPVEPRSPEKSASALPRGVLFTSIAAPTAIRSVEIPKSPSPEPPSLASAQQPGQVGATAGGAAASSEASATTSAEVSAAAGTGVDATRARAPSVTQQPVGQSINTAGVNLAASEGSVKPQTPGAVATTPGAGSSSTGAAAVAPSAAAPTPSPTFGPTRYPGSRVPSSPSGPSTFNPPKAPRAFMSPPGVSAPAPLTSTSAAPPSTSAAAASAPITTSASAGVAATPARSVVGVGNTPSTASSSSTASSRYPAPGLTSPTPNATALPGYAPRAFAGVPKGPASMRDPDPRADAWAEAREAREAREYPGARHLDTMRDGGRDMGWGERSREPVGDRDGPRGGWGRERRDMMHRGEPMGREPYARDGRFFGRDERDGAGAAAVPPAGSGGAGGAAAGAGGGSALGSRLDHAHAHAPYAPYRRPSASEYDELHGGAGAAGYDPYNRGIVVRGRSLGLGGPGASAGPGGPPGAGGVGGREGRGEYRDYDDMGPGAGGQQGPPMGAAARGMPGFRSGWGGRSRPRGAPGGGGGRGRGWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTZ3</accession>
    <name>W3VTZ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_00566</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTZ3"/>
    <dbReference type="HOGENOM" id="CLU_008213_0_0_1"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="440"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="656"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="304"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="903"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="909"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS65108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="926" mass="102141" checksum="8B5FAB30E7BD2C8C" modified="2014-03-19" version="1">MSANEGSRPRITVKLRPNANSASASTSAAASRAQSSRGTPVSRRADDDDDDEDGEQAFALDDGFVSDDSGDEYGSSRRTGRGAAATAMKVKAADAGRAAPTSAIARQHPLSGAAPRFNGPAMDEDDEQERFESGELRFHTRDFTKMPLKLDHASRPLWISPDDGHIILEGFSPLAEQAQDFLIAIAEPVSRPAYIHEYKLTPYSLYAAVSVGLQPNDIIEVLNRLSKVPVPDAVLDFIREYTASFGKIKLVLKQNKYFVESAHPEILQTLLQDSIIGAARVREDPNAARSGRMEVLGKAQAPTRGDLVIPGTEGAARKARQQAGNAGQAPGAAGAGGSGASGSGPQPESAEAARREDEADLFSAIIGVDEADELDEDDTVHSFEIVEECIEQVKKRCNEIGYPMLEEYDFRNDQLNADLEIDLKPITHIRPYQEKSLAKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSCLVLCTSSVSVMQWRQQFLQWSNIQDNQISVFTADQKEKFSGASGIVVSTYSMVANTGKRSHTSQKMMNFLESREWGFILLDEVHVVPASMFRRVLTKIKAHSKLGLTATLVREDEKIDELNFLVGPKLYEANWMDLAAKGHIATVQCAEVWCPMTPEFYREYLREKSRKKMLLYCMNPKKFQACQFLIDYHENRGDKIIVFSDNVFALEAYAMKLKKPFIHGGTAHVERMRILQNFQHNPIVNTIFLSKVGDTSIDLPEATCLIQISSHFGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTAEMFYSTKRQQFLIDQGYAFRVITHLVGMEDMPELVYKKQSDQIELLQSVLIANEADADLGSDMHGTEFGGGGGGARRVGGVGASANAAMPKAARTTGSLNALSGAQHMSYIERNRSVNKTLNKDQGRHKLFQKRADKAKRKNMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU56</accession>
    <name>W3VU56_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="13">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00493</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU56"/>
    <dbReference type="HOGENOM" id="CLU_060216_8_0_1"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="14">
        <location>
            <begin position="62"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS65040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="225" mass="24504" checksum="CB9BA00818C5A374" modified="2014-03-19" version="1">MSVTVPGSLGSLRGLAARCQPSGSASALPALASNTARATSAASKAVHLSSRAISTADKSQDLELTLALIKPSVCSYQPDVSAILKEIKQSGLNVARSKRIFWTSSDAHDFYAEHRGRFYYDRLIIGMISGPAMALALVGPNAIKRWRAMLGPTKAYRSKYEDPQCLRSRYGLGDTRNGFHGSDSPESAARELGLIFDGWDTNWWLQREQGRLPTDQDGKLNPLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU91</accession>
    <name>W3VU91_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU91"/>
    <dbReference type="HOGENOM" id="CLU_909718_0_0_1"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38848" checksum="3BB0EB75BACB75A4" modified="2014-03-19" version="1">MPLNTTTFLVSQGWEGVGVPLDGKAGRGLKKPLAITQKKTLSGIGKDRDRADDWWNSIFTAGAKSLSIGPSPASSGASTPVSASNGQKSSSSWNMGERSAASASMSLSSLAKREHARKTLMSNFVRGKPIVPAVEETLPLKAAPSSPPTLKADDTPAASDVEVDAALNVVSPSSSSASASSVPLSKEEKAMKKRQKKDDEALQKKLAKKALRKKLKESQGLAPSSTPASESSAEPVVTSKDKKSKKSKDAKEKPGDREGKKEKKTKTESSAIRDPETHDDDDQKDLGSSKKRKRDGEAEAISDKKAKTKKLKDEKSDVKKEKAEKKEKKIKKEKSKKDGEAKAEKKEKKEKKKKRKEVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUJ5</accession>
    <name>W3VUJ5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUJ5"/>
    <dbReference type="HOGENOM" id="CLU_116420_0_0_1"/>
    <dbReference type="OrthoDB" id="5376498at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="164" mass="17178" checksum="EA9D3A5BFEAFED30" modified="2014-03-19" version="1">MPASLTEAKDALVLRLKFHKSTLFLPCQPADSLASLKAGFVSAVRSSNQPELSSLPPYSTADAKSYPSWSDMDPDTDVGLFIASSTGNDAAGLEGMTVFMPLEHDATGADTTVRKAGLKDSDAVCVGFRAQGAASISQPVVQFTDVEEDDEAADPDSVPPPLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUS6</accession>
    <name>W3VUS6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00294</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUS6"/>
    <dbReference type="HOGENOM" id="CLU_029048_1_0_1"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS65225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="493" mass="52607" checksum="EBF0F7A47D4EFC64" modified="2014-03-19" version="1">MRSQTAPGSLSGSTTMGAQSMQRRTAGSKPPAATATSGSTLVQDAAASKPPSRRQLVAAQTRLLRLSLWVRIASVGALILNAQLQQAFDTSHELLAFALDPNGAHGLSTGHFRWLLAFVRWDTVYFLAAASPTAAEGLHVGGYRWEHMLAFQPGIVALLRILGYVTPSLDGSWSPTSAVLLAATLANVAAVVAPLLLFRLTLRVTEQIELATAAAVLSVFAPSAATTLSAPTPEPFFSAASLAGMLCLEQARLGWTRLLAASVWFGVATAFRANGTLLIGYTAYKLLAQAGTRGFAKAALQLAVSAAVCVSPTVLFQTWAYGRFCLAEGGRPWCSAVPPSVYAFVQAEYWHVGWLRYWEVAQLPNFALAAPVLVAIVATARRYYRTSSRAQLLASLLAAHPPAQRRLGFTLSSVPRAVPYVVHGLVLAVVLLFASHVQIALRLATPGGMPMVWWGLAHAVLYAPPWLRPLVLSYLGIQMCVSCVLYAGFYPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV40</accession>
    <name>W3VV40_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV40"/>
    <dbReference type="HOGENOM" id="CLU_070152_0_0_1"/>
    <dbReference type="OrthoDB" id="2553198at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="245" mass="26627" checksum="98DAA65AB84EBCBD" modified="2014-03-19" version="1">MLLSPAVKTSYLNTMAGGSSPTPKRRMEGEETAETSPLSGKRARPTMPLRGSRSAASLQFQQQTPVHPPMPVRSMSEFAQDPFASSSDITLDDLSAPQQQNLQRDIFTHSSATSNKGKGAEAAPSPVFTSNNPHWLKVVTSYGYTFIKSDELHLLDGNADVQMVIESNQNEVPRSPPAQMRYPMGLEFPPTPSPSDDGNGTPAHRYFAQQHAGGKPLWEHVEGDCEAARAQAAAGGINEMMMDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV42</accession>
    <name>W3VV42_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV42"/>
    <dbReference type="HOGENOM" id="CLU_053603_0_0_1"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="305" mass="34008" checksum="0E51D08F3A95CDA3" modified="2014-03-19" version="1">MADRKALNHYYPPDFDPSKIPRRKQPKEQQQTVRLMAPFSMRCNSCAEYIYKGRKFNARKELVVGQDYYGIKIFRFYIKCTRCSAEITFKTDPKNADYVAEHGASRNVVPMKDDRAEEGDELLTEEEKLERKLEKMEGDPMKQLEERTLDSRREMEIMDALQDIRTRNARLERVDADAVLAKLHDRPNGPSGSLASSSAIEGQEQAQAAEEEDEALVRKYFGKALDGPSLSANGSASGVTVKRKLLDDHEAEPDVHTLLALKAASQPSAAPTHTSASATPSASAAPPAKKKKNAPNAFGLVRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV61</accession>
    <name>W3VV61_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000498_0_0_1"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="161"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="8">
        <location>
            <begin position="1511"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="598"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="755"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1457"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1475"/>
            <end position="1487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2093" mass="230911" checksum="1C4EF3027EB7697A" modified="2014-03-19" version="1">MIDELVHHCINEIGLDGEAGTEINRLTSFICQFHADHSSRSQLPDQLVDASYLAFVFRQLIAHPDVNVGLFVAGVPQREGARTGITKRKASAPNTPTTKRESQHQPVAPEYDWVETLDPSPAEHHGLPQLQSAHGDRLRLVLQPAAIKRQLVGADDIFLPPSAYNVLQIICRSRQTPVLSTDIGSAIHTDQKTVYYICKRLTDPGLIVKIKARETGTTASYFIAARFQDSCDLLIQQRNAEITTDSHQSDIASGPMLPMLTDLASSSRLPTPQVDIPSNQPDVDAESDQEEAQPASGPIITVKDEESQAIQLADIQGQGNAHVPLQTLAPTFQHVDPGKARLWMSSRPELVRFRIYLLCNSTNSKITKRHGLVHRINIAYNLSLKRIFTNVLEHAIVDGFLEVVQLLIASTGRTSRGLRMTHKGLEEMQSMLQGDFDDPASLEEQQRARKLNAALQQDLDRFESRLPRELTLERWMYEEVARAGPSGRTAAQLMAKLNAAGHFSRVIDQIILRAEDADGEPSMNDLRIRTFHEHSLRIRSSKLFSNHAWVLQSANDGYLEQQDRDRLALAGGPSCFHQQSTAWDEPAQINQLVASFSQEIATPDKRLEPPRRGRPPKRRAEPDLNTPPKKRGRPRKNPVPVDTAEPSPLAADANNDAIASSCATPLPTEGIEQTPDLSDTPMERATSTLEVVEHSVEPADEFRPEPAVPDSPAAGAAKRRERRLVQEQSARRPTSLLATAPVVRPSTMHIDEAAEARPADTAEATQHEAERDSQMVAHEDHPNPTTSMSEGNLGNVADLLSNPTRPKIEAEWGSVATPASKSVFEAGSTPTTSDRKKRTNLTQLRSAHTLVQCIREAGGAMDALLIPEQLSSFVERHGFTSEAQLVNLRDKKVRDKAIAAAVNNDLLRRTYVRIDRPSAPHPRRQIIYLPDLPQQTLHAYCDAVKTERQGWFDTKASIRTLTNVIDSVEVGSMDALHVDKPWHQSEPMRLADLPADMAQLAPLRQPFRDVTSVHRQHLGFLSGEMLRLKAFHHACAHFLRLRASTPEIPGAVSGDGATLPLSFFWTDAPLDLYLGLVAVRQMSEPIEQMALDPNVRRLPMHALPLGLATALGLANGVPVEVKVALYSLASQLSKLGVLDIHPASHDAQEQLDTPSGDTVSFTVSVEPRARVARYNWLAEEAEKPLVEVLDVGLDADKINRFWARMQASCLSPNRSKALLANDDAQEGSEGLTAGTAVHDLRPGDIVDPFKTLPEELMFALKANKSWRPFHQLRPSQIKFFRRIDVHDCASASQEHIDRLAYATLVPQSVVRAVLEHRARSAQEPEDPDVAPHQSRPRFTWPLRLSTISLPTNVYKPIAAAASVKRKKTQAEREKQGRMTTLAKARQLRQRRDEQFQALLDQAFAEAPSAHALRPKIETALGVIRKKFVAGDVRFDADAAQKAIVRAIRSATGVRLMPAARAAPAARQRRRARQTSSDHEADAGEADNKATGGGVARRDRRGRRNVDQVNFWTPTRKELLRDAAVILRVRDEVRGRSDWTALLQVIEPEERTKTRSVIMAQWRSQYQRMRTLYGEEAYLAALESRWVPVYLAARQDGRLQDADFPSATNFDLVAQIELLRSSIDKNEVQRSLTKPTARHALPAVLTEASDFTASWKEDLVEEPVERRFEAFFSTEVGVTSRRLEKLLGTALGSEQADSPTQRDASIEELMAECAVRIVVATSSAETDVDAASGSTEHVVDEAIKADFCSSVGDARIEAAISRMLDAKLLRAVSSDPALRRRPGTNFVLGDEMQKLLADGSARFILGAGDLEASVTHRRWAWEELCAAEEGMYVQPVETDGEAAAMMVLMEMGAVEAHVETGAFEALRQNAAFNARVLNDEDLESLIHVRAGAGALRVLERAVLTLPPIPSDSVLDWLDSADLRTEWNAQCEEAPDVGACARTLMDAGPAGLVLPHLAYSAVSRLVAGSRPLAFFSPLSAQPVLVASVYVHAYTLHAPSRTLPHAWTTLHPTPHPTSTRLWRSLLEHCLALVRQRPGMSFSALARRFEPRTGAPAVSAADVWLAITALCDAQAVVAQHDLSLQVHPTRPLAAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVH4</accession>
    <name>W3VVH4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002317_1_0_1"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000071">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.3, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1252"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1611"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1721"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1349"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1815"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1349"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1375"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1447"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1460"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1517"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1564"/>
            <end position="1576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1847" mass="202411" checksum="D46B02B7CE245DF7" modified="2014-03-19" version="1">MSKLQRGTAAYRGFTVSHQRVVLDLGFNGTVVGFTELTIVPAHRSLRTIHLNCRQAFVQSVSIAGHAADFSYADHLTGASIADTRDVHRYPELKRRIYAAASDGAHGELSILIPPDVHIQSQRAGSRAQSIAPDDAPTPGGSSASNELAPITVRVDYYLKDPTDGIQFMRPTADSPYRVPHLFTIASSPDAARSWVPCVDSLWERCTWEFEFIVPKSLSTSEEDDDANPDQPANRSVKDSANTATAELADPDSEVVVVCTGDLMEQVTHPNNPAKTIFCYTQAVPTSIQHVAFAAGPFHIMRVQAANRQAGGQTAASIVTEVTTGAPLDDSGQPEILAFCLPGRQEELRNSIGFTRQALDFFSQEYGSYPFTAFRMVFVDEPPQDCTVQSMMAVCSNDLLHPATVIDQAIENRQILSHAIAFQWVGINIIQATWADTWLVNGLSLYINGLFLRRLMGNNEYRFRLKKDLDRLCAWDIGMPPLYEAGAFEPPDAATLPFVNLKAPLVLHILDRRLRKMGASVGLGRVIPKVFLQAMTGEMTNNMLSTQQFLRTCRKVSGADLRLFTEHWIRGSGCPRFICSANFNRKKLLIEMHIRQEVPAAQFAAARPGDALAANAVPLFEGQMTVRIHEADGTPYEHVLEIKGPAKRYEVPFNTKYKRVRRNTKRFQARQAAAAAAAQGDQEAQEAIGLIDLGFGLGMWEDEQAREEWKVADWTEEDEEKMSSAPYEWIRMDADFEWLASIHFEQPDHMWVSQLQRDRDVVAQVSAVHALAQMPSLVTCSMLTRTVLVNKYFYRVRTEAVHALVHCAIPQLDNLGLFHLLKLFRSQFCHDPPNEASFEDPLDVPCIPRANDFSDAADYFLQRALIHAISRVRNPDGRTPAQVKRFLINLLRYNDNSTNHFVDDFYLAGAINALASAFIPIDSGLAQDSSANADEENFLLAHAIAEVERLQELDRLVPSFHNVITLASLDFQVVMMLANLKPRDLQLFFTYTRQGNFTPVRVAALNCLLLVGNLDHRVIARYCFAVLRLDENRTVKRALARALCEGLAVAMSTGLFGGGALRGPETLLIEEDSGHINAAEKARDAQLEAMLKTLKKEIGRSAGVREGFLAALLAPNADVEARWAMLKLAELLFRPAEEKELPLQHKVQLRVRMPSSQATLDNAPMESPSISKIKLVRPGISSAEEDAAAKVPASPAAAASNGPRVAFETPEKVTAEKKKVKPKKIKPLAPGQASGMSFADLTACRNTLKKLMQNKHASIFLNPVDPVRDQATDYFDVIKEPMDLGSILNKLDSGQYKDRHALRADFELMIRNAKTYTPDPKAWAHKQAVGLEKVFGPLWNRMEKTLEQSAARQKAAQDAALANEQSASVSETPERPSPAKPEAPPAVSEAIAPTLPSSGARRESSTPSAAPKLSLKFKLKSKPAGEESPAAATPTPKPKAKPVIEEPSPAAPSTPSTTLKIKKPLIKLKKPSEGDAGVPSTPSPAPPVATNAGPQSVDDDILELLGEIPKPSKPKPSKSSSGVSPSPAPVAAASAHASPPAPSPSVKKHKSAHTDSFGGAATPPRTNGSSAASAESPTKDIAKLAEKDPVGATAGMPMSGKKCKVLLQVLKKSPFSIFFRFPVDPINDGLPTYLDEIKEPMDLSTMEKKVNQAAYSTMGEFAADMELIFANCRQFNPPGTEPCQHADELEKQWRKEWAKTVTPRLEANEKRALVGLMNRLKTHQSSLLFREPVDPVALGIPTYFDVIPRKDARDLSLIEAKLKGDKYDAFAALDADIKLMLKNCYTFNAMDPAIIEIAKAFETFYKREFNHAKQQAGTASAGSPAPPAAKRKLSTPSNGTSKKVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVQ9</accession>
    <name>W3VVQ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVQ9"/>
    <dbReference type="HOGENOM" id="CLU_101472_0_0_1"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26265" checksum="DAED2D13F904F676" modified="2014-03-19" version="1">MSRRSKNPTPVGHFSRTLAECILWGQGGGSLRWAAALRQKTAWIDRAAPRFLPGAPHSCALANSQLATHRRSMALNWVTLGQDGRSPLPLPDETVLCRVPKSSIQLEYASRGITYKAEGSALISSHRFVFVRDSRGAASESELKSLSVPIDHLAASKYTIPIFSAPYLQADVYSVAQGGLPERRPGEEAHPVGKLKLWFVEAGGVAFRDAIEKARHMWQQNRQQQLDQDALPAYEPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVV8</accession>
    <name>W3VVV8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVV8"/>
    <dbReference type="HOGENOM" id="CLU_083660_2_0_1"/>
    <dbReference type="OrthoDB" id="2339190at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833331" evidence="1">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="188" mass="20601" checksum="97A74E45BC7E4FDC" modified="2014-03-19" version="1">MQFSTLLLSASLLISSVVGAPMASFGGASEAEMMLKRQYEATQWDNIMLGRDTMVELEKRIVYNPHITSPTSNTVWTAGETVQVTWDASDLPQEAENYTGNIKLGFLPANGEGGYNLKWQLAQGFLIRDEEATITLPADLQSRNDYIVVVMGDSGNKSQKFTIKAKGQQSLKDVIDAKIDAAFEKAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWJ3</accession>
    <name>W3VWJ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWJ3"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_4_1"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="78"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="460" mass="49940" checksum="29EB40A3083C8AD4" modified="2014-03-19" version="1">MTTDLPPEVHFPLDKQMLPVPGSKQPGFSSIYKSAALAEYSTSCTVYETLLRAKDENLKSDVAGWRPWNPVTKDFEKHFEWYTHEEVEEERTAIGSGIGALARQGRLGDGVGQTEFTVGIWTLNRPEFMIIDYSNIAYSRRTVSLYETYDAASAQYIIDHAETRILFTTPNHVGVVLAAAQAGKLPLLKAIVILDSFRPSKQAVKAALVDPLRDTLAKEWAKTCGIEIFNWFEILDLGRNNIAAHIPPNVDSIHSFCYTSGTTGNPKAAIITAGMGGYVSTAMAFHKRGAYTLISYLPTAHIYARLCEIVAVRTGGRIGYFCGDTTRLLEDMAILKPQMFPSVPRVLNRIAALVQAQAAAPGLKGALLRKALAAKIANHDRDGTLTHALYDRLIFSKVQALLGGRVEYIVSGSAPIRGDVLKLLRVVLAGLAYVGSGGARSSYPCGGAAKCPYCDEPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWM6</accession>
    <name>W3VWM6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWM6"/>
    <dbReference type="HOGENOM" id="CLU_746224_0_0_1"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF29">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37029" checksum="E7D3364E8D0EB6AD" modified="2014-03-19" version="1">MTFALLKRAVVLGTVAAGLLVLSSGLTVQVAALPTYKMHRAHVVHARNLARSQHDQLEDQVHALEAALQHYVQYGDQQSLEIYLHGLDGNKNQGEQWKPQQQPEQPKKQDGQPKEQPKEQSQWPKPQQQAQQQQQQQQQAAQQPQQPAQPQGQQQDDCDEGAPAAEQPSMTHHEEHHSSDDSSEHSETHSEHHSEHHSSSDDTSLGAIDGYTPPSFSTSSSPSVKSLYTSAPFTGHATFYDTGMGACGIVNADSDPIVAVSRDVFEQYNPASGNPNHNSLCGRRIEISWNGKTTHAFAMDECPGCEPTSLDLSPTLFAKLDDKDKGVLPNIQWRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWM8</accession>
    <name>W3VWM8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWM8"/>
    <dbReference type="HOGENOM" id="CLU_009830_0_0_1"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="903" mass="94405" checksum="94A3EC6D52953928" modified="2014-03-19" version="1">MQHAAASDIGPGPDSRRRTSSTPQRPQHITYNDTFRREQQQANQMPPPFPGASYGAGVPQLNQMRSFSGQPMPAGQFGQVAPPLGHSASSSVSSAGGFHPYRRTQRGNSDIGATNVHNFPSAPAQPPSAVASGAAAPRARTSSAASQSSSRETSPMLAAERKRGFAAIPSSASSPSLGPSLANKNVSGAPSSQVGLAHLRGAPPRSNSQSSLASEASSRTATATAGAPSPVHQRTDSSASLHSINTSSQRAAQPSAASSKKPSPLSRQAAKDDDEEAVYGGSDDDRVDGGRSTPMPGYAPKASKKTGLSSKLRKALSFSNMNDIHDNSSYGASQPNTLRRPNGIPGRELGGLPNSSGDTNASTGSTRSTSPPRTPDNGAALPGSSAASITSRRGTRPPLSNNNDGKRSIFNRKFNSSTDNISISSTVSSASVMLRKVGNLGKLARRHSLMGLTNMFNKDKEGRDGLHGDAFGTMPVASDDSALNTKSKKATKSKKGIPASASITHATVELESARVADAGMTPAASYVRQHQLQMQAQAEAEARAARERQESEARAREAGENRQKMIEKEKERLKSKRGWRKKFGSSGGGSISSITSDAPTGLETTYAEPDAYHADGINGQAGADPIVSEAPPQISIAYGEEGGFDASFDSELLEPPHMPAAGGLGGDDSGDEFETDSLRHWAEGIERSRASAAQFKNPKGILKKTASTPDLSLSGGFDKPFAGRIRANSYDAPQSASASSATHGASPMTHLSGSTAGVERLDGIGAKTDSPVSSRPGSRSGDVPPRSASPGAMQHAGGGVLGHHSNSSMPTLSLMMDGAASADFMPQRSVTAPTQPKKKLSFADDLIFHSTWPATVYDRRGEQATCNRLTPLLAQRIKEELNTYKMEEMAVAPSSRIYTHFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD64</accession>
    <name>W3VD64_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD64"/>
    <dbReference type="HOGENOM" id="CLU_411718_0_0_1"/>
    <dbReference type="OrthoDB" id="2884925at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF4">
        <property type="entry name" value="F-BOX INVOLVED IN POLYQ PATHOGENESIS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="161"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="649" mass="71639" checksum="3B6FDA43418A1736" modified="2014-03-19" version="1">MPESRALSHASSRGDSTRAVHDLQARLAAAEKDVAVALRDQNYDQLIVVSTKALEEKSNVMDKKVIKSRKNLLWARSHAYQHRNLHELALRDAKKALKLDPHDPGSFLRTAVMLANAGHSSQAENCLDQACELAQGLDPPTKAEWLRKIQKQRRMLNQGKTSPIDVLPNEVLVQVAQHLDYGDLSAMGQTCRRWRQTLLSIPALWRSVIIKSERLSESKSKSWLQHVEMCTARANNTLESVTFIPPFPLALLDKVLDLLRGSAATLAHLALPVKNQETCYSRLYRYCPRLSSIDCTGCDASASSSDSGGATLPLGDPGSLVEPFSLQVFRTDPLNRYSSLVSHMHSLRVLDEFAPSLVLLRACLPNPATGDISDAYDFVVQLLQTNAATLEEINGPNMWPHPSMLRQWEEISITFPKMVKAALGLCTKLQFHLPNVLDLALDLRMCGFVYEPRLTALLETSPCLQTLKISATDTTAPNEITAALQRLADLQKLNLEFAGHARALVATLLPTAISSESGESGIDFRFSKLRQLTLDASRLDLTRLAAALIVRDSLLNGDTLQKAHQASNELLKALSHNTSARTASAFQRGAGTKALPLSNQEDRSPRLDNPHQHSRLVKLCLTGLRELPEDVESALRLTVPELELSYSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDJ7</accession>
    <name>W3VDJ7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDJ7"/>
    <dbReference type="HOGENOM" id="CLU_797394_0_0_1"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="351" mass="38628" checksum="89B08B08CE20E8F1" modified="2014-03-19" version="1">MVYSETKLEPPTRLRVFIVRHGETRENVERIIQGQLDTDLNERGRTQADTTGRFLATTRIDRIIASPLKRAADTARAILKHQSSGSLQLEFDDRLKERAFGVLEGKVYNGGAKKPEDTEGIERMEPFSERLASFWNDLVTRAAVPDSETAERTETVVLVSHGAAISALMNQVLTPGRYCLVPPSVVPSRFWNCSITELAVPVIRTSPASIASTSAGSASRRADWSIRPIHLGVQGAQFILDHEVQKKLLGTMRERALQDRAAQDTLRELEAHVAKTAAEFERDPQGKLQLAADVIRAPDGTAVQADIGHGPAIGTVVQWSNIDHLKHLDEPAANAEKTSKPNNINVDELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDK7</accession>
    <name>W3VDK7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G10 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDK7"/>
    <dbReference type="HOGENOM" id="CLU_087132_5_1_1"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13770" checksum="D2EDCB8847414B3F" modified="2014-03-19" version="1">MPRLRTSRSTPPPEGFEDIEQILDDYERKMRDAEADDSQNKRKVETLWPIIQINHTRSRYIYDLFYKREAISRELYDWLLKYQYADAKLSCVQAPSSNASIADAADAARPIDTPVNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDW1</accession>
    <name>W3VDW1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin modification-related protein EAF7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDW1"/>
    <dbReference type="HOGENOM" id="CLU_361766_0_0_1"/>
    <dbReference type="OrthoDB" id="2556553at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="81972" checksum="2E5A571665FC5A86" modified="2014-03-19" version="1">MTAQTSRASTSAAMLPEDDDVHIAFLRSVSLRRPVGPHKHFKMLSVVMDTQKALDFRYQRLAARLEKLSSAAPPSNASDKKSRPPLSSAGSNVSATPRIRRNLGHSRKGSRSRSGSVASSGPAEDDGERTEDDTEQNEEEERERQQETEQTRLAIAALGLDRTVKPEMVWNELHKLFDLEALDDMEEGAIFDSSSQAGAATDTGDSSSDSASSSSPPASKRKRSLTGANANKARQLSADVLSRCVFQHPGSPDFHADGERKSRPNAQSQNWIYGDDIRGTGDGMARRDFYLWPWEEYEPLIAKRRIAKDEEEEGTAAAKDEGSAASDASAYAKTPKRSASPADTQDASAKQEEDEAEEGGEGAEEDEDLSEPDSDAEVSKDSTPKRRSGRRGRTDAPEPKKKASRDTAEKSEEDESTPAAKAEPDADEEGESDEENESSEQVRTRRGSRKAPTPLQRPPRTAATGRKSTSGTVTPTRSTRRGRRAGNDGTEASEDEAASDAAESDTNEDGEDGKADEDEEETPSEAESAARRRSGKAQQAASSARKGSKKRGAPSSDEEEVDARPSVRRRSSRRASKSEGVPDEAEDEDMTDAKEEQSDAASEGGRESGSERNDGDGDSDAGDDDKEAASNQASEDEEGSDEEDDDDASDGDSAARRRGKGSAKAGERGGRRTAASSGGRSTRASVVSRSSAAKEPKESTPSTPSTPAKQTRSSRSSVTPAGSISRRGSSDKQQTSTPSARTPARATTRSSASTDTRSTRRTPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE50</accession>
    <name>W3VE50_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_06347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE50"/>
    <dbReference type="HOGENOM" id="CLU_075474_0_1_1"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="132"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="225" mass="25087" checksum="7803F5D88240B8DD" modified="2014-03-19" version="1">MSELFDSYASDLQQLKDGIRQKIDSAKSQNGEAKKSTLRRAEMELEEAEEVISQMDIEVQGFPQSVRSRFSVQIRGFKQEIQGLTKEVRAGLASSSSSSGGAAYNPAYADDDADLEAADSATANRQRLLQGTASLEDGTRRLEESNRLALETEDLGADILRDLRSQREQIENSRDTLRQADQSIDRSSKTLSKMIRRAKQQKLVTVGIIVCLVLLILLILYNKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEM4</accession>
    <name>W3VEM4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEM4"/>
    <dbReference type="HOGENOM" id="CLU_438131_0_0_1"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="140"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="624" mass="68082" checksum="7320B26063B9E7F6" modified="2014-03-19" version="1">MANERDSDRGSFRYAPRDAAWGPSYRPSPAAHTDSHPQAGAQHQYDAYAHERTRYAAHPQHQPVLPRYPQHRSAQRDEWARTSAPASAHDAARPSERHRSQHAAATPDHAHATPGFPSRSEWLVLPSVTQALGMYGDKRRQEPRFSLVIRQQPRRGLAVGNSQMSLRTARSIPIDPPPVCELLLDRSGDEQLLSLPEVFIRAQLVRGDSPKDECLPDARRIEPLVGDTLQSAFNSRIDTREDQSFFVFKELGVRNRGVYRLRFDLFDRVGARIFKIASVYSDAFEVHERRKHPGLSASSVLMDALVDRGMKYKLRKASDKHAKKRKSPEDFYYGDERFVSARRQSYAAGEYESRHLSSSRSPGSDASLQPLRPTPLRAYADKSGDGEMLPPIGATCAPPAYAPPHPHAYTSHSAPPMSSPVGLSPPVGAMGGPPPLPSLSRLAPQSRSYPAPQLQVPSHQPRWSHDDRAPHYRADGPRLSPLAVESDRQRPSLQLRSSSSSIATSSTHNSTPNSSTTDTPYCPSKDSDRPQLSALGLGIAKLDADAAAQANPGASVARFVAREAAPLPSSSSSSSSSSSSSATRPTLPPISSLYVPAPAPGSRRASAVHALSQLESPLSPPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF36</accession>
    <name>W3VF36_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF36"/>
    <dbReference type="HOGENOM" id="CLU_011269_1_0_1"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="648"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="930"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113807" checksum="BCE049B081136A16" modified="2014-03-19" version="1">MVASDILVPVTGLFVHSIVPSDHIHHYGRGILILVVDLIPFLHAPSTLETMAQNPRPGLRSQESLPDSFVQNGPASPPYQHQNPLDAMPPIYASQSNLAEHASHPDQHMIRDAALAALASGDANTSGSQAPSPDRKLPHHAAHDTGILESRTDSNPSSRPGTAGPRVAITDPLAEFRDRNLSKPAGLGPKSDFPPHETNRTPGAFNYQHNVAYRPPFVRQDSELSSENGDRDYGEFDWSDEDDLDEAARFENEQAKQVRMGRLSLWKILNFLATTFLGNLIISCCLLVPVIVIQYVYRRRGPDEGHRDFVADNVQAWFIWAAFNLHVEWWIHLLVELFPKAVLGVIQLIWGRPSQRVLSLAEYFNAIKGYLKFLCYAALSWGSWAIIFNSVYGLYNHTHPRQSRAAYLYRIYQIIEFFFFFTLTICAEKVIIKHIAMSFHKSAYADRIAKVTKSLKVFDWLRDHKPKLKGRETGSAFGIPMRSARGSPSVSGANTPMTPNDFVLDGDNTNSRNASSSSKGTWFKKHSKKRPSDMAAYAGENDRAIDPATGKPAEGQAPARGSGKSNIFARTAARSRRRIRATAGQASTLARVAMNDPFGLLRNEALGIGTDVNSPAEAKRLARSIFVAFRGSHKRSYLVPSDFDSAYTNPQDARDAFSVFDRDGNGDISQSEIKNTVMQVYKERRFLGRSMQDVNHAVGQLDGIFLVVALVIIMFEALAIFNVDIGKTLSTFYSLAIAFAFVFKESAANVFDSIIFIFITHPFDTGDRIQIGEAVLVVKRMSLLSCLFVDSLNQDVYISNVILAGTSIINMRRSGYQWEAITAQFDFNTPLDKLDAVEEDMIHWLQTEPERLFVPSTAIVPQKIEYMRAMECTIGMTHADTWQDWGRRFYRKNAFFAAFSFYCKKHGIRYANPVQPIVYWTEDAAALPPSYDTTSSAQRRGSQEGEDESNGYVLDDFTASPYASPQIRAAGGAVALPPKKPKSFMNFTPPLDELEVSDSANVRLRRVKRGDKMLTTQGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF87</accession>
    <name>W3VF87_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF87"/>
    <dbReference type="HOGENOM" id="CLU_2198076_0_0_1"/>
    <dbReference type="OrthoDB" id="3354362at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="112" mass="12945" checksum="09DDC96702D68723" modified="2014-03-19" version="1">MSLIYTSQRALRQPAGIVFLHPSERVPRSELDRRDRCYRAKREAEYARAWAEDATLVGTIIYNTDSNRISADRASLGAQSSVRRRRRSSNNVARRLSRKLRLNTLKNLFSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFC0</accession>
    <name>W3VFC0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFC0"/>
    <dbReference type="HOGENOM" id="CLU_2085802_0_0_1"/>
    <dbReference type="OrthoDB" id="10544159at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="117" mass="12577" checksum="6E3E55E442174372" modified="2014-03-19" version="1">MEASARLGLARLGSVRLGMAELEAAWLGGLARHTRADSVAAVRISARLLLATSQHGRSPDEQTHRVMRKRKRGQHAVAQVDEQVGVVGSFVSSPAENVGLTFLETPHVGPAWPAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFG3</accession>
    <name>W3VFG3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFG3"/>
    <dbReference type="HOGENOM" id="CLU_077738_1_0_1"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25126" checksum="36D03619BB93B9C7" modified="2014-03-19" version="1">MVHADAAALPSYVQSKADFYDHLESSLLGLVDASTDWVSSLSNAASLIYASMNRFHAWEAKRINWAGFYLLSPLMPSELAARRPRKQPTLLLGPFNGLPACQLIHSVPGRGVCADASALLPPRVVRVDDTEAYPGHIACDSLSRSEIVVPLVIPRSRLAAPHRQALEQQSPMNNAHPQTADDKSWAGRGNDENVIIGVLDIDCESLNGFDAEDEARLNKIAHLLVERSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFH5</accession>
    <name>W3VFH5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFH5"/>
    <dbReference type="HOGENOM" id="CLU_030880_3_1_1"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000178">
        <property type="entry name" value="Predicted phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="389" mass="43095" checksum="27BAA5A77F8F802F" modified="2014-03-19" version="1">MLRLSLRGALRSVPSRTSAAAARQSVRSLSNSSPTRTSTNDLQKPLAFAFDIDGVLKAGPNVLPEAKRALQILEGNNPRNQKIPYIFITNGGGKHESARATDLARELEVPVTPEQVIQAHTVMKSLVPLYADKPILMVGGPETPPNAARDVMRSYGFNNVYTTLDLHAHAPAAWPFSTVHPDQLPYIRRDAFSKVQFAAILVFHDSREWGRDTQIIIDILRSHNGVFGTEHPPSEPLPEKQIPIYFSHSDLLWGNDHSVVRFGQGAFRLAIENVYKHTTGREMESTVFGKPYRITYDYANELLRQHLISMAPASSATAEAAKLVGPSVWMVGDNTESDIRGAVDYGWSSALVRTGVYKDHNGPPNYTPTILVDNVEQAVIQAIQREWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFR1</accession>
    <name>W3VFR1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFR1"/>
    <dbReference type="HOGENOM" id="CLU_809239_0_0_1"/>
    <dbReference type="OrthoDB" id="10498588at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832936" evidence="3">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="343" mass="36203" checksum="9762C4E3E03BA315" modified="2014-03-19" version="1">MSIWARRATWLAVLMVWLLVTASAAPLSSSASTTTSWTSIESATSTSLTSSTPSSSPSIESTSSTSLQTSSTSTSSSSSAPASSAVSTSSSTSISSLSSTASVVRMASSTELASTTVSRSQESRSTPLRSKATPVHATTSHKSSTHREHPTSVRASRSTKPKPTRSVRTRSAKPTRSKTSKPSRTVAPKTRTATPKTRTSKPSTTHVSASQTHTTHLHSSKTHTHFASPTAFHPKGGNIVADPVPGSTWEKVRKILLIPLCIVTVLTFIAGVGLYVAATWGSGEGWFEKRLAAANLDEKGQTIGPGQPDVFPQEKFATSNKERESGQFQFKAPSVHDQPPPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG24</accession>
    <name>W3VG24_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG24"/>
    <dbReference type="HOGENOM" id="CLU_012288_0_0_1"/>
    <dbReference type="OrthoDB" id="2556336at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="689" mass="73102" checksum="FB0F2A22D2442FD8" modified="2014-03-19" version="1">MQSSCMHICHCGDTAAQQAAPAPASNARQGEWIWSTSDGFAANTCDLEYAFAADSDNFLGLSAYSTPTTSTLAGTRAKPDGAGSATTWLPQNETVDGLWGASAFVDMDLLPAGMAIDLDLSIPSLAQLGAHDVTATPNSRHDSLPTPGLTHSPASARTYEALPAVGFSAHTASSVGSAPSVPATPTNPSLIETDSLAEQNKQTAYQEMLAAPAHGLASAFDFTNSPQTTTTTQAYAHQHASIATQASQARACVCSASLTRTATSTSHMDMAAQVAIPAPGWLNPESVSVLAPVEPYASTLAPPPSVLEYSEWSDAGTGGWMMPATCPINTRYEPYRTPSVASTASSSSQSFLAEPSGSRRRSLTVGSLPSAASCVVDRVRMIGACRAPSPGVQRSLPASPRLSASKKFNSMPCRRIRAPAAATSTFPPEVVESASLVDRRMASLSARSRSNTPHRGLASLFTACDAFIEPAEASPALLDLSLGLNTPTSSTFSRPCTPTLASIGAKQDGEGEEGRAKIAMHHHRTKLQRAVLNEVVTSLQSAYKHCRRQHALDSASELAGELLALQLQDHDGWQDGSSSASVVVAGETREMRKNRQKAESKMRMRRKEIQQFAALVRFAQLAASPTTPEPVVRSLLEVLAEHRESWCTLMALEKRLFHAVRDKLGLTELVVKKLLEQWTPPPTTDGMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG51</accession>
    <name>W3VG51_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG51"/>
    <dbReference type="HOGENOM" id="CLU_694689_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="397" mass="43793" checksum="E1D36974A747B5BE" modified="2014-03-19" version="1">MSKTQTNREAHKRGVRTPSRRKTKQSVESDNPAVVDLFAAISSRRTRGSHVLRQAASASWDPKHSGRKYPSDGLDPWPRPLPGVELPPTHELSVISHREAVNSSVGCFPQIRVASRKKLQQVQRLQLQQLFAGPLASDVPNHASLDARYCARQAQTFPLQSRVDHGYSPFLGELLAPQPDTPAWPSKPASQTPRRRRLLFPDRSRRAAAHVRGSSPLELVLRQQALHTQHCNCFVLRSRSSSLRSRTLPVGPASYFPGPHHFAPSERYTAISISASPPSRNRCHLLGLTASCSLAAHHLRLYLLHVKLCCPSPSNLAIFPTSSPPILALPASHCPSNPRSSIRTIVGASPNKLRPPQFSSDAIICIPDRHCFRADLSRADPRGLHRSRDGQGDPGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGF6</accession>
    <name>W3VGF6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGF6"/>
    <dbReference type="HOGENOM" id="CLU_374359_0_0_1"/>
    <dbReference type="OrthoDB" id="2556531at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833137" evidence="2">
        <location>
            <begin position="27"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="679" mass="66802" checksum="80A955D039ABE05B" modified="2014-03-19" version="1">MVATTKFASLVGSVTLALIVASSLNAAPVLVKRDDAAAPAGYISVAQPQMNEQDIYAVGIPDAPAAAPAAGATFAEVIQAAAQAALAKSNQTMNAVNTYDPTPAPAGAAQSQVAPESNVAAAPNADAVLAGNPDQGQAFQQVIGNLAGAAQVAEGDAGLKGNPDEGDEYRQVIAQQMAQLGQKARRALRNAVWEARQIPPPLASAGAPSTAAPSTASVTDAVTDVPDTVTGVTDTATSVTDATTGATDAATGATGTTAVTDAAGDVPVAAPVPSDYASPPAPSPSSNAAVPGVPAPAVPGVPSASSVPAAPAVPTSGLPTSGVPSVPTSGVPSVPTSGLPTSALPTGALPTGAVPSAPAVPSASVPALPGLGGGLKDSDAGATTVNPSSPSASPTGDLTMTVTLPSTAMPTSLGDLANIKANANANADAINEWKTMTILVPAEAFGGSPSRAASVPAATSTASASSASASSTAASSSSSADDAKVTSTASAIVAVPTDPINLSSFSALKPQATGVLTIPLTGIIDGTTYSTMLTLTIPGVATETAKIPVTTASDKAPATATAKPSITAAPSKTSSAAESVKTTSSVDPSYIHPDDIPPLLKSSMQATPTSTPNPSSNPTPDGDDEDCEDVDDNDDTDIAQPKSLLTKVWDWMSGKPLDERDFEDDYQDAAFEEYYDAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGQ1</accession>
    <name>W3VGQ1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGQ1"/>
    <dbReference type="HOGENOM" id="CLU_101084_0_0_1"/>
    <dbReference type="OrthoDB" id="3356019at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="240" mass="26058" checksum="9B6B06AE98314B6A" modified="2014-03-19" version="1">MSALSGAANPEYASTPSLLTQQPHQPCMRLGQASDPTVALEQHPPTSFSRFGALGSCCVSITMSGQPSTSGAQAAANEPPLSALSTSTLGSAPKRVRHREEQIESAYELQRNAAMKGALLYTALGASTCFMAHHLFPGFRRQTLALKGFLTSGATIFGFVVGADTVLLSHESQQRSEENMVRSRARAELGKKGIVASEKEIEKWKDEYIQLKLEERRKRREQLLRDMEQSDRAAASPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH85</accession>
    <name>W3VH85_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH85"/>
    <dbReference type="HOGENOM" id="CLU_425851_0_0_1"/>
    <dbReference type="OrthoDB" id="2556492at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833154" evidence="2">
        <location>
            <begin position="26"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="643" mass="67026" checksum="622CFB36B48AC2BA" modified="2014-03-19" version="1">MGAFAMPALGVLEVVVVGATLEVDAEEDEVADDVADEVGEEEDVAEDVEEEVDEVAVFTELMENEMSVPSVAAASVVRDEEVAVVEEAEVEREAVVLAEVEGDEEDWAETSASSSAMHSSVDERAEVRTMAEMDAQQSGAERSANSKKDGAAQITGALLLARLRCLALRCARTAVQKLPLFLDHPRTDGWLAFLSPSISIRSVGLGAKPSRSASTLVPTRHARLHLHPPSTSRPAKTHTRPRSHARAHTPSPASLRARAASSFLSSRFRLSYTLVPAVMDSAKIFALGLAAGLAIHVFVRNGARKGAKHAQQAAAPPSPSIASKPAKKNKNKKNKNKDSPTPPSTEAVAAPAAHAPAPAPEPVAKPVESAPAATTSKKNKKNKKQHPQPNAQATTPAESYAEVAAADDAAPAKEAVSNDAISNDAVRARSDAAQAALVASLGDMRDADVDELPAGYSSVARIPASEPAATHRISRKDQDDGWSSVGGTFPSSSRASASSAKPNGTATHTSFASTNPFAALPDDAPTASVKRLPSKPSAPSGGGWTVAAPGPVKTRANGAASVVGAGGETKKQRSNANKAAAKKAAKEDAERLQAERLANHRRQQALEAAQQRDAARRPAPHSVSAKTPTAKASVDLNGRLVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHD3</accession>
    <name>W3VHD3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dedicator of cytokinesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000595_3_0_1"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="7">
        <location>
            <begin position="668"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="8">
        <location>
            <begin position="1622"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="769"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2042"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2190"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2190"/>
            <end position="2218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2240" mass="248099" checksum="0F18512F1DF0F0D4" modified="2014-03-19" version="1">MAASVSSYRRWEPLPKILYGLATHPFSPDTDVLESSAGPLESLPPDVVHKLHENLIALELGDEVYVFEQLGHADVSWYRGYVVSTNRLPVAAASASSLSDYSTFHALGSNPATPVTEEPQVYVGVFPSTHIHIREQLDDAEMRLASVYEHAKELGIVGATAPLPRPRTHMETLPELDESTSQPSSPNQYPTSHLPSIDAATQEVAANGQIVDHPPPPLPSLKCGDETLSGAHDPLIDEIACALREWSALTYNYLVQRDYTLLNSVKEHIEILYKARKQLLANTLSAEEVSKLRRECVARLVKGNVAQGLDVIVRHPNRGGLVDFDINSKDADPDSWVSGIRLFALQAALAYVDHESDSSSTTAPGGMDLSASNAFGISSPSTGNIGALAGLPGDVTRMPGIGARQASVASIKRVEDASAAAKYFHVFIDLRAFVATPCSAGEVVELYFSLYNRAESRFLTEDFCIILNHRGVPTKDSTGRIDKMRAVFTELSASDMQDLNVVCRIVRNGGMRVSEIKATPSGAAGQDLPHDRVDSFADPTLANTPSFRPKRMAGDHSFRRPFGCAVLELGQHHHFQTDVANSSSMREHVMPIFVPVNEAAFSTLHQDIIASRTREFEKSPRADMLAVNVKVFYGDTASIIRENPSLLQDTPPAARLGFPDVVFPGDTRNEAYVKLWSGEFYPSGNKMAGGSLRNIQVSAEVRTRDGRVVEDVVSRGAGEALVTQFDSLVFYHQNAPTWGELIKLQLPHDIMEDCHLFFSFRHRSSKEERGALSASNGVSASQQATSTPSSSSVSMSKPFAHGYLPLFESNRAFIPDGSHTLFLWRTNRPPAQIGPDLYFNLPPVTPAGRNPGDVVPPSLQGTVQPLRDILTLRTFLVSTKYSQNDVLLKLLNWERLLSEDFEELRSVLNKFTFVGEVEIVKFLRDIFDSLFGIATSSRNTHGDLDDLVFNGLVTVLGIVQDRRFNNFRATLDVYIEQHFKFTTAHNKLIASMAKLMAEPSRPETSKDLRAAIKVWPYLFKFIIQSRENQRGDRDVGGGAVLDHLEAGFKRELEGLLRSINQLMSATTPSSIIGTQTLALQHFAGILPDLARVFTADELVRTATAFADSIFITKGKMAIWKLLHILQLTQGPLFDEQASRSQMIPSIVRWIGPHLGAYDEAAHAPSKALENARDAARVSWIEAARLAITILAVILDRLQVSLAAGPSPASNGAPRARGRQEQDDVDYLLSMMPKLLDTYRELSSRATIRALERHRAPSTTPSPVPVIFPSSYPFPLVAKRPQGHASVVDGPSSRRNRRRDRTEFLNCGLVEIAAVLMVLIVLSPRKHLLSFLDEERDIGGEERTAKLLLDFFEVATSILSYEAFPSTWLNLNIFSHQMVMKMADPLASVMVRHYIPSAEQSETFNTALWRSCLTMLLTLLSSDQLVIEQFKPQRRRAVWRLAGDIRGEGAQIFAKLWTSIGWPEAAADDADGEQIDRTDERMNTGGFQVQFVPSLVEPVLELCLSHHDELRTCAVRVLATMITSEWHLNGDFSVIEAEIIDKLDVLFMTHTKGDEISRAFFVGQLRALFDNPNVDPGLRDQVEACLVSVNRFLDLLLSVRSLPLEEGYEDDRIAGTLKLLGFLRQADRVSAFSTHVLRLVNLHLENQNYVEAALTLKLHADLHSWDMDNFVEPFGELDLPRQSHFARKETLYMLILDYLGKGQAWEISVDICRELAQQYEFRSVNYVRLGEVLHHQAKLYQRIATEERAFPSYFRVAYYGQEWPPSLQDKMFVYRGQDWEKFGAFCDRLHAKHPQATLIKSAAVPDEEVRLAEGRFLQVTAVQPEPDRTKEIFTNPEVPPNVRTYHEKCGTDLFSFERPLGKADAGQAEQWVEKTYLRCEDAFPTVLRRSEIAEVYVVEISPLEKALEDVTAKTSELETLEKKYLSIRKVSTGKINTNRLSMALNGAVDAPTEGGIPLYKSTFFAPEYAAAHADQQAAIDELRQAIDAQVTVLFRCIRLHAQLCPPEMKSFHETLERFFVQNFGEEIAQLDLDIRKLGEAPANSFDRQVGTGDEDGEENERRPTERTLSRGFTLGMGAMDRAGAANGFAAAPDGRQDLQPNAQYGKRGAAAQSPLQRHIAFLTRQAEAPANVDPAPAAVVAQRKLTADSSYVAAAAGGYGETSAASNKVLPPISEDMLGGVANMPSAPLPTNFSKHSLSRADSSYSIPDTASKQATPQKQGPGHRLSKFMGGVGRRKAFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHE4</accession>
    <name>W3VHE4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04872</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHE4"/>
    <dbReference type="HOGENOM" id="CLU_832079_0_0_1"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000002">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="157"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="339" mass="36113" checksum="A37C170AA2DD1FE8" modified="2014-03-19" version="1">MKTSQIVLTSLSVLGVAGIGYAVYFDHRRRTDATFRKNLRKESKRTSKAEKKAAAKRTQQEDGFIEELLQEVRAPGAFPSGVEEREQYFLKYVSLGEQLFAMGTDKYLDAAAAFFKALKVYPQPVELIMIYQKAVPKEVFDTIMRIVSKEIATGGAAEGMSAENLDEVDDDGPSQLEASKDEDDEDDDEEAEAKVDAAATEDKDASAGAASATPAAASAPRQGTDSGTTSSQEWDTLSATSLNETGVMVTPNAPASAASESPDTKEAAPKPSADELKPPSIDTSASVTQSSTQQPTTPSKQNFTSGWSPAPVFGASSPRAEKKASVEAGSDDETQDKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHU7</accession>
    <name>W3VHU7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHU7"/>
    <dbReference type="HOGENOM" id="CLU_289038_0_0_1"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="877"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="877"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="751"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1062" mass="117531" checksum="AC1603F989ABC9C4" modified="2014-03-19" version="1">MTRGEPIVISDSDSDTLSESERPRVQETSQTKSKAASTSRPPAPQLAKEPPAAEEPTASTSHEALSESGPYTNAATSATGLLSLLPDRRQLELERKERARKRKQQQNLPSTSSDEEEAETSAKRTKQIETHADSRAKPALWSEEARATNEAQPTPQPMGIRTAPATPSSSGSKFSRATDPIKPQSRFWRGTIKHGFNAYADKAASGVTISQMLLPATASSRHGLQLAVLATYDLRMDWLYSLFPKGLPVTLILPPPKEDYRTDPSVARPGLHRSEIFGDFARCPGWQICVPSKPKGGWLTQHMKFLILVHPDFLRVAILSGNLNGIDWERIENTAYIQDFPLNTDTAKAATPAHGSSQGRTNDFKAQLVRILRSLGMPSSHPVYAALDRHDFSQATRARIVASWPEASNLAEWDRMETQGLGRLGKVVRDLGIQPKRSGSLQLECQGSSLANHDIKWIEHFHLLASGFNPRGLLPFKGKTNDPHPEYFKAAGSKSGSLPPIKICFPSQRYVEETTVEGPLGAMSFFGKAETFAASPIKKLYFSPQSRRGDVMIHAKSILALTTKGAELVNKAFHDASEAQLTRGTNALVELPENTSWSPNEEERPIGWTYMGSSNFTRAANGNISGTAAKPTMSTLNWELGVVLPIYASEVERFGVEAESLRPIVYHRPLQQYSSSDTPWDNFAKVAVRFWFDSNTLQKQSISRSSTNTALPSMPPKGKDKGGGGSKTAVDKTFGMKNKKGGKAQKAVAQIQQQQKMAGKTKEQLAKEKKKEDDKKAAAKAAKELAADPLFAIVQPKVPFGVDPKTVTCAFWKAGRCDKGTKCKYGHSNDAGRKTEKKDLYVDMRDENEDKKNDTMDKWDDAKLNDVIMSKHGNPRATTDKVCKFFLQAVEDGKYGWFWECPNGGEKCMYRHRLPPGFVLKSQKKELEALEKANEISLEDFLETERHKLGSNLTPVTAESFAKWKKERMDKKTAEQEMLKKKKEAQAAANKMAGLSGREMFSLNPDMFVDDDDDDDDGEFDLNQYITKDWEQGRQDDDAQQGISEDEDDAGTAANGIRNMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIB6</accession>
    <name>W3VIB6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000322_0_0_1"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2790" mass="295439" checksum="1C60564F39A132A2" modified="2014-03-19" version="1">MGTCGQSSTSPGVAATPANHRFAPRHLLHAWRDLRCLEPTRASLRDPNVTEIHPVAAVAPPRFVLCSPSPDAPAQPCPALPWLCLGPPSASARRPVCTPDRPLAAAAAVPLWTGELLLASPGRRRRRRRRHHCHPLLTSSPSPTHPFAVVGTLSGPYSPPSDVADTDRHSTSTSTPVRGFNIDSSVSARTPRLARSLSTPSGCPSPYNIDLSSGAESPILIMADDGYGSRENLRRRSAAQSVDSDNAQGAGYYQPGQPIGFVRARGTPYEKKYFSRKLGYCCLFVAPGVLLVTLAITLLPVLYAVANHALHTAVLHVEQSNITNPGNTSFPLTLQGQTKKVGIFPAHLYFREPVQVYWVLPPQPGQVASPETLTEINLGQFRLDYIGAAAGHARIKQATNFEINDVEGFGEFAKFLISQPEFTWKLNCSSVHAEAFSFLPTYKNLVFNKHIIIKGFNNFEDVQILDFQLPGNDPAGGVSLSVTTSLVNPSPFGVQLGTLDLGLYYQGMYLGPASTTNLNVTTGRNVITLNGRLVPHNDNATELDLLGKLFTGYINGQTLPTQARGVSVRQANGDNIGWLSSGISALELAVPLKAPQPINPIKSISIGSLALVYTSETAYNPTAFSSALSAVLGLPFGFSLSIVNTANTFTILFDGAQVATINSAYSNTTTELSIVSAGQTAGTLNLTLPPSELTLANNTAAARKELENFQTYLTLSNGTAIRLQGEAKAITDTPLGRVLLDGIIFDVDSGLLGLQGLNAYPTLITSVDVTGGTNDGILLSVGTTLVNPSNLNLTIGDSNFQLVNQVVLGTVTIPGLNLMAGRNDVNATSVFNPNADPRGLDTLNRFIAGLDTELGINGFDGSTAVSSLLPALSQIRLKATLPGLKTSLVRSANLTVLDSTGITNNIASSTVFLNNPFTAPLTITRIRSNVTSHGIFVASIDTPLNFNAQGRAVTQSPPIDLGLNLYPPDIFALVRALAIQSGQNPAYIDGVVQLGGYTLTPTTSANSRRSLGADDATYDYEEDNELAHAMMDGVNNVETLANVAEWAERDEPEALEEAGTLKKRANLYTGFDLPTYISRAFNSATANLEIVSDARIGDYETTLTFAQQNVPLGTDVTLNKLLPVLASPIVQKIVDNAILNIDRVTILNPQQNTFQTALQGTITNSGPFDATIYFANGLDVTWNGRLLGRIAMPNVSLAGDVGATLEIIADFAVADVGYLTEFTRYLLTEQSFVWNIAGNGLQVAALGIEVGSISISKNVILSAFNGLRNSVIINSFDLPSNDPAGGIHLTAATTIYNPSQVGVQLSRFGVNLDRNSTYIGPSAAQDTFVLQALAVTTLPLVGRLVPQSSDQGLAVLSEIFTRFVANQNTDVMVLGDYAGPESVTWLNDGIKSLAVRVSLPSQQFTVIRTISINQISLFFTQQTAYNPPSSSNNTQSEFFLPFNFPVDIQQVGGGFIAGYQGQDMAVLDIPLSPSITDVTARILTLMFSNVPFAVYNNQHPRFSQFLADTTASNQVTFNLNGRANTKASTAAGVVTISNIPFNVDTNLLGLQNLNARPAVVSNLDVFHGYPSYLQINVDTTLFNPSDITIGTGDVTFQVYFLNRLIGTAVINGLVLVPGTNIVPTQVRYSPQGAENTRAGQTLLENYVQGIVSNVIIQGTRDTTPIDSLKQALSGIRLNADIPPLRQLLITVARLVIPPNIAQTGIAQANFDLRNPFTASINLLKVKADASYQGIFLGEINQDLSSNPIRAPGHTTITSRFLPFNFDLDPKNLIRFVQAAAATTGTDLGPLPPLFAQVLEQASTQTTISPYPDFNPPNCRSGQQFDVLGAVLRTLQGLTTTLNVQSSDKLDDYFTNLNFVQQPVPTQTDRTALYLLGPAGAPIVQNIVDQAVLTVAIANITSVTNTGFDVSLSGSLTGTGPFDAQIEFTEPLTVTWQGRNIAKLSLPPICAFANVGVPNLVTSGHLTITNLGAFTDFAIYILANPGFQWTVSSNRLTVRALEIIYSNVIISKNIDFRAFNGLPGVTTFNFDVYGETSNALLIRTGASIPNPATLGIQLDTANFEIFFMGTDIGPVSSANLFLAALATTNTTLQGQITAKSGRDLQNTGILFTNFLQGRTQILQVKGVSVVTQANGNQPVNWLSAAFRTLTLNVALPGQIYQIIFSITLSDLTVFVNGNPADSYVIPSSSNSTIATFANPFMFSLQPIQASPHINLSYAGGDTAYLDLPLANVQAGTSRGPQDFQALQLMWRRQNIVAVDRPNFQAFFAQLTDTPRGQFDLRGGTDVVAKTVIGNIPIGGIPFNVTTTLAGINSFNGVATLSDVSVSSGTPAFLWVPLKVALTNPSNLTVFTNEVFLPVIFSGTFVGRAEIPVLGLIPGDNLVQSYFYYAPVNANDTTAQRLLQQYVQPDEANGGKQISQLTIDGSQSPVGQGNLTPYDSLRPALAGVKLTTQLEGIASRIVTHINVYLTAQTLLTGLAGLLNPAASPPIVEIDVTAVNALDTNLYLVALQTSAKRTGETPRDATNPDARVSYTFPNGGFEIPVGGAEVTSPRVPNVVLPKGLIASLPVIGQNLDIYNNLPVRIGPSVGDSYLVPGLNYNEFNIPTDYALSLGGVNIPLGPVEDILGLLGQIAAAGVDLTQILGGTLTQLAQGNVIGGLSTATQGVLCEITKLTPGLGLSILNPILNQAKCPNAPGSSSSAVSASSTANPVASLADGASSVVSSVTEAAAGAVSTLTSAGGGVVSALTQALGGGSASPAAATASSSSSGGGGLLGLGTLIRRAEPTASPHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VID5</accession>
    <name>W3VID5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VID5"/>
    <dbReference type="HOGENOM" id="CLU_304866_0_0_1"/>
    <dbReference type="OrthoDB" id="2556057at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="989" mass="104098" checksum="F6ACC28C0C130132" modified="2014-03-19" version="1">MAAGKFHIEPPDSGYSAPQNLRSLTLSSSHQFQPGPPPGLGIAAPPAAALPPNPFGANGSSQQSHRSPLHHHSDLETPVKYERPSNCPRTYSRGALLAFSTSTLVVKPSSMGSLREWFGEWEAYHPKSSYNYRETSRRAHAEDAAAAHAAAAAHAVESEEGANNGGIIGGALGGFAPRREGAGARFGGRRNEDRERSEGLRLGEVGGRRVAPAGKNPFGQISASGTFKPAGTPGGGRGLPRDANPDAMGDARRGMGERSTSYGKERMRELLPDDRRRDPARDRRRGDRGLDADDGREEGEIVDSPRTRRTGGADTASDWRRPGDRDRAGPFSSLPSDRLRPGERRGAQRAGGAPWTGDADDNPAWLEDDSEPLPVDNRAPFGQFGSRRKDADDPLSPADGMGGAVDSIQAFKAQMKERERRERLARGEPEPVERAPLESHNESLGAERHSSHEYPFGSDAASQQSELDAIRAEMMAAANQRSASGNSMFDSISNSHGGPAAEGQAPPGLPGRSSRFARFFDGRGAPPRDPQAAALAAQQKMLESMGAQPAPPASEDKESSNVHSPKTPQNASSSSINISELFSKSSIRDTADATGKDASGKNVSDADQQSMQKLMAMLQGGGGAASGTGTPTSNKEHANEHAHHHQRADADDRLKELLGGGGQARHADHLGDRPRSIVSPGLSSAEPHGHAMEARSPLPYPQQQQQQHQRESSTSSGGVGHGQHLGPQHQHQHQQPHESQQQFPQYQQQLQQQQRSDSPAMGGGNAYNDPRQQLSSVGSPTSPGAPGVGSPGAAPGMGGFGGFPGAMAGRPPPPGMDPRMMARPPMGAPGFQQLPPHLAASLGLARGPMPPGMGSMPPPPPMGVPGPRGPNGGFPGFAPFPGGRPPPPGMPPQLYQQLMSMPPHIQQQVLAGQGFPPGMPPPPGSPYDPSAPERRSQSPAQFPYYAQGPGGMQPPASPQQHQPVAVGAHAINGANLMALLSGGRNTPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIJ1</accession>
    <name>W3VIJ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIJ1"/>
    <dbReference type="HOGENOM" id="CLU_079283_1_1_1"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="50"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="205" mass="21806" checksum="26DE425ED8A733F9" modified="2014-03-19" version="1">MLRNALAPLARQAAVSTSRSAAFSSVARPAVANFARSQSAFGAPVQRRGYHEKVIDHYENPRNVGSFLKTEKNVGIGLVGAPACGDVMKLSIKVNEDGIIEDVRFKTFGCGSAIASSSYMTERVKGLSLEEAGKIKNTEIAQELCLPPVKLHCSMLAEDAIKSAIKNYRSKREATGNKKQGHIEVTQDVATGSTTATAHIGSGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJB5</accession>
    <name>W3VJB5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="5" type="ORF">PaG_04750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJB5"/>
    <dbReference type="HOGENOM" id="CLU_415729_0_0_1"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="671" mass="71233" checksum="08B51F6EFE40002B" modified="2014-03-19" version="1">MPCPQPDDPAPQAAATAPEPARATVCVRCKANPAVAIFRDSIYCQSCGLAVFDQKAKSGLEFARGAGLAKYVAAEKAMAAAKHPSPDEPSASSDAPEQQATRSSKAIINGAGNAEVNVSANIAIALSGGPSSRALLRTATQYFRPESSSAARRSKGRGAKNDGQDAASASASAESGRRKNVNANGNANGRFNEIGKIFVFYIDVSAVVPGDAQDRTESMRSIVEQEGCPDLHFVPLKIEDIYRQSDSEGSAEGIPWKTLDSDAQLLSRASAPVSDPRQAIKALFSALHPSTLPRTAASSARTRLEDLHRVLIQSLLRRAARQYDCAALLLGDSATRISIRLIEDLAKGAGHKLAVQGSDAAWIDDTLVVRPLKSHLMQEVLFYTSALGLESLETEQHIVPPLVSTADILANRDANVPTMDKSSIARLTETFILNLEKGVPSTVSTIGKTGSKLVLNPTSERAGAEGPAHSTSAFQHVGPSVSLRSRDATGKMSALTLNEAPEPRIGSRGIKLAQASAGCFRWTTQAGCALCGMPSQQGARHWKRNITISSLAETAPTQPQEGTQDAEWIELSDHLCYACLLVLAIPTSNIAVEELPLLPAYVLEHIIRSQDATNAGVHAPEHEHEVLHSAKSSQDPALNGHNAHCASTTPLQPLNRAEIKAQINDFLLPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJC7</accession>
    <name>W3VJC7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJC7"/>
    <dbReference type="HOGENOM" id="CLU_364834_0_0_1"/>
    <dbReference type="OrthoDB" id="2552656at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="770" mass="83721" checksum="BEFBDCB810CD261C" modified="2014-03-19" version="1">MYGSPDDGSVISRPDTPSHSETISDSDVVRDAKHVHWHPLTVIPDAAGSLRSSVDQDAFAAQPNKRFRGVRARIKAVARFLSNSKEQDQSATAQPPSDTSDSVDTAQTSTTHVVNELPAEHQARSPRMKASEVTAEANQRDAVAVLEAIRERLDPEGSTTSTLHPLPPLPQLPQPPTPVLVPPVAMSPKKRHTNGFEDALGKGRPDFAHMQASVSRPAVPPPIRSVSRPLPPTPVHAPIPRFGKVDSLHSKPLPASTFSLGVFQDKKRVDQFARAAAEIPTHGDSTNADKPRAYRVNHQVDAHRLADELESLISSSARRRKPRSDFSSDTTRLADSSREAQCGWRPDASPGFPRHETFGQVHAHASSAATSMFANESEPEAIKRIQTWRVQITNPPSVLGSQCASAHSGLYTDGGLSSHLTSISRSPLSKDNKPRSQVDDAQKTPVLKSRALPNGRHRLAEESRRNKEGRSHRELRGRDAKTNTDGCHGIGTRHIARLTDSQFERLARATEALRTQGCMSPEASSIPDDVPEADKPTPQLGIGAEDGERRSSVDAARTTLSVLEARATPHIETLDAMIRRHPDKMYKLFQKRPGLMLVFLLRCKIEDRLSQVPSLANAEPVSKAEATEKDIDLLEGSLIDLHFDADPVQPSAPKQGREVSAVPSIVISHATGSTPTSTDATPQATQSPHASQSPEVRAGSDKTLHEIVCRLEKAGELCTMQHALVSIQNRLINTTDTCTQLSDRLSKLEQVVFSPPSVSHTPSTSFSMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJE2</accession>
    <name>W3VJE2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJE2"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_1_1"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="48"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="327" mass="36566" checksum="4F31953B0726951C" modified="2014-03-19" version="1">MASFTDPFDAAGFSSQVVRIPPPETDPDVDVSIFYRRSPSSDKAKRGILLLHGHPQTHVIWADIAPALAAEGSWDVVVPDNRGNGNNDGPAPKSAPGYSRYSKREMARDMVELMRQLGHDEFFVVAHDRGARIAHRMALDAPDKIKKLILLDIAPTLDMYEKTDDRFASVYWHWFFLLQPSIPERFILADPHAYYNALVTRFPRTTPSSGLGSAQTAVDEWRAGVHLANLSRESSVAAMCEDYRASAPADAPDLDLDRHDRQRGHKIACPLRVIWGKHGVIHALYDALDLWQKCAHQKVEGRALDCGHYIPEEAPHEVLAEIKSFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJN5</accession>
    <name>W3VJN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab proteins geranylgeranyltransferase component A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJN5"/>
    <dbReference type="HOGENOM" id="CLU_021695_3_0_1"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="69621" checksum="0C8CC8112D491A32" modified="2014-03-19" version="1">MSLDQSHYDVALFGTGLTQSILSAALSSAGLSVIHIDQNDYYADQWASLTLSELLKWAANASTTSEPEQRQNRRVSDVSLAFPASAENEAPQSSISSQLPQSLVSLDRHYAISLAPTLLPATGPSIDCLISSKVSSYATFRLLERTCVASSSARVPDGSAMTLTSVPASKEDIFKTKTLSLIAKRKLMKLLMYIATEDWQSELAQDPETAKRPFADYLAQVHKMPSDLIDAVAYGVCLCSTPHETTETAMSRAKSHMSSVGRYGNSAYLVGQYGGAGELAQGYCRASAVKGGMFILAHQVRSANYDKQAAKWSIEVEDVDSTITSDYLVSSDDMLTQLGLDSSAAASNAADPSRKLDVLHRAVVVLEKPIRFSTAHVPETKAADSTQQDDDQPQEQAQPELPPETGLVVFPPDSIGGNANTVTVLMMGEGTFSCPKGQYVYYVQTEASEAEAQKPAREILQPVLDQIVAWTSYDEASDDASQPRAKPLVELTYRQHVSSHAGEHDGPVLSRIAFPPPQAEGSPTPRPTASIAGMTDAAVHQAERVYYDILASRLPARVGGEGHDDKVNWIKKAVEEQKAERKRRRGRDPSEYRGRGGRGADDGITAAGQEAETGASPAQGDAYVVGFFESSSNQDDDDQDEADEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJP8</accession>
    <name>W3VJP8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJP8"/>
    <dbReference type="HOGENOM" id="CLU_103851_1_0_1"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="167" mass="18912" checksum="D50028C522974164" modified="2014-03-19" version="1">MAQVLDIAMKIPERIRSMRQERLSSLRPLSEFFDHQRISRPQDTNEAFQRITYNTRHFSGNYAVVVALLTVYGMINDMLLLFALVFLVAGFWAINRFAPEPMQVGEHVITQKSLYTGLFVVGGLMLWFASPFGFVFWLVGSSAFLILGHAAFIEPPVSSEYTGVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJU3</accession>
    <name>W3VJU3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="10">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PIM1</name>
        <name evidence="15" type="ORF">PaG_05024</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJU3"/>
    <dbReference type="HOGENOM" id="CLU_004109_1_0_1"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000019">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000184">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="179"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="992"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="92"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="875"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1191"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="911"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="928"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1191"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="1084"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="1127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="661"/>
            <end position="668"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS61082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1220" mass="130491" checksum="104248FC2812A62C" modified="2014-03-19" version="1">MIPSQRYAAGSATRWRTSAVNAATMNSRRIVSLSSNLARAAPGPSALHLAAPRIGKSIDAAASTALRTVPARSLFTSPTHRLPRSRKLEKMLEDGEEHQNEENEIDEDDQHNKQAEQTGAKAESSGSSSGARSATGGAAASGSASGSGSAAGGSSSGSGNGSGSNSLARSTVPSVYPQVLALPITRRPLFPGFYKAVVIKNQAVCAAIKESLKRGQPYIGAFLLKDEAEDADVITDLSKVHKVGVFAQVTSVFPVQGGGQSGGAKKGKDGENAEEEEGITAVLYPHRRIRIDELITPTGQTIPSPPPGTEGAGPANPVSDEAANEAVKAASIAKVHDIQQEARDDGVLPEVNDASAAHLQQNAPPAPPKPSDAESQPEGDAADAQDMPSHSTPFQTSFLQDYAVSLVNVTNLAAAPYDKRNDQYIRAVMSELISVFKDIATLNPLFRDQIANFSISQGAGNVFEEPEKLADFAAAVSTGEVSELQAVLEALDVRERLQKALVVLKKELMNAQLQSKISKDVESKIQKRQREYYLMEQLKGIKKELGIESDGKDKMIEKFREKAAELRMPEAVRKVFDEELNKLQTLEPAASEFNVTRGYLDWLTSIPWGVHSPENYSISNATSVLDEDHYGLKDVKDRILEFLAVGKLKGTVEGKIICLVGPPGVGKTSIGKSIARAVERQFFRFSVGGLSDVAEIKGHRRTYVGAMPGKAIQALKKVGTENPLILIDEVDKIGRGHNGDPSSALLEMLDPEQNGSFLDHYMDVPVDLSRVLFVCTANTLDTIPQPLLDRMEVMEVSSYTADEKRHIARGYLGPQAKEASGLQDANIVLPDETIDFLIKHHARESGVRGLRKLLEKVYRKIAFDIVKEHGESVFPEPKEGELASAKTELASASATQSATPPNVDGQAADGASAPSAFPEPSASTSEAPDSKPLQDGKVPGKDAAPEPPAKVTTEKRQPMAVPKEVKVEITIDSLRKYLGPPVYHKDRLYTSAMPAGVSTGLGYLGNGSGSLMPIETTIMPGKGSLQLTGKLGDVIKESASIALSWMKTNAFDLGIVKDAKDSLLENKDVHLHMPEGAIGKEGPSAGVAFTVSLTSLLTNRSVAPTLAMTGEVSLRGMVLPVGGLKEKLLAAHRAGITKVILPAQNQPNVEADVPKAVLDDLEVHYVNNVWSALNHAFGEGPWSAKAKEMEELERKEAITSEQPKQKIMQDDGASQDQPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJX0</accession>
    <name>W3VJX0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJX0"/>
    <dbReference type="HOGENOM" id="CLU_041178_0_0_1"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="196"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="364" mass="41733" checksum="C874B65FCBDFE607" modified="2014-03-19" version="1">MVATRVQAAPASSKGKSHSPQPVRPSQGPLKSTWHRQDDKHGWGFFHWLIHLIDIDPLPPASTTIVHDKDDPIPVWSNLSAHLFIWPRFGAAFALQYAYAHFTGHNFGLLTNMLFWGTYVALYGINVIRSTRTVAQRIGFLQPHKSRDGIPDHRVREVLQSLAMTGFLRPVAATLLCYDPSQDMTLSPWLPVLIPVFAIAVDFWFYWYHRAMHESETLWRFHRTHHTAKLPTTVLSLYADSVQEWGDVLVIPLLAHLTVRLVLPMGFHDWMLCWSYVEMLELMGHSGIRCAGTSPAFDCLPLAKLDMDIVIEDHDLHHSNGWKKSGNYGKQTRIFDKLFGTVMPRVEMLDHLIDTSDKVWFPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJX9</accession>
    <name>W3VJX9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJX9"/>
    <dbReference type="HOGENOM" id="CLU_027089_5_0_1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833257" evidence="7">
        <location>
            <begin position="26"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="487" mass="51428" checksum="3E8FA75692D1FE52" modified="2014-03-19" version="1">MVRFSKIGSQVAVVCAAVLVARTGAQSITTAVTVSGTPTTTVIAPSPTGRGLCDFHIDHWDCDASQPEATASATQSAAGIEPSPVGQVCELHVDHWHCDSPTATAANAAAEPSPTGQGACHLHGDHWHCENESADEHEGHDHSEDSHAGHNHGGSHAGHNHGPSAEYGCGLAPPAPYDMSLHIASIFILLAASAFGAYLPILLYSKTGAKRWGVWANEFFFICRHFGTGVILSTVFVHLLSHALIYWSNECIGELTYEAPAPAIAMAAVWLVWVIDFFLLRSLRNRSGSARTCTHEIEDAVDTKETSSAGSVEGEERFGGLTYAQAKVAEWDVFAIEAGIIFHSILIGVTLGVATGSGFVALLIAIVFHQTFEGLALGSRLSLLVWRGVGAKLLMATMYVLTTPVGIAIGIGVRETFNGNNSTTLIVLGTLYSVSAGILLYTALVELLSGDFIHNQQMQRASLLRAIAAVSAVTIGAAVMSVLAKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK57</accession>
    <name>W3VK57_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK57"/>
    <dbReference type="HOGENOM" id="CLU_008644_0_0_1"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1002" mass="108209" checksum="F4B0FA79C7DFE699" modified="2014-03-19" version="1">MWLLQGRFAEDSRQELSKLLKYGQTYTIGRKIPADIVVDSKFVSRNSCHITVASEQSIETRLAAATDPLAFHNDVSLRPRVTIRFEANKSRKTFAVTKQSAPPSTSTSTTTADPADGIEVHVPPDQQHMLEHGDAFALTTTISLRLVWQPFAVCFAARIKENAIAPLRQPALQLGIHLSPAKSRWKDGYTHLCLAQLNSTESVLCALLQARPLVSIDYFHELFRRAELPRHDPASLETSFDDLSPAAYVPPVDPGELSELIDTPDRLVPDQRRTYMLKATTCVFFALPSDQAEVGIYKNVLAVAGAHVFTHNPVAEKLETKADFAQLLMPYKNSALSYWRNSSAKARSEAPDDGLVVLVSGEHAESTWGHACAVACSNLRIAMPTGFHGLTSAVLTADVRAHLNVFPNMPDDDGASMPPPATMPGSSPPPQPSTPEIRAETRPNNASAQKQPSPMRVEAPAAAPVEHRQTLAKDAPMSENVQSTQSAAEGQRRPLTRRTRKPVSEADDTTSHTTAMYPPSTSARAPADIIDANTTDGDTSESLEPQGGLQTARSARSGLTRRTGATRTNSRRSDIFDAILHTGDANASADASGNISGSAGTQAGGAASVPRSRRYRMDLDEEDRAQTQSLVDAQASSQSQAVDLGKRKSPPPVVGDETAPTSKRTRTEVPAADPAPEATRIVRADADAAQGLAEGAQPDTEPQFLAALDTQRAQVSAVDDFDADFNRLTIAKTASGPLDRHVASRSTKAQTQPARKDAAVDEDYEAFKRMAEEQLRMHVRGNFVQVDFVPLVRKQTVRTATATNAGPNFKKFRRKAEAGAQAQDAQVSRTQVALTLPESNDYGLGEAYWEHNDETSLPHEGAAATRRGRAKVALNPASVEGGSVDLGLDDLDEESDDGADMTTLLERRHGRPSQRASQARGRKRPVAMVDESDDEVVPSRVVPRATAKAAKTSAAMVLDDDEDGDDDADDDGNFAGFGRSSSTRRRRDVPATASGRTRRTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK85</accession>
    <name>W3VK85_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05116</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK85"/>
    <dbReference type="HOGENOM" id="CLU_118199_0_0_1"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="159" mass="17193" checksum="B6E2A6D292B6079D" modified="2014-03-19" version="1">MFARSAAVRSVARQGRHFSSTSAARATAQENASSAINDISKKAQEIGGPVIKRVEGLLGGYSEPIKYNLSVASSVAKQVYVAEALAPPTSLNTIVSAYRQIWSKASDKAFWAQMLTKGDWKKVGIYAVEAYGIFTIGEMIGRRSLVGYKLDTSKHSHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKA9</accession>
    <name>W3VKA9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKA9"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="545" mass="57888" checksum="70C3963BE8C54498" modified="2014-03-19" version="1">MSQKKKMAGSPKHFSSGAEITVSELDRQAPVSFVGDGGEEARLDPTTGDGVLGKKLSTLGAIALGYTSLSTWIAYSASAATALASGGANVLVWGMIIVGVCNMAAAITIAEPASQFPNASGQAAWVYRLHGRYLSYLTSWLVLLGYIFLSVAAQLITTVILLAMINLTFPSYVIETWHVSVSIVATAAFSFVVAGIASKLVSRLNVFAFTWSVLGLVVVVLTLLIQSRGKYNTVEFALVDIVNVSGWGNNFVPWVLGLSQAALSTTAMDVPTHFSEEMANPARQVPIAIFGGLGTSIVVTLAYAFVLVFTLPELDAIITTSTGFPFAEMLRLKTSRSGAIVLLLIPLVSFLITSADVAMAASRCIYGFSRQRGFPFSTFFGTVNTRFDSPLRAGLLVLVCQSCIGLIYLGNTAAFNAIISVPTLLLAVSYAIVAGVCLAARYRAGRAEPSGGTVDKQAGSMGSDSSEGDGAWDPPFRMPKWLTISANLLTIAFTVLLCVFLSLPPTWPVTSANMNYTSAFLVGSFAIPAVCWIRYRHAYEGPLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKL6</accession>
    <name>W3VKL6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKL6"/>
    <dbReference type="HOGENOM" id="CLU_032509_0_0_1"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000054">
        <property type="entry name" value="Chromosome 16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF268">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="31"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="539" mass="58276" checksum="6146C742249B6DDA" modified="2014-03-19" version="1">MGSATVEEFVELLNAEQHVDLQKLRDLARHGVQPAVRGEVWLYLLGVLSDDKGQEMTSVRSKYLEYEALDKHNPALEKRVRSECQRYYQKRLGTRPPPGRTLMRSSRSVAARRPGGYSGGIGSAGAGTSDGPGAGSALGGAVAAMGSPHSVMPAVGTAGVATATLLGADRGPNRVNDGRIHALGGIIGESGVSAAMDADDPDAAAALELKRFGRSVESIVCAFMNRCAAAEAARRRAADAINAAAPAIYEPETSTSQTATHASEASNDERRQVEYSPWGDDTSRSTEAGEGGNGAATTRSNGSRTRHTQSGVSSSRSRSRAGSMSGGSNAAGGSGRDKASVEESVRSRMPREYEWEPQITTAAGGRAGTASEFHPALVYLCAPFVQCVRVEAGMYFAFEKLMTLMARHSARHPLPRQVATFLTLFRTTLPELHSYFEEEEVDIIGFATNWLQHLLAGELRIEDLMRLWDTYFALPDFMDLHLYVCIAILTNCKDSLEELDRSETRSMLDSLPPLDVDRIINEAINIRLSHQRSQRTDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKS0</accession>
    <name>W3VKS0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone acetyltransferases subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKS0"/>
    <dbReference type="HOGENOM" id="CLU_311712_0_0_1"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="94763" checksum="8B8A1D01DC1E8C94" modified="2014-03-19" version="1">MGGKDANTGLSRSASRDVGASAGIHSSARSSTGNPFYRQFLPSLLSNISPNDAIPSLDELSALAKHLERIKAESSARLARLETRSSDPFKPIFFSAPNDLFSPPGLPSGPANLYSDSSRQASSAGSAFASISKYQKARERSFASPAPSASGANVGGSTSTTAAGGAFASKNKVKIKRERDNDSAPASSLYSDVRSPSNAASKANARSKAARAHSFDVGGDDESVVSTDPEWDLDEDMPSRPGRTYAKNKKRRRKDVDADSNEDESGSEFEAGALLGAAGSSRNAATSKHVGSSASASAARTAAAVPGSISRRGSEVDTSSGGVATPKIPAIGMRLKANAASQNAPGFPRKASDATQVSTRRNSVLPSPSPLPSTPAHLNAAMVAPVIYQPAPGWELPARTPATFMPKLEKSRKPRAYPTKPQQVNEDFANKDWKEKERERDRLLERESIGPGTPGGPGPGQSMVKEATTGRRGGRDLQQTPIHTFYNYADAFFKTLTEDDLAWLSSKSDDHEPFQMPALGRHYKQMWEEEDALIASGAVDAYGNPLSTLSRSPSISLGVGGGLPLDASLLAASRSGGADESKLAQRPELEIPPPPSFRTKQMTDEHLGLESPAVVDARSGPLAERLVASLLPPRQDADDGDASRATGSADDGGSALPMNVLARLNGHAKHEDETGDDEDADGEPDLDMQGVVADQDMATFEERIAKELKAIEVLGADEALDWSSRQDDEISTTLRMVQRELARQQKVNEMRKDRLFGIAKDRMAHQDYLNCLHSLEKEIEAGWTRRLRQIKASLGKRKKGGHAAASHHDDLSQPGANGIQSASGTPQPGGVPYNGPVRPQLPENLVSAMEKRKKLQFAFKELFDEAKHAWQTPTESVYADLHLDAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL36</accession>
    <name>W3VL36_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL36"/>
    <dbReference type="HOGENOM" id="CLU_005027_2_2_1"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="346"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="642" mass="71905" checksum="47727043D641154A" modified="2014-03-19" version="1">MVSSSSLSGSRAKADVQVGKSSPRLRANVFPSNTGHQALKDDAHPRGPSSIKHRGCIDDTAVFWDHYRSHKLGWSVAGGLAFFAFVLLFAKASSTYDDVQPIGYLPTTSSIFETTIVSMEDVNAACAQAGIHPIACKVDHAAKLASDLRARQSKTPEQAVQAYRRRYLRSPPRGYEKWVEFALKHNATVVDDYDQIEVDLSPFRQAGLRGDKLKRRILDAKAPLPGYEFGQVGVVNGKAVSFGPDFGPLSAQTLMEILAPVQHLIPDVTIPFNWYAEPRVPHPSQSPSSGALRSINTSHRDPTAILRQACPSNHISPGRPWNDLEPPIDYCGEDINELSELHGFLQAPDNFHPFTKLVPMLSRSKLSNFADILVPNPCYGSEVYRGLPDNIPWEKKRDSVYWRGSTTGVAQTPTTWARGHRHRMMRYVKQLREAANRLNNGAEVDPMDAIYASNRTIASSRKSVNVAGNTLPLFDYTDRPVVEAVKRLGSEAFNVTWSRFVLADEPTLASLMANQVTTGLEERNDVYLHKYLLDVDGQSMSCRFYQLLSSNSLVFKQTIWSEYHDDRLVPWIHYVPIDLRVENNELPMLLDFFIHHEQGPKTAAKIAAASKEWSDATLRQIDVSLYYARVLIEFAELYHQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLA4</accession>
    <name>W3VLA4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLA4"/>
    <dbReference type="HOGENOM" id="CLU_595992_0_0_1"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="459" mass="50773" checksum="06ABA15FE1A8D3CE" modified="2014-03-19" version="1">MDAAPEPNLEIQDLDSWLASVATTLAPTTQSADAATALPTWLQEALDGAEPGPTAGPSSAGPSTVADGSTSETSGPSKSLERIRRKNRLAQQRSRQRRSEHVRELEDQVRQLRQLLELERQRNATSESNQLTPSQRRNTASHGTNKEVRGSVSMSRLLAMLADGTLDDRFFPLLGRHFDNSSIHRRSDGSLRSALTDPDSAISWQVSFNTDSSNFARAASTQLGLPSAIVMPELVLYKVCRFYFRLLLPFSTSFGSGMVNLATAELMQEPESVSARWNRHPSEASHSLDETGTLPELLMPTRLQSTVGSHPIEIAIIPFASLRDRLLLTVLAMNGTQSFEVEDAAGTVWPDEDMIYDHTFSTKPNSGKPIDRAQTVGSRPAALRKDPLCPAARAWLDEFMVDFVGSLRVWNASDDCFNTTAFELRPQFVAKYRLLLDADLIRTSNFWRSSRGEPSLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLF2</accession>
    <name>W3VLF2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLF2"/>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="555" mass="59720" checksum="13C86CD1515E392B" modified="2014-03-19" version="1">MSLKVPRAGGPNLFKEGYKHFQGIEEAVLRNIQAVNELSEIVRTSFGPNGRNKMVINHLERLFVTSDAATIIRELDVVHPAAKLLVMASQQQQAEMGDATNLVLIFAGELLKKAEYLITMGLHPSEILQGYEIARDKCLAELEQLSVATLSTPPTPQSLALALKPCLASKQYGNEDLLAPLVAEAVSMVLPQNAKNGLADFSVDNVRVVKIMGGSLSQSKVVRGMVFGREPEGVIKKAKAAKVGVYTCGMDITQTETKGTVLLNNADELSSFARGEEQQLEKYFKEIADSGVTVVVTQSQVGELAQHYLNRFGILVIKILSKFELRRLCRLLGATPLARLGAPLPEEAGWIDSIETTEIGGDRVTVFKQEDGQPGGKAKPKMCTIVLRGATSNLLDDVERAIDDGVNVIKSLTRDPRLVPGAGATELELAKRIVDLGEKTPGLNQHSIKKFGEALEVIPRTLAENAGLDATETVSRLYAKHVDSAGADVGVDIENETDGTVPTTANQVLDVLAAKSWALRYATGAAISVLSVDSIIMSKPAGIKAPKANPNWDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLM8</accession>
    <name>W3VLM8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLM8"/>
    <dbReference type="HOGENOM" id="CLU_286689_0_0_1"/>
    <dbReference type="OrthoDB" id="2554528at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1040" mass="116798" checksum="1BDFDD0BB2D4AAC9" modified="2014-03-19" version="1">MPTATRPKPTAPSAKRRPSGAARSESGYSRRSSLGSFKTAAGASDYNPAISASEQDEDEDEDEDELASDEDATMIRKHHAPRHLEDDDETETVSHHEATPKGLVAPGAEDSSSVESQESPAIFNHNTTSDTETINKSPPTSHDDAVDQRSPLDKSKAARQLLTPDTALTPKGKDRKNVRASHASHLTLPYQRSEAGDMDASRRLSKMTMQSYGRRAPSRAESFVDDMPDMSMRDARYRSVSERGGGSRASRLAPPASVLEFGGASARSSFQSQRGPGSRYASSYIEPHSLRSPSKRDFGSPAGIHHRDSDRLSISSRRTARKPASVVSKMLDADTQVYPGTRIRKYIEPQLNEAMRRVMKQFAGHGLHDHRCNGYPIAVFVGATAIDTGSIIQPHVSGAVSMYFGPGHPKNMATLLPGEDRVPSHIPNPKAPTPASLSRRAELRSAITALHTIYEMYRGRACAHVCIDSAYVAKAWGTWIPTWELRGWPGEDDQEAGDEERWEEEYYERRRNQRRVYDRYGARYEDRRDGYASDGGRFRRDAPRRKYDDDWLASDPYADRDRSRRRGGGQRRSRGAYDYSSDEDEYDRRDRRRYDERDDRRRRPMRRAPGRRLVDEDLLRELADIRYEFARAERGRHGSAHLYLIDRSNNPADRMARAVAKSDGNLLRQELEALHVDDAAFSDDELLDPEEEEWEETRSRFSSTSNTKGRMSSRNSSRGSIISNATGRLRPSASMPSGRLREGARRQLDTFAEEDEDEIDDARSVRSARSAKSAKSARSKKSTRAERERDEYLARQERMDAEALATQRRSVAGKRSASRASHLAPPASERGGGSRRSMDSRAGRMSTDMLSPEAASRRGSMDTRRVSAVRSQPDIRGSGRASVRGALASAAVREDDVHEEYYRPSMQVHRDVSGGPRHPSHMEYPEMDDLVPPARAWDGASMRSRSSVDSRRGGLFARKHDSPKSERKFGMFSNRSTPSLRAAAPEDPDYEWKAKRKGGRKQRDWNATTADDYAQRSQWDADAEERGKKPGFFGRMFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLS4</accession>
    <name>W3VLS4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLS4"/>
    <dbReference type="HOGENOM" id="CLU_694443_0_0_1"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="172"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="428" mass="47840" checksum="22B748FD6783E865" modified="2014-03-19" version="1">MRPVSARSFWLARPAHRTASPRLTSPCLSVCSLESVPRLEGGKRWSVPTRTHAFLPPPLSSLTSTNPLSPPRVTLIIIITIIIRIHLFTSGMRIPTIDLHHWHTCQLCKGAVAIHARHIGLASSASTRVLTLHPQESMIVVIVYLISRLATTMLFKTNFFSSTSYFTMPESREDSVYLAKLAEQAERYEEMVENMKRVASSDQELTVEERNLLSVAYKNVIGARRASWRIVSSIEQKEESKGNETQVSMIKTYREKIEAELAQICEDILDVLDKHLIPSAASGESKVFYHKMKGDYHRYLAEFATGDKRKDSADKSLEAYKAASDVAVTELPPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQDSEKPTEAAAADAPAAEAKGEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLU4</accession>
    <name>W3VLU4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03117</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLU4"/>
    <dbReference type="HOGENOM" id="CLU_014420_1_0_1"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="209"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="773" mass="82608" checksum="47D495257DAA04CB" modified="2014-03-19" version="1">MDIDSPQPLTPPLPPGHPPADGAGGSGNPPQPLDPAAAPHKRKYDHLTQHNADSYPIPSEPSSPAPHPSSPPPPSSSPFPERSASSTPAPASISEAQKVYIARTAPHLLGRPPAQPASRTPSLPPSGRSSPSDEDGRSTPDGTASTPTAHNQSHHTLPQGYRGPALRRNDAEDFAPAPHLAPTVGSTTLYNTVNFAVNRNGWRYTAAGPASQHLPHTLFKTLETLPATVHWCWSDRSPFTKISAAADIVSTDKGFRGARTNIGVRQGEWYAEIEILPPEHLAPGVGAPGPLPAPMKDGSHIRLGWARREAPLNAPVGFDGYSYGFRDKTGDKVTLSRPLPYGQPFKAGDVVGMYIKLPQPAPPQDENDPANIRRERIPIRYKGQLYFESLENPRTREMDQLMERSRKGNSIEEAHQGIQGTGVFEPLDPTNPASSEAANGVAAAAVNGAGASGGASGSAKVKNRKTTAAKDKPSGPATPSLRPVPRIAGSKIGFVVNGVPQGIAFRDLFDFRPLRVKGFSNLRPAPLKPTGRTAKQDLKKPELAEPVINIRARENVFDDGALGYFPFVSCYGGARARLVTGEHGFKFPPPADIEAALENASSAGPGWEKMEESEGLAKWKPLAARFEEHLAEMWQYDMQDEARAQATAAKQAEEREKRNHAAKERYAAAKKKHAAALARNSAASSPHPEHEPDAAEADTAITAQHDARMDDDMPESAPATVSVVKLENASAERPVEEVSESPTPAYVASSPPTTPPVQPALRDDDVDMVDSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLZ6</accession>
    <name>W3VLZ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PaG_03226</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_6_0_1"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000073">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1110"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1136"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1188"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1214"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1274"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="165"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1076"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="335"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="446"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="831"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="860"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="941"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="942"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="943"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1023"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1029"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1049"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1052"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1053"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1053"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ETS62589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1312" mass="143995" checksum="CB2B7011DBD416AA" modified="2014-03-19" version="1">MSSNPATSSTWSPEPDGAYPLQPLGSSANMSAGRSSPAPSYHSQSENGFAAFRSRNSRARFSRFGQNNARDSEEQQGLLQNSEDAISRRPDGLKRTDSTPRHSEDHRRQYGSHADSDGIPAASSHHVVQLGSRRAGLIASLFSSRDRKPRDLSRSISLGDSDRVRSRYAANVVRNQKYNILTFLPKVLYEQFKFFFNLYFLLVALSQFIPALKIGFIATYVAPLAFVLCITIGKEAIDDWARYKRDVESNSAPYKLLVPNDSALAKAQTRLARKATPNKPLSLGSDLGQSRVVQVPSSKIKVGDLVVLDKNQRVPADMVLLQTFSTDTAIGTSGGAVAPTPMDDDAQFVLGDDEDGETSLDKAAETSSGKSGSASQDQGDSSAQGSNGSCFIRTDQLDGETDWKLRIAVELTQRMPTDDLAVLGDRAVVFAGPPIKDIHSFLGNLTLHPPPDDGSSTPPPTVHRSGPAVGDLLGSAADGAGPARGSIDSHPADTVIPMSQQPQVAPLTAENVLWANTVLAAGTAVGMVVYTGRETRAVMNTSYPGTKVGLLDLEINRLSKILCGVTFALSVCLVALNGFKGEWWIYIFRFLILFSSIIPISLRVNLDMGKTVYARQIMHDDEIPGTIVRTSTLPEELGRIEYLLSDKTGTLTQNEMELRKLHMGTMSYSWDSMDEVTSQLATALQQHYGNAAQPGSPTKPTPASGSVAQQPISLTTAGAMLAGRGRRDMSSRVKDVVLALALCHNVTPVVEADGTVTYQASSPDEVAIVRWTESVGLSLVARDRKSMSLRATDGATLHFDILEVFPFTSESKRMGIVIRERASGEITFYQKGADVVMAKIVAQNDWLDEECGNMAREGLRTLVVGRRRLTHDNWLAFERAYKAARVQVEDRNEAMARAIEEHLENNLELLGLTGVEDKLQEDVKMTLELLRNAGIKVWMLTGDKIETATCIAISSKLVARNQYVHQVAKLRTHDAVRDMLDFLRSKLDCCLVIDGESLQLCLDSFRDEFIELATQLSAVVACRCSPTQKADVARLIRSHTKKRVCCIGDGGNDVSMIQAADVGLGIVGKEGKQASLAADFSITQFSFLTKLLVWHGRNSYKRSAKLAQFVIHRGLIISIIQAVFSSIFYFAPIALYQGWLMVGYATVYTMAPVFSLVLDRDVSEDLALLYPELYKDLTKGRSLSAKTFTTWLMISTYQGGAIMILSLLLFENEFLNIVSISFTALVVNELIMVALEITTWHVYMILSEIVTLFFYCVSIVFLPEFFDLGFVLSYRFLWKTAVIVAVSSLPLYVWREVRNRLAPPSYSKLAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM08</accession>
    <name>W3VM08_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM08"/>
    <dbReference type="HOGENOM" id="CLU_277735_0_0_1"/>
    <dbReference type="OrthoDB" id="10575591at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1141" mass="123256" checksum="9A50C5C9EA1E48D2" modified="2014-03-19" version="1">MHERDDRSTVPLFSPSSMKAVAEMSRRSGRRAARHCHAGNAFVPKERRPAGYEQPRAASSSLEVNALPLSRKARDARAIVSASAPGRRIKAACAACTTRVNAGCKAGPKARSRKLPSASLVKTVNKASSGAATRNPAILINMSGIYCAFAAEQQLSRRWPRRGKISLRPWELRSAAGFERKKLACVRGSARETFGLPPSEGNAVQWPGWWWGASPKAVVKSTSPIARRHIWYGSKAGRGDSADKKRAAPVPRPKAVVSRDDPHPAAPPGEAVIRAHGRSKDTRAQQWGGSAERHDSTDIYGLRYCSLPHIPFGLPAKTAVSSLEIQHARIRLDRARMDLPAEARLGLPAGRETALHSSARPTANIALPRRAGLARKDASPAACAVNAFATRPLRRAMPARSQSTGDRGEVAAMIQWREAFRRDMQPHFQPKLNRRRRPLVADQQGSAGMKINPLRTTGLQRRDSTASTNEDEWEPHSSARSCRTEHGLAPSRWHGVALRRTSRPLPGALFAIRFTTSTRGPAETLYAGVAVTRRLLCHAHGACGAANVFAALLARAAFDRTGVTSLGQASKVVFLSATVATAATSSVPSMQMGRLHLPKTELQVHARGSPVSAAFGSSKVFLCITTLSDPWPLTAEQREISLSSLAPGMPDSAPWHLGRSQPANLGSLFHASKPSIQSGSADKGAGVARRVVHGAASRNLGNMDEASRARVTSRPVLPPSKPTCPAELAALNPQTLRGRRTERTAVCMLHTTLSTTLRALLRSDCKVSWLVVRSDLTPGNLALSPAEKNQTFEPTCVRHHISRAGLDVVRDELASTQLRHPLASGPTVLHFVRSGTRRLSFKELAGSSRNIRPAAATSECEFGTRTLNSRNPVSMSHWLEPVLGSRGLEPHFSRPVSLRRFLRGRLRSPVRAVKASCHVDQCNNPLTVQLSSGGGLPNIRLPCCRGEAELHVGQAYSHDVVRALTRPYSVANPGEFRPVGRYALRHASQHGGGRRRPGTSQPCYAIAKTGHAAHIWATARHVPVHTTAFGVYLPLPGLSQASRALRDQQGRQDSAWCSHGCGPGSAISPGTLSYAPAIHQLTVTSELRYFATSLLRYSATLSQPPEPTPSANTSLNTARRTLRGTIPNESTLESSANQWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM22</accession>
    <name>W3VM22_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM22"/>
    <dbReference type="HOGENOM" id="CLU_633122_0_0_1"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="357" mass="38982" checksum="A87668C459D40777" modified="2014-03-19" version="1">MDVHASWSAGQLEMQKVFGHGRVRPAVAVRSDAASHAASWLTKTPSCGPVNPSAADLLVHAQPAIPTTCVLNAPSNLLSVKVASEGNGGLDLRVSAGASIDGGDSSSAASICEWERAQKSVNMAAQAQQVQQKVEYFVAQIDKELSRYPALKKFEQTVPIPKAYAALGAFGIFTLPGRSRRAPIGWEQRSASTRVPLRIAHFSQCCCPTARRKFRPGKDNSLIIFAPAAALHSSLPRQFVFFNIAAGFLTNLLGFFVPAYFSLKALESPQPEDDVQWLTYWVVFGMFTFLETFSSIVLYYVPWYYTIKTLAIVWLMLPQTQGAKMVYSKVIRPAFLTTQKTVHKANASTPAAPAETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM60</accession>
    <name>W3VM60_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_03298</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003364_0_0_1"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.260:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="12">
        <location>
            <begin position="576"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1438"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1489"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1494"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1579" mass="174147" checksum="177A81D62B6BC926" modified="2014-03-19" version="1">MPLAKRAKVDVSSAFHLGFFLYALSHALPPPSTVHPYPALIAPIAHPRAPQDTPSSLLDPASNIDSTMIAKQASLARASSASILSSASTSSTRCMRLPSTSATAPSASLARRSPLAAQSLSFSTKGPRSQAIPAAQTHVDHQEPHDSSSAASSAASSSSTASQASPSSHPSASSSRSDRRSRFMPFAFATGSPLTRLPTPLPQDVAERSALLRRQLQPKTKAGTPIPTTSPSLFGDTMAGLSFGDLSGLTMSSADESYYPANKAVEYVSILKACLGTGLISRAHKVFADLRTQAASRSRELWELRQRLAQGIINQNDRHQDLGELGAYQSPIEVWTYNSMLQAYFRKAYQAESLEGTAEWLTRAWELWRDMENASRAAELDQPPSPDPSPNPATYAIMARGIVALQRSGRYPSTAPALNDLLLSIKRADYGLDSILTSPAFNPQSAEDPDVTGPLGSTSVDQSREGEVDAEMVLRSLTTVANQMGETGMLKELETAQSILEGRRVLSEAQSGEQLSNYDPLADVPELLPVKTTSKASRVGNEPNNKQGEMPFNLASLKGNLSIVQEARRTISDPYERQKWLEHSAVEAARKRLEHSAEKLEELGLQTTGALQSKPLQKWMWDWYNKLQTALNKDLDRLDSDLKNDVHTSKAMLPIEQQMLPFLRLLPVSKLALITILELMRMSGNGGVSDGMKTTRALLQVGRAIETEYHSEVIRKNPKIFQNAQAAQAALKKRGLVDFAARREIKEWQKQQEEQGVISSIPKWTQITRARVGSYLVQHLMQVATVNRKATDRDGILWEEDQPAFYSTYQYLGGKKLGVIKLNEVVAKRLDKDSISETLHPRHLPMLVPPKPWTSHDSGGYYSVRQSAMRFKDSAEQGSYLRAASDNGDLDTVLAALDVLGNTSWKINKPIFDVMLEVWNSGKDIADMPPMEMETPEPVKPDNYDHDIKARSVYLQRLKQWNQQRSSNHSQRCDVNYKLEIARAYLGERFYFPHNMDFRGRAYPMPPHLNHIGNDLCRGLLMFADSKPLGKAGLRWLRIHISNVFGYDKASFGEREQFAIDHEADIRDSVERPLDGNRWWLKADDPWQCLAACMELRAALDHPEGPEAYESCLPVHQDGTCNGLQHYAALGGDLAGAKQVNLSGGDRPADVYSGVADLVIKVLDEEAAKGDRTAKILQGKVTRKVVKQTVMTTVYGVTFIGAKNQVMRQLADRGDVPAEDLFNAASFLAKVIMSCIGNLFSGAQKIQDWLSFSAKVIAKSIPGQRVEEATRPYLPNEANLRRADVRGFSRDPAKADRIAKEQMTSVIWTTALGLPVVQPYRKAKKRQVSTSMQTVFINDPLLNAEVSPAKQASAFPPNFIHSLDATHMILTALECHAAGLTFASVHDSYWTHAADIDTMSDMIRETFVRLHSQDILYRLREEFLQRYEGYKVPVVSLQSAQRRRPRSKATAVEDGVSSTSSPSETVLAMPADELAKLAGDEGEVILGKPSKEAAEEDGDDVDSAEVAATEEGEEGEDGEAAAQAPAKKTRSRKSKAEKDEEWESKFKAKFVNLADILPPIPAKGSFDVNEIKRSLYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMJ0</accession>
    <name>W3VMJ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02615</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834695" description="1,3-beta-glucan synthase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1093"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1175"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1200"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1261"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1332"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1943"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1992"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2083"/>
            <end position="2103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2109"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2198"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2232"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2274"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2304"/>
            <end position="2330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2432"/>
            <end position="2456"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="947"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="657"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="765"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1538"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2470" mass="275994" checksum="8206B8F8E7C36939" modified="2014-03-19" version="1">MSPLFVVRIVAFWITAEVAAQTCKDRAVDGSVLLVHGQFLHDASLAGFEMHKQQRKTLLKRQTLPEQLLLKQRTRRRATQSLHGGDQRPLGTDAHSGALLDASHRVRALSRSRTLASHKLQHVALDPDGSDDGRGELPECFCVVVLVGQFLELRLRSASDPLRGLGQTTRKACAQQTHYARLDSAQQDLIPARQGHHRLGTLHPPVVPTKQGNARDPRYDALNLLEAAFARLLRPSMSRHSRAQHDELHIPEDRALVRTGWMQSALQSLSSRRWQYAKHHGRPPVKRDDEVMRRPAVVLLFLPTPAWEQVSRLEASASVRLPRLHAEGQSTSRSQIFPPHRGTAAVTLARGMDRSSSDRRAGRAARVQSFRGSALAAWGAKLNASSLFEISASAFASHPQPRIASRASPCRLEDLRGPASWRSALADANPTPELGFASIFYALEAVHELPKASRGKALGAHVACEAGIAGMRLGAEEGGGARAVAVLWHAKPTPDQLGPRAATSDALAHCLGLQLSLAPSPVPAAAPRSAPPPNRLGSEPPSAVASAHRPSLILHTAASRQPSSDIDSFPSLTPTGRFEAGDIQTRRQVLDCILSIVAVNTASSRLFLFICLALRHPTTVRSTSACGPRVFTSNDYSEATRLYTGCIVSSNSSLSVSRLHDQRPRSRQHKHSTAALSPPLPSPGMSSNHGAGGIPPHHQQPPMNPFAGAAFHEDQGSESGFFPTERRDTYASERSDGELIPGHGYDADSYEGGAYKDSYAYSAESASRGYTPGPGSQFGQGSYAPSGISSPHPDAGAGGYRQREPYPAWTAEHNIPLSKEEIEDIFIDLANKFGFQRDNMRNMYDHIMIMLDSRSSRMTPQQALMTLHADYIGGEHANYRKWYFAAQLDLDDAIGKVQNPGLARAASMANRGRNAGSAAAKLQTASAKSLQSASARWRDAMLKMSDYDRLRQVALYLLCWGEGGQVRFVPECLCFIFKCADDYYRSPECQNRMEPVPEGLYLRAVVKPLYRFLRDQVFEVVDGKFVKKEKDHDKIIGYDDVNQLFWYPEGIGRIILNDKTRLVDVPPSQRFMKFDKIDWPRVFFKTYKEKRSFFHLLVNFNRIWILHISVFFYYTAYNAPKIYARSRNPTTAESLSAAGLGGAVSSLIMIAATMAEFSYIPTTWNNTSHLMRRMIFLAICLAVTVAPAVYVFGFNNKGNIANIIAIVHLALAGCITALFSIIPSGRMFGDRVAGKARKYLANQTFTASYAPLVKSHRAISILLWALVFGCKLTESYFFLTLSFRDPLAVMITMKVQGCSDKYFGTALCSNQPAFALTFMTIMDLSLFFLDTFLWYVIWNTVFSIGWSFHMGLSIWTPWSDIFQRLPKRIYAKLLATADMEIKYKPKVLVSQVWNAIIISMYREHLLSIDHVQKLLYHQVPAGENGKRTLRAPTFFISQTDKGIKPEFFPKGSEAERRISFFAQSLTTALPEPLPIDAMPTFTVLVPHYSEKILLSLREIIREEDQNTRVTLLEYLKQLHPVEWDNFVKDTKILAEESQGFGGNSPFGGDSDEKSGTKNSAKADDLPFYCIGFKSAAPEYTLRTRIWSSLRAQTLYRTVSGFMNYSKAIKLLYRVENPEVVQLFGGNTEKLERELERMSRRKFKFVISMQRYSKFNKEEQENAEFLLRAYPDLQIAYLDEEAPRKEGGESRWFSALVDGHSEILPSGKRRPKFRVELPGNPILGDGKSDNQNHAIIFNRGEYVQLIDANQDNYLEECLKVRSVLGEFESFNVSNQNPYGSGHQEFAKAPVAILGAREYIFSENIGILGDVAAGKEQTFGTMAGRGLAQIGGKLHYGHPDFLNTIFMTTRGGVSKAQKGLHLNEDIYAGMTAFGRGGRIKHVEYYQCGKGRDLGFGTILNFTTKLGNGMGEQMLSREYYYLGTQLPVDRFLTFYYGHPGFHINNILVILSVQLFMFTMVFIGTLNSQLRVCATTNSEYIVGTGGCYYLNPVFLWIKRTIISIFLVFMIAFLPLFLQELSERGAVSAFVRLAKHFMSLSPIFEVFSTMTYSHSIISNLTFGGARYIATGRGFATTRQSFALLYSRFAGPSIYSGMRLLLLLLYITLTLWIPHLIYFWISILALCIAPFLFNPHQFSASDFIIDYREFLRWMSRGNSRSHANSWIGYCRLSRTKVTGYKKKRLGHPSEKLAGDVPRAGWRTILFAEVIFPICLAVIFVVAYAFVKSFHQTGDPPQGAIVRIAIIALGPIVWNAAILLVLFLISMFLGPALNNCCAKFGSIMASIAHVLAVIGVIAAFEFLWFLELWNASHAVLGIIAVIAIQRAIFKILIALVLSRELKHDETNRAWWTGRWYGRGLGGHAFSQPAREFVVKIIEMSLFSADFITAHILLFGLSLPCLIPYFDKLHSTALFWLRPSKQIHAPIFSLRQRKQRRSIVWRYLVLFVFAYAVFLALIVLPAIFSSTIDLNCSFCKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMR5</accession>
    <name>W3VMR5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMR5"/>
    <dbReference type="HOGENOM" id="CLU_774163_0_0_1"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834365" description="40S ribosomal protein S27" evidence="7">
        <location>
            <begin position="17"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="358" mass="38588" checksum="3EE72A2094BA0E84" modified="2014-03-19" version="1">MVCCLVTPRWLVYCLAAAVSISRAPKGPAAVFGSQNKGWIAASQHSAASLNQNSAVSVSNLRVATESAEAELAKPGRLSEAADGDSRTRAGRVYAPAEAGDRDPRQARPCRRPPPTILLPSPQYHTHILITLQDGKISRILATRFASQQNERLLKRRRIGHGQGIRAGGVPLQDATQTLFRVNVVSFSDCSGGIDIAFAVMQDCHPLFNGQILLFTPEIGHPLSADTQSVACRHCRPLRLPSLRHAGDHSHSAAMRDSSCLAEIHTDHGNCPHLAQTLAVDLLNPSTEQQARCHKLKRLVQNPNSFFMDVKCPGCFAITTVFSHAQTVVVCGSCAQVLSQPTGGKARLTEGCSFRKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMY9</accession>
    <name>W3VMY9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMY9"/>
    <dbReference type="HOGENOM" id="CLU_050573_0_0_1"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="349" mass="38336" checksum="DABB851CE5981D25" modified="2014-03-19" version="1">MKIGIHGIYYLLPILTFASWTTAIVGLLALWSKDSFAEYEVEEASIVFISDVGATHKTFFIIFCALTAGFYILTTFAERHLRHLRRIPGSVRKKQTILDICSVICAIIGSAALVLLSIFDAFNHSTVHWSMTLIFVVFVALSVLFQVLQVFSLSHDHDRLATLKVIAIIKSIILALAIAGAIAFIVCYGICRGDANPGDNRCDRIVSAAAVCEWAIAFLLDIFFLTYLVDLWPAHRRAQKGLNADGTMVENKQLAKEQGVDDRPTAPYAIDGVRENDTYYPSQAAQQYHSGHGVQPAPAVNQPSNYSPTNAPSTLPGSERGSLYQTPMTEARPYPNNGPVTNGYSTYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN98</accession>
    <name>W3VN98_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN98"/>
    <dbReference type="HOGENOM" id="CLU_046484_0_1_1"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="9">
        <location>
            <begin position="117"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="349" mass="38340" checksum="7A900B59FBEAFB17" modified="2014-03-19" version="1">MLSFWPTSGGASSSSTAPPITPSSYRMHASGTSIDRPRPAECTATEDSKSARSDRRITVLSVVEQSTGVLGTVLSNPVGAAVAGISTTSLAALLWWRYFRRIPTAEYVTPAVLKYRKVLVGRVVTVGDADGFRFHHTPGPPFLRDWLNPWPPRVRSKNAKPGTRTRLVRETISVRIAGVDAPESAHFGKPAQPYSKEAKDFLTSMVQSPSSPDNLTAPKKSFFSSASSSAPAHTSNDVSTKVVWLYPSHIDQYKRLVATPYVWEPPYVLGKTNVSLAMVKQGLATVYRSAGADYGQATWWARFWRKSTTGLTALERAETKAKRQKTGMWSLGKNFESPEDYKKRIKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNC5</accession>
    <name>W3VNC5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNC5"/>
    <dbReference type="HOGENOM" id="CLU_040908_9_0_1"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000433">
        <property type="entry name" value="Chromosome 16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF14">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833126" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="156"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="401" mass="41873" checksum="946497F1FA2F8D24" modified="2014-03-19" version="1">MLVLNHKLILLAVLVLALFLSNADSVDAKKQCRVKHQKHHHKHHKANHHSSSSAASGAQSGSQSEATSPSGSSSNSSSGSSASSGSSSGSGSGSSGSSSSSNSNSGSSSSSDSGSGSSSSSSSSSSSSSSSSSSSGISISGFSPPLGKAGVAGGNSLKWTAKSLGWYYDWTPNPDNPNRGDILAVPMLWGLGRVDHDDDWARFEAFKKLKPGSAPFVMGFNEPDFSGSGSSGVIPVADAAAAWEQWIAPHAHAGAKLISPSMAMQKDETWLAPFLKAIKTQPDIIAVHIFQDNMDGVKGVLDHFAQYGKPMWITEWAYQGPSPKYADQATVDSIVKQMVDLFENDERVAAYSISDANNGPYGDLTPNQAGQSLSQTGKTYLASVEQATGKNQRRSLTPVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNF8</accession>
    <name>W3VNF8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03344</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNF8"/>
    <dbReference type="HOGENOM" id="CLU_1001146_0_0_1"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000007">
        <property type="entry name" value="Related to MRPS8-mitochondrial ribosomal protein, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31165" checksum="C0983464046A450C" modified="2014-03-19" version="1">MPLHADLCTILQNASRARLRSIPLASTKDNLSILSILLQHGFIHNVVRGTQTGPSPTSYTAASPAARRLWVDLKFRPDDRPVLEKMNVVSKPSRKLTMDKDELLRLATGRRAKFVKPLDMGEIGIVDCGKNGWWEVRDAIRRGYGGEVVARTTISVATPHRISGHATLSSRHRASGVGSTGPVSIAHPSLPIMFGLGSAFYLILFITNALAVLSEDRFLARVGWSSNSLANAHSFDQGFSQAGPYAQNDVTVKARLINLISAVRTLMRIPLVAINIVVVIYLIILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNH3</accession>
    <name>W3VNH3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNH3"/>
    <dbReference type="HOGENOM" id="CLU_105945_0_3_1"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF28">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="78"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="187" mass="20771" checksum="1338EB77C25DBDFA" modified="2014-03-19" version="1">MGKDEGVDESNLFNIMLEQADDIDFSDPSKPRDQQVDPTELKVAGVEVSKLFCVVYWALLHSEDEEGITAGLDMMNMQQAKKAVHGTFLFNVRPAPESGAGNEVIQFYVDMRREGTIIRGPGPAKPKPDCILTINDRDMIRIALGQMSPQAAFMKGKVKVKGNIMLGLRMQTVLMNEVKKMSRVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNI0</accession>
    <name>W3VNI0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNI0"/>
    <dbReference type="HOGENOM" id="CLU_039076_2_1_1"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="173"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="505" mass="56842" checksum="619EA92498E35225" modified="2014-03-19" version="1">MQAWLIAFGVLTVYYWTVQLLRYKHYRHIHQRYGGRYAIDGEQASKGKPRMIDSYRGVRDAQRILRLAASMDHPFVFTKSLEFALFRTYGIPTISSLLLHTGQLGKADNAGRRYVDTAGLIQSFMTFPVPRLDLPDGGESSTAPADRQGWEHFGEDPDDPRSSIALARVNFLHGRWKSKISNDDLLYTLSVFIIEPAKWIDRYEWRKTSALEKEAMFALFYHIGRCMGIQNIPETREELIQWSLAYEENYMKFEQCNHEVAQHTTALLMYALPSMLHGFATHLVVSLMDERLRVAMGYPSAPAWVMSFKDTFFRLRALVVGSLMLPRSKPLANIPIGSDEAGKVFSVENLLSEGIPGVCPASGIRADEGKTCPVGGHLHAEKAAGGGFKPAAWRMELRWYENEPAYARPFEPWSAGWVAEEAKIALGLLRSEDRRGAQKWMPATLPVPQKLQQGKDAGKPIPGFGGFRLEEMGPKGLELKGRNEVLANAEKLHGGKLQGKWAFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNN8</accession>
    <name>W3VNN8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNN8"/>
    <dbReference type="HOGENOM" id="CLU_091428_0_1_1"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="26"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="203" mass="21905" checksum="F84954D42682B376" modified="2014-03-19" version="1">MSTTAPAHDPTAQGAHSKGHQHTPQEKIETLLDITKTVGTGMLTTRSPDGKLASRAMAPATTEGLVSSFYMNTDSGKTDDVETDPQVNVSYYDPKTTDWVSISGRAVLNRDPAKIKKHWSSSLKAWFDDKKDGKHTGDHNDPRVVLLDVQPDEIRIFKADGKLSALAQTAKAAISGHAASPGKLLILTSQEIQLAAGVYKPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP30</accession>
    <name>W3VP30_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP30"/>
    <dbReference type="HOGENOM" id="CLU_130569_3_0_1"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="121" mass="13570" checksum="C56DEB8A28EF390F" modified="2014-03-19" version="1">MAGYADLSSVKRQLTIKTGVVKRLAKEESSYMHEAREQQVRIQQFIDAGRDEYDLKQQRSVLKDSLKMVPDCRKRLELAVDDLAVYIDGVEGEAVSSDEYGAAKQVLELAQAQIQSPLPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP36</accession>
    <name>W3VP36_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP36"/>
    <dbReference type="HOGENOM" id="CLU_1138425_0_0_1"/>
    <dbReference type="OrthoDB" id="10515263at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="244" mass="25884" checksum="41C880A168416C60" modified="2014-03-19" version="1">MEWQQSIVDSGTRSGGKVEPVEPPPPTPPSAATLSNTCTEHAAAKGSDARTALSAPNSTAALPTKKLSVGRESRSLGILLLFHRLTKPFASSFGSSHTSARIIAAHQSTRIGRAEHIALRPSSKPRTAPALPSWHHIVPARFGVDTILDPNAQLAVSPSRLFADSQSHRLARLYTVPCIGSLGLVYSRVAQLPLIPLVPQRASASLPVDAYRFDAVPHAFLGIPVSSLSKRLPRGPNQGFAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP57</accession>
    <name>W3VP57_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP57"/>
    <dbReference type="HOGENOM" id="CLU_003690_4_1_1"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833425" description="Glycoside hydrolase family 92 protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="77"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="349"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="96838" checksum="C331D0AA19DD92BC" modified="2014-03-19" version="1">MKVTTRFLLATAVVWIDASTSRSAPLASNAVHEQSFQLPADAGSGLYARVTTPLSAGAPPSDAELKPHTDATNLTQYVNIFVGTEANDDPGDVFAGASVPYGMAKATINVEGYAPAGYVWPSDKPTRGVSPLHDSGTGSSSGSYGNFCIMPILCADNELDACTTLLEPRERMRRNGTDHGRPGYFTTTLDNGIRIELTSTRRSTLEKYTFPAAEMRRAKSNPHLVLDWTNDSPGTFRGGEMKADWQQGRLTMNGTWLSSFGPGDFRYQAFQCVDLLFQGKQRLSAHAFFGGNRRGYDTKRQDLDHWVRVAQQIGQYQAGALVRFDVDREAKEDVTIMVRRGVSFASAENACRNMEAEVGDWDFDATVASSEAAWEDKLRRIELSAATPDYIQRLFYTSMYRTFLSPNNATGDSPFATDSPYFDGMYCTWDTFRTLFPFLSLTSPHEFGEIVETYIDGWRKEGWLPECRANQVKGFVQGANHGVPVLADFAVKYAKAASSLGVDTDELYRAMQHDIDVPWPQWEYEGRQAAPYQLYGYIPFGYLDPASVGEQTREASRSLEYAFGDFTAAMTAQALGKPVEDVQRYAMASLNYSLNFDHGTMSDGFKTFVQRRRANGTFVPSDPTFCSPLDNNSSHACSLQAENDFGVYESSSWEYSFYAPHDRAGLVELMGGNATFEKRLDHFFSKGYFAPGNEPSFDTPTLYHVLGKPYRSVRRVREVVDTYFSLKPGGIPGNDDNAAMASLLGFYLLGFYPTPGTKELLILSPFMPGYTLHNPVLGKATVNVVGYDERSIGKTIPQGVKAFVSEVRIDGKRHTSRCRLSFDDLFPGTPEGERKVEIVLTEQEMEGCGDTDGDWPMSLSTGGFLDLKGTRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP90</accession>
    <name>W3VP90_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-arabinitol 2-dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP90"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="37840" checksum="46E238BF31E4BCE5" modified="2014-03-19" version="1">MLAPTARLAARTSARPSAVARAFASSSRSMSQDNKGKAKPLDTAPFASTKDDVVVPYPEDSSRHPADDVGHNTTGGRVGRHTQRTLASFSMEGKVCVVTGAARGIGNLIARTFVESGANHVAIVDLNEDECQHAAREVEEWFTQHGGVKPGELDIQGYGCDISDEAQVQDVIGRIHKRFGKIHVAVNSAGIVENYPATEYPTPKLKKLFDININGSYFVAREVAKCMMQDQTKGSIVMIASMSGSVVNVPQAQAPYNASKAAVKHLASSMAVEWAKAGIRVNSLSPGYMLTSLSRAVLENSPNGKELRTTWENLTPMGRLGDPEDLKGAVVYLASDASAFTTGSDLIVDGGYTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPD2</accession>
    <name>W3VPD2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01692</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPD2"/>
    <dbReference type="HOGENOM" id="CLU_013430_12_0_1"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="295"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="438"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="617" mass="64417" checksum="544834DE74B7723F" modified="2014-03-19" version="1">MRLSSRSRSFLTTTTAGKPLRSTPLALAFIETRASTTRQPRKVVASSTARPQPPVVYARFKSTHHPAHPTAVPTSPVLPKPSHIASTLATEEARPPTAHPQPPPHQGPPRLVRYEADSHAHPQHPLALYPSSYSHASYPDPASYRAHLSNRRAPASLFGLFPSTSITAASVKASSDPHAYPGAGPTIQTSITTPTQATSKPVAIDSTAPSDAMTASASSIVDATKSGQAELHQRKKGAAAPASATAAAVATSKHSHSHGHHGHHHGHDHGSPEEADKLLAALKGKGDRGSNITLAGLVSNVGLCGAKGVAGVYLNSAALLADAAHSLSDMFADLVTLFCWKMSQKPPSASHPLGYGKYETMGSLGVSLVLVAGAVGIGFHSYGLLLEAIQPTLQHAPAAIQALSHFTGSIASAGGLLHDHHDHGAVAHGEGGVLDPNAMWFALLSIAVKEWLYHATLKIAREENSSVLEANALHHRSDSLSSAVTFLAIGGSWLGFPVLDPLGGLLVAGLIGKQGADLLIGALGELSDRGVEPEILQTLDQAIVEVQKQNPLLLGWKDLRAVKSGVSTFADVTLQLPNDATLHTASHIEAQVRAKITAAVKGVKEVRVRLVTVDATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPF7</accession>
    <name>W3VPF7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPF7"/>
    <dbReference type="HOGENOM" id="CLU_013444_1_1_1"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF56">
        <property type="entry name" value="GALACTOSE OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="1">
        <location>
            <begin position="293"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="383" mass="40364" checksum="A399A3FC149BCDC8" modified="2014-03-19" version="1">MTGASYSAPNTVAKDGLWSKHQTAYMSWDLNANTQTEFVVASTQHDQFCPGLNALADGRLNINGGNTDRATTMEFTIGGSFTGGIGGTEVPLKDGEVYDPASNIWSALPSAKPGPRKQLKWYSNSGQGGARGAGTRNAINDQMCGVTVMYDNGVIFSAGGSQSYSDSDGLTATHKITIKGVNTAPAVQTDVRQCGGSAQRPGVHRWRLDVCNAYTLVALIAVPHNYHSTLLLMPDGRVMSGGGGLCYVGGNCQGTNHPDMQFYSPSYLFDASGNAAARSQITKLASSQQNGDQIRVYPGDTLTVTLNSASGLGHVLIRMGSSTHSVNTDQRRITRTVHLTSGNTVTLRLPSDTGDVTPGFCYYLAVASSGAHSIGQTVNVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPI4</accession>
    <name>W3VPI4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPI4"/>
    <dbReference type="HOGENOM" id="CLU_2278647_0_0_1"/>
    <dbReference type="OrthoDB" id="10346206at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="102" mass="10814" checksum="769DDCDF02461816" modified="2014-03-19" version="1">MPPGNLVRRLVRNKLASVAALRVGWNCLTTNDLALSPLQDLSMAAGPQVSLPILLCSYDCMQSVAAAAAAPRLSPLSSEPDAPSLASLGSTMAYLRQRHVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPL5</accession>
    <name>W3VPL5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPL5"/>
    <dbReference type="HOGENOM" id="CLU_009583_22_0_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03814">
        <property type="entry name" value="GT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="4">
        <location>
            <begin position="43"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="340"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="651" mass="70653" checksum="BDA0E76E2173F1A4" modified="2014-03-19" version="1">MAVAAQRPIELMGVDDAVRAYPRDVKRPKLRVAIVTENFLPKVDGVTRTLARLLEHLNNEGHEAMVLGPETGIRQYAGHPVVGTFGVPLVVYPGLKLNFMRPRFVRRLQQFQPDVIHFVDPIWLGAQMLPAVHKWLPEVPCVSSYHTNLPTYATLFGMPWLEKTMWRLTRNLHDRCEIVFCPSESTRRMLQDKGFGNVEIWSRGVDTELFGPHARDENLRESWGCTPKPANLRLPLSPSVAAADAAAHFGCEHAALSHLAGKLGVSIVHPKGRSGSEDESFIRTPPTAAASPEVSFSPPPAYDSLSGVPDLPAGGFLLPPPALPAGAAAAIPAALRVEADAGESKSVVLYVGRISWEKNLRLLIEAFKLLPTSVRARAKLVFVGDGPARAELTRLCNRLELDAAFMGHQKGSRLAAMYASASIFAFPSFTETFGQVVLEALASGLPVVGLHAEGTSDLVSHGRTGLLLDVNAVAKASTTSAGRPIAAVRSNSASALGEFATAASSAAMKLPSSPSSSARGGKVEVGLASAIPSTLEFKASMTPNTPWFHQCAKSYSMLLERLILDRETRARMGQRAVLAASRKTWWDAMDAPVRGYERAIQNSGRNNLSDDELEAWRQKQRSNAPLTGPRVKLAIALYVALFAWLVWLRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPM1</accession>
    <name>W3VPM1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02449</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPM1"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="31"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="575" mass="62015" checksum="535A2963F5BDABDF" modified="2014-03-19" version="1">MGGVAVSSSPNGVSVGETKLLSKANVRPIFFCALAVVGAILYGYDGTYFTGILEMNRFKRDFGVLNDRGEYYIPSSDQSLYASIVQAGEVVGSLVAAPLGDYVGRRGGFFGACTLVTLGVVLQLVTIGSKALLTLGRGVLGAGVGVISNCTPLYLSEIAPTAIRGAIVSSWQLMLAIGQVIGACIAQGTKDIDSTWSYRIPIIFNLFFVAILVGAQFIIPESPRWLIQKNRDEKALAALKRVNKGQDDDIRDKVIALEYNSFRQARQDELELSGEGGWGTLFRGVELRKFVCVLGILIGQQIGGVQFIFSYTVTFMTAVGLKDAFIITIIVDVIEVVGVLCSFLIVNRFGRRPLILWTSVPMFIALFVVAGIGTKGLPPQGESLPHPGVITVTQGRTIAAMICIYVFFFNLAWGPLAWVVASELAVGKNRSKIMSVGTACFWVIAWAVTFTLPYLFYKAGLGAQIGWIYGVGTLIAMTFVYFYIPETFGRSLEEINEMLEAGVPTRKWTTYMTQSERLMIDQSRQTDDDSAASTNPTDLSPTASLGDDKKGVDAKGSGAASQESNPTRLGTSDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPS5</accession>
    <name>W3VPS5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPS5"/>
    <dbReference type="HOGENOM" id="CLU_399069_0_0_1"/>
    <dbReference type="OrthoDB" id="2556833at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="690" mass="75225" checksum="243CEEC9E19F156C" modified="2014-03-19" version="1">MDALASRAAPLIQSLQQKHGSTADAPGPPDFISAVSSARSIIFCLPLDFCCRRRTYSSPQHYPLRLTILRLVIAIEAPSSHNHVSFLMAPSMVSLQDPLKDSLVVAEGASEARAGRLPPRPSFFKIAKAKWVPLHIRLSNDRWVDMKLVSELDISITRAPEAEATKDPERCLSAIHQISYLTTVEPQLLRIRDALASEESAGQGSKAETSDHRILSRQSNSSDDTVDICPIDDSVDLSHRMSVDTVFSQASSFSDVTIAPALKSPFAAAFDEVALLCRTISTTPSLESESTDTSLGSPLSSPPIPPKRPPRLRRPPRATLATQQDAPMNLDRYGTFFTRFEPPASPIESTPGCSRGDSICLDPDLASEIAKKVMQAEQQNLEQASTVPVGTRRLDSPAASASLLFSDVTESKADGRYWINAASEHTHTSTSSLGTLRHSASRVSLASAFSNSSDEGCNTNGTYEAAMHRTRHAPRAQKGKTLISRAFKKFGTNRVVSDLGPSRSQDDLVDWSRSTRDMCSSPALSILSATSSPDIRSRRISSESDLSSAGPCSRASTPTQYSSPVFGRHRLAQQVAFEETEELMDDGVTATPRMAPDGHFDTMVDSHVHLPSYHRGLRKQIYPPRVRYELRDTPSPVASPQMQQQQLPSPHASPSQWTTKLAGIHSYSFEPVRAGSPRLDFAGPRRFGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPY2</accession>
    <name>W3VPY2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPY2"/>
    <dbReference type="HOGENOM" id="CLU_010092_0_0_1"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000161">
        <property type="entry name" value="Related to deubiquitinating enzyme ubh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="138"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="646"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="946"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1073" mass="111662" checksum="BA2C2655C7E79C83" modified="2014-03-19" version="1">MSFSWKGLLGVNQSSAPSSTSAPSAPGSHQASASPASHALPIGTPGSSVGGSVASPTSAGSSAMSPPSARAPLNSNPFAAAQPAAPAVPLFGGMIPSSNSFHSTSYIPSSSATTQSSVISRKPSEIPVNAAEGGGYLLGMENFGNTCYVNSMLQSLYFCRPFRDSVLSYNVAHRDRSESDPDHPRSHHDSVDSAAPTPLNSTSEPADGIPPADTLFAALRDLFEVIQQSGHQKSLSSPTRLTAPGSLPLSSPITPSPPSLGSADPPNVARRTSILGRPSTAGGIAGRGGAGNHIAANQAGSTAAAAAQAIPIAASSSAGAAPPTLSVSTSSTGTLALGFPAVDSNAVKAFLGTLKRENVLFDSTMHQDAHEMLNFVLNKVGEDLIDADKARTRVKMQSRNPYLNARSESDKTVDAHRRKNVMEVGPSGKTCVHRLFEGVLTNETRCLTCETITSRDECFLDLSIDIEQNSSVTSCLRQFSASEMLRSRNKFFCDSCSGLQEAEKRMKIKKLPNLLALHLKRFKYEETVQRYVKLAYRVVFPLELRLFNTSDDAEDPDRLYELCAIVVHIGAGPHHGHYIAVVKVGDRWVQFDDDVVTYIDEAEIAKYYGDRPGLGSAYVLFYQAVDLDFDGLGLVDPAIQATIQQKMATNGRTNGRGRAGSTTTEPIDARQHVPSPERAGGAALPNRSRLDSVTEGSPLVAGGAGGSGGAEAGQGANGWFGSFRNRDKRAGSQSKRRPKTTSSVDPLPAGATVVLASAASADPTKLGLGDVEGTTPDNASISTHSTSANEGVPRGITTASASITPSTELTGSAILPGSQAADGEADASPARHGAMTTTPASEVLSSRGTTESPSESKYSRMIGNQADAAANREAREQNLMRGIMNRRARAASEGFPSPGVLSEAAWGTTGPLLSHGQPMLGGGLVADPEEAAHAGHAAHTVVTPSAIDSGASPASTFPIASQREGPSGPSFAPLERLLSKKDAKTRNARRASSGYTPMSPGTEKKEGMLSNLFSSSSSTSSAAQSKRNSMQQMPAGSPSEGGAAAGDALPPSRKPSITTRTISKTFGFGRKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ68</accession>
    <name>W3VQ68_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prephenate dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ68"/>
    <dbReference type="HOGENOM" id="CLU_316196_0_0_1"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000391">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="481"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="909"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="147"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="950"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1016" mass="106801" checksum="A3030A430F763F91" modified="2014-03-19" version="1">MASFFAKARERAEAAAQQLQAHHAASSASKTGDTSNSSTTSGTGSSFYTGSVPHLLRHGIASVDPRYESTRQFHLLSQAVKGFNIDHEAAGREAKNLAKATFTWGQHHLPEKRDDSVGDEVLVDVTDRLAYVWHEIGQLETAHSQSAEQARNRLKRFEKAEMELGQRRAARNKLKKELHALVPERAMSAGSERAREAEKRLKDLIDDDQADEESLSRTKRESLKEGYSAMFDSLIELGEKMALVARYGKLMTTLIPTDKSPFPATVKPRGETIPLWEGAARTAEVRAALASALTSFRPDLSVPSLPSEAALSSGTSLGRADTVSYAVSHRAELQRDEAASDAATPATVASAAPASPRRSSLSLDRNDRLQPASADGNGSTQKLNLSPSTLPAPLLPPRPNRSPSAASDTLRSPQPDPFADPVAATSAAHPSVQDEEASGPPGPTVAETGVVPSGPGGPKSGTLRPRRASAGQRSASISAGAVAYLGPTGTYSHQAALKVFGETGTNLIPMQSITGAIDFVRRGTPGNAKIAIVPVENSTFGPVRDTLDNLLNISNGDRHAMRPSEGAQLHVVGEACLAVDHALLCGPRTYQRLLALQGDSDANAPIRDDTLSNITNVISHEQALGQCARYLTRYLPQARKKAVDSTAAAAITALEFEAGTAPGMASGESLGFSSNSLVVAVGAEAAVKTVGVRVLRSKIQDVQDNRTRFLVLASEPLPSLLATNSLPASLSRLYSASAQVGMVGRSLLGVHDAVSSDLVAESGSYSDSPSVLDRVVPELSKCTEVSIRKVDRRPASMVAASGASSVWRGSYVFELQYSAAAASTAEAKIRQVVTQLSVGSSAIRTVGDAAPVAYLGSWLVDGATLRGEPLLGAQSGAPLLATPQRISPGMTSSASAASGFSDLATPGHSGAVHLPASGSMSSDLSQSTLHAGAPMSERERKELEARQEAAEVQQHAAQARLVRQQQQAELYGVEPQPSGAGAARPQPLAGLQESEAEARLDEGLPAYQPFDPSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQA4</accession>
    <name>W3VQA4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQA4"/>
    <dbReference type="HOGENOM" id="CLU_043418_1_1_1"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="346" mass="39171" checksum="0ABCCE00DF50CAB1" modified="2014-03-19" version="1">MVVHVLDDFYLSIAFLISLGWQLLGFAIAFGLQIDTITDCWSAINVIFLAIFTLCCGDQYYARNVIATIFAILWGLRLGGFQLFRMFKMGGDTRFDEMRSKPLSFLGFWTFQLIWVWTISMPVNVLNSPESSNPANGGGNARFGNGKDVVGIIFFAVGFVVEALADVQKYRFKSVTKPPKGAITDAGVWKYSRRPNYFGEILLWWGVWLLAIGNSTEASPRGHDALYGSIFSPLITMALLLFLSGIPLAEKPTQQKYFLMSHGPDKNTEGLEPWRDQTETDAWQRMKAFRNRTSMLIPLPNGLYAKLPRWVKSTILFDFPFYNFDEAKDGSKAIREAEDKKNRDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQF5</accession>
    <name>W3VQF5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein MON2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001169_1_0_1"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="217"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1008"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="800"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1786" mass="193052" checksum="C6B5C7EC51D5064F" modified="2014-03-19" version="1">MAQLLTSELTSLGVEARRKHPEIKQAADAALARIKAEPDAFLSSSRSLGGPPSDHPLLRPVLLSCETKLPKVISLAMALLQRILLQKLLPDDAIPTVITALNKLLTPPSKSDVDVQLKILQIASALLTTYPNIHNADLSGTLMLGFKLHEGSKVAVVSSTAAATLRQSVMAVFDKVKDEDAVLDGIKGGGEEAAASAPLAAMSVDLPDGPVTLFPSSRDAYLVFSDLCSLANAEPASFLSLHTLSKTFSLELIESVLSNHQRLFSSLNTTQGQNVSHPELLFLLRSKVCPLLIKSLSEPPAFPIHLRLMRLLFLLLRQFSSDLVLEVEILLSILLRTVNPSAHEVAAHGGSQPTLWQQVLALEVVRSLCSDDVFLRNLWLWYDSGDAAADDSDSPRGSAPVFAKLVITLQSVLVQSENVFAMEPTMQDTTGADDTPDSPRRSRIRPSADRSFSGLYEAAAGVASAAMSQLTGSKGTESLSSASSPTVQIIDQLDKVEAPSVASAALPKTYLQLLALQSCHLLTQSMAAYALPLYSKFVNSRKSNAAPAPPAMHDTDIDTLGNSPERDGLRLTKAMLRRSALPLSDVLVRYLRIKCTDSIFEETLLAFHNLTNVAGALDLVQERDVLLTRAITFAVPRWNASSQSAVLNAMAGDPNLQAVSTRSLACLRAFLQVAYYLSGSLGAFWYPVLSGLCGAHALLSSRYPSVQASDDGEEDDGDVSRSGRATLSTLTHSSMTSLDTRSGRSQLQLLNLADLQPDRLQAQIQSIFDNSAALEDDAFLDFISSLCRLSDDMMQQSIQAAGTSAAESEAGSPRASGFRGRASISKNESASTFYPISCLDSVTALNTKRLCSLPSEQGWELVAKHLTKTLSSAALSPVWRSQASQAANKLAFGTMSEAAELSGRADKLRLEEQALRVISSAGILEGRRASLVDLEVRTTSVENLNKVMETFGHSLTCGWELVFDVCSATCKSDKRSAEGVSETSPAAQRAQLALVKAGFSCLQLVCSDFLSVLDLQQIQRCCSCLNDFGSQDMDVNVALTANGCLWGVTAEMAARAKARAASGKDAKVDAEAQPLWLFMLQCLLSISQSTRSEVRNGAISNLFRVLQQYGDMLESTAWQEIVETIILPLIKLLRASASDLESGTAEGLADQDRKAQLMGVQPSELKQWQESQCLALTQFGEVVRAYLASKLIHSPNFEGIWSRLLELTRTTFVAGPADLSQAAIKCFTSILSAPVQDGEQIGEADREIVQRAWRQAWNNWVTIGRHIRGQESKATDSSLGEDGKDKQARFTQKNLLAYIQAFPPIYRVLEGHFDYKEVETLLASLKGCVSYAQSPDNMSDRSSLTNVQEAARATARSVAGVKDVPALILSDLSECVCLAHAGGQAGGDQAKSGPTFVALSRTSITEAFGVFVSHEDDVAIYTGGAFESLISALVIPIKLKYDCPDCPAAGASAGRKDETQPMWQLALLTFCRILSRCCPKLNVRARKGELEREVVKRLWSKMIDGIGAAISADSSGALQLPRDVRDRDERFGLFLLGTIENFVLPYLGESEVPDYLIDRVGRALAFGSKLYSFEEEAPLEGQGGCADDVTEVVNERFGYWCLDLLFLGCSEGRGQSEVHRRLATALLKHLVPRCEQVLRSYARDLQIRGAVPMPRVRQEEINHILLRYTELRLLPNTLQSATGTHAWHSAKRTHLFSAFRLLLVLVSVSTASKVHASIGTSQPESVVTDTEALAKTFTDAGLQLGVVGTTRDVLGAKSTKRDEAEPSELAAEALALVADELGVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQM8</accession>
    <name>W3VQM8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQM8"/>
    <dbReference type="HOGENOM" id="CLU_000688_21_14_1"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="185"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="459" mass="49898" checksum="FFA67B1176411D3D" modified="2014-03-19" version="1">MTSLARHVFLHPSTYPSAIVVAKHTLQVEPADPRIRFIRLGRLPTHPASSPDPAATSRFASKFGKMKEVTRKMMTDVALFAMSQVAFYYAFKYVMSSLDPNRQKRQDTKKVADAKLGKLGLRGKDLELNEYEEQISAELILPEDIPVDFASIGGLDGIISSLQESVIAPLCYPELFANASGLLGAPKGVLLYGPPGTGKTMLAKALAKESGATFINMHVSTLTNKWFGESNKLVAALFSLARKLQPSIIFIDEIDSFLRERATGDHEVTGMMKAEFMTLWDGLTSSTDRIMVLGATNRPNDIDSAILRRLPKRYAVSLPSAAQREKILSIMLSATSLDPKFSMTELVKRTEGYSGSDLKELCRNAAMRPVREFLRSKAGRESVAERRRLAAAGVGSGVDNTPVGSLTPSEGEVVAAAAPTSKIESRPLRNSDFFVIDSAATPVNGSRSGPMAVDEDPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQN0</accession>
    <name>W3VQN0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQN0"/>
    <dbReference type="HOGENOM" id="CLU_002865_7_2_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="458"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="628" mass="67574" checksum="62DDBE2F75BAA80F" modified="2014-03-19" version="1">MGLFSAASPLKPDASTYATAANLPPSTVEEAHKAKSYDFIICGGGTAGCVIASRLSEDPNTSVLVLEAGGNNDALEVKAPLVFTKNFKTERDWDYTTTPQTEVRNREMQWPRGKLIGGSSSINAMMYHHCAPSDYDEWAEKFNCKGWSYKELQPYLRRSEKYTPHAFTPDVKAAERGDAGLWQTGHSSFKSEVTSKGFVNACVEVGIPYNPDLNTPRGTEGVTHFTTFIDSNGRRSSAATAYLPLEVQKRPNLTIGINVMVNRIIFDTTGAKPKAIAVEMQNKKGGQKYYAAANKRVVVCGGAINSPQTLMLSGIGPAATLKKHNIPVIVDNALVGERLSDHLCHTTINARAKPNHTLDYLGSDIKAIPSLARWLVTGGGPVSSNAGEAAAFVRCNDESLPLVTAQTKPENRPQFFGSLGKGPDIELICTPLAYNDHGALPAPAGTGCVSIVGLNVRPRSKGTISIQSADAWDKAVVDPKYFSDPDDNDRKVTLAGMRLAIAIAKANALQPYLEEYKSDDKDDFYWPISATDPSKLSDDELMDFMTKRAFTLYHPVGTVKMGPDASDSVVDTDLHVHGTEGLVVCDASIFPEQISGHPTAAVIACAEKAAELLKQVAKSGAQGIASHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQU5</accession>
    <name>W3VQU5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQU5"/>
    <dbReference type="HOGENOM" id="CLU_391872_0_0_1"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="493"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="704" mass="73775" checksum="6047481D2283A83D" modified="2014-03-19" version="1">MAAPRKLVLAGRRRKKDALVERANARFRVELSSSSKPRQGAALAAAKFSVEFLQKFPPDSAQRAHVMKTLEDPSALFAVPDNPLSAMGPINAPPSSFVKQRRRRMTPPGTRLRSLHAKQHRLLSTLSQGIRGRRGWDSDADALVAILNPCLFGASGPFSQPGLLKDLQVAPFLRATTTVAPAAMPEAMVAFFPDLKEHDAATRLASLVRRVALQKPKANGSERAGSLALGSCSCAVGAATGTHACRSASPPCIVLSAVEFEKRAAEASELLGSADLRQKRDAPPSTLGMGRGRLNQPRSRASALPNWPTAALHCTFRLGPLCLECWSQNICRSSAHQQRPDARLPASLIFLRRHTSTTPIPPPSSAQQRDQREMELLRSAPQRPPDEDSVHQHSHRRHSFDPAPANTRSTTPSPPSSFDFEQLHLNTLAFAFLTSTTMKFFSAAALAPWALFALSSVESASAVPGMVKRQSSSSSSSSAASAVSPLTPGLTNEGSPLLIQWDTTTNQAWKSMEIKFMTGSNQNMTELYTVATDVDGTSAGAGKLLWTAPNVEPNSGIYFFQFTHDGEDPTWTTRFAIADTTGAVTAPPNARQPEGPAIPWGVGRIVSAASAASSSSPSSASASGSAAANTASASSALTSSSSSASAGSSTSASTSSTSSSSNSAQTGNSSGSNSQTTSGSTSTRAGSAALVGCAVAAVAGSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQV4</accession>
    <name>W3VQV4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQV4"/>
    <dbReference type="HOGENOM" id="CLU_293031_0_0_1"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="810"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="935"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="850"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1055" mass="114200" checksum="57A45B65891E6DF1" modified="2014-03-19" version="1">MPQGPLINVGPTASLAAIPPRPPAFVLQEALVSKEARFDRHSASTDSPSPSMAANDRNAVGSPSYGPHTGSGASYTHQIHASPHRTKNEPSDSSPIKADASRRSSSPPQASSSKAGNARDDTKEDKKSQKRPREQYSCVECFRRKQKCDRRFPCNNCIKRRLPERCVPPASARASIGSGLATSPTPSESGTVHRNSISRTASDLNITTTPTAKRQRIDEDGWDDRKIDELARTTSRIARLERILALNDASYLEQRLALAEKAVRLRLGEESSSRAINDFGPNDQISRRSSYVPDESETDRHVDGHLDDNDGFLGTSALEAVPLQLKNGLPTNAKAGSGDVAPQALLSYIHPNPTRRGFPIPSADVQAIRATLPSRDQCERYFDAYFAHYNWARLPLHEATLRDRFRQFVAGVASPSDVRMDAETLPFVALVLAILTLGSVPPIVQPLSSATSHAFFWATKKALVLCETLGLASLDSCWAHGVLVRYLDVIRVTRASWHEIGSWIRDALDLGLHRDGSSFGLPKEQVAARRILWSHVIHNDREWSIILGRPLTITFYTTEMPTREDLEPLGFACQTYLLARNRLTACLEAITHCFEERSQSRGPSGRTSRAYYRVLEVEDMIAEFVDSLPPYLAPNWSSSGKAKTDTSLDQDHPLLPFYRYLILGEVCFYRSLLHRPYLLRPASHGKHPFPESRRVCVEAALNDLRLRKEYARVLSKEQLAQSFGGAYALFNSAIVVGMSLLIGFSLGERIDTADLNERIGYLQNFITQLRRNFDAGNVDASAEREQMVIEVLVSRLEPFLPRDLAKRSRGELAAAKGSMRATMMQDPMRRSHAASQRVEQEKQAVDSLRLLSTSVPGTPTMSNNGAGQLPPSSMQSMPPSHHLAGSPTPMGGPGFDSTAGAMGSMAMGGGAGAAAAGMGPGATANPIDPYGWLLTPTAMESPDTKTSSAGTSTAHTPVMSGTKLGGTPSATTGMGGGSAAPTAGTPVRHGHGHSLSGSHPAHFMAASPGQFASLSAPGNAAEGQAMFDWEGILQTIGSGWTGDGTLETGMESLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR96</accession>
    <name>W3VR96_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261085_0_0_1"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1306" mass="145488" checksum="8484A0EA94C6B0B0" modified="2014-03-19" version="1">MSTCAGPEKRPGRIACIQLDSKHADVPRNIETALRLGAGLIADRFADPVDLVVLPELALTGYVFESREELDPLLEDSSTFSPPRPISGPALSSDAAAFISACRSSCVASDHPSLNLAAHVAQQLQCHVVIGFPERGSPDHDQAIRATAAGATAVSAPYDARPIEHRAEPTAIEARAAYNSAALMAPDGSLLHVFRKHFLFETDEKWAVQGSGFQTLRLPALGTVCVAICMDLNPFRFTAPFEAYELASFCVEHDVDLLVMPMAWLAPSDERHQLESDQAAAPPQPSLSTINYRRCVANLSFNRPSPRAIRRASSTPFSERRRRQEHSAMRLPSLLKLGSAAVLATLCFLPHSSTAVGEEAGPSSVPSWVERARPRVEDYITLLHPHRIALLRHDAQLHPNMDSYQYLPFIDGYPLFTTRTDPETAEMALSYYDRVGILDTARHDGRLIKYGNARLEQDLLPDLDRALNLHSLDSKVHRLRHLVLRGGIAVPPRPDILSLPHVRGVPVLTAEFSTLDQMLHAAGTGNGDFWYLRSSAPIVKINPREEGLFELATARDLREIERVSSGVRHARLRYGDSLSSLLWGAPVELRDLHRQDRIRRPSLAHYPRLVDSESRDEMINALQTRGRFRLYRSGQHAGERFKVMLINPDAQQGTHMRIEVRPLTDWERTQEDCAAPADTSKGKEIVDEGAGPSSPVPSGSGSPVLSHRPVSELQLLDPPPDPFDPTPLSFDDIVDGRYVPTPITSTHISQLTEAENDATTLLLADDTRHSAGPIVDLTNPRSYRSFNALVHRYRMVDLYRILPDGSIDARSLFFSPRAKKLLSITKGAPLIALHERISKIEHIRRNYGDNVAWARFHRPFTPVHRAIRESGVQVQPTWKDVLATGFFQTPIRGQAAEIRTYFDTHRIAKFISIDASCIAENNTKQLREEAASILLIPDVQWEADAMPVSISLISDVHREGFVMSGRYEGESCVGRWGVLTPASHDKPGPHNEKRKADPRPMLSRQMLYEVGRRLSQRVYTMHSYRLSTFLSIFLLGSIASIHALSSPRLKLEKRVNPDFASGTVPEHASGTVPGHEAEVLPEHLAGLLPESAGTSSDNVAGTISYQAIEAGFFRPHTRWTPLRTTSMRSLWYYSALFHKRVPIFFIGHDGFSKRELEQAYADFGGFHVMGRPELGQHTLTVSKGRYDIPLVRHATRSVHQHALNAYSTRSVFGDTAASVAFGYEAPPTHSLMRSNAALPSWNAVWEGMRAPENMVVRDAKRQLERDRHITFQSADGSNQLGVRLLNNGKKEIQWLIDTRPVFRQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRE0</accession>
    <name>W3VRE0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_02392</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRE0"/>
    <dbReference type="HOGENOM" id="CLU_005361_0_2_1"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000019">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="131"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS64055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="815" mass="85520" checksum="14A4FF492E105146" modified="2014-03-19" version="1">MASTPLNIPLESMLPAPAPLRVLILGSGGREHAIANHFLRSNRVEHVFCAPGNGGTATLGPRCTNIDSPKATGDFSDITAWAVQNQINLCFPGPEQPLVDGVELAFRKVGIPVFGPSPVAAQMEGSKTFAKAFMDKYNIPTAAFQSFDASQVDECLAYIQKLGGAQQVVLKASGLAAGKGVLLPESDQEAQDGVQDILVKKVFGDAGSSLLIEQRLVGPELSVLAFSDGYTVTALPGCQDHKRIGEGDTGPNTGGMGAYTPAPEGLVDDLPTRIRNEVLVPTIDGMRNEGFPFVGMLFVGLMLTADGPKVLEYNVRFGDPETEAVLELLDESKSSLADIVLACVERRLDAVKPVVRNQHAVSIVLASQGYPGKYPTGLPITIGAVPQNVTVYHAGTKLDASGQLVTAGGRVIAVSAFGNTLQEAVELAYQGVDAVQFEGKTFRRDIAHRALKPATSSSGGLTYAAAGVDIDAGNALVEAIKPLAKSTRRAGCDASLGGFGGTFDLKAIGMRDPVLVSGTDGVGTKLRVALDMGKHDTVGIDLVAMSVNDLLVQGAAPLYFLDYFACSKLSVPVASAVISGIAEGCRQAKCGLIGGETAEMPGMYIGDDYDLAGFAVGAVEREALLPVLDQLKAGDVLIGLHSSGVHSNGFSLVRKIVARSGLELSAPCPWSAEKDGSKPAATLGEALIAPTRIYVEALTPLFAEAKGLLALSHITGGGFTENIPRILAPGVGVEIDLASWQRPALFDWLQATGNVEPEEMARTFNNGIGMVLIVQQQEQQRILDLLSQAGERPVVMGSVVDREGVHYTNMNAWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRG8</accession>
    <name>W3VRG8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRG8"/>
    <dbReference type="HOGENOM" id="CLU_458686_0_0_1"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="146"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="606" mass="67814" checksum="32DAC687334BD6B6" modified="2014-03-19" version="1">MRDRARPRRAVELVQYVLSLLLGPTHVVTLRLLWLALLFYGERGVFHDAANRCQWPEQALPAGIDARPPVHILLVTDPQIIDRDTYPSLPFPTLLYPVVRHFSDNYLKNVWTSLAVNPNKWMMRENILPWQPRAQDRFRPSTTLAQPPDAVVWMGDLTDGGRRHRTEQEWAALVLRFRSIFWRPREADWEAPKATLGSTRHLIVPRTSANMYIPTFHLSGNHDIGLPGTSTSGRRIDVNAADDAIERFNRDFGMKIDGGGFVVKDRNPFLRSSLNGRILASTDVSLGATHELLLVNAQDLVGMQRQGGGPFDTYLAPAHQGEFDGALGEEAHRAYNETYEFVDSVKRGGFRVPRVLLTHVPLYRPEGAGCDDAARSVQHGVTREAARPLHQGTDRGSTYQNMVSESVSDWVLRSIDPAAVFSGDDHDHCEYRHRRPAGPVAEDGSVDGFALGEIPELTVKSVSMTEGVRRPGFARLSLFSPPESPTAGGEQQHATMAYTPCLLPDQIGIWTKLYLPAFVLSLVLLAVWPRWAHSRNSSGYLPLSNPRKRDDDDDDFVSGNTDSARRGVSVGSKRRTARRWGQDLMAVIAVALPFWIVCQTHLHFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRI2</accession>
    <name>W3VRI2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRI2"/>
    <dbReference type="HOGENOM" id="CLU_622754_0_0_1"/>
    <dbReference type="OrthoDB" id="2544456at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="440" mass="47500" checksum="270B2BF072274CBB" modified="2014-03-19" version="1">MQRVRRDEMGSDGRTRVDDTDPRISFAPSNSPFVTESSVWTIPKSPLAYNGSFVASDADDAKLSFPFSGDTLHVGMLHTAAGISARLTLENGTSLPLSITPQEAAASLPGNSTTAFQRKVLRFSDLGCSNHTATITPEPNTLAPIYFDFYSYKPPGPNGCSPPAPTAGGRGSVDEHTMLHAGIGAMAAITCVAVGVLVYFWTKRRKKPKVDEVDRMYKPRRAQTSVETMAMPLAGAYYGNKLSVEHEEYRPRGLHTLPVPATESGRSSTYTEEEAFNIGQTLLGLDHEASSHLDCKPGQENATTSALLSSHADGEEKSAATAPQSVRRPCTASAVDRLCSDARELAVTRALSPFQRRLPTAPAVPVAGRFRRNSTASVETHWTSASLDESRLDTTGMTIEHERGRVLSNATLPRRPPKSPHRPTTGTNPPPPLSYLPFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRP2</accession>
    <name>W3VRP2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRP2"/>
    <dbReference type="HOGENOM" id="CLU_038526_1_0_1"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001069">
        <property type="entry name" value="Related to GLE2-required for nuclear pore complex structure and function"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="51"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="281"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="395" mass="43296" checksum="73C2E8361980DD02" modified="2014-03-19" version="1">MAFFSSASTTNTFGARPAATPGQINTSAASKTTGDQDQEVTPGATDTVSALAFSPTADFLAVASWDNNVRIYQINKTSPTPVQPWQQYSHEGPVLDLCWSTDGSKVFSAGADKVCRMFDMNTNQPAVVAQHNDTIRSVRWLNVAGGVLLTAGWDKQLKIWKIDNPASPQAVHSLTLPEKCYAMDNVQNVVVVAMAERMVLGFRLEETGSITPLTEQQSPLKYQTRSMAVLPDGDGYALGGVEGRVGVQYFHDPPDKDNKVKKFAFKCHRRANADHPEVPRNESHIYPVNCIAFNVHGTFATGGADGSINFWCKQSRTRLKTMETKGPANAPKELLKTNPAKQPITAIGFNRDATIFAYAVGYDWHKGYQGAGQVEPKIYIQPVKYEDVQKRPPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS16</accession>
    <name>W3VS16_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS16"/>
    <dbReference type="HOGENOM" id="CLU_037990_1_1_1"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="4">
        <location>
            <begin position="62"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="279" mass="30085" checksum="9DC1A241ABE64352" modified="2014-03-19" version="1">MAETSKTTADQLVTDANKAFYALTAAEYDKMGRGMVVEVAKTNAANILARVPGIDASSTELMDFAAGTGLLATFVAPRCKSVTAVDQSEAMIDQLRQKLDAQQDAANRISNIMPVVTDILVDGESKIAGKQYDVITCTNSYHHLSDPARVTQVLASYLRPGGHLAVVDLIKTKDSAEFHTAPRTVEQHDGSHKQVDDFGAKTNEHSHAHGHGGHHHGHGHSHGHNHEHVIAHRGGFTQAEMETFFSGAGLKLVDMGKSAQFVKDGKSYDNFLAIARKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS99</accession>
    <name>W3VS99_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small-subunit processome Utp21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS99"/>
    <dbReference type="HOGENOM" id="CLU_002774_2_1_1"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="4">
        <location>
            <begin position="106"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="3">
        <location>
            <begin position="864"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1095" mass="118053" checksum="F95B9910A83B2D93" modified="2014-03-19" version="1">MPSKVATSNATPAKAKASAKPAVATPSKHAVDAEPNSKRRRQRATSDADVAAPSSSSSAPAAPQKIVSRNRLFAPFRALGLISNDVPFALQTRFGGKDATTPDVNVITCLGDSWAMWDAERMTLLFVSTSLPAPIASLVISLSPDAVLAAAGTKVYRFRRGKVDAVYDTVDHIMAAFDKPNGHMDEDDDDSSNSDSSSDADATEQQGTQLSSLLVFGDTIVALSSDGRHVFVWSVGTAELIRRIDLPDTFVASSILHPATYLNKILIGSVDGQLALWNIRTGSLVHAYDTEQLRLSAAGPNPSAPSAAIVNLTQSPAVDVIAVGFADGHVLLHDIRLDESLFAVHVAGGLSSGSVSFRSDGKQHSVAIATNTGNISIFDLEPSTASGPSSAQNGPRLIYSIQEAHDGAVGSIEFVPGQPLLISSGGDNSCKQWFFESASMPPRLLKARSGHHQPPHLIRYYGDEGKEILSAGRDRSIRSISVVRDSRSHELSQGELQKKSNQLSVSVSSLKLPAASSLSFSLTRSRDWDDVLTTHTGRQFANTWTVRDKRMGKKPLPASADRKIIAEARASCVSACGNFGLVGNSEGLVEMYNMQSYAHRRTFDTRPVDPLGATKAKEFPAGSKKAQAALNTRVKGSAVTGVVTDALNRVAVISTMDGQLSWFDFSSASLLHRIPISASGISSIQLHRDSNLLLVISDDLVLRLIDIETRRVVREFVGFRGRILDACFSNDARWVVATSMDAVIRTFDIPSSRLVDAIKMASIATSVAFSPTGDFLATAHVDSVGIYLWANKTQFSSVALQGLDELAEVVDEDEAVVALPTVQGDVEDAALAEYSEAMMQVGEPELQRVYTSPVQIDDASNDGGLVTLSTMPRARWMTLINLDTIKLRNKPKAAPQKPDAKRAPFFLPQTVSGVEFKFDPTAAVADDAEGETKADKSNIFSSAGISFKTEFQERLEAAADKNDVEGFFVYLETLSTPQLDVEIRSLTASDDLVAFLNMMLARLDQHRDYEAVQALLATLLRVHTDLILQTFNPEISDDGDEDDQMQLGADEDEAERLKSVLRKLIRAQVAEGRRLNGLLDQCLGTLAFLRGIPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSC9</accession>
    <name>W3VSC9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dipeptidyl aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_01263</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSC9"/>
    <dbReference type="MEROPS" id="S09.006"/>
    <dbReference type="HOGENOM" id="CLU_006105_0_0_1"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="16">
        <location>
            <begin position="312"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="15">
        <location>
            <begin position="841"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1046"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS64410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117773" checksum="E496CBE5723179EA" modified="2014-03-19" version="1">MVPRTSYDSQATASDATVEERDEKPYRDDASADDAPLYPPTRVSSRYHAHDELEDGLGGVRLDDDEQVGLMQADRDARKPHQGSRIWSQLRSSPQRSDKRRPTAFSGCLIFSGVVIGFMLALPLLQWLSSNTASAAPASTSVGTAKPSNNISSDASIESVHSWKQPASPNTPAGHYALANTQLFKVDFQDPGWETVAQAAAGTGLTEAEVTSFKTHDGHDLMPLDMDTVFSGTLAPQTSDLTWSEEDPDEGVFSHVDWTKRDIWLEDVTHARHQKTGSGKVAPFGGKVLVVEGKNVLDANGRMLTWTSFKLSPDLRWVLFFTEETDQWRYSKKSHLWLHDIAAKKTTQLGSGPKAPPKVTYAAWAPRSAGASTDEAPTIAFVEENNLFVVPRAGESAVKVTDDGAATIFNAVPDWVYEEEVFGTDSVMWFSPAGSKLVFLRLDETAVPVYEFPIYNPDLYRAGMTQAYQKMTRMKYPKPGFANPTVSVKMIDLDEIRSATRQGGAVRPTQYTLHSPMSSKGKAADEVDRLLSTDAGVKERLVTEVKWVSDSALLVKETDRYSDVMRIVHFDVARGMLPTMKAGSAGADVEGEVMRKQDARADKSGWIRAAQTIEPLSHHNLSVGSTAYLDIVVSPQGFRHLAYYDSATSDQPVFLTDGAWEIAALKHVDARRRRAYFVAARPTPALRNAYYVELPDWQASASSRTPATYTLKEPVPLTDVSKPGSYDVRFDPKGAYYVLDYQGPDVPYQKVVGVDDASFELMLEENVLLRQMSSQYVKPSSTFYQLVLNSTLADGSRAVASVQEIRPHDFDASGETKYPVLVRVYGGPDSQLVDARWARADWHQYVASTLGYIVVVVDARGTGFRGQAYRATVAGKLGDAEAHDVNEAAAAIATLPYVDEKRVGVWGWSYGGYLTAKSVELDKKVFSLAVSVAPVTSWAFYDSVYTERYMKSPHTNRKGYEASAVHVNSAFGKTKYLLMQGSADDNVHFSNSAHLLDMLTKAKIRGFRFRMFTDSAHSISVRGAYRELFEEMTSFIAELWGAGGRREPKGAKAKNRPALHNSVERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSD8</accession>
    <name>W3VSD8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSD8"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_13_1"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="115"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="673" mass="75167" checksum="74B23086A0EC8D49" modified="2014-03-19" version="1">MADNIQTEMTSVASSSQESAHQSSNSASSPSADGAHHSSSAAASSPHIDAALNETLFPSDSYTSDTKTYWADLPFWEKTSWINAQSNAEARRELGEIGRMFKRDPLSPIRAYFSNYVITGLGLFVEGYTLFSIGNLSPLFKAVWPQCWKNHTVCDENWLHAIDYLEIVGIIIGQILVGIEGDWIGRRFGMVQDALVMTLGSVMLTAMWGTSLNGWVICYAWSVFIYGIGVGGEYPMTSTRAMEGTGTGRAATTGDRMHRGRKVSLSFLMQGWGQLANQGVLIIGLLIFHGSLNGPYSETSTQWTFRVQFGIIAAFTLYLAYIRYYRMKYQDAALQTAKKRLNTSGYDLVSLKLSLHHYWHRLLGTAGGWFANDFFFYGNKIFSGVFISIITNNAGGLETTWVYNMYNIIISLVGYYMAALLIDHKQYGRKWMQANGFVADFILFIIGAALYNTLTVPGSGIKAFQAIYFLSSFFNQFGPNSTTFLLAAEVFPASIRATSHGVSAAVGKLGALAPAILYNYIDNHTKFWVVSWFGLLGWVLTMVFIPDTTGLDLREQERYWECVVQGREQDYHGVAVHPRHLSLYERVVLKRHRHYDPELDRQQKLQELEALFHSSKAEKGAAEDEVEGEMLEEDLQLYFQSLADSQAAGKKLQTPASSSAKHPSKLAEIEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSV6</accession>
    <name>W3VSV6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSV6"/>
    <dbReference type="HOGENOM" id="CLU_300379_0_0_1"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="143"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="349"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="829"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="871"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1003" mass="109323" checksum="9D523B831834CCF7" modified="2014-03-19" version="1">MSARKPRSDAARGGIDTFSSPCYTIPWQPKKKAKRASSKAALDGSSEPPFPVLAEFEADSDPAYVRYNSYCIAVQRTEALFERCMDLVYTPLFEDLKSFFHTDSGSSNPNAHPVLAGTAIANQDLFLPGFETLRSDNHGTVHQDGPSSSIQTALLISTSAPSLSSFSGRLVSEISDASNDGAQSIVVTLSASECSNLYTALRLVVARFIAQGSTIPARPASDAHATSLAEIEAAAFVGKVEPDLHVLAFWWSRKFGTSDRAPRLVVNLPMIESIEPTVLSDLLSSLQTFVAEPCRTASSSTDSAHSFASRPQLLLVLGITSPSGGLAAASASTSANAAATAAPAPWIEFIPRQVLRVLDISRFSLPSKEIVWSRLVQSFLTSRELPLSLGASTFEYIRETYWERDADLDAVLDAVRLACFMHFSGKPESVFTIPGEASKIRFFSWTPKMVERIKIAFLTTADSGDLVLPLLGASSGSSHLDVDEFLQEAARSDQFILGKLDQLHHPRDLLCYRIEFAIRFLSRAFEALQRIQNQANTAAQAMHARTLTLASQQAAEIDEQRQLERASEILTQVVMQCLNASVGSLEADHRPPAILTLRNGLARLCNAARRLLSDEFETLLDDMVGAAEDEARAIEDSVAESIDMADSDQPAPSRQLRTASEAIAAHSAKFLAGMRTFQQRLSQTLAAGSAGMEEDDDADVGAASASGSASAQAAKQRREARLQRVQRKLLMEEKLLGLKREITDWIVASVQELVDWRQIGRELSGLDNGPLHLLTDIFWVDCYGPLSTLLDPSTRAGVTLPLTAPGEFVESLYDAALSVVPEEELDDIDIEGLQSSQTPDVCRLYKLYGECGKFVNLADWFDAFKQTVQSDEATRTGKQDLAGEPPAKGSTANQGEANVDADEVDAPSTPSKRRSPSKRTVQLADADEYDPDLLDTPSRKRSRFAEPIQPDDEAEEGPASESDLQCRFALALNQLARMGMIRGTKRRNEHITKVLWDLVPDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSV7</accession>
    <name>W3VSV7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_01058</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSV7"/>
    <dbReference type="HOGENOM" id="CLU_011312_1_0_1"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="801"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS64590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="851" mass="96654" checksum="21C2E2FF30785C76" modified="2014-03-19" version="1">MKFYIDELPVLFPYPKIYPEQYAYMTDLKRTLDANGHCVLEMPSGTGKTVSLFSLIVSYQLFHPAKRKLIYCSRTVPEIEKALAELKRLMEYRARYNVPEGEESHVAKSDADGTNGPADDDIEMKGRGKAGGQMEDILALGLSSRKNLCIHPDVGRERKGKVVDARCRDMTSSWACEKGRQDPGSVQLCDFHEELGKMEPGQLIPQGVWTLEEVKEYARVKGICPYFAIRRMIPFVDIIVYSFHYLLDPKIAEQVSKEMSKDAIVVFDEAHNIDNVCIESLSIDLTRPMLDSAYRSINQLSERVDEIKRTDASKLQDEYARLVEGLQEQGEQREAESFMANPVLPDDLLQEAVPGNIRRAEHFVAFLKRFVEYLKTRMRVLHVVAETPASFLQHLKDITYIERKPLRFCAERLRMLVGTLELTRLDEYSALQKVAAFATLVATYDKGFLLILEPFETENATVPNPIFHFTCLDASLAIAPVFERFSSVIITSGTISPLDMYPKMLKFDAIVQESYAMTLTRQCFLPLVITRGSDQVAISSRFEVRNDPAVVRNYGSILIEYAKCVPDGIVAFFPSYLYMESIVAAWHDMGILDEVWKYKLIFIETPDAPETSIALENYRRACDNGRGAILLSVARGKVSEGIDFDHNYGRAVIMFGVPYQYTESRILKARLEFLRDNFRIRENDFLTFDAMRHAAQCVGRVLRGKTDYGLMVFADKRFARADKRNKLPKWIAQYIKETHSNLSTDMAIVESKLFIRSMAQPYPEGKNGVSLWELADIETRQAKERETFAKLMGGQLKVDANGEVVDRDDSDSDMEPAATKKDDDDDDFDAEFGGGDDLAHIEELDDPMMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT42</accession>
    <name>W3VT42_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase</fullName>
            <shortName evidence="5">UDG</shortName>
            <ecNumber evidence="5">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UNG1</name>
        <name evidence="9" type="ORF">PaG_00616</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT42"/>
    <dbReference type="HOGENOM" id="CLU_032162_5_0_1"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="8">
        <location>
            <begin position="188"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="417" mass="44348" checksum="2EBC763F79EA44B8" modified="2014-03-19" version="1">MTTRTSLAKRDANTLASSDNSIDHTSVKRARTDRDEFDSDDVDDDALLAAALEAESAASSQPAPSSSQSVPPTSGANHSSPPASPAGKITTAIATPHTSMRQTTLLTPSKAAPAATPATPALPKVQPPADDSDPLWLERQTMSPSWFDILRPEMDKPYFATLKSFLAAQDRAGKTTYPPRELIYSWSRLVPSPRHVRVVVVGQDPYHGPDQACGLSFSVPKGVRTPPSLKNIYKELAAEYPSFHAPNHGCLEGWARQGVLLLNACLTVSAGAAASHHGKGWEGLTKHILKRIADEAAKSRAAKAASANAVATSTIATMFAKAQSNPKPESKPVQPVQGDAEEQCRGVVFLVWGAPAAKTLAEAGVNDKSPNVLILKSAHPSPLSAHRGFLGNGHFKKANDWLAQRYGPDGTINWSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTJ7</accession>
    <name>W3VTJ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00394</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTJ7"/>
    <dbReference type="HOGENOM" id="CLU_008455_0_4_1"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="102"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="605" mass="65329" checksum="A28F2CBB601093DF" modified="2014-03-19" version="1">MVLKATSIHTNFLSNGEQYATDDAAAASTSAQQPESAAAAPAQRPSQSRKNSLWSRKSREQPRKDVEAPQGAKDDNIILVVWDGDNDPENPMNWSIGRKWLTTALLCSMCLFIGLATAAFSTGIGPMTEEFGVSTEVGQVGMLLFNGAFSIVPLFLGPLSEFVGRNPIYLGCYALFTVWFIPLALAKNIQTVLVARFLSGAFGAAGTTIIPGTLADIWKTKNRGLPVALFSLVAVAGTVGAPLYCGYILQEKGWRWIQWVQLIVNGAVVLLEFALLRETRGSVILARRAQKLRKETGDQRYRAPSDLEAPSLKALLHASTTRAALLLVSEPVVFCFSLYIAYAWALIFAFFSAIPIVFQEIHGWGVGNGGLAYIGPLIACFLAFGLSFHGKYLYDRAQTRNNGVAVPEARLYYAAVGGILATIGMFIFAFTSYEHVHWIGPEIALVPLVMGIYFIFEAIQNYLADAYGSEYGASAISAQGFVRNALAASFPLFSTQLFHNLTVPYAGLLLACLLALAVPLPFVLIKYGAQIRARSKYAASDDTEDGGPVIGARRGDVESKAMTSSTNSEDTTRAPTPTHGMDDSAKKLDEKSEVVTADGQPKQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTK8</accession>
    <name>W3VTK8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002285_1_0_1"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="182"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="260"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="394"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="763"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="925"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="664"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1233"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1341"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1396"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1472"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1559"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1249"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1358"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1373"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1427"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1563"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1595"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1622"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1645"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1660"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1695"/>
            <end position="1706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1754" mass="189051" checksum="7A7D1F8CDA7891ED" modified="2014-03-19" version="1">MVAPTLLDCWHVRDSQRFRALLKGSPPDKNNHNAQHVGANGSYGASASFSRSPHSFRDPSVPCPPAEVNRRDHYGRTVLHHIASCTEPGSIGYLNSLLAHPSVNINLQDGESGYTALHRALYAANLQTAIILLRRSDLDLRIKDFEGLTAFDLYNSTVAGTNPPADALSFEPARHHHERTLTQLFTWGSNRNYNLGLGDGDDRQLPDKITLRRQPAANSSSPEENFRASLPAGKKFDRIGIKDIAMSRLHTVVLTDEKVANVWVCGLGANGRLGRSPQTQTSFEPLKDFAETARSVAVAQDHTLIITASGAVYSFGLNRFAQLGYTIEQEFGIVASTTAKLGGGAGVTFGQPANTPQVELDIQISPRRIVGPLKKEFVLGAACSKLHSVVFTSEGLFTWGTNTGQLGYDRSGTAVQIQPRKVTALAAGSGIQQVAASDFGTACLMEGGDVFVWHNDTHFRINFPLARFSSSISVFRPRQVQPKALISKLSSSGNTFAALSDMGDLFTFNLEHPSEYSSTGTVGRAPAAGGSAAKSSAAQMAPKPQLLWSVRKKFTAVRDVAIGADGSVILCTESGHCFVRPRRSDTGGKGGGGKNFKFQQIPYLQRVVKVATSESGALAAIKADPGMRDVRVKGRTVEEALRDLLPHLKVQTLSEDVEKERGITSEVVEISDVRSEAGSESDSEEEPEDTPARAGSDAAKYVKMALLITEAAKRWVAGRQVSGPEADDMQTGSTKDTPAPAASTTTRREAFYGPHNLVPPFGCDAFLIAEGHYLPVHKLILGARIPNLRAALQNTKTKGSLPQGVKLNTVVGGNRIAVLTLSNCSFVSALFLLHYLYSDDLPPIWVPSIGLVIDKELKAAKIDRARIQAEMLSLAERLGLSSLAANIKASLPRQPEPTLREHMSQLFESFVDAEVAEAQHESSFSDVSLRFSDRTIPAHSVILRRSPFFAALFQPHWTAERWNGDNTITLDMSHMRWEVARIVLMHLYTDKGETIFDGCDEGRSLEQYMDFLAEVMAAANEMLLDKLKLVVSSLLRKRVLAHTVGAVMTEADFYRADQLKDITMDYCTKSMEALLEGGRLNELDNGMLRALTAYVRRKQDEKLHRTFNEDRVAALVEKHREFYDDLDIPPPSLHLIANTVRPKRAAPAGVKSPSLLPQDANRRRSNTRFGISNPASPDALRPLDSIAQRTAADDSGEMFAMDDENLSTPRKEASVRTQGSPWAVLPQVAHLSLDDTVDKGTPARPWKSRTVEAERRHATPDVPGSPASRPSDAPTDLRSIMAKEQQRQHQQSALPHLSNATTPSGSGTSTPVQRAAAPGFELSPVNIASTRLSQKERKRLQLQQEATASAVAVPAQPRSVSSSSPWNRATTGSSPADKSAASSPWSLKAAATTAMALSTSHEGSPAAAFSPSGRRPSAAPVQPGSGPRPSLSEASASPAANMGPTYTPMRMEAKSTPKRMMSNEAAWSTPTVVPARGSFGTSPSRPAAPLASREPASNTQRSLLGASRPSLDATAERATLPASPAQLTFAQIQEQQRLAIEAEQETIKQAAAARRSFLDIQEEERQAEERRREEQKQAAEFEKWFAEESRRVQKQTKASKSGTNGTASANAGKGKAQKKPTSKQQPQQQGSRAQTDAKASESKAPGGGKKGGAGAGKGKQSNPTESASTQEQGEGPKADRRAGKQRSGSVSQRKPAADKPPPKNADRNGGQNGRTPGSDAGKPLQPPPQHLPAKPSNADPSLSAAAPTFTPRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTN1</accession>
    <name>W3VTN1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTN1"/>
    <dbReference type="HOGENOM" id="CLU_1289428_0_0_1"/>
    <dbReference type="OrthoDB" id="10428895at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="214" mass="24095" checksum="B06D26A30CCF6F70" modified="2014-03-19" version="1">MIRYRNDGHVTLGPFNSIVNLELDLTGDDDEPHPKEGSQRKPTQRFASCPSSFGLARVTTGAVPKRTINFLTWQVPQIQYTAANAGRFESLAFVELRDERNNESFVYTFRLSRYILSIASNLFSVCRLPRTFCSRKLQHASKISLYESLSVMHYERKFVQHERAALGEVMVEYSERTVQGWGVFMADGSAHCHAEATTGTALRGQAAIASRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU52</accession>
    <name>W3VU52_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001524_0_0_1"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000004">
        <property type="entry name" value="DNA polymerase subunit gamma-1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="4">
        <location>
            <begin position="1103"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="935"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1422"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1487"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1548"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1426"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1518"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1560"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1572"/>
            <end position="1581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1914" mass="211701" checksum="11DF277AB6D150F7" modified="2014-03-19" version="1">MTISSMLRTSSRTASSWARALVSAHPTAQLKPHSVSRLCSQQRRWHAATPVDHPAANHTSKPPPPPPIAKQSSVTRKTDAKASGSVPPEIPRNEVGVQLLPRRLHEQLFPPTMDPVPPIAPKALNICRDHLRQHGLKASDASTLPQTAFDLPPLQGKDLAEHFWTIGREVAQPWLSMATRLSLIKPTNPPEELEETSSAKPAAEDFRFEAPEWLELDPALRTSGHLKPVTWSIEPGWTKYPVLRSKDNSAVALGPGVSVAHPDPEDDMLVFDVETMVQEGPFPVMATAASPNAWYSWLSPWLVGRGDGHERKDHLIPLGPSSKDDPPRLVVGHNVSYDRARTLEEYTLELGSTRWLDTMSLHVATRGISSPQRPAWMKHNKAKAEKRAKKLLEQAALKEETRRAIENALSGLEYDSDQLEGLKLEALAMDAEQVSPSTGPTESAAVDSSGATASPSTLDMPFSDDESGGLASRVSQPSSSESQWLEETSKNSLADVARLHRIPMKVSKSARNVFVDGASRQEILQDVQHLLSYCASDVTVTHEIFRRTWPDFVARCPHPATMAGVFGLGSTFLPVDDEWIDYQHRCDEQFNRINDQVQKCLVELAEKLRDEGTRDVPWSRAAKIAEERQMMTDQERLEPVFPDPNRARAWWEDDAWYSQLDWTPKKPKKAKASDGSDADAPRSDFSLPTWFRDGVLRNKTKDGFGPKSVTAQQLLRLRIDGKAVLRSESRGWMLEDGTPLVGSNLFAATALKKYGDQMTSGAGPTGEAILSAILSRDASLSDETAAQLRTLAESIKDLSEAEIQADAQLAQLDWSLKDIRLEEVRELQRNKQTSPETDGEGDGALASIAEPAWWPKWYWDLYKSATGELQVTIRSSIAPVLLKISWRGCPLYRSREHGWVFRHDPANQELMTRQTPLAFGMAADGLVQHLAAPVDVKGSKNKKGKPKGKGASKASSMPALVVKAYGNSIFYKVPHSEGEEANVGSPFAKSFIAYFEDGTLQSQHPDEVGRAAAKTALDLNAQCSYWIAVRDRVHKQMVVWNGQAGTAMKYPEGASGARQDKAGEAARRKGLILPQVVSMGTVTRRAIENTWLTASNAKKNRVGSELKAMVKAPPGYSLVGADVDSEELWICSVMGDAQFGIHGATAVGWMTLEGTKALGTDLHSKTASILGTSRNQAKVFNYSRIYGAGIKHATHLLLKANPSVTNEDATQKAKELYMATKGQNTHSDELFGAKFWFGGTESFVFNKLESIALSDNPKTPALDCGVTTALTKKFLGKVDFGNGRMSEEYMPSRINWVVQSSGVDYLHLLITAMEWLTKRYSIDARFMLSVHDEVRYLVKDEDRYRAALALQIANIWTRAMFAFKLQMDDLPLGCAFFAQVDIDKVLRKEADDPCVTPSHPDAIPVGVALDIEKILEETKGSLLPDGTSSLRDGSERSSIPATHAESSPSYVPSTQVHRSLGERGLYFLQAQASKELAEIRALEARAKMTEQSPERSATPVRIPRTRATAPEKTRSGIASTTAASRRSRSTSAAFDRDDWIKTCAEDAAAEAKKPARRRTGSGSQASSVRSTGGARPAAAGAKRSISAHTVPIKSGFCTFVPARREAATSEAQSVDAEHEFDAFSLSMFLPKRRVKKRTPFFREASHRQSVLWQLYRPLLQRCPSTHPELLREIKRVMRKNKAMTSEVKTADQMRRAHELLEVLTLAQNGDATAKSTLAAREEKLAQRRHEQSWNEFWEAKLHAKKFPKRIAHHSGALLPPTIFNPPLPRYKPVQPTAVSVMIYRRRVARLRRSERRMEVNELLAAAHMERRVLKLAWQGTSAAQASEAYDGPGFEDALTTQAAMIVEGFERDAARAALTFDRKTLVLAKRARLAKKRVHLARRHAAAVKKRLGKKAASSDAKAEEEAKKWRFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU53</accession>
    <name>W3VU53_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU53"/>
    <dbReference type="HOGENOM" id="CLU_043978_0_0_1"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="127"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="214"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="285" mass="31260" checksum="603DFB7CA1E6CE52" modified="2014-03-19" version="1">MLEARLREAVLLKKVLDAVRELITDANFECSEDGIRLQAMDNSHVALSAIELRSDCFEEFRCDRPMSIGVSLASLGKILKGANNDDVLSLKKSDDGDTLQMTFESPKSDRVGEFEMKLMDIDSEHLGIPDTQYDAVVKMSSGEFGRICRDLANIGESVKIEVSKEGVSFSAEGEIGAARMTLKQGSASAALADDDDDDEDVKPAKKKRKQDGASTGGQVPVKIEMQQAVNLTFSLKYLSNFAKAAPLADEVQLHMSNEVPLLCEFGFENGYVRFYLAPKLSEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU88</accession>
    <name>W3VU88_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU88"/>
    <dbReference type="HOGENOM" id="CLU_370955_0_0_1"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000207">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="6">
        <location>
            <begin position="462"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="692" mass="72784" checksum="48777E9F6BCA6CF7" modified="2014-03-19" version="1">MSSQQAPLAYAVAQWLQQSADSASVEHKAKLQHAAKSVSEAFGVDTSSAQQQAQYGSGPGLQAIFDIFLKTQAKMGGAAPASAAAPAASTSTAAATPSEADLAKAEQLKADGNKAMSAKDYGAAIEAYGKAIELNPNSPVYFSNRAAAFSQIGQHDQAIDDAKQASKIDPKFGKAYSRLGHALFSSGRFEEAVEAYQQGVEVDPTNEVLKKGLAASKEQVSSSSSSAPSSSAAGSSTRDAVSPPAGADAGAGGFPDFGGGAGGMPDLAAMMNNPMIAQMAQNLMSNPDSLASLMNNPMLRQAAERFGSGGGMPDMSSMMNDPALRDMARNFMGGAGGGAGRGNGGGNGNNNNNIVSPTVRVIYFASVRTTLGLSHESIALPSVPTSLSTLIELIAQRHNEKHPASVLAGCRWSVDNTLIEIDEIANWTLNGGEEVEPARKPLVTASVLSRFSAYHFAPAPSGVDSNLLILLHGLGDSDAPFFTLGQSLQRTLPQTAVLTLQAPHGVPFLDPGRHWMWYPTFDQFGEMLTKPNPRPTVDHLKGLLEHLTGACGWSASHIHFFGFGQGATTALESLVDWTKSHADEPLARLGSVVSVSGELISHPTLTKPSATPVLHIYRSPSEVPRDASRWASFRKATSALQLHRLALAPGGADEAMLRGQEWDGVMQFWSRLLRSRSSWELSGDVVPLAPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUH0</accession>
    <name>W3VUH0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF3955 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUH0"/>
    <dbReference type="HOGENOM" id="CLU_026578_1_0_1"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="7">
        <location>
            <begin position="96"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="595" mass="63803" checksum="0F9A9634F7F7F2F5" modified="2014-03-19" version="1">MSLCNTIPLPLSSHHHTLPTGPNSGASRLPHQAATSASCIELSRLAFPLLISGGFSELSFSLMVDTTPTRYYVDEPIARASPDETQSHRRRKSYVQGLLLLLIVVVLWTASNFLTNALLTTGGYDKPFFVTYANTSSFALYLVPYLVSSRLRKRWSNAEQHYAQLHQDDAEVGAPDAAIEDDKQLPKWLKTLGFDVPTVEPTEPALVKPLAVLANEPQLRGRASTATLRQKPIRLTRSFSTEDSSTASTPLLTPTPPVSRPSSPVRPFLVSTAVPRPSSIDGRRPRTSISIVRPSADATEAAALPLPPLTLRQTAVLASQFTLVWFGANWAINAGLGLTSVASGTTIGSASGFFTLALGAALGVDRFTLARLGAVCISALGVAAVTFADRETATATGMVKRSAVERGPPNAPMGDMLALLSAFLYSLYVMLLKTRIGSEDRISMPLMFGIVGAINICALWPVLPLLHYSGVEEFELPPSAHIWAGVVVNMAITFVSDFIYLLAMLKSSPLITTLGLSLTIPLAVVIDALKGSHTGGKVAVLGSAAVLSSFAFIGWDDHRTFKEEKREALARLAQQSAERDGDEALSIRSDTTEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUQ3</accession>
    <name>W3VUQ3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUQ3"/>
    <dbReference type="HOGENOM" id="CLU_2251208_0_0_1"/>
    <dbReference type="OrthoDB" id="10530435at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="104" mass="11081" checksum="2B1A15687373FB09" modified="2014-03-19" version="1">MRTSTPTSTVTASEKREGKVRRPIVPGPVAPMLMLLNSEISDRGFQDPRAPVPVARVSMAKGSMGRRRAAAKVRARPTDPSRSVALERSSGLSNSRSPVATLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUU9</accession>
    <name>W3VUU9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUU9"/>
    <dbReference type="HOGENOM" id="CLU_000960_27_0_1"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF10">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="626"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="672" mass="70115" checksum="6933D7CA601808EA" modified="2014-03-19" version="1">MQRSSSLSELRHSAFSSKKLARMLSPPKISSLSRIILSLTAISGVTVLNSFLGGALTVALPSIAKSIGLSQELLSWPLSMFSLVSGALLLIAGAMADAFGRRRVFLLGVAVFAAVSIATSFMQSGTGLIGCCAGLGLAAAMLIPAGVGILGSSIPEGPIKNRSFALIGAAQPIGFILGLILGGLLANNWRIIFWILGAFAIGLGACAYVSLPNEGEELIPTAANSRATSVLHLPTNAATVSVEGRASTTSVPHNLDELAASAGSAHGGSDSTSRSMRLKTFDWFGAFMSTSGLVMLTFALADAESAPHGWKTSYVLALLPTSVALLAAFISWERYLERRQRTYETGASVAATKHQTRNATFFKAPPTTPLLPPAIWRAPRFGAVLLVIFLAWLSFNVMSYLSTLVFQEVQHVSATKTSLFFLPMVGMGLALNVLAGAVVGRVPAVWLIVGGATAGAAACLILSVAVEPSTPYYKAMLYVLILQVGPDVFFPAGSLYSSKSVGRQHQALAGSLFNTTIRVATSLGLAISSTISTSVTKAAVSSAQSHTTLLLSRGLSLHPSMLLTGSSLVKRAAGAAVDAGGSETVPVEALLKGYKAASWFCFACSVLSIIVALARLRSIGIVGGMEGKSEDSSVNPTRPNSPQLPQDDSAYELKTIVEPRDRKASTSALPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV52</accession>
    <name>W3VV52_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV52"/>
    <dbReference type="HOGENOM" id="CLU_553332_0_0_1"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="417"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="493" mass="52954" checksum="CA8CB525409E4A5F" modified="2014-03-19" version="1">MPFIYLRCYSAGVASATDRAEAVAARAQQCDETSCATVADDYNAATLFHPPTSPLQKIERLKWLILSLDGICGERVVVESRARYGDDQATPSGRTLAFEPALQAAVLVPDSALEAGHCGEVPAVSSAVCRAAQIQSSGPDAQSGERGCAQIGLGGHRHLDYRFPTILHRSARPSAHSIHLRILASHRIASALVATPLDIMVAPTASGSSLARQVGGMLLSSSRVATTSALPRYAFSLSVRHSHVGSAPLDLPTSTSIEILPFPPHPNPSRPLLPSLRHARSALVKGPKGEVVVPLHECVTLLNASKPVAVGSTLESARITLSIKDDSSKKQRGTWGLTRSLLHNALVGVSEGHTVSLKLVGVGYRASIEPDPLPRTSKLDIALASSKSFFLSEAAKQAEVERAERIKQEAEKQGPNQRLHIRLGYSHPVLIPVPYGVQVQIPQPNRIVIKGADREQLGLFASQIRSWRKPEPYKGKGIFVDDETIRLKTAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVF6</accession>
    <name>W3VVF6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVF6"/>
    <dbReference type="HOGENOM" id="CLU_2360623_0_0_1"/>
    <dbReference type="OrthoDB" id="10524490at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="96" mass="10244" checksum="D43457DB968B8E0C" modified="2014-03-19" version="1">MSGNAALDTSTPNAPSLPPRLAVLTLVDSGQRITSAPITTPVGPALAIVAVLLFPRSASLRLRFVTQFVRRATLDHRRTRPLLVPVAPTQQLVVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVI2</accession>
    <name>W3VVI2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVI2"/>
    <dbReference type="HOGENOM" id="CLU_037966_1_0_1"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834594" description="ribonuclease T2" evidence="6">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="265" mass="29148" checksum="933D4B2B30DEB547" modified="2014-03-19" version="1">MHVQTLALLAAAALARAASMQAPFSLASALDTCLSCATLPTCPTDPCTTNTPGGLLLLTQFWDFHPAIGPSDSWTIHGLWADKCLGGYDADCDSSRNNNNIAAALRSSSDPRAAKALDTMNQYWLALNGNDAQLWSHEWNKHGTCVSTLNPECYPKSAFSEHQDIVDFFSTTTDLFDKYNVFKALEEAGIKPDVNARYSLQQLKDAVRQKWGKEASFRCRSGALNEAWIYFHTAGRSTSADTFVQVDPLTGDNRCPTQNIRYLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVY6</accession>
    <name>W3VVY6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclear pore membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002415_0_0_1"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="4">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="6">
        <location>
            <begin position="238"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="734"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="946"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="7">
        <location>
            <begin position="1310"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1510" mass="163110" checksum="58BE2C5B560B07F9" modified="2014-03-19" version="1">MSDTKSAPPPQKAAAPAAPAALAPSPPSASTVQPLIAFSTIDAPSQRFYAVGTAVLIQAWKYSRILRHLLSSSSSTFTPTFTSTSTAPSLSTALLINFALLFVLSRLGIPLLDPRLASSTSQPPPSSATQKPILQPAKLAGLTYIHYVLIFVALSFADATLIGSASTNPLALALNAILAVLQILTSTLGLNLPVTGLLPDALSRQVSINEGHVRIRDLIQPKSHILGQHTIHILPHSTAKLLPSSACYCVGPSTPQVTVPVLFSNAQPDLLQYSITDFASGHSTYFNVSVDSLIPFGSSLDNADSAQLDAISAAASSQSNRQNRAQRDLLDDEDALDDTSSLFRGLSYAERAKIRAQRRASSLDTPKSKRISSPSTRNAQQLLWHLPITQPGRIRLERVLDKSRNDARISTAEALVVQCPSAKLIPPASSAPSAATDPIALQHKCPGDRADFAAQVTGVAPLELEYRRVFEPVLPAGASGRQRDSSRNEFKRKISRISPPHHTSPLLLPEAEALLSPTDRLELARERTRAASRRNDAGTEDFSWAVSVDVDMPLSTIDLDLPGNYTYALESVTDACGNRVSVHSEPHHPLSLAQKARKKIKGADDSTALLHQSVVVHPRRTVAFDPRQCRPGHPLPLLRNAKGIELTVQASLDPEQGADWNVNVSFQPDNSGASKGMWARKPADASTMLLAIPAQSSRVPFTVDSPGVYRIDDIVGPFCGGEVGSPWTCEVVDVPPPTAQINFSSIDDRCAGPVGVKAMSVLTGTPPFQLEYEVTKQGRHPERKVRTIFDQTRDELDFRPDVDGAVTYKFVKLHDSNYRGIPLDGPSFTQVFHPLSSAEFTAPIRMHDDRAVMQSCSGKQAEADVRFSGAGPWDLTYAVRAGDQVETKVVKAISQSPHKLKIDIPTSMAASGGLVTVSLVKIRDARGCEKSLATRDLNVEVRRVQPSVGFLPVKTDTGRHQEVLAGKAAKLPVRLSGQGPWHVDYSYRADESAEEVDLTASLHGVDGELLAERPGLYTIKRIRDNYCPGIVLEGQEDFRISVRPQPHVQFAPEAGTGARNGSLIRAPVCRGQPDSVDIVMSGHFPVDVEYEHISPSWNAGSDGEGNVPLASAAHEVAMHGKRRKTAFTSALGTTNLELSTALSGWHTYVLNTIGDAVYAPSRLQGFSTEAPRRLEQMVLPLPSASFASSGSKHSRPSLCVGDGLDRLSTLPVLKLHGQAPFTVSFEVVSALGSTGAAGVVSHRFTRMGIQTHDYKLDLAKDEFSFSSKGLWSIRVVQVTDANHCQSAVSDGSKRSGEDKAISIEVAETADIAAVSSREDYCVGEVVDFSLQGSPPWTVAYDFNGKAATAAVTSSEFSRVADKPGVLTIKSVAHQQNQCRRDIDARVAQEMVKTIHALPSVRISEGNHFVEDLREGNQAQIIFSFEGVPPYSFTFQRTQPVDTHARPKVLETNTVSGILEDRYSIWAAVEGTWSVTWLQDRWCQVSIDYHSGAATPLGKSRLAIKNEPHNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWB1</accession>
    <name>W3VWB1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWB1"/>
    <dbReference type="HOGENOM" id="CLU_002220_2_1_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="728"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1254" mass="136498" checksum="964A9AB643A804DE" modified="2014-03-19" version="1">MGCLCSTRQVSLDEDLRSGDVWHKKDFATELADAHLLCLSLNGGVLGSLQCREMRRWDAGSGEIDPGLLGSIMGAGSKKREGQHFLEMYGNHKRAGDSNIVSAIPADNIQSQGRPSIMSIPSSRVDLGAAAFAASKPSGVVTCTSDAVRSPTATQGEMSKNAPVLSLPSLNALFAHKVKTMGDSVFLCVPKKDSSFPASSFEYDQYTFSQTDSLVKKICAKYARILPPRRHEDAQKVVALFADSGFDYALNALAICRLGHTVAYLSTNNSVPALAHLVKATKAQCLLYGTDQTSKILDLKAFLLEQGQTSTQMMQWTTVAEAVETSPAEDQTGREAFPASQLSYAEESPEVAFIVHSSGSTGFPKPILITHRASVANLASAFGRDGFITVPLFHNFGHASFWRAVYAGKKLFMHDGRLTADVLVDAIGASTASQFYAVPFVLKLLSESERGLEALRRFELVTFAGSACPSEIGDMLVQQHNVPLVALYGSTEVGQLMTSFRDFATDKEWEFLRPTAAFKPFLHLENVGSDESGPFEVVVDSKWRALTKSNRPDGSYATSDLFVRHPTLPDAFKFVGRSDDTLVHYNGEKTNPVPMELAIRSSPYVAECLVFGAGRAQTGVLVVPSSLAVEKAQAESSAASEASLDRQLGRLVWKAVEAANREAPSHSRVVPELVKLLPADTKFSSADKGSLIRAKVVKAFEQEIAQAYADYEAGTAAGLESVQIQQVDDEPSAISVVAQVVSEVSGRPISPPPASAEFFNVDLIQLGIDSLQANRIRNLLQQRVQLPSRLPPNLVFEHPTVRKLAKFLLSSARGEEQSASSVDRNASENQAMHTTMQQLERLLMVRDATIVQAAAAACAVPRKHTIVLTGSTGSLGAHILQQLATMDDIKTVVCLNRAKSNDDAQKRTEESLQVRGLSSTAQIVAEKGVRIVCLASDLNKPQLGLDNDAWGYLLKDTSCVIHNGWPVNFNMSVESFSSSLFGTVALMNLLSQTVGTQSPRFIFSSSVSASARRLGNVVEETISQDAKDAQEMGYARSKWMVERLCGVAQQLVGGGFDAVVARIGQMVGDRRSGIWNQTEAVPLMLKSAQTVGCLPNLPEQVSWLPVNDAGFIMARLVQPAKLHGVVHIVNPSLTPFAKVLELLRAPHNLGDSFEVVDTLEWLRRLAESDKDPEKNPTIKLLSFFHSKYDPSLQAQTLTEEYARRKQAKKHQVSHLQSVFQQLGLEQQLRDRLVEVDDQLLTNIVAAWRRDGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWT5</accession>
    <name>W3VWT5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_00348</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWT5"/>
    <dbReference type="HOGENOM" id="CLU_030279_1_1_1"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS65272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="478" mass="53998" checksum="88D899108F142476" modified="2014-03-19" version="1">MQRLGRGQALVAPKRWAQKLHHVHQAHEAVSCLTIPLSLGFHQSRSALTRTRSQRRTSGRTFTSSALRTGIPVSESNPRLVPQSPVSRRKFPPPSFPPSFGSNQILPVPQDTDRRLHNILACFDTPVRFAFAYGSGVFSQKEAGPEHSKRPATKDGKKMVDFIMAVTHPQHWHSLNMAQHPKHYSMFSRLLGGLGIGLIQPVGAKIWYNPYITLEDELVKYGVISVDDLCTDLLDWETLYVSGRMHKPVALVTSDARVRLAQQVNLASALRTALLLLPAQFSEVELYTRIASLSYTGDFRMSVPGGENSNKVRNIVLNQRQEFRHLYAGLMRNLGTLSVEEVGQNRYSIHQDDSIATRASYAARLPRCLRQKIQDYYTARPDLDPAFLKLSLSKTLDTVPREPSRIEREETLNQFWRAVVQRKDFDQVLLQMIAKTVKGPAWSQSIKGIYTAGFTRTFRYVAAKIGKYFEGKKEAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDQ4</accession>
    <name>W3VDQ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">PaG_06260</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDQ4"/>
    <dbReference type="HOGENOM" id="CLU_018204_0_0_1"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="84"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="199"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="307"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="ETS59738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="462" mass="49931" checksum="73F2CE7DE6808C00" modified="2014-03-19" version="1">MSLRSSSSRLLARTATQAVAAPRAPALATARGLTTASHTAAWNAVATKPAAQKLVSAVRAFSSSSAAASDFESPFGVNSLSKFTEEEEMLREAVQRFAQDVVAPRVEAMDEAEKMDPEIIKGLFEQGLMGVETSADHGGAGCSFTAAIIVIEELAKIDPSVSVLCDVHNTLVNTVIRKYASKHIQDKYLPQLSEKSLGSFCLSEPASGSDAFAMKTSCKKSDDGKTWTLNGSKMWITNSAEAEFFIVFAQSDPAKGYKGINAFAVEKSMGVEIAKKEKKLGIRASSTCTLNFDDIQVPAENLIGEEGKGYKIAIEILNEGRVGIAAQMIGLAQGAVDKAVRYAAERKQFGKKITQFQGMQFQISQIMMEIEAAKALTYNAARLKEEGRPFTKEAAMAKLFASQVAQRASGSAIEWCGGVGFTRETGIEKFWRDSKIGAIYEGTSNIMLETIFKLVEREMDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDW3</accession>
    <name>W3VDW3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241865_0_0_1"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000405">
        <property type="entry name" value="Related to CLD1-mitochondrial cardiolipin-specific phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="349"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="733"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="845"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="967"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1443"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1515"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="879"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="981"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1523"/>
            <end position="1539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1669" mass="178203" checksum="58E56E23147347FA" modified="2014-03-19" version="1">MPRAWSCVRRCPNNLRLLKASGAVSSLGRSVSLPTPRLFRARTLSQVAFTMQTQHPSAFGTPDSASSGAATPELSAEQQKRQASLLSAQTAPASPALRATLDADAGVKPMSASDTALATPISDAAYVAPPIPSSFKTSFAAWWKANPVEDAAQAELHLYRSTGYFEGATVNNVICADEELRDGKGLAKGLEWARRAAGSSQTSSSSTDPAHSSSSSLFSTHKFWPFHRSKEPSTMTIGLTPAADGKVGCIRLVDIGSAPNVGDTRPASRPTSLTSSPAVAPSSTEGLPAPEASSLGEPVLNDNLESHQIMSQDHIKPYTPPSGRKLNMLEIGIPYSKDKEEQIKNETKIVLAHGYGAGSAFFFQNIKSMAEVPNSRLYVVDWLGMGRSSRPTFHIPSSETKSTDTRVAAAESFFISSLEDWRRKMGLEKMVLVGHSLGGYLSLAYALRYPSRVERLVLVSPVGIPNAPPEDEPGSTFRPKNGSAVEQEVRQPQEDVAPQNARQELEDTQTANEMAKKAAQNRAGGVIQGKGSDAASAPRSLERSQTAQSVDSAKVPRSGQSSEPEKGSHEPPRISKRVRSVFSFLWEQNVSPFGILRSSLFFGPMLAGRYTSRRFGALPEDELRSLHAYCQSIFLSKGSGEYCLAHILAPGAYARRPMVERIERLKMPMSFLYGEHDWMDVRGGKEAVKRLRKQGNAQTNCFVVPNSGHHIYLDNPSPYNSLIARILRGQADASIKEGRPRRSTPSGERLGSTGVTGPSRASPLGAQQLIRAVAGVQQRTAPQTATLNQPTLLLCSRIRPGRGISVGRCSTLPANHHQPGLLHGHLHRHPHHCSTNTSTIARRTLARSPRVRKPVQHPSRGCHASVGGAPAPAPHQPRRSSALTIQSQRQPARSTIAAAMNSHQAFPAPPVEIFVDTRGAKIMEDGASSPDQRDSRDIYLPNHIEAVSHIAVDVGGSLAKVVYFTRSRSSDSTPSSPTPGSPVALSSPLPHSAASSSTPNALSPKTSNSNFRSRQASSNGGAHSGFRTPPAHADHPIASGTLTPTAILGSPQLASASAIHSTLLKRRSLPAALPGGRLNFIKFETNDIENCIRFLRELIERSASVNGVSIEDMRKGVKLMATGGGAHLMYDLFEQELGIEVQKEDEMGCLITGLNFITLIPDEVFWYSDELVAALHSPLPQNPEARADAQALRSSVPLQHPLPRPSPNPPLYAPVFDSHPSPKLPCLLVNIGSGVSIIKVDDFGKFERVSGTSLGGGTLWGLLSLLTEADSFDEMLELSEQGDNANVDMLVGDIYGSVGLNHLGLKSSTIASSFGKVFRKDPSSSAPRNAEERRKKFRSEDICKSLLYAISNNIGQIAYMNAEKYNLDRIYFGGCFIRGHQATISTLSYAIRFWSKGTKRAFFLRHEGYLGAIGAWIKHVSNDPAATMTNARAVAAAMASSYAGSSAPGRATPSVPSGLGRSISPASSSDEPLDWAAIQAASMQPPVLNGDGLPEPAAPESPAVLSNPHLAHLQAEAAASADRTPTQESPHGQGALGSQQSDLDFLNDVLAQPSQSASGADAATSGLAHSNVLVDDDSESDSSVPAQDEAAQLKEILASLNALKIPTSDGTDPATAQMERNEILSLLANLEQTEEVVGGLEGKLDSLLSSLDTLLASQDAQQAAQQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE63</accession>
    <name>W3VE63_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE63"/>
    <dbReference type="HOGENOM" id="CLU_696614_0_0_1"/>
    <dbReference type="OrthoDB" id="10259654at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="396" mass="42796" checksum="CFA3C7FED038977E" modified="2014-03-19" version="1">MHHRRIITFSASDAPMLPSSSPTPEFEDRHDAGDAEEGMSPLSMLFDGIIADWHSQHALMPTREQAAYPYSPSSARSETSTCITTPDRSPQHAIPGLPPQPWKEAVLVHTAREDAMTMPGGGPLLDASSGDGLGFWASTPPPDATAEQETNSQSVQAPRRPERPVRPARPARPEHCRETLEDLDEGSHAPSAGVVSLRSMRKPPAQYYHPAPPVAPSETSSKFKLAPAPQRARAATASARTVERSSMDSTATFVSARSEMSLSTPRARRLPQYPPSASRSSGLPQQQPIPQPESSPEITRRPSLLKRLADGLRRSPSQCSDATASGPTDYAKIPRTPMEMITPYPSDPSPAPTLSRKLSFSKRSPTHTRIAQHGATEDAVVGQVPPRALARKLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFE3</accession>
    <name>W3VFE3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFE3"/>
    <dbReference type="HOGENOM" id="CLU_799557_0_0_1"/>
    <dbReference type="OrthoDB" id="10472510at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="347" mass="37334" checksum="BB5EBB2F96C08024" modified="2014-03-19" version="1">MCSTIARSGTASDEIAEMSESSSVHYQELYGSSNALMLGSRKKKSGLVAPHRATHDRRDVCWGGGPVLLRADGITTRRDQESLCTPSYRPAVYVFSRDREASSATMDEAGQASTMTGNVERDAWAASTGHGARPLGSTGESTLGPQRASMIQSIGRQTSSAMVRASAWRRKEPHPARCSLLTPIVCSITIAAHSSSSKAQDVVTKIVGNYLHRAVALRDETNTSGQLGSPGCWLSRAQIAPILRGEYTEAATRSPMPTTMTLDREKEVDSGIVDDPRAMQGRKVGGRRRRDEMRDADHSASCTTSIQAMSKAQALARKDGHGGSPLRSYVRSQTSAGRTAKRLPRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFF8</accession>
    <name>W3VFF8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFF8"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001508">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="369" mass="40786" checksum="C4FF826E66DD4ADF" modified="2014-03-19" version="1">MSSVDSSKGPRVLLTGVSGFVGSHVLDQLLKSDRNYHVTCVIRSKAKTEPWLSSQFADDFGRRLDVVEVSDLLAPGALDQAVEGKDYVVHVASPYVLKAQNNRKDIIEPATNMTRNVLEAALKAEKAAIQAGRKPQLKRIVVTSSFAAILNPLRGIEKRDYTYTDKDWQPITSTFLSSFYTPLAYLVSKTLAEKSVWAFLEQHKPSFDAATVNPPQIYGPIIHPVASEEAINTSSAEPWKLYKAGGPNGDGKVPVEAFWSFCDVRDVARIHVAALDNPKASNTRYLACGGSVSWQEVADEIHDNPEYPQALKDHIPKGNHGAKHRPTPLATLDTSRAQKDLGIQFRDWKESVIKGSLYSFVEIEKSWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFF9</accession>
    <name>W3VFF9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAP42-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFF9"/>
    <dbReference type="HOGENOM" id="CLU_041824_2_0_1"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="45430" checksum="6F6F52C2D2C75085" modified="2014-03-19" version="1">MSGQTLNDLIATVFLRASDPPPPPPPQQFDTRAPETAASSSSAAAQDPAQQTLSLLSRAQQLSDSVGVVSSNDALRDISTSSLRTLFLPSLEAELHQAVRTGTDHASRKRRLAQSQTAAAKFLNRTIALGVVPPSTKQLLGWTLGGVHPAELVGMGVDVAALGGGSAPHVREVKIAVFKLERALKQNLDEFRQAYRSKTAPDRVPGDVFYDLVFPVARAEDDDEDDDADNETSATTAPGGIGSVRQYLLALLNLHVLRAAQLVTAASQELELLRNMPPPPSVDTPSVATDSEWRLDRSRTGLATSGPLMAPSGKVLRPFTITKTREQAAKEVFRPGHRLPTMSIDEYLEEEERRGNIIQGGGQASYDAPTSTEERARRMENDGTKDADDAEEEQRQKDIHWDTFTEHNKRGAGNTMNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFG0</accession>
    <name>W3VFG0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFG0"/>
    <dbReference type="HOGENOM" id="CLU_752531_0_0_1"/>
    <dbReference type="OrthoDB" id="2556295at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834100" evidence="2">
        <location>
            <begin position="27"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="368" mass="40916" checksum="F07216B810273A7D" modified="2014-03-19" version="1">MRGISCLFVMTTLLVIAAALPQSSSGSRPNAGRRNWWSFRRTQWPDVPDRAFLPVADTNPTFAAAQAQTQAQQRLAGALQNAQDASTWSQAEISRMGGPGSAFRPVTKRPEDAAPSRPFLPAPAPSLGAGSSQEAESLHARADIPNQNSAQDRIYGLGHSKFVARAYPVDTPLFTHLYSDESLVPVNFEDYVQGIRLLSLGSAYRPEPALLRAIQSMIWTKLGRFGFNPMQVAGTPDLVEGQYLWPPLSRDRYTGNVNMPADVLRRLRGTVKDRLRRLRPSDPDLYHLQVNGRHILAFTTKPIYQVNLPFTPSRSDLWMFFEMMAPRDANAAVPHLTLLGSTFLPRGARRLMTSGDVMWPAFLHAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFG4</accession>
    <name>W3VFG4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFG4"/>
    <dbReference type="HOGENOM" id="CLU_107661_1_0_1"/>
    <dbReference type="OrthoDB" id="2555434at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646">
        <property type="entry name" value="YALI0F00814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19209" checksum="92B848BBC45E0AFE" modified="2014-03-19" version="1">MTAPETGAVPGGANVIKLSQRDLLDYRAVQRTFDGAYARTALGQLCYAIVILRLFQPKFFYVGLVYAILGIGFIPVAIFRYQMAVSNTNRFVALQVVDGHQSPAEEHASPSASNPTEPDGTTLIAPHPVDSVSQPEAPISAPLASRTVLRESFVTAGSVVAGATVFVGLAEVALLVLILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFI4</accession>
    <name>W3VFI4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFI4"/>
    <dbReference type="HOGENOM" id="CLU_026940_0_0_1"/>
    <dbReference type="OrthoDB" id="2556491at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992:SF5">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="565" mass="62101" checksum="53D3606D2D7810A9" modified="2014-03-19" version="1">MQRARLKLHVKPTPKPPPPLPAQTDPPQADTPSVVRSAMDADRGGAVAGPSRPAPKRRRLQFTSQMRTAIPRYNDDGTETVEYLHHQSTQRLKRKWDSIFERFKDAHLQEQDEIYLGNRANGEPIVVVKDRGSLRSLRQSMDFGVFIKDEELQGWKERPEARQLEEDDDADDDLDPSHAPEYARRPHQLDGDFQQSDDDEDGHDPAANDPDLREFLQAEAQRKALLGDDAADDEDDDDDDVIDFSHPSWIDYDLITPTAAPRPPRPKPAPAPVRTKTEASPPVLPPEMDASSSSEDDEVDIVTLHSDSDEELVESIRTKRHNIEQLLQCTTPFETLPYNDIVGLAGLLGIADKSARLYVDLVSDDEEPEPDSAGQEPWQPTHLPPTQIGIGSHSAAHAPVQSTPVQSPRKIRVKVEPNLTPEPLRSTTPNQPQRAPWSSPQQAGQSDASPTAPAEVSAASEPAPSQQIAEKRQSGAASHAQVAESPRAVPAPLTPVRQAARQPSSSSRARSSTGGTPLASRRSQTSRRERTPSPSALEDESLCGGPTRCTKTFCLHCVSLSQRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFN4</accession>
    <name>W3VFN4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFN4"/>
    <dbReference type="HOGENOM" id="CLU_362511_0_0_1"/>
    <dbReference type="OrthoDB" id="3366868at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="771" mass="81106" checksum="5A03B8806E0785AE" modified="2014-03-19" version="1">MAPPAWAGESSSSIAFSTNPRDSRVVSIYDKYLYDPKDLESSDPRRRELARKASQLKLHGRPVNALDANGLRSVDSANSRSPQRKSIAFSHNTKLADGRTAASATAPSNGTRQHPQPSYHASASSERFDESHDRDSGAFGLGLGMLGGSDSESDSDSDDERRKAPRNKALDQLKHSAELTRSDSWTDRAVAVGHRPPDNASQNPPSLKLMALKSAKNGGDASRTSQDDRRSRLTAQDNLVDRTSRHGSTIGFGGSHIDDHPDPRAQANQPPSKHLSARAALTKQLGLASPNPEANGHAHPNRGPSPAHSSGPHDYFDNRAPNVTQPRPNQRSAGPPPIDVARAQNGLGGRPQDVRGAPSPMGSHHGSVSTPTSATPLRSPGYSAHGMPSPNHPNAGVAPPPNVLQRGPPSPYDQRGGPVGPGGPGGPGGPPQYGPRDGNPRAGPGPGPGPGAGPPHPSSLQAGNHARPPPGQYPRQAGPPGPNQSFSDAPGPSKRQSLFRRSMAMLGGGPQAGPAGYGQQRGGPPQKRQSLFRRSMAMLTGNNAGPAPQQRGPQMPVPAPARAPAAPRVQGLQNDFEKPDHPRKSQFLGAGGEGAEWDTNGEGAKFWRRFSMAQKTAGTHKVEDGSRAWMASMASGRRKLIVMGFIALVTLVGIIVGVIVWREIVSPSGSTSDEPTAVYKANLGAKDNPAGTTTKAATSTSRNAKATATASSSSSYYNRALADGPSDEGSNLHVRRALAHELVTPRRRRRHFGQSAPVQPVNSQRSLAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFR9</accession>
    <name>W3VFR9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFR9"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="218" mass="24055" checksum="8962F928587528B6" modified="2014-03-19" version="1">MSNAPGASTAEFGQPLRKFKLVFLGEQSVGKTSLITRFMYDTFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDITNRASFQNTSKWVDDVRAERGNDVIIVLVGNKTDLSDKRQVTTEEAEQKAQEFNVMFIETSAKAGHNVKVLFKKIAQALPGMDKDADAANAGATANKNIDVTAAPAQTTMEDGSACKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFU8</accession>
    <name>W3VFU8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFU8"/>
    <dbReference type="HOGENOM" id="CLU_019699_1_0_1"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833124" description="PQ-loop-domain-containing protein" evidence="9">
        <location>
            <begin position="29"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39674" checksum="E7727E40B8AC3114" modified="2014-03-19" version="1">MLAQRSAPPRWAVIAFAALVLLATSTLAAPSSTENSTSPIPPAKHPHPHHKHQQKQVRDEWSSIMGWVSIACWVLPSFSQMHQNYVSKSAEGLSITFVVIWLAGDALNAAGAWFQGLLWTMIILALYYCACDCVLIFQYWYYSKYYHRGVKISTISASLEANERTPLIGDGSVIEDDLSAKDDSDDDSSVRTQIIMYTIAALLVVATGVAAWWVAEHSYGSDDDLPPAAPEPVGWRWDAQVAGWLSAILYLSSRVPQILKNRTTKCEGLSLALFVFAVAGNLTYVASILLKSTKHDYLVESFSWLVGSLGTVFLDFIVLGQFIHYRRARREIHRLRRSSIAHHERERPRINATPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFZ5</accession>
    <name>W3VFZ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFZ5"/>
    <dbReference type="HOGENOM" id="CLU_020801_0_0_1"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="766" mass="83351" checksum="E18185740AD8FE15" modified="2014-03-19" version="1">MPSRLSSSTMDRLLADETILRIFGYLDASDLVCLQAVSSHFRALAKDRHLWKRLFFLAFVHPTLASGSFDSARDAPLLPTLRELRSLLLHQHLPIGKYVPGDGLNRIARIPQRFYASQPGLDHAARDPLSSDDSEDRIADQHLDWEQIYRVSSKWQNGNFAASQLLSASRSQFGGPSPKAVPEQAHSTRLESPATIVRMSSSFIFIAAPCDDPEVLVYPCDNAPSRAEHASSSAPVPSHGDLHDRTPIARFTSPSLQRLMSQQPLDAELHRARVTEITVDALSVDTALNSVSSDTRKRKYRGTAEVSAGSVTTVVVAYSSGHVGLFALKGRGPAGHVGAQVDELAFLDTRTFSPATHVCMAALHSPALVLCSSRFDISFFRIASSPTESLKLEMVQRLSSFRCSWPASLRLKPLPYHPTQSKRPRRWSRSRSSERADREEHDQEVAFRATLAYSSPSYPSSWSVSVQEIVIQFHTNRPHPTAQVSSRHATARHSFRPTPLDLRGRSMLGGGFSALAPPGGAAQRADLDAASRSRTTTLTYDDPFVVVGASDNMLDVYELVGATTYVRQGAPTLGAGRSATATSLAAREALQLVHRRRLHGHTGSVHSVALEDGRCVSGGADGSVMVWSLGDRANDTESIASFMRSARATARGAGNASATMDEEDAEQAASSMTHVLTLRTPMEAEDRVQVGRAPGQTPQAGLSLSQIVRSRGFDRQARGVIRWVSTAFDKIVSVVAYSDASRTCHADASEETAGQARERIQVWSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG42</accession>
    <name>W3VG42_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG42"/>
    <dbReference type="HOGENOM" id="CLU_007003_3_1_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="529"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="882"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="928"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1024" mass="111034" checksum="CB564692BCA8C9CE" modified="2014-03-19" version="1">MDPGGVVLRSLRLCFCSVAPPLRRSAQIPCLTLRSRVGATWASCLVRTAMPATRRADETRTAHRRQPAVSTACDFCRRRKVRLVLRRCPSFLPRVLVQHDCADTCRFHPRSPRRSRADSPALHEAHDRIRQLEERIASIHNEPSRNAPTSSPHHARRSSSASALVSPSSLAQTQLPTSDNVQNEHNPGRARLSTADANAEPHSQHASHSRTHRSVGSAGNIRGSEPIATPSRHAPSVRDDHGSTIGSPHGSRARTSASLSPSPTSPTSSAVATIIADLSKSAGPHTAHDRSIQPRARPASQPPRQHSHATRAVMSNLRVNNRGESRYHGPTSASFSAPEQSGRDHHPSDPQLAPEPARSTPLAADFNSADNRGCHVQINPALLKDRLTTLAAHERQQEVMNVVSGKLDFDGVEPELALHLLNLHWNRQHHAYLVTYRPLFMRDMAAPPAKAKYFSKLLFHAILFGAAKFSDRIDQVRSDVNDPSTAGLQFLERVQQLLPEALIKSRITTVQALLLLACTHYARGSESAAWLHSGLAFRMAIDLGMNEDSIELVMSGTMTLEELELRRRVVWAAYVIDKIHSLYQGRQASIERRNLYVPIEFYDHFEETEFWTPVAYHRPSDDVAEAPDAARTAAASPAGYTGPIYSVSTFAELCRLTVIMEKIIHLFYSIDSGTRPERVQTERLIGMRAELASWRSALPVNLRIDSISPSLGRTGAMPRSRTRPPNLISLHALYHALTILLNRPFLPHGHLRSDDPATGRSAWKACVDAASSISSLMNLYRQTVSMKGAPQLISYINFCAAGIHVRLAAQLQQRAPTAGSGDVADVAASSRRYELKALRQCLQDFEENQDPNPGVVKAKSVIRNMAERAGILDLLNAADEEGGLSPVGQGDSPPMHISGSGNGAANGRNGHEAGGSLLGSGGGGMDVTPSSAQNSGTIVDSPSGATGMLGRANSALAQPSTFGVTPPYEIDFESILASFDQFEAAGATGQGGLFAGSSDAATNSDILFGFLRDYDPSYPTSHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG56</accession>
    <name>W3VG56_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG56"/>
    <dbReference type="HOGENOM" id="CLU_034754_5_1_1"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000076">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="199"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="345" mass="38450" checksum="F44304ED361FE50A" modified="2014-03-19" version="1">MSANYWASTQCNNWLIDRAQLELARHEDREYASETECAAIGIFFANLISIVCKRLNLRQRVVASACVLFSRFFCKNSYSAVEPFLVCATCVYVAAKVEESPIHIKSAVAEAARSFQEVGFRAMPTDNSSLAEMEFYLLEEMEFDMILFHPYRSLLAIYDAHGSDSSDSSATSSATAALGIEAEAFGVRGLESIETRSEARLAELDQHVLQMSWLVLNDAYRSNLPLLYPPYMLALAAVWIALTLHTPAYERINATLESMQQHRKQHQQAALEEIVPPSGEALTFFASLNVSLPLLAEVVQSLLEAYQRQSQAAKLVADGPGMVKLLERMRHARRTALLTTNAQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG67</accession>
    <name>W3VG67_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_06301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG67"/>
    <dbReference type="HOGENOM" id="CLU_161539_0_0_1"/>
    <dbReference type="OrthoDB" id="277961at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="109" mass="12572" checksum="6C45F5965EADF707" modified="2014-03-19" version="1">MSSKASSSSDMLPAKPTSTTTVTIAGKKKTTPWEKKLEQRRKQESIKQRERDMKAEKEAESDRKKQVTRERKQMAEEKARLEIMAQKMSAKKLARKQRRLGITKKVSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG70</accession>
    <name>W3VG70_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_06308</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG70"/>
    <dbReference type="HOGENOM" id="CLU_009308_0_1_1"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="786"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="816"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="558"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS59782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="891" mass="101999" checksum="5869B5B33F3F93C4" modified="2014-03-19" version="1">MKFGRTIKTSLYAEWADKYLQYSELKKEIKSRMAKNNGTWTDKDEDEFVAILSKELDKVYDFQKVKVKELAERIKQAQAEVNLLVSSRPNSSTSLPSRANSRPSSRGGSDTEGEDGSHRKRRSVGPDGNIVYAAHDAGSDDEFDTDTEDSDAYEERFLELEERLAIIIADVHDLALFTKLNYTGFHKIVKKHDKQTGRLLRKEFVQHYLSSRPFYKENYDQLIVKLSKLFDLVRTRGNPVQGDSSAGGNQSAFVRQTTKYWVHPDNIVPLKLVILKHLPVLVFNSEKEYQQEDSAITSIYYDNEDLELYLGRLEKTEGAEAIRLRWYGGMDNKQIFVERKTHREDWTGEKSVKARFPIKEENVNAWMRGDYTMDETFEALRKKGKKSDKEIDSMLQLANEVQYSVLTQKLQPVMRSFYNRTAFQLPGDARVRISLDTELSLVREDNWDGRQRAGHNWRRMDIGIDYPFDQLPAEDIERFPYGVLEVKLQTQLGQEPPQWIRDLVSSHLVEAVPKFSKFIHGCATLLPNRVDLVPFWLPQMDIDIRKPPTHHLAIERPSSMVHSPAGSSRPDTPASRSSHQPYNEPVSEDEFEAGDDEEDRGQIMADETHEADNVGISAFDPRIREAREERERNIKLRQQELESLRKENPDKTSNVAGGMLAVASAAVATERRASQTKSKAAAPSREEILAPSHRFDNQFFSKLTPKNIQRLWRTKGSSHEHDEDHTDAEADDEDERARRALEGQDEEVPRGPNVEYVRDFHAQPGKKVSVPIRIEPKVYFANERTFLKWLEFNVYLSALAVGLLNFSSPGDRTGLIASSFFTIVALVGIAYSGVIFVIRALKIRKRESSHIYFDAYGPTILCAAILSAVVINFVLRFTESHQHRNQRGVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGK0</accession>
    <name>W3VGK0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04602</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGK0"/>
    <dbReference type="HOGENOM" id="CLU_050757_0_0_1"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000003">
        <property type="entry name" value="Splicing factor 3a, subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="237" mass="26545" checksum="1C4DC08BC08E8E67" modified="2014-03-19" version="1">MDFSGRAGNKGGGIAGASESNVDRRDRLRRLALETIDLAKDPYLLKNHLGGLECRLCLTLHTNEGSYLAHTQGKKHQTNLARRAAREAKENAYDSNKLITASATEAMPKKQFVKIGRPGYKVTKVREPLLERGEGGRLGLLFQVSLPEIKEGVTPMHRFMGAFEQKQEAPDRNYQYLVIAAEPYETIAFKLQSREIDRRDTGLVTSSAPASRPRPEPSTWSHYDPDAKTFSIQVMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGP0</accession>
    <name>W3VGP0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGP0"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="534" mass="57126" checksum="1BA75557E4DF75FD" modified="2014-03-19" version="1">MAEAIDVPPVDNPRAWSTRKKVRVTLILGSMVLSFTYLSTAFALSATSLQRQFKASAEVVTLGLSLYVLGFALGPLMMGPLAQTMGKRPVYVYSWIVFTACCFVMSESNNLAVILAFRLISSIAGSSALNNVPASYSDMTTPARFAPFFTCYGFSAFAGPSLGGLVGAFVNERAGWRWNLRHQAIFVAVVTVFGVLFVPETDHPKLKRIHDAKYALNDGQKSVETADKARWSARVADATHSFGTVVVRSVKLPFHWLLTDRVVLVISIYTSLLYAIIYDFFVIIPFAFASIRRFKPESIGLIYITLFIGFAMASSNYVFVQEAINRRIRAKTGKTVLPPETSLFHAIYGCALAPVGLFLFAWTVPFTSIHWIVPAIGIVLLCAGSMSAFTSLIPYLVAYGGPSAPSVLAAAGFCRSALAAALPLFTRQMCKGITVQGATSLLGGLALLLTPLPLLLYIHGGKLREHAKQRKEAAAASATAAAAASTAGSSEKDLADKEEQPLAQGASIPPGGAIENQPSQSSLDISSAPSGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGQ3</accession>
    <name>W3VGQ3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGQ3"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="307" mass="33385" checksum="688557A522606D85" modified="2014-03-19" version="1">MAELITANDPRKVVVITGCSSGLGRSMAIEFAAQPHYRVFATARNVEALRELPATIERVQLDVTDTQSIKAAFEDIRHCTKDRIDILINNAGVNLAVGPLIETPIDNIRKTFDANFFGLIAVTQAAVPSMIRRRSGVVVNIGSVAAIACMPFGAPYSASKSAVHALSDTLRLELAGFGIKVVVVAPGAIKSSIADNTQKNLPTAPRGSDPDDLGYLPADSLYKHVEDLVKFRAEFSQQGEPTPSETFARNVRKWVAASNPGAYLFTGKKSLTVWIAYYLPTKVKDWIVGRIFQIHRIGTNAHKNKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGV1</accession>
    <name>W3VGV1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGV1"/>
    <dbReference type="HOGENOM" id="CLU_025145_0_2_1"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924:SF1">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="95"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="485" mass="53621" checksum="AD894C354B550DA8" modified="2014-03-19" version="1">MASINVASRPKQPYVSVSCPYTTCRSSIEYLPPSAAELAALPSHETSFTVTCCTCSKQFEPPGATKLVRDARKSGGKDVARKRRIGTDDNPLDMTYYDILGVPASATLEEIKKAYRKLAIKLHPDKNPNDAEVEEKFKALATAYHVLSDAELRHKYNEFGASTPGLTPEDGFVDPEEVFGSLFGGERFADIIGTISIGKDMKEALQQDSDDLERQANGEEVAAGEGSTKPVLTPEQKAAKEEKERVQAAERDKQRQQRVAKLVEKLVRKLSIYTESIRSANDPTLEREVEKSFREITRIDAEELKHESYGVELLHAVGFVYSAKSKHYLASTGFLGSFGGVFHSAASSIHVVRETVSTVRAALELKSVFEELAKAEEQGITVERKRELEEQAAEKGMRALFKGAKLEVESVIREVSEAVLYDASIGKETQRLRAQALGIVGEIYMAVKKDDDKPAEVEDYVKVDTQASKQREKAQSQSSPPQNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHH0</accession>
    <name>W3VHH0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_04906</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHH0"/>
    <dbReference type="HOGENOM" id="CLU_022696_0_1_1"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="167"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="472"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS60975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="565" mass="62703" checksum="9DF61011ECBE885B" modified="2014-03-19" version="1">MSAAAASKKGARKLSEDPARFVVPHPPTSVHHIVGSTVTMAKLPSQAACRACLGARQTAQPAQIQARVPQVTSRLHARARSLHTAAALASSVRSAASLHSSLHSRAFSSSPLHNFSGSRVSHLPTSITILGKEYPTDDHTNIPDSILSRLAPSPTLPYTSNHPLALLRDQIEASIGPNYTAIQATSPVVSTELNFDDLGIAADHPGRSPTDTYYVNRDTCLRTHTSAHEVQTFRNKHERWLLTADVYRRDEIDASHYPIFHQVEGAAIFAHEDYAPGGKVEQECIEMERKLAGANFEIEDVVGLSEAGGYQSHHDPREAALAVRHLKATLNGLALDLFGERHAYDAAQKGGGSEPLRVRWIPAFFPFTSPSYEVEVWFRGKWLEILGSGVVQQKTLDKAGVPDRLGWAFGLGLERIAMVLYSIPDIRLFWTKDPRFLGQFASAPTNQVSAAGGKATSTKASKPKLLTFKTYSKYPPCYKDVSFWLPQERKFHENDLFEIVRDRVGDLVEDVVKIDDFVHPKTKKQSLCYRINYRSMDRSLENEEVNQLHSDVLHRLVDQLAIEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI13</accession>
    <name>W3VI13_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI13"/>
    <dbReference type="HOGENOM" id="CLU_009935_2_1_1"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF4">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="7">
        <location>
            <begin position="120"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="484"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="754" mass="85737" checksum="1C1BCC7FA4BE3508" modified="2014-03-19" version="1">MSNHLICASSAQLPHDLQIGLPDQTPSNSPRWIDATPSACLFSGPRARAKDGVSSISGTGDPRRRIDHLPSTTFALNMLAKHSPKPSKDRRPNRSHPDRNSAAEYDPNPRFRREKSTLDLTGVWDFAADDDNFGLQERWYEPGSFPRSQQEIFVPYTCETSASQLSDRRQHKIVWYRRDVFLASDSDTIQWSEARKHRYFIHFGAVDYESTVWIQGHMVGSHVGGHTPFSFEITEHVWRLHDDNASSSLEIVVRAKDAPQDMSQPRGKQYWKQNLKGEYQPVSIFYTPTTGIWQDVYLARRPLKHIRSAQFVCDIDAGTVRAETEIDLLHTVGTELAPNYWVQFIVKLGRRTISVCKTRVSRQTDSCSAVINVRQAGEQPEGPMRTRLVTPGVLPPEMNRDRWDNGLALWSPESPSLYTVEMRLLSDDSEEDRVQSYFGMRKVSIDDQGRFCLNNRVYFQKLILNQGYWPEGGMTTPFFDGYADDIRKIKQMGFNGVRMHQKVESPEFLYEADRLGLLVWGEMANAYEFSTTYLERFTREWIEVVRRDMSHPCIVVWVPINESWGAPALNTSAQQRAHLASLYHLTKALDPTRPVVDNDGWQHVATDLITVHDYRNANELAKSFSSREQALQERVPGFPILLGPLAQSEERYRLPLLCTEFGGLALRVDNVGTTAKGVDWGYANASSQADFLEQFEALVHALTRPSSGAESTRLVQGFCYTQFADVEQEVNGLLTKDRTFKIPPAKIKAILDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI59</accession>
    <name>W3VI59_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05341</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI59"/>
    <dbReference type="HOGENOM" id="CLU_015528_0_0_1"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF488">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="616"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="841"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="866" mass="92686" checksum="BF2E2D41D3C57F1A" modified="2014-03-19" version="1">MSHPDADDAAAPADTTLRDTANFPSSRTLNSSSRLSNYTEAPTRRSSFQSAQASLYQDTDASLAFDDARESFDLDSDLEPTRPRSAASFRAADAMHANRRSLAASEDELETTVDIPASPSFGAPGLARRRSSKRTSVEMSRPLSSLSRRSSISGAGHDEPHNRLRDAAAAAASRSSLSNRRHSVEIDQLARNISRASTPHGFRTEDEDDDAPAPRPASRSGSSLALRRYDQDGGSFIKRDGRDRGSILPPAAFFAPKKPSARNSTGNLLESTATNIARSTTPLSFRSTTPAPSAAPLHSANADSVDSQAAQEVLEYRTTSPTGYHQHARSPSPWGVAASVHSASSSVRHAPAIGSVVTDRNDALNPATAPVTPLGTQDAFGHAAGQASPHSVVRMMASTDPLLPARAIPEATTASGLGLGTLEAAAASQAARADARDMPDQRASLRNGGADAAKTAATAAAVPNGSGKAEPDAVGAQVKGAKRGVRNYRQHKGGNRFLLGGLLMTSSDNPLPFIASYLLLLVLGGLFFGFEAKWLSDNLSPAVVAVFAYVWLLAVVNMGVTAWKDPGVIPRGLDADPPCVLGDTSYEPGRQALADPEDPLAVPVQRVLRIRDQTVQVKWCETCGTYRPPRSSHCRVCDNCVENIDHHCTYLNTCIGRRNYVPFLVFLSASIVAALYVVAFTAARLVLMTKPTTYRYPRGGAAEGYSFKQALEESPVSAVLFVLSLAAAAPLVVLLSYHVRLVLRNRSTVEQIRINTARDYGEHKQLELDPAGDDDATSTYGAADRPRRGGLRAWLVKIKIARPRYKDPNPFAAARTRTNVRNALGWRSLDLGSWIDRRAVHEPDTRAPHPRPTADAPATEAPAWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI85</accession>
    <name>W3VI85_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI85"/>
    <dbReference type="HOGENOM" id="CLU_1434997_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="189" mass="20082" checksum="FC39342F3FED0987" modified="2014-03-19" version="1">MLAETKLLGMYLALICSEPMQSIVDGCMVSPRPTVVADEEHALNALGNADMNPGNDGISGGQDSRSGGAVGEQEIHVAGILAVCLGNLVEVLRKPQGVESDAVESPPRHSLALRSPDRTTLSAIPRVGTPPAEKRAIVAMTTRRGSPGVQDWVLSVLQFHRISLVIPAGREKWQQRPGQASSSLESLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIB2</accession>
    <name>W3VIB2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIB2"/>
    <dbReference type="HOGENOM" id="CLU_005126_10_1_1"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="43"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="965" mass="102637" checksum="0A4A7BE84E828602" modified="2014-03-19" version="1">MARFLVARAAKSDSVFGGSDPTAFETSNPLRLFIIQAAIIIIVTRVLGFALQRLRQPRVIAEVIGGILLGPTAMGRIPGFTKHIFPPPSLPYLNLVSTLGLVLFLFLVGLEVDVRVIRRCAKESTAISVAGMVLPFGMGAAVSVGIYNAFIDKENVSFGHFILFTGVAMAITAFPVLARILTETKLLYTKVGVIVLAAGVGNDVVGWILLALTVALVNADTGLTALYILLCAVGWILVLFFLIKPSFIWLARRTGSFENGPNQVMIMITLLLVLVSAWITDIIGVHPIFGSFLVGLMVPHEGGYAIALTEKMEDLVLVVFLPIYFALSGLKTNLGDLNSGKAWAYTVAIIIIAFFSKFIGCAAAAKAFGFNLRESAAVGTLMSCKGLVELIVLNIGLSAGILDTRVFSMFVLMAVVSTVITTPLTLWVYPESVRTRLDDASIHSHHGKTISGDEEDDTDTSSRLSPKRLLVVLSSFEHLPGLMTLVQLMQPTLAAANPTSNLANDASAGLRRRRSKQASAGSEGDAAEKSTEAGDDSVNSVDGADDGQYQPPTLASEAPYASIMAARSQAQISIDALRLVELTDRTSAVMKVSESEDTMRADPIINVFQTFAHLNGLPVQSTMSVIPQEEFAPAVTRRCKAAGSNFIILPMTLSQAGAGQGSGGGAQEAAAAGPSSPLAATLTNPLESLFGGGWASNASDGLKGKYSAQHFNVVRKIIQTTETDVGVLIERKAQQAGGLGMLSRVGSQSILFAFMGGPDDRAALDLVSRLCANNRHLSVLVVRMSRISSEEAGEEQLPTVPPTVHHEMSLSHAHHSVLRGGSNMDTVYPTQYGGGVAVQSALEATLEDDLALQRVQDQVAADRFGGRLTLETVSTARPLRELMQLAESKQPAIVVVGRGRRNPTQTHREELKALIQTHHSADATERQLNSEITKVIGEAATALTFAHTAASTLVIAAGFSVAHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VII8</accession>
    <name>W3VII8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mfs alpha-glucoside</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VII8"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF53">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="63"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="571" mass="63426" checksum="29A19684CFE3122C" modified="2014-03-19" version="1">MSSSSYEAQDVLRVEDHESDAIRSELGSDYGKVVAGAEAAAIHEQQDLGVVEAFRKHWKAALWSLGLSTALVMEGYDVVVINSFYGSNAFIDRFGTVVGNSKVITAPWQTGLSNSALVGEVIGLLVQGWASDRWGYRPVYMASMVFMTLTIFIPVFAQSLPMLSAGEVLMGIPWGVFQTLTTTYAAEICPTQLRPYMTSYVCFCWGLGIFLSSIVVRATLNMAGQWAWRMPFALQWVWPVPLFLIAYFAPESPWHYARKGKYEEAKASLRKMQTTQSGEDESHIDNKVSLMRHTNALEKAETAGASYLECFRKANVRRTLLVCIVYSLQWWCGNPLMSYSVVFFRRAGLSQNNAFNLNIIMNTTYMIGTVSSWFLLRGMGRRTLYLLGASFCCLHLILIGTLGFFDSTSISWAIGSLLITFALAYNCTIGPGAYTIIAEIPSSRLLAKSIVLARLTYVLTGLVTNTLTPRMLSPDAWNWGARGAFLYLGTCGLILVILFFQLPESRNRTTAEMDELFHHGVPARKFASTKLDLYHAKHFATPNDGARIASLTDSKDEKDLDHPVNIATLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIR7</accession>
    <name>W3VIR7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-type atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04315</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIR7"/>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_1"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1013"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1043"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1084" mass="119903" checksum="E21F2217BB8C74AC" modified="2014-03-19" version="1">MSSADTKSVSDYDIEKNHSPTNESANQVAIAGPAAPRVSIKVPRTQTTQTTRSHIPIGFRTLSIQVYESQGIDSAKGGKANLSDTEFFGSLDFHTVEPEALAQKFNVSTSAGLDGQAATRRLERNGRNVLVQKKNKYWLKLLNYTFGGFCSILWIGVIIFFISWKPLGNPPQPYNLALAIVVLIVIFFQALFNAFQDYSTQKVMNSILNLLPENAVVIRDGEHRSLPASDLVVGDVVVLSTGNKVPADMRIIKASADLKFDRSVLTGESEEISGTVESTDSNFLESKNIALLGTHVCNGNAVGIVVLTGQRTVMGRINKLTNDDKDKPTQLQKEISRFVFIIIGLTVTLVLIMLITWLAWLRRDHPAFLSVVGILTNLMSLVVAFIPEGMPIAVALTLSLIARRMRDVKVLPKSLATVETLGCVNVICSDKTGTLTENKMSVASIGFVDQETTRDDAASVEQTIAFDHLKHGMALCNDAFFDPATDNLPIAERTIQGNATDGAVLRLSASLPGSDDIKAAYRRVYDIPFNSKNKFMLTVMRSNADNAAATSADDMYVKGAPDVLMPRISHYYSAIDGETKIFDDAARSQLVSRQEMWSRRGERVILLAMRQFHAYAKPGTSEYEEEVATASESDLVVMGLLGIMDPPRADIPHTVSECRRSGSRFFMVTGDFSLTAAAIGKMVGIFTHNGEPDRIADFDFKNRFATDGPELSEKELKRLNGPKDIIEAGLLVEGKEIPEITQQQWDVVCRYEEIVFARTTPEQKLRIVNELRDRGCVVAVTGDGVNDAPALKAADVGIAMVSGSDVAMEAADLVLMGDFGSIVQGIRLGRLVFQNLQKVISYLLPAGSWSEDWPVVLNVFFGVPLPLSSFLMIIICCFTDLVCCLTLIFEKEEFDLLSLEPRNTKTDHLINKAIYGQSYLFIGMMETITAHSMFFLYMWRYAKIPIRDLFFAFEKFGDGFHGYTLDELNRFLNTGQCVYFVTLVILQWGNLLSVRNKRLSIFQADPIRKERRNPWLLVGALGALVIAIFVTEVKGIQNLFGTASIPIEHWFIPIPLAIGLLGMDELRKLLVRTFPNSVIAKIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ35</accession>
    <name>W3VJ35_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ35"/>
    <dbReference type="HOGENOM" id="CLU_118731_0_0_1"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="197" mass="20680" checksum="B16B54DB931F6EB3" modified="2014-03-19" version="1">MFTAARAASRSGVRFASTQAAVSEAAATARGAAKEGLGEAKGALKETEGAVKSTAQSAKAALPSAPSAPSAPIVVGSPTIRRPVGSVRGGVLGFLFGFGIASAYGYAYLLKEYNAASNLMLASVEELQSSTEKITTHLQRLNKLEADLKSLGSQAASRAEFEKNRAEIKRIVDGIHDEVLDVKKQVIDLPRPTKYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ56</accession>
    <name>W3VJ56_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ56"/>
    <dbReference type="HOGENOM" id="CLU_007526_0_2_1"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="394" mass="43841" checksum="138B74FDC000A2C1" modified="2014-03-19" version="1">MSNKVGQEYGEVRHAFDVSALNTYLTRHVPAIAAPVTVKQFSFGQSNPTYILFDRNDVRYVLRKKPPGSLLSSTAHAVEREYRILKALHTYTTGLPEGSKDRIPVPEVFCLCEETAIVGTPFYIMQFINGRIFEDYRFLQLPKPERAQCWASAIDTLAALHRVDVNKVGLNGYGKDAGFYTRQMKSLAKVSSVQAAIKDKETGQQVGPIPGIERFLKWFAGNMPRDENTIVHGDYKIDNLIFHPTEPRVIGILDWELSTLGHPLSDLANLLQPYSTQCTDVAGISKAETWEKSRKQGSLLLALGGLDEQTSPVPLEASLIKRYCDKARREYPIPNWTAAKAWAWFRLAVISQGIAARNAQGQASSAQAKVYGAKFPLCAQLALNIIDESPQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJD4</accession>
    <name>W3VJD4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJD4"/>
    <dbReference type="HOGENOM" id="CLU_099529_3_0_1"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="207" mass="22604" checksum="F186CE571B642A6E" modified="2014-03-19" version="1">MATTESNYRSELSGFRWAQGRTDDSRSQAASGPSSYLSTLTNSISGYVPLRSNERTNEEEAYLSLSRWERFLGFLACIAGAAVCFFFSFIFLSPPILALRPQKFALAFSLGSMLFMIGFSVLSGPLAHLKHICSKERLPFSIAYFSSLALTIYFAVGPRKMLPTLIFAVIQVGALVTYLAAYFPGGTTTLRYGGSMILRGGASLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJE0</accession>
    <name>W3VJE0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJE0"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="295" mass="31229" checksum="63907B460B273B5F" modified="2014-03-19" version="1">MTARDPVVLPAADPAKVFRPDIFKGKVLFCTGGGSGICYEMTKTIMSFGANAAILGRKADRLAKASKELSAATGQECIPCPADVREPEQLKEAVRKTVEKFGRIDFVIAGSAANWLAGIEQNSEKGFKTVIDIDLIGSYNTVKATLEQVTKNHGSYIFISATLHYFGLPYQSHPSAAKAGVDALSRVLAVEMGPLGVRSNVIAPGPISGTEGMDRLAPKGMEEAVAEMVPMMRMGAKSDIAAAGVYLFSDAATFVNGTQMVVDGGAWHIQGPMLPYPTTSLDPKSLSDLVTGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJP2</accession>
    <name>W3VJP2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJP2"/>
    <dbReference type="HOGENOM" id="CLU_1116152_0_0_1"/>
    <dbReference type="OrthoDB" id="10647047at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="249" mass="27377" checksum="CD57567B11244D8C" modified="2014-03-19" version="1">MKGANDRSPSLNLAMHVVPSEGTTVRIAAPALGTVKVAVVVDVHVRFAVANVDVDNFGLRLADLVISVIVQAGWWLAPTSALELTRFDQSSARFDRPPFDLTIVSGTAAGTSSPRPCYHTINPVGVASSTQQHEQHDSTFATMDSGTYRKRERFVGTITAITQRKPWDAAEIIAQDRASTLVRRAAADQFIRSFCEKVYIPEVLGNTCITAADIPSSPPRHDVSKDRQFWKMLATFVIHRFRESLVNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJT2</accession>
    <name>W3VJT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJT2"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="70"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="328" mass="35115" checksum="B875D5356A39F6B2" modified="2014-03-19" version="1">MLFSAATRSCAVRSAYSSIRPLERRPPTLYLARTFTASCAITSQTPSPAKPAQIFPSMTTVFPTQRLHNKTVLVTGASGGIGKAAAVLFARAGCNVVLTARRAEALSQAATECSLANQQGQTGAGGNFAAITLDMRDRTQLDGLLASLPDWAKNVDILVNNAGLVLGTDKVGDISPDEIDVMLDTNVRGLIHLTQIFVREFKKRNAGHIINLGSIAGREGYPGGSIYCATKFAVNAFTSALLKELVDTPIRVTEIQPGMVETDFSVTRFRGDKNAADKVYQGLQPLTPEDIAEEIVWAANRPAHVNIAESLVFPVNQASPYHAFRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJV8</accession>
    <name>W3VJV8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJV8"/>
    <dbReference type="HOGENOM" id="CLU_444237_0_0_1"/>
    <dbReference type="OrthoDB" id="3253553at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="619" mass="66191" checksum="EA0640DE9BBF8F50" modified="2014-03-19" version="1">MQYYADHGAQGARSSYPSYPPVSASSPHYPHQQHHNNARRYSGESSRPPSQAGSSRPPYGQPPRSPLASLPAHGRDESDEYEERDLGEIAAANQAAQEQRWGPHAALSEAPGRFDAYHDPRHDDFHAPMPTMPVYESAHYDGGFYMEPPGLYEPAPQYRPAPSLGSPSIASSHTLGGRSRQSLPVYASPLMAPSASSPASEPPNMFNVTAAHHTPGGRPRPFDDPRAQSGARVGDPLPGFPNWSHTWYGGHLSADGHAYTMVPPGSGQSGWESETISHHRPGYPGPPGAYGPYPYGRTATHDQVKEERIRMLEKEFGPKVKHKGKGKGADDDDDDKDDDDDESEVVPIGGVNAKGRLVLPRRKTRITTRVLQCLVSLVAAGCGIGGFLAIHPQEKAPPSGTMPSFVLYGVSALSTIICLYLFTIKPCRSGRDAGGAPMGGGGAGNGMVIPIMAGGAGGKPGKGGMFGKKGKSAMQQGTTVNLIVDPSLLGQRADESDSETDEDETLPGEERRRKKRRAKKRQKLGMLGNMKLQARWRVARTSLKWDCAWDVVMCLLWGAAAVMALGVGKKCPSGTAEGWCTLYNSAIACAIVAALVGLVAIYCDIVGLRASRAPPKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJZ7</accession>
    <name>W3VJZ7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJZ7"/>
    <dbReference type="HOGENOM" id="CLU_058670_0_0_1"/>
    <dbReference type="OrthoDB" id="2520628at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="395" mass="41999" checksum="3C7C8D91F213BE82" modified="2014-03-19" version="1">MPSPIRASVSGEMWDEQMPFASSLHFELGVRCQTGATLIFRSSSVPSDARLHENPARACSFRCVALSRTSSSSRKHVCTLAFRSPFFLHIITPTSFDAMQTARLASIGDQLSNWSQTPLHPLFPVGALGLIHAVRVSHATRQVAGSHKSRLGVWQGLVLNQILMFGGVVISGMLLGVPSPLLSAWPVVALYGGVHVALDVTPAGKALLHAQDTELVGTLMDLSFALLDGILRAEGIIDLGVEPVLRHASHQVATSLFAILLNAAIVGGGIPLLIDLFRLDSTTGEWGVRSPAWAKNPFSGTNDMLSSAFLALVYLTLARPATAPIALLRDALDAFGAESLDARDVRTLCSLLLGSILLAEKATVLSNQQAQHEVAKNGSVNGSAKSKSKSAKKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK45</accession>
    <name>W3VK45_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cullin-associated nedd8-dissociated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007157_0_0_1"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="230"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1530" mass="164808" checksum="D6960D5B0101D601" modified="2014-03-19" version="1">MKPRTRKAAVTDAALWLGGGHGSKAPSISRRMLDSEDAHVRSRNRRALVDRGGIGLLGEGDEGAAQDQGDADDLGWPAKQCPWRRRGSQGLHAGPRKGVVGQGESGGGARQFAKHPRVLQLQSVTRAVTEAGVGVQLSLATGAKAASTGSMVDVASSSRPLPASKQLKQCGSAFASPHGPRAQSSSTMRPDIPKVRHSHDARVPHSINRDRAEPCLSPLAYFHHPRRPSAIFPETMASSWAHTGIAPLLERMKSQDSDFRFMALNDLNAELSKDSYIQMDESTENNVVRKVLDLMKDTNTEVKNMVVRSLAILVPRLREKSLQLVVDTLIDYISSDNDELRDIAALALKTVTAQMPTRSSYATAALNKLAPKLLNHVADAAASQELLIDSLDILAELIAKFASSVTTTVALQNAILKAVVPAMRHTRPAVRKRSLTVLGALGSCATSDIFTQLSVQLSADLAAQSSLDTRKTAVQLIGIFARTCPRRLGRRLPEFMPAVLETAQIVDDDELRELSLQSIELILLRCPAEVTPFVNASIELATTLVKHDPNYAGFDEDEEMRDADDTLDDDDEDEDDDYLDEDYSDDDDMASAKVLNAALTSRPELLAHNVGAVAPILVSRFSEREESVRLEILDTFLALLKQMQLYGGGPQATEVIGAATTSSANQAAAIAAAGVLKRKRHEMDADDLEGSPRSQLVALVPAIAKALNREIVSKSIPTRHKSFVVLRELVVVLHGGLDAQIGSILAQTEKSLKGAESAPSGGSNLKADILGFFRVLFLTHQPKSFEDQLPQLVPVLAASIEDKLHRSCIEAFLTCSQLVSVLRPLGATATAPGATAARPGQYKPYLLHIYAATVARLNRLDSDQEIKERGIACLGVLLAHGGDNLEEKHAECFDLLSNRLTSEVTRFVTVKVIAQIASSPVCKGAAFDAFLRSAIAEVATLLRKSDRQLRLAAFDCLAAALSRPSNELSTESSNAILAEVQPLINSDMDMNLLPHVLRSINLILLSDPATRESVRASVLPQIYTVLRLPIAQGPAMDALLEFFRLLVGAQPESATEIVDELLAALDAAKGSVSGTHIYSTVSRCIGASCTVSAPASSIVADKATTTLQGGSAKDSEVYFALLLLGELGRFNDFSTRAGLLERVLAFYAADSEEVKMAAAFAVGNMAAGALGAFLPVIVGHIRGQADDKASAHRFLSLHALKELITHGSAEQLSVVAEEVWPVLFDASETKEEGARSIGAECLARLALSEPTKFLPLLQERLRSPSVSVRATVLAAVRFTLSTESSAAYDELLAPCLVDFLMLLADPELEVRRNATFALNSAAHNKPYLIRDHLATVVPLLYAETHVRTELLRKVAMGPFQIVTDDGLDLRKNAYETMYQLLDSLWSRLDMAAYIDRVVAGLADSDDGIKTLCYLMVIKLVELGSPVVRSVLAGRLEEIADPVGATLRSKLKETATKQEIEKQGELQRFIYRMLVVVTRAMDAVVGPVATPKFSALVQEARSAPAQHGNTTSAPGALWRETEAALATASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK68</accession>
    <name>W3VK68_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK68"/>
    <dbReference type="HOGENOM" id="CLU_1678683_0_0_1"/>
    <dbReference type="OrthoDB" id="10363235at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="157" mass="17044" checksum="3F15D59B1DC940DA" modified="2014-03-19" version="1">MRWVGPSEERRAHIFGSRSATAAKNEPTSLLHHSIGSETVLIAASAPLCVSPFFLLAPPLARQDSVAWTSAPHPASTFFTNPIISFRIFTCALSSSKPDSQGHPTRPSSPSSPPKRNPILRPQPAPVILSPALQELATLLDFIHASPSFHAVRRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKF1</accession>
    <name>W3VKF1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKF1"/>
    <dbReference type="HOGENOM" id="CLU_412306_0_0_1"/>
    <dbReference type="OrthoDB" id="2555569at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834273" evidence="7">
        <location>
            <begin position="22"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="600" mass="63055" checksum="8284F20EE1E39781" modified="2014-03-19" version="1">MKTQAGLAVLAVAVLASGCSAEATREVAGSRDLFDQMVQSLASKWMPGYRGDGLQWSVHPLPRNVKRQNSASPMVLQPAGDEDGQGLGSLAGLFGGGGSASVLAASPSRSATQASATDSASASPASSAASSAATPSADRSASSTSATSSIPTAPAFSFSTPSPSASSTSSSVSSTASARPSMSAQKDDDAPPPSLLSPKHKFFPLVVAGMAAAGLLALMLLIAIARAVAHDQLRRDKLKQSYGFDEYSDKPGKTGDKFTSNPGVGAARSLRRAMTRKKLGSFARRTADGSVLIEVGDEVFAVPPHLADSYRDRILREKRSRSDLSQEGLFGNVQPRHLNDGGPDADDSTARAAYDTMLQGEQRPSRSLSQRLTDRFKSITTSPKPMGAYSFDAREKGAVRQVDLARPTLTKGGAEWVVERTSARPPPPRDTSKPVTRKAPPKLELSTLTAKLQDLEKQSNVSSSSGHSRRLPAEASISRSAASSASANGTFGGSGSGSDLEAGLPGAFPERSKSLARARSVKPLILSTERVGGYRHRHPDAHRSRTQVRPTKPLERKSTVALASPTRFSHDKNPALVVHPEKPQAAFRPLPVPPPFTLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKG7</accession>
    <name>W3VKG7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKG7"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="42"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="358" mass="38342" checksum="6E65E0430EC2C757" modified="2014-03-19" version="1">MSHRLGLFTRHLSSLSLSNATRSNVCLRAMSTVRALQIEQQGGPEVVQVVPVPAPTLSGSGKVVVRNEYAGVNMIDTYHFGGLYKLQTPIVIGQEAAGVVEAVDPDVTSLRVGDRVVQYGGGSYIEKQLLDAERVIKLPDSIDTRTAAACYLQGLTALTLLTESAPVKQGDWILVTAAAGGVGLLLCQMGKAFGANVIAVTSTEAKCQLAKAHGADHALLYNKENPEAYISAVRDITSGHGVDAILDGVGADTWEANFEIAARKGTIATFGNASGPVPAFEPLKLSPKNLKVCRPTLFNYVATREERERYSAQLFELVQSGKVKINIHDEYAFTTDGLRQAFADIKSRKTTGKLVVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKY5</accession>
    <name>W3VKY5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKY5"/>
    <dbReference type="HOGENOM" id="CLU_1636117_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="162" mass="17437" checksum="8C78A96B95CF56A0" modified="2014-03-19" version="1">MLPSGSDGAWGYVAAAPEWTIAGNRHVVELHGRRAESKAELLQSEAVWRPADEFDPSSKQVGRFAPRITTGIRTRLAHCDPRWWMKKISTLRLDIQLLPFVPRPNTLCPRGSSLGPRRACLLGSMGTAAPSPGAEAVAEAAVDSISPTPPPDSFRSGLDDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL00</accession>
    <name>W3VL00_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL00"/>
    <dbReference type="HOGENOM" id="CLU_027723_0_0_1"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="527" mass="56715" checksum="EC5B1A331D370FEA" modified="2014-03-19" version="1">MYLFELATTGTISFGDFVSSAQLVSQVGEATQLRARVRAVLKEHRAGASTTRSTSSSKDDLRSGTDAEAIPASDWMRIVTALEEYLPSVVGVFNCVQTDDLLLRYEPVFSWRTSISSTRFRGPQRVELPGLHYELAWVLVTYALALANFAAATVHGLGAFERDRSLSADERRVKDERLRWGADTLCRASGVLVYVSEELLPQWRDAAGAMDVPPDLTGEATLALSKICMAEAQALAIRKLVSPSVASAVDTVTPGPPLPKSHPSVSLLAKLHLHVVEELESALGLLKTLKDRGGNRSGRRDAEGLSANHEHELARRVSATNEDLVPGADKKKMFGKLRLGKDKAKDDVPSATTGVGGDLDVSSSLLAHVRSSLTLHRALAYKWLGIDAGENSNRVGEAIALLTLSSSLLTPSSGLLKRKGQERVGVEAATVEHWLRAYRQLNDTVAFQPVPPVGEVQNKVPAGRAALASKKFNLPTPRFGPGSQGYTGRGFDSEALHALDADHPARANLVGLTTKPTDTYAGHGAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL31</accession>
    <name>W3VL31_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL31"/>
    <dbReference type="HOGENOM" id="CLU_013985_18_0_1"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="188" mass="21171" checksum="F90C5B2B75086CE9" modified="2014-03-19" version="1">MTVELGQNAAEPLSFSVRLGEETDAAEIAALGAKVFYESFAWSMPAQDMRDYLDTSYSASAIQLELKDAATYRFWVARDDTTNKLLGFVQLNRCSDEPCLTVKPPESIELQRIYTDTAAHSRGVGSTLMTTALEYVVAQKYRAIWLGVWEENPKAQKFYARNGFNKVGTHDFVMGSCVQTDWILERMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLA8</accession>
    <name>W3VLA8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLA8"/>
    <dbReference type="HOGENOM" id="CLU_013173_1_1_1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000054">
        <property type="entry name" value="Protein phosphatase type 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="58"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="364" mass="39102" checksum="38C080D365A9A597" modified="2014-03-19" version="1">MAARKKRQVDAESAPVTVAEGMHTHGVLNQHPNSFRSQGSSDGSGASKPEAPSGLAFRIGFAEDPNSRFRRAMEDAHAFVYDFGDVPGQGFFGIFDGHAGKDSAEWCGRNFHQQLLANISSSPEKPVPDLLNSTFHSVDKELANLATQTGTSSGCTAAVAFLRVEDDAGSKGDQASSEDTAPAAEGTTERAQSGTGLWGKISKRFESSDHAEQAQPRQAAKRVLYTANVGDTRAVLCRNGQAVRLTYDHKGSDAQEAKRITDAGGFVMNNRVNGVLAVTRSLGDSNMKEFVVGSPYTTETVLGSEDSFLIIACDGLWDVAEDQEAVDRIRDIQDPQQAAEKLVQHALSEFSTDNTSIMVIRFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLD4</accession>
    <name>W3VLD4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLD4"/>
    <dbReference type="HOGENOM" id="CLU_039329_4_0_1"/>
    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="31"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="420" mass="45711" checksum="32EC72D2C00B22CE" modified="2014-03-19" version="1">MDHLTSSYKSSAPPLSTTAIAPTTTMKKLLVDVHSHIYTTRLVSLLRSRSVNPRIHRESSDGTEKLAILPQEVAGGRTVGPQYWDVRNKVSFMQRHAIDVSIVSLANPWLDWMDAKQAVTSAQECNADLEEYCHQATQLFGDAKGSTIEPERRMRAFGILPLAQGVEVDEVVKSLDAIKGAPSLCGAILGSRGLGRGLDDPRLEPVWEKAAELGLVLFLHPHYGLGSDASQPDGLWGQQDNGHVLPLALGFPFETAAATTRLILAGVFDRYPQLRLLVAHSGGALPILSSRLASCVAHDPHVCNRLEHDPRYYLGKLYYDAVAYGPEELEAVAKIIGRAQRYGPGAADADVKLGIARMHFGTDHPFFPPTRNDGTVITDDQTEIWRSVSENVEAIDSVASWSDADKHAVLGLNAVSLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLR7</accession>
    <name>W3VLR7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLR7"/>
    <dbReference type="HOGENOM" id="CLU_017716_5_1_1"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="588" mass="64238" checksum="832AC52E7F729194" modified="2014-03-19" version="1">MHLVVGKRISLGSHRGTIRYVGPVPPSSGEWLGVEWDDPSRGKHDGTSGGTRYFSVRIAGSGSFIRPTASRLCSGCSFVEALRNKYVPPELPVQDQVHQSYSRKTIADVEIETPNLDRISRRAARLDRLRDVGLGGWQSGPSVEEQAAEEQYSVARAFDADKGFPQGAIRSTCPNLRWLDLSRSLLPDWEEVSLITAELDHLQTLLLHCNRLQPPPQPLPPSWSDRLGHIHDLRLDATLIQWDDILKLAPALTVLKHLQLGGNGITTLASPGAVAQSAVLPALTSLSLQENELASWADIASALSQLPGLESLNLNRNRIASIPPASTSAKLPKLKELFLRGNQLDTWTSLENIPSWLVNDQLEALHIYDMDESASANVGLLARYEYRDFRAVAIARLGSLAVLDKTPITPKERKDAELFVYTRFRRGDASIIEGAPADPGQSATLALETADIVARFPRFAQLAQQFEADTGMPARPAREGTTTLRSNMLSVMVIASPSAPAQCQPHVAQPQASATVRLLATTPLRIAKTKLAAAVRVRADQVDEVWALLSPPNAPQGADKIVLEIDDLSRSLDWYQVGSDDQIVLVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLV4</accession>
    <name>W3VLV4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLV4"/>
    <dbReference type="HOGENOM" id="CLU_006586_17_1_1"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="432"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="530"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="750" mass="83526" checksum="A377FE56C19C529B" modified="2014-03-19" version="1">MGQASSTFVNHAAAKVDIPGQGTLVGSVASDKTTGRLKSQRYAGIPFAQPPVGPLRWKRPQPLPATFRYDTDGKRYQHFAKACPQPTNYALTNGVTIPDAPVFAQSEDCLYLNVWCPVRDDGSRIDRKLPVLFYIHGGWLQIGNARFSPDGDPSDLIHKANLDAIVVTTAYRLNVFGFLAHDELRNEDPERCTGNYGFWDQRAALEWVHRNIEHFGGDPGNITVAGLSAGAHSTHSQLMHEFDLCARDPAYTPIIRRVFLQSNSAIWPSKPVDETRAQFEELAAALQIPAELSDADKITRLREVDGASLARVLGGMDMHTFRATRDSQPGAFVKPDWTRAMMDGRFATWAQKYGVRFVIGECADEEWVYRYINTPTDRASLVRQVHNYYTLPLVHKMLPHYGVAVGGASNEHERRQKDNGHGLASVGQGEASLYTTLGVRPSATSAEIRAAYLAQVRQHHPDKLQQQSGGRVISQDDAASVAESLAQSDELIRRLNHAYKTLVDDGLRASYDASLAAARAAVSASSQPRISATVDFESFQPAEHRDAITFSHACRCGSAYMLSEDQVHAQVDVVSCDGCSENIRVRYDDDDAQTHDMTPDEVGEVFGRICSDSQVYMAERMLVTDLIHGGLDPERVLRYRIDYRASVIDKALPGFKGVSHSFDDFVWWFACLEPGAEQENVAEWLQPYRAFVHGEDVQAQWYAGRKADARLIRTLHKDGSISVDVDQRWEENEHLIQAMLVIRQELAQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLY9</accession>
    <name>W3VLY9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03846</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLY9"/>
    <dbReference type="HOGENOM" id="CLU_008539_6_0_1"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="612" mass="65759" checksum="E3CBF2E85DE8CE15" modified="2014-03-19" version="1">MSEEKLPQPVSAGNAHHGHAHSSTRRRRFTKRQMLLEVLKGVLIAILLLFPSSTISYASDLSNGVWHWPWTPKHVKTNVILMISDGYGPASVAFTRHFAQALNGDNDYDSPFQLPLDTILVGTHRSRSSSSLITDSAAGATAFSCAKKSYNGAIGVTPDGKPCGTVFEAAKRKGLLTGVVVTSRLTDATPAAFISHAASRAEEALIASQLVGGPKNPLGERTLDLAIGGGGCAFLPNTTASSCRQDDEDTVQLAAQLGWDVRVGFPTNTSFSPEGADVFSTKHGREPTLPFMALLSAGNTPYEIDRLNAPQPLPLKPLKHYASKALELLSESEQNTDGFVLMIEGSQIDLCAHNNDPACHAREAIAYHDTIHLVKQWVRKHTSRTERTILISTSDHETGGVTLGRQLTPDYPNYAYYPQRLLNAKHSTPILTAVLIDFVRTEVAKAHGGAHASEKRVRDFIRHSILGASGLGLESDTQGGPPTDDEVEAVFAVVKEEILSRRHEELDEVAAAADLIRLVGSTAHADALHALGPVPGVNLDGIRRAISDVAARRAEIGFSTSGHTGIDINVYAHGDPTTVHKLAGNQDNTNIGTIIQEFLGLDLDAVTRDLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM01</accession>
    <name>W3VM01_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 14">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_03231</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 14"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM01"/>
    <dbReference type="HOGENOM" id="CLU_025879_5_0_1"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000275">
        <property type="entry name" value="Protein disulfide-isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150126" description="Protein disulfide-isomerase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="342"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS62594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="503" mass="54416" checksum="D31384AE7A25D359" modified="2014-03-19" version="1">MRFSRSAIAAGLATAATFMAADASSSSDVLDLGKDNFTSIVSPEPLMLVEFFAPWCGHCKALAPEYEKASTELVADGIKLAKVDCTEENELCAQHGVEGFPTLKVFRSGSASDYNGNRKADGIVSYMKKQALPALSTVSADSFAEFKAKDRVVAVAFLDASDDKNLAAVTAVANNLRDNYLFGVVNDAAVAKEAGVSAPAFVVYRQFDEPEVKLDAKTLSEEQIHNFLKAQSIPLIDELSAENFMNYAEAGLPLAYLFADPEAKDLQAQVESLKPLAKANKGKLNFVWIDAVKYSAHAKSLNIQGESWPAFAVQDIEQNLKYPLEDLSGDLVAKVSDFVDQYASGSLKPSVKSEPVPKDQDGPVHVLVADEFDAVIGDDSKDKLVEFYAPWCGHCKKLAPTYDQLGEKYKAHKDKVLIAKMDATANDIPPSAGFQVQSFPTIKFQAAGSKDWIEFTGDRSLEGFADFIALNGKHKVSIDLDPINATGTEDAAPAKEAPHHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM17</accession>
    <name>W3VM17_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM17"/>
    <dbReference type="HOGENOM" id="CLU_006976_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="735"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="986"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="743"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1235" mass="133026" checksum="EE1199A0DB7A3168" modified="2014-03-19" version="1">MTTPPTPHASSPSRRLPSTAHPSTFATGHTSSAASSRPSRDDATGLYDQSARTLDLQRRREHSTSRHEPGAYQPSSKPTSRSPTKNVASSTASTSSAARRKSNMNSDKAEKRRSSRACLECRLAKTKCHVTDNQDVCDRCAKFSFDCRFVRHHRGRKPVSKLAAIDPEDIDGAPGSSRHGGSHGYDGSDDDLATDHDSDSANEDIAPKNEQGPSGQDDADATHPAQAGRPSAREHDASGPASSDGAQRRSRDTASTKASSGRSNSKARVQRNANNLHELDTSARRRIWEMLAQKIPQRGSTYTFVSKGEVAHDNLQASTSSSKSAGIGASSKRASSPSSASALDRKDAARESATGSTAEDDPSRPSANDSASTQPKQASAPSQHFASTFRNLLRPVDKRAAASTAQEEAASAVAARYPRLPETLNLFGSKDPVDLGILSMAAARRLYAYYFEHLNPWGMNFDPKLVSHDAVRASSSYLYSTILYLASRYIELADGEDDSPAFFPPTFARPRPDDDRITSAISAQLGTHVRSLAIMAFALGDRRMETGVAMYLSSVWKEADDHFTILYCSYAAKIMSDIPTELLSLLPSSDAANARVKNGIKQKDDAETSAALQQQRSRRNQQRQFLFHFIQEHTHLLHFAPRPNFDRGPSLLRNLLAWADDALATEDDILLCADIDSVLLQTKYKSIMERAQAQEKDTLYGGSECFLLLQSFMDELEGWRSRWELQARKINERFGRSAAPSPPEHKSDHDAGAPAADKSENGNKRKEDEGPEDGVGHLPLDARMHLLSVMRSSLVMQVSSIAFRASLRDINKAKPAAAGKASSTSAFSPSALSAMDDRAEQVYYTCLDSALNLLVHTLQMPPSILRHAQDMIMVLAPHAALLATYLISLPLPSVPPHYAASAASDRMGYEYAKVKTRVRRRKEYERKCLELMRDTRESFRLAQVRADDHVGLCAQYFDSLLNVIEGESVENGASAAAPARQGRSLLSNTSVLAGTKRSRSSLDTQRGEGGEHEAPSAPRGVTQTASSDAAAGRSSSAGPTPGSRTSAQMGAQPHSSLRHSAQSHGTSNMDASAAETLLNLHSESHPFGSEADEAGAANEGSSRVFPAGGYYGSGTHLAHPRVGAHTASTPPSSTSAAAGSFSPGSFVSSGMFGHFVPPSSSSIPNSPQHTYPHHHHHPHYPAVAHPNAAEFAFAPGMVAAQGTATPTGAAGTGTSTPVDWTWLQSFLEVPEFSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM51</accession>
    <name>W3VM51_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232447_0_0_1"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000955">
        <property type="entry name" value="Related to negative regulator of mitosis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="6">
        <location>
            <begin position="77"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="7">
        <location>
            <begin position="1884"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2102" mass="227342" checksum="EAF5ECAE704EA95E" modified="2014-03-19" version="1">MPMTTMSTAQRISQHVQACSRPASDDWDPALVGETSHLLARLQKIRSRSSPTTEGSFTPSTHHLSPRSSSKRDAGEEGSGGAHDELHWKDNLLTWTRGGTLVRTLTFSSPILQAFWTLFHVSSPDNIEAAPGKLNAHRNTGPPAKALCVFFEQALHIHFPGLGEQLDMELPFRFSKAFPAPLGFLIQRQIESEDERIASLLHRPSLSAQPEITSSVGYPFPDISSSSESSYSFSQMLDDSDHASASQLRTDAARLLPMVFYLSRCHDDLVPVDRFPQLSFGLTPPDDPHPVSHGPASPFGELDENIAFVSSLDDARFPPFIVTTAQHDSVIRIYAFAARHTAFDATATLLSAPRLPSSLAPAPALSNGRPNAASAQMHAPSDQDGMQQPLFKPSRTVSDTPATKSLGRGFPSTLRRSARIDLERRTSGLTSAAGMGRDPSGRSRRISAMQPGVADRRSNGRKDDATTQARDRTLGNISHTADGLRLQSQTYQHEAMLEELGNAGTSMRIPGTQASAARIRRSSQTAARTPYNGPRTSNRTSSAAIKARPSMNLSRLDSSLDTGRMTSTFATGVAEHAMRADAADADAALNDDDDVDLARIADIDSFARGFASVCLLDEIKVSGLASHRHPAEIHVHTAMLDRLDSDAAYVFVSVPATNQTFCRRLGFQQLGPPDRARNLPFCKAPTKLQASSAIPCSALLPIQSISSESIQVLTISRTGIVELHFGPPSPARSPLDLTSFGPLAKAMEQIPGPVASLSSATTTPRARTLLLTSSGNQQQMCAGLDLRPRCVITARILATFFRTLPEHLAAKLAGKWILSRFLSVTEPTQRPSLAAAEEDWSAMLSCFRASSQTDAINSTAHRIFADDPLLSSLAPMPAKVDQAPSAPSNGAASLGLEPPEIQQAMLVLYLLAEETRLDTSRHSDGSIRIAGLAATLAAELGASAWIEALCRRFALQDVVTVYGSRPPVGEATKSVPPTDPYTIVLDMLSGKSTRTSSLSQWVSTSSKINATDRETAETFPLLHALFATYTAFSQGRRTAADVSADVVEAMLAHQLDLERLRRLPFGLALPLYQAIRCCQLHPPSGKSPEFYETIQRADIVLNAVPQQSALGDTSVRRIPAQLIRTLPEGAPLDAICAQLFSRDFRLRDVVALLSTESVNSVYVTENENQTEASINEQHSAAVAAVGERTKALSPGRAMLFMTSRPFLPTHWWRIPSICLAVKVRPRGMTIEPDAKMDMSGLDWPEFHNGVASVLELNVTADVKVDSKWIFAHLGEQVTARHAGFLYGLGLMKQLPSLTPVHVFRYLKMRNNLLTIGFLLGMAVSTLGTADPTARHLIGMQLTAFLPAGSAPLNLSIITQTAGLLAMGLVFLGSNHRWTAKRMLDQIGAQESPIANIQPQHREAYSMSAGLSLGLVYLGKGRGDGVKSLPDKRIVSRLVQLVRGGKDSAAGLSLTEPSRQEAGSCAVPELNLTSGPAALALGLVYLRSGNRAVADVMAPPQSTAELDELRPDVLFSHVLSRSLILWDGIDATKAWIQGVLPAWMQERIATGKSLSEAAQLAQINMQAGACFAIGLKFAGSKDSKARDCLWEEVDKLERQTRASTVSFFGRIRKSAVRAALDQVRISLGMVLAGSGDVTVLRHLRRAHGEVEGDTCYGSHMATHMALGLLFLGGGRYTLGTSDLGVAALLISFLPPFPRTSSDNRAHLQAFRHLWYLAIEPRLLIATDMDTNQLVSLPVKMSGVEGVSTQDGAFTPLLLPNARLAGSIQTATTRYWPTSIESKARATNAAPGSAAVAGAPSLSTSQILYVKRKMAHLDYLADPHGSRSLASAPAETSAMDVSTDALELTGTTASELREALRGFAPVGRHEELVRSVSQLSSHDNREEGRQVVSTASLMRSVVMDCLSQDKMFVLPLYTTLMQLRRVEQADTPTWRKHYRDLRLADELYRHHQRRIFGDGRDDGSHESMALVQPGLVASLRRRAQQHAQTLFEQEASLRQAIVEHLSSSQHQDGPSQDADGFWLTLLASEVPEAEEVRALCGSMRVFMTSLRNAADSGDEAQATARAEAGARMVADRAFGGAGQAPWTTYMLDELIGHVARSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM86</accession>
    <name>W3VM86_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM86"/>
    <dbReference type="HOGENOM" id="CLU_808921_0_0_1"/>
    <dbReference type="OrthoDB" id="2546643at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="36102" checksum="D5C512DF413A297F" modified="2014-03-19" version="1">MATASASTRAPPNSGGSSNPTGAASSGPSVGAGGPASSSGPSKVAPAGAQQPQISLLGTLPLHLVPALLRRIETLVTLAPEVLCEKETVLARHDDEASAVRETGDNAWASVVKARRGVKLRVRETARSNGHTECTLCLPLPSLPERQYPRASVRPSYTVEVLSDTSGAAQCKAGDPLADGVLNFDPESLDTDTANGWKSLVSALGWRPHFALLRYGLAYTLNASLFRHSSTATPNPLNPSQHTRYTLNVYRIFTPDPSGYTADWTPLDPQAATVVVELIATVGAQLDQSHFNHHCVLPDPAATPTATGGLDPDSTIESAIEFADHVAKHLRGLVDLRREAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMD7</accession>
    <name>W3VMD7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMD7"/>
    <dbReference type="HOGENOM" id="CLU_307174_0_0_1"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="8">
        <location>
            <begin position="371"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="802"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="106342" checksum="93EA579836EAEFF1" modified="2014-03-19" version="1">MPAVKRKAAASSSAAKKPGKHSRPSAARAPKLAQQLDMYIRRSDDESEDDEPPAVKQTNGTTKAKAEAEAEYEPESDEASDVASDDDVDVKTVSASNLAFLQGLDSNKAINVSQKDAKQKAKELKRSDRKAFDDERRRVTAEKKARLTQPPSDDDDDDDDLDSDLMDDIEDEPERVMEKKNYQEYSDVSEGEEVVSEDEARKRPTKSHKADEDAEAAYMARLGKRKQREQHQREQERKLRVNAKLPVRKLDGDISDDSDSEPEDRQDSEPEGLGSDAGSESDDDRAQNSRAVHAPIPRAASPSDDETAPSTSTPVVHSSITHSARFNLTAPYEILLTSHACRLPPAPASRKAAPAHRAAVAAAHKQTLLLARNQIASLASQIIADPEVNLGLLRRLAVFAGPTISAPPEKIPEIRAEQAAAKAAGSKSTARPVKIEVAPAIRQLAMVSLLAVFVDILPGYRIRSLTEKEQDDKVGQEIARRREYEAGLVAVYRDFLELCEAELKAANAGPEEKVKPGVGKLEGAAIRVFSTLAVRAVHFNFRQNILGVVVARMSRRQWGEEELACYEAIKTVVLGDLTGEISLEVVRLIHRMTKERRFKVNSRVLDVLLHLRLRDELGSKRSSTTNSTDPEKDAARAFKEAEERRAAMKAREKRGKGGKAKAREVRKGAAVHLSKKQVKKQKELRAIEDEMKEAEATVDLELRERNQTETLKLVFVLYFTLLKAPVGSVAAGVLESGMRGLSMYAHRVNVDFFRDLLKVLKVHVATNAALLTTTNDDSDSESDDENILLDQSVLTRVIRQIIVALKTTFDLFLNQAQGTILNLDLTDMLSHLYYVLFFLPFTSGDASDLALDTIYAILVRSASDQQVQAAFAKRLSVVALQMPAAMAKKTLGIVGHLIAKNSANAALLDLDDQSRNGTYNADGANLAATGVLESGQTVLWELAHLTKQSNAELAHKARDVWALKDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMF5</accession>
    <name>W3VMF5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMF5"/>
    <dbReference type="HOGENOM" id="CLU_009834_6_2_1"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="308" mass="32984" checksum="049DB8F0CCF24912" modified="2014-03-19" version="1">MTSKFTSPPPVSADSSPVALSFPDNCDGRVAVISLNAPDKLNALGWAGYKMITRCLEWIAQQPELVVTIVTGKGRYFSAGADVKDPSRTLPPEVEKADPNTEEGKAVIGEFYANRANAGQGRLASALRSHPKVLIGAMNGPAVGLSAAILGHCDLVYAYDDFFFFTPFMSLSLVAEGLTSVTFVQKMGLGRATEALLEGRKMLAPELKEAGFITRLYTKPAGFDGKDKLATPPILDDVLANVREKMLPPNASPFSILYTKKLLSDAAYNYQGVDAANNAELKGAEIVFASGAPQKRFERIAGGARHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMU3</accession>
    <name>W3VMU3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMU3"/>
    <dbReference type="HOGENOM" id="CLU_118853_1_0_1"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="122" mass="13694" checksum="CF74AEB115A4077B" modified="2014-03-19" version="1">MSVEAKFNKAVSIVGSLPKDGPVQPTQDDQLKFYGFYKQATIGDVNTKKPGMFDLTGKYKWEAWNKNQGMSKEDAQQAYVDALLQLPLCPSRRSSYIAIQQILKKHEDEGDSAQHIKDIESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMU9</accession>
    <name>W3VMU9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMU9"/>
    <dbReference type="HOGENOM" id="CLU_049918_2_1_1"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="369" mass="41482" checksum="29817D7C44157634" modified="2014-03-19" version="1">MVMRPGLVDSALTEPQARAILHTIRFPGFEDEQSASSASLPAATLSTLTRLQIHFLLSFPFEALAMNYEPGASMAATLEHTYSRFIEQRHGGGYCLQVNLLYRELLAFLRFRFIGVLGRVYSPISGTWTGLTHTASLVYLPSHLEEGKYVYYMSDVGFGSSPHRPILLRDGWEEFGRGSDKFRLVKLKIQPRSYLEPADDETDDEVAEVARTQVVWKLQNRKVGKDWEDCYSFSTTQCFTPDYLASNCATSSKTAVPFASMILVVRYLLDPTRLAESAQWIARDGLDPDLYAYHPDCIEQRMVVGDKHIVKLGDQQTVFRTIESEQQRIELLKSDFGLLPHVDTTAALHEIRGKPSALNPLPNGEAHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN31</accession>
    <name>W3VN31_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN31"/>
    <dbReference type="HOGENOM" id="CLU_376521_0_0_1"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="697" mass="75903" checksum="015EEFEA764CC9E6" modified="2014-03-19" version="1">MPPAHRGPTGSPMDRWTDASPSAISSGFQTAMSLGPQPRLNFDMPPSGLNTSAASFNTDDEDEDEDEDDADATAKKADGKPAKGKKGAAAAKSKDAKAAQHRKEQNRAAQREFRQRKQQYIRALEARVELLSSDHDTQVNRLRYALRHLLAENNSLRGIVGSLAHFIGARSIGGCLVEAGMTRQMLEATMNSSSEKTMSEAWANWPGAGECEMLKQLRKESNIPADGLPESKLANYFRDANGKAAADNSTDADKKKRTADDTAAKDSKRKRKTNDTNASRNSSPATNPDPRTGSGQPSVASPQSMASNEMKHQFWQPTAFGGSLSMRNDVDSMFAQTLLGGGNADMSGLAAMTGSLFPTDSQSVFSPQQAMAFNNIIPTPGSAMPNTSTAAPNFNFLGFGGVPTMVGASADSTLGSAPFATQPPPPGQSDTTAIVHTPASPATGGVEGTVLRSGTRASPEQIRNLRRRSARAIAQVNRIWAQRGANNFLNLPVQYPLDEQDLKFLEQQEATNPHIKIAYMRLPNEWDEGDIAGGNASGSPDGSQTKTRYDIEKQAEYFLQISYHLHNHSLNPSYSLPPSLRPTALQQSTPHDHAIDLLPNAPLRDKLIQNPGLETHNVVIDVIRFLSPSDGDMNIERNWVLTLPFFVRYPQLADPALVANMNRQRAMRGEKEVTIDDIWREHRAFTEYTQARLKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN59</accession>
    <name>W3VN59_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN59"/>
    <dbReference type="HOGENOM" id="CLU_136349_0_0_1"/>
    <dbReference type="OrthoDB" id="10303723at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834378" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="149" mass="16155" checksum="55A58155B0B590DB" modified="2014-03-19" version="1">MHFTSLAAFALLSLAGVQAQSWPAGPPTTAGLRESEALVSSFCSGPPKGKEMAYACFKINGDIRKHMFSPKNVIGYYNRAGDTFVILQQPGEQSFSTEIDLVTINAPLKPRCLDVLIEWSTPITKNEARIDSSYPNACPGSAPIQLHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN62</accession>
    <name>W3VN62_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN62"/>
    <dbReference type="HOGENOM" id="CLU_025224_0_0_1"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="551" mass="60155" checksum="1DEFA996D2D9B713" modified="2014-03-19" version="1">MSGSGLRVQIASYNANLQGAETTRHDLTPWLIPAAEQRPVQPVSSKPVTNANVLEAAAYKSSNAKTPSTHPSLPREAPDFYAVGFQELIPLHTGFAASGHVALYNTDLDIRRTVRPHQAVVSGTGMYASLEEGGGPEGYPLLCRVDLVGIALFVYARERAAFSVSKATTTSARSAAHRVKEIRAAKVGTGLAGVMGNKGGVGVRIVVAAADGKGPDEVLTFVSAHLAAHDHNVLRRNKDWQQIVQRMVFEPTSVQKLPILQEQSSKPLNPNDMDALKRQHEKETQPDKRARKTAPLDDKSYTVYDTTHLFVFGDLNHRIALGKSELERARKGDEKAGASSELTKESLFKALEAGDWSTLSEYDQLSYQRLSQPPKAFHGLTELPIEQAGVPPTYKYVVSRPGKQTKKKNAGITSDALEGHTLNKKRVPGWTDRILWASAPARDQNAQHGVEVEFYRSIMQYTHSDHKPITTLLRLPPPGSSPQLLSSLNPYETLPSTQRLLLSTSGVVLDRLVGYIWSLLLLAGGGSLAGGLLEVFIIGAITAWWFYQPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN95</accession>
    <name>W3VN95_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242401_0_0_1"/>
    <dbReference type="OrthoDB" id="2556075at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1635" mass="173754" checksum="E515AA2EDBF88571" modified="2014-03-19" version="1">MASTSHEEQVLYQSKHRRRGWVIASEDGTEIERPTSFDPRRSAAAWNKGQGPSQASIPSRASSLAPPSSPTAAAPSLPRNVPTNAQPTSGQSVEKRSPPLTRRSSSTSDHDRGASNGSTELDAQAESSSSGRRRPSPPLLVPPKQTYRKIPSGRVLPPSAFTDHQKLLAGAARPQRSGAVDRSSSSTSSSSSPISSAVSSQPRPPVLKANLGLRSDLALLAAGRRAANSSGPSSAATSSYTPDHTASYSSPASSVASTSAAYQYSAKGKKPATSPLRHDEEEFFSSGTEQNPAIVVRPPSLPWSGTQLNSSGQPSLLFSPGPLPPLSEKSAASDVDDVLSSTSENLTDSEGTAGSGARPGKRRDSLRIELPPPPAQFKDRYPSIMVDSTHASDSEASGTSTGVQRRRRRRSTTSTQLLGVDAEDDDEEFADDDSSWPSTPSTTPLENYFAAANPRSKPSRKAFQTTKEIIAPDSGLGMGRPMVVVTSPSTASEVSSDRRSSSGSGSNSERAMSSSPPAAPIVPPVPMLSKIEEHPVQKVAPDAGPSAAPAPRRSLSFELPVARMTRSSADLVSGAAAVRSPSRAMAFLAKISPNRISNRSSTDLTSPVRSEDTADPATAPTSEGQRRASMEPRRSVELRPILLNAASRPKPRPLSSDEGPRRPTPTTSAAFAQAVQQRRQSSGRIPIRPNVVPYHSRRSSELSDASSNNSPLLHNRGSFDKDLADPAYSPLSQNTTLTMPSPALSTDQKPFSYHSSGAERSSGESIEPRVASARASQDQAAASATYLPHVNKAERRAASQGETEARPSAIRLLVDSQKGRMSRDNDSIAEWISVSVNDLPLSDQGHSYGNGGAGEFSNEQQKAGKKVLKNKPWKLGRFAASEVVLPTKVASSSAAAPSAKTSVEAKRRSVSLLKRASSAQVNETPRKDTGAAPVAGKGPLPLMRNLGFTTANRNVVLQNLCAERSISALAASTIYIAGCGRIDVPAPQIVPATKQKPKTKPAPTPAKRAILSSGEPTPLPATKAQEPPKAPITRAEPAQEAYLNVKEGRHVGYSLSGAGTGTVKSMIPELGDWSGSSGHYSGPDEDEEHVKPFRDYEDEGSDLFDSDADAESSVSEGEETYDEEYDAEVPVRFGQRFSAASKATPEVVSPTRTATARNELIQQQRADMPIADAGVDKVAVSPSLERLAPGKVVLRSAEMRLCVKDDDATSAAAGVQHYWKALQVQKVTGGTGNEGQQQVRKQPSSRAMKLEQEVAMGIFAGFVGNRSPKRQAQRSFSSDSGTSDASAQVSGGKELLISKMDHSTFSVRALPGAIGNRHEQVLEVVCRSTAAKTKVELAFPSPLLSFAEFAHGRSRSGRSEGSQASLGDKEGTKQRLTIHVQRQGGRGFAASFRAQEGQHWTWHASKLEASVLSRPQDSRTKPLLAVLDNYDLSLRTMQEHETVELATYSTESQVRNALGMFRPRTKSGPKPMPEDVSQVGPAVPPPAQVLPLAVAHRGFASPVGRAEVPIPRRGIRGGPLLRPQPHAAASAARHHGLWQNQRAAISTEAVVQVHNNAVNNARASLQLEERPRLVHAPTDNAERLQAWRTAATGQQDAITAGDKMMGELTFSSHAAAVHRDLVVLTLFAVLGMAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNG3</accession>
    <name>W3VNG3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNG3"/>
    <dbReference type="HOGENOM" id="CLU_150144_1_0_1"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="89" mass="9513" checksum="14819991D240206C" modified="2014-03-19" version="1">MSNRAAGGLSLFAALALFALYTLWAIVLPLLPDDLAIHAYVPDRRWAVTAPSVVLAVGLGTVGIYIAALLRKDALQDLQAQREGRILAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNG4</accession>
    <name>W3VNG4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptide hydrolase</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_03384</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNG4"/>
    <dbReference type="SMR" id="W3VNG4"/>
    <dbReference type="HOGENOM" id="CLU_015120_0_0_1"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000097">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053974">
        <property type="entry name" value="ERMP1_1-A_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22249">
        <property type="entry name" value="ERMP1-TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="234"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1/1-A TM" evidence="17">
        <location>
            <begin position="509"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS62307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1024" mass="110499" checksum="FB6641616AD18DC5" modified="2014-03-19" version="1">MPSKRKASTPKKAAPAPSAPAANGTRAPMPAVSTVNGQPLPAGSRAAATAADLRRYADARRARQIDPLDYQRTPKSGLLVLVVLGLFSLLGSITLYLHYKLPTPRGPTTILAAGVTPADAAAYHPAVPGVVPANAAAGSANGKFYELFSEANAVGVMHHLSVDVGYRIVGTKEHVEAEDWLEDVLRRYEGSHDTGTPDAPGRTHVEVFKQIGDGAHRFDFMSSTVWKRYYSMSNLVVRISDGTEESKANSLLLNAHLDSTLPSPGGADDGVGVAILLEALRVLTLPNTGRRLYNSVVLLFNDGEESLQDASHLYITQHNQTNAGVKAVVNLEACGTSGPELLFQATSQEMIEAYSHVPHPFGTVLANDVFSTGLILSDTDFRQFVEYGDKLTGLDMALVGNSYFYHTRKDIPKYLEPGATQHFGENTLAIIEHLCLKNGSAELLRNIEPHQSRHTLPIYFSIAGRYFVMLQNKAFKSIVMGLSAFINFQLSSTVRTEANIGALNLTILSAVAAIVSMIGAALGANLVAVIMTRVLGKGMSWYSHEFFPMLLYGPPAIAGVLVVQLLTAKLIKPHKRPYLERASLSGLGIFFNLGLLGLNAFGIGSAYLMMLASITFTVVVTINDFVLIGVGQIEEKLVAPDNRVSAYVYPIMALIPGIVGVEGMASFLDLFVPLTGRMGEISPADHIIASIVAGLSFLSFPFAIPLAHRYTAENLKKTIVALLALTAAVMAVFASPGWKPFDSAHPKRLFVHQVENITSGEWFMNVGAADPAPGFGKLANELQSYLGVASESRAELQVMNDYNSDFDILYPVSAFLTPYKFQLPSPAAGFATKYAAPAPEANHFTVRAANEVIDLEAGTRSLTLEMSHPGVIWSVVAFDADILSWNLPSEPPKGHQRHHLKSVARHGIYSWSVDLVLRLEGDALEAAKKRSGAAARFKKAVTGGDSEGKLIRTNTDAAVDKDASRLWIDASGLVADEMYPQHKHVAAADRPAMNTFVKMDDYMLQKHPEIDVMMLTVVAGVFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNJ9</accession>
    <name>W3VNJ9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C6 transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNJ9"/>
    <dbReference type="HOGENOM" id="CLU_081928_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="225" mass="24557" checksum="4AE0408AA4C81A22" modified="2014-03-19" version="1">MSSSKEGGGGKRKRVSRACDQCFLKKDRCDGELPVCTFCKQLERTCTYLRPERKRGPTQGLRPKLEQHIAALEATLGFVLAQSHASVDVSALQTASDAQRSVWRQEWLSHPVCSKLGLSDTPSPVKKEDEEHEQESDVDLALPPEHSAAVREADEVAREMPLSSSGKGGSSLRGLVPRGTDPNAALGGFEIQFGGNQTDEDWVRTFTRPRHSSSSSSPPPPPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNK3</accession>
    <name>W3VNK3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNK3"/>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="340" mass="36581" checksum="16B820496AFC5AE9" modified="2014-03-19" version="1">MPSFKASDIPDLSGRVAIVTGGNAGLGASSCLELARNGAKVYMASRTESKARDAIEKIKKAVPNADIHFLQLDLTELAAVRKAADDFLAQEKRLDILLNNAGVMAMPYEFTKDGIEIQVGTNVVGHYLFTMLLLPTLYNTSKLPEYANPDSPSVRIVQVSSMGHLGAASDTSFKDLEAVNKKHWPEFKGTWNRYGKSKLGNILIANELAKLLPSDARITNLSIHPGVVATELLRGPVASYGKIISLVQPLYNKIVTAPEDGALTQLYACTSPQVDKLGLNGAYLVPVAKKGSKSKQAQDKDGKLAAELFAFCNKFVNDKLGLDLAAHVQPAGVQLPQSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNN2</accession>
    <name>W3VNN2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNN2"/>
    <dbReference type="HOGENOM" id="CLU_052827_0_0_1"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="263"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="366" mass="38695" checksum="3361E89FEA4582C6" modified="2014-03-19" version="1">MRPVTISTVPLRQLSAGLRGPRSTSFPPSLAPRLPHASPSSASSTPAGAAPRRPLSTSPAPRAAGSTFVKATIALSLVGISSYLFGSLYPPQMLKLIFKPATPPRLRSDGPEAEAHTREIEDALHSLAIVKQLKSSSVAHGSAAELEVLRSQGKHITDIDESTTVEVPASGRIPGANVAVSGPPVEGGAADTHQYVMTRPYLKYSREKAQHNLTAGSLRGPGMVAVPPLVFTKTGVGAEQLGGAEGDSTILLHLGRSVCGHDGIVHGGMLATVCDEALARTAMYNLPGKIGVTARLEIDYRKPTMAHQFIVLQTELVEKKGRKAVVKGTLKDVDGQLLLECRAIFVEPKYARYFLDAKGIKQAIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNW8</accession>
    <name>W3VNW8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNW8"/>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="352" mass="40333" checksum="2450960F5D8D4263" modified="2014-03-19" version="1">MAPTATATANIVVPEAKPVFQAANPKGLADNVMKPTKTTYGDWRNDFFRDGYVVLPGVLSSEKAEHYRSKLLDWITGFNLGLDLNDESTWTQEHLPQSFKSMFLNYCAPHERFMWEARCEPTVIEPFAKLYGTDELLVSFDSFNIGLPRRKDLTFKPWPHCDQSADRKGLACVQGILNLYNSGPQDGGLIVMKGSAPLFEEFFEQLPKEKRFFSPHVHSDFYAFNEEQVKWFEERGCTQYKVEAKPGDLILWDSRTMHHAAFPMGNEIRTVIYTCFAPASQISPEDLAKKQELFNRWEGTTHWPHCNMFGQGKAKKDGKRESEEICPHERDEPIEKPIITEQIKKLAGLIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNY1</accession>
    <name>W3VNY1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HSac2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNY1"/>
    <dbReference type="HOGENOM" id="CLU_387842_0_0_1"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSac2" evidence="2">
        <location>
            <begin position="422"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="712" mass="76763" checksum="E5CF43D9E27DCF99" modified="2014-03-19" version="1">MPSAFRHAISADIPASRDGTQRLGFATPAPVAPPMPPAPASRSLFGDTVQPESLSLFSSTSSDPLALWTLHRDTELAEDSGVQILADATDAAAPSDLEEATSGFKLRVEAASRGTSIETVLHIQSPAIRNTFIRSPPSLEAELGIKLPHISFQFRSIGNARPFAFEVGIKDRIGCSGIVRLSSFQTKPKLYLPLASSATAGPSEPMKSRPSRPLLHLPLTTAPTPDQDEATLTAWQVVTLPLDRIARSLSDTSLLSATPQDSRPSHLDPFGEFDSISFCTMSAQHEPPAASTQEKVATAVAPPSAARTDVAARAEETSAVRFVLTDKALDDAFNDVWANNANAISHCYSNTDALKVDFTRTGKRSFLGMINDATNSVYRMVQGAVTDFFRQTVLDFTYGSIGLHGLERYYDDLNSRDPSESIRLARVRTSAIESCRREVVPDTEPLIGGWTLCSPLQPNTVQALKLEEKVALLTSKALYVCSYDFGSEKLNEFTKVLVGDIVGIQEGLYVTSPHESSHPEDNWGVVVTYLNSISRSNTTASIKNLTTTAATASSAHAADAARRIFAFRAISDEVEDAAAADSSATMRSRHLYHTVKGGSLGTAPSNRSTAAAAADDDDDGPVSSKRKVARIVELLCECCADAGAYDPDQEDEEEPFVTSKTIQRCAPASSPFDIESTILTHFFPASYSLDEAKAMMPLFGPLIEGLKRRLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP48</accession>
    <name>W3VP48_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP48"/>
    <dbReference type="HOGENOM" id="CLU_1595240_0_0_1"/>
    <dbReference type="OrthoDB" id="10685528at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="167" mass="17873" checksum="BF4A8CFE35B8863A" modified="2014-03-19" version="1">MPERAPARLAASVQLSETSLADHAVPHPNNPGTEPWLAATDARTPLDNAAASNGLNGTAAKLYTSSSILPAKPVDGEWGSILSILADNGSMTEDKMLVFPSTGSSSTFPRIGVQYDPIRLNPIQALITDQRPALALISTHASNRRRRLRRRSWSLVLAHIALKTACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPI2</accession>
    <name>W3VPI2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPI2"/>
    <dbReference type="HOGENOM" id="CLU_014819_2_1_1"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF7">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150162" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="610" mass="65990" checksum="4B51EC67489186F1" modified="2014-03-19" version="1">MLLLVAQSFLVIVLVRARLTGAANASLAELCKVDSLRNVLPTNGTLLGINFLPESLTAQVTNTSVGSGTAAGPSVSVASDTYSYCNLTLHYVHAGTENRTIRLRFALPAPSEYKSRFYVGGGGGYSLSSDATGGLAYGAASGATDAGYDAFDKSLDQVVLLANGTLDWDSVRMFSHQALGEMTLIAKQILPSLYGSDTDSSKVWTYFSGCSDGGRQAMSQVQRWGDLYDGVVAGAPAFRQGQQQILHLYPAAIEQQRGYFPPPCALQKIVNATIEACDPLDGRTDGVISRTDLCMSRFDLNSTVGKAYYCAAETSTSLGFGFGRRQLAAGSQTDSLPEQNGTVTVNDVMIARAVYEGVFTSSGKRAYLSWQIGSDLGDAEPTYDNATSSWVLNIPSTGGVFVRKFLERLELDNLDDEAFVNITNDQLVAWMDKGTREYYDTLQTTWPDLSTFANHGGKLIHYHGESDNSVPAASSVHYRQSVASSMHADLDASQQEERLDEWYRLFLVPGGAHCSANSLQPNGPFPQAASLMHQIIDWVERDIAPAGLNATVTQGGSDEGKSVSLCRWPYRPVWSSENATDINAMGCEMPDTEARKSWTYAFEAFGYAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPW1</accession>
    <name>W3VPW1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPW1"/>
    <dbReference type="HOGENOM" id="CLU_016785_2_3_1"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="127"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="405" mass="46708" checksum="8E3DE6EDE66867CD" modified="2014-03-19" version="1">MGAVEDEVVIRFETAPSYREFFERCLVANRPCILPRSLISHWPVEQSRAWASPHDGSINWSALKLRYGSQTAPVVVIRTNAHGDEKEDRQEMTISDAIDLILAHRTDPCNIKAIYIKDWHLIKQLHSDASGARDPYVVPEIFEDDWMNNVGAGGDDFRFVYAGTAGSQTLLHRDVYTSYSWSTNVVGRKRWHLFPPRVVAHLRRFPAVETSPMVPDIQTLQNIIDAATKGKEYSELHKAWKAVQVVDQQEGETIFVPSNWWHEVHNVGECISINRNWCNAVNVPSLYRSIEAELEHVERSLCDVHEMLQSNNTQGEEWRKEFYTLVQDVAVQDAGWAWDGFWKMVLRNLRNPPTGSRCRPDAKWVRTRILPLAQQFETRQDAHWLDASILDTARRCRQLLEGHME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ67</accession>
    <name>W3VQ67_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ67"/>
    <dbReference type="HOGENOM" id="CLU_009572_0_0_1"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="147"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="585"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="711"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="209"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="862"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="896"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1017" mass="108147" checksum="7D885C9E84FA2D15" modified="2014-03-19" version="1">MSTAPQSDAVRQDDPESAQPEALESDTQLKRMDPDSILADEADPDQVLGIDSSSDAAVKRASAFPLPSHADQSDLKRASAASAIFSQSDSINSPRAPARSISTEQHAIPEAQPLPTREELQAQVSDLTNQVTGLNEKLVKSFNRIADLEDDYSDAQENIRTMAAKIKELEKERAEHLDALNTGLLVEKAHVSSEMQRMMDRVIEETAQRGKAESDKSKIEAELDELSSSLFSEANKMVAVERLSRARAEEKSRNMEERLKDTEGIMLEQQKVLADLQRQVEKLQADPASKKFTADTASVASLESDAVSFHRLNTSSLARSISQRTAVRELKHKPAADLAAQARLIINIVPYQEFRSFIAHLRKLRKQLAPFYNYPLPHGARDSLTGTPTPRTASPAPQQGSSAVAATTNSIATASSAYSQGIGGSLYSSSPFAIAGVSRHRDYPTLPSNVDNMVSLPNQLSLPFIKRSQEEDVEPCLRLDFAPGLNWLSRRQANTAILDGNLVIEPIFSGSTTVDEDRIRRENAHLPPAACAMCGIPVVNVPLPGGVAATAMSSEQGGKTSLVPSSIATATSSWASSAASSLGSITGSSASSGSSSATITPKPSRGGLFSSFRRSSGTNKATDTEATATATASTEATDAHVDVPVEAMVSPNLPVPTHIFRLSESAPTRYLLCPHHCLLRLRAACQFWGFVRNLERSVVLEGKFMNDEPHPLAASTPSLDLPKPLDVPKSEQVETLEKAVAAAETEEESAPVAEEPAAAQSETKDVGDADKEAGADEKAEAEKVKESVQEGSDASDAPGAASEDKENADVKGKAASAAEDTETSEAKDKQDNEETDEAPAEATTKHDDDDFADAPSSPTEPKAPDAPEDEQKADEATDSVAKVETEATEPAAESDPTATADASNAAAGAAEGSDAAAAPAPPLPPRSVARGTGSVSPAPAVPPRRHPRAGALAVPPQRTSSASASAPVRPATPANTVLFLDRLDAMEWEDKMWTELTKLKEELWRARIGLVTDDTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQA6</accession>
    <name>W3VQA6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQA6"/>
    <dbReference type="HOGENOM" id="CLU_1993582_0_0_1"/>
    <dbReference type="OrthoDB" id="10606563at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="125" mass="13485" checksum="52DB876503124AEA" modified="2014-03-19" version="1">MSSPVPLRQRAKMQDLPTLVREQQTASRLCPTMDAFRSGGEHGVVMAPAFMPAERKRRPRRSGSEATERRAPRTEQGPTKPSQRRGGALSRVAGHTAGPGQTQRMFAGVQTERAASCVTPSCGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQI3</accession>
    <name>W3VQI3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ino eighty subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQI3"/>
    <dbReference type="HOGENOM" id="CLU_337106_0_0_1"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="829" mass="91137" checksum="D0FF04EC38909435" modified="2014-03-19" version="1">MADDPRADADGSPAKEQPSQPPVLQIVRSNASNLPRNLPVKRYDGDPLGRVEVQHALLCHLFSDTRRVFTNPRPGDRSTALTSGAGSAGVPAPVYPFGMSAGCVRRSGETEEEYNQWQENRQRYLLWKKRLDRKRKLERKAAAAASAETAGDSANDDADANNEEKDELADAGNEEDAAEPKADEGDEDEDLGDPNEPLDEDEFPQPGAAKLTFKELYIESLLNSSKCTKSMRDKILADEEYAEDFAKVCLLVNVGRINTTLAFYPEMKTVLRSYHPLPSLQNNENTRRNMQDAPRMKSLLKGVLIDTERPAPPTAGPSAGQPVKAQKPNALSEEAPSDFKEVIKRFRAGTVPPTSVVTLIFLLSLHANELTDMHFPVPHDSHSLFYPHADHPLPSKQRAEAFLWLLYHYLEGPATRPPGELPNPFDDETSLNAANDAADAYANLLTDEERKKRANQPWKGIANPAWKKWKQAQELDGAADDKVKKENGDEGGEDTKEPPVYLHRLLVPTLQTVTPEEAALENVNTEDEIKWGKQMQSERAAFLSKFQEEEAAKNAASTGSPAPSTGGAKKGHRIGGAASAAADRASAGDADTSRLKRRHGGAAGDVSKRSRMASPIDFDDSISDAEAGSTAIATSANPLTSDPYLNANVAISDRIRPALWDLDLSVPPQHRNTESLPQQAWARILERAQRGVGDACYESDEDDFALEEAQEPERSRAEICRILTGLRGVVRHDVFEADNHAVRLKYGGYEQEYNSNEGALLPYAKELETRSNRVDLYSNSTPVTGRRYDGDDAARRTDDVDDIEEALLGGEAEPRRRSVARNGYSPVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQL3</accession>
    <name>W3VQL3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQL3"/>
    <dbReference type="HOGENOM" id="CLU_026803_0_0_1"/>
    <dbReference type="OrthoDB" id="425936at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957">
        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833483" description="Phytase-like domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="3">
        <location>
            <begin position="77"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="513" mass="53864" checksum="8AEE0E8774B08AE1" modified="2014-03-19" version="1">MLSKLFLALPLASTLLGSASGAAIAKRGSGVDPADFSSEGLVAIGQYSASLRDKNGETIGGIGSAGGLVPGKFSRSGNTYSGQLYLQPDRGYNVETTIDYVARHHTFDFQFSEYTGSSNLAFSQASKLFNITYRDSLFYHETNGKNTTGLDPTAARTGGLSGSSSSDGPLGAANTPKSSLALSFDTEGFSANPDGTFWVSEEYTPGIYKVAADGSIIAYITPPEAVLPRINGKYNFTSKATPDSGRSPNAGFEGMAVSWDGKQLFGVLQSALVQDGGDGAPYVRIFEWDISSLSGVTTYQGGANPGDGVKLIAEYAFKVPTSSKGKARNVNDLIYLGHKTVGILVRDGNGFGSDDSGVNYKRIDILDLSTATNLAGTKYDSATGAIAPGGKLASGINLAAYSSLVDYTSDLSKFGMHSSGSPVDPTLLAAKIESLILLPTLPASDNDSSFDPDEYYLLSLSDNDFQTKDGYMRATGAYSAAYPQDVPTQLFVFKVKLPGVNRSDMLGRLGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQQ3</accession>
    <name>W3VQQ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQQ3"/>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_1"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002814">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="121"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="130"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="744" mass="81858" checksum="CD3BE658473EBE7B" modified="2014-03-19" version="1">MLAPLLDALRLTHARHCKRRWELLELGSGAMLRSACRRAGPSVAGRSSVAIAGPSARPSARAADVSVPSQPSSSHLHRFPTTRISAQSRRISTSAPRASASSSSGSASKAAARDFSQFDRLETRTFSIISHVDHGKSTLADRLLELTGTIPQDGSNQQVLDKLKVERERGITVKSQAVTMVYDYDGPRDDFISAFDDGFAPKPGRYLLNLIDCPGHVDFSYEVSRSLSACQSALLVVDATQGVQAQSITVFELAKQKDLAIVPVLNKSDLPAADPDRCALQMEEILGIDTTLPGQEPLLISAKTGRGVDSVLRALVERTKPPPGVEDGKLEGREGPGFRALVFDSWYDQYKGVVSLVSIADGAVKKGDRITSCHTGKRYEVLSLGVNSPEMIPTDVLRKGQVGWIIANMKDMSEAQIGDTFHLSSEKVEPLEGFAPTVPMVYAGIFPIETTDFLKLEEAIQRLALNDRSVTVQRESSMALGQGCRLGFLGLLHLDVFRQRLEDEYGHAILVTAPSVPYKVTWRDGREEIVSNPIHFPDDSERKGKVTLLEEPMVRGVVRCPEEYTGEIMQLCAEHRGEQLDVSFPPTASAIRSVQMTYRLPLSEIVTDFFDKLKSCSSGFASFEYSEDGYQASDLVKLIFLISNTVLDSLSIIMHRSKVLYNARAWTKKLKDIIPRQQFEVSIQATTGSKVIARETLSAYRKDVTAGLYGGHYERKLKHLNKQKEGKKRLKALGVGRVQIPTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQU7</accession>
    <name>W3VQU7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003997_0_0_1"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF10">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="827"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1101"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1308"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1367"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="681"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1568"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1576"/>
            <end position="1585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1595" mass="176024" checksum="CC06FD33A1C9CB9C" modified="2014-03-19" version="1">MSADFPLGFLYSLPPRPKTRSLGDHIAEHVTDNGRISTLIDCLPSTSNPALWSPDLSRPPLEHRHIKSFVSNFILPSRKPLGPNDRVMMALPTGPENALALLSVAAYHTCAPVNASCTAGELRDDAVRLRARAIVTTRDAVERLGLHTLRDQDNMEVIFVEPRTSGPAGLFDMSLLGENGVASTAGRRPSAPHNLEHQSLVLHTSGTSGKKKVVPYSLRHLIVGTCCVVYSWDLRPESVNMNMMPLFHVGGIVRNLWSPVFSAGSAIMCAGFDANAWWPLAKQLGATWYYAAPTMHHAILASKPEGVDAAKETSIKMIANAAGGLLPSLAEQLKETFAGCAVLPSYGMTECMPIASPPTNYQLDRPGCSGVACGPDLSIRDPFDKERELPVGQTGAVSVRGLPTFSGYEVSADPFEPLDTSSFSSEGWFDSGDMGHMDADGYLYITGRSKEIINKGGEVVSPFEVEEAITQACSDRVKQCLAFSIEHNVLQETIGIVIVPVPNQPRVGLAELHNMLRSHLHPSKWPFAAVYMDDLPKNQAGKPLRIKLGTRLGIGPLSDDVPPLQRHFEAKAPGKEVPLSEPIPCNLVSVDVRAVERACYRIPGIIEAAVRQRRDGAPEAFIQVEEDADYDAADIDRALAQVLHGYVVPNPLHVFRQPLAKNNGQIDFDTMEAEVRRQNASSMTRTALIVRDIIAKLLDTEAGSITAESDFFLLGGNSLLLGRLVHLIRKETGVSLEVSTLFNNSTVAGIADLVDDEQGDEDEEDDDFYDGFDDKGALGATYAAHRYDDDEDVAFSNHGYKPRSQTHPWVLFIQSIPFLFFYPLKAAWTWTVILHGLAFSAFYIRDIFWERVGALLASIIVARLTSRIICPITAIAFKWIVIGRYRPGKYPMWCNYHLRWWIVNQSLKTAGKGLFAMTPGLQKTYYRLLGMSIGSDVKIDQFAKIAEYDLITIHDGARIDKCLLRGFCVERDGYFRLEPIIVGRDCVINTFTQISPGARLADGTVWGPQSSSHEEPSSDAYAAYNRNNAPQPHWALMVLIGYPIIFFVRFACYVPWFASLFMLLSQPFAFDHHDSVKGVIAWFAYPRRIGWHYVARIVRNGMPPLINLAFGILVKRLLGLNREGSMRNATQYALFRRWMNQQLLSQPRVRRALAILGTHYEMTSVIFRAMGARVGKRVYWPGSSIYCPDPELLEIGDDVVFGSRSEVFTSDSIGWARVRVGRGAMIADRVVLLPGTIIGKQCVMGSGALARRNGHYEEGSVWMGAKHGEAVSFGKAVAEKSEGGLGSNGDDETITPFGRAFYRRQANFFVFPYLLLVVINVGMTIFSSAYWASAAVGTVLVLNMLRKHFEYSSAGFLFDDHWWRPGLIYAMIAVLFVVMLTIQAILAFAWTIATKWAVIGRRREGRYDWDKSSYCQRWQLHLTLQKLLGRGFGGHIYGNISGTAFAVWYLRALGAKIGKDCAIWAGGKPSLQLTEPELVSMGDRVSIDDCSVVAHINSRGRFSLNKLRIGDGCAMRSGSRLLSGASMEPRSMLLEHTLVASGEIAEAGAVYAGWPARQLRVRKAHRGNGVHGEMSAGSSTTNLHQQVPPPGYYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQX7</accession>
    <name>W3VQX7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQX7"/>
    <dbReference type="HOGENOM" id="CLU_1408986_0_0_1"/>
    <dbReference type="OrthoDB" id="2371309at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="190" mass="21852" checksum="BA8394293AAA5F79" modified="2014-03-19" version="1">MWCDNCLLLFPLRSGAMVWNVFIAAYNLAGSILLFQKGQFLFFNYPEYQIYGGIGMAVMAICILTTVGMANNSYMFMRLCFFVWPLILIVVAVRAGFMMFQLDRQQTKIVWECNNGGQLWGTQGENTGSTDTMPSGLCSAGFHSLYIAFVFSLLIDFGLQVYAYFMCWRFKKRIEHYYALATKENNIYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR41</accession>
    <name>W3VR41_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR41"/>
    <dbReference type="HOGENOM" id="CLU_013668_0_0_1"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="889" mass="96407" checksum="A4A76F3F1D238BE3" modified="2014-03-19" version="1">MAALGRGANINDLPTEILREIVGLVWLDSIPKSSFRNIDPHGLPSSYPDGRKISSTQNDTRKTLYNLCLVNKAFYHEARVLLFRRIQITLPHSFNLLLRTLGASHLASAYEKYASTGSVNVDPSDPASFVNMVAAAGFAHALGHKLVIGGTANPTPPASRTQSPAPAKTGATMERADSLTRGRSRRDLIRINADEDGEVELVWTEDATSTPESPVYHVTLREEGDEEAAELHRWVRLVDFSNFRTQGLRRTIGEGMERRFVTPARLLALVTAAEGLVAFGASETMDSALSNDVLEALLFRDGEYSKPSRLRGVSVERSSGRSNKMLQSLDLCECVSPRFEEAMKEFVSTHLKKFSGRMTDTVEEETESDDDDAAMDVDNEEEERGRGRSTRDRRQSKSLSRSVSTRRRDGDGPSRHPARPTAFPSLNRLGLSGVTLDNALLNPFVLAFPRLTHLDLSRTKTDAALLTALSSSHQLQLESLSLAFCKRITSESVTELLVDAPCTQGLVELSLAGTLIFPTPIDAEDLKVILTQAPCFRSGKLRYVDLGGCDLTDELLGLIGPQPSLLDLGLSHCPNIRLEAVSKLLRERAPNVQVLELSDSCTSRTSTEGLTTAIPGYDSHDATAINAVHLQSILVGPCAKTPPVPISVQLAMMGFKSGSELPQLPPAARAPTNLRVIGLNQASLKSVRGGFGSWRVIRGAGRRGWVVDVAAGPNPEASDEVLLENPPEAPVSEATVAMAREASAERGLRRGRSVRYDEGSLGRSDEGDRSSRSLLRVPPAPGSPSARPTIPSIRRAHSVGGGSGSRSRSRHILAASHALPSDVKLTPRDEVVRDLAPDHPRRVALQRLVDANGHVTGDIGWHSRKMEVLLGFGFLGRDTGLYALPSFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRM7</accession>
    <name>W3VRM7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRM7"/>
    <dbReference type="HOGENOM" id="CLU_1455006_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="186" mass="19382" checksum="B0AB31EAD65144FB" modified="2014-03-19" version="1">MHASQKKPALASCLLAQSSRGADLHTHSKANCKADCKVTLCMALEPFLEGPSPSPPSRSSSPSAKAQLVPAALSNQPQRIGITPIVHAQRRLEVAPSAVTSGPSDTPTRTIALQTQTRPGASHRKPLPSLVSIGPPGPEARTTSAHSARAINLPSELSDRLDASSERRVCQGAPGPVSDLRSIASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS20</accession>
    <name>W3VS20_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sterol 22-desaturase</fullName>
            <ecNumber evidence="6">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS20"/>
    <dbReference type="HOGENOM" id="CLU_023517_0_0_1"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="555" mass="62644" checksum="0C4098DCCE16AC4B" modified="2014-03-19" version="1">MASFLNAGQQDLNFSQSAPSAPLPRSDSVIGKLLSLVDLTRVPSFQEADRTTVVFSILAVVATLLLAEQYNYQKKKAWLPGPKWTIPIIGKFADSLNPSLEKYQQGWNSGPLSVASVFNIFIVIASSNEYARKILNSPTYAEPCLVASAKKVLCPDNWVFLSGKTHVDYRKGLNTLFTRKALGIYLGIQETIYKRYFDEWLADPTPEAQPYMMKFRDLNMETSLRVFCGNYVSDEGAKEISDNYWLITVALELVNFPFAFPGTKVYNAIKARKTAMKWFELTARESKKRMAEGGEVTCLTDAWIKAMLDARLQKENADLEAETRRVLVRDFSDREIGMVLLSFLFASQDAMSSGLTYLLQHVADRPEILRKVREEQYRIRGDDINAPLTYEAIEQMDYTKAVVKESLRMKPPVIMVPYLNHKEFPIDKNYTVPKGSMVIPSFWNSLHDANVYPQPDEFKPERWLDAEDPAQKNPKNYLVFGSGPHNCIGQQYANMHLTAVLGTASVLMNWQHEVTPLSEEVEVIATIFPKDGAKMKFERRAAPAPGTAPEVAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS25</accession>
    <name>W3VS25_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGT1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS25"/>
    <dbReference type="HOGENOM" id="CLU_006241_1_0_1"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="103086" checksum="D07C34850150F572" modified="2014-03-19" version="1">MEGSNAPPDGALPFSDVTGLLAAAASAEKQQAIVARIYVAPPAEPTSSSSSSIDQFAQLSLVAARLRQIIHEHSRSSPDLGIDQYIWHREPPAISIVNPPASSRASTSKQPAQPAHILFHLRTDGECMEDEWFATHLLLRASSELAEHALCISIEDEDGQFLLIEAADHLPDWVTPEGVVNRVWIHDGHLHLVAPHLAQISDEAIPIPRAIELVRDPSVLTTAPDDVEAAALARAYEYPSTASSHHHRTLAFLPRQVAQALEAEPQLIASCVAAIQSRDPLSSRSASRLVRFPPPTQPTSSSSTATASQQDQSSPNDIVLTRVRMTRHLYAQLLHDRFFPPRQLGPQWQAAVERFRMHVHSRSSAQSGPKIQDEQQVQAEIAHGRWHDLGAKIWCGLEMAFAESSTRRTRSGGRSIDPQVAISEAERQKLLASLERIGFFQGELQGSAKWKQLEAQALVQYVQTSTTNVNPEQTPLCETVDLILSTSSVPAIQSYPPEAALDELRRHEDDDAWLHLSPGEVESILAAKSGPNQEAPRAVDEDDAFQRLGAFNTKMAAFLETKSDVRGAVFEDEAEAMLDDDELLFEDEDEEEQERRIRVQVSQRLERDGEEEKRKMLERLLPRMSDTEWLRPTCSSTAKGNAGFVDSIDALSASRAPPPVAGEATVVVGNHLSAAEGELRRRLASQYMRDTSALLSSQGHEHIDGADESDGEIEEEVEPEVRRQRAQEYDLDPDVPDLPESDVQDGPEAWDEETEVANMLEFARISLGLSKEQYEEILSDRKQRGKFVPFQSSAAKTSAPQTPKPAKAAKAARVDEVEMQEQVQDVEMSKFEDVMAAMDRRLNSLKTTSASRTTPQTQEGASKPDDVDAELLSHLLTSEGDLPASLESLLGRGDAVEAEQLASFLRSFQAQSGAAATGPVQQLMQRFGLGSLPADQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSG0</accession>
    <name>W3VSG0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00906</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSG0"/>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000003">
        <property type="entry name" value="Elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="878" mass="97766" checksum="760E6428652E3D1C" modified="2014-03-19" version="1">MVNFTVDEIRGLMDRPTNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGDTRFMDTRDDEKERGITIKSTAISMYFPMDKDSLEAIAQKKDGNEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCIEGVCVQTETVLRQALTERIKPVVCLNKVDRALLELQVGKEDLYQSFMRTIESVNVVIATYNDPVLGESQVYPEKGTVAFASGLHGWAFTLRQFANRYAKKFGVDKDKMMVKLWGDNFFNPKTKKWTTKDTDADGKPLERAFNMFVLDPIFRVFDAIMNFKKDEIPKILEKLDVKLTQDEQDLEGKQLLKVAMRKFLPAGDALLEMIVIHLPSPVTAQRYRVETLYEGPLDDESAIGIRDCDPKGPLMLYVSKMVPTSDKGRFYAFGRIFSGTVKSGPKIRIQGPNYTPGKKDDLFVKSIQRTVLMMGRYVEPIEDCPAGNILGLVGVDQFLLKSGTLTSSETAHNLKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVQAWIAETGEHIVAGAGELHLEIVLKDLEEDHAQIPLKISDPVVGYRETVQAESSMVALSKSQNKHNRLYVKAQPIDEELSRLIEDGKMTPRDDFKARARVLADDYGWDVTDARKIWCFGPETTGPNLLVDVTKGVQYLNEIKDSCVAAFQWATKEGVTAEEPMRGTRFNILDVTLHTDAIHRGGGQLIPTCRRVCYAAALLAQPGIQEPVYLVEIQCPDSGLGGIYSCLNRRRGHVFSEEPRVGTPMVTVKAYLPVNESFGFNADLRQATSGQAFPQSVFDHWQLLPGTPLDAGKTQDIVLGIRKRKGLRESLPTLDTYYGMYPTLFLIVLTNKHTDIRLDLVSFSSFLHLFVLRQQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSJ3</accession>
    <name>W3VSJ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00952</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSJ3"/>
    <dbReference type="HOGENOM" id="CLU_012510_0_0_1"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="460"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="811" mass="87243" checksum="4A0FCFD3A8AFA68F" modified="2014-03-19" version="1">MAAPGTPMGASATQAATTSSTTDAPSDPLFSPPAASSSSSHQQHAASKLDAPARPPSGLSKRAHTPGQDQMPLTIHTAAQRGDLPAIMRLVDSGRATVHDRDDDNITPLHWAAINAQLATCRYLLDHGAEVDALGGDLVASPLQWAARNGHVYVLELLCSRGADPTITDSQGFNSLHLTVHSSAVMPLVLMLQQSSLSSPEGLDATDSQGHTALMWAAYQGDAISVDILLKHGSDVLKRDSAGLTAMHWAVVKGNRLCIRLLADAKSDLLAKEDSGKTPRDMAVELKSIGAYRKALADIGFEEDGRRKQRTFGASTDRTARLAVMVVPFIALGLIFATFAALPWYTAAPFAAAEFFGMHHVVTRVILDPQEHDFLQRSNYFLAIVSGSIAWVGWEWVRKLASNTPGYASTNLLFALSLLVCAWNLFRASTISPGYAPLAPSALHRRETVTQLAQQGRLNGQTFCVACMARKPMRSKHCKLCGRCVARHDHHCPWVANCIGIENHRQFLLFVGALVLGILQFVYLTGVYYAINAPPYDPLPDASIETCHLPFAALCTATTYDPFLLGVAVWAALQLSWTVILLGAQSWQVMRQMTTLEVSNLGRFGFMGGKGGQSYAGQTNFIAMHSRSQPGASNGAATTLQGIQAQQKPTEADEELPSSSSAGHSHSHGKLGVVRRVAAGAGGWLLSVVGLDLYTRGKAGEGLKRANAALNPFDHGMLANCKDFWSKGADLAIDYPTLYDLPAEISPGHCDTLPFITDSLSAGSARWRNSAYAPLRTSIDEADDEDRPGTWSMWSSIRSQRPLLPTAHTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSM9</accession>
    <name>W3VSM9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006564_0_0_1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1165"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1240"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1409" mass="151713" checksum="D3571B5A58F6A2D2" modified="2014-03-19" version="1">MQGSADIPGNVVVKQKSRPYRNNFRLHQPSASAVAVIGCVAFDCNPSRHSTPVFDTSRRPSQGSLHTALFSVALQPSIRIRPSLHRLPGAAHRFIRLLQPRILHCDSRTSSSSALILALARTDAAPLADPPGRSTLRLPPPLLNTCHHLRSTSHAYPGPSIALDYAMAASDSHANGESSRTTTDVTAAASVPSSKPSKRKAEKMQTSPSAADLADSNGVKPLARAVLVCKRCRSKKIKCDQAFPACGSCVKAGEPCVGIDSATGREVSRSYIVDLEHQITQLRAQNAELERLLAERPSSGPLEPGALGMKRPLQHVEDEFPLAASEKSTSPDARPLKRLAASPESDRKPDPARPFLPGLVLGPAGVEVVPSDADGHTTSGARPSMGRLNSHASGLSPARLLCQAIQQSAQAGLHVRDPGSAARIRRSGTQRLGDELNRRATTLSSQDPSKLLSESREAQDGGAKAEARLGSPQSGSATPSDTKKNSPFDDGDPMQYATATETADITVPAPEQALKPSPLPAPFPPLSIARKLIDAYFERVNPQLPILDRSSFMTRFEKACKLGLERARAKLSAHERGTQEDDDDKLAIELQPADGHLFHLVFAIAAAMGWTRSSWSAENHHEAAMRFLDPRRLATPNQEGNVGAIMGRDALEQLQCLLLTALYSIMRPMKPGVWYCLGVALRLTTGIGLYTETPGVLEASASASQVVGETLAERKRRLFWCSYALDRQVCVHLGRPFGIADSDIKVNLPWVDSAGDMIQVAIEHQGSDVRQAGSAENDGDSSIEMARREAASTLAALQSSTSEQHDSNRQVAPVSLPKPKDASRWVSLSFFRMRILQSEIQSILYQNAELPRRFSSYGHWKNDVLQRLHAWRRYAPSSKAELEANGCGYNPIFLELNYQQTLLMVYGLSPRFPNASRKDLASVEECSRSIINMYATLSKEGQMNYTWMTGHNVFIACTSYLYAIWQISATDPASFRSSVTLGFRNKVDEIHHFAAACDKVLSSLQWATAEKCRKCLRTMFYATSVVVEKIDRAAPAAADGGSRKKTSHDRPADRSTQRSKSGANVIKKPHFASPGRESSSLHASASPQRYPQGTSPGPWSLYAQDRDWRQPPSDGASESGPAQPHPEASAHPSRWNQRPGAVRSPQQQSTAPWPAAELGHDRLATSHDPYASSSGTTPSRGLDTGGGATDASSMSHAWYEAGPGTSPRVMFPDSPSNFDISSLMATSAMELDALFREAGLSAGPSGDQRGWETSTPAMQHSALGPAPPLHGAAGGREQSAPHYVQGEALSFYESVGGSVEGADASKWGFPAGSGPGINVEHRMAEDMGQGEAFESDWEALGFGYRIAAPTAYNAFAEPVSDAQQRGFTSMRGDVQSTGAATAASAGNPATGNLATTEFDHRFLDSHMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSS0</accession>
    <name>W3VSS0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSS0"/>
    <dbReference type="HOGENOM" id="CLU_1107791_0_0_1"/>
    <dbReference type="OrthoDB" id="2552817at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="250" mass="25193" checksum="7AC396171575869A" modified="2014-03-19" version="1">MSQIPGTNKTTSDVSKDAQNVANDASKQAQQLGNDASNKASDLASQAQQQGDSLLKQATDLASNTIAYVQQTAGDILGAGKANAQDAADQTKSAADDAAKEASKTTDQAAKQGEQSAEEAKQTLIGLTNQARDLASHTLDSANQYIKPAEQNAQGLVNQARTTAANLVDNVSHLIAAGQNKAGEVADDASKKAGEAQASASQFANDAADAASKKAGEAQKAGENAGQQASQALSDAAAQAKGAVQGVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSZ8</accession>
    <name>W3VSZ8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gpi anchored protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSZ8"/>
    <dbReference type="HOGENOM" id="CLU_038125_1_0_1"/>
    <dbReference type="OrthoDB" id="526316at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834846" evidence="3">
        <location>
            <begin position="19"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="89"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="411" mass="44920" checksum="FB2A8EFD61CBA0C8" modified="2014-03-19" version="1">MIPALMLGLTLVATAAYGAVLPRSGTFQHPGLLHTDADFTRIKSKLATNSQPWVRGYETLVNNTNSQLGYVASPVENLCRGSNAGCTENYSNAFRDFAAAYQHALRWKISDDVAYAEEAVEIVNAWSSTMKTINGASPDRYLAAGIYGYQLANVVELLRAYSGFSGQNLTAAIRLLNEAFLPNNVDFLTQHSTYGPDDVHFWANWDLCNYGSALAIGIVSDNQTTYDFAMDYFHNGKGRGSIGNYLWKTYDDYTAQGQEAGRDQGHAMLDLALIGPFATAAFNQGDDVWAYNDSVILKGAEYAAKYNLGNDVSYTPYLAIDSSGKVVYNQTTISNVSRGDIRPIWEMFYNEYVVKRKLPGTYTKLYADKVRAANGGAEGGGGDYGPNSGNYDQLGFGTLMFTLDGSDAETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT70</accession>
    <name>W3VT70_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Liprin-beta-1/2 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000390_0_0_1"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058914">
        <property type="entry name" value="LIPB1/2_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26022">
        <property type="entry name" value="CC_Liprin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Liprin-beta-1/2 coiled-coil" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1375"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1598"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1661"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1931"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2000"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2059"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2260"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2446"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2513"/>
            <end position="2535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2569"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2668"/>
            <end position="2759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2995"/>
            <end position="3076"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2813"/>
            <end position="2994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="857"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1289"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1392"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1496"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1527"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1576"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1682"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1763"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1938"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2009"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2033"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2059"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2072"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2084"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2121"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2271"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2600"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2671"/>
            <end position="2736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2737"/>
            <end position="2746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2747"/>
            <end position="2759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2995"/>
            <end position="3010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3054"/>
            <end position="3067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="3177" mass="345329" checksum="B1CF47F52E5928F2" modified="2014-03-19" version="1">MVLRCYSRRHVVPAFRAARRQLTTGLPLSAAHTNIPSDQSKATSAGALSQSRRVGRAGHQHESWSFFFPDHLSWTKRPSAPRASHPLVKKLISEIYSTDREPSANRAWKAYTDLKEASGAHAVGQSSESFTALLTQLEPAHLQQLLRAIDPAVATSRKLARAEGKHFQSLQQKQQVLTSGLAPTKILVEPQTSRKSAKTFDAQHPVREYMRRVHIIFRDMRLHSSVVPTTSSATDSLPSLDDYNHVLARLATGGHIGPMSAIWNELSGVTLKSGTKGLHPNRHTYRELMIGLSRHATEQIERVQKNEASKTFDYSGKKRQLEKSARAAAAGMAKFGQILAPSARAAAILAALRTMALLKDMKDHGVTPNQITLDFAARTLRLAGHTDGLHMLMHDAYGIDLASADTADTSSTELAPTTHTLNTILMALGEQASVPEMVAAFETLAKPLPVASTGTDATSSGEGLFSTKWKDIFSSMRNRESEADQPGNVQDEADIPDVFPYTFPHRIQPNTKTFQILLRHCCAEVDPLRSPVALKNEAGGSVAALAMESTQLALAEMQDGGPRAAEMERRTKGAYSLFARSLLSEAVGRSEELLHSTARSLGIDLQQRDVLAEAAAKEVESSGDRDVAEATQLRPEYQRVSVIPGRAMDTDFHPIYEAPSFSVTALMVEPFFSLASARRNIGDLRWVRGMLSKALEIKIAETQVIDAAWRVYRSRFSKTRQNTSAAPASAGEHASAESDSSASLQSNGQGRAEVSAFLQRLRQQHRIAAKHAQSLEQLLYDRLDERLHDLSARRDAKQQQRQRAFRERRLEAEQQKLEEQEREAARKAQAAKARRLRALQKEQQQNPSADGSSTHLDAASSATASRTTDSIRASSPVALNGFAPTCRFNVPSATSAPDWFSKQVPPQSSNTAVKMADAEAAERAAKAARARAKLKKHQAQKKAAAEAEAEAAQTTSDKDADNADSPAPTASNGAAAEEESAESAVSPEEKAGSSSHQNAELKNAQSEVKSLTKQLESTRKELQTATDASSSLQHQLKETEEKSKTSVQAAEESSTVQIKKLEHDLQAQQAKAADLEKDLQQQRDGLKKAEEKAKQSGERIAALEASLKDGATSETSLKNRIGKVEADHKQAQDRASKLENDLGESRKALDKATGDAKDAAVKLKETEAKMATETKAAQKLEEDRSKLQREVEEQKKQADQLRSSVETKDKAIQDLQSKLDDPSKSNQIAALSQQLQESNAKISSLESGLAEKDKSLKSSASDSDRLSKQLADLEKKAKAAESNASTLEGKLKESTDREAKAKASLQEAEAKSTKFSAERAELEKKHGEAEADAKSWKEKAEKHSAALAKAEQDAANVQDKADAKDKELTTLQAQKQKLDDELSETKSKIESLTKQQAALEAAKAEAIGNSKELDKSHASQISELDSKIKQLEDQAKKDSVAATKLLDDAKKRGDESSKYAEDLDASLKESQAKVKALEGQLQERDGKLAKAEDQHASTQKELGSASTQLESLKKELKSAQDQISSIQKERADSLKKVEDLNKQLAKLQEDHKEVSSSRSQGQEELEKSRKQVASFEVKEKEWSAKHKELEELKSKALQEAASLRSDVATHKSGSETTSKELASVKEQHAKSEADLKAAKQEVAKVTAAQTEAEKRIKELDAQLTSTKSEADKTREALQSVKSELDAEAKAHSAADGTAKERRADLDKAAKHAEELEARAKSLAADLDKAKADHKQAQQETAERQKSLDAAKREAATTGDELKSVTTKFNESQAAYKKLEADKAELDRTATGLRKQLGNAEKKAESSSAALVKATKVHGEALAQKDKELAQAQEQVEAQSKQLITLEDKNSSLQKTCDQLRDQKDKLHMELEASKAEAETHKSAADGKAKEIETLAAKVSTTEANLAKSTNEAATAKKRIDELQKEVQATTKDLEAARKASAANKSSAEQSQAQVKTLEAKIKDADAELVKARDEISAARTQVTQLKDELVSKAKALETAMADAAASRASAEEQGKEIKTLQGKLKDSEAKLTKATQEATSSQAKVKELQIELQAKAKELETKSSEADKHHSQAQSLSKQLEASKQQHTELSSKLKDQVSANEELTKAHKQTSADHATAQSELEKQRALLQKSSEDHEQARSEAKQLSEKLQQAQADHDGVKQTWSELTERHNVLVATHDEHKKAAEAQAKKIEAATAKIADLETKLSESSAARDEVRAELADKVGRFQELESKLQAAEAEIKTLSERAISGDEALKNKQQELDALTSQTKQDAETLKRLEKELASAQKSAKDGTLKHKAAVTSAAKQLEAIKAELEKAKAEHAEAMQKAAEEHESAAAEAAGQIDAVKAELEKAKAEHADAFAKISSERDGALSAAEKRVEDIKAELAKASEDHAAAFKAATDDHNVAARGAAEQIKALQAQLEKAKAGQAESTKAADEQLAALKSELAEAKSQHNASMATASREHESAAAASGKQLKELQAELEKAKVEHAQSAKTANEQLEVLKAELAEATSQHAASFKKATEEQKSAAAANSKQLNALQAELEKAKAGHADSAKAAKQQLDSLKAELADAKSQHAASLAEASDEHKAAAEASTKQIEGLRTELEQAKAKHSESAAKLAQEHRAASDALGAERSKLSGELQKLREVHAKALSTHTTELSDMQEKLSVAADEHKQAKDAHSNEIKALKASLEKGKKERDEQMAAHTREMLDLSKAFEDTRAEIQRKETELEEHSQQLKSVRSTLGRTEEDLKKRHEHAETLQKQLEEVGRDLAARNARVEKLQTDHATSLEAKTEEIASVRAAHDDQLASERSRLEASLADVRTELAGAKSELAEATEKLASMEQDKSASSNEVGKLSAEVATLKKKHLTAKSSAEAAKKENAELRTQLAGIQKQVEELRSGSDKVRADGELQTEALRSELELARVRAQEAEAEAARVREELETKRDAVQVDNTSVFSKEHVDDVVQAHELELSALRSQIRKLEASMFEETDKAHRATRKAIELEERLRSTPGADASTPAGKTNGAGRSHKRSATTTHVPSLSPLAEREVDFAEPTPSASSPTAPTRRGIRTITASELPLPAAQRHRRRESLQMLAARIGDAPATSPTTESALPQVRSVTLESKGHTPSNSIAHATPLALGADADESLRSAQRVRPQFANDELLYCACCRDDLIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT97</accession>
    <name>W3VT97_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT97"/>
    <dbReference type="HOGENOM" id="CLU_076407_0_0_1"/>
    <dbReference type="OrthoDB" id="5418203at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039884">
        <property type="entry name" value="R3HC1/R3HCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678:SF0">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678">
        <property type="entry name" value="GROWTH INHIBITION AND DIFFERENTIATION RELATED PROTEIN 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="307" mass="31455" checksum="4F6C5E9184EC988D" modified="2014-03-19" version="1">MSVASALPLLSPLVTRILELSGFPPHLKTRDLQHAFAIYEDDKGGYKIKWVDDTTALIIFADPATAKKAYLRTIMAPPHQLINDTGVPAKIKPYDGDDASAIISSVSNRQRSRSNVGGVMGSPTKQPAELPMPATPDHSKPLRGHAHTPSFGRSLGHRRQQSGSNPNLPPKPVAAALFDAANGGPSPANRVLAGVDTLSGIAGLPANPVAAARSTLVADSPTKMSRTSSNGAASTGSDALESELASLSLASTASASRTATPDGLMAAAPIGNAASKRFSPASAPSALRQSPLPRGQTGAAPQSTTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTB5</accession>
    <name>W3VTB5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTB5"/>
    <dbReference type="HOGENOM" id="CLU_036234_0_0_1"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="78"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="389" mass="42413" checksum="8F4634564A74EFBB" modified="2014-03-19" version="1">MVKSKKGGSSEAARDHASIALASGFLAVPVSIAQAKTSKKADEVTHWVYVRKHVSSGASSSVASTSKLTEAAQLPAERTLFMANLPVDTTESHLRDIFAKAGNISSIRFRRSASADEEDEHEEKGQGEDSTDDEEEHHQLAQAKGKRNKGVQKKSRVPRVEALPSLDPREAMGSQALLTTSSSAHIVFLEPSSLVRALELLQSGIRWTDPFRSLRRQAEKHTDIPAARATTSASFLLSAGAGIPPVGLELLLSQYSACRPELSDVQAWADSRVALYQYRRAHPLPRKIGVRGVTVGPTGELLDEDGFIIVQRSGKYGRAGAAADAGGSVGVAKHDFKPNTKTKAEGLEDFYRFQMRERKRQQLADLRAKFEADKQKVASLKAGRRFKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTE0</accession>
    <name>W3VTE0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTE0"/>
    <dbReference type="HOGENOM" id="CLU_017594_4_2_1"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="505" mass="55665" checksum="98CC37E29149C6BB" modified="2014-03-19" version="1">MEPTAESSTLHSSTHADNTDAPEATATTPLLPRAAASHERKSWSRYTRLGLSLTGVLILGVLVLTLLGLHSAADDGATSLWPNATLSNGTHTFRRTVILISLDGAKPVYLDSGHAPHIQSLSTQPNGRRAEYMQPVFPTLTFPNHWALLTGLYASSHGIVANDFTLGTTHAQFYYTDPRRSWPGSWWLGEPIWATVQRAGLSAAVLMWPGPPVTAAGVKPRYFQKYASGPEWDLQGRKRAVLDWIDMANVQDRPSLICAYVPDIDQAAHRFGPNSTQALQAVRAVDAFVGELHTELVHARNLGGVVDVVVVSDHGMTSTSNARLVFLDQVLDAKVLAAVQTRDAWPLAGLRFRGSQAEQDRMAQLAYTQLKKDAKGYDVFWRQELPERWHLNSPTVRDRLAPLWMVPWPGWSITDHAEFATFANGTYAPRGNHGYDNTHPDMHAIFAATGPSFSPHPKQGKPVMEAFDNVQVHNLVARILGVPQRTRAPTNGTWSFWTPHLRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTK0</accession>
    <name>W3VTK0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTK0"/>
    <dbReference type="HOGENOM" id="CLU_009066_1_1_1"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="160"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="699"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="778"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="797" mass="84704" checksum="638B369D0257A44A" modified="2014-03-19" version="1">MSSEHPVAATGAEASPWAPTSEPVAGAQSAQIEADSTEAVGQDDHNTEQTGASEISQQVKEPPTSPSTTLQATTAEPTEVNAPPAAVEEGAKDVEQPAASDEVPLSPASPSRIPPSMSIPEIKAALASERDQAKAAAAAASGGTASTAESSASTGDNVILGIAVVDFNHLVGPQIEYTYPKQLQEDEDLVRSLPFLALPDGSHLSDEDFCYFHLHCPKLSDSTIFGISCNRQIAADALLRKGAEVTRSTVQKAIVVLAKEPIFGPIREKLGIVTRAFFAQGDLADVDILIDFHSTLEIGLQSGGMSEDRETVMYMGTSLRELVHKWRFKTLMLVKLLLLQRRIMLFGYPVEQLCNYQYSLVSLIPGLLLSLQDAGDPKLHTRSSRVEAADSLRSSDRKSLLKFLGMPLDIFGEDAFFQPYCPLQQIDLLKSRTWLVGTSNSIFKQQRDCKIDVIVDLENAHLDFQDPKLHQAVNLTPEDRKWMDEVISSVVDTWNPADPTRPTSMGFHGSDDYLRIRFEDYICAMLSSTKYADFLAKSDAEQVAIQAPDASTTSSFGAEFLAALRGTEAFALWSSVTDSMLFDIVDHKHPCEGKTSAIEDVGLRLSAGLHDLRLEENLAPTREAIGSALQAGSANIYRLATNFRQDIAKFRANHAAASQNSGGEGAGTGTGGLGAITSGFGFFASGDKAASSGQVASTSTGAARASGSITGEAIDADGQHTTRSGRTAPVEGQGAGAGFNANEALNAAGQAAAQAGTQVRVALGNFGSFLSARQKSWAASRANSSTPSSANNSHPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTZ6</accession>
    <name>W3VTZ6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dna binding protein ncp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTZ6"/>
    <dbReference type="HOGENOM" id="CLU_694784_0_0_1"/>
    <dbReference type="OrthoDB" id="3364747at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="384" mass="38222" checksum="DAC35009845C9323" modified="2014-03-19" version="1">MTDLSRNGSVLVAEIKAIHPPQGANGAAAVPGTATDGGAAPAVDPSITSPQASQISNGHAPQASELSAGTGAIAVNHSADPSVATGVAVPATVPESAPIAPAAAQPDHAAAAAAGAGAGAAAAPGLVQPQTTPIQPYQPSEAALQPTHINTAVPAAGAAAPASAAPSALSAAGTAPGTAPGSVISATSPISAGQAPVQPQTAPVAAQQPQQLNAVAPAAAGAAAGAAGAGAIVAHPAPTTVAATEAPKSALSPKEVKKMDKLMKTEAKNEHKSLKRAIKDAASAEKLFRKSRDAEQQSIKRHQKATTNEHKAAKALNKAQAEHEKYAAELAKAVEELDIKKRHTESTREGYEKAKKHIDELRNQKTVNDQARSRQAAQIHGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUE4</accession>
    <name>W3VUE4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUE4"/>
    <dbReference type="HOGENOM" id="CLU_154783_0_0_1"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF19">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="102" mass="11565" checksum="9019C0FFA0D95CD7" modified="2014-03-19" version="1">MPVVHIVLVKVKSAVLSNGFDELKQKCETLKDLPIAASKATEIKWGPPAYPGRNEGYNWGLYSVFATREDYEAYRDDDEHRNFSKTVLLPNVDGILAYDFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUE5</accession>
    <name>W3VUE5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mfs multidrug</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUE5"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="113"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="549" mass="59947" checksum="DC86799704C62196" modified="2014-03-19" version="1">MSIYSACRFAPCPFLTTSPPSYESDPTALGLVQDTSMSSSPSVQSATASLRSDHSLEARADHANHMEKQAESPAAAATKQEEDVNHKAFLVDWDGTDDPENPLNWSTARKHGITLTLSFAVVVVTFASSVYSSASSAVAKQFGVPGKVGKLGITLFLCGYAIGPLAWGPLSERQGRKPPMLISYLGFVLFSLATATAKDLQMLICRFFGGVFGCGPLSIAGGAMADYSSLEQRGIAIAIYSFATFAGPTFGPILGSFIVESHLSWRWTEYLTAIVGFAFLLVLLVALPETYAKRILQKRAERRRLETRQWAWHAQLDEEAFDARVVVTKFLTRPIVMLVIEPMILLLSIYVAFIYGILYLLFGSLPVHYVEVRGWSEGVGSLPFLALLIGCGLGCLVMVGFNPRYVHMCKLNNCQPVPEERLLPMIVGAVVFPVGCMWYAWTTYASVHWIVPTLALVPIGCGIILLFLQALNYLIDAYLAYANSALAANSLLRSLFGAGFPLFGTQMMVNLGLQWANTVIGLIGVALLPIPILFYIYGKRLRRSSKFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUG8</accession>
    <name>W3VUG8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUG8"/>
    <dbReference type="HOGENOM" id="CLU_020336_20_1_1"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="82"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="352" mass="38653" checksum="3516B8EA6EAFE06F" modified="2014-03-19" version="1">MASEALLPIGAAFNGATQHDLDRAKAEAGEAYFPTVFNPATVERKGHLVIGKGRAGVAKGSQDGFKVYYEVHGKGAIKVAFVMGLNNTSFGWLPQVDHLARDERYSCLVFDNRGVGNSETPAGWYKTSDMAVDTFEVLEQVGWTGERNVHVAGVSMGGMIALEMARQRPELLASLTLISTAPGKRFHTPTYGLTSLARVLAGRTLGFDSEQYRLNRLISTLFPESWLAEKSEKDASRTNREVLYDMFKWRYAFTIRQQLHGAVSQMKAAVTHYIPDADLARIDTAVPKISILTGDTDFLVDPRNSAYLRDKLPSADFHEFPNAGHALGNQIADQVNAILEKAFADAIAAQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUJ2</accession>
    <name>W3VUJ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate lyase</fullName>
            <ecNumber evidence="5">4.1.3.1</ecNumber>
            <ecNumber evidence="4">4.1.3.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Methylisocitrate lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Threo-D(S)-isocitrate glyoxylate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00923</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.1" evidence="5"/>
    <dbReference type="EC" id="4.1.3.30" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUJ2"/>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="693" mass="76224" checksum="7BF4A499AA6F742D" modified="2014-03-19" version="1">MLDSSTGRSSSRALPAAHSTTKTATSTQQLLSSPLVLKHLVDEEHKGAVVLAKSDVPLVERGWPDSQPRKYASAWSATFQHSLAAQQLAKLRGGAASGPDSPPAASRASTYTPFPLLVLVLIPSSHLHHTSNQKALAQQLQRTSSRIHPYPNLKVAQRSSAIMADQELKQFQEEVEAVKQWWKNPRFANTTRPYTAEQVVSKRGTLKQTYPSNTQAQKLWKTLEGHASKGTTSHTYGALDPVQVTQMAKHLETVYVSGWQCSSTASSTNEPGPDLADYPYNTVPLKVEHLFMAQLFHDRKQREERTNMSPEQRAKTPVVDYLRPIVADADTGHGGLTAVMKLTKLFVEKGAAGIHIEDQAPGTKKCGHMAGKVLVPIQEHINRLVAIRLQYDIMGVENLVVARTDSEAATLITTNVDERDHAFILGTTNTSLEPLVDILNRAEAEGADGPKLIALEDEWLAKAQPVRYGDAVAAELEKKGKKAEAEQFRKEVLGTSLIKAKAKAKSLGVEIGFDWDACRTREGYYRYQGGTDCAINRAIAFGPYADLLWMETKSPILAQAKEFAEGVKAARPHQWLAYNLSPSFNWDAAKLSTEQMKSYVWDLGKLGFVWQFITLGGLHSNAYISDLFAAGFAKEGMKAYVELVQRKEREIGCDVLTHQKWSGANFVDSCLNTVLKAASTSAMGKGVTETQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV67</accession>
    <name>W3VV67_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV67"/>
    <dbReference type="HOGENOM" id="CLU_600089_0_0_1"/>
    <dbReference type="OrthoDB" id="3366916at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="456" mass="49054" checksum="25E08FAC658207FB" modified="2014-03-19" version="1">MDGSTFMAGSTSSGCGGTKPALPQRSRRRSMVGEARPTRFDAPPLPGMVASSSMPQLDKRSSTSHVVSVVAPLRIADKKRSSTISITASASCTPTMPQKSRFRSSVDSHTKSPPGPSGAADDSTESSPSSIATSLADGELGRAYTHDAVFTHNVAKHARKRSSLAAVPMGISRSHQEMIDDSPGTFHRTEAAGLFDSVRGLMHDLQLDIGRDDAKSKPEAGQDLRSWLASPQRTEPCSAPAINVTTDTPESSPQAIPPKADGSAAGGSEGTSPRPGGLWGFLRTPSPLPMRTSTASSYSSTSSFIASDPTASSTLSLFSNLLGRSTPETSSPEEAPVRLARTRVDEEKLAHLMISCADTRHVLKTECDPAKLRDTGLRLEKAWRDQLQEAGALRTKLAVAQDTVEDLEDENRQLRKQIAQLAEIIVEREEQLRNAEQQRNEPVERNKQLEQQYQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVN5</accession>
    <name>W3VVN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVN5"/>
    <dbReference type="HOGENOM" id="CLU_016678_3_1_1"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="88179" checksum="BF8FA721B697C4B4" modified="2014-03-19" version="1">MAPTVTAPRQAGTDAGPDATAVAPGSPQSSAGASADMAQPIPERWDGLDTTILGDLARRGLMSTLDTIKEAKTLMLDPSLAGPLGLVADVSGLKQHGVEKMFWLEPASAAFVSKTDTAHSQALSKAGLKSVNAPTKSVVYICRPEIKWMKAIAEQGDLPDKDAPNEVPSSNNTALLYASTGAEFEDLERQQLTLSPRRHDYVPKEHLRADRSVRPTSPLQHTYTISFVPHRTEPCLQFLDQEGVLSDVSLLDFGLEFVPLDHDLISLEDDAAWKKIYCDGDHTPIFRSAQALMTLQHAYGLFPRVLGKGALARRLADLLIRQRREHLASDPSNPALTTPSQLVDSLIIIDRSLVDSLIIIDRSVDYATPLCTQLTYEGLVDEVVGISNGHVEVDPALLTGQAQPPGGGMGAQPHASGSGTPLQMTSTPKKRKHRLDASTDVLFGEIRDLNFAVVGDRLHRAAKRLNHDYEGRHQAKTVSQIRAFVGKLGGLQSEHASLRLHTGLTEKIMEWTAREEFNRMLEVQQNSVAGLELGAQYAAIEDMINEERDLLGVLRLLCLTSVVGHGSSAGGIKPKNLEFVKREILQTYGYQYLPLLLALQKVGLLTRAAPGAADAGGGVAAGFGALTSVVGGGSSAAGGAAAGDGKDEGGRGGFASVRRSLRLINDDVDERAPSDISYVYSGYAPLSVRLVQAVAQKEALLDAGRAASTALRPGGRSVKPRAHPIVGWRGFEDVVGQLPGPTFDEVQSGAAGLGGSDTSTTGAAATMPSDPDQVTTTLVFFLGGVTHTELAALRFMNGQTRNRRFVVATTNTINGNELIRSLSSVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVU2</accession>
    <name>W3VVU2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVU2"/>
    <dbReference type="HOGENOM" id="CLU_2347604_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="97" mass="10127" checksum="1DAA792060692212" modified="2014-03-19" version="1">MLLKPLFAISTCSSSSVDATTTIICHPSIAHFGVSDIDVDTSARVHSHSALVHPWPALLRFFSSATARTSSRKSVGTTGLPYIALHRPAAAPAASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWY3</accession>
    <name>W3VWY3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWY3"/>
    <dbReference type="HOGENOM" id="CLU_2723265_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="72" mass="7633" checksum="F58E8924372EFC55" modified="2014-03-19" version="1">MSNLSICGIVRFRTRWALNPFSVPAPPSMDGRASSASSLPGPQASSLNTATNNLDDPIRASETMVRPQLGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD47</accession>
    <name>W3VD47_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD47"/>
    <dbReference type="HOGENOM" id="CLU_041939_2_1_1"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="65717" checksum="048B370CA6463CAC" modified="2014-03-19" version="1">MTKEESGAVTEQNRLLSRLLSLRCTSAGDAGEPSRSAQAQGDLLVRVSDQVPAGRGLVYTTAVEPGQVLLTLPADLLLNVKSYADFFHPETLPAAVSVAGPSVTIDSRLSSAQLLSLLVARAQLESVSQQLGQDQKHATPKHQALRLFVQTLPVEFGTVPLVWSIQARNIDQKVSDGGSKEASWKRRFFRSLLEALPRHSQALERNVRRRFEKDWARLCQLRDSKPDLLAEPALLSSHSELARQIVRSIDVDLFLWAWLCVNSRCVFLPLGLADHADNFTLAPVLDMANHTPDPALECKVRYANNGGLELCAPSQHQQFQFQSSSSAATMMPGDECCITYGPHSNEKLLSEYGFVLSPRLHYRDDAAEAPSQSEGRWCGSRFVDVLMDQEVEALLAAQGSSGQDKIELLQNRGYWGEFTIHPYPEPAHPSHRLIPALRLAALDMHPPASHPSQSHKVAKVKSHPGVKAGKKASYPPHFGINDSSDLDRWEETLTGYRENVSEENERRAHVLLVELCQIRRAHTDEARRHLAEAQSILDGASKAESRVASTTAAPCIEPDMQGCVLSLAFVKQLLDEEESVLRRVSQAARDQVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDI0</accession>
    <name>W3VDI0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDI0"/>
    <dbReference type="HOGENOM" id="CLU_122437_2_0_1"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11586" checksum="627B8DC6148D0F40" modified="2014-03-19" version="1">MTAAGKLLLTIGTLVFFHAAYSTYEHLSLRKALGLVGAEANTMPLDITLETLVSFVVILLGIAFTAAPLKNVTWASEMRTKTIDEVDSRSSFATLTHRGQVLFDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE59</accession>
    <name>W3VE59_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PaG_05896</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE59"/>
    <dbReference type="HOGENOM" id="CLU_047751_1_0_1"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833087" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="37"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="44"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETS59923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="327" mass="34875" checksum="23A89663BC7DB281" modified="2014-03-19" version="1">MSTPSSPPRRLCENRKVALLAASLLVLVQNAAVVSAAKQTLSPFDCSNVAVSSKHAFDLSKISYPIRTANTESTPPSETKTSIDIDLCKPLAADPDRDEKDQCPRGTRICITIETIKDGKTIVTQAIPVAYSGESGGSKIDAKVEWGEELEGGEKSVELQLQGSTYAGRQQQAELELVCDPKADADSHPTARSYDRADGKLKLRWPTKFACSDAASKPGSGGGGSSDDGSNDGSSSNGSESSGGWGFFSWLFFLLFVGFVGYMGMGMYNNYNQYGASGWDLVPHKDFWRESPYIARDAASHVWQTVSGSRNGGGFSGPGGRGAYEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEC8</accession>
    <name>W3VEC8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucosamine 6-phosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEC8"/>
    <dbReference type="HOGENOM" id="CLU_048635_0_0_1"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="63"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="293" mass="33132" checksum="577BBD2B7FB43969" modified="2014-03-19" version="1">MIRSASAVRGARASTSNLIVRADGDGWPPAWLLPSIKQFSTASVLWSSKGAERYAFPSKANPTPYEIFHFPKRGVTSAEVKSRYYDLVRTLHPDRYNSDQGKTKSQVEEEFKQVVQAYNILKDSKKKHLYDRAGLGWTQTSPSIPPWQDRRYTRRYSPGYRGEGHDRFGWQNHDFYSNFTRPSASAAGWNGGNGKITNGYFISAIFVLTWVLAGLQYSRLSLQSQKAIERADKHHLDAAKSLHEARQIARSDEGKQRWFAIRQRAREQKFLQDKDSQDDAGAYGVGHGGPSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEU7</accession>
    <name>W3VEU7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_06049</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEU7"/>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_1"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="13">
        <location>
            <begin position="377"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="13">
        <location>
            <begin position="549"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="699" mass="77200" checksum="48BFA768B5F267DD" modified="2014-03-19" version="1">MCGIFAYINHLVEKDRKQVIDILVTGLARLEYRGYDSAGIAIDGDTEKDTLVFKQVGKVAALRKHIDESHIDLHKVSISQMGMAHTRWATHGQPSPINCHPHRSDPTNEFTVVHNGIITNFRELRMVLEKRGFRFESDTDTEAVAILCKYLYDSAQGRKPDFTSLIKSVLKELEGAFSFVFKSVHFPGEVVIARRGSPLLIGVKTEKKLKVDFVDVELGGAVEESGFGDAGLLAPPGGDPSGPGSLSVPNANNKLLRSQSRAFLSEDGLPQPIEYFIASDASAVVEHTKRVLYLEDDDVAHIAEGELHIHRLRRNDGLSSMRSIETLEMELAEIMKGSFDHFMQKEIYEQPESVVNTMRGRVDFDKRQVKLGGLTAFLNTIRRCRRIVMTACGTSYHSCLATRAIFEELTEIPVSVELASDFLDRKTPIFRDDVCVFVSQSGETADTILALRYCLERGALCLGVVNTVGSTMSRETHCGIHINAGPEIGVASTKAYTSQYIALIMMAVQLCEDRTSMTERRNAIIDGLHALPAQIKSILAQDKALQALAHNTLAKERSLLIMGRGYQHATCLEGALKIKEVCYMHSEGILAGELKHGPLALIDESMPVILIMTKDSLYPKVQTALMQVTARKGQPIIICNDDDQDIKEGMKTIRVPRTVDCLQGLLTVVPLQLLSYHLATAAGVDVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEX8</accession>
    <name>W3VEX8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEX8"/>
    <dbReference type="HOGENOM" id="CLU_024997_0_0_1"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004566">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="264"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="656"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="694" mass="75108" checksum="A4D59C507D46415E" modified="2014-03-19" version="1">MPAYTDSICVFCGSSPGTKPEYMAAAASVGHAIAKRNYRLVYGGGSRGCMSGVSQAVFEAGGHVLGVIPQVMATTVPSGHPGQKLNTVVSKEGTGPTVLNPDAGTGHVETVVVQSMHERKQRMAAESNLGFIGLPGGYGTFEEVMEMVTWTQLGIHRKPMVLLNVNGFYSPLKQQIQLAVEDGFISAAGAELVSFVDCDASNVDAAGEAVLSEAVRLASNLASNGSGYWDWNKPQGPVSTAEGGIIDNAASKSIALAEGETLAVQVSDLTFSFYPHLPPSLERCNLHLKRGSRCLLIGANGAGKSTLLRLLAGKKLCDSKVRVFGKDVFRESPSGVTYLGTEWAMNPVVRSDIVVSTFLDSVGGYRHKERRDRLLDILDVDLTWHMHAISDGERRRVQLCMGLMEPWDLLLLDEVTVDLDVQVRADLLDFLQLETEERGATIIYATHIFDGLQSFPTHLAHMRLGTTTTTLPIDWPATNPADVAALPPTASADKDRDLSPLLNVSLAWLREDKVVRADEEAKRGRKRGANRQNETTDSEKFFSKYDYIGCQSLLSSPTMRILFSLLVVGVVVGMEIEPVIEGVDVVWSGVGHPPRVANVDPVAFPRAQGFFDLWTALPPRDEPLPVSAYPRVGQNEAVARDRSSLREMIEQSPWVGKSMQEVGESSAQGASRQVGRLSKQGTRSKKKGCLGCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF01</accession>
    <name>W3VF01_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF01"/>
    <dbReference type="HOGENOM" id="CLU_056040_0_0_1"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="335" mass="38068" checksum="E5021EF3D37C305B" modified="2014-03-19" version="1">MWSPLASASIVFLILYLFLFAFLVALFALRKVPWKSRWLVLLLHVLCRLASQACGLAFGIVGYSNIDVLVAYYVLGAEGYFTLVVCLSRYLIAWQRQHWRGYSWMEPVDPYAPKHGKAKLRFKQLFEWKESKDEPKSAHALLVVDWLLIAANVIIIVGGSLSAAAYTNSDLTYTQREDKLKTSRGMRAAGQAVFLVINVLLLVCIVVSMQQHRQHRFDNGAPNRQENEPAQDQKPLPGQSVDQSERRPWYGHKTLALIYLTWPFLAVRGIFGVAQAVVPDLNYFNSEVYDANNLTQQFVTEETCMVTMMEFISATLIALTYFTTRSEHHTARAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFC3</accession>
    <name>W3VFC3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFC3"/>
    <dbReference type="HOGENOM" id="CLU_034027_5_0_1"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="394" mass="40991" checksum="3884A5564A5BC776" modified="2014-03-19" version="1">MMDDLTEASSDYVPNSWVTWFLATKGNEYFCEVDEDYILDRFNLTGLNAEVQHYPQALDLITDSLEDDLSDSIRDSVEAQAKLLYGLVHARYIITTRGLGKMLEKYKRADFGRCPRVLCWQQPLLPVGLSDNPFQKAVKLFCPRCEDIYSPKSSRHGTIDGAFFGSTFPHMLFMVYPTVIPSKSPTAPSPFLLSASQQHRADARAQAEHADVDDSIMSVPGGAGNGSSLPAGAVPSSSAAAAAAGSAAAGGASTNATPANSTAAAAAKVERYRPRIFGFPVHETSKLQKWQDKVRDQQIERLEKVEAAGGIATPGAAAFFRKVAPAPAAPAAAGTAEAAEAGAAVTPAQAAGSNAGAGATSTSIPPPAPASATTSAAAPAPAPAAAATAPKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFL3</accession>
    <name>W3VFL3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_05537</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFL3"/>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000016">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="105"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="321"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS60339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="429" mass="48062" checksum="927C7582987BFCB1" modified="2014-03-19" version="1">MSIVRPRGSVPPAKIKVANPVVELDGDEMTRIIWQKIREDLILPFLDIDLKYYDLGIEHRDATDDQVTVDAAEAIKKYRVGVKCATITPDEARVKEFGLKKMWLSPNGTIRNILGGTVFRAPIVLDDLPRPVPGWTKPIIIGRHAFGDQYRCQNFAVDKPGKFTMQFTPEDGSAPQTWDIFNFPDAGGVGLAMYNTTESITGFAHACFKMALEKKMPLYLSTKNTILKAYDGRFKDIFENLYETTYKKDFEANGTWFEARLIDDLVAQAIKSDGGFVWACKNYDGDVQSDIVAQGYGSLGMMTSELITPDGQIIESEAAHGTVTRHYREHQKGNETSTNSVASIYAWTRGLAFRGKLDKNDELVYFANALEEACLDAINAGKMTKDLALIYHGKQMKREHYVTTMEYIDEVAKILKHKLSAKGIEAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFQ8</accession>
    <name>W3VFQ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFQ8"/>
    <dbReference type="HOGENOM" id="CLU_023205_0_3_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="301" mass="33276" checksum="E899AB6949D18E8A" modified="2014-03-19" version="1">MPIPTVRLPSGVELPRLAFGTGTALYQSAAAKQVTMALNAGFRFVDGAEVYANEESAGEGIQAFLKSSGLKREDIYVLTKVGKDGMKDLQSAVKEEMRKLQVDYLDSYLLHFPPRGKDGLPSNVDAWRQLEKIKAAGLTKSIGVSNWLASDIQQLLDAGLSVPDINQIEFHPYLYANAEYTKLLALQKKHGIVTMTYAALAPFYKSTLPEDGPLHKALTAIAAKNDQRTTAAVLLRWALQRSEGIITTTTSKESRANELLDQLDSNNDAQLHLDEDELKQIDQAGKEHGYEKYYMAPFMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFS1</accession>
    <name>W3VFS1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GABA permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFS1"/>
    <dbReference type="HOGENOM" id="CLU_004495_5_0_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="58953" checksum="AFD2BB2AEEEB5EA2" modified="2014-03-19" version="1">MADIKQTTSVHSVVSAGAGADARLASMGYDAELKRNLSMMTILGLSFSIIAAPFGLSTAFSIALTCGGPITILYGWLLVSIISLCMAASLAELCSMYPTSGGVYVWAAFVATKKWAPLTSWIVGWVSLVANWTLCLSINFGGAQLIMAAVSQFRNNEWAPQAWHTILTFWACMLIAAIVNAYGVKYRYLDRLNTLSFYWTAAGTIIIAITVLTRAKDGRKDAKFVFSGWENTSGWPDGWAFFVGLLQAAYTLTGYGTVAALCEEVSEPEKQVPKAMVYSVLAASITGFFYLIPILFILTPDAADLLSTAAGQPIPVLFSLATGSAGGGFGLLFIILGVFTFAGIGSLTVALRCTWAFARDGAIPGSKYWSKVNKTLDLPLNALILSTIVVSLLGLIYLGNTAAFSAFTGVATICLSISYGVPIAVAMFRRRAMLKDAPWTLGKFGYVINAITFVWIVLATVLFCMPTTATVEASTMNYASVVFAFFFVLSAAWWFAWGSRHYVGPLGAAPEDAAAHIRPQHAHSTALPGDSKPAVEVASHSSEEKDAAHNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFS4</accession>
    <name>W3VFS4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFS4"/>
    <dbReference type="HOGENOM" id="CLU_513053_0_0_1"/>
    <dbReference type="OrthoDB" id="2576334at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="552" mass="59789" checksum="A805A325CE500051" modified="2014-03-19" version="1">MTSQWDPDYWGLTSSAPSATLNPQAAASRTAKPSYATAYASYDNDSLPVTPDVVANPWNTSLLWSAGIVDNRDPRSNFWPIANWRNFSIPSNIDTAPIQYYYSSSNEGDSVNFVFTGHGLSVLDYRGPSRGEYNLTIDNTTTVVINAYSANDELASATGSQLPPVIWTSDTLDEGTHSVVMSNMNNQTHMHFWGIVINPNNYVPGKSFLHIASNVKTIIIASTVTASVMLLLFAIAASLFYYCKLVRPRRRLQSQMDAERKDLSLLPHSISSSSTANSSSRSQLRLDTAFLSSQGDLGRVPSRVTATTNESQYWLQPDIHHSLTADTSTRPSNRVHALFQEVTPISPTLSSPSSPTANTPATELDSSATAYSTSFGCEPVSPISPSNAYATAQSPTQHRNFWDASHQYSVAARPNHARGASTSDLDPFQDAHSVSLSPTSLTRSASRRPLPTPPTAMTPVSPVTLPLPPAVPPRPNQTIGAAHIPTSPATSSLGPAVPPRPTASAERESSRYRVEQDACSIHFSDNGLFDNHTGETLLPPPYAPRDMGRHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFW1</accession>
    <name>W3VFW1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFW1"/>
    <dbReference type="HOGENOM" id="CLU_039848_7_0_1"/>
    <dbReference type="OrthoDB" id="4250781at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000104">
        <property type="entry name" value="Aerobactin siderophore biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="2">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="427" mass="48247" checksum="C630E24C806B1BEE" modified="2014-03-19" version="1">MTKPQTISASPAVRQPGLRATFCPRKEERVFLARGAHLFTLPGRQVRVRVQVDVDAESDEESINASETTITISIAQAEQDAFNAVARWVKLDRLAKTSLHGVVNEDRATFQHAWAFELLNETSDPLRVIWAAIYAFWIRHKWSDRLPVLFQGQVAAQQQLHLVAVGLCFASPTDADLVLLDRNAFWQGAGAPSDLHWLQTPVPSNGLFPYVSAFTQSASPPVLAMHPLRPPKPAPGSVVYSRYVFSCSQHLELVHIDRSNSQHFEAYCRWQNSDRVNHGWREKGPEEKHSKYIEEKNADPHAMGVLVLWDGVPAGYGEMVWSKEDGMAAFVGGLGNYDQGTHLLIGEEKFRGKHRFTACMVSLKHACFLRDPRTEVVVGEPRYDLDIIPLLATFLPQEIRKEVELPHKRAVFFVLRRDRFLEEGILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG15</accession>
    <name>W3VG15_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG15"/>
    <dbReference type="HOGENOM" id="CLU_016023_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="888" mass="99017" checksum="9BBDED50DBC0E7BA" modified="2014-03-19" version="1">MKARCPPSAKAAAASWTHTFAHPPTPTRVVTAGTSRLHAFSTITTRSSTASMSGRVSMQMDSPQLATRPDEALVTSLERPRQRPPWVRLNLEDTVRIFAPGASTFPFTEANTLEDTLVGLAAYSPGKYAALASNHERMRLILKAFLRRSSLSEADWVAIRNAMLCKSWSDARRYMVNTDDSAWPLYVLRRAVSKVATPSEASDALALLALTVQRVASFSTDLRWESYSYLTTSFATISSFCFSGDGRAWHLVPRLGDVLSTMISAFPNEMPKHRSFVFDFTRRCTRLADERARNAMICVLESLQGDGQPTKRIADVRNEVIQIVVGRIEIALTKSAGKTAASEQFANTELMDLLTEQHVPQHSPLEMRALLSAVAVAGRNRDYRRIRHYFDRLEQCKQELDIRVAATDYLELAKALVRTAQGSHDAMEALQQAERLLAAEYEDADMEALPEPAKRRLNHVCLDMLQVMAKTPEVHLQEALSLLGIFVRGSGADMEGERGETHPLMSQAFKQLRGDVYAYTMMMQGCLLRGRPDVACAVWQAMLDRNVLPNTACLSVLLQNLFRHQEVAEALRQLALWTDVGITQHAARPQTMQDIELESLGAPAFVLPFSQPHASLSETDEVTDRYKVEADPILASVVFSGLHSCGAAGTESLWDAYRQTVRLFPDAPVLALFLKAACGTEATSSQGASFGRQVFRSMLFGKHPELANFRAPLQEQLEAQGAAGWILSHDAVGAKMEQWFSSAFGVKQSSTAVSPDDLGALVFTSKLFEHYLRLLLAMQHLPGHVSDARLVRQELIDVLAWMRQLQLKPSETHVALSVLEIEERLPPPIAARHMEVLDAWLADWLGEAKLPSEELMRRVWRWKMERNGQARGWFDRIPGPWDEAPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG22</accession>
    <name>W3VG22_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_06629</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG22"/>
    <dbReference type="HOGENOM" id="CLU_001493_7_0_1"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="187"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="901"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1152"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS59696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1209" mass="133707" checksum="F50FF438764330CB" modified="2014-03-19" version="1">MQGKSTGGRPWNGGGGGTVPRSSSKKRIRHSDLDLVVKQSGARATGQQRASRSTAASTAAELQLRSKTNRSILAMSALPFAAARGGPSLVGRRLLSSRAPAALARLPRSFHDPTGPIKLASVSSSSVAAAVRALHASSASLKKQERRKDADAKEFSHTLQLPSTPFGIRANAAQRDHLFYDRTCGELYAWQRARHDSTGDFVFHDGPPYANGHLHCGHALNKILKDITNRYQVLRRKRVHFMPGWDCHGLPIEAKALANVSPQERPKWTPKDIRTRARREAMKAIETQKQEFRTFGIMADWSNTSTYRTLDPAYEARQLRVFGEMVRKGLIYRQYRPVYWSPSNRTALAESELEYRDDHTSKAVYVAFDLIAGPTLLEKLGPHAHHARQLKPIIWTTTPWSLPSNMAINVNPDLEYSIVRRTDSQGPCYLIASDRIEALESLTVDHSPDRDGDPQLFGPVEEVARFRGADLADSTYRSPLSSSPTAARPILMADYVTALSGTGLVHSAPAHGAEDYQIWKQQGRLQTDGIFSPVNDQGCYSSEILQLDASQSSDSRSDTSIGRRLMGKEVLSDGAREVISILKERDALVCAHTLRHKYPYDWRSKQPVIVRATAQWFANLDRIKQQAIDALRDVVFVPANSRARLETFITGRSEWCISRQRVWGVPIPVLYDLATDEPLMTVENIEHIASVLESKGTDYWWEADAQEFVAPQYRDEKQSWRKGEDTVDVWFDSGTSWATLKDQLALESPETGSSGPSSIADVYLEGSDQHRGWFQSSLITAVATTPEGQTPIAPYKTVVTHGYVLDNESRKMSKSLGNVISPLTIIKGGKGASQPAYGIDVLRLWVARSDYTTDPPIGDTIIAKTAETLRKLRNTARFMLANLPSGQAIIPLERSQMRLLDRFVMHELYLLERACAAAYEAYDFAQVVRRLTEFANAILSNLYLDVGKDCLYLDAMDDPRRQTMVSVIDAILRTMTGIMAPITPFLSEEIHHFRNGASSDPMEDSKEAPSVFAAGWPTLDAQWSDTTTAGHCHELLKLRDASLVMIEEARQSAGIKTSFEVEIDLIVTEDQSQVSTILQAHESELTELFNVARVNLLRQGCAAEADPEAVLVSRTLDSGSSWTVPSCSPGPVFEGLECMKEPSPLAQICAEHDGRAKHPRDSPQAGGLLASDLARLLDQRRPPASASDDLVSLHGPEAELIASMGEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG80</accession>
    <name>W3VG80_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_06324</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG80"/>
    <dbReference type="HOGENOM" id="CLU_026673_14_0_1"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="204"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS59797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="376" mass="40162" checksum="EEC3136C5998F825" modified="2014-03-19" version="1">MTKGETIKCKAAVAWEAGKPMSIEQIEVQPPRKGEVRVQITHTGLCHTDAYTLSGSDPEGAFPAILGHEGAGIVESVGEGVDHVKEGDSVILLYTAECRECKFCKSGKTNLCQAVRATQGQGVMPDGTKRFSCNGKELFHFMGCSTFSQYTVVSQYSLVAIDPKAPREKTCLLGCGVTTGWGAATHTANVEKGSNVAVFGVGCVGLAVITGAVDAGAGRIIAIDTNDQKEEWAKKFGATEFVNPSKLDKDVVAHLVDITDGGLDYTFDCTGNVKVMRSALEACHKGWGVSTVIGVAAAGQEIATRPFQLVTGRRWQGSAFGGVKGRTELPGIVDRYLKGTFKVDDYITHKTDLDNINKGFEYMKQGECIRCVADMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGB4</accession>
    <name>W3VGB4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_0_2_1"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="516"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="877"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1309"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="890"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1256"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1281"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1336"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1574" mass="170164" checksum="AC7FFE76F0B24634" modified="2014-03-19" version="1">MPLTRPDAPTNAQSDLTDTMPMQAPRDSASGAAPSQGDGESDQAPPTAPNTDVNAKQKQDPSIGPTNSAATQKVEPTDSKPLPQDEPPPDYEDIPEIDSSPSGSAEAAAAEGPVRDTHPPPKEVRAPNSAKVTNTIPDPAVSLSTSRPTMLPPPRPSMAASSFINPTPTLTPGSTWGPSAASAAAARAEAAEPGRIGDLKRFTLWETKTRFYLVAYNTSQTRFRILKVDRTPPTAPVSTRSTSEAEKPRESGSTSGTPATPAVSAQIDPAPQNAPSSSNAKTAEIRLETSKPTKANAAASDCSVRGQPYVSLNDPQICKLNRRMLDAMQTPRDGTNSTSANAALKSDAAFGKTSSAAALPNTGNAASLIPETKAGGGASTPGSRHIESSTDSKTTGPRFKSTAAADWELNVTSDRVVYSRTQVAELLEMIREGNRATGGLQEVGRFFGIVGFIRFTSTYYMVLISRRSVVALIGGHYIYHCDETVILPVCHPAVLASLPGRTKLMEQEEARLLHLFKQVDLSKNFYFSYTYDLTKTLQDNLTSTPGDPLEQASSVSPSKQPITAWGYNEKFIWNHHLLLPAFGASEHLQPDEDPRNEWVLPLVYGFVDQAKLSVLNRTVYTTLIARRSRHFAGARFLKRGVNERGHVANDVETEQIVSEALTTPFFAPGRKRFEPRESKPRASTVTRRGGDLIRARGLREKASTQDASQIDSQIRREKSRAVEHHWDNGVDHGDEEDFEDLPLDPSPRYTSYVMMRGSIPVYWTQDSTNMSPRPPIEISLVDPYYSAAALHFDELFHRYGTPVIVLNLIKSKEKQEREVKLLRTFGECISYLNQFLPTSKKIRYIAWDMSRASKSHGQDVIGVLEDIAEETLETTHFFHSGPEPSAFRAQPSSHAMTQSHDSTSPAEPSHESSNAGSKSTARGHQPRRETILLQEGVARVNCVDCLDRTNAAQFVIGKAAFGHQLHALGLLDDPSLPFDSDAVNMLTEMYHDLGDTIAMQYGGSALAHTTDTYRKINQWTSHSRDVLESMKRYYANSFADADKQAAINLFLGVDPAAPDFSPHVFPENFPVSTKKTTENGHEQSTKVVRAVPFRPHYQHWFDPLHLQPRGTLESRERRLRQVANADAGFWAEYYRPSLFTDLNRHHAFKMTAVHQYSHLHGGVSHASGGLGMPHSQSAGALSMYAGQIGGAAHLTRHVRSASNSSLSSGTFNPHHAGYMVEYPSPFKPRGGAADLSAYRTSQQQHFRRGESDARSLGTQSSATMVNEAQSPVSPESGQHFLSSPAGSASSALPPSKAIIGGVRRWISINKPGGSPRLGGTGSHKSRHRYSIASSEGGDHQHEDVRRGGDSAGPVRGASVPSTGAVLGGFDPHTFNFAGRWQTVNPVGPAVAGSNVAIEAALNKACNPHISEEEESEYAFYTTQFLDEYARPSSGDAASDAEQAGRVDGQMPLERTAALTDHHLIDEKDIQIYEEGVAVSGGKAAAVDRFVRYSTIDPVLVSHAHAASQLAFPVAVSAVQSGMATAAQGSQFSTGAGAAAVAQAAAVPSGLTASEAKIRAYTSWLSLGQTKLVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGB5</accession>
    <name>W3VGB5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_06279</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGB5"/>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001455">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="79"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS59756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="510" mass="55410" checksum="1241417E20B23396" modified="2014-03-19" version="1">MSSANAPTSAAPGAGPVTMDGSASGALREARIATHSHIKGLGLSDDGTALPSAQGFVGQKMAREACGLVLDLIRMKKFAGKALLLAGGPGTGKTALALAVSQELGQKVPFCPMVGSEVYSSEVKKTEVLMENFRRAIGLRVRETKEVYEGEITELTPTEAENPLSGYGKTIAHVVIALKTVKGTKQLRLDPSIYESIMKERISVGDVIYIEANTGAVKRVGRSDAYATEFDLEAEEYVPLPKGEVHKRKEVVQDVTLHDLDMANAKPQGGQDIMSVVGQLVKGRRTEVTDKLRSEINRVVDKYIEQGIAELVPGVLFIDEVHMLDMECFTYLNRALESTISPHVHMLDMECFTYLNRALESTISPHVILATNRGQCMVRGTEYEGPASGTGIVAPHGIPLDLLDRCMIVRTMPYEKDEIREVLRLRTKVEGHLIAEDALEKLTEEGVRSSLRFALQLLSPSSILAKTAGRSEITTKDIAEANELFMDARRSAKVLTATSETAEAVPMETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGF0</accession>
    <name>W3VGF0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGF0"/>
    <dbReference type="HOGENOM" id="CLU_066075_0_0_1"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="240" mass="26559" checksum="A24BE7EE93D18997" modified="2014-03-19" version="1">MTAGSDSKLLLYTAKVCPYAARAELALELAGLDYDVFEVDLMNKPSWYADKINAASKVPVLVSTRDNVEFKLPESLVIVEYIHDLSGRIFASEDAQHRAVSRYIVQRYEQLVQPHYYAAAINSQSESVGALLEGLKQFSALLGTFDPATRGGAYIQGGTRFAYADLGVAPFVARILSVSREGLLPKTDAPAVHEAFASDPALARLNEWWSAVQTEPAWNKVWDETKYLAPFKRRLASLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGM8</accession>
    <name>W3VGM8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGM8"/>
    <dbReference type="HOGENOM" id="CLU_014218_4_0_1"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000138">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="401"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="641"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="832" mass="89426" checksum="B698B0F59F738505" modified="2014-03-19" version="1">MMLRPQTTAVRPTIARVAAARTASQHCRHQIHHAAATTSSHTDPTPRSLHTSGPATSRCGSRRSARYAGMQYSTFHSSCRSPSNAESTAGSLHAPASDMPSVSPRSLVKYLDTYVVGQTKAKKVLAVGVWNHYLRVASNQRMREEHEQRLADAQPDDATPASRSLRLGKYQRDDSPPDGDEAIGESWKAHHAIQQERAAERTRDPHGEATRSLMFGRAEREWLVNAGGPQAIDETRGKPERKFGDTAPARRAVQTPAEEAGQRLSQGGSETALAEAASRMHEAVLSDYTPAAKRTLPPAEVGEEEAPLYFSSNSIAHRSPNTKPVPRARTSKPEADVHKWESPSDRAAHAASLAEERTRRALRAAHQRLSTPTSSAASATPPPTGLGSFMSSQPGTLPFFEKSNILLLGPSGSGKTLLLRTLAQALDVPFVHVDATPLTMAGYVGDDVETIIQRLLVESGWDVERAQRGIVCIDEIDKLRRGTGGGGAGGKDVGGEGVQQALLRMLEGTTIQVADKSGAAAAGGGKAKPQQAWSPLNPGEGGKELGAWYNSRRQRVGGRDPAGGVQGQGASVSVDTSSILFVLSGAFVGIEETIRKRLASHGATLGTAELLARLEPGDLEQYGLIPEFIGRVPVSVVLAPLTHDDLVRVMTEPRNSLVDQYTSLFQLNGITLHMTRGAIEEVVHRALGTSAPSLASSASATSNKDKAEAKVEAKVERVAGGGARSLRRIMEEILLDAFYESYGSSSVKYILVDRAAVRDGHVKLFSRGQKFDFDAQCGLDSEAPSATRPPPRKDRHQVVDPTRAAVARLKARAMVRARLRRTNRLVDPVIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH61</accession>
    <name>W3VH61_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mog1p/PsbP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH61"/>
    <dbReference type="HOGENOM" id="CLU_081345_1_2_1"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19759" checksum="4C19543BDF8AA018" modified="2014-03-19" version="1">MSSASEQRDLFGGAITVSLPKGFIDASDFRQVPDNQEVLVRDDSDVSLIIEVLQLATDEGAGESLDRAVRFHFDSLAHDNSASSSSIQATQIPTEQQAQPPATPPPALLTGTQIVRKFGKSTEPEEQVTIRVALWRLASKNIDLVLSVNEPAGASSSPPNQSGLAQSAFEAAAASLQIRDWDLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHW2</accession>
    <name>W3VHW2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHW2"/>
    <dbReference type="HOGENOM" id="CLU_034114_2_0_1"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="147"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="408" mass="44465" checksum="96E40588ADF4855D" modified="2014-03-19" version="1">MATAAAATMASTSADALPPFIVQASTSRPSKPNTQSQRRLKGSNTAARLVHYSGEVHPASSSSRISKYAPTFTKDDMDVDQDDMDAGNDQDDDVKIAVAGTSIASSHVFMKGHGTFLSTNSEEILSSMCGTVERVNKLISVRPARSRYAAEVGDLVIGRITEVGPKRWKVDINAKTDSALQLSSINLPGGIQRRKVESDELQMRNFFQENDLLVAEVQMMFQDNSSALHTRSLRYGKLKNGVLVTASPNLIQRLKSHFVHLRNDDLSLDVDLIIGLNGYIWIAKHFPYNQPSNSSSGGAASAGANSEQQKGLAGSGVGMDIDATYSDQNDPDLSPELRRQIQRVAKCIHILDAYHHPISDTSILALVSISVAYVGPILQQHEQQDWHRDPNLTILMVEQLRAGATLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI09</accession>
    <name>W3VI09_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI09"/>
    <dbReference type="HOGENOM" id="CLU_013637_0_0_1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000259">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="618"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1057" mass="114167" checksum="BF4172399A4EC2FB" modified="2014-03-19" version="1">MQLAFTFGKEPFAEWGIQCRASQLAGAHRTIRKNGTNGARLEARRTLGTGVDRVSKARRACRLSIPPVSPSIRPVHNPTRVFANAPFLLTLRSAIPQRRLACPPPPARQRAELLSRSTGYRRATGLRNPPGRASQHPVEHQDSFSRPSAHAMSRSPPAMSQHAPADDVELDKQRPASHASSVELPISLSFTSVASNAIHAPTEPPTYNAYNAEESFLPYLDDDVQAAQSAGVARASASSRLTPRPLDSPQLAHLSPTPHTQPRSSTPPSDSPRDSPVIDRGAIRSDSPYNSPDLAFAIPAAVEQQRNERQSLVAPATATDRTSNRYSKVLHGLGLFGAVSKRKSRADMSAPSNPKGLRIETSIAIDDVDSASQSSSGLRPPISRSAGTSPLASPALTYKAPTAHHLIGGLAVNHAQGLSSSSSFASHEESKYPTSHNDQFSTGLVPVLNIDDAASSIYSANTPRRPYTPGSFTNGPRTPLSATASPTMGYFDEKKIAGSMGGSSVSLSLSPAGKADSVQEIKMWGDYDAETEPDDYLHEPDADADKSSSKHIFSPRGMLNIGTLALLGVALLALFGGYPVIAWLSRPKASTKGGFNLGGINATGQVADLHIGRALVDPDTPDNVRTRTTLDGTGRKMNLVFSDEFNRDGRSFYPGDDPFWTAMDLHYWGTDNYEWYDPSAVTTANGSLVITLDQIPTHNLNFRGGMLQSWNQFCFTGGYIEVSMVLPGAPDVAGLWPAAWTMGNLGRAGYGASTDGMWPYTYDACDVGTLPNQTYANHTGPIAAQTTGVYVEKYGPYLSYLPGQRLSRCTCNDSDDHPGPRHADGSWVGRSAPEIDIIEASASHIRGSRGYASMSAQIAPFSSGYNLSDAPGSTEFFSQDASLNTYTGSVYQQAASGLVYTKRGAYQETLGEFSSYGYEYNPGSDPDSYILWTVDGNPMWKLNSKALGPDPATEISQRPIPYEPMYILLNLGISASFTTIDWNRLNWPATMLVDYVRVWQVEGEENVGCDPENAPTAAYIEKHKEAYYNANLTTWTETRERGGYNQKFPGNSMLGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI28</accession>
    <name>W3VI28_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI28"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="12"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="524" mass="56838" checksum="05480EF475F22E2E" modified="2014-03-19" version="1">MALPPKLYTWLCGCFAALGSILFGYDLGVIAGVIVAPDFLRVTKNPNSDYIGFIVSSMLLGAFVGCIPASLIADAFSRRFAIMVGAIVFILGGVLQTAAANQGMMMAGRFFAGVGIGMLSLLAPLYQSEIAHPSIRGRLTTLQQFFLGIGALIASFVVYGCSLHQAGTVFQWRFPLGLQIAPAVPLAFLIMLFPESPRWLMSKGREEDALRSLARLHARGDTSDVFVRAELAEIKAQLAIEKGTSSGWSEIFNSSQNIRKVAIGVILQFSVQITGVAAIQYYAPTIFGAFGYSDSKVFLIQSINSIVALVGEGACVLFVDRLGRRWPLITCNAIAGACFAVATALQARYPAGSPDFTTGAGYAFIAMIFIFNFAFSAGIGPLSWAVPVEMFGTSIRAKGTALTSISCWVANFMIGQVTPKALESVGWKYYILFAVGGFTNALTFWLILPETKGRTLEEMDRFIESTPWIVAFHDMKVVSSKEREDELRRGVVHAPQAEFLETGSQEEKFDGLKTSSHDHDLEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI32</accession>
    <name>W3VI32_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_05302</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI32"/>
    <dbReference type="HOGENOM" id="CLU_525921_0_0_1"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="466"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="518" mass="55446" checksum="C1971A8A64F5EC79" modified="2014-03-19" version="1">MHPPPISIHPTSTILLHVFDEPSIARHLHPHASPTMSAKDYYGGQGGGYPQQGYGQPQQGYGQPQQGYYPPPPQQAYGGQPQQGYYPQPQPQPVYVQQPQKKGGGGGPGACCACCAGAWTVSHPQLPRLEAQALRRPTLDTTSTSTIAAVLFSSPTSPRNLPSTAQQTRSTRRASNFPLRRSTPQPAAAAAIMNSILSRFDQPTTSAFAGANDAFGGDVAAQDQLMGAPGQFDLPNMDPATFLSQYTDVDSSNPAAKIKLAHGTTTLAFRFQGGIIVCVDSRATAGSYIASGTVKKVIEINPYLLGTMAGGAADCQYWETYLGIQCRLHELRNKERISVAAASKYLSNLVYGYKGMGLSMGTMICGWDKTGPALFYVDSDGTRLKGDVFSVGSGSTFAYGVLDQGYKWDLTDDEAQELGRRSIYAAAHRDAYSGNTVNLYHVRENGWEFIDNYDVSKLHYDGPGDNVPGAPGGGYGWEVRTKGLSSKLEAQPGQSQGGQGGRFADEQPLAAQVRPEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI42</accession>
    <name>W3VI42_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI42"/>
    <dbReference type="HOGENOM" id="CLU_051899_0_0_1"/>
    <dbReference type="OrthoDB" id="2549635at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="405" mass="45014" checksum="4B7ED043E78B4F4B" modified="2014-03-19" version="1">MFVPRKLQKRTHPGRAQTRTDEHYQDACAPQTHDTPAAHSVDVDAGKLERLVGFLHAVLNPLHVALSARDEARTLPTSTAWSDLAAAIAARGSGIHLARLLQLVPGLATRCKSISLLAEALTTCKTRAAAGWYGLDAFRVTWSDGYAEIVRDLVAADGIAEVLGSRLVYIEHIPPTVRTRPQATEYVARLLKDGADAGVFGVLEPAVVQHALMANKTAELGGRWVSGRGFFVLDARSVEYLCDAYPWDLAQRVHKGEPLRCLSWSQWERLHAMYAHQLAQQSAAPSVKVEDKWWRGTMLLLRLPVREGCLSVPESGDRTVGFWNRHLKPQLERHVPESIAYMHTHHDAVAIRTAHPACATQLLAHFPQLHRMPPSDEDDQWCQLPAKIHNAAHTRLLALDHNHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIE4</accession>
    <name>W3VIE4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIE4"/>
    <dbReference type="HOGENOM" id="CLU_016459_0_0_1"/>
    <dbReference type="OrthoDB" id="10261257at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="64832" checksum="6705D36D8BC98AD3" modified="2014-03-19" version="1">MDSSSALKMGEKDPSAPARYMAHPSTMRSQDIRRQDLAAIQRNEVSSIDVPATLPPQHTQASGLVGPCLQQATSPSVETHQPNDSGAGPAVLEQRPLIAVLPASEPWEQPSINTLPSPTANARASRLFRERRKERERVLRQTVAELADRNAALEALLFHHGIVPPGLRQDLSIHRSQRRGGPPMHIPGVTTSLPTGLQSLPTTQQSGKASSASGSGSRDHDFSSGSSRDSSDCFRRTAPDLRTAQQTPCEPMLQASGMVMPRPTAQMFPDGLVHSHGVYYRNAGIGQHQQRANHLATRDSSDLANLAALNPLPAPSTTSTASDATAAGAATTAAAEAESAVALATQRQRRQAAGDAFNAPTRRPMGRAHLRARSPSDSTLSDRRLPSTSPERMPTGTAGLFPYQLSSGYGRQGMAISAPGAGAAIPSAGSNHLMVPETWLPHTCAEVAGHSSRALPSEPARAITQSLTQLAEPIAVQNGLGSPAAPSTARQSESLPGRLPVWTVGNSDWPSASAVHGSASASSSAFGSTRGVPYPWLRQQGSFAQALALMPLSDSSQGSGSSASQASTRESHRSAGDSVPEEAGPDRRWTSVRMISDDASTPPARLGQPGSTLSSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIM1</accession>
    <name>W3VIM1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="8">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="8">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MEF1</name>
        <name evidence="11" type="ORF">PaG_04553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIM1"/>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_1"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="101"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="258"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="850" mass="92996" checksum="EE691DF8492CD9F6" modified="2014-03-19" version="1">MVAIPRVAAARSLARQLARHNIRVSGISATPLRIAVAAVPTASSSRAPSSFRNFSISTRRSAAAAAAVKAPPAQDAAAQSAHDGSHQPTSELTETDLSRLVRQRNVGISAHIDSGKTTLTERVLFYTGRIKDIHEVRGRDAVGAKMDHMELEREKGITIQSAATYCSWKATPPTEKSSVSGDAADIESKDLMAKKEDFHINIIDTPGHVDFTIEVERALRVLDGAVLVLCAVSGVQSQTITVDRQMRRYSVPRISFINKMDRAGSNPWRVIGQIRNKLKMPAAAVQVPIGAEDDFIGLIDLIRWKAVYNEGHKGIEIRETDEIPAGYLELAKEKRAELIEQLAEVDDEMTEIFIEEREPTIEELAAAIRRTTTRCQFSPVFLGSAIKNKGVQAMLDGVCAYLPNPAEVPATAMDMSASATKKAAEEAAKAAGEDEEAAAEARRNAAPPVLPLSPASEAPLVGLAFKLEEGKYGQLTYMRVYQGTLKRGNLIFNARTGKKVKVPRLVRMHSNDMEDVEEIGAGEICAMFGVECSSGDTFTDGTTQLSMTSMFVPEPVISLAITPEGKESQNFSRALNRFQKEDPTFRVHVDKESNETIISGMGELHLEIYVERMRREYNVPCTTGKPRVAFRETVEKKATFAYTHKKQTGGAGQFGRVMGYIEPMEVDPETGVDTAFENRVVGGSIPNGYIAACEKGFYDALEKGALSGHAVTGVRFVLEDGAAHSVDSSELAFRLATAGAFREAYQKANPVILEPKMTVEVVAPIEFQGAVIGALNQRKGTISDTEVREDEFTLTAEVSLNDMFGYSSQLRGLTQGKGEFSMEYKCHTPVMMNIQKEMQEAYRKKQTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIV5</accession>
    <name>W3VIV5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIV5"/>
    <dbReference type="HOGENOM" id="CLU_020349_2_1_1"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="181"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="483" mass="53524" checksum="2D7934F4871C6D06" modified="2014-03-19" version="1">MPAASRTGSQLSIVSPTGYTASSCGYCTAPGSGTRSFTKSSRSYGIWAYRLSPYHYQTLIDQGWRRSGDYIYKPDVLRTCCAQIPIRLAVDEYRPTKGQRRALTQLLFSVRRSKPKPARWKGKWSRDRDWDVERRWQEVVPPSDAAEGSSSGSSSAWADRVAGPITNRLEARLALSSFSAEKYELFRRYQGKIHGESEEDISSEKGFRRFLVDSSLTLTWPSVGQPLTASQESAVRSQSWSTCEISEELPYGCYHQEYRLDGKLIAVGVLDILPKCVSSVYVFYDPDFGELQLGKVTALQEIALAKRLGRVEAMREVAYYYLGFYIHGCQKMKYKAEFGPSQLLDCSTNTWMRLADVAAKLEAKQCFEWSSASAHAVGTRDGCETDEGQVRVPTQPRPPPGMLDAQAMLGALNSLVRGGSAGHEASLDLVQAALVLEAQRQEEGINLLLETATAQDDCELVQAVECIAALANAELVSSMVLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIX8</accession>
    <name>W3VIX8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIX8"/>
    <dbReference type="HOGENOM" id="CLU_099502_3_2_1"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="117" mass="13074" checksum="1345559DF3601DD0" modified="2014-03-19" version="1">MASQFINWIKSPAGRQYFFSTHFWGPVANWGLPLAAIADLSKDEEMISGTMSGALCAYSSVFMRFAWRVQPRNYLLFACHATNATAQAVQLFRFANYHHLGGKEKRQSLPSPQVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ36</accession>
    <name>W3VJ36_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PaG_04284</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the MCM family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251904_0_0_1"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="22">
        <location>
            <begin position="1026"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="60"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="559"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ETS61535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1440" mass="157823" checksum="4499D5C8B0280F31" modified="2014-03-19" version="1">MTSNQLYQDAPGLEPQRDVKAVAREHCHTDQDDVARELEAGRVEAAADDEFAMEDAETYGERLTRVLTGEADATQPSSARKDGGSNRAPRSKLALMRRRKADAKRNKASKAAWRTGVRERAEELARTADSEKATQARPTQSAASGTSSTQASDVPHRIKMVGDDGKPMRRHGIRERVLHFTPSWFSVTMGTGVIATLLNLLPWPSIHSGLRYPAAVFLLADIVIFIVFLCAFLARYVMYPEVLPLTIKHPQKSMFLGTLPMGLITIVSGIAQLGTVEFGLGVGFALAASGVWWACVVLSLLTSIGVPFSMMTYQKHYFEGITAALLLPIVPPITAAATGSVLAEIFIERYPTYAFTIMVVSYLVLGIGLPLALLIQVLYFQRLLLFNSPPRDVIISVFLPLGPCGQGGYACLHLGRVALQLFPLISTPASSSGVPQLFSVGQALYGAGLISAMMLFGLGMWWLVIGVCTIIRELSHGKLGFNMGWWGLTFPSASLAICTASLAVELDSLALKITYTALVIANIALWTGSYEVLRLVCYRLVFAIGVIVSQWSMVSSSETRRPNSEKTRAESETRVGHSRTPRSTAANIASDTPPLPKEGLVAMAASAPILPTISINVDYDEERQKITDFLCFFKAPASRLTTLVSHGAGAPISLEDADDDQDELERELSGAIDRMDVDRSAAQRRSRARAEAEASSSRQVPFYMHQLQNIANREQDSLVVELDDVAAHVNTTTGESGAQLVGAIRSNAKRYADLFAECVDRLVPEPSKDISHKDDVLDVIRHQRMERNARTVESAQDPNDTGVAPEDASDNVFPPVLLRRYTLYLKPSTRRVAGEQPEEPLAVRAVRGSHLGKLITVRGIVTRVSEVKPFLLVDAYACDVCGAEVFQEVTSRQYMPLTQCNSRKCLTNNTRGPLYPQVRASKFVPFQEVKIQEMADQVPVGHIPRTMTIHVYGPLTRAMNPGDVVHVGGIFLPMPYSGFKAIRAGLLTDTYLDAQSIHQLKKQYTAMQRTPEIAAQIAELKDDPALYQKLASSIAPEIYGHEDVKKCLLLLLVGGVSKTVGDGMKIRGDINVCLMGDPGVAKSQLLKYISKVAPRGVYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGIACIDEFDKMEESDRTAIHEVMEQQTISISKAGITTTLNARTSILAAANPLYGRYNPRVSPVDNINLPAALLSRFDILYLILDTPSRDDDERLAQHVTYVHMHSAHPELEYDVISPTLMRHYIALARQKRPVLSKAVSDYVVGAYVQMRNQYKEDELSTDSTGPSSSGTGYVSARTLLGIIRLSQALARLRFDDQVSLPDVDEALRLLEVSKSSVLNHPSLATRDVAQDHTYISKIYRIIREFYNTHTAALADDDAMDIDHAIPIPQLRARILASGFVEDQFQECLQEYQDLGVLQVSANRLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ47</accession>
    <name>W3VJ47_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ47"/>
    <dbReference type="HOGENOM" id="CLU_064549_0_0_1"/>
    <dbReference type="OrthoDB" id="3339789at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="355" mass="37475" checksum="57DEC852DE74087C" modified="2014-03-19" version="1">MVSERLALLSITNVGNPPSHLSPLVDQGIGSSDTLDGTLPQLLSHAMSAPIRNVPRVASRAFSHSAAPQVSRTGSTSSSASTIGSSAPSAARSKHLKRQQRSKDDVLRRAVELYHLTPSFLPTAPRGVLAASLSGRSSAPSASSSVWDASLDTAIYASILNTDSVSRRSPNLVARGLPEYSREQSSRAASVPAFGNTGSHSSSNAKDVQSFVSDLTSTTFLTRREREAAAAAAKSSTTESSSSAADPSSKPKKGGLRSFSDADIAMYERRHNNATGAGVSAGLDNSRYSGAERLTHLDRVTPGANEWYRSQGLNTRSARVRDAIFGTVNGELPGLEIVRERIAKLKSQTPSEDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJA4</accession>
    <name>W3VJA4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Squalene monooxygenase</fullName>
            <ecNumber evidence="14">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_04806</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Endoplasmic reticulum membrane</location>
            <topology evidence="3 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJA4"/>
    <dbReference type="HOGENOM" id="CLU_026390_0_0_1"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="15">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="16">
        <location>
            <begin position="177"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS60887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="574" mass="62106" checksum="06D09719C6A5006B" modified="2014-03-19" version="1">MAPATASTRPDIIVVGAGIVGSALAYSLGKSGRKVALFERDFDEPDRIVGELLQPGGVRALAKMGIVDTLQDIDAVPVEGYHVFYGPRSVPIPYPNEKPDEAGRGVVSASGKVEGRSFHHGKFVQSLRNKALNQSNVTPYEATVRDTLKDASGTVVGISATWKKAPEGQPDAFELRAPLTIVADGCFSKFRRTHGSSIQPTVRSNFVGLELEDAPLPAPHHGHVVLSKSGPVLLYQIGSRSTRILIDVAGEKLPSVAKGELQKHVNENVIPQLPEQLRECVAKEMAKGQRLRSMPNSFLPPSMQGQSQHARGVIVVGDAMNMRHPLTGGGMTVGLWDAVHLTEALGGSAWTPLGGDAPARKPLDLADWSTLTPALRSWHWNRKGLASVINILAQALYSLFGADDENLEVLREGCFKYFEMGGECVNGPVSLLSGLAPRPMLLVGHFFAVALYSIWALFAHPRFYEAEKRTRTPSVLEYPALVWRSIMVFWTACVVLLPVVFTEMKANVPRLSPATSVKGAKGSHRGFVTDNFGLVSASILLIGTIMLWGNTRDPATARNLSNWLVFPKVAARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJE6</accession>
    <name>W3VJE6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJE6"/>
    <dbReference type="HOGENOM" id="CLU_891364_0_0_1"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="15"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="315" mass="34224" checksum="41EE67A09821348D" modified="2014-03-19" version="1">MTRILDPEHASSHGTPVYVTVWDLTPSSMWTSAARGLGLGIFHTNVWFPDLSVEWAFGGHGYRDVSGIFSIPRDPIVLDAVHERVLAAVSDDSAAVLAEKSYTLDGLSWLRPEDIPAPGSPPLPGAQYMGAYFVGYAGRVGQPSRPHAEVQPWASAQSGKAAFREPAALVEPYFTHASSVLARRGGATYLHSISATPQSPSKHAEGRSDGRHPRHRGARLASVAHVQATMQELRNDADWMGPTYDLVSHNCNHFADTVCRRLTGAALPAWINRSAALGRNLIWAIPKSILDIDTRVPLEDDDLTDLDHATTLDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJI8</accession>
    <name>W3VJI8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03908</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJI8"/>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834578" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="563"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="625" mass="65307" checksum="6AFBDF35FB52E304" modified="2014-03-19" version="1">MQLSQSFAALAVLLVCASSAFGAIVTDASSLSGQSYDYIIVGGGLAGLTVANRLSANFNTSVLVIEAGNDDRNNPDVYNVDNYGKAFGTELTWHFTTVPQIGGRTKAPLGGKTLGGSTSINGAAWNRASRAQYDALGGLVGSSGWSWDSLLGYMKKSENFIAPNSAQQGAGARYDASVHGSGGPLEIAFSQIRNQRRSGGASQEWRRMYTGPQQAAFIAAIGETLGVQKVDDQCSGSANSVAYTPNSIGTNARRTSSASAYYTPVQNRENLTVLTGTRARNMLWGTQSSSGLSSSGVVVQQSHDGNLVTLNAKREVVLAAGALNTPTLLQRSGVGAKADLDSIGVDQKLALDGVGKNLQDQTMTTLGSRANVNYNGGGPSAAIGMPNVHQVFSNATAVRGYISSNLDSWADTLVSAGHVASKSGLLAQWNSAVSLIFDQAAPIVEMFFDTGYPANSYGIDLWTLLPFSRGSVRATSGNPFDAPRVDPNYFGLPIDMDMQVQSLRAARRVLKNSHLKSLTYNGETTPGFGLIPDGPNSGSYAKWRAWILGTLQGGGSGFSAVSHQLGTAAMAPKQNGGVVDGNFKVYGTTNVRVVDASVVPVQLSAHLSASLYGVAEKAADAILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJV3</accession>
    <name>W3VJV3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJV3"/>
    <dbReference type="HOGENOM" id="CLU_041299_1_0_1"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="416" mass="45278" checksum="57BC7F73CD6ECA56" modified="2014-03-19" version="1">MSNPPATPRSASQPAASLLPDWPQAPSPAYALAPIRISTARASSVRSASSSPRSLTHERSAPYPSSRPARTEMLDVQHPHHPQQAARMHDSELYRTRQALQSHLGVRQPSSSRSAPAQQPHSAEYAQSSSTSSNSQSSSKEAQHKVYLLNCKHCGNFLSDRGMKAVLLLKPNITLYSTDIVPSTCGPFTAASAFHGGADPNEPPVERTCDCLTQSLGCYGCGAQVGYNIISPCTRCTSSVMKHSRSSNGHRTVLHCSEIAVRERRYIPGEPGVRAQPPRVMQAVATHSPMQMYAESRFDAAAADLFRHSNASRRDVHRMNVPSFDDDDLEAEKAEANAALAHQQYYQQRDYRQAGHHGRAHQPPGYAGSQRSSAASGSGRVLRRGDTLFWSDLVAGGERAQPFDPDPILERPTVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJW9</accession>
    <name>W3VJW9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJW9"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="44"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="523" mass="56261" checksum="70789C21995165B3" modified="2014-03-19" version="1">MSTSSQSNSSGRAPAPVTISTPTGNKWQVPSGIFINNAFHASVSGKTFESVNPATGEKLCTLALGGAADIEAAVKAARTAFDTVWGKRSTPTQRSRLLLNFADLVDKHLDELSELESMDNGKPVWMASAFDVPDSAGCLRYYGGLADKIEGKTIEQTEGEKIAYTRIEPLGICGQIIPWNYPIQMAAWKLGPALAAGNCVILKPAEQTPLSALKLAELSVQAGFPPGVISVVNGYGAEVGEAISTHMDIQKVAFTGSTATGKRIMKAAAESNMKKVTLELGGKSPVVVFESADIEQAVRWVCLGILFNQGQDCTAGSRLFVQDSIYEQFMRELVAAFKAHKVGDPFHELTFQGPQVSKVQQQKILDMIESGKRQGAKVEVGGKAWQSPDAKFRNGFFVEPTIFSGCRKGMRIVDEEIFGPVLAVAKFSTEEEAIKLANETEYGLGAGVFSENASQIQRMVSAIDAGTIWVNNYVALSNSVPFGGMKASGFGRELGVDAVKAYCDVKAIHWNYGEKLDWPLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJY2</accession>
    <name>W3VJY2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_05065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJY2"/>
    <dbReference type="HOGENOM" id="CLU_016316_3_2_1"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="601" mass="64900" checksum="744F427133590542" modified="2014-03-19" version="1">MSASQPIAILSVYDKTGLLDLAKGLNALGVRLLGSGGTAKLVREAGLPIGDVSDITKAPEMLGGRVKTLHPAVHGGILAQTSKPSDVEDLKAQSIEPIDVVVCNLYPFEETIAKEPKPSIAQATEEVDIGGVTLLRAAAKNHERVWVLSDPKDYAKFLDNYKSSNAEAAKANRNLLAVKAFSQTAHYDDAISNYYRQQYASLASNSTDVVQQLPLRYGANPHQKPAQAFVTAGEMPVKALCGSPGYINFLDSLNAWALVRELAEATGLPAAASFKHVSPAGAAVGVPLTELEAKAFFVDDLGALSGLATAYARARGADRMSSFGDFIGLSHPVDVQTAKIISREVSDGVIAPAYEPEALEILSKKKGGKYCVLQIDPQFEPSDIETRTVYGVQLQQRRNDVKITKDLFTNIVSDNKEVPEQSQLDLLVATLALKYTQSNSVCYAKNGQVIGLGAGQQSRIHCTRLAGSKTDNFWLRQHPRVLSLPFKKGTKRPEKSNAIDLFVEGTENLSAEEKAEWEAVFEQVPAPLSAEERKQHADQLTGVVCASDAFFPFPDNVHRAKRSGTSFIVAPGGSVMDDACVATANKYNMVVVRTNLRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK09</accession>
    <name>W3VK09_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK09"/>
    <dbReference type="HOGENOM" id="CLU_016218_4_3_1"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="593" mass="61587" checksum="17B878BBA81D1D4C" modified="2014-03-19" version="1">MTASTTLAGAGLPTPKLAHHAPFETIIKEKSSQKLLIALSLQLRRGQITGPEAVSEATAKTLRSVVSSAKYSSMQELIDIIKAAGRHLQLSQPAEQSIGNITRRIVHLLREEAKAALIEAREKELESGRGSGSGSGINSLSNSISDLHLASAFGAPVPGHSAAASGSHSSGPIGQSPGARFNRSLGGSTSHSQFPSSSSSAGVGVGSHSLTRPGPNPLRGGSESGPASSGSSAFVHGSFSISDLVAAGAMAASSSSSLAHTPADGSYASTPHASLSRKGSGVFDSSFSQLQQHMSTVSLAEDAAGEAEAEEAESRSRRSTLRAGDDETESESDEDDEDEDDEDDDESDQGEAQLITGKKSAGAYFLKPLLIQAIQDLIDELETVDDNIAKVSRDHIHSGEVILTLGASATVQSFFLAAAKDRKFTVIVPETAPSYAGHDLARALSQAGISVLLIPDSSIFGVMPRVSKVVLGAHAVLANGGLMAHSGAFATALAARQHSTPVVITTGVYKICPEWSEIQTFSNAASVGALGPAALMHYATSTSIVENTEIASNALDYVPPHLVDVFITNVGEHPPSYVYRLVKENYHADDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK16</accession>
    <name>W3VK16_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05041</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK16"/>
    <dbReference type="SMR" id="W3VK16"/>
    <dbReference type="HOGENOM" id="CLU_014602_0_1_1"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150136" description="Lysophospholipase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="89"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="716" mass="76491" checksum="6A46BB5F36074E3C" modified="2014-03-19" version="1">MKLPLRTSVLAVLAAAAQWVDAVPSIPHELNEREIARISQLPRHERVKLAERILEIRTAYEYEKQLAARQDALEKRASPSGSYAPANMPCPNTTSQQGPGFIRNARTKQLNADEANYISRRRTQSQQAWQEWLSAAKLDSVLPGGASNYTSSSDRLPRLAFALSGGGLRAMLVGSGTLQGFDGRNATANQRGTGGLLQLAEYVAGLSGGSWATASLAMNNWATTQSLKDDVWNLESNLVVPEDGKVSFYASIVAAVAGKRTEGYQTSLTDYFGLSIADKILNGSTYGNKFSVEWSDVKNTSSFTSASMPFPIIIADEREPGELIIPRNTTLWEFSPYEFGSWNPNVSSFIPIEILGSSLNNGSSVLPGGECVGGYQTVAWVTGTSATLFSGLYLSLVSSSSDSVIVNALKEIAQAVSNEQNDVSTVPNPFYNYEGEGDQTLEVTKLMNITLVDGGLDNENVPLWPLVEPARGLDAIIAIDSSADITNWPNGSALYQTSLRAQYPTYSQYAFPVVPDTNTIVNRGLNTRPVFYGCNANVNVTNADTAFNGSKTPIVIYMPSYPYSALANTSTFKLDYSDSEAQGVIDNSVDVASLGGADSQWATCLGCALAQRGFERSNTPRPEVCDQCMKKWCWDGITNTTTPSYSYSPAIGVPQFVTSNGSLQATPPYTGGNGTNSQAGDASSQSAAKNAAAVQSPALAIAIAAAAALALPLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK54</accession>
    <name>W3VK54_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK54"/>
    <dbReference type="HOGENOM" id="CLU_272514_0_0_1"/>
    <dbReference type="OrthoDB" id="3336072at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1170" mass="126003" checksum="4CF670F4361A665F" modified="2014-03-19" version="1">MALHQLFTLAFALHLEPLPTLDYAAVPYIKDPAHSSESLHETDNLRVGANTKLEPIHTRHLPHSLDTLSFLLNHTRAVDAVEPFAKLIELLDDADDDPEFRNLREFFDARYNQDGSLTGADKEPRRRIRSVSRAASTKQPGRRPSQATDARKSSFATSLGGASALKLSWLRRGNNPGSQNHDASDDEDSHSRVSSSGHAAHPPPPTAPYIRLAKPKPSSSPASSTSSSSHRDSESSNTITFRIRLDLHAVGLAPPPPKPRSHRHSDASALSLQRTSSAKSATSSDWRRRRPRNSSLSSGGAALRPVTSPDSLASFGAVSSIANGLSDQQLASISTAQDAQTATKRGLSLPPEGIDNNLPSITEGTVSSPTQLTGHSESVSPTTPQQPASPTTPTKPARRPSMMAKILEFGRKKSFLDRSTGDAHDDAADSKSSAHASDAVTRRSSFRSGFRQQSANQTPCNEEAIDLDEYDDDAALRAQMMRNSANGASAQGRRRSSAGSSTRDAAFLRHAPHDLRPVQEGGMLDLTTVSSRSSIGTSLSDHAIPEDSATGTLSAERTSKSPSRTRQAAALNEGHDFLSLFRAASILGLKSIDDDDDVPSTTTPNGDDLATPGRDGAELRSPRPTPTQAGETSSTHSPSIRTPQVHPKRTSLPGTPGRSVRSLDLDRSPRPPSSGTNPIDANFKLGASLANKSGGDEDEACGGDEDEAWWPCGDVDPLPISISSALGQALGWEGIMHLCYGKGSRAEEDGKYVALGKAAALDQATKVQERNVLAWRTGVASAGTSPPKPEAPMSIHELGVADAAALDGNFAQRLNLDPAHALPDTTKTSAVLERLQAKTPQRSTTEPSAAATEWQQASLLFGTRVNHARTWEHWRLLFMSIKGWMDEYEKTRVRSGLAREIGLDRPVDAPAREEDGDASVLLAAPIDIEGGSELQVPVVGSPPSHAHVLKLARDKVDVSTISRVLGTSLSVPPCVLADATNRAHGFRRRTGIPEGLPLGPGDEEAIEYTWSRKQLSVEHFATALTISTDSALHYFAQLSVGNWLHRSAWELDYLEMCVFKSPLVADRFPPPGEAVVEASQSYRAREGEEDRSRLCPNPDERGAWDPDTWKTWLAGIREGDIIVPAVAWQAWWTLISVLNGADRSGRAYDLQVKTKDEPFEALTDLNAVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK63</accession>
    <name>W3VK63_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_05152</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK63"/>
    <dbReference type="HOGENOM" id="CLU_076902_7_2_1"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000044">
        <property type="entry name" value="Probable U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS61192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="82" mass="8871" checksum="8FB6CD7A2F61965A" modified="2014-03-19" version="1">MSATQSSKAGSPNDFLKGVIGKSVNVRLNSGIDYQGVLSCLDGYMNIALENTTEYVDGVKKNNYGDAFIRGNNVMYITALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK73</accession>
    <name>W3VK73_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK73"/>
    <dbReference type="HOGENOM" id="CLU_008279_11_2_1"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02660">
        <property type="entry name" value="Peptidase_C19D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000546">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="302"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="760" mass="81297" checksum="2DB0937115ACA1CF" modified="2014-03-19" version="1">MPSSTSSSPTKLGGAWGSSQRSNGGSVSPTKPSSAAASRAGTPSFSKPSASSGTVRQIPPGCSHLSALLQLPTASKPAASATKIKPEDADDARTTSFDTLPAATRTYVKRYVAGLRWGARIRAGSVRMMDDEEKEAEQAAWNERAAAAAKQGKPMRKRRKLDHPQCGGCHTEVLRPFICLECAHTACFSPPIDDDPTAVTRTLADSHMVQHLRSAKHTFAFDLLYGHVYCGECKDFVHDPLLEAIQRLETARVQPNGVGQQYGPPKSTIEALFAPNGAADASSALARFYETDAAGVSCRVPRGLRNMGATCYMNVIIQAFLHNPLLRNFFLADRHNTALCTAAKTCLACEMDKIFSEFYSSDPGGLAAATSTGPAAAGGAGAENGANGVLAKGPHGPTSFLYCLWVDQASSELGQAGQHDAHELFISALNSIHTALTSRALERSSLPTFAYEHADALNLLFDHYDGNGGSGHQSEDEAGYGGTPALLGGGGGGGVAGCPCVVHRTFAGQLQSDVTCQRCGKVNTTRDPMLDLSLDVRPESMRRKDGWTGAAGGANKAKLLNGKLQTTGAAGGEADEEQHLTICLQRYCSEEKLGNNDYSCTSCGGSASATKQLSLYRLPPVLCIQLKRFEHTSAAAKIDTKVRFPPVLDVRQFCTAEIRAPDENAPPAPVDVRSSSNSGLTPNPDPEAYLYDLFTVVVHEGSMNTGHYTNFSKWRGSWFRFDDDKVHPTTEAHVLQARAYQLCYKRRLLKNVTNSRSHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK90</accession>
    <name>W3VK90_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05122</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK90"/>
    <dbReference type="HOGENOM" id="CLU_105983_2_0_1"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="87" mass="9739" checksum="FDA192CF6093573A" modified="2014-03-19" version="1">MGKRKSSSKKPTGSKRPPPLDTVFTCLFCNHEKAVSCKIDEKARIGYLSCKICGQKFSADTNPLDQPIDVYSLWIDACEDVANEQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKG8</accession>
    <name>W3VKG8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKG8"/>
    <dbReference type="HOGENOM" id="CLU_2224349_0_0_1"/>
    <dbReference type="OrthoDB" id="10282833at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="106" mass="12163" checksum="D32D2F2A4D931749" modified="2014-03-19" version="1">MDRRSVLVFLNISPSYFNEELAFFTEHARAEGRTLVPYTHPDYPGEYGYVCTGADDSLVDSAKFLVRRHDYIRLWVFSESDFVLPREINNSNSLDNLVSSHRALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKQ5</accession>
    <name>W3VKQ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003808_0_0_1"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="645"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1311" mass="139462" checksum="18E1CE65248E8B89" modified="2014-03-19" version="1">MSAPTDSSPLGPPTTIQTQAEPSSSSPPAPTPVSEPSPSQVSTESPTDIESPVVPGAFGSSIASAPHASTPPASSADASANTPSSTSSQHSDHDKPLPSISHDEASSSDAGTHIPPEQPSLAPSPPEPQLTSSIITTISPVRRSVYKRKMSSKPKGILKPAPPPQKGFSFRRDILENINSRLAQQGVNMQVPLPQGSTAQATASYIGGMFRRIGGIAAGAAANVGGANATSVGGLLSNDSPSKPNAASATSNRSASTTTFGSSSGFAMASSQTVESEASSSSSSTLIKSNIAAATTSAAPLKKVQFQVSHMAVTYPIVGAGTPEDEDLTRLRIERQHRRMLKARRDKPWTPEELEALYRECCRTREEHPLKKMRLVFQEAAQSSPPALKTLDLSFVPLDRQAVEPIADLLSIDFGLNKLVLENCALTDDSLKSILHALLVSGTLPNLSIASNRKIRFRGWRYLAIFMRRARALRYLDLSENSIDRASLEHLLAVITKPAAAVTQERASKQVPTGKAASTGEGHGAKGGEAAAATGTKTNGQEAGIVFNGGDSEADEDDDDEFFDNSGEPLMPTAPLLREVSDDPDPPSSAVISLRLENCGLKAASLEMLSQSVRFSDIRHLSLRRNKIGQLASVALAIMLKDYPDMPPHDPTSTGTPQREGKSYFDANGAPATPSKSQVDAFDRSGRTPRPTDAQSSPERRTRSYSPGLPEVPVIVSSPGGGITSRKMPSQMYANGGAGGHQSTTFYGAHTEQLQDAMQTSIAGPGRELDSQITPQEALEIRRKLAPGMSEEEAVSIYQAKRARRILAELPRVGNLLTLDLKSNDIRGGVVYLAQVLKKNRTLRVLNLSDNNIEMPGLVAIAEALKYNSTLETLDMSHNPCSGPGLEGITTLRTAFALNSNLKRLFLNDTDLSSEAAIALAEFLPEARSLIHLDLAENFEIDIAGVMALAVSLRMNRSLRCLDLNIPPNNPDFARLSQEILQSCVRNTELAQQRATQKGLKQPIAAPIYKSVVARAARENDERIKAIETARATAKEAAAAKDRAAVEGLLSASVECQNVLRDLLTGEEKRQREAPEQKVTPPGDSKLRRRLAELAGTVEDETVLARILAVHDELGDVSKRLEEFYRYGSAPAIDVRAVDAGLQASGVVGTSASAASMQHLTTPDQAQMESGLSSPAFSIADSDESDSDDGAGSAPAKRAVRSQAEAKDEVVGRLHGLRIDTTAADREVPEDDGCAVLARSPGEDRAKGQLSEEAELFRKARSLGLDEDDDARAGDSAQDESGEQLRQDLLQADVPPKSSAPADEIQTDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKW0</accession>
    <name>W3VKW0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKW0"/>
    <dbReference type="HOGENOM" id="CLU_035750_8_0_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="282" mass="30913" checksum="4E0AE019931A2A2C" modified="2014-03-19" version="1">MFRNTYDSDNTVFSPQGRLHQVEYALEAVKQGSAVVGLRSNTHAILVALKRAPSELASYQKKMLRIDNHMGIGFAGLTSDARVLSTYMRQLALSSRLVYSRALPISRVVDSLADRAQYNTMDYGKRPYGVGFLIIGVDSTGPHLYEFTPTANCFEYYAMSIGARSQSAKTYLERKYEEFSDASLDQLVLHGLYALRDTLPQNKDLELDQVSVAVVGPGADADVDSPNARSGEKFRIVEGDELRPYMDRLEPKSIPGVRATAASTESADAAPAPAAGETPMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKY6</accession>
    <name>W3VKY6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKY6"/>
    <dbReference type="HOGENOM" id="CLU_025603_1_1_1"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="500" mass="54176" checksum="212F75516DDFEBB6" modified="2014-03-19" version="1">MSIPSVDVSSLKQRYEKAGQSHLFAFWDKLNADEQAQLAQQLDELDVERVNQVFHTAIKADEEARAGKSHDVQPPPPSSVVNTIHGEAEPAKVEHFRTVGLDAIARGQVGVLLMAGGQGTRLGSTAPKGCYDIGLPSHKSLFQIQAERILRLQHLAAQHAHSSASGSANGNSAAVVIPWYIMTSGPTRRDTEAFFAEHKYFGLQKENIIFFEQGTLPCLSLEGKILLDSTSRVATAPDGNGGLYRALRTPYNKGQPHTVISDLEKRGIKYLHAYGVDNCLVKVGDPIFLGVCLEQGVQAGVKVVKKENPKESVGVVALRDGKFGVVEYSEIPESLSEARDANGELSFRAANIVNHFYTTKFLADDVPAFEPEMAFHIARKKIPTVDLATGSPVKPSTPNGMKLELFVFDVFPFCGDKLAVHEVARPEEFSPLKNAKGTGVDDQDTSRRDLLAQQSRWLAAAGATVSDGTEVELSPLLTYTGEGLESFAGKTLSQSGNIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL33</accession>
    <name>W3VL33_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL33"/>
    <dbReference type="HOGENOM" id="CLU_1993581_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="125" mass="13094" checksum="56537496F3D93C7B" modified="2014-03-19" version="1">MPLSSSASASSCAERPYYSNSPAASISSSSVCSSMSYAHSSAMSATPSPYASRSTISGRTTPDTPPSDLDSTQWEDARFYGVDLKAELSPSSTGAYKLPHQAAAPGFAQHASAADSYLHPYSWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLG3</accession>
    <name>W3VLG3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLG3"/>
    <dbReference type="HOGENOM" id="CLU_007002_0_0_1"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000905">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="239"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="431"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="783" mass="87720" checksum="79947FB198C8418E" modified="2014-03-19" version="1">MFMLKSLFGKIWGDSNNQELIQIPAGALYLVRPTNGPQGSRECIYEDAVLAIRRTTSEFHYQLVVTKAFQDSQPELVDQEEDDLEDERAFLIDHALDFRLSTRGKERTLVWRDFDGDQDDLLEFVIDNKQVNEVTITIFEITYLQCVYEHAFRTSHERASEEDLDKLRYKDEADQKLKREQKDQLDKKLQDAGIGSNDASASASASASAAKQEPAALEIAPTVAPAADTAGPQIDENSIVFSAKADLYLYDLKSQYFLVQERKVDIKVVEAGRFLFWLSIQGADKTWLAQKVESDMNMNFSPEQTSAVWNYFTDDRQCFSWLLRFEDKEAYAHFHKGFSQVLYETQNEEPWSKAKSDDRAYAETAYEQGEPMDLDDISESEAGDESVRTARQDEEEDEEEEVAAELQSGGADSDQAAWPEETSLLAGKQDVNSLLAVGYKFDRSFVARGDKIGVFRHTDDNRLEFDTTINNVGTPSGKGFKPLKMMLHNQDAQMVMMDPSNKHALYNMDLEYGKIVDEWKVHDDVQVSNVVPTSKYAQMTGEKTMIGHSQNGIFRIDPRLGGNKLVDSQFKQYAAKNDFSVAATDDKGRLAVASNKGDIRLFDTIGKNAKTALPALGDPIIGIDVSTDGRYIIATCKTYLLLIDTLIGSGRFQGQLGFDRSFPADAKPQPKRLTLKPSHVAFMGSEISFTPARFNTGTGPNAETSIVTSTGPYVVSWAFKKVRNGELGSYVLKRYGGEIIQDEHTYGSDQAIVVAFEHDVQMAKRSQLLKPTRKSLAPAGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLQ2</accession>
    <name>W3VLQ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_03225</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLQ2"/>
    <dbReference type="HOGENOM" id="CLU_001805_0_0_1"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000055">
        <property type="entry name" value="Related to mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000061">
        <property type="entry name" value="Related to mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="15">
        <location>
            <begin position="452"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="80"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="693"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS62588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="987" mass="107696" checksum="11978BB35D39EAFA" modified="2014-03-19" version="1">MRSASGAVHRVPDAEPHRLPSVRDLPIPATCRQILNPSSASASQVRVMTAKRSTEKFLRSFAGWTDIRLSSCAASCLTSTPSQADGLSPRQYKPSAMASSSSRLARRATASITRSSGQSISRTALPLARSSSRRSTFTPESGPSTPLLSRRSRRFSVSATARRLQPAAASRTADFGVAKSDHEKDNEELRALFDAPPSSSSANSLRSSGPSTGLFEIPTLTSPQNFLILAQQTLARAQLLVDRIDRAGHVDATTAEGVKELKEVVRNLDRLSDLLCGVIDMAELVRNAHPDPEWAEAANAAYEYLCGYMNVLNTHVGLYSVLKNILSTPDIASTLSSEATAVAQVFLRDFEKSGIHLPPAEREQFVKLSDEILVLGRGFLQDIAGNDASDDFSRSATAKADVDPNDTVELPTDWLQDVNPTVLKAVRASAITDRDGLLTFSAADQPWVFQTLLKYAPDERARKAAFRAANYGSQAQVQRLERLLKARAELATLTGAGSYAEMALGDKMAKQPQNVEQFLRALTNHHRPRAAKDLDKLRTLKHTASVAAKSGNKAAGGIFNPAPTLPGFAPWDRDIYTEQHFRTPSLRSVQPLSPYLSLGSVFAGLSRLFSSLYGIRFRASMVAPGEVWSEGPGDVMKVEVLDEREGARGSDCSAEGLIGTIYADLWSREGKPGGAAHYTVRCSRRVDKDDEAGDFAHGRAEDGRVLRPEDLGGQGYGNPLQAPTFEQRERAGRYQLPVVVLMCDFARPGGGGGQGPCLLGWHEVETLFHEMGHAIHSMIGRTSYHNVSGTRCATDFVELPSILMEHFVQSPQVVSILARHHKTGASLPFEHLQAHLQASKSLESLDTYHQILLARLDQMYHSTLAADKGFDSTQAYAALDREMALPGGEFLSYTQGANPQVRFGHLFGYGSTYYSYLLDRVIASKIWNHLFAKDPLDRAAGETFKSQCLKFGGGKDPWHILADVLKQDNIRDGDSHAMQQVGRWGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM03</accession>
    <name>W3VM03_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM03"/>
    <dbReference type="HOGENOM" id="CLU_2062482_0_0_1"/>
    <dbReference type="OrthoDB" id="10491812at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="119" mass="12194" checksum="3CC9F170A8E82C35" modified="2014-03-19" version="1">MVVGRARLERRVTSAALAQDQEGAPGAVPALSAGKPFGVPAGPPFELGNCTLWETPLCLEAGGAVASLTVAEPDIRPTLPAFAGSSSLEFPVSSLGSVIACVAAHTLHAEPALQHKRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM11</accession>
    <name>W3VM11_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM11"/>
    <dbReference type="HOGENOM" id="CLU_1807069_0_0_1"/>
    <dbReference type="OrthoDB" id="2542672at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833344" evidence="1">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="134" mass="14449" checksum="5BCE59EC52BAAB17" modified="2014-03-19" version="1">MKTFTSVMLMATAFAGLVRAGWNPQQPPNYTVSAYCANANAERACFTTDIGDLTPGPGSHFSGFISDDRKSFVLYQDQDSTASLVVGKYIININWATSGNNGQTCCAVDVQTQDGQDVSNYLSCAQAKWFNLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMD8</accession>
    <name>W3VMD8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMD8"/>
    <dbReference type="HOGENOM" id="CLU_319361_0_0_1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="885"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="910" mass="96668" checksum="A87CAFEE6970AA03" modified="2014-03-19" version="1">MTGRFAPARGDVLSLSSSITMVDGRTMPRFGIGAWDMRGAECRTALQHAFRAGYRHVDSARYYRNEAECGASIRECGIARSEIFATTKIYLNDMGGGAKTRSAVEDSLAKWGLDYIDLVLLHAPDGGKRFRLDSWATLTELVQEGRIRSLGVSNFGAHHIKELLDSNPAVRPVCNQIECHPFFAQKDLRAACEKEGIIVQAYCPLARGRYYGDKTLKKVADETGKTEAQVMLRWLIQHGIVALPKSSNPQRQVENANSLKFELSDEQMEEVGERGGGENASRACKSNTSAPYPQPPLSLPVSPHHSDPLEPTLLQPTRAADSSFTPIRKQKLKRMPFLGPEASTSISWNGIVDAATHTTPSTATTDALPGAATWPPSAASLSTAQSHMDSSAPVGIAEINLVSSPPTSHATSPLRPSARNNLPSPSELRAGSKAAFSAATAARLESAFVANSDPEDGGEIEADGADTPRDRSGSPEQEQVPESTVYVQLPASSPSMAVHSGSASRRKSKGASGSDSPKRRRRGSKSSEASQPGASSVVDDAALAAQLAAQEAALARRRPTRGSRKDVSYSPVCDLDGKPLRSKQGAAAAPASSSASTSKDKLKSKKTPTPRKVSGKRRSRVFSDDEDEDEHADAGSSGAAPAKASAAEEEQHDADLTDEDVGFQARDRKKPRKSKRGGAEEAQEPDAARAEASTRGSKGKPRRRRDEDEEEVHTDASGGGGDDGILTPPAPASPRQSGKRNASPKVQAAEPAAKSPASDSQVSKRQSGAEDEQENGDLAASPRASAASAEASASRRTTPATVAIKRVGTTSSPGGSPSARSFFGKPLTSLLTGTVRRPGLTRKTNIPSLLAHRTAPKPPAPKLAVSKRRMQDDDYEYDAAYEALIAKPEPGSDDEDEAAEDQVEHEGEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMJ8</accession>
    <name>W3VMJ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_03554</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMJ8"/>
    <dbReference type="HOGENOM" id="CLU_098726_2_1_1"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="14">
        <location>
            <begin position="35"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS62001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="166" mass="17731" checksum="659EDFE77D89B763" modified="2014-03-19" version="1">MVLNQEKLARLQAASRTGGKGTPRRKMAPKPKGPGGEDPKLQAALKKLQVEPVSGIEEVNMFKEDGNVLHFAAPKVHGLPTSNTFAVYGNGVDKELTELVPGILNQLGPDSLASLRKLAESYQAMNAQHAASQAAAGASKDDDDVPDVVENFDEADKKETEVDKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN82</accession>
    <name>W3VN82_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN82"/>
    <dbReference type="HOGENOM" id="CLU_039961_0_0_1"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="519" mass="56582" checksum="C89B264B9AF189F5" modified="2014-03-19" version="1">MTRKLIRLETTSAARDQIGQHADEPCHFCYAVSKQGSTTTFAPSVEFRCLGYGACCNGCSSTDDTGVAKTEWLQMTMRPASGELARRPSSFPSTIVGQREHPATVLCRRRPKYLTYLQSTAAWSTVRITRSLLDMFVKISWVLCAAAAFQSVYARPLRGTASRLKQGGGSANSSRFHDVPYGRFGPAARQAGSGAPGSDAINEDASGLAPALAPGVQNSLGEGFDPQFLTTTRDGKPFYLVTDVDFGMKVFLRASDDLNDIYRNEGKMFAIYEYSNVSYPKGVGTEAADIVRLGDRYLYTVSAIQDDTMRMLISDTDDPLGQYTDLGRVLGQDGVALQGYDPHVIVHPNGNTYLTWSNHEYVQLVQLQNGAPARAASAVVDLVSYGVNTEAPSSWVYDNKVNGSRTLNLMYAEGNFYQSNYNTRLLYIDAAEDPLDVGRWYQRGQPILASDSSQGVYGPGSGSLFTGPDGQTWCAYGAFASPDGADDGKNERYVRVQVAQADERGVWLPTQVIPAEKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNE9</accession>
    <name>W3VNE9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="10" type="ORF">PaG_03333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNE9"/>
    <dbReference type="HOGENOM" id="CLU_043845_0_2_1"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="434"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="488" mass="53574" checksum="C8572A74EF919FE2" modified="2014-03-19" version="1">MLGSRPMNGDVKLTGLPPIRQASDTCEPPTAGNTAEPEKPSWPAEAAVPYEEKCASARPFRTFDFDGTRVEVQARAAQCRAVRCGAESRWLVGLHCRGEFFSTSGWGSWPGSCASGGVDSQSAAEDHLQSTIFVHRKLATMRPILLSGHERSLTQIKFNREGDLLFSVAKDPVINAWFSHNGERLGTYEGHNGTVWTVDVDSTSTLLVSGSADNQMRLWEVATGKCLYVWEFATAAKRVAFSEDCTQVLVVTEARMGHRGALRVFRINRDPATWTQQSAEPTRTITFSGPKAVVAAFAPCDQYIITGHENGKVALYYHDDKEPESGIDAELEENSTDAHPGEMISDLQMSADRTYFTTSSRDKTAKLIDSKTLQVIKTYATETPLNSASIHPTKPFVIVGGGQDAMNVTTTSARQGRFETRFWHKVFEEECARLPGHFGPINTIAIHPAGTAYASGGEDGYVRVNWFDPGFFNSKLYGADLELALEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNF6</accession>
    <name>W3VNF6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNF6"/>
    <dbReference type="HOGENOM" id="CLU_017666_0_0_1"/>
    <dbReference type="OrthoDB" id="3342809at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37211">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37211:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="833" mass="90735" checksum="5250222CF203DC70" modified="2014-03-19" version="1">MLHAAEQSTHCIGSAVPAIACLLRAAAAPRRTDACLARHLQADSACLRSLTTTAVILGTGRELRRSRSQRKTPVLSRVLLFHRGVGSHAQAVSRATRPWAWAVSSARIRGWPPPNSAPVKTARRCCSLARASDPVSKDSSAVRSPKKCARLPHFFMQSHVGRPISPALPLPLDLNLWGRMDVVCNSRLDPRPAPAPASRSSKRRHRYAARRPSFAHRLACWLGGNACLLSDGAALRTSELVSSPIPVLIQLREGMLSSELGRRKPSFLSSCSSSLDPGSPACSPHTFSSSLFTQPIMAADPFAHARPNWEHISSAPGLDSDRVPLASTAPVLKIYEEAVQEPGVECRNIDSLYSQAQLDGSDRYDARILREDFCSTAIIATTWAGMDARNRSQGVDIDLVALKDTHARLRNRPGFVQLLQSPSFAQDGPYTKVLSAEVLPATGAETEAVKETPQDAAPAADTWAPGAATERFDRKRNKKLAKQAKKDAAIEAARVARAASQPPAADGPKMKLLHSDVLDLPVAPVAAESLDSALEAPDVIASLNYAMAYFHDRATLLRYLRMARATLRPKTGVFITDMFGGPSTGESYPDQDATWARFQGEVGFGRDGGDARGQYVLRADRSRAGLRKDASTHAGLAAIDGRGANRARPARDNDADDEEAERVLELMPAPDSSSLGTRAEWPRGKLKLVRTGEEHGGFEYWREDGPVDWMTNRFRMSLSFRFSDASWLRDVFSYDFRVWSIKELTEAMEEAGFVRVQVHILPRNIVDSDRGDAIDDDASDAASEAADEADSMAGLLLRTEKEERNKSSYTAVKAGEKVFANRSFATYIVACAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNI6</accession>
    <name>W3VNI6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin filament organization-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNI6"/>
    <dbReference type="HOGENOM" id="CLU_324180_0_0_1"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF40">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="180"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="839" mass="91655" checksum="6AE7EDE7A1771870" modified="2014-03-19" version="1">MSSNPANSASASSSSAAASSDESRWKKWGKTAFDKSIVVSDWASGYANSASAKMGGERFWPKSNDFPEEIAKCERILRAFTVEGIETKPAEKKDASEPTSDAEAETDAEAKKKDGFMHKKRKVLRKIPPAVIKRAKGIVIYTAMRSGIAPFGGAGGAGLMLARMPDGSWSAPSSISPNNLAVGLLLGFDIFDVILVVNTERAMESFKSHKVTLGAETAVAAGPFGTGISGEMGIDRSPVFSYVRSRGLYGGVEAMAQAFLHRFDENERIYYWPGITATDIFEGKVRKPPMADPLYRALRDAETGVAQGDSLERWVYEPVHAPPNIAVRQLQQQESAELLQDGERLKLPPTPEELEAMEEAGIPDDFDIALEKREAEEARVRAEQERREIFALPPPPRHKQVERYWESRGTVPGGKRRVAPPPSPLHTEAVVGDRVEAIGEGDLETVDLGEQEKPPLPPRNAKAVESLADELEATGLQDDVPAYEAGEASMPLDAEHTPSSPIKPSLTKELGEDTISRSSSLSRPSRPPRRAARAATAAVTASASPGPATRADGAALQLFIDWDETITATDTLSLIAPPEGEQEHGPAFSHYTEAYLSDLKAYETSFGERNTWDRQLDFLAEMDSVEVESVTRVQDGGLFKGVTRASLLERAQKVEFRTGWQDFYAWLGEHRDVVAEIISVGWSAAFIRHAIESHSPTPDPVIREVWANEVEMDDGVGTGALTKAADTHVRTAHDKVRVMNQRATATTVFIGDSTTDLPSMLSAHFGIIIKNKTDFEESSINRCIQTTKPPLTKLYTDHTEFLDQIASIEAEKRGVLVRVDDWIQALAVIQAIEKHTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNJ5</accession>
    <name>W3VNJ5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNJ5"/>
    <dbReference type="HOGENOM" id="CLU_1225225_0_0_1"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="225" mass="24232" checksum="C871C813CBDC6E89" modified="2014-03-19" version="1">MFHGSNTRLNAAGLAPEHSKLLPERQPKDDEADILNALHELYTSATPSDACFSVFANEAILTLPTGDVVVGPNGIRAKFAELLSSYSQRTLRQRLLVTPESLPHRTMVLDHVLSLSNAGQDIKTVHSLVVLKRKAQDGKISALTEEEGHRKATAPLAARAAAANSFYSPTDAQLSPVTSKLNLAKRKHHMKAKPTALFANRSGLRQAIVPGSPAHSTASNADMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP94</accession>
    <name>W3VP94_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP94"/>
    <dbReference type="HOGENOM" id="CLU_006019_0_1_1"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="887"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="978"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1136"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1194" mass="129372" checksum="5A0B01E234F48DDC" modified="2014-03-19" version="1">MVALITHTISKATMFADLDVLLAIALGGPSAQSDLFLGSRCEAGHTSSHQSIFLALCHSGRRQIEGKAVPANRRAHGERPRQSTVTFPPRPHLPASDIVDSPLRTRNTDSRDRSHRVAAMYQPNLYPHSTAPSADAIYHQHMIPTSVYPTAPHMVATVSQSDLPTAFSNPDISAHAADASIDTTNQDDDGDAGGKRRRVQRACDTCRKKKVRCDGLQPEKGACTNCANYGYECTFIDAARKRAPPRSYVEAIEARIVKMEHLISSLAPGVDFTDRIGKPIRRPDDKGDEAINDTSGAPASTLAGADTATVAPPTCDTQHAMCGTLSHMLAASHSKSRSSSEPTLADQSDEDSEDDIAFIESRIGAVDLKPQPVVPSTANTFDSINSERIILGEGSKADPSSQSLPSHKFIGKASAMHTLPLLERLSSRNYSELGIHPKGARPEFWAIPTGLLDPPADLDAAMAVFPPSDLADKLIDVFFARPNREYPIVNEAQFRHEYANCPELRKEPDWLAMCFCIFTVASPCVDDLRTRASPDDPLSRGMHWWQAAKTLIYRNSQMRKPIRHIQCLLLSTLFQLGLPISASASWLLLGAAIRFLLDVGAHRRQASKKLGLSRLEAETMKRVFWVAYSLDREAASSLGRPIMLQDEDIDVELPVEIDDEYLFSTPEGELLPMQPSDKPALISGFLCSLRLDEIIGRTLKTVYALQKTKIRYGVSSKEWEERLVTEIDSALNNWLDTVPPHLRYDPHEADDEWLIQSSLLYSKYYQCQILVHRPFIPAKKGASESSILNFPSLAICTNAARSISHLTQSLRDRNLHNSTGMSVAFRVVSACTILILVVWGAKRNGGRVSSSATTDLRRSIEVLRSMESVWQFCGKAVDILESIMSSTQTSVTRQASNDQGTKRSRDGSEVVDVKVEGDAPWAQASRPRNSGTSKAAAESGRGRHKASVNSDSPEALGASAQPLAPEARQLPLSTLQLASMTPQSSAEQSPSSATDANPRPTAEAALADPFGPKTPQPPQRARIPSLSGASGLPGALSFGLLTPSAGNWAAGMEADYLQGPHAQMGYQSMPSITPSIFDNLNLPPSTDEMLPPNVSNLAGMSQFNYGASSNSANGLGVQGDAYGNFGRYYGGGDSALGASQGPEDVRAHTGDANTPQSDGSNGLASYAFELLQKQSVWNLDDDSLSFLQQCGQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPC6</accession>
    <name>W3VPC6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPC6"/>
    <dbReference type="HOGENOM" id="CLU_1090396_0_0_1"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="255" mass="27792" checksum="96AB5BF98BF5905E" modified="2014-03-19" version="1">MSFLTGAIRTAAVSTSARAALLGRTAPVALSQQAIRDSTFATSPWICLSSGMSNPESWGPSGPDLVDVEATRSKCTILIPGRDCVQTRLGQIRPAGKSLRSDLLVPVLAIHQSACLHLAITQERPMHLDVPTASTAVATNTAAAAIRGYAAHHEEESFDAFNSRYVGFFDAVEDLFELQRGLNNCFAYDLVPSPEVIESALRASRRVNDYSTAVRIFEGIKQKVENQSQYKQYLDALQGVREELGIKLKEEMYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPH2</accession>
    <name>W3VPH2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPH2"/>
    <dbReference type="HOGENOM" id="CLU_496228_0_0_1"/>
    <dbReference type="OrthoDB" id="2549401at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="515" mass="55601" checksum="91D430C5ABE8BF87" modified="2014-03-19" version="1">MTTSSWQADDMAWRHRILVVVEDDSTNQTQATQFVPVELVRNGVTYIILYSMFATLLFVLLCAVLFKNGLSPQKRRLPVVWVLGLAMLGGLLGSTLNTVFWAYQLFGNVSEDAMFRLWMSSTAMLYIVPLVTHFAIQLRLLAFYPSTLASRKKRIAISILPSLMKVARLTTICITLSNSAKVYKSDGFGYTVSRAANDTSNLLTLIFQLVDTVYASVMLLWRYWHLGRRDSELMSKKSHPALRWAKQIAFAIAFGYVLPTVYALALVLSKALSLSAVDMGFMLVANVYVQAFGAVLASLSSAYKWRDDRFTDSLSPDNAVLPGMRGVGDPFASNDTKHQPAHMRALDSGFSDAGTPTRPSFLNVRLPPLDSRRRAGLTPDAAATSPGLSAIVVDGSAPIKAGDVSPKSSAPAVPTQYPGTPGTAECVSIDFPDTYAPQQSESRRSSDATLFAPGGADKADAASTKAAAAASRPGSRPGSSGTGRIQRLGSSRSVPRQGSLREEEEAPPPSQADSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPN4</accession>
    <name>W3VPN4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPN4"/>
    <dbReference type="HOGENOM" id="CLU_061883_0_1_1"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="248" mass="27243" checksum="4D332D0AACE746DC" modified="2014-03-19" version="1">MSRDPYHDFASDLKSSLASARSLSESYRQLVARSAASSASGAGGSSSRRTSSEIDSAHDRLSDAIEGLRQDVEDVKQSVAVVERSGPERFGVTPDELRRRKAFVEECEAEIKALSKVVKQSAPGGRRGGSGFDSVKIDVDGQDEDATEVFEREQQQILMSRQDSTLDKIGTTLNSLRNQAGMMGQEIGEQIEIIDAFDGEVEQSQGRLGKAMRKMDEVVRISDERLGGWCVWILIVVLFLLLLVVFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPQ2</accession>
    <name>W3VPQ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPQ2"/>
    <dbReference type="HOGENOM" id="CLU_002865_7_1_1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="593" mass="65035" checksum="A5B0D2635C6E5EA7" modified="2014-03-19" version="1">MAPKPNPARPDTDPVHGQTVEDKPANPTPSTSSGPTARERLASLASHLLPGGNTEFDYVIVGGGTAGAVLANRLTEDRNVSVAVIEGGPTDVGNDMVLDLSRWLEMLGSDLDYDYPTVPQPRGNSFIRHSRARVLGGCSSHNTLISFRPFNADLDDWSNNYGCPSWNASNVQPYGDRLKMNIVPVAPQQRNQVARDWVLASSRATGAPVLEDLNAHIVHRGGFQKAVGFFDIAYDPYSGQRSSASVAYLHPIMPHGPYKRHNLHLFLETWANQLEYAANDSSKVTGVKVTTKHGLSKTLTARREVILCAGAIDTPRLLLHSGIGPRKDLEALGLPCKHDVPGVGENLTDHPESIVMWETRDTPPETVMSSDAGLFLRVLPQDAEPNAHPGPDLMFHIYQVPFADNTERVGYERPKHAICMTPNICRSQARGKVSLASANPKDKPLLDFKYFEDKDNYDERILIEGVKWARKIAEQSPFKEHLVKEIAPGPKITNDKDIGEYARKVAHTVYHPAGTCRMGTPAPMHGGKGKDNSVVVDEKDLRIVGLNGVRVCDASVLPTLPTINPMLTILMVAERAAEIIRDDAWHNGLRKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ56</accession>
    <name>W3VQ56_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ56"/>
    <dbReference type="HOGENOM" id="CLU_002289_2_0_1"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046713">
        <property type="term" value="P:borate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF38">
        <property type="entry name" value="ANION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="108"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="299"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="766"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="799"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="888" mass="97334" checksum="21921BC8B5E1B845" modified="2014-03-19" version="1">MNSIDPGSVPALRAVQAERAQNNGTATSTARSSHDGGSVTVGASSQNVSSNGLSNRKTTAKASPSQDVTSSTGGKQQEKRRKRKEAVAYPLFPGDKPWSQRSWAYELRPFRGMWYDLRRRKPFLASDWTEGLEPKNWWTLVNSVVRMYFINLMPALAYILDMNYRTGGSYGVNEVILASALAAIVFPIFSVQPLTFVGVTGLINLVNYTQYNIFVGYYGFDNRNYLRIQAWSLIWAAAFHFVVAIFNVCDFTRFITDMTSETFGFYVGVIYIQKGIELLIEEFEPAPLDNATGWLSVTIAILFTVSVYLVAKVGNTSYLPFRARNFIAGYAFAAGCIFWTGFSHFPKNSLKLVPVERLPITKAFFPTLDRPWFIDFWNIELKYVFVGAPLGFLIMLLFYFDHNVSSVMAQARNYPVRKPAGFHWDFFLLGITTLVSGFLGLPAPNGLVPQAPVHTETLSVYQQVERPEVDKRIARETLSKRKPKMRTVKQHHIVNARVVEGRISHLVIGLLTLGTMTRPLLVVLGTMPRAVFAGIFILVGWASIERNSITMRTLAIFRDRRLAPADEPLNTVRRSKIALFVGIQWLFAAMTIAISATIAGIGFPVIITLLIPVRYFLVPKWFSPLELKILDAPTADADGVLASLGHEPERVTGRGVEIALDTKIAGTLYHKKSLDDESDDDEGEPGGEKSAAQYHADETKHSRSHYDEEARGAEDTSDDEGDAESASSEAREATRTVAGLGGHQTADPVRHVAAASGAGIIASGLGSGAEAAAEDDRREEQEELAEAQDEEAAEKAHESATASSAPAAAGVPAVPAVQEPAEQSTTTAAAGSRFVEQVPAASTSEVATEAKSPRKRRFVTVENPPRGAGSPPPPVQWRGLSEHAEPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ58</accession>
    <name>W3VQ58_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ58"/>
    <dbReference type="HOGENOM" id="CLU_054612_0_0_1"/>
    <dbReference type="OrthoDB" id="2555417at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="401" mass="42805" checksum="C21AB9D8E290BBA2" modified="2014-03-19" version="1">MLRQLNVSTSAPNSACRHTASVQRNLTRSSKQPLASAASTDALCALQPLAFLGRAALATAALPTPLVALMSDLPEDALGLMPILAWTRSTRGGTGGASKISPTDVQIHSFGMTAILSSRFSDSTIASASSSFSRLSAASSASSVEDLLLPSLDAIPKPPPRTSSITLNSTKTYSERRERKKPAPLQLVSSSRPMRNTATTSSISDDGYYSCKEDLRRSGTRAACFCGADVRPSTSSTTSSSTEIYCSRKCARQDALYALEGRSPTMSHLSASSSDIEEEDEDFPVTPTNAFVPATPRAPIAKGRTLELRDRPSLMKKMAGIGASHYRRMEALGLYDADSTPTRPSTSNPLMDPIDLMVAHSPKSKSVSSLESSSDDDDFDFDPRKTLFFPVPIYMGASTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ65</accession>
    <name>W3VQ65_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lumazine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ65"/>
    <dbReference type="HOGENOM" id="CLU_034388_1_1_1"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000016">
        <property type="entry name" value="Related to RIB5-riboflavin synthase, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="110"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="110"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="293" mass="30950" checksum="33D3CA02ED0B7EE2" modified="2014-03-19" version="1">MFTGIVELLAPIIDISPQDATKSGGGGYSMTIGKTATILKDCHIGDSIAVNGTCLTVTEFDADEANHGGYFKIGVAPETLKKTNLGELKVGDGVNCERAMDAHTRFGGHFVQGHVDTTALIRSVVPNGNALTITLRLQHKPESLPLPSSLSPYLIPKGYVTLDGASLTLIEVSPATGGLLPSNSTAGDVREDAQTPKKEIVEFSVMLIAHTQEVIGLSRKKPGDTVNVELDMVGKYVHRAVLGSLERDAEEHESANSVDAGRNVVGTAVGPASSQALEGMVERIVRKVLSEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQJ9</accession>
    <name>W3VQJ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQJ9"/>
    <dbReference type="HOGENOM" id="CLU_002472_8_0_1"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="6">
        <location>
            <begin position="263"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="636"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="588"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="96336" checksum="DBAF849D1DB57C54" modified="2014-03-19" version="1">MSSAPPSDAVNATTPSANARAATHDQEDRASTALRDLPLSAVAIHVQRGHLGCAVFVEEEQQLFLCEDLPCNFFSPQQVNPAPLQNVDHNSELMRDDIAAKATATVHGSAASVLESYEGSAVAISSRHHPGIFDLPGSPPSRFADFLRASVEVRPARDFQLALGLAGIAEVTACTDALTIDGEGLLPSAVLTDAKISRSKATISICSVGPLLSGLRNRLDVGRSLVLSVLSLDEYLFVDENTLRSMSICSSDPHAFVHAKAGREGFTVLGELYTPSMPLLQRWIMLPLANRAEIQRRHDAVELLVRHEAYSEIIEIRSRLAELGKIPQICHQLNKGLGSASLWDKLRKTCHAILRIRMELNTLNLSSSELIREIKDQLQSKNEGKITLQPGVDAHLDELRERSANLPSLLERVASELKGQPAFHSVTRQVEFKSLSCGLVFGIHVVYFPQIGYLIVVPRGDTIGTEYDATLEHQFASEETVYLKNNLMADMDQNLGDVSSFIVDREIELLDGLHAVLDDSITDLLAAHTALCQLDCLMAFARAATLYELRRPTLVEEQVIKLKGSRHALKALSDESFVPNDLELRGGRGVAHDRDEARARPIEARDGSHEDRESPLSIETASLPPSQASASAGDKFSVMVLTGAFLSQCGCFVPATYAELGVFDKILTRMKQDESLSSEGSSFTRELGRLHRAMSMATEKSLVILDEVGRECRSDDGAGLFIATIYDFLQRGSKCPIVISATHHLRAIERHFPADLPIERAHMQTILLPTLVEAFKSLTYLYRLRPGFAGASHACHCARLCGVPGSVVELAEHICRVGLRAWHKSEADQDEAIVRRLLQLDLGNDEDEQQQQPAMEDNEAIRLLELVLRPEEGAGSTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQM2</accession>
    <name>W3VQM2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQM2"/>
    <dbReference type="HOGENOM" id="CLU_085801_0_0_1"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25405" checksum="C9D8261B5CE4768D" modified="2014-03-19" version="1">MALPPSLQALSIGSLTAPNTLELFVDYLCPFSAKQIKGVHDYLLPLVVGDSAQYKDQVRIVVRPYPQPWHSSSTLLHESALAVAKIALTDPATTSKPDRNAFWLYSLELMKEQGRFFDGPARGKAPDQIRGELATLAIETVGEAPKKRKQDAIHRDLQGTPLGQSIKNLIRVEKEGNGGSAVVPELKYCVKLGRQNGIHVTPTCLWNGLVEGSISSSFDEAAWKEFLAKQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQT8</accession>
    <name>W3VQT8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02139</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_1_3_1"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="839"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1136"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="143"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="296"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="508"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1041"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="545"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1073"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1674" mass="184044" checksum="299A8790066E443D" modified="2014-03-19" version="1">MGKKRPTLKGTVQRGYATTSTPKKVQDPPPAAAKKPAASAAKAASAAAADYEKANDQSLADNLSGSNTPADDGKRTETDFYDPEKEEEQALQNLVEKLQDRVEKEVSRQHKAIEYDRRFAKTLPNFEMEPELRDQVLQIAAELHKPSSSSKARVEGDATGDASTGSVNAVDSASTPASTASGTTTVSGSATPVSVASSHTSLAMATLTKDLQKVSVGNASSSSSTASSSNAWAESQDKVMTRALTTYQLLLKLGFTSAQAEDALANAAAPDVEECLSHLYQSLDEESLEDAIRAGEGKAAKKRRGKDTTGAADDIADDGEDEEYDDSRPPLDAGYEFHRSEALGKNDFARSEQAPSGKIVPGAALSSAATSVPTPAASAKPATAAITAKVDPEKLAALKKACERLVLQLSDDLESDQIDTLEKPTATWSLLRAMQIRIDQEKSKWKKELGKDGDVHMKQEEARLERVLGRTKDFMRECERGAYFDQKTATDGFRQVLRQREEIEKQLKAAEEQEEQKRQQRRREIEAAAGLESSSPTEDVAAESGADKPKAPEVANEKDSEKKPDSQDEDKQKDDAKSEAGSDDEGGFFGDLLNEGPVEDKDADTGFIITMRDLPPRAKSGGGGKTPRVMLSDALKRADAYSTYKFTAIPSGGRLHRSKLTIRWNGGKVVPNKNPITSGSPTYVDEYTLTTVGCATQLQADDFVATVALFCIDRDKSVQRALPPGYREWWEELTALQKDERDRKSRTRFQRVRDVVRVRMDEATAAKKAKAKLPVNGNTAATEQTELGELSSASAPQPSETRAKEIADYFSNRVASPSYQKMLPGRQSLPIANHRQEILDLVENNQIFVLSGETGCGKSTQVPAYILEHCMSQGRNCKIYVTEPRRISAISLAERVSEELGEPRKSVGSNDSLVGYAIRLESNVGKNARLVYATTGIVLRMLEGTAFNEITHVIIDEVHERSIESDFLLIILKTLISHRKDLKVILMSATVDAERISKYCGGCPTIAVPGRTFPVNVHYLEDAVEMSDYIIEDDSPYAFRPKRGYRQGDGSARKQNAPGNKSKLQLLAQAPTPEEEDDPALLDDDDEDPEGRGSSTGGLGKAYRSKTIDTLGRMNEYVINHDLIIKILERVCLEKDLEPYSAATLIFMPGLAEIRKCHDMLVDHPTFGGPGFQLFPLHSTISSENQGAVFNVPPAGVRKIVIATNIAETGITIPDITCVIDSGKHREMRYDEKRQISRLVECFIARSNAKQRRGRAGRVQEGICFHLFTKYRHDSYLDEHPLPEMLRLSLQDLALKLKIMKIKIGDSIEHALSQALDPPSAANVQRAIAALVEVKALTSGEEITHLGRHLSKMPLDVHMGKFLLVATLFKCLDPALTIAAALNSKSPFMTPFGKELEADRAKQSFKLGDSDFLTIANAFNGFRRSTVQNHHRTFCSRSFLSIQNLLQIEELRQQYFSYLIDAGFVSVDDGFRQELNRLRYRSGGANYGKPKFMVIPAELDVNSSSLSMIHATLAAGLYPKLLHIDAKTFQLKTIGNSQPTSIHPSSVNFRVKMSELVRGASSYMLYYTMMQSKKLYAWETGLMDDKAVYMLCGDGEFRLASNSLYIDRQRVRIASADPKTLVALKTLREGLGRLMKASFRNPGKEWTEAQQKLFELACKVLGVGANDKDLALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQV0</accession>
    <name>W3VQV0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02931</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQV0"/>
    <dbReference type="HOGENOM" id="CLU_085469_0_0_1"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="242" mass="26480" checksum="2E0FF3C3DCB68E65" modified="2014-03-19" version="1">MATHRPRSNKPATNGASASSKRSWVLLSALLVGFCAIVAALDSIRSSFYIFDHREVYKIASGAVAKHPGNATAIFDDILDNLRADPKTAPYINKNHFSIESEWMFNNAGGAMGSMYIIHASITEYLIFFGTPVGTEGHTGRHTADDYFNILTGNQYAFPAGALKAEHYPAGSVHHLRRGTVKQYMMPEDGCWALELAQGWIPPMLPFGLADVLSSTLDLPTFGITVWITAREMIGNLLIGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR09</accession>
    <name>W3VR09_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR09"/>
    <dbReference type="HOGENOM" id="CLU_2672117_0_0_1"/>
    <dbReference type="OrthoDB" id="2554764at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="75" mass="7820" checksum="F5425D0644430A36" modified="2014-03-19" version="1">MSSADTASAKKAAGQLQKDQGQLQQSAELHQSGQTDLDRGQGMQNADNETGASGFSAVAGAKDVVKDKLEDRKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR36</accession>
    <name>W3VR36_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR36"/>
    <dbReference type="HOGENOM" id="CLU_1142978_0_0_1"/>
    <dbReference type="OrthoDB" id="10566273at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="243" mass="26967" checksum="80FA736E1CD3B7D2" modified="2014-03-19" version="1">MSNATCQVGGIQAGRGRAADAAKCGRQRSRAAATTATTAMETERDHLEPSASQASPWLRSARSSRLRLAVRRRLVRRWLQARFKLTKADVFAHGCRKGPHRDRRAWVQIRLLTAATPVSNAERPTAGAGLQAIRAWHAPRAQPKLSARASFNFRPFGPQKDRFDQASSDQASSFLVPGPRYTAGRAIEAHSQNHRSRTRLWQHSLYTAQRALSSLETLDPEVTSQHSHKAGAGGDFDRRNMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRB2</accession>
    <name>W3VRB2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydantoinase B/oxoprolinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRB2"/>
    <dbReference type="HOGENOM" id="CLU_020413_0_0_1"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="639" mass="68892" checksum="49A01C178BDBA3F2" modified="2014-03-19" version="1">MAAKSETKQQDAGPDPILLSLFANRFMSVAESMGKSLQQTSISTNIKERLDFSCALFSPDGSLVANAPHLPVHLGSMSFAVKFQVDYLASIGEKMKRGDVIMANMPVAGGSHLPDITCITPCHAADSDEIIFFCASRGHHADIGGITAGSMPPTSKTLFEEGARIKSFKIVSEGNFDRKGLERYMLEEPAQYPGCSGTRCFRDVESDLQAQIAANQKGINLIHSLVAEWGLDMVQRYMEYIRTNAEMAVRSLLKDVAKRMGTNRLHALEHMDDGTPIELNVDINADEGSAVFDFEGTGPEVAANFNCPRSVVSSAIIYCLRSMVSSEIPLNQGCLTPIDIRIPKGSLLDPSETAAVVGGNVLTSQRITDVVLKAFNAAAASQGDTNNLTFGLGGKDKEGNHVEGFGYYETIAGGSGAGPYWHGTSGVHTHMTNTRITDPEIMERRYPVVLREFSLRDGSGGEGRFRGGDGVVRDIEFLSPGIQVSILSERRVFAPYGLEGGESAKKGLNVWVKQRRQADGDLREGEEEGQAPARVINLSGKNTTPMGRGDRIIINTPGGGGWGRRDAEQQDGEERTPINERNASGRMAPLLNDDNSPSGVIAASQVKEDARDVHSVRAPHHTTRTKGSVAEWSAIQLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRC7</accession>
    <name>W3VRC7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor 70 region 4 type 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRC7"/>
    <dbReference type="HOGENOM" id="CLU_1300174_0_0_1"/>
    <dbReference type="OrthoDB" id="2546230at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="Sigma3 and sigma4 domains of RNA polymerase sigma factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase sigma factor 70 region 4 type 2" evidence="2">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="212" mass="22741" checksum="72A63BD4F6A72DE4" modified="2014-03-19" version="1">MSTYSAASSYTTGSTGAPSESASTASSAWSEYEYPSSETSETETEIIELDSASDTDTTITIDDSESCYSRAHSVDSSVMLLATVRGTTPAVSIDGDDKEHKVKAEAKPKVRRAGALRKLSESEQTQIVMLREKGWTLRAIAEVLDCSVNTVNSFCFRRRQKMNKLIATLPGAGGASNAQGAMSGTTRGRRAGVKNERDVGIGGYRFIKKDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRD0</accession>
    <name>W3VRD0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRD0"/>
    <dbReference type="HOGENOM" id="CLU_025272_1_0_1"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="7">
        <location>
            <begin position="352"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="353"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="399"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="448"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="564" mass="61776" checksum="4701050C379C2D6C" modified="2014-03-19" version="1">MSKRPSSPSLDAKASSAATTSSPIGQRQRTGADASAQLNRIKDADGDDEMGEFEDQFEDEFDEEDADAVLAARDSDDDDDDDDAETMEVDGVKVDGKIQRPEDDEADAAQEPEAQVYIPGVTKLEDGQTLEADQSAYEMLHRLNVTWPCLSFDHLKDHLGNDRQSYPHTSYMVAGTQADTASRNEILVMKASQLHKTQNDDGASDDEEDDENDLDDDAILEYKSIPVVGGINRVRAAPTSTPVSELEPCLDPYPVAAWSEVGDVKIFDVRPLLNSLDRPGTSYDARKVNTPMFTVKAHNGVEGYAMDWAGVVNGGAGGGGKASSLRLLTGDIHSKIFLTTAGNAGFTTNPTPFTSHTSSVEDLQWSPKEPTVFASCSADRSVRVWDVRVKNRRSVISVEGAHAQDVNVISWNRGTDYLLVSGGDEGALKVWDLRHFKPNSTPSPVAHFEWHKAPISSVEWHPTEDSIFAAAGRDDQVTLWDLSVEQDDDETQQDGLRDVTLWDLSVEQDDDETQQDGLRDVPPQLLFCHHGLTDCKELHWHPQIPGALATTALDGFNILKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRK3</accession>
    <name>W3VRK3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRK3"/>
    <dbReference type="HOGENOM" id="CLU_797332_0_0_1"/>
    <dbReference type="OrthoDB" id="2548576at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="330" mass="35084" checksum="1381A83B86D248EA" modified="2014-03-19" version="1">MDPASSSSLPSSASCTPRSQLTSDSSQTSQSMSDARSSSSRKRAPQPARSRLSRPFRSPVKKDNPTEPSSPAPTASTSKTMLPCNQSQESSRSIASSSVAIRKQRQALEARLLLLQQANKCLREDLLSTLPKEIARWREAGQLAAQDLWKITGADGGDWSSLAGASTREDHALEPSPPPSPNALKRKARDSPEPSNLLLLRRNRIGSPGAEEQAAALRTLADESGSAQGIDSQGADSEISLPDLSELLRRSQSAIGARTGTRQHASPLGESDRTWSAPAASSASGALPERGSGMESKWNIGTMLDMLGADKSTLGWNVEEEQFADSHNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRZ7</accession>
    <name>W3VRZ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRZ7"/>
    <dbReference type="HOGENOM" id="CLU_600090_0_0_1"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="456" mass="49965" checksum="683F159AB744B4A9" modified="2014-03-19" version="1">MDAPLPDYYRTLGVEARASASEIKEAYKRRSLKTHPDRFPNATPAERQRYTQKFQTLADAYYVLSDTQRRREYDELRSSRPSSNSYFGSGVDSDDDEAASEYSEKEQSHSANFFQSFFPGAFKQEEGQEEQSYNASDDARRGSSQPAADGVFANVFEELLRPEVHRVAPVWKYVGGASGTALGFIVGNIPGALAGAFAGSQLGRIRDAKGKSVAEVFMGLGASQRAEAKRTRANAEARHSTRIFPGYDKRLPAAAQAVVEQALLDNDLANADADDARWRQLYDELDTLIHRSREMPAPETPKTHTGSFLDNDDEGQYEWGSDSDDDCEAQAVSSHVEDDEARQAQEAYARSILPKGDLATAVHRAVSESLHSNKTKGKGKGTGKGKGKATGSGGESGFDWDPSSLAALTMLCEEIALSQAAFSARRSMFAKQASKGSKKKQRRLEQQSQAQPEQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS47</accession>
    <name>W3VS47_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxisomal membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS47"/>
    <dbReference type="HOGENOM" id="CLU_276824_0_0_1"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1148" mass="120865" checksum="C28A0EDAA81CA2AF" modified="2014-03-19" version="1">MSLEKKLTQVALNPAYHDFFTVVKGFRNGIVYGAKIRFPHALVMTFLFGRGTPREKLAFILRATKSHALNLGTFTPLYKFLTIALRRIYEATGGKGAVPQWHSLVAGLIGGYYVFGERTPVNEQIVLYTSSRIIASFLPRAQTPADWPAGKPKPTDKSWFAAYATITWGVVMWLHEYRRQTIQTGMVNSMDYLYHNAGKWDSIVDPAGADQSRTICSLGRWGSCEIDAWFKASLGETATTARDDVLATTQIRRKHRHRHAHLASTVGLFGSCRRGARVGMKADSRSKAECRSGAGQVVATKLADRHGAERVTAAKWKRKSSVEQGEKKTPAAECEERGGSKEASQRAGVDEQHPENNTPHGPPPTPAAMCSAVPKCTGRVRRVFVSDCRESNNKGPQRAQNKRRLLLAASTGFKLRVGLAGFEDSQGTATRRRVRGIRKKLGGRRGAGAAGIPRAAGQDEARLTRLNPSIHRFIDTTAITMSAINQNAPRMRRHKRRILDDGSELAHAVRAFVDDQVDDNALFARQADGANGIGPGRGANAPPMGPGFGGSGDDSTSSTDSSNATPTTTRGSNGNGNGNSRPTPTATSTSLSRNLFPTTTSSSSSSNFLDGILGGLLDSSSSTTSSSSSTSTSSSTRSTSTSSSTRSTSSSSSTSSVSVHSDSQTATQQQQQPQTTSESNDDDTSTRIDFSSVGLPTFVVPDHMSSSFLSSTSLVPITATAVVTSTPTASIASATASASPKSSSSSAGPIIGIVAGALVGVVVLSGLVGFLFKKYKSKEDPYEANPFDRDAFQRHSAMIPDHFDSDDGHAGAGGMSPEMSEHYQYNNYAPQYESGISAGAAGAMGAMAAHNEGGPRPPTMFAKHAAGVQQNAPQVGGYYKDGDFANQMPAMPPHSDYHAPPTAAFANHHAAEHYLEEPGFGQQRSVSPAPQLPPLAAFGGDPYSIAGVGRGQQQNVANPYAHLDRSHAGMGGFVPGAVVPGHAGSASVSSGGDSADRHASISAAEALAAGLAHQSSLNRAASPHHAASHDTAGRPSTSEGRSGTPDIPNVQQTYALPGDVAGAAGSHRISAGSQDMLSNAATSPVGAMRNPFDNPAPHHAPQHHYTDPSQQLQVRNLVPANAGLSAGQRPVSTASSFADPEDAYGGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS65</accession>
    <name>W3VS65_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS65"/>
    <dbReference type="HOGENOM" id="CLU_464696_0_0_1"/>
    <dbReference type="OrthoDB" id="10433556at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833237" evidence="2">
        <location>
            <begin position="28"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="587" mass="64508" checksum="D419F787C53EB22F" modified="2014-03-19" version="1">MHFPNFIKLSTCLGVIALAMLQNKAWGANAVPVVQPDPMDRSTVTAWSGQIMGKMNALGSPPSRMDVATVPLGQMRSLADRVRNELRERSGDRHLLYLGPSSRGHMYAFPLTRTEHGLRLVTGPPDRYSQMALISVSPRGHGERSIYLHDIVGAWIPNKNIMYQNLMGANAYHYSSASMVRRADLIVASGRLKSMSFRPVEVDIPFMQPTPPVLIWLPLPHLDSLANACVYCGIVVPNSLSYLESGQDRKLEALSHASHLQSFPTPGFMKATSSDLRLTIFEQLSPDQRLNRSRWLIMRIKSARLLLAMPRLLSLVLVATYLLNEPVLAAGDDEKGKGLEPSSFIFESSGPARLSGASSVPRRRSRLSAMGSPSTPGSSSNPGFVSHPGSSSNPGSSSAPGMSSDPLVVSDPAQAAPPPTIPEIEIVPPSVHFPPFINIVPIPEHEPWHMYRQFRYRLAQLDIDHRSLALLNPRADFVGDHRTMLRDQLQAQVDLKHALVLTPTIDHGGRVYAVPIFRDSVKEALIGSKSHQNVGWALIGIWPGRQTSVAWFGYALLDVRGRASLIQKLQDSVKVKVLADLLRPIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSD3</accession>
    <name>W3VSD3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSD3"/>
    <dbReference type="HOGENOM" id="CLU_2211091_0_0_1"/>
    <dbReference type="OrthoDB" id="10300140at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="107" mass="11902" checksum="694C73EFB15E95F0" modified="2014-03-19" version="1">MDKVVVEVMDKGDDFDVDLSALLERLEKYDWPERLGASIKASLDDLMAAPQLDSPTLLAKLEELQKTCPDLQISVQETHKDGDGEQQSESSQLCEDTSEESQQGQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSH0</accession>
    <name>W3VSH0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="8">1.3.3.4</ecNumber>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PaG_00966</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="8"/>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSH0"/>
    <dbReference type="HOGENOM" id="CLU_278614_0_0_1"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000276">
        <property type="entry name" value="Protoporphyrinogen oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amine oxidase" evidence="21">
        <location>
            <begin position="44"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="950"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1104"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETS64504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1128" mass="121875" checksum="A8E4112FF7C57FE0" modified="2014-03-19" version="1">MATGLRGAWQAAIAPPRRSLATSSALLAAAASDKKRIAVLGGGIAGLTSAYRLAQQLPQDRYDVVLLEQQSRLGGWIQSERISLPSDASTSPSPTALVEMGPRSIRPAGYSGLVMLQLVQSLGLLERLLRVPKTAPSAQNRFLYFPDKLAKLPSSIPSLLSALFKLPFLRAIVPSIIREPRVPSRFLRPRSESQAEKKRLQQRELLDDESVDSFVSRRFGKGVAENLVSAVIHGIYAGDTRKLSVRAVMPFLWEAERVHGSVLRSMLPAKRNKRHRPLPEPEAAAKAAKEDRLKHVEQQLGKELVDSFKGISVYSFPEGVQEIVAALEQRLAALPNVQLRTNEGVRAINIDESGKLRITTASGESIEADRVISSVPSSKLADILPSAELPHLKHNPAANVAVVNVVISPSAAAEAGRALVPVQGFGYLIPRTTPGNDDGILGVVFDSDAVPDQDAAEPSRRPVKLTVMMGGAHWAGLEQLPDEDEVKARAVRALSRQLDIDAQLLRDASKVTIKPTMQRECIPWYLVGHPVRMAQLHKALAGNAHLASRLTLVGASYTGVSLNDCVAYATEAVEQIVAAELHGDDQTVTGLASFAIPPPAAPAAASAVRRVAQRGTAGLPSQGLVGPASSPTMQFGRALHTRRAFSTCRALHEQGQPTAPAPTTVVGEKANKSLREILLDSVRASGPMTVSTYMRTCLLDPMQGYYASANSPATEREVLGSRGDFITSPEISQVFGELLAIFYLARWQAVGSPASTRLVELGPGKGTLLADMLRTFASFRPFMATLKRIQLVETSAGLMELQLSAIRDALAAAGKRVVDAEEEVGEDGVVVEWFPSVDMVPIVAEEFSIVTAHEFFDALPTHIFEKHVDGKFREVLVGIKPKSSITVLRPGQEMEAPKEELGFVLSPTPTPWAQMLVQNNPRFAALQPGQRVEVSPESWAVARRVGELVAGRPASPPRNPAATEEQNQQYDEAEQQRLGANSAGGVGFIIDYGGDQAYGASFRAFKQHALVDVFQSPGAVDLTVNVDFLHLKSALHTTNARYAGPIDQADLLVGMGLQMRVDRLLQGKDDSARKRIIDAANRLIDETGMGVQYKALAVAAAPVPPADPRTQVRDKKQDPDMYPFEFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSI6</accession>
    <name>W3VSI6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00989</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSI6"/>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000107">
        <property type="entry name" value="Related to translation elongation factor HBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="119"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="563" mass="58611" checksum="2A6319D6E8D7D704" modified="2014-03-19" version="1">MTKLTQHSAPIILHSSSTAAKKAAASASTPASGTSTPLHRKAAVGQAAKAAASGGAKQGGTSVSQLRNEIESLGIHAGSKAASSAGSASSAIQSAVTTPVGIAHERIIDEYRRREREGKAELSLVVVGHVDAGKSTLMGRMLLELGSLSQREYSSNERASQKIGKGSFAYAWALDSSEEERERGVTIDVAQDHFSTTHRTFTLLDAPGHRDFIPNMISGAAQADSALLVVDSILGAFEAGFGPNGQTREHALLVRSLGVQQLVVVVNKLDAVGYSQERYNEIVTKVKPFLTSCGFDAAKLRFVPCGGSVGENLAVREEGGDLSKWYDGPTLVEVLDKLEPPARLLDGPLRLPVTNVFKGQTAIASGVGVSGRVVSGIVQIGDRLRPVPGDESGMVRAIEVDSEAVPWAVAGANATVYLSGIDQIQIAVGAVLCSSSQPIALCDSFTAQVLVFEPTYPLVAGTSIELFHHSANIPATLTELVAILDKTTGAVAKAKPRVLTKGSTAIVRVAVKAGGAAGQSSGIPIEDAKSNKEMARVLMRMNGETVAAGIVMEAHSASARVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSK0</accession>
    <name>W3VSK0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSK0"/>
    <dbReference type="HOGENOM" id="CLU_900538_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="309" mass="33477" checksum="75865A8B39412A8E" modified="2014-03-19" version="1">MAGLDAMAGPSFAARWKEDGERATVTVKPCRLSAASREQRQRPLVVCLSITNAGTRGILWLLICRFISSLCTRHSNFLYIQNLASPPVDRSSEAASSSPSGQAVDKNRNPPARLETPTGLKGVQGCCPLRPIFGPGRVPLERRPNRPRSLRFLTNKRRGPLPLLQVRKTLAHAPNDTVRERELVHLGTADASALQIHAALPPSESPLIFLFLLVRVASTLLHLPLLLPLPRDFASPAAIDRIQAVSLRNVGSAVAVYRQSLTSSLPLPRVLHPFCIAALGSSELSGPDHLFPLLRGSVDLDSTLSPHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSS7</accession>
    <name>W3VSS7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02167</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSS7"/>
    <dbReference type="HOGENOM" id="CLU_022045_1_0_1"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="617"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="619"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="697" mass="75779" checksum="6BA823E749754FB8" modified="2014-03-19" version="1">MAAEVIPPALAGPTEHGTSTKEATTTTLGLLKSEWELLTLSTAVKLLLFPTYHSTDFEVHRNWLAITRSLPMRDWYFEATSQWTLDYPPFFAYFSWILAQPAALVDPLIVSLHEGLEYSAWSCKAYMRATVIATELVLAAALLAHARIGTQRTMKIGFTDSTTAGPSTSYILAASLLMHPGLIIIDHIHFQYNGFLFGVLAWSLWAAREDHPLLCAFLFSSLLNLKHIYVYVAPPFLVFLLRSYVVPVGTRASDVGRCVERLITVGVVTLIPFVLSLAPLALDGLRHEAGPLGVLAQMVKRLFPFSRGLIHAYWAPNAWALWTFADRVLVKLLPRVPALRMFVPAGMLARFDASAGSGFASASRGLVENIAFGIMPDISPSMCFALTLTCMCVYMVKLWQTPTYRSFLAAVSLCGFASFLFGWHVHEKAIMLPLIPYTLLAAVDYAHLRTFVLLSAAGIVSLFPLLFTPQEAPIKMAYSIVWALLVLGPLQKRVFRPVQSNLGLVVHRLESLYLWGFVALQAYVSIVHPMIFAQAGHSVVLPVQPVLASPANATHASAAAAHLASDVIPLPPATAIADSAAVQIDADPPLPVATPDSNADGADEAVAVDTAEFDVAPPTSDSISRRLLSTPTAPDTPSTGSIQDQPEATATTSKVQELTPSESSMEFLPLMMVSVYCSLGVIWAWMRASAVYLLSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSV3</accession>
    <name>W3VSV3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_02184</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSV3"/>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_1"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="16">
        <location>
            <begin position="127"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="14">
        <location>
            <begin position="232"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="17">
        <location>
            <begin position="464"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS63862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="614" mass="67582" checksum="8AF964F75416C84D" modified="2014-03-19" version="1">MASQKKDLPKIRDEEREQRFGTVFGVSGPVVVAENMIGSSMYELVRVGHDELVGEIIRIDADKVTIQVYEETSGVSVGDPVLSTGKPLSVELGPGLMENIYDGIQRPLESIMKKSGGIYIPRGINTQALDRQLSWDFTPGQLKVGDHISGGDIFGSVYENSLLKDHKLMLGPRAMGTITHIAEKGSYSVDDVVLETEFQGKKQKHTMLQIWPVRAPRPVAEKLQANNPLLTGQRILDSLFPCIQGGTTAIPGAFGCGKTVISQALSKYSNSDIITYVGCGERGNEMAEVLAEFPELTLMRDGEEFPIMKRTTLVANTSNMPVAAREASIYTGITLSEYFRDQGYNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGAKLASFYERAGRVACLGSPEREGSISIVGAVSPPGGDFSDPVTSATLGIVGAFWGLDKKLAQRKHFPSVNWDVSYSNYINALEPYYEKNKPGFIQLRTTAKNMLQKDTDLAEIVQLVGKSALGEGDKVTLDVAKIMKDDYLQQNGISEYDAYCPFYKTTGMLKNMVDFHDRAQAAIANNPDMTWAKVKEHCSDVIYRLTQQKFESPKDGEEAITKKFDKLNQDITEAFRTLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT45</accession>
    <name>W3VT45_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT45"/>
    <dbReference type="HOGENOM" id="CLU_1116150_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="249" mass="27080" checksum="EADB0012DEB0DA91" modified="2014-03-19" version="1">MHPLPRQASLSLLSYSTPTPFSLGLRRGLGGLGSPGVWLQGLTRLLSTVVGPMLAAPVEGPATALRRPCDGARSARYNSRRLAPQPRRCSSPFLPSPAGWPHCRRTPAKPDRTAAQPVSLCRPSCFMRNPISPNPHRFRLGRCHAASEPSSKRTFKLPHRTPFLPPVLDQHSWPFAASILAPTIIFRPRHIHLLSSIPPHLRIFSSCQSLVVPGDHSASTSHGSLDLRAAHRPACIPAKECGSYVPIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTN8</accession>
    <name>W3VTN8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTN8"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="248" mass="26466" checksum="28811F5204687ACD" modified="2014-03-19" version="1">MSDTAKVVLISGGNTGIGAATAELLASQGWRVIISGRNADSAKRVTDSITAKGGQVRFLQADIGRENEVIRLHKDALDIWGRLDAAVNNAGISTDSAMFHELDTKHFRDMLEVNVLGLFWSMKEQLKHFSKSGKGHIVNLSSIAGMHGVPFTGSYSATKHAVSGMTRSAALDYAKTDIRINAVAPGAIQTDILSDALRRGVYTYESIADMFPTKKLGVALDIAQAISFLLNSNYATGSFVSVDGGYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTQ7</accession>
    <name>W3VTQ7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTQ7"/>
    <dbReference type="HOGENOM" id="CLU_457175_0_0_1"/>
    <dbReference type="OrthoDB" id="2547097at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="619" mass="67700" checksum="8CD011EBD0BE90CF" modified="2014-03-19" version="1">MAAGSRKRRRANGRLASPPLGPSPLLTRNLQLLPVGLTRLPSDVHFVSQLRNDIGELLSAFAEALLLFVVQSDGSTGSRQDNGGQGDRPVASAFSIFASLWRRKGWHYAQFAFGDHTDSKQAFGEAICRALLEHLSPHVDRRNGFMAQAQNGEEAVTFTDLRQLFEAYGVPLALYVFWSTQMYCDSGTGVKHCRPAMERIAIEQDYYDWLLELPQAVLKHLEAEPRTQRDAHIITADLVEVLCRLTGSTPDDDPGDGAAAAGSDGARGQGAKTRRTARKTSDEPKRRRPEARKAESRSVYDRADTVFDIVSASRFYTRMPRTWPSVRVVSTLEANKEFGRLGQIVRIQPTSTRDAGSPDQVPTESSRSGVTDAERQDVSEEARKVVAGLSRGDVVRLKARQRLALASLDLSKLAEQTHSGESSSNTAMRQIDASELLAETAEGSGDSPSRQRARYEIQTPAWISSAKYTAKMKPWLEQASTPMQQSLERVASSSQKYAEARSRIMPSSQTHNADRAGEAEQASVDQDQPAVQTDFGQYVLQSFRAERQGRGSATAANEASQDATGGAESSASTAGVTVDDTGSLSLESLYRLAAERTKTEAVARGETLKSLRARTNRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTT7</accession>
    <name>W3VTT7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002027_0_0_1"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="947"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1334" mass="143037" checksum="0F5D4D39EB4F3690" modified="2014-03-19" version="1">MADQQAGQEPDEFGALPGGVSNLRSRFEQLSKSESSRPSHTPHTSSNNIRHKDLNATHTFGLAEKKLSLAQNAGNGPVRPPKPKKAPSPVSDDPSASLKPAHAGPSTISVADLAALSVSAGSSTSSVDQIRPASIKDRQISHTRVPSGQAKQLAASACKFGEPDRSLRASKPSLPRESSSSMSASTTASATASASASDAEGPSKPRLPPPRPPKPSTSSHGVQILGDSDLERLAHMGSSSRVTSIANLFGSHSAAKPKAAGTNATLSPGRISTGGHFLKYSRSNEQLSPTAPAAESQSDPFKKLPPTVPPRPLKTDASADSLSALPGSIASVLLDVDSGSFPAVPTKPVATTVTRASPPPLPARESVPIDNVEFRRRSLSASKSTGSLPVLSDMFPAEELDTPPSPARRPAGTDAATMTQDGSTFLPPPQRTTAPPASNPGPHRAHTVSARTKPIPVPSLAARQTKHARSMTPSGTDFVAAPILPPPVRNANATSAAAATKSFGSSGFARRQPGSDSSEEEDDGDFASSLSPSSSFKATAGLRRSHAAADMTPGGLPDTSHANRRAPKFNPDCGTSAKQGFQCFAVCGHTVVTGSGDKVKVYRVGESASGVGEKLCTVGEHLSKEVKLTALEFRPPNHGIAPVPAIGRRSHGETADEGRYLWCGTKDGHIWELDIAEAQVVHSRQNVHSDPIQLLKRVGNKMFSLDEGGKISIWLPSADPDPAIAGLRLSNQPITQRIAMEKGSHACIVGQQLWVAAGPSAQRNAKDYAGSKGPRIRIYNPFADDKPFNALSKAAAIAPEMAEGVGVVTGGAVIPSRPDYVYFGHDSGHVSIWSRQTYECVGVRKLGPHGITALAGVLKYLWVATRAGTISVFDTDTAPWRAIKIWTAHKDPITAIKVDEHGIQKVGRLQVASGGLDAAVHLWDGTLSFDWIQAEQSKREHEFSTYRSIKTLQVTFNMDAASPADLETSAENMEVFGSMLRNACQIGSDSLAADRPPDIIVFGFQELIDLESKKLTAKSLLLGGGKKKANDLGDRVSRQYRAWYDKLIQIVRYAMPPTCGYLLVQSESLVGLFTCVFVKQTEFKNIRELAISTVKTGMGGRYGNKGAVIARMVVQDTSIVFVNSHLAAGQKHVKQRNADVADILEYPTVFQDAHADPAAYVGGGDGSMILDHELCFWAGDLNYRIDHSRETVLSAIGARKITPLLEQDQLRKELKQNPAFRLKDFSEAPISFLPTYKYDRGSYEWDTSEKNRIPAWCDRILFKSHHPERIRCLEYRRWEATISDHRPVTAIFEAKIKAADHSKRQQVLDELKSAWSSLEEKLLANAVVFYSDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTX3</accession>
    <name>W3VTX3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTX3"/>
    <dbReference type="HOGENOM" id="CLU_024654_0_0_1"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="202"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="589" mass="64099" checksum="B4D8841352BA4F3F" modified="2014-03-19" version="1">MPRIPVRVEPYSSPSRQHRHYKNKRDQVLRALGKAAYINGSHFAIMWVSARGDVETYASEALQSRLDDWFVAGGIAEEAKELVKVAGGKPSSKVFDDSDEDEENEDSNEDPFLDSQVGAKRKVLAPLNTAAANQHFLRSRSWNDEAPKSAPLFPTSSAGFVDEPPRTSTPIMSASSRMLARNSISGGVGTAAGTPTVDISLADEAARTAFLELRFGQLQQGVCKTVAKAWIKIIEPKKQTRCPYNKGEQGKPDWWPAGVRHKEPDHLMKPERHALLLTILRSPKVQVARLQLATAEVVALIKADKVSLLMDVYRIAREEEKIREKGADKDTPLTVGVSTLDGWCSSDSAPTTHGRQIARSATPEVAERKKRPAPAMDKGKGGGGKRRSIAAPTSGEIRPRHLAPQEAGVVGLGLMARSNSLSAMPTPAGSAETSPWPASYATFAHAHGLVTPLTASATLDPAFSAMAHPPPPEGTFYYPPPPAQAFYESIPPHAIPPHQQQQQQQPDGNAGLGFEPNALGLEGWNFALDMSADLSNNTAWSGDNSFSIESIPAPKTPEGELRINMPHNHQHKPEFWMQNQWNPSQHQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU71</accession>
    <name>W3VU71_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU71"/>
    <dbReference type="HOGENOM" id="CLU_518729_0_0_1"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="56806" checksum="4218290520CF17F2" modified="2014-03-19" version="1">MTHARSLSLHERYSVARRSVESPSIVAAAALVHLDASDQAFEQLQAHLARRIDSALQLYPLLGYCVQSPRSRKPTWAPMAKAPTSSDILRLGAAVDGVAGDKIMAQALLGVQLSLPETSALETGPLWQVQLHRVQDSQGALVVLATDHAINDGRGTLNLFRFLLQATEPPNAPAAEMPKASDVVFDFKPSVRYMLGMVWKELLLPKLPLPSKLATKLRGPVSWPEAPVSAQTNEVGRCPKGCAPALDTMLVSAPQLITNLKQLAHAHNPAEGKPATLHAVLHTLALAALYAAIARPLEAHALGEFDMVFRTGTPISLRTDAPGLPEVSGNYVSSYTCKTTLRGGVPFWTEANRFSAKLASPRGRNKAKHHMGMLAYIPDFEGDPEAYANGWEKFFGSRMESSTPFDAAFTVSNLGMIDLSTLHGQGWKVTDASWAQSHTPQGEAFGIDVLGYNTSGQQCLSIGLSSRPSAFQDKALHDRFVSYLNHLVRAFASTPEHEKQQDLDLDSNPSFADIALLLYSALPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU93</accession>
    <name>W3VU93_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU93"/>
    <dbReference type="HOGENOM" id="CLU_022379_1_0_1"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="162"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="580" mass="65919" checksum="528E829726C7AB80" modified="2014-03-19" version="1">MAPTTQPKAAAKVARPAARYRPGKAPVGAAGSLDDFSDSDNDEHADDHDSRHTAAPTSVSISDLSSGTAALQSSAQRRMAGIVIADPSSSPKKISVRLNAAAEPTGAQEQDDSSEYETDTSEDDSEPAQARPVFRKPDAPSQSAQKDESCEYETDSDDEGSGEEAAPPPLAKPIFVPKRARTTIAAGTADAEAAQEDVEAKAEEEAAKRRQEAHDLAAATIKRQLAEKEYQETHATDVDDTDGLDPEAEFEAWRQRELARLQRDREAMDEKRKAQAELDAFRALPESEKERLGRERAKQQAAEKREQRGNPAFLQKYYHKGSFFQDMDILKRDYTEATSSQVDVSKLPKMMQVRNFGAKGRSKWTHLANEDTSKSAMKLDMASACFVCGGAHMKKDCPQRGGAERSGSNRADLGDGVDGSRTWGESAPEAQSERRRSRSPRPERTRREEDGEEQSRSRRDHNHKSSSSHRDREHRELREHRSHHRDRSRERQDERDRDRRSRYRDDDQSRHDTERRERRRDDEADRQRRQRSDHEHREHRHRRERRDESDSQRRSKRHDDQHADDLHRKRSRHTSPPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUS7</accession>
    <name>W3VUS7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00012</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUS7"/>
    <dbReference type="HOGENOM" id="CLU_012163_0_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="309"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS65289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="787" mass="83386" checksum="C4F56A15417BBEA7" modified="2014-03-19" version="1">MAQPTAPNMANPAADAATLTASNYTVDKSQIPRPYKCPLCSRAFYRLEHQTRHIRTHTGEKPHVCTHPGCEKRFSRSDELTRHVRIHANPKKGGAHADDKKAAARKSGSNPSSPHGAAPAIASASSKPGSAHANRSFRWQLGAEEDAEDSDSDRELRHAARPARTGEMSALAMLASDELHELQRAEREGRRSGPHPPHAYHSHYAPDAYTDRYHAHGSTAAAASGHTSASYAYPPPPASSGESTPPGCSHEDCHRKYNDRIASAILARPAQNRYAAECGYSRPSHAGYNGSHPPPSLYRYYQHGSHHGAGGWASTSSSVPSSVEHSPRFSPDDHLHGDDYASESEHAASLHDDAKPPRLPLAPSGPAPLATHSNSHWTPSSSPVLGPLRNMSLLGGNTVPNSPYTSRPGSPVLHSRHAHGLSPPHHHRSHEGPAHQSGLGHHGSHRHRSHPYMESSARSRSHHHLSSLGATPMQPSSSSHAIPSSTSGERSTAVELDSHASGSASTSASTSPAQPSHMPPKLSRSHSFGSRSKGIPSLNSSTSLSAYHLTPAHPPAADAERGSRRTKIEDILDGGMGSLKPHASRSSYPHLVADPSSRTLPPPFPASASHRDGSHHPVPGHHHTHAYNYHPYGDHKKSMRSSSRSAPASRSGSPHGSPTLHPLASLPNALSSRSHSRQSSIGNAFAHPGNGLVSAESSPTSVYSQIPGSASNSPAAGAPSVARSKKGLGGFGMTPIHSAQRDREHNTTLPSLGQALSRETSPISMVLPPPMKRMPSDGAPEVDMSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVK3</accession>
    <name>W3VVK3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVK3"/>
    <dbReference type="HOGENOM" id="CLU_073125_0_1_1"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="215" mass="23653" checksum="D53CE272325D483F" modified="2014-03-19" version="1">MSLPAAAKSYLSLIATRRSTYTLAKEPSILNVDQIHSILSSVLEYSPSSFNCKSPRLVLLLGADHDEYWGTTIPNALTSIMKSHGAGEEAIKAATGRLAMFKPAFGTVVFFESSAVVEEQQKNMPQYKDNFPIWSEHATGIAQTNAWSALTNAGYGANLQHYANLGEQALKEKYNLPSDWKPKAELVFGAKTAEPQPKEYNAEEENKNRLHVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVX6</accession>
    <name>W3VVX6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVX6"/>
    <dbReference type="HOGENOM" id="CLU_953754_0_0_1"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="98"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="273" mass="28705" checksum="DBDFE0A6DC7414B1" modified="2014-03-19" version="1">MAARRIQSPLRDLGRSMRSMRSRSEIPAASACCSSGPSSASRAFASAASSTASSSTTAAPVPSSRPSLRSADSRPSPALGTRITGADVLAHLSGGSSGLLDSNADLALRAVTHESYLNAREGHNRRLAFVGRRTLKLFTTLFLHSRLQSLAPGAARTYINHLLESPSAVDSILSTHRLGDKVGRSLALESVMRWTPAVSDGQMGPRETGLFKTGLFKVRGVAVEAIVGAIYHQNGAMAASSFFHSAVLPELLQDGFPAPVPQELKDGIVADKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW25</accession>
    <name>W3VW25_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0390 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW25"/>
    <dbReference type="HOGENOM" id="CLU_157438_1_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967:SF1">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="94" mass="9854" checksum="17148C9D45E3114A" modified="2014-03-19" version="1">MAQGFKPAKPKKAAASPKSGSKAKSGPKRGPRVIAPKKKAAVQAAKTKQKQTASITARIEQEMVGRASKGGPLTIMKKAADGDADDKKKNQNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWA3</accession>
    <name>W3VWA3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWA3"/>
    <dbReference type="HOGENOM" id="CLU_2528390_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS65061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="84" mass="9285" checksum="088E53190AB22B72" modified="2014-03-19" version="1">MLLAAMLTARRNSTEICDNLPARNSADVGITRDAVRSPHLGQHDLGLATPLGLPKPILDRIKQCVDRVYRSILKAELVVRELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX13</accession>
    <name>W3VX13_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX13"/>
    <dbReference type="HOGENOM" id="CLU_1768896_0_0_1"/>
    <dbReference type="OrthoDB" id="10504245at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS65362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="147" mass="15877" checksum="433D47D2B97D749D" modified="2014-03-19" version="1">MPSSLPKAHVQPSHSATPIARGGVLVVIPRPEHLRTRTRRRSFGPLALTQPFPLSQRQNDEAPTLQLSYEVANSLGLVRALPCINICDRVSPELPKLHPPVAAPHRSAVLLCSDSCYPVEPSTWIQANAFPALPGAASPRLFAPSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VCW7</accession>
    <name>W3VCW7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VCW7"/>
    <dbReference type="HOGENOM" id="CLU_1587214_0_0_1"/>
    <dbReference type="OrthoDB" id="10316218at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833059" evidence="1">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="168" mass="19007" checksum="66EAAE656146AA95" modified="2014-03-19" version="1">MTSSYRLVSVVLLVAWLFCFAAGENLGDAVLSDKDREMLQLSRRSQAIRHNAVGAMMEPATLAANLDVKDFANRAREIAQKRAVFVGTRHQLIWGPKMVGDRHTYFYTVIHPIEPLGADMRLQDKMATILMRYSTQTGRSSVVHVGAIKHDPRVVWDFQPLSRILAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDP3</accession>
    <name>W3VDP3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_06577</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDP3"/>
    <dbReference type="HOGENOM" id="CLU_002360_3_2_1"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="932"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS59650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1005" mass="108265" checksum="8FAD73AD85F90A20" modified="2014-03-19" version="1">MDAAWTKSVHEALTILNVDPSKGLSDDEVEQRRAKYGDNTLPEQPPTPLWELILEQFKDQLVLILLASAVISFVLALLEEDTTLGAALIEPGVIVLILIANATVGVVQERNADKAIDALKEYSPDTATVIRNADTDKVRSELLVPGDILILTVGDKIPADCRLIAINSSSFRVDQAILTGESISVNKSLDPVHDPNAVKQDQTNILFSGTTVANGTALAVVALTGTRTAIGDIHAEISKDDDEKTPLKQKLDDFGELLAKVITVICILVWIVNFRHFNDPSHHGWVRGAMYYFKIAVALAVAAIPEGLAAVITACLALGTKKMAKKNAIVRHLPSVETLGSTNVICSDKTGTLTTNQMSVTHFSVVSPSGSLADYSVSGSTFAPVGDISDADGKIVTGLNQARTAFHALAEVSSICNDSHVHLDDHANYTIVGQPTEAALKVLVEKLGHHDAAVNASVAKLDAHARAGTITNEYGKAHPRLLTFEFSRDRKSMSTLIQRSSATGCLLVKGAPESVVERCDSVLIGKKAQPLDAGLRSQIGDKVLEYGRLGLRTLALAVKEDVPLDVESYRSSSPAEYVQFEQNMTLVGLVGMLDPPRPEVRTAIQRCRQAGIRVIVITGDNKNTAETICRQIGVFDATEPLDGKSFTGREFDALATRDDRLAAVSRPSLFSRVEPSHKSQLVDLLQSQGLVVAMTGDGVNDAPALKKADIGIAMGSGTDVAKLAADMVLADDNFATIEAAVQEGRAIFNNMQSFIRYLISSNIGEVVSIFLTVVLGLPEALIPVQLLWVNLVTDGLPATALGFNPPATSIMREKPRSRNDPLISGWIFTRYLLVGAFVGAATIFGYAWWFVLYTGGPQISYAQLSHFHQCALPAAQAKGGLFEGVDCGIFTAYRQPATIALSVLVVVEMFNALNAISETDSLLTFGPWKNPLLIGAIALSLGLHYAICTVPFLQDWFQVTRLNVDEVKAVVWISAPVIAIEEVCKLITRHFFLNQQKPATKDKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE35</accession>
    <name>W3VE35_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE35"/>
    <dbReference type="HOGENOM" id="CLU_155994_0_0_1"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="106" mass="10750" checksum="BB62324F030795CC" modified="2014-03-19" version="1">MSNTGNTGNTGNKIGDTIKGVLNAGHGAGETIRGTINQTLDSAGEGLRQGSSDTHTARDAPTDGKSADYAGNHSQRDVTQNGADELKRGIDSIAGAFGKDKPHSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE75</accession>
    <name>W3VE75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_06159</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE75"/>
    <dbReference type="HOGENOM" id="CLU_618376_0_0_1"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="89"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="318"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS59849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="442" mass="46381" checksum="9A07BCFC56CD9560" modified="2014-03-19" version="1">MPALPTTPKPSGPDADSSWLLDENLSPGLVQGSMQNLHLADSPLTAPLQSTAATNRASQPRASKPIKSRPSWGSAVVLDAQHSANAISGMRLLAGIQPNDENKPPVSRKPPTSSSSTAGAPARPRFSLFAKPGVPTNLVPKKPHNASTASQHDDDDDDDLTLHGLPDVSALASSSSHAPDASAASAYIPDDDYIRDALLGKPASAAVATGAPTPVESKESQEHAARQLAELRRINDVFEAFETSLRGSAGQINAFARRVRDTDDLLNIYISLLRQTEKTQQLLQDQDWKGTTKDAEAHKESLAIAHRETQRLHAEALAREQEAKRAAQLAAQQAEELQRRQQEEARRAAGPGARGRGGRTVSTGTRGAARGGVARATSSRTASKPSDTQPAATATASTRGRSASASTRGTARPSAIPTRTPSGSAGLGGQYANVKSSGYGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE99</accession>
    <name>W3VE99_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with TRM9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE99"/>
    <dbReference type="HOGENOM" id="CLU_031077_6_0_1"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21089">
        <property type="entry name" value="Trm112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000018">
        <property type="entry name" value="Multifunctional methyltransferase subunit TRM112-like B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00065633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56298" checksum="17BB244492FF0BE3" modified="2014-03-19" version="1">MRLLTHNLLACHAKACQTTSNNFPLILKDVQLELIEAEPNDTFVKGFLPKLDWPALVKTARSLGDTSLPDQGPDASQPLEDEALIKLLHHVLLEIHVVEGQMICPNCQHIYQIRSGIPNMLLAEHEIGNGDAKATQPGVTLERATPPRPSTIASFNPFGRDHSSFPPLCVRIDIRIRTSHLPPRHLRQASTATMASFFSFSSPVDVDVRLDAEDDRKQVEIKMDKAGKEKCPIYFDGESVKGSVSVRVRDGKKLVHEGIKIEFVGSIEMFYDRGNHYEFLSLVQELASPGEMRAAQNFDFEFKNVEKQYESYNGINVKLRYYIRVTISRRLTDVVKERDIWVHSYRMPPDSNNAIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMELSIIRRETTGAAPNQYNESETITKFEIMDGAPVRGETIPIRLFLGGFELTPTFRDVNKKFSTRYYLNLVLIDEENRRYFKQQEITVFRIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEH2</accession>
    <name>W3VEH2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEH2"/>
    <dbReference type="HOGENOM" id="CLU_320341_0_0_1"/>
    <dbReference type="OrthoDB" id="2555027at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="927"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="950"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1120" mass="118963" checksum="8581F16EEB3B92E6" modified="2014-03-19" version="1">MPAANPLRPTAFKRFRSLVTAIHRSLSLAFSPSSAHLLASQPTPFPLPPLQPHPLCTLGSSSLGTSARRTPCSLGGRPVAHTVRSTGFQYLYAFAYPSPPLAAQSTIFHLKASFSSGPHLYTSPSPRSLPCSTSVDLGEPPRPSGAFRSRFRHLLTHPWPRPSHHYPYTLRSSERQFGQAACSCPASKVQLPSDNLKLIHSGISSSYTTLINTAIMVPSTLLAAANELRIDTSSASLADSDSGAELPAVEAAQLSPKMDRVRHHLIPARTTTCVRAPCLKRQASVPISSVSVDLAAQRLQPAPIHDRVASNPLPTSFAAPRNLSLSAGVRHVHFDESPPEEFYVLSGASYDRRPIKCTQGGSEFDMSLPPRSTSHNGDDSAEDDASSVDEAASAMESADEPAPDVGFFRDPTLENWACIKNGTVIASVGYQPRQQQSGLMASGKSLHFSALSSLQHASALASDDSKTSSTGLDSSGLYKTNNHASSQKVSLPVHGFRSFGGLQNSLAPDLTSPPIPAEPCRPPSKLPLSPETTPPTPRHASPDATPMPSPSLRKSIGAYASVGYFGISSDALQQSSLSSGSVDNGLSVEPVLGAMEVLRDVPSPSIAEPPAEVRSPGFPGPARLPEGPSSASTLAGTSSMPEVSTQQLTPRRVAMERRLADKETTRISTLQPPAHSHAGGSVTSLGWNSVLGAASSPLSSRCSSVDPWSSLSSDGDCDGTESPGNENSWNSSNCTSPDLSPFEQMAEGLNGKPPGGSSAARALSVSPDRRVEASAEAEALHLQGEADGATGNSWQHENTPKGLEFADEAKFSSSVETVHTTSWESRHVQAVASASVLAGLSSGEVSTSEATTPESSRRPSFHHGEMGLQRSSPRLRSSFGETGSALDHLDEDESQVMRVRSMSRDGHAKKKSTKCRFCRSLRQRLKGSSAESSAPTSSGGSAQMTDAESESAGASASAMGSMARASLHVRELTTSSAEVSEMEEEERGSRSPISHLRASVRSLSIESSGTSRSRSRDGYALSHLGIGREPQHDRESSNSPAESCSESAYLSAGGHVASMCTCDKKREKERLKKKLRRERELERERDREWERDQAKGRQKKLFGESFGDADNSCLSALDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEY3</accession>
    <name>W3VEY3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_06118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEY3"/>
    <dbReference type="HOGENOM" id="CLU_708219_0_0_1"/>
    <dbReference type="OrthoDB" id="3068835at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="354" mass="39820" checksum="ABF3900028FD30EB" modified="2014-03-19" version="1">MDTLITRYKDKLDRKDDRRRLKGKPLEQNSAACEDSKPYPKYFADPPATLPPPLVKPVFIPQRRQADRLRGFQLLYAPDLAASGVTEPEFLHFLNTLNAAIGFDNKVKILNFAVDVGTIACSSWEVLVATIGAQALTTTAMHVKSRAKSQAYIAHANQRYFHPRGLHAQIVPVSSVHAVSSPSNGVQQEETALEPSTFQFSLGSPNVLPLDHPKAKGGLLNLNKRPIDYDPFDYGPGYVRILPHQYAPIRPSQIKTPSTTLVDKMADKVESYNVWQDRLPAKKSVRREKKRQDTIGRIRCSEGEAGVLEFLRKEEARHEEKLDKNKLQHLMDRNKVILVVVNLDSRATGRQLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF33</accession>
    <name>W3VF33_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF33"/>
    <dbReference type="HOGENOM" id="CLU_1251140_0_0_1"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="1">
        <location>
            <begin position="37"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="226" mass="24222" checksum="F86A7E0E48387AF7" modified="2014-03-19" version="1">MAFGSTLSRCSRKHISAYGSVLDRFMVSNSASLASSSSSASSSSAASTSSSPSASLFEATKSEASGCWAPPKYSLRRQAKLVKEAALTGQLAALPDGPKTSRIQTRLARLAQSHAAEQQAAEYQYTPQHTATPVRPTALGQRTVKPSQRVPQTEHDAALAAARRLVKDVGPYAGRAKVFKGSRVDKNKITRAHAVNNKLEAMQSTVREWHTSQTEAKNKLKPGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFL9</accession>
    <name>W3VFL9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFL9"/>
    <dbReference type="HOGENOM" id="CLU_702067_0_0_1"/>
    <dbReference type="OrthoDB" id="2546048at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833121" evidence="1">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="414" mass="45038" checksum="7D575608B51EB9A2" modified="2014-03-19" version="1">MVFKKSLLIAALATAISSAQAAEPACKFQAGSWNELKISGQPIGVTHSGDVVVGGAPHLFSYAVCNSKTTGTKAKNQAVEGYIVDAYNTTQCLSLGKKEAQSAPITLSPCRFNKQGHVVHSQTFAWIPNGPDAVNATAYFKGVNDEPISKKSPPKYTLHYELQHPGLNGQLGRLMADYTPNLKALPEGQLTLSLEKHTGELPAKQAVLNCTEIIEGQLIYSNATARGNTYTGPLNAIWEADAKSADKFLLQKCDYSSLGFTETSKYAYGRLRPAADKASGFVTCYSMEGPLGGSGPTAVPARRPHITSIVPKPCTFNVAAGRDLVRYNKQTKTVKFVPYPHLRRTGSLYWYTQADYDKNFRVEQKLTSPKFIGQAYLDHNNVFLTKFRPGNVTFQADPVLNAQPATKVEQPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG40</accession>
    <name>W3VG40_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG40"/>
    <dbReference type="HOGENOM" id="CLU_018394_1_1_1"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="46463" checksum="96D6F622DC9943AD" modified="2014-03-19" version="1">MRGASLASSLALPLTTAFGGAQTLWWPSTTSSAPRVVLLFIPGNPGLATYYIDFLHAIYTSKHLTGAGIEIVAVSHRGHAPLPKVGTNAVWGDNGTNASQAARGWGTSLSDQVRHKIGVLDAIQRQYAREETKVVVVGHSIGAWMAGEILKARPDAVDGLHLLFPTMAWIGRTPNARRIKLLANRAVTAAVLPLPLLVLSLLPLWALVWVIRLLTRQPSAAALATAELLTTPGAVYNALTMAGQEFATVQALEKPTVDALHALTAERGGRIRSYWAADETDAWAPGWIRSQVESTLSLQRVHLAPSLGLGGAKKSEPSRRGSHVRTRSFSVSEYRSSPGSIPDLRHAKAIRRPNGEIVIEAQVVEPSSESESDEPTRGNSERGAQYHYGRARATATHCKLGMPHAFCLNHSEDMASIVAHWIAHDHLSNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG49</accession>
    <name>W3VG49_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG49"/>
    <dbReference type="HOGENOM" id="CLU_008597_0_0_1"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="70"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="847" mass="92267" checksum="C13A5F26F7234D2A" modified="2014-03-19" version="1">MAGASVSGAPKSARASATASASGSGRQDAVPRFGAWWTIMRSIGDMSLPVFFSSIHVSNASFVPPPTTPLIVCANHSNTIIDVAVLASHFPHRRPLHFWAKAGFFKNPITRSILTSSGNIKVDRRNKNNQALFQGTFRAMKAGGAIALFPEGGSYTIPYVADLKMGAAWAALEYARYLQLAEGGGMQKTQVEILPTAVVFDDKSKFRSRGLLRFGKPIRLDAYIDEFLSAPSPSDEPARGSAPRVKEDGTVPATPESMTRTNTSTGQASVESYASPAHRAVARLTADLQRAIEALTFNAPDWETFQATRAARELVFELEPDTLAELRAGMDEHVEVSRELMGLLTQQGEASTAARRALFVYACMLHLCDVDNLTLARVLRRSPAGWGSGLWSTVRAMALRLPLYIPVFGPTLVPMYLAPRAVAHHFARREEESLSSVKTLVGFVFTSTLYAALVVKTMQWTRWTPPGLLVGIAAVWWLHDLNRSNIDTAYGLVKQLRLGWRLWRAKPSSASTQRTRKSGRSMFFYGTLVHPRILARVIGSAGAHVRVQNAVLDGATLYHVRGEEYPGLVRTPTGMVKGTLVTGLTDADVQCLDAFEGDEYVRMRVGVLPDPSARVECNETRIANAGAAPLHAVLSSLTSERMEQVRARGEAVEDVEVAGREKLEERVWEFDVFAREHAARWIGEGAQAEHEHEYQVVDAVQANITATQTMTSTPPGETPPAAGKAWIESAASSLSSDVGIQEAIRCVCGQLSDKPSIQFYVDRAFAPRKRPSLSSPALLAALLAARQQARDALQSLVDSIAPDTGALDTLIAAHARALHSHHLQVQPHWPFTPAQYAATRTEPKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG90</accession>
    <name>W3VG90_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG90"/>
    <dbReference type="HOGENOM" id="CLU_063115_0_0_1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="194"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="35535" checksum="83463FB2B9EE7B5F" modified="2014-03-19" version="1">MAAVPKATLYTFDGSVWASAPRLALVEKGYAQTDLDLKIVDLLKGENFDPSFLRINSKGTVPTLVVPLLETTSAEVDTKFRAITDTKLILEFLDKSRSQNTLAASADAAAAPAPILAPATIEGKALSDELIALVHGPSVDPNFLLLGIRSEAELQKAKQGVPGTFVANRHAALVAHQKALENSASTTAFDGSTNPKSSAVHENLKKWYADKISSQALLTGAYVDGDKDAVAQLVKLTNEAWQNVAKCIEKLETKLTGPYALGDQISLADLHIVPWLARIAAVAQGVKPTSDPIASIDAVTAEYNVKVGQKITAFWQTFSERPSFKAVYGSGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGF7</accession>
    <name>W3VGF7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Wee1 kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_06204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001586_0_0_1"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000811">
        <property type="entry name" value="Cyclin-dependent kinase WEE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="752"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="811"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="999"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1337"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1341"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1072"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS59882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1482" mass="157894" checksum="419FFF25542E58B7" modified="2014-03-19" version="1">MTYTDDAFVSPHKASRSLRSIDVQLHTQSNMTPPPNFGSHAYHKSPFASWMDHIPSAPATASRAQPGAIPRSHAFAALAPLSKLSPTEECHPIDIDPSDHDELAPFASIKRTIPLQHLPSFADHNSQSHAADQDRWHHRGVSNGSGSDVSAASASAGIELHAVPGPSSQPMLRGGSRSLFGSSDSHRRSDGADMDVDMDIDSDADDAHAHAPASPSPMCDQPLLNDSATSFSIDLGEPMLQPGTRPTHRLARKHSSTTTTHTLTSTSAGAIHASSSQRLRPPRSRIPSATSPPLSGLPSPRLTTPARQRSSTAAGMELDDPMHSAIMATHPRAPHRARASSTAALHRPLSEFLTPRSASASAGLADKLPGVANLFEFATQPRPVIRATDRDAETTPLRDQRRRPANLSMSSFPTAKLFEDEIEAVKSSTGRDTLDSMPADLDTERLDLVSTPARRQSAHSRGFGSDVSAQFLQTPQSATPLRLFGGVHASGAADDSGVAFADNDASIKSNRKRMGSTLAPIKDSPAPSPSLLSNMLEGLSSPSQDALRRHEAAFRRDSPAARASAQTGLHAFGPKERSSLMHETRFSTPSEGDSANSSPDPIPRVRSRTSTSTASPARRLHERRFTSEAGDTASTQYLTPQNFKSVKPLQAAFMSTGLVSKRNRARENSEGADASSDSFQFPPKPPNFGHALGLREVVAAASAHATVDRTTNAMPDTPVKKATSTPLVPFPKFASALRGQINVNTATLGPSPLGAASPAKEFSPGGSGTGSPVITDSCDSPTLSLMQLGLPNASTPATLSGRHGLAYAGLPRSRRSAHSAQGSQTLSQDETTEDEGGLSDVSHSPSVQTGRIRDVHRLQKGKRTIPTPSPGGAHAPTRKMLSVDTVKAAGAPKTLRVRSAGLGKRTMSRNASFARDAKNSADGVTELDAGGLPPSTPLTSHATLTPGEGDAAPMTPTRNAAQIKWFEAAQVLTTPSPSSRRQAAHKLRAHRLELMQTRRKSRLSETSTCQDTPQKATPGGSALVLGSNESSRAHEHSILESAFNVEETIGSGEFSEVLKAVSRSTGYAYAVKRMKRSYLGPRDRLRRLEEVDVLRTLSTSGKPHANIVSLFAAWEEEGHLHLQLELCPLGSLAFFLEEYGQQVGALDEPRLWKMLAELSSGVSYIHAHNILHLDLKPANVLITEHGTLKIGDFGMATRWPLVDAETTLRGAGLDAELRQNALEQVAEPWPAQRGLEREGDRYGKAADVFSLGLIVLEAAGNVELPDNGEPWQKLRRDDFSDVDLSALSGPLLRVLTRLLCSDPEQRATVDEISALPTVACVRSIMSRGLSASEMDQLPEFTESSTSGSLSGLAESVSGHSIPSELSTRTLGLSDSETGSSATDVLSETDSALGLCGLSSSMSAQTSISASTSTCAVLRVRGALIQEPEEEFMREVLAADVDEARQIVKGSDTARWAAERPVLMPLQEVQHYSRHAAGMELDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGP4</accession>
    <name>W3VGP4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease exonuclease phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGP4"/>
    <dbReference type="HOGENOM" id="CLU_070126_0_0_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833144" evidence="1">
        <location>
            <begin position="21"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="299" mass="31841" checksum="32A6A89C020D60E9" modified="2014-03-19" version="1">MKTSLLLLASLLKLATMALAAPTASGSLTAVTMNVAGLPSILNSNGDSDKKANSVAIGKKFAQYNYNLINVQEDFNYHAYIYDNDNHPYRTPTSGGVPFGSGLNTLATIPFKDLSRVKWAKCNLNEGDCLTPKGYTVVTLQLPTGGEVDVFNLHMDAGSDAGDSTARTSNFNQVASAIASRSDAAGRAVIVMGDTNSRYTRPADNLAAFLSQTKLVDTWVELVRAGKAPASTDPALVCADPVPTTTNCEVVDKVLYKNGKNVTLKPSDWQYLGTQFTDASGKPLSDHTPISVTFTYTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGW4</accession>
    <name>W3VGW4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF962 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGW4"/>
    <dbReference type="HOGENOM" id="CLU_081702_1_0_1"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24111" checksum="D95E47942C4A7AE5" modified="2014-03-19" version="1">MSATVNPFNLRKQLAFYGAYHTNPVNVGIHILGVPSIIFATSALLAKQGTIFPYVQDHFPLAAAYLSQAGSQLAAVLPAKVFEYAQLNLAAVFMGSYWLYYSVLDTTAALLLAPIWYALWYGSTVLARTRPDATKIAVGIKAFGWISQFYGHGVHEGRAPALLDNLLGAVVLAPFFVFLEVIFHFGYRPQLQKELKNDVGVLVTRFRTEKAKAKRGKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH77</accession>
    <name>W3VH77_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000873_0_0_1"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="539"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="1605"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1227"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1303"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1423"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2025"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1307"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1317"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1486"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1510"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1539"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1564"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2028"/>
            <end position="2043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2242" mass="239628" checksum="6E7C020F1859EA1E" modified="2014-03-19" version="1">MAGRELLQVLLPGNAAILSASIPSSASTSVQDLIVALLTDRTNTHSLTAAFGSHFQPWPSANSNDFESSEKWLIDHNGQLWGIQAVQAAPPNYEWSEPELRAIDDGIIPLHTGVFAFLRSLVDAPKPAEDRDVQPPPPDLSSPTAFSDFLLSSHLHTPRLRLVCGASGLRVRLRFGHVPEIYDGWDQRSWFLPADPTSPGATGVGSTAVELVEAVCEELGIRRVVLQGSKSARVVYALAPLPSTPASAPAPMPPPAPLPDTTSLPNYLAGSSTSDAALMFTISASWLSKLGTVAQGFSKHARRQGSNGVPAAVPTPDRSQPALSTSPTKQASAKSGMLGLWGSASVSKATAALLPATFSTRSRSASQASQSTGDAELDALSVKLASTRLPDDQDDEDDDAAGGTLKGSKPSTPADRSAKLPGPEAHSTPQDDENESTINIPKGRRHQPPSATARLSRMFEGWIGGGAETASPSSPKAGDEAAAMPETPPNQPVRREPGTVGRSGKTFSVSGPLELESDTSTVSPSPSLGSLNQLSPAHAALDDPDELEKRFEKLMQDLGIKGTSRSAMLALPNDRKRFLISQNEAAKTSTPSKPRASLGQQGDKPVSPTLGTDTMGRNSIIPAGWSNRFSISSIATWATSDTHGSGSGSHKDFDGPSSPRASVSGDASSRGSESTRPTTVLSDTGSLGSLDSKALNGGEHTIKANHTGSSAGVTASLWNNWWGGGSTISAAGGHDQLGSSDERQVAMNHVTRLKDSKPSRKDLFKHLLSLRVTLSSAKLSWIDSFLHCDGLGALEHIMQQETDGIVKGLDINRAKSAERKDMSDAILLEAVKCLRTLMNIELGFERVLEQPNLVNYIAFALRSPSYKLRLQVADVLAALCVLSLEDGHRMVCGALSELKVVSGERYRFAFLVEDLKLHASSDGLEGADLDDSDASEAIEWEYKAAAMVLVNAITNSPEDLEERISLRDEFARRGLNEVLVSLRYVDPPENLATQIQVYVEEKQEDQDELHDRALHLSDRERERDREAISHLGEAGEILRRSQNDHEDLYPIMISILRHTSNILDRDIDHQFKTDLLFVVDKYVESSADVADFDEGWRSFMRAYLANIQHLVGKQAMIKANRMSDTSTVPSSFIEELEGLRAKVEELSDDKAKLRTKLNEQTAEVITLRSLPGAAALRRESPDTENGPAGTPSTLPKRGDKENFAGVIQRLVAKEKQVIELQEELDRLSSAARPNDRSDGDDRAKKDRLERNRQWTNLMDEIARHKEQLAGAEANVEAKEREIKYLKRALEAVYGRFQNGLAQAQEEAEAKDKEQESSKSGSSAANSEMEADMMARRTIEALSKKDAEISELRADVAKLQEKALKSIEATASQDQTEALRTQLEEKDKQITKLRSEMAKLQALLLQLQIQPAAADGAGAGLARAATVHRQAPRPPGAPAPPAAAAGHRTAPLPPAQPGMSSANAVAPTPNGESIVNGGESPGSADVSPPPPPPPAPPAPPAVPSFSAGVGSPPPPPPPPPPPAPPAPGMHAAPSFGGSMPGPPPPPPPPPPGPPGASMGALGGGAPPPPPPPPPGGAAGAPPPPPPPPAGLVPPPPPGMLGAPKPPALPLIPKKKRKALFWNKIPAHSLSRTVWNDMPEASVDVNREIERIDELFSIGSRPAAAVPDAKQTGRKANPTTLLDLTRAQNVSIVLTRIKVPFPELRIALLQCDETKLSVDNLKSIKSCLPTTEELELVRDYDGDVGALSKADQFFKEMLGIPRLSERLACMVYMRKFELDLEELKPDLRILKHAADEMNTSAKFKKVLHTVLTIGNVLNSATFRGEAAGFQLGDLLKLKDTKPSQPKAGTPTLLHYLVRVLNQTDKTLVGFLDDCSHVEAAARLSTQAIMQSIAALVAGHEAMQNEMATLDRIGISSQSDRFVTVTAEFLRQSVPQIKALQLAGSTIQTSLSQLLSYFGEDPTQTKPEDFFGLVSSFGQALMRAEEDTLQADRKAELEEQKKQKAAFGKGLYGMRIPQFGPEVRGPLGVQKGDAGAAPGKAEAEVGGAVGGPQPTSAEEMLEATDQLSPVNEATPTASRFRSWGASAAAQMAADASLANEGGDKTTLKAERGAYEAGRRSYRGRGQLDEAIKELRAGAAGRKLANALAAQHGRDEAGSSPSRIRNVVRNSPAPEVEEEEVDTATIGRTRFGSVASRAGRDSIYATMSANPNGTLSGRKSLRLKQPTRRPLSRVFITGDPVNRDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHA2</accession>
    <name>W3VHA2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHA2"/>
    <dbReference type="HOGENOM" id="CLU_280192_0_0_1"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000026">
        <property type="entry name" value="Ovarian tumor-like cysteine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="572"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1122" mass="121197" checksum="3A59B89F14C6E105" modified="2014-03-19" version="1">MRASLALPSTIAFASSHASPMPSLTESLTWAAALDRFLRGSQSVVPVPGGDDIEWQQFSGKNLSCRVVFSQPSTDASTKAGSREAGISSATSWKLSSDRQLRITVQCGSTKTSDDQSEARSVAPSTCVERVEPEDVDLVSVNRTYYHTDHRLGAVETAHRGLVIGIRYLDQLDASKLHFSREEDKSFFLGLIEPESTMRAPLTASAKLAAPASSATPTQASTSGQIDESQSQSGSLLQRLVEMKAVPVAPKIDDGQEINAGGPSNILHVGTAVDLAPHDVQYGWQSQESPQAWRCLSCGSSDMTTPGTQTAHTEQTLVDTDCTVDDAAYEGWPCPSAVDCIVADVRRLCLPNPALADLVDRCIEDVLSGCSLDQSQGEVKTQADPPIRTLAIPRRRRRDAPAPLSSSPALHPLEQAATLGKSSNPTPVHLASCGDQHRHIYAPRLAPQPQCRVRIVIQYHHRLASVSITAFNLRLPLQLDLAKLASSPSALSSIHPCTQHPNLGATPPISPSSMRTPQRAAAAGPSRRSNRAAATLKNERITRSSRAKNSYALDDPEQVERDLNSQLKRMGLYAANTTGDGNCLFRALSDQLYGYPGRHAELRQETCDHLAERPDKFAGFVDDKPFEEYVRLMRENGTYGGHLELHAFAQMKQKQIKIVQPGLVYVVEGVDDSPEALRAREAKEQERLRVQNSIEAGTDAGPLTERQRRRQKREETKREKVSRVDGADPSASTPSPNAAQTGTTTEAEDATSSQATASTSTSSQDASTSTLQQPPEAYGPLYIAYHNWEHYSSIRNLDGPHSGLPRIKEQIAAAAAASDADSRSTVKDDAEPTTEEKMVLQSISGDHDLQEVRRLLRENLNDWAHVVELLVEKDTIIDEEEVGAELQAVSSPGEASANAAERSTLAAPTPLPDHMRRWRATSPSSVDTSATHSSGEGDSPSTTATTDDGGDTTACASPEASSGSRGSTPGVERLSSKRAASSDAMTMSMIRSPKRRSQSRSPDFNALPDSQPDEEGNGSAAEATATTTTAEDEAQEGETVYEIIKRGRGRPRKDGLPNKSSIAVKRRVPTAREKRDAAQARKRERQLEKVGRARARLTGDETASSSPRPSPAEVCGFRELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHH9</accession>
    <name>W3VHH9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHH9"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="75"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="578" mass="63888" checksum="9DF1336B0720CD8C" modified="2014-03-19" version="1">MDSPGSPTRAAATPTHEPKLSKDGTPDLYKTSSLREVDSSDFPELAEPFWSKFIPPIYNEKRVLKLTAFQMTWAVQMVAGIAVMFFGFDQGVMSGVNESKDYLRLMGTDSGVNGSQTERDSAAIGGIVAIYYLGTLIGGLGGGYIADSVGRMKAILFGSVWVVLGASLQASAQNITWMMFARVLCGFGTGTYNAVVPVWVAELSKHDKRGQAIGFEFVCNIFGLMLVYWLSFGVRNIETNGFNWRFPLAFQLVFVAMLLVALPFFPESPRWLAKMGRVDEAKRILTRLRSHPYNENDPAVTAELQEILQVAKLERIRMEKGEDGFISQLVSSSGKLHLRRRIILVVWLQILQELAGIGVVTVYAPTVFRSGGFGDTLARLLSGFNDVSYMFAVFISVFTLDRTGRRKALYWGNIIMGISLFIAGVAAKYALEYGPESVSPDLALAKRWGAVLASMIFIYTAAFAAGWLAIPWLYPTEVFPLFIRAKGGSWSVFGWSIGNGVVTEITPFLFNAIKYNTFFLFGALNFFCMPFIWAFYPETSCRSLESIDELFEGSSAFIAFDKRLTSVGSQKVADETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHI7</accession>
    <name>W3VHI7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHI7"/>
    <dbReference type="HOGENOM" id="CLU_2062481_0_0_1"/>
    <dbReference type="OrthoDB" id="10269314at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="119" mass="13625" checksum="6FB0A67FEB13A275" modified="2014-03-19" version="1">MGDFGHDFNKFLEIVTEIYNKYGSLDDYARGEGVWRFRVFGMYTVTARAIMEYNGMDQYDTSLFGAQKLLDDIVGTTDWAQLSESHLCHRQDQAHGCFVHHLTGTMYSIVLDVRALGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHN0</accession>
    <name>W3VHN0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHN0"/>
    <dbReference type="HOGENOM" id="CLU_025095_2_2_1"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000233">
        <property type="entry name" value="Related to GRH1-acetylated protein, involved in ER to Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="142"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="335" mass="36449" checksum="B89271ED4EB67CB5" modified="2014-03-19" version="1">MGASESRLRVEDSDDAPKQGYHVVRVAAGSPAHLAGIEPFFDFCVGIDGVALDPTKDVDGAGDTTGLGAWKSLEEREGTQVVLNVWNSKRQQLRQVPLVPSRQWSSQPSTSSINGTSSEATSQPSLLGLSLRLCNPSQALSHVWHILEILEGSPAESAGLVPFGDFVIGWPGGVLQAEGDFYELVEAHTDRALRLYVYNSDYDHTREVIIVPNREWGGEGLLGCGVGYGLLHRIPKPQDLPQVPPELEGRDAVPEDQLQTPRIGGPPSAFATPSNSRLQEDEFSTPLANPSTRYTSSYSGHPDPEFTEQDEDDYEANTSGVTVSMRHDEEDEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHT3</accession>
    <name>W3VHT3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHT3"/>
    <dbReference type="HOGENOM" id="CLU_024645_3_0_1"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="50649" checksum="45A6F13A32F0845F" modified="2014-03-19" version="1">MATTVMFGLSLKQVSLAVLTIQNTALGVVMHHSRVSAPIGKSYFFPTAVLLTEFLKCAISFLIAAASTRPATASLPLPSASASASLRQRQQPHSNDSSAHARLLTSPSHKSHDSISRLQLVLDEVTAHDYWKLSIPAFLYVLQNNLQYVAVSNLEPPIFICAYQMKILTTAFFSIVLLRKKIGMWQWMSLAMLAIGVAVVQIQSKSVSGLVPFEVRTHGYGHVSAGPVADLPPPPPPPPFDSHRAPPPERLPSLGSFLSGSDAKDYDHLPPSSPSFPHDRISMSMEESAKADKPMQPIQGFLAVIAACLTSGLAGVYFEMVLKTSNVNLWTRNVQLSAWSLIPAALPVLLEMVRHGPSAPFLHFGISAWATVVLQVTGGLAVAMVIKHADNILKGFAVSFSIILSFGVSIIFFHFPFTAPLALGVALVILSTLSYSRGSIPGFKTTAASWSSPASSITSTFRDKARLLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHX2</accession>
    <name>W3VHX2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHX2"/>
    <dbReference type="HOGENOM" id="CLU_105927_0_0_1"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10178">
        <property type="entry name" value="PAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="177" mass="18907" checksum="093BE0A65300F450" modified="2014-03-19" version="1">MMASNPASGFEMQISATQIPSSSPVLPTRTASETVGGAPTTVITQSFADRIMITITQLNKFGCIYQATTSIDPADPLPQHNDAGALPAPLPTTAVTKLVGTEPSPAYTALYHLYIAQLASIVKHAAPTDQRPLIVTLALKPAAQEQQDDEDDSLMSSEAERSRYMAIMNMVGSCRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI24</accession>
    <name>W3VI24_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI24"/>
    <dbReference type="ESTHER" id="psea3-m9mfk8">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_16_2_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004104">
        <property type="term" value="F:cholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="22"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="575" mass="61038" checksum="E4A36C04BC1674E2" modified="2014-03-19" version="1">MCAGAPVLTCRADRRCSLSSPLQVNLALGSVLGTNTAYGSQRFTLPYAQPPVGELRFAAPQPLTALPNRTAAYDASQLPKACMQQPDSRYGIAADNVSEDCLYLNVFRPKPSTEGPLPVLVWVHGGSFIAGSSTAPGLDASYLAAQNNVVVVTIQYRLGMFGFFAPEQFTDESQVGPGAKLSGNQGVRDAIQALKFVHDNIGAFGGDASSVTLAGQSSGAHLIRTLLSTPSATSLFHKAILHSDPANFGTQTASTSDAVSRYAMGQTSCSDVACLRAMSAGDVLDASMQTVQAAQSIDDAVAVSEVWRPFVGQLTGTPFEANPAAVASKPIIVTNVENEAGSVIGNLLLPTGMNHDTAEMRAWPMSLSRQQLLGQMFNGGRADVLDSTTQYSMATNVSAYPAPVQVKLYSSAQDGLRRNLETVLTQGMFTCAAWNNARRYAAAGQVYVGLFERGITYPTNEGNDYCAQDKVCHEDDIRLVFADPSQVDESKRAVVQEVQARWVAFMRSGNPNTANYAAWQTVSTSSQSAHVLRLGSADASGAASTLDTISLQANQYAGCGQVWGSTAKFDWQLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI84</accession>
    <name>W3VI84_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI84"/>
    <dbReference type="HOGENOM" id="CLU_011226_14_2_1"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF14">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="97"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25347" checksum="4767F7E87DC4B687" modified="2014-03-19" version="1">MSTQYTLYSHRGPGPNPLKAAVLMEHLGLSYDVVPLDFGDDPEKGVKGAKFLKINPNGRVPCLVSNDSDKFSVWESGAILYYLCDKHDKEGKFLGKSTEERAIVMQWLTHQLSGLGPVQGNVNYLVHYWQGTYGEEPQKSAFTRFEGEAARLYQVLEDQLKKQQQRGSSFIALDRPTIADFAFWTWVRIASFGNIDLSPYPAVQKWCATIENDAKSQAAVAKLPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIS1</accession>
    <name>W3VIS1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">PaG_04321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIS1"/>
    <dbReference type="HOGENOM" id="CLU_071894_0_0_1"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="246" mass="26263" checksum="D1C3380D70183A95" modified="2014-03-19" version="1">MAVRCQFENSSEIGVFARLTNAYCLVAIGGSANFYSTFEAELADVIPVVHCSIAGTRLVGRLTVGNRHGLLVPSTTTDQELQHLRNSLPESVAIQRVEERLSALGNVIACNDYVALVHPDLDRETEEIIADVLKVEVFRQTVGDNVLVGSYSAISNQGALTHPRTSLQDQDELSSLLQVPLVAGTVNRGSDLIGAGLVVNDFAAFCGTDATATEISVIESVFRLTGAGNGQDTVNELRDALVDTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIV3</accession>
    <name>W3VIV3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIV3"/>
    <dbReference type="HOGENOM" id="CLU_040308_0_0_1"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="55249" checksum="CC8A69FB394110E5" modified="2014-03-19" version="1">MQRSLHRKVGAGHAVASQPVSSAVALDVACRSLDMPRHRRSYKHKDFLLSLTDDASSKPIDNHRSKLLRTPSSRKDHAFSSSWIDIKMGRLPETSSADSMLEQRASAGTIGQSAINTPAQQSAHALRKWISLSTLVLFTTATSVVSQRSRSVGPDKQYSIATSVFLSELLKFLLGFALATVARDASPTTDPARLPLFSADDPEGSEKLAREAQGTRYAAAPPSLSAKAQRAWNDVYCASTWMMGVPALIYVCQNMLQLAANSHLSPVAYQGLSQLKLITAALISVFVFGRPLSKRQWTCLPVLLLGVVFLTQKKVPSHEEVAEAASLLREVPTDSPFGRKVGSGSTLLSTNLMAQAASMLREDASAQLAIGTACVVLACVCGSFAGVYIETKLKSSMSVALSVRNAQLASFALVTAGVAVVLEMMQKGEWGPLRNFSTLAWTTVLLRGGSGYVVSATLRYADTIMKGFATSMAIITTIALESLLSSRLPTLAQLTGGALVMASTYNYVRLSAIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIX2</accession>
    <name>W3VIX2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04502</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIX2"/>
    <dbReference type="HOGENOM" id="CLU_007574_1_1_1"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="693" mass="77199" checksum="B8DBE5E087D1203A" modified="2014-03-19" version="1">MARPRPRSGSSAAAPAQSLESLEQEALELLGQRKRRQRVRYSCTECHRRKHKCDRETPCSKCIERGVADACTPHDGSAQDAHDRVRQLETVLSRLVHATRSTGGSSSPRAGSSALGTPDASQAGTPRRKSNPGVATAASLPFRAQVGSELIEFSSSNHGYPPSAHYERLVREGSIEKDAIRILASDLPSLDDTNALLDVFFRDINPLMFPFDEMWFREAVHSAADIIWGDPSTTYGQDGPNHLSVIALLYGVLALTYLAQPLQMGSEARGAERAARMAWRCREVHALAQSIQCHDAFVVLSYVLLARYLILQRQARESWLVLGHAVRQAQVLGLHRMGKAEEEEAREAAMRRVIWMHLFFEDRFSSLIVGQAPLINEAFCNTQPPLSKTMDTDREQLDLAQVVRVRHELSRIVGEALELFLSDEREMCYEAVLRLDHQLELFRDALPSPYRTDSCIDNADGAQRHVALHRFVLHISLYYVVISVHLPYLRHGGGDAAFERSRQVAMEAAVGDHAARVRLRDELEWPAHMARDAFVGGRFFYFHATSTLGICLLSEPDERKVREMLPLLDEFLQFAREHQRQTGVDPDRCIRQEISIVSLIRSRVLRRAESRSTATPHKGGGAASGPSVVTGGLAQEQHEVQQTTAEGAAWPAGMVELGQPSAGADVYDWWTWLVSSLSPSDLPSLVDPHARTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIY1</accession>
    <name>W3VIY1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine racemase</fullName>
            <ecNumber evidence="9">5.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">D-serine dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">L-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-serine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04609</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-serine = D-serine</text>
            <dbReference type="Rhea" id="RHEA:10980"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="5.1.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.18" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIY1"/>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_1"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006563">
        <property type="term" value="P:L-serine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000041">
        <property type="entry name" value="Threonine ammonia-lyase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="56"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="258"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="450" mass="47757" checksum="521CE8584AF747C3" modified="2014-03-19" version="1">MSTPSSSSANLVSLEDIQKAHARVAPFTHYTPLLTNQAVDSLVTEALFAETEASSPRVRVAFKAEHLQRVGAFKYRGATNSVLVHLEAAKAQRETDTTQQGEFSADRLVVVTHSSGNHAAALACAARSAGCIAAVVMPENAPKPKKEAVAGYGARITLCKPTLEARESTAKAVMDSYEEQGYTVRFVHPYDEPLVIAGQGTLALEMLDQAPNLESRGACSHAAESKSSTSRPLFGSKNVVAVGPKADGTWRARDPSEPVFDIVIAPVGGGGMLSGVSTAVKGADSRIVVIGAEPDLVNDAFHSVQTGEVQSPPQPPKTICDGLLTSLSPLTLSHIQKNVDTIVTAREENVLKALQLHWTRQKQFVEPSAAVGLATLLQGFNEAAQQLGASSDADTPSDRSLWGLKHWVRAIAQQKAQAGEKQPEIRIGVVWSGGNVEVAKVAAKFEEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIY8</accession>
    <name>W3VIY8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="15">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_04614</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="15"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIY8"/>
    <dbReference type="HOGENOM" id="CLU_811814_0_0_1"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 15" id="KW-0274">FAD</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="17">
        <location>
            <begin position="219"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS60711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="344" mass="37773" checksum="747D05DB62CFA07C" modified="2014-03-19" version="1">MPTFESKPLRKSSSFVARLAPQVRRRPLLFFGIPFIATIVGASFGLANLTQTRYDYNATKVQTISKEEELRMKKDRKRIDIREEYFKLQSKQDELDEWEPKRIERPDGVAEWGVAPANYRSIEAEGLSPRDAEQEKNKGITAENVQSSRKQPPVVLGPDGKPCRACNSKLAFAAAMKGAKQPSSTKTGTSSGAVKAGAGAALAASALSTDSDAPQSRACPPDGEELGRSAWTFLHSAAAYFPEDPSAQQQTSMLAVFRALPHIYPCHSCAEALGEEYKREKTEGGWEDRSLRLSEAVRSGPALRKWLCGIHNEVNQRLGKPTFPCTEAKLAERWLDGPADGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ00</accession>
    <name>W3VJ00_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ00"/>
    <dbReference type="HOGENOM" id="CLU_696757_0_0_1"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="87"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="363" mass="39618" checksum="B1F9E8B28DACC39F" modified="2014-03-19" version="1">MSGTGDALEAAILQGVDANPASTYREDRRASSSHSAPNTDDELGSDLSHHDDDRHLYQRDDEDDLPASSTSPRGGDAVKGVQNSRTANRGAEGATNTGPKGVLRDQQLRAAQESAARSAAVHATNRRMESLALSSETYTQQVERERREAALRLQHELDDDQHTVSREAIADLQAKERRREARIAELKAFHASRSAADPTASAGVGSNERWFGHLREVDERGYVAAIDNELHDVPIVIHIYSKAVEQCNVLTAALAALARVYPRTKFLQVQAAAIGFGHSPEDSDEEFDELNPKTLEVLPTLLVYRAGKLVANLVRVDLDPLWNHGSEQDLRTLLQHHGAIPTSSQPAPLATDPFSAHVDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJS0</accession>
    <name>W3VJS0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJS0"/>
    <dbReference type="HOGENOM" id="CLU_029148_1_0_1"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="295"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="60849" checksum="2304049258035694" modified="2014-03-19" version="1">MSPAKVSTATATPSKLVNGTPKSAKKLSANASPSKSAASSSSASATVNGSSASASTSSAAASTSTATQEKPTGKYYDSLSKHNTAFTSLLHLIPPQFYLTRDDDDLAEDVSSKYMKNKRKKAKSEIEAKERKDKLREAKKQRLDPDNFATVTDIQAERAAAKAARQAAQADSDLEVDAEGMVSDDDDEDDDDDDDDDDDDTRGGGAAGDTDDEMQDSDVEDLPSKPAAAAAAAADPTAAAAAKPIQTEGERKASIDALRAKLHAKIAGLQRKRGGLLADAEEGSEDGSSVISSKDELLEERRRQRFDARERKKQEKKEAKAAAKQAAKAKKAANANGAAANGTKSGSTFNVATKAPALLVAEPGYGDKDKRAAGSGAADIDVNGNSLNFSSLNFKPVGAAGAALPDEAGAGGKKSKLALPSDPKAALQMLEHRKKQDEARRAKLAEKLGDAPEALSAKVTELDEQKKWDKVLASATGVKIRDDEKLLKKAAKRKDKQKEKSSKAWNERAQAEQKQQADRQKKRQDNIAARKAAKGGKGGSKKGSSSTLSASKTPKGKRPSFGKARPGFEGKKIGRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJU5</accession>
    <name>W3VJU5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJU5"/>
    <dbReference type="HOGENOM" id="CLU_373430_0_0_1"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="744" mass="81473" checksum="0B4AD9EA1CAB7CED" modified="2014-03-19" version="1">MSAAALVSALPPLARVWHQDDPSVRVVQVDNTTDPNATFQRESVGTTGNIVDMVICCLSFLGAIAIILPYVLNRRSRKLRHALILGLATSDLATSVVIIITTACLIANINLVQHHQPCTLLGYILVSSIFSQHLWNLSIAIVTYMILVHPLSNFTLTVEKRVRWLWPIFWLLSFAINAIPFALGGFGFRGGYCAFTTPFLFTSLFQFVPRAVVFVVILCLYTHLFFFLRRTNLFSRANHSNSLSRSRQRSANPQSQPQLNANAAHHQALLVAPPAPQEHASSAPSSSTEHSTKTSNASRIAPPVLNKNDPTLARRRSSSLGEKDASVEMTTLDPASRRRNHSYADAYSKDDEDNADTSLSGLLSYTGPRGVMDPNYTMASPRTRMPAQLDIERANAPHYDASSITAHSPSNASSAGAGPSASLSAKGSSAPLNASFPRGSDDAQRPTASRRPVTAGASGAEKREASTARRASAGDSRYATARDTDVESVDSDEGSRRMRPRKDAGDFDMMTPPVEHLKHYTAPVRSYARMADILAMGDDEMARARTGLASDRRSSAVQILPGEVVVEMPSKEAFEESLGDDWNWGMDVTTKNEHARSSKRVRDDTGLHTGTSSTSSQDENGVESIGSTLNRQASLLLLLYPAAYCLLFSISIARLAVDLADPAASVRNAHDWLHQLSRWLIFAQGAIDAIIFQFIERQFRQRMKRRRRKAMGEPINDSFSHRVGKLAVAQVKRSLHKASQTTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJU6</accession>
    <name>W3VJU6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJU6"/>
    <dbReference type="HOGENOM" id="CLU_313767_0_0_1"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="515"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="754"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="844"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="901"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="933" mass="98377" checksum="89E99D8A661AD404" modified="2014-03-19" version="1">MASASQAGSFQARSATVSRVTNETKIEVSLSLDTHPTFAPQTINVKTGIGFLDHMLHALAKHGGMSLTLACEGDLWIDDHHTAEDCALALGAAFKKALGPVKGIKRYGTGHAPLDEALSRAVIDISSRPYCVAELGLKREKIGDLSCEMIPHVFHSFAMEAGVTLHVDCLRGDNDHHRSESAFKALALAIKEAISRTGTDDVPSTKGASSLSLEFDLFFAIATSRTLLALECWSWQRTRLAETSIAMGARLGPCCILIMMAIDVTRHVGPAQTVAARSTLHRLSLPLLTLQHDVTCLDVSVMEANGVEIGWTLLGACEETPPHRIRTNPTRRRKPHNNTLSSSLRRVSLRPPATHLAALEPLDIGLIRLALSQSLRTIVHRTSTTTMASPVPHTNTARAPLAELPLHQFVSQSLAASPTSNSEKLLKTPSRSRSRSPSLSRSRRGSLSVSPHKQAVLQNHRLVREGSVASPSSSSSPSEPMADTDVSLRPRRLFESSGQAGLDLEASPVLAAATSAGSRFSPRNVGNLVHHSPGRPSTPKGASTTPLNTRHHRPPHTSGPKPDKFVEPSPTTQRVSEPRLPATRRRDQDAAAATSTPSRTRIRQLSAAAETQTEMAAAGATTPVEDPIQAASSAVLQSLPKKKHRVSRTEVAIAHEEAGAGPMASPSPRKMTDYFSPSQDEPGASVSGLALSRRRADSITLDAAAVASLPSLAGLGTKTSANGLALAQSGLFLGLVARPLPGWTVYEDASPDALASQDTAPSQDHAASESDALSAASSPMSSPARNAPSTPNKENRRPDASLLASMVVPMALPDRAYSVDILPAKTGAASRKRGTGGRLSLLADAEDGDAAKEALQQDGEDGDNSALSGWGKKPKSRVHHGSAAGTPASGTRKASAHQRKASAGSRKASSTHGVDAAVSVDAVASRTRSRTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK43</accession>
    <name>W3VK43_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK43"/>
    <dbReference type="HOGENOM" id="CLU_801986_0_0_1"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="1">
        <location>
            <begin position="112"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="346" mass="38715" checksum="C62AE07C1E2CF27E" modified="2014-03-19" version="1">MLDPWLAQVANVKANASGDIAIGPPRQAHRTTIVNRASLNKGITITPLRPPERAIEVSDDEFDDAELDAIMAWIPLPTPTRQVSGHGLDVGLGVQGEVLAAITRSALEQARVLDQVDGKFIVCITMVERQQVVFCVDQHAADERYQLERFLEEYATRCADRTAAHIIEAAVTIDVSTNQYESLKSTSVRREMRRLGWMMQLVPRMAQVDISGVPYVLKDRTLTLKGRPKNQAMLRDVFASCLEDITRRQTDLEQHRRNGQGEQKIAQTNETGDWISFTRLLPAALLEVVKSKACRSAIMFNDAVGREVCERIVRRLTKCKFPFQCAHGRPTLVPNCQIVSQPSNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK71</accession>
    <name>W3VK71_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04053</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244858_0_0_1"/>
    <dbReference type="OrthoDB" id="2543194at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="9">
        <location>
            <begin position="439"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="865"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="1519"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1587" mass="177319" checksum="D4FF84A6A6D6F17C" modified="2014-03-19" version="1">MRLLPQPSYSHIFSSPRALALALGRAALKSERHGQPVRLHGRQRLEAQAQSAAPVCRLTPTALHLRAGRPSSFLLGAAALRVELDSAKVQRRPSTYLRRHFARRCVLPSVHNIHIPPRPSGSTAVSLPCAIPVMPASDGEHDPYSSDLDDTISFFDHETDLLSFTDFEDYEICRDYLDEKLYHLEGLVAESEDYLREVRWEFEAYDPPATRGEKAHLTRISNKTDKARKRLESFKTTKSTLLQQLVEFEGAHSLRLEMAEDQAAEERRMEEIASLPQLSSLALEASGTPDLQAAWDRKDHEMLVQLASTLIEDASGAPGRDDLDGIRHLCTGLRLRFKAYTAMRLYSLAVGDASRLLDLLTTYGADVQADDDLEVASTAGTQSEPVARRRSARLSQPRGQKRSATPKASGGHQNKRSRLVRSSQCQPQPEPTSGNDGETISILYFPVELILMIANHLSITDRLHLANTCHDWRRIPQLWQSLNFRRTKSTGKDGWHYDTVQACVTAIEICQRRSHGTLTCVKLQGFVTSSAVGPILDVLQLSSATLQHVAIPTLDQKLCFDRLYYRCPNLTGIDVRFACTSEATLVIQDPNRVTSPFQSDTLPFQLRSFYSRSDLPYGPLTSHMEGLQVVHCMAYKRQKKLSFVDGLLRAAPTLVEWWDDVGADWYRSVINLGDYGIERLAVSPLVFPKLRRLNALWSEIFIDCEFPALREARINSMRGPSTLDPSTSTTFSRAAAIITASPLLKKLEILLPPGFSAQRQIYVAISKLRHLEELTLCTTDSSLSLRPLLDAEEELATPKSAAQETMPALQTLRIILKTCGRGNDTLVNELVELLLIRYYRREGHTYSEAKTKMTQARQAYQAYLSSLNKPPKPPKPPAKKTAKKKKGANDAVEEPLDTKEDVKPPKFTSVLSQLVLPPEKVYERGEMRSWWRKSDTVLSQLIFQIVEAENPKDSGFFRGWGSKTQGMSAVVGRNGMSQWHSALHLSSILALGPQPVMTSTSAPTPSLLVDDRFVLIGTLALASHLLLFRLVDLWPEQIAKLYAGLFALDLTVRYTYLHSGIVATVLATIVDVVAYTVFVLASIGVYRLKFHRIADVPGPKAWALSKWSTFGIDRQGLRPRAVHAAHVEYGDVVRTGPCEVSINSPDAVAAISAAKSECWKGPWYDGAAGGREPHIMRSLINLTDRTEHQRRRKTWDAAFSAKALKGYEGALVNNMEIMLRQLAKRANADEAVDIDDWGMFFAFDMISEVGFGRNLGLLEQGKLSPILEQLEDLMKFQQVVNNRPYMIEVTRQIPTPKGAYAGMVMELLEQRDKDAHGQKADIMQFLYEASAEEESTDKTDSTTYDKYNMRNNHGRRAELAAEARLIIVAGSDTSSTVMAMTLFLLLQHPEVTAQLRAELDRVFGTDYETAVSDFARLDRECALLNAVINESMRLFPPLAGGLQKVNTRDSTVVPLLSGSKMVMPKDVVITIPTWTMQRDARNFSPEPNAFRPERWLQPDKEERFDRRAFVPFSAGATVCVGKLLAYMELRLVIANLVRRFDMRATSDFDPVAFEDGLRDVFVSTRLKKLSVRLADRSSGASQAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKF4</accession>
    <name>W3VKF4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKF4"/>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000080">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="123"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="341" mass="39305" checksum="584BFC6B1FBBAD48" modified="2014-03-19" version="1">MADNTTPEVDLDNVIDRLLEVRGSRPGKPVHLEEYEIKYLCLKARDIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDDINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLQSMEQIRRVMRPTDVPDTGLLCDLLWSDPDKDISGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLLCSFQILKPAEKKQKYAYGGINMGRPVTPPRKQKKKSDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKK9</accession>
    <name>W3VKK9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_05237</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKK9"/>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_1"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="144"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="274"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="290"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="361"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="452" mass="51502" checksum="D3AA271AAF4C20FF" modified="2014-03-19" version="1">MIDLLLLQPDKGGNPQLVKDSQKKRNASEELVDEVLALYKNWVTLQKDLDVARRDVNAVQAEITKLRKAKENADEQMAKKKELDARVNQLKPSVVQAENEMKSKAMQIGNIVGDKVPISNTEDDNAEIRKWHPDGPNAQVEKKDGILSHHEVMYRLELFDTERGTKISGHRGFFLTGDGVDLNQALINYGLDFLRRKSYKKIMTPFMMRKEVMAKTAQLDQFDEELYKVTGDEDDKYLIATSEQPISALHSDEVFTEPAKQLPIRYAGYSTCFRKEAGSHGKDTWGIFRVHQFEKVEQFCITDPASSWEMLEQMLANSEEFYQSLQLPYHVVAIVSGALNNAAAAKYDLEAWFPFQGEYKELVSCSNCTDYQSRRLDVRCGFKKPGDTKPTFVHMLNGTLCATERALCCVVENWQTPDGLKIPPPLQPYMGGRDFLPYLRELPKNTTSQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKQ3</accession>
    <name>W3VKQ3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteophosphoglycan ppg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKQ3"/>
    <dbReference type="HOGENOM" id="CLU_095754_0_0_1"/>
    <dbReference type="OrthoDB" id="2553651at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47162">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="290" mass="31098" checksum="E802E8226CABF9AC" modified="2014-03-19" version="1">MSSYADIAAENAPPKSQQPQPDQGYLEGHNESSSGPNPNAPDVNSGKVNVVPSDSDLEHLKTQSQEAYDEAVAKAREQRKQLEQDAQKASNAAKKTANDAHKAGKDAAEDAKKAGKDAADDAKKAGKELADDAKKTGKQVADDAEKLGKEARAEADKFGKNARAEAEKAGKKAGELYEKGKKELSKDTEALRKRGEEGAKKLKKKAGEAEKELESWWNQFSRDPKQWVPALAAANVALLGGLGIYAYSNRDNVQRTDRRLISAATVGILGLLGAQGYWANETAKKQNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKT2</accession>
    <name>W3VKT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKT2"/>
    <dbReference type="HOGENOM" id="CLU_456437_0_0_1"/>
    <dbReference type="OrthoDB" id="2554683at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.75.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="594" mass="66752" checksum="B9D531CA95589DEE" modified="2014-03-19" version="1">MTSKDLPKSSAPDPWPQEPRSDGALYGDLPIEVPRATETNTHITIHDRKDGVTYFRARQANKQHIVEGKIDTAYERFIFNVTLYQVKGQDRMRIGSMDLGRAVALQGPLPSDPSRVFADHADGDALNNTAANLHWVTPSFNNFNRKKKRDSNGFVRVKKRGNRFTPEVAGIGQGSYHCAETAALAYNLVCRHLFGDQLDKTPHLLNAVPNENTRSSQVAVMPTGAIIHRIDGIFVIFYHERIQPDSKHATLQAAQDAAKKLVADLDAKKIQAEADWKEKEKKLKVTDREDDAAFIATSSGARVLVSDDTWKKTKSLSRWIMGAGPCDVVDHINQDPLDNRLGNLRLTNHSANAQNIRRTRGFIGVGQDHGAADWTVHVTVRGAGRIATKKFSDLQKAIELYDLAALYQHGRGALMNEPQRMQEYLNMLETDATRTMVKDFLERIPSRRRFYLGVEQTGPEKFLGTCCVGKGRGRKTTHCTFDGIGAEVKAAVYWDVWRLKTKGKEFTVNFEFMRPWYLHYVDSLCPENEASIIDLAYDRMGGDDFKDIRKRQPYTQGQERNGEASGSKSLGKRLHTATTQLTGGSQTPRAWQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL75</accession>
    <name>W3VL75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL75"/>
    <dbReference type="HOGENOM" id="CLU_038404_1_0_1"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833289" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="177"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="451" mass="48310" checksum="3C7A3D0D47AB9F8D" modified="2014-03-19" version="1">MLAAWCVLLMASLISAQSSSSSSSSSLFSDSRCNSNLCLSVIYSPSQKVYNMTMSTDGGGAPNGWYAVGTGNKMKGSNMMIGWVDTTGNVVMSQRTASGHDDPVTTITAAAATMHTKQSFSNSSGTSTSFIWALNKNNNPASSTSAHLKQHSDYGTFSLDLTKPYTPSTSSSSSSSASGSNSNGTPLTPSTGANNQATSTRVLNTSNKLIIAHMIMMILGWFILVPAGILVGRFGRTLFTWFPVHRGLQIAAFVVVLIAFILIVVEVGRGGDGHFESTHGKAGLAIFILMIVQIALGAAGHKTKRFNVSRIVHVVLGLGVTGAAIWNSTEGLSLWDWGPPRWAKWILWIWAAVLAVAYLAGLALLPRDLRQWRQSQPGAEEKQTYTGLEPYHSGGAYDSPADSSQLHLSEQHALQQQQPYQANAHPGWGAQPLQTNNAQYGYEAYAQPYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL77</accession>
    <name>W3VL77_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL77"/>
    <dbReference type="HOGENOM" id="CLU_055322_0_0_1"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014063">
        <property type="entry name" value="Arsenate-R_ArsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43590:SF1">
        <property type="entry name" value="ARSENIC RESISTANCE PROTEIN ARSH (AFU_ORTHOLOGUE AFUA_5G15030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="60"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="288" mass="32438" checksum="0A7E8F5E55B72DC2" modified="2014-03-19" version="1">MVSPSELSSASASAYTPFLDPAFYTGDVSDDWTYKIARQDQLDQLSEARQMHQALPRPLRVLVLYGSNRQRSFSKLMSFEAARILHHLGCEVRVFDPHGLPLKDDDDAVRPFLSPTSDGQTAGTDAHPKVQELRQLVTWSEAHFWCSPEQHGNLTGIMKTMIDHIPLSLGSVRPTQGKILAVSQVNGGSQSFNAVNSLRILGRWMRMFTIPNQASLPKAWTQFTPEGRMMDSSNRERLVDVVEELVKVSCLFYGREETFASRWSERKEKAQVGRLLSQAEKEQAKDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL88</accession>
    <name>W3VL88_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kri1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL88"/>
    <dbReference type="HOGENOM" id="CLU_009647_2_0_1"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="622"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="742" mass="82385" checksum="82221D7611036496" modified="2014-03-19" version="1">MDLFADAGDSSGAQVDIRTKPEESLNHFTVNKDFAERYLHNKQRAELHQLEAKYGKDALSDGSDDDSETDSESDVTEDEDGDQINANVDAAIFRTLQRIRNKDAALYDSKTDIFEQEAKAAEEAARRSGAAASTSKVSSTTKKSKKLTLQDYQRQRVQELIETSENPAEALADATTSDRVKGLQDEDDDDKMPFAQEQEELRKQVSQAFHANVDEADDLFVKRSEAEGSNGGSYRDAVIASLGPDASEDMVREAIRRNRETESSEAVASTSTDPNEQKANEDFLLNYILNRGWIDKSAEERPAKPRLSKSLLKSKSTDATGDDKQDDDEAAGEVATSSNAYGRDWEAEAAELESEASFDSMADAFETAYNFRFEQGAESLTIPTYSRTPKDSARRTDNTRKRKREERAERKEEEKRQKMQELARLKNLKRQEIVDKLKKLREVTGSSVEDLQGLDLEGDFDPDAHDKAMQKAFGDGYYEGEDGDEKPTWDDDIDIDDIIEEHEAATAPTKKGKKAKPAHDADEDDEGRIEMDADFLDGDDGGEQGAAGSKEAAIRARLADKKLSKKDRKKLKKKLKAALSKGSSAPADGSDSEADGVDESIMDADRAGSSSMPTSAEDKKKMAKDMIDSYYNLDYEDMIGDLPTRFKYAQVAPADYGMSAVDILLADDEQLNQVVGLKNLQPYRRGKNRPIDLGKRLGTFRKEVYGNTSKTPDGADKPQKKRLGKKERNRLKAAESEPSKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLH3</accession>
    <name>W3VLH3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vps41 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001285_2_0_1"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000932">
        <property type="entry name" value="Related to Vacuolar assembly protein VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000350">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="293"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="927"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1306" mass="143899" checksum="BCA3212EA575F6A9" modified="2014-03-19" version="1">MSSPQETVKLADEIRQRQASFATRGFGRRNRPTLHSEPSVQLSTSHDDAGPSDSARDASHELGSDSPQQQSVTLADDDDEEAGQLEMDYAPDEEPSPTLADDSQAPERPDGQSQNEDDGPSLAAEILAAAASSDAISPKKRTHRRRPDSLRRTESSSSAGRASTSSLDSTPTSPAPRRKRPSLGRAESAAGSSHDDAVKKRMTVLLEGEMPEADAVVSVDENAKKGAGRTRSHSQEDMDRNGGQASSDVEGTQQATDTEHDETFEDEAADEDEDDESADESDEDEEEDVEPSLKYSRVKGGVSDVLKRDTASAFALSPRFMALGTHAGMIYILDINGNLVKGFRLHTASILDVVIDNTSDFVAAASMDGLVSISALATAEQYVFDFKRPMRCISLEPNFGRKSSRAFVCGGMAGSLTHREKSWFGHKETVLHSGEGPIWTTRWRGSMIAWASDKGVRVYDTDAKQRISFISPPSKDVRGDLHRCTLYWQDDRTLLIAWADHIKVAKIKERQANGSAGGATVSSGASIASTSTHNAASALSKVGVPGTGPSHPQHYIEITAIFQLDCMISGIAPYGLDYLVLAYVTDEPDDSDDDRDDEQQGARRRPEAQRPELRIISRAGEELSSDVLSLNDYSRFQCNNYLLVPSIEAHAYSAALLAGRKVRAESTEASQFYVVSPRDIVVSKPRDEKDHVEWLLERQRFQEALIKIEGMGKTAALQNGFDAEVIGKKYLNWLVEEDRYSEAARVASKILGRNASAWEDWIFLFVEKGKLGLAIPYIPTSDPTLSEMVYDMILAHFLQHDLDKLLETIKEWPSEIYSTPAVVLAIEDRLASSGGGGDGADDDKVKTATERLLMECLAELYIKNRQPGKALQYYLRLRRANVFDLIRDNNLFTAVQDQALLLIEFEEDLKTRRAADSSSHSKHGAAIDLLVDHTYSIPIGRVIAQLETHPRFLYMYLDALFDRDPQQVTQFCDLQVKLYAEYECGRLMSYLRAMSSFYSFEKAYAICSEHDYVAEMVFLLGRVGDNKRALSLIIERLGDVERAIDFAKEQNDDDLWEDLLGYSESRPAFIRGLLENVGAEIDPIRLIRRIKNGLEIPGLKAALIKILSDFTLQISLLEGCEAILSHDTKVLSEELQRSQLYASYVDDESICASCGAALFASGLSKTTGGDAYTAARQPKVVVYLCGHVHHLTCLLPPANVPAVKSAVTGAESVKLTTTQAFASTPAVRQRWTSHAWRSFDAEEDEAVAKQAVPASLVELSQYGPLHRANHATAQFHARLKYEARLRSTIVAKKGCPTCISEGLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLH9</accession>
    <name>W3VLH9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244510_0_0_1"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="880"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="947"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1108"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1450"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="640"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1485"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1498" mass="161767" checksum="22CD1D7F1B61517B" modified="2014-03-19" version="1">MSAQKDFILFDDPAPSAARADSFRPLPSATAQLPPPSSFTKHRSPRQSPAFDDGAPPAPDALNDAAGPRRKRQRSDAFAHPPNSTTSHHALAPNQRISPPSGSLGAPMHDLSLGDSLPLYDRTASSSALPSPASTAAMSREQQERVKAQIRAELAGVDTRAFKGPLRDILQKQDYTPSHNDMQTSPLSASSDPMQAGVAPSFSLFPDYDIGGSRSRSHSTHNGRATPQENPNAADQDMPPLLSQRSSDMRTKSGNIDQGFGPMSYPPARHSQNILPDWARQSHSTQISREQHSQFSQQRPYMPPPALSQSLLAQRGGPVSMPSTEPALSANYAEPRRPLKRESSGLTVSPQEAFLDYDHVENHLSHSGLGKMPSLFASVPPGLSDAKLAPMRASAGAQTPRMPSQHNAPRARSSTDEAVYAARPVAMTRNDTARPHHYQKRPGPSVHQSPAGRSPYLNQSDGRGSASQESGSQSSLFSPVDSGDTISTDDDEDERPYYPPNMRPSMIRGGPSSLYLNYPRPYYPPNMRPSMIRGGPSSLYLNYPVKGDGRSSHSPSMLTRPLLGKERTSSSGSGAWSHVRTEPWALRQAHMNQPRFSDVSASSSDSDDDRYGRRGLQHRQGADYHPRHAAHHQPHPHHAYPPYGRAHPHSTSPHAHSANHDARNAHRPSLGQHQSSSEDMDDTDRYGRRASGRMDERPSRAHVPGALGGYGYIPGSQESGLSVPGGGIARSQDDGSISPSIRSSAQTIDHRGRYEAPAPEISAPPPLLTSRQPSGGAPIPAATANVTAIPTALPPPGALGPGSAGVPLRDERMEASGGDESSSTGTNSASGGGNESDYEDGSPDSAASKRSVARKDKGGTTTTTLAAAKALTSVATDGTTKCDYISPITGAECQTAFHRPYDLARHRETIHAREEAGFVRDGKLSLDACVVLGKEVDPKKSTAVVEWKCKECGANFSRKDAMLRHERLRHNAANIHWLMYFGKVTFEFRRVRQSYDQQLQTLAQADAEAKVQARALARARKLARARAQAEAQAKAEAQARAEAQAQAHLNGQQHVQQAESHNAPSPAPQQAAVHRQAVSPVKHGETTQARQPPAAVTDEVLPVAKHRPAEPAPTAAVARSEPVPSAVGTPPAGITSHKASTQRRSASPAVASDAGSARADDGERDGASVAAEEAGEDSSERDVDDGSDAADVHADYERLMRKDEETTRVQGDAEDHDDYDMATIEHTLIYPPDGKVSIPFPPSELTDPLVAGMVPGSRRWRFEALPTVADEGKLISKIINMLLEDKFDLQECSISLPPAPGRERFVQIHFNVLADYVQAATLELTWNGRPMELVRSAAPLRKRSTVLKIYNISGPTAETIDNISSAIGDFVSIDNIWRLDRVVYINKSQSTITVKGSTLLILATFREHPAVGWYGPQDLPGFVATRSSTHALHFIGRTNRCGCRLPERNSPLNCVGSTDHPGMQRKRTRDDAASFPHPVQKKHKKDDTGKKQVDQPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLI6</accession>
    <name>W3VLI6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLI6"/>
    <dbReference type="HOGENOM" id="CLU_009538_1_0_1"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="752"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="923" mass="99019" checksum="FE9F0B1E4733B5B1" modified="2014-03-19" version="1">MDSIPADKWVGEYARWLRVHEAKLGDAAASAAAAKRNAAAAKSASDASASTLSSTFWNVNPHNLYYLLIRFEALGLPVGSLDTNIPVAARPTSYFSFVAANASGKDRDDTMSISSMASRISVVSSSFSSSLSWFGGSTARADPSSDIKYIYSCFTKIPSLRLGPIPARRLIQDFEDCPGQSAVPLDVFKNLHLLELDDVDPRTLLGWDRLCIQLRSLSCKKSNIEDLTDLLVDLVILDTRRRRGERVDPKRLRRFDPPPAESETDAAPSLPKDMPSLAWHFLRHLNLSSNNLTFVPVEPLLALSALTHLDLSSNLLNVVPPSLSHLPALVSLNISDNLIDSVLGIYDALPVVRVLNLAKNRLESLCGLERLYALQRVDLRANAIFEAGEVGRLAPLPAIAEVWVKDNPLVEELVDYRVDCFAEFAREGRTIALDGEAPGFFERQRIAERVGSSTNGAATAARTTSTSEHEENEAQVAQDAATTSRLVTVVKNVRHRAASRPAADAARGRGEHLDLPGQSQAKASSGSRSRSNSRSRRDGAGRRRNQRVVELDSSPQKPVTEQRRERTLTDSDRIKHAALAGDTSAAMDSADAARTSDAATNGGPHSSSDALAAHGAMLFALPPGMAPSEQHEPGKAKPRTLTSRRNPIDSSTLGRKSAARPVASDLFATSDSATNKAGATGEVSESANAGAAQEQVDDSPAVLARQRIARPRTGSAAALARRSRVTTSMYDPDLSVAESAMSLNAAPLTELTEEGAPSAAATASEAAKPVVATSPGATGKERTDALRRRIEALKSEVGDDWLRLLARGGGATGKERTDALRRRIEALKSEVGDDWLRLLARGGGTAGERNSVLMLSNVNDESTPSTAEAEAEAVNVVRPKRTKPSKKKVRNGEESALSGRRSTEQAHADSSTPVTRLREARIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLP6</accession>
    <name>W3VLP6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLP6"/>
    <dbReference type="HOGENOM" id="CLU_119261_1_0_1"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="154" mass="16563" checksum="0099CEBF3974594E" modified="2014-03-19" version="1">MSSSAPASAPAPVPLVMQLIVDGASSTSFGWPKGPWMAQSAHAAIAAIQTSLDSAATREYVSSANLESMHKVTLQTPAEGKAKMTLPQLSEKLTAARAEWEKTRNAASEDADEFPRHFLWIEQPENVPTCLAIAPNRKPAALKKVLRPCTLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM80</accession>
    <name>W3VM80_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM80"/>
    <dbReference type="HOGENOM" id="CLU_007383_19_0_1"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="341" mass="37084" checksum="4C96776E6321D2B6" modified="2014-03-19" version="1">MTIQEQTILITGAGGWLGSLLPARIVQREPQTAFSFILADIVEPKPAKGLAAKVICKKADLSEEASLDELFNTEFGKPDVIYSMHGIMSLGSEENWDLGMKVNLDSTRSLLEKARASRNSQGGPIKVVFTSSVATYGGPLPHVVLPSTPCQPEGAYGTAKLMGEYLITEYTRRGFIEGISVKLPTIVPRPGVPSRATSAFVSGIVREPLNGVEAICPVGSSIDDPVLKKLEVWVAKPSTTLENLARAKNVVTDSANKITRWSRSVQLPGFTVSILEIIEALRSVRGDEAVNLIKFEHDDTCQRIVSSWPREFDNSYALDLGFTVDQDGFTGAIKEYMDAHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMB5</accession>
    <name>W3VMB5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMB5"/>
    <dbReference type="HOGENOM" id="CLU_026591_1_0_1"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="8">
        <location>
            <begin position="294"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="572" mass="64058" checksum="E348C7FF896FFF17" modified="2014-03-19" version="1">MSAAMSPEATEERKQRAPAATEETRRLLGPALSGKHADLTEHLRKRQVADLAKISESGTGILGWFSTTLSDLYTYLFVWFPRTWWITLTSLPGYLLDPLGLGTTLIFAFGTTIILLIGLTISAIWRLPIVQSYWRPYSNKKDIGLANMFYPLIFEFGADPQNKLIRDAAFTVMSDPTGTYAQPSSDQQRSFDLEICKILMMLSALVYERDVGAYHEAAMSAHKAKKLKKSLLMGSDTLTDAGKDAYKKLATADRKIIKVAKEWGLNYVSVSELATNTSPLCGAFWNPDYNFLILAFKGTNPVEFKEWAIDMTFDYVDGRGWLPGYTKAHAGFYNQLFPQSLNKKTGAFPYSQIRASVADIVRQIRATTGKDHVNLYVTGHSLGAALACVFYSRAIASPKDYGLNEQGTNQVYVRDAYTFGTPIVGDPDCISAFNQACHDRDLDHPQALWRVTSRRDSIATMMPDAGDFNTLKHISPTSQLHFAHIGQEVQLSNDIRKVYTGPGTALPKQTPVNIVTHLDRGGVGPEVNLPGYFWFLERTPVINRMIAHLPASYWDRLSKVRSEYDIEYIDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMD5</accession>
    <name>W3VMD5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02541</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMD5"/>
    <dbReference type="HOGENOM" id="CLU_023334_3_1_1"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="432" mass="46811" checksum="A8854DEA7B922C71" modified="2014-03-19" version="1">MKITSRHIEKDGSGRVTMVPEEDEDMYHLYNLIEQGDRVRAAAVRRVQSESSTGSIESHRVRLNLTIQVVKTTFDATGSSAPPDPSAASAAAAASSSTPADEEVSRAAAVGGSGGEGATLQVAGRVVEENAHVKMGAYHTLDLEINRALTITKESWDAVHLERLGESTDVSQRAEVGAVVLGDGTAAVCLLTGHMTVVRQRIDVPIPRKRKGLPATAADKATARFYVQVYNAVVKLLSLPALRLVILASPGFTRDSVYDFLFEEATRRGDKILIGGEARRKFLKIHCSSPHVHSLMEVLRSPEVNAQLKDTKFAREGQLLERFMKQLASDELRAWYGEKHVLLAAARGAIGVLLISDGLFRAADPARRKRFVELVEEVRAQGGEVAIFSSMHESGRQLNALTGIAAILTYPLDIEVVEAEEAEDTNQPNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMF4</accession>
    <name>W3VMF4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMF4"/>
    <dbReference type="HOGENOM" id="CLU_1594302_0_0_1"/>
    <dbReference type="OrthoDB" id="5201563at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="167" mass="17824" checksum="D4D0BFB417AAA2E7" modified="2014-03-19" version="1">MAAAAVAPRPSSTTTTTTMTGMTSEGSRTLLEIQDHARLIDHHAAHTSGGAGTGSFSGSSTARAPAAGLWTAPEPAHGVRGGDTSAQWTNPASWPEQRGTPAYRPIDRNLDHSRRPWANTVPETIFTVTMIGLGVQTIGLANTIFRNTVGKVESVNRFFRYQCPHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMJ9</accession>
    <name>W3VMJ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_03583</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMJ9"/>
    <dbReference type="HOGENOM" id="CLU_002572_0_1_1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000014">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="794"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="137"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="14">
        <location>
            <begin position="884"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS62027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="946" mass="106461" checksum="C415E7568FC3CAA2" modified="2014-03-19" version="1">MSVKNAHDPFATPLETIHHDPLAETAGLKADYDKRAYGEANPGLVGTLEKDDIANRPIDAVEEVPTTSVRKWWVRLTWFTTWWIPSFALAKCGGMKRPDVQMAWREKFTICAIIFWLCAIILFYIIGFGRLLCPDYDKAWNESQLSQHAGQDDYYAAIRGTVYDFTKFYKGDHSDITNLQTSSDLMLQLAGQDLTEYFPVPLTVGCQSLVSDTSLALQPTANNTPAISQAVHTSGPLQSDASSKLHDIQWYPERFLPFTKKLKKGYYVYSKKSIEDQGQWRNWAVVNSKVYDISDYLNTLNVYQTNAAYDFLDSSLVALFKSQAGQDITADFTEVMAGFNTTYRGATQACLDNVFYVGKTDFRNTARCEVQNYLLLGFSVLLVATVLAKFIAALQLGTKRTPEQQDKFVICQVPCYTESEEELRKTIDSLAGLEYDDKRKLLFLICDGMIVGSGNDRSTPRIVLDILGVDPKIDPEPLMFKSVAEGSKQLNYAKVYSGLYEFEGHVVPYIVVVKVGRPSERSRPGNRGKRDSQILLMRYLNRVHFDAPMFPLELEMYHQMKNVIGIDPAFYEYILMVDADTRVEADGLNRLVANCADDSRIIAICGETTLDNAEGSWWTMIQVYEYYISHHLAKAFESLFGSVTCLPGCFSLYRIRSSDKGRPLFISNRIIDDYSENRVDTLHKKNLLHLGEDRYLTTLVLKNFPAFRTKFVADAKALTSAPERFGVLLSQRRRWINSTVHNLAELVLMPELCGFCLFSMRFIVFIDLLGTVILPATAVYLVYLIITVATRTAAIPYISIAMIAAVYGLQAILFLLKRQWQYIGWLIIYILAYPHQQQQHQQPPQSPPQQQDVRPVSTYSTLNAANPFAAAHVPRALAVNEASDPTDEEIRAAVQTYLASQASLMSVTKRSVREALVAAFPNAELSSKKQMINKAIDATLSGGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VML7</accession>
    <name>W3VML7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thiamine-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VML7"/>
    <dbReference type="HOGENOM" id="CLU_137479_0_1_1"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="3">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="121" mass="13512" checksum="BBD88D1884143472" modified="2014-03-19" version="1">MSPPLSTQPLYAVADFCLIPMGTPTTSVGEYITECQRVLEEMKDEGIRYEVHGYGTNLEGLFPVVSKAIERCHEAVHRLGAQRIATDVRIGTRTDKPPPTSQGPTENQRKKQSVLNRLMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMR8</accession>
    <name>W3VMR8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMR8"/>
    <dbReference type="HOGENOM" id="CLU_038704_1_1_1"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="372" mass="39736" checksum="56F41E66268CA122" modified="2014-03-19" version="1">MSFGFQFDDSELDDEYVSLASAPAPTATPSTSNGDSSSVPQAPYQSYSLDDMLDHLPSRISYSSISIPLASRGTSVQMLRRDLFDARFQMLLDEDEDDKTSNAAGMDAQVDAQSDLIPGVYEGGLKTWECALDLVETLDGLHSGRWSEHFSGKYILELGCGTALPSLFMLTQVLNDRAGVGMTLNLADYNAQVLQLVTLPNVLLAWWSSAAAAAFRAGAGAQQTALERHELARRGQDHFDTAPHDVDGHGELAITPELVSAFRTSLAAHGVQVNFIAGAWTNFPPPARGMDLILTSETVYALPSLSPLVRLLHTYAAADAAVLVAAKVIYFGVGGGVEAFKQTLAQLAPSAQVASIHTVTRGVGRTVLSVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN19</accession>
    <name>W3VN19_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Proteasome activator subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02652</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000772_3_0_1"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="12">
        <location>
            <begin position="468"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1450"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="1868"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="11">
        <location>
            <begin position="1933"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="660"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2019" mass="225381" checksum="F90DACC0524971F8" modified="2014-03-19" version="1">MDDDDILEVDSPMEPAVDLDEDEDEEMPALSLDGAASQPAKKPRTENRHLQLDYPQSLPYVCETLDEFDARLDHIIRRLVDCVRAKDYDIGLVQWNHRLQCLLSLKYPLLRKTRARLARFYYHLAVLPGLNTRCIELAANMCITLIENKKKCDIRDLVLPWKPLYAILEKELFPKRRRTGLTNISDVLLDLAETAQRFFPASDADDMLRTFLPKMDGSNLNSVIATQAFLVHFLPISHPQRWLPAMFRLWESFNSSLFDDQMLDLLARLAEMHVTDPSISSTSAARKASLLAESTLHPEAQTVSNTPANGDSQAEASTNNGEATKSPDPGSSTPPSGTESPAASVGLFSDIGIFTEQQFSLIMTKCLKSAGLPVGSSKAANAALMAQSASVRSGPDAAASGATLKMKKPTDRLRSFAVIIAYSISKDGPSPAEAASASYVPTPTGASSPGAAKPVTTYPAGSKALDHLAKFVQATESYFHPSNWGLWQISLSNLVQQIMFEFLKRAKEEERPQCKTPHQYRLTDDIKTEIVSILRTVCLLSMFSKGPLAIASSQASLKRMAILAPELVIPAVLDRAFNSLEALETTHRTNAVITALSTLAPVFTSRQLDRSGGKHLLPLLQLCIPGIDLNDPMKTMSTCMFVLLSTLSLRIDDLTRPETYADDHETIEPLPDQPTLGPARREAVTGSLEDAEPASPQQEDDQLRISTAEFDPWLSAFFQRVLSLFETLPEEGKGGRTGGKAEEQVINMVMAASDGLCRAMSPYLLEKSFAKIADYCANTVSATSVRVIGSLVGCFARADGRMVLKRLLPQCIANIRAEIANGASSTRTTSTSLPASSDATLHWNLSVLTGAVTGPGDHLLEFKDDLIGVLRLVVEHCKSERGYSFGAKLVQKMIASLTSLYPSEQRFVNQEIWEGDDFARHSHLFWGKMYDEKAVKMNWHVPTQPEIDMALELVDELVLPALFKVEALQAEGQTRDKAWSNDFCRYLMVVRMGLIGMPTLIQEDDVGGGEPLMDLGDEVPEFIAIPPRFKSFFCLTDRQDARYQKVAAFKQRCGQVLHLSAKSTQASGAEDQIDCVKMLIRTIRSYLTCYSYNGEDYKAHMRSLGFFRNIAKLHAKQKEFPRVLFIRRSAFYNTSRARLNSFHRKRTPLTDQLILQMLDFCMSNYVGIRQTAQNTLDTIGGVYDGTWILCLPKLIEAIQPGVPDDRMKGALYVLGSKGASYLCITDARFSTEYIMSLLSAQHHSKPSIQKLVRGIINDFIIRFAEPSTLTNKVDSSALDEAANALERALPLHLRAPDADLVQAVAAKRALRLERVDQMHKELTGKALEFASSETTHWAFSIFAARLLRALVRKDRPMDEGAAKYLAEQTISENPKMRHCAQAAITKVLYYVKLRTLAPTDEDLLLGQTNNPLKHSEKLPTPVSAEWTQQYIASFAEPLTPTSKLRDKPSQGWLVWGEEENFYDPPPAEGTVFDWDSASQPAVEAVRAAITQDSWWQSFCRHLSQERERDYPGSDSVNLIKSMFQIYGVDLLPFVQTTVEQFIAEKDRHRHRAASELICGIYRGSKHWNMKDQATLWTWLETLLPKIFDGCTPDSQPAWQSCIEYMLQARDPRRARPLVMYIVQAARDNIGKENSNASPWEQAKAQNLLRGALISMNLQFAPFGADEFIRIYSENFDNHFQEVRSVISESLADLELLQVNPSFGNVEMMLDVCSSGQGSLLSRPELYNGRLETLSQQLKQWRTERKPTAEGTSQYDRAATTALLWISTTMGDHRNSALAGEVIKYIPDIFAMLELHDNKELSALARAVLTKISTYPFTSEYAGRLIDTVLQVTRSSVDSWRARLDSLPVLQVIYFQNLFYLNETLVQSIVELLLELLSDRHLEVREMAADTLSGIVRCSQRRLIKTLKNRFTKTVATTVVPKRGQPGYDQQLLALHSGILGASALLAAFPYEVPDWMPSLIVETVAQHTDDAVPISTTVRKCAADFKRTHQDTWSEDQHKFGDLLPEVNDFTLGRSDYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNA8</accession>
    <name>W3VNA8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sodium/nucleoside cotransporter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNA8"/>
    <dbReference type="HOGENOM" id="CLU_016813_1_1_1"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="200"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="284"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="384"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="64860" checksum="20CC0ACABC227ECF" modified="2014-03-19" version="1">MSAGAPNSQTPQLAKDAAVAEEHVATSNEGSHHEINDEKLGYQASDRDIESHNGRPPVEAIEPHPQGEPGRASKLWHSIRTHKATRIAFDFALIGLILGWWLPGIIREETRHRWVITTIWSWFFILLILFHNDRYIPKAPFANAIGAAWTTGVSRPWGMIPHYGQIGLGWLALLALYFGSAFGIKEVPESRYGDRARSLFGLFLINCFFYCISTRRAAIKLQPVMTGLGLQMIIGLLVFKTGAFFSVARWLAFAAADLLAQGQVGGAAFFWGDLAGQHYFFIDTLSSIIFFVALVVLLSYLGIMSWAIRKFAWFFFKLMGISGAEAVVAAASPFIGQGENAVLVQSFLDLMTNAEIFQVLTSGFSTIAGSVFLAYVQMGVSPTHLITAAVMSIPASIAASKMVVPETETPVTAGSVNIQLNEKADAVDPLHAFSNGAWLGVRVAALIFCNVLCIVSLLYTVNGLLTYIGNFWTINNLTLTLILGYILYPFCWCMGVPKKELLRVSELLATKIVANEFVAYANLAKIKVSANPLSDRSVLISNFMLAGFGNIGSLGINIGVLSGLAPSRGGAIARLAPLSLATGILVTCSSACIAGILGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNG6</accession>
    <name>W3VNG6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNG6"/>
    <dbReference type="HOGENOM" id="CLU_537669_0_0_1"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833253" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="356"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="528" mass="57786" checksum="27A3EF5272FB6162" modified="2014-03-19" version="1">MSQMACVMRLALVAMLFVAVLTSSQVSADQVAHPPRHAHPGLRKSVFGRRSTMMPDPSDPDCPEGDENGPCHLQEVAQSLADKSEKAGGKEETYEAVVPTSQGDTHIDVRARSEVGKSGSHRSWSWSSSTHSSSHSSSSSSSSSSSSSSSSTSSDMPLSASHDHPSGHHAASTGEQQHNSHSDHSGHSDQGKNVPATQMEVRSPPRTRARPQEVEGKETVVHASHSRHTSDTTKSVSTSEDDGDGKVKKHKTETKTHDTSSSSSYKSFTNVFHYVISGDMQHSGNEAPFADGHIEWSHTPVDAAALAIEAQIGRPILRPARANVCNRRFPWKGKQYTAVDRDQRFDDPWPREALDEVSKAALDLHNQERARYGLVPLQWNAELANMAACWADLKAYGHSEDHYCASGENIAMGAGDTCYGNPLQGMKNAIMSFLDEDRNWAREAHLADDDGHWTQIVWKDTRFVGCAVSQRKGLAQSYSHSGGATMYVVCEYYPSGNVQGQFEHQVPRVKPLPRLRSQCSANEVHTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNS1</accession>
    <name>W3VNS1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNS1"/>
    <dbReference type="HOGENOM" id="CLU_003291_4_2_1"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="119"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="663" mass="70267" checksum="3538C04D81CDF1DF" modified="2014-03-19" version="1">MDQHGEALLAAKPARWQRLLQTRVRGVVNRALESVVESVSMRGLVAGDPHSSAGLHEQPRRVQQRRTIVSTQPRLLMLLLRQPSLLVSAARPLLSALPRTYTPKATFTSSIFKMSEQRVRVGSAKEVAQGKMKEFTFAGEGDDAVKVLVSNVKGQLHATSSKCTHYGAPLANGVLTGDGRIICPWHGACFHAKNGEIEDAPALDSLLSLKLEVEGDDLFVTADAEKLKGKPGVAPSCKGGVKSIAKGKGVVVVGGGAGAINCVEELRKSGFQGAITIVSNEQAIIDRTKLSKALIADADKVTWRSKAHLDNVLGVELENATVTAVDAKAKSVTLDNGRKLEYENLVLATGGTPKRIPIPGADLPNVLVLRQISDTKAINEAVGNEDGEASNKKNVVVIGSSFIGMEAAIALTKRANVSVVGMEKVPFERVLGEQVGGGLMKAQIKNGLKFYMEAGVERIDGESGSGPKAVVIKNSEGKEESLPADVVILGVGVAPATGYLKESGFQLEKDGGIAVDSKLRVEGHRDIFAIGDIAAAPTRASPHSRIEHWNVASNQGRAVAKTLAGTETDYDKVAIFWSALGSQLRYCGSGGPQFDTVHVDGKPEELKFSAYYAKGDEVVAVATMGVDPLMVQCSELLRIGAMPSLSDIKNGKDPLSLDLSAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNT7</accession>
    <name>W3VNT7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNT7"/>
    <dbReference type="HOGENOM" id="CLU_002540_2_1_1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="314"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="671"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1057" mass="113997" checksum="ADD249C65FB86CCE" modified="2014-03-19" version="1">MRWPASRRPCGSQTFAKTMLAPGLTASRLRSACNACCRSMQTNFPACFVGIQSLTMPSLPQTDKDALESLIDPGPRTPSARASARLTASSVTIIMFRLLLLLLLCACALANTVDLQQPLSEQQQALAPSPHSLDAIARAAAESFLEQHQAATTQDAQLDSASLDVDPVKRDASAFLDLDPAPLQLLDQQQLGPAQYMLPKVLQVTASGLTGIAEAGKNLFDGIAQVLQQSQVAWANLQNATNLTRILQDSLSDQFGDQISQAGWQLTLNDTMPPSSSSSRQNNAAQVNSTFWLELVDHNGSATYNPTPNTYKVFRDVRDFGAKGDGVTDDTDAINQAISQGNRCGQGCGSSTISPALVYFPPGIYLVSSPIVSYYYTQLVGSATDRPTLLAAPSFQGIAVIDEDPYGPDGSNWYINQNNFFRAVYNFKIDLTNMPASSGTGIHHQVSQATSLFNVHVEMRQDPDGNAQQGIFIENGSGGFMADLSFRGGRYGAYLGNQQFTVRNATFENCQTAISQAWNWGWSYHDIRISNCTLGYEMRTSPNPASGNQGAASVLAYDWTLSNVDTAFNITTPDSGTVVLDNIAIENVRAAVSAGGANAQAVLLDGSQERSVIKSWVQGAVVQGQQQLDQAQTISDIDIQRPSSLVDASKPSQPFFSRSRPQYQGAAASDFVNVKELGCAGDGTTDDSKALQQILDSSAGSKIVYVPHGTYYLESTVTLPPGTRMVGEVWPVLMGGGPLFQNGSDPQPVIRVGSPGDSGVIEISDMVFSTRGPAAGAIVVEWNIRELDGQQGSAAVWDSHIRVGGFAGTNLEADKCAREQPLSEQCRASFINLHLTANSSAYIENMWVWTADHDLDYGERAQVNLLSGRGILVESKQGPVWMYGGASEHSVLYQYNIVDASNIFISLAQTETAYFQGAGRAVASAEEPLSLQRYQDPNFNLSSAQSPTSPFANTSDPYENRGLGMRIANSTNTLVYGAGLYSFFDNYNQAQVSNRRSQKRILWLENVDSQANVWVLNLNTVGVEKMVTVDAIDTVDEGPLRNGFGNTLAVWAAQIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNV2</accession>
    <name>W3VNV2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNV2"/>
    <dbReference type="HOGENOM" id="CLU_032237_0_0_1"/>
    <dbReference type="OrthoDB" id="2548644at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="597" mass="64804" checksum="681EE736CB09FA21" modified="2014-03-19" version="1">MCHHHACATGSADGVQTVLSPNPHSKSGQDGDGLFQCSYSRAERRSGLTQTHTGEAMEAAMLPRTLLHKPTTPPNAPIGSCSSGVKCLFNPFDQGRTMRYTISRLVWAYRRLEPAAVPPDALLPASLCERTFPCPSAYLWGIDSLVESPPLSCQTGASAVSTLLSFHHSDWGIRMHRHDGSEYLPAVLGSQPHGSQVIALMRFSQEAMTWNLPVLIAQTLLVAEIVRTYPAEVRMLMRIVRRGRPNVAEIFFMVIKYLALIAVILDILVSDTFAATTDFACRSWAWTSSTFYFVCSTLVFCVIGWRARIIFRTSQKATYLISGGLVVQLAISMWTNWRVVKADALTVAGTCAPAAQVHAGPDGNGALRIHFWQSSTFWFLLYNTLFETALLATCSLRLYKTSSGPAGLTRIAKMLFVNNVHYMAGVETCNLIELIMLLGWASSLPAVHMTSIAIQIVVGLQMLIGEQEAVHSPSCSRVGYSVANSTTSSYAKPTATTATSDASYSGHVRALSYIKRPATAGSAREPAYIQHRGRGRKGTLSSISSVPRYAKPIPEENVPGMPQRAATAPDNGVQVSIEMPPLAHASSAPNGSAYHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPQ9</accession>
    <name>W3VPQ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_02470</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPQ9"/>
    <dbReference type="HOGENOM" id="CLU_015631_3_1_1"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS62732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="530" mass="60737" checksum="7ACF001552C0C64D" modified="2014-03-19" version="1">MADSAGLRTRSAAAKASATPNGKSKPTPKKRTVVQDESDDDKANYTPKHSYLHVDLNDDQIMGGGKQQTLVKYTPGIVISEQGRETDKKLDEHSDWEFGGPWGVTAMMTLFPLLMYYLWICLWFYDGKLVVPNSLDDIWPFVQRMGAHVRDDAFPTKRAFAGYGGLMVFQFLLAVVMPGYMQEGLPVPSLGYKTLMYKCNALSSFYATLVTCAVLHVSGVYRLTTIIEHFGEYMTVSMIAGYAVSAATYFHAVATNTTHRMSGNFAYDFFMGAALNPRIGSVDLKMWAEVRIPWVLLFLISVSGACKQYEVYGYVTPNMAFMVLATGLYINACGKGEECIPQTWDMFHEKWGFMVIFWNFAGVPFTYCYSIVYMAAHPPSYYKFSTPTYVFMFSLLLFAHYVFDSSMAQKSRFRMQLQGTFKHRWTFPQWPWSTLKDPRYLQTEHGNALLIDGWWQFLRKPNYTADWTQAFLWGAIAGTRSIIPYYYSVFFLAVLTHRCGRDFERCGRKYGKDWEKYCTIVKYAFIPFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ08</accession>
    <name>W3VQ08_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ08"/>
    <dbReference type="HOGENOM" id="CLU_520855_0_0_1"/>
    <dbReference type="OrthoDB" id="2550826at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="489" mass="52256" checksum="E4C7C92227DF0F13" modified="2014-03-19" version="1">MSSSSPRKNLDQGISASRAGGAQKRPPATSKASTPVKKQRANPRPSPSVGSASRRSGDDSATDTASVASKVRRRVREAGGEEETKWAQSERLLLDRTLRLHTLSPLHLSSLPASAQEVSRPLFQLLRTELRNYINLRLSDGFGFLESGGTTIDARDADSGDLRPPERRRRADADRVGRVRIGFIDDAEFNTALQQKATARAWAIEIELGKPAEESESNRLGALRSKAAQEVTPAELCHIVFVPASKGHGGHSRTSHSYPLVATKAPSSSAAGADPLMAAAENVAPVVLGHALDWIQKRFDCRISAATSAASLASRLTGPRLEALAELIVRETRAATDALSADQKAADAAVKPVELVLSFPSKVKGAEPGETLPGPAPDLGSLTLTVPWEICMNFLDGLNLDEPLLPALNHYLAVHTSIPLDALELTRIGVAGINVGSGRIKIARLPVRADDAGEKSLHKRAQRANDRRRAGSVFAFLRQVVEGDVDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ28</accession>
    <name>W3VQ28_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calcipressin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ28"/>
    <dbReference type="HOGENOM" id="CLU_440885_0_0_1"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12434">
        <property type="entry name" value="RRM_RCAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="63367" checksum="18C411FF722C972B" modified="2014-03-19" version="1">MAGLEEITAPPQHVTAEQLDQLQQATPDSFASIPPVLRLRLTQSTVYLSPSPSARPSCFELLPNNKSNGNGAHEREEDEEKDEDAEVFQASGQLWLTESEVAFLSSKTNNGFKLGYPNVALHAVTRSPPSFLAAGSSSSAGFNGCLYCQLDLSPNAGAGAGQMGDDEDEDEDGEFVEMYICTPDAASLDQLFEVLSHCASLHPSGPTEDDGGHPFAGFAPFGTGASAEELEGEDDGAFDDAETNGDHEDVEGDEQGLSETGRRNLVHLESVMQWPDASETSTLVPEVGADDTASSSVAGATNTLILSSLPNEFFIPHICSLLLSLLNTYGPMVRWTPLPSVGRAVVVFEDIEGATLAKQGLDRLVLPFEDSEVQGVERAVDADDGTMLRAIFGPRTDPTTEPETLAVPTTDKNFLISPPGSPPVGWEPIREDPPNRDTLAEDLMKALADLRDTGSHIESHQPQVWGEAGSGTQSAGRGSGGLGTPEVILAPSTAPAMRSFQPAWLRGAGENTQAAEDEEVDVPGVTVQSFDADDGQADAGGASKLYNGFSISSVKATVDSLRGPVQLGSSGGLGGELGGDSGGARRITPTGRPPLNTTDYPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ33</accession>
    <name>W3VQ33_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ33"/>
    <dbReference type="HOGENOM" id="CLU_1732259_0_0_1"/>
    <dbReference type="OrthoDB" id="2554683at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16107" checksum="BF01EE131DE8E96C" modified="2014-03-19" version="1">MPTATHSIYRSLDHANNDPLDNTAANLHWVTPSFNTLNMRRTAPSSGFFGFAKSGQRFKVVVAGVPNGTYNNAETATLIYNIITRLKYGSQLDKTPHLLNQVGVGADSLADTLLRVYEDSLLAPSPRVAAPVLPAAVLPPAAPSPSSLEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ96</accession>
    <name>W3VQ96_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ96"/>
    <dbReference type="HOGENOM" id="CLU_371794_0_0_1"/>
    <dbReference type="OrthoDB" id="2552174at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="649" mass="70223" checksum="0123ECBC1B20C34B" modified="2014-03-19" version="1">MSRRDVDLEFEQAYQRLFSTSSSSVAEQQGPSTSSVKRDARPRSSQKPHRSHLTKEVGEAARPSGHARQHVLALASQRKASAAKTHPSVKDQAQARSHAANREHVASSASRSEQAPQRYASAAAKGKGRARPYTTEKHRHADPHVPTSIPTTASTSYGAYVPPASMAYYPYTQSHAPFQVSAPVVAPGMTALPNPTVAWTQPMMSTGPVPAIAYPSFSASVTFSQPQFFASQPHPIPAGMMPPPSESWSSADATGSTQPPRASGSKTAGPVAAQDHGTSALHSKHKYPKRHRASVPAELQPPLLESRASEQLTSILRLPAKIAAVKKETLKPELDDSKTPIPKRRGRPPGRTKATLQSGTVFAPAEPKSRSHSPAPPKATVVPAKFDGCLPLREHAGVPQNRETHTLFIHASRRLVWLAQLAVAHSAGDSKPSATLDTRAWARWSNSIAARLHTLGGEPGEPGGPGVAADADDALSCASQSQADPAGLFPRHRRREYVALRKQSHAATRTAVLRICIRRLRRYLAQTADKARTAPQAHRTTYLNRKLRAAKLGRHLHRALRPAALDARRLWSNWARTRSIAGSSTARVKLEHDDAPEVAVGVKMEPSDGVATLPLDEGRDATVRTHAPLFLRRNFKLYRLLGIRALPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQK3</accession>
    <name>W3VQK3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQK3"/>
    <dbReference type="HOGENOM" id="CLU_013513_4_0_1"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="7">
        <location>
            <begin position="50"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="728"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="762" mass="84948" checksum="A83F929DC3F2236A" modified="2014-03-19" version="1">MAPGLMSADAKGVFNAQAVEAKSAAKDDGGANEGLGGGKTFEGQSKLPHLPIPKLEDTCQRYLSSLLPLQSPEQHAATQRIVEDFLQNQGPTLQKQLQEYASTRASYIEEFWDESYLQASDSVVLNLNPFFILEDDPTPTRGNQLMRTANLILASLAFIHDLRTGVLEPDNVRGTPLDMYQYTRLFATSRIPTANGCRMEVEPESRHIVVMRRGQIYWFEALDEEHRPLLTERAMLGNLQAIVRDADKIQIDDVAKGSVGILTTEKRPIWSMYREHLREDSHNRKCLEVVDTALFVVCMDDSEPADAAELSNNMLCGTYKLQRGIQTGTCTNRWYDKLQIIVCANGAAGINFEHTGVDGHTVLRYAADVYTELIMRFAKSINSATKSLFKAKTSPYAKGAGKKANGSFSEADAQKAQDVNQATAPKKLEWNLTKKLTDGIRYGETRLSDLICQNECQVLEFDRYGKNFITRHRFSPDAYVQMAFQAAYYTLYGRCETTYEPAMTKAFLHGRTEAIRTVQPHSAKFVETYMSDAKTDAKLDALKKACEGHAKLSKACATGQGHDRHLYALHNLWKKLQAERSDDQPAPKIFTDAGYAKLNHTVVSTSNCGNPALRMFGFGPVVPDGFGIGYIIKDDGITVCASSKHLQTKRFLDTLEAYLLDTQRMIIETYKAANVRSQSTYIDHAGVECDVRTGLPIGSKSNGYSLDYDQVPAQHFGQSGYSFFGDEKAAAKKDEQHKEDSGQSRRRSRLASVGKTILYDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR28</accession>
    <name>W3VR28_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR28"/>
    <dbReference type="HOGENOM" id="CLU_486722_0_0_1"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="560" mass="61166" checksum="9F0DD74312E64EA4" modified="2014-03-19" version="1">MSRAHNTRAAAEGVDCLRTAGSGAGGRGDLQGNGGRSMPCKFDGSGCRAKHHRSTHSRRAEDSSCVEASRAVPAAALVETLRDPRNYRSIVGVTHAYGACWTRSSPGVRDDGLNPTDGVHPQSCAKVGVLARIDAPQPAGVLFVGVSMQPSPRTRVKADPRVRRRTSPAKPTLVVARAGNMLRRALRKAAKLREAARPSSITKVQDQRRVKAVYATGPKAQHRVCAYRGAEAHAPLNAAMSIILQATTPPSQSNVTPEKDGNRRRNRSQSDSSGDFITDLSMSPASSGVGNSKALNFPPLGWDFFLPCSELRQGPRKARRSSTPSSVAPISDTITGNIPFNTSRWISERSIKKKSGPTHPYSRRATQLARVAHRKDKLNTAKAIRGRSSNAKVDRLSTLILMLPDELDALPDLAAVHAFVADTFLTRHEDELQELKAERRPGRPPHKRELEIKELMAKENQEYLEGFELPDLTSATNVKLLRDWQGDPQALPLFRMVRISARYPEQSKLMHPGNHKLLQLELKQQQDATSADAAADMDTTTSDSQDTSSFQRVGEFAQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR49</accession>
    <name>W3VR49_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR49"/>
    <dbReference type="HOGENOM" id="CLU_659217_0_0_1"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46933" checksum="09A2F7C2EC93FB06" modified="2014-03-19" version="1">MAEPDAQCTSQAGDDILRPYLSLDAPRLVLDLRPDAAFHREHLVQSYHIAPVSELKSRYSYLPPRNVPFLVLADALQRDDVIEAFATISSARIVLLGDERVHDQGAAPPGGVRLCSSTAFFDSARQLGLVRSSTDHQQRIAADDKQDVPTLLFRPSNAVRRTVLQLEAKPQVDLSPRRVLDLGCGAARDLAWILHGSRTRSAAASSRVAWTGVAIDNWKAALRRAEQLMDDLHLDPSASQPQPSTQSSPACEKLLWAKCTDTGELEPLVGTGKGRSIRSAAEDADLWNEYVQVGLEPLLPSVKALDKDSPHAQFDLILCVRFHPRALLPRLDRLVRPGGVVLLSHFVTLSDAERDAAAQAHPHATLDYDSPPHEGRIQPGEAEALVDAWNRSPDSLHTWRVADSVLEPIEDGRIIKSVALCKTRRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRB9</accession>
    <name>W3VRB9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRB9"/>
    <dbReference type="HOGENOM" id="CLU_765427_0_0_1"/>
    <dbReference type="OrthoDB" id="3362926at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="378" mass="39962" checksum="39825ACE3EC5CF07" modified="2014-03-19" version="1">MTGPMDFLRSWTDSGPLETAKKVLESALFRSPEPQPVSAWRMLIDPPMPYWVTIFSQACRLISLLILLPIILIGVIDFAGYAVFRTLGLHRRRVRIQRQSKAGVAVPVGRSSSRRKPRVYQNDRHRPTDRSNIPSIVKAPLLSPGTYDAETLLRQRARSLSIASAEEEAAWVASGGQQARLSTLSKDQEPSLASPTSPDSEGGSLGDDEPRDYFGRAPRVGVDGALGLADTDVESGTESGSNSPVQRFSHLKGSGGNSRRRGLSGGLNFTPVSNRTGSSTKSGVLGEDADDSVTAMQHTDSNSASVVSLGSSDSPDSSSNGDRVRARKGDDAGSANLSSSWIGVDPHDAAVPPPVDAATAAAAAGLEAPSNVWSTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRT3</accession>
    <name>W3VRT3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRT3"/>
    <dbReference type="HOGENOM" id="CLU_006504_5_3_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834534" description="Laccase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="102"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="245"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="542"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="817" mass="88746" checksum="65AA13FF83640E44" modified="2014-03-19" version="1">MRLLQRFFARTSLIFSLFLIIALGHVAVAIPVSAPGHRGAVAGATFDSPHADAEVNHRHVLIKRHKQISSASVPAGFVYPTHHYRRDGDALPAPDKSLNMTVTQGTISPDGFERLGFLMNGKYPADPFIWDENDDIEITVNNEGPVPFAIHWHGLHQIGTPEMDGVPGLSQWNIYPGQSFTYRFKLTNQHGGYWYHSHERGYYADGLRGTFYVRPKAGRSKPWSLISTNADDIDQMEAAEQDFQIMSLSDHWHINHTDMLLVVHESGVPPACFDSLHINGRGRQYCVGNWTTVMSPVELSLLQNFSSINPTGPTSKGCISLVPAKDGYTVKDTLDTMYGGACQNTTAPLTVFSAAKAIKAGRRWLNLQVIDQATNWLYGISIDSHRMWIVAVDGHYIEPMQVDWAQVTIGSRLSVMVELDANLTGSIFPIRLTGARALQPIEGHAFLSYEDDAGDTWNPGLEEDFQYAMRELSTAHVPMSGFVSDASVVKWQPNSSFPFDPLSTVPRTANMTLHAVASQNSLNVWQVASTPLDTVHLADERPMLFNATDGNVTSNQMNPYATIPFGTVVDIIIENNIYSIVGGPNSPHPFHMHSRRFWVIGAGAGPFPNNTVAEAQAAGVIFNLDNPPLRDGFDMDANAWVAIRYIADHAAANILHCHIDDHVIQGMAAVLLEGLETIPAGGNFSEAVVQRPTAWEETQNDTLGQVLEAAWSTGAAATKWIEPAETETAMPWGDPRSLANSIQLLASSNSVQRSITSSLQSQMSQVQATATGTITAITATVSGHLTTFTGVPSSSSSPSSAASVSLTANAASATAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRT9</accession>
    <name>W3VRT9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRT9"/>
    <dbReference type="HOGENOM" id="CLU_005652_1_0_1"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="510"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="632"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="845"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="910"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="776"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1243" mass="133235" checksum="28B862691BC0DD9B" modified="2014-03-19" version="1">MSRRALQLQADEPWNSQPPYRIASIANDADPIVEPANPARSNRGRARAGTLPSSWGDAVPPPHPHQPPFSNPVFQPPHPPSSNPAVVDQPTLAHIDATRFDSALPTLAAANDALPAASTRLAPPQTSQRLRSGSLTLPTPNLANAFGPSFFSSQWQPTRSGLSHMTSATTDEEPYSPFHPSQDNTPQLSFDHADMLDYLGLDGRAPPSHTGPLDSDSFDHRTDHLSTDLGRHLADQDAFFSSAQLRNRSSTLGVHQLRPSLNQGQAGRARSSSYLPSFAFSAATNTADTNPQPAQIHTQGLTRATTLSGSQTPYAQQPPHSSLLNTALHNRLHQYSAAASSAAPLSGRAPINASRPRATSMGVLDQPQSRPPPHASYRPTPSAAAAAPGASLLTPPGSAGSSGLGVPSAAIGAYSDELSGLLANGRNRAGTIAAFSGPGGRARAEQELLRMTQLQYEAALTREFQAQTRPSSSGMLDSMPTLDMYASARSPQPKSAQRSGSNSPFLQPTRSLWIGHLRPTVTSQELVQAFSPYGAIETFRLVPEKGCAFVNYVDLADAVRAREDVVARLGGRLGLGTLGPEAQVRVGFGKPEAVPQPGLGGFTPMLDSYASSLDAAAAELGGVEAASHEPSRALWIGSIPPTTSSDVLVSVFAPFGSIESVRVLSSKSCAFINFERTEDAMTARKLLNGRDVLGPEVGAVKIGFAKVPSKPSEGYFAALDPGSAEFQAAMEMLASMSATGPPPPQDAQMAMGQADYRANASYDPAARQHLQPVMAGSHGLSRNQSTESSRGGAAGTPGRVAGFPTHSSSNSIVPSSDKGGVPLPAEMKPRDTINDLQQMMRQLDAADPNVESDVARVARPRSAVTYYTRIPPVQELPLGKRFDNNRLKEVRKRLETPHCQPGDADAIARDYLSCVVDLASDFIGNTLVQKLFERCSEPMKKAMLELIAPHLATIGVHKNGTWAAQKIIDCTHADDQRAMIAHHIRPYVPPLLLDQFGNYVVQRLIPFGTPHSDFIFEAMVDRCWEVAQGRFGSRSMRACLESPHVPRYHMKHVALAIVLNSVPLATSQNGALLVTWLLDSTLPGRFSLLAPRFGPHLVNLCTHKLASQTVLRLLSQKEDIEAGRQVLYRLFDSNRLEEILVDQVHGSQFVTKLVTEILDAGEKQRCAEEVKALLVRHGLVGLPPYRPLSIELGLVQAVPVERQLAAMSIGAGMEAFDPWAGEEATPAHKAVEQGFYGSNAPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRU9</accession>
    <name>W3VRU9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRU9"/>
    <dbReference type="HOGENOM" id="CLU_515024_0_0_1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048420">
        <property type="entry name" value="Zap1-like_Znf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21816">
        <property type="entry name" value="Zap1_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="486" mass="52130" checksum="B2C433F5A3C2C236" modified="2014-03-19" version="1">MPRRKLPAAGAASTSSSTPAAATPSRRMEAGPERSPSPSSSLGIGRASNPPSSPHKPPRSKPAMPARAPSPTLSEISTSASEGEDGVTSSAPRAARSASPEGDELMDESMRDSSAPNDAEVTCQWNDCGETFNSLQPFIDHLHHEHIGIHKSKYMCEWTGCIRKGKPQTSRFALLSHLRSHTGEKPFTCPRPECDKSFTRSDALSKHMRVQHNIITAGSRRAAASNAADEAEDASMVVEGAEATPAKPAGGATDSLGDELLELAGGEADLLAASASGEANLYTMSAEELGISERLGADSDAEEAKRNEAVLGRALRVWAKDVRERERNRKPRDPASRTRASASGEPEETNGKRDYESDSGDSLDVSVRRTRRNTRTRRSSRFAEDGSMEAAKTAIASARTRYVVEKAKLRYVRAENARLWRQLHQLEAQQHAVARQCTQALEHALVEELGQDVDAIFTPPASPKSAAAAAVAGDNEALVDDHRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRV6</accession>
    <name>W3VRV6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRV6"/>
    <dbReference type="HOGENOM" id="CLU_003701_0_0_1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000534">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="259"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="261"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="884" mass="94721" checksum="AA341FD15AACB0AF" modified="2014-03-19" version="1">MDVSARARARADAMPASSALLLQHDSRLDSRLDLEERSQRHRGSSASDGRDAREARDGAVESLSQQLQSRSSPTAASVESFSSYINKDAPLFQQRSSSPRAEDQLRDHSDPASHTGSPRLHPRHLVSTPVVSRDAFRHRHWADSDPSHPSAGVMSIEHLHNTSQTPHHLSQHAHLKPGAQQRIALAISAAHRAADRSALPASPTPAIDVNRLSVSNLAQKNQEDDERDPTYRDPRMRAPASLIDDSFESTASVVGEDAKNEIRRRRRTRPDEANLLAQVYATNAFPDHETRLFLANRVGMSVRAVSVWFQNRRQAEKKRSGRYGGSGIAPNAGAAPSTGQSTPAVESTPAKPSATVLAQRKPLGNASENAAAAPKRSEPVEMSDMSSDNKENIPPWLVARATTSRHPPLEPLKCQTPAKPCKDTLDESAPASTLRDLRRAVGPRGMGIAHVEVDACTPKTTLSRHRSTPRLSLDDVLSGRSQTLRRAATERAPLAALTADEGLDTILPPPKLLSRASSASSLSLLTTSGGRASIGNIAATPTAASPAASQSESLTSSLPPQLTAVLQRQGIIAGVDPAQGQVERSGLLGMMPSSSVSSSEADAAHDTRDEEDEERTLKLIAQRRAAKGQESRADAREAIANVGGGDAVKKVVGLAPARAVSLDWAAGRDRASTTALPVGTPLSRSVSMRLPTASTPLSTRAPGSAPETAAGDKRKRPSARSLSATDLTRRLQDAKRKTDRPATRKKPARVDENIAPTAQLETAKRRRVEELPPFGGIGMVSPMLSRSFAYPSRPVGLTATPQYVRAVSTPFARRWDLHTPSRVLGDRTNFTPAPTAQAFSHDDSGFFDCDSPQKRDDPNDHQAAELLLGLGKSAVDSRDSSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRX9</accession>
    <name>W3VRX9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRX9"/>
    <dbReference type="HOGENOM" id="CLU_029749_4_0_1"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001940">
        <property type="entry name" value="Pre-rRNA-processing protein IPI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="582" mass="61000" checksum="1730FE6CC515C3A9" modified="2014-03-19" version="1">MASSSSASSLFATECLLYSTASSSSLVGSMGLTTVTAPSSTSALFTFKGVSDLASHSVTVIPTSPNPAVSGVGGLVLQLENNKATLNVFSWQRDHPLQRIILPQKLACIAASPNGELVAGGSFDGRIFLWQIATGDLLASFDAHYRSVTVLKWTQDGAALVTGSEDSRILVWSLAGLLAPHDQTSSAITSSEHNPTPYCTLADHNLAITDLHIASGRFPNHTTILSSSADSTVKMWDLRTRALLSTFIFEQPIHRVVLDCTERFFFAATSPGSGENAVYRIDLFRKRDASSRMVESKIATNGSAFDFVTDELRGATAVEAYGFGSAAGPTTERIASANDAAGRAAANGSSIIAMREPISSMCLSSNSTSLLVGSAAGNLFVVDVSNSQILRTVSMLGNAKASAVTGKNAVTNLVVLPKPRDLLGHWETAGQSGAGSAIAGAGGAGANAAGSIPVRPIANFSRHVLASEEERLTTPYLTRIADTANTPLAHDGVDSFIDPQWDSQLVSDDLLGAFSSPMGTVNAPAGVASVKANGHNAEQTDKLSQENQLLRSQLQQAKAINDEMWSRLVRDRLTSQAAAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSB1</accession>
    <name>W3VSB1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01243</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003488_0_0_1"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="10">
        <location>
            <begin position="185"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="889"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="11">
        <location>
            <begin position="1136"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1098"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1386" mass="151423" checksum="7473B57861BFDF4B" modified="2014-03-19" version="1">MHQQATPLFRHPALSLDTIRLGHSHSFLHHAFSSPYARHPLAQLESQSRLSTASSCLRPDAAIHAIQEVSVACASATTHIMFDDFVQSSAAPRTPPMHKASNQYADSPATNGHHANGHGARRGFAMNDGFDANEFEPRGGRSSNELSDGAGGGFDTATSALLDPIAALETGFISSDAGPSSHSDPIFQLGRVQYAFSAPLALMTVSSNILTMCLYTYPSPSQAASPFPVAPPKLVRINLDDPEHTQEADVPIPPAPRSARNAPPSDPSTIGPHKMFADPSGLHLVLAMRNGDNYYWASGWRKARLLPKLKGHIIESVAWNKDSTSSASDSSSSASRRRAAGGASSLSSTREILIGTRSGDIYEALITAPLGTDPDDGDFFDKIARRTAGNGAERGDVDRVVRHMIALPERQPVTGLHAESFPRSAGTTNANAPAASTSSELRRAVVIATTSTRIYEFVGVLSKSRSDESEAHSLYDKLFLPYRGDASPNLKSELPGDLPYSELHTWTSASSRHASALAWLTGPGVYHGLLSYPSDATAGDSVVESANLLPYPAVAIEDDLGGSPNKRRSRLSTASAADTSAFGQAAAPITEIPLSIALTEFHFILLYHDRVMAISSLDDQVIFEEALPLKSNERVIGTAIDVAKRTYWIYTDASIFELVMRDEARHVWRVYLDRGSFDAALKYAKPGIQRGTVLSFQGDRYFAEAKYIQAAQCYAQTFMRAFEEIVLRFTDADQRDALRYYLVMRLERLDKTHDVAQRVMLATWLVETYLSKINQLEDVAAAEAASQDVDNYRLEISMITEELYQFLTTYRSLLDASTTFDLIKKHGRSDVYLQFASVIGDHERIVRHHVQERQWTKAIDAINRQDSLELYYRFASVLMQNAPAQTVDCWSRQARLDARKLIPALLQHKPDLELGETDQAVKYLSGLIAGKNGSKDTAIHNLLLTLLARRASRYSSRQDTKQELLRFIDEARANPLTGHPYFDLDYALRTCLSQGQMEACVRIYAKMGLFESAVELAIRQGEIELACSCADMAESMERELRKKLWLKVAKEVVRKESDIKSAMAFLRRTDLIAIEDVLPFFPDFAVIDDCKDDICEALEGYAAHIEELKDEMDEASRSAAAIQQDIAKLSERFVTIEPDHKCDHCTQTLVQRQFYIFPCRHGFHADCLIGQVTKTMSTRSLRKLLELQQQISALTSGLVPALPSSALANMGFLKDPSKAVVSAAQGASKAGLSGLQAGARGLGNVTAAVGLDKLRELVVPDAVISAISAGVSVSVAGGRRVLAPLDPFSNPTTDWVAGSRTAAQRRAAALIASNDSSEANGSIADGNAAKTAMGTYRSVEDQERIQQLRDQLDALIAGSCPMCDGTANAIGRQFVSDKEAAEEWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSL9</accession>
    <name>W3VSL9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSL9"/>
    <dbReference type="HOGENOM" id="CLU_451365_0_0_1"/>
    <dbReference type="OrthoDB" id="2553048at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="595" mass="63565" checksum="3ACAA27A20B8CD6B" modified="2014-03-19" version="1">MHSFGSSVLSLPSAAASARAEKKSKRNVLRRLSLGKPRFSSDVPSSSTASLASRSTVTLAVNPSEEGSSRRAFDLFSTPLPREERDTRSAPSTPRTSKAPAFALPGLSSKVSFDEKSIPSYPRSRQSLARNSTNSRFGGSSVPPVPELPKLVVVSNEVFVIAALPRSKNLPELPTSPLLLSSSPGSSRSSASWLDNLPTPSISEEAPALPERLESPPAPDTLAATKRSSLDEIDAQMITNLCEMPAPQLEAVSMARCKSSQGSYCPPKMHARSASQRTAPQASVETHQRARSHSRSGSAPQSLGPLPPRPAQPPTEAVLRKTDQVKKRYSRQGTVSPMPSPVLSDSAFSSPRSAPATPKLDTVAALKSLEAGLSLDSKLARRNHKRSSSRTGGATWDAAFKSSTAVKLTAGHSAARDEATTELVSRFSEDSDSGESSRLRALLSPVLDSVAKMPPLFGISTPSVDTHSSFGTRTNVVLGNKSPELPSLCISSSSSSSGSDHDHADLTPVVSIEEDDTIFDLSRPSMDYNAVYALAQQYAKASAPQPVQLHDMARSNSGRVQAQTKQARPIYLNTLWSKASRNLQDPVDRSYHLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSR5</accession>
    <name>W3VSR5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSR5"/>
    <dbReference type="HOGENOM" id="CLU_112099_0_0_1"/>
    <dbReference type="OrthoDB" id="10250777at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833573" evidence="1">
        <location>
            <begin position="25"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="210" mass="23220" checksum="F2DFB821BF753E40" modified="2014-03-19" version="1">MISMSKLTAVLFALLFVQATFVASAPLDGAGANEARFALASRASDDTVWVSMLDSSATSRPNRALYPGTEVPSDVMTHLMSERHGVENHVPMGVLQNHWNNVIGKFHEMILDPNTPVSSMKHDGETYFLTRFRPMRGSPYPEWSQMVVPTAYVEREALYPIFIGKIGSRTAHGQNIQLLAIRSPATVAERASFVISLKSSRNLVHLTHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSX9</accession>
    <name>W3VSX9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSX9"/>
    <dbReference type="HOGENOM" id="CLU_858217_0_0_1"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="10">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="324" mass="35014" checksum="FA30F3A5AEE31D9B" modified="2014-03-19" version="1">MSFTVAQRQRAVGLYKRLLRTSRKTFDGDAVAIAAARDETRRRFKEAAKETDATKIDDGLKMGDEIVSVLRQNVVQGKWRQEKEAYELRMTKDTELGNNDSIKEARAKQIADLKAGKKPERKSCREMAAQYQAASASTSSLGASSSSSAPRQMRAYSSMSARPASTILAQAISFQSQRSGFASSATASIRDPSAASQAPLPRPVPKFSSTTILADGSSIQLATTSPRRLTRLTRDPTNHPLWNPGQERKVGGDADDDSGRLGRFRRRFQEAEAAGAADGKAKSQSGGDVKFGQEDLDWMSVGGREARAGSPIAAKKAAKGKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSZ1</accession>
    <name>W3VSZ1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSZ1"/>
    <dbReference type="HOGENOM" id="CLU_984102_0_0_1"/>
    <dbReference type="OrthoDB" id="10258821at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833582" evidence="1">
        <location>
            <begin position="20"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="262" mass="27514" checksum="6D505EEFCDC51EF8" modified="2014-03-19" version="1">MRVLPAFGGLLVALQLVAAVHLDQLDSVRFAKVRRTVSGPSKGDLKRRAIEQIVPGVRELVEKFEGQTGAKSQAEFVAQLKQLVQGSDQAASPKGKEVMNHYQTGSSSAPSLTFTHPAEGEALVNPRFAEHDNLLNKHVKALDDQAHTLNVHEQVLLKSMEGLDTLNGRLSAVEASKEKLLEAQKKSNRGLKWGVGTALGTATLAGGASALYAQGSKDHINALSDTVAQQQAEIEKLKAASAGRASTGAGIQAGASTSGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT15</accession>
    <name>W3VT15_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_00644</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT15"/>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834555" description="Mannosyl-oligosaccharide glucosidase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="16">
        <location>
            <begin position="72"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="15">
        <location>
            <begin position="358"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS64694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="868" mass="97272" checksum="52F954C85EE7A680" modified="2014-03-19" version="1">MVTYRASRSTWPIRTLAVLLVASLALLLVLGTDSARAYDQDDFDDDLDGDDSVPSFVKSPEAVQAQADADASLLWGTYRPQIYFGLRPRLPDSLLTGLAWFGLQDYSGFQKMRHQCSDQDGMKGFTWKYHDGREFGIQEINDNVNNYRLETSFLKVDTRNSNGGSWAARVSGTVMDPAKPAALSTFWYTAIESLGSSLGLETEIEPGSGIERQEPVRIAGTVPNLGDFVLRIEEPDAAHGNVNNDGNQFIGRPSANTQAGDFADTAGKTHVFGKRIPTESVWKAKDVILNDLMVNLQQSAETFGHENMPDPAVTLRLSDQVAPGSTLFAVQKSFSGNFTFDVFYDSATTPKGALLSSAGLTQALKAASEAYDRRFESTLRLAPKGYSPQQIEFARDLTSSITGGIGFYHGSAIVDRAFRHEYDAEVGSGVYNPEVHGQADPQPTEPDQLFTATPCRNIFPRGFYWDEGFHLAHIGAWDNDLSLDILRSWIRLIDEDGWVAREQILGDEARSRVPDGFQTQYPQYGNPPTLILAVSAYVDRLVARIEKRGLDAATLSQQQVLADFDALDDAPLSERMLASAALGQTFLHEIYPKLRRHYRWFRRTQRGEIREWDREARSKTEAYRWRGRTKEHVLASGLDDYPRAPVPHTGELHVDLHSWMGSFAETMAKIARVLGRDDDVDEYERHYADIVANLEDLHWSEADQMYCDASVDESDQSYHVCHAGYVSLFPLMLELLPADSPHLGHVLDLLADPEHLWSPFGIRSLSPKDEFFGQGDNYWRGPVWVHMSYLCLRALRNKYATTSGPHQAKAQQIYDTLRQNVVNNTFTQYTQTGYVFEQYNPADGHGQRGYPFTGWSSTVALMMAEIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT35</accession>
    <name>W3VT35_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02289</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_3_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000061">
        <property type="entry name" value="ATP-binding cassette transporter YOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="999"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1034"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1140"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1225"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="263"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="700"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1003"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1320"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="596"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="925"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="929"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="947"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1614" mass="176587" checksum="BAF66BD7112D8BFD" modified="2014-03-19" version="1">MSGTSSSTPPTADPASHATAAVETSTHPAPAPTVVHDTEDESHSESSKSAVASTDQAAQPSIATDEKPGYEYNPGVRSFVGGKHKEKWYQVWRPKNPPLPPPNSLDDARLIPLANASLINRIFFQWMTPIMILGYQRPLEATDLWALSEDLSAKQLGGQLNAHWARRVAEAKAYNEKLVSDEIQPGLKLRASWALASTLNPKGGSRQQREARWRAPPRPAPAAAAAGPPQPGKPKLPKDPSGHKKPSLVWAMHDQLAWKLWSGLVFKIVGDASLITSPLVLKAIIKYAQELYTAHARGVPGPPVGHGVGLSFALFFMQIISSLGTHQFFWRSMSCGVEARAALITAIFDRAMKMNGKARSSGKLINHISTDCSRIDFASAWFTVIFAAPIQMIICVIILLTQLGPSALAGLAIFVIATPIQLQTMKMLFKIRRASMKWTDARAKTIQEVLGGMRIVKSFSHESKFLQRIYDIRKNELNGIRKILIIRSANIALAFSLPILAAVLAFVVYNLTGHDLNPAIVFPALTLFQLLRMPLMFLPLSLSATTDARNAFDRLYTVFTAEQLEDTVEHDEDSKHALIVHDASFRWETVEADEALPSAKKGKDGAAAKKAGSAPKGVESNAGSRKGLFGKAKNFAKKSAAPPAANAPGLPAPVTAKLPDTDNGRRLEQIRAEQSDAAADGDNEAVLDVAKLEPTVGEAQSLEKVEETAQEPFSMSHINVTIPKGELVAIVGPVGSGKSSFLQACIGEMRQTGGSVQWGSERVAYCSQSAWIQNATLRDNILFGQPFDEERYWEAVKVSELEADLAILPAGDLTEIGEKGVNLSGGQKQRVNIARALYYNAEIVCLDDPLSAVDAHVGKALFYNAIMSLRAKGTTVLLVTHALHFLPDVDRIITLEDGHIAEMGTYDQLNTANGPFQRLVLEFGGEKEKDEEEKKEDEAEAIEDSVDDSKKGKKVDRNHLSGGKAGEKAGATMQAEERNTGSVSLQVYLSYFKFGRGAYMVPLCVGSLALMQTTNILNSYWLIWWQKNHFDKSIGFYMGIYAMLGIVVTILTFVMGCAMGFLSYYACKRLHHEAIQRVVYAPMAWLDVTPIGRIMNRFSKDVDVVDNQLADALADAVRMAANTIASVAGAVILITILTHYFVIAVAVVLVFYFFGALFYRSSAREVKRLDAILRSSLYSHFSETLSGLATIRAYRETETFVRENQKRMDIENRAYYLSITNQRWLGVRLDMLGALLVLIVALLTTASSTPITGGNAGIALTYMLTVAQAFSWMTRQIAEVENDSASVERLLYYAEELEQEKAQTRTDNPTRESWPEEGRISFKDIWLSYRPGLPSVLKGISFEVGSGEKVGIVGRTGAGKSSLLTALLRLVELSKGSIEIDGVDVGNIGLEDLRRKLAILPQEPLLFSGTLRSNLDPFGIYDDARLNDALKRAYLIGDDTNTHGAATPIMPVTEPASETASSHDDEKAALAVPGDATPGRNVSRINLDTVIEEEGANLSVGQRSLVSLARALVKNSKIILLDEATASVDLETDAKIQQTIREEFGNRTILCIAHRLRTILSYDRIAVFDKGELAEYASPLELFERDDGIFHSMCVRSNITRDEIVRNAKSSAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTA7</accession>
    <name>W3VTA7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00733</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTA7"/>
    <dbReference type="HOGENOM" id="CLU_024853_3_0_1"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="27"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="78"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="146"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="265" mass="29185" checksum="6290ABB14774EB9D" modified="2014-03-19" version="1">MSTSTNTAAEASSRAPLRLRYIDAATAQQIDEELMSPAGGFSIDQLMELAGLSCAQAVFEVYPPTRYPNVLVACGPGNQGGDGLVAARHLYHFGYEPSVWYPKQGKTELFARLRVQLQNLGVHFVAQDDFQDALEEADVVLDSVFGFSFKGDVREPFKLPLENLKYESRIEFEARKKMPPIVSVDIPSSWDVEKGNVKGAFTPSVLISLTAPKLGALEFQGRHFLGGRFVPEDLEAKFDLQLPDYPGTEQVVEITGARPLESQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTP0</accession>
    <name>W3VTP0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTP0"/>
    <dbReference type="HOGENOM" id="CLU_1134182_0_0_1"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27293" checksum="C7A392218281E8FA" modified="2014-03-19" version="1">MVSSQELESAIRQKVRNVSTLVVSDVSGGCGQAYDVVIVSDAFEGLNTLKRHRMVNELLKDEIAQLHAFSQKTYTAAQYEQMSTSSSTPTPPAAAAKPTSADLQAPAPIITGGSRPSHNRTASGVSIPELTLTTDDDTLSGHRSVGKPLGGATAQGSATQYPGTAVPPPLSPSISRLHENRIRSTEFWTGLRSYLELQFSGPNVEAGAASPGPSGRSPGDAEIERIFEDFFLSQKHHLTASDIARVRDATGMFGMAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTS0</accession>
    <name>W3VTS0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactan -beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTS0"/>
    <dbReference type="HOGENOM" id="CLU_016116_1_1_1"/>
    <dbReference type="OrthoDB" id="9970295at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="405" mass="43970" checksum="7F1E4578B7759308" modified="2014-03-19" version="1">MRGEYKNSGNGFQGFSLYSSSDLVNWDSHGLVVPPSSSLPFQVGERPKLIKNPTTGEYVLWFHADSSNYSLAKVGVCYASSVTGPYTCPQEGVFSPLGMESRDMNVYVDPVNDQGYLLFATNGNADTAVAKMTSDYKNVTTLTQTIHSRLEGFGVFRDDAGLYNMVVSNQSGWQPNANSLYTTSDLGKVNLTYSNYIAPQGVNTYNSQNTFEIQPNDNLDVYLGDRWWVTDLEQSSYVWYPIVSRSLVHLPLWRPDSSAQGYAVPANKTFPLSPSTATKTGSQAAFGDCAACPSGKIATYVGNGNTFTLNDVTTPSGNAGDVWVSVYYSNQNSYPDWRFGSVTVNGKTNNITYPTGGNPANTLQDTPVKLSLQAGNNAVTFGAPANDPTQYAADISHIIVWQSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTW4</accession>
    <name>W3VTW4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Maltose permease mal31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00375</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTW4"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="59"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="545" mass="60761" checksum="22989C6551D4C260" modified="2014-03-19" version="1">MSSLGEKQYGSAEKIDTEAGPTLVMTVTELNEGAKQSAQKEIEASIWQSVKACKTGLFWCFVVSLCVIMEGYDLNLLGNFFAFPRFAQKYGHYVDQESGYQLTPAWQAGLNNGSGVGAFFGTLLNGILVTRFGHRRVLIGSLIALSCFIFITFFAKSVVMLLIGQLLCGLPWGVFATTAPAYASEVLPLNLRVYMTSWTNMCFIIGQLIASGVLAGLVNFDSEWAYRIPFALQWVWPAFLIPLLFFAPESPWHLVRQGRPEEAERSLRRLYSSSVSDHHIKDTLAAITKTDAMEEQMSVGTSYRDCFKGFERRRTEIACVAFAGQVLSGSSFAYNSTYFFQQVGLTADQTYHLNVGGTGMALVGTLCSWFFIMPYVGRRRIYISGMAAMAAVLMIIGILNTRTNNDSVGMAQAVLTLVWTFIFQLSVGQMGWSVPAEVGSTRLRQKTVCLARNAYYIVSVISQVLQPYFMNPTAWNLKGYTGFFWAGTALITLVWAIFRLPETKNRPYEELDLLFAQRVPARKFKTTQVDTTMHKSDNDLPVLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTY1</accession>
    <name>W3VTY1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glyoxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTY1"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="30"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="117"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="37640" checksum="78E8064367C2D3B4" modified="2014-03-19" version="1">MPVPKILVCRTMPTSVLKAAAAAGKVELITRPDDEGEQAPSRDWVLSHLPGVSGAVICLSERVDAEFLDAAGPSLKVISTMSVGYDHIDLALVKSRGIRVGNTPGVLDDAVAELCLLLALMVTRQVPVALRTVQEGRWPSFPWTPTCFMGPSMGAKTIGFLGFGNISQSLANLLVPFKPKRLVYTTSRPRKFDAADGYFGSLVRGGFPVERIAVENVDKMQLAKVADVVFVLVDLNPTTKHIVDKEFLAAMKTSAYVVNASRGGTVDTAALAEALRTNSIAGAGLDVIEGEPDIQASHPLLAPDCRDKVALLPHIGSGTTETRQAMADMTMKNVLGALGLRDGHGKEAVMDAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTY5</accession>
    <name>W3VTY5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Don3 interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTY5"/>
    <dbReference type="HOGENOM" id="CLU_020427_0_0_1"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="82218" checksum="124B365D0738D6CA" modified="2014-03-19" version="1">MSSHGVAHPRSAAGTPTQTRPSFSTARDHFSPGNSRPNAMSRSIDLEATIETWLDALNSPLSTPSERTSTLNDIERLLVNLTDPSSRSSALVGLDHAATFWSLQATAGFSLAEALMALVFRLHLDLQREHELQATHASSSLYAAADAAPPLDGLGIQMSKAHNKQAKMSVWSMSEAQHQRLHATVSEFCIAITILQGLTLCSTSSKRIMRRKSSLELLLQIVLADYCTQLLPPVLMPASQALTPTSPSFSLPPTPSTPASSSSSSPSKSSVTASSSADSVAEAPLSLPSGFALDLLMCVLVDSQEAQDRFAEMGGIHQIVQLSHKCADTVTTPVSTPVTATSPSLRDVAATSAARSGHIVALKQTDLLCLEFRYFWSQLLNSEPARRASLDNVAGTHSAATSFYSVMDPPSTVLVEAETAAEPSTPKASLRKRASRRVLGESETPLVETPKARGRVQAPSSTRATSEEAPSRTLDQQAGEVNASPRRLRHSTSVAELRKKPSVAKSMPPVPPLPILEPTVSIAIKPDAASSERRFASRRPATSGSGSASVRPSASALPGGGQLGERVRRSTVSEASTADGGPDRIKFSPTRPGMSSRERPRIPSPLKPRSAAQQAAELDTQRRADALTNQAIPYRRLRASTASTPFSPTDNVAAAHRDADAENCNPFSTAHTQAKPQQEARTQLRSKRSTHMLRESPQPMADVVAGAGSMRRSDTRVGMVPSESAYSLGVGSGPVKLPPSPAVRRAQLARARSLSPTKLTHLGQRLSVAQPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTZ1</accession>
    <name>W3VTZ1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTZ1"/>
    <dbReference type="HOGENOM" id="CLU_758607_0_0_1"/>
    <dbReference type="OrthoDB" id="2552556at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="365" mass="39930" checksum="63D05E550ACD13F7" modified="2014-03-19" version="1">MSARSESTRSYDADSIFTHDTINTTTDTINTVPSAHPDNLDKHVPAWNHSHMSYHLPAHMQSRAVPRGAAGIERRPLSRFLAPGYPTGASTREQAIYGLHMADGLGTADEIEAAWEDASCIDGSPRLEACKRLSEPPRASQDSFEVEALRRQVEQLTMALQLQSRQRDLERRAPPPTRPLPPWPEHDGRATPSLFSGTTSSSSSRYYRPTPHPAGYYDPSHAMAPRMDHPYGLPSPVSSASRTLSEPADETDLTDLARKVDALHHIVSSLTLAPVASADSAFRYNITPPTSNPAPNDAQTKTTSKLAAALRFKSSSSTPDLPLQDSSNTARVSWSRKRTEKVAQPQTKLKVGPGRGRMIIKDTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU35</accession>
    <name>W3VU35_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU35"/>
    <dbReference type="HOGENOM" id="CLU_007240_0_0_1"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="883"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1101" mass="120830" checksum="F41FA780EFB8E5C7" modified="2014-03-19" version="1">MPAERHTSQHPRHHELGIPPTKHEPELDNGDADTPKKQTARRRAYAKRSCLKCREKKARCELPDHSLTTPSSMTPLSHNMACHRCKVLSLDCVVWDGDRKRRPKVPATASTSTSTSTSASAASATPAPVKSEPSSSRLASSPPRSPGSLEQLAAAAAHLSDRNTAYDDPQDMSPRGPASSNDASSSREAASTLASVQFFNPIAEDAATPSSLASPASLRAPDRSHWSTTNPSTRDPARSPADRKPALPGSAPSPSSTAATSSTPSKVQPPGRTWTSLWRPLSVLIDYAAQQPSFTTYLLCRIDRSLTNIDILDLIPRHTLAHLKPFLKPYILWHPHLPGLDHMYNEHCKRPTVSSALLLSSMCLVACRHAMPLTDPLPVKLSTLIDQLGTQILLSTPRDMYTVQALELLLAHEPSLVGTSVAGSAQAERGNGLLGESLLAAALTIARGLDLDKAIDNLVDLCNRPAPPDDRHGKQRRDLLAKHAAGASIWLSLRIWEGHFSFVNSTVRPIELGDIVDKSDVMVAIDNDGRKIERRERDPFLTTEKRFPGLDEDSILRSAGRTGLVYRLKAMARFQNTIAGMYSILAKGAKQPTPPALIPTTQQTRQELLELLTDSSTQQLIWQSAKHQAFSPFASVRPALLLEDWATMESYSLQELLPCLAICAFMTGELNRGFSANEMIEGLRVDQSFRDQSTCISEKRDVETHLMLSTFHLFDRGLGYSQPDILTHDRARSKMQRGGGLWIEATGAPLLLTTAFATDGCKTFLEKTACSLYGFDHLPVTADMHLVMMVNTRSRLEECDRNEYLPPLRKRSSMPPPSRRLSSLTPDLNDKEEVVQGRSISQIGVIFIDEMAQGMQKWKLGASLHRTVPLHFRHIFGKQRAEAAAQTKDLTSGRPSIDASRRDEASVPRKPDSNMAEGSLSQAQSFSHNFQSSFGAAPQPIATTASSSNGGMFDIPTFDLFGPASTTDWTNHVPWFDPIDTSAPMPGLAPQPAPQWDGVGMGPMQNTWPAPQRQRVDTLPPLQYAGMPPPPPMQPQPSIHAHGYPAHAPNHPAANAAWKDAGQTHTNGHQQHHYNHHRPYYNQTHQAHQAHQPHQPHHGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU76</accession>
    <name>W3VU76_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU76"/>
    <dbReference type="HOGENOM" id="CLU_027444_2_0_1"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="245"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="309"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="499"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS65060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="548" mass="62226" checksum="AB5C49309C3C6E98" modified="2014-03-19" version="1">MEYHPPAAQHMVLCADCGTPITPNNANLCLSCLRNSVDITESVPKQATVNFCRNCERYLNPPNSWVPARLESRELLAICLKKLKGLNKVRLIDAGFIWTEPHSKRLRVKLTVQKEVFTSTILQQIFEVEFVVQYGQCPDCTRLAAKNTWRAMVQVRQKVQHKRTFLYLEQLILKHNAHQNTVSINEKKDGLDFFYTQRSHAIKMVEFLNSVVPIKTTKSEQVISMDVHTSTTNYKFTYSVEIAPVCKDDLVCMPPRMAKQLGNIGQLVLCNKVTNSLRFIDPISLQIAEVPAEKYWRDPLPALATIPEMIEFLVLDIEPTGRYATNSHGVQNRRLEEADAQVSPLNAASFGEADAVYHTRTHLGAILQPGDTVMGYHLRVANFNSAEWDTLPADRLPDVVLVKKSYPERKKRSKNRMWKLKSMAKEAEDPATEGAVGRGAVGRRGGLDSQRVERDYELFLRELEEDDEMRQTVNLYRDTKKEEEKRLRKERAAQIKAEREAALANGGMEEDGDDGMTTDGESEWGDDDAPRVGMDELLDDLEDMAIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUA8</accession>
    <name>W3VUA8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUA8"/>
    <dbReference type="HOGENOM" id="CLU_506347_0_0_1"/>
    <dbReference type="OrthoDB" id="10254444at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000434">
        <property type="entry name" value="Chromosome 19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46066:SF2">
        <property type="entry name" value="CHITINASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46066">
        <property type="entry name" value="CHITINASE DOMAIN-CONTAINING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833299" description="Chitinase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58270" checksum="E5BF3D14D38AA2D7" modified="2014-03-19" version="1">MWKLQLVSTRRSLCSLATLLLVCLLALVGAVAASMQTIDADEYIRLHNAPPTTSKDSSNRTVLAYITPWNSEGAAMVDAHAHKIDLVSPVWYTVLVAPTNSTTPDATYILSGGPPGKTEETWLAERLYQPWPRPRIVPRFYLDGWQQKDYADLLSAPSNWHRLAELIATEVHTRNYGGVVFESAATHLLFEPISTLNSALKREDKSLTVVMQPVRTPYSIGAKVDRMQDSQNRMIVQSIPQLAAVVDFFSIMTYDMSSASGRISSFEGKDFADDSPLRGAKRGSLRQPGPNTSPRWIKQNVDLVLTATRTAFKASLNPKNDDADEEERTEARLKDPSNPFLYSDFAATEELIEDEERDELAAVRGKLLMGMPMYGYRYPLFWIDSTGQGVPVPPPSTPREAEHLHERSAPSASNRVVPFLRGPGEAVTMQGIIDTISDHTGVIVNPDQTHAEGWFDYTQIITKHDAIPGAKEGDHLYWRLYLPLPHSTRARTNALKELEDANPGLSLGVSLWELGQASPLLLNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUC0</accession>
    <name>W3VUC0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUC0"/>
    <dbReference type="HOGENOM" id="CLU_020336_7_0_1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="147"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="495" mass="55468" checksum="44AC4132FFC7F753" modified="2014-03-19" version="1">MLRASRRNADRDQLPICHSATNRPDDKVEFKARCDSLWQSRGTMQSCIQHCSPAKRVPAKTKPSRNAVSALRRAKTSSTGTSVHSSITTVLLLASIISPTMLDATASRFYTTPMTTPPSRPDATPTQRRYHYLDHRPPTGVPERATLLLLHGFPDFSYGWRNVVAPLKLAGFRLIIPDLLGYGLSSSPPTSAASTAPGTESRLAEYGGRAISIDLNGLLDHARAAQGSEYGAESLTSDGRNGRVIVLCHDWGSWLGWRFAQWYPERVMGVCGLCVPFQAPTSKYLSIDMVVKNVPNFGYQKFFSEERSTKIIEQHLERFLAIIYMIPGLFSADSENDEEIRDWHLLGKLEKLITMPEFSDIPLKYLGRMILDGEQLAHYERIFRSRGMEGPLSWYRTREVNWQEDRALTSKTLPESLPALLISPKDDVAVPPAMGRTMLKHVPQTEIIEVAGSGHWVQNELPGVVVQHFKEWVERSVLPNEKKGSGMLGWLRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUF9</accession>
    <name>W3VUF9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUF9"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_0_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="257" mass="28365" checksum="E3744D9E1A4081CC" modified="2014-03-19" version="1">MSYDRALTVFSPDGHLFQVEYALEAVRKGTCAVGVRGKDVVVLGVEKKSVLQLQDARTIRKTAMLDDHVCLAFAGLTADARILIDKARIECQSHRLTVEDPVTVDYITRHIAGIQQRYTQSGGVRPFGISTLIIGFDANESKPRLYQTEPSGMYSAWKACAIGRSAKTVREFLEKNHTDELDKEATIKLAIKSLLEVVQTGAKNIEIAVMDAHAKVRNLELSEIETFVDQINAEKDAEAERRRTRMAATAGAQASMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUH5</accession>
    <name>W3VUH5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00321</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUH5"/>
    <dbReference type="HOGENOM" id="CLU_337417_0_0_1"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="673"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="844" mass="91391" checksum="BF42140ABEE290C1" modified="2014-03-19" version="1">MTDPLDLSLDLLRRLPPSKVEANLESIVKLIPSYADDLYSSVDQPLRVKIDDSKQGAGREFLCCDYNKDGDSWRSWISDTCHPPISADADESVDGEPGTRPSASLRSLELKFNDAFETYAKLYYENALSSVYLWDLESEPSSLASAAVGGTQAPSTFAGVVLLKKTIGQDGGNGVAGAWDSIHVFEATERASGSSRSPSAATGASASYKLTSTVMLSLVRRDEGGDAADAKATSTRVGTVEIAGSLTRQSEADYALPDFVSHVANVGRMIEDMEAKMRNQLQEVYFGKTRDVVGQLRSTQSLEKERRARDLQKELMGLWKNSHVSLRAVSRLPSPEYHPAEDQLSQRKKESAALAQTSSAQLMQGSALRAEKRGSPTRRPCTALAQPAARPAPAQLRSDAATPHAGVGAVVAFELAVFRPWRNENWPHGFAHGVRNEFFKLRQEVEQAVNEIQRDFRTRRDERRRGDDGHTRLNDDELDDFRRGVGEEASSERSQHEFEMHEREASAYRDQLRASMMQASGSNPHHSSDGLRRRRRSTADGASGVAQDENATTTAVDEVRITASPELPHHKLGNASPSIGDTASLADAGDSRFNSVRGRAIKTEPREALAEDAAENDAAKNGLLGLDFSRPDTPPSLDPAPSEPHQDSAPSQRDPFADIVDDTASSWHAVFDNRSAALSRRNTDDEVSVIEYPSVRGHSSEEGHVELDTNGLSQTLSEQHLGAPRHDGMSSVGSSPYRSNRALAEPSEGSGAGSRSDRSEPDFEVISDTAESEARWSHLDAPPSPTISSASEALNVTVRREAALSPAHSDAGDSDSWAGLSEPGSDTEAPVGARMQSGSLTRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUQ6</accession>
    <name>W3VUQ6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUQ6"/>
    <dbReference type="HOGENOM" id="CLU_085773_0_0_1"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257:SF1">
        <property type="entry name" value="DUF1330 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS65259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="294" mass="32481" checksum="70D603F4DCFC5121" modified="2014-03-19" version="1">MPVCALHLVRLNDASSSGIDSFLYRLFGGEPDDVNFGIVTVSRVQSPIIRPTRIDTTLLNATPWTLLLVASGSSAHVLPTHLEHDVRAHYSVVAGIPSKIVTNYHTISAKLRDVQPPPPLLEVKLDHNNDVIPPPSFSRDTRSDGQDLSLSPALLDLARHLNHNVKHHGAVSMLNLLHFHTAPGAVESYHEYGRRFATVAGKRGGNAKLVGVVISPLSQGLADSRGQPQRSKDDWWNECTLVHYPSINHFIDMSIDPEYQHINQHYRLSAIKDTALICTTEIDLAPFRSPGYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV22</accession>
    <name>W3VV22_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV22"/>
    <dbReference type="HOGENOM" id="CLU_010539_1_0_1"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="80750" checksum="5516458B90DA2DED" modified="2014-03-19" version="1">MAAPTPTWGQMHNETNEISETHLPNYQQQHGLNTYSPDDDEKKSPVSSQEGLDSQLPVTGYYDAEKKAVAGDEDYVPEDPSAGLQFDLKYFPEETTQLTVRALVVGTVLGCVIAASNVYLGLKTGFTFGASLFGAILGYSIIKIMQKALPEKLGGGFFGPKENCTVQTSATAAGSLTGMFVAAVPAMYQLDLLHDPLKDFARLITFSAVSAYYGVFFAIPLRKFYILKQKLIFPSPTATAYTVRSLHAPGGEVSAKKQSRALLYSFLGAFVFVVVNQYAPGILMDWHIFFWLYKWGWKKAIVVDNWGWWIEWTPAFLGAGMLSGMNASYSFLGGSFLMWAMIGPAIIATGQATGRHSGLAADPPEPLRWGYTSMSFNPNKSPLHAASPRYWGLWPGVLMMFAYSFAELAMNGPTLYRGMRAGAMELYCKVTKKDIPIYEDAIPDPVEKQDQVPVWAWTGGLALSVVFTCLVCTLQFHMNLGNVILAIILAFIFSFVGVQASGATDTNPVGTIAKASQLVVGGALRGQGKTGPPGLLENLIAGSIASSAASHSVDMVGDLKTGHLLRAKPRNQFWAQIVGSFFSIFVSTGLFVLFTKAYPCIIDAAAEECPFAAPSVAAWKAVAVAVISPKLPVSLSSGMTAIGFSIVAVATVVAKYTIIPQKYHVYVPNWNAVGLGFVVPQTYYPIAMCMGATSALFWKAKRPQSFDLLAFAIAAGLIAGEGMAGVFNAILTIVNVDGSVYGTTVAIPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV92</accession>
    <name>W3VV92_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV92"/>
    <dbReference type="HOGENOM" id="CLU_058475_1_0_1"/>
    <dbReference type="OrthoDB" id="408973at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265">
        <property type="entry name" value="BLL2707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265:SF1">
        <property type="entry name" value="GLYOXALASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="360" mass="39584" checksum="37D8560F582AF948" modified="2014-03-19" version="1">MASRSASSGAIPALDHLILLVNDPRTASSQIDSALERAICTFSALGFQVVRGGLHADGITSNALIVFPDGVYIELVQFEAAPGLSSGEKRADFEARRKRHWWYNSRPGWIDWCLQDGISDGMIQSINDNAHRLRQTAHEEEQRESQDGMRIVAPRLRYLPPQEGGRVTMTGEELRWKVSFPAPPEGSVGNPRSAVPFWCADLTARQLRVPLTRSVHENRSPGIAEITLLYARDTVAAYLDVSLALNQPIDAATLPISSELQLVPNQIPHRLLAAPAPAPKPDTTLAKGEGHPHHQAQMPQRFIRVIVKVAEDPQDFAWIERHGEGLYEVAIYVAADKLPATAPPDGIGKFIPNIPYLTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWQ4</accession>
    <name>W3VWQ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006203_0_0_1"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="631"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="696"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="791"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1027"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1311" mass="141510" checksum="2B03CCB5EA7F26A6" modified="2014-03-19" version="1">MNGEHVETAAQQQHQDGAGDAAAAGPSNANQVSTSFFPPPPQIYKKFTKRNLRYLDALNSHKLGEDEPSWDSLTPEERVDRQTRILESAASSSKQSDGEDDVEMAAVDGAAVEASKSSLPDFDLKRTLEPPNIDWIEEDGGYTVFGQLWPIPDVTPTLEQLGIPVLYPLEGTDRKELLLMLLQTLLQTYREITADLLKPAQPYDVWVAAVPDPNLPPEQQQQQLAGNPGFWTQSTEAKDRLKHMQNVVVNMQFLINELRPVQAKETLKLIMQMQLERRKQETQLIREARAAAAPKESVKAGAAGPSQHRLHAKRLQATHHHGSIVTAELLLARQLPRTRLVYTLSCQNLSAVSTYQRAMSRLHPDARSASAVRSFSAGSHASSNSDASYSSNPDAVHTPSTSPALSDRGAFSLDASSWNKLPRAYQPSSPTSAPPTDSKLSPLELLVKRGKQVQQDILEPSTHDASPDPTAHRIYERASALSRRTSVRRPPVQPSPDPDDFDDAQSIRSVNLLSEPGSSFSRNLRMYASTSQNSPPTPSSSGTSFTVQRGYKATYDDQYDSYSPMHASADEQPHSAHLLSNAFRNSVASDISFNSITGASLDTSLSRRASIDTVRSSEFGEDGRWGRAWASRADDEESAYEESVYGDELDDNAGPGSSHLPSRVAAYDIQLDPDQGPFASSGGLSSVAQQWKLNHAARDPSRSAGGTMRGMHASSTPAIREMPSKEKVVSLTRSIPPPRLLDQNQAGHWQQQSDPRHSFVPQIESHNGDAESSHHDAPQHVYDRTPVASADRYLGHRSTSSTATITGNDARESTGSPESARVYVYPPSPSGSEASRASGVHVHSSRDPNHRSQQRFSSMPNPASARIETMSASSSPEYPSQQAGSGEVKRTPLAPSALLSNPRVASAGSLESRRLKPSGHPAGRAPPPPPPAAAWSSPSMGGGTPNGYSDPNQYFQGVDRPIIGRKRAEAIARADGRESMVSDLDVETLRLDGSSRRDSSSTIGSVMTSRMSIGSVAHDPLALQSDNWQERSPVPPQVASPRTPGAPSMQAKASHASFRSLQPAQEAYSPVAGAGGPSRPSMLRNAKSSNALGSVDMQTSVSAPPVGLGVSGVSASQRPRTSPAVDTRTGPSSAEDFLSSGITHHEQGDLARSAFYFERSAKVDGGCVVGMCMFGMALREGWGARKDPAKGFTWIQKAAARAGEMMANTTTPKSDAELRAIKSELKLSVYELGKCFCYGWGVKMDKPMALEYFELAAKLGDADAQAEAGALYAAGKGCKKDLKKAATYYRMAEQGGYDTVGLSWIHKDKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWS6</accession>
    <name>W3VWS6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWS6"/>
    <dbReference type="HOGENOM" id="CLU_1741362_0_0_1"/>
    <dbReference type="OrthoDB" id="2554206at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="150" mass="15947" checksum="5FB25BD0652B5AED" modified="2014-03-19" version="1">MPSSIALSAQLSRRASGDESSSLLPLWIILGVGVALAIGWFALSSCLGDHAREALADRIRGLFSRSRSVGSASFGGGMGASGGSRSAYGRMRDDEAEAFDINAAEHDLYDDLDAPHQPYDHHAAYPPTSSGNLGTSKYNDIEDDGYDRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWY6</accession>
    <name>W3VWY6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWY6"/>
    <dbReference type="HOGENOM" id="CLU_006357_0_0_1"/>
    <dbReference type="OrthoDB" id="2551084at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="761" mass="82652" checksum="AEC164D2BF74DCC4" modified="2014-03-19" version="1">MSKEIMGPLHNATAGEVMELLDALALHIYPRGYWGLTWTTSCLNLVSLMGVVMAMLLYGHRRTPLWFLKLETRTYTVRIHTRTNTSVWHRISTLFHTTPGKQETRVGKFITASCINCHLVFSEVYVLSLFIKTVVSYTSRGAGDAAPVLSPEVWHIIMIAFIFSTAYFSTLGYVAVLAPNTRPVVWNGCVAGVYAGIFVYALACFVGSARSAVQIDALRKAVYDHLCVGAGLRGWKGPGRFDAAARADAESLALVARTYAEAEQRRRWLLQIYSIIAAGGVMLAIVYLVVLAMLTRKIAAELVHIRQTPSAAKTTRHSSMAPVQDVGEAVVISKLLAQPGGLSQLNRARVRTPPPSKPAPNAPLPPTPQPSLRCATPDSTYSLGESAQRHHDSVGSNLAESSPVPLVEKRAQPDTPASPPTCSADGVHDALATDEGYLAVCRFLFSCVIDHVVVALLCLEFGASSTRLCMVFASYPREAHAASIAAAHVDMFGSCWFTLLKTVNSLNLFAPFVLFPASHMKLASILEGAGAHHRRARRSEVRAESQVVETCARASPQPGEAGDVAGYVAMAMRLFRRQARDEPPSTSIATEQSSRSEVDPTPSSAGSRFAAWRGAGLERTDSISVSSHTTMPARRDLVLNALISSRALPIQGFYCHPTPPPYDVHLESNPFQAQCQRSYDSLASCTSPLSPDSSQTLDAVIRTAVPVIIAQPPTPVTAHRPRTTSSVRLKRQWSLPTANDEVEMTTSFDSENFGQCRSNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX41</accession>
    <name>W3VX41_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002960_0_0_1"/>
    <dbReference type="OrthoDB" id="2553267at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050285">
        <property type="entry name" value="STE20_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48015:SF35">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="3">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1651"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1692" mass="180131" checksum="29C29EC060B94A12" modified="2014-03-19" version="1">MLRELSRSRDESTTAASIANRIGRYRRPSNTPASPSSSLQPSPSPRQDYFNAPSPSSSKHTYLSPEERRHAGPAWSDASISPQSSTAVSPAINYDRELPDLPPDALSDIDANQLALRNLQRGQDEVRSRHLSQYESISAFAATIPALNTNPAPATKPDNAKQSAALRFASASTSAAVSAGLGLKKLGKKASAARLRRPNTSQLAQERDASYAALRTPSSNADPQDVAQSPAGSSYASSYASPSPHANSFYDSADPAIGLPYDVSHNVHVDVGPHGYTGLPSSWAQILLSEGMDEHQIRQDPHTAARLVEERTEYLVQQAVQSGADADETRRILSQKLAADHQLSEALAAAASASPLRSRPRRDSVQSSASSSYSSVLEKGWDLGSPPKPQAPQHFSPLPAKSPLLPDFAAEDYDDWATSLLSSIPSGASNDSATARSTAADKASRRRSRSVGELVGRNSLNGLGIGIGIAADATPRRAATRDRDLLNASNATPKASHRLRASVGLDAESNSVNSTSSSRAHQTGTLKHAQSIDEEMQERLRESLDNGDRDPDEDDEEVELVQIAQAAIATKGVLRPVRASQLSARKVSPSSGSLDFNSPHASPNASTTDLHSRPARPPHAAANSVASRPPSSLSDTRMSRSGSTDSYATADSHTALAKYGSLSQAPPRIYTENVSMLADRDLASSPLETSSSGHSSFRIRSPALTVATSSLGHTSPAGTMARGSPSPSLSVRESVSPEVPPKDADWRSRSPALSVSASESGDGAASPAAGSSGYRYGRKGPSSLDSGHVSGHQTQDSWASTAHSITSSEGSHGVTRGLGLRERRHAPPRIYPPSTSTRWAHIAHQDDSSSALSGYAPSRRSQQSPMHAPMQRKTSADALVRADRSPMSDVSQAQQVGQQHHDDRSSIRSARSDGEFAGLDSRDRRQPHYPSSASPTTLDGRPSPSGFFSPKFTQGSLQNGGRGSISSVAPSSRDSMGPPPPPPPKPSVAVRKQPEYILPGADGFYTMPASVGATGRDAGGSDAAMLSAGRLRPPPLSPALSPSSSTEASDYHATIEEWMRDDYSDRSPATTTFSATSPSPSSSSRDSPLPPLPKEEDEETFDSMPQASHFLPSPTVLVSSNEPTHNASQAPARHEKAAMPKTPSGGPPRLELRDSIQDATRLEAYYPPPSPGESIEMLDDAGPGRGSAESGVHKSNAGREAKAESSRERSRDDTRSVISIGPRAHDDARRFPVSMHYASGFDTASMLGDDSEAIRSFRELMLARQSMDLEDMMPLQMGADSSAPPVPSLPSMKELEAKVAAASLSRTGGESGRRSDESGSSSHSSGRATRSSAASPSWSETGAEVVAARLPAKLSHLAVELDLQPLRRGVLCDLEMIGDGESGPVFAANDVVKKRRAAIKMVKFGADADEESSARLKGLVKEVGVWRRCRHVNVLDLYSVVLGSDAIWIVQELAERSLADVIAWKEAGVQLTEARMSRIMLDLVEALQFLHGQRVLHRDVRSDNVMVSSTGVCKLSDFTHAGELGAGASWRQSVIGTPYWMAPEVIKADRYDTRCDVWSVGVVLWEMVEGEPPRVEFPPLRAITLTATLGLPALKDASALSHELKSFLHWATEMDAEKRPSAEMLAMSDFLSDPCSRASIVALLEEARHAEAQAAREEAADEASMEEQRSGSGGRNGSGRRDSWSSDSTTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDE0</accession>
    <name>W3VDE0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDE0"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="62301" checksum="4BACD64505D54FDE" modified="2014-03-19" version="1">MSSALKIRSDESSIVGTVARIISAPLHGLSMPTQLLLATVALSTAYMVYNLLVSPLARYPGPLSARLGIPFWRFWHTLQGDYAPALYALHQQHGDVVRIGPTHLSFSDPSAMNSIYSLSDGVSSKFRKSDLYRSFQVFKSHPSIFSERDPHQHSKRRRAVASAYSMNSLVKLEEYVEDVSELLLKRLDELVETQAVAADMSEGGQDAVKTRPVRIDPWFHYFAMDVVGELAFGQSFNLLHRGKDDERFLTGVLNLSQWGAAAGCLPWLSSWILWLFPRVTGQPGGSVIGDKTASRIETRYAEVEENGGMPSRPDMLTKFMEARDPDTKEKYTMKQVLFSASSVMSAGSDTTATSLTIFFGYLLDNPRCYEKLRREIDEALEAGALSTPVKYAKGAQMEYLQACIKEALRLSPPISMDLPRYVPSGGAVIGRNPHPIPAGTTVGISPYVLHRHTEAFGADAEIFRPERWLEGGEEGRKAMERFNMTFGGGSRACIGKNISLMELSKVIPEILLRYDLKKPAISPHTQEIESKSKQPSFQGRSCWFLEAHNLFVELVPRNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEA7</accession>
    <name>W3VEA7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06206</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEA7"/>
    <dbReference type="HOGENOM" id="CLU_010371_0_0_1"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="116"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="720"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="815"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="940" mass="103944" checksum="8C52D20A4AEACEA5" modified="2014-03-19" version="1">MAADDLDERAPLLARTASGGSQGARQRHRQADDELDFDARFRQWKAAVARKFRGKAHRQSEPTVLITHFDGLGQAQRILDAKRASALQNSRHEVTAMSSAEFQHQVEQVKHAISKCIYPKMIATGSSGSYFIRILSDPPEEASIAAHKTASNASQSQPPTTVVAVFKPKDEEPYGNLNPKRQFLRKYLWWAMGRPCLIPNFSYLSEVGASYLDSRLALQMVPRTELVQLSSPTFHYAYSDRVAYDEHRIPLPDKIGSYQTFLKGYVNASDFLRKHPWPSRTRSKTLLIRDMDEESRAHKVSRRKERARLRNCGVALKRLVLCRPSWEELNGDPLPSAPHPSASSPAPGTEVSASNSPVPDGAPTDGFSWTPKLMEQFRLQLERLVVLDFLMRNTDRGLDNFMIRHDVEKDEIKIGAIDNSLSFPIKHPNEIRQYPFGWLFLPSDLIGLPFSDATREHLLPILNDPAWWQHTTRGLRKIFEQDPYFDQAKFDKQMSVMRGQGWTLVQSLRAADEGPLDLCAREKKLIRQEVQEVSEERLEKIEGFKAAIDSEGHVVGTIKPSEQPSAANASTSKPSISRTISSGVLEQERRPIGIRASESYRKALLQAAETDAVANDIADLENESMLPAESGSTAAAISSSLPQSSTLFGKMASSALDGAERSPNERVPSRHQRMASANDVGSLSFRRADVARGSDEGDGILGRTGIEVLEGLDRERKRNRRRGFLRSRQRSSTISSSDAAATSQGRAQAGHGARKSSEDAGRGAEEGGWDLASSVMSDPGMRFDGTRRWPRSQSATRPAEGMVGSLYDLHSQDEVLSEEEEEGEEDDDAEYSRGDSVGAASGPSSPTFRRQVPTIDSVLQAHSGKTKGSPAATPDEGAGEGRGGAFVPHIPHPRSVGRTGYDADNADNEHRPKGDSTKRLVKVVVEKISSDTKQAWLKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEP8</accession>
    <name>W3VEP8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEP8"/>
    <dbReference type="HOGENOM" id="CLU_022730_3_1_1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834409" description="FAD dependent oxidoreductase domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="103"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="573" mass="61332" checksum="47729A7314BED62D" modified="2014-03-19" version="1">MRPGAMAVMSHQQLVLISTILGSPQIVLAQQPRRVILDDLPIPPSPHRVLEYVDISTIGIDDAPVTPSPLPVTSDSATVSYWMATTPKHQLPASLDALPASSDVVIIGSGITGVSCAYHLINSLSESNRPVCSITIVEARQFCTGATGRNGGHLTTASALSYDDIAANPAHLLGEDLGSLGDDAVRRKTGVAVRDILNFETATADAIRGIIADEKAEEQVGFTDDANWHICFEQAEIDAYEAALCHADKHADLKGYVDRVRRVPKDEVDRRMHNPAHIKAVYEIPGATLHSRNLVALIYARALRRATHHGITLNLVTECPVTTISAASSSSVLTTTKGEITASYVVHATNGYASHLLPQLANPARGGISPTRAQVVAVPAKAKTHLWGMALSSSEGFNYGHQRPRSEHEPPSADGPLYIMGGGRQVATGREWGIADDSTLSEEVSTFLHPYLANIFPESYGEDVHSEWTGIMGYTKSKDPLVGPVAGYKQGARQYIAAGYSGHGMTRAFGCAEVVAQMITAHAKGEEWVNSARFPECYLTKDAKANGAEPTYAEKVGKSDPDDEAAQRCCSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VER3</accession>
    <name>W3VER3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40s ribosomal protein s20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VER3"/>
    <dbReference type="HOGENOM" id="CLU_122625_0_0_1"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="122" mass="13683" checksum="6D293A7EB4DE6AD1" modified="2014-03-19" version="1">MSYVAKDKDVDASAPAAKIHKIRITLTSRNVKNLEKVCTDLVNRSKDKQLRVKGPVRLPTKVLSHTTRKSPCGEGSKTWDHFEMRIHKRLIDLHSPSEIVKQITSISLEPGVEVEVTILSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF63</accession>
    <name>W3VF63_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Winged helix DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF63"/>
    <dbReference type="HOGENOM" id="CLU_070147_2_0_1"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29795" checksum="E8BA66E8A5F1D4E9" modified="2014-03-19" version="1">MRRGPGLAALDRSLHSSTAYNTLGNDLTASQLTELRQQLDLFSTSLRQFSSQHRHEIRKNAEFRHAFQKMCYSIGVDPLSSSTRGAGGLAGLWSDMLGLGDWQYELGVQIIDVCVSTRTTNGGVIAMDDLIRRVTLLRTGTSTRTKTNEAPEITEDDIVRSIKMLAPLGCGYEVFSLGNGEQKMVRSVPRELDTDTMVVLSILLSAERGSDELPHLTEDALVSGPRARGWSRDRARAVLQNMSLTEGMLWIDEQCFPPRYYSLATLPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFE6</accession>
    <name>W3VFE6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFE6"/>
    <dbReference type="HOGENOM" id="CLU_005316_7_4_1"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="156"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="538" mass="59659" checksum="A09F4EC0BA5FD127" modified="2014-03-19" version="1">MADFYIRSATALDRVLRDECSVKAAASVHADSGRVLALLINALAYRSALLAALDAARVLKLEAKVFTILAPPPKSKNDKPKQKPVKKELKEVASAEAMCLVLCHDLLFQSRGIQANKTWPPKVALEKYRSSLHSALVKMQIRQGKARIQDLRSGALYHEMTARMPRWIRINTLRATRDEVLAWLAEHSYAQVEADEIGGVKEFAVSKHVQGLLAFHPKATSALLQTEMYRDNWIVMQDLASCFPAYILDPPADAQVVDATSAPGNKTSHLSAIMFAKSSRRIGQSEGRVVAFERDALRYKTLVKRLAAVGALAKDATTGNVIPERRDFLTTNPADFGDVTHMLLDPSCSGSGIVNRLDFLKEDDDVDELEDTVAAETGETKLQRRLRQLGEFQLLMIRHAFKFPGLRKVVYSTCSVHAQENEAVVIRALHSEEADKFGWRLAPRSEVIPTWPVRGDPDACGKEQGVAESVIRCIPGGKGEGDKPHVEACNGFFVACFVKHAPTKRPLEEEQDTPTGNSANRKKKLQKRRQKQRLAQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFH0</accession>
    <name>W3VFH0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFH0"/>
    <dbReference type="HOGENOM" id="CLU_1396909_0_0_1"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="191" mass="21377" checksum="D61B1A2E45A99A95" modified="2014-03-19" version="1">MTHPTFDNATFELLSADGKLRMRPVRLSDAPNLRDRCADPLNVKYLPHLQGKENQTVEDVEKWIQSVQAGFNKDSLFLVVEDTETNKVIGEGPLGYIDWNTKTAESGIMLDHQVTGKGVATNALKTSTDFAFKELGLNAVRFGTMKANKAMVKVIQEKLPVKPEPKHNTRKDGLEEVNFTFTRDEWLAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFK7</accession>
    <name>W3VFK7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFK7"/>
    <dbReference type="HOGENOM" id="CLU_389382_0_0_1"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="435"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="728" mass="79026" checksum="B1A95D73D7B9EA87" modified="2014-03-19" version="1">MSSQAPASTVVVTGINKSTARKQIDDFFSFCGSIAKLELTEDGPSTQKAVIEFVKPSAASTAVMLHGSSLDGAHLSVTLGASAASAATTAAAATTTGVPAAHDDVQSVGQEDKPKTAIVAEYLAHGYTISDEITKRAIELDNKHGLSATFKGYLSHLDRSLGQKLEKAAPPAAVTTERTEHTPSGPAALSSATDKVAAAMPVPGDDASVSGPKTTTTVPNPASTEAGAAAAALDKQDPSLTRQLQQRAQAVLDKPEVKAKTDLVWTKLSEYYNAFANHPKIHDFYTKTSKNVTDVHEEAKRIAEKRKQGGPSGAAGTSAPSSANKQMSVSWVLLGLVLFSSLSIHGVAAHSHDAISNEPAEVAGFEPTDIEHESYIQRHMRTEHHINAFNLGSAFALHDLDRNGVLDRSEIEAIYGVHHSESKKHSPTHEVHDEKADKIVGSVLRAMDTNNDGLITKKEFIDAGPNGLPTFPEYNIGSLGHHYDEESEFFVHHEELYHNTPETQSDESYTHKEDLEHFAKHDKIEEEEERRERKAEGLPSIEEDARLRKEAATRGEKYQSPYDEQLSPEQQKEAQKQHDEAQLGHAVHEAEASQHTFRTPSGKHIVKEEQMVFQDVEVDNKGRPAHPPPADASASSAGNQAANAEAAGQERLPHGVADRLPGETEEGRKQRLAAAKLEASRRPSYGHGDKGFAQPKDDSDRMRKGAPYKYPPLQKQFRVKKQSYFGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFS7</accession>
    <name>W3VFS7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFS7"/>
    <dbReference type="HOGENOM" id="CLU_090092_0_0_1"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="209" mass="23499" checksum="5A1D870CA3FD0E26" modified="2014-03-19" version="1">MSRGGRGGFGRGGGRAGGGGGSNMPPMGLSFQELNTLDKSPSKLYPEPPTVPRMERPDDKEIRFASYQLMYLQEQKTSAYWPVLEQRKQGDLTRFSDRYRPESQDLPSLKSINLQKEVFPKGLWDSFMEGETKKEELKAKKKARRKINWDSIDLEDRAGAEDDVGDVSSEGENQGDYEDEVDDDYAENYFDNGEDDDVGDDDGGEPAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG81</accession>
    <name>W3VG81_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG81"/>
    <dbReference type="HOGENOM" id="CLU_397494_0_0_1"/>
    <dbReference type="OrthoDB" id="3351822at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="558" mass="63005" checksum="9B97523E700D32F6" modified="2014-03-19" version="1">MELGDLEPSPLEGVHKLPAELLCHIFRLAASTHIPTAHACAFVSKKVCRWTAPDRWRTIVCTSLTQLDSLLKLVISDLDLEYSTLGRKPFISLPSEQPGEFVYNLFIETEDEEESSDWGIVAYRDRIDRLAKYDPLMYFRNVSYLALGDYEIGRLLQCSGFPLVRKLLVTYSDEVYLREFFDELDGTYQPPHSYDDGNSALQSIHVVAIDRRNKLSGLPMPIQLFARMRSGSISRGGYVSHFVDNIDNSPDYWIPPTDSEKWNTNVKIRFDTRKFAFRPCEITASRLKPFFDELTTDIGEASGGDQPLRPVTEAFSHTGPRHAAPHRGAGNQVIAQLNGRNQTTVSTPKREALARLGCGKFQKLHLCWDPLPDGEGTPSDESHRAGETDWPVERQDIWTNTVMHAKEARTQQSRVQISRTGCQPETRKDELTSRPGQKWVIPPGAASKDSASFKADMVDSIRTTLGWTRQEQELLSNTPLFSRDADLSNHFGSHERVDVLKRIVAAHLPPGAIDDPNEALAVRIVPPAERLRLGGYYVPFTKKQRVQWFLDNLDTDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGF4</accession>
    <name>W3VGF4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGF4"/>
    <dbReference type="HOGENOM" id="CLU_012941_0_0_1"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="649" mass="70636" checksum="C6E87850A34245BE" modified="2014-03-19" version="1">MSEPSTPRRAASGSSRSTTTPATPSTPPGTPGVAFVADDMDDPTSTPSRAPTSGGAGGAGGAGDDSDNEDEVPDYLRLLSSLQPRSKSSSGIVIPKRGEKDFEPTGFGGQSKLLERSRQAMYQAVSGSRTVGSRSLVRATWNPRSRRARIHDVQGKIFETVGVIRRTPTTDSTGKTVTQATNELLPEEALFLAERGSLQIYTQAEDSDALAPMSLQQAFAALMLASDEAADEPLTREAYLIYAHLKRLGYVVQRASIVDAVRAAPIPPSKARAQGIVADPQRPIKLVTLWDVLLYVPRRIAQLGADAARAVARWMQHAWRNTIGRVLALIGARFARIATSGSRKPGAVGLSLGLGGYDDVRRFLPHQASWTSYDDVFTSMQMVPSGHDFSLPLTSTPTAAAGEGEAGLKPFYYAWRPATVYRKSHPPAPEFRIVILNARTTPLPSVWQFGEVFAHIPMPGSDAELIASLPSQGEMGQEEFKQRVEYEKQLKAANDAKNRAAYGKFSEGKQKHLREKAAARQAAAANRAASNAANQGRLAAMLHTLTRTAAARWLWRLLKLDYEVLRMWARLFRHCPPGCWSDKARYQARRPQQRNNAGANVFPPLKAGRRSVVLAIVDGSITTLLRFGESEFAHWRLFGDAAPAITQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGY8</accession>
    <name>W3VGY8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05986</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGY8"/>
    <dbReference type="HOGENOM" id="CLU_047993_0_1_1"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="205"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="360" mass="39109" checksum="467320AA0B1D27D8" modified="2014-03-19" version="1">MLISLIGPPGSGKASVAHYLATRHGFEVLCTDNGTCDSLTALGLTATSCGDEKAMLDFVTDRWHERFVTLDLTTVSDMEAFIKRPFFLCVEVGSPLLTRWKRYQTKHKSLPLEKFVALDDEIAFGMSTAQASTRQPLVRSGSSAMGGNGIVDNLASVSISSPSAGLAALRRYVHVSIINDFPDRDSLNSHLSSLNLPSEERLRPCWDSYFLKLCNLASLRSNCMKRRVGAVLVSSNRIISTGYNGTPSGLLNCNQGGCARCNNTLEKGASGCGQNLDECLCLHAEENALLEAGRQKISTGQEGKGATMYCNTCPCLRCAVKIIQSGIRTVVYQLEYSMDARTKAIFAQAGVDIRQFHLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH08</accession>
    <name>W3VH08_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH08"/>
    <dbReference type="HOGENOM" id="CLU_350276_0_0_1"/>
    <dbReference type="OrthoDB" id="3366521at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="809" mass="88080" checksum="79FE369C6FBEB1CD" modified="2014-03-19" version="1">MSRLSRQDYHGYAPQAHPRWSPSPPLNRLSANVDLRMAPRLSNAAQQDMQPQSQTPQMASSLIPQPNSTLPSNADVVQAINSMSAQVTNQLSVMGTQLASLVSLTSRLIEISQMTLAANDSNARTANAPSSSTLAPATLGTQTLRQDASPATSNVDLNRTRVNGAQTSSFGLNNMVTNPPTNAPRTETRQGAFYPNASNTSSFRTTLDPVGSTLDRTFGSTLRGASPPTNTTMNNSLSAAAGRATQLSSQQQQQQQQQQPQPQHQQQQVPQQQQHHLQPQQHTMQQPSSAQQQQQQPADATHDANDLLKSRLPSPVFPDDPLDMSTDVSPPDHQASANAKRLSTAAQGVADSARKATADTSLGDWKAWLNRTWHAPPGYQSRPIKYRTMQAARRAHRDQTKRSMATLGRLPLKEFLEIRPEQYLSVRKTGRKLYQEWLLQEVRLAKQPEDRVKATINRLEHDHPELGDCEDHWKSRQLLQQIIDNAIDEANLHRKKEARASHVPNESTPRTTMDRSTSMLGLSASSSSSALADADRSLRGSDMSISSLRKATGGGAGNGAAASKNAKAANRRKADQAELDDTPTRFRQAPNQRASMLGPGGSDENNTSSLQTQQGSLSSAGLEAAHSGRSTTLADYSGGYNNDSSTIASTTSSDAMQASRHHAPHNQHMQHTQQTQAQTQQHHTAHQAAQQQDHTHNAWASQTAAPGASLFGQSNYANTATQQALSHHQQYGHHGHHHNSNYLSSDPGQTGLSASSSGLLDDQRHQSHLSPLVNSGNVRMHQPGAPTHHQQQHQQQQPANNFFDGRGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH14</accession>
    <name>W3VH14_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH14"/>
    <dbReference type="HOGENOM" id="CLU_008479_0_0_1"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12316">
        <property type="entry name" value="RRM3_RBM19_RRM2_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12570">
        <property type="entry name" value="RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="320"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="507"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="625"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="725"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="184"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="862" mass="93602" checksum="32E75C1990014C77" modified="2014-03-19" version="1">MSRLIVRGLPTYLTDARLREHFSQKGAVTDVKLMRRPDGTSRKFGFVGYRSEQEAQEALDYFNRTFIDTSRITIEHAKKIGDEELTKQREERMNKRKAATGQDSQASTSAHGLDASKGKPSKDDAEGVKKKPKKGGAISFEEFMSVMQPKAKRKAWQNEDAMPEQTMDDIFSGVEAVEKKAAKKAKKQAKAEAEAAAAAAATGSNSAQADADDASEPEPDAAVNDVGLTDEEYMRLRMKHRVGTDLDTQDDPTAPQFEQSDDEKDDKAVASASDSESDSDDEADAVNDEELERKQAAQRRKAEQAAERDQKIVDQIMESGRLFVRNLPFTATDDDIESFFESFGTVKQVHIPLDKQTKASKGLAFVSFSDPAHALAAYRAKDGSTFQGRLLHLLPAVNKDAPADTDKKAATLKQTRADQKKQDATKDFNWSMLYMSADAVASSIADRLGVSKSDILNPGADGGPDNAAVRLALAETRIIQETREFFSQEGINVDAFGTGAKAGRSDTTMLVKNIPYGTSVDEVQKLFEEHGEVDKVLIPPSGTIALVEMPVVSEAKVAFRALAYKRFKGGILYLEKAPVGVLTSKTGGDKVVKQAPIKGKTIDTSANPSANLAAGGADDEAAEGATLYIKNLSFSTTDDRLAGAFHGLSDYAFARVQTKPDPKRPGARLSMGYGFVGFKSVAAARTAQKAMDGKVVDGHTLVVTFARRNAESSTTASLSSSGGSTKILIKNLPFEVTKKDIRDLFASQGQLKSVRLPKKFDNTTRGFGFVEYTTVREAQAAFEALKHTHLLGRHLVLQWSKQGENAQDQVDMQREKTKSAFVATGDATANAKHAKIKLNHAQITSAARSARAANNQDDDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH83</accession>
    <name>W3VH83_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MT-A70-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH83"/>
    <dbReference type="HOGENOM" id="CLU_537620_0_0_1"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="55495" checksum="26CDC865E68C7DF2" modified="2014-03-19" version="1">MPVEAAQFRRARDHPRWPSLVASTAASASSPLPAEQRQQRRKHIAQRLGLALCPQSHTDDHNTSSSPSGAGGSALGPNYSAREATLRNDYAQHYVDTHSLPSNAVRNPDASTRFDEYPKLKRLVELKDALVTRAAHPPTFLHADLRPSLLPFRDPRTVGKFHLGSLIPIKYDVVLIDPPLEAYAWEATPTASTWTWGEIAALPIPNLAAKESFVFLWVGSGAGDGLERGREVLAKWGYRRCEDIVCIRTNADGAEVEAGSSVLTRSVQHCLMGIRGTVRRSTDVRFVHCNIDTDVILSRERDMQAKPQELYQLIENFCLGTRRLELFGRNRNLRRGWLTVGLELGPDSPQWPTNGLVPLPIPGLGMLQQDAHQDASLSSHLEQLTYAQAYDKARYDSAFGVDRPGCDLRDRINLVPFDDAVEALRPKSPPPRIRTPAHRGMPNGLSNNPALQNPPPHPTHPPPRTARGAGLSGLGAGGRRTVSVPSGSDTLSGPQASVLKAKSLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHB4</accession>
    <name>W3VHB4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHB4"/>
    <dbReference type="HOGENOM" id="CLU_002794_3_1_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="11"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="458"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="803"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="881"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1143" mass="126069" checksum="014EFDC7B88A2ECB" modified="2014-03-19" version="1">MATDGKRFSSHNVRCCTLIGHVDHGKSSFADSLLAANNIISARMAGQIRYLDSREDEQERGITMEASAVSLSVKMRVHDPTKGWDPDNLPPIQDFMINLIDTPGHVDFSSEVSTASRLCDGALLIVDVVEGVCAQTVTVLRQAWQDGLEPILVLNKVDRLITELKLSPNEAYHHLIQVIEQVNAVVGSFFASARMDDDERWHEEREKRIAARKQAKNDLIAAATGDDAADDDNDDNDREERDDEDIYFDPSKGNVIFASAMDNWAFRLERFAMLYAKKMGIQEHKLRKVLWGDFYFDPKTKRVLSQKQKEKERRPLKPMFVQFVLENIWSVYDAIIDNRDQDKIEKIVSSLNLKVHPRDLKSKDASTLIKAVVSQWLPLASCAFAAIIYVIPPTSKAQAKRIPMMLNPDMSYFDRGSYRAKTPLEEHLMNAEIGPKSNRVAYVSKMFAVKKEDLPEAKKAPLTAEQMRERAKESRERQSAVRAALAATGASMEDGAADGDGKANGTSLEEAEAQRAARAQREAEAQAEKDAAEEQEEEGSDEVVLGFARLYSGTLRVGQWMYALLPKYNTQLAPSHASNAKHIKAVQLEALYMVMGRDLLAVNEVPAGNVFAIRGMEGRVLRNATLCAPSLVQSYAIERHQDAATIDARTAASTFVNLAGINMLSAPIVRVALEPMNPQDMPKLVEGLKLLNQADPCVESLVQDTGEHVILTAGELHLERCLKDLRERFAKCEIQVSAPLVPFRETCVRAPEMAPPKLDGAPRGTVDGNVASGAVTYRVRAVPLPQPVVELLLANTQTLRRLQNRGSSAEGEDDSGSVDAAGSQASKTVRADKFWQTLQTVLDKCGQDRTGEDWREVVEKIVSFGPRRVGANILVDRTGGRTSLRNRTDPSRAATRQSSGIGTPAHADSQAVGVEKLSEALDQMDVSDDFGRTVVNLAALNESIDSGFQMATSAGPLCAEPMQGVAFFIESLSASSATGSVTGPLMSTFRESCKSALLDWSPRLMLAMYSCDIQASTEVLGKVHAVLAKRRGKIISEEMKEGTSFFTVGSLLPVVESFGFADEIRKRTSGAASPQLIFKGFEMFDLDPFWVPRTEEELEDLGEKGDKENVAKKYMDAVRKRKGLFVTQRIVEAAEKQRTLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHH2</accession>
    <name>W3VHH2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHH2"/>
    <dbReference type="HOGENOM" id="CLU_432865_0_0_1"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="4">
        <location>
            <begin position="312"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="591" mass="63240" checksum="18DC02C939BC91A6" modified="2014-03-19" version="1">MSRESSADPDPEHVEEAGSDDDELARELELERQKLLAAAASQTNANGNGDRSDSQEYIDDEEDDDEGDIGGDAAQDEDDSGDEWRPPEPAVKATRRSKRRRASSSSQDSDQSAAHEPSDDDLAPATKKPKKTAKPKKTSSAKSDEKVRKPKASAAGNASEAEANQDAEEYDSFDEEAERVQAEVEAAAAWADVRKRKQAAQSKSSANDSTTQPSAASSATKPSAAPSLTAWLGKGPSASSSVSELAASLPMPTTCAAAQIVDRSSLFVGYVYPLTTASSAYISALLSHLTRVVHPTVPVDLLPPQFANAPANKRGSSHDMYAYRVLELKRGRTGLAGPDDFSLQEDKEDDGERWGGDRVLRVARDEGASDVLVVVSRWYGGELLGPVRFEHIENAARAALEEHMAKEEVDEFRQRIQHLDRKIAQAKAGAGGNVEDADIVPDYADLTIERAQRLWLARQKALDALLKRVASQAQQSSQPATSQQDEQAETNTTEEQDEDPAGHSPQASEPEDIAASSPLGQPEAPAPDEAATGRPTASKSSQNPASTPAKPKSSRKPSIPLLRYASSPTQTPTQPSIQATPKSKPIQPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHH3</accession>
    <name>W3VHH3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHH3"/>
    <dbReference type="HOGENOM" id="CLU_1732260_0_0_1"/>
    <dbReference type="OrthoDB" id="10563877at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834515" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16016" checksum="75CA33DB2809DC5A" modified="2014-03-19" version="1">MLRAVSAPCFVLVWVRTSHASHRGAVAAQSGSEPALNPAFKLLPQSMRPALPSLPLPDARPRWAKTVEHSQMFSRMYLLIESRGTGPGGGKGNLGSALPIPDSSGAAGGSPEKPYVRKGIGSRLALPAVKRARLAKRSAPCQLHARPRPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHJ1</accession>
    <name>W3VHJ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006358_1_0_1"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1300" mass="140063" checksum="49C8FCC2E9EBC8AC" modified="2014-03-19" version="1">MQSHIYELGLLGGRCSDIRIRAFGRLYHLHRLVLIQSGFFRAMLCGGYAEDLAAASVAASLSRRNSQHGPQPPSSSSLHRDPDSDVVELHFDDPNISRAAFEYCVARLYGDGPKLVLPFWATPSSDHPFSPALTMRLSNCSDLQLPNLVIDRHSHPATPRFLLSLLATSIYLNIPSVTSQALTLVLCSVTPFTIIHYLRFAIGRGIEGTDLHRSASDVMLHDLDEWDWELEGPARTLDELARFDPSFSSSSRHPRTSGVHERANSVSDDLAADLDRRMHVSPQSPSSKHASTPPHANAPGQHDRRASQPVHGLSPPPPPSGREHKSKGKKTPGFRDCESSPPQRAPGGLLPEFNYGITADKIGEACVCWFARWGYDIFELECSMERERVVEIETWIRMCREDRDLARLTLLRDRLHTGDVDLLHTSMLARGRMPDPDERLPSPRLRVWSYPSMPSSWVRAMISSDGFFVPSELHRYEFAKKVVEFRRKQKALINVLDRLIEDWLRQDQHLTAPADNETPDSSKKMGGAPKASSSNASSSDAGDGFGFKAFRRAPSIGADDEQEEASTPLQEAWDDGVESTTFSASLDDDEAEYEELFSTGIYYSHMPFQALNKISADISPTTGRPYTPLNVLQAALWVSNELRTQVLNSAPAGGKNTAASNQEVEPGNEAGADSGPVDEEAEDWDHLNALGVSSSIHQFRDAFQSTIQSTGSQHRFSRSRSGTPMNLSINPDGSLHSGSSAALGGLGSSPLMSGILGGGTAGLLNKRFYLVPSDDTVRFGDSLASVIGVTTGGSANSTKARDSDDERKGKSHAFESDPNGPSGTAAMQIPHTLPIPGVMHQDINNTLHQRRHRSHYYGIANDVATGRELGEYAYRHLPAVPDSSSRAASRHVDERDAFDSAGGEFSSHLHDPNQDAEGADADSHGSADVSPQRWSGYEPMRVGVEFFGIDKLQEKQRLYSPTFFYAGSVWNLYIQVVKKAKGIQLGIYLHRQSLTEQLPPPSAPTPEEGETTPGLATETAWPGAPGGARSTQRGEPHGTPSREQGAAPGQRSVHQSTRGSVFGVAFGDESLVGEGGSSFVDTSLTSPIRVGGTGYAAGAGSTLTLPSGRTLTRLGGNSAGSPMRNSLLDPFASAEAEGSRLSTEGGSLASLSSLGEFGASLTRDTTAAGAGSSPAGGAGGDESRSRHSTGTQAGGGAARPPIVELYAGGPSVYQTCPLPPVPYRDPRIELRAYFSIHCPSPLGTALTKFSSGPDRFTVSQSWGWKSSSLLGTVHLENGDLASGRPGLSYRFRCVCSIGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHR3</accession>
    <name>W3VHR3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05169</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHR3"/>
    <dbReference type="HOGENOM" id="CLU_262469_0_0_1"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="1196"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="513"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="598"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="719"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="915"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="953"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1146"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1162"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1238" mass="131581" checksum="3497985E511DC413" modified="2014-03-19" version="1">MGKRGHGGGGGGGGRGGFNRGRGGSRGRGGGGGRGGGFQAFEGRGNVLGGAPGTSSSSGYNSPRGGSANARGFRGRGRGGNLAATGQNRVGFDYSALTRGRRAADGDDDDDDDDDSDEDDFAIEPPAGYRHKVKPHLESDAHSDQEKPPAKNALHAGPSTPLRPRDNFAGPASKPRFTPRSNAPTNFPEFYTSRGAHGGAKFRPPEETEDAKYLAGIPGLRRPDRKQRDRPRFGDPADKAQSNFRVPVAFVKATGEFGDPLKGNLPPRDPNEALSDPNSMQQQQPATNPGERHAGLGFSNRSQKPPGAEAPKAPAPAPASTSQPSAAPYAPARAPVPAFPPPTLDAFDFDSLAANNAQDHDEVDALLAAFPGSKELAPGESMLEDDPTASWTLPAFQPHDATAQRVSPSAAQLPSRTAISSSSSDDEEIILVPNSAQPSFDTAPTLDVIVEAKAVEAVESTVAVEAVEQPAMQEDLGFVIDLEGEDPASLASNSEHVSATSSSSFRVALGDRAAADGAKTSRSRKKAVNRRGKPHRVPREGDSDLDWGSDGPPGASDNDTADEEGLAAAAAGISITRTNDTNGITDPILAKAIRADRHEWESDDDDDAQFSKQSKRRGGQRAKRSQAGRATASRSAARSRKADQDAIVADYMQNLLDQAQGDPDSDQDVFATDDMVVETVDGELPDGAAGKGKSKAKARRLSNKLDEKTNLDAMIRFMNGMDPQKGGRQLGFGDIEDEIHMDEVKEWLTESEDDSDGDQDHQAQHTEAAVSIEAEPKKEVQRATASDNDDEDEDMAEQLRQILEDDNDDESSEIFSESSSESSDDDDDDDDDDDDDDDSDSDDDDEGMFRGKQSWADEDEDFIRALSSQVGGAGIGSRGGAAPSSKRAQKKLFHAISNGDFSDLADLAAAENEIDSDDPAYGLGSIPTARNGKRKGRKFTDDDLWAEQLQQQWDKDRASKASKKQQRLAERQAAALNPFPNTHGKAGSGKTKSTKKMAKLARKAEKREMRASLKAHSNNVVAAIQAAGSVDAVDASLFTFGGKSSEMSSLGLEERFAFNMDELNQQIQLFLQQRGRNTMRCQPMDKFARAEVHALANAYNLQSKSKGKGRDRFPTLIKTSRSGLNVDWKKVKRIVWSNAGATFGNDAGKSDFRDKNKRKGKGASGGGAGMYGVGGGTVPKNREGEEVGFGADKIGADNIGHKLLAAMGWTEGMGIGSSQGMANPVSATVKTSRGGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHU0</accession>
    <name>W3VHU0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP complex mu/sigma subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHU0"/>
    <dbReference type="HOGENOM" id="CLU_061221_2_1_1"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14834">
        <property type="entry name" value="AP3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027155">
        <property type="entry name" value="APS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="98"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="255" mass="27282" checksum="6477467464C8D711" modified="2014-03-19" version="1">MTIRAALIVNNHGKPRLTKFYTQLPASRQQALIKEIFRLVSKRPDGVCNFLDATELTALLPPPADAVRFSSALGGSKGKQVDKPAYNTASSSSASSNNQDQLRVIYRHYATLYFVFVVDQSESELGILDLIQVFVESLDRCFENVCELDLIFHFDHVHAILNEVIQGGLVVETNINEIVAAAHATARARKASAATAGSGPAAAVGNSLGSLAPAALNISLPGTSGSSIPWPKGTFMVDAISNLGNQYLGRSSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHV1</accession>
    <name>W3VHV1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262152_0_0_1"/>
    <dbReference type="OrthoDB" id="2555912at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1446" mass="145007" checksum="5D35A79CEC792FF3" modified="2014-03-19" version="1">MATLPQQAPGPGPTAQALPSYLSYSPVATSVFPYTSIITQVVYDPQGSFAPYQTLSTVQGVSTSIDYSVVNVPLLYTGPFPAPDLGTLYTTPGQILPTPTTAAPTQTTAAPTQNTGASPSQTDAPSTGTNDPATAASTDQGTLTAESAPPASPTATDNTASATAGATPSSDTSPTSAPANTSLSPSSTPEATTPPAPDSSGTAPTSTGSPTGTTSRQPSATAAGAPNPGVRAAKGLSGRQIAGIVLGAFFALLLLLLLLLCCLRRRRNRQQQQTVLAAATGGTGTAEKSGASGFGRGASVRGGARGNYAALGTAAGAASAAGLGAAGAAAAGRRGSIGSDDWEEDHLTSGGAGSGFFVVGGKRLGPNRSASIASRRSRRSSAGLGPSYTTANAAPSSRDGARKGRMAALAAAGAGVLGAAFGSGKKNKARVELEEEQPLSDEDADGSMAERRGLMPLHDSPGSGYGSGPEMREAGRHGSGATAALLGAAAGAGGAAAVAHRRHRNGSGSESISPPRAYGGAAMSRPASSAFSGASSGGQASSHATGGTTSSQTQRAGGAAMSSSNSTGGFTTSGSGASLPPPPRAPRGSPQAVASYANLEPSSAPAPSLAHDARYSVDTTDSNASARGGLNAALLGLGGAGALGGLGALAAGHRDSSTLSPDMRASHASEMSADELRHLRSTDPERYSRFISTGSNLLGPDYQPSPDIDSEDKQLGGADALAAGTLGQRTRLPTIRSVGEFGEKSDSGSQRGTGTGERTGSSQPLSSLHAVGANSGSLGGGSTGSRNVISPLPVYEPHQRAGETLPHYTLHNQPPQQGLGEPKQIQSPISEGQGRFVTPPDSPRNTLGGAMSVRSGGRPSSEVQRYADAEDSDLGERGVPGDDEGRAELAGAGIASAGIMGGVAAGWRRLTMGQYAWMPGTTAARGTQAGSYRDSSGELNDAEGRYSYEHNARPSEDSSRLQHQRRASRLEPSDMGLSDVRSEHASVYGPSALGHATSTSSPVAHLSSKEASGSSGEQAKGSGEVAGAAALGAGLGAVAARQRSYPSVSSRGGGYAASQSNSSVSRRTGSDSTGLDSLSAVAQLSSRSTGSASTRSGFRSSSRGGRSGGMSEASMGSGASTGAASYSPSGMLSRGNTTSTRDMRDASAPTASATYYASRPSGDAESLMTDATDARYADADVASSMATQGGASSLERRKRPRSSSVDGLSRLDSLREVREASDPFSDAERVADTQQGGHYPSASLGAAVSRSVARDLRQERSSPGEATDSSFLQSQPLPQRSRIRSLQPGTAAPAPTALAPSLSTPSLNSGEQAGLPASESDKTMPSLGSTNLSAVPASASWRPSPRVASASQRAAEAQAALLRAQASEAGAFGGATPPRSQAASPSGADARARGASYNWADLDTTFRSQDRADTSADVENSAGDVPNDTDADRSNRSFDWPKFLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHV9</accession>
    <name>W3VHV9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_05120</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHV9"/>
    <dbReference type="HOGENOM" id="CLU_005965_3_0_1"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000720">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000056">
        <property type="entry name" value="Putative Hsp70 family ATPase KAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Matrin-type" evidence="15">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="87"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS61164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1070" mass="114986" checksum="D31E1B5E90A281A1" modified="2014-03-19" version="1">MADVWISRKKWTCKYCDVTINDDLPSRRHHETGVRHKQNVQKALQDLYRKSDQGRKDAEQTKKQIEQIEALAAASYAKDQAAAGTSASATAPSATPITSPSAAVSSSKASTGTVSKPTIRRPPSSSAQPEVRDVQPVAEAGQWEQVEQAQPAASSASTFGPQSTEATERDQARSFRVREKVGRLDDSDDDDDLGARTIKVKKRPRTEAAAEPRPAPGLTRPEAEHTHTPAAESSVSVKKEESGDNVPADSRQSDADGADTNTASASNGGGGLFKKRRPGAGAGTKRQRLVRAAAAVRCSPAAPSTSTRTGNRSFQLTWRTRTHKATLLALAILSPFPHHQPCHRYPALALSPSSPSPPVAVTHSLSEVQVIMVLASRTTAVAQRRKAARATGLTRPAFMTIVMAIFALLTFSAFMAPGSSAGGMGVAAATDKRSEYGTVIGIDLGTTYSCVGAQVNGRVEIITNDQGNRITPSYVAFTPERLVGDAAKNQAAQNPENTIFDAKRLIGRKWGESDLKKDAKHLPFKLVEKNGKAAIQVNVNGDKKTFTPEEVSAMVLQKMKETAEAYLGHKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDKKDGESQIIVYDLGGGTFDVSLLSIDSGVFEVLATAGDTHLGGEDFDNRVSDYILKQFKKKSGLDASFKKKSGLDASVNKRSVGKLKREVERAKRTLSSQMSTKIEIDGFFEGNDLDETLTRAKFEELNMDLFRKTMKPVEQVLKDAGVKKDEIDDVVLVGGSTRIPKVQAMLKEYFGREPSKGINPDEAVAWGAAVQGGVLAGDESLGDVVLIDVNPLTLGIETNGGVMTKLIPRNTVVPTKKSQIFSTAADNQNTVLIQVFEGERSMTKDNNKLGKFELTGIPPAPRGTPQIEVTFELDANGIMKVSATDKGTGKAESVTITNDKGRLSPEDIERMVAEAEEFAEQDEAVRKRIEALNNLQNFIASLRSQIADKEGLGGKLDKEDKDTIKQSLKDAEAWLDENSQTAEGSDIEEQLSELQAAVAPITAKIYQGGAAGGDDEPLNYGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI62</accession>
    <name>W3VI62_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_05346</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI62"/>
    <dbReference type="HOGENOM" id="CLU_060552_0_2_1"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="102"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="293" mass="33404" checksum="29646FB9DADECD13" modified="2014-03-19" version="1">MCALLRTHPLDPSSVTTHIRSYFRLPCEGRAANMSSTTTSTTATTQTAQVGSISLDSSLAGYDEEQIRLMEERCIVLDNDDKYVRDGSKKECHLMTNINKGLLHRAFSVFLFDPESGKLLLQRRAAEKITFPNMWTNTCCSHPLAIKGELEEAEQIGVRRAAQRKLDHELGIPAEQVPLDEFQYLTRIHYLAANGQDDIWGEHEIDYILFITANVTLQPNLNEVCDTKWVSPEELKALMTELDPASFTPWFKLIVQKFLFPWWTELLARRQAEQPLDAKSLADLTDHSIHRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VII9</accession>
    <name>W3VII9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VII9"/>
    <dbReference type="HOGENOM" id="CLU_2097860_0_0_1"/>
    <dbReference type="OrthoDB" id="10446610at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833007" evidence="2">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="116" mass="11541" checksum="A7FC21D8AC38BF98" modified="2014-03-19" version="1">MGRFNSAVGLFGLAALYVYLGGVSGTPARPFVEGTAATTATTALDSPIAMSMAPYVPDGAALFFGGAAAIVIVVNLTCREPTFVAIPYQRAICSASAATLLLAGTAAIVVGLAKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIM5</accession>
    <name>W3VIM5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIM5"/>
    <dbReference type="HOGENOM" id="CLU_013929_21_0_1"/>
    <dbReference type="OrthoDB" id="2556734at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="518" mass="57997" checksum="D318E44F0039C92A" modified="2014-03-19" version="1">MQSLSPASKTALVEYIQRCSCSGFLLTPAHVRSYANTIARPVPGQPGPIKVGQGWIRNFLLRHPDIKLSWLRCLDNARLKATDEAGIRSWFDRLADIFREYGVASTNILNMDKTGCPFRQTVSERVLVPDGDQAARFKLQATNREMATAIKCIGSGGQVLPPLIITRGKVHTVGEHRQMEGVPTTWHFAKSANGWTSNELAVQWLETIFDLNTRPSLPSKWHLLIIDGHGSHVSTKFLDACWTRRIIPFLLPPHSTHVMQPLDVSIFGPLTAAYNRRLNDITPHLVGDIDKARFATIYAEARAATMTSTAARKAFTDSETQERPLKPLPAPKSNAAVDYALDNFRQLTDDKEAHRLKWAIMEAYDAPYNTILVLQSENTMLRAEQERIKLATRKTRTRPKKGDLRVILRKNMISCDHAERELAAKAPVAIKDDHRHHLDEEEHDIAPPTASADDGDEADDDGDDDIYAALDNPPPPYPFTPLDILDAIMPFDTINDDDSYSGTFWDEVPEASSSRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIP2</accession>
    <name>W3VIP2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sedlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIP2"/>
    <dbReference type="HOGENOM" id="CLU_085828_3_0_1"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="24207" checksum="F5512C4DA9A23CB8" modified="2014-03-19" version="1">MRACAFSTIYSARLVVFAASGFLTMSYYLTLIGTRDNPLYETEITPKTASTSSTGSGIFSTSSNAGAGAGGGAAESGSGSGMFGGLLSRIPTTGSALTGGSSATAGTSGSPAAAQAQSAAAAKRKQRYELQMIAHSALDTIEDALITSPYLYLKSIDRIQEYTTSCFVVPGNVKFVLLHEHKHEDGIKSFFLELWEAYLKVAMNPFQDANAPIDNPTFDARVRAAAKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIR4</accession>
    <name>W3VIR4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIR4"/>
    <dbReference type="HOGENOM" id="CLU_034867_1_0_1"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="106"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="582" mass="64140" checksum="0983FBD07E102188" modified="2014-03-19" version="1">MSEAVSASSSSQGAAAGGKKVKQSKRPSPEEIEAKRRERAAKKEKEAADKAAKEAELAAAIAANGKIPNGHLNEHGNVLFVPRDWASVSQAKEKSASAKQKVRVVSWNILAQGLVRRTLFPGSDCLKFKDRSVGLTAEFSSRTGHGWDVGCFQEVDRMDVHGETLDKDGFSYVYEKGYRQKQHGLLVAWRRDLFGESAHRRMTIDLDAESVAAPSEPVRTACSRVTRNVGLFVALTLRDSANGDARDKPGIVVATTHLFWHPMHAYERARQSGILVRRLHEFRKELGAEWQDAPCILAGDFNDQPHSATYHLLAGRKLTPHCHEEVSMSSVVHKSIDERRERGGVSVGFAEGTTEVARNLPSTKAVAPSTDSDAVEEQDQQNAEEDAEEQGEEEEREEEEAEEEGGEPDDRMLKNCRAATKEDALLSMDELLQLHDVARPRPGSADTQGDPGEGTSAHLGSAYGLHYGHISDPSEEGNFFGSPERGRERWDDPDWTPETPNCHTGDSTEPMWTIFSSLFCLTLDYIFMLPKVETSTEARAVPSYPTVTRLLRTHRTETLQPGVPRKGVCASDHIAIGAEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIV0</accession>
    <name>W3VIV0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIV0"/>
    <dbReference type="HOGENOM" id="CLU_665979_0_0_1"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833020" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="28"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="117"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="424" mass="44962" checksum="ABA050E054456A01" modified="2014-03-19" version="1">MQDFKMLSTNVLSAVPLLLATAWCVGAAPGALRGESGVSVSDIKLGYEHTVARYANWKPDTAKPAGRGRGLFEDFKLAAVSDASANDASAIAVVRKRGTVLPLHAVGGYPKMLGVTYNAEVGMGTPTQLFNLTADTGSMLTWAVLASCKDTDCPGASTKRKYDPAASTTSRVGRKDHEAYGDGEMDLTLYSDVVQLGRIKIDATVGGANKTFERDGKLDHDGLLGLGRKADADPAPVLDSLARERRGFQETIALDLGAQPTLEVGGYNYVKYPKMKRYTVEGDEGWQLEGSSITAKGADKVDAINLLLDTGSSVSMLPASRMDAIMNRAGLKVQRSKDEPIVYSMPCDTKLGVQLVLPDGTQVDVDDSDILMRSNDASTPGCLSLLVGTTNPFVPAVAGTPLLQSLYTVLSRNPSGDWIGLAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ11</accession>
    <name>W3VJ11_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CLASP N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227135_0_0_1"/>
    <dbReference type="OrthoDB" id="3013446at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="7">
        <location>
            <begin position="1801"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="783"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="915"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1278"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1683"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2127"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2166"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2295"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2523"/>
            <end position="2697"/>
        </location>
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        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="161"/>
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            <begin position="357"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
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        <location>
            <begin position="537"/>
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            <begin position="1028"/>
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            <begin position="1319"/>
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            <begin position="1345"/>
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            <begin position="1445"/>
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            <begin position="2171"/>
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            <begin position="2295"/>
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        </location>
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            <begin position="2360"/>
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        </location>
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            <begin position="2523"/>
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        </location>
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            <begin position="2544"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2616"/>
            <end position="2625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2735" mass="289181" checksum="5E7F8CC8786B6D2F" modified="2014-03-19" version="1">MQPIQPTAAPPQWAQISFDDGFDLNLDATSSLAGPASTAPSIQSPAIPDRSIPDAPQNRFSASPASSNKALPQLPSTATAMPASVGVPSTVHARLPSAHSQDAATATTPKPPGTPQAHLHPSPIVTAATPEQPTNRNFDAIQPPPRPVSSADAYMHPIETLQSDTNSRPGTAMSNLSSANGINPPTTNRSSFGTATTSTTTNAPFNQPKRASVLSFQTANSAGFTSADEAKSSDREHLADQTLVAAPATSSALPIDAAQPIRPWLDRNTSGYGSSPDERSFPGGLPGSFWDEPVARPPHTTAVLPEQPAPQPFLAVCPPAPPNHNPAAAAPAHADDTSSTQIGPADASLAPINTHGLAPSSPNAPLSSTTIAAPSDETTQAARQSPDVAKASVRELEPISDLDAPPPPAKDARIDDNASPAPADNLIPPPLPTDAAANAQPAINLPALQRPVSDYRKKPLAHISPAQKAAGLAHLQSQAKAPTKQPSRDMPSNAPPTAPPTEAPPIVMMERARRKSTASLTANVALAQAAAGVPNLAQDGLADTPDTPSAESASAESSAPPDGEVEARAEWERRRIKRKNGNKNKDSQTQNKGRSDTFKSQLRPLQLVPADNVTAFSDRNAATADRHSIAVANRTANAIAPATSDAPAPAAAASAQTTYSTQQLQRLQAREQRRSVGAFSAAMAAANVVSSGSNGPYPVFASPNSGPQKVGARQYPGLMAQRSLVPPFELQHRPDGLPSGMIGPDGVRRSINDPEVCLECMMRDEDMIDIRVVGDGVWERESDKDFQEAVRQEAEDAASGPASHGMSGSSGHADSLTSHRDSRQSRKARKRIGKGEPLTVERLKLHTQMNPPASSFRWRTLQTFLAVQAKYIAMEQQRMRLEVDKRARHNNDSVSSRGSFVADSPVAAGVLSSPFAPARDASSPQRQSILSTSVDDSTLTPLQKQEKERDVAAAQAARKKMTVGTTPPMAPTPPLGMPAYSVTPLQTRAAPQSIPARVGSDPDGVLGGASPVGGVSMTPSSSRRVPFASAPTARAASAQDLRSMADGQRSAGYPASPDSLMPPSRSVMGTSPTGTPSRLAARSGASQLSLMHSGSMIDMHVAQEDRAEHRIKQNGFLPGTPLAVESPAAMNRSYYGFPGDGDSSLPDPAAFERSRMVSGDGYVNPMQAGPRGLDADHDDNKRKKKGLRGLFSKLTGGSAAGRENSTGGMGDGSINGSVASRNASRRSQASDSSKPRKFSFSAERSLDTSGAAASPNGMLSRAHRSTSTFFRNGAEPDVEAAKPRQPSAGNSNTPFQNPPGMTSQGSLDLGPFQPASPQANAFGAANGSAARMRKASNPLMQKYLSSPSPQTQASPVPSSVPTSPVERVAVHPSQRDARVSGLQPIPDGEQVGDEYEPRQSVRSSGSASVRKELPAMPTLGGRPSMDSGGPQRPPRNPRRPEGALNSPSLVDLSNNGGGVGQVRREFPQPSRYESGSYASVASRESETKRSRFRLPFGRKKRESTLGEPKPSIVVGGAEEDGVRGGLFPALRTRKSYGGLGVPKASFSTERQRVLSSPSHDMATLPPRSQSAFGMAPTQRFMSMDLPRRSMNVGRADHRLSTVGYEEEDEDDEMEREPGYEAEFNRYAQEAAEERYVKPREASAGGQSFGRKSLNLLRDLRMPLGLVRAGEADRNGSRILDTTTRHLPNTRRPGTLSSTTHSLDPRAGIRSTAARTHRTAKLCNAAHPSTTHDLHKGTRCTLAIHDRTNSSYNRADDIQDQDQLASQHIAHQDSRRLHRPDMAPKALASDAKIVVASTDELQAHFDELHADLHLAETEHTWHKIEQSLLYIQAITRGGATKFADFVPLIKDAAAPINGALLSERTKLSGTAADVLNSIAPRLAERFEPLVAVFVPTLLQICARTNKVAVKRAEKSLHFIVKHCRPVAVVPLLREALRDKGSGLRAVAAGTLVAVLECTDRDRLGRRVADVEAAIRSGATDSNAEVRQISKRLFEHYVALWPEKVEAFTKPMTPTIRRYLALPKTGALVVDVPTPQLKVQEAVRVAQPPPPPPPTTTQPTSQYNFFPDLHRAPAASTSRGFSVNDATYAKRGLFADQIAAARNARLARMPSFNFDDRLVDAAATTAIKRQPSLEQRRGDINSSTPGFATTGAHGKSVLLAAYKQAFVDQHSASSRDKSRDRERKHADRKRDKTVVRFERDTLDAPHPAEDEMRRSKSAPLIPAAEAEVIHDPSTPTESGEDRPITPPQRVVQTPRTAVKASRVPAQRVAASAVKVSAARVVVPTPSAKVAATRVVEAASVEASPVPKARQAKTPEQAIQPAAAKPSDDKDPKAPVKKAVPVPSTTPREAIKASKSTEMAKIASKPVARPAVKKAVPTKPAAPAKPTTTTAPAKTVRPVAVKPPAPAPSSAAMARAKLAAANRLASTTTAPKKPEGGGVRISTATASTASTRNKIVPSAAVKKFTPKATPAVGVGVRRAKSSIAESIAAKSKIVGAQQKVSDKTVAVRKARVSAALKMQRRASAVAATKVSTATSNAASTAAPTPASKREEAGQEEKKEKKIVEEKAVVGTPMQSPIKTAAPGGSTRTPLGAKDPNVPSTRSTPLKSPLRPTPRSVTALRVLDVSVVDSRSERPTPLVAAPRVLDVEVSDSESDDTRSTRPTLESPLRSTPLRSSAPRMLDVNLSDSESESESGGEEVVQLTLGSKQLVLGPDSASSDASFGASPDDETVVLEAVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ16</accession>
    <name>W3VJ16_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ16"/>
    <dbReference type="HOGENOM" id="CLU_047036_5_0_1"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="151"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="317" mass="36798" checksum="42C1808ECFB8E119" modified="2014-03-19" version="1">MEFVSQQFNSTVGSLLNPATTHLAADLYKNTDLASLNVFEKAWADWYLYWGNPVLATGIMSFVLHELVYFGRAIPWIIIDAMPSMRKYKLQDDKVPTPEQQWKCTKYVLLSHFTVELPQIWSFHPICEYFGLATHEVPFPHWTKIAWQIGLFFLFEDAFHYWAHRALHWGPLYKHIHKKHHEYSAPFGLAAEYAHPLEVLILGMGTIGGPFMLCAFTKDLHILTVYIWIVLRLFQAIDAHSGYDFPISMHNWIPFWAGADHHDYHHQAFVGCYSTSFRWWDSFMGTDLSYKRARARQAEKKRQALEGSAKAATAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ18</accession>
    <name>W3VJ18_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ18"/>
    <dbReference type="HOGENOM" id="CLU_107716_1_1_1"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="85"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="205" mass="22941" checksum="56D65A0469996574" modified="2014-03-19" version="1">MRLSVPPARLFSSSRYLASARSVHTSHPRPASTPADAQRAQRLSELRRKFSQPAPAPAMSFQPLYKYVDRDTLAETVRTHAADPAQREVAIVDVRDDDFEGGNIKGARNHPSATFADEVQDLVCGPLKEYKQVIFHCHLSQQRGPKAAGQYAQARQAAEADTEKGKLPEQQVLVLRGGFSEFQDKYKKDAAVVEKFDESSWQFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ48</accession>
    <name>W3VJ48_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_04735</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ48"/>
    <dbReference type="HOGENOM" id="CLU_311726_0_0_1"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="79"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="238"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="602"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="692"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="784"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="373"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="484"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="851"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS60822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="908" mass="92946" checksum="7C8B53C124A78D5D" modified="2014-03-19" version="1">MSATASRRGSFPRPKGRSNQQVQDDTEEVRNLRAKYSDQLAMIRELFPTWTDEDLLFALQESLGDVENAVVRISEGQVEQFSSVKSKKHVKKESNIHHAAPAPHASAPPTTTAPHAARSNHIGAPAGRGRGGASVRGARGGRGGFRGVGGRGGGIAPQTNGHDVKTPETVEATTAQAFAPIATPTTGTSWAAALGRSNNKSQPAPAAPAAPAVPAPAPALVEESSAASLGAPVAPADTAAAPAPAAETVAPQATESATTTGALSSSNDKPVPAVKVPAPSKPAPKAAGMSWAQIARKSEAPKPAPAPAASAASEAAAAPSAETAAAESATAAHIESAASVQPDASAEQPAPDAVEAAPEPTAEPVADVKEDAAPAPAVSESVASEAAPAAESASAAPAAGPPGLSKAAPRAPAQRSSQRARQDAPVVMAGGSSQLDKLGVQFGSLNFLGGDAEDAAETAEETPAAAEPEAAPAAAAQTAAVPSAQRQDAQVGQAQTESYNQQPASAQYNGFKSDSFDNSYGFTGQQQQQQQQTTPAQSAAQPQQQQQQAAQEQIHGYNGYNSIGQGQAASQPQPQQGLQDYSSMYGGLDTQRLAQFYGAYDQGSNAFGQRSDDKSQQQASQQGQQSQQQAGSQQAGEPHQPQHHQGHQAGPGLQQAPQQQFPGIMPYYYPHYYMPNQFQHYAQPTAGYGQYPVYGQPAGQPQHPSKPGTPANIASPYSQGPQSDASAYGAQNHYGQTPSSAGLASYDQGFGRGMPGLGGMSDYSKIYGGAIPGLGGFLGSGAGGAPPSQNAASGNAGSGNAGTPHMGSQQKSGASSGSALDSYRQYDANASKGSAQSGAASGQVGRGQGQSQGQPQVQQQQQQQQAQQQQAQQQQQQQQYYQQYGAYGHQASSNAYSNYPYARQYWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJD5</accession>
    <name>W3VJD5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04127</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256282_0_0_1"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="14">
        <location>
            <begin position="635"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="400"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="521"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="674"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1124"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1240"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1297"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1406"/>
            <end position="1511"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="95"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="116"/>
            <end position="125"/>
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            <begin position="225"/>
            <end position="235"/>
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            <end position="258"/>
        </location>
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        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="296"/>
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        <location>
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        </location>
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        <location>
            <begin position="411"/>
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        </location>
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            <begin position="556"/>
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            <begin position="592"/>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="680"/>
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        </location>
    </feature>
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        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1146"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
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        <location>
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        <location>
            <begin position="1358"/>
            <end position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS61635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1511" mass="157668" checksum="129E2C1B90202FE5" modified="2014-03-19" version="1">MSGAAPQTASPRSSSYGLPLRTIPINESPSASASTANQAHAQPQPKRGIRVRVNSLGATMLLKHNAATPTDHPSSSAMRSDSPSANATRSRSATWRSPDPTPSSASVSPPPQPHSATPSTSNSGFNRRKFFGRSNSIRSLLGGVGSSNAASSSSAAVSTDAAAPSPKPNPASRPSSASSPASQHPLGLLRRMGSKSFLNLNQSNQATPANPSSDDASSLASADSEPSKRFSDSLKRIGRRRGKSVSTNPRSSSSQSSSDFQPGRLTHSELLPAHDASRRSIESARSSTASITTTDPNHRHSESDPVDSRPKHDSRDLHQSAPRRLTGWLYNMVGSDNSPSPLEQGAPLSPVREADINEVMAQASISPSKHSRDTSANAHSSDSIPSRSKAGALLHSWTTVGSAKHPRSPQASTAETTQSATLTASQTVTTLATTGTNSATNTSGAGAGSNSGGDASASGSASGSGIASTSSQAGGGNAANTSSWVPGGVGLDRAFKFFLDTDPSANQDEGIWLLGVWHAPRQSQKSEPPIAQEPRSATRAVASDAADDDHTDARRAASPSSSVSASSPRRGPLDLNYASFAPTSSSNQPDRTTVGSSISTGATASTAESLRTRSSATSFNIASSGPTPPASESQSAFQPDFASRIWCTYRNHFAPIARDGTISDQAASAAEALAIAQSQPSDPATPSAQAGASSNPDPTRSSSPPASASRGWLGRKTAESNVAHEAAPQASSPLGLGAALGAGYVNASATLGEKMGITNLWSRATAAAQAAGFSRAGLTTDSGWGCMLRTGQSLLANALINVHLGRSWQRETAPKSQIEFFEELANASLDASAENQSLASWRERRARHATYIRILSWFLDDPSPACPFGVHRMAREGKRLGKEVGEWFGPSTAAGAIKQLVFDFPEAGIAVELAHDGVFYLDEVRAAASASTGKSRASGMLSGNRRAETAVWRRPVLILIGIRLGLETVNPIYYESVKATFSFPQSVGIAGGRPSSSYYFMGHQGNSLFYLDPHNVRPAVPLRYPPTTFPAAAPSRFDVSHRYALEDRDDEDEWWSHAYTEAQTSTFHCEKVRRMPIKSLDPSMLLGFLVKDEEALVDLCARIKALPKTIFSFAESAPKWVDDDDFDPSMESFSEPSADEAGSDDDVGKGEDQDDVPPQRETRADKAEGTSQRSSPKTSVVFPSKRDTSPGESLYRESQQRTAAWLGHGRPAATVAKADRADGAGAGGIAFPSLDLLTPHNDSLGVQRPNRSDMRQVSTSSAATTRPMARKATNAMGTDEIDGRDLTTSAAVGAAVAGTARTGKVSPSRSPARAGPDESFSTVHLSDSEVGSGWEEVSDGGTIAPSASATSGLHRTGSPAPLGAAPSAADPSNESTWEMSSMRDGLTPEEVVSPISVVSESELVGVSLDTPTDEAAKNPFSAAGAKQASPVAPIDEGARHAGLTTAHTPLALPRRRTQSKPSPIDKAPSSDTSAPPVPSVPAAFLHAQPEPSDAASQPTRAPDLDASDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJG8</accession>
    <name>W3VJG8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJG8"/>
    <dbReference type="HOGENOM" id="CLU_024205_0_0_1"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="542" mass="58232" checksum="3D27926AD47DF2E5" modified="2014-03-19" version="1">MSSLRASSAARSIIRLVRLPVQPRSLQVLPRFAQQHPQVRALSSTSRRLSSPPSSPSKSPSGVGNVETPGFRPRPSVNGPGAVRIGTLFASLITLAVVVTGYGLYEYYTSFSAWPVSIRDDLRAALKARNRGDARRSENFFRKALATARSIKGELNEPTPTPKGQPAGLKGEGMLKISGIAIALAALLEGEGRVVDAYDVLQDVWDEVMETGMYARVAEEKGEVARTDRDKMRAVQIAQKLGMLGQLPEVRIELLNRAKQAPIQDAAEAKDDAKLFRFSLTGTAASEDPAERWLVWSVEELFRLILPADVHASALAAAAAPPAASKDKSAPAPKATLTEVEPPTSISLADLDLPAWVTKLDVLSSVEALGTFYAAKSVPEFAVPLYLQALSILLPPSTPSANRSAPTASERCKAGLIMNNLSQLLSRSNIKDASKWALKGLEITDTTVQKAGFESQPSAGVEVVQSSQERTNEVRLECLGVKLTLLYNLGVLSDMAGDKCSARVYFQKTYALASKLEGPAFTVAKNKAAESLARLERQSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJS2</accession>
    <name>W3VJS2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJS2"/>
    <dbReference type="HOGENOM" id="CLU_1001745_0_0_1"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000005">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="209"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="298" mass="33711" checksum="DD4BDBA54A3CAD47" modified="2014-03-19" version="1">MPSATSTPSSTIATLTNDAKMAAAPRPSVLATPRRPFGSVAPSNAEMRKVYADLDNNAVFDFASIVSAVKTFSTRFRAYTENAISNINDDKAEFDANRMEHRNQLRTLEREIEDAKTSQGELWDTIARERDQDADLRSRQQTLQSQKASVAQRCNELHAEIAELKQILEKKKLAKESQREKLKEQSDKNAPELRLLESKTGCSVVPTKVGDQLKFTFNLMNADDWSHECHFTIDVSSTKYKLTSVQPRLDSTLQESLLHELNSTRKFYTFVKKMRAALRAQVEKQRLEARDKARGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJW5</accession>
    <name>W3VJW5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJW5"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_0_1"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="447" mass="49092" checksum="5E59B22A89A89632" modified="2014-03-19" version="1">MTTDSQVKRLRVLVVGAGIAGLAVGRALREHHEVHIFEQSSFKTEVGAAIHTGPNASKILLKWGMDLDRIESPNCRHVYEHNVAGKLVLHKEVKVLEHFGSPWLLNHRVSLHRELLHLATSDDASLPGKPAVMHLSSKVVAVDGEAGRITLADGTTFEGDLIVGGDGIKSTLQQYVLGRPARAKPSGHSAYRLLIPFDRLKALQDETIDRIMSAPCLAMFVAEDRRLVCYTCKYNGEDLLNIIAIVPDEGLFEESTESWSAAGSLKDLNASFAEFCPTAKMILSQATECALYQLRDQDPLELWHRHRALIIGDAAHPMLPHLGQGGSQSIEDAEALAYVLRTSSGLPELGHVEEALKRFQKLRHFRASISQERSRLQALGPRPGSKEELLGKNPTEFAFFLYDYQGAEEWEQRMKEGRVGKPPGGPPADVPKPASVTEAPVPARVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK28</accession>
    <name>W3VK28_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_03572</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK28"/>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS62018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="590" mass="63458" checksum="DA350A702039FDB4" modified="2014-03-19" version="1">MQTNAENPRKRFTAGKESEAGPSRPRMANAVPAEILEDASLNQAIASILPANYNFEIHKTIHHIRKAAATCVALQMPEGLTLWATGISDIVERFTDATTVIMGDVTYGACCVDDYTAMALGCDMLVHYGHSCLVPVDQTAIKTLYVFVEISIDPAHLAATIRANFPSDKHEFRAKILGGSQNAAGKSGQVDESAGRARIAIGSDDAGSSGVKSGAGVAEEVPTHLALVGTVQFINAIHGLREALEEQQHRMADGEVVTGQPRVDRLMLAGGSVADGAVDHIEQGAKWKAWYSGEYRVTVPQVKPLSPGEVLGCTSPKLDKERIDAIVYIGDGRFHLESIMIANPRIPAFRYDPYTKRFVRELYDHAEMRQMRGEAVRLAQQSVGALDLDPETTVAAQQKDGEAGAEAGRVVASGWGVVLGTLGRQGSTRVLESLRTSLAEHSPPIPDVPILLSELSPQKLGLFGEHLAAFIQSSCPRLSIDWGSAFAKPLLSPYEAAVSVKKIQGWQEDVEGLGMSRTPAKRHGDKQEVPAEDKHLPLDGDYPMDFYSDTSLGPWTPRHGMAPAKKPAGAKSNLALLRSLRSNRAKAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKH1</accession>
    <name>W3VKH1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKH1"/>
    <dbReference type="HOGENOM" id="CLU_084854_0_0_1"/>
    <dbReference type="OrthoDB" id="2442602at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="297" mass="32531" checksum="BFC69ADB661C8134" modified="2014-03-19" version="1">MAETAGASASTPSARKPRGANPSTDYKSLFLKSKDKYDRVSTDHTDLVANVGKAALKQQKLREELDFLLDAIASKQAQRVRIEQAHRDRALELEREAAAAVAAAAAARQHASSLGSRDAKRDRGAYDSRFHAAAAADDYRPYSARYADQVSYAAYESTDRTRYASPPPHPPHAVAGSASSQRGDAYPASETTSPPRALPRDPYAPASYRRPTSQSPPVAHRARAYDQQSPPFRHEAHHAYRESTPPLPPPAAVASSAGAAVKRPRPISVERELLETEQGYDQDPRHRTHHTKRARND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKL2</accession>
    <name>W3VKL2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKL2"/>
    <dbReference type="HOGENOM" id="CLU_008894_0_0_1"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN / WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232:SF1">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN _ WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1124" mass="121837" checksum="93C0752877356E2F" modified="2014-03-19" version="1">MDWLDAFDPASASSRARSASTQQPPGPSRAGQSSTHAPASSQQPVSAIPRPRRPTHASRPPQRFSTRTPAAPPSAALRSEDAQPNEYQIRLKPWEMAAPPSIGASRSKSSQPAGGSVTRSQSRPAMGRPPIGRPPTAQPTVSYSGQAQSKKRPAPHQQHNRPPRSQRKATHQQSAMQHHQQPPTPQQPASGQSSSSKPKPKSKHEAIVSTHLKSVGQAPSQSQNATPKSITVHDINPEIPLWTEDAKYQAEKSVAIANLRRNPPDEIRRIREELAPLAEEQRGRARRGVADRFANPLLQSAATCLALCNYAQLALRLLHIRVELYRCAALLVPSNTAPRKHAFALVKHVRNALTQILGLAATDIDLSTFCSKEQILRPEDPIIVDTLDRIRDTDDVGLYAIAVLTNLFHIFGGRIVHIDWEDVDRWKQQHKIKSQGAPRPDVTTSVENKAVPAPVHHASVRQDTAASDEVRTPSAPPSKPVPPMQAAAHDASVARDTAASDEIQKPSAPPTPPIQPTQKKLEAASVAVTVSVADPEPPKDHPAEPAQPTCAEADNDVQAPRSPRDDIRTPTPPPSMLAQHGPCGNKHTPKVQRDPRSRSRSASPRKFGQLKGVLSAIDLSPRPSSPKPPTLKTEQTQDDMLEEARQAQELAILLEARQPDADDNDDESDDDSDDDQPLAMTLHAPVHAPAATQAGGTDSDPDEDVPLQDLLRRQSPSAATALAASSSTSAADYSASHAFQSAVWGLDQARAFSSTRGLSIKHFVPLASAALGAQTGVRNRASAFDSGLGVTDHGRIATFSEAPSYGDDAPSRVMELQTRDAEAKLKADKAWPIDRVEDVWRLTSKVCGIASSTRKLLGMGRYDEYPCQVSLVTMDETGRAHRTYHLDERPHAHGAAAMSHFPRTDPNDASSIDFATGGIDGIVNHWHWRARSTSADTQRLHTLHDAKPVVALEHLSSRAQTLASASMGTVIGFDLGALTLGFSWNTSDCIVHLQRTPDAKLMLGVLARRDYDQFRMFDITGANGPISRPVISFGWLNDAEGKLPLGRGAFHPSRRAIFAHGAEDGHVRVWDLRNARDPLVDLRVSDEPIVQAFWANSGQQDADVLYAATPRGVRTIAWRNAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKX3</accession>
    <name>W3VKX3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03771</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKX3"/>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="153"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="995" mass="108952" checksum="D66C1EEE4ADD410A" modified="2014-03-19" version="1">MDDYDEFGNYIGPLSDSDLGSDDGQDHQDDVAPPPLEPSAPLEGYDDAHDDDERLANIEVDEDGNIIPQRQLIRVDEGPSNAVVLHEDKQYYPSAADVYGDDVETMVQEEDAQPLSVPIVEPVVERRFAVQEDGLPETRFDRSFLANLMGFPDMVRNVAVVGHLHHGKTSLLDMLVYETHKIQHDMDNHLRYTDAHTLERDRAISIKSAPLSLVLENTRRKSYLVNLIDTPGHTNFQDEVAAACRLADGVVLVVDVVESVMCNTAHVVRHCLRHKLPIVLVLNKIDRLVLELRLPPTEAYYKIRHAIQEVNNLIASIDANPALQLAPERGNVAFASTQMGYCFTLRSFAKLYAETYGAGVDVDAFAHRLWGNIYYNPESRNFSRTPADANTPRSFVHFILEPLYKIYTAVLSSDTPSLRRTLATLGIRLKPAVFKIDVRPLLKIVLGEFFGPAQGLVDLVVDHVPSPRAAAAARLADAYTGPKQGAAYKAMAACDADGPLVVQVCKLYATVDALDFRALGRVMSGTARAGMRVNVLGEGFSPDDDEDMVAATIDSVAISETRYSVGVDGVAAGSWVLLSGIDASLTKTGTLVDAAVDTEGMGIFAPLEHMTQSVLKVAVEPLVPSELPKMLDALRRVNKSYPLAETRVEESGEHVVLGTGELYLDCVLHDLRVLFAGIEIRVSDPVVRFCETVVETSAVKCYAATPNKRNRLTIIAEPLEKGLAEEIESGAIDVHAPPKVLAKLLQAKYGWDVLASRSVWAWGPGERGANVLVDDTLPSEVDKTLLYAVKESIVQGFQWACREGPLCDEPVRNVKFRILDASLSPEPMHRGGGQMIPTARRACYAALLMATPRLMEPIYEVQVSTPQDGIAAVYTILAKRRGHVVQDTPKPGSTLYTVKAYVPVVDANGFETDLRIATQGKAFCMLMFSHWSIVPGSPTDASIKLRPLEPAPALALAKDFVLKTRRRKGLPDTIALASYLDADMTMALVQAGIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLG8</accession>
    <name>W3VLG8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLG8"/>
    <dbReference type="HOGENOM" id="CLU_073626_0_2_1"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="159" mass="18203" checksum="80B885B82D579764" modified="2014-03-19" version="1">MSNVELGVQTEKAFQKQPIFQNSKAARKTTRDRRWYKDVGLGFKTPRAAIDGTYIDKKCPWTGLVSIRGRILTGKVVSTKMTRTIIIRREYLHFVPKYSRYEKRHKNVAAHVSPAFRVQVGDTVTVGQCRPLSKTVRFNVLKVSKNKSAEKAAKQFGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLI4</accession>
    <name>W3VLI4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLI4"/>
    <dbReference type="HOGENOM" id="CLU_597331_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="458" mass="49895" checksum="893C81D1D640B1E3" modified="2014-03-19" version="1">MPTAPCTRRGVCDSNWLLSVDGPLPPPQLSPRGGSFPTPFQRRACRRAAAVAALNNGLLRLGAKMQVRPVEPKQSLGIAALVRARIDAPLLQAVVDPWMPSCRTLDQCTARPARSSSSSRPFQLALEPVRSLCFSPRELGKFETGAAHGCPLRCWPPDSPHDNAARTTLPPSRFGTHLERPTRRRIQVFSPNEAQVFFSLPPPLFAAQAQPKRSSSPLSPRWALPPSPPSPAAHPLGFEAWVPSRRAPAAARLPPETLRGQALLLRLAAALLFALPDQAWLLTHPLAQDARNAHDAHNAHGSPLDLRTWADTSFPQPPPPPPTAELQYIPSTLNPPPHLCRGAITIWTSISRNTYLANLHFWFAQSIVCHPRIPSPKLPSPRLKAFSIPKPSLQPPPTQTQAFASHPYTVLSSTPTLHLALRTTQLSHPRDSLAILSYAHCSSTLPLHSLIVSPKVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLQ6</accession>
    <name>W3VLQ6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLQ6"/>
    <dbReference type="HOGENOM" id="CLU_1204627_0_0_1"/>
    <dbReference type="OrthoDB" id="2541451at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834335" evidence="1">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="230" mass="24869" checksum="A518990FA3801D5F" modified="2014-03-19" version="1">MRFGTSSTLCALVAVGGAYASVLPRVLDSYDLGMPVLEREVPVLQCDSQPLHVGQLKLVSSAGREVSAAFEGLRDADGFQQLDVQKAGQPARYENFAFTQCNSTFMAYQPEANKAAEVFYGRLQPAHLVGKRCVAADYLAKADSRLIADKCNPSDDSGQLLQFWSLTKQPALEEGKFQYYVNFLGQPDGQSADFPGGYTLSKANVGANKLVCLAHNQDAGKPSAFFLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM95</accession>
    <name>W3VM95_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM95"/>
    <dbReference type="HOGENOM" id="CLU_1960508_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="128" mass="13846" checksum="0A5FAD4D6D25838C" modified="2014-03-19" version="1">MLACLFGRPPLPPILAPSPPPPPPTTQRQLPLLASDAAAAWLSSALSLVQSHLRPDLPLQPSHPTSDNATVPPRTSATSHRVAPNQAWQEPLQQPHLATSRSHLKDRCYPSQHHPSTTQLIYTMLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM96</accession>
    <name>W3VM96_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM96"/>
    <dbReference type="HOGENOM" id="CLU_273115_0_0_1"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
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        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1167" mass="121024" checksum="46869C30E8EB7094" modified="2014-03-19" version="1">MPASLENGAAVLRDVPSFVSARAANTIISEDRPTRIQAETLLVLNGLLDELLLLILASAKSLATDRIKSDGMLKVLSNNLLAKDAVLEAELELRSYVDGKRAEGAKVPLGLMATSRLDGTDGFPVQSAFKALRLRCQFYSTLGDCDDDGLAKDQNIMSTDGRPIATVTQGVAIYVTALLEYIGQHVLQNVSRVIERDNSDEASLYDLRAAIIEDEQLNPLYNKMAIKQELARRIDILEARRRKRTEDGARSGVRSDARVVKPWHVPTEGDFDEAAGPTLFSAKRASVQQPLSTASSSRHGHAASSSLGHADSSSLRASTSTLRTSSSIANHNAPESSSLVSSTGGASAQSNSRSSPARNASGTTSRSEASTGSIGRRQSSDRSWSGMFGSMKRRGSFKQGSDPNGTAGRPFLQPDAASLQASQSGSALDPDDDFEALMLSNQTMKVSLTPNRLHTIEVAMKGDDANLGSVRRRPGTAGLRDEAAPAAGTFGQAPSPSATLSSQMSDAQSGAVNGAAGVLPETTFPRPSSRASLQTAVRPERRAAPPPSSYRSPSPAFLGKTNLLSRDVLEEDAGLPAQISAAAPRRSGLRLQPRDDEAERASSNAKDLVDLFRSTPPSATSERFGSFGSDTASLNDGSSKKSAMGDRVRTLFGRKSTSSSGHGTPASPQQKTQRSMARGDTKPSLEGSQDTYVTSSTNNSMEQSRSLFSPTEAPFNRSAASRSSTSTSEHPTASADAAPDSKTTPDVTVVEPDTDALNGTNGLGIGTTAAAAAAAAAAGTAGIMAATRSVSHGSRSTSHASQTPSIAEGTIHDDTIADDASATSKSKVTEELVSRKVPWGYKRNSTNAGQLIERSGTPLSDRRRSIGYQSSNGHGVLPVRGASSAALSDNGHGAGGATVPTTPIASAADERGAAASASSAVRSANAPSAWSGSIAPASSLTRTRRSSFGARPSTANQARRPSAHLETIQLLAELERAMRNCHSVDECRALVQKAMHSDGTPLSPSASGMSAASGGQEADGDRKGQASDSAAGAVAPSADQSNVAPAVTSGEKTSSKEVGGAALGQTGSGCAITSLEQAEQGLVVAWLLGGDDDPEPRRDSKAAERVVRESVTSSGSGLTNGEADETVVRNFSLDSTASGKDVAKLASSSVVSLQSNYKDAQDEVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMN7</accession>
    <name>W3VMN7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMN7"/>
    <dbReference type="HOGENOM" id="CLU_328506_0_0_1"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="860" mass="91003" checksum="8090EEEED8AFBC2F" modified="2014-03-19" version="1">MMHDLPTPAPSSDPPMPGSSPVKGGKSGKALVAAKDAAATRPFAPLDLNLVGARVKTFQETREKAGATPPPSSPPASSVFLSSPVTQPRQQELGFSPVKQQRAFTPRTQPSRDSTVGAPGDRAQELGNQLLGLVPNTELDADTDAVPNLLFGSKSVSLVIGRSKPSGEPHAMAAHDASQQSAAGDIPPSMQGLGAKKVLRVNLPNDARHVSRIHAIVEWIPFVARAAASKKKTVSSFTAKGSPVGARLASQSNASGANGTFIVRIVGQNGLIVEGKRRREGQVLRLTPGKTLIDFFGVKCRFEHVPSSTDRRASPVKSSQAREQEWTQRVTSPVKKGAADVQAPVTTQALESMPASSPPASSPPHMLGLLSPSKRANNNRGRASDADAEDEEADEVHSSPTPAHRRGGGLVAGPLNAQQVRAGDSDEEMASGAKALLDDDDDDDEDDESDDEDYVPAEFEPKLKSVSSPRKPVAAIAALDDDSSSLSDSDAVDEQIGDAALATQPTLATATRKGTPTSEGTTSKPALAGDLTESQAKMPPPTATVAAVRNSARRSASNSPAPSSPLLGSSVQELQKLARNGVSQLAPTYDLPGLLAGAIVFHRTATISASEAVRSVLTTTPGLMKGQAGEHSVAFSPSKRKLPGAATLQQGCTVDGWPTQSEGGERWTSIARKAWREHLEVVLQSSPMFGVIQRAGKDASGNPLECWYYYDKENDPDKERAENLGVFAKPMRKALKGQKPIFWKRSGYASRQDEVAEVKPEANSSSSSLVGEQESIDIASAPLPSSSMANGRKRKAGAMSQTQAETQTAGAGAADDEARRREKLRVKIARSGLWDETQPEEKEAPTWDRKGDQDYRKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMW1</accession>
    <name>W3VMW1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMW1"/>
    <dbReference type="HOGENOM" id="CLU_008680_0_0_1"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="805"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1130" mass="120680" checksum="0DAD856CD53A7323" modified="2014-03-19" version="1">MPGPYHRRIDTLALQPTLRPSSASLGSASTATSLKHSLARHAECELRAMTMALPSFLGATATSQPLPMQLDLDDPERAISQLKAIRNAVIGSRTKKSSLVHTRVIQQLVELLHVDLGATPHAFDLVSLAATIVASLANTPAHSTMLQLMRSGTHDALLACLTNLTHDLNRSGRHILDPVHGSFDTLRLLESVLRALRSILLSVADQLSPSPRWGIGSSWGTKPAPAGVAISNPGAVAATSKIFGKSSRDSLPASPVPIQDVLMNSASNDNLRDKLRHDQVESEAQQQRELRRLARIFLARVYDPANLALLLGPLFMCQLPQEQTSAMRPSSTATSHSASPMRLGASSSATAVDDVRHEGAQAQTSGEEGPQVVIDVERLPMTVKTKILGVVEMICAILSGTLFIPGYAPDAPAVNSTSVADQISQRRERILDFSAVESPFAPDFKLGPGARGRSEAVPASRSSSQLQAEVIRKGSRSRSRMKDVEHAGTFDTPPLPPWTEDEVEQLRAPSDLASTGPPTLLTVLLAAAESGFVKAQEAALHCLVELTRDEPEASARLFKCLSPLGLLPTSVLLNFRHTSSANVRLAAFCCLANIIKVHPFSAKTNQCVLEVLMELLDRSPSVAPAATTGASPSQYQGSSHVEIQIQAAFAIARLVADNVTLQNLATESYDALSKLALLLDHACTRSQPSGPAAKVDRSNTAAAAILGSIAGTKTRADSTIGVAPPTVDESAIRLREACLTALAALTFQHDEPRRKLIDSVQPPVLAMVVSSISFPALGVRVSACRLTRALSRSLSILRTSIVDAGVAPKLVALLQDAHEEEVVRVEATAAICNLVLDFSPMKKLIQELGGVDSLVELAHGGARPRADEGEDRYYALSAAATMHTSSVPGAGKEHAVRAVRAGLSGSQQLRLHALWALKNLLSHSDTALKVDVMEKLDFKFVAALCEDAEVEMVFKEQALNILRNAAASKESDVTFMVDGMGGGARLMATLEKCIWEGRSAGEPGAAVIEQAAFVLVNVATGTEQHRKLLLRRPNIMDALAFFCNHPWKDIRVAAARCIGNLLSRPKSSAEPPTQLEADAAYPDLHSEAKARLTTFGLDVKIAELAQSDAELDVRERAKSALNKLNADAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN24</accession>
    <name>W3VN24_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02828</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN24"/>
    <dbReference type="HOGENOM" id="CLU_023534_0_0_1"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="445"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="403"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="626"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="731" mass="80169" checksum="1ADAA15A4DDE6CBE" modified="2014-03-19" version="1">MTTAQARSDTDDRTNSVLSTSSHTHVDYPDGSQQSPRSKMTAWPTKHPEEYELNAGQPAQAEDVAQRALAIDTQGQRGPTASTERTQAGPAHPPPPVCMQNCISSIEACTQDIARFNERVEQNRVEAEAQRRESGDPVVARKAIIPLVFVILFWVFFVFVWRLCSRMIQQTPQGVVLGTRSEGIGILVGFVVLWLMTMWSYVTVISKGPGHVKDYVPETAPPLPGPHDATPWNQGAAPQCGPQQQHPTQPLPIPTQHAGRHSNIPASESSFAHSHGLPSSNSLPYPSFNADLERFGGNRASSDSMRVLPGSVEPKHDMTAADLSHSRNFSQRTIAEEEEGAADTSAVDVEAQLRSEPAPATEGCDVASHVDPQLPGILGPLAAATIAEGDAMREATDELDRARGNVDRGPHTEPAEASAALPGSSGWSAPQRRPPNDPPPLSAAAQYCHRCKRVKPPRAHHCRRCGTCVLKMDHHCPWVGGCVGAHNQRFFFIFVLWVTLLEVYTLATTAVYFHRGVRALSSNSSWQVDGFLVSLFPICAVFLIFTGALLGTHVFLMAHNMTTIEHVGVNRMQGRERVLVDRWFGMQANSSAKTPGFGAGLKAKRQMIRDWDREWGKLTKEGNRWWLGSSSEAEAQETSAAQDTQTGAQHEDGGSIHAAHEKHVAEGKRAGHQRVHGAFRTNTAQALGSSMWMWFLPIGKHPNDGLDFPMNPRFGPQGVWRKRPEWPEHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN30</accession>
    <name>W3VN30_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02669</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN30"/>
    <dbReference type="HOGENOM" id="CLU_000995_6_0_1"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000018">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="301"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="678"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS62905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="906" mass="100219" checksum="439598EF696AA6D0" modified="2014-03-19" version="1">MSQALNDGSNLDLPVFQDDLLRDRQRVFSEFLSKDEYQDAVRRMLRMDARRLIINIDDLRSYNREFATGLLNEPNEFLPAFDAALHVSVELAHNTIKDDIKNKQYYIGLRGSFGDHHVNPRTLRSMMSLEGIVTRCSLVRPKILKSVHYCENTAKFHQREYRDATMYGTLPPSSTVYPTEDESGNRLTTEYGHSQFRDHQMISIQEMPERAPPGQLPRSIDVVMDDDMVDRCKPGDRIQLVGMYRSLGNRVGQSSSSTFRTLMIGNNINLLSSKAGGGIAQAHITDTDIRNINKIAKRKNVFNLLSQSLAPSIYGHEYIKKAVLLLLLGGEEKNLPNGTHIRGDINILMVGDPSTAKSQMLRFVLNTAPLAIATTGRGSSGVGLTAAVTTDKETGERRLEAGAMVLADRGVICIDEFDKMSDVDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVVAAANPIYGQYDVHKDPHKNIALPDSLLSRFDLLFVVTDDVDEQRDRMISEHVLRMHRYLQPGLEEGTPAVDNLDQALDVGAPEGTDADGAAMLGDTSPFEKYNPLLHSGVTGSGRGNDKKEVLSIAFIKKYVQYAKSRIHPVLTKGAAEWIVNVYSNLRNDELSGNQKRTSPLTARTLETLIRLATAHAKSRLSSKVEERDAEAAEEILRFALFKEVLGGRRAANKRRRTGNSPMSDDEDQDDDDDDDDSADEAARTDPNAAYRGGSRVRGGRSRDGGRRGGDRYGEDAHSSDDDDDDAGAFVSSQRSTRSNGTYATRAASAGRAKPKAAMVGPGGMDEEMLDEEDMDALEAMRSLDVEVVIPSQAPPPSAPRAVSAQRIEAFKESLSDLLFASDGRLAETDAIPLDELLPVMNEGRRTEDLFDSNEARQVLEQMHRENSIMFSEDMVFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN66</accession>
    <name>W3VN66_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN66"/>
    <dbReference type="HOGENOM" id="CLU_366091_0_0_1"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="755"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="780"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="654"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="816" mass="84653" checksum="0383107D286F85E1" modified="2014-03-19" version="1">MPTCVFPSRHRTDESAGAARRLVSKELPPVLSSPQCDHPADRGSGRQQHRGTTIAARLAPGSIPRSALAIGVPLAHIGSHKADAVSLSISFSLECAATSEGSCSRDGHGAKPIAPSDPTISYSCFFTPNHVAGPPCSSKRSSRLDSRSSSSSQNEERTDSLTSSLQPLPLPTNPTLSSNLPFGSISTLSSWTNSQNVNLTAPNKLSSTSPSWLSPLPSASPASAKSNNPQVLSKPPQSRSPTAQPPFLKGVHRPTNDNASAPSPSFLNSSSHHRRSSTPVAAATAAPISLRAHLEAAISNPSSPYAQANLLRQLQSTLAAVRPSPPHVHAAAAAAAVAPANSPAPATPAQPTFARVPSITPAAVASALAAAAAGRRHTLSSSASPAAATINSLTPAQKQRLEQIRHYQQLIAQLNATMPAAATTAADTSVAALLPFEARAADHTKVESGFNAASLGLNPMSADDPSWIGHGFQAHAAEDFLSSPDWTDPSPALTDSMSFEIDSCGPSPLLPLDSYDDDLGVPGIAGAPLFPPQDGYASSNVSPLELASHDFGVHTAGDFGAPEMSSDFSLFPDAKPIKLPVEMAFSKLGKPAAGSASSTEDPALTLLRALSSAALSSSATTAAASVATSTPSAPALTASPLAFTSMAAPLAPAPAPVSAAPALAPAPAPSAQSGPAPAAPRSESSSPDAMDRRTSTSSNKTEARGTKRRLDTTDLLPLDAPIQKRNYYTVSATSRRDTAEADEFAEEEAAIRREKDPRVAKRLSNTLAARRSRHRKAEELRLLHEKIEALSGEVESWKRRCELAERERDEARGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNA3</accession>
    <name>W3VNA3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNA3"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="315" mass="33360" checksum="E61F72631B845CAA" modified="2014-03-19" version="1">MLTLRPALSNASVAATALRRSAFCQRSVLRSYSTATDPSQLATLSPLSAIAQSELGSSSPYDEHISVLTLNRAPAKNAISRALLAEMDQHISSLLTNPTSRALLIRSSVPGTFCAGADLKERKGMSKPEVDAFLLGLRKVFTNVSRLPMPTIACLDGLAMGGGLELALTCDLRIAGPAATKLGLTETKLGIIPGAGGTSRMTRLVGPARAKELIFSAKLVDAVEASRIGFVDIVAQEGNGTAAFSKGVQLARSFAKNGPLAVRAAKLAIDKGEQMDPETALDFERQCYETILGTKDRLEGLKAFAEKREPVYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNA9</accession>
    <name>W3VNA9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260260_0_0_1"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="793"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1336" mass="145621" checksum="87B9BEE68062FB09" modified="2014-03-19" version="1">MLSQAASRPRPPGLRRVSSQRPSQHDQAQQPDAAAPQCVADDASSTPHRSPFSDVLNRIHDPTVNISDKSLSSDPSTRSQTKPYMPTGQPSCDDLIDENGGTLLHTIPSSLSQQDLDPSWLGALERHELEELLIEASRKVREREQKLVVAANIGKALLEKNLSLRSGIMSSMASSSSLFGLADIEAMIEDFADPSDATSSVNLEDQGLDDEPAQYPSSRPMYSPPTTDIDIQSQGPFSPAPSEPDNTPLAHPVVPGTTGSDYFTRPTSDGSDQSSKRSALDAPYNPAVVSTWVPNESGLVPSQPCSPSASIRSFASQAFLSPVDSVSRAPFKNGRANTRHRSRPSLVQIQALEAQRQLASLGEQNDVLHQQIAELQHEAESARFDGSKRLNRLNKEIRGLKAELEAATKRNIELETTTSSTRPLASSRTPLRSPANRGSLSQEPKSPIFLLDRRHGPSSAATLLPDSMPAAKDEAVSNQHGLAPSTSTLEDLVRSTQSTTGESALVVQLLAKIKELEETNATMAKAELDFGNRVGRAMEEDERLRDAFNTVGQDFGRDATFGALGPASGNVDSHTHHSPSKVAALQPGFMTPSGSQRSLASLASSDMSSPVASLSPSQKRRAPGNRHIIEHRKTVRAAIRRAKKELAADIWNSNGEQPLASGTTLSRSSTEQSLGTYSIDLSGESSAASSPRSRGLHRKSSASSFGLGPAGRPRIRITPSIEDLGRRRKTQERIITGPAHDSSPAEDWQDVITPTLASFPRQDTLRPADAVQSHANRSADETLEERGRDRSPARTSRQASAASSPTAGMMAYLSPSRQWSSDPTARVRRSRTRSSSFVSDGRSAYSPSLRLHSPDSYLGGRQRTTQSPASASSQRGRTLGSELGSIFGGDDRRDDFDDDLPQNRRAIVSATQNAGAVAPQALVLATNNAMSLQLWTPLRRRAESDRPTANVGRLVPENMGEHTDDLECVLAHPAHAQIDDVFLDGSPLRPRDAALLTRVEDAERGEWLADEPIIEAGGLQDEDEPRGAQFDLISAVVENEAVAWADDDDYGRTISQRDAVKLGLLAPSPSHADGRGLRAIADRSKRGTSIFSSTKASHKGKAKQSGGTREAAPFRLEIESSEQVEDRLRLESFLRRRRLDLLRERGFSDGRTPDEYDQKQEDQLVAMYAPTPRRMHEKRRRALEGDHSRSKLALSPQSRESSHSMRQWLRDVSSVSPSVRDDEDRRDAGNLDLDCIGPEDGEFELLDCPSWKKQGGRGTDYFPTSFRARYRPAMVKQRAAHVSQVTYAWVEEWVQFAFVVFLAFLVMVEQGPNRAMHRAKAQAKGGAVQALMPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNM8</accession>
    <name>W3VNM8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNM8"/>
    <dbReference type="HOGENOM" id="CLU_049481_0_0_1"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="168"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="250"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="448" mass="47499" checksum="D36E93975A33B4BD" modified="2014-03-19" version="1">MPCCRSPRSSPRVLITTIALSIQPSLEPRAASTALHQPKLEWQHADARSHRSPLFPRAPGASNLARVARRRAMSAKKRSRASSIASSEMHSNHHSPSSSHMGASGGVGASSSRGASALPASGPLVHASQDLDDFQASFWRYQMDLVEQGGDADGNVVDFKSGLPTQGQLPLARIKKVMKADDQVKMISAEAPILFARACEIFISDLTCRAFLIAEEHKRRTIQRSDIAGAIGRSDLFDFLIDIVPRHESVPSSRLPGGGAAKREKTGEGKGVGRASASRRPQQHQPPSQLQHSQDAGSYDDSVLHAVSGAYADAEGAASDSLNIPHTGGASAPLDAAASSSGMAHWIHDTSSADEHSSQPDVGSHAHHSHHSHHHASAQSHSQHGTHSPHDLHHHPHPHHPALSHAGHHSHHHHSPLDYVASNAGTPNSIGAGSANGSAWSHTFSGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNU2</accession>
    <name>W3VNU2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNU2"/>
    <dbReference type="HOGENOM" id="CLU_013985_7_2_1"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000098">
        <property type="entry name" value="N-terminal acetyltransferase A complex catalytic subunit Ard1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="152" mass="17485" checksum="7FCDBA31F038704A" modified="2014-03-19" version="1">MNIREATIDDLLGMQNCNLHNLPENYTLRYYLYHALTWPQLSYVAEDEKHRVVGYILGKMEEEPADGIPHGHVTSISVLRSYRRLGLANKLMKQSQEAMRDVFGAKFVSLHVRQTNRAAIGLYRDTLGFEVHGVEKGYYADGEDALHMRLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNW1</accession>
    <name>W3VNW1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNW1"/>
    <dbReference type="HOGENOM" id="CLU_001265_52_2_1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="598" mass="64766" checksum="3C35433DFAFD505E" modified="2014-03-19" version="1">MSSFLWRRKAQSAAGDHGATTRASQDTDDATLTEFSRMAQEMGVGGAYERKVALLNRTIKDDIGFGKFQIWLTWLAGFGWFVDNIWFQALSMSLPQIKLEFGPAHVQFATLALYLGLLIGATFWGFMADVIGRRPSWNITLFISAVFGIAVGGAPNFVGLGALLSCLGLGLGGNLPVDGAMLIEFIPSTHQWILTFLSIFWCFGQLFAAFIGWAFITNYRCETADACPRASNMGWRYTWFLLGAVTFIMWVARFWVYPIPESPKFLIGKGRDEEALEVIRFIAAQNGKTTSLTLEQLRAAGEGTTIAVSADAAEQKFAADEDVEAKADSAAEAQDEKKANEAGTHVRAAPTPGVQVETTDDVAATTTAVPHSLKGRFLSAADLAQLRRSLSEFDSHHLVALFSTPRMAWNTTLICFLWGLIGLAYPLYNAFIALYLQNAGANQGETTQAEQYRDLVIIAACGIPGSFAAAAMVELPYAGRRGTMALFTVLTGLFLFLFTTARTPAAVLGWNCATSLTQNAMYAVLYAISYEVFPAPNRGTGDGLAMATQRVFGVIAPVVGAYAGSTPTTPIYVSASFFMAAAVLMLMLPYETRGRSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNX5</accession>
    <name>W3VNX5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNX5"/>
    <dbReference type="HOGENOM" id="CLU_339221_0_0_1"/>
    <dbReference type="OrthoDB" id="2550042at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="838" mass="92085" checksum="F7C2DEAE962DB20B" modified="2014-03-19" version="1">MKHGHRTGFREPTFQDALLGLDFIWPLAPPTERAQRNDHDASATTLQSNFLATAVAPTRMFCYLATPPLPFLRNIPSFPICFHHDGIVTMRILTSRLLVATIVLLLLAASCQASVSTSHQSHDFFEAAPSSHHLQKRVDEETVASAWSKAQVPERLRNWKIFQDGGGFRETIRKGYIGFLRKLDKLHEPYPEFRHIKKEWIYEKDLRQHYVLPRVLRIPAITQETAIPNLKPFVAALKDADSELKLNTEARERVPTLSEHLDEKEAEATAADSDAPPSNRNNAGTDTSQDISGSPQRGSRRRRPRRFNRKNSFQQFRPAEPVPEQPPLSQASSLQRSEILSESSSARASLDHPERAATPVQDETNADQEADKHPSAMRGFRDSIMKFQDRFERIKKFRDDQIGKASLHYQAPTQAFAPHSVLSPEEIGLSPVRLPTIRSGDSSLEPTPRVDDGKGNEADVSNSVSPALRNSDPFGHSTGLHRSGSVESQWNGKTDPSPPLSPYHSSTPRYGGRTGTQTPGEPGLPYNYAEILHAARVRHGFVQRTQNPADASKQSLWRGSERAGSGSDTASESGLGEMSPSRSAIQRMQEEADKHNIGYVVYDGPTSPGVRTPRSPVSDAEAFPARPVPPELKPEVDAQTDPRLRNAASGRRARTKDITRPAPLGSLNVPPRFEASQKSLGSADPLPGLESSAAEQSPAAKRKRPSALGEPSSSPSPKSFVGFGPPPGELPSPQFAGFQRSISGKDQPKVADNPPNTSPSPIMDPSVPASVIFRRQRLQNLVRTDPNYLSKLRGSTVAASEANIRMARDPNAARSGRDSPDLGRAPTFSPRTMPIQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP03</accession>
    <name>W3VP03_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP03"/>
    <dbReference type="HOGENOM" id="CLU_012201_3_2_1"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="7">
        <location>
            <begin position="454"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="7">
        <location>
            <begin position="710"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="834" mass="87517" checksum="6D823678BF660FB6" modified="2014-03-19" version="1">MSQSGGSGSGSSQGGSRGGTARLTELPNFHPRDWCGSAILSPLLISEKYGSADHRTEEPAQKNYAEDKLPSSRSSTRSPERHFLFASVSYKELKVGEPILRQAAHALSRTPHPTLALSPAVRSALDPKTRAPVVALESTIITHGLPYPYNLEVAQELEQTVIDHGAVPATIALLDGKPLVGLDEPQLERLARCAIDPSKNTAIKASRRDIAHVLSKGHGSVGGTTVSGTMVLAHMAGVPIFATGGIGGVHRGAESTMDISADLTELGRTPVAVFCSGPKSILDIPRTLEVLETFGVSVTTFNPTGEFPAFYTSNSGLSVPYAGTDAQAAAAIFANAQLGLQSGHVFANPIPAEWNEVGQRIQQCVEQAVRESIQQGIDKKGKEVTPWLLKRLAQLIPESKKSNRALVVNNAKKAAQVAVELSRIENEVQQVASTYALGGIPQTQLSTGKAGILMFGAAAVDITSQTQSAGTASKLAATTYPGRVSITLGGVARNVAETATRILSPLHTRSTPSPVKLVSPHGDDDFGILLRTGLGHAGMRTDGLFVPSGNHRTAVCSLMIDDSGDLISGVADMDIGKAALTSTSVDVNSLLELEAPRFVVFDGNIGQAHADELLEACRAYNASGETVQGSRPAVLTVFEPTSVAKSATVLPHFAAAAADGNTKQPISFTTPNAVELDWIHAAALDYGLLDPTKIQPTRLASSVPSSVLPQTALHKAHDLVQAGIFGTILLKLGRHGVVTIDISRAQHHPVPAGKVEVVNTTGCGDSFAGAFAASLFHLLAQSQETRAVAGRSSPGDRLDLAVRVGQLAARRTLLSTKAVGEGMEDLLLKQNRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPA5</accession>
    <name>W3VPA5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPA5"/>
    <dbReference type="HOGENOM" id="CLU_006320_4_0_1"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="699"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="734"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="754" mass="82226" checksum="EB358E3CB144D1AD" modified="2014-03-19" version="1">MSRPRFFNAPRKGENFELRADLNSEYRDRRKDAIKRVIANMTVGKDVSGLFPDVLKNMQTEDLEQKKLVYLYLMNYAKTQPELVILAVNTFVKDSEDPNPLIRALAIRTMGCLRAEKIIDYLSDPLEKSLRDDNPYVRKTAAICVAKLYDLKPDLAVDRGFVGMLKDMVGDSNPMVVANAVTALTDIHQTALERDPTGQSAVFVIDSDVLTKLLIALNECTEWGRIAILNSLARYRARDEKQAEHICERVMPQFQHANGSVVLGAVKVVLIHMAKVRSNDELIKQLVRKMAPPLVTLISSAPEVQWVALRNINLVLQKRPDILQNELRVFFCKYNDPSYVKLEKVEIMIKLANERNVDMLLSELKEYASEVDVDFVRRAIRAIGQCAIKIDAAAERCVHVLLDLIATKVSYVVQEAVVVIKDIFRKYPHNYEGIIPTLCANLEELDEPEAKASLIWILGEYADKISNAEELLAHFLDSFTDEPYQVQFQTLTAIVKAFLKKPDSGVAQQIVQQVLEKATKECDSPDLRDRAFIYWRLLSSSDSAAGRNVVLAERPPISIPLTTVPPGVLDELVAELSSLASAYHKPAATFIGKVRFGADGVRSLGAEAGEDEITREKALATVVQGQKSENLLDFGDDDVDAAPAAGSASNGGGALGALAGLDGLMMGASISSPTAQAGGGAKAPPAAGGGLNDLLGLFDAAPGADEPGAQSGMQALNALSQPMAPTSPVPNTTASPRPAQPAQSAQQDDLLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPS2</accession>
    <name>W3VPS2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02486</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPS2"/>
    <dbReference type="HOGENOM" id="CLU_044249_0_0_1"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="3">
        <location>
            <begin position="159"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="490" mass="53903" checksum="3730741A4B512191" modified="2014-03-19" version="1">MAGPSSKRNSRGRPSEPEAPPARTRKVQFGGADEEADSSTSGSAPIELNPDVVKALISDARTILADLGPQLSARSPTKLATSAFDISPENLSLHTLRDQLLSKADRNHQRRLFGDNASPAKRRRSSMSQFASEGELDINWAVYKEWPEGLNEEERLLLDYFKKLKFIYLEQETKMRFMADIQDDLDSGKEATVYSAAEVAERERAAKALKTQLTDAKAEVRALRREVDAAADELFEPWQQVERDSREAEQLIKEIGDMELELAKIRAQNHGKGGNVAAIAGRDGPLTTSEAEEYCDAQIGDMTALEGKTTDVKRAIETTKKDLVSSLRALDRINAERSLAEKFANEAKMGMGLDGGRDLETERLCASHIATIGLLKSLLGVDEIEAISANEIRITYKLPLDSAALNAQMQNGEAKAAAPRRKRKSIALPDQSLVHVNLRFRDVGGRIDNVAVTSSKGEQYHMPEASLARLRALQKANDVPLIVQEVLAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPS4</accession>
    <name>W3VPS4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPS4"/>
    <dbReference type="HOGENOM" id="CLU_013985_41_2_1"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000086">
        <property type="entry name" value="Acetyltransferase, GNAT family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="176" mass="19532" checksum="8742BBC3D3282DAE" modified="2014-03-19" version="1">MAALATSADKQFTIRQGTKADCAIVLDFIQQLADYEKEPDAVKATVQTLEENVFNKGYAEVLIAEQHDSDSSSAPVAVGMALYFFSFSTWTSKPSLYLEDLYVIPTLRNKGVGKLLFKALGQVAQQRDCARLDWSVLTWNAPSIAFYTQVLGAKPMDEWKGMRLEQQGIENLAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPS9</accession>
    <name>W3VPS9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_01791</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPS9"/>
    <dbReference type="HOGENOM" id="CLU_408921_0_0_1"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040967">
        <property type="entry name" value="DUF5595"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18077">
        <property type="entry name" value="DUF5595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="155"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5595" evidence="14">
        <location>
            <begin position="295"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="392"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="545"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="687" mass="77033" checksum="120E1166EF6FA903" modified="2014-03-19" version="1">MTSTTTSTRRSTLAAIDPNQNNGHIASTLPVPSSAVKSAKTYQPRASMIPQQSNPVRNVSATAATAATATTTAGASTRESLLQSTQQPITSTAVHSASHSARRADSGMYAGRQSVASAGRQSVAVTTPATPNSRRSMVGRLSIAPGNIGNTGGSGVRETRPIKDKHYKTRMGLTVKEHLERTGFTMVGWDVNKGVHEPTQSAFVGMFKHIYATCIDTNFQMGADGKKFEDEVLMLMKEIKYPAADELSKTKLTAAGSQSHWPYCLAMLEWMVNLGNQAETIGTGPRSRPDEIDDLQSLFFPYLWDCYDRFWQNEDTYPEEHAKLGVRFEHKNAAIERELRELQQDHARLEAELADYLNNDSPLKVERSENDMLTKDISKFHKYYDEVLVPKLDKTKKAIERLIKEIALTEKEIDDKNKRRLDLQQQVNAQEMSAEEYERMLAERNRLSKRLEVLGEQNKKAAGDGWSLEIAIAKKQADTEDRISKFNPLARSIALLPFQLASGGVVEELELTPSNPSTMLQAGVDIKGSFRRQIEVLRSHEADRYRQASKRRLTMQEEYEKLQEAVAAQEAQLGSDRERCDALARQAAEYEKSCKTVQERYKADESKLERSTYETEASGSVHLQQAESRLTSLQLSAEHKEEEWSRQRSRMDEDMLSFVVLLSKMKGDVTGQLREIQAAVALKSRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ15</accession>
    <name>W3VQ15_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ15"/>
    <dbReference type="HOGENOM" id="CLU_111243_0_0_1"/>
    <dbReference type="OrthoDB" id="2551997at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="166" mass="18383" checksum="962A2DA59FADFBF1" modified="2014-03-19" version="1">MFSTRHEQHHVVHIGGAEFVPPMMTHFAHVPNLSLSTSPSSEASSSAASSPVHSRFSSSSTASSAADSLEEWDAVQAHLAYARRMADHTASMWQKERLAIEKAKLDGTYTGNMTSRQNGNARPPADAPAKENSEDKKKHKRFAWINNFLSPQSQDEPRGRSRSRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQD5</accession>
    <name>W3VQD5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQD5"/>
    <dbReference type="HOGENOM" id="CLU_1046344_0_0_1"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028110">
        <property type="entry name" value="TMEM254"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14934">
        <property type="entry name" value="TMEM254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="250" mass="27278" checksum="3FD25E91E7850416" modified="2014-03-19" version="1">MASAAASDDVAAKADGIISHMNNDHKDSLAYLATHYGDLLKPLKPNQVLMTAIDKKHLEIVYTTQKGAAPGKGKPGNRTVSIPFYPHIASYSEVRQRLVDLSAVSERVITTRKPDIVYRAPKLALHGLALIAVAYLALRSDTLASHGIVQSLVPESRLAQWNNLRNNTLGGPAKMDKFIAGIVRTHVLEGALMALVCYWKGASRLVTLRWALTTTALGIPAWIAFFSLNNHKRALKRAVILKDGTNKKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQF2</accession>
    <name>W3VQF2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQF2"/>
    <dbReference type="HOGENOM" id="CLU_447734_0_0_1"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="421"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="614" mass="67446" checksum="2D59691D654FB8D4" modified="2014-03-19" version="1">MSAPDYRYLQAWKRPSASKPSSSSGRGYEGPSSYEVILPTTDGDTATPASEPVQAKKKGKEEPQQSAYQVRLDTPGGISYAPDALAQHNSTKRLFIPATVHDRDAKEYDFAHEIRSRDAKNAKSATAAPAELDEQGRTAAQAYKESVEQDATSTASRKNADGDSTKPFDIPASSEASEDKEKRQSQVGTQLSKDDAASILTTATARSVQSKMTTLTLAAERDQTLPKNVTANAIAAPFRPPPSVSGDAAHARTPWAATGTWTTHRALDRLTDKEKKLGITQFEEATEGRVPSSYEASLFPSADTASDAATIRTLCAGELRVEDLFVPDPRPWRPLRYVRKVDPRQMLVLCAGAALTQGQVAAMKLGSDSSSVPTTDFGGRSSDAASVYSAVPTDFSVEATRKAMFASGKLPDYKALEAQLKSNAISAAVPGEAEEKRAGLGFVYCPTHDSRARQPAYRRTPEVVVEQNFSRRLERPPELCHSTLRRAALRAALAALEFHRWETEGFDKIVIATHHGWLVDGISRWIWEWRHNKWRIMAESPLGMIGEQVPDRDLWELLDRAVRAYEEIDCTVRFWKISKAQNAQAVQLASEGACKDNQQPQTVRWTKKKVQPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQG7</accession>
    <name>W3VQG7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQG7"/>
    <dbReference type="HOGENOM" id="CLU_027112_0_0_1"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="306"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42384" checksum="48654AC480A4D5B3" modified="2014-03-19" version="1">MLRPQAGTGLAEHSFNAQAQHFFRSNHILLNTSTTSISIRTVNMSAWGAHGKIGGSAAATPEDAETPILCEPCLGPNPYIRMTKDTQGKICKICTRPFTVFRWNPGAGSRFKKTEICTTKDLQVFRWNPGAGSRFKKTEICTTCAKVKNVCQTCILDLQYGLPVQMRDAALNIKSTGPTSDKNREYYAENMDKQLEGATSLVGASSSPAGRAGQELLKKMARKEPEYKRDRPVQFCAAFARGNCPRGDKCPFRHELPSEDTLASAAPATAATQPAPASPSATGTPKRILSSSTAAGLPPPADTSIVSLFISSLPADTTQDSLRSWMTALAPELRTEHIKSITLVTASRCAFVNFTSRQNAERAAAHCSPKMDWDNTTVRITWGRSRPTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQJ6</accession>
    <name>W3VQJ6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQJ6"/>
    <dbReference type="HOGENOM" id="CLU_023751_3_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="571" mass="62399" checksum="3ACCD176682CB776" modified="2014-03-19" version="1">MPAPGATMRLRLRADIGAPLHTALSSKRSADCADPSFPLKPFPSTSFPFRPVWLPAPQSPYSAFSLRSSGILSFDTLHHPTSLSGLFLFTACRRYKYPNLVPAVRPFACRLEPRSTISLGRAVWVDMRCLAQLLLLLVATTITLTTTANAWDWLPATDKNRTLDTTFVVKAAPPSSYNGPILTTAQQQGLNATDFYLYNYITTGYNATKIQRAVIMLHGLGRDAWSYFDQTHVALLNATSRKERTTHQSRLRADEVVIMAPIFLNQQDPGCYPVDANKQPNSTALVWNDSDWAEGADSIYPATVNDAQGIPFAAPGVSSFEALDMAVGRFANKTLFPNLNTIIVAGHSLGAQMVQRYALIGAVPSGTVPVHFVVANPGSYAYLTEWRPRSYDNCTDTFNDWKFGLNAYSQSYLSDFITDSLDSTNDVESVVQRYRRRIVSYLFGLADHGKGDTRCEALAQGTTHLGRGRNFVKHLTDMDGGFPAAHTVNYIPNVSHDGLGMFTSQAGLERLFFINLNGTETPTAVGDDDQSAANWQQAKKSAQHSASSAASERARLVAVGVVAVVVAVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQP9</accession>
    <name>W3VQP9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQP9"/>
    <dbReference type="HOGENOM" id="CLU_1741365_0_0_1"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="150" mass="17049" checksum="B39ED2080105660D" modified="2014-03-19" version="1">MSDTIKEIVDIPQNFFREGTHFVNRCTKPNRKEQTRHAPALVQEGIILPASSIPTNRSLSCFMSRLRTHQEYIQICRAVGMGFVVMGFIGYFVKLVRTHVSLTPQGLHRLQMPSRLVAASLRNRSTSQSTRSLCKFHLVASPQAEIDDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQT2</accession>
    <name>W3VQT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02914</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQT2"/>
    <dbReference type="HOGENOM" id="CLU_097262_2_1_1"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="52"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="186" mass="20019" checksum="BA6028EFAE96B9D7" modified="2014-03-19" version="1">MDQQDLQLLATEKHELLHAAQEARKLSYSPYSKFRVGAALLTKWGEIILGANYENASYGGTVCAERTALAKALIRSDALDVPETGSGRKVSRGDIIGVAVASDLEGSCSPCGICRQVIREHCSLNARILMVGCNWSKATAQQPSPAAVTDQGGKELNEPNVEVVTLDYLLPMSFGPEDLDKPRQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR02</accession>
    <name>W3VR02_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR02"/>
    <dbReference type="HOGENOM" id="CLU_033361_0_0_1"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57501" checksum="C5B18306A7D2A322" modified="2014-03-19" version="1">MVDDPSDLGHMIVSTCIDVSTNKSVDGSGTCWAVEVDAGKLWMTVDCNDRHCVQSSPLRDTADGTPFDRDEGEEDRLQNAFRSMYSFADAAWHSPAFRFPFSICFLRTSSTSLPLRQLLVAAAALSAVDALYSSSTRDTVRWVSFPASALPATAESFPKDDPKKPVHLTAMIGYKAGMTHIVRDLDRPGSKMHKKEIVEAVTVIETPPMVAVGVVGYVETPRGLRSLTTVWAEHLSDEVKRRFYKNWYRSKKKAFTKYAKKHSENNGSSISRELERIKKYCTVVRVLAHTQVRKTGLKQKKSHLMEIQINGGSVADKVDFAKEHFEKTFDVKSVFEQNEIIDVIAVTKGHGYEGVTARWGTKKLPRKTHRGLRKIACIGAWHPANVMFTVARSGQDGYHHRTEIGKKIYRISNGEDKTSGSTDFDTTEKTITPLGGFPHYGLVKNDFVMIKGSCPGVKKRVLTLRKSLQVHTSRRALENVSLKWISTSSTMGKGVFQTPAEKDAFLGQRKIKAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR63</accession>
    <name>W3VR63_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR63"/>
    <dbReference type="HOGENOM" id="CLU_302876_0_0_1"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="912"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="912"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="954"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="984" mass="107060" checksum="19C96D6C9201DE34" modified="2014-03-19" version="1">MAFGKDMDAWAGDTGLSLVERNEKKSRFSVSWAEAKLLTIAGVGFLMDAWDLFIINIIYSIILLAYYPKGTKNIDWGLQGGVLKASANIGNIVGQLFFGFCGDMFGRSAVYGKELLIVIVAVILQISAPDSIGGHGITIWLAVLRFVMGIGIGGDYPMSATIVSDRSSLRNRGFLLSWIFSNQGWGNLVGALFAVIVIAGYRHYVDAGQVHKLSGAWRILQGLTLIPAFIVLYFRLTLVESTRFTQARKLQDDPELIAKGHNNLNRSNSDDDDLKEKALGGDVTPIENTAVGMSFKSIGKPKNEFIEYFSQWKNAKKLIGCAACWFLVDITFYGINLNQSSILSAIGFTKGSTWGKLMKTATGNLIITAAGFLPGYFFTMFTVDIVGRKPIQFIGFLANALFLGILAGRFNTLKNQTGPFFTVFVFLQLSFNFGPNSSTFIIPAEAFPTRVRATAHGFCAACGKCGAILSSLLFSHLASATSLGNQGVFWIFFGVSVLGAIVTFFLVPETNGYDADEEDRRELAARAGVHSVTVRSMHTERGREDEEDEEAMRRSASANTAVKILDMLDALVIKALRAILPLATAVITPTQPPAPKPDVTTYIPSPFVPGKIPTKQHRRRLKADIYEPPGAPDDVALPVVINLHGSGFCFHTHGDDSRFCAYAARTLPAVVIDVDYSHAPEHPWPAAIEDVDSAVLFVKHFARENRKQRRRHGAVGATGRKEWLWDSDRIALVGFSSGGNLALIGSTRAEAHGGVQASVAFYPSTNLDEDPYDKPQLSPIKGAAGGTMPPWLRKMLYTCYVPIETVKDRKQPLISPLFADPASFPPSVTILTAEQDSLAREGTRLADRLEASAAYKGSVVHWQAEGQGHNWDKMTQQGSAAAQLKDEAYALAVGRIRDAFASVAIGYDDVREQEEDEDEDDADDAQDDSQDVLAGARSLSQLGRRSDAADSRPLSHSRSSLNTSTTAAGRDSLSRPATLKSPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR73</accession>
    <name>W3VR73_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP11-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR73"/>
    <dbReference type="HOGENOM" id="CLU_054226_0_0_1"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44132" checksum="226EEA2DBB7D7798" modified="2014-03-19" version="1">MRPMLSTALRLERLQRLQRLPAASLPRVYARPLHQASPCLAQVSPPLPFSWSHVKPNDASRNAEDAQAKAATSAPLPDHRLSVQSKRERKLREYEAKIKVKAMREGLSPEELQRRALESAKPSKAVGSPAAEAETLSEVEKRDQELAEAMRQRSKDEAAKKLASGQVHSTPTGAQEGPIKSLNKILDVEKLKTQDQETITKLWAGYHTIKNKLSAVIPTEKYLEMLANARKYPQFVLPLPRQVIDEESDSLDGASKEAFEMQFLEWAVVPNPAHPTLPPASTTLFTPLAEYKLKQDFSQPVLILTFYTDLCESNGVVLMRGEVTGLNEKTGKGGRIDQARAQLLALTLQRFYLPSASTSTDKQADQSECAQLLHDFHKRPEQFDVEQLVNVAFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR79</accession>
    <name>W3VR79_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Restriction endonuclease type IV Mrr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR79"/>
    <dbReference type="HOGENOM" id="CLU_074378_0_0_1"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34196" checksum="285833D61CE856AF" modified="2014-03-19" version="1">MSEPKFLNSAGNAQSVTSLILLPHPPNSVTAWRLDYSDNDAPVVRGFGIALSPKRPCTERPSSTSRADTVRNYAETSSAKRTRRSKLQLELNTEADEAESSTARGTRYELLCRDVLHQLFGMELTRTGGAGDRGVDLRGWWEPKTVPDQEASKRIRVLAQCKCQDEGGKKMGPVLVREVEGVVFRAASPSQPASPTGTGNADSANDVDLASDDDAPVAGIILSSSGFSKQALLQVRSSNVPLAAMHVLAQPQSTSDVGGKHLVERCVSIVWNDRFGSSHGLLPGGMEARWIRSLSPRQGAAEGTLGRPVIYRSGNPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR88</accession>
    <name>W3VR88_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR88"/>
    <dbReference type="HOGENOM" id="CLU_086118_0_0_1"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="207" mass="22764" checksum="0462323BFA0F0305" modified="2014-03-19" version="1">MSGQPNSDLAVEQQQPGDPSGYGGYVSAFENGMGSEMPEAPRDKFFRKMKEQPLVPIGSLLTCGALIAASNHLRTGNRDQFNKALRWRVGFQGLTVLAALAGSFYYGQKAAASVPAPPATPTDAPLQHGTVTTLPGRAPTQWQQNRAEERAYKDRTGFETRVDQALDRELNDDKRLEEALLGKEDLDSLRKPARERPVIGKDVRRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR89</accession>
    <name>W3VR89_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01404</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR89"/>
    <dbReference type="MEROPS" id="M67.A13"/>
    <dbReference type="HOGENOM" id="CLU_053034_0_0_1"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="12">
        <location>
            <begin position="62"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="363" mass="39945" checksum="794AFF32E2D783B5" modified="2014-03-19" version="1">MAAASSSAPSGGMAQATFELNNDIVQLDASTLDSIFAYDTEAQRAILRAQPWKSDPHFFTKVRISAVALIKMVMHARSGGIYEIMGLMQGKIDVENRTLYVMDSFALPVEGTETRVNAQNEAYEYMVQYLDDSKQVGRLENVVGWYHSHPGYGCWLSGIDVGTQRTNQQFQDPFVAIVIDPNRTISTGKVDIGAFRTYPEGYVAEGDKQGGIQSVPLDKIEDFGVHAGHYYPLEVEHFKSSLDAKLVDLLWNKYWQSTLAQSPLVTNRAYTTDQIRDLAGKLAQSHPGITTRSSAASNPFPTPPKTDDDKQVQTSPEKLLEQMASKAQSSTLANPAHDARKLAAEANHALLTTSLKSALFLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRQ0</accession>
    <name>W3VRQ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SPOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRQ0"/>
    <dbReference type="HOGENOM" id="CLU_020682_0_0_1"/>
    <dbReference type="OrthoDB" id="2556307at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834531" description="SPOR domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="64312" checksum="82B5DFC8402E2047" modified="2014-03-19" version="1">MWKSKTLILLHVVLVLMLAQSALAALKNEFPIFPLPEEVPPESQDGRSIYRGPVNEDLYPAVQRPAPIAQNLPSSKAGTRPTLVAADMARDRDGALVPGRPYALRLSPETKPTGWRGLLPNWKTGGVTSSTEQLQQLLRERRPLEAVYNPTAVPDTAALSRPYYSIKLPGNGRDAEVLKMMQKKGKPFYTVGAKGKVFYFDTKDGKSWTFTDKVSDADRQGVSANLEQANKQYQAAVAAEAEARARVQNRMLARQQAARAAMVAREGAASSSSWLQKIKGWFGSAPDVLRPIHPASPDNQLVITLIFSPSQSSSLSKPTWVVAAAGSSAASFNFHTMLGNILRASFLVHLLLLVCDVAGAPVQRGSSLPPILENSPFGAQPIGTDPALIPGLEAARARAALRRLQGQSAFAGPNTFLPGMREVTSAPAGKGSGSESWWPWSGSGAASTDAEINELLHASPTSRAGKDISTNPATVGRSYQAVKLPGEGMDALVVSRMMQQRKPFFVQGAKGRVWLLTLTGDFSAYRATRQQESVAALVRDAIKSWPIPTVAIRNTAVPQQVIRAGRSAEANAPLWEQLSDAWFGKVRQGVKYIRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRY9</accession>
    <name>W3VRY9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRY9"/>
    <dbReference type="HOGENOM" id="CLU_073203_1_1_1"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="294" mass="32010" checksum="0013C8095DA36353" modified="2014-03-19" version="1">MSKAPLKKSEWERQLSVINVAKDEVQRVDAETAVGSAATNEWQSIDLRPSVRNIALTLDPLIHDSDLNRLVMDYLVIEGYKDAADCFSRESGLKPFVDSESILNRMIIRGAIQRGDIDDAIGRVNELDPEILDNNPLLFFHLQQQRLIELIRAGLVNEALAFAAEELAPRGEEHPDLLPELERTMALLAFDVPKAAGVVAAGPLAAPAHVAELLSPSQRLKTAGELNAAILASQSQGREPKLPQLIKMLKYTEELMGPTGPGKLEFPHLDLEGALGIGSANDTHTAQPESTPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS18</accession>
    <name>W3VS18_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hepatocellular carcinoma-associated antigen 59-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS18"/>
    <dbReference type="HOGENOM" id="CLU_053736_0_0_1"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32413" checksum="737FB9E8ED12A479" modified="2014-03-19" version="1">MDSEAGPSSAPLFKKRSKPQRAARITTAIDDAPAPESTSTAAPTDPAADEELSVQDLIALRSLARRPGGIELDRLNRGDRQRRPNQRKNADEDSTKRISNRAGDDDSDDEDKPRLVRKNNFQGETGTVDVDKHMMAYIEDEMRKRTGSADTVDAAAIVAAVNDPEDALYAVAEKYKELHRSIKPEQTQEQREGNVAFSSAMLTSIPEVDLGIDARMANIQDTEAARREASQPKPAHHDVDEDFANARFQRAKPRQDHAQSSNPGSRPERRQMATDQLVLDRFKKRQRNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS32</accession>
    <name>W3VS32_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS32"/>
    <dbReference type="HOGENOM" id="CLU_455695_0_0_1"/>
    <dbReference type="OrthoDB" id="2546609at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="556" mass="61435" checksum="E29E3E76C31B110F" modified="2014-03-19" version="1">MTVHSPTAAQARHFRPVRYQTKEEIDRFFGTTPVQKREQRLRVREADGHVYFDWIEKDEWQHLLATGSLTSPSSADARRRSSTATCLTLNSPLTPLSPARRDSAAPGSASLSPLVVTFNHVAIDSTDSMRNRRRRKRSDSDVAMASNRVDNFLPYAARGERSFDWAPSPAFKRRQSDSYDPLDTLDAAFNREAEAESQHDGNKIRIKRLPLEHRRLDQHTLDQAFAVHDPLLDLAPDASLAGSRAHKPPTLLLPDPFRAHAQLEHDDACSTASSLPCSPNPSEYAYSTFDVGSHEPRRGTFGALEPPPRTPVQLVAAPPRRMRHHSDTAATPPSSAAMEVLNSPALASPKPQRTLRHAVSFDDAPRLPPLPVQEAGVWAQRQRWHSAGNESKLRAERSCASLRSQLSRRTRTLSESDDTACFTPLAPRTGAKKFDPTRHMILSSLEHLSDATSSVAEAPRIESEAEPAKAKVGTGLRTGAHVYDGVDIPCASIHLHSDPEDNFAPAIALSLSAHKLRKLRKKHSTPPPDSPTHSRSASLASHPKGSSRWWNHILHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS94</accession>
    <name>W3VS94_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS94"/>
    <dbReference type="HOGENOM" id="CLU_115154_1_0_1"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="136" mass="15437" checksum="597CCDBCE74BE2F3" modified="2014-03-19" version="1">MVLVRTSNANDALSGLSLAKYVQSSPALMRMLKPVANAYANATGHRQMGLRYDDLLVEESPRVQKALSRLPEREAYDRAFRLRQASQLSVLHRELPKDQWLPAKEDKRYLTPYVAEVAEEESERAAWDTVAVKKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS98</accession>
    <name>W3VS98_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS98"/>
    <dbReference type="HOGENOM" id="CLU_030571_3_2_1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="68"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="294" mass="32728" checksum="5CBD7FB9AEEE2B04" modified="2014-03-19" version="1">MSGQFSQHQLRDGVVLPAVLNKAPAGTKAHVICLGYLQADAGWFKRGGNTSLMSNPSGPEKPERRDLIMYSVLIEHPTEGLILWETGCGKDYPEVWGAPLNDIFARSRYEPEHELEAAIAATGNNIKDVKQVVIGHLHLDHAGGLEHFRKTDVPIWVHERELKSAFFSCATGADRGVYLPHYLSLDELNWKTFDDRTIDFAQGIVLHHLPGHTDGLIGMQINLENDGTFLFVSDHAHIMDNYKPGIPQGWLARDHPAWFNSNQRLQRLEKSTGGLVVPGHDLETVTPLLGRVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSN1</accession>
    <name>W3VSN1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease III homolog</fullName>
            <ecNumber evidence="8">3.2.2.-</ecNumber>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="8">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NTH1</name>
        <name evidence="11" type="ORF">PaG_00990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="8"/>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSN1"/>
    <dbReference type="HOGENOM" id="CLU_012862_4_1_1"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="284"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="537" mass="57672" checksum="EECE58C807741119" modified="2014-03-19" version="1">MSVTRSSSRRKLFAPSPLVSGRSVAVAAHSATVVTANGHSVAQVTGGASVEEDAAMATAIAVEESRRSYSLRRRSAAPLASPSTPKASPSSSAAKAPQQTRSMRTSAKRSRAQSPSSESDNYASGSDFSDDGAHSSDHDSDVFTDQKTNKSTPKAKRVAKASSKSAVKEETGSKPLSRSKSKSASPSKPKKAAVSPFDVSPRKATKKPLKVDLEPHEAHPAPAQWEKVYELLTKQRARIVAPVDTMGCEENGRSDRRADSWRESESSEDAAKRERLATLVSLMLSSQTKDPVTAEAVYNLQRNLPNGLCLQSLLDADDDAISSCIAKVGFWRRKTGYLKSAARILAADFDGDVPRTVDELCSLPGVGPKMAFLALSSMGIQVGIGVDTHVHRMTNRLGWHDTKTPEQTRLNLQSWLPRELHPHINRLLVGFGQVICVPTGPRCDLCNVGSAGLCPSYRPIDPKAAEKRVKVTLLADGEIHPAPLISPFKQEEQPAVKVEIDNSTPMHIADLTSDIAVKTEPDADAHDAAAVAKALEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSQ6</accession>
    <name>W3VSQ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00608</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSQ6"/>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_1"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="152" mass="16713" checksum="7F3FD06036ED53B4" modified="2014-03-19" version="1">MASEQTYIMIKPDGVQRGLVGEIIKRFEARGFKLAALKMVHASEEHLEQHYKDLKGKKFFPGLIKYMASGPVVAMVWEGKDAVKTGRVLLGATNPLDSAPGTIRGDFAIDVGRNVCHGSDSVESAKAEIALWFGEQTPTIAYTRAVDAWIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSV4</accession>
    <name>W3VSV4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSV4"/>
    <dbReference type="HOGENOM" id="CLU_1670126_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="158" mass="16708" checksum="7CFF91AC54D19E7C" modified="2014-03-19" version="1">MPPASSCSVALFSSRFQHRQRSNALHEEFLPSSAAIPHKQASISSVLCYSRSKGLLRKVELAQGVCEIAPSRTCVERLARSQCLLARGTTGHKLARVGPEEGERQRADRQPPSGASFTTVFRSVDLGGAPPLGCGSHSAASYSKRAALQPAAGSTAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT02</accession>
    <name>W3VT02_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01106</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT02"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="70"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="519" mass="57786" checksum="247907B5E0596D3E" modified="2014-03-19" version="1">MLSKDPQDESADRKSDILVVHNMDDASVQDQEKALPGRGADQETAKYAAEPTKISEAENKRLFWSINRRVLSIMLVTYFCQSLDKGTLNFASIMNIKEDANLKGQEYQWLGTILYMGILAGELPQNLLLQKLPVAKLLAVNVFCWGAVVACSAASHNFASLMVVRFLLGFFESTVQPCFILITSMWYRRSEQAVLTSLWYCMSGVQLMVGGLLAYGVAHYTNGVIYPWQLLFMVLGLATVALSVVIAFVLPDSPMSAKCFTEDDKRLMVERVRENETGIQNRQFKRHQVLEALTDPFAWCLFGLIVTANLVIGGLGVFSNLIISQFGFSYLQTQLLNIAQGAVTIIVMVGSAYVSQKWGQTCFTMLLWTIPAVVGTVVILVVKPTKNNAGGLLIAFYCTQFFLAQGNMIISLVSRNIAGQTKKSTVITMTFVGWAAGNMAAPQIFQTSDAPRYRKGFIAHLCIYGAYTMLVVVTRLILLRKNVTKRSAAEDSSNSDRIDHQQAFDDLTDQENRNFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT28</accession>
    <name>W3VT28_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress response protein rds1p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT28"/>
    <dbReference type="HOGENOM" id="CLU_029630_0_0_1"/>
    <dbReference type="OrthoDB" id="2098436at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833371" description="Stress response protein rds1p" evidence="2">
        <location>
            <begin position="20"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="44501" checksum="6299FDCF6D8A6617" modified="2014-03-19" version="1">MKISPSFVLALAAASSAAGSPVFRRQASSDMGDLPTPVSSAGSSATGRVSSAVRSATSTGGTALSGASSTVAPSSTSSASPAASTGSSGSSTFNDTQILQYALTLEHLEATFYNQSLSKLSSADFEAAGYNASVRNQIYSIGRDEAAHVDLLTTALGENAVPACTYDFSSVTDVASFLTTARVLEGVGVSAYLGAAKNISNSTYLETAGSILTVEGRHASYLIAQTNDGGNAIPGPFDTPLDFKEVYSLAAPFIQECPQNATLPITSFPALNLTGGAANGSFTPGQQVTVAYEANSTSGNSSYLALIQGVAQPQFLQLEGNSSQVTLPSNLTGGQMYAVVTSDNSGVTDDNTIAGPAVGYVNIPLPQAPEATNSSSSSSSASGGSTATGSAGAAPTGSASSAASASATASGSDSIVSTESASATATGSQSLLPSLASLGSANIPTPTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT75</accession>
    <name>W3VT75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT75"/>
    <dbReference type="HOGENOM" id="CLU_042321_1_0_1"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="183"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="500" mass="55141" checksum="336C06CFF90DA505" modified="2014-03-19" version="1">MSNRPSALPSANRWSAAPEPEALDWEGGGPTLERDSRRPNIIVLCARRSTSAAAKVEAVGTSSRTPAAGIWSVERRPLFFPFSPSSRLVDPHSTMSDGARATKLSFGLKPASSSLKSSAKPSRAPSALAFDDGSDDDQERRDVPEASTSSSNRGGARASANRRTDPLGTLSAKVAAPPTRAERKKQKEAEALDASVFDYDGVYDTIKEAERQVKQSKVAEDASKKPKYVEGILESAELRKRDRLRAEARMIQKQREAEGEEFADKEAFVTNAYKQQQAELAKAEELESKAEAKRRDTDKGMGTFYRDMLNDTSAARDAAIAASLTAQASSSGRSAPRDRERTDADLAREAQQKGLEVELNDDNEIVDKRTLLTKGLNIVSKKRSAGDTHGTAASERESRESRKERDQRRQEEYEARMNRDAQRSRQSALIEEQMLELERKRALEEDEASRRERSKIDARRNDSQAISDAKQRYLERKKQRLAATSVSASATASTSSSATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTL0</accession>
    <name>W3VTL0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTL0"/>
    <dbReference type="HOGENOM" id="CLU_045275_2_1_1"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="258"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="420" mass="46741" checksum="53716825E3333306" modified="2014-03-19" version="1">MADEEQAQHELPPQSPTLSQPEDTTASADAAPVPSTTQDSAEQPEAEQPNLDELRAEDGHGSIDAAPSTSADANSLTTVVRSENTDAAAQTAAIFDEDDEDDDQDLPSFRRREARDAAEDGTVRKKKRKRHHSPLGSPVHASATREPEPEPEEEEDPYANMTEAEMRRARTDRMIEEALRAGRKKAPRKRAGEDDLDLLADEEVAALRREMVNAADDDEEANKLKKPATNKLKLLPKVVATLQKNHLQQSILDNNLLEGVKRWLEPLPDKSLPALNIQHQFFQILERMTIDTISLKMSGLGKVVVFYSMCNRVEPSIKRSAEHLIEVWSRPVLKRSSSYRDRHVASAEWNPDVLARTSASASQIVDNGRRNVGIPQAVTAGFRVAPQSTAGQRSDSSHEARMANHKRLNQFKSRLKEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTM4</accession>
    <name>W3VTM4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTM4"/>
    <dbReference type="HOGENOM" id="CLU_544137_0_0_1"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="504" mass="56929" checksum="22CB0CE95B2CCFCD" modified="2014-03-19" version="1">MADIPLDYGSAEADAAADAAAVPMQDEAMDDGSRPDQASNSRFYALPTDQAVEAGAQRGPAPLTGNEPPTLDDITLMGTEEPTESPDPPAVEGGSDIRLDTLLIEGAPITQLSTSRLFAYLTHYGAQPLGLEWIDDQRCKVVFADERSARLALEYLCPSPASDEMQPVESDVTPLPNIDTLLEYDPDSWHSEFITSLVQPRKAHRVPAKLYTHVERQAALAEQESRTQMEAAVSELPDDVPEIYREMEQEERRNKLESREVRELRKLRSVLWLRHAVTDVDRKESRASTRSQWYKRHGYDAGREIVPKLLQVGQVAETKELFPGYEPSSSEPPRRRDERRSMLDELDSELDRHVASRTDEPERKPGEMMADVVARGDDDLMDRLGARSRRREPRSDSGRWGHDAYLANEDSRRRGRRSRPSATKMDEELDRHARQRHHERELSPSRRDSPSSSHVRVKGRGRMKAPASDGRWDDSPPLAQRMDSDAAPKLLKRIQSNSLASRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTQ5</accession>
    <name>W3VTQ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01407</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTQ5"/>
    <dbReference type="HOGENOM" id="CLU_274660_0_0_1"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:005416">
        <property type="entry name" value="Chromosome 10, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF30">
        <property type="entry name" value="F-BOX DNA HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="12">
        <location>
            <begin position="355"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1122" mass="123620" checksum="4523A75E93776781" modified="2014-03-19" version="1">MYPPHQKSAGPSSVASSSMLPAQSPAKRKKPAPSSSTDPQGSSTRTVPATTKAASTASSRPLKKKTVSSNDDSLAARLQPKLTQSSWRRTKSYQHVDLSGPTRRTVLEWLPREVVFMILHLLSFQDLNSLTRADKRVRPLVHAKSFSPWRKRLASFLHAERLYDETISLEEDSIFNASDADAPSDDEDAHAQATTNAVAATSASASRAPANRANSDHVQIEQTFVQAYADLVSALELKSAPVDLLDLVPCLTRVWHDHDSFTTIRKWCRDFVVGRTSADHILAAVDHITAIEVLCCVRLYLALVRISRAFAQDLPPLQSVRMLDYNLRSAVATFFKPSAIAQAPPPGAHLAFQLTHEQARFVNRDVRPGEIIKVQAFAGTGKTRSLLAYADRRPNKRFLYIAFNKAAAEDARRRFPAHVQCRTMHSVALCQVVRAAGQDIGDLRARDVVRLLGDSLPAGQLAKTQAMATQTGRDHRLTPTAVATYVLATLQRFFYSDDATIIPDRHVPTKVATDTDLKIRAVARCAQELWDLIRQGAPDRSGKSVRCPHDAYVKLLQLQAPHHSENYFKAFDVLLLDEAQDLSAAQVSILLRAQKHCGILIVGDVFQKIYGFRGGTAKAFNERLHPSSAHFELTKSFRFGDNVAKIATEMLGLRKPAPWERAAPRPVLSGALGTNDRVYAEANLFRDLLAPPEAEESQFPNETTQGDGAPSQPAARQTQAIGAAATQAQGADALAAALGEGGQAVALQVGSIGEMGRSEDILTHTRIFRSNRKLCLTALALSASLPQPHKIFLKTSQSLQPDAIVTLLRDAHILYHNDSRSMSRNSLLRDFASWKDLVQRVEAEGSGETKLSLAVALGGLLASSDFLDQVALLETRFAPTEDAATVVLTTVHQAKGLEWDCVIVEDDFRPVFGNDKTQRVEVASYWHQDELNHLYVALTRAKRNLIVSRCVMHWIAAMRGLYQYRLLPSNTNLSIGKLGLCPHCNGSKHALVVREYRLACFDFLNPKCNQHRPEYKHSREPCPPTDVVGCVGCLSDPSSAAHVDALADPDLAVFVSTAPKITRQRPQAPKPHDDAAEGKRDETAVGFKLEPAKHAFLNADHRSMKWAIMHHEYKRAVYSWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTS2</accession>
    <name>W3VTS2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTS2"/>
    <dbReference type="HOGENOM" id="CLU_094691_0_0_1"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="194" mass="21010" checksum="9054518AAD614F59" modified="2014-03-19" version="1">MLATRPLLSLGLGRSSASVSRLGLRAACIAPVRSALPRFSRMASTSTSAPTTKLSQQQNLDLLNEQRAKRPSSPHFTIYQPQITWYLSIINRITGTGLSVLLYAYFAAYAGYPLFGSAEALSSASLTDFVATLPVWFKTAVKVPLALAFSFHSLNGLRHLAWDWGYALTLKGVYSTAYVVMGATAISTLALLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTU7</accession>
    <name>W3VTU7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTU7"/>
    <dbReference type="HOGENOM" id="CLU_020537_0_0_1"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16792">
        <property type="entry name" value="SP-RING_Siz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031141">
        <property type="entry name" value="SIZ1/2_SP-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="147"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="338"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="589"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="764" mass="80334" checksum="95BABC77D150B710" modified="2014-03-19" version="1">MAADPAASGFADFALLADAIRSLTVAQAKALIKDVNNEPEAACGRLALSGNKPEIINRLITSLTERKNQGDIRGYQKFRTLIGRYKGMQHVAAAQSYNRTGLTSSTSTYGAINAARAYAGPAQSLGGIPANKASNVASSSYSPLASAGAPSSRPMGSAGAARINFKPSPFYEIKHFVSPIVQCPEAPTQNDRKNATLFVNLSAEQVEQLKGAKHQLRLFCTTVEAHAASLSGRNPATVEFPLTCEARVNNHTLSTNLRGSKKNVGRVPPPNLNKDGMLALRDGRPNRIDLTYTNAPKRHVLVAAICEITTVEILVERLKSQQFRTKDDVLSRMRREAEDDDIEAGAATMSLKCPFSYMRIATPCRSIHCSHVQCFDAYSFFSVNEQTPSWACPVCHKNIKVEELIMDGYVDDILKRVPQDEDSVVVEPDGSWHTSDGKVSSAGTAHATPAAEGTPLQERLLNSNDEDVKPGAGHGKSNGTRTPMDEIVLLDSPSPPPQSAASEAAQAPAAAAPAAAAPAPAAASAAPMVNGGSAPAARNGSSSSVTAPHKAPRAAALAALPERIELLSSSTNTSARQSPAVANDVIDLTLDSDDEAEPSVPTRPVARNGNHVHASHASHGGSSSSSSSAGPSHQGFAQFAPTPHRTGPFAAAMARAEATPEDEQIRRPGKRPRTDASEIPTPSDPRLANGRRAAGQSTAPVPSSYLDVGANGTGGREAGSTTANGAETAAPRGGDEAEDAWMDNADATEHEQYLNEEDWWSPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU19</accession>
    <name>W3VU19_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU19"/>
    <dbReference type="HOGENOM" id="CLU_1886633_0_0_1"/>
    <dbReference type="OrthoDB" id="10451402at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="135" mass="15306" checksum="6E81AA33AEA1E973" modified="2014-03-19" version="1">MKGKSPGSIQRGPYLTGDPVLRLGTRHCWTRQARRMTACIFLNPFVKLVFPGVVRLYHMDTQKRSPSADEATSGPGRNYLASEPTTDGDIIVYRLRMGTEKAKTYKALPLEERRQFLIDNYDAKIMRPSFNSLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU23</accession>
    <name>W3VU23_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU23"/>
    <dbReference type="HOGENOM" id="CLU_472614_0_0_1"/>
    <dbReference type="OrthoDB" id="2555811at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="577" mass="61690" checksum="99D8DE023E38B543" modified="2014-03-19" version="1">MSESTRSLTPAARSLAPSDLPPRKIRLRIVAPTPSLQFLAPFSHDDPDCFASLQRFVHAQLIKRARDADERSELENGGWEELAFEIDGFDVPFDDPDILRDGDTLHVRLHAIQPQHDEEEEDDVEEDDDEEDEAEDLERGMVDEDERHAVLEAARVAAMLRAGLHRMPTDDDEAARSTGEPSDLPRMPGAIAPMTRRIPSKASAKQSAVPPLPSMPLPPSSTGGGAAAAIAAFEARRKQMQRRTATSDSDSDSDSESSTSSSGSPSSDSSDSSDSSDSGTLDSSSSSSSCSDSSDSSSSSSSPSEEATISHRATPGTGTVTGTGTGTGTTDALVPPGQGTSRTKRRNQMRRLKQQLSRHATSNGSGNDSAWVDDRTPAYRIERTAVQPAPVHTAEMPPGAGALGIDDCAPRKRKRDATPDTPGVGVRHIDCDAYYDSQLTTLQARPSQPADDVEGVAKRVKLEPDEIAAPASGEVEAAWTRVYAITPAQLSRFADGAVATMDTLKVGVPLVVRQLALHPHTRSPANLLHAAVVSSVANSHIQVQIKGPFLDDDTQWPDSPTESAVWTQSNLPLAWHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUR3</accession>
    <name>W3VUR3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2461 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUR3"/>
    <dbReference type="HOGENOM" id="CLU_036742_3_2_1"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52247" checksum="12B7C24ED2DE5239" modified="2014-03-19" version="1">MLDCLRNARQTRPRLGHFRDPNFRDPFLALHRRSDAQTLHRPAARLLSCSDVISNKLSSAAQASDLHLTPTPAELNAGEMSSRRSARASAASRQSYREDSDEDHAAPDDLTEDEYEQHDAASAEDDEPEPEPSDSDEQRESSRSAKRRKTGSSTPSSRAAASKAAQNSDWAPGVTRVVAKLVGAPTTDHVPKGELSPNVLRFLSDLAANNDRDWFAQHDAVYRYCWTNFGDFVSAVLDDIMTHVDPTVPWLPTKDLVYRIYRDVRFSNDKTPYKTNLMASYSRGGRKGPFAGYHVLIKPGGRSFFAAGRWQPEKEDLAAIRQHILENTDQAQALRQAVQEPSFVKWFGPPKLNADSKVKAKTKSKPDQQRCNLWGGDDELKVAPKIAGVDKTHPDIHWLKLRSFCVIHTFTDAEVLSKHFRKRLIEAAKVSEPLVTILNSITSPDPPSPPASDGEQASQDEESAEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUU3</accession>
    <name>W3VUU3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUU3"/>
    <dbReference type="HOGENOM" id="CLU_531130_0_0_1"/>
    <dbReference type="OrthoDB" id="2553003at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="513" mass="55295" checksum="30142C9C54F3992F" modified="2014-03-19" version="1">MPALERLYLPPSLSAVASKGRRLFSRDSASDGVQDKPSALNLNEALEQGWSAAASPHCLSNQLRSPPLSSATHASRGGKDFGRRRSSNATTTSTSSDGLANDGVQRRRKSLFSKKARSELPLERELDERAAWGAERFIDPFAQRGFQQDQDSLDLSCGNGRIAERSSQRFSTQRQEQQKRAALERVSDLVCLAVENQMAMSNQPTAPSSPEFQSPSSTLFDTLSYQDASTSWPTIADTPAEASATGGTLPMQSSAQRMARITSSEGLDVADAASCSMSPSLSVMSTADSYATGPSLATWDTLAEPMLAQVGGLTVPWSAEDSMFHHQILLPSSMKRMPSATARIDAGQRSYASLKAQTGHGFKSKPYPREPCKSRAYSPPPPEWTGLTDGCASLPLPPPLRPSRNPLRKRSTSLSATEARRQAKDAHDRAASPPPPLPSPPPQVERADEVAMQSQCAFAFMQTPPRSRRSSEHRPRFTRCDSLTSAASSGSLNAAPFHTPTFGSQSWSSLPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUV6</accession>
    <name>W3VUV6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUV6"/>
    <dbReference type="HOGENOM" id="CLU_046727_1_1_1"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="8">
        <location>
            <begin position="127"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="310" mass="33747" checksum="DAA0E5DF91DAC798" modified="2014-03-19" version="1">MAATNGHANGSLDPYTKTCQDVSGPNANPRAKFVLDSLMKHLHAFAREVQLTNEEWLGACDLLIRSGQMSDDRRNELILISDVLGLESLVDSMAYERAQASSSSNKPTSDVEATQSAILGPFFRSGAPKYEAGADIVLDHSIKSKEGKTGETCYMHGTVTDAATGKPVVGAVIDVWHTGPNGLYEQQDPDQPDFNYRGKFTTDDNGQYALRCLRPTAYPIPYDGGAGDILKLLDRSPMRPAHIHLLIEANGYKQLVTQIFDSKCDYIGADAVFADKSALTVDFAQPTAPEAKKFGTHTEVTYDIRLVADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV06</accession>
    <name>W3VV06_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV06"/>
    <dbReference type="HOGENOM" id="CLU_014017_2_0_1"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="317"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS65320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="637" mass="67444" checksum="FB7FA290F68A6332" modified="2014-03-19" version="1">MPDAFFQKKRKRTSASGAGARAGPSRSKPSSSASSSRMRKPNADSDAEDDDAAGGIDDMDLTHNYNHAPNSDDEAEAAETPAEARVRLAKMYLQGLSDSPAGDDFFEGAEQPSFGLADAAQADRDNIAARLQKDVAEQSGKIHLFLANRIAVSPTADDAQSGTVLTVKGHRLSVTAAVASADAKWLFTASKDGNIIRWRMSDGKMVRVLPRRARVLDDDGQPVPPSAASRSKTSGAARRRARFTAAAAAANGDKGKTSDGADAASYLGVGAEQGHTDEIWSLSVSSDGSRLASGGKDARVCIWDVAPRAGETFLKALGGHKDAISAVQFRTGSHELYTASLDRTLKLYDVAQLSYIETLFGHQESVLSLSCLGAETAVSAGGRDRTCRFWKIRDESQLVFRAGAKSKLRDVLEGGDLARQALSGEGKMSAPTEAVEGSVEVVAMIDQSHFVSGGDSGSVSLWNLGRKKPVHSVPVAHGFDLTTSESEGDIRTPRWITAVAALPYSDVFASASWDGNVRLWRIVAPGGSIRSFEPLMSVSVQGVVNSIQLVQPPLSSVRVSSDGSLSTNALVASKWKHAKGAVETEGKGLTRVTATKQNAPPLLIVAAGKEHRLGRWIKLPHATNATTIIPLTLTHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW72</accession>
    <name>W3VW72_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW72"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="513" mass="54804" checksum="18C4BE904FCFB8DF" modified="2014-03-19" version="1">MSPAPTSDSATVDFISASTLPCIIDNAAYTTSHTYAVYRTDQSSDSERQVTHHVHAVSPAEAKLAVDSAAAAFPAWKATPVSRRREIILKAASLLQERIPQYAVNTMQETVVSRGLAGFELGVLGLGHLTAAAESMTAALKSEMLPPGEDGAIKIVRREPYGVVLAIAPWNAPFVLGLRSVLYAIAAGNTAVLKTSEFAPRVHLSVAQILIDAGLPKGVLNVVHVDPAHAAEVTEALIAHPRVRKVNFTGSTRVGRIIAATAAKHLKPVVLELGGKAPLIVLEDADLDLAANGILFGGYLNSNQICMAVNNVLVHKNVAPKLQQTLTAMFDQNREVFTAKLAQGMEDKHAMRSLFNKASADRLQVLYTDAVSKGASVVVGQASFEGALVQPIVLSPVTPEMSIYTQETFGPVLSLITFDSVDQAVQIANTPEYGLAASIYSTNTMLALEIADRIDAGQVHINAQPVHDDPQMPHGGWKNSGYGRFNGPEGIREFTQTKGITLQHGHPTPFHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWX5</accession>
    <name>W3VWX5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWX5"/>
    <dbReference type="HOGENOM" id="CLU_302506_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="683"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="786"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="982"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS65261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1027" mass="112965" checksum="A49A3AD6C09B985E" modified="2014-03-19" version="1">MACSRKAAGLPRPIYRLARAGGASTAAVVSTPMLPPAFLAPAAFTQAFSTQSPARAVAPRSQSRSQSNGPTVSSAHNLKAVLRRLGKSNKWSETAPDQSLDSPRGRQERESRSVVKHPGGKAREPRSSVKQSGGKHAGAVARSDRPRRSDDGERSTQLGFRLRAKKLLDHLAAADRAIGEAARPGTDVNAALDHFDNEMRALRVMVKSKDVLIDPDNAWKSASRIKAPYNAAIRLCFRAGRVERAIKLVNQMKKDGIFPSASTYTIVIQGLSRMHPRHHLSSAAGDSVENETALQNLTQRAEQAFEELEKLWQQAFPQYFQRGSGAPPFKSILTIDEDSFHKLSDQARRNLVSQQSSVHEAQQFPRLLTNAINSYLNFLRCIGRSQDQIKILDRLFPSALIERLARGLAPDASSQDKLELANRKLSDCLPLGHVSTFTPILILHRDTRDREHQAVFKRIWTLCLQLMEIERQQATMHTPQADPPRRSRSKADAAEVSEAASRTSEFRFRPDDRLVSDFFIRTSNSSEVDAKSNMRLGLSILARVYGLDLESTADGIVRDPQSSSFSDSFGPARYLLSHDDIEQGCDRGFAELKDGRTAGSVLRGLAVAQPWQHFVALFNYLWSRAHSEDHGGSEQRDALLDATADKPVFGDLLQASNALRLLWVLGDAGDPVGARVILRGMKRAAAQQAGPSRRRSGDRRARPSDSSEEEVQDWEPADLSYVRVMRAIMVATQRRPAGLTAAIVKEAAAPEPHADVASHASKPSYDPWTEAKTLLVEFSARKANGGSVRAKSQAAGHEFGTDGRGDTASRRQLEAPERAPEWMARIHLNAMVSFFLNIAHVCAAKHANQGDLIAREALTLLEEKFGLEELVRATRKLQNEMNATVADGEASAKTLPARRLGLLNNLGKVTALALDASNHSFAPKADVETWKGVRKLLSTMSVFEESDARPSAPVGKMRGGLAGNHLLLSKDDYLELEGEADSEEFEKQAFGEGDSQGRYGARGSQRTQRRSRHVEQELQRWVRGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD29</accession>
    <name>W3VD29_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD29"/>
    <dbReference type="HOGENOM" id="CLU_112588_0_0_1"/>
    <dbReference type="OrthoDB" id="2552749at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="233" mass="25169" checksum="D5583EECA216FB3B" modified="2014-03-19" version="1">MATMPYQYLTFSDLYEEEVRSSAPSSPVMGATASPSLSPVFLLPTAPAGSTYRHNHASSSHHHTASRSHSHSRRRADVHGHAMLQTLTQDSDDVAAPITGTSHSAAASASASSGSHSSSSLHLDFLKVFKRRTSLNKRRKDSHTGSDSAFSTPASSRRSSFTSHGFASLHPVSAASSANTSPAISRQVTKVSDYDALVQRTARQEHDEELQRQSELQAYFNQAAETGLSLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD99</accession>
    <name>W3VD99_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_06424</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD99"/>
    <dbReference type="HOGENOM" id="CLU_003818_3_1_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="75"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="457"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS59505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="684" mass="77142" checksum="46C066931701D745" modified="2014-03-19" version="1">MAATTTTARDASKSAKKRNSKAQPSSSETSSSSGRKAPSGRRANSTWRLLSWTCSAALFLLAYLTYKNDGQLPTHLLRPNSRHSHPPPTHQQHPFSPPPSRSDASNDWNKQAHLKPPTDKRAPSLAYPLPPTRPLPEQPLRAADKDRQAAVLAAFNHSWSAYRRDAWGYDEYHPISQHGSNLSGKEGQGIGYTIVDTLDTLILLGLKDEYEEARDWVQNELSWDVPGRMNVFETTIRTLGGLLSAAALIRDPPHPAFAPNEDDAQMFIARAVELADRLKPAFDTPTGVPWREVDLETGEAFPDLNNNNSSSLAEATTIQLEFKYLAHLTGDIEYWRIAERPMEVVRKATAMLSHLQGLLPIFLNPLNGHFYNGEIRLGSRGDSYYEYLVKQWLQTGRTEQVYRHMYDGALRGIKQLLTKPSVHSRPPLMFTAELAPRRAMDGRPYMQLVPKQDHLVCFLGGAMMLGSTSDVDIFGDVAKRPMPPISDVGKGDETDKEDWRLGHEFVRTCMDTYTNTKTGLSPEIAFFKTPQDAKMSDAQMIAANRAPLPKNVDWYIKKPPPSYQGRPNPLIDARNILRPETVESLFVAFSLTGDEIYRDWGWQIFEAFERHCKVESGGYSSIDDVDADEPRQVDKMETFWLSETLKYLYLLFSDRDLLPLNKWVLNTEAHPLPVFEPTFPTGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDB0</accession>
    <name>W3VDB0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_06557</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDB0"/>
    <dbReference type="HOGENOM" id="CLU_007727_4_3_1"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="110"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="13">
        <location>
            <begin position="471"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS59633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="738" mass="81352" checksum="314124B0A2BD5316" modified="2014-03-19" version="1">MAESSRSAQWTNGQRAIVVIDDDDVAMPSASTYAAGRQAHSPAGSLTNLTPAMSVTTSSNSSDDRDLVGMTNGIGLGAREEASGALDEFRTGYVYSSEMMLHSNPIDPEHPERPVRIYKIFRKLQENSLLQHMKRIKIREVTKDEVMLVHDQGIWDGVERTALYHPDIIKEQVPRLENLSSLYINEHSAFAARLSCGGAIELCDAIASGRIRNGFAIVRPPGHHAEPNKSMGFCFYNNVAVATRYLQQKYPQTIRKILILDWDVHHGNGTQRAFENDAEVLYVSLHRYEGGAFYPGSKYGNYDSAGTGPGEGKSVNVPWPTKGMGDADYMYAFHHLVMPIALEFAPDFVIISAGFDAAEGDPIGESRVTPGGYAQMTHALTSLCDGKVAVVLEGGYNPDAVADSAHAVTEVILARRTVEPKETVASTIAANTVREVCRFHQRYWKSLKVPDLEADDVDFDTHDAPPSVCIEDLLSEYRNSVLSDRFDLFEVPLPEADVHFSGQVLCSEGILERFATVVFFVHDMGNLRSGRPRLGSTIEGEAMRLVDASSLVMSYVRDKAYGLVDMNIMREFRAVKPHAHDAMPRAALSDDTDRIAEANEAAAFVWDNIVSLARASTATKIVMIGFGTGCDVLTSLIQARDVETQVKAVVNIVGYNEMPRIDPTAELAKKKWYYTKSKVLAPADHRHILERGDSVPLKRFGKITPVDDVAPINILSHRFGEITSFIEKKLNLPPRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE76</accession>
    <name>W3VE76_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cyclophilin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cyclosporin A-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_06338</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE76"/>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5 12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="33"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS59810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="403" mass="43240" checksum="8787DFF0EFA94A58" modified="2014-03-19" version="1">MASGSTSAPTAGNPIVYLDIQFGDQPAPSRAGANRIVLELYKHLVPKTAANFQQLCTGSAGKSASGAELKFAGSTFHRVIPKFMIQGGDFTRGDGTGGESIYGEKFEDEDLTGKHDQPFLLSMANAGPNTNGSQFFITTVPTPHLDGKHVVFGRVLKGKSVVRRIENTPTQSDRPVEEVKIAHCGELDPESAEVKEGSYGIANDESGDAFEEYPEDQGGELEASVEKTLEVATQLKTIANTRFAAGDHAVALEKYLKALRYLQLHPVLPDDTKEPTRAAWYTLKTSVQLNASLAALKSAPAQPRVAIAQATAVVQFLTSAQATSWDATPEAGAKRNADLAKAFYRRALAYGASKDDDRADADLKRAAELAPTDPGIKKEQAALAKRREAKVKAQRAAYSKMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEV2</accession>
    <name>W3VEV2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEV2"/>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="146" mass="16250" checksum="73096497EC9AE9D0" modified="2014-03-19" version="1">MSDDEHFGSAGAAAVDDELSLPKATVQKLISELLPKEVTCSKETRDLLIECCVEFIHLLSSEANEVCERDSKKTIAPEHVLKALDDLGFPGFIQEAKSVLSEHKAAQKDRERKTTRMEQSGMSEEELQRQQELLFAASKARFEAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEW7</accession>
    <name>W3VEW7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_06102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEW7"/>
    <dbReference type="HOGENOM" id="CLU_072440_3_1_1"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="172" mass="17996" checksum="DD0D92C285F947A5" modified="2014-03-19" version="1">MSFTDKIKAAIKGDVKEGAKLETGIKLKESNPENADVSLDNLTGKTIIVGVPGAFTPPCSSQVPGYISHAGEFAQKGVQAIYIVAVNDQFTVAAWKEKLNGASAANVHFLADDTGAFTKAVGQSFDATGLLGGHRSKRYAFVVEGGVVRKAFVEDNAPDVTVTAAENVLKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFH4</accession>
    <name>W3VFH4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05609</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFH4"/>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="153"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="465" mass="50912" checksum="E479FDF09304B9D8" modified="2014-03-19" version="1">MTAAAAPTNGASASVDKVADQLAQTNLPATNGNSNGHTNGHANGDNEEDGDDNDDDDDDDDDEDDAGAAATTGAAKKKKKNKKKKKKSKAKLTQTVPPRVGLTKIFTNGKFPVGEIQQYDTSKFSEERKRVTDEELRERERIVQQEDGFDYNIIRRAAEVHRQVRQYAQAAIKPGMSMIEIAELVEDGTRALVEAEGFESGIGFPTGVSVNECAAHYTPNAGDKRVLQATDVLKVDFGVHVKGRIVDSAFTLNFEPTWDPLLAAVKAATNAGVKEAGIDARLGEIGAAIQEVMESHEFEANGKMHQVKCVQNLNGHSIERYSIHGGKSVPIVAMPDLDVKMEEGEYYAIETFGSTGRGYVIDQGECSHYARKARLPKSIPIRVHSAHGLLRTINKHFDSLPFCRRYLDRVGEKNYLLGLKHLVSLGVVQDYPPLCDVADAMTAQYEHTILLRPTCKEVVSRGTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFV1</accession>
    <name>W3VFV1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin cytoskeleton organization protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFV1"/>
    <dbReference type="HOGENOM" id="CLU_008075_1_0_1"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="94296" checksum="643149B165FF149E" modified="2014-03-19" version="1">MAFNPVAMLAERTCAPIYNAIDTGNNTLAVRHADRILHTQPELALASALKALALVRSGKRDEANTICTQLIARGISKGHENALTPLTWCLGRLGRRQDEVALLETAVKNNPNDEDLARQAFLALVKSQSFQKAQQLSLKMHKSFAQRKQGKGRFADEYFWWSILSYVLLARDAKAPGAALALPLSQRMIEKQIEAKPLGLNDEEALCLQLQVLVRQGKKAEAFELVATESSVGYTLCDRNLSLEFTRTDLAKELNKWQYVEQSCWARIDGGSRNWAHFTGFLDAAEKRGKDELMAAHKKINVLLSVKGAVKDRSVRLAELEVWRKRMQAEPEVEAQLHAKVVAYFDTFATKACCHEDLLPYLRALSSDSRSKLSAALKERIKPLPAKTEAELRTYISIAKITRAVQAESSLSEGSEAALAAELVARYVDGLSVGKDLPDTEMQPADDLALLGAQALLSAYRLSGGKLVYLFQVIGLLEFGLTKSSKGYQLRMLLIRTYTLAGALDRALIHYGLLGLKSVQADTLSHLVSERCSAFSATGKNAKAADEATYKMAVRTLSTAQAIYEENAGSTPEMIGKALEHGIYSRVEEFVEFGEALERSLQRQVVRLEEARSHLHRRGNFADDEQRKTFEAAISNSVASVRADLAAGLSDQRDYSVLVNYQPMATPSVEELTQVGQRQDAGWVRSIALTLADDQGGVGIEEQDLQTLTAREKALVQLMASARNGSFEASRLLELLEAVKTTARTVVDVVGGGAGGGERVARPVDAVHEAALALEAVYHTEALLDAESKAACQTHLAELATLVNHLTRSTQDTTKPAVLEQGLAAVGAERVAQLMQSTRDNVARCWTKVFANLRDALRDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG09</accession>
    <name>W3VG09_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000035">
        <property type="protein sequence ID" value="ETS60450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG09"/>
    <dbReference type="HOGENOM" id="CLU_2172130_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832943" evidence="1">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="110" mass="11997" checksum="CF8F52FB72FEFF5D" modified="2014-03-19" version="1">MAKLLALLLVITPILLALEANATQAGLPHLHPRMVKHRKLEARNLMSWLTKISSKASDWMWGSVPNPVKDSSRIPKPVVGGPDVMPKMPYPYATGMIPRLASETMAGNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGB2</accession>
    <name>W3VGB2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGB2"/>
    <dbReference type="HOGENOM" id="CLU_015284_3_0_1"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000428">
        <property type="entry name" value="Probable SAC6-actin filament bundling protein, fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="114"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="262"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="386"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="508"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="616" mass="68681" checksum="C2A55417C9A89EAE" modified="2014-03-19" version="1">MEAIKLQRKYPQFSQEEMMGLISRFRTLDVEEKGSIPKQDVIKAIQDQGDASYDQVRETLKEVDLDASGRVELDDYVDLLAKIRAGRNASAGVVTKGKVFVKGATSSTQHTINEDERSEFTRHINSNLAGDANIGARLPIPTDTFQLFDECRDGLVLCKLINDSVPDTIDERVLNFGKAGKPPNAFQMTENNNIVITSAKAIGCSVVNIGPQDIIDGKEHLILGLVWQIIRRGLLSKIDLKNHPELYRLLDEGETLDDFLRLPPDQILLRWVNYHLKAANWHRRVANFSKDVSDGENYTVLLSQLKPELCDRAPLQQTDVMQRAEMVLQRADAIGCRKYLTPGSMVAGNPKLNLAFVAHLFNTWPCLEPLEEAPPVEIEDFDAEGEREARVFTLWLNSLDVEPGVYNLFEDLKDGTVILQAFDRVIPGSVTWRRVSKPKEGQELSRFKAVENTNYAVDLAKASNMHIVGIQGADIVDGTRTLTLGLVWQLMRLNITKTLSSLSKGGRGVSDADMVAWANNLVKASGKSTQIRSFKDGQLRTAVFFLDLLNALRPGIVDYSLVNQGRTDDEARMNAKLAISIARKLGALIFLVPEDIVELRQRLILTFVGSLMAIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGQ2</accession>
    <name>W3VGQ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carnitine/acyl carnitine carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGQ2"/>
    <dbReference type="HOGENOM" id="CLU_015166_16_0_1"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="221"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="32812" checksum="1C0A9FB1FE6C732B" modified="2014-03-19" version="1">MADDQTTAAIKDEEFEQKKQATSSVKSFLSGGFGGVCSVLVGHPFDLTKTRLQTAANGTYTGGLDVVRKTIKADGIKGMYRGMGPPLIGVTPIFALSFWSYDMGKKLVYAMTPGRTDPKLSTGELAFAGFFSAVPTTLVAGPAERVKVLLQLQGQSGSTGPTYNGPVDVVRQLYKEGGLKSIFRGTGATLARDGPGSAAYFCAYEVSKRMLTPAGQDPQQLNFLNVLTAGGLAGMAMWGLAIPPDVIKSRYQGAPHGTYSGFLDCARKTVAQDGVKALFKGFGPAMARAFPANAATFLGVEVSLSVMNKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGS4</accession>
    <name>W3VGS4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04661</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGS4"/>
    <dbReference type="HOGENOM" id="CLU_085752_0_1_1"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="49"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="137"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="203" mass="20763" checksum="CED5A6BE504AA252" modified="2014-03-19" version="1">MVSTLALASGSGLTTLSAIGLYMLLTGNGEAFNIGAFLEETSPYAWAMMGIGLCIGLSVIGAGWGIFITGASILGAGVRAPRITTKNLVSIIFCEVVAIYGVIMAIVFSAKITGNLQGGTDGLWSPNNYLTGHVLFWGGLTVGMCNLCCGVAVGITGSNAAVADAADPQLFVKILIVEVFSSILGLFGLIVGLIMTGSAEEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGS6</accession>
    <name>W3VGS6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGS6"/>
    <dbReference type="HOGENOM" id="CLU_034228_1_0_1"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:001125">
        <property type="entry name" value="Mitochondrial transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS59936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="583" mass="64056" checksum="42E5573FDAD92208" modified="2014-03-19" version="1">MGLVARTASSAVAQLASGLRPSASRNTRRIPKLHTPMTARTLYSSTAVASSSKTSSSSKEQQSSDASDRADEPAPKSKRKRRTSEEVQASRLASKTFGLPVRATRRTRSSIPGAPGHEAGKAHEMVGPSTKSARSAPGKKAAGKKKTADDAKHDERGSELDNPWRDAESIGELLELMSYDHLPPRPEWKKAFPNGKIQQTTYRYFVSNRSTIQQIIPHLGIHDPERNGEEVTIVEGYPGPGTFTSELLKIPEVEKVVALEATPCYVDKLEVLKTQLEQQQPGGGQRLDILQSSAYAWETYGDLIKSGKLAHLNGRVARTDGGTVDFTRDDSIPPDHSDASWKKLSPVIFLAQLPNTVYGEQLFAQIVTGIASRSWLFRHGRIKLAFVCGESLAKRCLAPAGDKMSRGKLGTTVQCLADIEVHRYAHELQPHATHFYPTAMTVGPRVTVSGSSLIPNSNSSTGLTRTGMVMMTVTPKQKPLIKPNEIEAFEYITRNLFILRTKAVGEALTHVAPGAQNVLKMTSPEQVEAKLIKKDEVILPSDIVADLTNVQWACLAKMFEKWPFRPRHLFEEGRIKSDKDRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGT8</accession>
    <name>W3VGT8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGT8"/>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="33"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="489" mass="52205" checksum="D126ECA3FD69BEC1" modified="2014-03-19" version="1">MVNATNMADGNILTNAVVAGEPTDIIYNLGNMAWIIVSTALVFIMIPGVGFFYSGLLRKKSALSMLWMSMCLMAVVTFEWFFWGFSLAFSPTSTNKFIGNLDNFGLMGVDIGPSSGGTVLPQLLYCIYQMMFAAITVVIACGAFADRARLGPVMIFAFCWTTIVYNPIAYWTWNVGLGWSNVMGGLDFAGGTPVHISSGTAALAISIFLGKRKGYGSEQLAYRPHNVGYCILGTVFLWFGWFGFNGGSALGANLRAVQAMMVTQVAASVGALTWMFWDWRLERKWSAVGFCSGAISGLVAITPASGYVGTPAAVAFGVVGGTACNFATGLKNVLGYDDALDIFAAHGIGGMVGNILTAFFADNRVASFDGSSPIPGGWINHNWIQLGYQLADSASGFGWSFVLTLILLFAIDRIPGCHFRASEEDESLGIDLAQIGEEVFTLPLLHDFHRPEEGAEVSHAQASVDAKFSPANSEKDLEAAHAPSTAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHJ0</accession>
    <name>W3VHJ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Paf1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHJ0"/>
    <dbReference type="HOGENOM" id="CLU_394817_0_0_1"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="564"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="76074" checksum="A0F0133C229B0AF7" modified="2014-03-19" version="1">MSYSNGGANMQGAGAAAGSGVASASAASTSRSRRELIDRVKYPNPIPLPPYPPKLVKIPAEPSRYANAHFADRLASQQPVPLIVDVHAGMPIDLANFQNLWEGDLSEVSVPATASLNAQDLDDADAFLLQDFATNLPAAATTNSAPGAIGLITSLNATDDPASQAALAAALQQRHTQSLGPGAKAALAADDVSWLRRTEYLGTHLKAQQQVQKPKVTQRIDISREAQLAKIEQSFKDAQQPLASLKHPHKRGVKAVQVFDFLPDPETWATNYQVVRFIDPPGRIVNGVPQPDPRLDVAILRPVSAADGEQRVSYYLPAGEDIPEDPEEPMTLLDNPDKEENNARRLRKRRRTGKFPIPPQDEDQAESSPKLLKRDYATAYKLARDYVPKDTAETAHDVLVLTLDDGVPDADPDANFDPIKGAVSAPANPADEDDDDLFGDDDDEDTSPKGDNAGDHIDSTLPPQSESERQKRSRRTAATKGKERSEQPAGDGLTSTAPPKARAYYHKVGMRFTLRVWRSRFANNEKLRNRDRRYPGKWDAILLANRELTEREKLRRLHARSNVDDVGHLDPYEPSDDEIEEVVEPADEHAADADAASQEAERDEPRADANGDADADADADGAASDNDAEKSDGADDDDDEDDDDDDEDGTVDGDEELAALRAEAEDAGEDLDVDDGARRPRSRRSAPSTDAAAAMEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHQ2</accession>
    <name>W3VHQ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_05158</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHQ2"/>
    <dbReference type="MEROPS" id="M41.007"/>
    <dbReference type="HOGENOM" id="CLU_000688_23_0_1"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CARD" evidence="18">
        <location>
            <begin position="963"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="277"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1010"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1017"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS61198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1063" mass="115540" checksum="2BA8480DFFF2433B" modified="2014-03-19" version="1">MYQSSIVDVKLVCGTFAALQKAVSQRCLQSKYGNIVGHGKTFDERSDKQQKADGKLLYGKPVRRMPAYLAVEDAAAGIIRLGREAQPDIDLDILESAYPIKDFGSDLDEGRERPQGGKKASSDADLTSPRNSRVRRLSSAIESQEGLVTRATLRSKELGGFLHSPSAGTIQASQSVVGDTNLSSITTTTTSTLIIASFAYLDYCYSRFRTAGSSRSAVSRFGLAPSRSAQISAALPSTAATRSFTHLSVSGSQIASSSRSNAAKLALNKSALSLQSRQYATPAEEGEKKKSSAQEHDEDDKKKKEFEESVERGLKEARQGKAGGSLPENLKQFFDSDDKKARASKSDKEPARDEDDEVAEKKKKKADKSSGANGSAGGGPNGQYTEIRINANTIFATIVSTYLLYRLTSPDQPSREITWQEFRTAFLDKGLVDRLVVVNRSKVKVYLHSNATGSMYPSSGGSSSPASGSGHAAYWFSVGSVEAFERRLDEAQRELDIPGNERIPVAYHEEISTASTLLHFAPTLLIAGLLFWMSRRAAGGAMGGGGGGGPGGIFGIGKSRAKMFNQETDVKTKFKNVAGMDEAKEEIMEFVNFLKNPEKYEKLGAKIPRGAILSGPPGTGKTLLAKATAGEAKVPFLSVSGSEFVEMFVGVGPSRVRDMFANAKKHAPCIIFIDEIDAIGKSRGKGGNFGGNDERESTLNELLVQMDGFGTEEHVVVLAGTNRPDVLDAALMRPGRFDRHIAIDRPDISGRKDIFLVHLKPLTLHSSTDRDLLAEKLSTLTPGFSGADVANVCNEAALIAARGGAESIEEHHFEQAIERVIAGLERKSRVLSPEEKKTVAYHEAGHAVCGWFLEHADPLLKVSIIPRGVGALGYAQYLPKERYLFSTEQLLDRMCMTLGGRVSEEIFFTTITTGAQDDLSKITRMAFEICASYGMNKELGPVSYRTEQESMHKPYSERTGEMLDLEVRKMVSEAHKRTTQLLSDHRADVEKVAKLLLEKEVITREDMRNLLGPRPFSHADEADQYLDKKGMLKRKGESSAPPPPPEDLPTPGLAASKVEDPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHS0</accession>
    <name>W3VHS0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHS0"/>
    <dbReference type="HOGENOM" id="CLU_100590_2_1_1"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16077" checksum="4BF35884277740F7" modified="2014-03-19" version="1">MVVRLRLSRKGTRNNPFYHLVAINDSKPRDARPIEKLGEYDPIPRPVTAARLPNPSLGPAPGYGAVMTTGIAQQQAEPTLQKRLEWNENRIKHWLQLGAQPSKPVARLLDRAGLIPEGVHYKGIYRPPPAELQFQTDKNSNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHW5</accession>
    <name>W3VHW5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PaG_05080</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000556_0_1_1"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1532"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1235"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2014"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1235"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="2025"/>
            <end position="2039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETS61130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2305" mass="260140" checksum="C0CAE09CA26E6F0D" modified="2014-03-19" version="1">MPSTFGLTSRGSNVRSRGTFRKRGGGPRSGSFKSATEKAIADAAAQLVKGVEDGTAVEERFQEVKVRDDIDEKLGFHRLEQGETRQAWLVNMHPTLIRDPDHPTGKSGVDFYFIEDDASMFKATVLYQPYFLVGCRPNSESSVEEWLRRRFEGLIQSIQRERKEDLKLPNHLMGHKRLYLRLTFLNVQDLLSVRKELLPLAKAAQKKLSAVDTYADVLSAASAAAAGASIEIEMDANGESSGLIGEDGWTGGRKRAAASALDPAECLVDIREYDIPYYLRVAIDQDIRVGLWYDVSFKDGVVSLDMVPSRVKRADPVVMAFDIETTKQPLKFPDAETDAIMMISYMIDGQGFLITNREIVSEDIEDFEYTPKDEYEGPFIIFNEPDELALLQRFFSHFREASPTVVATYNGDSFDFPFIDARARAHAINMMDEIGFAKDSDNEYKSRACSHLDCFRWVQRDSYLPQGSQGLKAVTVAKLGYDPMELDPELMTPYAIEQPQTLAQYSVSDAVATYYLYMKYVHPFIFSLCNIIPLNPDEVLRKGSGTLCETLLMVQAYKGNIVMPNRHEDPVGNTYRGHLLESETYVGGHVEALEAGVFRSDIETDFRVDPAAIQQLIDDLDAALQFSIREEGKLALDDIENYEEVKAEIRTMLEVMRDDPNRKDCPLIYHLDVAAMYPNIMLSYRLQPDSMVSEAMCATCDYNRPGMKCDKRMDWAWRGEYFPAKRDEVNMIRNALASETFPPRFPNQPRRTFEDLEVSERTALLHKRLGDYSRKVYRKTHETKTVIREAVICQRENPFYINTVRDFRDRRYEYKGLHKTWKKNLDKADSLNDTMEAKKMIVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGITCLTGASIIQMAKELVERIGRPLELDTDGIWCMLPGVFPENFNFKVKGGKKFGISYPCTMLNHLVHEKFTNHQYHELVDKKTGRYEVRSENSIFFELDGPYKAMILPSSKEEDKLLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKDFQKQIFEKFLLGTTLDECYAAVAKVANQWLDVLYSKGSTLHDEELIDLIAENKSMSKTLQEYGSQKSTAITTAKRLAEFLGAQMIKDKGLACKFIISAKPFGAPVTERAVPVALFNAEPSVKQHYLKKFLRDNSITDFDIRNILDWNYYIERFGGVIQKLITIPAAMQKVSNPVPRVRHPDWLHKRVAAREDKFKQRKLTDVFRPAAKPSAIEASSASKPAAAAEPPKEVEPEIEEIAPDMNVDYPGWVAVMKKKWRKQRLQRAKERKARAAGASVFGSSSLGKGTVGSLFSQRSANMATAVWDVVQICPSSRPGEYRMWISIDQHLQALKLKVPRQFYVNFKSNPGNEVFLPGVYEAERLVKTLPRDAPCRHLYRITVDEDVYQEQEAHFSNLIHHPNVEGVYEKQLPLDVRALIQLGSSCVYGRNGPSQKLSRALDMGFRLQDLSPPTSVDISPSHSYLSGGAGIRYFYLYHAHRDGRHVLSVFSPEGDVKVHIVDSAGLRQVPNLETMYADRVAHMRKRGTLAEVKGVFEYSDTMRVDVRIHTSASRAFKALAKDLTTLRTAKQGSALLAMCTSKDQTYYETHVPSVAEFPIIKIAAAALEDELPALGWQLYSARRMFQCYLRAASWVRGWIDLAGHFDLPLCNLEKDFTIFGADIDFARRLVKQDMVLWWSPHSQPDLGGREQDIHAQSRWDEQESLELSHPGAYATVCLEVGLVDLAVDAVLQSGTVNDMEGSSSGVAFEGASHNLDEYSRGTVESSTILGDSVLTSAVFSAVKGMVKAWFMTKRRGRSQFSSLLSDNFWRWASSDASAMFEPALQRFLFGLMKKTLLQLLAEFKRLGASIVYASFNRLFLLTTKPSAANAMAYSRYLLSAVTSRELFKHVQLDIIHYWEYLLWMDTANFGGVIADVDSLVAPTEEAEAEAARTTKSGMPTFNVEMNWNIQTFLPLAVQDKFSIAVGSFIFSMYEHKQQAAVAGDLDRTPLRAVAEPNTPANGEASKDDAEDGGKDRDEVVGSAAAAVAKFSTDLINHTMTRKMLKQLASLKTAMQTSSDEINAAVARDEDEEYVDMLTAEHKRAWAFPVLPGSWLAMSNPLLEFIKTTTAVLALSRENAIEVQILKRNLLDMINVREFAPEAEFRNPCEPFKLPLVICAFCNDDRTLDLCRDPDLMPNPNAVAQTPKWKCAKCAFPYSVAQLEMRLVNIATSYLESFHLQDLRCNKCGALKSTNLQPHCECSGSFGLMVTRKETLKKLRSLHTIAGFHSLHTVQAAVDHIIAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHX0</accession>
    <name>W3VHX0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHX0"/>
    <dbReference type="HOGENOM" id="CLU_769807_0_0_1"/>
    <dbReference type="OrthoDB" id="2548520at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39726" checksum="8E9AA3DBC82CBEDD" modified="2014-03-19" version="1">MLNRSFSTSAARACVLGDQRVASRVPRLATKPLSAAAYTSAGVHGHARVQSHANASETYASRRSVSEAFSLLAGSKVSAHTGLRGRHASTWAKASPAHVRTLTTTSARNDLKQDAKDKLVEEGKKFAREKVDEKLSGEEVKQQAKNASSSLSKILFGALAVAGAAYMIMGGTAHAEEAPKSKDQGESGPRYSKDKVSLLCLVGPSLSGKSTQAKRLLKRFSSEIDDIVQPKSLDDLNAILSSRTKGNKRVSLILDNFPSTLEDAQRIEAEIVPIFCFSFYDLPLKDFELRLPKSLSEEDRQKRIDEFNKYSKRLEPLIHKYRDQGNIYEISADWDSADEVWEQVEAKTEQILELRERGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHX3</accession>
    <name>W3VHX3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHX3"/>
    <dbReference type="HOGENOM" id="CLU_030746_0_0_1"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="84"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="526" mass="57237" checksum="1195883389753899" modified="2014-03-19" version="1">MSTAKLPRGEFRNPHPDPNTPAAGKVVEALLSTVQDAHRRFADPTPDDYALARLSLDELQTRLIERTLTMPHLVEARIRLTVRASLATHCLTAFPYTDALEHAQRYQQLLDTSSTPSTLLEQYPLFGLVFSVKDCIHVQGFATTLGCSSRAAPVEPHTAEIVHKLRTLGGIMIAKTTAPQLMMHNTTHSPLWGTTRSPISSTEAEEDEFQVGGSSGGEACIVKMGGSQLGVGTDMGGSVRQPACLAELVGFKFVATPAGFRWHLPEDFMTGLPHTTVPATAPGLLARDMSTVRRAVDALEGSQASPAAWPRILHTSQYGSPEVSALIAHLVGALGDEGVQCDELGEVDAREWETAWMEHATQHGFAAARQMLATDPLIARTMFDESRLSGSSWPPHPTRLAELKQSLHARVGTDMLLTPTYILGGPVRSAAFAQLDSRHAEVWCQIMNLLDWPAVSIPLSNLRRHTRTALIHRDDEWSHFSPGMLAPDPIEGGEARLPVLSIQLVAPPGQHQALLDFAQRIAQIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHX5</accession>
    <name>W3VHX5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHX5"/>
    <dbReference type="HOGENOM" id="CLU_330443_0_0_1"/>
    <dbReference type="OrthoDB" id="2555515at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="751"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="836" mass="89177" checksum="5BAC87763DA15EDA" modified="2014-03-19" version="1">MAAGIFASLFAGSAPSDSPPPQHHGSASVEHPAPAPKSDSDSDIVMDSHTVNASVNNEAQEVADVDMQLSSPPSSAPPSAPTTPQHPPSRPIPPPARTTATTQRASRRRTMPARLSQVSSLLAGSMLEEELLMLDSAPSPSSSAFPHNGPPAPIPSSGAGAPVLDRPASRSHVANPISIIVLTSDAKLIESAIYPYAPTQSAASSPHPTSIKREAPPTDLSSSTPPANQPAASASSSIVSTLAIKRQQLIETPDFKPRDDTLYMPKTRGLRSEAAEDTSDAAYERRHRKPETAEKKQRKAEVDRLARDRQKLLARIDQIKNADARMLQPIVIARDQVRAEASAETQEHKHNSSPSRKPLHDRVEDLRRELLADAHDTLKRYDLLLSTTDHAKPASPAVPILPTKAEPMAGTSTSASNEDASTRSESPRLKIRIKRGQATWDTSESPNDTSKRSPLALSKPDASRRVSSRQPKHRVDSLPTPLTAAAVEEAQDKRRKRRRLSSSHLDDKQRSQTEASMSRRRSSPDTVPQQDSGPTSSARTSGRPQRAAAAAAAVASARQRQNAERSFSDLEYDEDEDGEVESVLDLADRSSTATPRKLSTRRNSLSLRRSPVKPREHRSASESSTASSVSSFASSIGYLGPTIPDTGSLKVSSSLSEIHAADPDATLGPAASSSPSRLDAGVEVAEASVDSKEGLEEDPDATDSDSDREIAKRDRGRGFAGALTESEAESILAAFLGTTPGGRSGQGGPAPNGAATSVSVKTSAPVPAPAAVSTPRPPQSAAQSTRRSTRRETTQSFGEKLPDVLTKAAQFDFAVMQYLRSIDRPRPASRLQPKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI29</accession>
    <name>W3VI29_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI29"/>
    <dbReference type="HOGENOM" id="CLU_009455_0_0_1"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="187"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="796" mass="90208" checksum="B7D3C9E1EF354CF6" modified="2014-03-19" version="1">MASLQQSPPAAAMSNMAEASGSGRDRSGMMNKRLTAASLSNRNTNRYSVTALYSMAAEQDVEVEDDLARAQKRLRELKGRISAQSKKNFVLERDVRYLDSRIALLIANRMALDEQSEVASTLEETDSSAVATALDDRKMQQYGNLFFLLQSEPRHIAALCRLVSLAEIDTLLQTVMFTLYGNQYESREEHLLLTMFQSVLSAQFETATEFGSLLRANTPVSRMMTTYTRRGPGQSYLKSVLAERINSLIEHKDLNLEINPLKVYEQMINQIEEDTGSLPPNLPRGVPAEVAAENADVQAIIAPRLTMLMEIANSFLLTIINSIDEVPYGIRWICKQIRSLTKRKYPDATEFAICSLIGGFFFLRFINPAIVTPQAYMLVDGPPAKHPRRTLTLIAKMLQNLANKPSYAKEQYMMSLNPFVENNKTRMNAFLNALCDVGDFYETLEMDQYMALSKKDLQIQITLNELYNTHSLVAQHLDILAPNDKHHLRILIDELGASPGQVPRKENRTLDLPLFSRWETPIQDLTTAFMSENNVTQNDILYMETKSIFVQLLRSIPTLAEKRPINLPQIAERAATTKDATLVRKGIKVKEMLRELEELKVVDRRDGYSLMTDEVATELTHLGNMREKVMQEMRSLEAVYKTICEHNNYMRSQLDTYKSYLQNVRMTSGSAKDKNAGGVGVISVGGKEKKAPKTQALGPYRFTHAQMEKDGIIVESNVPENRRANIFFNITSPSPGTFIIALHYKGREKAILEMDLKLDDLLEKQKDDVQLLDLEYVQLNVSKILQLLNKTFTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI36</accession>
    <name>W3VI36_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI36"/>
    <dbReference type="HOGENOM" id="CLU_1993586_0_0_1"/>
    <dbReference type="OrthoDB" id="10324562at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="125" mass="13368" checksum="7DB4270FA4B53DA1" modified="2014-03-19" version="1">MNEGACSQGPKHSRRTRNDAEDAAAGPAEESDSRLPKSEGGAEVLGKTTSYADTLCVTQLHSGDVHVAKKSRHGHVRLRMSERAYARMQQCGPGTSGGQARQARLESNAKRGTAEEEADETSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIA2</accession>
    <name>W3VIA2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIA2"/>
    <dbReference type="HOGENOM" id="CLU_023194_7_2_1"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="156"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="365" mass="40510" checksum="C8F8BD3997DECCC2" modified="2014-03-19" version="1">MSSPYICKWGILATGWIAETFAKDLLTDPSTRSVSDVEHRIVAVASSTSASRASEFLTKIGAPHESAKTYGSYEELVADEDVDIIYVATPHSHHYANTLLALRAGKHVCCEKPFTINAAQTEHLIRVARENKRFLMEAVWTRFFPVVKEIQRLVHEEKALGSVKRVYSDFGMQFKPDPKHRLFNPELGGGALLDLGIYALTWQMILLYADPENNKTAPEVTSSVIKSKLTGVDEFTTMILNFNATGAQGVATTNMTVRSAGNVVLVQGDKADLTVPWAPYRPESFTIHEKDAEGVYTGKNETRKFDIPGHGMFWEADACARALRDGKLEEPTCSLAESTLTMKIMDQVRYDAGCTYPDHIEAVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VID3</accession>
    <name>W3VID3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VID3"/>
    <dbReference type="HOGENOM" id="CLU_263325_0_0_1"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="630"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="886"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1062" mass="112816" checksum="9FD7B488FF142433" modified="2014-03-19" version="1">MGPSHTNPPTPSRAAAARKSTAGDPPDRRNQSPASNDRARHQPPRHVASPPPAPYSNFPPGYVHLPPTMTGPPHPPSGRGSGPAYPAYGAQGSADTHAYAVAPYPSGGHPVEPRHFARPPSRTQSQSSGSGSGASPLHEIVPAPHYAPHYSPSYSTVSSNPSAGHSGRTRWAWVPIEVPHTHLPDDAHMQYPPYHGNYYPTSTGSAASSTSSSHQPYPPAFGEGAGPMAASYGVQVPPNYPTSYPYPVHPNHYASAHQHSSHRHGVTPGRGSWSGLNQHGSQHPGANREGLSPSGGGGSRRQTGPPSRSVHGAGRPTSNSSGNQSSSPMRGPAGLPRRPSSTLAPEAEDVAAESDVSPQALGVAAAPLQSVTADTEVSPSATGTYVDVEGDLDAAGTDRVPGRGLRPHYHPQQGPRSDFVLWCGNVPQDATVEELWEVFSRLTPSEYERWLDSPEGKEHRSAAAEEDTDIDGHGVLSIFIISRSNCAFVNYASTAHLDRAVLYFNGKQVRPHDARCPKLVCRVRKKDDEAQAGVAGQRGRGIHVAWLKEKRELERALAASNTPTAEPSAHLPPTVPSAEPPSPLSPMSPPGRDSAAVAAGLASAGSYSSSGSASYTSTNSSLFRHPAFRHRFFILKSLRADDLERSIETGYWATQPHNEAVLDQAYRNSETVYLVFGVNQTGQFYGYAKMAGPIHTHTADATSKEEEQRRISLSSVRSAASASAQAAAASESVGDVSGESGVTSASDPSSKRPHPVLDKHDIQVARGLFGNLSIDGAGEASQAVPMTSPLPITPLLEEAGVRNATMPQRSDTITPRTSAFAQSSTWPYSSSRVGSDGADSAERPKLTTTLSAEAPAMTAEPDEYGVRRIDMETESTQTTSSQSDQPSLGPSDSASWSSADPRMAEQIALRAVIHNLRLDEMESRGKAERLESQLRHGSNETEATVTAAGSERGAPESNERTPPRQSSSDSWGKPFRVEWICTEPLPFQRVKKLRNPWRDNRQVKVSRDGTELEPGVGRQLLEEWNRLPPASSLAVASDRAASSSHTPAAGASAAAVASDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIE6</accession>
    <name>W3VIE6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoglucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 8 (cellulase D) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIE6"/>
    <dbReference type="HOGENOM" id="CLU_880212_0_0_1"/>
    <dbReference type="OrthoDB" id="2541080at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002037">
        <property type="entry name" value="Glyco_hydro_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01270">
        <property type="entry name" value="Glyco_hydro_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00735">
        <property type="entry name" value="GLHYDRLASE8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40366" checksum="6DA09DBB2F710452" modified="2014-03-19" version="1">MEAKYVAWRDTYLRSCGAGVYCYYNARGDNGNAITCSEAHGYAMLISALHRNRADFDGLLTFLLNFRNERGLMCWQIRSPHQPSAGRVEPFVEEDGKTSATDGDIDIASSLYLAARIFGEERYRVEADRIASAVLQYTIHPELGTPLLGDWANRDSAEGRRLYDATRTSDFILSAFALFSRQHSDATQRQKWQWVLQRTKQTALSCGGATGFLPDFLEHKSGDGAGQWQPAKGKLLESEHDGDLNWNACRTPWRLAHYLAVTGDTSILPLLQHAHHSARSIPAFSFPNIPAGVQLNASHGVKALVDYSDKSFIAPVGYMCHVLGDADGHRQCISALESQGESYFGDTIDLLIAEQATHAHEWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIM9</accession>
    <name>W3VIM9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIM9"/>
    <dbReference type="HOGENOM" id="CLU_087075_0_0_1"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000012">
        <property type="entry name" value="Related to 50S ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31201" checksum="1E9B138B3D86013E" modified="2014-03-19" version="1">MSAQRSSKPLTALFKSLRLGANPSTTSASPIASSSRCFSSSHIPRAASKAAVAAKTPQRCKSTLHCRGMLVHTPADPILRTLCSASTAATYPFSSAALIPEVPEFISTKQGVKPPPQAKSVLSGVMPRVHSELRARYDPGNRLTKLFDRHSRERIPPGSVLIVESWTSPLKTNFSSFSGVLIAVRRRGVSTSFVLRNLVQKLGVEMRFNLYSPLLKDVRVIQKAEAGKNDKSGKLRRTRRAKLYYLRNDDRRLAGIGNVIKQQRLLEEKRAQEISKRRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ91</accession>
    <name>W3VJ91_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ91"/>
    <dbReference type="HOGENOM" id="CLU_446269_0_0_1"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="605" mass="64066" checksum="7B57E3D1429D55A8" modified="2014-03-19" version="1">MSSPIFGSLPSSGATATDARHRSSSFSAPRLDLVLRPSLGLGPFKLGHSLWHVLNYLRSQQSLFPHINIVYDETAPRLSPIVVTIQPSLHLIFHATTQRLILITLENLDATASTGSRNGSPSAPAPASPSGEPSHRPVNLFYNGKLIYASGSARSQHVVLNRSTLHQILGPTYPGRSESSHVASESLVALAHGRKDAQHLQSRTEFLLTYPGLAFCFTLKSDAPKAAEVDKLQPVSSIHVFSGSDPDNPLDVLVAPSPDQGSSDAGAPGRLHKPGTLSPTAALGDYAQLNNERDRAALDVEAIYVGAPVLLQADVTPGKSVALHFAKTGASRTASPLPGGGGTGAAATEAPVGNVVELMLGVTTPQDALCDLGQPQRIFYKEDDRMRIHGGSTHAGADGQTRGAAAGAREGSENSTATDESLAASHELDDSAFFYNYFDLGIDLLFSKQTMRMPSGAEVYGAAALGQARLEKVVCHTNVPGDALFQRYNRCPWRVVRDVAKKTANTKSEAAFSFEDHFDSTLSKGQDDRGMELDRGTSAELRGSGANQRRSVPALHAKSSALDGSPEREGATGELLIDLSTRLVGRDGMVIEVAKDGSMVGVVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJA3</accession>
    <name>W3VJA3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237111_0_0_1"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="9">
        <location>
            <begin position="122"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1700" mass="185037" checksum="EFA946F5459CB4E5" modified="2014-03-19" version="1">MPPPTASARGRVKHAADSQQLPEPYQQERPSWRPPLHPAAPQRDVPDLFTTKPNQPEDDMSQLAVRKGFTARNYVRNEALSAHDSIYSRLNSPAILRSLSSWMDEVAQRRHELDRAHVAASQYKPPSRVTLNDAKLANYVKDLADPTVPLARLSRNVPHGFRGEKLFEMLWAGGALPATIPAASSSSTTAAAAAAAAAARRSVEISRAVWFIRALGAAELSSLRNKSAATIVPEITSNLCTWMAKQVAELNIAYAAEASSSTAAASPAPASPSTHVPRTPGSAAASAALSRSVAAAHFARTPSNLHAASSPSPLPAKEVCTVLQNHIDQERWIAKWSYSLSLARHLHAQHLLDRSILVRWIVDAFAASNLVQLPLLVELVQEVILLILRRRCFARPFLAALLAQITALDARFDRAAGGAALRNKLLLLFRIVCESSPDTLTSPRLWCENAASLVRLLNELKGEAELDPSAHVPPNLADFVELNIRPRVDRLLLQSSSATPTDTQPDSPSASHSQQHHLDIHALDSFDMKTIDRVFLQTPAAGKAAAKLHRDDASWTTRIETILTWACTERRRGVARQYLAATLIEKIRFGVGWEESSEETDKISLPAFDLEHPLKKTRKINVEPMLIKWLGDVEAALNLPDDALTADPHAALLATTNVSSLVVLIGEVARRGVFSYTKYLQRLIARGMTTTSTPSATTDPTAAVTVGAPKDAPMSRDSLHLRVLRSLPLYDQPASVFQQRRQAIYGERTKETYEDAAQRRALRQLQSLLPFAFASEDAGAMVDAPSTETTVEPHDLQHALSRLWSASRFVRCRIFRSELLPAVSSRIDVLSGEELSLVSAILVMGDDFECLAQLLATLLLRPLSDSLARPAFNMVIEFSLVWRSMDIMGTLNQLVRQQLNHSSSVRNDRQAVMASTTLLRLRTLIEGLPSRMHVAPHDAHAEHDAIQAHVQALRPNVVALLLRLTQRTEHSDRASDKGATTPIEGSEILTPFRSLFLQPDGTSDEITERAIVQSVLQLSDPAVIDAAVRLIDQLYLEASLEIDERHARWLGDLAQSMEHGGVSHDAFRALLGLLSRLVAHGTLNLQLMVDTFLLPYLLTGVTQLTDPATRNQDSMLHVTAVVACLRQMFSGSLGDEGDAGGNSTYEDQRAFGAQTVLLFARVNLPSLVKMATSLICASGETSSLSAGDKAPVEAFWRALLTSERMQLAFRQEARVCMLTVRDTCKAMWGCNAAKVMDAAMACLDSTSLLLGDLGSIDAGAVRARLNEWDTPVVANELVEIFERLQLVEPSFQSRADTKTKALAAGIFDDLFLRLPHIGAQFMRDCRSPALVSRFVDIGVKILADRIKAQSGEDAAAEAAVGEVLDSLLRMGCQQEGFAFNATDADSCGHVLLHVIHTLEAASSQAETCSSLSAAVSSALHDGVTMRLLHLVLRFGCLWNGAAKAAAPRLIQVLLRLALHAGTRIEGGGAFTLLVDTLSFVLDEVPAALVGVGEMEAQLQRAEVATPERMQRLQALSYVLDSGPGRHAWMVAPNARAALGRGWFAPGPLNPWECAEYLDPPAPAQTSSAAHSITSGQGARFGWREKLRLNTAVAPSLLALRVTRDVVPHYASPSHVSSPTDQDEGGGMPMFVESERTYGARTAGEPLFARDLRRGVLPLPITHAKVGAARVDVIDLTFDDDDAAPVVRAEVPRKRRMSKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJC4</accession>
    <name>W3VJC4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJC4"/>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_1"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000157">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000071">
        <property type="entry name" value="Cell division cycle-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001474">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="283"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="631"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="863" mass="91411" checksum="51763EF00A64CC5B" modified="2014-03-19" version="1">MSGAEPASTSFVGAPHRVRIVGSSAAASSSSRNKLLLPPDSIRTLRLQTGDAAIILAEGSEDAGFLVGSVWPSFTLEAGTVRLPTAAHIPASLQAGQRAVVLPLQTAHSAMPLKRPPTAVRLSLTPAPAAPAASDPHHDPSKLGKSDRQMLTVHAKECLADLECIHLGQVVSLGFHGQVYSFAISSVMDIDGQNGCEVSLSDSTPRSTATSTTTRVSTITRATAVSIVAAGKESTDSANAASISKEDPYSKLGGLDRQIAEIKTLIEMPLMSPEIFVQYGLKPPKGVLLYGPPGTGKTSLARAVAAATGSSYLTINGPELSSAFHGETESKLRDIFKEARRKSPCIIIIDEIDALAPRREGGSGDGSNADGAGEVERRVVAQLLTLLDGMEDGGGEDSDDDHIDEEQQGGAASPSESGQKIASGVGKPPARVVILAATNRPNAIDPALRRYGRLDREIEIGVPDKHARQDILRTLVQPVPNNLTAEQVNDLAGRTHGFVGADLSALVREAGMRAVRRTFARQQSMSDQLDVQLRSMSLSQASPSAPAVQGHTDRVTAADLLAALSVVRPSAMREIFLEPPKVYWSDIAGSATPSSGGSGALSTKSVQAQVRELVEWPIKHAASFARLGVSPPRGVLLYGPPGCSKTLIARALATESGLNFLAVKGPELYSKYVGESERAIRETFKKARAAAPSIVFFDEIDALSSSRDGEQSGGDALNSRIIATLLNEMDGIEAMSDVIVVGATNRPQSLDPALLRPGRLDRLVYVGPPDHNARMQILRTRMAKMAVAEDAVDLDKLAQMTEGCSGAEVVSVCQEAGLLAMDEDINCDKIQQQHFESAASSVKRRITSLMIRQYETWRDTLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJG9</accession>
    <name>W3VJG9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_04188</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJG9"/>
    <dbReference type="HOGENOM" id="CLU_003041_5_1_1"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="178"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="459"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="819"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="878"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1059"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1073"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1128"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS61689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1155" mass="125099" checksum="FD6BBC9C3F165277" modified="2014-03-19" version="1">MAKTIDFLASDGEDDVAFAPKPSKQKRARTTPSSNTAKPSSKRTRANNDDSDDDDGFDITNSLVSNTLPASAASSSSRPVKARPSRAVDHNMQQDDDDDLDEAQFIASVMQQANVKAGVEVAKKALSGKNKGKNKLGSGVVTGGGSFQSMGLHPSLLRSLLIRGFTTPTPIQRQAIPAVMAQPPRDVVGMARTGSGKTLAYLIPLINRLNGRHSRTFGIKSLIFCPSRELAVQILRVGKEIARGWKADPGEGQDSRGEAIRWAMIVGGESLDEQFAIMSNNPDVVIATPGRMLHLTVEMNLDLKSVEYVVFDEADRLFEMGFAEQLEEMLLRLPPTRQTLLFSATLPKKLVEFAKAGLQANPKLVRLDADSKISADLRMAFFSVKPSEKEAALLLLLRDVIGVPLGEQAAPDLEEEDQFNEDNSDDAGEQLKRQAWSNQKHHFKGKTKGKGKDLAAKRKRGGALELLPHQTIIFCATKHHVEYLLLLLTTTGYACSHIYSSLDQATRGIQMSRFRRGQTSLLIVTDVAARGIDLPVLEHVVNYDFPPQPRTFVHRVGRTARAGRNGWAWSMCTNAELPYLCDLQLFLARPLVSSHTAVAALADGQEIGDADSLGLHDSLVLGTFPREALDLETEFISSSLTNTSSSTVHDFPALKQVAERAQQKYEKSITKAAQESHRRAKEMIKLGSIEQINIRTANGVEGEVPEWTLAGSPLEETAVHDVIKRPGVYGLNGAKMSESARSVLGAAAAQGATGKAAGKEAEEAAARAALLAKVNAFRPQETVFEIGIRGDATPLGALMRSRRQTMDVKTKRAEALEARKRAMEGGSEDAQDDEAKGAASKKSKNKKAAADDEAGAGDATVDLEQADEADILAAFDTGPSSVNKASVKVSARDESDSQAESDSDDEGRPAKRTRSAAPGKKTKAAGSYRDPNFYLSYEQEGSRDERGYSLGNPRSGIDSFVQQASAASFDLAGDDATMGTQSQRPNVTRWDSKKKKFIQGAVGADNKKMIRTESGVRLPASFRSGRFEDWKREKRVDMPKTGELESNSNSAVDSVMGLKKFRHNKVVPPKAEAFGKGRPGQDKRQAARDEVKSARQIQKEREIKDKRREKNARPSRKDAKGRPRASRGGRGGGRGGSRGGGRGGGRGGGRGGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJI0</accession>
    <name>W3VJI0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.131</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glycolipid 2-alpha-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_04198</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJI0"/>
    <dbReference type="HOGENOM" id="CLU_355695_0_0_1"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="17">
        <location>
            <begin position="38"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS61699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="799" mass="88740" checksum="D07804F163C1DE03" modified="2014-03-19" version="1">MDRLLNVQTALSLSYVCAMVLAAHLAGRALLASTATRKTRLIFLWLAFDAICHLTLEGSFLYLSVRGRTVNASKSFFGFLWQEYAAADARWGTADPTLVSMEFLTVLVAGPMAGYCAWLLAKDDPTYYYWVTVLSAGEIYGGWMTFAPEWLAGSAQLDTSNWLLLWLYLVFMNVVWVALPLWLMLDSYLYIAGRLRSEPARVTRSRSTKQQRTMVDALTSARGLSGSAYTLLLVGVFLYMMPASVRASSTPQPDAGKPAYDPAATTVVYERTDSLGATLKSVLVPIFLPLFLILFSVTVGAVQVADKALRRVHRTNRTRRRKLLGELGIDEKAELAADQLARTIIGFFHPYCNAGGGGERVLYEAAALHLARDPRAVVVIYTGDFPAASKEQILAKASTRFGISLDAGRVAMVGLKRRWMVEEGAWKSWTLLGQSYGSVWLAFEALSQLVPDVYVDTMGYAFSYVALKLIDRKVRTGAYVHYPIISTDMLRRVQNRQAGHTNDAATANSKLRSRVKLVYYRVFARLYSWALRHADALVANGSWTQAHLKTLLGAKHDVHLVYPPCDTEELTKFALEPRAEPRTIVSLAQFRPEKEHPTQLRVLKALYDLQPQLFSGDGAVKLVMMGSSRNEADEARIEMLRGLAKQLRIDAHVQFVVNADYPTIVSHLARAGVGLSTMKDEHFGINVVEFMAAGLLTLSHRSAGPWLDIATPSVNLPAQQGAVEKSEGVGWHARDVDEYAETLAQIMHMLDADSLQVQRIRANARARAQTMFGRKAFEDAWLQHLWSPLTAGKDKSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK52</accession>
    <name>W3VK52_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK52"/>
    <dbReference type="HOGENOM" id="CLU_007483_0_0_1"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="814"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="647"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1105"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1108"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1128"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1215" mass="129239" checksum="45A0364378112AFE" modified="2014-03-19" version="1">MPLEQIRPVAGLNSSESLRRASYFGEASTSYTSQSQSRDDHGSDSDRDHADHDGDDEDADLRRYSTSSRKSESMSLSKLGGVGGVTRSGSWGRNSLSDESHSARPHRDESRQSLFRPLRSSLAQYREESDEEEGSHAHTTAQSSGLPSAFEVGGAADRRSSDGDHGKPAATLRCDPQPDRATSSGPPASSRTSTASSAAAFSLRSLSNRNSTGSVSSLASSVVSRGESDRLTPATPTESPIALDPSLSAKSPAESALTSSSSSTSLTAPASPTRTELADPSLPVPSNAPHDDEAQRTAPSPPVDQMATKEHQLDTHAAAFTSDDATSASPDQKSYAREHDSAANNPATFLTSQLSPPPDKMNTRAESLSPASCLQPSAEELLSTSSTGIYSPLIPRRHSGMIMLRSRSQLALHSGLAMTFANSGGGRAAARERARKQTGWENAPFSVLEAQRHARSFAYSQPASPGASTTTIAWDPSASPALLQPAANVTEGGLASSPQLATRPLGRTLASPELSPSTQLPVDSSASTQRPAPPLRQKSEHSLSRAALLRLDTMLGCPVNEPADPALPSSADAASSSVSVGPRMQPVRSPSGSVILGSSSLLRTPTTEEWSRYLESQGVGLAGRRSRTGTNLSSGSSAQRINRMAMSGIQSPSKADIESGVAGGAEYGDDSDLDSDDSDDHDLGVEVLEKLKQLGLSRAASRAGSVFGDELASLHEEDEDNLSPVSPQIDKVQAVEDLTPLTPLASGAKTLPPQASPGLLYDGSPGTPQPAIERGATMRLPRSKRPTMSMSGDLQPAGQLYPSDYKGQKGITDFEIVSDVGRGAYGLVKKARKKGPDGRPQGKEVVIKYIIKSRILADCWRRHRVLGPIPVEIHVMDQLRRIAYVPPSKPRPWAPQRPKTLEEYRARKRAEAEGEQVAVADAASADGALSHPNICKMLDFFEDHEFYYLVMPCFGRGQDLFDFVESAPDGLAASQCRSIFGQVADALWFLHANNIVHRDIKDENVVLDGEGNAQLIDFGSAAHVRPGKLFDTFSGTLDYAAAEILQGEKYSGQAQDVWALGVVGFVLLCGECPFWNGEEAIQGLEDGTRAAQTLKERCLIARVTPADADSEPREEEGELAPLDPAWSRGKDKEGAEPDGGGRVDDFVDLISRCLELDVDARPSAEQICQHRFLAGHAGWTGRRGWQRLKAPLVASCSVPAEVKVSAAPTILAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK61</accession>
    <name>W3VK61_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK61"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="103"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="216"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="641" mass="70874" checksum="232DD745440217D8" modified="2014-03-19" version="1">MSAQPNYDACDTCLDIVAEHRRTLQLPPSTVCTDAKLTEWRERANAVLEPPSSDVPGPALALLVQNEPTKTVWSSELDALLDGRDASAIAELTTSGKVSVLAVTQHFVKKASVVHQATNCLAQMLADDALQRAQQLDEKRSRFQAEGRLHELGALFGVPMSMKGHIPYNRFGNQRGFVFDVLPDPTSHPLVKRNLTQEQLELLKDTQGGYVSERPNAHLVELLLDADAVIICKTTMPQGVMHLDTTSNLYGQTLNPLNLALSPGGSSGGESAIVAGGGVALGVGSDIGGSIRQPCAVTGLYGLRPTTQRIPYGGVRSTMPGAEGVGSSIGPMAKSLRDLERFMASVLNDKTRPWEREHFTLPMPWRKVDSLFAGGKKTLVVGVMMEDGVVRPTTPVRRALGHWVDKLARAKGVRVELRRWEPRDLHRRAWDMIRSLYFMESGKYFHLLSRATGEPLLPLTQFILAEPFVRSAEADLAANTAGEARKQDEMSASEVMASVRMREAFRAEYLRAWNELGLDCLLCPATANVAPRPSTVKYWNYTSVFNLVDYPGVVFPSGIVADSALDREFEKQPPKAVDGFEYDTRMEGEWMGEFDEDNTREYEQHRDVFNGAPVGLQLIGRRYKDEELVKYAELLDHIVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKB6</accession>
    <name>W3VKB6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_04069</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKB6"/>
    <dbReference type="HOGENOM" id="CLU_026207_2_0_1"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="25"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="148"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS61955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="457" mass="50306" checksum="3E4D4198E07D00E0" modified="2014-03-19" version="1">MTRSNPIERLECVIPYAADHPFPLENLPWTVFSTSADEKPRCAVRIADSLLDLALLSAQAPHAFASGPLSDQRVHGLFSQPTLNAYLAEPRQVHRDFRSFLQHMLSSDSHVFNSDSQAVLQAALVPVEQAKLHLPIRSGDYTDFCASKYHCTATGRLMFNDPTRPLEDQWFQLPIAYHGRSSSLVVSGTNFHRPNGIFRTRPGSSDVQFGPSKRMDFELEVAFVVAGSELSPLGRPVKLDQAEDAIFGMMLMNDWSARDIQAYEMNPLGPFTGKNFATTLSPYLVELAALEPFRTPSPTAEHTPFAYLDHQGNGTTWDVRLQAFLSPAPPPTSTEQERVWTKITDTSLKHVYWTASQMVAHHTITGCNLKPADTFATGTCSGPFDESHSEASLIEACKAGRQPIPLNSAKGSTATETRCFLLDGDEVKILGHAFDPESKLHIGLGECTGQILPAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKQ9</accession>
    <name>W3VKQ9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKQ9"/>
    <dbReference type="HOGENOM" id="CLU_009808_0_0_1"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="5">
        <location>
            <begin position="358"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="4">
        <location>
            <begin position="558"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="6">
        <location>
            <begin position="810"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1093" mass="119710" checksum="D3662066D3D6D026" modified="2014-03-19" version="1">MPSDVHSSHGRPPPLVVLSGGLVSHVHTVMGFLAFFGALVTALSLHYQKVVKNHVAQYPDEWWPSVSATIGDWYPERNIFQVGIALMAGPRFALVFLSALLVSLSTPNRSPKASILLFVGVTRTLACGGWVYVTSTDDHLFHDIAMFLYLALTPPWMFITNGSLAQPSLSPGAAASDSTSKDALAAKARRMRRIACFSFFACTPFMGFFFYRHNALHIPGAYSYYAYFEWGLIIFDLLFDAASVYDLSRFEIHIVEAPKPEPSFSSSAARDTAYGPEGRRLIDGAWAQGGRHRAIASGAWSASQLGAGSDGQQSAPPKAATEEDDAVNPILVDDLESLASPTSLRAIIALISDSYLAFCFWTALTALHPMIFYFSVYNLAIGGHEALLISQVLGLGLTLAVPALRSRVRRQSSSGVATVGPVSSQAKAIGWLLSLAGQASWCVSDPLVRLVAVAFSNALLAVLLALEWGAAWETDRLPVKLGIWLVGLLASNLAKYANHSNNPAWPFMESTNGGHNALLLALALVAIAEMAVRPKYDRFPSLQRRQSSRSAFTGSKTNGSFTVAALGVGALLYALHTFLTDTGTMIAWGWTGYPVRGPMAIPHGCIILVTMAFSSLAATRWTTFGYRIALFLLQCASAALLYFAADWTSFVGAVGMALSLPPMAFPIISAAMRHDPIKVLLFGWLAANVLTFMGVLTVAYAFVPGGKVLRERTGFMLVVQLVLLGLGLANARRVDSARLRASRSQSGQRTAQVADESNVAKATRLSNASRSGSTYYICLLMALIGLVGNLVPLYRIVPSSSIAPHHAEHRLVTAGMWTVHFALDQHMRDSSRRMASIMKTLDMDLFGLVESDLHRPVFGNRDLTQYLAEELKMYTDIGPAPSKHTWGAALFSKFPIINSTHHLLPSPSGELAPAIHAVIDLYGTPTHVIVSHNGQEEDPLDRELQTTEIARILREAYPHPAIFLGYVVTKPHAERPAPYKILFEDGKMQDVEPTDFGRWCEYLGFRGLERISYVRVSRYTVTDTELQTMKLVVPKEPLDPDTNEFTRFVIAETYAEPMRYPTSLIDPDAYVYDKHIYSPYPWPIYYGRPVPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKU7</accession>
    <name>W3VKU7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKU7"/>
    <dbReference type="HOGENOM" id="CLU_715952_0_0_1"/>
    <dbReference type="OrthoDB" id="10576584at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="386" mass="41840" checksum="F0E24B87AC93101D" modified="2014-03-19" version="1">MRAISWHLPRTRGKRRLREHSKDKPPDEPESKTSDKSEPPDTNDAGVPERGSISEVAIADAVTSDDPVSSVRRGAEGDASEAQPSPEKKDKRNKNKDKHKAHSSNSGQQPAAALTASGARPFLCDGEAGPATLASPARSVAHVSTLLMHEANVDPTARASSGSARDVKKAKQLITAGLQQIDDFKETAEPGQHNWAFLGKHWPYGYMDGVEQVHRIFNIAFHALLARQIGLTGHKTIPRDFKFHRPGWVADVKTISGTDARHARDLHSGINVGNGSAEVEAGLEAGSPGSSEANGCSGCSPAPTMRESLMATFIVNIAGLARQSRKDLEKVTEAQTSFHRSFKATYLFPFADRATGPFILKRDRPSEDTLPTCHDIHVQSFRRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKX8</accession>
    <name>W3VKX8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKX8"/>
    <dbReference type="HOGENOM" id="CLU_005210_7_1_1"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="207"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="271"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="388"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="460"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="547" mass="58442" checksum="F90023CFCC522652" modified="2014-03-19" version="1">MSKSSKVELPQWGRVLVTGGIDWPTLGRKATKNGPPLSVNPDHPDLPAPHILRSVSNVRMKRIFSSHSSCHAVLLSVDGDVYIIGRNEHGQCGLPIRPVPGSSKPSGVAVWDAYMLDAATDFSPALPSGPKGHIVAAACGRSHTLLITAGGSVYSAGLNTSGQCGHPESQTVPLFTRIETGAFIKERDPVVAASCGLTFSMLLTQSGKLYTMGSSEKGQLGNGRTGEHFTSNNRLAFNTFSEPFLVKQLADKNITSIACGQQHSIALDDQGYVYVWGFGGYGRLGLGSQQDQLTPTLVPQFARENVLMRAKSIYAGPTNSAVVDGQSMFWIAGKWKTSGDGSAGQGFMTFKYLPDMMGVKVTNSGLGGVTLLCTAIEEASLQGEHGATMNICWGQNANCGELGLGEGKPRSATKPLRCETLDGIAILDIAAAQNTTFYLARNMGERYGELPRWPEVVPSQEVCMVCGREEGEGGEDNALLECEKCENPWHLHCLSPKLSEIPEGEWHCPNCQPPTAASKSNSNGKRANADSDDDEDAAPTNTKKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL50</accession>
    <name>W3VL50_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL50"/>
    <dbReference type="HOGENOM" id="CLU_016971_0_0_1"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="568"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="820"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="850" mass="88559" checksum="E0F4364A59EF35F8" modified="2014-03-19" version="1">MSYPMVFPPSTIRPLPGGTTLVSAQPAAPTAAVMSTESFDAPEGMYVCTSRFTPPPQPMIHLNPVPTTQLALSAVYPTPRVSTVSLRYPVSSKNAKGADSNAAADAVASSARAVLLEAPLASQGIDAPSSSLTGGLPPGSSGPLAGIAGIGGAGMGFAGLGESMGKLSPKPSRPKNSLKNTSSNFVNRMMTHPDLAKILAARSDSEHFTFLTNARSFFWLADTNGRTKESLARITFSASPSAHDVNHFTRAHDRLDIVIGFVTGDIIWLDPIASRYTRINKSGCITSSAVTQLRWLPGSENLIMAAHADGSVLIYDREREDSSDFSPATWDAFAGDSTASSSSAALQSAVAAASTAPSSAPMSASQTSASNASFASNSATGPSTNGLGSSITDSRPVLGSRTVTSSTHATTTTHNDAAEGAAVSSSSGSATHLSKPKSHTPAGTLSQRRQAADPSSSGQPLLLVTKPGSVPIASGLPSGAALHSREYQQAAAAAAVAAANAGSNGNGLSGKGKETSWARLNPVSHWAVAKTRITDFAFSPDYSHVALVADDGILRISDLNAERLLDTFESYFGGFHCVAWSPDGKFVLTGGQDDLVTVWAPREGRIVARCQGHTSFVSALAWDPWRWSSDDRTYRFASVGEDCKMIFWDFSSAALNRPKTHAPHGVGPRRSSVGLGSTYSLVDKHGASSMRSPGSVLNARRMSTSAGVGLGYDRTAVTDDTIRHPALPRSEVAILQPVVTVEVDGEIPVGLRFGPDKVAVVRKNAAIDIFTRPMPKRPTSVVASLIAGTDRTSWPAGARTTRWSASTPASQAALTINTNGALPTHSHQPSATTPTTPRHPTDTSQPVITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL71</accession>
    <name>W3VL71_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Choline-sulfatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL71"/>
    <dbReference type="HOGENOM" id="CLU_006332_9_1_1"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16032">
        <property type="entry name" value="choline-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000032">
        <property type="entry name" value="Choline sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017785">
        <property type="entry name" value="Choline-sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025863">
        <property type="entry name" value="Choline_sulf_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03417">
        <property type="entry name" value="chol_sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="5">
        <location>
            <begin position="502"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="65255" checksum="D302AAF5AD76F711" modified="2014-03-19" version="1">MPVQDSHAFGGAGYSNGHANGHANGANGHAVNGHANGAYTQAAASTSTGRPNILFVMADQLAAPQLRMYNENSQILTPNLDRLARDAVVLDSAYCNSPLCAPSRMALVTGQLPSKIGSYDNAASISSDLPTYAHYLRSAGYETVLAGKMHFIGDQLHGFEKRLTADIYPGDYGWAVNWDEPDRRLEWYHNASSILQAGPCVRSNQMDYDEEVLYKSNQYLFDYARRSGGASSARPFALTVSFTHPHDPYTIEEEFWNLYEGVDINMPEVEIHPDRQDPHSKRLRHVCDLDGRQFTPEQIKRAKRAYYGSVSYVDAKVGQLLATLDKCGLRDNTIIVFSGDHGDMLGERSLWYKMSYFESSVRVPLLFNYPKMFSPRRVKANVSTMDLLPTFCDIVGIPLQQQLPLDGISMLPHLLGRTGHDTVIAEYMGEGTVAPLCMIRRGPWKYITCPADPPQLFNLAHDPKELVNLASDRDALDEATRKVLDDFELEALKRWDMAKITEDVLLVQRRRRFVFSSLKQGAWTSWDYQVPNDTQNMYIRSHMDLDDLERMARYPPVDEYGNVISASDFVGPPSFTKGQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL73</accession>
    <name>W3VL73_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL73"/>
    <dbReference type="HOGENOM" id="CLU_002472_7_1_1"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="878"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1067" mass="116807" checksum="3D43731F0C97EFF4" modified="2014-03-19" version="1">MLLAAKLFSMPSAKQIKHSHQEMPSRPGSAASVASSTSSFRIPGIQALAPPASRQSTPSDPSFVLPASYVRLFTPDTDAQATSQSRTLHIPSRQNVDWLNTHSAPPPREFLERSQTPREHPQPLQVNQRLHGQGHFAASESLRQSGPTDEPLRPFTASSYHRSRLVTADGSSSNYICAVLENRGTGREVGIASLERDTGTCVITQFADTPTYVRTIHHMSLYPPSVLLVPASGVVTRNGPSSASTSRASKRIKIRDQGASEPDFEDAPTSDYRNGTSVLIRCLEELFDIQASPIPRRSWDYQEGARYLDRLLVDDIDQANEAKEIDLGLSSRDRQTAPLASQGSERPATSRPQTGLTSLDFSAKASTRAAILVAVADKFFLLSAVAALFDFFSQSLNRIFTPRSLRIQFVVPEGTILINSNTAHDLELVRNLINPSSKDCLYGLLDHCATPMGRRLLKMNILQPMKDLDAIAVRQDAVAECIRDEERFHAIRQSLKPIRDGGIDLDKLINALSCCERRVATPRSETERKVGSILSLRTLIRSLSSARAALQNASSGLLQAVQLFLDSEELDLIAEAIYQTIDDDIIHAKGGLSSRNAKLYAVRAEKSPLLDVARETYKENINDILQLCEAESQETGLSITLKMVHTGFLFQTKCERSRIKSLPERFTNITPAKTGNTVTMLTLTLKKLNARLVESMNEVLTMSDTIIDELIEDIIGKVASLYKVSEALSLLDMVVSFAIVSIANDYVRPAFGDSLDIRSARHPILDCVDVPASGSSAIFMRRRRAFVPNDIYLGAGERVCLITGPNMSGKSTFLRQIALITVLAGIGCFVPATRATLPIPDAILSLLTHEDDATQNLSTFATEMRTSAFILSVGSPHSLVILDEMGRGTSPDEGSAVATAIVEELLNDKGSTVFFATHFGELVDGFDGKDGVVCQHLHVSTVQERLDVSLVFHHKLHLGPGLDTHYSLQVAKMMRCFGDGFLQHAQQIAEAEQASYASRAREVSPDTRARRTMLRKIVRDLRRLLHESRTEAAGEGGGPEHQGESLAQKLTLLRLNAATDLASTFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL80</accession>
    <name>W3VL80_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL80"/>
    <dbReference type="HOGENOM" id="CLU_445619_0_0_1"/>
    <dbReference type="OrthoDB" id="3367070at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="612" mass="64771" checksum="3F3FD80DD47E8514" modified="2014-03-19" version="1">MKAIFANFGRRTNVDRKDASFEVASKTPLGTPSKEAPRVHAIYASLDTAASAIGDVPSTAPGSNRFHTDRLQYHSDAHTGPPNAWSARLSGSLRSASIRRKPLQAAGTNDASANLKPASRSTHAPSSYKMPHSQPLDRGADSPALLRKASTTSKRSAPKQVSSSRADRVLVSDSLDFPHPSGSDPSARSAAHLHVDVPSMSSADLAVRLDELAVANADGLLTDDEYRTLRQAVFDRMLQADKHLMSAPSDRDLSGSGLPDHVLGKPAPSPPNGSARHAHSSSDHLAVSRTGSMRGQAERPGSSIRSGQSATSSSLQHASNFLKKSVGATKMHNRSGSSSGGVEASVASDMARNGPLRRDSEGKSSQLSSGDGHSQRAMSSRTQRSSGAKSSRLSTLGRLRAGSQSRRVHAETAARELEEAFSAERTARSLRAVSLYETGASEQSAMGGIARERSPTSLRAEMAPTTLFGVEYADKSSAEIQAEIAVVLGEGNRMLDTFAALEQTLVAKHGALEAQAVREVVERVREANPQACVHRLEASAPPPSSYRQPRQAHASSSGLGGEDGGGSDEARALEAELTSNYAQRAAVVKRYQDRLAFLQSKARSAAMREGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLF6</accession>
    <name>W3VLF6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLF6"/>
    <dbReference type="HOGENOM" id="CLU_553334_0_0_1"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="313"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="493" mass="53817" checksum="05259127093ABBBE" modified="2014-03-19" version="1">MGAQSKAGIAQPERARRALQPQSAVAKRARSGWRRPDSVFAGSSSRTSINHHPPFINLYNSSLAATAGSAWSQHSEAKWHPTWHITNDQVSQRPRRPQIAAASRPTPKAVRHSSISRSVTVRPPGFTNQSRAIAKPASMTQQHEDGDEPYTQLAQAFQFARLDQIDQHTLAREQASTAPSAFAVIRLFSTTIAHAESKRGSQQHCHVTAVRLLLPFHSPLASLARLVSADARLNTMADAAPRGRGGFGRDRGGRGRRGPRRGGRRDGEKEEWVPVTSVGRLVKDGKIKSIEEIYLFSLPIKEFQIIDLLLPKLKDEVMKIMPVQKQTRAGQRTRFKAFVAVGDSDGHLGLGVKCAKEVATAIRGAIVVAKLSTIPVRRGYWGNALGEPHTVPMKVSGKTASVMCRLVPAPRGTGIVAAPASKRMLELAGIEDCYTQSAGQTATMGNFLKATFEAVSKTYAFLTPNLWRDIAPPATPYVEFASHLARTQKKSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLG1</accession>
    <name>W3VLG1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLG1"/>
    <dbReference type="HOGENOM" id="CLU_1107509_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="251" mass="26447" checksum="4A51C8E383097686" modified="2014-03-19" version="1">MHLPSHLRSTVSAQQQRMVAFDGERFGPAGPGLQKDSRWEAQSHVQRSRAVEARARAASGPAWAAHSSRPYAEDPGYQGGRQQSAHSYTSSAIHGSLTRQTNGLQRHPPGAHLGHTSPPVRTATPGSAAHPRRSELPCIRAQRATWPGTATPLPDTRPGLDALALLLLVPTPSLGPPAPRRCIASTSASLKSALSLAHPSSPTPKTGPSRPGLAATIVIIHQHSLNRLVDAPSEHPSSSPIRPPSTSTAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLU1</accession>
    <name>W3VLU1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF1692-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLU1"/>
    <dbReference type="HOGENOM" id="CLU_034705_2_1_1"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="174"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46646" checksum="D53CA8A70221FB42" modified="2014-03-19" version="1">MAELLDSLDRLPKIRQFDAFPKTQSIYTQRSSKGGVLTIISALALVFLLWTELSTYLYGERGYSFAVDSQLQSTMQINMDMTVAMKCHYLTIDVRDAVGDRLHVSDTEFKKDGTTFDIGHADRLDALPQEALDVGKTISKARKKPLYRRKPRNKKFSRQVAFHKTAHLVPDGPACRIYGSMEVKRVTGNLHITTLGHGYLSMERTDHKLMNLSHVIHEFSFGPYFPEISQPLDSSVETTDKHFTVFQYFVSAIPTLFIDARGRRLHTHQYSVTDYARPIEHGKGVPGIFIKYDIEPLQMTIRERSVSLVQFLVRLAGVVGGVWVCVGYAFRVTTRISTLATSTSDRDSPEAYAASYGYTRPGMHKSPSWIAANDAVGKLKDKWANFGADLGRTPGHRKVDSVQQRILSEEGRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM00</accession>
    <name>W3VM00_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM00"/>
    <dbReference type="HOGENOM" id="CLU_286074_0_0_1"/>
    <dbReference type="OrthoDB" id="2551619at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="969"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1041" mass="108664" checksum="5867D58B1FE2C6B7" modified="2014-03-19" version="1">MSSSIVTAAGKSLGSRHNSHSNLVRDDSVNEWLTGSHDNTPKGHQPVNTAHSAIPRDSSFASLTEGFDIVSPSSLSWAHPPETKLPTLNHADDYLSHLAEHSIGKYTFVLATAKWNRDIDQRQWVAIMMESTDLKSTFTETLHVDDFFNDTASASSSPYMATTINLPGWNHGPEVMGGLIDSDVDSPEGIWYGQTQAVTAKTARRGVNVPSFAISIDQADDELDSPGGLGAGLDQLSSDLSPAGSDGPGFLGAPSRTLRSCISAPLLQRDDPVLAAAGSQTLINDYLIDVGFPQERIPGDNALGLELGPRASTASSPANDVPGHPQTLLPGDESKDRVPALTELSGNASVAQSSALFQRRAVQRDLSAPSPVAVPQGGEGDQTIEVAPGRTVTIGNPAESTIDPDKMTDEQRKRLAQLHQIHVAQQAARLGVYQDFVTPSQQFAGQEASERAAKAVQAALMYGMEGNSPRKLSLGSTGLLTPVTPQHPLQPGPSGMPAYQHGVQGYVPMPMQGYAGFDPRVPGMPLSADSASFAPSIQNQFSNLHLAQQQGQPTQQGVFTPQFVHQHDATLFAGSVATGSQDLAGYTSVYPPPRHNSISGSSVGDRGLHALTLNPSGMVSATGHFGSSGEQMLLPPRRASHAVLRTTESSPSLASQIAANPMQLQNPFVQQQQGAATLEPAKLMAGPGSGLVPPTAATPRSAPADASREHLALQQTRMRQLQQQQLQLLQMQNQARSSNPAPKAGPSTGLTTRKVPGTLTGPLSPPRSPAKMKSTPHLRSPMVGTSALPPSPAKPLAPGLRKIASNRRITTTTTGSGGSSSSSSSSVSASGGVLRSKGSILGNTGGFTLELTTSASPTRARTISHQSASSSRSHSSPGKSKSPTPMATGAAGFSQLAFVNYGMNDADEICSAVAPSGSYKVPLRGFGASSGEEDDFDDETSSVRTRTMSNVTGTTAMAGSDDDDFDMTSPASASGAVPGSPTKRLRKNSSRPMLTASGSSPLKSKRSMASIGSSRTWDLNRSPRKAKSGILSPVSSAGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM63</accession>
    <name>W3VM63_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM63"/>
    <dbReference type="HOGENOM" id="CLU_273758_0_0_1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="903"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="911"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1172" mass="127989" checksum="D0F55C218F288F03" modified="2014-03-19" version="1">MSDHQHPDQPLQELATAAQLDEELEQQQQKEQEQRQQQLLQQQQAQLEARRHAEALAANAHAVDASNNVLLPISGAPTSDHLSSSSLGDVDAVIAAAVNASKQHAEQERRQEEEQRAAQEQADTAMDVGTPPHAQPQHAQPSQAPDTATSAGAHAQSDIDPSGAIADSSRPHAHASGADAHRSMHHADDADTSMITDAGSPVKQDADASMSITGTPKPKKERAKPKPRSKSATKITRFRKITSCLQCREKKQKCDRIKPICTNCRENPTDDPCHYVDDRKRPGSDEEDFAGDSSIGSPMVRKRKEPEDAFGSTNGRVFKRADFPRLDDRRQAVMVQTRREQVEKLELVGKDRSRDFNTRVNAARAAAIAGVLFESAITLPTADEISALLYTFKTQVEPFVNVVVIDINIARIQSFLRWWHSKPTTMPADPPLVPLLLVLLALTLQVKRNSPEHEGHNMRNFDPIPGVQCSDERTLLSVAGHCIDALQIACPSAWSSAFQAPIDLIKASLLRGIWHLNELNLQFAGTCFALTTRLAHAAGLHRDPEHWSGMRIEEAQARRNLWWNIVFYEVAHAHRIGQPPCLTHEGFDTRYPDDYDALYAMYERAGLADPDPSRIILPPGATALVPRVPSQANFDYHWSRFRIYHIFLRQSQQLFRFGISSPPDPNLNDEYAKWRENLPDKLKQHFERRSKGSVRPSDELLAQVAAQSFDKGVYDPKITEELQDYQQAYSLEFIYNQCMITLHRPYIDEQGAWKPPESVQKSLEVCLQSAEALISTVEDVLAVKPANSMYNQCAYFAFNAGLILAIHCKLDPSSQVHRPHIEKALHLLDELSSMLRLTNVAEQAGRYSSTLKQMLHGIGGDIASLATSKADGSAAAAGTGANGESIVDAKSADGARASGIMGAIDPSLGESEAKDGNDDSARTDVDGGPDRIPAFLLPFVGLPTDPHNLGPQTGNSYWNEALLDRPLVGVPVAYPVGFGQAILNHSDQHNGSAWASEQQQGEADNGGASGLPTGAEAHSQAQEATDAGAGTSGVEGGEVGESSEAYNLYELLGGRELGTEMPDRPMSFSQHYNHQNPGRGDQASSASYRTYVQNSLARTYEQQQAKAGTDKAENGLADAMPSESALNAVAAAAAAAAEAEGKEALDPAAQGNNLAGMWYAWENFSQMLNNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMD3</accession>
    <name>W3VMD3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMD3"/>
    <dbReference type="HOGENOM" id="CLU_020352_1_0_1"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="332"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="458" mass="49809" checksum="AF06ADB874C99202" modified="2014-03-19" version="1">MEVAKGWRWSADRGAGLSSHHHPTQNIESIRKMQRSKHDDAEDAGHVLCLNAGSSSLKFKVYRATPELHAVLAGSVKLTEHNARVCIQHESGEYEEEQDWRAISPGVLHHVLALLGRYEELAIRTVVHRVVHGAHLESGLAITRSDQHHLQTLEWLARFAPLHNAVSVMLIRACLASPVLRDCENVCCFDTHFHATIDEVRGRYMLDRELAGSALPGGMEMRKWGFHGLSYEAVLHTLPALLGRERGEVNAILCHLGAGSSVCAVVGGRSFDTSMGLTPLEGLPGATRCGTVDPVLVMHIPNANERQPSGVTRAEAVLNEQSGFKAVAGTSDFRTIVQRHKTDSSEGKRAKLALDVYVDRLVGFVGSYAAKMSARGGVHAVVFTGGIGEASQELHVALAQALAMSPLAPADSATKASEDCRQLRRAELGLEGDGSVPWLVCRTDEEAQMARRMMKMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMW9</accession>
    <name>W3VMW9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">IQ domain-containing calmodulin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMW9"/>
    <dbReference type="HOGENOM" id="CLU_472615_0_0_1"/>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="65170" checksum="CEAE7B38EDE5F5C1" modified="2014-03-19" version="1">MVSTSDPVTVEPAADATQKAPSDGKGPTASIAPSPARSSSDDFTRIDAADRIRSVMRTTRLEKTLEEQRRGDKNDPVSRWQRGGVMAEQLGQQDHAPPAAVRGKASSPPPRLHHRTSSSSSSSSPNVNSLSRQLMSTSFFDKLPFTFKNEAEKDEFIRESKTLTKRMEDQNWLEMLDPKHRYGSNLKHYHRHWNLKADTRQNFLHWLDEGEGKDLSLEECPRSKLEAERITYLTPDERRNYLTYVDNDVQLPSNGHLHDIRAHLKQAGKGRLRWCRTGELVNTSKYDHGDLGKGRGVALRQSQEWQNAIARGEACDVVRDDKIKFRRTTSASSSDSFTSDSSLSDEDTAVQESTPRDSTSASSETSSNTKGSAHISSPKPARDPEEKQQSRKEKLLEKANLGPKYLLKQKLGLYTSAERQQVVKGDQEDGSHGDDGEQDALIRKRKADTWIFVTDLSYNMYIGIKQRGRFQHSSLLAGSLVTVAGVLKVKDGVIVSIYPWSGHYRSSSQHFEEFVKRLQERGLDTSQINVTKSKWVIEVVNRYGMYRKKKDRKLKDLKDRARETWDGHRSPTSGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN56</accession>
    <name>W3VN56_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enterotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN56"/>
    <dbReference type="HOGENOM" id="CLU_1098889_0_0_1"/>
    <dbReference type="OrthoDB" id="10314509at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834717" description="Enterotoxin" evidence="1">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28136" checksum="6D64BDAADA6A7E59" modified="2014-03-19" version="1">METMMLVVRLLVAISALFTCAAASGSSAPGFAASQLRPGTSLDFDEVSHGIYTPSRASAISHDAVPAEFGDKYFMSGAPIFVFPHRGSRIAKSSLDEALATFGRFHIYSPATRQGTSIKLDPRQAGLVMRTGEFGDVREYMQRVDATRVWFGPHATMLAHGAPISKITRKYPWSRAGIRTPEWDEIWKAKARPHDARLSKPEVLRAYLRDTLETNRHVRFETRHGSMGLRALPSGQIEKAFRDLVGETTYFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNS7</accession>
    <name>W3VNS7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNS7"/>
    <dbReference type="HOGENOM" id="CLU_357223_0_0_1"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="2">
        <location>
            <begin position="212"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="833" mass="90765" checksum="0215637D31F9545F" modified="2014-03-19" version="1">MKSAQLILLMRDERVHNAALLPSLHVEELPMSSAARYPAATTPLSRPHLMAREPARRGAPSPSASPTPSTVAAFAMRRDTASPFASSPAFRDVASPMSASHASVSKDAARATLSPRPMSPAAYRLDASASGPSSRPNASASFSSRSATNAKLDDGFSTRPAERTSIRSQQGGDQTPSTRSSDKSAERSFYRRVLFQDLSPNAEAPTITHDADLDHEIYLLLAYLLRETVLPWYSKLTPDREFLTQVTSIITAIVHTITERQLFPAQANASSPATNESDIHAPRTPAQSDLVRIHDLLSRDIPLVLRQHCQEFRLACAKAGSVWAPLGASATPPTLTKDVSSVEHDEQRRQQVHERLSAEYQSAFLPSSKIDSASASPLQVAQLLSAACPHPGIDGASGSLDGKVDLTYLRIAVLNLLSSLMPADEFTPDTEKFIVRDVLVTVLRGALARSFRPWFFVQSMHKALDAAGWPSHPTLPSSEPAHRLKSEPVQTADTPAPASQVTASILTLISRLPLLLVNAWTFLVLRALPFVVRAYLDLFNVHREASRKRRRRQQRQVDGGSMHVRTSSTSQIPPSLSTGSLNERKMHGRYPSRKFQFGPDGTLLDRGNSSGAAKGVDETRETEPTGTVATEDVEESHPLHDYVGNWLGATEEILQVSSHALLRTAFGFVRTALGASGMDAVLNRMIVRKINAALRDTQTWTRMVQELRRILLPNGHFPPSVPDPDVETQEAEWIRLRTRLVCSPSGSAVSTSDAQQESLLARISKKMLLGSAGTSLGRGDRASKVRDTQDQLQTVTAWLAPFCSPQAAGPNTLFAILLFERVVVTLCPDLTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNT8</accession>
    <name>W3VNT8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Chorismate synthase</fullName>
            <ecNumber evidence="3 7">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="7">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="3 7"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNT8"/>
    <dbReference type="HOGENOM" id="CLU_034547_0_1_1"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="448" mass="48050" checksum="C5E5A1D176ACD68D" modified="2014-03-19" version="1">MSTFGSHFRVTTYGESHCASVGCIVDGVPPGMALEPQDIQTQLSRRRPGQSNLTTPRDEKDRVEIQSGVERGVTLGTPIAMLVRNQDQRPHDYTDDTLDAYPRPSHADFTYLEKYGVKASSGGGRSSARETIGRVAAGALAEKYLKEAFGVEIVAFVSSVGKVHVPRYPGEQLAKDVVVAAAKADAAEGKSFYGESATDGPPQTKVDNVIDTEGLTEEEAEEPLSKEFRQLLATITRAKVDENAIRCPHELAAERMRQRILLAKANNDSIGGTVTCIIRGVPSGLGEPCFDKLEAKLAHAMLSIPATKGFEIGSGFRGTEVAGSRHNDKFVLKQGGRLGTMTNWSGGIQGGISNGEDIYFRVGFKSPATISQDQATATYEGKAGTLNTRGRHDPCVVPRAVPIVEAMAALVVMDAVMAQDARARGAERLSRAPVQALPNSMKMPPKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNW4</accession>
    <name>W3VNW4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNW4"/>
    <dbReference type="HOGENOM" id="CLU_035254_3_0_1"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="219"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="432" mass="46328" checksum="4A790BFD4173C770" modified="2014-03-19" version="1">MTADLVTVLAEGTFEEQIVEVSAFLSRSQAEASRNDFVQRFQQLALEAEPAAPAAAADAAEGAAASSSDPAKKKQTVQQLVSEVKSLGEGTDRELEGVYNLLASLITSTFGDDAAQSAQLLSTLVGAVSKEGAAEKNNVRYRILSNLFNSLPASSAQRLGIFNALLALAAANDDLDYLTSSLTALPQWLSQWEVSEADKAACLESVAKALEGAEKEHGQTNKAYQFLLLHLRFISNGADGADTKQAAERTVAAALRLPKLYEFEELMQIKAVLGLNGTPVFELLKIFVGGNAKDFAAWKQANGAELARLGLDHDQLVHKMRLLDLADLCALSVSSDVAYADIAKTLEVGADEVEVWVIDVIRAGLVSGKLSQVNEAFRVYKSTHRQFGKAQWQQLEARLVQWHTSIANIIDTIAATRGGKLPDAVADTAVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNZ9</accession>
    <name>W3VNZ9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNZ9"/>
    <dbReference type="HOGENOM" id="CLU_043418_1_0_1"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="296" mass="32833" checksum="BDF293D546383E77" modified="2014-03-19" version="1">MSMYTVGLKALLPTLGVIYGFQAACAAIAVPLKTEKYYDLCGSLGFISAAGLSLYMPWIRARYVDGFKNVALPTSLSAFHPRQTIMTALTLVWAARLGSFLFQRIRKSGTDTRFDEIKQSPPKFFGAWMMQATWIAITALPVYLVNSIPKASQPPLGTRDLLGLAIWIAGMGLEVAADRQKSQWRQDRDAGKHNEPFISSGVWSWSRHPNYFGEVSLWTGQFVLATTALANAGTFYPTWAVGLAALSPLLEYGLIRFISGVPLLEQSAEKKHKDNPQWKKYKNEVPCFVPFVGSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP18</accession>
    <name>W3VP18_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP18"/>
    <dbReference type="HOGENOM" id="CLU_046329_0_2_1"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="288" mass="32417" checksum="96C3D364EF0EE5E4" modified="2014-03-19" version="1">MSTSTPEELLKNAEKKASASGGWFSSATSKQEEAIELFKAAANKFRIQNRFEEAGNAYMRAAETEIKTGEKDYAANTFFEANKCFRMSRPELAVVALTRAREILIERGRFRQAADREKAVAELYKNDAADPEKALEAYEQAAAWYLQEGANATASGCYREAAQLATDLARYPQAIERWEQVASMSLESNLTRYSVKDYYLNAGMCYLAIPDYVAAVRAMQFYAEQDTSFPTTMEGRFLHSLVQACEEGDLQAFDGRVQEYDRTKKIQGWQASLLRAVRKGIQDEPDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPB2</accession>
    <name>W3VPB2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPB2"/>
    <dbReference type="HOGENOM" id="CLU_000524_2_2_1"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="11">
        <location>
            <begin position="361"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="450" mass="49441" checksum="D25E1A9BCB91AEDD" modified="2014-03-19" version="1">MAKQAQGSIGYNQLERIDTLLYLMVYPQEPMVKTRTIELVGYDKLPAGQNAMVAVMSFSGYDIEDALLLNKASLDRGFGRCQTMKKSSTVIRKYPNGTHDRLADAPVDEATGKRQKRYDILEADGIAGVGERVDQGDVYVNKQTPVNANDNSSTAIMIGASNAAASVAYKSAPLSYKPPVSGYIDQVLITDTDSDQTLIKALVRQTRRPELGDKFSSRHGQKGVCGLIVQQEDMPFSDRGINPDIIMNPHGFPSRMTVGKMIELLSGKAGVVTGTLQYGTAFGGSQVEDMSRLLVENGYNYAAKETLTSGITGQPLEAYVYFGPIYYQRLKHMVQDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGATQLLLERLMISSDAFTVHACQRCGLMGYNGFCPYCSSSKHVVQLTIPYGTKLMLQELMAMQVVPRLVLEDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPE4</accession>
    <name>W3VPE4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein dltE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPE4"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_1"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05370">
        <property type="entry name" value="SDR_c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28631" checksum="7817813A502795CF" modified="2014-03-19" version="1">MVGKVLDFQCAVITGGAGGLGFAMAEYFLSLNKKVILVGRTESKLAEASKKLSDTPYYVLDTGNVEDIPAFAKKVLAEHPEVDCLINNAGVQRPLDVQNLELDKVDNEININIRGPVHLATAFLDHLKSKPLGVIANVSSVLGFVPYSIINPIYNGTKSFVHFWSETQRVQLKNTSVRIVEIVPPSVGTDLHRERENPDDNKKHLGATSSLTVEEFMEDLVRGLEADQDVISAGSGIPLVQKWDDAFRVQFNTAAAKYQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPM0</accession>
    <name>W3VPM0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPM0"/>
    <dbReference type="HOGENOM" id="CLU_032142_2_1_1"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="536" mass="59389" checksum="8A28ECDC8810B18E" modified="2014-03-19" version="1">MNAQLLNPFTIDIPDSVASTIEAAECTTCVFNHGLNALHGQYLAVGRSDGYITVWDVETKSVVRVLSGHVRAVTALAWSSYNRYLASCSADWNVIVWDLAAKSHPGPALRSAPSTSAVPRDSNGESAGVPATSERKVTLRFDCPIASVQFAPGNSKKLLVVLASNQAWLVDITEKVRVRRRAGAGIELEDVATSPVRVGLHTGVEAESPAITAARFTPDGRFIVAGTSKGSLLVFDSQTGMPLDEKNVLATTSGVKKLAFDAPGRLMVVNCNDRALRVLAVSTTELGAGGEDDRRTKRRRTSLELTLQHKIQDMIQRTAWNDLGFSPDSDYIYAGAAHKAAHNVYVWDRTSGTLVKMLEGPKDWLVGVDWCPHRPMLASVSNTGTIYLWFTPAEEIWSAYAPGFEELEENIEYEEREDEFDFIDDQDSKDRQKQQEQEAAHVRIQPHTLTAPTTRETLDPDHLFDRLNIPHQQRGQRDCLAFRAMARYLQPIEATSQDTWQDTDEVVLARADDDTAELFVIPPRLESDYSDFHHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPQ0</accession>
    <name>W3VPQ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromatin assembly factor 1 subunit A dimerization domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPQ0"/>
    <dbReference type="HOGENOM" id="CLU_012467_0_0_1"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="7">
        <location>
            <begin position="615"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="805"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="945" mass="101752" checksum="AA70CCC2803CE068" modified="2014-03-19" version="1">MSVLAPPPSPPPSSCFDAMLSDTDINIDRAMPPTSLKRKASSTKSRAAASIHSSSSDAENRPLIQSSSASTIAKPKRAAKVEVADMAPSKSASTSSPGPAAKKAKLTSSAALVELKNGKLVLKQKPFNWASTMPVLKAVITFQEYLDVHEKLDSIPQDHLHVIAKLAQESDKSLVELAKAIRSKILPEADLGSSESDDSATSGAGAKAKLPLSCIQAAISAVAERRNYGIDAAIAAPHASGSDAADAVAVPAPLQLWRWEATDSAMLPSEFLEKLTQRRNERESARTQAEQLFSSLTEQERQALLSKSTKAKISASITADAQGHVPAGSSASQPIAIDDDNDDGSVADTEHDRKAAQAPSTPVASRKRKPPSSTSTPQSAAKSSAMAGDTSASATSSPREKKKAKETVELSPEKQKEKEEKDAAKAERLKAKEAKRLEREAKELGKQKAKEAKEAEQKKAEELKQRQVNFFTSFVKKAAPKSPSKSVVAAAASSSASGKPAEDVSDFDRTFLPCQYKDLAPINRFASRSSSKPELEMGQDDLSRDEMLSQFLTRASALSGNAGTRARRRKGVHPPASVREIKRVVTESDVLGGNAQEQAEKALETLQDRSKVQMKLLQFESDRRPGWYGTWTKSTNLISPRCPLGQDPVSLDYSYDSDADWEELGQVEGEDVQDGEEEKEDSVGDSDEDSEMDDWLVDDLEVEEEEEQARSAANAMDVDDEIVEVDNLGMPVPAQPVTTNLLHPKKKKKVKLLGRRFDAKLVPFSTGPHWEREFGRCDYDLFSSYRIELLNDACFGLNPFTFTSAEPASSTTEPDEASIVDTPTKPRRGLPAGGVLAALWGDVAVASDAPPAPSASTADKPEAAAPTAFKHQLRPDAIAPLLARIHGSTKTRAGLVDDLKEMLDQLAMPASKNAIGERLTAYATKEKKPNAPWVVKPAFAHLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPT7</accession>
    <name>W3VPT7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPT7"/>
    <dbReference type="HOGENOM" id="CLU_584116_0_0_1"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="461" mass="51965" checksum="119957F7D374FF1C" modified="2014-03-19" version="1">MVKDFVHQSSYDHSWSSCVRSYFLRYPNPSASHVLSVDVIDRRIEYRPVRSGSYSTPSSSSVTLDSQIDTIPVLCTTRLILKRGNLPKWAPSGIIKNAESWVMEQSEVELDLFPPRASATAQGSSDDGSASPTQLDTSLKGRTKNGRAMRSWTRNLDHTTVLAVTEGLVYKERFGFMLPSEASEGDRKQSAAGAEQAVWRSYCKTLTTAQIESQMSFGMLRRRIEKFGLARFVAHKDTSQQGIMWTRSQIMDGDEQRLGSTKREHDVLQRTSMPQKRIKLLESLRPPFLDGYPLGPWQKLKMWWYSGHYSQVKELQDGYLIERDEDEDVDPESKRSRQATESSSDGSSSGETELRFRGAEQEGPWAELSGRKGKGAVYSDQDRNMEEGVLNRVRSRLGLPLVQPPAANEAEMAGRRPNIIAQALVRARVKAKSLLGFDEDEVHAKQQTQGRLAQIDRDRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPT9</accession>
    <name>W3VPT9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPT9"/>
    <dbReference type="HOGENOM" id="CLU_612695_0_0_1"/>
    <dbReference type="OrthoDB" id="2550581at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="433" mass="47507" checksum="7D429124FA100C88" modified="2014-03-19" version="1">MRSPPPADFLAQRSCETSFAWISALVGGVALRDDDLAPTMVLFFMLLTFLVIGGLRVYQGRRMTRILVIFVPTLCFVLCLDIWAALRADISNRSHASASLVQTREGLAELVAANGSVGCAPMMLTETSHQVFGLLAKRIDPAAKRWIRYTAYVARLLNLIALIMVVIATCDLASYLTAWLDQTRLAAVAADAGWTCETSTLGRDLTLLPLVASGTQVVTLSVLTILLVCIRLRYRLAFGVMLHLTCIQLCLAFHYTWRCARDWSSVQLYLGGDWNHSSPSSVETEGLQDLAHLLRRDAEDPTLLYLLGVVPLVLAMILVYLLNLTVYTDPPTVVAAAPSRTRFRLMLDPAAPKIELLPTKAHASAGKDAGKGKGKGDTKSTAETLVVKRGWLGGWTVKSATNEPSWMDKAKMRARRNVRKWIMGWSSPSSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQE7</accession>
    <name>W3VQE7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Centromere protein W</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQE7"/>
    <dbReference type="HOGENOM" id="CLU_2470046_0_0_1"/>
    <dbReference type="OrthoDB" id="2543597at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028847">
        <property type="entry name" value="CENP-W"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15510">
        <property type="entry name" value="CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8757" checksum="19F2F4D6D3086C1A" modified="2014-03-19" version="1">MKLPARSLIKKLVRAHLPPNVRLSKSADLYVLLAFLIYMQRLANESRLAHQQDASNGLKGSATIARRHINGARKRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQM5</accession>
    <name>W3VQM5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQM5"/>
    <dbReference type="HOGENOM" id="CLU_310588_0_0_1"/>
    <dbReference type="OrthoDB" id="2550803at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="947" mass="100770" checksum="DD09BA70FFB04F67" modified="2014-03-19" version="1">MTSRPATQSGIELIWVNASPTGPTDADASDPSQHRITRVQSGLKKLVRRSSAEQEEADAIVNDLANTIRFLAAKTVSREHAVIGWAAGVPFVEDLGSTHGTFVARRHATFDPQGQVLEQDASAELLQVISITKLKHGDLVQFGKTLSRGSTHYYPVRCYVRYRDAPTPPSFSKVSAAAPTSVSAAKSSYSYGLDDATIDSEIVSIDAETFHKGVSPVTPSLPKASNSPTLKDAVDPRHFEQAEVEVGSSDSEQSCINVDSSDSDSDAGTNHSHSDSENICSCSECHSTESSGPGDVSGDDSDLPVRIDEDDDGVCASSASEGEEQDSSTMDSDQVDPAICVLRAPSTNAHTDTEGSESPTQESASIAPASSSTSSNAESLLVAMEGEVKPATAKDSSSEAEEKETPIPDAIVSADEKEEAQLTPSRKRALESPEDDRASTDESTGDEDDNGTDSDKSFEASSLASALSSPCTSISGTPSPPPAKKRRISDASHEDRRIQPRPRSRGRSVRVFFGKALYTASLLSIGFFSGSLFTFKSMLNAAAAANAAGSDLRTRRSPKQLKRLRINGDDSLGMTHAVVRLTDEASKSKIWAVHGETSKGKCLVLPLRGATFDLVQEAEEAIYDDAGDAGDACSRPTPSPPSFLEAIPLPDNQPQLRRVKVSRPTTLQLTSSSTTPATRSSNQIAASAPPPPSCNGSSAAEPSPKTQATAADSSIPSRRSQPILPVKLNPRAHRIPSDLSSSIIFTFFFNLSGAEAPPADVKTSRGPLLRSSSTSLAAATKTLLDQTFAPAEFESVLQKATKSRYAAGPNGLPHAFWVSNIPISAKILCQVANAIRSGRTLPPYVPIAVGTLLFKRKVLDSDPASSLPLTVIDSELRIIDTVVQRRLTSAVDQPTPPSQTGFIPQRSIFHSALADQLVVLLVKCETHSDRYRLPRRFPVGVLLEKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQU8</accession>
    <name>W3VQU8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="14">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_02957</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQU8"/>
    <dbReference type="HOGENOM" id="CLU_003818_0_2_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="642"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS63177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="727" mass="79205" checksum="0118BB5DBD50B8E7" modified="2014-03-19" version="1">MPAAFLSLASRFAAAPERRRVRHTLDASPLASTQHPPQHLALFFGMRLSSSAALCISTAEGPQFQTAVLAAESIRQLRAPLLPHMLALALSHNRAWCRGRLDLRLQPAGAHPVDPAALASPISAPGLSRYLDIMLSKNFGALLSALLLVAAPFGAEAVTIQKPGLKQSETSASRANQIKAAYKTSYQAYLKYATGHDALLPLSNGFTDPFGGWGASVVDSLSTSFLMGHMDLYNQGVEYSKKIDFTKTSSDTISLFETNIRYLAGLISAYELGGKKEQKLIDQAKVVGDHLITGWLGNNPLPCNTLKWNNLATPDACTSSGIAEGGTLILEMDRLSKYTGDPKYLKLATKSMKTIAQSKGVFPGLFPQVYDPKTGLPKDDYVTWGGGSDSFFEYLIKYAYLTGDDQSLWIPTWVNSVSSSIEHLIEHPEQTQAKQLTYLTDYSASNGGNLPRWSHLGCFAGGNWILGAKMIGQDAFDQYGQALTAACANTYTASPSGIGPESFVFIGTNNNTDGVRINNAAFYRKNGFDFEVTQYILRPEVMESVFYAYRTTGDARWQEIAWNAWNSIYRNCLVTQNGALAALADVNSTSPTKLDDSESFLYAETFKYLYLIFADPEVANLDKYVFNTEAHPFLVDQPQKASYKSPAVNVKPPKKDKPKKAKQPSKTDKDAPVPMFSSLPGLKLPEGGGNTLGNLLGSIGKRTASQVRRHRGAAHKRRQDGDAAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR68</accession>
    <name>W3VR68_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01301</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR68"/>
    <dbReference type="HOGENOM" id="CLU_011862_0_0_1"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="11">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="529"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="742"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="657"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="779" mass="82992" checksum="090F762918D8B96D" modified="2014-03-19" version="1">MSALWSGWGADAFTEQVEKATSELLPVGSEDIALNLDICDQVRAKQVPAKQAMQVLKRRISHKNPNVVLLALGLTDICIKNGGDHFLQEVASREFMDNLVSVLRNPAGVNNDVKAKALGLIQNWSQIAQAKPAQMAYIIDIYRQLKSDSAFDFPPLDPNAVASAALVETLTAPEWVDGDVCMRCRTAFTTFNRKHHCRNCGNVFCQQCSSHNMALPWFGIGQDVRVCDGCFARKGPPKNAAKLSRSKSAGSSSTYVPSGRGGSASHHRSATLSGQTGQSKRSARKKEEDDLALAIKLSLQASGQSAPQSSRPEAPSNPQKAPNGRVLEGTDADDDPDLAAAIAASLRDWAPPQPSAPDGLNEASAPAASTAHASEPLRSDLPLPPSLDLAPQDVDNILTFSQSVQAHHHQNQRSGMMGAPVPHQVQSLYEKASAARPRMARNLEEGHRRHNVLVSMHDKLTEAVRLYDRLLDAQMYRPAQSYAPNAPSHAPYAAPAQHYAYDQHAPSHEAVPGYAPMHPGAASLYPHAPQAAHAPQAYPGASHPEYAQAPTQWQPHHDQPMYSQQQQPYPTQPAQSQSQYLAGPSAYPAQQQQYGAPSPAAGYPNAHYADPQATSSAPVASPTQHASYAHAGGMPNAPAHPHASGAPYDAASPYTEAPGAVPSAPAAGRGAPLSQQPQQQQPFSSKSPTASRNASYNIPQQQHQQQQPAKADTSYLPIFPVAPHPDNGFGHDARAAEAASPMASPYTNAPSSAGMWQNGPGKSPAAANAPVAESPLIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR80</accession>
    <name>W3VR80_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR80"/>
    <dbReference type="HOGENOM" id="CLU_1008741_0_0_1"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="276" mass="30337" checksum="56980CAFEEBBB030" modified="2014-03-19" version="1">MPSSSTSIALFQVLFTPYGENVLLVSQQAGRCGLHGRTSVSSVSNEARPRFRRVMPRSGSSLQKLGQSTRLFAAAPTPMAANFGAISFRPVPRPIEPQRPDAQPSAVGYLRPSHLPRTPDRIIMMNTKYIESSTRSRQKKKGMADNSARLGGGLVALQIDQVARKSEPTRVVHAAAKVLAPSSLILLAAYHCRLLAPHSNMAGNAGASSSRWYRPMPGFAPHPPAFKHRWGAKLLGATMWFWIFYRAKQDGPVLLGLKHPWDGHDHHHGDHDDSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR81</accession>
    <name>W3VR81_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR81"/>
    <dbReference type="HOGENOM" id="CLU_2292894_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="101" mass="10961" checksum="AFC92F0EA2843EB4" modified="2014-03-19" version="1">MPSVLCTAELRVSIRRMFLLATYHFDGDVWGDEKSGLHTSLARSSNSENKASASNAAAARTPNLGHKQSGLEPRRRLSSLTTALGLQAEWKFSTTSKLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRI9</accession>
    <name>W3VRI9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enterotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRI9"/>
    <dbReference type="HOGENOM" id="CLU_1098889_0_0_1"/>
    <dbReference type="OrthoDB" id="10279825at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833322" description="Enterotoxin" evidence="1">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="30189" checksum="21FB1BDE0792CBA9" modified="2014-03-19" version="1">MLVWSLPAKILALTGFFICAQALPGPRASVLSKRMYATGSRSTSSGELSFEDVYNGGFQPALGTRGITRDIPRFYNGMYFYHRAPVLTFYRGQRIPKVDLDVASATFNKFHVYDLVEGRYTTIERDGSDAARAIRSAWHGDIEAYMRRAFSTSGRFGRHISLVVHCHPVETGRYKKIAGFRWPESPPTWNTVFRTVPFRQDPRLTQDEAEEFRLNLRRKLDTQRFAHFRSLDNSRAIGIRALHNGNIEYEVRDMIGRVSRFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRN0</accession>
    <name>W3VRN0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRN0"/>
    <dbReference type="HOGENOM" id="CLU_1587211_0_0_1"/>
    <dbReference type="OrthoDB" id="2553635at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="168" mass="17956" checksum="189756E3F98F6956" modified="2014-03-19" version="1">MSLAFVIQCAFSGGNPSKLSSELVSEDGIAKTPDQRTYPVAVKTLNLADFFDCLDAPGYPSDQIIYAVDRQGVYIENDMGDVLDNARRSTEDCNHVVTDETTVLDHLTFFHGPSLGGRSVSFAAGDETIVGSNIAADQSDPDPAAVLPVQPISPDFWAARHGADFCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRY6</accession>
    <name>W3VRY6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRY6"/>
    <dbReference type="HOGENOM" id="CLU_019105_2_0_1"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="10">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="394"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="633" mass="69850" checksum="368A43B1096AA9DA" modified="2014-03-19" version="1">MASASVYYKFKSQKEPSRITFDGTGISVWDLKREIILQNKMGRGTDFDLGIYNADTNDEYKDDNFLVPRSTQVIVRRLPPSKPGRGTAQNYVADINGAADTTGASRFSSTANAGGVKPTDARSQPYRGPMTMRFDGRDASAAQPPSGGPSSSAAGLDPKAAATGDEADRIAAMFQATTEQWDETQERMSHATYRDRSGQVRRGGPPRPMTTQRPQHMPDRPPPIGYVCFRCGKPGHWIQECPTNDDKEYDNRPRFKRTTGIPKSMLKTVEQPTEEDQRAGVMLTADGTYVVARVDQESWRRNRVRTKPLTQSDVYQSPPTDTTLACPLCSKLLREAVVTPCCKTKYCEECIQTHLLEHEFTCAECDKRIADLEQLKPDEETRKKVKEYIRETIEQSERELEEEARRDGQGDAGDGVDKSDSKGDTSDAARQRTSSPGGRHDDKDEQAHRSGSQSEQELSYGDAGSAGQGAPGGVVFNPQMVQQIMMMMQNPQLPPPMRMQLQMQLQMQQFAFMQQMQQAGAGSQATPMQMPQMPQMPQMPMGPMGQGGQMGSMRMGAMSNAGAPSWGQQQATQASNSYGNRGAPADENSAYMRIPVNQARTRTPATKRDRPTDFLEVGSNGSESSKSARTGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS33</accession>
    <name>W3VS33_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01906</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS33"/>
    <dbReference type="HOGENOM" id="CLU_809402_0_0_1"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="355" mass="38066" checksum="6F4135A42A5861A1" modified="2014-03-19" version="1">MPTKKATRSTRSTRSTKASSKAASSDVVFDENAHASDDPGAANTKAPRSAAASKKVLGERNANDTAEPSPVKDLAQPPATKTTKSKRGKKKAVQDIDTAKQSTDPRCTTPVPSSPTKKRLPEDQVQACLQNYDLECQARMSRLRASLEMSLQSSMTRMRLAIERIPRAVRELSLATFIDEYGADIHAFMGRAPVQHLQDTQKEWDQMREERSPIKSKRTNKDDEATAKSRDRNSKAARTVNATASSTASRAAASKASAAKASSAAARQKATRSTKPSSRSTRASAAAPSSPPPSTSSKPAPSLATFQPELPEQALQTPKPRMARPGEVIQWTSINGSPICGIIGEDGVVRPVSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS48</accession>
    <name>W3VS48_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS48"/>
    <dbReference type="HOGENOM" id="CLU_009666_1_1_1"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="157"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="691"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="838"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1049" mass="108345" checksum="2F9F468C207D8E96" modified="2014-03-19" version="1">MPLDFSTTADASNTHANEAATHPLPSATAPAHAPLQPVQQIAASSLAAHPRASPLKSPTGSASSLGFTTSALQRAGLLPAHPSSTMAATATPGGAGAAAASESLQRVMGHGAASAAATNGASTPLQAGPLTPAQLKNMTPAQANAALQNPVGNVPTVYLATYSNVPVYEITVRGIAVMRRRADGWLNATQILKIAGIEKTRRTKILEKSILTGEHEKIQGGYGKFQGTWIPLQRAQEVAAEYNVSHLLQPILEFDPATADQIPKLYQRKKPAPSARNSSASAINDGRSATPTKRYSPAPSSVGGPSQQPRFLALRPPKDSQNRDMSPALFMPPGASGLLGGFGVDAHAAAGPHAIPPGSSQAEQDALRSYNVYGYTPQGVPLPAAAATDASTAGDKRAAAEDEHDASSAAKRSRLASPQRESGLLLGPSPVKDLNALGPAGGSLRAASAPRGHRMAPYDEGEKRMRDHLVSLFSDDSVLAGVAEPVTATDASPSSAPAASATAASASTGAVANEAANGTADDDDAYVAKLDHLLAELRDKASLGGLGGSSGSEGPRATVDLVTDDHGHTALHWASALCRLALVRTLVARPHWQGGANVHAGNHAGETALHRSVLVTNSYDASSFPTLLKLLAPSLNTRDFKKRTVLHHIALVAALKGRAASARYYLACVLELVAADKSSKYKGLVDAQDEDGETALGIVARLGNASMVRMLLDVGARKDLPNALGIRPSDWGIESGGAETHDGASVAASTVSSLPPLTAADLASHNPADVISALTRPAQMPVMKSSDVRDQLSSTLDDLQATFARELGEKNDALATVQSHLQAATRDLAARRKTVGAAQAKLAERDEARQRAQNLRRAIIAQLAIDDADAEARLAELQHEAEAASAAKEAEAMDVDGDVVGLVESLASSIVAATDEVEGDAEVEELVRLRWVVSFLSHSSDSLAAHIGELEQAAATKEAQCKQVVAICANIAQDKVEGMLDELLTAMESDGPDVDLARVATFMGKVAAPEQGERKPGLSTSTSGSTNVSSAETAASSTVPAPAPKGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS72</accession>
    <name>W3VS72_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class ii aldolase adducin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS72"/>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="47"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="287" mass="31449" checksum="5D7FE5F13EE051AA" modified="2014-03-19" version="1">MSPPTATDNVPASQTGAKEVQKGAPKFKFPKPVTYDSLEAERQGRKERLAQAFRVFGHLGFEEGVAGHLTFRDPILKDHFWVNPFGVPFRFMTVSDLLLIGPDGSIVDGGRPERRIYNQAAFAIHHAIHTARPDIDAACHSHSMYGKAFSTLGRNIEITTQDSCAFYNQCALYENFGGVVLADEEGNNIAKALGDKNRALVLQNHGILSAGTSIEAAVGYFIMLEKHCQVMLLSEPAAAARGTKPIVIGHEEAEFTRRQVGSDQALAFQASVYFDTIARLDKGAWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSD4</accession>
    <name>W3VSD4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSD4"/>
    <dbReference type="HOGENOM" id="CLU_289701_0_0_1"/>
    <dbReference type="OrthoDB" id="2551855at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1058" mass="114553" checksum="21DBD4B97E7B3B24" modified="2014-03-19" version="1">MTSLVDLYNARRAEELGVPDPSTSAPTLTTDVRAEDTVVHRQRNPQPTSLADLYNQRYESERNPQVDHQSRTSLARPSSSRLPTQARQFTTSSSAVSADSDSDASTRFIRGFVQTETDQLEDEADESDGSDDFDVAMISAARSQSRSVSMSVAPQGAHVRYVPRTAVPRRGALNTSAAFLPYDDHDELDDAATPEPEPPSASASSNTAPLPVRPHPSSSKLVVQSESSDAPHTAESDTSEPPRAPQHSERVSLPRHTLADTEETSGTESAPPRHHVPARVGTARLQDMEADDDAVIVVVDDSSADEAYTRSFSRLPGQTSRSASASSHHGNGDPVVMIPASRQFTHRADVDMGSSSNTSRAPQPSSDPIAEGALQPKSIIISDSSSQATPATGSDSEAFRRYPKRARNVTDYNIRRAFERFERQLAQETSAQVNHPARQKKKTLPVVFASSEFLDRVRQGAASTSYTPPRPQSSFADFLLAKAQTAASAEPTVPAASTRSTRPTRALTEAKARELPSRILHPAAFWDFPVRADRERLAQLPLSTRRALGFEPAPPPTSPQIPPPAGRKVTFRELLSLQAQRPKAAQRRMQLESVVGEGRLGRPPHAEGLDSVAQQLRAGRSCKIPLPGALSVLSDMERREWLRFEEGQSDLERLAEEDRARERGLVMVDVNDCECVKTQIDSAGRTRFAKVTCATGGTIRVYFDLQRSEAAISQEEESEHRVEIVRTASPAKSTSASRLAGKQAVPSSDSAYEELLPDVVDVDDDESLVEAQMHDSDDDDTPIEVEMLEDDDDDDASVREVSPVPVASTALNRGRIDDLFSRTSRSPGLEQPSGSAANPNPRSGQAAAANSSSNSTQLAARAAISKSRSASGKSPRDLLSYFTLQSSPSKRARSPSPTGQRGALGSLSAVARGKQRAVEKSAAEDSLSTAEVSEWIPSQSPSQQVEVVLDAPTPVSMREIIGTPRKKRAHSPEAAFRKPKHTKAAKAAEPSAQQDRLARAPGIKPKKRKATATTAQPQRLPKATPSPSRGGWRGLSSWYTARDAFTPTPDTPNQRKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSF1</accession>
    <name>W3VSF1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSF1"/>
    <dbReference type="HOGENOM" id="CLU_801984_0_0_1"/>
    <dbReference type="OrthoDB" id="10061782at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="346" mass="37811" checksum="AABD8D3B62B9C971" modified="2014-03-19" version="1">MASQAHDRTAAPASLLARLYAGVAVTLALQLYRLLILVGRLHARWLATQSFSSGGSAKQREKVETYPQEALFGYDWYVWRFMLPFMWRADTELPARLYEATIGQRNIEVGPGSAYFPRRSAALRRLAQRSLVASPAAAGAQLSYDLLDLNPIPLQYSHARLERLWSVLARDVSGAGLVPHPPTVEAYPNTRRLAADITSLEQLQSVLAAKRVEQLYDTLVANLVIHCIPYAAVADRANGHELARRKMAAILTGMASLLAPAGSLVGCTVLGPRCADWTHDSAYSEAAAIDASAMLRRIGIFANEYDSLDAFTYGAKLAGLEIRVARVTGNLLTFHLVKSKPLNAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSH2</accession>
    <name>W3VSH2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSH2"/>
    <dbReference type="HOGENOM" id="CLU_1644444_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834547" evidence="2">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="161" mass="17224" checksum="3441F833A3CFF8E6" modified="2014-03-19" version="1">MCLVEIKFVWRCTWLVLVAHQTSARRSSYPPPSFFFYRPIQHLARKEANTSTSSAGSSNGSTPIGPLPPLPLLASLPHRILSTPVIFTLLADPLAICATLGPAACTFSAWTSQSAALAASNDSPASSPALSSCLRASPKTRPDRGPRNFIWPRSPILAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSL6</accession>
    <name>W3VSL6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSL6"/>
    <dbReference type="HOGENOM" id="CLU_436220_0_0_1"/>
    <dbReference type="OrthoDB" id="2107640at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="627" mass="68770" checksum="7DD1E2330D211413" modified="2014-03-19" version="1">MLMSTLLHLDSAAWGRKVNFTQYAAVAAELLHASRDAIEANTSFQELAFHAAGSAALPKASWLDFDAHPGDCACQIRPAGLHLLVCAFRSDPHKTKAKLQGTLDRLLEVATFAKETFHQLCTLNLNVAKIGAGLDRKSMILEDFCYAIGAGTWFDQICQPDLWLAASPSKSLRRTLVSQDDAAHLPTLANDSVSYKERTWPMHAGCKDLVAKHDDASAASSPSTASTRSLSTQISPASSIKGGESSSSLATSTSPTDTITFKIDTTEVKQPRVRFQVEDWNFVVRWIVICFSIGRYRQISPNKKNDALIYRISISDALKRLNIRDGALLQCKSAKGAHRCPHSKAQASVEAKATTEIERLQSWTSHASADLVINLSQLSNSSGQQVGESFSIGPREVGCVPTFLTIQPLLLAWKQLNLPIFIVLKTINMLIEAVSPQQAASADGAQGLSLPHAVFYSQRVCVSLSQGDPKLSNCRLVEEMELKDNVPASLLPRTSVGRGLDSDSEEFVRILSNGGLHDMLLAFFAQHRARLILTARSLFPSALYATRMDHSCDFPFPKADSKTLRAWHLEQQEWVNYSMQHGCNYENATAMVPRHCFYATPSELIRICEQAVHSGSTLSVPGFTQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSN6</accession>
    <name>W3VSN6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSN6"/>
    <dbReference type="HOGENOM" id="CLU_005210_4_2_1"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="293"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="294"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="437"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="497"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="561"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="619"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="697"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="761" mass="80206" checksum="C2B93524FECC641D" modified="2014-03-19" version="1">MLAGSRPPCAVTATAEPSQPVAGSAHLAAASRGKSDTAGPNQQKQQRVWSRGHHVWRQKRAFCAWTHKSRVYDQTASRVNFSARLRFPEFRLPWKKLKLWSGFSLSTSDPDQVATCPSTIILHRNFIRSDEPDKMAPKTTAKTAKPATKPASKAKKPLTNGVSSAKASAAKPSKAASTANDGAKRGQKRAKEVEEEEDELDEEQDTAAPLPDVKKRSAKARAASSEPVGDVEMADGTARPTKRTRRAPTPAGPINSVPRPIQPVHADDITQGVAVEVSTGTTSTSGKGAVLPRKLFVWGSGDAGQFGVGPPEDDKPNKLNKPKPFGNKEISMQIDDGDLGEGGIQVIVGGGMHSVMIDGLGRILTSGAEDYGTLGRKHRGAAGDAEESYFNFAPVEGISPSGRGINPIDGKEGTVEKYRATRIASADAAGAALDDQGRLRSWGYFKDGEGRVCFADTDAPGYNREQWYPIALPGIENEHFAAVAAGENHFLALTLVGKVYSWGTNTCYQLGRSSNPRRVSQKFKGEAPKDCDLTPTPITGLAECKRICCGLTNGFAVEKSGKVVGWGLNTKGQTGTGLKAAKVATPHAIAALSPVRHNGAEVVQIVGGNFHTAFLLSNGEVYICGDSDEGKLGLPAGHAALKGATSSNPVVVREPTLVPFPAPPSWAPESTKTKDGKTKIVALSAGMRFTLALAADGTLYSWGTTSDDALGHPADDVGGDQSKDTPTAIAMPGQPGAWRIMAASTAGQHSLAIAVKPPQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSP2</accession>
    <name>W3VSP2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TTI1 C-terminal TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_246362_0_0_1"/>
    <dbReference type="OrthoDB" id="49511at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1583" mass="167798" checksum="FA039359B0F25F8E" modified="2014-03-19" version="1">MLSSSAAGPFRQGPLGSSTAQTPFQRLKPVCVELLWLAGRSAAPAQTKEVVTSLRRLESTLQAVISEQDSIANDGIAGSSSSTSRLVSRTRITLPTSLVNYVFYPISELITAAPKGISSLAESVTESILDVLALLVDQWWADWSLGTSSSSPPASSKWQVWGDLVILASSVVGTAPNATEPRRSAGDEVKLAALRVLNELLTVRFEADPTPGSRGDSAAAKAADEWEWDGVSDLPSLDDAEEPSKPATKRSTSNKASSNEASTRTNHKVLFPTPEHFKHVAADKVAKGAISFVLSTSFALAESSSESTEVRTTAIAVARSTLLVWIGGVCPLPADADSAATRAPVVPLYCIGQNQGSNELANRKASSLRLRPLLPGITSSLTRLATSRVRTKQDGTKPKATPAPVAAAAIEVLGDLLRATVSHVCLDDTMEEHVVGGGQNGASMPDSSPFANLTDLSQLVDASSRDENGSDAVTDIAEAEPGMHPDASAETSNQGALKQEAKWALSTLAQIHLALRTFSPLTQPSLPGTSLPSTVPTVVQRAVLDLAVALLSDCGTSFAWLDDHLQGMARLDGTSAQADSAKPGEGTSTSSISTLLTWIVDLASESNTTSVVESAKFAFHSLQGATTLPALKDGTAFWSLLMQALDALPAAVTVQSDESVSRLTLRVNTLLQLAFARSEEHGNGAPARVREAALTQFAQELPSRILRLVALLKTEGLEFVDERSDIPGAHVGSRLQPAFAGLEASTSRHLSRMFFQLGRTLAFAFVQELGARQTGAKTDRGDVFAVVPLLVERAAKLRSIRLPGIISTGGADRTGREDARNESLSSLAVAAELMAGISSWIDNIELGLRFAGMANAAPASKSARKVAHRLGKKVFGLVVDMLDGDAEEAVAGRQRSDLVLSRADLAEGGADAIRREHDVVKGEGVSLQAVSDSLVERVKGISLATEDIESATPLRHGPALDLGFVRAANLSKVSGGTVSRAQQEQALQHRYVKAERSVDLSNALAFALVGSSSKLLGQNFRALLLRGAYPLISGMSASPTASSDLVRRASAAAMREIAFNTAYGDVKNCLLDHADYILGSACQRLISGLDEELRAIAGIDGRSKSGAAAVARGDGAVNAGQGDRIVLPLVSAQRAPFVLVEMIRVLGSEVVPMVEDAIDEVLDALDRFHAHPSICGGLLAVLDSILETMAAEQTAKQSSSSKARPSLLSVPDQRSQTEVEDFEAWLAARRREQAAFDEADGNAEAKQAADEKGDKPSKSQQVAAQILEKAAVFLTHPSPVLRSHVLELLRHGVETLAPQGRTGELLPIVNSAWPHVMTRLGASYSSGSTSRSSQLTPIIDLDRIAIGAAGRAQSDAFYAQNEAALVEKDPQVWVAAARFVEAAAQHVPDFVGKRVVEEAWPRFEQLLTLLRWKFHPRSGRAHASETRERHAVGLVHDLDTAPSNQKRPSTVHDHIQPPFILPSPTGVPAQLTLAIVTTLTSVVSSIGARLPDDAAWSITTHPFLLDLLDVRQPPALLSAAESLYVELGRRNAPATVWALQTAFPKPAAKALRESAPVPCFLAHAHAAVQEETLHQIVSLFKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSS8</accession>
    <name>W3VSS8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02151</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003621_0_0_1"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="1330"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="962"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1128"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1243"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1132"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1586" mass="170676" checksum="00E70352E822AEEB" modified="2014-03-19" version="1">MDKGKQKARDPELPVEVAPPQTTAELNVPGSSRIPEAVAIPNRAATSASRHGHDHITRESPSSFSDMTGSPGRRPTHTRAKSSLGSSNMFDFFGPSSIASDATAATSFHFGSPGTSPKLASTLEAASPHIASQQRDSLEDTVETRPAQRSALQPASADAPEHASASEEERLGPQESALGAPSAPMLPLYPDEILPDYEEAPEYTPPLSQPSSSSNRSKTSAFRTAAANRFLSSRIAKKLNLPPALQSRLQGTQTPDAHSSSQHYPPFSSAAHSVNRAPFARSDSAPDLARTRHASSRTPIEVRSYAATAYMDGARMGPAPRRPRLASSRPSTAHTSPNRSQTPDANSARPATSAGTVPTRGQPTASPLLRTAVSSAVPSRRNSGETRPPSRATVSSAPNGGLFTCGYSATRSGATTPTRPGSARKARSRKVSLRSLGDLFSVNRERDLPTPPLDQQEGRSRQNAPLATLLREVVSPVSSETLISARVHSSSLVRPALMTTTRSSAHASIDAAESGTPVLILPHQSRQDALHKLPREVVLTIFKSLVDLHVEEHKNAVQSGAWRGKQTSETRWVGAEAAVRELARLSRVSRTWQSYVLDGQLWQSLAFSDYPDMAEEAMISIANAVGPFVRRLDLHGLAGLRSSVLLALSKAQRARSSTGSELELGTSSSEMSAKTCQLEELDLEGCRQISTSALNIVLSRSPRLKICRLANLPCVDNTTLCTLAACAPKLEVLDVSRCANVDGEGIRAFFAIQESELNNSALLKERNVGSKFRELHAAGVAGFDSATLAQLGRHWPNLEVLDLSYCSDVNDAAVAALVSSEGDLVSEKGNFATLTPRQAGSQGDEEMARRTFPYLRRLNLSSCRALTDRACVSLSHAVPKLEVLELSNIGPALKDTGLVKLLATVPQLQKLDLERATQITDAVLSALTPPESHAEAFGLAVPDRDTLMNGVRPRGSLLHLARRSASRRRQANLSSAETQDDSPPGYSEEAVAALIPATGTRLTHLVLSSANRLTSEALLLLVNRCPFLVHLEVDDTHADNEVAMQFVQLARYRKVQNAYLCLVDCRSFSRDTYSHLNSADGADGGVRPRRGSRGYPFRHFFYDDADPAAGCAAAHTNASEASAAAAATSSHIADRSSRASLDGRERDRGYDECNVAKPVVKSFWGWQLVDARMKQRRKADQRAAAHRRHGGRNKMGSVVAMALGLPVPGLIGTDETTTTRHPSLLIGSLRGAGPRWTRMLATPERGSDDEAAAHPIQDDDDDTDDPRGAFRLDAPRLLITTTTRLMIRVGRLLTTRFSTTSTVSCSPLRAGFATSAIIKMKIHPVPVRDDNYAYIVQSSVDGKAVFVDPYDVPTVHKAASSLGISDDNIVGLLTTHHHHDHSGGNETFASTFPNRPIFGGSNQIPALTNQVKDSQKLNDLLQGVEITCLATPCHTQDHICYHLSDGGENGVLTGDTLFISGSGRFFEGQPHEMLAAMDKLSALPDNTVVYCGHEYTKANVAFSAAVLDKDDLKKVVDQLKADSNAVTTGVYSIADERRHNPFMRCRDSAVKNKLTKYADGKNLDDPATVMGLLRQLKNDGTLKANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSY0</accession>
    <name>W3VSY0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40s ribosomal protein s13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSY0"/>
    <dbReference type="HOGENOM" id="CLU_090139_1_1_1"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="6">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="221" mass="24697" checksum="1B83496B9DAFA71F" modified="2014-03-19" version="1">MGRMHCKCPPPSPQASSSAQQLGIVPPALSSSLRIASHRWSQQATPAVVLACTWSSFRIRCRKQQCIRLVSRSFTAKGKGISASALPYRRTPPSWLKTTPEEVVEQIVKLARKGMTPSQIGVQLRDSQGIAQVRFVTGNKILRILKSQGLAPQIPEDLYHLIKKAVSVRKHLERNRKDMDSKFRLILIESRIHRLARYYKTKGAVPPTFKYEAATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSZ6</accession>
    <name>W3VSZ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00675</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSZ6"/>
    <dbReference type="HOGENOM" id="CLU_060400_1_0_1"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS4 N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 central region" evidence="9">
        <location>
            <begin position="78"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="11">
        <location>
            <begin position="194"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="246" mass="27526" checksum="D1EB7013333D0FA2" modified="2014-03-19" version="1">MLDKLSGTYAPRPSNGPHKLREALPLVILLRNRLKYALTGREVNAITAQRLIKVDGKVRTDPTYPTGFQDVVSIEKSGEHFRILYDAKGRFIVHRITAEEATYKLLKVKKVQLGARGVPHVVTHDGRTIRYPDPAIKVNDTVRFDIESQKILDFVTFDTGATVMVTGGRNMGRVGVITGKERHLGGFDIVHIRDVLGRDFSTRLSNVFVVGTDGKPMISMPRGGGVKLTITEERDQRRRQKEARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT25</accession>
    <name>W3VT25_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00655</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT25"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="173"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="664" mass="72840" checksum="7FBABAB5A8582A99" modified="2014-03-19" version="1">MSQPTHQPHAVDGTEAAAPRGRFHQPKHGWMHEVQKRVVGQTPKGSPHATPRPSNVGAQRSRPTSAEIDRETQAIIHRAARYGGDDPRDPQDHAYEDGAASSDASTRVPSSPTHPDGSKPKHAPQREESDDTSEQGRPRGNPDEQEDPNQVGWDGPDDPENPQNWSQKRKWALTLLCSFLTVNVTFASSAPSSASQQLAAEFDIGTTTATLITSIFLAGYCLGPIIWSTTSELVGRKLIFSISMLMYTLFILGQALAKNPQTLFITRFISGVCAAAPLTNAGGVIADMWDPVGRGYAMSLFSCSVFIGPVMGPIVGGFITQSYLGWRWVFWIMLIFAGLCWIVTTLLLPETFAPILLVRKAKRLRKLDPEANKELYAPHEKSDWSFKGVMHRTLLRPFQILAQEPILVLITIYLSVVYGVLYGLFEAIPIIWSELRGFNLGESGLIFVAVGLGTTIGGGINVLVQRQYKPLTPFWHGMPPPEERLIGSMIAGPILVIGAFWLGWTGNYPSVPWYVPALSLIPIGMSFTLVFISLLSYIVDCYTVYAASALAANTIIRSAVGAAFPLFTRQMFTGLGVNWAASLLGFVALALTPFPYIFFVYGAKIRQWSKFAPAHDLKIRKQLEEEGKLPKDSLNSTSLMNRNGVTEAKKAAAAKSDPEKTQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT48</accession>
    <name>W3VT48_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome c oxidase assembly protein COX11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02306</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT48"/>
    <dbReference type="HOGENOM" id="CLU_394366_0_0_1"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="77372" checksum="2297899BEF5B3B35" modified="2014-03-19" version="1">MLGRSVARAGSVALASAGRSQLVGVPMRAPATSPLLRLAHGWAREASLPARSPICARIGVSSFSTSSRAFATPRPTPGPSPIGAAGSRASRAASMTEEMQRRQRESYKRRNQSLLMYSAALMMFTLGFSYAAVPLYRAFCSATGFSGTPITDPERFAPSRLVPAYTDPSTNAPTKRIRVTFNADASDAIPWSFTPQQKEIYVLPGETALAFYTAKNKSTKDIIGIATYNVSPDRIAPYFAKVECFCFEEQKLLAGEEVDLPVFFFIDSDVLDDPSTKGVDDVVLSYTFFSARRNPKNGQLEPDTDLSHAASPPRLHSSQPSDLGHQLLHLYPTAHHTEEAPYTHPYPHPYLHFDQLCSQRHRHRHPQRPFRPIMAGSSLRNAVQRRNHKERSQPVGRAKLGLLEKHKDYVLRAKDHHKKRDMLKRLTEKAAMRNKDEFYFGMINSSTRNGVHQHARPSEQLDNDVVALLKTQDVGYIRAALLAEKKRIHGLVERIAPSIPNLPVEWLDEKDNRRPTLERAGLIAAPGKAKKSAVAKIGAQGKKTVWLDDADALRTYTAPSASTSGTLSTPTTPRKESSWVDELSDSSDIEVEADDLTTPNTALRKGNKHLGYLTTELASRYARLDQLQTAAEKLNLVRALMTHKGGHSSVVTARKNSLADKVARGTMTKNGLALTEEEDDEEGATTAKKVYKFSKERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTE2</accession>
    <name>W3VTE2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTE2"/>
    <dbReference type="HOGENOM" id="CLU_380806_0_0_1"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42106">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="728" mass="74179" checksum="9E394B5619D9F6EA" modified="2014-03-19" version="1">MNGNEAHNASPASSSSGLANRATFATSSTDFALPFGATRGSSSSSASNHAPSWAPGSSSGPISIPTRPFPTSNAGASSSTQPPLLSLGHLASSPSRFASSATGLGIGMLPSPSARDQSNALAQPHPSTLYAQPASPTLSLAGEGWPPPPATALSSASTTSPGGAPASAALLRRSQGMNSPGFAIASPARFRRASMLGREITPFHLDTDDRSDGERQAKSRAEPNPDDGDDEMMQVEDEDVTVSRAPSTPVMGPPLSLANTPSTPPHAHAVFRHSTASSALARASASDSGHDSSSSASGATSALGALGASTSSMTRAVPQSPSTGPSMGSPLGHGNRSRSSSLLSSNVVRKAVTRRGNLLPRDRSVLRVAASLQDESKPEDSEIASEAKLQKRLGGEATLPRTPRFGPSGSVAFGGSGTRVPKSPSDAPAAPGFGTGSSRRKYMWDDDVDDIRGVFCADGLDDDSSDLTEDEEEMMMYYSRTASVSDDDEAPRPGATPIRDADAAGDAAMGDASAEAGAGAGASTSVGTAVSSSLPKRKGNALWMGFRDKSNVHKWSPSTPASDRTWRRAEDTSPRVLNTGTRLSKRKTEDRYEPYKRRAVSPMNLGTSYTSAQAGAGAGSNSPLMMPISSPSGLVYRGIHQAQLAYARYSTSPTISRPCTPVGGNAAAGAAGAVAMGGFSPAASGSGPGYGSGALGLSISANNANVDARAGEELDAVMDQRVGMLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTM9</accession>
    <name>W3VTM9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTM9"/>
    <dbReference type="HOGENOM" id="CLU_070882_1_0_1"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="200" mass="21572" checksum="11F87C5084202492" modified="2014-03-19" version="1">MEAQSDLPSVAYDKEAVYTALTDFDESDPEFQAGIQTIIGPMQSSGVAPTQIEETKKRAKVFFWSQKTGNQVDYADYTAWLANKSTAASQINGATTEEFAEPTSGTTEAAAVEEAKATDKEPYPASFDAIVELITTGKTDQIPGIRDIPLKINEEPPTQPTMDRPLKPWEKAGVSTDEIPSTTATSNDAEATQYIGHASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTP4</accession>
    <name>W3VTP4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTP4"/>
    <dbReference type="HOGENOM" id="CLU_010916_1_0_1"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="561" mass="60940" checksum="5379A59460C583DD" modified="2014-03-19" version="1">MSHETSETSAADAVASTGAPVEAGPSTSKPKPNHSKPAAHHRGRHSHPARLTSEQLRRRLHFIESNSTVILKMPSGRTKAAEIVPGKQVSLGKFGSFRADDLIGMPYGFTYEIHADPSAAAVAEGAAQSNGQKKGKAGANAAPTGSLKLVVNRTLGDLETEASEAVETKATNEHINDDGSAQKLTYVDIQELKKQGLSGREIIEQQLAGSESFANRTVYSQAKYVARKEQKHLKLFTPLQPDFGNVCDFWFEKSADKIRYIRRDALSQMLSFGSVRPGGRYLVVDGVSGLLVGSVLERIGGDGTVVAINDAESPPAFDILPYFNFAPEVTRNVLKVVHWAATERDYAPVFSQQDVSSTAGEGGARAGKADKSRARKRQANFREVDRVRTDFFAGDFDAVLIACHYDPVSILNRLKPHLGGSASIVVHSPYVQPLVEAHATLRSDEEFINISVTEPWLRKYQVLPGRTHPEMTTSSTAGFILHAIRVFGEAQAVQMRAEYLAALESQKHADADHEQAAQGAKRAQPQDEAADQEQPETKRVKVDETVPAQADASMQDAQDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTU1</accession>
    <name>W3VTU1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTU1"/>
    <dbReference type="HOGENOM" id="CLU_141199_1_0_1"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="92" mass="10229" checksum="8CB471FB80C7C253" modified="2014-03-19" version="1">MSKRTVKVGITGKYGTRYGASLRRQIKKIEISQHSKYTCTFCGKDSVKRKAVGIWECRACKKVMAGGAWTLSTSAAATVRSTIRRLRELTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTW8</accession>
    <name>W3VTW8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tetracycline efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTW8"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="83"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="658"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="693" mass="73842" checksum="2EB000FA752B7AEC" modified="2014-03-19" version="1">MVQSTTPPASSPPTPMPTSSSPPIPPAHASSTHSLERTASHDDHLHDDDTTAAPTPESATEHRVKVALQDQTNFLPRNQVILVFAGLSAALLVALLDQSIISTALGTITASFHAGNESSWLSTSYLLTSTASSPLYGRFSDIFGRKACIIFALTGFLIGSALCAAAQSITQLIVFRAFAGAFGGGIVSLVMVVVGDVVSLRERGTYQGLLGVVVALSNSGGPLIGGALASVGWRWCFILAVPIALIALVSVILLLPLKKVDGSVKSKLAKVDYLGTALVLAATVLLLLGLNWGGQQYAWSSPHVLVTLILGAVIFVVFGLVEAYVAPLPLVPMRLFAIGTVSSVLVQTLCSGGIFFLLLFFVPQFTQVVKGYSGVKAGVTLIPLMAVQAVMSTVAGIVVSKTGRYKAIIVVGFAIFSVGVGLLSLLDEHSNIGEVIGFLMLAGFGAGGTLQVTLVAAQNAVHRRDLAVVTSTRNFMRLFGGTLCLAISYTILNNSVRSGARGVPADVVAAAVRNPKLITSGEWDAGVSEQLLRAYVLAFRNVFRFGLGLTLLAFVVTLLFTKEFSLDRGDDERRKEEGKQWYREKKERRQARKDQSAPHSTRHSHESHARQGERDVDVEKGILVFVTSLSTPPTSTQVGKSSIDWNKGEVKLRTSMRPVTQQDLLEQAEQKGQQGGMFVSQHAQSFSFGKKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTY0</accession>
    <name>W3VTY0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTY0"/>
    <dbReference type="HOGENOM" id="CLU_994417_0_0_1"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22014">
        <property type="entry name" value="HMG-box_CMB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000085">
        <property type="entry name" value="Chromatin-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000060">
        <property type="entry name" value="Transcription factor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="94"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="208"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="94"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="208"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="280" mass="30723" checksum="DEF2613EA2D43304" modified="2014-03-19" version="1">MRTAVRNAPAAAAGRNAVPAAAANFATAAPKETKKRASSTTTKAKAGTSKASAASAAAAAEKKPKAKAPKKEKLKPWQARGADGKLLPLPSASKPTLRSSFLIYMSERVSQLKGEPQYQKTSPKTGAQVVDIVKMAKAVGAEWAQLPPNQKARYEAQHEQEKEEYERALAEWKAALSPDDIKRQNAYIASQKKKGIKGTAFLRDPAKPKRPNSAFFEFLNDLRASESVIPNITEFSKRGGERWKQMTPDQKAPYEQRALQALEQYKRDLEVYNSTRGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTY7</accession>
    <name>W3VTY7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTY7"/>
    <dbReference type="HOGENOM" id="CLU_281064_0_0_1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="862"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1120" mass="122384" checksum="21AB2067E7799102" modified="2014-03-19" version="1">MADTPNRNGEDSKPVLVPYKRSQRPSWSCTECARRKIKCDKKVPCQSCVKRGRAEQCRLEGSPLESAGPSSLRGLKTPEEQSDDGRPAEESPLPSGSLRRFSNGAGAPAEPRLGGLDDTLFRGLSRLQQQLDRIERRLEYQSKQDDSIEDVKARLNDVEDVISALGERRDAWKETASDLIPPNAAMYSDRTANDLRRSDRPAASSTQSGKLDGVARNPSEGATSLARGANIRMPVTEPQERNAELASTDAATTLEFLTLGKDRRRDLDFDASSSDTDADASHPYPLETTADASQRPMFSSSGIVHTHQAGKDGRMLAADGNLDPGLRMLKHLRRGLPSFVVAQIEALLRSHPDELPPANLLARPAIKPVTDGIKAAKLSPSAIRGIVGIAKEIGAWQHCCVHFPTFEREVEAFLAIAVSGSLKGQGSDFEGFRAIDPAWLSLFYVLCSIAVHQMSEEEGSHCGVGAEVERMQLASIMLHAAMESLSLADYLVKPSAYCCQTIAILCVAGHNICGSDLLTSLLAIGIKTGQTLGLHALGRSARFLEACAAQRSQVLKRAGIQCDDSGSCRLPDESPRQFAIWRKRIIDLEVGKRVWWAFTQQDYFAIPFSGCFSIVEGQYDTPLPHNCSDEDLEEGRLINREVNVLTVASKQRFTCHVAKIVCDFFEDLNKARGVPSLSLVRHHEARLRFVTDRFKACLDPTRSASGPGSHGSLPSFTTVLQHYLFISVQHKILVMHRAFLSRDVSEHEREQSHSASIETARAVLHELERGLGLNADDDDRPQLDLQSRVHGGALWTIPYHSVAAATILALDMFKPASHAPHRAKRRHEVKRALEALGRFTRKSAIARRGCQLLADLLEEGERYDQRPRESRKRKATDGVDSVLKRIRLPEGEGDSPQMPDAESRTDMPSSARSPQEHAVNPALAHARTEKALEASWFSHFNHASVRSDVSSALAEGTSPDAERGGLLPAASFGYGSSNFNPLAGNSTSRAGKNASFHPSDATNSLSSMFMSYASPGGINDPFSALNGHRTTNGEDGRGPARRLDLPVTGDFSSPMPTWPTNQPDASLENGMQGNIPGMNLNMPQQQLAHILPALESMPDVWKLFDGTLGQNLVAFEESGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUJ9</accession>
    <name>W3VUJ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUJ9"/>
    <dbReference type="HOGENOM" id="CLU_071681_3_2_1"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000008">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="145" mass="16218" checksum="0E6112D62A212331" modified="2014-03-19" version="1">MTTEADPTAAPAGNVGASEMDAKLRQENQAAFSRDLEFVSSLANPFYLNHLALSGVLASPSFLRYLKHLDYFRHPRYVKYLQYPHALHMLDLLQSEPDFRLACRDPAFVGEVMAKQVAHWATWRDPDANAADEPPESNPLSTESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUN4</accession>
    <name>W3VUN4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUN4"/>
    <dbReference type="HOGENOM" id="CLU_1907579_0_0_1"/>
    <dbReference type="OrthoDB" id="10684376at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="133" mass="14758" checksum="48CBBB12D6E55FDA" modified="2014-03-19" version="1">MRTRYINPTSAEGIAVVGVCSVNRGNGRVEARSSQGTDRQAASPSHRNAYAQANHRVQTTLMTPHIFLPSPCPSPPQWRARRYHAKQHKDILGHNTPTLAYSRIGPSLNRTQPQSEPQSEPQSEKAQPRQSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUR9</accession>
    <name>W3VUR9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250087_0_0_1"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1455"/>
            <end position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1473" mass="148517" checksum="FD09E525E03775AB" modified="2014-03-19" version="1">MTAATAPSPSPAPSSAPPPLAHTPPTRQSSNDAIHASTDASATRRHDPSTSASPAIVNAAAAVDFASTNLGTLAKPIDLASPPGSPTIAPATAAAVASQSTRPPSQSSVSLPRATNAAQPSSATAPASVTPFANVNATPTRVLPPTPLGNAPDRAAATPSATPSASASKQIHLPSPYKAPRLAQAGASESFATAYPTQETRQKYASPSKPLLSATGNGAATLSHKRSWQSPLSVDLANKKLRPTPAPSSARSTSTSAASAASAATSPASSNPALSSSASAITTARPLSTLPVTARATNTASGITVTNIPKPGSPLSRQAGVGPLNLVPAVPGTQLPASTRDEYLSLLHKSELIDLVKQLERQLHDLIVAPIGSSALYRQARIYPNHIHTQIDRLKARQRIESSRPTSTSDLSLKDVYSLLNSGTSTSSAAASIYARTRAPQPRSATSTPTAVAQSTPSDAAQNASLTNLINSINAMVRQQAQPARGPNGAPLPPALSGASASALRTGVSAPAKARQPSIAPPSLPAAALRSIVGDGPMPSNAALAAAIAAHFGGSLPGSAAATTRATPSPTPASTPARRIGASESRGAIARTQTTSNDRNPPVTTASPTPAPGKDISDKIAAILGSSSSAHTTMLGPQGLPLAPAAAAPASASTPAALPIGNIAAMLSSLAGQDKESNLSASTNNAQSTSGMPAAEGQGGALASLLQQLEEAKKRLSPQAGPSQTAATPASSSSSAAAALSDPIAILTGASANPVFTPTYPAGTATSLSPGMASHRDASWSPEPEPVIVQGPLGTSTLPSYEDMIVEGLRIMGEAPPRTLFNWMQVTYPLTKKFRPSAHQALQKAFKRGRLLKTGSMYRINSSWSSPGESRKPTRRPQVGRDHPMVTPGLNGEVLAVSPLKDSQAYRNVGDSGLRPTGKGARAGPRPYGQPGAAPLANPASSIFQNGSAASIILEYQKRTAKKLDADSVKQLYQLIRSGPSDGPAEEMLAYLLTQTGYHDAAATATAAAAAQSAAATMPQYVRPHASMSAVAASPVAPGRMGVAGGTNATQRRLPVAKGPTSLPLPTTSEPTMMQQLASMLNDLSSPINPVLANSLLGQLSSNAAAAAAARAANMPAMGASGTLPAAPPRATVPTSSAATSASSQLASALSSLAGTASQQDLDSAVSQTLAAALQQIESAPNTASKPAVADEAAAPQPAETEGQAAASVAGEGDEARELEEGIDLAEYEDAIRALTSAFGGADEGDSEESDNEADERAIAAAEAEPDSLPEAGVEGHADEPMAAEGGSAKASSTAADPPAKGPEGMANSAGEPAEEEDEEEDEEGDAEEMDLSAVLQQLTASLQAHQESEAEAQGGDVGQGQDEGSAAAAGAESDAGVGDLPDRSTQPEAMEVDRDSASAREQVDEDGAPDGAQAVRDAAEEQVEGGDSDDRDAASLQAQLEALVASLAANAGNADDDDEEDEDEEELDEQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUW8</accession>
    <name>W3VUW8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUW8"/>
    <dbReference type="HOGENOM" id="CLU_088621_1_2_1"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="262" mass="29162" checksum="CFCECD4F4B70893F" modified="2014-03-19" version="1">MASVQQKIFRTANAPTGPADEVETVVAQALIDLESNVSELKAELRPLQISCAKEIEVKGGKKAIVIFVPMPQLKAFHKIQQRDRIPALAEEAVVAVRGDAKQYSMDYEAGQVARLESGSHALVWLPLLLQITSGANTDPCSGRSLLFHSLTRELEKKFSDRHVVFVGQRRILGKPSRKNRNQQPRPHSRTLTAVHESILEDLVYPSEITGKRTRVATDGSRLVKCFLDSKDATSLEYKLDSFSSIYKKLTGRDVSFQFSSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV55</accession>
    <name>W3VV55_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV55"/>
    <dbReference type="HOGENOM" id="CLU_612808_0_0_1"/>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="160"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="408" mass="42418" checksum="E1478ABE76EE50B7" modified="2014-03-19" version="1">MSHLKSDYFGSDSASGASSGGTSPAVSAMLSPGSSSVATSQLSLLAFESQRNSPSTSACTSVSDLSSEVDKLSLSPAVPARHTTKTDSAPAHALGAGEEAESSEDSEAAAVEAENRRVEEELDSALAFGAQIVQREARALAMAARRLSRYSAQQDGFRQAVRLVLRATTGERGGKVVLTGVGKSGIIAKKLSATFLSLGTPSMFLHPTEALHGDLGLLTPHRDVVIALSHSGSSPEILALVPHLNMRRCPIIALVGKRDSALVKASDAWIDCATGKDDPDSESEEEYEVAGDDVEAHSIQRSTAAQCDSCAGGKQRAVRTSQRAPRPTTDEAWDDVPAPSSSTTVALAMGDALAFSVTRAKGLGRDMFAFNHPGGKLGADFRLQGQSVPLQSYDPKGTESAVATPIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVG6</accession>
    <name>W3VVG6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVG6"/>
    <dbReference type="HOGENOM" id="CLU_790163_0_0_1"/>
    <dbReference type="OrthoDB" id="10606482at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="351" mass="37372" checksum="CE78C51BC5096678" modified="2014-03-19" version="1">MSRAVSSSRFRKANPNRNTSFCPFVLVQHRKQHCDLPEILQITGCTRDGLSRQAPLGGSVLRSDTVYVLLVVVILRTGAQKLQEQGGKVRDAQIGVADTIAERLLRASATFGRLPGKHDDAVDPLAALPHCRTAAWDRGRPGSASVDADGHAELGGMGKVGSDGQSKFVALLVLTKGSKFGADVPRQVNDSAAERHADLHATDVDSGSDADVARLAATRIDFSSDSELAGGEAEEGKKKNKLLPSWQVSRRCLQLLRRLLRVGSLAGGSASPIDRRVVHAVLACQHWHPAPRNAGLHWQTCWRADGEPSGALPLLACAAAAARALLDRCRLPMHARPRGSVLGTAAARSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVJ8</accession>
    <name>W3VVJ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-hydroxy-3-oxopropionate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVJ8"/>
    <dbReference type="HOGENOM" id="CLU_035117_5_2_1"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="3">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="4">
        <location>
            <begin position="218"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39046" checksum="12883731B807617E" modified="2014-03-19" version="1">MASHSNLSAAVNADIPYSTPSTPHPQHQVGWIGLGNMGVKMAANLAKHMREMSPPLPPLLVYNRTASKAQALEKELNGLVRAVDSIEAIGSQCDLIFTSLSDDEAAEHVYDALLQAEEKRVGKHTQERISSGFSTLLIDTSTLYPATTGKIERKISALPKRHFVAAPAFGPPPMAASAKLVFAVAGPYNSKKFASQFLVPAMGRKIMDFGSNPERAASFKLIGNSIIVSTIEMLSETMTLADKTGVGSDRVYEWLEEFFPAPSALGYGKKILDSNFQGENGFTLNGGIKDASHIIKLGESVDCPLPIIELARQHMVSARAIGGANLDWSSLSAGFRVTAGVEPFEKKEMLKKWAQDERGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWR0</accession>
    <name>W3VWR0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWR0"/>
    <dbReference type="HOGENOM" id="CLU_078842_0_0_1"/>
    <dbReference type="OrthoDB" id="2520628at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="295" mass="30833" checksum="086C216F8571AB0D" modified="2014-03-19" version="1">MLAAVLAPLAAVNARLAQPVHATLYPFPLATTLHALRVALAYRGLCAAFTARRRAEGKAVAELRVSWLRDLAGFLVMAWGGSFLANHILGQIPGQLLAAWPWANYISVYLAVTFALSVAPAPSAKLLDLTLPVLDGATRTAATYGGINMVLNHANPAARNSLLLQVIVATVSACGGGISAFTLNVFDPLGWSLTTPPFLNATSLVQLTDIVAPALAAAVFGVLTLSHPSYASVLAHIHHKPAALLSHDGGKAVISLVIGSCFFVRAIWMHVLTPAPAPARPIAANKAIRSASKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWY1</accession>
    <name>W3VWY1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001970_0_0_1"/>
    <dbReference type="OrthoDB" id="2556125at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1697"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1733"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1592"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1624"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1703"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1766"/>
            <end position="1780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1780" mass="189451" checksum="3CAE3DF1B8FDB99B" modified="2014-03-19" version="1">MLSPTRRPRRSVSRPSINDENASPFPYSLDVSVSMQPSEPPSSPLISNSVLYNLPDPTIGLPASSRLVDLPFLPSPFKRSAIAPLNKPLSIEQTQQLGSIKPRSSSSASLQPSSQANLNAPGGLPTPPNSGEALIATPGPSSRALASLPREPVSPSPTRSRNVRPSPARTPGSRSSRAPSTPLRSQRGTPHRRLTSNNQDGSEDDDLNDARNTRTPSRMQPLREVAEDSDDEEPEQEDEIQLISFRRGGPDATFVREIKENGWDQPMPPSPIKFTYLEPVAPRPRQSSAALRARSQSRSKTPQIRASPAPSHASSSRSSRASRSVRAPSATLADQSADASDESIKSSGSVLTNLSRLSQTTAARASRRKSVARSSIPPPVPTADLTRDHPSLPDSPGDDPLLMTGPNTYILYHNQTPIAKHRGAPPPSGGLVQPSDRDDPSMALSTPIEPASSHRDRSSSAASSDRTSLYSRMSGRPAGDTSIQVANDDDDENHIAADLSIHAAGAPLSDADEQSHAGFMAHDDAGFDSDSDQGDFDAMQAHNTSAMLPHEEADGEDESIDVRGDISSMSDVSRSFADESAADVHGDITTALHEQDLAADASASSEQLSDVNTDHVDDDADDSSRPEDADTSIMAADLSVAIEEDDNARSAETSFDEQDVSIAAPDLSTSVEEAVDVQSAERSQDEQRANADASQSIVRNASTDGNIDALADASTDSNDAADESLVRDDALASVEASFDESRLEDAEDGVTADSEHVSKSVATDVTFDVSLVSDASARYALFPTHIDSALLPTPYVLIPSLADNGQVSSTADLSSLDTSAHQHGDGDVSMDAPESEAVSQADISVSVMQEDTADGSLSSELSSASLQSAHVQEQDDESFRRKYQARSDSTPEPSMARARRLSLSTDPESASDAEEDITDDDQEEDDEMEEANDANESSHHSSLSRDLGARSFESTNAQEHDESGDEQGSEQDELSASNESELSDDDASSLDDSSVDEEDDDDDDDAEEEQASEHGAERDVDEEEQDENDDASSTHSRVDDDESEQLDSVVILSSSASPSVSASHLIAPRDDDAEAENNSYVVSVVRDSRDRTRRASEHSMIDDEPHIHTLHLRQPVTSADATGSTMADASHSRSRVLKLGQATSTPIVEISSLDPRAAARATAILKLFHKYVDEGWISAGDMDATGASSATGERMRRVVDAIRRADTHGRLEDASALQHSLERADGTTSAAADLTTLLMDAELALARQGSADTESLLGSRAASVVSTRRLPTASPATPFLPGGFRATPAASNTRIDDTASPSPAAAPRSRANDSTIASATVSFPGLSTPDRRRRSTAKQARLSQALAAPAPDSFDARVWDTQDWVRLDKYFALGVQKISSRLLSSTSADAGADKMLRARCYMDALFDTDVGEVAWLFLAEMHIAHANQVGEWTHTKLTHRLEALRRKYARKIHRRYPDALQDARALGETGANDSLATEDLDWSVDTTAQGPVEARSGVQAAKGRVSFGTPYRMGAHSTPAVGLLKKATRRAARDAMQRSEPVYPALPDHEAGNADATEAEAEAEEGVMTRASRLISRLSGGFGGLLSSPRPEAPRPDKGKRKATEAELSPARVRRRVEADVSEDSASASSGDSYVESFLSTVPAVHRGLTTTINASMLTNATSVRPDASVRSRKRTTLGVGSQSLLAPASVIASARAGGTGWGSSRQLSGGSSGVSHTPLSLLSPATHRAAAKKVDELRQSRAQRNWTSPRRARLHRPTTLGTGAGDISSSSSGRDGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDF2</accession>
    <name>W3VDF2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDF2"/>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="59133" checksum="3EA65295D0E44018" modified="2014-03-19" version="1">MTDIRLVLSAAVAVVALIVVRAVVSRSTSARNLPPGPPPESWFTGNRIPSTHPWRTLEKWTRQFGDIYTLRIGSTYLFVLGQASSAHQIMDKQSGSSSDRPRQIMAGELISDNRRMLILPYGPRWRLFRKVMHETLQDKVAKLYEPIQQHEATIAMLHLGRTPDRFQQIFKRYAAAVIMQVTYDHHITSVDDPLIKDVEECLSDLAYWIRPGTSLLDRYPPLLYLPTLINPWKRKGLELRAREQKLFMSQWDAVRSRVKTNQCQPCFVSKVQERQHELGITDAEGSSMAGSLFGAGSDTTASGLAIFVMAMCKFPAVLRKLQDEIDGVCGGDRCMPTFADLTPEQTPYLHAVVQETLRWRPISAGGFQHKLTQDVEYRGFLLPKGSSVVAPHWSISLDEKEYPDPHVFRPERFLRGDEGELKVKGTWFAAQRGSVAFGFGRRICPGLHVAMRSLLINLAAMAWCFDIAHPSGRPDNVDDLAFNSAANSHPLPFEANFTFRSPAREKVVHDENRATGELARLANRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDH1</accession>
    <name>W3VDH1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_06512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDH1"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="25"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS59589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="387" mass="41291" checksum="8284AB9D5C5DBF93" modified="2014-03-19" version="1">MSAQVAPNNSLATTPAEGNVSFVLQEIEKVSFEDRPVVAPKRGQVQVNIRQTGLCASDCHYLHHGRIGDFVVRKPMVLGHESSGIVTAVGEGVTTHKVGDRVALEPGVPCGGCHSCLQGSYNHCPDLEFAATPPYDGTLCTYYNIMAPFAHHVPDTMSLEEASLMEPLSVAVYSAAIRGQVKAMENVLVFGAGPIGLLNAAVCKAYSAKRVVVVDVVDSKLEFAKGFCATSTFKPSLPKEGEAKIDSANRNAQDLIKSIGDDVGAHEGFDLVLECTGAEPCIQMGIQALRPKGRFVQVGMGRSEVEFPITRVCVKEIDVTGSFRYGAGAYKTSISLVSTGLIDVTKMVTHRFLFKDAIKAFDTTTKGVGEDGKTAIKVQISQGEGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDS6</accession>
    <name>W3VDS6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_230911_0_0_1"/>
    <dbReference type="OrthoDB" id="3259825at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1280"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1735"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1820"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1478"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1617"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1752"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1777"/>
            <end position="1786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2047" mass="214034" checksum="4521D40187049436" modified="2014-03-19" version="1">MINPFKKRQQRKAVAAAAASNQGGPTDYGAFPSSSKLPPRPGLFIAAASAAPGSPRSPHSPRQQRGMQVGQLQSPQLAQQPSLDHVLPPTSDFRQSLIMPHLTRRFTLLRAPDGSLVTPDAMRAHLRAQRARARAANLAIGSGIANDIHFLTEDEENAIIEQLKAQARAEGRDFDLEQAVASATVDSWRNGYAAGTDGFGSWGTSLPNTAPQLSSLTESLGDLSNSYDRATTASASTASPAWSPFRKPGGSSFTGRSSDRDHAHFRNAQRKRSNSKSDGTTASKQAHTPVVAVDEAASQPTSTDASAASASTACDSPSSTSLLQVPGPASASRSSSTQDSNLLTTLSPEAFKRVSTALDEVFAQIASQNGSSPARTNVTLSSHQAQRSSVDSDANSFTSALSNVRAADNRLAPSGAASADTASEDEDAADTTITAPGPTLDAVHIEQGGLAMSSPIRDLTLSSSPVPDTMPGALPGGHADFLPDLPESQTATQLPALVASDSALTVTDAAKGAEPTTQSLAPPNGADGADHLQVSPALTYLSLRNSTATATEVPSQASRIVSSASTIDAHRPGVADPSPDANVSVSTEEPVVRPTSEANRSSLSGQAHPTEGADNTRRSFRTPEMSNANMFAGSPAYSTLSRGDSVVSANSGRSSLAGPPASNYSSSHSRKSSVDKLALARSVAPHPSLREQPSLSSVRRNYRQHVRSATGSSEGSLLGTHASRRSSGAMSPPPMLSRSARSPNYFPPPASSAPMHDYASGFKPPSAVSPAAAAALQAMAGQANHSPQPATNSVTDASNALRSVQSMRNSASTSQSAASPQVPSMGAFGSGSDRAAVPSSPETGSTSFSLHQRNTSLSSSKQNRHTQTSRISSTDEGFAAPRPAPVPGAIASQPTQPSAAQTHFNEQGLMPNPPSEPEQAERWRAMYGIKATDAASLRASSEDVSADPNEEEDLWAKMASGSDPTGADRPVSSLPAGTADERLAGTGITVDQIARFQDHLIQSADENETVPPLPRLQADDNLKERRFAEAKSKGLASPNLVIGTGSEWSNPSSREQRAGNGLAFGPSSGRPTVASPGAPLARQPSSSFSHDPPVSPRAVMYDVTTSHRPTSPPLHSRNGSLNGLPSLLELNGSVGPRNRESFSLSHAVDQASRLHQQSMFTSPSVAEEPAGSDQDSQAVLPSPPVQQHPFNAGYTSPMLPAADSRGVQNFTFPRKTVTEDIGASPRSQAKQFPPEDVWNRYGPQQDSSPDTSFGTDHAMPQLMGSDPTRLLDDVAAQTSAATRALKGTDDGSMPTPPFRTKSISRKKSFKKVSKQISSPQLISTTQRLDHANQIALPPETPAALSKTSKRSNRSPGWGSLGQGALDGSRGHPKASPSSASQGGSVSKGSGYFHRRRSSSFGHEASPSDSFGIKGGADGAAAEQINGERASVHPNHPYMHGGANGGSLSRLFSKIKSRKNGDQAFGGATIEPFPPQLNAARAAETAPQPPQQLQAPTPVLPPLPLERTTPWTLSSVSSPKSVSSDRGSSLRSPTSPVYTLPIDSTSMPRSKSKKRTPIVLKRESEVVLPGDAAYMPTAIIGRSPEQRARDLAAMPQPAPPISLPMEVGEANAAQTAPQEASPGGQEAEAQEAAATNEEHVAAAAEDAPAGLAAEVAGDEMRTPRPPSSWNGEAVEAEDGDTTLPAAAAAAAASAPAEDGERSVANARKSLRDTIVRRTIIVPAGLELGDYRRSMFGSSRKSRRFAAEDEPLPSAGAGDTSTAADTTAMPAGGVEEAMSTLSSRQTLHPDSGTAEGSKRASRVESSYAGSLYDMYAGDDIEFGSPGSETRELARRSMAPGATRRHIEVTERADGSVVWQVIAGLAERGSVYSDLDPRHSRHNSDASAANLATLDAAADANEWRTPAGLTADDSRSFFTRPQGGHKKSFSFDAMPPLPTSVQQEVFEIANPAPQDAQEEVEKKAEPTTIVYHNDAQLASLLDVLAKGKDSAKFEFHLGPDGPDYPLASSADDQPVIGDVVDADDIELHRNRVEAEIYTLLNQHALRAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEI0</accession>
    <name>W3VEI0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEI0"/>
    <dbReference type="HOGENOM" id="CLU_120772_1_1_1"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="126" mass="13043" checksum="8FF107C19DBAA8D6" modified="2014-03-19" version="1">MSWQGYVDNNLVGTGKITQAAIIGLKGGVWATSADFNVTAEEQKAIIAGFDDPSGLQAGGVRANGKKYFTLGVTPKTIYGKQGADGFVAVKTNQAVLVCVYIAPIIPGDANKVAEGLGDYLVSVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEL3</accession>
    <name>W3VEL3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEL3"/>
    <dbReference type="HOGENOM" id="CLU_1548274_0_0_1"/>
    <dbReference type="OrthoDB" id="2556695at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832989" evidence="2">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="173" mass="18407" checksum="0CF006104D403837" modified="2014-03-19" version="1">MVSAYALLAFIGAAVLPFVAADGDRVTVLQPCGDAEHATAHAIVPDAGCQKISDSGSFSLLALNMDKHTKLGFSATPDCKLTYTPSYDDLAKLMAGARCNTYVTGSKQASDSDKDAKDSRAQQQDGSPTEANRMHKRRADSIDASKLKQLSAAENQQVPLNYVMLVQPQDTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VET0</accession>
    <name>W3VET0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exosome non-catalytic core component involved in 3 -5 rna processing and degradation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VET0"/>
    <dbReference type="HOGENOM" id="CLU_063514_2_0_1"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="348" mass="36695" checksum="2374C3A38ABC45B1" modified="2014-03-19" version="1">MAPSIAKATAGSSSTSRFTASTVKRTSPTALRPLSAEVGLLARSDASASFSFGALNVVASVSGPTEVRVRDELTDRATLDVVFQPQHGVAGIPSQAVSDSLLTALSSVLLLHHHPRSLIQLVLQTLCSPSLPQSSEHTLPSDLASNQRYVPRQPLLLGPDAPPSVTEQAALINAASLALLDAGIPARGSVTACACAILPATQGTVLRQNSHLDEISESQLAGLVRQYKQENAQADMDEDEDDADAERANGATSKRYLGETIVLLDPTPVEIDYALSTHVFAFSFSQVLEGEGDEAKARQVSEQVLAESQGAVDLEDLGRARELCLTACSAVLDFMRATLTKRIASQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFC8</accession>
    <name>W3VFC8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFC8"/>
    <dbReference type="HOGENOM" id="CLU_1142465_0_0_1"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="3">
        <location>
            <begin position="118"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="242" mass="25871" checksum="50947BCDEB381B4D" modified="2014-03-19" version="1">MQPGTMQAGDTGPRGGRRAGIRYHSLQRTRAPRVVRGCGNDALADALANATRAARAASPKILSSAANVNHRLSLSLATIATHPIENIITITTTTIMASASAPGKWARVFKVSIYLKKKDGISDQQFSDYYAQTHAALAGPVLLRHNCISYTQFHHMTETARDSITSIFGPDALSPQNPMQPIAYDGCSSFVFASIDDARGFFHDPETAQILGPDSVNFTNTATLQVAIGDEFVAIQDGKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFE5</accession>
    <name>W3VFE5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFE5"/>
    <dbReference type="HOGENOM" id="CLU_778893_0_0_1"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834098" description="Protein YOP1" evidence="8">
        <location>
            <begin position="18"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="349" mass="37561" checksum="7259D865A90BDA21" modified="2014-03-19" version="1">MALLLLHLPTLALNATATLVYPLYSSYKAVTSSTTSLADMEVWLVYWSVFACWTLFESLFGWLWSWVPFYYEIRLIFNIWLVAPQTRGATYIYTTHLHPFLQSNQEQIDALIDDAKRSLKAKVDASLGGLWTASLGGSEQPTAPPAPGKEARHRPPGPGSTPAPPTQHNPAQAPASLFGNLLNRYAPVAIASAKNFLESKAAPPNTTMAYSIPPSGSGNVNDQRAREAAMVRRRQLESQLAALDASGVPSSTSSSSNSSDDDNTAAAAPVTMIHPKNPRSSFGAANAQGSLRSRIVSGGARPTVKAGTAMGESYDLLDQNDLGPHPQQSPRAKRSSWIPWSPNPNHPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFI8</accession>
    <name>W3VFI8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFI8"/>
    <dbReference type="HOGENOM" id="CLU_1042528_0_0_1"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30417" checksum="3C6996311F9D91B5" modified="2014-03-19" version="1">MNNKLSTSTTCARPGYITYLDERQRRGRRTVHAAALHRSSALHERRSRSGVASFDSAPICNSLRPFRISPSILDRSPAPLLQQTHPTQKHVTHCTVRPSAQHSNRAIRLTSPLVSTRRDDYDAAAAAELKRKRTFRKFTYRGIELDSLLDMTNEDFMQVVHARARRKFQRGLKRKPMGLIKRLRKAKAECQPNEKPAMVKTHLRDMIIVPEMIGSVVGIYTGRFFVNTEIKPEMVGHYLGEFAMTYIPTRHGAKGKGATVDRFLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFR4</accession>
    <name>W3VFR4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFR4"/>
    <dbReference type="HOGENOM" id="CLU_1807035_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="143" mass="15003" checksum="72689522A68A7D2E" modified="2014-03-19" version="1">MKREASEASAVEASGNRAVQAYPTLSSSPRLFPPSLSNHIVGPPPQRDFGSAHPTWTASDAHACFAAQMHGAWRRSDSTDSPSLPPSHTSPQLAIGPSVLAILPSSPTPSTPSTLVFVLGHPTSTQEPTSLFRLSPPSSQRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFX8</accession>
    <name>W3VFX8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFX8"/>
    <dbReference type="HOGENOM" id="CLU_021537_0_0_1"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="673"/>
            <end position="676"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="811" mass="83839" checksum="05CB6ADB6B74A0CA" modified="2014-03-19" version="1">MSGPMKSGRSDLTRRCGAGDFTEARGKGACGESEASLLDPIEPTDQTKAIASTPSSSRNHTTATPHPHISSIMLRRIASRTLREPIARPSSPGPQPVAATSAAVLSYQYQLLQQSRGLVSSVLLSSTRDAYETKKIAELKADLKSRGLASTGRKDDLIKRLVDHDSFVNGSTANITSIPSLRKKSTLASLRDGASKDASKDAKKADAPAPPAPTSQSGHAVVKGTPPSKDGGEPKGPIVDADTAKAVAEASKPLGSMKESETPANLEPGTVHNAAADGLAGDATAKASPSQPDEGPAKKTTPPGLPPHKAPQPKETFNVQIPYYPDAPVPGPEIPVVTSYTSPHLRQPASSTDNSPFMPKAISVSASSAISHASDMSEHSNSDDSSRQKGILAEILADLQASTGSDGDKQSALKGINKSVDAAKDAWSSVAEQAKGAFASAAGGESSSSSGSSGSSGSGSSSRRTNRPLNEQERSGAFVLAGIVVGGFVLGGLGKPSKAKDAKDAHHDSNSTQSHSTTEAKSVTVVPVAAIPKGDRARAEEDAKPTGSAVPVPAGSKVLAPVMCVPKGTQLSAGVDASAALARLAQLSTCEVSDAMLKLNLSGGGYLPGIEMYSPNGAESVRICGPAYTVRMVSQQDTSAPKPARHFVDSAEGHEGSVMVIAAPSLARSAVWGGLMTARAQYLGLQGVVVDGRCRDLAEHRDAGFAVFARGHSVQGQSPFTRPAQLQVPITISDPTITSEGDKFNPAPKEVTVRPGDLVLADQDGVVIVPPENVEEVVRLAEKGRAEDELCMRDIRAGMPVQQAFAKNRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFZ2</accession>
    <name>W3VFZ2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFZ2"/>
    <dbReference type="HOGENOM" id="CLU_021165_1_0_1"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF96">
        <property type="entry name" value="BCDNA.GH08385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="536" mass="58470" checksum="596E4342DEF8BF7E" modified="2014-03-19" version="1">MAPDAKSASTSSSAAGLAKYISKHPSFRDPRSHASPLPALYADLSRQRKSNPAGYRASIEWWKDTLLDVTWQGVQLDRDPPALDPSSLDSLNEDVPSASSSAPLPDRTVFRLDESTKARWTVEGVGRPLGLGSVIAELERAHTVTPLSKFLHCSTPLHGPAKPASGLRGYLPTPGGVASALLVTPARWAASSVLGMVTGSAADDDYSEDERLFRDKRGDWVVYDLVHRIASAFLLHHFEHDATLSPISALMTAAEFRQRLARVCASQFGFHPSERDVQLVLTHLSRDCGGVLTTSGGIIKLAGSEAEVAERISEEDRGVVAVKETVRKVELQITSLEAQMGRRTVQAKEALRKGNKAQAASYVRSRRALDEVLTKRMGARETMTRVLIGIEQAKSDVEIVRAYQTSNEVMHNLLAKPELNIDSVDRTVEALEQSLASQREVDDAIRATAASDVDEDEIQQELQQLLDEKSAQSKAEAPPKEDAQVTQEPQLAAKPQDTTDDDLIARFNQLRLPPTTDPAQSTPTTPTQDRSEPISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGJ9</accession>
    <name>W3VGJ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGJ9"/>
    <dbReference type="HOGENOM" id="CLU_536345_0_0_1"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="65"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="530" mass="58874" checksum="4088729261FFC1AD" modified="2014-03-19" version="1">MVLSMSRNTARLLTVNLAAPTRATWRPLGYSSMRALRACPCSSAVPRCEPSTARSAAGNEEAEVEWISFAGRTVARSGLEEGETLLEAARAKGVELEGACDGNLACSTCHVVLEERIFGMLDRPSDQESDLLDLAHGLERCRDQPRRSLVERRRVSCQARLSHRTSTRNAPLQAARSAASSSSIRSIRSLSRGFQPSLAMSAGPSEAAEAQSVTSMQAIWEQDADLAICTTCGNQYPSVQGPQECPVCYDDRQYPCPTGQAYTSPRELAGKTSFELVPEPEDERIIRVKLEPPVAIGQTPFILLTAQGVVVWDCCGFVSVDLMRRIQQQSPTGRVLAIFISHPHFFGTSLTWAKLLDCKVFISKPDRLWYQRGLESAQPHPDIAARKKFVVEVDQDTFTLPHLPSITLVRCGGHFPGSNVLHWDRDADAPEEQARRGAAVLCADTFMVMPDRKRFTFAYSFPNNIPLPPHDVERIWTQMRSFNWSATYGGWPGRHILTDSRATLLRCARYYVQMEGHSSEAFQELREARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGR3</accession>
    <name>W3VGR3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGR3"/>
    <dbReference type="HOGENOM" id="CLU_066963_3_0_1"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832968" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="224" mass="24995" checksum="AC01FF8204589922" modified="2014-03-19" version="1">MLSSPLRTARLLLLLIAVLSSTLVQAIKFDLPAATHPHTKCIWNYALSDSLVIITANTIAKEPFDFSNQRLDVEVVDGSKHNNVYLSKKNIKGETRLAINTHSHADLGVCFKNTQTSKSSTAPVVTIDLDVDIGADAVDYNAIANQESLSGLETEMRKLEAVANEIVNEMEYLKKRELRMADTNLSTNMRVTNFAILTLVALIALGFWQVFHLRGFFKRKYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGS0</accession>
    <name>W3VGS0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGS0"/>
    <dbReference type="HOGENOM" id="CLU_035839_0_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="49"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="431" mass="46730" checksum="1FEB7539B910B1D4" modified="2014-03-19" version="1">MASTSTRRLVGGTCTVDVTSGLVAHSDGLSSRIYRWPLVSSPSFPYARSPPSSSYIQGLEGLALAAERAGGVRGWTCIKRVHIDEEPRPHSVRRELALLSTLPAHENIVPLLSAFCDTTDPFGEFVDLIMPLYAATLEDVLQEPSLLRLPCQGSMERAGGSIRHLWEDSPAAFAHSVALQMLSGLAFLHGKEVAHRDVKPANVLIAHTGAVKLCDLGTAFSPSSAGEEEQKMVCQVGTGIFRAPELLFSPSQYDAYAVDVWATAVTLAHFHTPLIPTLTTPVAEVEVDERTPWQRAFDSNTEPPSPGSDQLVFWEEEPRMPQQSASGYIRTPLFEPDRGDIGLAASIFNLLGLPTDLKDWPEAEHFHPPLHRLPFTPTQATGIQSALPLATNPNPLVDSLIKPALHLSASHRPTAAQLLTSLPSPHTPAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHB2</accession>
    <name>W3VHB2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHB2"/>
    <dbReference type="HOGENOM" id="CLU_2400623_0_0_1"/>
    <dbReference type="OrthoDB" id="10551774at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="93" mass="10305" checksum="ED8FF5E2B297A2CF" modified="2014-03-19" version="1">MRASKPILLANAQLRIKLAWFEIGSGALLPFRTGYLRPANWHLALQLFMLSPHFASVAQSDYVGSEFDNVTSQASCVSKMRMSTKVEAPPHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHG4</accession>
    <name>W3VHG4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHG4"/>
    <dbReference type="HOGENOM" id="CLU_025360_1_2_1"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="594"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="624" mass="67333" checksum="4A7B5CD5474D8F68" modified="2014-03-19" version="1">MRPKQRPPLRSHSNTHTRNAAPSKVGRESEGSVDHDNQRAPVRTIVRLHIVLLACLQPDPLSAADDQSNADSPAARRDIFRPLDKVRSAIAISAQRTGLAAIPSSHPARNQSFSPGVNSLRSGLRCCHHLRSLHSPLHPERHQGLPHLPFQLAVKMASGNRSFFAPQETRVDLPHGAATQTPDITRPASPSENDRAPFLNGGEGSREDVRMGAKALRHDADKPAVGVMALAPILSYCAASITMTVVNKFTVSGAGFNMNLLVLLIQSTVGVTCVMIAERAGLIQLRGLNSRDVWNWMPLSTMLVFVIWTGSKALQYLNISVYTIFKNLTIILIAYGEVLWFGGRVTRIVLSSFLLMVLSSIIAAWSDISNVFAIGNLSMPHTPDSIAGGMSKDPNTGALIPAFDPLKAEKDAIAAQIQGASANDVIEGFQGYGLLSSGYLWMALNCICSATYVLLMRKRIKVTGFKDWDTMFYNNFLSIPVLLVMSFLVEDWSAANLHKNFPDDKQTKLISAIVFSGACAILISYTTAWCIRATSSTTYSMVGALNKLPVALSGMVFFHDPPVTFSSVSAISVGFFAGLVYAVGKNKQAEAAKLAGTSASNGSSSSGSKDGSSLPMHNLNDRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI19</accession>
    <name>W3VI19_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI19"/>
    <dbReference type="HOGENOM" id="CLU_023751_4_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="714" mass="77999" checksum="4FC10FA6EA159AE3" modified="2014-03-19" version="1">MPPRRRASDPKRRQRVCLPGGAASPTHVGHARLANSTCTSARARAGPVVAPATAQAATSIRHELDLVRVVLPFPAAIVSVGHAPHPPPLHLLILILLLAVVACIQQRLGLDSRSFIADRLLVLASSSTPSLDRNNLLASFSSRFLDRLHAMPSITAKLKAGALASLALVALAQQASGSKPRLNRIDVDLHARDPSLHDNLPLFTDGLLDSLNHRLLPRQSQETQDSIRDQSAVDPIAAAQAADALPNVANNAAGGTDTTGNLLQGDGYSNFAWNQNVPFIPSAATNGSDETGWQELPDTPGFTLNRTFSVHNVFKNESGVMPFYISTVADPTKVLRAIVVWPGKPRDIWKYANLMLNARNVAVTNFNQQGVTNDSFVIVAPAMLNQLDLQAGAARPNEIVFHGSSWQRGAPSRNPPMKHAVTSYAAVDQIIDDLFNRTSYPNLNQVVVAGHSMGGQATQRYALMKKTKVYDNNVRFWIGNPGSWAWLTDARPYSNASCAAGNEYDTWPYGLNGNQTKLTSYARKDVIANKTYVIDRFLNRQVSYALALLDIGAGDTHCQARWQGGNHLDRGSQFVLQYQNASSFYLNGKFPPRHTLDYIANVSHQDYAMYSTNMSLQRLFYDGLMVRNADVANTTNPGDKKNSTRPKGAKAFATPAHEKVAIGLLAGSLGLLFIVFTALPIIFTADHVKDVDMSWDSQSYLSTESRRMLVDRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI31</accession>
    <name>W3VI31_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI31"/>
    <dbReference type="HOGENOM" id="CLU_1230367_0_0_1"/>
    <dbReference type="OrthoDB" id="3351759at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="226" mass="23695" checksum="154F5FEC168B0954" modified="2014-03-19" version="1">MAATRFVLAPLGGIFVATSLLYTFRHTIAVRTHDTAVALNRIQLQLNDIDPDNWDKEGKQRVSREQLKPAYVAPVRPTVTEEIKARWNEHLIGAVSTLANADYYELFSNGIVSAKNMVSKLGSSESANASVGAPLQAQVAATGGIKTGVINTQGVSLRDESSAAAAARDAVRGPGSSFGSRIARAVGLDAGKVEKVVEAKTGPGLGKVGDGSAGRTFYLGEGTSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIA8</accession>
    <name>W3VIA8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005967_0_0_1"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43049">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43049:SF1">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="924"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1094"/>
        </location>
    </feature>
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        <location>
            <begin position="1131"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1233"/>
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        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="298"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="429"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="571"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="607"/>
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        </location>
    </feature>
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        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="670"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="717"/>
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        </location>
    </feature>
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        <location>
            <begin position="843"/>
            <end position="855"/>
        </location>
    </feature>
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        <location>
            <begin position="924"/>
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        </location>
    </feature>
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        <location>
            <begin position="971"/>
            <end position="990"/>
        </location>
    </feature>
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        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
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        <location>
            <begin position="1045"/>
            <end position="1057"/>
        </location>
    </feature>
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        <location>
            <begin position="1082"/>
            <end position="1094"/>
        </location>
    </feature>
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        <location>
            <begin position="1144"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1370" mass="144944" checksum="E7173EFD3E548E96" modified="2014-03-19" version="1">MPKVTHTHAPLLARTQAHAQAHAQAHAKDTSILPPPSESTTIQAFIHRTKQPDISTSPFTLSPLRGRDAKMSEAQDKTNDAIEHVELDQDTEQDRGEDEIPSDELEFAADAEHADDGAVSIDGAQPESDRTSSEKEGGDPAVDEDAAPGSDRGSSEKESEDLTADDPVDELSADLPDSTSDSKLSAPSTPSAAAVRTAKVAATPASVRKPVGAAAASSTTGARRVVAGARPSVTGAAATRAGQTTAAGVSRPGVAARPSVAGRPSVTGGSTTAARTTATAASRPAVGTASTAVRSGVAARPGLAAGARPTTAVRPTATGAAARSAVSAARPTTTTASTATATGTRTTAAAVRPSAAATSTAAGAAARRVSAVPPSPARSTAGTSTATAARRPPVSSTAGTTIAAKRLSAAPSSASSGTAAPAAGAAARRASITSNSTSTTAARPASAARSSLASAARPTATSTAAAGAVRRSLAPAGATSTSAVKDLQEKVTKLEAELAEQSEQLDQMKSDLESKDEELQAKTVSLSAAEAKLAGSDEASTEALSSQARVQELEEQVKTLEAKLSSSADEQAEHGADHKATLAEKDALVTAAENKVLELEAELEKARSALEEASASKDEDAKQAEESQTAALAELQRQLDESIKQGEHHRQRAQQAQDDADAAKKSVASMEERLKQLTLDHDQKADQATKEADSKLSEHREANEALQMSATVAAEAASKREAELLSHTEKLQQELDAAKSELAEAQDKAREAGTAGEQDASALAVKDAELATLREQHETLQAKVEELVELQSRNQELQERVAKLEELQEQNQSLQAEIEKNASAFETRLAEAVASAEAATLEKAQKAHQEERGALESEQGESLKAAVEQARAEAEQKAAAVLEDAVSSARREMSDANAKSLERALKEAEAKHAEQKAIEIEAARREAEEKVRAELQQDHESSLEKAVAEHSSRHDEELSVLTAAHETALAKARDEHQSELATHSEEADERVKALQQNLDKIQAELASQEAVYAAKVAQVQAEHDQKVMDAFEKARAEAGDHHSTDLQTLREQSSKTIEQMRKSHADELDALRAAHAAAVSEADERGAGELKRVQMELDASQNDFKKLKETVSQLQAEKEAKDSRIRSLEAELASAADEAKRSASDSAAASSSEAALLRKQLEQLEQELSEVRNAHNQSQTAFVEQFEAISTQHEADKEALLQKHVDEVGALTRKHEESLVPLREKGLQDLGKLMDLQDQLNEAERERDAAKKELALLASKAAATEPTTAASLLDSQGKENQEMSDLERLHAAHTEKMALLSNQHHEQLEKLLADRRSERDELEAVRRDLQNAKMEVQFLTQSQEDADKLKHEVEQLEERLRQATSVGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIG0</accession>
    <name>W3VIG0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIG0"/>
    <dbReference type="HOGENOM" id="CLU_096652_3_1_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF53">
        <property type="entry name" value="TMEM14 PROTEIN HOMOLOG YJR085C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10474" checksum="48AB8866BB0E177F" modified="2014-03-19" version="1">MSEHPAFTMAGLCSVGGLIGFAKTRSIPSLVAGVGVGALYALAATRIKNGGDYGYEVAAGASALLLSSSAPRFRKGPVPMGLTLTSALALAYYGKKVYDFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIJ0</accession>
    <name>W3VIJ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIJ0"/>
    <dbReference type="HOGENOM" id="CLU_035328_0_0_1"/>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000007">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="520" mass="55226" checksum="E8317A2EC31E32CF" modified="2014-03-19" version="1">MRINDLPLTPLQTIQKAEAATELDDDKHLKDQLDLDSIAFAADLLVKMKTTASISGSMELASNTDGRMGMHMGPGGMQKRGPPYTRKDAELLRRQSDAMNAEQAEGFFIGGPRPAKLFPTPIHELRKGKYATTGGDRGFMTVFEYDVRGHTMMIDVDTSLVRFTSITQALGKNKVNFGRLVRTCPALDPHITKLKGGYLSIQGTWLPYDLAKELSRRIAWDIRDHLVPLFGYDFPASCLRPDSEGFGQLAIGMSPKRARKRHNNGGPHQTSCYGPSLPISVVDGETIEHKAPGHGGVGLQPHLPVFHYTKAPGYDRAWCADEAATRHVMNAGQDSVMWQQAAANAACGPNLLQLSSLAAASHSQCPPTMLELDTHAANAGNSSSPIVSSPPSSNASSSSGSASQGQGYANYALMVPPTVPSHAAGGDALADGGSASSLFLAQAPMSPPKTSSSANEVGTCTGMAELGYFDTKPPLWTATSQVAAYLPSRPTASTPPNGSGSSAPGVQAFQFEWQQSSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIK3</accession>
    <name>W3VIK3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIK3"/>
    <dbReference type="HOGENOM" id="CLU_032862_0_0_1"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000100">
        <property type="entry name" value="Related to acyl-coa thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="122"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="341"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="503" mass="55706" checksum="2BDA098C83A9AF4C" modified="2014-03-19" version="1">MLSKTSTSSGLTRALVRSLARPSIESAPCVRLHRNLTNQASPLQETNAVREIHKLMAEVRGAHPQKLKLSMPTRLAPRRSWMKEMQSQSQQSSSPESSSTPSAPSQYELPESMLKPKRMQDSYVELYLPFTEDPELLEKYIATSGLIRLGKVLEDLDSLAGGISYQHALGGRPGEVSAPIYIVTASVDRLDLLAPLTADANYRLSGHVIYVGSSSMEVFVSIEQLTPPTQPNKICLTGRFTMAARNAHTLRSQRIAPLILETDAEKALFAMGESHKNRKRAEAASSLEKVPPSKEEAFLLHSQYIRGLHAGMFANTDELHGPTLKADPVTSADGSTLVPVRRTSMSTTMHMHPQQRNVHQKIFGGFLMRSAYELAWMVSASLVNRHVQFLSLDALSFHAPVPIGAMLQLSSQIVYTSEPEQHPHGHTIAGVTVLAEVVDLETGERKKSNTFHFSFDLGTTNLQVLPQTYKEAMEFIEGKRRVDLGTEMRRLYQDDHPAPTADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIN3</accession>
    <name>W3VIN3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIN3"/>
    <dbReference type="HOGENOM" id="CLU_1235846_0_0_1"/>
    <dbReference type="OrthoDB" id="2540975at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="214" mass="24121" checksum="0964E117DAA7FADA" modified="2014-03-19" version="1">MGFSNEPLVLPPKKPIYRRGGFWFIVILLCVIAAVVPPLVVYRDRLSSNSSPYDERPFWNGTGPNGNPFGTCFTMQATAFQPNWKGQQTTTWCGAQFNKTAPIFALPLINMSRAVNVSEPVTHDVDRDVWESMTRNWCGAEAKIRGPAGEFDAIYGDANVWTTIDLNMNLFETLKGVPIGTYADPDEARWMDNIRVCFTGNRTNVFRGYPYSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIP4</accession>
    <name>W3VIP4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pex19-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIP4"/>
    <dbReference type="HOGENOM" id="CLU_043063_0_0_1"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="48196" checksum="064B1F1996A42061" modified="2014-03-19" version="1">MSDTNAQKAAATTAPPPASSNVDDVDDLDDLDDVLDEFNAPSGSTHAAAASASATAETPKAQPKPQVEDAAESKVSGGEAEDVVSQDLAKELAEGMQALMKELGGQANANGEGLMGGGEGAAAGDAGAAAEFNEEELMRQFEAMMAGFGGGGPATASTSAASASSASAPAAAGSASKPANFNDAIAATMAKLKESDASATSSSAAADNPFAGLSGAEGEEMAKLLAALGGSGDLSGLEGAMDNPELTKMLEGMMDELMSREILYEPLKELRDKYPAYLAGAESRDISADDRKRYEQQSAYITQIVAVFEDPQYDAKDAQMAGRVQELMNQMQDCGSPPKEIVGDMPAELESLPGFGGAGGNEECTIITDNSFEVGMDCHAAKPPAQRTTRDDVDGNGVDGNGDGDELGDSSSSSTLLAASQPKAESSAIHPYAHHHHLGQASRRTHHPSTSTTYTIAAPSPSHDAQLLPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIP8</accession>
    <name>W3VIP8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIP8"/>
    <dbReference type="HOGENOM" id="CLU_019618_2_1_1"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000475">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="613" mass="66119" checksum="18C1183F55057266" modified="2014-03-19" version="1">MSSVGAHPLPPTDSSLTGQRPSAHTQRYDRQLRLWASSGQSSLEKSSILVIGASALSAQILKNLVLPGIGSFVLLDDAIVDAADMGVNFFLQPGESEGKYAAEEMCRLLTEMNSSVASEAKLQNSMSMLQAHPSFFASFTLVISVNQTRSFDLALSELLWSLEPPSPQVPLLRVRSAGMLAHMQISLKELGIIETHPDSVVDLRITRPFPELVTLAEHFDLNTTDTMEHSHIPFPIILVKKLAEWQSLNNGALPSSKDRDAFVKLINASRLAGNADAENFDEAVAALGKHLWRPLASKGVGGGGVPDEIEAMMNDAAGTNLSASSSNFWILVRALRESVAASPTHSLPLSGSIPDMKATSAAYIKLQNTYRGKALQDLADFKRIVSQTCAAAGVEGSIGDDEIEAFVKHAGYLKLIRGRSEKQRYEAPNQEAAMMAFLDPVNPCTFQHHIAFAAVDQFCESHGRYPGVAYAAPLSTPVAVPNGDSLPDDRRAAKRQKSQTPTGETDASHLDVKMRDAAAVVDTKADEAELLSMAREIVATKYGIAEDGDEWEKIEDSLKELMRSGDASLPPTTALMGGVVAQEAIKLITKQYIPADNTVVYDGIQQAIGVFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIR3</accession>
    <name>W3VIR3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Serine/threonine-protein kinase rio1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_04455</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIR3"/>
    <dbReference type="HOGENOM" id="CLU_018693_4_0_1"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="20">
        <location>
            <begin position="228"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="115"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="477"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="609"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS61424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="711" mass="78295" checksum="32A26F39C7752E6F" modified="2014-03-19" version="1">MEAGQFDDAPDQGSLDHESQQRTEQEQQRNLQLVQDSDSALSQKQRRLEISDILRASSDAEDSEDDDDAIPEEEDDDYDEDDMNAYGAVEDADWELARGDFTKQFNRSRQLASAINNAASSSSSSSTQMKASTAATPLPAMNRRRRPPPAASSTASSSKTTSALGAAAAAGPSTGQTRTASQMESLSKFASRVRVDDMYDPSSAIGGGVNSTVPRKALGGRDVVRIKDKADRATVEGVLDPRTMVILYKMVNRGLLESVNGCVSTGKEANVYHATTASAHDAATKGSLALKIYKTSILVFKDRDRYVSGEFRFRHGYAKHNPRKMVRLWAEKEARNLKRMVAAGLRAPIPVELRDHVLVMQFLGDSDGWASPRLKDADEMISSDAATWQRLYRELLASMRIMYHECRLVHADLSEYNILYHEGHLWIIDVSQSVEHDHPRAFDFLRADITHVDEYFARRGVHTLGLRRTFDFVTSEPAAREGGGARKGGRAGLEKQEADFDEDKPNPNAAHDAQLKRHASAASESGAVVGNRVTGGGAWYTGLHGAPAPAPAQLAGESEAELMHALEELMHQLSLEPALPDPAHNTAADDEVFKATYIPFSLHEVDDPEHEIQVQKAPTQQKPKAPLENLLPTSSSQDSSEEDQDEDSDDDSEDDDSSAEAVHPKDAKLSKEDARAAKKEAKKQTKAATREKRKTKMPKAEKKRRMKKNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIT2</accession>
    <name>W3VIT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Laccase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIT2"/>
    <dbReference type="HOGENOM" id="CLU_006504_7_1_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13886">
        <property type="entry name" value="CuRO_2_MCO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="136"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="279"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="541"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="75392" checksum="279E5C7D9A2B8C93" modified="2014-03-19" version="1">MSAAPIQGSDNHGSTKSLSLAENGSETSNLKEAARASPSPTKRRLILLASLAALLSVLALALGLGLGLGLKHKHTPQQDAAASNAKMVPGATASDLAFIPREDLPDPSQLTLDPTWDRFAPPQDRISNWTLTQVLSNPAGTTKQMRLVNGRYPGPLVQANIGDRIIVHVQNDMPVPTSLHWHGQFQRGSNQMDGSAGITECGIAPGSTFTYNWTVQQSGSYWWHSHYGPTYADGLFGPLILHGDDEKFRMTNPSNTTNIPTNATTTNGSSIRTDYDRDLIFVVNDAYQADAFNVAAIAKSKAGPPGGDQGSEPTPDYAMINGLGFSNCPLAPNGTTCISDQPHGKSAYNFTVPANKRVRMRVINAGSMATFRFSVDGHNMTVIEADGTEVEPVVVQSLNLMVAQRYSVIIDTDRPIGAYAVRAEVLDDMFAYDNPFLVMDQYAIMRYEGVPASAQPLSNPTNATLVNVTESLSTSQLVPITRVDAPASNMTTKLVVNFGLDAYSNWHAFFNQTTFTSEMAPQASLMKAYTFETTQRASSNSSVGAYYNDPDELIVTNSQAVVMDVIVNNLDEGEHPFHLHGFTPFLVGSGAGNFQAQSNPNFAAAKTNPMRRDVFSVPAFSWIAFRFVADNPGVWPFHCHLMPHMAVGLLMQFQVLPDQIASLPISGQLYSQCSAVNSWVQQNQNLLTSTGNPDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJQ0</accession>
    <name>W3VJQ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_04980</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_2_7_1"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000032">
        <property type="entry name" value="Protein kinase rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="16">
        <location>
            <begin position="1592"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="15">
        <location>
            <begin position="2279"/>
            <end position="2594"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="17">
        <location>
            <begin position="2599"/>
            <end position="2631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2549"/>
            <end position="2575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2565"/>
            <end position="2575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS61042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2631" mass="292191" checksum="C282DACF2AD7F913" modified="2014-03-19" version="1">MPAQTRALDSGALGALLRKVVGSCDGIHSGHNGDQSSSAAAERVRGHHADHASALAAASQCLAQDLQEDRPSDAAINDARDGSHTEESIAHALNRLLISGVLTSLTHSSLPSRQDVDAHAGTAGIGIRQALDTLSRTLASSPKFLEHLFEPSCQSSTSAPSSSAVTLDMSNTTFDVWAAPRLLCAAASMVSASRSTPAVASSDYSQRCYDLSVNIMDSLELLLATSIDAVGQHDNVRLILAECLRVSVQALAQTGQTSFSPRAQLPDYFVPSVDLKRMLSTAGPSAKFFGSATPAPSFRLSSRKDRPKPSGKSLSALSSLRMDAAFSFPLLVDSDSQLDPHARASAITDRASALVISSIDLTLRLAEKFPYLVLDLADHAMLLLSELSLHRWTRAKQKHPCPALHTPWAAHAYDVLSRHVGFVAECSPASLMRVLQIGAEHISALSDVTEDPHLDDRQRFEVIQSLYALGSFFSACATETPKQRHTELALVLQPFLGLLTRQVRSDTDQATQPENDLRSSALRCFLAATILCVASGTCRYDVQLLQDLDAHIVELLRRRNTSPDTQELPRQQHDLRQLIALRDVLRTLSSPQPVSPSADDGQFRSRLRSLKRRKLGNPASSSKARAVIESLLPIEATLQEPGEGRELARRQLILRSCHGKEGASKKDNHEPGGCVCEDAVSEIGESEGGPEASAGSALIDPETVTALWDDVSAALKASKVKSARTVDIVRRYVAHAPESPQFPSDLDAVVHNVVARTVRSPSRGTRLAANELAMAWQCRLLRQRNEGNEAEWAAQFAWIPNIYEYLLGDSSASAYHETALIGLGRFFELPVESCQEKCLLALVLHLGHSNPFIKACAYTQIVQIAATQRCTTFQLVQKHFEKVSTSIVERFISMPDLWTSFLSLIKMNQATFFNLTKEYTLPHLISMICTGGRAAEVGTKMIELIARALGTDVPRLCHDNITPIFRSFFMRSAAIRDRGLNTLVQLIGVDAASLKILLRSRQSDVVGYLVVKLGNRATRKEAYAGLEFIIETINGTAAAGRATDPMQRKSKVAAFLKSEILAILTWINQELSGEHGRRTATELAFALRSIGALVEIIGPPITAVTPQIMATLNSHLQPDALSLATLESWKIFITTLRFDDIGPFVGQTAAALLSAWDRFNQERKRIAVSILHYLVIENAAYLKEYIDDIPSLDRLDAEIPEICRGLRSVREAWNHDRRFRNILVRSSHENTSICNESLKELQAFLSEERSYIEALTSGDSFSPLIGQCVRTLMHVAARSDTQHTSIRDLSFRCFGLIGAVDPDRIEHAVEEPLKIVLSNFEDQEEAIDFSLHLIRDLLVPAFRAATDTTQQNGLAYAIQELLKVAGFNSSILAAGGARTVGIKTRQRVAELSQDVIDTITPLLDSRYGAQVGKPSVRETPIYMHSKSYSDWLQSWTSRLIAKTVERHEASVAASTAVGGINTGALKGAEVASTIFGVFRVAIRSHDVGIARHLLPHLVLHSIISGDVADREAIVDEMQTILQDQVESRTSYDPERKLLTAQTLFTIMDHIGVWMRRKRQDLARTSRRPRIAQGGEDLLVGVESTMLRIPQELLAQASLQCKAYSRALLNFELRVRTMRVQGKGDHDLQSYYENMHRIYANLDEPDGMEGISTRVISPSLEHQIREHESTGRWTSAQSCWEVELQQRPNDPELHLGLLRCLRNLGHYDTMRTHIRGALSAHPEWEDLLDAFRVEGACILGDWDEVEARTQRSQAKSAQHSIGRALLAMRQSDADMFGNVLVQARQDLGKPLVAAGTASYPSVYDSVLHLHMLQELEMIRSHAGRHSGSRAVTRANFSDTVSDLNKSLTARLNATLPSFRTQEPLLSLRRTAFAALRSSLGGGNEVGEAWIATAKIARRAGHMQTAYSATLQATQNQATFAFVQRVKILAKEEQTHAAIRDLVNSLNTLVSSFKPTEHGDTGRSSVIELQGTDADGRTVRIDRDAYAKACLLRARLQDSTFRYTANEILDRYKEAAKEQHDSEKMWYHLGHFQDTHEGLLPNMAMQRYNVCRAFLRSAQVGTKFFYRTLPRVLTIWMDMAADDQILNFNKKGPTADAELAQKFDAFAQLNILMKRYSRKLKPFQWLAVFPQLVARIVQKNEDAWMVLQDMILQVLLAYPQQSMWSMVAGASSKDAERKRRYNEIIQRLGSKGGASHKEVVKVVASSQRLAKELLRLCDYSVSKNETVLSMDKLFPGLLEVAGTSELLLPLQSSMTVLLPSNHLISEMHRPFPSNLPTIRTFDDTIEVMNSLQKPRKLMIVASDGNRYPFLCKPKDDLRKDARLMEFDSMINKLLQSQPESRKRKLYVRTYAVLILNEEHGLIEWVPHTVGFRHILTKLYNGKGMQIYNSEVKTHMDEARISPDARTTEKIFQDKVLANFPPVFHEWFLATFPDPTAWLQARSAYARTAAVMSMVGFVLGLGDRHGENILFDSNSGDTVHVDLNCLFDKGQRFEIPERVPFRLTQNMVDAMGVTGCDGVFRKSAEITMSILRDNRDSLMSVLEAMVHDPLGEWSGPEERHRSKHSSSKRQDPRVVEARRALDPVAHKLDGRIYRLGSREPTPPYTTNNLVDALIKEATSPVNLAKMYIGWSSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJV4</accession>
    <name>W3VJV4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJV4"/>
    <dbReference type="HOGENOM" id="CLU_456438_0_0_1"/>
    <dbReference type="OrthoDB" id="6259853at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="65960" checksum="0172418C0D99CD44" modified="2014-03-19" version="1">MSSYAQLKEMALKKAEEEQASLNREREHKEREAAAKRAAREAQEREQKERERKILVQRMARQKEEETRERLRKEQASKLRNETIATDDPIAKSKLAGGAGATLSRPDADKLKKPGSTWRENLSGQLKANSNSNPVARRKRKVDEDDFVGNRFDKPSRKSSSSASASSSASKRKPVPLTREEKQAMRRAREFGSLPRLPPISRVGATPSTSRSNSSINTSDASANANRTSARAHLAKENGLVALGTKKRDHRSIDEIERDLRRQREEKEQSKKEGMSEAERERQAALLRRQRAMEGKRKSDQQDRERQAAKNEAENGDGSDSKEDLYGSEDDRPSGSRASQQKAAKTNGLPSIPKRPTNVGAPPTPAQPKEPKPLGGRAAGGIDPADFLPGAPLRPEVMARLTEKAKSASGRGHAARSPERDAAPQAKRVAAEAKTSPAAPSPPASAPPRRETARDRFIREQEEKKKKLAAGGSDRRDELRRSGSPDEYESEEEYDEDEYESDGMSDDEAGGGGASYRDEIWKIFGKDRKKYASRMVDSDDDMEADAGSVLQEELRSARQAREEDLREEQREKEREREKMLRKQAHKRASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJW1</accession>
    <name>W3VJW1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJW1"/>
    <dbReference type="HOGENOM" id="CLU_023751_2_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834586" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="50684" checksum="7D9B70F8AA5132DA" modified="2014-03-19" version="1">MRCPTLSSAAALLLAAATGIAADYVPFGHERPHHLARRDASTLTAKEKGTNLGHQEHSKPKAPSGSRLTSLSVGTDNHELAVYWTRSPANEKAKQAFVMIHGRNRNGGDYWTTMNDALASAVNASYPAADPNAIVVAPQFYSEKLNSGQYKKHELAWDDINAWQAGEAAIHPTGSKETSFDALDAFADEFTNTTKYPALEELVFVGHGGGGQLINRYGVVAKEMSTSRVQVRFIAGDPSSSAYFTEHRPTTNAAIADKASCPLYNTWRYGFDNFTGTLDGLKTPQEYFAQNVRRDVRYIVGYDDTAVSGDQYCMAILQGGVARRDRNLAWWKYINLLARTGEDVSGFPGNLTAEELPDWSSLSGGQLAHTLTVIEGATHNADEVFGSKQGRTVLFEKSQTNVQRGWRPKGWNKAGTPVVSSSASASGAAQAPTSQATTASTQASTSPASKIQLPASAVLAAAALFAFISLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJX2</accession>
    <name>W3VJX2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase dna-binding domain family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJX2"/>
    <dbReference type="HOGENOM" id="CLU_405497_0_0_1"/>
    <dbReference type="OrthoDB" id="2556737at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051491">
        <property type="entry name" value="Recombinase/Transposase-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36172">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36172:SF1">
        <property type="entry name" value="RESOLVASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas12f1-like TNB" evidence="3">
        <location>
            <begin position="670"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="723" mass="81280" checksum="EF8B06E054CAEDF5" modified="2014-03-19" version="1">MAPKDRSLPLIPPYRIPSLPLQANMTSVVLSNIARSKREMPRRGPDRGHHVYPFYDGHLAHKYHALVRPAQANQLSHESINTFEPTEMALSRCWTFAMVTDFAATAGQQKRWPFTHTTVLDCSSDYFPTDQGRLPVEDLGNEVVRAILQAADVGPAFPSAGSGAADPLAPVAGQVPSSAANAPALAPLARQAPSSVVTAEPTPMDLDHAPAPPGPTPSAAAAAPPPRPPPPSTQPTPQSSQTLVNKPEITNTRTAVYRIHAPTELKDRIRTFRRRTRLVKNEAVRLVNMATSTSHEHLNERRLYTLLANNGSAFSSKHPELLRCPTYARRQVILEAVAQRKSIITRYENLPGGRRRPLPSIRPPTKQTDKRRGFSVAFNHDTGRIEALYDVTGTEVTGLKLVMPAVTIGGTRYSEVRARICLRGERQRLRLLELCRWSRANAFKLPREWRVCCGADGRWYLHVLYELVDPKRFNADQQAEKKRRGITVLNGAIKVKSIDPGARTPFTVYTSEGETIDIGGQDDRARLCELRLAADRVQSRINEMKRLNRRPSTRVSREMRKRRFVRPARERSELHKRWRRIMADIKNLVKEVHCRTAHFLALSSDVIVMPRMEVLGMVRRRRSRLKISTKRELLTWSHSAFVNRLAIKCHDIAYDARFPHKAGHPTLLLVQPEAYTSKTCGACGRLNDRLGSQPDFLCPYQDCAYTTGRDHNGAFNMIIKAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK10</accession>
    <name>W3VK10_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK10"/>
    <dbReference type="HOGENOM" id="CLU_314762_0_0_1"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="692"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="818"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="929" mass="100411" checksum="F04108F92FCCB027" modified="2014-03-19" version="1">MPPDLAPHPRSTSMVRRYRQSPLVLARDLGCCDPAKPVEQQKYRKPYRVSGSSSRYQCGVKLVRLEPPTQRLLTPLPPLRPACIQPSPVSPRPSTLAGAMSLVPASELGLTGDLHLHHQPIAVHFALVKPSLALSGSGSELRLPCAWLRPTLPLFILRPLVSSQSLGSRVPRPLGEKHPPVAPAFGTHLPYRPSHAHSLRLKTSLSLHPLNPRILGLRLQTTHIVSAFFVPLFEQVLINTLIGHVPPRPLRPFIIAGHLFPFSSLLPQVCKSAKKPSFTQHTGSTLATYRFANVSVCLDPLRGPSLVPRSALQRLLNSLLYLKPSSNSTKSTLSLLCTDKIDSYSNDAKGSSSDIIHASTPGNHVAPLSAAPAADGPAGTGPGKMHLSKNFIEQADAELLAALGYKQEFKREFSSLEVFGIAFSIMGVAPSIASTLIYSLPSGGPISMVWGWFIGCFFIAITGLALGDLSSSMPTSGGLYYWTYTLSSQRYRRFLSWTVGYANTLSTTSAVASIDWSVAIMILAAASVMTDGRYVPTDGHTYAVYLGVLLMHAVLTSIGTRALARFQTVATVMCAGLAVAICIVLGTATPSEYRNSASYAFGGWYNETGWSNFGAFLLAFMTPAWTVASYDSCVHISEEASNAARAVPMGIFFSIVSSGILGFGIMVALAFNMGTDLEPIVNSEYGQPMATIILNSVGKTGFMVIWVFMIIVNFMMGASMNLASSRQIFAFSRDGALPFSGWVYRINSYTLTPVNSAWWSSAVSAVLCLLGLVNSVAVGAVFSLSVIGASIAYTIPIVARLIAPKDRFKPGVWYLGDFWSYVVGWISAVWLTFITVIVCLPSYIPVEAAADMNYACVVTVGTFVFSSAWYYFPKYGGVNWFQGPKSNIDDEEVAAHQVATQLQADEDAKKAKTQQEALNQTVQVDDYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKF9</accession>
    <name>W3VKF9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_03553</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 15">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP).</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKF9"/>
    <dbReference type="HOGENOM" id="CLU_159435_0_0_1"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12427">
        <property type="entry name" value="ATP SYNTHASE E CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12427:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT E, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 15" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS62000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="91" mass="10097" checksum="E912A46F4CD779DF" modified="2014-03-19" version="1">MTGSPVLNVVRYSALVGGIGYGILHRRTLQAKADVKAAHAEYKHKEQLIQKAKEAYKNRLVAKQSSSGVETDPESPAFDLEKFLLKVEQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKK2</accession>
    <name>W3VKK2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKK2"/>
    <dbReference type="HOGENOM" id="CLU_1396890_0_0_1"/>
    <dbReference type="OrthoDB" id="10438171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="195" mass="21050" checksum="EA30B51E04CBD0C5" modified="2014-03-19" version="1">MRTDAKPGQVLEYFGAARVRGSKIGGKPSPVMLVWMERITTAKTGAWRHESWASELADFVNARYTLRRSEPGGKPSQVGAAFEPLSTTQHLAYTDADVNRSLAPSRGREVEAGEYEQRQARRFQHRAWARPGLESALERSQPRCRADGDARALGTIACVGRLGTGPSDTGHGWAALSCDGGGCDHAGVRGERSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKL1</accession>
    <name>W3VKL1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKL1"/>
    <dbReference type="ESTHER" id="psea3-m9mhk2">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383155_0_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="194"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="700" mass="75662" checksum="2F0DEBE1A3EC7D2B" modified="2014-03-19" version="1">MTDSSAAHDVVLPLQGQIRPRRVHLPAFLPSTSPGSVLVYLGIPFAQPPVGARRWQAPQGPLPSWPSVRTSTFGADPHQDFAAMEGMYRGRTSAKTTIPRTEDCLYLNVWVPTTPCSTPRPVLVWIYGGAFAVGNCSRPLHDGARLAHESGCIVVSITYRVGAMGFLGSRALVAAAGDWPLLSVDALHTKPSATQVGAGNWGLWDIVAGLVWVQVSIGAFGGDAHNVTVFGESAGSIAIHYLLLSKAVPAGLFHKAVLQSGVVATLLPRTTHASQACWDFLVRALCPHLEGDDEAQVEYMRTRVRADQIDAALRPLIGKRPRSEYTPTRADVQRLPAAREDADEPLGVTDQWGPVWDGVLVDADFVARAMGPLPPRRELRNGRGGVVLGLCADEGTMFNFLVATSNALLEHQALFHPSLAADMAAMYGYNAGALAQPLRGRDKTERDRTAAYTCATYTGDAQFTAPILDYMVAQRQQRDDVAVYGYLLAHRPSLGMLDALTVVPEMTEDWAAFHTLDIPLVFGLTGSSSGEAHAWAGDIAQYGTDAVDEAKTASVLSEQGGMSSGERQLSMTMMRTWAAIARLEGELVLPDASVWAPLGSSRTNGDPGNIGNIELLAFGEAPQAPVPLLRESNEVRVWQTQLGEHPFAQHAPVGAALLHQRVQFWLHQPISGTSKQTCRAMQNYYGWINEPPRFLPWPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKQ6</accession>
    <name>W3VKQ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006747_0_0_1"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="162"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1267"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1376" mass="148186" checksum="5FC2A3A75F75DF2C" modified="2014-03-19" version="1">MPRQPSSPTRSRFISSASPTKVDSAIPEQSTSTYALDPSLVPYTASHFSGSSVSDSITRAYYVDVVLGQASSSSHSGVPLSFSSANLAKPSDAAAFTAWLGELVHDHDADPLAGSSLPDEHSSVPKSASGSSINAVSSSSPAPPAASTAPSSAKSSKVDSARLFARVQELIDTERSYVNRIDVLHQKYAIPLRTLAKDRDTAIIPLYEAQRLFGNIGEIAGANRAFLNDLERLASQGQDSLRAGLGDVLYNHMSCFSCYTEYFANFEKAKHIEQTLAKHRAFCDFADRTKYSVTGIGNTGIRDLLMEPIQRIPRYKLLIDAILTHVDARDPLRSRLHQAITLVSRIASCEADEKTQRAAILWSFSRNVESFPAELISAHRRFIDCIDVDDFPLDPSAASSGIIAPFSGLKPIHCSLFLFDDRIAVVKRSSASTCGRKRIGLDDIGKLASQMKTFTERSSHAPLLAQSKRPELAFRGSISLADIDAQDLGGSDFQLAFLRTPSHVTGDKWVNRPLRQYVAVDASSATPLTLASRAQMGSSTLDADVAAKLEKMRFLDNVWRAKALYKARQSRCETRCRIVPASRRTMSDDAMVGPPRPVADPSDVRKVIYFHLHSTATFEHEHSRSPLALSLDAPTALGTSESALPHAILDIIEVDEMEEDFVGQVRTKGADLTQVSGEPYRLASADLGDHAVQLSDEVEKRYGSLVQALAQSQPGTPSGSGFRHRAKAAAGLENFGRSLLFGSSGANSSISSAGISNLDVFGSPTRRSNSNASKSTFSSNAASVSSRGMTHSTAGTSISSRSGAFEALSRGNADSPRSFRRFGRRRSSSAGPPSSVASRCDADSAEEDDAHLQRRARAATPDPVSLLAGSSLASPRKLGGANAAGGRTMGAHARARTESAAATPNWSPSKAQPPYQQRQRAESVELSRTPSSASRKPTGPREQTSPSPAPRPHSRIEPPSPSWLFSGPTTPLNIRRKPPPRMGSATDDENDAELATPVRARPASSIGVYAADRASSNAAGDTSVTKRRVSGTKRPLSSSGYDSLAAHADESLTKRPSLGRDYDDLDAKQGPALLPRSAPLARLSAEEPSAQRPSISESETSTERGHGADGAKPIAEASASGKAPVTPARTSSTASKSQEARRRNEAVEHGLRLVKEEMNLLRCDVEILQSSLSATDGDARTPRKRRGDDAVLAELDVNAAASISAEVDHIHARLKKLAFLLSNVDAKWISAIRMHNRIMHDLTTATSALAAAQASEATRNATSSGPDEAVLKEKQQLEIQLAALKRKCELLTTLEADGRLENTEIHKAFNEELDMLYSHTQAPENDELATLRNELKRTKHDQHELMLSNKRLKRDLAIQQSQAETYRLALLKHGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKU9</accession>
    <name>W3VKU9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKU9"/>
    <dbReference type="HOGENOM" id="CLU_1482612_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="182" mass="20012" checksum="16DC926B1735A510" modified="2014-03-19" version="1">MHLGCFGLNLNTASSVKQAKRERQPKRKRKEHTRAAQQPNTAIQLSPGTLFQHSTAQHSAVQCSSTRAAQRLGRLDFAMAAQSSRAQLSPVQPSPAKLELISLSAPHLLCLFDPTPTLATIFDLRSSPSSFIPRLLNTRTLVFYSCQSPLRSFPALPLRLLSIASSSSSRACIRPSRNPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL59</accession>
    <name>W3VL59_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL59"/>
    <dbReference type="HOGENOM" id="CLU_425210_0_0_1"/>
    <dbReference type="OrthoDB" id="2278929at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="594" mass="61970" checksum="9343161E2495E215" modified="2014-03-19" version="1">MHLVGESSRSALRRSADELLKHDSDHLQKRSPSPAPAPAPAPAPAPQPTAPPTRRTFEEPEHLLVRARDFSERVQQHQRGAADEETILGPFWARDMDDVVRIKRDVLAQPLDRRLDRLPRAQPVQRAIQRRQTAAQETCYVGNEDLSCYPTAGTTVAQNTWSKFIWNANYPLFAQRGFVDVYLFQQDTDRLVTSWTSQDNGAGRVSFQPNDSWWANRSAANNIQPNQNISWPFYFVVLASGQPLSGTTSRLATFTAVQTTLPFSIAQARASSSSAASAASASSASEASAASAASAASASASAATATPTGSAAAAASSLQSSLSAALESSLRASGLSGTETLQGTTTATLPNGSAVTATATAQANGGRLGGSSGSGNSNGLALPTYAIVLISVLGFLAVVAAMAGAYFIMAALRRRRQRQGGDGSHRSSSPMMAAAAGSLAGRSLGDAGETSHMLETEERGRRSLGDAGETSHMLETEERGSAFPSAAAAGAAGVGAGAGGAAMMSSHSRSSRYSEEQPFTSDEASRMADAFRNALRNPEFAPVMGGESSGADGESPNEAGGGSRASALLREELAAEGKDLLSVGDRKKPTWHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLC2</accession>
    <name>W3VLC2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04087</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLC2"/>
    <dbReference type="HOGENOM" id="CLU_145518_2_2_1"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="71" mass="8295" checksum="5DE7A92B8F854DE0" modified="2014-03-19" version="1">MPQLYRDPWAKREAWRKHPVFSHRFFARNIFPGFGLGLGAFAVYLAVDTLTHPSNIEKLKEDARKQTGRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLQ3</accession>
    <name>W3VLQ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLQ3"/>
    <dbReference type="HOGENOM" id="CLU_022453_6_1_1"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="141"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="384" mass="41527" checksum="074288726458EC17" modified="2014-03-19" version="1">MKRQYPAATAKPASAKGAGSNWKALKKTLQPEASSSTSTTSQLGRRKSHSFQPRPKRPKLHDDVSPNESGGSKSSSPAPTSLPWFAEDISPQDLELVRQSASDKMSRSGQWEGIMDAELKKKVILGGLPSDANPAKKEPGNYLAIDCEMVGVGDKGSESVLARVSIVNFHGATIMDRFVRPQEKVTDYRTWVSGVRPRDLKGAPSFSEVQGEVAALIKGKVLVGHAIQNDLKALLLSHPKPLTRDTATFQPLRDLAKTKYPSLKKLAKLVLGIDIQLEGESHSSVEDARATMAVFRSQKSKWDEELRAKGHGGFGGSSAGARLGSRSARTNKVWKAPANGQAVDPASPALDKRPFSSSADNSLTDTVRLKPRMAAQADWWKESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLR8</accession>
    <name>W3VLR8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLR8"/>
    <dbReference type="HOGENOM" id="CLU_024521_2_0_1"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="581" mass="63000" checksum="4FCCC53748F4130F" modified="2014-03-19" version="1">MASFKLPQLQPDNDLWGPASGSNALPSQLKDIPFAPYAKNDKVGRIADWNNASGASNDAANARGGRQGRARDVQQNFGTSAASSAFAYFHGDDEASFSVVDNTRTAASRRGGLGQMSQRGGRGGRGGAGAAGGRGASKFGAAAGRGGGARGGRGGARGGRGGGRFGWKEWDKPQRIREASVAVGQDWEQVEEIDFVRLGKLRLDVDEPEEISSYGTLYEYDRSYDRVTVKTSHALSSLDRVRYNPTTSDDPIIHDIAAKHDAKIYMTDSILALLMCATRSVYSWDIIITKTADGKVFFDKRDGGPFDFLTVNENAADPPSEAPEGKENEAAAKANALNTPSALSLEATYINQNFAFQIVNEKNAYRLEHDNPFYSADETDPAASCAYRYRKFNLSSEEADPVELVVRTEVDAYTLGANKDKQLITIKSLNEFDSRAQGAGGAPEWRSKLDTQRGAVVATEMKNNSFKLARFAVQSLLAGADSMKMGYISRANPKDASRHTILGTSWLKPRELAGQMAVNLGNGWGIVRTIADLARKADEGKYVLLKDPNKQTIRMYRVPASFGEDNDDIPEEDETEAQNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLU7</accession>
    <name>W3VLU7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLU7"/>
    <dbReference type="HOGENOM" id="CLU_754646_0_0_1"/>
    <dbReference type="OrthoDB" id="2550114at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="367" mass="38902" checksum="049DE8426F57AA82" modified="2014-03-19" version="1">MPAHHASPTSVTALVYRGLLHTRAAAAAAAARLGLRARPRHAPLAERSEPPQRHLDGQPSSSFRFCSPSPLGLRMGAFLIQLRSTVGRMAPSQPFFRARQGSSPHLNPRVRRQFTSSSKESRRHLGADVPSDSSILSSNKHIFTMEKSKRDDVDALSSPSNPAHYFAYAASAFLITLSLPLLLFPRMLLLLSTPRGAVGQAASDADRSAVSAIGPELTPLERYASHTNALGMLAIAALILVLSGAIPVSTSPVPDASSSGKSPFRIPTVVISTVYFGLNAYSAWTFSGPNKPTGSIDPAALGIGTLGKVLGAAHAGFAFWGLAVFMFGNDLTRNSKKAGDASAKDKSVSNFPFKNQYAAEEKAKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM37</accession>
    <name>W3VM37_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM37"/>
    <dbReference type="HOGENOM" id="CLU_556824_0_0_1"/>
    <dbReference type="OrthoDB" id="2536450at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="490" mass="49568" checksum="446EBB7E29D66D4F" modified="2014-03-19" version="1">MPSLSSSASCERFAGSARKISRATVSMRVVGRSVASSHIDKDCSPSSGNVESDPLVAKKSSFYDALVSSGRPASSLSASLDSKCVFFDFGISAAAGPRRDARCPAHFATAQRNHNAKPTGDSEPERISAVLVRRASRAHWSGAAKDCVWPAQANLARQPPLSASTSSDSVPCAWAPTVEPGHHAASSRLRGDSTPLSAPPPSHSHEMRSIGATSLVAAVAAVAGLAGSAQAQLDPSLVTGLSSGCASSLVGIVTSSNISSCLSLPSAVGALTSAGNNSVVPGLNQYLSGSICGSGKTACTKDQLSAANSTLLQACGSDIQGSNGGIPALVAYFINSYDRLRTAGCLQDSQGEYCLVKEMYTLQNVTQMPISFSGIQSLLSNQSTQQQSLMALSANKTAFCSDCTHALYSTLFPTNSNAQLAGAVNQTCNSTFLDGKVPSTIKSTANGNSTSASSSSGSGSGKNAAAGINLGSVAAFGSALAAVAAGLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM74</accession>
    <name>W3VM74_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipid particle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM74"/>
    <dbReference type="HOGENOM" id="CLU_027968_0_0_1"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="493" mass="53984" checksum="373BE09ABCCE3D47" modified="2014-03-19" version="1">MPGGNVHLVVVHHGLWGSPENTAYLCTTLARFHGGVATPSSKLTPPESEATLSAHADTHANAGADTRLVVHNSSVNAADHTYDGIDWCAERLVAEVYAQITALEDDEARVTKLSLVGYSLGGLVVRYAAGLMYLDGVFGDKTATVEFKSRPEAASLSTIATPHLGILETGTTFSKVAAFFGGRILGRTGTQLYLKDRSWIPSKGSQGMCLLEALVDDRFAFISALKLFKRIDIYANAVADLTVPYRTAAFEQHDPFVLPLTLVRDPDFPVLLTSYTSKTPEPKSTWSKVSSKLSPRNLPWILNPQRIPFRFPLNYAAWLGLPILLPVMIGLVLHKLKSDSKVSNKRVAQFEQKYAQDHHHPPAAAADEMQQKRFARLLATVEADAEESLRELGEDFVDIQPKTPSHDKTDSNPTSISTATNHTAKSELPLSDIQNRIASTLNNKSLLPQVQKHLAHLDDVLNAHAVIIVRTTTIDAHKKGIPLINAFVQRFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMH1</accession>
    <name>W3VMH1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dik6, novel virulence factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMH1"/>
    <dbReference type="HOGENOM" id="CLU_026517_0_0_1"/>
    <dbReference type="OrthoDB" id="2546077at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="71869" checksum="63B6A938D6455155" modified="2014-03-19" version="1">MSRSGRSEIAVRGDQDSSLELSKGPMASTLVLSPLRSVLRELHIFSSLSEPNAWVLVGDGVDQASASFSRRCPVALNARDAEEWPELSIVFTSRIWEEQACTGQRSHRGRTLVASIMNASQHLDMPDTAASLHRRTDPQSMAFLHRGLTQDQVLVALAHTIYQPTPSRMRVYLCANQFEVVLTLVVCGAMIILKRSYSDVWLIARRRSAYGTFYVANALVTLIIAVSLYLIGWGIACVFNVTYSFAKLSALEWWWSMPLPWYPLLAGTYISVHGFVLGCSPKSPLSINSSANSPDGRQKWYFLCLPKSPLVINLALVIPLVAVTITTLTLVGLSGVSYYHAKHLSRQILPALFHGHLQEAAFEPHRFGKDSTLASDELIWHARVVAAAYIESHRYVCINLAFFAACAVLLWIPCIAYGIPNLLNLVDHACSRCPDPLPSTCNSYLRKLWFLVTKGKPTSEKSTVHHNLATWKMTFLAHIYVFFLVVCAPAYAWIPMYIVGTAYPHVALTGDIVLTWQVAIYAASVVTTISCTSAAIFSTLATLDPVFRAAIGFNVIRNKQPPIDITVVQRKSVHEDISLPLRTVADDHPQASSFKELLGSRGSRTVGLKPSASTLRSLNVSSDPPAYPYGTDLATSQPQIHVDYYPGSHSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMI1</accession>
    <name>W3VMI1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMI1"/>
    <dbReference type="HOGENOM" id="CLU_1225566_0_0_1"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF22">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833354" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25138" checksum="F1DB41612181A13C" modified="2014-03-19" version="1">MVRPTLLRAVLATFALVAVGAAASSDAPTSSATPAVPAVPDLDDDGQPLQFINSVVGDDDDDDYTPAQLAARSELRRSKHHHKHSSRKSTASRKLFTIGPAQTDEMWSRNVQITWYASNDLKNPQCGNGGGSWQPENSCHIGAVVKGWNDGPQCGEFVKLCNKEADNHCVTVRVIDKCAGCGEDHVDLTKSAFKKLSPSGSLVEGRIKGLKMYRTKTPNPWDLALFGPKLLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMI4</accession>
    <name>W3VMI4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMI4"/>
    <dbReference type="HOGENOM" id="CLU_007738_0_0_1"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000068">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="270"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="673"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114030" checksum="6CB200A2EE4F45A8" modified="2014-03-19" version="1">MSSARPSIGSSRPPVVPATPVGRSMRKKNHLNLSAKAFDKMSKRLLSVEKSTGQSAMSSWRTSDPNEPLAAASDRIEGIPELGEGGHRTTASYVIAEADENAANAPEVKSTTEYHLRRFGKAPVSRGLTQGAGKGPDGAALAAAAAKSLKGKGVAPVDSFLNEGSFVFNPLNRRVPQPTPRKAKMRHISSSSNAVSSRAPSSQPPLFSATSAQESAKPAMRQESRPDQAAPVPVAGTSSAAAATPASENEDPSFVPLTLVDRDLQEALILEDLLYVLLGIEGQYITYASSYDPEDVSHRLRGAQFIIDPSLDAPLRDLVDRILPLATDYTAIYAFIETDSGLEYGTVNHALCSATRDLLHDYELLVVQLEHQMASSASFSLQRLFVWIQETARTLAAVRALTDEIVGISHADLFDEEDDDDSSDGDGASDISGTSALERERRALLGLDDPEDEGVEGGIAKGGEVLSMLWDRITRMGGDPKAHALFTTLFQRASQPYAETLVKWITTGDLSDTYEEFMVMEDAKVTRAALESDPTDEYWETRYTLRDETTIAKRERQRQLGLDLDAEIEDEEENPRGFLTGGAKIPSFLEPWKHKILLAGKYLNVIRECGLEVPSDPDVALTDAASSEQRVGRAARSIAVVMNDESFFRRIEAAYQRANSALLKLLLEDQHILERLRSLKHFFFFSESDFLSSFLEQSAHELAKKVSPTKTRETVQQRLQTHLGAVLGSSSTVGFEDPYREDVRIVLASEGAYDQLKRIAETKGGIEATKLAQANAAAAAAAAAAAGSSGKETFVPSVSLLQFDVAVKFPVSLVISRKNILRYQFVSRGLFHLKTLERSLSELWLDHSSSALWKQRTHPALEKWKQRLFQLRSRMTFFVEQLLAFQMMEVVEPNYQDLERKLRNVKTVDQLMKDHFAFLNTTRKELMFTDLRYLELHSQLTTVINVFVENRTRFQDQLLLETERWKKAGGKKGVAPDPPLQESTHEFLARVQKHWERYAKTYKDVVNLLSTTDNPAALPLAYRFQSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VML3</accession>
    <name>W3VML3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VML3"/>
    <dbReference type="HOGENOM" id="CLU_110897_1_1_1"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000277">
        <property type="entry name" value="Probable nadh-ubiquinone oxidoreductase 10.5 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="97" mass="10547" checksum="DA089FC208B6BFFF" modified="2014-03-19" version="1">MSANALTRAFPKALKEVRLHLCQTGQASAGARKFLESNYKPIKQSNPDVPFLVREASGTPARAFARFERGVEKRVELDGLSSADVEKKIGELLSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMN2</accession>
    <name>W3VMN2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMN2"/>
    <dbReference type="HOGENOM" id="CLU_1138424_0_0_1"/>
    <dbReference type="OrthoDB" id="2550448at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834698" evidence="2">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="244" mass="25553" checksum="DCA01D0D1BA0BBBB" modified="2014-03-19" version="1">MMTTGSLSFALAGLTLVSGVSSAAIRNDDGYTTGIKVQPIIIETSESYGVTWKQTKLPTTNQQQGALGGSVKGHFPAMSPNETSVGCGLDWSLGQLHAGFDAGDGGNGVGGGFTWLPNALSSVIGVHFGDTKVNVNLTITDDNQVIFSVDGKELDWNKVIKATKTQDANILSGRDAGAVQYYHGHAFANDVPEYHYPDGKEKSTKTKRADLPSGPDAGPVQFSGGDAFAVDVPQYFNADGSIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMW6</accession>
    <name>W3VMW6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMW6"/>
    <dbReference type="HOGENOM" id="CLU_074873_1_0_1"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="192"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="262" mass="28780" checksum="CB24E3647F1770A7" modified="2014-03-19" version="1">MARLTEIEDGSDNEDVRASPNASSSSSKTAGLTQAQQEEILFKSGIIEKLGLPKDFVSMDEAQAQLDALKHGEAGPRVGEARGGAEQDGEDDSEDDYGVASDHELDGDDNADRLMQEQEATEMSPQVESILDLIIWTMPFGFMYTLLDVLVRQQYGDTVGLADEAVRLIRALPVLGFFIHFNLTSQRQALIQVLLFGICSACGCSLIYIVNKSPYDVVIQRVAPLGTLWIFSVVRLDLLPACISLGIVAMFVQQMKLRIMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNF5</accession>
    <name>W3VNF5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNF5"/>
    <dbReference type="HOGENOM" id="CLU_2777008_0_0_1"/>
    <dbReference type="OrthoDB" id="10445578at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="69" mass="7470" checksum="D386B13C9B475954" modified="2014-03-19" version="1">MAPQILTSIYPPLPKASYSNIFDYVSSESESSLADKVQFVRQDGKQFTVSDCESRGSMTGTMGTGVRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNI3</accession>
    <name>W3VNI3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNI3"/>
    <dbReference type="HOGENOM" id="CLU_466239_0_0_1"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019303">
        <property type="entry name" value="vWA_TerF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10138">
        <property type="entry name" value="vWA-TerF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="610" mass="64372" checksum="558A9EA04C6C3879" modified="2014-03-19" version="1">MGFNKKLIVAGLAVGITALMLYKASKKHQQPHHLAPAPAQHSAMSSSNHSHTASLGGAALGGAAVAAAGAAYAHHNAAAAPPPSANNPNLTWDSLRDWRHIANLLATCVMDQYLYPFYTFADVSRIAHHLASSGALAQCADSWQLPPYLAQDLVKLALFDVMFLLDDSASMRSEGTRRRDALAGILKRAADAAARFDPDGMEVAWMNAPVHQRIHNVQEADQLTSRCAYDGRSTPMGSSLESKILEPLVLQPAQQGRLAKPALVLVITDGRPTGSGEANQKIVRVLQHAKRTLAATRYGEDAISFQIAAVGNDREAQEWLDSIDNDPDVGDLVDVCSDIQVESRQVKASTGVELTQELYCLKLLLGPIDTSYDASDENEKISSWNRSAKRRREKKAQAKAHKEAAFRAQMDAFRRDRDAALQGATPVPSAGGALPPQVVDDGLSGYSHQPGYPQQHQQGAYSPPAAGYPQQGGGYPQPQQAGGYPQPGGGYAQPQQSGYPQPGSAYPQPGSGYPQAGGGYPQPGGGGYAAPGYQPYGSGPSSAPPPYPDAYGSRDLPAAGNSSYAPPPGSGGFVPGAGGFAMPNPHVGGAPPSDSQHQQQPFGFPQPKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNI7</accession>
    <name>W3VNI7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNI7"/>
    <dbReference type="HOGENOM" id="CLU_1409352_0_0_1"/>
    <dbReference type="OrthoDB" id="2553575at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="193" mass="21959" checksum="2387A49AD4125872" modified="2014-03-19" version="1">MSGRRWFAPSAIPPILLLTFVTSFAFNHALITTERRHQLRTHRIRIALLQDTIAFNTLRLYQLQPPSQSLLARLFKRPHEGVHVDADELDSLVRRWRAVGVNPFDQGLLPASYRPDSHSTDELRGGPKEVAWSEILLGSPEKRTSLTQRWQQVTAGIRASFSHPGSTQHPPDTPDDDKELEELGRLWSSLSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNL7</accession>
    <name>W3VNL7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNL7"/>
    <dbReference type="HOGENOM" id="CLU_040186_0_0_1"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="310" mass="32443" checksum="136E59ECCAB124BD" modified="2014-03-19" version="1">MEAVAAADTALNNATSLGLGMVMGGSESGVLPGTLSSYTTALGLNEALQHDPRALWSSFAMIIVSEIGDKTFLIAAILAMRQSRLVVFSGAFASLAVMSVLSALLGVMFPSLLPKSLTNLMAAALFLVFGLKMVRDGLQMSGDELQEEWHEAEREIEEENTHELDSLEQGHTTPSHSATKRAGGMGNTLREGTKNLCGLCFSPVFAQAFILTFLGEWGDRSQIATIALAAAHNVTLVCIGTIAGHACCTSMAVVGGSWLATKISVKHVTLGGATLFLVFAVVYAFEAYSEPGGVLAAENVVQMAKQAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNR6</accession>
    <name>W3VNR6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNR6"/>
    <dbReference type="HOGENOM" id="CLU_021265_0_0_1"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="6">
        <location>
            <begin position="294"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="763" mass="80398" checksum="6303B3EB6EC891DF" modified="2014-03-19" version="1">MVSAHRYGGAARELLSSAAYSRSPVAGPSRPRHSTAPPPTTTTALSRRQSLAQIRDPAYVARYRTLGPSAHPLLSSSSTLTSSASTEASASSAGHAGLSTTHASRSSAAVLDTAGPAAHPASSSVRSKSTNASDQLDDTWAFGGGAKSQGGPVGSEAPTPASHAKAASAPIVMGNAGKGAIPNYGKRKMNTIHLSAPSTFGGGGGGSSSTASSSTSKVTTDEALANRYEHRYSPSTRSEHPLPQHTYFSSPSSSFNASSFVAPGTQPPLAGTATGGVGQGHPGIGIVRKKTALIFPGQGSQYVAMSKDLYKAFRSARSVWHQAEEALMATPGIHSHHFIQGERAHSAEQRDLFEAELAKTRSLDPKQGLSASGTAVARSRRGWLRDLVFSGDQLELTRAENAQPAILTCTLAFLNVLRKEFSIDLVRDHVQWASGHGSGVYAALVGSGAMDMHDAVRLLRHRGLVASHYTAKHPVLFPPGCTPPESIYETWAFANAGSGKGADLLYDEDAADATASGKQPPGWKRTQMSGVVVRPGKLGAVLREVEQVSRDIREGKVASVARDEVVEVANINSQLQIVLSGTRVGVSYCCDRLRSKNLGARAVNLPVSGAYHTSLMLEASDFLRPAVKHMPLSDPEGFALVSSRTGRVMRDSATIREDLAGAFAMPVDWLSSIDTLIAQGVERFVCLGPGRACAHLLSKELAYRDKQRQAHQPDAQSAYEVWSLATLDDVQQLAEVLADVSKRQAILPAQPAMDADRLTADGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNT4</accession>
    <name>W3VNT4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNT4"/>
    <dbReference type="HOGENOM" id="CLU_013985_1_2_1"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000047">
        <property type="entry name" value="Acetyltransferase, GNAT family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="258" mass="29428" checksum="66B22CD8E27CF0AC" modified="2014-03-19" version="1">MITLSDEEALVRLGPTVPTDPAPYPSRVVIPGQYVDLVPVTPEHADALFPVVGQAEHERLWDYMLEFPFNGDRERFTQYVKARCGNENNMVFWAIQDKNPTPGAPKILGLISYLRIDPANRTIEIGNVMFSPFLQRSRKSSEVVYLMISHAFDTLGYRRVEWKCNDLNVPSKRAAIRYGFAYEGLFRKMFVLKGRNRDTAWFAIIDDDWPQRKAALQTWLSPDNFDSETGAQKLSLKEAHAKHGYTVPDSLALPPRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNU4</accession>
    <name>W3VNU4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNU4"/>
    <dbReference type="HOGENOM" id="CLU_322929_0_0_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="738"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="911" mass="98456" checksum="057279AB6A1D3A3C" modified="2014-03-19" version="1">MTTSARRQLFRRSKAGCWKCRSKKKKCDELRPHCTRCIRAGENCRYPDASSESLSEASSAMATSDYTSPSMPSSASFPNSLSSHAAHAAPMLSRSSSTSGYSSHASRHASHRPYHHHPYAPPQAHHLHSPPQHRDFQMQRPQAHQRLSPPARAASHISYHPAQHGGAPAHLPQQQFPPPPLSASAAAEWDHTSQQHVYKRTRYDELSSSSSSTSSNQPHQDARAGRQPFEPHHRVPSNHSQGSSKGKSRDTLPPISPHQPYSIPMAASASLPPFNAVSPQQPRTAASPILSTRSADTSPNSQASPYFANGPKEEDGNASFARREAATKHAEHSAGQLNASASGIHSEAVRSPTTSASTAATASCQKLVLDYSSTEPDPEELLAELTSYTVSTVTQQTKGSTAYFSFLHGIARMAQGQAMAHALAAMVATQQAKRSCKPQERQNDAVEDGAEETRALDLDASQQEKAALLLDLADRHHLAAIKALQTQTRPSRRRRFSVIESNSSTSADDLPAGSNAAAMMLLILACSFAGKSLMLPSYFNQCEQFLADAVEHVSSHRLFPSVTGEMVSGNAEDPPIEAPESVSAYGTLLFLGTVVGLYECYLAMYTAVTDWDYNPARLRRLLPFNWTEADAAIFDQARGVTSETVYSVSMVTWELIIETLDTMRKLRRAETVAYGGKKSSRSEADDGGAALDSLALREELGLLIRDLEAGAFWKGSHRILSEAEQLQVLDSLRAADAGAGAGGKQSESSDASAQMPPPSVPAEDAGSVSATQAFRSGALFLASTASGSKQVNRLRLANHLYRNALLVDLYVTVFNRAPSSLAVRELVSRSAALFNAIPDKLEQGLMWPAMVLGSYAEGAAERNQIRAFFARAQWKGIAGPATTADVVERVWAQDAPNWRESVSYFGSPYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP04</accession>
    <name>W3VP04_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_01680</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP04"/>
    <dbReference type="HOGENOM" id="CLU_013299_5_0_1"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="17">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS63398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="366" mass="39925" checksum="302DDEA91476A8A3" modified="2014-03-19" version="1">MVVRSGLPLESLLYCSAPMVGQSDLPFRLQTVRNGATSTWTQMYMAAEIIEHQDTLESLVKALELGRASTDNLIQDRKSSLHGSLALQIVQLAGNDVDELVDAARKVAPFADAIDLNLGCPQRHAEQGKYGAYLLPKQNWPLLSQIVSALVQAVDVPITTKIRLTVPKEQTPELAVTLARAGSSLVTLHPRFASSVRRRKGLADLDQVIQVRQALQNEGLLRCTHQPDGQTAVVSNGNVRCWSDIATNLALTGASGVMVGETLLENPTLFRPSLGDLDAYPSAAEMAGEYMNLRAEYSEFEAPLKVAKQHLHSILCSIPYTPNPHPDTTTHLHRKAAHISHTLKLIQSEPALTAFYNTHLTVRAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPE0</accession>
    <name>W3VPE0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03281</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPI-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPE0"/>
    <dbReference type="HOGENOM" id="CLU_019988_3_0_1"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000045">
        <property type="entry name" value="Probable coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="300"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="174"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="551" mass="59201" checksum="72AC269F012C8148" modified="2014-03-19" version="1">MVILAASVSTRGGKPVISRQFRDMPRSRIEGLLASFPKLISAGSQHTSVETDAVRFVYQPLEDLYMILITNKNSNILQDIDTLHLFARVTSDICRSLDESSVLRYSFELLGAFDEIVSLGYRENVNLTQVRSILEMESHEEKIQEIIERNKEMEAKEELKRRAKQLEMQRRDAARRGQMGGNSGGFANSGGFGSVQQRFEPPPTQAPVQTGFSSTSTPAAKPFKGKGMQLGKKSKGADLLGAMGGDLAAAAAAADEELTAAANAASASIAASAAANPSASRAPPAPAAVDPLDLLDPVHQEAIHAIIKERVSISGNRDGGLDSLEIKGDLFLKITDPTLAKIRLQLAPPEDGNLVLSAGDLQFKTNPQVDKAAWASDRVLAPRDARKPFPVNQSLALLRWRMVTKDETALPLSINCWPSPNGEGGCDVSIEYELENDQLGELRSVIIAIPLPEGSVPSVECPEGSWAVNEDTNNLEWSLDSISSSNKSGSLEFSVTSGAENVDVFFPVVVDFVCEKTLSSVSVADVVLADTSAATTFSQQSVLSAETYVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPG4</accession>
    <name>W3VPG4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPG4"/>
    <dbReference type="HOGENOM" id="CLU_009942_1_1_1"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="3">
        <location>
            <begin position="255"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 12" evidence="4">
        <location>
            <begin position="899"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1149" mass="126003" checksum="BD2F52C05BBC5228" modified="2014-03-19" version="1">MDQRQVQCALTNNYLRDSPAISPELAKPHRTPQETNTPDDIPPHHLPHHLLEPAQACIDATSIVAMAKGPDSAPDSGKMQTQRPSVLQPNFAPAKSGGRLLRFLAVVAAAVLLSSFWGLSWSKLHALHGKSALESLSERYVICSPAQHGRLHLGDAPTGSIYTGDEQQFAEQQGFAQCIGVDSGVITHVGSENDVLEDFCAEGVSPTSSRPGKPQQRRRPHSNKAARLARRSGTQKQDGALKKHGKCEVRRLRHGQTLFPGFHDAHGHILDYGWSRTVANLVGAKSVDDVIQRLEDYVRSKPHLMAFALADDSSHVGLDAKEALPWIEGIGWDQTKWTPAAFPTAADLSRSPLLRRFPVVLRRVDVHALWLSQVGLDMVVRGAKDFPRTPAEDDQVQGGLVVRDDHGNPTGILIDNAMNFAYQVVPEWTDEQRKLFLDAATEGLLRVGITAVGDAATDLKAASFYHAMDAQGLLRFRIYSMLACPPGERRCAHRIEQIRPSSAVGATNHTMFTLRAVKLFNDGALGSWGSAMWDDYADKPGERGLLLIPEHELPSLVEYWLQRGWQVCTHAIGDRANTLTLNAYEAYLRSHPHVTADELRPRVEHAQLMKPGDLGRYSELGVIASMQPTHCTSDMGYVERRIGRERASHGAYAWKSLLRANASLALGSDFPVELPDPLHGIYSAITRLDDSGNSPHGAGGWYPHERLSRREALRGFTQDPAFAQFEEDTAGSISVGKRADFTVLDRNILDEQAVSPIMLRNANVDATIVGGRVVFDRFTAATPSKDRGSSPNGARFEVALRAAREMLQARISAFESATLAWILLIVGGIWMVASSSSSEPYQTLSCLALNVRAPTTAWMNMGYWTPQLSHRELDFPLACQTLAEQLYTAAGVGTGLKILDVGCGAGESTLFLLQKFAPTLLHAVTSLPDEAAFAAERLQLQLAETKQTPEVKVWARDILDWLRTDEAAGEKYDVILALDCAFHFSDRTEYIRLASRRLKPGGRLAFVDLLSAYPAPRDGAAKLQLGPLPFPREAPSLAERLKHTFTCTLASVRPANLWSVDGYHAELVSAGFTPEQVTMRDITADVFPGFARFLRGFATEGAAWRGGGWTMRKGLGAFSNVVRAWSQEGGLVRCFIVVAQKPADEQPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPL4</accession>
    <name>W3VPL4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_01927</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPL4"/>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000058">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1024"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1063"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1112"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1182"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="14">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="271"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1243" mass="138111" checksum="A3EB63EC9F9AE9BC" modified="2014-03-19" version="1">MKLAIQSPEIASISLHKRIPTHLHLYVIPFLSLYPIWAYAYFVKYDEWVRSEEWTFVFTVLLISGHALSFLITKWSIAARALTTCVSAKGLEDAQLVRIHPLLHKGEGAIVSLDRVERSNLPVEISFTYQADKYILATPDPSAAPTDIFVSPLIDVPTFRRLPYPADSKPPLSKFQSNRGFKTEKDVELALGTFGKNELDIPKPKFVDLFLEHAVAPFFVFQVFCVGLWMLDEYWYYSLFTLFMLIVFECTVVFQRLRTLSEFRTMSIKPYNIWVYRAGKWAEMQTSDLLPGDLVSIDRSKEDSATPCDLLLVAGSTIVNEAMLSGESTPLLKENIELRDGKDILDVNGADRNNVVFGGTKVLQTTAPEADSSYAKLRAPDNGALGIVLRTGFGTSQGQLIRLMVFQNESRVTANNLESFVFIGFLLIFAIAASWYVWVRGNEMERPKGKLLLDCVLIITSVVPPELPMELSMAVNASLMALAKHAIFCTEPFRIPYAGRVDVCCFDKTGTITGEDLEVQGVVNCSPGGDSPLIPLKEASAETTLTLASAHALVLLEDGLVGDPMEKTTLEAMDWKLNKGDLLTPTDPKAGPHRFGVQVRRRFQFSSALKRMSTINHVIDQSGNRRVMIAVKGAPETLKTMFAQLPAHYDDTYKGFTRRGSRVLALGYRFVDNVSANDTNAINNMQRDQVEAGLKFAGFLVFHCPLKPDAVESLKQLNDSSHRCIMITGDNPLTAVHVATQVEIVDRQTLILDVREGAKSEQDLVWRSVDESVVIPVKASDPIDTKLFDTYDICITGVAMKQYQDNATAWDALVQNTWVYARVSPSQKEFILNSLKSLGYITLMAGDGTNDVGALKAANIGVALLDGTPEDLAKIAEHQRMERMKKVYESQLSLTARFGQPPPPVPPMLKEKFPDLERAREDALANMNSARTTDRAAKFDLSTITASMADAELDDGPPQIRLGDASVAAPFTSKLSQVASVLAIIRQGRCTLVATIQMYKILALNCLIQAYSLSVLYLDGIKFGDYQVTISGMLASVCFLCISRGQPIDKLSKERPVANILNAYVFGSILTQTALHIATMYYIQRLSVVFEQPEDVVDLEAKFSPSLLNTGVYLLGLSQTISTFAVNYIGRPWRESIRENKYLYYGLVSVGGIAIAGATEFMPELNEWLQLVKMQPAYQVQLVAAMAIDFVGSYILESFWSLFADVKPKSLVTKGQERRVERRKHEQIAKAIEAQTAEQKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPX1</accession>
    <name>W3VPX1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPX1"/>
    <dbReference type="HOGENOM" id="CLU_004196_0_0_1"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="114"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1023"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1058"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1138" mass="126516" checksum="EAEA087192D4ED3B" modified="2014-03-19" version="1">MQNNALSKAAQRDGTIGSSFRLFGLFGLLGTATRNQAKPSKAHLGLVKATFHVEDMHRSSFFPTSLYLPPPPFNLAAQPRRCTTAGPTSTPSMDALVQVFTHSLDPNPNARKAAELELKKVESQDGMLSSVFQIVSSSQLDLAVRQASAIYFKNRVRRHWDVTPVRGGPAVVVIPQNDREAIKSTILTTLVEAPAQTRVHVANALGTIARCDFPDSWPTLMDQIGQLLQSQNPNEVYGGLRALLEVVRAYRWNNGTKMMDQLAPATLPHILHTGNNLLNSDNASSQEVGEILYLILKVYKTSMHTELTKHQQSHESIVPWGTFLLNVVQKQIDPSALPADDDAREVAPWWKAKKWAFHSLNKLFSRYGNPSQLPSDMKAYKPFAEHFVATFAPEILKVYLRIAEANSQSNLWISKKAFYFLCMFFTECVKPKSTWALLKPHVLQLTQSFLFPRLCFSEEDDEMWELDAVDFVRANLDPFEEIGSVAGSAATFIQTVASKRTKSAFMPLLEFVTEVVNAYPAQRSAKDKDGAFHLCRAMDLTMVNHEKVSHMLDGFFAQHVIPELKSEHKFLRYRACDLVKAFDQNGMQWSNTATLEAAFRGVMECIGDAELPVRVVAAEAIGSLIDHDEVHAAMAPNAARLMQELLKLSDETDLDILSPTKSKVVANFGDELLPFSIQLTEQMAESYLRLVNENLETAERDADGTMELNLDNHEDDKLFAAMGCLNTIFQIIASAESKPEILEKLEAVVLPIVAYTIEKDCVELFDDCLELTDTLTYYQKKISPGMWHIFTLVYKSFKGAGIDYLSEMLPTIDNCVSYGVEVVQQSSEYKAMLVDIFLTAMTSDQLGMTDQVAACKLADVILLLLRGGVDEALAQIVGAVLPHALDDEKAKADVRKWSIIVVLDALVYNASATLQVLESANATTALFGAITSLLPKLTRVHEKKVAASAIIQLLALEPASLPAALQSNLAPFLVALATQLDGLPEAIKKRNELLEAFENDEDEDEDETSFASSSGAPNVDTSGYEDVDDDRDVVDEDNEYLEMFARERAKLRARANGEDLDEDDEDDEFDEEDDEDDELSYESPMDAVPVFEQFRALLQSYQTQRPQVWAGIAAQLTPDQMQLIQNAAEGKDERVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPX6</accession>
    <name>W3VPX6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPX6"/>
    <dbReference type="HOGENOM" id="CLU_008722_1_2_1"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="595"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="690" mass="77865" checksum="C4FC4E2907C70B5B" modified="2014-03-19" version="1">MGKKGKPSAGKAAAKAAKKEKAEKQATRKLTKQAAKQKTNTSSSTKQQPGKKGAAVEDDEEDLDALLARYREQWEQEHVVSEEKVGGPPSRRANATFTPCPLGNDLYLFGGEYFNGERVSFYQDMYRYIPEKNEWRTYASKTQPGPRSAHQVAATAAQGGMLWLFGGEFSGARQNAFHHYRDLWAFSIETKAWERIDTKLRPSARSGHRMTFWKHYLVLFGGFIDTGVKTQYLNDLWIFDTQNTFKWTEIKQNDLRRPPPRSGFSLLSCPEGIVLHGGYCKKYVKGQRTQGVALEDTWFLKMDEDLTKLDWVKRRKVGYAPNPVRSGCTMALWQSKSMGILFGGVTDTEADEETMESTFHKDLYGYQLPGTGRWISLNLKRKKKAGGGRRKKKQQQQQQQQRRDEDSDDDGDSDRDDEEQLAESTEKLQMQEKASIANGADEDDDDDPDDPLKTIPLERYNVMLAVQRNTLYVYGGIFEAGNREYTLDDFYTLDLSKLERFTCLKDCPIDALDWAESESDDDSDSGSDSDSESSESESEGEEGDEIPEGFEFDEADSDDEAARHARLSAAEREALRAKAQAFMGVAADCARTEQEVMSTPQPGEKLRAFYERTKPHWAAVAMEADPKLRGKEMRKRGFALADQQYQEYKPILDEIERIRAEAGLDENEAAVNKVGGIGAGSTGVDSRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ22</accession>
    <name>W3VQ22_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01968</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ22"/>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="45"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="198"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="385" mass="41588" checksum="4E4B412FD0B73D1D" modified="2014-03-19" version="1">MAPVADVKHAASELELSKLKENLTLMATSKKELELIKSAPAAPKPGMALVHVRATGVCGSDVHFWKHAGLGPWKIEHQCALGHESGGIVVAVGEGVDNVKPGDRVAIEPGVPCFKATCDYCRTGKYNLCPTVDFYSVPPKDGTLKRYHEHPAGWLHKVPDNMSYEEIALLEPLSVTLQATLQAEISLGTPVLITGAGPIGIVQLLCASAAGATPIVITDVVQDRLDFAQKIVPGTFTYKVDPKLSPLESATEICKVFSRASGKHIAEGEKDVQPAITMECTGIESSVQTASYATAASGLVFVIGVGANFQQIPFMHLSTNEITLKFLFRYRDTWPRAIRLVSSGKIDVKQIVTSRFPLEQAKQAVEHAADRSKFSVKTIIYDDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ62</accession>
    <name>W3VQ62_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ62"/>
    <dbReference type="HOGENOM" id="CLU_010391_0_0_1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1066" mass="116068" checksum="71F84BC6F12D0167" modified="2014-03-19" version="1">MESAGPSSPPPARTRKPGEVRSRSGCITCKQRRKKCDEDFRIRHNGATSCNRCADRGIHCETSSHATPQRAPQQHRASPYPSASSNPNSASKPPSRAVRGPSAVPGGHLSDVTSASSSSAAPTGPSSAHPTGSSVDTRHSAFASPLDQSQAWAASAHFPVQQPLPPQQQPQNVATFAGLQNPAVMNQLAWMNQNAAALNRSAIRYNRPNIWPMAASNGGIDVAAAANAAIVAQNGTGSAPAQNGPVDMNALMNLFNNSNPAGAAPAPSQQQWPQGYSNSMDNIMLDDFVSELMSLTGPLVGGDGTSLPQTSDNTPMAANQSSPAPLRTASRASNETAPSSSSANSSAQRQNLNASSASSVPSSRQARPLDSKSPSNPPSKTSNAKASTPGRVSNRYRKLLDSDAIESLLSKYSPIYERFWHATLMLLSNKKKQAAVDYLMSVIRSNKACRASVVVVCLAYHELVQRVRKGAQSEHAKASLQQGVPPSNWTSVATDAVHNGRAVDTPEGSMSHTIMTMIPEDTDQDDRRSSRTSRPSRHYALSRGDSDAEDNDGDEDEEDDDAMHTEEEISTIQGRSGSDRRFTQGTTRHSSEVYGSTSFSRRSDPGQRPTPSAGRNLTGKLSTVEDNIQEMDDPSRDAFKGQKVEEYTVELWFDIAQAELQRSRDELTLDQELCAIINLRWACLCFAGAERARQLTEELGVVMQREGIDMDHAAAEEKKGSFVSVMLLTAVYTDVLDTVSDRGKRTHVSLRTDARAARPFQPRRASSSAMGKSASADRDEPFFGRISLISLELLTCFKLISDLAADVWGPISSAVLHPTRPSEDEVAERSREIERKVMSLPPWSDPNTSSSLRVRAFALQEIWRQTARLYLLQAVHRRGPLHPELQNILHEIIRLAKMMKIQSFSPAAPTFTGGAVAAQRYPSQATQRSAPANYIGGLNSADPTNDVRDANHPDPIINATYGMDDLDEPLQPDDDEDGPGPAPFQMWLDVASWEMCTVWFLCSTVALTRQDRQFCIHHLESLGLERANRDNIQVIRDYWAKQDATGHTMDWFDFVKSSGRSVIFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQC4</accession>
    <name>W3VQC4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQC4"/>
    <dbReference type="HOGENOM" id="CLU_035750_10_0_1"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22676" checksum="6031011CCB4F04B2" modified="2014-03-19" version="1">MSIMEYNGGSVVAAKGKNCVVIASDLRLGQQAMTVACNFDKVFRVTEKTYIGLPGLASDVSTLRERFRYRVNMYKMKEEREIEPEIFANLVSSTLYERRFGPYFIEPVIAGLNSKDEPFIAATDVIGCLNFAKDFVVSGTASDKLFGMAEGLWEPDLGPEELFETVSQILLGALERDALSGWGAVVRIITPDKVIERTLKARMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQC7</accession>
    <name>W3VQC7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02761</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IUNH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQC7"/>
    <dbReference type="HOGENOM" id="CLU_330410_0_0_1"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000152">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="13">
        <location>
            <begin position="62"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="540"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="652"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="770"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="868" mass="93767" checksum="B7EF7E0AAEB37780" modified="2014-03-19" version="1">MLRASPSIPLQRTSQQLGHRTHRRLPSPRINRLHLAVQADFLRSPVPVQSHRRPIMTAPIPLIIDTDPGVDDVLAILLALASPDEVSVKALTLTFGNTTLDHAYANVLRTGATLHRHLADPSTPDAVKARYRSFHADAEPIVVASGSTQPLEGKMFTASYFHGRDGLSGVHWLPNDPFPVPEKAPAPLSPTDKHATDVILDVIRAHLPHTVRIAALGPLTNLAAAFRKDPYTFAKVGAITVMGGAFDVPGNTSPVAEFNWYADPYSVRVLIDEAPRHAALGGKRLPIQVLGLDITSHHTVPYSRLVKATYETPSDVPEGASHLERFVGTFLTHPRAFTNNMVAPEEFHPDKHDLFQAHDPLAVAHAIFCPMPGADSAAQTNHGWKHSERRFQIETSGELTRGFCVVDRRFVGANSSRKAGHNRAEDADEGINGLHVIENPDIPVHKLAQPDKPVTSNEPEVGLVDEVTETPGTQWFAQMFLERIGVLADASERVRLGREPEKAVPTFSEPGPQRYLERHPPRNTILLRTTSFSDFSAMSDDSFIHACAGGVGGMVAMTATYPLVGISTRAAVESSKNPEEPMVKAALKILQQEGVSGLYAGLSSSLIGIGVTNFVYYFFFEKCRESILKSKAKVAAAAATSATATIVNGGALTTFESILAGLIAGTATTVSTNPIWIVNTRQTVRVGSADPKADPKAAAAAVKRLGFLQTMQKIVREEGPLALWKGLGPALVLVINPVLQYTAFEQLKNWVVKSRLARANGGKVSLSDWDFFWLGALSKLFATGLTYPQIVIKSRQHAGASKGASTNIWTAMTEIVQREGIAGLYRGIASKLLQSVLTAAILFASKERVFNITKALIAPVAAAAPVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQH5</accession>
    <name>W3VQH5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQH5"/>
    <dbReference type="HOGENOM" id="CLU_024327_4_1_1"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="402" mass="46774" checksum="A194D6F944678BEC" modified="2014-03-19" version="1">MNLTLRYIALAFVSILSLHYLASYTSVSYQQQVDTLRSSWNNNASLHDAQQAAQTAGLGFEATPKANASFVVLCREGEINEILSSLQHLESTFNDRPHHRYPYVFLNDKPFSDNFKLRITRAVSSSVEFGQVPPEMWDIPPEIDMVRARKAWDRAASRGMPYGGSQSYRQMCRFQSGYFFRHPLVLKYKYYWRVEPNVKFFCDLTDFDPFRFMQQNNKKYGFVLSMHEIPGTVPSLWIRVREWYEKNAELLAPNNLFGFVTENNGRGYNKCHFWSNFEIADMDFFRSDAYLSFFKHLDQAGGFFYERWGDAPVHSIGAALLLDKSDFHYFDNVGYFHSPIMHCPKVAKESAISPYLGRSRCYCAHESSFTFDDNRQSCLYNYLEIMGKNSSAARNEFMKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQH8</accession>
    <name>W3VQH8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02023</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245177_0_0_1"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000022">
        <property type="entry name" value="Related to glycinamide ribonucleotide transformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="714"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="856"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="513"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="656"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1455" mass="152882" checksum="7BDAA3362C71A052" modified="2014-03-19" version="1">MTFSHHHVSSQRTPNASGPSENVSSASDGTSQDLASWVDQVRQRSSASATSSNQGSSGLADTAPTSSASELEQEFQRQRLERQQRRDRLSVSGIRGISSQTNSPLATPSLDSPSFAAAVMAPPDASQSPSASPLLGASPPKASGVTGIKRANSLLARYGGQYGPTGIAAGPRGPNESPVSLANFMGGKAAGPRLGKLAGDGKSAPPEAELIHESRRVPLPGMSPHSGRSLASFLEERADASGKRRTGDGAPASPVKDSPTPASPTKASSSPAKYGYASAELGRPLRTATDPPSYQSGSSGNAASTRPASPKKAYLELMEKQNTPRTSAPPSPVIPRASSPSKFHRFTSAESASASPLLDRPASPLKGSLAPSPVRDESVGIAAPNHSTSRPLPIPKAHSSSHAEAHSTERKDAATSPFKPEDIVDPSVAGVVAAARAQPKPDGGLGRGWTQSTGQPDTAASQPSTRSDSLAANELSGADRIPTASLSRLSAKKMVGQRIKEAQLRDSFAQKEYDAMQAGSAGRSVPSSPAVRDRWPPAVQTNMSPVRSNSDERKVGSPWSPTKYGNALPGLAGRSPTKEASSSPWLSSPSKKMETTAEPRAEPIRLPGMGASVSPFARSADRNVTTDAATIGSNVDVPGQGTSTADQVLAPLTKARAKGPIRRGAPAEAKASPSPADTKAAPTPSAEKAAITPAVQESSKPVSAPKPPRRTSGKRIHVLVSGSGSNLQSLIDATLLDPPTGLPTIENAQISFVLSNRKAAYGLTRAAESNPPIPTKVLALKTWQNRNPGGTREQYDQVLARAVLDGPYPEGTGAPPDLIVLAGFMHIVSEPFLHALGHTTSLPANTPTVGARPAKAVPIINLHPALPGAFDGANAIPRAFEAYQQGLIKKTGCMVHEVVADVDRGRPIIVREVDVLPTYKLEDLEQAIHKVEHVIIVQAADLVLKGHLEELDRQEAATKQEKAAAIAPASKPSPLEIVELGSELAGGEAIAAAPSIVKAARSAIAKHATLADVVSSSHTSAASSNVKTVSVEVLAIDADGFVEALEFSGDQTFQRSEQLRREQILYDDETLAVVKRFKTDAGQTETKIWVRTGQASALHPFEYGPRSTSCAEGRKVQELAQGYACKPEMIPSGCEPDELIASLSGTWAISRHGSRKRFDAAASSLYRIRAAVGSSPGPGQRFAIQQVELQTTNLCSGDSFVFSMLSSLGVWHGRGASTAVRAAAVRFAQALAKSGSSGARSSEGMVEMEEGSEAALFSNVFDKSQEYASAWFHRQDKGARTDAASLVDVELRGQDLQLQPVTSNGYFGAHDLLLPTRSTKISILNLRDEELYVVVGRDARSDRPRLACAIQAAEMLAELLQAKLRRAAASEGTVVARPAVHVLVLPSKVPREIRAASRVWSDKMAEYLQGEAPGRMNVCSSDSAMEQLGKRSWPRWALSDASYLPIGVSPEDVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQN1</accession>
    <name>W3VQN1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02302</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQN1"/>
    <dbReference type="HOGENOM" id="CLU_042324_0_1_1"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="49"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="436" mass="48015" checksum="9716070799A3A891" modified="2014-03-19" version="1">MDSGSSATPSGTMGYELPWVEKYRPLNLDDVVGNKDTIDRLKVIQNDGNCPHLLISGLPGIGKTTSVLCLARALLGDAYKEGVLELNASDERGVDVVRNKIKTFAQKKVSLPAGRHKIVILDEADSMTPAAQQALRRTMEIYSNTTRFCFACNQSNKIIEPIQSRCAILRYGKVKDEQILKRLLEICEMEKVEYTDEGLAAIIFTTEGDMRQAINNLQSTWTGLGFVNPENVFKVCDQPHPFLIRALLTACQEGDVDLAMDKLDEIWAKGYAAVDIVTTLFRVVKTIDRIPEATKLEFIKEIGWTHMKILEGVATVVQLGGLIARLCKLVSAPPLSPTYQPALANLACLGPTEHRSKAIPSLIPSSTNVAAALHYAAILYFYTSCNLFFSPHTFLGVTFSGLQQDSSIDIKGKAGFRTESQEGANESKRNNEKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQS4</accession>
    <name>W3VQS4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQS4"/>
    <dbReference type="HOGENOM" id="CLU_264022_0_0_1"/>
    <dbReference type="OrthoDB" id="2552362at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="926"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1132" mass="121388" checksum="A531F53F3B7536D2" modified="2014-03-19" version="1">MTSPLRSFARDEASVTSPYRHPFAASPSPKPSHSPFLARRSLTGGNRTSKHSRSSNDILSAPRPDLASKPPDAISTSSSTLVNADTTSDYRPWEVRSSSSDSSLASALLSVDGGATPTLSALDEVGTLPSIHISPLPARTRPRPKGSDRPAVAASPRRSRPRQVCPDDCRCSDQDIDLALCRRAVASSSSGSDPGSLSVGMHPMRPRNTTSDAVIADAEEALNPGSAPAYDQSHNSNSASEPRSHSRDFEKDPVLVPKSARARLGPRTHQNSFDQLQRGLDTLESSDSADSDAEHSRAVQRRAESMARWTARRSSTEVRSQSNGRRSPVAAPVAADTPSPARPSPVPSPSRRTPQSRLAEESIEASFATPLMTPGRKSIAAVFESMQKEREARAAEEHRQWQEKQARRERERAARAFVPSRRRTSATSSQFDSPASTSTVPERASPDWRTPATRSPVSVSATASPLLSSAGSPKIDEHAASDVQPRHLGEEASARIPDTLAEADEDEVSSANGQVQDADRSQEVSVGTRAVDKLPTTPQTQQTAFGFASQPMALDLSPARSLSSVSSPASSPRKGAHRRQNTNTVSVAANLPSASLGAARQRLNHVLRSNASAPDEQDSHLQAGQEYPQTPINSILSSARKGPLSAARRGHSVRFSPRPDYRSDSGSWDESTQAAGNDEGDSREAAVTRLLLPAQPIRIPDILQAASIAAPAEPNNEHVVAAAEAVERVGGLHTAAKVEEPEAAGSFSQSVRFPGAYARTPVKAKTFSRHIIRASPKTERVLPPAMITTPAAVQGEYGLFPESGAHIPRESTPPPRPFLPPDDPRNSPRSPRPASLGQEFASFETGTSDDSGGSNAQDLRGGGGDESLQATVSKMLSTMQAAHEARDKRSRLGEAITAVGERVRRVEAVRQPEGNSPTARLPRDSRAALEATIKAEEQDRKRIEELRAEVAQALAVLADRIVRLQAQSPNHLATQPLTSAKPSRAKLRIVAVAVVQCMVMAYLMALAERKAHRMRMFAGPSDLRHLLNARSNIEWESSAHDIHLTPLLAIPGLAQLANAFPPLPSPSMLRLIPNHPATSVSQIYTAYVRINGFPTFALQLALYAIAQLIGSMVILLSAPIHVLWYIANPSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQU0</accession>
    <name>W3VQU0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQU0"/>
    <dbReference type="HOGENOM" id="CLU_115051_0_0_1"/>
    <dbReference type="OrthoDB" id="3366194at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="175" mass="18980" checksum="E0133555CC2F4A09" modified="2014-03-19" version="1">MDFVAVAQSLPHPELPHSERVASYGRVMAGARLDARVPSRVQASPSFIATLARVHATLQRTADDEAQLCNVAWPEILSKLHAALETGRPITGAGQGRGLPLDVVVATLKASWHVDGTWPIGPNAKQMLEQQAQQRAQAEKGPEAKQDPGPDDIARAYRARGVHVDEPVFVDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQX0</accession>
    <name>W3VQX0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02177</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQX0"/>
    <dbReference type="HOGENOM" id="CLU_042174_2_0_1"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="391" mass="41798" checksum="B20696CBC384EFEA" modified="2014-03-19" version="1">MSAPVAPPQATAYPPGVQAPPPSGAERVGPGAPSPFVDEKRAAYPSGLTPPISSQPSTSMFGFFQPIVAPLNNALATIQDIRTRLELSNPGTVEHLQREVKGVHTTNFMFDGARADLTKAISINPIFQVTHAFSMGSQGAPSSYNFGAVYGDNKNFFQAGLDDGLNVTMRANRGWVAGHTTKVQAQLTATPGQSFVQVEHDYQGTDHSANLKALNPSPTDLTGIYIVNYLQSLTRNFAFGVETVYQRPSADMEEASTGYIAKLTGDKKDWIATAQVQPQGVAQCTYFHKLSEQVDVAADLQVITMAQKREAAATLGARYNFRMATLRAQIDSAGKLSSVYETRLSPAFGLTFAGEIDHLQGAAKFGFGVSIESGNEMDPNAPPPTPPSVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRC4</accession>
    <name>W3VRC4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRC4"/>
    <dbReference type="HOGENOM" id="CLU_380908_0_0_1"/>
    <dbReference type="OrthoDB" id="5577218at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="839"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="879" mass="95272" checksum="AFFE9347F6D044E3" modified="2014-03-19" version="1">MQEKLSAIIWLLPASEKFREKAASKLDFLRCAAAAAAAAAAAVCAFSLCAPLSRSASNLQPLSQPGHHPPLLSASPPSFCLRRIPTRHTPRSLRARYPQPHRSNSNSPAPPCFDNPPHPARPTQPANDNVQPSALNNRTFTHVRNAAMSYLGTLAVNFGRVATFIQVLFYLPLALDIAGQDAFLALSASLASYYLFLSTVRLLTNGTRLAWIGQTLAVFQFVVVPACLLVCFNVYSPPSATIFPPRRPDSLDKTASEAISSLFTRSSSRTAHLDPDALDDLHSLTGVAWLDHLVSASVAFFFWLARRVPRWWHTLLRISSPFFSLLEGVASLLVIQSLASTSRWIIASLLEGVASLLVIQSLASTSRWIIASSLAAPSARYPPRAAARGQSQPKSAAWVSNTFIMRSLASIGFGASEVWQIFFLLVSATIYVTAAFALYVSFDGATKDRPGTAAAIATSVTSTLWLTAIAFAMRKGNVIETSLMFAYVVFNIYQLGPSLSFTPDPISLIRSFKVDTHARTFVDKLPRSLQASLTGKLLQAASGLVEVIAHWLGQSVDFLHAAAAALPKSVIVSLVYRLMVLYAASRILPMLKGSVAPREPAEREHIAAQWGRTSRQAGEDESDWSSSSGTESDSSSEEGTEVEELEEEVWDDDEGRWVLQRRRLRRRTRRRTPMDAAVDTESESDTDGAKYSEDDSGIAYHEPSLAEQLKEPEPGIEATLQSAPSTAPRGAGAGRTRGKPRRRRRGAPRAPAASPPESTHEAVGESSGVRKRPSMSRPPSARTHKRARPTTPTRASPHAAAAAETPPFGSAISIVVSYSRLILIAVYSHLLLLDQANQIYWRFLTVAITLLLWGLEIVIATEDVVVGGVGELGSAAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRZ2</accession>
    <name>W3VRZ2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRZ2"/>
    <dbReference type="HOGENOM" id="CLU_326547_0_0_1"/>
    <dbReference type="OrthoDB" id="3364994at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="965" mass="102312" checksum="8A823B1782109CAF" modified="2014-03-19" version="1">MASAPTPAPYPTEPLLSDRARTNIGAALDPRSFSALSSPSPSPSAYAPLPPRYKPPESTMSSSQSIADNPKEYNKWASAYSKRLGTASTVGTSRTALGPSPSDAHQQAHAARSLRQRVPSHPAAMPARPADLLQSRVFGLTADLREPSSTTTSGPALDDTNRMARMLGVHRPNFSVEIFSTSFDHRGYPVYSGRGTSVRGVVRMPATEGCDVMMTISAHTTSGSPAAVWQGTALAPWSTGGEKKVFEIKDRLVANYDLVRPRAAYAPKNEDLMEPPQISKDDLVLPIPFDVQLPLGKATRFIDGEMQAVPVALPPSFEISSKFAAQEKREIRLATKGKAKGPMAKELIEKGFQKVYRIGCYYQVSWTLIRSNNADKSRKSPSKSAQPAEGDTLTLPFIFLGEPTPMQPHPSTLPSTISPDVFVEPDTTLGDQWSIHKSQAKWSGSLLKSSKKTVDMELHIPNPPVLQAPSVLPIMLVLRPTEPTLLSQIRTRAPSETSTAPGSPAVTQTDDPIEMVASPVLSSGESTAAPSMSSQQTMRDADTESIRTTRSLVSKLMKPSMTLSRLPGSSSRKGGSSIFGGRRPNTAPSSGSSDTGLTDAMTDRTYVAAGAIPDLVSLVCISLIQTTFSSNDNVNDGPEQRRKLLSVADLEEVDVHALLLSSDSSGSQPGSRPGSSRSPDEMAQINAAAAAAKAAGVRVLVGSLKVAGTTPPNFRCHGLEVKYALKVDLLPANRYSSGEGVEKALRNLGLGSGRSRGFSDGASTTASIHTQTQFTSLSGDGSSPPTTPPNMMSPSLFGSRSPGMDGHGPSARAWTRQTGSRNASPLGAGTGSSNMQNVGMAISTHDESAVSADTPEAQELLSPQLEAAAARAPMVAAPYPSAFPQHASQHAAGRATPSVYGSQMSSAASVRTGWGSGHSISEASQMQSSIYMSEWGRDRKTVSKINKTIGEMWLDVRVVRAHNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS39</accession>
    <name>W3VS39_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS39"/>
    <dbReference type="HOGENOM" id="CLU_298465_0_0_1"/>
    <dbReference type="OrthoDB" id="2549520at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1007" mass="108194" checksum="4D77E86E9177D223" modified="2014-03-19" version="1">MTFTGLPTAALSACTRDPTSSQPHRFGEVTGSTSSHGSSGLDDYKVLQPGDFARMKGQLSLRSRPASRIDWVIDSDQYNAIAASPGVPNLLHDASPLPPDFDLVLPARQHHLHDQATSNRATFGPWSDESEHTHEGAAAWADAKEDLLSVADEGSDTDAALQTNDTALQSTQAQPAAAPLSAEEETPQAVKQDTHLSQLKMEAEAAWANYRPGLRPLISEHESLASTSSTPGTPAQVPQRLASLRRSSLVAHAALAKPQQGSNHNYSASHSSISLSSLAHDTGTPSSLHAKLEPEYVPHPARPFGRGSLGSIRASPSEARFQRPYTASILSSTSEGSLLSYQNSFESGLSPLLLNRAATSGRLHGRSQRPATAGSITVSAAPLRDLHLPRPHLSASSGRPETTNQLSAEERRQQVRRTKKLAQMLGEEMLFATNAHSQQLDPAPRSHSLVASPADGRSRKHRPQSMPFSATGHVDAPGTFASNAGSKTRAFSRKLLHSRTHGVKSWDHASSGLNQNAVYLNLNRKAADVLGIPHPYSSNARANVYAGDTFSSDEELNRVEEIRSHTRPFVPSGLEEFNEPTPKVDQLAAFSAAALDEAASPTLPQDGPFRPFDRSEIDQALAVSESRKLAAARDERRRRVAKMSRWLGEAVPAELISSGTKAGPGAVIVSTGPSDPARFGSPATTTSDAHSLCGAPSSSACQPSSRSHGSISHESSVASNLHSFMSIDSSDEESGDDAAPTIATGRVLTDVRLVASSPRSRASERVAASDSLSTYRNSIESYEYLLENDRRRLGELASIFQHGRSAPRPSTVDTISARSRPIRPNGRPQTSPVTGSMPDGRRRGFQSLGHADYESDERPPRPSAAFLELSDSESDSSEADELPESDDASSFPTSRRQRAAHLHDRSISKLSNFFGSTPSQIVRSQSDMRVATSSVDSVSTVGNGSLNSRPARGGNGMRSLSQPEALKTMLRSLEEEAMDDSKLNPFQKSEISRRVHRLKKRTTKIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSD6</accession>
    <name>W3VSD6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSD6"/>
    <dbReference type="HOGENOM" id="CLU_011276_8_5_1"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="181"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="310" mass="34095" checksum="F6087099E9368308" modified="2014-03-19" version="1">MASRNPSKCPMQDEAERYPRLCPGGGLLIAWQLKGKKVLIVGGGPVAAGRLVNVLDADAILDVMCPSSGLCDEMRYRIYTEKVVSNYVDANYDEAHPEILDQYDMYDMVLTAIDDVELSKKICYECRSRRIPVNVADVPPECDFYFGSLIRNGPLQVMVSTGGQGPKIASQTRQKIQAAIPKNVGQAITNVGKLRAMLRKRAPSAEIGARRMRWMIEVCEKWNLDEICTMTEPDMKKILDGWETGYVPSYKEVKGGLPFLPSDVRLKKALFGTCPVVGYPSPYLTGFAGVLLGAAVTSAVFLSRGLSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSL0</accession>
    <name>W3VSL0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004538_3_0_1"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="694"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1250"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1467" mass="158858" checksum="7C5C247E548A230E" modified="2014-03-19" version="1">MTAGARSNVTHREEGQLRLQASERIRRRAKPAKLAARPAERHEKFGRPVHRHWQAEPQNPTRRLWHSSLQWTRDSIQLDKLSIVRSLQREPAQQRVWLSSHPIPPLSPHPPLSNSAGSRAAPPLPPPPLLHRPSTVHPAIRSQSRSKRDSSHACSSISTISTGQHSHSRLAAAEVHQSIRLHSHASSSPTNPLHSHPQASAIARRTHTTSALPSSPPDHITPAATLRQPSAVTRSKPCFICIRTRSHRSSSKGRPFGASIAFLQSNQARPSQLPSSSLSLRFASADIAAGTRHRIRFALRAPRPTMNTPPKFSHSRQGSVDLPSSSSAAHLHHPSLSGHPPSGSHTPGHHSPLTTYGHALASLAYPTSSYSPYRSAQNLPVGSWASSNPSALHGSTAPSSSKRSQSRDADDDDDEEDDDDDDDDDDGDSDDSDDSDDDDDEDDDADQTNDGKSKGANNKRKRDASPKNASAKKKANAKDKQGDKSGGANGTKDGATGQKKQKPTRGARACTNCRRLKMRCVGAEKGPPCNRCRNGNHECIFEESNRGKKGGKNQKAEAMQQSLRKMEQTLATVLRSIRDPGLAAQHGGMHGTHASGSPARVSNDGTSPISTINPSAVAHRSASSTDGSTHSPANAHGTRFLEPLPHHHRQQSRPGPPGSEPPRSRPSRGSPRLHSLPDNTLNPLGLLAEASLHNTQRARKHAASRSVASSASREKDSQRSGSTGGQSPDKTIKSEGGEDTTPEGDANAANDDAQRKIPLGVASQNYFRPGPMTILPLRRIIIEREMPPELLTLGIVSSEEVLDLFSIFFRRCTQHLCLLDAEWHTPTFICSRSPFLFTCVCTVAAKFYDRRPDLHAKCMALTRKVAFDVVNRGFKSIEIVQGFLLMAMYAQPAERFEEDKTWMYSGIALRMATDLNLHRKSVATFNHSPHPDDPAVLDREREILNRERTCIQMGKPYTIREDWIIRNCRNWGSRFSRPWDLSVSAVVDLYRISSRQLDFLYSSTSSVSGLNTEIDYSLVLPVFNEQLQEWREEWRWRGLFSVPEEGEEYIENKRRKKAAAAEKEAAAAAKDGDKDKDKDTNGAAKTSTTAAAYEYEDDDEDAENLDLNTRILIHHAHSVPVRYSFAVLVLNSFGLQQAVDHPTGANLDRAQYFAKCLEAAKTIVTNCCGPSRRNMRYAPDAHILTLAYACVFLLKLIRPAFAGYVEEESILTLVQGAVDMLEEVAVNETHTPYLYSAFLRALVQARRDHTSASKSAQGSRVVSRAVSPEAMDQDAPDAASAGAANPPEGVPSSGVAEGTIPAALDPSHADFTGSAEGNVNWPSQIFGATSGMDDFWGSLLPPGFSQTSMHDLFGAASADGPGANGHAHLAAEAEVVEPSQHATKFGMGGGGAFDFGGGAIGNGNGGVPLNSAAASAALANSMSMTPVASGHFSGANTPHGLGSRSRRTSASHFNLGGLSNVNFDFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSL2</accession>
    <name>W3VSL2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02068</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSL2"/>
    <dbReference type="HOGENOM" id="CLU_085752_1_2_1"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="170" mass="17384" checksum="1DE902BF6FDA7B2F" modified="2014-03-19" version="1">MDPSNINTELCPVYAPFFGAMGCTAAIVFTCLGASYGTSKSGVGISAMGVLRPDLLIKCVIPVIMAGIIAIYGLVVSVLISGDIKTPMSLYAGFIQLGAGLSVGLAGLAAGFAIGIVGDAGVRGTAQQPRLFIGMILILIFAEVLGLYGLIVALILNTRSQDDPLGCMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSQ7</accession>
    <name>W3VSQ7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSQ7"/>
    <dbReference type="HOGENOM" id="CLU_1171054_0_0_1"/>
    <dbReference type="OrthoDB" id="10388768at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833358" evidence="1">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="237" mass="27360" checksum="5CC5612EFE81ABB2" modified="2014-03-19" version="1">MRVLFAALVLAFILGTTCAQESVSDKQVSDGYDTIHQLGKKHDLSAIRVKKDGTYEGKRRGDGQVMQVDIPLDPHVLAEIKRRDARRIEDQSKLQANLLQPPSKDYLIAVCIPTICQFESDICSRLISSYIKRMGNDRSFRGPVVQQEPVRVRVDTWIRMIMDRRAPSMDWDELERAMRTEMCYLLDGVVRSSIFRVPCVKFDDQFLLRMLPSYGGCCLERISEFYDRMDADYNARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSR1</accession>
    <name>W3VSR1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSR1"/>
    <dbReference type="HOGENOM" id="CLU_1273104_0_0_1"/>
    <dbReference type="OrthoDB" id="2556631at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="186" mass="19135" checksum="F010DB668E8E15C8" modified="2014-03-19" version="1">MSYYPGAPQSSYPGGPQSSYPGGPQSPYPGSQPSYGGSQSSYPGDPLSSSSYPGGPSGDHSQPQYNSQPQYNSQPQYNSGYGSPSPSYSHAPQQQGPMQYDQNGNPIDGERGLGTMAAGAAAGWAGNKMTGGHMGGFSSMASGAILAQVGKKVFEKFDDKKNHNNPYGGHHGGHGGNQGGFGGFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSY3</accession>
    <name>W3VSY3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02241</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSY3"/>
    <dbReference type="HOGENOM" id="CLU_003824_0_0_1"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="769"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="882" mass="95329" checksum="BBA66AD8D2550447" modified="2014-03-19" version="1">MSTFFQKQQQVAALDPRLGGLMASAGLYNLKALIKAIRSCKTLADERSLIQKESASIRTAFKDEDPFARHNNIAKLLYIHMLGYPAHFGQIECLKLVATPRFTDKRLGYLGIMLLLDENTEVLTLVTNGLKNDMEHSNMYVCGLALCTFANIASEEMSRDLCNEIEKLMGSSNTYIRRKAAICAMRIVRKVPDLIDHFADRTRQLLSDKNHGVLLCAVTLAIEIVRQDADALQDFRRAVPLLVQHLKSLVTTGYSPEHDVSGITDPFLQVKILRLLRVLGKENAQASEAMNDILAQVATNTEASKNVGNSILYETVLTILEIDADNGLRVMAINILGKFLGNRDNNIRYVALNTLSKVVSMDTNAVQRHRNIILDCLRDGDISIRRRALELSYALINESNVRVLTRELLSFLEVADNEFKLGMTTQICLAAERFAPNKRWHIDTVLRVLKLAGNYVRDEILSAFIRLVCHTPELQAYTVQKLFSALHHDFSQESLTLAAVWVIGEFGDVLVQGGNFEDEELVREVQPKDVVDLLSSVLDSPYVNGHIKQFVLTSLAKLHTRLSDSAQQSRIEQIIGSFESSVEVEIQQRSVEFSSLLRRSDIREGVLESMPPPEIKQTVLGTVSEAKPVGSTRTDKDALLDLMGDEMPVASGGASASAGASTQQSTQDLLADIFGASDMGGAPAPAAAPAGRPAQKAKSSVNDILGLFGDGGSTPVAPAAAPAAAASASSAFGGLDLLGGLDGSSSSPAPTQAAAAPAPAAAPAAPAASSAKAHTVYEKNGLKITLTPTTNPARPEIVNITARFTATGGNVSGVNFQAAVPKTHKLQMQAISNSDVVPGATETQALRVMVPNNAPVRLRLRIAFTVNGQNIQDQTDWAQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSZ2</accession>
    <name>W3VSZ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSZ2"/>
    <dbReference type="HOGENOM" id="CLU_120161_2_0_1"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="110" mass="12011" checksum="3A1FEACD5867EA35" modified="2014-03-19" version="1">MTLTSSTSIPPASLTGETPQYLIFFSSGNPPWCPDCVDAQPAINHVFGTSADAHLVLVDRPDWKSPDNIFRTQCGIKCIPTITKMINGKEVARIEDAECKTIDSVAKFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT57</accession>
    <name>W3VT57_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00671</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT57"/>
    <dbReference type="HOGENOM" id="CLU_012383_2_0_1"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834851" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="7">
        <location>
            <begin position="27"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="796"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="371"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="610"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="831"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="907" mass="97491" checksum="9CA00EA69966222F" modified="2014-03-19" version="1">MRLSAAHRWLAALLLALVLAATPITARSRQSGPLQRIARTSNVQLEQIPPSFTSAIRLQSRASSANQHPLRLSFRAFQQDFHLHLQPNNQLLHPDGALVKYYAYNETTGESYVRSTQTLYPGDVAAYHGVVVHASHTRRRLEEDRAGFARDIYRDRDFGVVGRASILLHDDGSVSGQPVFEGSFDWFGNVHHVDTPRSYLAKRQADDPSLEPRSQNTASMVVHRDSDISLEPRDEATSTTTFSNFTQSMGCSSDALSFNSHNRLVLSDDTNDATSRSVYSFFKMPAPPRLARRDLFSGWNDLFTRSLPDDLIESSQASPDDFVYHEDLDDYLEPTFRKRQATGNDIGNGSNQTNSYENVIGSTAGCPNSARVVYAGIASDCAYTQRRGDQDAARTEILNNMNSVSNLYRSTFNISIGVVELDVRSGNCPATATQDAPWNIGCGTISIDERLSDFSQWRTQQPGNGIGLWHLMTACNSGSEIGVAWLGTVCMTTGSSSSGQTVSGTGVSSITQQQWQVMAHEMGHNFGAIHDCTNGCTSNSNYATQQGGAPCCPLSASSCNANAQYIMNPSSRANIQSFSQCSIGNVCSLLGRGLDTSCVQTPGARSTLSTQQCGNGILEPGEECDAGPNGSRCCTSECKLASNAQCDPASSPCCSDSCSFAPSSQMCRPSVDSRCDTAEYCTGSSAECPADQTNEDGSSCGNGLTCANGFCTSRDLQCQQASTGSISFRSACSASNANSCQLTCQSPTSRNQCLILQQPFIDGTSCGYGGRCENGECKSGSWQTTFRNLYKDNLRISIPVTIIVGIIVLLILWAIVRRCCCSSRRQRGVGGAKASRASRGPNMGYAPGSAYNPVATPQSTGSGSNAPNGFAPPPGPPPPARESYRPSRHSAWVDPAAFNGPPQPPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT65</accession>
    <name>W3VT65_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_02342</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001996_0_0_1"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="733"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="518"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="951"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1346"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="953"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1350"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS64006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1411" mass="157985" checksum="9BDAEEAF03C922D3" modified="2014-03-19" version="1">MSMRDRQAGVRCSVLQRHFAEVVPLLTLIHDRFGIDASTSSSRSTPDLSEERWACLDGTVVGLDQHASDASQSRSWNAVISSSATSHHTIYEAVQEAQLQILSLTPARVTTAIHGRPTASSNILLKGYRRPDDRLESFRITSTGRPGLINLFPNSMVTNLVLEKEWHYLFHKIGSERFTWLLVHTSIFVPLMRNGADGTCFVQLTGPALSEPATLKTTSDEQAHSRVNGVPELGQDRTNLLAQKQDKTPEPPVEVETDCAAEAAVPDAARSLKLGKRARGFKRTTSRLSARSAASDADIGASAANAGALARKPTEIVLVRSRMFYARSSRNKAGRVEIGLPSVHVLPRSGCAKELDKVLPNLTQSSGTGQHTASNKISLLRKSRPSPDTANEQKRGYRDADSIFTARRTRHLAKYVFPRQFGLHNVFTGARDFDTTTQPFRDYTVREAEIKTLGAKRTPKAVRSALPILAKILVRHDRLNYRALLDRCCPSRVPKGRLTAQERKQIVEDLAEIETLQAGAHHSTARDVATERHPRTSGPSGVLTDSAHTNTPSKGKTTSMTPKLKVELPAPAARKPRYHNYAVPTTGQVAHFAKLAVKSLLPRDLFGSRHNQNLIFDTIGEFVRLRRFESFNLHQIAQSFRFADVDWALPPRASRKRRLSRHDAEARKKIVLEVLYWLFDGLLIPLLRTTFYVTETAAYRNRVLYFRQDDWHVLSRPVLGQLKETLFEPLTRAEALAMMSSRKLGYSHVRLLPKETGVRPIVNLRRRSTKQVHNAKKIDQEEGKSKSKRARAAAVPTAKQRKESLMLGQSINYILQSVFHVLTYEKSRMLAASTSRGHTLGDETEQMDVDMLTSSVFGPNEIYTQLKTFKQSLLPETRGTKASGSSKKPSKTAEKKLYFVKLDVRCAFDSIDQAKLLGIIEQILRKGEDEQTEGYRIHRFAKLMPSAVHEPRSAAAHASGANNAGAAGAVPSRAAHPRPSGTKREFVRLARPDSEHIDFIDLASSLAVSLHDVVFVDNVSYRYESTSLILKLLRQHVTENLIKIGKEFYRQRVGIPQGSSLSTLLCSFFYAGMEAQDPFLRSLRNGGTSDKKCLLMRYTDDFLLITTSKRQAKQFHNVMRKGHPEYGCFISPAKTLVNFDLVDPMMAAEVGPLVQRTYGDEFPWCGLTINTRDLGVSTDLTRYAATDMRDTLTVEYCRRPGVALVEKMIQSMKSRCHILFTDTALNGDDRVYANVYTSFVVAALKFSAYLAELRRFGITFTAEYLLKAIRRLVTFTSRYIGSRAASATAKLNPTAKGDKNVRLGRCGKRAAAWRVSCTVHAPYVHWLGYTAFLDVLRRQDLSYRPRRRKTATEEEKDQHSPYHRSMDSDTRRALVKLVDACVRRTCSDASRRRLSSIAAKALQQAQKSLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT93</accession>
    <name>W3VT93_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT93"/>
    <dbReference type="HOGENOM" id="CLU_074407_1_4_1"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000005">
        <property type="entry name" value="Probable 50S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="289" mass="32385" checksum="E6FC74F159F2952C" modified="2014-03-19" version="1">MKGLAFRKLSRTSSHRNHLLRNLVSSLIQHERISTTVAKAKEAAREAEKIITLGKRGSVQAGYGTRGYLYSQQETLPKLQELAQRYANRPGGYTRIHLHGNRKGDHAPRAILELVDNPFDLRMQMTARTLAKEVYDHITKRGGGDILTGRQFDLATIEQDERFNHFTRKNITKVVQYGGMEAREKLVTMAQEHLLRLKATVAVEGPRRIDEDRLKVLGENKPRGRLLTKPMAGSRPLAGQVGEGQPAPLPGKQRNSVIRIGKGAFAKRLNYRKPVIPTSSSSRSRSARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTK4</accession>
    <name>W3VTK4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTK4"/>
    <dbReference type="HOGENOM" id="CLU_2158054_0_0_1"/>
    <dbReference type="OrthoDB" id="10271636at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="114" mass="13412" checksum="10D75BDB59DBB4C0" modified="2014-03-19" version="1">MPTTNPLIEFFTEHYNFDVAMGAIEDHYEHLVDDLNEAGPHSSIEFRTAIYENFFQRIFEALSILGRSIQFADAFPEDTSVEDQLRFYQNLCEHIHEYFELEGTFKDLVPAWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTN3</accession>
    <name>W3VTN3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00889</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTN3"/>
    <dbReference type="HOGENOM" id="CLU_002458_2_0_1"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833396" description="DUF221-domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="38"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="212"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="419"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="798"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="756"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="855"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="878" mass="97082" checksum="9DB5D0DD43C6770D" modified="2014-03-19" version="1">MPSFSLVSGPAQLVVAALLVGRAAAQQATNSNASTSTVVSAIVLNAVIFAILFSVFLIARPRFKRVYAPRTYLVVPEEQIEPLPQSLLGWLPVWLKTPTTTILEKNGLDAYMFVEYLEMMLWVFIPTFVLSWIVLMPTYGANTTGEDTGFNRFILSRVGTSSQQQKRLVAPLLVQYIFTFWLLWNIRSRMSKFIKLRQQFLVSPQHANSAQARTVLITGIPNELLSEKKLRAIYSQLPGGVAKIWLNRNLKELPDLFDEREKWCNKLEGAETSLIKTAYKLVKKGKAQDASGSLPETDVEINAEVADQYVPKKKRPTHRLGKLPCMGEKVDTIHWCREEIARLNKEIEKKRSEVAVDYKNYPAQSSAFILFNTQIAAHMAAKSQAHHEPYRMTNRYVEAHPDDVVWANMNMNPYERKIRTAIGWAITIGLIIFWAVPVAFVGIISNIKGLANDVPFLGWLNSIPNVVVGIIQGILPTVLLAVLNMLLPIFLRLLSRLSGVPTRSGIELDLQGRFAAFQIVQNFLFLTLISSNAGQIAKYVAQVASQPTTFPGLLANAIPKGSLFFLSFVALQGLSGGASLFAQLPGLVVYYVKKFLLASTPRKVWHIDHDTSGVAWGTLFPSMTLITVIGTGYVVIAPIINGFVAFTFLLFFFGYKYLFLYVYDTKPPSETSGLFFGKAIRHIFAGLYVEMVMLTAIFFLAQSGPEGNKTQSAIPEGAFMVVLIVIVVGFHYFLNDSFRELETALPLSLTVGESQAAAGNSRTSNETALNEKRAPNGQGKFSMEATPASQGTGYDNGVPNGEKKQEALSDEHDSAFYHPSLTGEQKPIWLPNDKFGIGRAGVASARKAGLDATYEHTSVTEKGQVETDAYEPPGEPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTQ1</accession>
    <name>W3VTQ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTQ1"/>
    <dbReference type="HOGENOM" id="CLU_000022_45_2_1"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="94"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="668" mass="73670" checksum="9D21E283DE601A2B" modified="2014-03-19" version="1">MPKLASVEIDTPANKGETKIRRSYRAPDKLLERPAEGINTMADVFLHARDRFPNRPIMGWRDVVRMHDEQKEVTKKVEGKEVKETKTWQYYELSNYKYLTYNEFEERIQHASSGLVNLGLSKDTRFNIYAATAINWQNMAHACFRQSIPFCTAYETLGEEGLQHSLSEPDVVGVFTNAELLPTLANVIEDAPTVKYVIYDGKPGDKELNKVRDVLTGREGKLLTIEELWQEGKANPAEGHLPTRDDVACIMYTSGSTGAPKGVVLTHGNLVASIAAVELHVGDLLKPDDTFLAYLPLAHILEFIVECTMIYVGVTMGYGKVKTLTQASVRHCDGDIKAFKPSIMIGVPAVWELIRKGILSKVNAGGAIKKNLFNGALTIKKNKVPLLTSVVDSVVFKAVKDQTGGRLRIALSGGAALSKETQEFLNNALVLLLQGYGLTESCGMTAILTPEFYSYGPSGGTVPAIEVKLRDVPDAGYFSTNNPPQGEVLIRGPAVTKGYFKRDDVNKESFEDGWFLTGDVGQWNSNGTLSIIDRKKNLVKLSGGEYIAIERLESVYKASNLVSNICVHANSDAKQPMAIIFPREDNLVQAAQRAGVSGELEELCANRQVAKLVMDDVNGVGKKAGFKNLEMLQTVLLVPEELAMTAAQKLSRKDIIKKYEDQIKKVYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU12</accession>
    <name>W3VU12_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mfs transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU12"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS65123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="522" mass="57473" checksum="9A40FD2E5D772F34" modified="2014-03-19" version="1">MDKLTDLVLKPANGGKGNAVMTRTASKISDSLSDEKVGLPGIPALESDQTFYQRGMPDSLKSMSSDEIKFLEKQLVRKLDLHIMPVVIVMFLLNIIDRNGLTNAKLGTLTKDLGLDSHEYQTALMLLYVGYLLFQVPSNMLLPYTRPSLYLPGCMALWGIVSACTGATHNYGGLVACRITLGFLEAPFLGGVVYLFSCFYKKSELVARIAILYCGNSLSNGFGGLFAAGILQNLNGAHGLSAWRYIFIIEGAATVGVAFMAAALLPDWPSNTRWLQGNMKDLAIYRISAENGGAAEDEKPKKWTTGVTLAFKDPIVWLCVLMQHMLLVAQSYTYFFPTIVKTLGYNRTNTLLLTAPPYFFAFIVSVFNAWHAGATNERFWHITIPMCCSIVGNVLVVAVLKTGPRYFGMFLQALGPYAAFSLILGWISSSIARPKHKRAVALALSNSIANGSHLYTSYIYPDKDKPRFLKGGIIIMAASFLCIACAFSLKFILKRRNAEYDKAENEGKENANPVGFGFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU54</accession>
    <name>W3VU54_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Retrograde transport protein Dsl1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU54"/>
    <dbReference type="HOGENOM" id="CLU_274650_0_0_1"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="2">
        <location>
            <begin position="898"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1223" mass="129880" checksum="03B4CD99EEC63BDB" modified="2014-03-19" version="1">MSSGPASQDSSLSAATFLASISADSTVAFEPGTSSSAPGSAPALPISAKVSLIDAQIDALEGQAEKEVIAHAEELRARATSTRAVDHDLNRLWLSINQTSSRLVTVGPQVAPKAIEYHDALAQSSKQALLLSVLSDLLAATRLLERLEKLQTQSDPTALRSELPKVAQVMEPFRSRPALKSMPAIVELEKRFERLHTPSAETTAAPTRASHATPQSPQSPPTDLAVATGSPLNAKDVPKSEQVLSPALKVLEAARALIVAAGPDAGWKEVQIDLDAPALPPGAQATTQLPAQPTVQPAAGSQRSSSEVHRGLQYREDLTQEATPLTRNSSSSSSAAAAGARSRHKPKLGARLIRPQDQLGSGPFNAEDAALEEDGWGLDDDDNEELESAPALDESVHSAEQPASNQSVSQYVHQSVAALARDDHHSSPSSSVGMQASMSSSSSQRSAFAIQEPETRAAVPGADVDAWGLGEDEGADGHDHHDEAQAWDLDDDDDDVDADVKHSEAAAAAISDPPKVPATLVDSSPQDAVAQGVATTHQTNAQTPSDTILVAPLTDRKGHSDLAPPDTPATDAWGLEDDTDVEDGETAAAPSAVLTEVSFKDAEVESVAVADPAKSSASPHRDNAVVESSYESLSHQEAAPREPSKADAPSVTTAPDAWGLEDDDDAENDDPWEAEEQPQLVGNDRRKSPLQAPVQVTSRPSDSLALPNAQTSAPSAASEPAEPQNPPAQASAKAAEPAAQEPEPDAWGFEEGSSASEADQVERITAISPVKETTSERNADAKPPSEIKQTTPHVNDGDVGRVSPVEESFAAPSETPEEAARSPSPSPWGADFSDAESTGLPEPQASETPGTATVLRSTGPGVDRTDSGRRELDVQSVTESTTVVFGQQAAQKEPIKKEACVISKRSQDLVNLAESTMDTVIGLLRGSDSNGGNVDDAEALAGTIYKIFELHRALMPVAHGEVLRDVPALAMQFFNDSEYLARELARLVEEKGQAISAAWAQRDAEGAKRWSTKELVKLEQEAALTRALGQRWFEAQMTTQTKILLDTIVEADGFARTFDEHRFARCERCIKQVVQTLQQLAKAWRAVLVASRYHAAMGRLVDLVFQKVLHDVLDLEDIGESESEKIASLVKTLGSLESVFAAEGEQQSSAPLWVPSWFKTSYLIEILTGSLVDIEFLAFEAGALVDYSRKELAGLVKALFADTPKRSRLLQKIETASADVLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUA7</accession>
    <name>W3VUA7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUA7"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001515">
        <property type="entry name" value="Chromosome 12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="284" mass="29253" checksum="B0D13FC8A001B6CC" modified="2014-03-19" version="1">MTSATGANLNTARTALITGSSDPHAIGFTAARLLAQQHSFNVILSGRRAQAVQEAVVKLKEELASSSSTARVCGLVLDVDDQSSIDAAVLQLLHPSGPLLGGALDVVINNAGVGAPPGRGGKGTNTMFLQTELTTSADMIKVLTTNVAAPVAVTNALLPLLSRSDRPRVVNVSSARGSLAFGSGLEAERTGAMVYNASKAALNMVTLMQAKNLPKHTGANLKVNAASPGHVKTAFNNFTGLRSLEEGAAVYVHLSTLPDDGPTGQLIGNHAPFSTDASFVPIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUE6</accession>
    <name>W3VUE6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TFIIB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUE6"/>
    <dbReference type="HOGENOM" id="CLU_393360_0_0_1"/>
    <dbReference type="OrthoDB" id="2546157at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="701" mass="78398" checksum="526D316F71433835" modified="2014-03-19" version="1">MPSTCPECGSQETLSFIAEVGQDVCSDCGTVLQDLHLYEPTNRYEIAYALGGPSVERTAWNSLEPHRNPLVLQRWLSTTEEGRIRNRYHRKPEVDARISGILTALGHPTLLDQADFLFQRAREISWNIKDKPQVALPDNVEAADESEVAEGADTGYQDLPARFVPPPISWGSMSLYLATACCYAVLRLQGIRVDLETVADAAQIPFAHVRRAFHWLRLLVRDAVRGVRLFDPDVYVRRVLAFFRCQLESAHPTLNPAVLSYLKPLQASALGDRTHEISFDPTRILSNTPFEAVEATALHVCSFWWRQRQEGASKTRYAAFAAAVLAMEAHLKMPAPLTEIFRHTLQALNFDVAQAHRSDAEASSDNLGKRHAMALHAEICAALRLEALKIPWLSGLAPISQKVRYKNRRKAANKEEASEDGEPAPARMTELVRRDLIVHAIDVLQVWQAVQGKVTAKLPTATGATTDTRVSPRANVTSRKSRSKDKAPASDEASELDSDWDELECFVSTTRHADERDATEALKAEEADDDVEIWPRIEKRLKAEGIDTAANRMHGDSADVADAKPHPIDLLTDEQVDRLLFEHDELQSILRTDPAERAAVERAKVTLGVWTQESEYQRNAEIAALARRAEEEREAQHQRHSAMKRGSLDSTVAERAGPKRRKQPSSSRQDGQTKQKSKKGRTRAPAAVSLRDQRDESDWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUG0</accession>
    <name>W3VUG0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog</fullName>
            <ecNumber evidence="11">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00298</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUG0"/>
    <dbReference type="HOGENOM" id="CLU_004109_4_0_1"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000002">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000092">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000091">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="914"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="1006"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS65228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1138" mass="122927" checksum="C493210D5A62A71C" modified="2014-03-19" version="1">MNPSISIPDRLPVLPLPYPLVLHPNLLLSINISYAHSLSLLKAALQYSTLKDDVESSNDASPRSRQQGRSRLDSNKPIIIACVPTLRAPTGTASSDKPASRATNPALPADSAARNLTSAEDNDVRIRINDLYDWGCAARLMRLVRNPQNQTCTLLVSGLTRVRIDRWLSIRAPLTATTIDPKSNLAIPDVPIPLATATAFVDDESWPTFPEASPGDIDLVVRLKKASAELIDAIAQLNPPSDGNANTPSPIVGPALPLLPASLLKKLRGFMQDCRESQAALLADIVVGTLGGACEWSERVAILGDWDQRERVRHSVDVILNGVKRVKLARELIVALSSPLNPSNKETVIRSQLEALLTQLAALNQGVAARISAITSNSANRDDNKLGGGVIIRAPNSRNNTNNDNGSMPIITGPLGGRRGAKPGIKGVPGGGGLPGSGGGDDDEDELAELAKKLDQARLSPEARKACDKELKRLARIPQQSVERGVVITYLEIMAELPWEKISADLEPVRDPNDKAVVLHHKSANASAAAPAVEEEEGIVDRARRILDADHYGLEKVKKRLIEYLAVLELKTTQARERFEAEEDAERKAVAERRKATPSASTDEAAADGADDDDLSALAGAEEGEDLVAREQGISKEQIDDEKRRRRNEKLRVGDKGPILLLVGPPGTGKTSIAKSLASALQRPFTRLSLGGVRDEAEIRGHRRTYVGAMPGSIVSSLRKVGVSDPVILLDEVDKLGSGNGLHGDPMAAMLEVLDPEQNHTFSDHYVNVPIDLSRVLFIATANSLDTISPPLLDRTEVIHISGYTHDEKTAIARQYLLPKQIKAQGLEPDQLVVSDDVLLKVAMGYTREAGVRTLEREIGALARAKAVEYSQSKKGTLRDDNGQPKQYDPVIRESDLEKYLGPDTYEPEVAEANARPGVSTGLAYQGSGSGGILHIESLLLPPGSGYLKLTGSLGDVIRESAELALSWVKGNAFQLGIVHTRDSEFPKNDIHLHLPSGAIPKDGPSAGVAMTCALVSLLTKTPISPYLAMTGEVTLRGVVMPVGGIREKLTAASRAGIRKVLLPHRNRKDVESDLPKKVRDELEIKYVKTVWEAMEAAFGNKLFENAALALEANGYGHEHEGIREGRRLMHEIEDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUR7</accession>
    <name>W3VUR7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid droplet-associated perilipin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUR7"/>
    <dbReference type="HOGENOM" id="CLU_044381_0_0_1"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF49">
        <property type="entry name" value="LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="52198" checksum="9FE5088C1D522D4A" modified="2014-03-19" version="1">MAISVHRRCICQPFAPAADGASLTWAQVPPSACPKVRPDAFKGFRPPLRSNPSGHFQRVCPKSSGTAAELATVGIVVQELLDPQRVASPPPPYRLLGSISISTTLQPHPAATAPCCLKQLHTSHRQIPYQDPISAPTSRPALRSLSPVSFPSVISHHHTNLTLLIPTHSSLNLDMSAATAPAPNGITSSPSKAAFDQSAALKKIVSVPLVSDSLSFAQSTIQAHPLLATTYGYGENLVNSSLKAAQPITNRIHPQLAYVDSLALKSLDFAESKWAAPFHTNTQELFDAAKVPADHARGFVQAYTAALQKAYGERVYTPAKSAYESHIVPAYDSAHTKFDEIKSQNAYLQRATDIVKDLQANLAKTLESVSSRSKQEGDQATQKAQGISNAIFAELERVRHFAQSLPAESRKRVGPVMDTFTETYERLSKEARNPDVPASTRFLNVVKFVREQSLPALQKAIINPPSSTAQKAESVVDSAVDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUU6</accession>
    <name>W3VUU6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUU6"/>
    <dbReference type="HOGENOM" id="CLU_004620_3_2_1"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000097">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="83"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="594"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="899"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1078" mass="117448" checksum="C26B064DAE0353F0" modified="2014-03-19" version="1">MIATSLLARSRIPAVAAARSVRRFPVASTVASAVASGSRLAPIAWASSRRNLATLSSTENAPELGSRQVADSIFAPLDTFEPRHVGPRDRDAAKMLQALGYNHMDQLVNDTVSPSVRLEQSDAFYDQIKPLSESELAQRAETIASMNRPFKSLIGMGYQNTLVPPVILRNVLENPAWYTSYTPYQPEISQGRLESLINFQTMVKSLTGLDLANASLLDEGTAAAEAMILAYGQTKSKRKTFLVDRGVLPQTLAVLRQRAKGFGINVVATDLRTPDGHRLPPADQIPRDDIIGALVQYPDVDGRLTDWEALASEIKSFGGMSFGGMVIAATDLLALTMIRPPGEWGADIALGNAARFGVPPGFGGPHAAFFAVRDSIKRKIPGRLVGLSKDTRGGPAYRLALQTREQHIRREKATSNICTAQALLANMSAMYAVYHGPDGLRKIAAKVHALTRLLKHELTELGLRVVNRDGAFFDTLTIDLAKAGVGAVRVHEEAKKARINLRRISDTRVGITLDETVSIEELTDLLNVFAYATKNTRTGEVPYKPQDLLAIAQRIGLDASSTQSLTISSPVATATPAKDAAPVPDFSRKSKFLQQPVFSAHRSETQMLRYIHSLQAKDLSLVHAMIPLGSCTMKLNSTSSMMLISKPEFSQLHPFAPEDQAQGYDVLIRELERDLCTITGFPAVSLQPNSGAQGEFAGLSVIRAYHESKGEGKRDVCLIPTSAHGTNPASAIMAGMRVVPVKTKQDGAIDLDDLRAKAEQHKHELAATMITEPATTGCYFKDIQEAFQIVHDNGGQVYLDGANLQAQVALTNPAIMGADVTHLNLHKTFSIPHGGGGPGVGPICVAEHLAPFLPGHPLASTGGEMAIDPISAAPWGSASILTIAWAYIKMLGWSGLKKSTETSLLAANYVAHRLKDHYKLKYTGDRGRVAHELLIDVAEFEDVGLKVMDFAKRLIDYGFHPPTCSWPISTGLLIEITESESLQEIDRLVEAFISIRQEVDEIRAGKMPRDNNLLKNAPHTMHDVADAEWDRPYSRERAVYPVPELRKTKFWPPVNRIDDAYGDRMLVCECGGVEDYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWI9</accession>
    <name>W3VWI9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab small monomeric gtpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWI9"/>
    <dbReference type="HOGENOM" id="CLU_041217_10_6_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="205" mass="23153" checksum="F213BE184D2802C0" modified="2014-03-19" version="1">MASRKKVLLKVIILGDSGVGKTSLMNQYVNKRFSSAYKATIGADFLTREVMVDDRLVTMQLWDTAGQERFQSLGVAFYRGADCCCLCYDVNNAKSFETLDSWRDEFLIQAAPHDPENFPFVVLGNKIDVEESKRMVSQKRAMTWCQSKGNIPYFETSAKEAINVEQAFQTIARAALQQEAEAELYADYPDPIRIDQDNQQSGCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX12</accession>
    <name>W3VX12_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX12"/>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="8">
        <location>
            <begin position="144"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="434" mass="47805" checksum="4F7E3D2B23EE14C7" modified="2014-03-19" version="1">MGRNGVLGQLRGIDAFSKTMDDVRIRTNAGALITMVSALLIVVLTIGEFVDYRTVHLKPSLEVDRSRGEKLTVNMDITFPRVPCYLLSLDVMDISGEHVNDIQHDIERTRVTHDGKPITQGKKNLKGDAARIAATKGKDYCGDCYGGQPPASGCCNTCDEVREAYVRKGWSFADPDHVDQCVAEGWSDKIKEQNKEGCRISGKLHVNKVVGSFHLSPGKAFQRNSVHIHDLVPYLSGTGAEHHDFGHIIHDFSFGSEQQYHGLTTAKEREVKQKLGVKDPLEGVRAQTQQSQFMFQYFLKVVSTEFRPLSGDTLKTHQYSVTTYERDLSPGANAAAMAGMSNEGSGAHISHGFAGVPGVFFNYEISPLKTIHSEHRQSLSHFLTSTCAIVGGILTVAGIVDSLVYNSRRRLRRNAPNDHTQEGLGFTSKTGKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX24</accession>
    <name>W3VX24_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Macrophage erythroblast attacher</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX24"/>
    <dbReference type="HOGENOM" id="CLU_027445_2_0_1"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16659">
        <property type="entry name" value="RING-Ubox_Emp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="8">
        <location>
            <begin position="210"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="369"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="369"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="49842" checksum="E29ECE9E58888919" modified="2014-03-19" version="1">MAEAVTVDTSPERAATSSSTALNLDGILLLEAPFAKVPFDELRRQQKTQQRLIERELQYATTTFSDATKPGGSRAGEVDKSLDLVLGRLKGLKRKLAPLAEQAKSSLRMAQSRTDHLANLHTMADAESVEFGEWARTRLDRMIVDYMLRRGYREAAHAHAAQKGIQDLVDVQLFDEIARIEDSLCPPDWHRATQHATHEVPTGVTRPSCGAALAWCSENKATLRKIRTPLEFNLRMQEFIELARVRTSDSIRDAIAYARRHLLPLVTATKPSTAASEEAEYERLAAEAIRKEVSRALGLLACAPGSWAYADLYSVGRWAMLRDSFRACALQIHSLPAQPILHIALSAGLSSLKLPQCCPAVGDGGNVDCPVCDAKGLGVLARQVPWSHHQNSTLVCSVSGNIMDDNDPPLALPNGRVYAQSTVVDLVHKGDGCTIVCPRTGARCSLHDVRKLFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDI6</accession>
    <name>W3VDI6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDI6"/>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="60102" checksum="8F89B83DC5C592E7" modified="2014-03-19" version="1">MPASVSSKSSGEVKTSKVPVETANENGARVSHQPAELIVDDDDAMLASRMGHKSEFAREFKSFSTISYAFAIMGLVSSVATTFNSPFTLGGPASTVWTWFIGSCFNMTLGLSIAELVSAYPSAGGLYSASGLLVPRNQRAFVAWLTGWLNFTGQIAGIAGTEYGLSQMIFAWAYVITNGRYVATTGATVGLYVALLALHGVINCFGIKTLARLTSSYVIVNLGITFIIIIVVLAKTPLSEMHSAAYTFTEINNQSGWSSNGLAFFFGLYCVQFVMTDYDATAHISEEVSRAAIAAPVAIVVAVAGTGAVGWVLNIVMVLVSGDVASQDIATWPGGLAFAQILYQRAGKVGFLIIWPFVCSVAFFVVTTALQANARSFYAFSRDNALPDRGFFARVNKRTGTTVNAVWLVVIPCMALGCLALASYTAVTAIFALAALGMDSSYLVPIVARWIYWDHPDVQYKPGPFSLGRGVLGKTVNGIAIMWTIFECTILAIPTVKPITQFNFNYSWVIMAGVLLIATIWFVAFAHKHYQGPRSTLTPEQQEKLGVISRDEEGIIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDY9</accession>
    <name>W3VDY9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1742-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDY9"/>
    <dbReference type="HOGENOM" id="CLU_088285_0_0_1"/>
    <dbReference type="OrthoDB" id="2158714at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24033" checksum="486C844409F9F348" modified="2014-03-19" version="1">MAATGGKPANVYLHRQAGTPKSCFVCYKQTTHVLVSQSLPTQDFMYVCHAHLADRHFATKLSDPSGTSTTATAAATTAAASGDRLPDKVSQQEIDKIKQEYEAKLKQKKDKDDKDKDKDKSGESKPFSAMSVAGSVFSTVTSTVSGLASSAMASIPNEAAPLAASTPTVTATDQLSKQHPLHATYALHREFYAARVRNYNERMFKTKERQLNMPPAPKNALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEN7</accession>
    <name>W3VEN7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malate synthase</fullName>
            <ecNumber evidence="8">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEN7"/>
    <dbReference type="HOGENOM" id="CLU_018928_2_0_1"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 8" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601465-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="799" mass="88506" checksum="036A4455FAC99F1D" modified="2014-03-19" version="1">MVVKAIESYEQFKSLIEGDKPIIIDFWATWCGPCRVIGPIFEKISDTPAGDKIDFYKVDVDAQEKISAEVGIQAMPTFVIFHKGQPVKKIVGANPNALQDATRTAVLVAELPELASRPAKGDPHLDGHLTSASTSVAQVRRGSQKRHATGSNGLDGLALERLRRLGLHKPPPALASAATAHRKVLPRPRLPMTQRACSSGQVEPRPMLIESKAPSRRLEYIDFCVDRPRVRLIFPPTIPASSFPAPPLSILLISKDLHPIATTKTSSIMSVEGVRVLGKIEGDQASILTPEALRFLAVLHRSFDSTRQSLLKARQLRQARFDGGALPDFLPETAHIRNNPTWQCAPPAPGLRDRRVEITGPVDRKMVINALNSGAYTYMADFEDSTSPTWANLMDGQVNMRAAINRSIDFKVNNKEYKLKPQGQTAVLLVRPRGWHLNEEHIVVDGKPMSGSLVDFGLYFFHNAHELVRSGYGPYFYLPKMESHLEARLWNDVFNLSQDYIKMPRGTIRGTVLIETITAAFEMDEILYELRQHSSGLNCGRWDYIFSFIKRQRYNAGSILPDRAAVTMTVPFMQAYVNLLIQTCHKRGVAAIGGMAAQIPIKDNPQANDAAMEKVRADKLREVQAGHDGTWVAHPALVKIALEIFDKNMLGPNQYHVRREEVKVSALDLLNSNVPGQITEAGVRANVAALLVYCANWLNGLGCVPVANMMEDAATGEISRLGLWSWVYHKQKTAEGNAITPAYIDRILDEEAAKVSKIGASVEKAKRYIADQVRAPAPDEFLTTALYSHLPHQHAPARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEQ2</accession>
    <name>W3VEQ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEQ2"/>
    <dbReference type="HOGENOM" id="CLU_017718_7_1_1"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="33"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="323" mass="37025" checksum="404B2FF10A4ED8CF" modified="2014-03-19" version="1">MTAVSNAQDHTPLQSYVGFDSITKQIESKLLKRGFQFNVMVVGQTGLGKSTLINTLFAAHLIDTKGRFAADEVVRQTTEIHPVSHVIVENGVKLRLNIVDTPGYGDQVNNENCWDPIVKYIKDQHSAYLRKELTAMRDRYIVDTRIHCCLFFINPTGHGLRPIDVTVMKKLSDVVNVVPVIAKSDSLTMDERDLFKERIRAEMQYNNIRIYPFDNEEYEVEEQELNDRIRNLIPFAIVGSESTVVVDGKQVRGRKNRYGVVNVENESHCEFVHLRNFLTRTHLQDLIETTAQIHYEAFRSKQLLALKESSSKQQQAQQQPAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VES6</accession>
    <name>W3VES6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VES6"/>
    <dbReference type="HOGENOM" id="CLU_456496_0_0_1"/>
    <dbReference type="OrthoDB" id="2524554at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="552" mass="58181" checksum="0D413D014DD8A296" modified="2014-03-19" version="1">MKPVLARVAAASRASRASRVSCASTSAAPRAVHLTRTAHILDLAKTAPAGPSFRRGYSTAPNQQQVLQSFGTPFAQFVYTLSRIARIITFSAVGVATIGLVSFEAAHQYVEHIAMPAEAASAPSNDEYGWNELALEESWSGSPAHRGTDPRLGIKGRHAVRSAWMCVNWGGGIAPGVLFGGGAAGNAGLGRTAITSMASAKQLRVDDGMLLAMQYLNVAVKIAASKGIKLPETDAIRAGLVQPGQTLGNVDPLALALEAKLAAVKERQGSKGAMESAIGNYEKLYDIASLADHGDRSSRLVRLATKLGDLHSALGRNDDAQQWLQRAIAIAAAAGAHTPNSPTTAAPEAKDKPRSGLRGWFGSAPTSDPSTEAQPEPVSASVGVVATPVLTRSLITALVASSAHYARSASGASLQSALQTQMSALQLSTAELERLASTPATRDAELHALWITHHQSILELHVAETMYAISKSGSLPRFLPFGKMDDKRQPIQWLVQADERATGVVAALSQGGELASRWKGERQVEAAAARVLRDAKRVKETANRSRTTLEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VET3</accession>
    <name>W3VET3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VET3"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="28"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="554" mass="60857" checksum="D9B9AB869DE38438" modified="2014-03-19" version="1">MSASSSAPAAAPHAVSERRLLWKIDLLLMPLMTIAYGLQFYDKAILASASIFGILKDLELSVVHPGTPPKTSLQRYSTATSAFYWGYLVAALPMALLVQRFRPNVFLGCAILLWGLIVILTPAITSWRGLIAQRFFLGAIESSVSPGFIHITRSWYKRSEQPLRLGIWYSATGLFSIFSGLVNYGLGKAGTRPGAKLHAWKYMFLFAGSLTILFGLLMLLLLPSSPLGDALLSIPGYNRFSPEQKSLAAGRLRSNITGEAELDDDATLRTSHAEENKHDEKDDSAPDTPAEQVVLNDRLAALNVSASSSGVRQRWNGAQIKEALMDYKIYIFFLQAIAIYICNGGVTAFGAYIIKSFGYTSLRSIILQTPGGATTAVSIYVSTLVVLKVRNSRSVLLMLTCLPVIAGAAMIWKGDWSNRAIPLAGYYLLPIFGAPFVLMLSLSTANVAGATKQSVTSAFVFAGYNVGNIVAPYLTIASEAPKHYRTTFVAIITCMAITIGLTVLLDVGLWWQNRARKLAREREAKSKQEVDEIKKRAILEDWTDWQNPYFEYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF44</accession>
    <name>W3VF44_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF44"/>
    <dbReference type="HOGENOM" id="CLU_341051_0_0_1"/>
    <dbReference type="OrthoDB" id="2549435at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="815" mass="91791" checksum="F907523B28418AE0" modified="2014-03-19" version="1">MAFRRWHSSLPSLGRLGAAEVQPSGSRLAPRPSVGSNLALSAGVPDFLAPALTQGPTRQHRPYASTSAARPFSIEYTAPQTVPITTRSPQLLDVARLVPDQTDFSSFFDTEASTIGLASAMAPLEAARDEQEVIRAADQIYKHPLLVQERRRAKRLHKKGTPPDETWSCKLPCNEHFVLSLFSTAFSITKASGKGDVQAMSWTITRTLQAIAQAAHATSLSPAFLCELAGHARAEAARTTLKLLLTMIDDRLASAPAPNAQLSLSDRDHLSRTLRRLMMAFSELGDFDRTQKCFELLQKHALDTDIRTFQSEFIALCQKVRARSDHADPKCIANNLEYLQQQLLLLKRQMDERDIAMDDTFLATIVHSFSAPLRTHSAASMSRDQVAAMLQVVRAIAARSMDSAAESATSPRLFGAIVQAEIDAMAHLRTQGRSRLQPPRRISTLMHELRTRKRPRTRRMVGMHDRKHVDEWQLTELFLRLRLAAALGDMSTGKELLRELLAIKSLQPSTPSARDLLIKQRSSVVALFSAAMRRRPFTSDGDEALAVLRIGFGCSSTDFHEVWTGVQRPANFKPKSSDDAWQPSITVLRLWRRWMGAWREDSIAHSQRTDPGTLSHVSDDASEHMAVGGTYAFKNPWRTMKDALTILDINLTHYEQRDSQQDRRARRRFAWLFRDKVVLDSVVRVCLTGGRRRNGVGMDRFVDRRLDVLIRTLARVDAPARVWERLEASMLHHLSRIDPTVMPTERVVLQFDQIKALKRKALLRNTDLLKAYRDQQHQPQHPLETGSVTVLRHMLNQQHQQPHPNPQPAIQPCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFH1</accession>
    <name>W3VFH1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFH1"/>
    <dbReference type="HOGENOM" id="CLU_315700_0_0_1"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF5">
        <property type="entry name" value="FERULOYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833115" description="Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="6">
        <location>
            <begin position="159"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="925" mass="99909" checksum="FDC5ED5A0BA8B350" modified="2014-03-19" version="1">MRSFFWQVLTAGLLATPISLATCQAPPPGGVDSLASGNHWAPPPHAQPGIPPSPQGQPGIPPSPQGQPGIPPSPNAQPGIPPAAGQGNPPVGSAFNPRDGWGGFQPESGFSGTPTKALMYTYVPKSFKKGNPVVVGVHHCAGTGPGYFREYPDWPKAAEEKGFMMIFPSSPGETGACWDVSSAASLKHKGGGDSQTIVNMVKYAQTKYGASDKKVFVVGHSSGAMMTEVLAAAYPDVFVAGAEYSGVPAGCFKTNKQAGADWNSACAGGNVRESPEYWGQQAKDMYPEYKGSYPRMMLVHGKADQTINYENQVEAVKQWTYLHHLDANKPTKQYDDAQKPNYHVSEYGHDVLAISADGVTHDNPARVDLTVQFFEEYRSSTHPDVSVEGGLLTHRVVSVEPLQHRSRLLGSLRSARSAALPALRRLISPFRDSVGDHSALPWAEPAVEAAQALSRRSAKLHHRPARFTEALTSRNASTSVAVTYRAVPRQFLPEVAKLRTKYFVLHDDPRHRPLHPVEVRARTYKAASIQPSIHPFSALLLSALLAAATVKAAPLKRATTCKVDSGHYGSITINGAALSLGNDGKFVVGGQPQQFRAGICQTHNEDPKGYTIDTIGYIVNAYDESQCLTASALDQTGATFSFQDCKLDANHADATQNFAWTQDYVANFAKLYFNGESNSYVNDTSHSAYNLRGEGGANTDLIVGYSLNKPQTIPETHFNLNYIPSSVALPPPIKCSSQKVGQILFNNQTAASNTYSGPINAKWEAQAGTTDKFVFEQCDYSSAGFTSNADVTYGRLRPGTDLSNGEYNCYQYTGDDGATGSDNTPSASPWINGLQVQECWNSADNAPGEQLVRLNNNDNSFAFVPFPADQPQPGNEYWYTQGDYVDEYGVTQYVWDSAGIGQVYLDSSNANLTKYPPGKVTFQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFI9</accession>
    <name>W3VFI9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFI9"/>
    <dbReference type="HOGENOM" id="CLU_622831_0_0_1"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="54937" checksum="B3135A547F70F54E" modified="2014-03-19" version="1">MPRRKIGADLKEALCKLYEAGDISADTIEKHGIMSRATFFRNLKMYKSGASLEQRHSTGRKTNADKLKEQDKLELDALRPPHLSHLELVLLLDEDDKGLQEGSARNKRKAKANATSSKRRDLGKSAAGEASRSEGTAMRDESGSESDGDSDDAAILAKHQALAKLRQAARSFLAADGVASSSRGVDQSTMDDRSGINDLDSLLKPEDSHYSHVNRGALFIVRPKGEAREDGPTGGIIAAIALRSLIWTPEIYQALGPSYAGRSIDRICNLVHLRVDARWQRRGIGRWLVNVAGLKAAKLGFSHLYTQSDSGRGELLSFWQRTGFTEFARFDNVARFEQVAAAATMPANAQSEPTKPARRATHATLASSSTAPPRRTIAYANDHAAAGQSSPQIQTPGQTGPDGAQVNQLTAELDLPIPLDPSISSNYVDQSLLVRAERAEPIVSSAPHAAPASAAASAGDPTDTASQPVNMASTATAAGSAMPSNEPPRAAVGPPPRRIAFHEAADVEGGKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG25</accession>
    <name>W3VG25_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG25"/>
    <dbReference type="HOGENOM" id="CLU_072390_0_0_1"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="86"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="229" mass="25253" checksum="BD256088D108C342" modified="2014-03-19" version="1">MSSSHPQASGSTPSSSEAVRVYRAPSSSSPSLPPPADDDLKPTPEELKAAFKSTLLGRHGPDAPLLTRALREKEEQRLGLHSSRNRHWDDVKIRIRFSDRTMVEGSFSEADKIDKVYEFLESVLDPAAKGKGVVIYTAPPKCEYRRMDAKVNAKTLRQLGLIPSAVVSLRWDDPQMNSNAYPAPIRQDLRSQAQDLPSSNAQSSTAPAASAPEDKQKPLPKWLKNIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG61</accession>
    <name>W3VG61_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG61"/>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="109" mass="11543" checksum="895BD176C21BD545" modified="2014-03-19" version="1">MAPKAKKSSQDNINTKLQLVIKSGKVALGLKSALKNMRSGKAKLVLISANTPPLRKSEIEYYAMLSKTAVHHYQGTNVALGTAAGKLFRVGVMTILDAGDSDLLSTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG72</accession>
    <name>W3VG72_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG72"/>
    <dbReference type="HOGENOM" id="CLU_036007_0_1_1"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="556" mass="60694" checksum="76F70A3466505320" modified="2014-03-19" version="1">MPGTPKSTPKKAAASTPVGSPSTSTPGRMTRAQARASGVKVKTPSPLKSSSTPRTPKTPKTPKASKAQEAESPSKTNSPHKVSPKKSPSPAKASPGKVPASHAKLARKPTSALATAQPIIAEDSEDEEEDSDVEVQEEEDEEEESDLEDGQDVSEKGMQRLMAALGDDGLDEVDMAALDELAGDEDDEDDEDEEDEDEEDLEEEAEEDDEEDAAEEVDDDIPRVKPNANGDTLAASIARSGLVPVEESDSDSADEEEKEEEESEDEEEAIAYEDLPDDIELSEAAKASRVQRIKVNNEAALRRITSDISLDTATSKLPWIETMRIVYPSTISSSVTDVENDLERELAFYKQALHAAVEGRKLVESAGVAFSRPSDYFAEMVKTDEHMERIRQKLLDETAAIKASEAAKKQRELKKFGKKVQVEKLQERIRNKKQLNERIAGLKRKHGDVDDDEDQFDVRLEEAIGDKPKQPQQQRKGREASGKAKMPRTARDAKYGFGGKKKYSKSNTAESTNDFGSGPTRGARGSKPKISGKAGFRPKQKSGAAKRPGKARRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGD6</accession>
    <name>W3VGD6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_247675_0_0_1"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="824"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="935"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1359"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1479"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1409"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1493"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1522" mass="160472" checksum="CB9D30D2330AB23F" modified="2014-03-19" version="1">MPRPLALFRLSLGPGARHPHPHPPQHSCRALLAALRRIGALVFRPCCSNAIPISLCTPAALRVLCAGVVAASSGRESTPPSSPPPASPSASPSHPLRRAICVTLDLVPCEIQPPLRPEQHFSASQLAKTSSCIPLGADTAIPSLVHRAKSPVTTSSCARARRGRCSRHPPVAHRTTSYRTAPPTTLPRAAPIAPSPATHLSASHAAVSDRPHIPVRTERTASFVIARLGASQQSPTRFLTELQLCSSFDRPSVPQLRRPSQLCTGETSASFGPSSLKVLTTSPAGGSASVIRPLRGPLQFGEAIASPGTPAAVVRSELPLVTLRTNIHEPVPLDQPSKASLQLAPVVTHLAPGSYPGLPCRQHSANQLRMYHVDTVSAFDTACDAMQRSAHTRHEESAIHIALPERLKLNAAGLCGNAAPSDASGLLGCALAAVLAHFLASLYWAVGSTQSWPRYKAKSEALYLGLKLSIAGKHLRGIAFGLSPKDPRTLLFRRCCPFSLSSRAASYSSSPAVLMSYVVRLASHDHADLVARTMFDMDYAHRASSSPYRPGTADGSWEQAKQPGVGELRPDLYAQLPPSTTSSSQLRPEPLQTAAQPSMLGSQMGVYLGPNVVTPRQSAFPRDQMDASTQFASAGTMDAFGHGGPGAMSTDTPRATHFGVSSAHDASKMGMATPSHPFDTASGSTWQTMQPQAEMPYRGYAYPVQTSAGSWSAPGGMSMSQNAIYDTSSSSANTSPNRSQAYYDMSGEHHFDHGGYASHMGAAPAYPMYAASSSKFGGAGAYAAAAAQPEYQPEEIDSMLGQVSTLYKTANTKKMAEFYRDKWARMWLTCNYTLKPSIQISIPRTILHESYRRACDAFGLEPLQAASFGKVLRSQFPDVAQRRLGGRGKTRFHYCGFGTSNEREAIKVKSLLEDEKAGKLQLSAGLSAEYASEARAKARSEGQDSETSYRSQRSAEASPGEGHTNAGRALKHEHSPHASLDGSVLGTTGMGTDNRLIASAFATLNSAILTPPGTSSGAGYAGQDALRFSTQAQPLSQGQAEPAASSSTTGFMPRRHTVSHSYSGFSDLGFAPSAHASSEAGDAAGLPSSEVSSFGVGAVSGIAEPAQSGSLLNSPASSLHGYQYIQDPRHMPSSMPFRRSCQDLPDWPTVGGEAGSGSTYGTSTPAAASGGASAGNASLPAESRKAWREYESLCQALLYSIYLGPDPVSFEQRTTLFWTSLSAASREALHADAMLQGMVLRADGIIFRQLLNKLDGMIGDDVADERMPALRSLARMLAERMAELVRDALPEACATTKVQASQRMGESLERVVKIFEAVRTFREESMLDVGGDCDADAAQAWWAANAGAGSAGGPRGLGLAGVVRGSRPRSGTQSSLGSMAGPLANLQLRRRDTSVGSSLSDSQHAWTGSEQRASSSASESEVSSIQSADLGAMPNSLYAPLVRKPTSAGGLRARMASHPAPESSTHNTLALANSMASSQLAAAMPVSSPQHFATPSAPNSRPTTASTSAPPPPLDWGDQPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGD7</accession>
    <name>W3VGD7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05445</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGD7"/>
    <dbReference type="HOGENOM" id="CLU_017266_1_1_1"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="8">
        <location>
            <begin position="127"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="602" mass="65893" checksum="8CF505F83BB42B03" modified="2014-03-19" version="1">MAASLSRTSRSALCRLTRASNSACIGPGSAGTITRRTASSAARPTDDVDPYHTADASSSSASSSSNLAGRQRTYGQPLPHSHPHLFPRRGVLGSEDALLRPGDALPHDGLYDVGTGIVATEQLTPGIPKSEYEERRKKLMDRLPDNSVVVAMSGRVKSMSGNIFYKFRQETNFWYLTGFQEPDSAVILEKDASSARGYKMTMFVQKRDEHNETWNGPRTGLDGAVDVFGADEAYELDPAILLNHLKQILPRYTHVYVESPTQPTTPRRSASSAQSKAGNLLNYLSPPSTTALDVFAKKSDFEAVVKLLGDTRKCHSLAREVERLRFVKSRNELRIMKRAGRASGEAMSETMGFVRPGVSEAQLQAVFEYNCGLRGSQRPAYVPVVASGSNALTIHYVNNDRLVGPDQLVCIDAGGELDGYASDITRAFPSNADGRFSSAQRDLYSAVLQVLKSCTQLATEEQCFTLADLHRRSVDFLRQELRQIGFHTGGTLERVLYPHYIGHWLGIDLHDCASVERTTRLESGVVVTVEPGVYVPYDDAFPKHFQGIGIRVEDDIAVGETDNIVLSSAAPKEVVDVEAACARYLDQKHTHGTASFQPAMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH56</accession>
    <name>W3VH56_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH56"/>
    <dbReference type="HOGENOM" id="CLU_100273_0_0_1"/>
    <dbReference type="OrthoDB" id="2553844at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="243" mass="25640" checksum="585A9D20E6CCB368" modified="2014-03-19" version="1">MAATSAPSAAAELRTLRLDDILSDLDMLSSDDVLFTLARSSAPTTTRTHTGEDLLSSFERGSLDASTPQDRRKAYVALSHALVAGFAHASRLNTERASAAQVGLVLPSERTQSGSSRPTAAHPQSQDATRADLLHSKVATLQTQADAWHAALASAVGQQPESSEERRRQDAAIPSTREADIAHGSQADTGTSDDRMASELSDANTKATTEAEPAPAPEEAAPRLDATPAAPDFEDDDPWNDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHB9</accession>
    <name>W3VHB9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04991</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHB9"/>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001148">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="118"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="316"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="787" mass="87819" checksum="99A4D2E35F724EE0" modified="2014-03-19" version="1">MAAAQASTSADAARPSKRSKMDGTANSTPEASIANPYLAHMSEEELAASAAATNGSIADDHPLAGLIPRKVTGAQARKVMEGDVNPFSVIPKPYSNEYKKILAKRKELPVYAQMDDFYHLFNQNQIMVMIGETGSGKTTQIPQFVAYSDLPNTQKTKGPDGVLAPRMIACTQPRRVAAMSVAKRVAEEMDVSLGKEVGYTIRFEDATDRRTTFLKYMTDGMLLREAMHDHNLERYSCIILDEAHERTLATDILMGLLKEVVQRRSDLKLIVMSATLDALKFQKYFNDAPLLKVPGRTFPVETFYTPEPEPDYLEAAIRTVIMIHQAEDAGDILVFLTGEEEIEDACRKIKAEADDLAATNPDLCGPLKVVPLYSSLPPAQQQRIFDAAPAPLTPNGPPGRKVVVSTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVTPISKASAQQRAGRAGRTRPGKCFRLYTEKDWANELIEQSYPEILRSNLANTVLELKKLGISNLVTFDYMDPPAPETIMRALELLNYLAAFDDEGNLTPLGEIMADFPLDPQLAKMLIVSPEFKCSNEILTIAAMLSVPNVFVRPNSQKQQADAAQAEFAHPDGDHLTLLNVYHAYKTNCRDNKTAADWCWQNYLSHRALMQADNVRSQLQRLMERHNLDLVSTSFEDKRYYTNIQMAIACGFFMQVAHRAGGNKKAFQTIKDNQVVSPHPSSTLDHAAEFVIYHEFVLTTRNFIRTITEVKPEWLYDFAPAYFDPNNMDGEVKRIMATLKARKDKPAAPSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHC9</accession>
    <name>W3VHC9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Shr3 amino acid permease chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHC9"/>
    <dbReference type="HOGENOM" id="CLU_080510_2_0_1"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22581" checksum="AAD52C86041B4E83" modified="2014-03-19" version="1">MGLRTGLIIGTTSFLLGTLAMHWTADHLILWQAPVTYDSVVTAYTYYQDTMVDMPSVHRKLLLGIGTLAALLLISKALGGRESNWLFDGASLFLFGAAGLVYYHKIEPSLATLPPRAPSPGSGAVDARDAVFAPLREIATSHTVLAVALVGVILLQSGQYYSERLEERERIEEDEARIRRRQRRREQEEKRKERLQAAATQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHL3</accession>
    <name>W3VHL3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="4 12">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG13</name>
        <name evidence="14" type="ORF">PaG_05106</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="4 12"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHL3"/>
    <dbReference type="HOGENOM" id="CLU_934459_0_0_1"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="13">
        <location>
            <begin position="227"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="340" mass="36369" checksum="35319704BB3CDB70" modified="2014-03-19" version="1">MLCGPRGEFERLFFGRISRTRSHEQGRPPNPTLLATHDRVDELLTLAMTAADVSASAASAKASQLAVFVTVGTTRFDSLVRAVVSERFLRALARTFPPAPGQDSKHWIKLVVQYGTSPISDILTAMDAASVDAGSEIVPEPGLRIVNGRRVYQSGANIPGLDPGQTGTLPGMRIRTAANSMRQDDPRGTVDRMFDSIVQEAKAVAGTSSAATTASQQQSITVEAELDCGVELQLFAFAPDLKSYIESAEVVISHAGSGTILDTLRVRPHPPALVVVPNTSLMDNHQVELAEALGNDGFLTVGSEDSLVKDVARARQATHAPFPDFDPARFTSLVDQVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI21</accession>
    <name>W3VI21_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_05175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI21"/>
    <dbReference type="HOGENOM" id="CLU_040211_0_0_1"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS61214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="425" mass="45012" checksum="A4DEFCB2F6362015" modified="2014-03-19" version="1">MPSATTQAKSTVEIANAGFSHIQSSKSTAVRTSPDFLVLVLDINPLAWTRRSEALNKGKRKQVTADVALEDALSAIMILLNAHMAMQHENGLAIYAAAGTGIAQLLYSTASFSAKATEAGSESNAAASSSTHKPDANTYQHFKLVDDHLEQGVRDTCKAMFERAKQTQEFAEASADNDAAKHAALARSVNVGIVSALSQALCHLNRLGLSDASDAANVTGGIATTAQTRAGGGSSASGGANGGGGSGGFGSFKSRILILSVTQDASTQYIPMMNCIFAAQKKGITIDVCKLLGNDTVFLQQASYLTSGTYFRLSDEQAGPSGQEASAIDLRSALVQTLLTTYLPSRSMRSSMNLPTLEEIDFRAACFCHRKIVDVGYICSVCLSLFCQPRPFCLTCRSKFPSDTLARYQRELELTSNVQDATTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI61</accession>
    <name>W3VI61_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI61"/>
    <dbReference type="HOGENOM" id="CLU_023751_2_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="69291" checksum="BC5625D7E883892A" modified="2014-03-19" version="1">MQALARMRFRYRGAAAMLLGSAHELCAQLTGQPQAPHGHVALDPADEPRASSRTMSAPSKLCCRFSSNSSRGHLGPPCPKPSQKVAACSIRPSRPSRISKLRHRVHHSSSLRLALFHPSRLQPHNNAPDVPPPSLRGVHLQALIVSVPASFASAAGALDQHNTDTRTLVRLRPSVNDVEAPAAKMISSRSSSTMSAMSMVLFVFLTLAASACAQMAPVRSRPVRARDAFSDQDPLNKEGEDHGKPTVPSGASLVSLPITSDASVATYWTANPNNATATNAYIMMHGKLRDGANYWDVLDTVLNQAVNANHAGAVSTSIVTAPQFYSTRLNSGQYTNSQIAFADTNVWQAGEAANRPMGTNVTSFDALDALLAEFSDTAKYPSMKQITFVGHGGGAQLISRYAVVGAGLPSGSNIQLRYVVGDPSSNPYFTLDRPLQDTSVADKATCPLYNRWRYGFDRFNGTRAAPLMTPQQYFARFVTRDVRWVVGYQDTTNDGDDTCMAKLQGGEARRDRNLAWWRYLNTLAGTNQDLTGFPGSLPGMTSWANVTNSTLAHRLTVVYNADHNAQEVYTSIEGTSALFDDSNNVQLGWRPQGWRNVTTSTQTKSPAGGSTGAGANSSSAATISSYRAAAASMALAALVSIAVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIA3</accession>
    <name>W3VIA3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIA3"/>
    <dbReference type="HOGENOM" id="CLU_071479_4_1_1"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14855" checksum="C6BEEFCCB788332C" modified="2014-03-19" version="1">MAATSIPIVKKRTKAFKRHHSDRYHRVGESWRKPKGIDSAVRRRFRSTVRMPKIGYGSNKKTRHLMPNGYRRLVVSNVRDVELLLMHNGVYAAEIAHNVSSKKRIDILEKAKALGVKVTNANARVRAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIB3</accession>
    <name>W3VIB3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_05197</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 18">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIB3"/>
    <dbReference type="HOGENOM" id="CLU_004962_6_1_1"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="180"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="509"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS61235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="630" mass="71056" checksum="176F412C626E6EF4" modified="2014-03-19" version="1">MSNSGQAERQQRLVKAIGQITNKPAPPEIDFTIHTTDDGTQVSTQERVIKDVQAPAFQKPTDEQFFSQKDPSKPDIAFLKNHFYREGRLTDDQARFILTRATEILRQEPNLLEVDAPITVCGDIHGQYYDLMKLFEVGGNPADTRYLFLGDYVDRGYFSIECVLYLWALKIWYPDTLFLLRGNHECRHLTDYFTFKLECKHKYSEEIYDLCMESFCTLPLAAVMNKQFLCIHGGLSPELQTLDDLRSIDRFREPPTHGIMCDILWADPLEDFGSEKTNESFIHNHVRGCSYFFTYNAACQFLERNQLLSIIRAHEAQDAGYRMYRKTKTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILNVCSKEELEEEEEEDEIPITPTSTAEEETAERRTIIKNKILAVGRMSRVFALLREEAERVSELKSSQTSAKLPYGTLVLGSEGIKDAIANFDDARKVDIENERLPPDLIDADEAGPASPADGARVSSPAFEDITSPGSPASPATPSSPVAGAHRRGHSRTSSLGTTMSSPSNRRRSLESTVSMIREALEGTDTADDRQLEKLANDITSPVSPKGAADAAARQRSREVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIG9</accession>
    <name>W3VIG9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIG9"/>
    <dbReference type="HOGENOM" id="CLU_091090_0_0_1"/>
    <dbReference type="OrthoDB" id="5399848at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="271" mass="29278" checksum="6F1E9722B9560929" modified="2014-03-19" version="1">MGNTNSALNRDPPKVHRTLCGLRYDNAFGFASHEPRGITTTCFNDVVLEPLATWVLLLVMLPLLAVALKKRRSNAKLSSSTTSRLLHYRASARRGDGSFSGKHAKLRSVLDVVYMLLIVAALLMNILQIVRLALADRGVGLLPFNLAGILIVLVLMHVRTADGVAVSTVCLAFWSLLITFTSVALAGMGKLEGIEDRKGTEYLLSDEMIDVGVQVGLYAVFWVVEALRVLHRLTTARKQALGTARLHEQPGSEALGTTQSGEGKMIGSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIN5</accession>
    <name>W3VIN5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIN5"/>
    <dbReference type="HOGENOM" id="CLU_030515_2_1_1"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="189"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="372"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="534" mass="58173" checksum="9E06B8BC99064861" modified="2014-03-19" version="1">MAAPGGLWSAAAADEHETGHSALSRLLTPMATSTLTSFARAGEVVRLSHALSTTQIDKMKLHVWMVVAAMVSGGWARVVPLEQAPYARSAVAPALEPRAGSYANAVESALHNRIARHIRPDYSPLSKRQAAADNGAITNFGSSPPQPVRGSKGAPFLHGSNTDIDRQNVDYLSPPPTDAGTVPNLKWAFSLSKSKLLNGGWVREQVVTDLPASKEVAAAEQRLAPYAYRELHWHRVAEWGLVLNGTVRITANDEEDRNYVADANKGDLWSLPRGVPHTLQAGPEGAQYLLVFDDGDFDASGTTFAVDDWIAHTPRDVLAENFGWNISAFSSVPAADPYIVPAAQGEQWLPIQDARKQVDANPAGEVESPYVYRLSQQNKTQAPGGGGWVKVTDYRRFAASPTLASAYVHVQKGGLRELHWHKNAEWGYIVKGKARATAFAGGATARTFDLQQGDTWVFPTNYGHYIQNVGDEELEFVEIFRAPNFGEKVRFDDFSLTQWLALVPPSVAAKQLNVSQHLVEQLSSKKQIIVAAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIW0</accession>
    <name>W3VIW0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_04586</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIW0"/>
    <dbReference type="HOGENOM" id="CLU_005138_0_1_1"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="559"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS60686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="828" mass="90790" checksum="64347671F64CF907" modified="2014-03-19" version="1">MPDQPKLAKFFGGGASANAAPSSSSSSAKSRQLDLKSAFAPKASSSTKREATSTPPSTSTDVVPTPEAPEASPSQPAVPQRKKRRIVESDDEDGPDPAPTPAARKQAPVAAIFAKTSAATTPSTLKQSDPIDVTHSDAASDDGGSEVEEPEDDDEDEDDADAQEEEQKGAKKLAAIFQKPSQVRDTKVSWKQGEPVPYAALAAAFSEIQATTKRLEITEILTQFLVRVIERSPDNLLHVVYLCINRLCPDYEGLELGIGESLLIKAIAQSTGREVPRIKKDLESLGDLGLVALNSKKNQPTMFKVSSLKVPSVFKQLRDIALVAGNKSQDRKIGMIKKLLAACQGEEPKFLIRSLEGKLRIGLAERSVLVSLARAVVISKLGKSIAKLPQETLASKLEQGTEVVKAVYSELPSYDLVIPALLRGGVEGLRDECKLTPGVPLKPMLAKPTKAISEVLDRFEGQPFTCEYKYDGERAQVHLLADGKLAVFSRNSENMSVKYPDLVEQIPRCIRPSVKSFVLDAEAAAWKKAELNPDTGVEEPAKLLPFQELSRRKRKDVKAADIKVKVKLFAFDLLYLNGEPLLSRPLDERRQLLLDHFTPVEDEFDYAKAEDGTSVEQIETFLERSVKEGCEGLMVKMLRGPDSTYEPSRRSMNWLKLKKDYLAGTGDSLDLVVIGGYLGKGKRTNVYGAFLLACYDPDSEKFQSICKIGTGFTEADLDAHYATLKQLEIGARKPYYDVGDAKPDVYFDAKVVWEVLTADLSLSPVYTAAKGLVDQRGISLRFPRFIRIRDDKAPEDSTSPEQIESMYRAQAVNSSKSKSALDEDDGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ77</accession>
    <name>W3VJ77_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ77"/>
    <dbReference type="HOGENOM" id="CLU_018310_0_1_1"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000230">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 8 9" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="206"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="348"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="45"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="525" mass="54940" checksum="1F6C9687A8DBDD69" modified="2014-03-19" version="1">MSLPANYTALLNELSRDVAASRPADALQFCANWFNARLEQQRRQHLSGSSTSASNLDNSIGPSDLDFGGVPPGLASPTQRASIFNSDPFASSSRSATEPVPMDASQSPESAYAAPPAAGSSTFNASSSASAPAAAANLPSSIASSAATPLIPPTFNLGRRTSVSAESMAPSGAGAEHDGTPLPKTVIPKSEEHMQRIRGSIGNNLLFRNLEQDQYRDVLLAMKEVKVEANVTVIEQGAQGDYFYVVESGTLDVYVRAPNRGGPDGEAEAEAAAAGGSSALGDKKVSYGPGSSFGELALLYAQPRAATVVSTSACTLWALDRITFRSILMETNSRRRALYEKFLMDVPLFERLSAAERAKISDSLELREYAPGEAVIAQGERGSEFFIIVDGDAEVRKTKQAGREEVVGKLSRGDYFGELALLNNAPRAATVAAAAAATTKLRVVTMSERAFTRLLGPLAGILERHAKETYGDYSGSSAAAATTTAPAVGAFSMSDAADSSLAHPMDSSAKPGQGAWSAPNPFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJA6</accession>
    <name>W3VJA6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJA6"/>
    <dbReference type="HOGENOM" id="CLU_026169_0_0_1"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="520" mass="57157" checksum="0FB1BF2EA3866697" modified="2014-03-19" version="1">MLARSLRLAALRPSTSSRCQPLVQNAASPSFKRAATPSASFSTYGPASRSQSSRMTTIASTAAAVLGTVALYTSLSPRHASPLECEAAKPTPASAIKGGNQSDLPEISHLDPKLLTDTSAPMRKRMETYVKLLQYNIVSALSQEEPKARFLIDSWLRKEGGEGISCVLQDGSTFEKAGVNISVVHGMLPPAAVKQMSANHAGLMDKTGYKLEGKDADVKGLPFYAAGLSLVVHPKNPFAPTVHFNYRYFELTHPEKLADGSPNPRHPKNRKDGEHDNEPIAWWFGGGTDLTPIYLFDEDAKHFHQTLKSAADQHDASFYPTWKRWCDKYFWIPHRGEARGVGGIFFDDLTLPEWASSNSTKAYIALSDGTKPTPSKPLVPSVSSTKQHNQDSLFATVRSLGDAFLPAYLPLVQKRKATPFTEAHERWQQIRRGRYVEFNLVYDRGTKFGLQTPGARIESILMSLPLKARWEYMEKYSGGGAQGRDGKATTSADELDAGDEESGAAEKKTQAALRQPKDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJM1</accession>
    <name>W3VJM1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJM1"/>
    <dbReference type="HOGENOM" id="CLU_068101_0_0_1"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23701">
        <property type="entry name" value="At1g26750"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059242">
        <property type="entry name" value="mS23_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="347" mass="37415" checksum="0928DDB38CBE609B" modified="2014-03-19" version="1">MPRRIPSQVPQTVSRLLESGFLKQQPAWYEAVTNHPPMTVPARHPVKRPDEDLPARLRSTAQTGLAKIGSSSKAAAPANAKFGRDTTNSKKKSRTLTPTLKPKPITYDEDKVRQQFYRDHPWEAYRPKTLVEMSAEVGSESRVSGDAKRLRSYGRDPSVEDVVACTIAAHRQGGLSLSQAYHNTLSSYHALKAEHEHATRYAALEARYYGADLGKSETQRGFEKEDKALESWAAWAAGGAQLGDPATQATEVQQVKATRVKRTDDTFTSGQAYLEAAKAFKEGKVSAERLDSGAGATAQQSSAGAAAGAPNNALPGDSADDFLGLAQSTIRPTQAPASEQQPAAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJQ9</accession>
    <name>W3VJQ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04928</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJQ9"/>
    <dbReference type="HOGENOM" id="CLU_345875_0_0_1"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="482"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="765"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="776"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="886" mass="96785" checksum="165899725075FA4E" modified="2014-03-19" version="1">MEVDLSKRDEVANAGGNPIAFPLLQLISEARNEHGMRQQDYARYRRYCASKVHRLRELLSLTHADGSHKADAKKNKGAKAARGKKPKKVQQAAAQSADAKGHGNVFTAKTLDVAQVNDARPAHLLLFEAERAWAYSQELRSEAFEDDSNPQLRKRGISRLRRAEQWSDSLHQLVQALASRFDAYARAETAAYLLTIKATTAFDRSRWDKALQLLSVNRTLLNAIAANSPTSRAEALANSFVDAGEAQMRYSAYQLGNSEQDMDRIAQSTATPEACEQALPGYAKLLQELAAAKAEAGTVQKQALSLNWHGRQIPVRNPELLDTIVAAQSEEAALRDSVLVEAVNDRDASAATRSKSANAQAKDGKRPRLSHAQRKAKKRELAQGETSADGARNATSSTVRLGKAGRTELDPFDRALSAFTDAEDVARKLVDDNAEALSKSHSARYETASKDLQTAHDFVFYRLLALRIWRNLRLVAEVEQRAEKREKRAMSSVEARLKGKAGTGAAAKRSKRSKRKQQKLDEAAAAKKATPRRNPPGSRAKQQRSAGRKQARKPARSGTRKLRSRQSLARENRARAIAAQKSKRRGARAVPSLAKLLDAAETSLVAMGSIGLIESEPDVSSLVEAKAAWFRSEILRHLARAFSLSGAHAEAVLLLTRAQLYIRQARQAAELAEDVDEEDADFPPRLKSSSGSDAVFDHSDEVLAGLKRGVQKAILKAQQQDQGKKRKAGSTMSDSRAGQALQELARKYIDFDPVSLEDARRVPDEVKAEYEQEQRAASTPAAKAKPTAATKAPAKAAAKAKAAAVPKAAPVKQPEPKAAQPQVVEETEEAETYDEPQDEEDEAEEAGDVSLAYDPGNALAEEEEARLEAEAANKKKGWLGGWFGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK38</accession>
    <name>W3VK38_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05064</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK38"/>
    <dbReference type="HOGENOM" id="CLU_017779_3_3_1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="441"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="881" mass="95973" checksum="95BDF9AEDFFDE9C8" modified="2014-03-19" version="1">MSTGTFDANKAQNLPEIEKQMAVRCVEHAQTYWNLLEKIKPSSLRLTKLDDEMYEDFQATFPEFAESADPKSVLKVDEEAMKSPAGKEKWRVFINKYENKGFKADFIPICLFALSPVADYNFGTLIRTDASDEYTQFNTTFVTRLQFYVYEIARCRRGLNDWVYEKAQKEAAKEKAKKAASGSNPSTPVSSRLAGLCVDLQRHTFWWWHMGKGKREEADAEHGPDLPNVGGREAVGGGAEPRTQPVHHRHHVNLTEQPERGPSRPSFELFFSPTNNPLVLCTVCKMVFARRFSTRAFGAARCPSTPATSSTRRLLTTSAPRHNVTTGGASGSASASPGSYRNLALGLLAVGLGANAYYLSQRDSKLQLDGPKAVVPSGEYSYSNPQLPFEYGSKQDFEAAIEELKAYFTSQGEAWDDFVTTDDDELERRGLDENGHRSSSEGTKPSVAVYVRDTPDVQQVIRIANKYRMPIVPFSGGTSLEGHYIAPFAGISIDMSRMDKVIAFHPADGDIVVQAGIGWETVNQYCAKNGNQLFFPLDPGPGATIGGMIGTGCSGTNAVRYGTARGEHFLDMKVVLANGEIISTRGGGRARKSSAGFDIGKIIVGAEGTLGIVTEVTLRLAPKMPSDAVAVASFPNVEAASQTVNEILLSGVPVQCIELLDYKMIQSINESNLCGRRYDEKDSLFFKLSGGEAAVAEAKEAITRASVKFGARRESVEFETDKERAAKIWEGRKAALWAVAATNEAPGVKVWTTDVCVPISALPRLVRESQKDFQESGLTGTAIVGHAGDGNFHALIPFNASDSKELQTTTEVVGRLCERAQKLQGTCTGEHGVGMGKIEYLEKELPAATIRVMKAIKLALDPNNLLNPGKLYPHPAAAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKA5</accession>
    <name>W3VKA5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKA5"/>
    <dbReference type="HOGENOM" id="CLU_009614_0_0_1"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="988" mass="109827" checksum="996D75881F3B641D" modified="2014-03-19" version="1">MASAPPSQEHLQLVCTILAQTLDPVHRKNAEQQLTRAQSQPGFLQILVAVIQNAAITSNDAVRLAAAIKLKNICKTAWDQESAEESAVAAPVNDADKIALKQSIIPLLVAISTTTTHGTPPAPTNVRSQLEEAIALVADKDFPHHWPDLMDQLVPKLADQDHQLVLGILRTAHSIFYRWRSAFRSDALYSEINYVLAKFALPHLELLTRTDQRLLDPATPPAALPVLGNVLNMALQIFVDLSSQDLPPQFEDNMQPITDILARWIQHARTELDQDPDEPCTLQHIRSSICEIAELYAKRYLDAFPQLPTFVQAIWHMLGDCTLSQKYDTLVSKAVAFLSTVVRMGSSREMFQSQQTLEQLCSAIILPNIAIREADEELFEDNPIEYIRRDLETSMEADTRRKAASEFCRALMEFFATQVTSIVSRYIVQYLDQYRADPAANWKQKDTAIYLLTSIASKSSTAQHGVTATNELVDVVQFFSDNVYADLQVSAHDSPSPILQVDAIKYLHTFRNQLTKEQLLGVLPLLVQHLESEQYVTCSYASITIERVLALRRDGKMLFAPQDVQPFAENILMALFRNIERGQTPEKLAENDYLMKCMMRMLATVREAIAPAHALLLDHLAKILAEIAKNPSNPRFSQFLFESIAALVRYTVAAQPDSLAAFEQQLFPPFTMILSQDVAEFQPYVFQILSQMLELHPGAAGLPEAYASLLPPILTPACWENRGNVPALVRLVRAFLAKDAARIVAQGQLGAMLGIYQKLIATRVNEGHALELLETLFEAVPAEALEQYRRAVLTLLLTRLQQSRTDRLVKGTIHLVAAVALTSKGPEYIVDTFEAVQPGLFGQIAQGILAPELANVGERHRRVVGVGFGLLLTSAKLREPAHAPVLPVLLSAQIKLLLTPSSAAAHEDELWANDDDNTAAATFQAAFSRLAASETQRVDPTAVVLKDAPVHVWFARTLQQMQAELGAQWEAVWNQVPQDLRSAWAQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKB1</accession>
    <name>W3VKB1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKB1"/>
    <dbReference type="HOGENOM" id="CLU_1278095_0_0_1"/>
    <dbReference type="OrthoDB" id="10339188at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="216" mass="23827" checksum="0AE0397AE6CDB2EB" modified="2014-03-19" version="1">MYADARTGGVGSTSRTGWSAVNAAGDTAAVGYGSQASLRAILDSAVRREEAVSMEQLGVGPHRKPRTFASLYDVVARIMCTPTTDEAEEIDPTRPRYVSFDELLSTTHTIESPHNVDDQEAELTGQMERQRRSKRPRGGPSFTKRVKPVARPVKLCPRFARTPLPDWPASSAEESSAESSSSSGRLRLSHLQPFLRDLALLYDDDEDEDEDEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKB4</accession>
    <name>W3VKB4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKB4"/>
    <dbReference type="HOGENOM" id="CLU_042060_0_0_1"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="512" mass="53235" checksum="1892595CAE291495" modified="2014-03-19" version="1">MAPGKANVDKSTTIRAASKNKQRSQPSNRAAASPFGSSAGGSLADSLSSLFSPQPHGKDAALASLLASTSKPPTTSGPKSGLSAFGSFPTGQSSASSKPSPAGPSQLLDQKSKSKQSDTKVKESASSAKPEESAPNKLKGDSSKDAQSRPGPGPDKLPSKPAALNQASASKPASSSAIPSPKPAITQVPAGRRPVFRPVLASSTAVTWPEMPVAGSKTVLHTLLETLASPEVKQAVLKDHGRNSQARSLQPKRQLQAASSAASVSAAPQALAGINSITRALEAEIHTELSSLHADAADGAKQKGKSTALVPQIEIVFVCRHDAASSTLIAHLPMLVAARNAVSAAHTAADTTDARSTLLFALPAGSEALLARALGLRRASVVALTSAFAPTHLKRLLDAVQRETGSVCRLRAAWLETALRAAKPSKPGPLALPRLPPTVKLLRTTQPLDLNASKAANKSRRKERSARWKKRKMQLQQSIRSLRAELKHAAKAKRQAKKVGQSSTDSPMQIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKI8</accession>
    <name>W3VKI8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKI8"/>
    <dbReference type="HOGENOM" id="CLU_020823_0_0_1"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000043">
        <property type="entry name" value="Protein transport protein sec9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000075">
        <property type="entry name" value="Related to SEC9-protein transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="334"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="397" mass="42203" checksum="E3D7047B3CB4FBE1" modified="2014-03-19" version="1">MGLFGKKSSKIPPVESAPPPQSGPPGRYGAGGPGYGGAGPSGQGAGAGYGYGNQGYGGGAGGAGYGQQQYGGAPGGPAPYQDRFANARAPSAGFGSGYDQYAGGSANKSANLSRNVQSGAGGDDDLEAEYGRGSGANAASNAGYDGLEQQEEQRDEEDDEVEAIKQQMRFTKQESLSSTRNALRIAREAEETASNTMFKLSDQSEKIGNTERSLDLAKAHASRAEDNAKEIVALNRSIFRPNIQFNKKAKRDAEEARIIARHIDEREEREAVRRDVTAAQSRLDASMNGPGTGKANIGRFGQDRFGTGKKAEEAQRNKVAQRGRYQFEATESDDELEDELDQNLDEIGMLSSRLNQLGKAMGAEVDSQNSRLQRIGDKATTLDTKIFAGTQRLGNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKU1</accession>
    <name>W3VKU1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoadenosine phosphosulphate reductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03691</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKU1"/>
    <dbReference type="HOGENOM" id="CLU_590676_0_0_1"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000136">
        <property type="entry name" value="Probable phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="9">
        <location>
            <begin position="212"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="463" mass="51934" checksum="3FA0CAEBE8C8B42C" modified="2014-03-19" version="1">MRRPYFDTEIQDLYREIGLTFESIEMSEIFSPERYAAAPPHFEHRSWRLDRGTEPLLSQQGRGDAQPAPHCLRWAQEYCSRACALAWLPQSRSIAHAGLESETSKGASTDAVDQFTVQHPSSSTFHSIVRHFESQKHLQLAIRIRQKASAPSSQHAASIMTTAQVAQSSKQAEQEAQIRAVIANLEAINRKLGEADPTEIIEWAIDNLPGLYQTTAFGITGCITVDMIARISEQRAAKQSRPNHHLVPLIFVDTLYHFPQTLDLAQKAAKHYNAEMHVYYPPGTTTVREFEDKWGTQLWEKDEDTYDYLVKVEPARRAYEELGVRAVFTGRRRSQGADRASLNAVEVDETGLIKVNALMNWSFGQVDAYAKANAVPYNELLDLGYKSIGDWHSTALPGSGDSGERAGRWKDKAGKTECGLHKDYFKMKNLAEKKLREAELARKDEARDKAAASAQAEALSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKV0</accession>
    <name>W3VKV0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKV0"/>
    <dbReference type="HOGENOM" id="CLU_966835_0_0_1"/>
    <dbReference type="OrthoDB" id="2552844at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="288" mass="32362" checksum="B9F106BA51013035" modified="2014-03-19" version="1">MHYPPTYRAVPAYPASELYDVAAQRAYDAYMPRDDVRPHMDESLVKKRTRQRVYPSEEAKQAAKMLQKARRREQNRNAQRRLRDRKEEHIFKLEAEVAQLRRQGEQQRAEMQGLEEMIRRLMEQRSELRHRLEALGGAPLGDDLTFGGEKSMRLAPLLSLPPLGAAGQASPSGRASRRETLADNALGLEYEMPSQSTSWSASPNLGDRERPAVSPVQSSASSASVSTPRSPSSLEPRSRTTSFHATGLRKSQPNFDLPLPRLKMDATNPILPPSLMPLPPVTAPWPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKW2</accession>
    <name>W3VKW2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKW2"/>
    <dbReference type="HOGENOM" id="CLU_081371_0_0_1"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33170" checksum="5DCF7326609A0BE3" modified="2014-03-19" version="1">MDAGAVIAVAASSPSYTSAWQLLFDFAHRHRHPIHHEKLAKKLMLRGNTRSVQGKLSDWIALELGSGMSNLRIGDRNARSHAPSAGAAQPAHSPLAHCISSPHLLHPCASPLPQPNHLGPIPTPFDRHPLVHSSTRPLPRLASHRIAIRLDCIRPLPLLHYGEIPAQPATTQQCHDFDAAQQSQGIQTLLEAEKEAAKIVQKARTYRTQKLKDARNEASKEIEQLKANKEKEFADFQKQHEGSTNSSQTTVDKETEERLGELNKAFEANRDQVISKLLDRVVDVKTELHRNLQLQQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKW6</accession>
    <name>W3VKW6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKW6"/>
    <dbReference type="HOGENOM" id="CLU_003783_0_1_1"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="728"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="792"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="699"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="990" mass="108195" checksum="C56B9334307EA65D" modified="2014-03-19" version="1">MARTQRSGRTGASGASRRAATSTSDPAAPFSSSAYSNQTTNKPRRPRPSADGPRGLHDVYDFAQASTSAATKQPRGARRATAGMHSEDYADLPSQAKGKQPRRRRVDDEDDEDDDDDDDESDDDDTPVGPKVFDSGDEVHDGIEGTDEELDSDEAFGESDDEKFDGWTFGRRTNNKSSRNDDDDDHDAQDGEDDGGMMDLSRMLDSASGESDGESDQDSDDNNSEDDDETSSKLAKHIQSFAAGSKRQAGPDSGSDDQAGSDAEPSAKRSRRVVLSERTEAIPETEFAATHSGSTLRLEDFMSPLSANVDFADVRKSTKLLANAKHPSSAPVASKKGGGALAAPLPSVVQDRLDRQGAYAITRDEVQGWQPTINRLRDAEHLSFPLQKPAKTKASTSGLVATFTPDTDMEASVAAMLDSGGLTEKQLAQQEDLAMNKLDPNEARARRDELRRMRMLLFRAEQKAKRVAKIKSKAYRKIHRKDKERLKAQMAELESEDEDEEDEQAGIDERLKAERDRARERATLKHKNTSKWAKNILHARHGEHNQEARNELEAQLNRGTELRAKIEAREIGDSDDSDDYSDEGDVDDAEVARDAFDELKALEVKEEARRKRDEEELERVGGKKGVYGMKFMKDARERQYAGIRGDVDDFVSEMHQLGAEQAGSDDEVAAPAKAESRATYVQGNKGRAMYGAASANPTPRAVEPPSAPAAPVAVEDAANPAIEAAGVEVGGSARSRKKPKSAAAAADEEESNPWLMIDSRGQASKLSRKKNDSALAAQSASSLAATKSALRASKAASRSESSVAAKRSDDAIDINTSTLLHNSDSDEEQPMPIPRNRSKVVLQQRELVASAFATDDVVSEFAAEKEAAMEADESKVVDTRLPGWGAWTGRGTRGASSNARFVKKVQGVDRDQRKDAKMAHVIIAEKRDKKQDRFTRKDLPYPYTSVAQYKAAMNQPLGKEWNTLTEKQRLTLPRVTAKPGKLITPVARKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKX2</accession>
    <name>W3VKX2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000327_1_0_1"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="1225"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="2074"/>
            <end position="2293"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2881"/>
            <end position="3029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2019"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2823"/>
            <end position="2869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2986"/>
            <end position="3049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2019"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2037"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2829"/>
            <end position="2861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2989"/>
            <end position="3000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="3018"/>
            <end position="3028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="3049" mass="335327" checksum="89AF84BFAA8E3EAB" modified="2014-03-19" version="1">MATASAAQSGKSKKLSREQQRRKADKKAGKIRKVQLDASGSLASAKQKTLKQINKNAEKVTTRFRYASFNQRLQDVHLAPAAISASTSYRPYAGLDAPLASSSSSASAARLQPIDALDEELLDIDDQDASSSLHARTSVSHALQAWTDLNLSNAFVDLYRQLNPIVQSLPQLIHHRSSIASILAAALSSPSQWLAWDAALDILPRLAKDLGSEFLPIYPTMLKSAVHVTTTTKDTTNGDERAAANLVERAFQSSAWILKAVSPFVVSKEKGASVQDDALNESAEDGDIVMVEEDVEEDEVDERTQRLIDTWTVIRPYLGWKRIDVKEAHPSALDAQEEESDDEDTEVQEPEQDDDGTADKAPQADETFRNTNVHRISPFTRRFASEAFAHLLRKTRGRQLHNITSLIVSDLETMLHDEDRHIHFRRQPSRRPSVRFSRGIAGIWVEGCKSLDRRLHSKCTSLLSVLLRPSRAAPNASVAKYRHLTRLILGRLTITALNHHCNATHFAPVLEFVSSLVETNHARLLEHKDGAQHVAHLTESVEWLACAVGVRKGTRVADAAKPALFALLLQLSGSFLHDAVQSPQGAALQTSMVSLLALALPIGRLQDLLGPGIKIVDALAPVASVAKAKHGIEQRQALWPEFSALVEALAQPALGWSGFTQFALPSVLTSTAETLASASTSSHSKDQAFSLLERLEKLGQLDGIRTAPATPALVRWSKHVAAAIEERLAKLVERFCTPSKHGASKAKLAKANVLADQASLEPLVPALRLATVPRTASPAGFGSKIAELLLDGLLSDRFWASRDEVRASFDQHIVNPALLVGQACESLAILQERSAAKDFEATAKMIKDRMEVQRVVRCASWHRGAIQGLSKYLASCPARLRPALPELADVLEPLSEAIMSSDPVIRLAALEILALAETQQLRGLTGFIDKLVEVERTPLSVASIRDRNVRLRSVGRDLGRTVAAYKPADVAKFAERDALVMRYVLANLKVNLRPVWGEAIKALTDIVESGQRELENALFGIAINELEAGRQLDSAEIRAVPEAWTKRNGEEDDDAPGSVDADEVEPDRVLRDESDVAGIDDDKQFQDGILLERRKAVRSCIEHARTGAGRSDCAKSATSAAKLTTTLQACVEAQRPDARLDLVNYRHQILKLFCEVALTVERNNARFVHIFFRDAGPRNHAGVLLSPLDDEADDDEDEAAEDGKAAKKERKPIDPAAMNLGKKDRQAQLTAYLEVLGKLKNPKALSRSTELHTYLLSLCATAEVSVQKLALEAILTWKDEAVLPYASKLKDLLETANFRDTLTTFTLSSDTNVVQPYHRPVLMPLVIRLLFGALLSRRGNRTSGAGQRSRRGAVLGALADVGSEELVTLVDLMLAPFGDQATQLVAEGEKFAFVSQPPVTSTRRQVGYLTLLGEVVKQIGANLLPYWDRLIGVSLNLTFHAHKAVVQVHSESSEGVAADAAKPLTARTSRARLVRQAGYKRLCDFFGKAQVAAAFHWDRYLPAIFAELISPRLDALRVESSQSPSALLELFHVWSSQTETIPLLGTYDANVLPSTFAILAAPNVKPSAIGNVLDIAERVLAAASAEPDSMDVSQDGKRVPLVDLLVRPHASVFLNSVTPLIEQASSATGPAAAAMGRDDLLRRQISLLAALSPFVTEPADASHLVTLLSPMMRKSNFLVPERTKTELLAIFERLLSLIPEFQDKNSDMFRSTFGMLSGLFSLLRFAESRKTLSAAFNRCAEVDSELSRVAQWCTQLNALSRRRVEERDFDQLFAAFDSINAAETHITPKEWQPLVHNFLFLILDPEELSIRSNANASLVKFIGQTAAECSAGADAEDELMQVFLQSVWPGLKKAVRNRSELVRRDVLAVISSAAENLPGCEVMAELSGLLGGGDAEVNFFNNIHHIQLHRRTRAVKRLPEQAAKGGMKSRTISDILAPVLGHFLLPGSVELNDHNLVTEVITSLGLLAGQLNWGPYNALLWQYLRLANKKGSAERIMVRAAMAILDNFHFGMEEETILEEDDEEADGDVNADDEDADKAAAAEERQGKEAERVKILDAVTTRLLPRLMAYLEQKDETEASTRLPIAVGVVRVAQCLPVKQRQAQISKLLKTLSNVFRAKAQDTRDLARETACKVMSTLGAKFLPEFLREMRRALMRGPQKAVLAFTVHSVLTHLMTSKDEPLTSLDQGAKEIIEIAVEDIFGATADDRESIGSKTTYREVKHSKSMDTFEQVARIVTPNRMADVLQPLRDILQQTEIPKMVRQVEECLRRIASGIPANPQFDANRFLSLCATLVKRDAVFLQARKPEAKAASRHKSSTLYNYAVFLKRKDVEEGAMAGKDHYSRNAHKFVAFGLEMLVTSLRRERFDFQDEEVLAKLNGMVNIVGDAAYANESSVLELALRAIAQIVKAPVSRVDKALPVFIKQIFGIIHQYGSPQSQIVQTAFRTLTAILRECKNASLSETHLSGLLKLIGPDLEEPAVQSTLFGLLRAIVSRRLVVSEVYDTMDKVAEMMVTNQSESVRDLCRSTYLQFLLDYPQGKQRLRNQIGFLAKNLAYEHESGRLSVLEITTAILNKFGDELLQEYAEMLFVALAMVVANDSSTKCREKAAGLIGVLVRAMTEAQQDKTSLMVDAWARSEGKPELARVGVQIYGLLLEALPDRSASWAPKALEVVTKVLVECADDLEAIENSEGALEGVELDWQLPYHSLQTLSRVASLGARDRTASTANDAVRRLLLFPHKWVRIAASRLLGGLYAQREPAAPTMVAVQQDPVASLPALVDAAKKSCLQLRSDRLDETLALQVVKNLVWIGRSFALFPVDRAQLASPAPTEDGEDKDEAAEDDEEDGDGSDTEGESSEEDEAVVEGAKRREAAMDAPTAIAADPLRWLVARLSFQARLSLAQSKSETWTIAPASILRFFAALSASLDPSLLPHILSLLLSPIIRLVESPAASTGSDELKALAIEVQTHLQSLVDIAVFNRTYSTLKRKQQAKREQRKTDRLMRGINDPQLQARRNEVRNRKNHAARKRRNQSNLDKREAGGSGKTKRARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL30</accession>
    <name>W3VL30_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL30"/>
    <dbReference type="HOGENOM" id="CLU_008846_0_0_1"/>
    <dbReference type="OrthoDB" id="3362023at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1147" mass="120423" checksum="C5AA62CB1C6CFE8C" modified="2014-03-19" version="1">MSASSPHYSFVPDPHSAQYLAMDARTNDRSPSPARKFWPFNRSRSSSPNTQQQLHVDTSFNSTRSRRSSNNSPAISPSGSASSFVVRSVIRNPGGVSMPGSPANDTAQPFFGQPNSPARRMTLEDSDDEQPQHGQLHYRRSKSKPLGAAPASLGVPPGGPGGGIGYGTAHSSNDGRPEAAGAQPSPYHRPASPSASIKAGEFNRANQRGRSPRKSVSAASASDHDPRSASAHSAASGKKPVARITAGPKSLAQQQHEMQHQQLDQSSRGPSPAAGPRQAGGLAGPRQFPVAAPAGFGLPPMQPPSMPHAQDARDESPSRSRRFSFGIGRTRKDSDTPAAPTAAAAPLDGLPSPVDIPYGRSPHSPLRFDAGADTDYSRANSPFGSVSPARVAGSPNSSGFINTLMGRQSSADHTPSRDDNVPRSCSPGGGSHLAGKWFKGVFGRSPRADEKDAAYADGVLPYPARDAEDEAAVAQKMASMRQARHIVDQERQQWMSAQTPTRAAEFRPRQVVDGDDEDEDAALEHELGRKKSPPGRKPVPAYLPGATVESTPAAASDEPLTPAQRIIHETRSKQLAREQIEAQRKHAADQQTQLRQTRHTQLPPATPPKSTSATGGHGKRFPSGAHQLTREPVHAHPAGAASTLSPGSGPMPAEMGLRDALQEMMVRFYRFERYSVPLIRALERRLVDIERDAMLASNPHARGSVGSASSAHSAEMDRWVTQMTGLMKHEVGQLKAATREISEARELVAHVARTSPQEAAKSAAVPVSTSMSSFGSIHAVTPSASVQPMPQVLESPAKARQTNVSSSTFESAVPRAGAGAAGVRNLVLPAGAKPALDKDEGKHSTASPTKAIFGFASESVRERDARERSVSPNGRPRFTSVLGQPLVHGRLSPGPTSPSAESGMKRDVSVEDRLKALVDGASTRSRSSSFASAAPATLSNAEEEDDDSGAADITAALAAIEATSHGKKPSTHTLDTLREPVAVTKSASHSSSGSVEEPLTPPLEDAPSAPGASPVKTRALSYLSTAAAMDEPKCAPAVASGRISPNKLFAHKFAATASTASAHSAHSANSTSSPSAKLGLVEKKRFTLGAPVSPVSNGRLSRTPSATFEDTATVAPTSAAFSALAKVKPVGHTATLRERVAFFDTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLJ3</accession>
    <name>W3VLJ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cut9 interacting protein Scn1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLJ3"/>
    <dbReference type="HOGENOM" id="CLU_031506_3_2_1"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40917" checksum="F0019E71283E286A" modified="2014-03-19" version="1">MCAGGSETSMQADLTVEEPPEALAELFVDSHCHPTDDPAAYTEANLDELSRRIQDSAVGKLVCMSTNARDQKLVAELASRHPLKVVPCFGWHPWFAHQISLSDPAPSKRDHYYQLFGLSDGQVDDRGDLRIELDSMWDHLPDPISLRDVCDEIEGNFERFPNALLGEVGIDRAFRIPRRAWNYDPQKTAEDKADQPRLTRLKTPQAHQMSILRAQIEVALRFKRNISLHSVQAAGLTVDLLSSLRNTDLASFGAIRLSLHSCTMDTNVVKSIAKKHANVYVGFSSTINRKQILQKECLAGVDRTRALMESDHHTVRNIPACLLQASRYFADLHGLSLEAAAQQLRSNWNAFYSSTYCQDQDSDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLN0</accession>
    <name>W3VLN0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262145_0_0_1"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="953"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="11">
        <location>
            <begin position="128"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="622"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1292" mass="142233" checksum="1D6A83D934CCD13A" modified="2014-03-19" version="1">MTDPSTLFQPSDASSSVRKLTHNPTSSWRSYVFMQLLLRAAIWLRQRRARQAGDGNLHPPGPQDFSELLKAYETGKNKYARQHGVRLDWYQPSSESELFASVFRFDWSAIRVLRFQPKAGATNAQRTVVYLNGGGFVQPATTAHGYMCSLLAHRLNAVVYMLPYELAPAGIAASELPRLTAFYLAISAHARSLGQEIIIAGDSAGGSIASSMPLCIQRFAPRLLSKPLLSTEEIGKLQPDQLILLAPVTTCNVTGDIVEHMDRMQAQDWWLDRKRVQELCKMWVGSQSVQDTAVEQLASASDVDGAAEKWRQVLPLQADDAMLDPIASSSLFELLQEAKVHVTLSCGTSDILYACAYYFAKRCEQQQVDCTFIEGSGGVHVYPILGFVISDPGCIKGSDLVIQSVLKASRPWRMAEHGRDPDRCMAVQVSWQGNADAVSMIRSALKTASLFWSAGDWTMASWLKLGGKRPTLLLRCCVLIAAELAVNALLWIVAAIVFRQRPRFLTLCLLAWTLGLRHGLDADHISVIDNATRRIVSLSHTGSLRPRRPVTCGLWFSLGHSTIVVAVICAIAISLGIVDRLGKVSSVGGVIGASVSGSTLFLFAVVNSVLLYQSFAASRRHRRASPRDTQQAWTPNASPTDEDKMPAKATDADEEPRDDGKAADHRFRGIFTRIAYPLFRLVDRPYKMYPVGVLFGLGFDTASSIALLGIAGATNTQVQDTELGSGDNILPTDATRRSDASIVLLALLFTAGMTLVDSLDSVLMINAYAPGELLAPRSEQDSGRWGWWKRARFLEDASQVAREKSDVTTSEVDAEVDLDATTERGTGSMLSQLLTLLSILLAFAISIITLMGLIGENCDRCARAASKQDDTHDGGLEGRWWLFWQQANDASGIIGACIVGGFAAILIVWYAGRAILRRHAPRTRLCYYFTSIAISTTNEMTAASAAKPTGSSALNVSTLAPLGALTVVVSPWGFSTLKALLLEPIRINPPVWLRILLGLVVLANVRSTPFAWHLRVLYPAFKAVFRARPWLSTPEPHALTHAAIKPQLKTSKLPLGKDVFIDTSSHNFVATLDECDWNGHLSNSSYSRSLDYTRMAHNSPRFLKLYYDGGWVALGGSAFNFHREIPLLARYTIRMSLEAWDDKWLYVVGRFVAPAKASAKNAAASAPTNAVTEMLQPGEQLYCTSISRYVCKSGRRTIPPWLAIATSGYGTHEATRSNWQKAEKLRAYYLEKEKKAYLAKSGKKPVIRAVDPVGRYDYAQAALISSYWDWPAGERPYWSKNTNHLLLVFSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLT4</accession>
    <name>W3VLT4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03826</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLT4"/>
    <dbReference type="HOGENOM" id="CLU_019533_1_2_1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="136"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="485" mass="53520" checksum="0796101808B53299" modified="2014-03-19" version="1">MTGPSGTVTPSEEKSFSWSPSSQVPHFLRNHYRTSSNGHSTPGFPSSGNNSAASSAIHLPNSNSYSSGGTSEKIEPSSSFQTVPVLGAQAGNARSTQPSSMAGVEDTGSKQAGKQKHSLAFGFFGLLSVILAAVVIAFGWINTPQQKLCLAFEDDFSGRTTLNTDNWEYEVRTDGFGNHEFEMTTAQSNNSFIEDGKLYLVPTLTSDEIGETAITGNYTYSLNSTCTAFPQTQGACETSSNATLGTVIQPIKSARIRTKASISRGRIEVRARLPVGDWIWPAIWMMPEDSVYGEWPRSGEIDIVESKGNTVQSLQDRYQNSVTSTLHWGPSAVTDRWGLTTSNFSVPRDYFSEDFHTFGLDWTPTSLTTWVDKPSRHIMKLDMNRDFFAFSRLSHLLWNGTAIQDPWNGKKGAPFDQKFYLILNVAVGGTNGYFSDAERNKPWQNAGSNPVADFWAARTRWLPSWPSDPKKRGMAIDSVKMWQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM52</accession>
    <name>W3VM52_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM52"/>
    <dbReference type="HOGENOM" id="CLU_512025_0_0_1"/>
    <dbReference type="OrthoDB" id="3364425at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="532" mass="58248" checksum="4AEEEA18005EEE30" modified="2014-03-19" version="1">MLDRLPLELQAYILVFLPAKVLVRTLSLTNHHFHDLVEAHIQRYCLRYLGIGCHSADPDDATVLEFEAQRPIDTVTAKHTLHFSHFASVTPCAYSKRQPLSSAAVFQFANGASSRVTTDSERLRGGRGSGRGRGNSVSVGPERIRTGANPYVATPFQPFLPGLHQNDQQRAMQTLVSSSLDLEERLPSRPGLSRNPSSAASLRSRSRSSSTASTSRARAIAHEIASAPFPFLRHNLEAANRHHLVRNSTSSARHTGEQAQTTAPGPSLEEPLDAYDWAGPPGTRAAPAGLEARLPRRAAHKPACYAFQLDPLDSFESLILTLTARRSIQDTNATIAALLRGDEAVNHRLRFSKSLAEGLDRVFRDWFKPKPIGESRGELYASAGRSERILPEQEPDARVLEFDTTSCTLTIQPHASARAHMAHPALSATASHHYLSRPPLSAQYASLESSERVELTFHCQSIAINAARLLATLERLEHDVLATKARSRLALSTLPKIIESVAHDRQPFQVAAEANASLGYFMISQPPPRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMG2</accession>
    <name>W3VMG2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase invovled in MEL production</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMG2"/>
    <dbReference type="SMR" id="W3VMG2"/>
    <dbReference type="HOGENOM" id="CLU_556644_0_0_1"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF2">
        <property type="entry name" value="ACYL-COA-DEPENDENT ACYLTRANSFERASE MAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61437" checksum="A173C69AAEF0CD83" modified="2014-03-19" version="1">MSAQDTYEWQQTERDVWTRTCLGHEASASFNENIAYGHTELSVTATFRVHHPASSGIAGTDRELDDLVARVRDAWIRTRYLRPEVAVEMTTHTDISMPQRFTYRVLRDEASLRRWVEQTMVVVRLGEPGAESLEEVCAYTYNRALPTPGKQSMLYLILPRLADEKDRNAHFVWNVSHALADGGSISELYNVLLQAMIDAAPSTDGSVYIPSDHELDVLPLLPRSVVAAYRQQHKPSAADEEAAAETARDNLRLIQAKMNESLALQPVTNWTTRKHETICIRRDIEADDARELIKFGKHIKSGVTYLASAATVLATAETFPERKASSSGALMGMVRNARRWISTETVEGATGNRTPLGSDAVFLWIPVDTQKSLEPSFDRLPQLVSLAARIRSELNKHLVSPHCISSYPVVADFAQGALTNHWAEIEVANRSAHTPSAEELAKIIGPQAPGFSSVGALQVHKRFEPVSPSARASGLWLERTDAAHRGRQVNASPWISMLMIDGKIKLQLGFDAKFHDAVKMEQWMQRTYEWLLVCAAAASSSSSASTMAPISARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMG8</accession>
    <name>W3VMG8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMG8"/>
    <dbReference type="HOGENOM" id="CLU_054441_0_0_1"/>
    <dbReference type="OrthoDB" id="2542103at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834691" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="111"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="410" mass="43879" checksum="AA22677C18F0B009" modified="2014-03-19" version="1">MKVSVNLVLLASAASVVTQTLAFPNIGAMMAPGPDGAPSHFEKRLLSADPFQLGNLISDLKSKVEELTKEAKVNDAGELLNTKITDITADKIYSTFGVRRDGGLLPPAEDAAHPWQPPPAGAKRGPCPGLNTIANHGYIPRSGVVNPIELLVGTFNGLNLSPDLAAILAGIAFVGMGDLLQMKLSIGDRYGLGSGLSHHGIMEGDGSVTRKDHYFGNSWEADPQLVAQFINETNTYGNGNVDVISLAHSRYRAWDSSRQNNPDFDFNPWRMLVAYGESGFVHEALRGSSAKFDECMIRSWFLHERFPEGWSKRLVPVSTPEILAWAGIIELAKPTIPGWSVGKKGAFVPLPTTDAAYQELRSLIDPKTSGATLGQLVCAAGNAVLGFFPTPITNLLGNFGINGVGSTLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMI7</accession>
    <name>W3VMI7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMI7"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="60"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="578" mass="63491" checksum="A77E57DCE7CFBBC6" modified="2014-03-19" version="1">MASTDGIASTPLSPDMEKSSIPSSDGYAKAAYNDPSAIERLGMDEDSPDGHVQRNLKQRHLSMIALGGTIGTGLFVGLGGSLANAGPVSTLIAYMIMGVVVYSMMVALGEVSTLLAVPGGFTHHATRFLDPSLGFALGWTYWYSYGITIPTEISASAIVIQYWDTTQSINPAAWISILLVLVIGVNALGVKYYGETEFWFCLIKVVAIIVLIITSLVIDLGGGPRGDRIGFRYWKDPGPMAQLFWQPDPVTGRPTGGISGAFGRFLAFWNVFVQSAFSFAGTEIIGVAVGEAENPRKNVPKAIKRVFWRILLFYVLAIFMVGLVVPYTDPRLLNGSSDASASPFVLAISNSGIRVLPHIVNAVLLVTTWSAANSDLYAASRTIYALALENKAPAFLRKCTKNGLPVWALVVTSLFGPLAYMSCGAGGAEQAFEYLYDISAISIIIAWIIILCTYARFYHGLKFHGIARNTLPYTAPFQPYLTYFGIVFLSLVLLFAGFTVFLNGQWSTSSFVTTYICIPMFVVLWLGWKFYHKTQFVSLSQMDFDTGRRQIDENEEAEKIKESQITRSTLERFWDWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMK0</accession>
    <name>W3VMK0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMK0"/>
    <dbReference type="HOGENOM" id="CLU_390391_0_0_1"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="8">
        <location>
            <begin position="563"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="420"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="798" mass="88456" checksum="B0F467524C30C519" modified="2014-03-19" version="1">MPPRTSARGTPTPRRSPRISARSETPDARHAAAPTTPRRQLSPEMSRQLSPAGAGFQSRRPLPNLGALAGASMNTSIKQEDASTSYYVREPSNHNGTTSPAPYQSSLLRGDQRAFNDPRDVSHSHSASLSIFSSGSSDLTDYQQEEREAARMQTNGSRIQPPVQVQPIVTRRVSAQRKARTSLDDRPYRPGSDDDDDDDDNIGSPTRRRRKGRNSGSLSAYDQGKIDNLRWRNGTAKGTTKKSRGRNSLNSQSAEHDVNSGSEDGQDDDDDDDDDAGAASGKETRFDGASDEEIDEPVALVAGKPAEATRPQDAQPNQPSLPVRLALGVFRLLTRLVGALLSVLLWLPLVAGRKLWRAVATTSWKDLLARLAFLLTIGVAVLVAYGFGCGGIEGLSLRFPSISPSHPVSVPSDGDFLHRTSLLDRENRRLRADLQRLTNRLDELSSSIESQISSRLQTASAKIVADAEARKDAELSRLTASTKRQVSRLAQDELRSIQESVSNNVETMLRDLDRKIDGQLKRRADDTEGKFFAQLEREVGKIAKYANDEVNAKLAQSFDQTFLSELIEDRLERYSRDRTGRVDWAAVTSGAWVGEQGTVHRGYRYNSVWNLKAYLAQGRKVPIGEPVKAITPGAGLGADNCWMTGWNSMIDVNLAAPKVVDEVVLEHPLPGMARTAPRRVIVWGTVDESDRDYYRQYRRKLAPTAREYFAQVLPEPFLSAVPAEYADEAPLLLAWFEYRADGNTLQTFNLTDEAKAYPYGVEATRWQFIDGWARNPPLCIHRLRVHGEQWPLFAQQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMS0</accession>
    <name>W3VMS0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMS0"/>
    <dbReference type="HOGENOM" id="CLU_021430_1_1_1"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="71451" checksum="3E214ED2B3B48495" modified="2014-03-19" version="1">MLPTHFASAAVSAQHAEQATMVTYPPTPNGASAARPVDTTAPSAPSNPVVRRVLGSRGIASLTIDTGALSAQAAKHNGTAPAHSTATAPRSAKRGRWHTLEFKLYYAVFVVVVPLMVWVPMRLSRPSNPNYYTYSGHLKPGWIAGRLRDDSDFQYRSFRDYVPALVGIMGVYLALSKLFTWLPSPAPRYSRVDAAASTSSPNRKAFLTVFTAIFVFALHGFNSIKLLLVVVANYALSKAVGGTRVAPVAVFGFNVATLFAVHWNDGFEYARISPALAWLEVFKGLLPRWQINFNITMLRLVSFGLDYHWARCEAKAGAAAGRSMGEVEREQREASYVERTRLTQAMHEYSLGTYLLYVLYPPLFIAGPIMTFNDFAHQLRRPCAIERSTVVRYAARFVVSLLTMEWILHYVYVNAIKDAKAWVGASPMELSMIGFWNLIIVWLKLLIPWRFFRLWAMADGVEAPENMVRCMANNYSTLGFWRSWHRSYNLWIVRYIYVPLGGSRNQIAATLLVFTFVALWHDLSLKLLAWGWLITFFIVPEVVARKVVPYSRYGDAWWFRHLAAVGGVGNVLMMMTGNLVGFAIGTDGMRYMIEQLLGSAEGMQFMLAACATLFVGVQVMFEYREEELRRGIDRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN67</accession>
    <name>W3VN67_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ergosterol biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02781</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN67"/>
    <dbReference type="HOGENOM" id="CLU_114589_0_0_1"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14888" checksum="B09BE0E1A64A035C" modified="2014-03-19" version="1">MSTISEWIPEGLLPRWLLLVAATAYAYGASNFLKHTAGFKVYSNGGAQVTPLSGRLFGIWNITAAIIRTYAAYNIHDKVAYELCMWSFVIALVHFVSETFVYRTAKLSPGIISPLIVASSSLTTMYLNYGHYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNB7</accession>
    <name>W3VNB7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNB7"/>
    <dbReference type="HOGENOM" id="CLU_056420_0_0_1"/>
    <dbReference type="OrthoDB" id="3361196at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834386" evidence="2">
        <location>
            <begin position="31"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="407" mass="42479" checksum="B5407E376A45A5F1" modified="2014-03-19" version="1">MATQAPARRRGAKLFFVLLIMGMLAILAQALPLQDDSSNQAKGKRSPMPTPLPRILSLSPRSTPDEVYAFYSPRDVVLDDFADSNGLEKRGTPTKRQDQPSVPLSSLGPPTFPANIPSCPKCEERYSSLSSCMGASSVFANATSIFSDPVAYINVIKCACTDTFQAVYPQCLDCFQHTDQCYYLGTDPQGTGANKVISNLRSICGLGSALLGGVASANNNIGTNVPVNPPSYTDVSTTGAGYKDSTTGAIFQSSGGRSIVDDALHGLGLAAVAVAATGLALLGVSIDDDDCVSACHAGYLAACGTGAAEAAEALSVISRCSYTHEVEERGVGMGFGPGVPAPPARDARWVELGSSATLSGRELTFSPLLYIPSPSTRTWPPLSFSKAPAHLLQTSDPSHLPATLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNC6</accession>
    <name>W3VNC6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNC6"/>
    <dbReference type="HOGENOM" id="CLU_1835984_0_0_1"/>
    <dbReference type="OrthoDB" id="2556771at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="140" mass="15068" checksum="3F0A253A83C93669" modified="2014-03-19" version="1">MPVLMSRTHKPDSTNAASSSSSSGGASTRPRSIASTRSTRSSHKEAELRARWEMAQAIQKPWPLHLLENGTKTNPAPQRSEKKRASFSPPPPAADETKKRSSISGSSTASFTNWIRKKPSPRESSPESASTSPSSSPKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNG5</accession>
    <name>W3VNG5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNG5"/>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150127" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="584" mass="65207" checksum="1C32B08DBD77139D" modified="2014-03-19" version="1">MKLLPSALLLATMAVYETCARGLQHVGKLNSNYKDVHQRVAERNSRLMANKFSASAVTGEPIHLNDKTKPFAVNGTGVPEIDFDIGESYAGLMPISKDPNETRKLYFWYFPSKNPQASNEISIWMNGGPGCSSLEGLSQENGPWLWQYGTYKPVPNPWTWQNLTNMVWVEQPVGTGFSQGKPNISTEAELAEQFKGFYRNFADTFDLHNRSIYITGESYAGQYVPNIASSMLDEKNKEYFNVSGIMIYDPSINADSITEQVPTAAFVDYWGGLFPFNDTIKQQIRDMDDKCGYTAYMNKHLTFPPKGKFPDPHPPTDDCLIFDFVFSAIFDANPCFDIYQVATTCPILWDINGGPGSGDYLPPGASLYFNRTDVKKAINAPVDYPWSECSTQNVFTTKSGLDAGAEKGHLSSTTVLPGVIDRVERTVIGHGMLDMVLLMNGTLLSIQNMTWGGQQGFQQPITDDFYVPFHNDFQEATLAASGIMGKTRTERKLTFVTIDLSGHMVPQYQPSAAYRHMEFLLGRIPSLSSREPFTFFDNGLVAQNGAFADKRATSEDKAAEFQRKHLEYRGLAQPEIAQIIQDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNL1</accession>
    <name>W3VNL1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transport protein USO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006318_1_0_1"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="440"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="7">
        <location>
            <begin position="1272"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="784"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1056"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1314"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1357"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="869"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1330"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1371"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1383" mass="149075" checksum="2A58E1472B75EDB4" modified="2014-03-19" version="1">MLHGFNILRQQYSNLAKPGGGNQSAVSTIQTLADRLAKADENSINIEDRRAAVLALKGLSRDHNRAVGEHALPALLTSLQRDAKDEDTARALIECCITLCEVQPADSAASNPNHNQQTPKRKLHEQGPPPGLLHTDVFLEQPGPLHCLLPLLAPDRAFYTRFASLQLLGSLLRNRPHRVQDHVLVAPGGCGAILECLAEGAGSSAEIVRNEALLLLPHLVHGNADIQKLVAFEGAFEKLLDVCAAEGRVEGGVIVQDALEGLEALLRYNVSNQNYFRETLSIPMLAPLLFYPPGPANNEFASKHAEQEYARQLEAFCFQDWDQQKVTNAKIVLDIAALLIGGQGDGRRANQGALLQCGMTKCLLDLALASTAPASLKAQALHVAASLMQASRPNQDLLSTLLVQPVTIVAAPTPDALERQSGELEHAAQPPTPEVSFSRSEPKPAVVCLVDTAIGTSGAKGALGFRAAAIACFRAYVADNMDARLAIINGMAPDADDKHDGAAASAAPAGKVLLEAILQNPSTHASSANADAYKHLVAAMLFSYLLRSSETAKKAARAIAVNPDGSIVRNARADQDAAADDDDDDDDDDDTPSSPIQVVVGNLTLSERELADAVRKERASAMGATVSSASYSAADWTRIMIGYLVLLSVWLFESPLSVRDFLSESATLQAVIQPVAQSSGVDPLIQGLAAFLLGVAYEFDTDPGKAAVTRETMHPILHSRIGADQFAVRIGRVADDVRFREVTPDVLEKLIVIEEQAEADELRAKQQAEARAAAAAAAAAAAAAKASDPSAVSPEPAKPEDKEKADEEAQDKDLEVNGLGHLSKRRRAGLWFDWSFVEFWRANSTLISKTITVDPASSSAAQAAVPAELLDAQRQAEALRDTVAKQAREIEVLEKRIEELSAQHAKEIEALRSQLDTAETTVSSHAPQLQAAQTELEQLKSAHAAALADIQARHDALAAQLEETQAREESSNGKVLQLTSEMARISAGKPSQKEFAALQKAHDELKKKQDAEASGSGNTAMKDLLEARELATKRADEIAALQEKLAALEASTADRAPAQAQAQGEGELQKKLDQALREKAELESKAAELQASSAATSKGEELQAKLDQALREKTELEGKAAELEAATAQIAELKTQAEAKVALEKKISDLEASHTAAEGQTKQLEELSQKHATLETQLAALDKVAQEKAELEKKLKTLEAADAKAKDLEKKLADLGKIEKEKAELEKKVQTLGAVEKQKKDLEAKVKQLEKSTKDNKQLEAKAKQLDQLTKEKKELEAKLKTFDQLTKEKKELESKAAQVDKLTKEKTELEAKLKSLEGASKSEAGAELETLRTEKDEIAKENEDLLVLLEELTQKRKKDKAKLKEKGEEVSEDEDEDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNL5</accession>
    <name>W3VNL5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coupling of ubiquitin conjugation to ER degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02939</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CUE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNL5"/>
    <dbReference type="HOGENOM" id="CLU_083690_0_0_1"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000050">
        <property type="entry name" value="Related to AMFR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833260" description="Coupling of ubiquitin conjugation to ER degradation protein 1" evidence="11">
        <location>
            <begin position="24"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="12">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="226" mass="23510" checksum="201A03FFA3295E31" modified="2014-03-19" version="1">MNDSLGALIAIVVLWSILRFAFGGGNNNTGSGNAAPALNTARSRQVPQHMVDSVKTLFPHISDASIRYDLQRSGSVEATCERILNEGGLPSPPAGFFGTAEPSTPSNAAALRAQNANRSPNGAASASASSVSTPSKSPNLISRYGLQSRIGQEDVLSTPDSRASTSSQGSPSAWATTPEARAKLLQDRKAQMILEARRKLMERQQSAAKEAAEKASTDSAAAAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNM0</accession>
    <name>W3VNM0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNM0"/>
    <dbReference type="HOGENOM" id="CLU_2251207_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="104" mass="11075" checksum="B5D567042E30B5F5" modified="2014-03-19" version="1">MAAPLEIPAPLLSSTGALQREGCCLAVPGRRLIPRSRVNSEDSDEAAAVSATFKQMLREANDQARALSSKTNVQAAVALHFHDSHDDGDEPVVTAPVSRRAKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNP3</accession>
    <name>W3VNP3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263599_0_0_1"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="353"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="890"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="617"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1081"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1248"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="627"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="761"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1084"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1113"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1124"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1141"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1333" mass="143073" checksum="A676DF89BCB64D73" modified="2014-03-19" version="1">MSVKNGSPVLQSTEISAGVTSSIIDIPPAGQDGLDAQLAVTGSIDGSNGPAAPIPIPSTQARPAKQILAQRHASNTFYRSCEISFMEPVGSMSISPANRDVVLAARKGLFIIDLEDPFAPPRFLAHMTTWEAVDIQWSPHPARSNWVASTSNQKLLIWNLDRPGDPRAAAPLTRLLHRGSIHSSSSPVMPSNAHFSTQRSSAYQSVYNSHSLHSGVTGGTRSGFGAIPTSSPYGETPFSVPSQLQLASSRSSAIEHVLHAHTRAITDINWSPFHPEIVASSSIDTWTWVWDLRMSGGSDAGGRQKPAQGYSAWNAAATQVKFNRASEHRLASTCDNKVLIWDDRKGSLPLATIEAHESKIYGIDWSRDTSLGLDRLVTCSLDRTVKFWNLASDTSQAAIGARELVTEAESIIETKTPVWRARHLPFGNGVMTLPQRGDTTLSMWAKDDAEEPKATFAGHTDIVKEYLFRAKGGQDRESDDRQFQLITWSKDQTLRLWPVSDEQTRKVGHKPGNPIRVLLTRANAPDVSYRDPPLALPVGGEDAAMVASQASGSNITSSSILPPEHATRALLSGKGSGSKIQATSPYSSSMSGFQNIVRDGRTSPLAPFATSVGAARRRSLHHSSSHGDLSTDLNQFSRSPNDTFGRSWGRLDAQQAFTGGSARAQATQMHQLARSLPKHAGEGGGGRFGASYQSSRHGGGSASQHSGGQSSFKVPASLRSKTASNSASASKQRPPNPGRSSGRPLPIQEEQHGAGKKSRRHGDSTQKGDKAARKEERRRLAKAMDPNATKKAVGAAMRLDRGRTAAPAVDPIEWIANVRLENDETDLDRNASEDHAGDDDGKKQRYDGHVASGLAAGKAVRSAVGFGREGPSTEDDTDGEPGFTVQGLGDEIIGINRKLPRIVFEKVELNKRMCVLTMYGPWADHEPAFLRMRIKFPASYPHRAPQFDLEKSANLSLKTRSYLLRGLTRLSSRAARAGTPCLEVCARFLTGEPIKSLDGTDRAGRGENEEDDAKADPTTSRAEGSAASDTDSDTGILAFRPARTAIGSGAEIIKLKMPARRMGASFGPNNELVVFGGSLNQYPQSRDSSRQVSRQGSRSASRAPTDMTAGARSKSKAAMKRSQSKGASRPSTAGTQEGDSDGARGRKGADEGEEESRFLRSYTALSNAMSSLAYYSRTASEGVTTGYSVRDSDVVQLMSTDFFARRLLRKKDFFNIFDSVADADAKSGVATPLARDALVARQKAQTRFYSGSGASTPGARRTGHGDGGGADAAGSDDEQSAAANTLHHADLLGSLPAPAALLVLDRLKETQRRRKMGLVTIYQLVETDADAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNY8</accession>
    <name>W3VNY8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNY8"/>
    <dbReference type="HOGENOM" id="CLU_1723168_0_0_1"/>
    <dbReference type="OrthoDB" id="10300026at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="152" mass="16211" checksum="FBBE59BAAFE60A4C" modified="2014-03-19" version="1">MLRTFGLAPQTSPQPAGADAIRRRREMHFGPTLGTVIPRDSMGGAEKGKHVSLTVIRGAGAAEAGVETQITIDQQMLRARLQRTYEAQCWTGGELSPSFVGYSTPSVQASLSEAGDTRIEISETMTPRASLERQAHVPVAPVKEGRLGPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNZ1</accession>
    <name>W3VNZ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiol methyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNZ1"/>
    <dbReference type="HOGENOM" id="CLU_056435_7_0_1"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28401" checksum="994C889631C8554F" modified="2014-03-19" version="1">MTASISKDDQVQKLRKLFASSDIPNDAKAWDQAWIDSTTPWDSNRPQPALVELLSGGHDADVKVEDLNGNLVPVSKVIPRGSGTAVVPGCGRGYDARVFAERGLTSYGVDISSNAVAAADQWLRNQNLDSDIGSNVNFVEADFFTLGTDKSAAKALAKPAQAVLAYDYTFLCAIPPSLRTAWAETYTRLLAKDAILISLVFPIHGNRPGGPPFSLSPDLVRELLGSQTTAQGNPAWQELAELKPKGPETRPDVERIMVWRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP19</accession>
    <name>W3VP19_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP19"/>
    <dbReference type="HOGENOM" id="CLU_021928_3_1_1"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="212"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="749" mass="79762" checksum="8F2A642699B0E6B7" modified="2014-03-19" version="1">MVGARRWLRTSALSVSRCSHPSQSHTLAFTTASGPRRSPSSTTSSTSASSASSSSSSSSSGSSQWKPPPPPPSGSTAASRKQSRKEWLLVGVAGSAAAVGSWYYWSNIRPRHQANKAAAAALAANSAPFSITAESRTSFSIPTRQAQAGGPTNKVVSTLTNAEVDRRLTENQRSTRVDRPQGACLVARYDTNSVASNDPIEDKRAEVIVERDRGVADPRPSSASSSPATTTTTTNTPNTASGSLNGDLCFFAVMDGHAGFHTSTLLSQKLIAFVALELDKVFREAGEYAEIAKAKSAMPSKLWRALVGGSSRTPSASGITSGLDGDPEIVKRAIAKAFRGLDKEIVNTPVELLKEYELSLASTSSSSVQPDGGAGSTRSLSSLAHTIFPSSTNATFTATQKSAYESILPALSGSCALLTYIDSARHDIYVACTGDSRAVAGYWDEDTGKWEVEALSVDQTGRNPDEVRRMRAEHPANESENVIQRGRVLGGLEPTRAFGDARYKWDRELQGRLYDAFLPGGRSSTRGPPRGLETPPYVTATPAVEWRRVGETSSSPNRELRFIIMATDGLWDMMSNEEAVSLVAGHLAGIKGTIRSSELQRHTFQPIDKQHSLPSNAGAAATSSVAAGANAVQAVAGQAVVQTPVRAASSEEQRELAVSKQHPLSKGPEPLRTFQFQDDNLSTHLIRNALGGANQQRVAGLLAIPAPESRRYRDDITVNVILFNSPTSTPARPPTDPEQHAQEPVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP89</accession>
    <name>W3VP89_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP89"/>
    <dbReference type="HOGENOM" id="CLU_1215223_0_0_1"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="228" mass="24044" checksum="6D435D5916670947" modified="2014-03-19" version="1">MASLEDTDDLYADLYGAAEGGVGDVVDLGGEDKDTAKDEQDLIGYEDDDRKDVGGDSRDAGKSGDEAAAAPSTSSFIPPPSSAQQQQQHGGGMQIKGSFIPPPESSSQAHGDVRDLTPSSRNDASASAYDAGAGVYGGQQGAADANRNDNRELPPHEMPEEGRAIGFGIPARSWTMVLQSGSIHLASTVIDLLHSSLYRLPRSFFAVPLIVTALHRIVSYRNVILFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPG3</accession>
    <name>W3VPG3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1228"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1637"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1644"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1710"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1721"/>
            <end position="1734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1734" mass="193652" checksum="47CB30C9C3016546" modified="2014-03-19" version="1">MADNDKVPAPYFQDDEEGAPSDEGEGVDLMKSDGNLVGSGGEDSSDEDEEDDPEEARRVAEGFIAEDDEEDDEDDEARRERRRRRKKKRKQNEEDFEVDEDDLELLAENTGQAGRKSAGRLKRFRRGSASPPADDEAAARQKTLDQIFEDDDDDEDDDIRTGRRGANYDDDDDDLPSVGNALRAGVARKHRDTGAGYEDDGLDDFIEEDEDDDEMQGLDEDEREARRQQRREEKRKARMSGSAADPAKAGIDREAWDEIHEIFGNGEDYYWALEDDDEDAFDAENKNKMEYKDIFEPAQIAERMLTEEDERIKRIDIPERLQLACPGEEGLKLLERKLTDPELFEAAKWASTRISAKSAAEFLDDAGLFFRFRSEFLNAVQLMLSYMLNDLLEVPFLFQHRVDDLEHLWYDETIGDFQRTILLNRRELYTLSALGLKFKTILIRKDQLRATFNKIHIDVKAEAGNDGVTAEGEPKQEDARAQASRNQRAVFEDMLAQASSLEEISDITEWLTLRYGQKMRDAQALASSTAADSAADDMDGLTIDGEPVSSATPGFKKPSLVGQYERTKNTVLSELAKKFGISSDELAANISSSSRQYSPRDPEQSPFKFAEQFTGAAWGAQSPEIALAKAKMMLSQEIGKDPILKREIRQLFKDAAEINIEPTERGMTVIDDQHPYANFKFILNKPARLVPQQPAQYLQMLQAEDELLIKLDIGLKDVVLSRFENRLYTNYASEGIGEVSQAWNTQRREVIQEALKAHLVPNGRLWLKEWLREESRETLLRHCDFLMAKRLQEGPFMSRSMAARNANPKIEEEDRIPRVLAVSHGGGDPRKDVVQAVYLDERGRFREHATFDDLRPLTARQLQERELETERTRGKAEFVDHRGDFVKLLKQRRPDVVVVSGWSVRTAELKKNVRELVDMAHQEICDDDRLDSESERNQALIDVVTCHDDVARIYQHSSRAAEEFPELNELGRYCLALARYAQSPVNQFAALGNDLTAVILDPNQRLLPQDRLRLHFERCIGAEVNDSGVDINQAVTSTYLQTMLPYVAGLGPRKAHALVNAINTKLEGTLINRTLLLSRSILPFQVFQNCASFLRIEQDMLLEADEDDVPDVLDSTRIHPEDYDFPRKMAADALNKHEEDLEGEHPSLPCKELMEDADPADKLSTLDLDNYAQMLYERKGEKKRATLLLCKQELIKPYDDLRKQQREPSAAEMLTMFTGETPKTLSEGFVVSVEVMRVQEGNRMAEGHVRCRLDSGIEGIIEAEYTTDNYTPGSVRLRDLVRPQQTLDALVRQIDTDSCTVKLSIRPWDLQEQHRARDQGKTPTDKFYDKTKADKWNEQAAAKAKARVQARRQNRVIDHPNYHNFNYKDAVQFLGGQPRGSVVVRPSSKGDDHLAVTWKVDEGVYQNIDVLELDKESEYSLGRVLRIEGMGSYSDLDELIVNHVKPMVHMVEMMMNHEKYKGADEEDLHRFLTNWSLANPQRSVYAFGLNRDRPGYFNLSFKASRDAAIQTWPVKVLPNAFKLGPADQLADVAALCNAFKTQYTTQASMARGAKTPYGGGRTPAPGMGGATPMGGRTPYGGRNGMAGGATPRGAGMGMGMGMGASAAAGGYGTPLVNMASATPNPYGAPGYGGGRGPPAGGYGGPPPPGRPPAMPGAPPMMPPGMMSGGPPGYPPAYGGAPGGGGEPGPPPSRPQVPRGMHPDRYAQAMYGGPSSGADPSYGGGSGGYGGQQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPS8</accession>
    <name>W3VPS8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPS8"/>
    <dbReference type="HOGENOM" id="CLU_2292895_0_0_1"/>
    <dbReference type="OrthoDB" id="2548314at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="101" mass="11083" checksum="04F02A7549DE1DCC" modified="2014-03-19" version="1">MLRRPPTSVSVQESDVETLKAYRRAKMMQHNPNLSTSSFSSLRPDGSASINDHQPHHHHPSTLQGGQDESDDMDDPGTQPGLSQQENHNPNQPSNATATNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPT1</accession>
    <name>W3VPT1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cutinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPT1"/>
    <dbReference type="SMR" id="W3VPT1"/>
    <dbReference type="HOGENOM" id="CLU_040058_6_1_1"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833168" description="Cutinase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="22997" checksum="5D5DF6BDBE6785B5" modified="2014-03-19" version="1">MQFKSTFAALALAAASLVQAAPLQERAGCSSYVIINTRGTSEPQGPSVGFRTMNTRIRSAVSGGSEYDTVYPAGIDQNSAQGTANIVAQVKAGLARDPNTCFLLEGYSQGAAATCNALPQLTGAAFTAVKGVILIGNPEHKPNLACNVDGNGGKTTFSASGLSAAFTQGVPSNWVSKTLDICIYGDGVCDVSSGFGITPQHLTYGYNTNVQTMGANFGIKALQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPX8</accession>
    <name>W3VPX8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01918</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPX8"/>
    <dbReference type="HOGENOM" id="CLU_033011_0_0_1"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="168"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="441" mass="48784" checksum="2AE483C49D405608" modified="2014-03-19" version="1">MVLTRSRSATPARSIAASFAPSRKASIATRPTPVAKGIKRSATDSDILAVKPTKEDKTKRSRTVAPSSSATAKAASQNARPAKAKAPEEPFVIPQDATEEDCSTRTTVPFPALPFDFEQARAHLCSADRRFERLFQKIPIRCYEEALDGDASDTKDLNLFNTVTTSILGQQISWLAARSVLYKFCRLFHPNEMPEKPDFVGFPRERWPFPTPLMVLRTSDADLRAAGLSFAKIKYVKDLAARFVDGRLDTRQILELDDEEACVTELSKVKGVGRWTSEMILMFAMRKPDILPCADLGVQKGMLNFFLSDARGPKISVKKRKPGEEEDEAQDQSTSSKAASPKEEVVEPTQAKGEEVPLLSQTEVMPKLEAGFSAAQDTSASLDHLIPDEHGLCRQVLQSRAKGNKIKGGQYLSPDEMKALAHEWSPYRSVACMFMWALVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQH6</accession>
    <name>W3VQH6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQH6"/>
    <dbReference type="HOGENOM" id="CLU_276948_0_0_1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1147" mass="123916" checksum="8AC8B189F9E335E5" modified="2014-03-19" version="1">MAVEAPVSASQLAPADGALRDSRKGSAKRRRVSSNGMSTPFHDNSGNATPTRSSPTPTTLESAKKDRKLDRERSDSKDSARARDKDRESRLPACEACRTRKVKCDALLPACTPCQKSGRECFGRDKVPNVSRGLVYELQQKVKDLESRLALASSGATTNGSSSKRGGPPAVDDDDMASDAAETSMASSSRLQPPGPHQHKRGRHGYGRLHMADPSLDSGDESSSTESTSSSDDSPKPSPNDFVQQTSTILETLSSDLTGSTHLPRPASATRPTTQTLDDDEASALTALSKHHKDRRTRSPHRLKRRSSSNASRHREDASSYLSGSLRLREASTSLPFKSRSRTGRFGTISAYERTFFDRLIARYLTYMNTALPLINDVRLHQIATSVYQDDERSRLSAMAATPYDTMPPPPIPPMSASDRVMLSKHRYVVLMALSIALASLSRSHNFSPELRRLGHQYWAEAQALFPVLFRFGDIDKLRATLLQLQYALLVPSAGSVWELSGAAIRLVTELNLHVDRDYDSATNAAFSQETIDLRRRLFWTTYCLDRSLAVALARPPGLSDAWIHVQLPSLCSDADLLQLDRESKTPGQEQLRVDWQKQIFRSHINLRRVQSEILCRLHSVNPRDYSLDNDGVSLTQPAPARPSLALVMEVGPPTPNVEWQTRMMEKLAEWRSEYELIRMPAPATERTAQGDGVASKATPFITRDWIDLNHNLTISLLFRPSPNNPRPDSNGLQQAFMASGRAMKIYKSMHRGSTINFPWLATHHLFISGLTHLNALEKLTRTGIACPSPVVEVVFNVQSCASTLEALTSRNDGYGVKVRDTFDAAASAVLRSVLDPGTRQTAATGAMEGAVQDLEGFMRSSVDSLQGGQARQANRAFLESGGLRRASHHEIMQAAAQQHPTWLSDSTWSSINTIDAAPPPGSTIFVAAPPRTGRFGTPGHSMVPTLSERTTQSMHAPAGPSVGATVGQMQAAGASPRGFGVHAYAAGIAPSAAGFAKNANSDGDLLQTGSAAAGVPFETGARDKEPEAEVGQEERTASTFGFHNWLLQPYEGGADGLQFGYIHNNAFGAPTSGGVFGASNSPSMYAGADPFQYADAGQPAFAAQPKPAAQAETDASTLLDFLSMLPAASPRGAGANGSPAGAASKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQP5</accession>
    <name>W3VQP5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQP5"/>
    <dbReference type="HOGENOM" id="CLU_000572_0_0_1"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="5">
        <location>
            <begin position="488"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="962"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1055"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="969"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1131"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1160"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1178"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136005" checksum="940C66FEE404943F" modified="2014-03-19" version="1">MDDEQNAALHLGGLALGNVLRDLGIDEQHQNDLERLGIASSSGRIKQEDIYNDRFADEDDNLGDAYRHNGSSTKDWETEVDDEMRRELASEHDSEERAALDRYYRQGMAQLEQPRARLRGEDDDFDDDDEDDDAEGEDDDDVPLSQQQPRPDASISHANGHTPQSNGVSRFGDGMIQVKEERDDDTDMAFLSGPVPASFSTSAAPSMPIALPGSDSSRQSSPQTPPLPQQPYMPGAPGHGPYVDMDEVHQLFPDFEPGKVLNFTDLFATRPPKKRRLGPAQAKFHVTPQDELPVPKSTREEMLRPSALRSHHASILPNLTRGLGASATGPETRDSDMDDLQLITTPGVKAESSRVKLAPIELDDWEERVVWATTQNDRPAAAEAADQFHKVDLMDESFDASYAPPSVDKPFNHDLVRGAWTRSIIWDAHTLFEPFDTLVLDMNDPQMMLEEDVGPKIKQNSLLRSDAPVVSAAAKRDLARRQAELDIFNLSNDKFYEQTREHRQRVRQTLGKLVVQHAWPAIKLQLPWYKTKLTKAEARSFHRPAMQFPTNMPLHFSRTISSKKKKEGAGARKAKDPNEMLRTTRDLTLKDTGPYVLYEYSEEYPPLLSKIGMGSLLVNYYRKKDAKDEHVPKMDIGEPYLLDVADESPFMKFGNIERGQVQPTLYNNMIRAPLFRHKPSHTDFLLIRSTTKNEIRYYLREIRNLFVVGQTYPVQPIPGPHARLITNNIKYRLQMIAYKLIQKSQRQRIKIHRLMRYFPDQNELQMRQRLKEFMEYNRKAGDVNQGFWKLKAHIVVPEEAELLKMLPPENICLAESMQVGQRHLLDCGYTNTAEGDDDDESKMDIEQLLAPWITSKNFINATQGKAMLKLHGDGDPTGRGEAFSFIRVSMKEIFLRAGEDAEERLAQAEAEAKSKSGHKYSVAEQQAVYRSEIDRIWNAQCRSLSNPVPAKLTAEDERRAALQANGGKPEQRGGGRGESVRRDRSPSAMSTVNGDAGDKSTKVLRIRRLVNGKWQREMVRDPAVINAYLTQRKKIEDEAIATEDLLPTGDAAIDMARMKRLQEELAQRKKNQERRIQRKNAKAAAEGLAIPGGYKSLLNKTDTKRRCGRCGEVGHMSTNTSCPMFPKDGGKNGAGGAAGGPGTPGTPGGAGRPGMPHLASGGGFFGPGMGMGIGIGSAGPMTPMTPAAQTPGESPGPSQSPAPGTGTPTPAGLKLKLKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQW8</accession>
    <name>W3VQW8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQW8"/>
    <dbReference type="HOGENOM" id="CLU_013161_0_0_1"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="434"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="773"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="833" mass="89664" checksum="E5B6BD1941E8D796" modified="2014-03-19" version="1">MPALSGSAKKVSVYGRKAEVRVVNRHSTFTSLENDENDPFGFFKAQPKPKLTYGRSRASTFPADILEDSPAKDAASSDDSLDEAASMDKSAQYDTANSSVSFHSAHSCSFALPPLKANKALKPKPTVLTATTLNFTSPQKASKKKSTNRSNKAAAARAEPGETVISTPKARTAPAKRTARESPATLRALTQPPAKSSNALPTASTPPSNLSNGRAPRRAAQAARVAIEDYDFTDRDMTPRRPVPTKSYFAEKARQLAELASEEQQEKQRVKDASSVKAKSRKSMATRPRQTTVSRAALPSSIANSSSSDASSTQTSFSLVIPSIDEMPEQELSTTLLTKAKAKRKQNKHVTRRIADLSDDEAEACAAGSDDDDEADVAASLVAQISGLTVTDQQGAPEQDAYLGALLAAVSQTAPEPFAKTIQQLRSTPSTKGRRRLEKIGEASYSEVFKIFPAARSATTDSGAHEALVIKIIPVANPASVGGASDDELPYTSAAADVEREVRLMQLIGREAASAGAFVSLQAAHVVKGGYPAPLLQAWDRWDAKRRAKTGEGAENIRPDALGGSHAYAVLVMTDGGVDLESLRVKSWVQAASIFWQVSAGLAEMEARYKFEHRDLHWGNILVQSVSTSDAPATTSASEWLLDPHGSGVKATIIDFTLSRATTATSKARKSKAEVLFYPFDDETLFEGSGDTQFDVYREMRLATLGQWHTHCPATNMLWLRYLAHKLVDAKCKSCKTPAQPDGGDAAAMREWRAHKALVSATEQLDRAAQDVLASHEAPRATGRRKSLHPRATMAAPRKGRATTRVTPLTKETNETTPTVRSATQLMHALALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQW9</accession>
    <name>W3VQW9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQW9"/>
    <dbReference type="HOGENOM" id="CLU_018398_6_0_1"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000077">
        <property type="entry name" value="HemK methyltransferase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="7">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="226" mass="23811" checksum="BED93EB43A6A3CB9" modified="2014-03-19" version="1">MIPTPSLAHLIKSDLRRVYEPAEDSFALLDALEADADVLRSSLGTSGPLCVEIGSGSGVITAFIAQILGPAAAAYVAVDVNDHANRCTVATGKHNGVHIEAVRASLLSALQPRAGGKIDMLLFNPPYVPTEEEEEQMAQHDKDIAGAWAGGATGTKLVDALIDDGVIADVLAPNGRFYLVAIKQNDPEGIVSRLNSQALQAEVVLKRRAGGEHLHIIRAIKPGSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQY0</accession>
    <name>W3VQY0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbon source-regulated protein (Putative arabinase)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQY0"/>
    <dbReference type="HOGENOM" id="CLU_010779_0_1_1"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF8">
        <property type="entry name" value="ARABINOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833184" description="Carbon source-regulated protein (Putative arabinase)" evidence="1">
        <location>
            <begin position="24"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36440" checksum="50C85FA506A1D057" modified="2014-03-19" version="1">MRSFPSVLSAVILAISGARLVQGLPAPETSATALQERADGAAGFLSATFLGDVPHVFLHYSKADAPVTFSAVSGSKGELIPTLGTGGARDPYIFQNQVNGKFYILATDLDIGKTNWGDAQSHGSRSIHVWESSDGVNWSTERLVELMGPTAGYVWAPSATWDPAANAYAVFWSSQTYAGSDADHTGAAEGPFVYYSHTTDLINFTTPQRWESANFGNKVIDQEVADLGNGNLVRWYSDVSGGTGVVMDKTSEGLFGTWERIGKPVDVVWEGPAIQRDIVNPSKFYLWEDNYGGPGYSCFQTTDLYTIPYAACDPALSPSGMRHGAVVQVDQSVLSGLESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQY1</accession>
    <name>W3VQY1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQY1"/>
    <dbReference type="HOGENOM" id="CLU_1396889_0_0_1"/>
    <dbReference type="OrthoDB" id="10491632at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="195" mass="21183" checksum="8C770F7633A16CBD" modified="2014-03-19" version="1">MQWRGRCQTAIPSGTAEAPLDREELRIKSHMGRFSHPLRSFPASPGEPGRGLAPEQVSLTDADYGLRGGEPEGYSSAEFGSIPASAHRRVSLPGSVSLRYAKSIQAKRAQDDRLCRPGTKAHLDPDPSVQSVGCTDQTARQGRAATAAARLSDGVTLSLRLEHHNAVHMFSAEIFETSPWARLMDSTDVPESHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQZ7</accession>
    <name>W3VQZ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="17">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_02214</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="17"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQZ7"/>
    <dbReference type="HOGENOM" id="CLU_003827_9_0_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 17" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="82"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS63890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="325" mass="36302" checksum="2311A1BEB85BAA0D" modified="2014-03-19" version="1">MVLVEQVVLVSSILVTFGVCLAATKFTAKYVFPDFEPLQFYDAATNPMEINVVVAFIVGLVLSVGALLYFDSQKLKPVLNPTQWQQYRLMEKQTLSPNTALYRFKLPRQNNILGLPIGQHISIQANINGKNVMRSYTPTSSDDDHGFFDLVVKSYEQGNISKYIGSMKIGDLISVKGPKGQMQYTPGLSRHLGMIAGGTGLTPCLQIIRAVLKNPSDKTQIDFIYANVKEEDILLKQELDELAAKHKDQFRMHYFLNEAPAGWKGGVGFVTKEAIEKNMPKPADDIKILMCGPPPMINAMKKHLDELGYEAPRTVSKLHDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRD8</accession>
    <name>W3VRD8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRD8"/>
    <dbReference type="HOGENOM" id="CLU_903519_0_0_1"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000001">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="153"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="321" mass="35009" checksum="94C7C0A558067D5B" modified="2014-03-19" version="1">MSAASFVQRAGSMLPALRSVASTSRARMISTAVLRQPLAMPLARPAACASGLDMQRRYKSKRSSAQYIDPHAAEDDDVPVMKTKGKGGKANRGGQSRSKRGDDDAPSDAEYKTSTRNQDLPDEAFDFGTITQNMTRAVERCRTTASTLVGSFGRADPALLDNVKVEYPGTGSSSRSLHPLREFATVGVRDGALIVTAFDADMVKHIERAIYAADLGLTPQTQAHTNPGDENVLRVAVPQPTTESRQAMVKDLTRICEHARVSIRDARHRALKQIKSDIDRKVVGKNEGDKETKKLEAETKKISAQVDQLFEKMKQSLLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRH0</accession>
    <name>W3VRH0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRH0"/>
    <dbReference type="HOGENOM" id="CLU_026936_2_1_1"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="26"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="526" mass="58701" checksum="7548229305F000A8" modified="2014-03-19" version="1">MVKRRRKTRTHLKGPNNSAASSTNAPKSFIIRTGKVPRAVSALVQDTRKVMEPNTATRLRERNSNKLKDYISMAGPIGVTHLLIFGQTDAGTNLRILRAPRGPTLTFRVNKYALAKDVQASSRRPTPPGSEFVTPPLLVLNNFGGEERQIKLLVATFQNLFPPIQVQSMKLSQARRIVLLNYNAATGTIDWRHYLISVRPVGVSKSVRRVVEGSRSASRTGTKRGRLPDLSSTQDISDYVLGRTNGSGSVNGEFETDASEAESEAEDIADPRNKVHLHDRYVGRGNAANTQKAVRLREIGPRMELKLVKIEEGCNEGAVLFHEYIKKSAQELTQQHRDHVEKKKLQEQRRLEQEQNVERKKAEKAELRKTSRRNAGLASESEAEDEAADDEADESDDQDEFAYEDQFGDAEAMDKDEELFDDDQESDSDGEQDEAEEEESDDDDGGVAWNPKRSESGYDNPPGIEPHSDESDLEPIPVGGMQHDYGSADEWPEYSDEEEEEQAPKPKKSAPVKAAKRPSAGKKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRR3</accession>
    <name>W3VRR3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRR3"/>
    <dbReference type="HOGENOM" id="CLU_729826_0_0_1"/>
    <dbReference type="OrthoDB" id="2554557at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="379" mass="40139" checksum="124B498E50C44CCB" modified="2014-03-19" version="1">MTSIFASKSLGRRRGSAQTGELSDSSASSRNHSISSRDRSTSLASSQMDDWTDGFTGIVDLDRQMRQLAMAEQGHASLCGSSDLDVYEPYSPSSWLGEHEQRRRKSSSDARLASGSQSSLSTRSIPPSPLSPAHTTASTSTAATSRFSNDSRTHSSLLAKRQSSGAVDSFDGAHSPLRLAPLPASPSAFGNYRLTDSAPLRSSGVFDSPIWSGSEEQDPLTPLAVSARQLAPVTPGTAAAATWTDPTAPGYFPAGLAARSKKSRSLRKKTARAPLPRLVSGEVVSSPTAESECALEEAGAPVRGEDEGVTGLGFVLPSSQPHAPSGTHAIRRSAQSLALSLRFKMLRAKRRVRRTGLEAAELFTPQSSRRSSLDTSRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRR5</accession>
    <name>W3VRR5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRR5"/>
    <dbReference type="HOGENOM" id="CLU_103874_1_0_1"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="175" mass="19022" checksum="DD649BD953562834" modified="2014-03-19" version="1">MSAGDKQHSTVRAALLDDEGDLSLEFEAALVRIFARFSSSYQKRFPDARASGSNASATLARPDAADVWTEAELDAFSTVTNGGALPQESKDEIREFLDTDEEGNLTFSGFCQMYHLQSDNDADETWKDLAQLGFDDSLQYKHQDAQQAESAAPRDEGALASSSQADKQSGEKGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS51</accession>
    <name>W3VS51_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS51"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="514" mass="56530" checksum="9E1CCDDDE64DC213" modified="2014-03-19" version="1">MPISKSPSMEAADDAKLDAYVGEVSSTPYVSSADGENAKAQALDIDASTITPAELKQVLRKIDLVIMPLLCVAVLLQFLDKTSLNYASLLGLKKDTNLKGQEYSWLGSFFYVGYLVATPIHGFFLQKMRLPRYVAICIVLWAISLGAHAACKNYGQLLAARFFLGVFEGSLTTANILLTGRFYTQQEQVTRTSIWFANNGWAQILGGGISYALQVQKPSKLKVWQQMYLILAGVALAFGIVVWFFMPDSPATIRYLNERERQVAVHRIKQNKSGIHDSKWKWDQLKEAVLDPRLYLFFLVVFTANVANGGVSNFGSEIIKQFGYNSKTTALLGMAPGALEVVAVYFGAWLAFATGTRVIPGVLMYMLAVVGGTMMIAIPAHAKAARFTGYVIVYCYPVASPFFYSWLSSSVSGTSKRIVFNTVLQVGYSVGNLVGPQTYRAKDAPDYVPAKITLIAMFGAAAVCLTAIGSVHYLWNKQNGLLAKPTEAEAGARDDHEDLTDLTDKQRTSFRYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS83</accession>
    <name>W3VS83_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS83"/>
    <dbReference type="ESTHER" id="psea3-m9lyb4">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_8_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="193"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="733" mass="78822" checksum="BEBFF5095DD29AB6" modified="2014-03-19" version="1">MKTFSSVGGLIGALAIGSQVVGAIPFFSERNNAPSDGAAPNQAQLGPVHILYQNDLSTNASTGALLLPNSVGADSAAQVCEQIGEKLFPLDTSLQGGIGSDLIDQFNYLRYAGTIGWYDTFWTSNGANVAAYKASRGSVRPYGQGEKLGVLCTHSAEPATVPRANPYANGSPTDKHITVQSGDYTVTGYRDRRSFRFLGIPFGDAPVGSKRFMHSTPYTGNKVLDATSYRNACVQSTTPLGPMPVGEDCLNLNIYTPTLGSYDRKSLKPVLVSIYGGAFVSGRNSLHSYDGGNLASRSDIVVVTLNYRLGALGFLASGKDLPGNAGISDQILALKWVRDHIAAFGGDPNRITIGGESAGAQSISALIASSEAKGLFHGAFMLSNPWVPWVNRSAQSKYITPAVAASLNCPVSGHAMVECLQKVSDPAQFVQGAAFTNATNAITVALSKVGGSSLFGASIEPFLPTPDGILDGQFFYLAGNGTIPNNVPVLLGTTSGEGSLFVYQLLNQTLPNMQPALDKAFSALYSPDFVAKLDASGYFKLDERIGDSVREQVAKAFTYNFFTCPTQRIMDLAQQKGQFPKVYLYETQSGYPDTVGYPEKCAPEGTGLEVCHSDDIKSVWGSLNYEGIQVSQQYLDFVAYNADAFSAFVRHASPNPKQEYLRARGRGYTYTQKVQNYNKWQAFYEPLLESENFNTQYLSAPNGIRNGAIPHKDVCDFFYQNGKLTYQTLNNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSA5</accession>
    <name>W3VSA5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSA5"/>
    <dbReference type="HOGENOM" id="CLU_014338_0_0_1"/>
    <dbReference type="OrthoDB" id="3361294at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="610"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="112"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="845"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="873"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="888" mass="94884" checksum="3893A4EA253B5BBC" modified="2014-03-19" version="1">MVPTSASPAGDTAPAPKAPSYDHLPDLSADDSIDGTEKGRPTFEQLNATLISRGYLRSALNVAGMHQDSVGVLADALHAMISQREEDIEVRTALTAKNRMLAASLERAKRFHKEESERAADFERKSEAAKAKLTHVSAQLEAEQNAHKATKDALARMRRDLQAIKASALQYKAANDRSVARVRARIGEVTSSAIRSAVPDFQIVASAFDDLPTSSSTRGSAASAYAQQVQELEQKRTSLVEYNQALKRLATDAINAARRADQELLDMVEAEQEDAKKRDAESAPRSAGTRSTSSGSLSSHGASSRKASTSDAWLEGHRPLFQRDLFPATDSLRSTSSGMLVSASSSKALHPALRALELTSTAISTHVQSLLDLRTERNIHQATANQRFAAELKEQAWVAQLEHGIHEDLRNDARLSLNKANGPVHVGSLASAAAAASSGTSAGGTSQRIDWQREKSELEKKLAQLVKQLAVAEQNAARKDKEVRKLAEAEQRARNLLDQAAQPSSPEDTAQATQSAEIMKRADALRIELQAAEQARVQLAQRCNVLEAEAQELRNERDRVLADPAAPSFERGCPEKIGPLTSLKRLADGEVAEIHARDAKRRSELGSLSVVAEDAETAPASDTVSAADAASEEATSDGDGQKGTDDASGALSFGESLSNNPELGAIFGGNKWTEPSKSKPRAAPRRSSRLSGGGTTDGSSAPAAVEYEKTSERVEGRKRKADREEQANESSSTGRRTSSRVSTGSSDSKEASPRSSKRPRPEADDAAIAQPRLSKPAVVEAAAEPSRRRMSTREKQELDEQRRSRAVSSLNGNKTPALTSRRVVSASSSSVTRPTAASLRRSEGVQGSSVKRPLSNATNTREAAAPITTAGKAPARAVLSSSSARARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSB3</accession>
    <name>W3VSB3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCNGP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSB3"/>
    <dbReference type="HOGENOM" id="CLU_781028_0_0_1"/>
    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="38690" checksum="FA6DADFA27CFA87F" modified="2014-03-19" version="1">MCGSSPSARHPSREGILQIKTLICLADCNQPSYTGTFGRSGVQVSKKGADEPLTMAEGPGKAVNGSSAAVIGQEAPATKDDKAAEYLDTFARYSDLPPSSAPLGCFRGTQERIIDCFAPHMLAEVSDPETLQALPYLLPPPQHPSDSSAASLSSSRALWGQSLESRTFLPPSPDDEVIPVDPDIAAKLERFLELKRQGMHFNKSLMETHAFKNPHLYSGLVSMLSIDEAASNLPFLDTARSEPGWRRLFPFSEEMLIEGDPIAASNTQSQEAFAAREAKINAKGKRTIDFVSSSTSASDESRKTAQADKQARLDESAHGRSKRGRSSSSHHSTSDRHRRSREYAEARPKDHSKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSC1</accession>
    <name>W3VSC1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSC1"/>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="262" mass="29525" checksum="5E06FA61279437AD" modified="2014-03-19" version="1">MSWGGFKKSINRAGTTLMQKTGQVERTVDSEFNSTEEQYRTLEREVTSLQKEAKAYLDAIRSLASSQSRIAEAVDGFYTDSSDAAMSANAYRRAVDELDTKTAKEIDAPYRATVLEPIGKLASYFPEVNKVVEKRNKKLLDYDAARSKHRKLVDKPSDDPTKLPKAEKELEDTRVIFETLDDQVKGELPQLVDLRIPYLDPSFEAMVRMQAKFAEDGYEKLGGVQRFFADGVREEYADGQLDAQVEAVLQEMRELSICGIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSC8</accession>
    <name>W3VSC8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253850_0_0_1"/>
    <dbReference type="OrthoDB" id="3366885at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="311"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1371" mass="152014" checksum="E32133D51EEA3A16" modified="2014-03-19" version="1">MPPEPIALDSSDEDERRYPLRSDRRKPKREYESDSEVDELESDKDDDPQPCAAPPTRKSPVRSAKPKSARKLKKERNQAKKKKKKLQREAREAREAREARQENSAVAAESAHCPTPRPGDGDDIDEDDDEHLHGLIVPSKDARRKSPVERVTEATSEDEVELIASEPPRPESASVPPERSSAPITADEDTDKRPPNSAASAPPTLAVPRADSAPAPGDESNPVAIDTSSPPMAADDEAVDDVPDDASVSDISSVTYSDSEEYVEGEDFYTSSEGSLHGSDSEEGLGSWTKRDQDKWQGSTAHLDAAYDDVYEVRAVLRHRRNPRRGFMQYRTVWAGYPIYSTTWEPESHFNSRRTLDEYWQRQGGRPADAPYDPANHSTHDSDTDRAVMRRPRRRAHEALKKKRREIRRDKVDLRKYMASLDHERAEKKAKAERKFELWRREKRVELETERTREKGTSRSHQKRLEKLNKKRWKRAGGADGAGAAASARFSATHANRIMADISMKARAGPSVSARTRVSQLDDSIAENDDNQLVFRKSAPGSGPNYPGLAASMSGSNRPRPGSTSARPIAGPSSVSRPAAASGSASGSNSQAPPPRPPPGSYKGQHHRGPRVQIKEDMHSFLNKLHSDVARSRAAQDGNSQAVPAPTDSDGRPITMKRRPSEAKRSNLLVLQPVKDFQGGSRPAAPASVAHVSHSTSSEAGDDGDKEPFDIPEMSAVRGQFNPHQPAPDSDEERKRAAVPKRDSLAPPVPQQKGKQTEDPRRRLKAPSAPKRDQHASWSPPGDDAGWNPSGWDMDPGPAFSPRALTPRSPLEGEFHHHGHGAPRAPAPQSVLAHCWFQIVTDGTFGLEGTLCSHEPFPSDRAQALGLADRVTIQFDRVMPFACIREVLAGPDIAWHEAMVLGAQGPGAIRDRAHLDQLSERLKVTDMALLSAVPSPRASVNAEGSAQQQEYLVAFSSKYSMDPVAGVPHALQNISGHSATLCVMPLRLSLVSAPSQLLAFRRQPPLDSTIASIFDTAVGKRSIEDMKIGRSEVRKVKRAAQRYGIVPALYEGIRSRFNVLFLGHNPPAYEKRMFYYLIRIFEGGVRLKVDEEKDAKLYKDPKIGVNVFVRNAALKEILSTDQEQELVLAAYLRRFKRVQRCQFWTFGFSPEDPDERIRELFPGHSGLVSFSMSAILADLVRSCTEEKRSQDSEEGQLTQQTEKGLQESILCNTQDHLPSQWRVRLHPWIRPCFRLLADHLEPVCRALNLVGEDDEFPIELFLELDTKLEAVYTAAWVEEWSSDAIHGLPFEEPSELPDEPEALIKQIDEEVFATLRDSQLASIRDTRFHVMVSGSQAADERDETELAGVEVVSLADFGKNACSKLAAFPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSJ4</accession>
    <name>W3VSJ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSJ4"/>
    <dbReference type="HOGENOM" id="CLU_089876_12_0_1"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="64"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="160" mass="17081" checksum="DD1D6AB54369BF4C" modified="2014-03-19" version="1">MTATTGSAAEGAVTLAMINELQQQVLDNNPIYKYLLSDLEIKIVSPGFIEAHVPVSKTLMNSKNILHGSTSATIIDWIGGIVIASTSPDRFKNRGVSVDIHATYVGAAKEGDLLIIRGKSNKVGRNLAFIDVQILGRKPGATDDTDDRVVCSGTHTKYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSK7</accession>
    <name>W3VSK7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSK7"/>
    <dbReference type="HOGENOM" id="CLU_037460_0_1_1"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="442" mass="49271" checksum="C7AE8464418AB593" modified="2014-03-19" version="1">MPFAQLVIGPPGSGKTTYCFGQYQFLSLLSRPCSVINLDPANDRLPYPCAVDINRLISVRDVMAELSLGPNAAMLYCIEYLEKNVDWLIQELKRVMDEQRQGKTGQIAGHGDQKTPVGPVSPGFEYLVFDLPGQVELSTNHPALKRILATLEKELGLRFVAVHLTDATHITDASRYVSILILALRAMLTLELPHVNVLSKVDLLGQSFISRSKRSLDRYGPDSDTDADDDEDMEDASADRSGNPAEMGLQSDLAFNLDFYTQVQDLSYLRDLLSQPSGPGSSLRNEKFGKLNEAICELVEDFGLVSFETLAVEDRRSMFRLLQVLDKAVGYIYVSASSNAYDYGDEENEGAYEPGRASATAGAALRGQMGADAHSLFSVADRGDPLGWGDALEVQERYIDHRELYEEAEAEERKQMHEKEWEQKVWSEVRKATEEQKQKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSN3</accession>
    <name>W3VSN3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSN3"/>
    <dbReference type="HOGENOM" id="CLU_1807032_0_0_1"/>
    <dbReference type="OrthoDB" id="2555955at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005590">
        <property type="entry name" value="DUF333"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38008:SF2">
        <property type="entry name" value="HEMOLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38008">
        <property type="entry name" value="HEMOLYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03891">
        <property type="entry name" value="DUF333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="143" mass="15976" checksum="64D13BD7260D1AAB" modified="2014-03-19" version="1">MPNRIPSLRIACITVLALLTLWYLWSPSTMQIANPASEYCIQQGGTLEIVKDKDGNEVGMCKLPDGTVVEEWDFFRSQQQPPKVGLANPASVYCIQQGGTLEIVKDKDGNETGMCRFPDGTVREEWDFFRSSQDQDEANSAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSY2</accession>
    <name>W3VSY2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSY2"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="529" mass="56551" checksum="A797ECC69458B053" modified="2014-03-19" version="1">MEVSTLPIEGRAPPSPGSDDMVHKDEHELTPTQSASTPLVKPRANNSVLLILAAGCALLSDGYQNSLMTMANVVFRTRFGSKVYTSAVATRISNASLVGAIIGQISVGIICDRVGRKAGVTITTILLVTGAIFATAAYPVGGNPQNMFWWLTVARGAVGCGVGGEYPASSTAASEAANERLGKKHRSQVFILVTNLVLAFGNIVSLSVFMIVLSATGYHNTTDAAGFHKLGIIWRVTFGFGALFPLIIFYFRMLVMNASLYRKTAMRKKVPYMLALKRYWPRLLGTAGVWFIYDFVVFPLNVFSGSIIASILKTPTLLKTAQYQMLLSSIAIPGVFVGVVLLPRLGSRKTFMLGFGGFLVLGLIIGCAYDRVMSSTVAAVILLGLISSSGNAGPGNLCGLVSSESYPSALRGSAYGVSAAIGKTGAAIGTQVFSPIQIHAGKRWVFIISAILGLIGIALVYFFIPETTRFDLADEDRAWLQYLVDNGWDGDIGDGSEGVVNAKQALERVREAEYKPKNNDDEESVGSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT41</accession>
    <name>W3VT41_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02317</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT41"/>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="124"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="890"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1049"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1161" mass="131777" checksum="3933D1284BB68CCC" modified="2014-03-19" version="1">MAPEKRTSSGRRDTLLDEDDDVDAISPKRMRTNARDSTANDTTPRRSYVRGSARPVPLANASDSDGVVTPDEDEADAQQEQDEHDEDEDEDDDEQDEIDSDEDRAEEERRQAEADRGYAQSGIVEKIELRNFMCHANFSIELSPTLNFIMGRNGSGKSTILTALMIALGGKTSSTNRGSSLKDLVKKGESSATITVTVRNQGSDAFRPEAYGDHIVIERRILADGPATWKMKAANGRVVATTKSELESFCDFANIQPDNPIHILTQDTARQFLGSSDPSEVYKFFLEGTQLSQLVREYTLIENHISGMRSALALKSGALEQLEALAQQALQQWQKVRETRGYQDKIDALDREFVWVQVHDAHAQLEHAVLKTERIRTKLVACDKSLNECLDALKQCEERIVRLEGESNNFDDDFTPLQQEYEGLVRKQKDISNQIKAFNVQERELNDNISELNKGIERYEDQIREETAKLADEGKARREQLEQERQALQTQRQTLQDEVVEKDEQLRELDAKREDAARREQEETDRLQRLKNEYQRNSSGLTQLRDSARNRLVAYGGSKVPVLLQAINNEPGWRSKPIGPLGTHVKLKDMRWQRVLESVIGNTLNSFFVSNHQDRQRLKKIMDRVGCHSPIIIGADTLFDYSSGEPHADILTILRVIECDNEIVKRQLILSVHVERAALVDKRADGDRLMRTQPYNVQACFSADMFSISGGQAGSLSAALPEHRGAPRLSQNVADAIRNLEAEQQRLDQEIAQCQQALRDLRQEKTAAERQKDVCRRELGEMRRRKDMLRQENVRLDEQMQEAAPGNISALEDAKREMETQKEVIMQQFEEIQTQKAEVVAQRAPVQAEIQAIDERKRQFEEQMSSLQGRLETAVAERVKQTNNRDYWKRKRSSIQEDVAASEQEEATLEEDHRSLEEKAKEYCDEVETRRTMAEIEAEKKQLQLLKKKAASEAGVSLEQAAEELQKRKRALSEAQEEVASMNEAERRLRHSLEVRYAKWSFFRRSIAVRAKSNFAKNLSMRGYEGTLKFNHKAEKLSLVVITQDAASRSGAATPTQPQAPQHSNKGMSGGERSFATACLLLSLWQAMSSPIRCLDEFDIFMDQVNRRVALNMILNEAKATPHVQYIMITPQDMPDMKAEMDGVRMLVVNPPERGQGALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT90</accession>
    <name>W3VT90_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT90"/>
    <dbReference type="HOGENOM" id="CLU_1662124_0_0_1"/>
    <dbReference type="OrthoDB" id="3335062at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="157" mass="16799" checksum="BD5AC1C105ADC803" modified="2014-03-19" version="1">MAEHVALYVLSGSSSSGSAVLENIRASDFIDEINSGEGPREECGLYSLIQLVQPADSVTLKDEKDVLDFHAKLVKGEAKASVDGAEATWNASCLLIADKDQDDQVLILELEDGKVGQRLKAKAKSSVEVASNVSISNMSLDEYKDMCGNAEIYDAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTB6</accession>
    <name>W3VTB6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTB6"/>
    <dbReference type="HOGENOM" id="CLU_019845_0_1_1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="347"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="785" mass="82854" checksum="36C7F0269867E943" modified="2014-03-19" version="1">MAQPIRLKKPAAAVAATLNSAASSSSASISGPSSHASESHTQNVVVLGGSYGGMHAATVLAQKLPPSHRVILIERNSHFNHLYVFPRFSVLPGHEHKAFIPYTSIFKDAPARPQAHIKRGRSSTPSSSKLNKPSVTTASRPNNNTRSALEMGSTSSADTKPGPSRKSAAGLASTSSSMPNVPENAQVDGATSPASDDYLDSARADSPISSRARSQDSRHSSQFSVSTDSSAADSDSISSSYDIASTAASSYIETDIKVAGPSGFASELSNNAAKARQEEQLGRPEIQVTELTDAVQDGLDLDGTNDAESDDDVAQGFENSAPHIVLQATVTDISPTHVTVTPTASSSAHHLSQFAKKKSLWSIDSVQIPYSHLVYALGSHLPDPLRTEARFKADGTHWMREIQQRVKASDEIVLVGGGALGVQFATDIASVHPGKNVTLIHSRKQLLPNFDERVHDIAYHRLQQLGVNVVLGERLALTEGCPRGSTVQASAASAGTAAAAPAAPVSQKHEVCVAGDAKGEGVQAHAEGMCIGSGRKLVRTTGGKSFECDLLLLCTGQQPNSSLMAKLSPSSVDPGSRLVRVHRTLQVAVPDPRDAAQQPFDAKPPCGDCDCFLDKKAHGAELASDEQGHLEHHLGGHVSGKLPNVYAIGDVADAFGALNAGYQAWNMADVATDNILRDINAKNGTSGDAQMVDFQPAVNMLKLSLGLGKMVFQGSVMADDTPEEQINPSDTGDLDDMPNNKIDRLDVNGRIPGRPEITIKHDPNDLGVEGVWSFMANADPSDMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTC0</accession>
    <name>W3VTC0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTC0"/>
    <dbReference type="HOGENOM" id="CLU_002220_2_0_1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="652"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1140" mass="122462" checksum="6CEEF7FA47E9FC4A" modified="2014-03-19" version="1">MPFRLHTPPALALGVFDREELQVLINCAAAAQGPARPYFDRRRTSLSSPKLSERPPLDLTCKMGSISADRPPYLTLTISQALSLEPPPAPEPRQHASVNAMLDARAEHMPHQLAVGFTSLRDKDWHCESLTYAQVRALAIKTAHNLQASLPPRRANSKSPNGTPLVAVLAPSGLDLFAHIVALWRLGYGVLCIAPGSPAEAVANLLRLTETTVVLAHALQLAPARAAIDTLEDERAHVVEMLRTSTNNIEKEDESSWEPPTGEDVLVTMHTSGSSGLPKPIYQLNRFWTASMLTAPGRELCAFTTTPLFHGGMSDLLRSIQAGSTIFFHPTADPGALSTTAICRAIGACPQRPAYFLSVPYILDMMFTDAAGEGAEALVGMQLVSTGGAPLPQQLGDQMVAAGIRLVSRLGSSECGFLMSSWRDFASDSEWNSLRIPDALGQKMLRFEPQDPSASGGLHELIVNAEWPTKLVANREDGGYATSDLYAPHDSLPNAWRYDSRSDDTLVLVSGKKATAPVGETRLKAVSFVSEAIVFGANRAILGALVFVTPQAAGEGAFDDAAQIALLRQLQPVLAQINAASPPHAQLALEMVKLLPPSEAASIPRASKGSLQRGRAYVRFAALIDQVYADFEEGRSLRVPPAGQTVGGKEALEGEELVAWLVDTVERINGTRLAPDADVFVAGVDSIQSARIRAAVHQNVELGGKVLGRNAVYEHPTLVLLAQHISDVRNGNDGDAHTRQSRELGLMHQLVAKYSRPKPASPQQEEGGVGTLFILTGVTGGLGAQLLDRVLSRCSGEDHVVCLVRASSDATARDRVLASLDSRFLSKARGAVETDRVECLAADLSRRDCGLGKGLGWHSARVVTIHAAWSVNFVAGLSSFEADNIAGVAHLLDLHDSLPCAAAADSAFVFCSSVASILANRSEDVGLEEKASRAAGDAVAMGYARSKWVAEQIIARHMGTGGQYAAVRIGQLCSDTAHGVWNQSEAWPILIQISQAVGCFPALNERLDWIPTDVAAQTVLDIALSTSDKVYNVAQPTTAAQHDAAGWNELYKWLAEDLHLELVQPLAWLEAVRRSDCDSRGLLALWERNFARSPDADAPRFVCDKALALSSALRAWGQHGVDAPLIHKTVQHWRSIGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTH4</accession>
    <name>W3VTH4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTH4"/>
    <dbReference type="HOGENOM" id="CLU_053567_0_0_1"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="336" mass="37631" checksum="D686A8B649B91A12" modified="2014-03-19" version="1">MRQRRAKIYRKMLQQYSLQFGFREPYQLLVDDTFALALARYKISDPLNQFGNVLQTKKVKPLITQCCMAALYALGKEHQPTVEMAKAWERRMCNHREAIAPTECIKQCIGPENKHRYIVASEQAELRRDLRLNVPALPLMHFTQAVIVLEPMSPLTRNRIDDKEEDKLNLPASEAGLLKSKPDVDVDIVGAEATEEGKEEKEGGARRRKRKAPNPLSVRKAKNPKLTMEQKLQREQELKKQKQRAAARARLQATNPEAAKLADEKSPARRKRKRTARPASTAVTSTAADAEAAPTSKPTSATDAGTEPAAKKRRPRTKRSPTTAPTQPTASAPASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTQ0</accession>
    <name>W3VTQ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTQ0"/>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="104"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="645" mass="69846" checksum="0DB887A453197F61" modified="2014-03-19" version="1">MTASSWPGVSALGEQLQHHIQLFVLQTDLYLFHLFPALRSGAVRSPTGLIFTGLIILLVSRVGSYLTAYLAEQGASVSIRAPPQAQPGWSSTVLEKPHIRDAAKPGKIICYDPATAYLIGEVDADTRETIAQKIARAKQAQVAWASSSFAVRRKLMRTMQRWVVRDAETITRVAARDTGKTAIDAAFGELLTTCSKLAWTIGNGERVLQTETRPNNLLLMHKVCEVRHEPMGVVGACVSWNYSAHNVLGPIIASLFAGNAIVVKASELVAWSAHYFVDAVRECLRASGCDPELVQLVTCFPEEAEALTQSADIAHLTFIGSEHVGRLVAQAATKELTPVTLELGGKDPAILLRDADLKYFGSTFMRSCFQGAGQNCIGIERFVVDEAIVDRLVAIVEPRIRDLKLGSFMDDAPFGASSRGGQKGERVDMGAMITDARFAHLEQLIQDAVRQGAKLLVGGKRFEHPKWKQGHYFTPTLLVGVTTSMAIANEELFAPVFVVMPFKSGDLDAAIGIANSTRYALGSSVFSATRAHCDYIAARIHAGMVNINDFGVSYLNQGLPFGGVKKSGYGRFAGPEGLLALTQPKAVTRDRLFSLLKTGIPPPLDYPMHKPARSWGFVNALVGFAYAPSIPARAKAILDLILNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTU8</accession>
    <name>W3VTU8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_01450</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTU8"/>
    <dbReference type="HOGENOM" id="CLU_002333_5_0_1"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="16">
        <location>
            <begin position="91"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="17">
        <location>
            <begin position="530"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS64211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112144" checksum="7386612F0DDD5A38" modified="2014-03-19" version="1">MVEISIQKRPLSGVELESAQRKFFRKTARGKVLKVLRERYLRDDIACGSRACQRCHHLHADMQKQAQDAGLQKKIFLDPAGLKNNKVDRNHYLVLDTNAFLHQMDLIENPSFTDVIVLQTVADEVRHRSLPLFNRLKNLIADPDRRFWVFYNDFGRDTAVLQHQDESPNDRNDRAIRVAAKWYRNHLMASTGPGSSTKANLDVLLISDDQDNVQRALNDDIRAMSVRDYIDGLDNADQLLDLLASRSVVAGSGGSDKRAVLYPEHLPQNQLMAGIKSGQLLQGFFNANPYNYLEATVRAGTLTRPILLVGRQAMNRAVDGDIVAVQMLPKDQWKAATEEVIDADAALKDDDAEAGDGEGVADDDIEARLARKEAADAEANARSARGEPQPTGKVVGIVRRNWRSYVAHVDANSVNSSALSSLGAQTVFATPVDRKLPRIRIRTRQARELMGQKILVALDAWRPVSRYPDGHFVRALGQAESKEAEQESLLLEHDVPYRPFSKAILDCLPAEGDSWVVPPKDMTHRAWRDRVDMRDEIICSIDPPGCQDIDDALHAKQLPNGNIQAGVHIADVSYFVRPDNPMDAEAASRGTTVYLVDKRIDMLPHLLGTNLCSLRPYVERLAFSAVWEMTPEAEIVSVRFHKSVIASKAAFTYEEAQLRKDDASKNDAITKSIRLLNSLAKKLKQKRMDAGALNLASPEVRIHLDSSESAGPIDVEQKEMRETNSLVEEFMLLANVSVAERIYEVFPMTAVLRRHMPPPRTNFETLQDILLKRRGMELDVSSSGALAASLDKCVDPADGTFNTLVRIMATRCMLSAEYFCSGSVARDTFSHYGLAAGMYTHFTSPIRRYADVLAHRQLAASINYEPLHPSLHSKDYVDDILKVVNKRHRSAQQAGRASVEFYVGLSIAERNSSSGKEAGLNASAYVIRVFRNGIAVFVNQFGLEGLITFKDELDFDQEAYQVTIPKSVSGLKRDRKLGIFDQCTVSIGVTKDANTKRGKVAMHLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU15</accession>
    <name>W3VU15_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU15"/>
    <dbReference type="HOGENOM" id="CLU_028549_0_0_1"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="151"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="643" mass="69625" checksum="B285815A9EC9E133" modified="2014-03-19" version="1">MRAGTKRFALRVSPTQRSPEAGCDSAKAFDAATEPRSFGCADELDPSPLPLIRNMLLKPASALLRTVASLPQAEVPNLLRFQSLATTSTRRSHVPTLRDQLSSHRFLSYSHAPRLEMASQSSAQEWKPSKPRGQQRPSDHKTGTKGEPMTPLPSATLIVLCPRSTREPDGGLQYDTLMVQRSARDGSSFRSAVVFPGGALDLVDEAEVEAALQSTTPGTGADAAKERYMLALKLCALRETFEETGLLLLPSATPSASGLPTSRAVGHQEAGMSAEEWSHARNDVHHNAIDFAPFLRRVSSKLGLTGKLGAGDAALPELAPMAHHSNWITPRSVVRPAKRFDAHFFVTVLDTPDVFGDDKSLQISADGAETLSLRLQTPREIMYAGITDQISLFPPQFYILADLETALRAATSDGRVPIIPLIFDPSQATDRVSADAEFRVTPVEEESRGLKGRNYSWDRKDVPSSTAPLTSWVSDTNPPLSKLRALGSDPDSSFPEVTAVEPRAFPKLGAMLDIRKEIDENRVLAEQSSEGIDTEEREDSFVFPLVLPGDWQASPAQQQRARAGLLLPGGAAESAAAQASEQAPPLKGTPLNRLYVSPRAPEHGGGMTVRGAVRRGLAHLRDFQVGVLLAQPTEAEEQQRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUG9</accession>
    <name>W3VUG9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUG9"/>
    <dbReference type="HOGENOM" id="CLU_299373_0_0_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="4">
        <location>
            <begin position="500"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1002" mass="105354" checksum="13EE7D844366A088" modified="2014-03-19" version="1">MSVRPRTSCWAARDASRDQDAIKSSSVTTCAAVSFLLSVLSSSFSANVTALTLSGTKLDVIMGANDTKTLKRPVKSVFVPLSSIGHDYLPLLRALVTVCAAPNDASDASSTAGIDRAKGILVNCALWLVRDIRSAQELYTDLTFPQHVRNALETETSEEAALKTLLMLGQAETNGNAVTSAITSTLFTATQTANYALYAHEFEPAALDGATPASSGACLPFCGGALSAYAIAHKHRGEAASAGPSQSSSINACRMAFWMGLSSDRVAARHARQHHLVEDHAERHDLGSWCCVVLGWSEEQVQRVLEQMPGNERPYISSITSPTAISVSGPPLQLDCLQSIVAKQKGARTVRAPIYSPFHSNRWMQEASDEFEALCHEQKIGQEGDALPPWLSVYSSFTAVQDQQACSSAAGLAHLICRNPARYSEMVENASRQAVQLLQQQPSTTITVLNVGPGGGLGQSLAKRLRAVGVPDEKVELVDLEKTIARASLLPQLSTASHRKEPLAIVGQAFRLPGGANDSETLRQVLKSPPAGLITKLPEERFVIDDYVNEASAGSAACTLTESGTYGAFLKDVDLFDAAFFNISPREAEQMDPQHRLFLMTAHEALEAAGYAPNKTPTNRRELVGTFYAGTHDDYRDNASADIGSYLITGNGRAFASGRLSFVKDLGGASSSVDAGEASFVAAVHTAAEHLQRGQIETAVVGTSCLFTSPPNWVGLDKAGALGKGVTADNAQTPFEQGADAWTRSEACYTLVLKRLSQAEAEGDEILALVPGIAATFSPPAASTLTGFKQPALAPRGDGLASQVRSRASTMLAALQLAGLKPGDVDLIEANASGFAADEAVELDAIAAAFNSFGTSANAKKTYLGSAKGVFGCAEGAAGGVSLAKSLDCILTNSRYPEKQPGKRNPALSTLAKSNIVLGDAGHTEDAGVDVVLINSYSSGGANTSIVVQRYTPPSPASAGNTTPAAEVEGKKRSFVVGLAAKSAASLQQQAAAWHSALQWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUK5</accession>
    <name>W3VUK5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00964</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUK5"/>
    <dbReference type="HOGENOM" id="CLU_047877_2_0_1"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="403" mass="43199" checksum="892A8CFA562BB187" modified="2014-03-19" version="1">MYQPQGGGYPSRSPPPLQHPIPTHPPFKVPDPPISPNPVPQSSVADPHVSSASRRGGPAANLQAAAGGGYQRFASPPIQSPPNQSYASSSYAPVGGNAGYFPNATGPNAGQAQGWGGFPGFGGAGGPPIMNDATAQMGVQFGQHMAAVGGEYVQKNFNALLPMPVLKHYFNVSNSYVLHKLRIVLFPWRHKPWSRAHRHSSGGGHVSSAYAESTSAVKTASSGADGYLPPRDDVNSPDLYIPTMAFVTYIIVTSVILGLESRFHPEVLGLRASRALAIVLVELAAIKLGTYLLNIQGDHTMMDLLAYSGYKFVGTLITLLVGLLQVRGLVYWSVFLYCFAANAFFLLRSLRYVVLPDPSSPSSQTITHAQRSRRIQFLFCIAVAQIVFGWALIIGIFQDAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVC6</accession>
    <name>W3VVC6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVC6"/>
    <dbReference type="HOGENOM" id="CLU_125186_1_0_1"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000056">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="86" mass="10022" checksum="3E6A043B1B043A19" modified="2014-03-19" version="1">MSGRSKVSVQPINIIFRHLQQQTRVSLWLYDNVDFRIEGKIIGFDEFMNVTLADAEEVWLKKDHKRVELGRILLKGDNITLIQPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVL6</accession>
    <name>W3VVL6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVL6"/>
    <dbReference type="HOGENOM" id="CLU_014633_1_1_1"/>
    <dbReference type="OrthoDB" id="76038at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="691" mass="75535" checksum="691BC8F24DC17840" modified="2014-03-19" version="1">MLPPHRRTPEALVLPKELTSLAEHTPPMCGMPSADSNSATSHLLLPGSESEAVAHFDLVIIGGGPAALAVVSRILESRPAALYTEDEHRHLHFVHRQRTRSFVPKKSHKSTRFDANTERSVLGDDDAACACEGRFKILVIDRCGEGFMGLWKRNFNALGISHLRSPMFFHPDASDFDALLAYANQTERANEGTPDQLIDQIESRVAAVRVVGQEAKRRSKRSTSVPSDRAHGSLPHLIEIPSVVGREKSKHKRKQQQQLLGKSGPASVHVNERDRRDYFTPSSALFGCFIRRLEEKYGLNTAAVWPSVQQFFNASASDNQEAQQEQPVTTLHGSVKDLVWLDGVQRCVDDGLGNHRAGFLLELEDNDPVRNGSVVVSAKAVVSAIGAGGKPSIPPFLTQANNAEASGSGTGKSAASAPRGKGWMHSGCLAWEPFPTPRQGHRSTMVVVGGGLTSAQLVVRALESGYDRVILLVRGHLKSKPFDVDLGWVGRYSNYLRMQFWQSDSVDERVNILRTARNGGSVTPTYAKLLSRLEALGKLEIRTHTTVASATYDQDWTLNLRTAHGVQEIRADYVIAATGAETNFRNLTFLSTLQRTHPVSVVAGMPLVTADLEYRRDVPLFVTGAYAALQIGPGAGNLGMMRDSADRIANRLVQLIDPPQSQPARRQTTARSQAESAAPTHFNFDLLSIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVS2</accession>
    <name>W3VVS2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVS2"/>
    <dbReference type="HOGENOM" id="CLU_059852_2_0_1"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="271" mass="30555" checksum="24C9857DC43A6358" modified="2014-03-19" version="1">MASYLASIYGTEQDKVNCSFYYKIGACRHGDRCSRKHIRPPYSCTLLLSNVYRNPRHHEQDCAITDAELQAQFDEFYEDMFCELAKYGELQEMHVCDNVGDHLIGNVYARYKYEADAQLAVDALNDRWYDAKPLFAELSPVTDFQEACCRQNETNECNRGGFCNFMHLRYASAPLRKQLNHQLAVELKKRKEEAKAAAAAAGSTRKLGWKERLALDQGEELSAGDAEDAEAPPKRDWRSGQSGGDWKSQPRAGTGDEDASDAPHQAQQADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWJ5</accession>
    <name>W3VWJ5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWJ5"/>
    <dbReference type="HOGENOM" id="CLU_1004712_0_0_1"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="274" mass="29386" checksum="EB74C9F40035732C" modified="2014-03-19" version="1">MARRLVSYSDLVDEADASLDAHGVVGGSKRKRGQAVGGLKHWDDPSSSLDGAKDDGADQVDAIQEGLDEGTGEGYVWKYDEWGRLAGDTTTPVEQDYDFDVPFSIPSPPLAYSDFKVQEDVEEITHRPPVEVGGGGRTLLHSEIWSASAIVDAFKAAHHQYLAHHIPTNTNAAPASALWTQAPHHKSLLAQQVKADTLQILAQNKPSSKSNQSSTTSHQSTATHVPAADMDGNTAWKKAVKTVQATPNSIGSSEWNAGYSAGYNDALNHLPPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD21</accession>
    <name>W3VD21_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD21"/>
    <dbReference type="HOGENOM" id="CLU_1440868_0_0_1"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="189" mass="20949" checksum="214BE0CCFC81DD23" modified="2014-03-19" version="1">MSASVTLRKRRSVASRPITNRPQTITGQQNKALDAEQERERQAKQLDARRRRARRRLDELERINYRDAPTASSSASGVSTPLESNEASGVDTESAGSASAGVSVAQRRRNQAEIKRILVGGRRNLHALVEELVDQGRLPLVPGKDAANWRSVRSAPPTRPARRYCSICGFHGDIACTSHDETRCDRPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD30</accession>
    <name>W3VD30_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD30"/>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF7">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38884" checksum="7B292EAFE9D45706" modified="2014-03-19" version="1">MLSVQTPVAPAVLKHDVAEPCTITASAPKTDAHLDAWHRDLLRDGYCVVKGAVPQERALQYADKMHGWLEGFQLGYDRNDLSTVHKDKLPAITEKGMCLNYAVTHEDWAWKIRAEPGVVGAFEKFLGTQDLIVSFDAVNFGFPNRKDLPPNKPWPHQDQDPLKPGFRCLQGLVNLLPNGPDDGGLIVCKGSHALSTQFHEEMAWEEKIPAWTNEWYGFTDAGMKWLADHGCEWIKVCAEPGDLLLWDSRTAHYNLSSKTDQPRFCVYTCYMPVADASQEDLKRKKDAFERRVGTTHWPNARHTGSNVAKRDAIDDPHNRDRPVEEPQLSERAFRLTGIPYIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDA8</accession>
    <name>W3VDA8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteine synthase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_06434</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDA8"/>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_1"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000072">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="108"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="291"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS59515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="533" mass="57537" checksum="C59B26837C043E18" modified="2014-03-19" version="1">MSSLGARASSSASTSKLAHIPGWGVITRYSRSHRKSTFLIGVFTGLVLGLGSITSVFFLAERRERRRRRRKLRSYGLDEEDEEERRRRELRGRDPIQIRSGQVVRGVEGLIGNTPLMRINSLSDATGCEILGKAEFLNPAGSPKDRVALQILCDAEDEGLLYPHTGSCIFEGTVGSTGISLATLARAKGYRCSIVIPDDVAREKVELLTKLGAEIQSVRPRGIVDPRHFVNEARARAEAFGDVELIGPHPTGFGTSGYAGSDGGQGEEYVHRDDLVVSSRRPAGDVDADAPEMVSENQPRGFFADQFENPSNFWAHYNGTGPEIWRQTGGLIDAFVAGAGTGGTLSGCAAYLKRVSCDPDESMRAGGFIARPGSAQEVQVVLADPQGSGLYNKVKYGVMYSPTEAEGKRRRHQVDSVVEGIGINRVTRNLQMGLQCIDDAERVSDDEAARMGRYLILNDGLFLGSSSAVNCVAAVRTALRLKRERGGDPPPVVVTILCDSGARHVSKFHDDDALVRLGVADAGSADISDILHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDF6</accession>
    <name>W3VDF6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDF6"/>
    <dbReference type="HOGENOM" id="CLU_015848_2_0_1"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="765" mass="84083" checksum="DA50BA713E10B5CE" modified="2014-03-19" version="1">MRLRKQRRASFASTPSPTAAAATASVPRARNASAGTQPSSSSDSDSSTDKHAEAAPSADAGFTYPPTDPSPDAEKTLEERRRRTEDAKKLAKAQLFLNSEVKRASTDALSFRAAASVTPVPTNLGSVTSESGSYLARLSAQAVAAEAKRSRGHRHADDEDDDDDDSLYDNRRHRHGRPSAHGIVRRMAEKHHRKVEKREKRRRTERLRRIAALDPLKEGERQHGQAKETKFMALIRKYGDMARENERQTKPGSTVDLTAQESRTEDTTPSTETSSLDEHSAYLVDTLEVVDPGVSTAGHLSNIGNSLIFPNIPGLYDRRPVIDLPAQEVDASAASTEAQLQLEEGRLASPRLKAKAAAAASQEDEDDLHLDAYVHELLTKRQKFKRGMQGVWAFLKTPVGVIAGIYGFLVVFGGAALVLFLVGAIDGGKNKDFWVEVFSQFENGLFTIPGVGLIPWRLRDTWRAGWIAYYQHLTWRLRKKQGLPRLADKNDIPSVVAPKRRSKSRKDQAKTVAAENGEKEPAGEAAGEAAGTLDAQDGSSVGELGRPGSKLSAVRRDDEGESRDDDDYDTSDDEDDEHTLALSPDVVLSPSQAAKLHELQVAFGESQSWYRAHETFTHHAFSISYAVWITVMNDLNSLFQCLLCGYMWGYATHYRDRPAWSTGTFMPCSFLAGIGAAVLIWKGGEKSKKKREVEEKLLAAFARDIDAQVEQIRRENEARLNEPALETVHEVDHPAAEGSSPARADQGKTGLDLDTLATEIAAKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDN5</accession>
    <name>W3VDN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDN5"/>
    <dbReference type="HOGENOM" id="CLU_000288_5_5_1"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="287"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="609" mass="67363" checksum="AAF2948A7EE9650F" modified="2014-03-19" version="1">MSHPRQAAASGASRHVTSSSSRSTRRSLSPSRASSNTEPPNKRLRKEDTPPNDADPSLDRLLDAFDSGIDEEQQRRRVLEESRKRRQAILDKHRGSQSVQASEGTPAPSTAASAPQSEVKEAQPPSQQPFSLVKTATNTTDVAADGSANAQDASAAELDPDADRAQELKRLEQRRRVAPTVPHPSKSSEQQEFQEIEVTDDEDDDDMDMFALSDDDDAPKPDAKPRKTKIIRVRLRGASASSTSAVKASAAPISDPAAASTANLSSNWDDNDGYLRTILGETLDERYQISAVLGKGMFASVVRARDLRSDGRQVAIKIVRVQESMYRAGLKEVAMLRKLNAADPDDRKHVVRLERHFEYKGHLCMVFESLSMNLRDVVRRYGRDVGLNLQAVRVYAHQLLLALSHLAKNEVMHADIKPDNVLVNDAKTTLKLCDLGSASYVSEMEITPYLVSRFYRAPEIILGQLYDCAIDVWSTGCTIYELATGKILFPGRTNNHMLLLMQEARGRFTAKQLRKSQFGEQHFDDTNAFLGVEADKSTGQEVVRRVMIGRPSADVRSRLLPADAAKRLKPDEVKATNALIDLLERCLELDPAKRISAKEALGHAFFANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDN9</accession>
    <name>W3VDN9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDN9"/>
    <dbReference type="HOGENOM" id="CLU_004513_0_0_1"/>
    <dbReference type="OrthoDB" id="5593376at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="866" mass="91255" checksum="A32FD9FD85F625D6" modified="2014-03-19" version="1">MQDSGSVQPQQQQQSVDMSDYSRTGQVSPVVRKRPVQSDSDLAEQPSKSHRSEIATPVQPPAAPPSAPPTVSGASMTLSQAQVPMPAQSAPPAQMANGMPGGVSHALLANVTSLPNGTQSLNASPTTPQNGFEFSQAQALPGNAVAQSMPSSPSLHQHRHARGGSLQDAMTMSAPIAQNLGNSEVQHYGERSQSKISRSALQMSAISSSSTSYNQSAVDSGPSSPDDSFSNGEESGDEGNQADETGQQPRLTKHRRHRSSGFFSSGASFDFGAPEENGGGDSSAANGDKNAPTTALSPELRSQLESIFHKFLTAVCSDLEITDDRGELLHQTLMPKKMARLDESPDFRPFKFRIQAFTNAFQAEVYRNGISESECSIKKIKQFLWTQPYISRFNEDGKKAKSKGNHIWIVEAKKIPEGGWEFREFTRKIAGAPEKIAYVGLKWTWPLKVWDPQASSTSIKAVFSCNQVPSWIHWEENNRILSGTPTAGSESGEVSVTAHYVNGGQLHQLQHSFYLQVASIAADELQANDGGPAASTGALAAELASGLNSASSEPSVNVVTGSMPPAHGVAPMLPQAMHPGLPPPGHAFINGQPPANFPSESINHQIVEPSKVPAVLNAIAFPFTPPVHADARPQYFQSLVNEAAMLTPQLSDVPGANAEAGRSNSQLSSALASPMPPQLNPSSFPGGAGEQLVGAPAMQAPASSQALQQQLQSGLSMPPQSAPLAASHLESQPPNGKASSEEIQVHQVRSLIERKQQAQAANFMLSIPSRKAAIAADAARPTSGQTTPMSSMPSDMVAQLPALSSMPANESMSSGLAPNAINGEATLSPALNVGFDALGEAGMQLGLQNEQAAQMQSGQQHGGNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDS1</accession>
    <name>W3VDS1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDS1"/>
    <dbReference type="HOGENOM" id="CLU_032222_0_0_1"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="93"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="438" mass="46432" checksum="7585AB5819585783" modified="2014-03-19" version="1">MASSPPASSPNAPQTPTNDAQSSHAAGATRERSNSSVPLAKRFKLDHAEASATPGASNPTNASINGAKPATTAAAAAAAAAPEQRDNFDSLVDVMGASGVDLQAEEEAIQRREQLMQQSRTAQHRGAQPDDDEVFLQIYPLAYKVHTLAQQHGLSVDAAVLNYLSLAARTRLKNMLEAMIASSRHRSWSSHHHAPPLYASTSQPMYDEQILTDPAKQLAAVEKAERGDEARRRRERLARDEESSAAAAGLDADMDLDDGTTKADGRKRPKKMGPGVAARNMSEDVRKRLADSTAMRNLGGGSSKYSWLSGGSSFPGSFSPLGAKKSKPDADDAKSASRLPKPKFAPQPAVSNWSGGGASDAGAAASSNASTGAWGDVTARQAAKDQEERQARLKVTLRDALFALEYERRAGAGHGSGEALLYRIRAGDDHFLKAKEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDU0</accession>
    <name>W3VDU0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fox factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDU0"/>
    <dbReference type="HOGENOM" id="CLU_007783_0_0_1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="526"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="526"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="796"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="917" mass="99744" checksum="3A352A55533D0055" modified="2014-03-19" version="1">MLTSLRPRSPPFFDVAARPQPHHITSTLHPAHCGTPAYPSQMEGSGARRYTTPPPGRQAPPYQHTPSHYLADAGPHPLEQRPSPQSRQRSWHHPYMPSPRGAQGPSPPAPLEAGAMPLTRAPDYAPHDPLAHGLRHNTSPSYRSEPLHPAPDARSRASSRAEAQPLSISTLPTHPSRDVERIGGIGPSRNRGRSSTLTLPHPDTARVRGSSFIGARQHTPSHGPVHVKYDEQSPLPPRSWDEGRSFRDGYHNHGGEMYAHRHHSPGLRPSSRESPILFAPLSPSQDPHMQVPRRISGGQHGNPSVMARPGQYRSRPGTPVSPLNMEGLSMEEVSMPSASGMAVPSLHGQGRSPAEARVRNDYFGPAAAADWTRQKHKNGDLAASPPSVSYAPGPRNDPRDYSYRPATVMHGEAISPESEMARYHQASYPVGQPPMHPGRAPGPEPIHHHPSRSRLEQIDRERFAAPHHPVAASPDAYLGAGATQDHGFHAEYTSQPRPRSAGTFVANAPQQNAPVDRIAHSRRRRRPPYSYSSMITQAIASSSEGRMTLREIYTWISSNFSGYPMAGPDSQGWQNTVRHNLSLGKIFIKKARTAQDIYDSCSSGNPSQSQAARGKGGWWTLHPVVLAQIRSGQRTHNDEFDDVERLVETENAAAKEGAVARVAGAAVMAATSSVSSADGRSAPRRSSAEISQHKTLSRQRSYSDSMDPTTVEHRRVGPSQHALTAPVSRKTSIGASRNEANARTAYAPYSSPLSDRRISGSSSDRTRVDMPSVLQTKLGGGANDERVQAFGRFRGHTIGGLESSSPRRSNSMSHAEMDGAGEEAHAHVLMRLQPDVSTSPRAAGRVRAQMVEDVEMEPWAASPRPSSVVLQEARETLANTKQQQQEQMLRQAHEDKVALADAPEGAGRMAIRGLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDW9</accession>
    <name>W3VDW9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 12">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_06246</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 12"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDW9"/>
    <dbReference type="HOGENOM" id="CLU_026967_0_0_1"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="17">
        <location>
            <begin position="27"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="18">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="16">
        <location>
            <begin position="373"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS59724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="457" mass="49524" checksum="9297F283854426C5" modified="2014-03-19" version="1">MVRDRIEALSHHLSSPTPTKMSTPTRVFQLIPGVQSYDWGIPGSKAPRVAQFAAATKQLNFTADDDKPYAELWMGTHPSMPSRIIPTESSATGEFTPLAEHLAQHPELIGERVRAKFSDGEPGALPFLFKVLSVGKALSIQAHPDKALGKKLHAQRPDVYKDPNHKPEMAIALTPFRGFCGFRPLAEIVAYIKNIPELAELVQLSDDDVARVASLASSPPESDEVKQTLKTIFGNLMNAPKSTYEPLAQSLSERFASGRVDSVGETERKLVVKLADEFPRDVGIFCTFLLNISTLQPGEALFLQANEPHAYLEGEILECMAASDNVVRAGLTPKLRDTDTLISMCTYQSGSNRGRLEPTHWAKSTTVKGTAQALLYDPPIAEFSVVTTTLAKDAVVQEAQVDGPSIVLVLEGEVEIEGDGKVSVAKGQVAFVAAETRVSVQNVGDAEAKVARAFVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEC6</accession>
    <name>W3VEC6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEC6"/>
    <dbReference type="HOGENOM" id="CLU_021161_0_0_1"/>
    <dbReference type="OrthoDB" id="2556825at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833092" description="F-box domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="593" mass="63499" checksum="EC9A41661C7BC92D" modified="2014-03-19" version="1">MTAALPLEIVDLILLLSLEQGGGSIRRGREALLPQGASTSSSTTSPASSLSPAALRRPEQVLDPWQAAAISCLSRHHRQRFEQQLYRHVYLHDVRTIALLCRTLSARPDLCHHVRSLALFCDPSDGSHRLPSGVPTADFVDGVPEPSADITSAADVILSACPNITHLLLSCDHFSSLSAGIYRLLQPKEITLVSVASVAVLDGIVKRHRDLTAAALQDDPRMRAILGTALSAAPDEPSPIGVTLSAHESSPVPSTAPPSPHAERSLSHLHLVNFDGRLLHHLATLSSLTHLVLTHPILPETRPGMPGLSIIPRSHLMLLLGSGNVQRIVIRADLATCIRLVEELAPIEDQKLVFRPLAKSGDLLFPEPERRPRFSAALIAQASSLYDAVAASKLDLLSEFFGRVRVHAHRFESSLSSDDPDTSRGSSTGFRHPRSSDSSGGATSQSASTGWDDDGSDDVDDEALQDFGPEDSPEPPASEDPGRSVAATAHASTSINAPPLNIPIEELLRAERFTPAGLARTAAPASQASSGSHDLSSSASSSPHGQRRRLHRSPFALRKTDLRGATNSNLDILANLYEALASHAGLEQEMNFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEI4</accession>
    <name>W3VEI4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor RLI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-binding cassette sub-family E member RLI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEI4"/>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_1"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="71"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="330"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="606" mass="67668" checksum="A8A0652211BBB720" modified="2014-03-19" version="1">MAPAPAEKETRIAIVNSDKCKPKKCRQECKKSCPVVRMGRLCIEVTPSSKIAFISESLCIGCGICPKKCPFEAINIIKLPTNLENETTHRYSANSFKLHRLPTPRAGQVLGLVGTNGIGKSTALKILAGKQKPNLGRYDDPPDWQEILKYFRGSELQNFFTKVLEDNIKALIKPQYVDHIPRAIKGKASVTQLLDGKLERNNKDEVIDMLDLKEVLDRDVQNLSGGELQRFAIGMSCIQNANVYMFDEPSSYLDVKQRLNAARMIRSLLDSNTYVIAVEHDLSVLDYLSDFICCLYGVPSVYGVVTVPSPVRDGINIFLDGYIPAENMRFRDESLTFKISETADDEVLDRTPKFTCPPMTKTLGSFILNIEGGEFSDSEIIVFLGENGTGKTTFVKMLAGKLEPDAGAKKPPQLNVSLKPQTIAPKFQGTVRMLLLKQIKAAFMHPQFQTDVVKPMSIEAIIDNDVQTLSGGELQRVALVLALGKPADIYLIDEPSAYLDSEQRIIASRVIKRFIIHSRKTAMIIEHDIIMATYLADRVIVYEGQPSVKATAKRPESLLTGMNSFLATLEVSMRRDPTNYRPRVNKFNSIKDKEQKAAGQYFFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEK6</accession>
    <name>W3VEK6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_05940</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Responds to activation by environmental stress by phosphorylating downstream targets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEK6"/>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="222"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS59955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="555" mass="61908" checksum="CB0C0EEA4EC0F837" modified="2014-03-19" version="1">MSARRPASGVAVFEAASPTRTERGAPSGVSPNRPAPPIPEDQPPGSDEFGVPRAVHAEKAFVSAAAGLSDAAEASEASLGHGLWHRNQLVPVSQLGERSFFSPQKFGDAGRRVWPVLENRRTDQRILALNCAAAAAALPKKNADRQTHASDARSLLSSSWPGPGIATTQKASSSLAHPVTTTVSLAVIRTTIQSQHTHPETTTMAHGQQSNQSASFKVGETYKIVDVVGEGAYGVVCSAIHVPSSSRVAIKKITPFDHSMFCLRTLREIKLLRHFNHENIISILDIVKPDDYDSFSEVYLIQELMETDMHRVIRTQELSDDHCQYFIYQTLRGLKALHSAQVLHRDLKPSNLLLNANCDLKICDFGLARSANQPEAEGTGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGRDYHHQLSLTLEILGTPSLDDFYAITSTRSRDYIRALPFRKKRNFSQMFPNANPLAVDLMERCLTFSPRKRITVEEALAHPYLEPYHDPEDEPTAEPLDPSFFDFDYCKEQLSRSELKRLIYNEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF52</accession>
    <name>W3VF52_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF52"/>
    <dbReference type="HOGENOM" id="CLU_063339_3_2_1"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="78"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="202" mass="21894" checksum="129F84DE3B9D2C91" modified="2014-03-19" version="1">MSDVAHLKSLFRFYDDYPKKGIRFCDILPVLRDPLAFELLITNIVSHIFTHTIPTLDDATPAPAQSTPLEPGAKSYGSRKIDAVVGLDARGFLLGPIIAQRLGCGFVPVRKVGKLPGECVQASYMKEYGEDVFEMQKDALAPNSRVIVIDDLIATGGSAKAAGELVTKCGSKVVEYVFVVAIPFLKGAQQLDAPSYHLVEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF57</accession>
    <name>W3VF57_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF57"/>
    <dbReference type="HOGENOM" id="CLU_797393_0_0_1"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF23">
        <property type="entry name" value="DNAJ DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15460)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="337" mass="36011" checksum="36E0144451AE9FE9" modified="2014-03-19" version="1">MNRFPDIDPYDVLGLSPGCTAAEIKAAYKKLALKNHPDRAPLADKEDATARFKVVGQAYELLSDERKRREYDAFRPGSTQGYTPAEPYYEDRSRQHFGTSPNGVPFSFMWESSADSARRAQAGRRAGRPFGADGFDPFELFNMMFGKEFGSAGGAHMGGMPGPSRGPFATMNQGHGMGGSIFGDDDPFMQNHRRMADTMGFGFGSPFGPPRGHPGGHPGHPAHMQATGPFSHGHTTSTSTSTTYGGFSGTSQSTTTRTVNGRTETVTRTVDANGNVTVHTSAPEGSSVHINGVRQQNHPLLPNGAHPHPFVQPATGPTVPNHAGTGTPDNPIVLDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF89</accession>
    <name>W3VF89_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF89"/>
    <dbReference type="HOGENOM" id="CLU_003182_8_1_1"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="554"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="719"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="820"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="836"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="901" mass="98505" checksum="9615CA1E9876F6B2" modified="2014-03-19" version="1">MASQLQHQDEKPSLRQRGTDAFKWAIGYNDNEINRVGVPVVSSRDWLGNIFRHPGSKANDYFDSLFPFRKWIASYNTQWLIGDIIAGITVALVVVPQSMSYAKLAGLKPEFGLYSSFVGVMIYAIFATSKDVTIGPVAVMSLQTFNVVQHVLSHTREWAPETIATALAFLCGVICLGIGLLRLGFIIEFIPAPAVAGFMTGSAIQIAAGQVPKLLGLSKVQTNSNPAYQVIIDTLKALPDTNINAAFGLPALVFLYWIKWFCGWLPTRYPRTARTMFFVSVLRNAFVIIVFTVASRIWLGHYSNPKKYPISVLLTVPRGFKHIGQPILNTRLLSDLAPRLPVSVVVLLLEHIAIAKSFGRLNNYKINPNQELVAIGVTNLVGPCFGAYAATGSFSRTAIKSKSGVRTPLAGWFTGILVLIAIYALSGTFYWIPNAVLSAVIIHAVTDLVVPFSVSYKFWLINPFELIIFVGAVVATVFSGTETGVYVSVAASLALLLIRIARPRGRWLGIVRVHHGTTAPNESTITLSHRDVFVPLDDKDGMRDPSIHVEPPPPGVLIYRFEEAFTYPNASHLADLLIDRVKETTRPGKPASSQRLGDRPWNDPGPPNPHLVKAARAVTCRSRKNALDDSDALAAVRDTRPTLRAMIFDFSSVSNIDTTSVQTLVDVRTAVERYADAKVEFHFANILSPWIRRGLLAGGFGLGFPSKRITDVAPVVSQPQNATLSAQELQRREDAEAARRAKAIERMSHKSANEGSAYPFKGRPTKPLTELEAGLAGDGAAASRSRVDLHEDLDDADPDRILTTRKVAIGEALYDVHTLDEGQHAESSNSSPSRNSFEKDVEQGHREDRRPSNPESQVSVPFIWGNDLTPFFHLDLSAALAAASEGIGADSQTSSTIDKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFA3</accession>
    <name>W3VFA3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFA3"/>
    <dbReference type="HOGENOM" id="CLU_049343_4_1_1"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF38">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="313" mass="34340" checksum="5D7ADA426147E2BE" modified="2014-03-19" version="1">MTVNNIDLDFRGITPAPVTPFNKDGSVDYDAIQRLGSWLGSLPGVKGLVVLGHAGEGTFLTQDEQVKVIQAFVKSVDDRIPIIAGITGEGTEVAALEACRAVQAGAKAGLLYPSHGWLRFGYQPGAPQDRYKQVYEKSGLPLILFQYPDNTKATYSLQTMLDIAAQPGVVAMKNGVRNMRRWDTEIPVIRRERPELQILSCHDEYLLHTAFDVDGFLVGYGNIAPEALLELLEAGKAKDYAAARRVHDQLLPVTKAVYHRGSHMEGTVALKHALVARGILEHATVRSPLMPLEEGAEQEIFSAVKQSRLSRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFJ7</accession>
    <name>W3VFJ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YABBY protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFJ7"/>
    <dbReference type="HOGENOM" id="CLU_1058152_0_0_1"/>
    <dbReference type="OrthoDB" id="667577at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056775">
        <property type="entry name" value="YABBY_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04690">
        <property type="entry name" value="YABBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YABBY protein C-terminal" evidence="2">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="263" mass="28264" checksum="40B687F7966FE0EA" modified="2014-03-19" version="1">MHYWSLESMHARRVESSASLRRARARIGSGIAALPPAQPLCAAPAVFGASPVCECSHASQSQSSSLIDPSQSQKESGPKAGRRLGKRMEGGNFRARLHSKPRASVFYLESPRSNARTHAPSRLDRSSRGEGGKVALQHASGTSSATPERGGPQGELLKSSDGPRVGIRPGSTPLPRPLSSFAPPPPFQLFTLLIQPQINFYDMPPKKTGAAGAKKGKTSAYNKYMKDQLAVLKTEKPSLSHKERFKLAATSWASSKENPKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFM7</accession>
    <name>W3VFM7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFM7"/>
    <dbReference type="HOGENOM" id="CLU_900141_0_0_1"/>
    <dbReference type="OrthoDB" id="10466030at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832931" evidence="3">
        <location>
            <begin position="25"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="341" mass="37213" checksum="75700A1080738514" modified="2014-03-19" version="1">MKHLFRVIVVVWATRLLVVSQAAAAPMLPESVAEEAGNGALEALRSRLTPLQLPPAPHQFAYQFPPATFTNKVDELEFDLATLPKIRTSPAPKLRVYIIMDYKTPSPPYLTAKTETEKKSSAAFEDYRLIWWDVYMVGFHLPRKGNCFVLASPLGGLATERLFPQACEVFEIPAFVLLSSMHADSIGQSMGAAGAVLYIFCGRTSFLARSGFLSLIPPNRTIINMKVLQISFVIALAACTFSMVTAVPVPLGAGFEKVTREGASAEEDGIASLTNGLRKLEIKPPRRLASEVNDPSAPRYASGGAEKAKKLWEDLTIGESTIKRGREGETGSAARTSRQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFQ1</accession>
    <name>W3VFQ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_06574</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFQ1"/>
    <dbReference type="HOGENOM" id="CLU_012776_0_0_1"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF333">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 31 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="947"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="970"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="110676" checksum="C9EF3488B5BF8E9E" modified="2014-03-19" version="1">MSIDRGSPQRQGQASTSAPNREPRSPASPTAIQRHPFTRTPSNEPPRIHFSREADTTSGRLHPSSGSDATLALDLSSSSELDRASLDASVNGLSSSMDSFGAHPADTLAQSANPHASSATKYWPEPSGSHLRSAPYAVNDSDSQSSYPQHERNGPHARIPRLHTKAIGYTSSNDGDLTPIASTSRVAPPLVGVNLTDQQIADMTESDVSEYDDTSKLRRNRRGSGAGPAATSVFSSITKSLRGEPFWSRSASSYTPLTATRSRSLKKSKWNRNSKTDKTLFSSSTHPSSKDRTRPRRTPSIWTHPLRMILSFFSKLFRTAFGPIHPVTIILALVLIASFVASVTKLIIYILNPDKEPLPWRTYCQQQPAFPHAYADALAPVDVFVGVFSIDSAYERRHLIRSTYATHTMPLDPHTGTPTSNVQVKFIIGKPRQTHARRVALEMETFNDIVVLDMEENMNRGKTHAFFRWAAENATVPFLRAVEDGQNPASGLAQGSVLLSEPESRGQGHGQTREVLGGSTEQMHRYQVLWKKADYVVKADDDAFLILEELERHLRVAPRQMTYWGYLIRNWFMGGECYALSNDLVQYVAKSENVLHYIKGKEDKKVAQWINLHPNRSSIHWVSEHCWIYDHPKAGTAYSHGFLFPDYVEKIKLEGRRGLTDQEIARRGGEHRAKSYSTVSRWHSPYVEPRGDLTIEEEVEALVEGGGRWSGSWVRGEEGNDTQIWVPWQQIVFEANDERLRPPILDNLGAHPTLAEEVGIDPATGLTVRHIHAANRQASSAFAQADDDAVHAQRRKRDIPFLAHLPSVPGFDFGAGGVSRSAAEDRKRSFASSAMQPRMIPLPTHKDGNGEAEELRRRRYLGRRFGGTVVVHYLKKSEWFYETALAFAGRGRFWPDGAGGTGSEWRMYGSPLVRHEDGYISGGRSQPRPDMELAYLQQARVQAQANAAQAQQLSARMGSFTKPKPAAAGGPPPPKAPPQNSQPPMQPPQHQRPQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFQ3</accession>
    <name>W3VFQ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFQ3"/>
    <dbReference type="HOGENOM" id="CLU_012494_4_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="314" mass="35302" checksum="7429F74510AD28F8" modified="2014-03-19" version="1">MRTITFEFAKREVPVLLDLCLPDAVTSEPLPIFVWWHGGGLIQGARQVMAPHLKRAVDKFNIAVVSTDYRLAPQTRVPDIQQDMEDCLAYVIDKLPQELAAKGDAAKLDTGRIVLSGSSAGGWQCLMVGLGMCPNSKAEHLQRVKGIAAIYPIITMDHPFFLEKQTPFGGRLGDDSATFAEFRDPNAPVTANTAAVEHRKKFYMHAQQEGLFPSLLFSQEQRDQGWLQKTDVEVFLKASSEDQRRRFPPVYIVHGEKDTAVDVDHARRLNTTLKEVGASVIYDEVPGRDHLWDQLEPEENLEALWDFTMKSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFT7</accession>
    <name>W3VFT7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannan endo-1,6-alpha-mannosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFT7"/>
    <dbReference type="HOGENOM" id="CLU_028686_0_0_1"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833123" description="Mannan endo-1,6-alpha-mannosidase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39937" checksum="801C5A37BD6999B8" modified="2014-03-19" version="1">MLFSKYLSLLIAGLAAGSSSTAKPLPGLDVGRPQVDAGMRSLFAYYNGTDGRFDTSASWWLSGNALTAVLEYMDKTHSRRYMPQVLNTIEQQKKPLPWWPSGGGIFRADSTDDTGWWALAMLKMYDLTHDGKYLEYAVLDAEYLQSFQSSACGGGIIWDIPSRTYKNAISNELFLSLAAGLANRLPDAKQRAKWQNVAKAQYLWFVQSGMINSASLINDGLTDACKNNAGVVWTYNQGVILGGLVELYLADGHKREYLDLATKIARAVMSSSAFNSDGVLVESCEGAQKCNTDQDAFKGIFARNLDKLNRLTPGMPYTAYLKRQAASAYAKARNATDFYGVQWTGPVGQANVGTQGSAMSLLVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFZ0</accession>
    <name>W3VFZ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFZ0"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06621">
        <property type="entry name" value="PKc_Pek1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000626">
        <property type="entry name" value="Related to MKK1-MAP kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="206"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="665" mass="71174" checksum="E3102E23D43000C4" modified="2014-03-19" version="1">MASLIPPKKPRKPGMPKLTIPARPTSSSSAPGGTLQRERDEPSLQRPQLAIPNAASSSVSLGQPYPDDGYEDGHPGIDTSNASTIYPSTVPHLTNAHMHTAITDDLRRAIGGMSMADSDPERVDANGLRIPATGGNYASSGYWRSNSAASSSQAASIESSTTGAATDGATPASRSRSRADSSASVASNRAASSTGHDDELVLAGNFEMLSRLGEGASGEVHKVRHRPTGLIMAKKTISTSPNPAIHRQILRELAFNRSCHSDYIVRYYGAFLEDQDTSIAICMEYAEAGSLDAIYKKVKSRNGRTGEKVLGKVAECVLKGLSYLHERKIIHRDIKPSNIVVTRQGQIKLCDFGVSGELINSVAGTFTGTSYYMAPERIRGLAYTITSDVWSLGLTILEVASNRFPFPAEGEPPLGPIDLLSYVVNMKVPELQDDDKAGVKWSRALRDFIERCLEKEPTKRPGPHKMISHPFIRKSETRQPQPDIAKFVADVYGWSYLPSTIASQQQQQPADQQSHDTPTQSTASSATLNRIPSVRSAPIASATALHRVTSQAKQPAMQPPTTARAGADAAVAEAQLGSSSSSTRPRAPKISISVNAGRSSQHESVSSESSDAQPLQNVVLDAGVVGGRTRSDSQHRSHEERLAARLREADVGLIGSPTEAEGANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG06</accession>
    <name>W3VG06_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kynureninase</fullName>
            <ecNumber evidence="4">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="7" type="ORF">PaG_05338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG06"/>
    <dbReference type="HOGENOM" id="CLU_279523_0_0_1"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="817"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="785"/>
            <end position="788"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="875"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="897"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="927"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="955"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1146" mass="124339" checksum="EA9194BCD5DFB026" modified="2014-03-19" version="1">MSITTTMSESDATAANQAAEKQLQSSLLRIAIICASSIQSLREPVQPTILAAADDDAAASSSSSKPPAAHILAAQIVSDLSQLLTLVQKHSTNLALALKPSAKTAPPAPPAPSAPDATISPVSGLDAKSLEAAQAQIVALGNDLLPKIVFLAKKAWKDREVFQHRPNHLKNDPAQLEERRKLEQLAKDMGGQLMSADQLGIPPSERNDLEKKLEYSLGNSFAREIRSAVEDVLGSIADLLHSLLDDRASKALENASNARDRADGILASVGKKLDNLSLSSGSRDPAELRKRTLAANNLVWETCAKYIGERNPDGTPRTITSVAPSGARTKVHVKGLSKSNLEASKRSWNNRIELMRDGLDELKQGIDAENDPHAADLAADDADEFSFPAATPLSPQQKDRLRQISNLVKIGNLAHENILKQLVKAQSVATAAIDLDEVEEIGKQLEESQDELVAACLYGEVDAGLEAQMFDHDADDHPHGNANANGNANDDADADLTEEQAIEKAILRTLEQYIQAIVSLSAYVTDRDELVDKVHLACATDETGDFAHVFAAKFNQLSKVLSEASSDIVIRAPSASGPAGKATLQHTPTRQANDEFKSQIFVQELESIAAKIGSGAKITDRAIAEHLDSADPLRPMRDGYILPTFKDVCSPDYPSTSAETAPDAESLYMCGNSLGPLSRLTKRYLEQEIDAWGRKAVLGHFEHPYGTPWTQMEKRVGELCANIVGAKQQEVVVMATLTGNLHSLLASFYRPATMPFGVDFKGDVAAAKSEGRKTKHKIIFEQKAFPSDQYALASVVELNGFDPATSLVPLVPKHGTKTLDTADILATIEKCGKEGETAIVLIGGIQYFTGQLFELEKLAAKAHEYGILFGVDLAHAFANVPLALHDWGIDFACWCTYKYGSSGPGGIAGLFVHERWHQHNLTRQAGWWGHEKETRFSMPDRFVPTRGAEGWQVSNPSMLDMAALKGSLETLLKAADYGERNPRDEGAGDGKVGRGTVMPILRSKSLRLTAYLEALLLEPGFFPDGFDIRVVTPRDPLQRGSQLCIQIPDPPAAVAKREAEEKAQREQAQSAQSSGKEVPPPIDGKRLIARAHRRAEKQRGLVADIRAPDMLRLAPLAQFSTFTDVWRTADVLRQSLLEEVQEDQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGH3</accession>
    <name>W3VGH3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05491</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGH3"/>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="168"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="264"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="362" mass="37565" checksum="15552A615F5369A3" modified="2014-03-19" version="1">MSSSDKRSRPTAMHSLMAGTFAGAVEGFLTYPTEFVKTQAQLASNAASSSQASSSFADAQPKVKGAAGSVRFISYGALPAHKLNMASQAAAMAPSAPSMPKAGASAMQIVRDTWRAHGVTGFFRGAGAMVTGNSAKAGVRFLTYDTIQNLLRPKATAQGAGKEKLGMGRSIVAGFLAGSAEALLAVTPSEAIKTRMIQDSLQPKHLRKYSGGVDAVRKIVGAEGIAGLYRGLGATMLRQGANSAVRLTSYSVLKSMQAQAGYAKSTTATFAAGAGAGLITVYLTMPFDVVKTRMQQSPSVAAGSVAKRPSILACGMGVVRNEGVKSLWKGTTPRLTRLIFSGGIAFTAYETVIGWLNPEQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGK9</accession>
    <name>W3VGK9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGK9"/>
    <dbReference type="HOGENOM" id="CLU_866531_0_0_1"/>
    <dbReference type="OrthoDB" id="2555653at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833142" evidence="2">
        <location>
            <begin position="24"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="324" mass="35111" checksum="5AF1F67452C1BA75" modified="2014-03-19" version="1">MLTSQPATWLSALLVLAAPSTLAQSTASPADLAAQYSASPPSANMQAQSQAPPSLPATSSFWDNLGRHWTEADSTKQTLMAIFLICQLIGLFWFIKGSLDKIFGRRAEYRNQRTKRFARRAAIAAAGGLSKSGIPLSHQRPLYRPDSKPQLPPRPSQDHPLLRASSSSSSSSSSSSNTPAQAQFQTTPAGDIVLPSWTDAGPTPLRVIVEEPEYELSPINSPATSRPHSPAYPQHAAPSPDSPNHSWAFRSAPSRDNASLRLRERGDYAALPSPIDRSSTPDTRLEDVKRPFNRPFYAEPYTAQPSSNPPEFTVHTPSSSFSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGP1</accession>
    <name>W3VGP1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGP1"/>
    <dbReference type="HOGENOM" id="CLU_082764_0_0_1"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="331" mass="35505" checksum="C793BBAE0816388A" modified="2014-03-19" version="1">MRGLSALLDENNSSDASARRGRSNQSSTLTLRQRYLFTTCTIITMNVWSTTAAASVLKGTSLQGLSVARRVGTVRYQSRGAPSRDASQPAPPAQPAAPASSPAAPRAKPAGGEDERSRLARLQAQRLEELNRGRAGGARGGARSNRPEQRWSNRTLIALATSVGACTYLMGTYHGYNAGKAHVIEQAQAPVDSPTPSATSSAAATIGISASSVGFAERAVTSLSDLVAPLMPFRSLASPVHCEQGQTDAQTRARTPDCRLVELTQYHCDLHPTRVVCQPIDRIFRICKGRPAVEVSHIVEFDESAKPYLPADLSEAMPPSQHWHELRSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGU9</accession>
    <name>W3VGU9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGU9"/>
    <dbReference type="HOGENOM" id="CLU_2016228_0_0_1"/>
    <dbReference type="OrthoDB" id="2556041at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="123" mass="14036" checksum="1270F09616FD76B6" modified="2014-03-19" version="1">MYTVQHAIQAGKCDCRIYMLKLDHNRAYDRVRSEWLLDGLVAYGFGPRFINYIREFFKHPTLRQSVEGHMIDPVRLDCGLPQGDPMSDLLYALSLQPMRCYASGRGSLRRCAFVAAAHALSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGV5</accession>
    <name>W3VGV5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGV5"/>
    <dbReference type="HOGENOM" id="CLU_025221_1_0_1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="589" mass="63441" checksum="615915E586251C0F" modified="2014-03-19" version="1">MSSDNQASGSASVSDASGSNLPSSSTAQLPDPSLPAPNLGEDEVGFTAADLIAQQSKLEAQANEAIPFQFDTCTHERGNIRQPVYSCKTCGGGGVCAGCSVSCHAEHELVELFNKRKFRCDCGTPNLYRQREPNQAGCSTRLAEQLSYPDDAKPCTLRKPGFDPQNDTNSYNHNFDGSFCYCERGKTYDPEKEDETMFQCIVCEEWLHESCTSLRPAPLPKPVSGDDETGKASAASTTATRSADPAMPPSATEPEAPLIDHDLFDLMVCDACVRKPGNELLRRYAGARGWMIVATSQDAGEAGQYDGVASIQVPTEEELQNAGGPYQGRSWRIFGLAVEPEQALTQEEVSAAANGALLKSVAEIARSSGGLPSTRPEKEEQGNAHGAAAEISLQGAGLAEKKDGKRRAEDDPKDDQTAGEGSKRVKLEAADAGCTLPEGLSMIAKLGASVVDEWVPALSSEASETKPSQRCDVFLSDDFRDRICRCADCLPQWSALPHVLEAEETYAPPSDPQASVRDDDAASVTSSTYDLGMAALRAMPREKMINSLHAYSKFRDALWEHLKPFAGTGKMVREEDVRAFFQKTLNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH46</accession>
    <name>W3VH46_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04909</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH46"/>
    <dbReference type="HOGENOM" id="CLU_003041_0_2_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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            <begin position="477"/>
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            <begin position="508"/>
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            <begin position="711"/>
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            <begin position="1021"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
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        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1151" mass="125536" checksum="341B54B99FB68EA9" modified="2014-03-19" version="1">MAGYDDRDDYRRSGSSQHRSRTSKHHASSSHRSQAYEPTRRRSRSPPSQRYPSSHSHHGRADDPYVSGTDSTRRREREYSRDHDHHRQRDWTRDRPDHRYSATSSYSNTEDAAAKYSGRRRWDEGAPHPSDTQSNQAAMQGSRTHIADSLPPRPAAPIGAAPGPPPSAPPSLAPASTPSASTPVSAEEQAKLAKKARLEAWRKEQAAKKALEEAKVRAQNITDSVAPGTKKPEAASVTSAGPVAPTSINATGLRTLSLRADPSKVNAQNRSRSMMDDAAEPSGQKRMTRFDDLPPLDPTVGNHAVGQNLADDDEADNAPGEPDAKAADDMVVDDEEEEDPLDAFMSTVKSQVARVNEDDRRKAASNGNAAASRDKTKAVVLGQEESDAEDEASDTEVDELDRVGVATEDLLAIAAKKVKKKELAIVDHSAVDYEPFRKVFYHPPAEIDDMSEELANQIRLEMDAITVRGKDCPKPLTKWSHCGLPASCLDVIKRLGYDSPTPIQSQAIPAIMSGRDIIGVAKTGSGKTMAFLLPMFRHIKDQRPVETSEGPVGIIMTPTRELAVQIYREMRPFIRALGLRAACVYGGAPISEQIAEMKKTADIVVATPGRMIDLLTANSGRVTNLRRVTYLVLDEADRMFDMGFEPQVMRIVNNIRPDRQTVLFSATFPKQMESLARKVLKNKPLEITVGGRSVVAAEIEQIVEVRPESSKFHRLLEILGEMYNREKDARTLIFVDRQEAADELLKDLIRKGYVTMSLHGGKDQVDRDETISDFKAGNVPIVTATSVAARGLDVKQLKLVINYDVPNHMEDYVHRAGRTGRAGQKGTCITFVTPEQDRYARDIIAALKASGAHVPVELEKMAESFKEKLAAGKAKAAGSGFGGKGLDRLETDREKALKAQKSAYGEVDEDGKAAAAGDAGDGAGKGGTQTGASSSEEQLNKIQGMKIEIMHGAAPESVRDNRTVSSNDDASGGAGKGKEQEQEAKEAAQLKAQEAALEAAKAHGADTTKLAAVLENIRKQANARRESAKTSETDRAKERKARDPDATDYHAIVPINDFPQRARWRVTNKETMSHLIESTGASITNKGVFYKEGSEPQPGEPPKLQLLIESNTKSMVEDAVREIQRLLVEATQAALEAEARNPGTTGRYTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHE0</accession>
    <name>W3VHE0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="720"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="1214"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1425"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
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    </feature>
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        <location>
            <begin position="40"/>
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            <begin position="705"/>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="1568"/>
            <end position="1585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1682" mass="176939" checksum="888D0537C408AA5A" modified="2014-03-19" version="1">MASPSPRRLAQSDGPQAGPSSLSHPNHVSATPPTQADANQPPLRARLQALLHHADSHAGSSPALSPSSDTPSHHHSQPDAQSSATSLTSADQPLPSPAARPSQSRRKSPRGALSVLPQPSRPASATSIPSRATSPQPKPALLPRSITASNLDERSAHTLAPELLSRRPPRSSSLDPSHLPTGIHAASSAMDQAETQSSQLSSEKAETRQRPSIKVRIVTWNMHDSVPKGDLEVLLGKAGQFVAPQHGWDASYDSADEEGDDDSQPDRTRKGAHVVGQEHVPRADRIPPLPHDDSHPYHVLVIAGQECPWGDGKRLATSVGMAGELGDFGKQKNRAAKDKDKDSHKDKAKPFKSKEKQRSGDSDGVPSVVDGSNGAPSGVDASTAALNSKDGPAGPGDESGFPFHSTSMSSALPGNPLASPMIGGTSMSAFGPSSESQNDDKLAAWPNIGGKGWSDLCEDWLCRNQVAKKDREGKDGRDKSFISGARLARALSQSASKKDLAVSRENLAEHHLSMPMPSFSAAVTPELSRAASPVGLQFSASAPGTPNQSTFEGFNAYGDAQNQANPDAAANMASADKRRRLVPRLNLNPVDLVKKSAAAAAGRSSPATFTDAECVSSPVLLSPTAIQATASHALPHASQASTKAAANNPSTIPASTSSGALLAVPGTPTMSRMSSSHSLSKLAKAAADPVFRTASPAENGVLVEPPTPSRSPSPCPTDQEALRDGLVSRQTPSPAPSSLASHAAETGQNQKLPEKASADPIPKALGPYELVIKERMMGCYMAVYVWRGCKDRVRGASRSHVKSGLLAGRVGNKGGVGISLKLGTTRLLFVNAHLAAHEDKVALRLANVAKIKAALKVDSFLPPTDPRSKLEDITEQFDHTFWFGDLNFRIDISRQHADWLMMNKKYDQALAFDQLGKVLKDGDAFRGFKEASINFPPTYKYDVLKTLKIKRNKTLTSIRSGVDIPGAGNLAGTTKSTGFDLAGTPIGEVIPEEGAIGPEAPGRLGGDDTDDASFSCIAPGDPEPFSSQDESARTIPIAGRSDPAVAAMETVDLQDPDRSDEDRFSIASSSAFGSVASSSGFARAFKHEEARVSQGVDPALVRERELELERQRQLAENTSAAQGPRFFSQGAAIKAKFKIMDIVRNAANSNLKDKLGGAASADGQPGGKKKWLNVLTESPRKIPMPASFSSDNTSIVDSVMSMPSPTTDYSASFTDHNDLQRGGARRGSLLSNDGQLSSVGHGEIGTPRRGSSGDVQTPSSEHSVAFTGALPRRSSVQLARASAQALAAKAQREAKYPHLTGATAEQIDFLEAQPYDTSAKQRVPSWCDRVLFRSTVPLDDEDADESGDASAKADAHEARLGSRVGSALSNALITPLRQAAERRQQLHAQRSMSSGLIAAVAGSTTIAFAQDHKVPAEASLVDPAARKASMARRDRSNSRFLHPGRRRHQAKALSPSLTLSELAHEPGAGVSWAAKNSSAELLPTSASLGLGLGAGLGLAGLEHKALSSVDLPSQVEERDRRFGGVPKRVASPALAPGEVQARVVIPPRHSSSAASSPVVHAAAIQPPVRSTSATHMGTGADTSADASRGGWMDSLSSHLPAFLAPAFSALRSHRHGSTASIDATPASAADDTVADADADRLVGPRRGTIECLLYKALDDREMRVLEGRSDHRPVIFVGAIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHF4</accession>
    <name>W3VHF4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PaG_05694</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHF4"/>
    <dbReference type="HOGENOM" id="CLU_413428_0_0_1"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="22">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="23">
        <location>
            <begin position="313"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ETS60156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="636" mass="71088" checksum="5AF6D4C54D72CACA" modified="2014-03-19" version="1">MTIAATAPPLNGEVAPRSLRTSPRKRAQSPTRADASASTSTPAQPKQKKPRAQPVDESELECAACPAPGEPAPTPGKDAASDRETWICCTQCKTWFHCICIGLENPDDYSKWYCQPCITRSQQAFNSGTSTSRPPLANVARPPRRKSHRAKLEVDYAAIQDGIPADPLGRWRNFLDTYDFEPDRFPRMQGHEWTLDWLLHDEHALRQPVLVPASETPASTPVKRENDDAKGKKKGGARLVPRPTSIPGMVVPPAEMTIGDIADLIGHDTPVEVIDVASQSSSKASWTISEWAEYFAMPKHKKKKTLNVISLEVTGTPLQAYVEAPQLVRDLDWVTRDWPSERRDATCADNSWPKVQRYVLMGVEGAYSDWHIDFAGSSVYYHVIWGQKTFLFAPPTPRNLAAYKSWCSSTRQDFDWLGDHLHGLTRVDIRPGETMLIPSGWLHCVYTPQNTLVVGGNFLTDWNVATQWKLVGIEDATKVPKKFRFPHLKRLSWYVASGWNRRLSGMDRDETDEDRERILSSAQVEALVDVVPPKKVLEGIELVCQSLADDLELMQDEFILESGDERAVKQQKAAREAVPTHHVGSLAKAEAMLGELKERLERAMRVADQVDAARQGLASKARQNGNRAASPRKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHI6</accession>
    <name>W3VHI6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05078</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHI6"/>
    <dbReference type="HOGENOM" id="CLU_015910_1_0_1"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="744" mass="84427" checksum="2401A44EC78AF15F" modified="2014-03-19" version="1">MAPDHSQSPKRDVHNPLLFECAWEVANKVGGIYTVIKTKAPVTHQEYGDRYTLIGPLSYKTAPMEVEALEPEDPLLKETLDSMRDAGVKFLYGRWLIERAPRVLLFDTSSMYHRMDEWKGDLWNLAGIPTPSHDHETNETLVFGYLTAWFLGEYSSRERKRAIIAHFHEWQAGLAIPLCRKRHIDVTTIFTTHATLLGRYLCAGSVDFYNNLQYFDVDHEAGKRGIYHRYCVERAAAHCADVFTTVSHITAYESEHLLKRKPDGVLPNGLNVVKFSAMHEFQNLHAVSKAKINEFVKGHFYGHYDFDLENTLYFFTAGRYEYRNKGVDMFIESLARLNYKLQKSGSKTTVVAFIIMPAATNSYTIEALKGQAVTKQLRDTVEQIQARVGERLFDKMARYQGETGSDVIDPATLLSDADKIALKKRIFALKRNSLPPVVTHNMQDDDNDPILNQIRRVQLFNRTSDRVKVIFHPEFLNANNPILGLDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSITTNLSGFGCFMEDTIERGEDYGIYIVDRRMKSVEDSVNQLTDQMFQFSQKTRRQRINQRNRTERLSELLDWKRLGLEYAKARQLALRRAYPDSFEEDDTIESYFDDIHGDGKMPPPLSMPGSPSGAGARTPGEFGTLTEELQGLSTSDYKGHQQFWKTMSQHGSDDEEEAYRFPLVIKSRNRGTSVGSMSGASTPGLGGGKFLSSADLDRADAALSNHAPNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHN9</accession>
    <name>W3VHN9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_27_6_1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="789"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1358"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1462"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="397"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="894"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1215"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1553"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="839"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1106"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1689"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1116"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1149"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1701"/>
            <end position="1713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1852" mass="203088" checksum="1F37150E7B1F8DC4" modified="2014-03-19" version="1">MSTTLWPPLSSLPSLGWNRHPSIELTVILAAFNASHHSPASALSISTASVASVAASSDSGAQGLILCAHAAPLCIVLVATSAAVLRRLTRSSSRAGESGRKSTSSVASLLAYFAPFVTDQDVRQHRREQHNHSPASPASHLPKSAISLQGFHQQRKRLNRLLVVSLVQLVLTSTVTGYRIVADNAHAAFPFLSQSLAWALVSLRLFLRPPQTPSLLLAALLLSLTISSIVHLFSFVPWFAAQKVFASSQLAVVLLSATNVAISIYSTSLLLRMPIAPGGYEAVVDLDEQLRHHPDAVDKLHPTHQDLASTYQSCPTSPEDYCTLYENLSYSWMAPIQSLALRRSLVPTDVWRLRSINDTRLLFRKFKALLPPTPQDAPTLRTRLLSRILRANANDIALDACFKLISVSFAYLGTYILKSILDQIQLASANPPSDRANQPTQSVVPQSPDADLQWSPRQKAFVYAFIGLCLTVVRFIAELQNFHHARQVGLRLRSTLVVSLFEKALKRRDLSGQTKPTPSQSQAPEPTDAQADQLLEAVAIPDASASNTDQAAASIESDAVDHDRLHPVHAQASVLRNKPSRDTASGKLSLKQVSFGSIRSRVSQYAAYRKSRHAEALKKQEEEQGADVGKIVNMMASDVNILLRMGCDLHQLYGAPLEVTIAAVFLYKLMGWSALVGFSILVAAIPVNYVWGEVAVKKQREYSTARDQRMSLMTELVEAMRFVKIQGVESQWEERVAAARRNEIRKLIWSRFMTFLFELLWTVIPVLVTLVSFFFYVKIAKEELTVSTAFTAIALFTMIRPPLNAIPGFLMGGLIAMVSVQRLESFLNEQEVEEAISQLSRQRTATQTHSQAYRDEENAETPDHDSNNQLAIKNVTFRWHAKQSTAEAVVSRNDREQTTSQTDYSDFCLRDISVDFPAGRLSLIIGPTGSGKSSMLAAILGEMLESQDGQVIRNKFDTSGASRFSYASQLPWLENGKSVRDNILFGTPLDAARYQTCIHACALQDDLDSMDDGDLTQIGSHTVSGGQKARISLARALYARSDTVLLDDVLSAVDTRVQRHLVRHALLGTLAHGRRLVLVTHHVDLLIDSAALVVCLRDGEIVHQGSPAESKAAGSVTLSASRSSQQQNSDTGTDGDAERDSPHPVSRPASASSQQGSSSEDVPSGKLATPERPVELASGARTPRLLHQEEKRREGAVSWMFYRTYLRASSLRIWALLLILLLLLRLSESFGQYWLKIWGEAYSKSSLQIAAIAQLCGLQVSFPPAQGHTSFYLTVYGLSGLAVIAFNSSRAVCFYVASIRASQNLFSKLLTNVIKAPLRWFDITPAGRIMNRFGTDMDCIDNILPQSIMNLGNNAFSIAAYFLICVAIVPAFLLPSLVLVLVGPWLVGGFLACTRDMQRIEATSTSPIYGHFQQALSGIVTIRAFGTEPRLLESMLDAVDLYQSLWWAVCTMEVWLSFRAQILGGVSVFVVTLLALFGAVSPGSAGLALSSAQLLCQLAYYLVNDFKNLANSFNSLERVAEYQQMPREENEKVLARYTPNLPPAGWPSAQGRIVFDNVRLRYAEELPEVLQGVSFEVKPGEKVGIIGRTGSGKSSLAASLFRAVELSGGRILIDDVDIKTIPLQQLRGRLSIVMQDPVLFSGTVRDNLDPFKEHDDAAVLDALRKVGLAATPNGNEHDRSYEPSLIDLSDTEGDVVPRGQQAHDADARHKSSERSTNMRLQLDSAVSSGGANFSAGQAQLLSLARSLLRSTRILILDEATSSTDKETDAMVQRVIRTALHDNIVICIAHRLKSVIDYDRIVVLQDGKLVECGSPKELLSKDDVDESAFFKNLCKHSSEYQELCAAAGVLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHV5</accession>
    <name>W3VHV5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHV5"/>
    <dbReference type="HOGENOM" id="CLU_1031057_0_0_1"/>
    <dbReference type="OrthoDB" id="2556658at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="270" mass="26159" checksum="CCADEF55A7586011" modified="2014-03-19" version="1">MLCPIQEPTAGHGGVKAAEAGSPPNLAGEGGATAAHAPSITPACSKKRQTIAEVEFGSLRGWLKKNNSPTEFPRSCAPDWGLWQLASHPPSLTTISSSLSFSMARLAPTLLLAAISAAAVAAQAAPPLTTNNAQSACVQFGSCSTAGGNGVVTETQNSPVTQPAGTPALATYTTLDSAYISSLAAAGASSAYAALGGNGGASSAVPRTVTTSARGRATSTAAGSAASSSGSMGLGSLGSSNAAVAMSANSAALQMLALAAAAVLGAAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI16</accession>
    <name>W3VI16_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI16"/>
    <dbReference type="HOGENOM" id="CLU_053393_0_1_1"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="134"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="213"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="312" mass="35278" checksum="9D66C47621E18369" modified="2014-03-19" version="1">MSTSLAGRGLRAATRGWSARTIAAPTLVASRSLIVPSRPVYADQSSSSAAAAPGQQQQPSSDGTQPKQSLLKSLLHGSDKAKAEGVTTQSHSMQVARGKYIHEIQRQSVLPGHADAYRALIADFAPKLAAKGLPMRLTGSWEVVVGDLETFYHIWEYDGYAGYDKAEAALRQDADFEQFTKQLRPLLSNRSNWLTQEFSFWPSSPPRTTNGLYELRTYHLKPGHLLEWEQHWRRGLEARRKFVEPIGAWFTQIGGLHTVFHIWEYPSLEERKRTRDQAWQVETWNDTVSQTVKLIDKMHAQIMRPLPFSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI64</accession>
    <name>W3VI64_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04378</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI64"/>
    <dbReference type="HOGENOM" id="CLU_921749_0_0_1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="302" mass="32761" checksum="610931022B67015B" modified="2014-03-19" version="1">MLAAVFGYLRPPAVTAFLPSPSVSLGSTQHPSIPIDAGALTAHPLFGKLSFQFASLHASRPPSFVLQARSSLVHSPVPYHCVAFLPCRPAKSLTPRHTPRLSPSSPSFAIMSAPGSSTLRKKRKIAVLGSRSVGKSSLIVRYVEDAFVDSYYPTIENIFQKTITHKGQEYDCDIIDTAGQDEYSILNSKHAIGIHGYMLVYSIASRNSFDMVQTVHDKILNYTGTESVPCVIVGQKSDLHVQRQVSEAEGKQLASQLKAAWIEVSARHNANVAKAFEAMLGETEQGTQEGGPEPQPSKCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIL1</accession>
    <name>W3VIL1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIL1"/>
    <dbReference type="HOGENOM" id="CLU_022571_2_1_1"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="361"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="405"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="590"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="623"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="656" mass="71213" checksum="4D2CC332064BC1E5" modified="2014-03-19" version="1">MDALAGYGSDDSDVDQRVSPRRARPASTTPAEPLEYDPSDAFGLNSLRSNDTPTQDSPAQHAGTNSRDTRSTQKKSASSSAAGTASAASTSASSSVGTVALAPEVIDNSSAAEALLLRPDDSRMHVNIRYSDMTAAQLGPENPFASHAQRHLGAQQNTLTGHVETAAVSDFDFRNQQRTFHVYGYARDPSLLSSGEVQYIGDQAAAASMGGASAADIRASHASFRPATKSLRKKRGVGAGDASIVEGDGAYVGPWAKWQGDEDVATQLLGGVGGVGPSEAEVAAAQAKADERARDKAAAASARKQAEEVETVTETSIFHGKSRYDYQGRTYMHVPTDVDVNLSGEAGEQQCYLPKTCLHTFRGHSKGVSTIKLLPRTGHLLLSASLDTTVKLWDVYHDRACLRTFMGHSKAVRDIAFSNDGRRFLSAGYDRQVKLWDTETGACLDSFTNGKTAYCVTFHPDQDKQHIFLAGMSDKKVIQWDTNTHTVTQEYTSHLGPVNTVTFVDQNRRFVTTSDDKTMRGWDYDIPVVIKYIADPSMHSMPAVSVSPSQKWMAAQSMDNQILTFATDGFKQNRKKVFKGHNVAGFACQVGFSPDGKFLSSGDADGNLCFWDWKSTRLLKRIRNAHKEAVIAHAWLPHESSKIVTASWDGDIKLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ76</accession>
    <name>W3VJ76_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ76"/>
    <dbReference type="HOGENOM" id="CLU_050669_4_1_1"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="312" mass="33247" checksum="CE379291E2B2C5E9" modified="2014-03-19" version="1">MAMLPRAARPAMAAIHSAAPVAIAARAGFHSSAPQAASLRETEQRIKSVKNIEKITKSMKMIASTKLNKAQRAMAAAKAYGDANNEIFKNSEAVAPEGGRQLFIVVSSDKGLCGGIHSSVTKRTKAEFNKIGAAAGDANSSEGPAIIILGEKSKAQLGRALPKNISLSFNQIGKDVPTFADATAIADQIIKSGIKFDKVNLIYNKYVSAISFESDVMEVFSEDALRNATQFKLYEQEDDVTKDLAEFAFANAVYAALVEGHASEINSKRNAMDNASKNAGDMISNLNMIYNRGRQAAITNDLVDIITGASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ79</accession>
    <name>W3VJ79_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ79"/>
    <dbReference type="HOGENOM" id="CLU_008891_3_1_1"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="567" mass="61449" checksum="816E042F06447693" modified="2014-03-19" version="1">MSAIELINPRAESVRRTQALQVNTAGAIGLAQVVRSNLGPRGTIKMLVDGSGNLKMTKDGKVLLTEMQIQNPTAAMIARTAVAQDEQCGDGTTSVVLLVGELLKQAERYIQEGVHPRVISEGFDLAKTGALDFLEKFKKSPDMDRATLVKVATTSLSTKLHSKLATQLAADIVDAVLAIKPATTTTIEAPKPTADGSSESVSEWNIKDPIDLHMVEIMKMQHKTDTDTQLVRGLVLDHGARHADMPKRVENAYVLTLNVSLEYEKTEVNSGFFYSSAEQREKLVESERRFVDAKLKKIVELKQAVCDAPTEGSNEKKKNFVIFNQKGIDPMSLDILAKNGILALRRAKRRNMERLQLCCGGVAQNSVDDLSPDVLGYAGLVYEHTLGEEKYTFVEECRDPKSVTILIKGPNAHTMTQIQDAVRDGLRSVKNAIEDATLIAGGGAFEIAASNHLTTSVKKAAKGRAKLGVQAFADAMLVIPKTLAANSGFDVQDALVALQDEVAEGNVVGLDVQTGEPMDPVSLGIWDNYRVKRHMLHSSAVIASNLLSVDEILRAGRSSLKSEAPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJG2</accession>
    <name>W3VJG2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJG2"/>
    <dbReference type="HOGENOM" id="CLU_043579_2_0_1"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="124"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="423" mass="45254" checksum="E62AE0CFDBD88957" modified="2014-03-19" version="1">MEAEDAQKALRLAFKHDAGGDTAAAIKWTKKSIAIYKTPAAEALLIRLEKSGASGNGASAAASASASSSSAAAGASTSAEGLRSRASAQSNGRSAADTPHAAPKRAYTQAQLEVVTRIKKAGGDFYKVLGVEKTVDENGIKKAYKKLALQLHPDKNGAPGADEAFKAVSKAFTILTDADKRAAYDRYGGDPDNARSAAGAAAAGHGNPFGGMRGTPFRGGGMYADEIDPNDLFNMFFGGGGMGGGQFGGTTFTFGGPGMRTHQFRQQRPGARRAQAEPQNASILLQLLPLLVLGLFSLLAYAPSLFSTPDPNFAWTPSTTYKTQRMTNKHHIPYYVNDNQFNNHPFVTGERSQKDIAAFENRVENAYKQAMYSSCERQREYQERRLGATRGFLGIGGDEEAAKRIMAEVYESCENLKTFGIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJS7</accession>
    <name>W3VJS7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJS7"/>
    <dbReference type="HOGENOM" id="CLU_030988_15_1_1"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="148" mass="16694" checksum="0A94B1D3000EF981" modified="2014-03-19" version="1">MRIATKRLSKELVKGLPEGFSIIKADDFQEWQFSIEVLGNSLYQGDRFALRFRFSDTYPMESPEVVFMVTDGYKAPVHPHVYSNGHICASILGSEWSPVLNVSSVLLTLQSMLASCKQLQTPPDNDAYVKRAPLSPKDSRFVYDDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK39</accession>
    <name>W3VK39_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK39"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002304">
        <property type="entry name" value="Nucleotide binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="338" mass="36325" checksum="DDB0169F2EEA787D" modified="2014-03-19" version="1">MSASGPSVSPSASHLGADPKIVRRLSQVSNIILVLSGKGGVGKSSVSAQLALSLSSTPVADGRLARVGILDVDLTGPSIPRMLGLDGATVKQSTDGWVPVYTDASQQLAVMSVGFLLRSRNDSVVWRGPKKNAMIKQFLGDVRWGALDYLIIDTPPGTSDEHISILEYLRTFQPSAVMVTTPQAVSLADNLRSLDFCRKTQLPVLGLIENMSGYICPHCKDCTNVWGKGGGEALAKREGIHFLGRIPIDPGLVRVLDDAKEDAQQQLNQLEASDKPQAIDQPLTTETQQDSLTTAGTLLSRSTIHRYRDSLSFPIFQDITNQIRDKAAAHKANPTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKD2</accession>
    <name>W3VKD2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKD2"/>
    <dbReference type="HOGENOM" id="CLU_000022_2_17_1"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="445"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1215" mass="131369" checksum="B75D6D5C7F95E68E" modified="2014-03-19" version="1">MGVLDTSLDLDALFRRQLKATPDAIALVDPEANYTYAQLDAKVDSLAFYFRSHHAVGRDSLVGILMGRGADYPKGIANPHYAPVRSYDLRFAVNDLQAGDRVACNVYFVWEMLRPLLRGATTYAIPDHTSYDPVKLVELLADQKITETLMTPTLLAAVLARHHNLGAKLPALRSLWLNGEVVTTDLARRAISALPNTRILNCYSASETHEVACGDLRQMLSTLPDDAPYCPVGPPMDPAHTYILDEDQNPVQPGEPGELFVGGGLLARGYLNLVETTAKAFTPDTFASRPNARKYRTGDLARIIPESGLLEITGRVGGMIKIRGYSIVPGTVEKAIVDNFDVSNCAVVAHGEGLERQLVAYVVPDEGDTAGRTVLTIDDNGHSPSARQVLVSHLAHYMIPTLWVVLHSLPTHEVSGKVDLKNLPNPRAAIAAASGTHSRARSPAPDETVNLKSIAQLWALSLNTNPNTVLEAGKNVSFFDLGGHSLLLADLATRISKTLGGFTVPLGDLAGNPTLAGHVRVTLNARDGHNAAVQADLPTVLRADIELAPEFKLDSPEPVAACPLSQAKTILLTGATGFLGGFLLHDLFKNTSARIVCLIRFNAPYRTDRSAAMARLRRNMLDLGVWDHAMLDRIDVLPANLSRNRLGLVPEVYDDLVERVDVVVHCAAQVNLVYPYAALRDPNVEGTREILRLAFLSNATVQYVSTNGVLPPSQTGWPESTIMPLEEVPEKLLDGYCQTKWVAEQLVLEAAKRGLPANVIRIGTLSGHSETGSTNTYDLITALIVESVHLGVAPEIPNWHIEMTAVDFVSRGIVAIGNHIDASQPIYHLGDSEPIDCRLLFQHLDTLGYPTKRTSWKSWVALWNETRGSAKGGDHGLTVDILRSGMPSEEFLLGIIALKDDATRAALGDLQRPKVDAKLLQTYARHWYARGWMQRQPSSVPSTPSGEANGANGLALAFDPDFPLRGKVAVITGASSGIGAAVAKALVREGAHVALAARRVEALEKLQKELAEISRAHGGPVRSRVHVHKTDVVDRAQVESLMQTTTDALGAIDIIVSCAGVMYFTMMHNVQVGEWEQTVDVNCKGLLNVLSTSLPRLLPRSTGHIVAISSDAGRKVFPGLGVYSASKFFVEATLQSLRLETAGTGLRVTSVQPGNTATELLGMSSDQEAIKKYGEPTGAKILDTSDVANAIVYALRQPAHVAMNEILIEPRDEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKI1</accession>
    <name>W3VKI1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKI1"/>
    <dbReference type="HOGENOM" id="CLU_1469284_0_0_1"/>
    <dbReference type="OrthoDB" id="3366092at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="176" mass="19606" checksum="B5270ABAAFC95CD2" modified="2014-03-19" version="1">MPWDDWRKDFNKKLDDFGEDAKHKFRQQREANAGGSSSGKVGLQDRMNMLKGENPRWNRDVEARAGGEDHASTVVPERSRVPPTPPSALNKGRPPPPPQRGSHGGVTAAPAPALPPRMQNEDGTNHPPPPYPPAAHAFPASDGAGYIQFSKFSQEDKHAFFGLLDEYFEQRDYRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL34</accession>
    <name>W3VL34_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL34"/>
    <dbReference type="HOGENOM" id="CLU_020884_4_0_1"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF27">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="236"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="640" mass="69341" checksum="495650F68660149E" modified="2014-03-19" version="1">MEATSAEAPLAAEFKPHVPKDGLPPSHHVLAPAPGTTFSSYLPHWNAQPTLSAAQQDVESAQSAQVQNDSYDSNLTCLPSSIALVDSAKVVRIGFRNPWPSWHKPSLAEVWQGLEWGEDQDPAIDYALQDADVARNARTDLHQVESEAPYQDSRPGTPDQDGDRQPASSSLESRTISATQYTRSEKIKIASKQLLSVHEPSFDFDHTNDKLKATWLGHAGVLLQLAPLEPKQEPIRILFDPIFSQRCSPIQLAGPIRSYAAPCAISSLPPIDLVVISHNHYDHLDYDTIKELWAANKGRIRFVVPLGNKDWFVGASTFEQAEPETASTTSSSSYWTLAPSSVTTAATTSNLSILPDRVSELDWWDEILFSQPGSTGKQLRIVCTPAQHGSGRYGVDANCALWSSWFVEHPGVDGAPRPIRAFFGGDTGCQFHGRAFPPAPPRPTEEDFTLATPTSEASDGGSTLAEQVQAPTYRGGMRLQVPNDDEEYPACPAFEEIVARLGAPNFFMLPISVGATISFLRSYVPLPDSISPFPRLSAGLTAANHMPPWDAVGIFDKMTSAGVASGSSPADAVCLAIHWGTFISGPEEVLKTLGQLKWACHQHGIHFARDYNASLDPPSAKGRAGNKTFVALNHGASLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL60</accession>
    <name>W3VL60_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL60"/>
    <dbReference type="HOGENOM" id="CLU_1338014_0_0_1"/>
    <dbReference type="OrthoDB" id="10558936at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="205" mass="21602" checksum="4D630652B7604B2A" modified="2014-03-19" version="1">MEAGRSTTPLRGQGFVLALKLTIMIDATLERASTSIGDLNRIPPKAGPPDAKLSIAATQGSFRIDLFSGGGFGFLASVEDGKVSPSVVPFRVHLIPTGKEPWDKARAAGLDLLGPAAGASGIGGYNGRTEADAERRGREETDEAFAMLCLTDAPIPHACTHMQGSDEFGRVRCSLLAQLCNPVDALPFSPSDDRKSRSFLGLECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLA3</accession>
    <name>W3VLA3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_03061</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLA3"/>
    <dbReference type="HOGENOM" id="CLU_005507_1_0_1"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="320"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="609"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS62443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="844" mass="93696" checksum="926DECD2EC4D2438" modified="2014-03-19" version="1">MPMLLDIQRKLFAKSERVKSLDFHPTEPWLLAGLYSGSVNIWNYETGAIVKTFEVTNVPVRCVKFIARKNWFVAGSDDFQLRAFNYNTHEKVISFEAHPDYIRCLTVHPTGPYVLTGSDDMTIKMWDWDKGWRLMHTFEGHTHYIMNLCFNPKDSNTFASSSLDRTVKVWTLGSSVANFTLDAHDKGVNYVEYFHGGEKPYMLTVGDDRTVKIWDYLSKSCVQTLTGHTSNVSFAVFHPSLPLIISGSEDGTVKLWHSNTYRLESTLDYGLERVWCVAYKRSGNDVAIGYDEGAVVIKLGKEEPSVSMDAAGKVVWARNSEVLSANVGTTADDAVPDGQRLPVSVREMGSTEVYPQLLQHSPNGRFVTVCGDGEYIIYTALAWRNKAFGSGLGFAWASDSNTYAVHEGGAKLKVFRNFKERPGLLTLAYNVEAERPGLLTLAYNVEAVAGGALLAVLGGGFVCFYDWETGALVRRVDVEAKAIHWSTTGELVAIVCQDSFYVLRFDRDAYAAFLDTGAEVEDEGVETAFEVVTEVSESVRTAKWTGECLLYTNSTNRLQYLVGEQTHTITHSDHEIFLLGYIPQHGRVYVVNKDLAIFSYALSLALVEYQTAILRGDLDAAAELLEQVPADQRNRVARFLETQELKELALEVSTDAEHRFDLAISLDDFETALEIARSGPQVGSESRWRTIGDKALARWNVALAKECFEKAQDVSSMLLVATSTNDRAMLARLAELATAKGSTNVAFAALLSLGDVDACIDVLQKAGRTSEAALFARTYAPSKAGEVVQTWRDELKSANRHKQNEIAASLADPTRDEAAFEEGWKQSLEREAKLRAQTKVNGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLF4</accession>
    <name>W3VLF4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLF4"/>
    <dbReference type="HOGENOM" id="CLU_006504_7_2_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13886">
        <property type="entry name" value="CuRO_2_MCO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="74"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="148"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="246"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="544"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="76031" checksum="5D3E3E75DBF57BCB" modified="2014-03-19" version="1">MTSSNPIERVRLVGFATLALVLLAWGSLQWSALLRSSQPDAPTLPWWRHSHDASTIGDNDGRDAPRTRYHEWNISRADIAPDGVTRPMILVNGRFPGPHIQANVGDTLVVHVRNQLSHNDSSSFAGWDQRARSLFSTKVDDHYPPGSDERIAIHWHGLSMRGSPEQDGAPGFTSCATLPGESHTYRFRILPEDVGTHWWHSHAGMSRADGLWGTFTVLDPQQSERKRLAAHAAATGVAPLRWDHEQVVTLGDHYFAPGIDQISWFISRHSLGFEPTPDNILINGLGRVDCTKLLGLSKQECTTRSDYPAIALQRNKTHRLRIVNVGSVGHQTFSIDRHALTVIEADGSLIVPYNTTRLSVAPGQRYSVLVRAPQTGELGGSFWLRTEMHHECFNMPNPNLADEAKAIVRYVDEAPDAAAHAVWSSSELDLRDGQRRRGMQLGSRQALPQTQAWPLRGGELPCHDEPASLLRPLRVGDRADAPLTPRVDVENGDMRTAVTVTMPKLDRNGLVPVSWINRTQWKAPNSPLLHSFALQSHTASGADPVDPRRQTVLVPGTSEPVTLELVINNADEAAHPFHLHGHRFHVVALSESSVGVGAYQPHGPNDDAQWFNEAEAVYRDTVSVPRRGFAVLRWKLDNPGVWAMHCHVLVHMQTGMALAVVDQPHRIAQLDFARNLTTAAYPSADVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLT0</accession>
    <name>W3VLT0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLT0"/>
    <dbReference type="HOGENOM" id="CLU_1045849_0_0_1"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34812" checksum="1300BB5710CD9FA8" modified="2014-03-19" version="1">MGMNDDCEDGGADSAAATDDGEDQAKIRPASQPTPRTRLRSLQRCEPDAPSRFLRTLTHPQRKAFFFPQRCSHGATRLCLTVGGGPFKAKKIELWLELGRFFHPAETLVVQGSSARLQLRCSRATARKGLLLDRRSHQRHQRSSTSAMSSLWIINKAGGLIFQSEHFVHPNAASMPNGGRLSSNEYLVLAGTLHGIHAITAKLNPVPNRACSGIESLDSDHFTVRVMLTPTGKSDIFANPRQKPPNVLIPVHFMVVDLEGTKFVLVTSPAHPNPAGVLQRCYEAYADHVMKNPFYTPEMPVRVETFDKAVEALVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLU8</accession>
    <name>W3VLU8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLU8"/>
    <dbReference type="HOGENOM" id="CLU_495375_0_0_1"/>
    <dbReference type="OrthoDB" id="2549725at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="565" mass="62243" checksum="A379690044166904" modified="2014-03-19" version="1">MSSVNEKLARAREQDLRRARNLQAKLRRTCDGTDPDAAAEPDVPVQTVASSAASSSSRAGLMYISSTEQAQRERDQRSRETQLQRQVAGPIPPESWRGDFDRLTINRGLFIPGSKDISTTASASTLGAFPTKAQRKAICTVLRSVYDKSSPKPTATCVSDLFEMTLCVIADAINRPDSSHAHGKGKQRQARPEMDTEHVREVLSYLPRRMHQRMLALYGRVAATECPLADWTAQALTNQMQVEDHPAEGDWDEDGHSPPIDFSAALAPDLDGSFTALDLSFSSISTRTLSRLLSLGGGQAGVSLRMLSLAGWNSHSHSHLAPVPLDSPGLLSILSQLPNLEVLSVAGSRFFGHAPERTGRVDTQRTAMFLRRLSRSLTKLRVLDLSFCAWVCADEVQGVSWATPDAVAWPRLEHLLLVGCESFVESLDDIADATMPRRPSESYVGAWHATHSQRDLRETSAPRASAAHADSFDAAPTRPWIPPRLASFSQLITHTVKPNIATYIVPPPAAARQQGAMGEVVLCVFCPHSDERIEMWQWQRARVLDAVHGRTSSNARHRNWVDVWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM62</accession>
    <name>W3VM62_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM62"/>
    <dbReference type="HOGENOM" id="CLU_304051_0_0_1"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="978" mass="101773" checksum="D1507FCD026C9A1A" modified="2014-03-19" version="1">MASASAHPELSQPVSLLAHPSAAPAELARHAALPTTGFSSMKCSTISTGAAYKLSSDARTLRRLKGTLPILVAANALNLVNPQTQTPIQSFTLSSADTASSAPLTLLSSLGAGRSLRTTYVGIESHKRSKSGRATVAASHELWAFVEELSAKGKENAEVQFKKQVLPLDKPVRLIHPLSDGRLVLTHPDDSLTLVSSSPITFDDEASVESASTSMQVVQTIDATNGAGHQRSHFYVNILDAPSAKALVSHSSQIEEAALLGLRIAITSEYALANTSTKAGDDSKKKKRSKRSKKDASSKPSAKDAQDDDDDVAASSGHLPAKGAPSGALTLELTAFVKSFDGASDATAALVKLGRIEVPGISSARHVQDVHFHSAGRLALLGIDGRLTSFMLSTSSSAQPVLVRSGASVLPALAPASNARPSSSSTASPACCLLLSRDHALVVGVTRATPATQDKERIAALIVDVELGAVLREIDWAVPFVAPSSAAASSLGLLPRMTTISATRIAGSTSVITIGAPTVAARISDSSANAEALTQLQQRRLCVLSMPFVVPEASVLRDALGKGDLTARWIQTAATDAADAAGVSASDASRADVLDQIKRISQATGSAKAKGAEINTVISQWIEASTADGRMLETMSAPEADTTFFGELLDVLLPAQSSRKGSASALTASAALLTMLKHARVHPSVFASLQPTAGWTAANGAAAPPSNAARLSEFWSRIGSSNEPKLVRAAIERLPEVSEETLVSLLMTAVRGFSAASASKAAAGFMALLVELVEVPVSRAALRSALKTQLRDDVESVVALLQMCNAWISQTIQVPLQADERGDDGKMPKAGATMALATDVLDTFFPLLLTTPRTHATVEALSATIGRYVQLMSTLRLVNAPLSAFAKLQQENALLSEAASGDKRSNKRGTSLAASGAMASAGNAKVHASSKAEATARAEMGGGLGLKLGTMGEAKTRRLQLLEQSMLVGAYSFERLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM93</accession>
    <name>W3VM93_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04027</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM93"/>
    <dbReference type="HOGENOM" id="CLU_001499_4_0_1"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05499">
        <property type="entry name" value="Bromo_BDF1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="351"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="602"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="683"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="761" mass="81826" checksum="42828060AB75ACBC" modified="2014-03-19" version="1">MSDAFHSQQVNGHAFATSSNTELPPKTEASFNPPKLEHPHSTVVPPTAEPLSSVGIQPAGLLSEVQSHQPHTNDVPAAAAATTASAPHHPPPANSNNVDVKPYDGPIDVTPAQLKFAQSTLKSLKSRREAIAFLQPVDPVALGIPQYPDIITKPMDFGTIDIKLALTALVLRPNSKPGDKAKSAPQWGLDPAKDVYRRVQDFEADVRQVFFNCATFNGPDSPYTHNARVLEAAFDKYMKDLPAAAAVSAQSSDAGGARARRPSNPVPTIRRSSSDVGGRPKREIHPPPPKDLPWASEPQSASSSEQRKAARRKLAKKAGSLSAREQAHYAKVAQDELRFCTRVIDDLLKPTYSNVAWVFYDKPTMDFDWAPAYFQMIKKPIALRDVQKNVRSGVYADADEFNADMQLLFQNCFTFNPPGSDVHNMGEQLKSVYQDKMARKPAPAPLPDYEESDVDEDEDADEDEDEVDPEFLATLQAQISQLASTLAMLEGAKNQNADLIANTKAMLASLQESYASSGGSKKSKSKGGAGTKRKASEGGAAANRKKSKAKGASSPAAAASASAEYVPAKKAKAAGAGNKKKQAASSGSGSGSAKKATSSRRDDNSDEDIRTVTYEQKEELAAKITELSEERLDGAIRIINEDKPPNQNDEEEIELDIDELSAKTLYKLYKYVVRPKKVAAAVNKNSKSAPLDGRKRGTGGIKKKNLDEGEEAERIARLQQQLEQFGNPDAMGSGGGAAGGHDDLVHSESSSDESGSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM94</accession>
    <name>W3VM94_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM94"/>
    <dbReference type="HOGENOM" id="CLU_017928_0_0_1"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000844">
        <property type="entry name" value="Proteins containing the RNA recognition motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="336"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="714"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="79419" checksum="B381B6445FAE88C6" modified="2014-03-19" version="1">MLFDEAHTDDIKAWLTSELGPICDADPEVLADYVLALLKHEGPEEELQSMLTEQLEDFLAAETEPFVTKVFAALTDKSYLPQAQAQHAQESDNAQLAASESTSSLTADASRKRRADDDADASTRSPPRQSRRVHDSSAASEDPAARGRERDSRERHDNGDANGASGEGSRREPRKQLCRDYHNKGFCPRGDKCKFEHSSSVLPGAPNPRQQPAPYHLMGPGPGGPSNGMQGPPMMFQGAPYGMPPQGWHPSMGPAPGMPGGPTPPGAPSQTPGMNGDAQNLANRMGHPQQGPDAGGFAMGAPFNGPGGRGGGMGGRGRGRGGGPPGTFQSSRRSNTTLVIENVPADSLDLIKVNEYFKKFGTITNISIDQPGSKALVSYSQPGEAKAAHESPDVIFGNRFVKVYFQRLDEAAGTAPTPRPPPSAAGHAPGSHGAHRGGFVPGKSSNVYHARPPTGGAGAGAAAGGMSEERKKLFEDQRTKQAALDAQLAEQKSLLANFGNKDLSADDKKATMAKLKKLGEEIKASTEAVKAAVEALQAAPKDAGSSAGGDAGNWKAEKEKREKEQLDRELELHAKGTEAGSTTDELKKKLESLKAEAASLGIDGAQQYGYGGRGRGRGGFVPRGRGGYAPYARGGGTANRSLRIDNRTTRIKIESLPEGVDADKVRAHFAAFGELDSFDPAAATVVYKARNSAEQAIRAGAEIADVGAVKLSWIQPPPTEPVANNAPAADAEQQSTPREADDEDDRDSNWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMA3</accession>
    <name>W3VMA3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242105_0_0_1"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="7">
        <location>
            <begin position="825"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="6">
        <location>
            <begin position="1439"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="715"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1662" mass="184149" checksum="6CC9B40B4A3E62E3" modified="2014-03-19" version="1">MTAPVSTRPPARRLSRIIRCANSIKPEAKSQRRQPRPSHKSARVGSLVWLSSSSPAFSYLAALTAMPSTTTTEYEAIIVGGGPSGIAAACQMQRHLGLTKLLIFERGADFGGTWFHNVYPGAACDIPPRLYSFSFHQKKVWRHFMAKQAEMKTYLQDVARTYKLYPMARFGTQVEEAEWQEQHSHWKVTYRSITSGQVRTATARVLVNGSGALSVPRECDVDGHEQFKGPLFHSAKWDTSVNTRGKNVVVLGNGCSATQIVPSIAKQAKSVTQIVRAKHWYAPTPEDPFRSPAVRWLERNVPGFIQLERAIFTVVLDIHFLQAWNREGSAARQRFADNSTLYVSTVAPERYHHLLIPTQDELKVACKRRVFDDAYIPCLNMDNVDLTNDQAHRITQDEVVLKSGRRLPADVIVLASGFQAGDTAVQMKVTGRGGRELNDVWRKGGAPQAYRSTLVHDFPNFFLIWGPNSVTGHFSALYAIEASVRLMTTLLRPVFAGPRSMSPLQRSAGRTVDVKQEAQEKEDAMIRAQMHDLIYTSGCKGWYTNDQGRVSTLYPGFQLTFAWRSDHPVAADLAYTGVKGRPQAHWSWMQQLSSWLRLGDVPEYRRERLQKRAWWNKALVDPVWRLIGSLGVRWLLGVVWLLDRAMMYTRGRAQFEEGVVKAVRSGDVSEVNSADMASAWLRVRQARSVQRRTPLKATHATRLGLAFEAEAGTANTATLPPEPDQGASPRASQPALGHQSHSSSRRDGWCQGALRRDSANASPSPIYALDPAAGGGRTLSPLNDTMTAPAGFHLIPSHVDADVPLRDQEVHLVLPNHAHAEHRYDLEAIQAFQSAADYLAVAQIYLLDNVLLHTGLDCEAHVKKRLLGHFGTVPGLVFAYAHATALLARTEKKATAAGDEYQPRGIFVTGPGHGAPAVLACLYLEGSISKFSPDEALSAAGVQRFVKNFCWPNSMRPSHVTATTPGSIHEGGELGYALGVAYGAVMDKRDLIAFAVIGDGEAETGPTATAWHAHKFIDPAESGAVLPILHLNRFKISEKTIFGAMDRSELLALFTGYGYQVRFVDYYQHLGGRHTRPGEREVAAFDVDMATSLDWAYDEICKIQRAARNAEPVHKPRWPMIILSSPKGWGGPQTVDGLQVEASFRSHQVPLHVDAHSPPDRIKKLEDWLRSYQPQMWFALAGEGADRLEMSSVVTRMLPSESLRMGQLRELTQRSPDLVDVGTGGFMVDSETSAADKKVQVSAMQQCGAYLAALIPLNPDRLLIFSPDELVSNKLDAALSLADFKGRKFEHVFESQVTGTERRQGMRSGRVIEMLSEHTLQAFAQGYALTGRIGVFPSYEAFLGIVTTMISQFAKFVKEARATGWRSPVPSITYLETSTLWRQESNGFSHQSPGLINAVLDLPHNVARVYLPPDANCALSTLSHCVRSRHYVNLVVGSKHPNRVFLGADEANRHCKAGASIWHAYSNDKLGNPDVVIVGIGTETTAEAIAATELLKGLGGKESIRARFVNVTDLMVLSERSVHPHALDAWSFQALFTTEAPVLFNFHGYPTAVKGLLGDRLSDVWGRRPTAVLGYREQGTTTTPFSMLMLNGVDRFTVALTALDLLIHKHDLKEDWRRVDARLLRMVVSDEFVELQTSLQETRQKWQTYIDEHGCDPPELDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMC3</accession>
    <name>W3VMC3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMC3"/>
    <dbReference type="MEROPS" id="M67.A10"/>
    <dbReference type="HOGENOM" id="CLU_052991_0_1_1"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="311" mass="34507" checksum="06AB78392F6222A2" modified="2014-03-19" version="1">MDFQSMMQQARMGGGPGAGGSPGDAPQNDNAEMVYISSLALIKMLKHGRAGVPMEVMGLMLGSFIDDYTVSVIDVFAMPQSGTGVSVEAVDPVFQTKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSNVDINTQQSFEQLNPRAVAVVVDPIQSVKGKVVIDAFRLINPSTVMLGQEPRQTTSNIGHLNKPSIQSLIHGLNRHYYSIAIGYRKTELEQSMLNNLHKRNWTEGLRLRDFGEHKQNNQKAIERMLSLSEAYNKSVQEESTLTPEQLKTRHVGKQDPKRHLEDAVESTMGDQIVQSLGTMLLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMV1</accession>
    <name>W3VMV1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMV1"/>
    <dbReference type="HOGENOM" id="CLU_009770_0_0_1"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="546"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="686"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="748"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="787"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="880" mass="93448" checksum="66276CFA32ED0C5E" modified="2014-03-19" version="1">MAKKQAVKPSRSRPASTSELNQPLLPSSGAVTASTASCSFSPAPDHTLFAHISNQVHQQRLRIYNASASAASTSQLVTDFLLASLGGAECLSSQWVRISTSNKSTKRRKHGAENGADATPASSSSSQLLLALGLSSGQVHLLSPALAQSVAILDASAASGSSTSSAANASVVSMSFSDDKATLFACSKSGWVSAFALADVKLGDQQAPLRPFSSFRPDTKSAVQLLASRRDLVLSAHHAISLTDASQSDNAVRASFTGHASPVTHLEWLSDNSFISAAEGDRIVSAWSFDDSKTGKSVTGHAFATAALDGPVRALSVCAASTQQPRTLITIVTQTGSVRIYGLPAESKSDASPSKKKSAALPSLELLAQSEPSASATEWIDSRIVADKLRLARLIRGAKVSIDETTIMRGKDAQLQKTLQMPVTGAKQNASSSGLLVADSNEAQLTGGAASTQRYADAPMRPQGMDDDGLATGLEDAGLVATPSSRGAELEPTLAQRLKELGFSDPSTAGQEAEEDDAQMPSKKQQSLTNEASLASSLSQALHSGDTSLLTSCLNHNDPILIRNTVRKISGPLSVKLLEECVSRLNGVGGNHVSKGSMGSQKARGLMEWVRATLLNHMGYLMSLPNLVSRLSGLHATLTTRLATHERLLALNGRLELVLSQIEARAAYMSQASNNQVRVQGVKFGKKTQGDKLAQAQSEDKQRRKGKKWVEETDDSDSDADDMATDADGVLVRGENDEEGDVQDIALGAESDEDDDEDSDDEDAGPLRRRRRVKNGRASDGNTSAESDSDADDDDDEDIEDIEDVDDDEDEEEDDDEEEDEDEDEDDEELPDESDLEGDGASDMEDDDDEEEYDVEDGGRGPNGMFDLEAEEGTDEDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMX0</accession>
    <name>W3VMX0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMX0"/>
    <dbReference type="HOGENOM" id="CLU_290346_0_0_1"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="886" mass="94756" checksum="09FE209D86382652" modified="2014-03-19" version="1">MPPKIRQRGKKPSKLRKLQEDEAESKQEQPVASTSNQIQTQADYIALDNTTTAADASSQQPQQEDGQPNWVRLGERSSKAEHEAPFGYVDAELKAYLRAGWERATELETQGYSAKSTMTALAAASSGGSDATHPAGNGDEEQEEDELALLLQATLKEMDGKELLLSTDPDTSLIVEAILHRLPAKPLRVFVDRLAGNFAVLSKHRFASHVVQACLATLQPAVTLEPATQQHLSQHQHRNGSATNGKAAASSAFASDTATIVNEDGVLRSATQLILDIAEELASDQAQLAALVSDAFGSHVLRSLLCVLMGRNIQMDTSSSAHAAAAADLRSRRSAKFRTRKAPTSVAGSGAEDLLVVIPDLLYTRAATLRSEILGEAGTDVVRRWAADAVASPLLQLLIDAEVDALGDAADEGEWSGSLVDLFLGGFVSKPPTTGEGEAERDAYLETSLRDSVASHALQLALERAPAATAARFFAVYIHGRMAKLCIHPAANHIVAALLRRLSAAELAPAIAEMGKVATGMVKEQMIGCLQAAVERVGQLCDPAAAVEGDGARELVKAVSGVVLGAFRLKAKAEGEEGMELLVPAVLALKTRKAYLHTFAAHLKHDEAADQAGKKRGRDGKPLSKSKAKSKAKYAKVREAQAESDEGQVAWTIDAEYEVPPAEATVQGSLLLQSLLRLPGPSVPPRGPVKRTFGRPTAAAPVERVEVFGSALVLESLLALPTLAPFARNPTAVHTLIAALTPPTTPATTGLDAAQANRRRKLGGALVAQLAHFCGDKYGSRLADQLWYTSDGYSKEKIAKTVVENSDTILRGAYAGYFTNKLQLQLFRKGKMREWTQAIQSQPPPRKEAQQTVVEKQSPIVVATSRKDKSTKRKIDGQLDAILDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN65</accession>
    <name>W3VN65_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN65"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="101"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="601" mass="63717" checksum="C35C021658826C4B" modified="2014-03-19" version="1">MAPTQSERTPLLGTQQRQPSVSRHRPSFAASIGRPDLTAEEEDAIAQESAFSAIQGAAHGVDPNSSAFVPLDQSHFSVSGIGGAIAEEPEEPPLRADIWVIMGAMWIGSFLAALDGTIVATIMNSVGSEFRVSKEVGWLGTSYLLTQTAFQPLYGRASDIFGRKAATLFASVIFLIGSLLCGLSQTFWQLCAARAIAGIGGGGLTTMATLVTSDLVSLKARGTWQGLGNLVYATGAALGGPLGGALADGGLGWRWAFLVQVPLCAVHFAVVSWKIDIPAGPGSMIEKIKRIDALGSLSLVTSVTLILVGLSLGGNEREWTDKLVLGSLIGGGAVLVLFVLIERYVAREPLMPMSVLFNRTPGFVAIACWFITMSQFGIIFNVPTYFQSVEQTASSYAGLHLIPNAIIASSCSLGSGLIMARTGRYRKMLLLGGLFGFLGPLMMCFWHRGTSEVFYWATMPFGGAAYGSILTITLVALIASVDPKDMAAATGVTYLFRATGSVLGISLSSAILQNSLQKNLEKTDIPRKVIQLIRQDAGAIKELSKPLRQAAIGAYEQSMHTVFIAIAAAGFFAFLALFFIEERDLPGKKPAAPAAPARAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNE0</accession>
    <name>W3VNE0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNE0"/>
    <dbReference type="HOGENOM" id="CLU_048015_0_0_1"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051078">
        <property type="entry name" value="SGF11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46367:SF1">
        <property type="entry name" value="ATAXIN-7-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="441" mass="45407" checksum="CDC103B4BD7512C8" modified="2014-03-19" version="1">MTNDPKALIAAKFLDSFLREIVLDTAIHTHAKIKRARSICKLCGVRCQAHTPAAEQTATLSAAPGTAETTTPTSRSGTPVPGASSSKPDYYSNNPLFECLVCSRQVSSNRYATHLAKCMGMGSKGGRKGAARNAKATTSATMSSRQSGAATPRYGSDLDDDSFAKHKNGKNGTKRANSPLAASSVANARMNKRIKTSSPTPPPTDSLATATGGLNRSYSSQTFAPSGLSNSTVLTGSPLNPNNTPSTAKPLSASKSNGGTPKPFNGKASGANKRKRLIEDEDDDDEDDDDGGGSYAAGSDGSGSGADTNAAEEEGEISDDDDDVALAAGGSARPANGAGGKIKLGSSSASKPRTFAMVIDSDDDSDTSLSQQRKSHAVSDDDEDDDDDVQVTGVHRGSAAGRAGVKKKSTHGSSGLQRERGSDGEFIDVESASEQSDADSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNZ4</accession>
    <name>W3VNZ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNZ4"/>
    <dbReference type="HOGENOM" id="CLU_110343_1_1_1"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="145" mass="16034" checksum="8C877ECF94F53CE0" modified="2014-03-19" version="1">MSDVEEVPQEVQEVEVADAPAAKGAMSIEDALQEVLKKALIHDGLARGLRECAKALDRRQAHLCVLVETCNEPEYLKLIEALCNEHKIDLLKVSDPKTLGTWAGLCKIDREGNPRKVVGCSCVVVKNYGEESEGLNVLLEYFKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPB7</accession>
    <name>W3VPB7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03257</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPB7"/>
    <dbReference type="HOGENOM" id="CLU_030949_1_1_1"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="373"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="482" mass="53723" checksum="A8FBE272A74AA95B" modified="2014-03-19" version="1">MASFESWQSPLSARYASKEMSGLFSNATRFSTWRELWLNLAIAERELGLDISQEAIEQMKANLTLDERQMALAAEEEKRRRHDVMAHVHVFGLVAPEAAGVIHLGATSCYVTDNADLIFLRKGLDLLLPKLALVIERLAAFAEKHKALPTLGFTHMQPAQLTTVGKRATLWIQELLWDLRNIQRARDDLGFRGVKGTTGTQASFLALFDGDHAKVEALDERVTELFGFPHAMPVTGQTYSRKVDIDVLNSLSSFSASALKMATDIRLLCHLKEVEEPFEKDQIGSSAMAYKRNPMRSERVCGLARWLGNAVNSARETAGAQWMERTLDDSANRRLSIPEAFLTADVILTILQNVSEGLVVYPAIIARRIQSELPFMATENVIMAMVRAGGDRQECHERIRVLSHQAAAEVKEHGRENDLIARIKADAYFAPIIPQMDQLLDPKSFTGRAEQQVDSFLAKWVRPAIEPYQAAIQGAGKAELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPN3</accession>
    <name>W3VPN3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPN3"/>
    <dbReference type="HOGENOM" id="CLU_296693_0_0_1"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF3">
        <property type="entry name" value="PROTEIN RDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1015" mass="111382" checksum="7C249D17DE23D006" modified="2014-03-19" version="1">MSSLVESTMEDASTDASGNKRKRIWAACEPCRKRKSKCDGQNPCSGCVSTIKTAMLPINATTLQNGTIDEALVQAKAQELCVFDWNRKPRGPKGKKAAFAAAFGAESTGSVGAPRSHTSAGPAYMEAQKRTLNETQHLNSAPHLPNYDPAFTFSSLDSLSAASSSTTSPALAPPWPEMHPPPIVENGGPHYEHHVPTSAMHPTSMANGVHAAQASSSHGRPELYQRGSNESSSLSDFSSHTFAGRHSESNTSLSTFSPPMAPGPSSRPMGTEERPLKQAAYDYFGSADNRISKASLSAWDALADGASHPRSNSVSSLLRSQNSAGTSPTEVNRHGASPSHSQGSGSLPAGASPQSDGSVNYFNAATKLSSAEADNCDTRYHDQSMLINRLKPYYSEKDRPFVALAISQFEALDSFEKMIPSRYLFGSSPGSSGRDPPAHVLLALLAFLAHRALLLPDSMNIEDLDLQAGDLVLRCANNYGRLEGDDRKQMLSFARRSWTLANDLMLQKIRSGDVDPRLIITGMLLEMGAGEDGLSSKGLVQRKMWLFRLAYCWRLHQLDAKPDSESWNTAWDGREVLQKAIEISGATSADDPRAPLPRAADTRSMIKDPIELEAIRRQVSLIFTAAYWVQTADLQVPKFDVYTMELEPAGADDFIHHGSNWTPKVHPASNGYLTQTRDLIFRTYGRLTRLLHTPLADICTGHSPEPDLQHAITEMETTLDWLMERIGSVTYEGPEMPLRVAAFVHSRIVALLMYRLFISIQAFFFLFPERTTAKTDKSLRIASTLMPKGEARSNFEMIAGGSMAPESESEDDGVAGRDFQGRRLLPRPQFTRHPMKASMAVLWETGGVAKRLLDLHRARDAALEPVEGPSASALRAGEGEKEKTGNEVGKTMDASLRAVRWPRHLRLFAQHAYAMAAEAHVAGASWLDTYGDENPSWKTPATFELLPEFNNEHIESGLWDTGDAFLELLEAMAKMGSTHARSNEEATLRYRQERWNWAKRYQQPPSGLTSMPIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPR2</accession>
    <name>W3VPR2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPR2"/>
    <dbReference type="HOGENOM" id="CLU_002974_0_0_1"/>
    <dbReference type="OrthoDB" id="2553354at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1253" mass="133452" checksum="84EE5870A7603D7E" modified="2014-03-19" version="1">MPPLRDASSALNKPSPPLAVISADWKDPQADRPPSPKQKSHACVASDQAALIASADDQASTGANIAKTTNDISAFAFPSRGSDAGASAQPELNVPNTLRQRQAKHSTSRSLPLATLAASSASSPMPTPPSTASGDASASAATAAPQRRPSRLGRSLSHRKSSKSLSMIGSMFGSAAHAHHASSSPPLPQSAAALVQESPAPTSNHTRKPSLRGLLKMGRSATEHNMPRPSTPEIESWKRANEVASSPFAETWRRGRASMDAPRRPTPAEVPVKITRSKSVIRRKPAPEVRQEEIDSSSSTPVHGRTFRALEVDPTAASPLGGSLASSPAQQHAELANTSADSKLSASFALATQKVASKQVEANSNRGLGLFVDPFASTRKDASLPSIDVRPSTPKQTDAQTGQHQNQHKLGATTSPSNADKRLSSSAHSVTDTSLSVERPWSLISAGDADTPLLKLRKLVVNTESSDESRELDDVDGLFFRPPRSSARAADQPDKAEQEFVKSEIEVDQPRSSSQTTTRSDTKHEIASIHSSGSSTLRPVRDLVERGSISGLSAASATVSDASQANTIRASSLAEPEADSVGPLPAKSPAVSQHSGRRQHRRDGSTGSAYSQATVQQGRRASTASRLTARSSGHWSESRVSEDALSALEAEVGQARRAEVVALGKGRVRDWVGGGGAEMLPTADAPTLSRTNTLRKKPQPADRAAPVEASAAKVDEREAQRQKTLNDHLSRRLQQLSDEQDAPVLSSDAEIRDIPDLDSRDEATQPAEKPADEPRFGAPRFARLSAFHDRKLMPDVERSAAPAGVAPTATTIQTADEAIRLGRAPSKRVRRTASEAKSCGEAVMVSRAPVVSSAHRRASTTSGGSGMLSARHRRRTNSLSAKRVASSGEWNPTLVAEMPVAASAPMVEFTGLPAAVASVDSQPERAEEVQESGEKKRTKQRSYATSEEAARARQQELVEREQRQADKEARRQAHLQHKYAKKKQSDPLLAARLALAGLQPVEAVPRMPSTQTVGRAAAVKTTLFGMGLQVPEPSGRRSSLAASVSSFHTAVDGMGGEVAAVSPKLGSGSGEVRPDTSYSIASSLAVDFEFPVPPQRMKEQLSDDGTLLSRAGLQESPLQQQWRERRHFAVGTPQVPTPPRDSSLRHRQGSSRSSRMPSPVETQEAGGMSASRTMPRLSAVSPLESLGQNVALRRSRSVGYNSRDLRRITREQMARDAERHPSPKSQPKPLPDGGEQGLGIQLDEAAQRQPILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ20</accession>
    <name>W3VQ20_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM50A/XAP5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ20"/>
    <dbReference type="HOGENOM" id="CLU_037985_1_0_1"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="261"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="403" mass="46786" checksum="05D028A58DA3C41F" modified="2014-03-19" version="1">MQLLLHTALADLRPANVLETPPLAHLPPTHIHSLTRSQASYRASYLPLSNVGLPVLASRYTARIAGMSQSQAELRRQGKHEKARAKMMEDFERQKADLIKEAERNRTGADRFVGKNDTMEDALKKSTIGLVHLEDFQKLRSELEEEKRREAAQTNELKADDRAAKKKKSARKERSKLSFALDEEEEDIAASIPTKTNRKRPSNDDGDEEAEIVAIPKKTSLKNPNVDTSFLPDRDREEAERRMREELRQEWLRKQEEMKKEDVEITYSYWDGTGHRKTVMCKKGDTIAHFLEKCRQQVTELRGISVDSMMYIKEDLIIPHHYSFYDFIVNKARGKSGPLFNFDVHDDVRLIADASVEKDESHAGKVVERSFYNRNKHVWPYSRWEVYDPKKEYGSYTIHDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ39</accession>
    <name>W3VQ39_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ39"/>
    <dbReference type="HOGENOM" id="CLU_316678_0_0_1"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="701"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="984" mass="107637" checksum="46C3D135C9C5248E" modified="2014-03-19" version="1">MPSKRRRPALDSPAQNHASSSSSSSSAQVNGFVLATPMDHRVLVQTEQQSPSFFQRVAHYARLFTPSRKRPRIDSASSSLLDASPSARIPASNDTSEASASGFVELTPSRSTQSSALASASPADKLAAHLIFPQEGAIRDPLGRASVGSPLGTRSVSITDTRSSSEEAAEMQIEAPSSPSSPSPPTNADLSPLLIESRNNDGEQHADDQDAAQSSSAALPSSPLGPLPPTPSTDTSSRLALQPVDYKNTSQQPALQPDSPKPSSEADPSPSATAETDDMAASDAHLHSSSSVHDDFKSSSADAALPTDADVDHIQAISTAKVGDNIEGLLTWSAPLTTQDVEPPSASPSESADSASSTAESETRQDPRPVAANNVVDMTCLSDDSSSSDDDDPDKENDISLVQPSPQLTSAATLTSFDNFTPSQPAFRAPQSRHSFGGPLTQAALREQRSAAHHSSQFATTFGAAQDGSADGSATEQIRSIGLQSIGRQTSFVQPARHRLPQASTPRQDISSPGLHRSMSIDSTASSLASDATAHRKRRSSGIGFAKRTHIFQKQHAQVVSAYNLEAIKASLKKINLMRTSQRKTLLTPEQFVGLAAKRRQVQKFIDGENRHPTSRDDSIEILMRKFMRQKQIDAQSAVLPVSRPRLVQMERLARERRAQAKKLRGVLGRQALPAQLTEEQDKMASAALSKRGQIAAIPGAQVEDRDVEKLRPRQWLNDEVINFYGNLILQRANDADKRRTEAIKAAGSDASPVAEKPLVGKSARAGGKPQPKRPYDAALDAFWRVHFFSSFFWENLKNRGFDGVKRWTRRIDIFTKDLVLFPINLGNSHWVCGAINLRRRRFEYYDSLGTRNPRAFELMRTYLAEEAKDKKKKHIDLRGWRDVFSDESPQQENGYDCGVFAAQTLEQISRRDPHTPIPLDPPTIPWMSDDIETDAGRMKITSADDAEDDDDDVDEYEWNFGQENMPYLRRRMVYEIASQRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ64</accession>
    <name>W3VQ64_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ64"/>
    <dbReference type="HOGENOM" id="CLU_010246_4_2_1"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="506"/>
            <end position="510"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="787" mass="84498" checksum="A8B9A9E98BE410FF" modified="2014-03-19" version="1">MKGPQGTRQNGKAAQVSRAKNVARGAIGCRQRRGQERAATRLQLPLSVRTSKIRENASWICANRPLPEAEAEARRSQHALTQEEITARDAPHHHSASRPIAPPAVLQPSRTQREACGGWQQLTASGLAHDSPNRCVPSMSYSDSAAARRDPPSSGKKHYRAKSISRSSVDLDNSETGALLLAPNGLTSEADDHLGYPPHSGSAGPAGAPSRSCSPRRMPLGSRRLALILFGFVGLLVLFGRRDSRDAVVGYAKDKAGQVGSAYQHAPWKAQPTQDSNNAVGFPVAPTPASTPAAAPVSGTKADTVRQKPALHPDPSKTTRCDGTGPRPVDHNGRPRPLVQYALMIDAGSTGSRIHVYRFNYCSESPELEDEYFEMLKGGLSNYGANPAAAADSLRPLLKSALQRVPANLRKCTPVAVKATAGLRLLPGKQAEDVLKAVRHMLEFEYPFPIADGRNADGTKASKGVEIMDGKDEGVFAWITVNYLLNRIGSSSADKLETAAVMDLGGGSTQIVFEPSFTSALQGMQPGEHVYQLNAFGTKPYTLYQNSYLGYGLMQARMSINSLAAFTFSLAHPNAVLTGSAHDGAQGGFEWSTLKPDNTRIPSPCFTNGRTKAVLISQPGQRTQANVTMVGTDGGFAACRRLVEVMMDKDAVCSSKPCSFAGVYQPSMMETFKTAPIIALSYFYDRLEPLGLAPKFKISELEAVAQRACAYTRTSTQGFGARAIEELEDRPETCLDLSFMHGLLSLGYELEQSREISVAKKLGGTELGWCLGAQLAVLDEDGLICKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQG1</accession>
    <name>W3VQG1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Antiviral protein SKI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001688_1_0_1"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="762"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="837"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1597" mass="174840" checksum="190A1838D6498699" modified="2014-03-19" version="1">MGEAVIERKMKQRGYCSILVGAAAATQSGGSAAAAMSSAYAKQKLKQSRDALAKKDWPAAADAATSVLEQEADNYNANVFLGLALLNQGKFDESEAAYIKATRDQPTQLLAWQGLQKFYDQRKSWDKLRDVLHQLLDLYNDAGDAIKCAETLQRLLALEREEGGRKLVIDTLSLLLPDSKYYDTLSSLEQPDQTQPEKTTTFEMQMAIHVNSLDVLLEMSELSEKWEADTIQKEADKRRMRLAGASKGKEALTNEVRLEVYSASRLPSLYEQILSHPKAADELRIEVEAKLLRHRLGLLTSFPPKQLNAGAAPTGTAAVDAKQQERQRQDEQDRQDAKVQLRDEILKLASGMVIIGLPDELAWEIDLEWRPVRSLVDLRHEQIRKFVSLFPRSGRTKAFRSFLLWIKDEQFLNEIKEEEKRTDSEIQQPQSQDDLLNLAIDGLEECPDSVLSHRIAATFYLLDRDFQSATEVANSALRVVSRIENDSAVDLADSQLGISQLLLTALTHLHPPQHHARSSRLIDGVLEKDPSHIDTLLARAYIDQSASRWESARGVFEKVRSIAASLNANDYRNRIERLLSLSPDPDQEAWIEMAWCDVNLGNLERAKSEMDTILERLDPISFQGATAELRAKLWWRLGQCLWLMDGEFRANPDHAFTAFITALKRNPAFAPAYTSLGLYYGDILQPPDLVRSSKCFQKAFELDAREDVAARRLAEGFAEEQEWDLVEVVARRTIEGEGGADAIGSGTAAAVQASRRHLSRNAWAWKAIGNVEIAKKQFEDAIMAFQIALRAEPDDQISWQRLGQAYALAGRHVAALKCFAKCLDIVRAAGDPSDDGWQAQYSIGQVHLELGNFSTAIDTFASILQVHPDELGVKVALSNAWLLSSRHELATGYVERAEISAYSAIRTSLKALLQHDRHLRSAWKIVADAVFHLSNFGKLHQAALLEEVGLGGLKPLLKLAAELETDAKLPSISIVTHEKLAGAVEGLSPFRLLNISVYLYKLRVVLNASDENVAGSAWADLATALYRLSRAMLLPSSQAGLVATETLSVAEVAEAQSVQARLQAIGSIKEALRHEPGQEAYWLLLGNLTFHSSVDLAQHCFIRAIENAPKSAIGWTNLGLLYLHHCDVELANESLIKAQTADPDYGPAWVGQALVAKHYGDHRASRVLLEHAVTLTEGSVQEADYGLGESVFDAFRRHAATNAADARITEATLSNASFALSSYIAHSPSDVDALHLSALVSERLGQLDLAIDRISAAATLLEERYEATESAVVARQYAVAESNLGRIRLAAGDFDGAAAAFEAAIGLLDVADDEAIDDAEDGKIEPQVLEIAKVQSQLGLALAQHFGGHNDNALGSIRDALSNARAAGAVALERDLTLQLAKLLWAVNGSAGIEEVKQELFGNIGADDNSSTHVPSILALAVLGLGSDDADLAEAAQAELEAVLQSAGADETEAVDDVVRVLVAIKDSGAAGGADALTLVHEAIQAALARRDRDQRALFSLHLVYLSHAVRLLERSGKEGMGEDQISQLLAYASLTQERFEESAPLFSEIEKKRSGLAKIQAQLLKHFPTELASSVPHPEHTLVALAKLDAPWSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQJ2</accession>
    <name>W3VQJ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQJ2"/>
    <dbReference type="HOGENOM" id="CLU_410030_0_0_1"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="297"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="725" mass="79930" checksum="3A86D28FFC4996DE" modified="2014-03-19" version="1">MSYTGHQSRTSSSSNLNSRPYASSSSHGVVANDDTELAFAELQMLSQNQRKLATLTSRMTTILSGFDKRLIKLEGSILPIHKGTQKLARMSDNIDLTLAALNKTLGHYDVVIDEQPLLKQGPDVRDTRPYMDTIDRVIKGLQYLQKSDLKSQEGVMKRMNDLVELGARNLTNVISEWVRADSEVIDLSDYSPRNARYPVLSEATHNAIVPIFNYLSTLPRHPRTGYSPLSAGFAAYATVRGNYLTHCLTPLASKLQQYALERIGTGASGAGMVMVAHEDDEDHSTGYRRGEAGAVEMFEAYYSMLDNEYRILQGLVSSAELHKETLLLASAFSQLVSASLSALIESLSTIHSHVRRHLATHTSFLLDLISALSAVILSGRWDVLIRSMEDSPEAPLSSNCPIDKADLDLNAGFAPAAELLEIFSKLKNVAIGIFPRFIEDVKAIPPRKAAEVPSTSVNEITYLGLQFMRQVTEYSDVVSPLLQTLGNGNWMMASGVAPVLSLGLDSDPSSQSIVGDYLNDVLAVILTSLEARSRAIRQPSTASVFLLNNIGHLRRTLMAPLPNYLGAAEDGGSASIVSLHLGEMGDDLLGTALRQANTAYLDAWSPVVAPLMEDQPLNANAHYHRHATSKLIGVGSGSEKNQVKDRFARFYEALDDLERLHRAYPVSREDHELKDRLRRDVIRLVVPMYARFLGKHKAGDFTKNPSKHIRMSEQEVEDKIASLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQT0</accession>
    <name>W3VQT0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQT0"/>
    <dbReference type="HOGENOM" id="CLU_017006_1_0_1"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="394"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="688" mass="74697" checksum="4600D46EE5094BE0" modified="2014-03-19" version="1">MPHEWHAGELYIQSQLGYKDAVAGAHPTFKPQLTVQHQQFHARLNILPVCTLDARGRPWGSFLAAKDGQHGFISSPSLTTLIASQMKLHEHHPVEMALTEGAKFGMTKLVTNDDGDYQGPALKLIAGVGVMFENRRRNKLAGFINERNTGSREERTIQVEVMESLGNCPKYINSRSLVPNPNHSPKMLHKNLDLAPGQSLPEETLQNIARADAVFLATRYTSPVQTIFKSHLGINIRGGKPGFVRISAEKVARSSGETELRQVAYLPDYSGNRFMSSLGNVHSDKVAGITIPLMRKGQPIDVVYLTGDAEVLIGEQSTSIFPGVRTCVRIELTGFMHVQDAVPLMPDDFDPSQGVEDFEHKGDDGIGWSPYNPPVRRLRSELSSAPDNSSDQQSAGNHASITAFEQHTPDLATISFKLSQPVRYRAGQHIILDCGSLLDAEVKEYKHMSDKFGGEQELNDTGMRTWTISSAPTSPSSPQDTVSITMRRVDKGLVTPKIFAIARQASAGKSAGELPVLGLGGDFVLPTKLEAQTKLLWIASGVGITPFLSFLASLRASTESVKIDLTMILAVRRAEAVAMLTLVRQALESGPSSSFLNGTLNLHVVSAGVQDSDLGASTTVGGLQVSVTKHSQRLDPELLLFISGTEAEGADKPEAWVCGPASLEAVVMQTLQDAGWPADKLHRESFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR52</accession>
    <name>W3VR52_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR52"/>
    <dbReference type="HOGENOM" id="CLU_160160_0_0_1"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="61"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="129" mass="14392" checksum="1EF42952645451A8" modified="2014-03-19" version="1">MTKAAAPLHLAVRNAKNPRPESEASIKLLPAFQTSYRFSTPHRLAKMSGLADADQKELQTFLDAEQAKARVQSSIHTFTDRCWDQCIKSSIGSSFGRGEEACLSNCVERFLDTSLFIVNKLQEQRGQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRB5</accession>
    <name>W3VRB5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRB5"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF81">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="55"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="604" mass="65543" checksum="318113003D212088" modified="2014-03-19" version="1">MTRATSEGSSTPSKQEDNFAAATNAHLAVDKTTKRRFGPSAIAEDLRDHWRVYILGICASFGGLLFGWDTGLIGGVLNMPAFKKDFGLENNDAKLAALKGNIVSVLQAGCFFGAAASFYLPHRFGRKQAMLISATVFLIGSVIQTVCRLNGQSANAALNQLYVGRVIGGFGVGLASSVVPMYLSECAPRAIRGRLAGMYQLLIVTGICIAYFVNYGMVQNYPDQTSSAMWQVPFALQCLPGVLFVVTLLFQPESPRWLVEQNRIAEAQNSLARINRADESDPVVVGILTEIQQDLQGKSGLSLVQQLKMAFSDRVITYRVFIGALLMFFQQFTGTNSINYYSPQIFKSLGITGQSSGLLATGVYGVVKIITTGLFMAVAIEQLGRKWCLIIGGLVQVFTLFWIAIYQAVRPAGTPVDGVGYLTIAMVYIFVVGYGLGWSSVTWAVSAEVAPNQLRALAMSAATMSQWFFNFVIALITPRALEHIKYGTFLLFGIMTSVAVIWAAFFLPESSGVTLELMHRIFEGNIIARSVQDLSPAKRKVFRARLLAEVGGTADDGMVTESARANEPAFATLDREESYAAKKADDDVVKTADAGDSDADHARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRG7</accession>
    <name>W3VRG7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRG7"/>
    <dbReference type="HOGENOM" id="CLU_024204_1_1_1"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="115"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="587" mass="62238" checksum="CB8F2E64A5DE8196" modified="2014-03-19" version="1">MTIEDEKAVRGDMSRSSPSSSNASKTDLEITEAIAAPVSEHAGMATMLRMGTNTGGVVTSEEYMTEDEKAAKALKDFGYHGFQWSSLWRPAEINPLNGKSYTFPIFRILDVYSTSFWLATLGFFVAFLSWFAFSPLVPEAVKADLKLTSVQVTHSNMASLGGTAIVRIIAGPACDRFGPRKVMAALLVLGAIPSGLAAVVKTSEGLYAVRFFISILGATFVTCQAWVSTFFDKSIVGTANAFSGGWGNMGGGVTTAAMIGLFERYRKAGLSSHLAWRVCFPTLPVPCLLLVAAAILMFGKDHPAGKWSQRHMFSGTAVAIAQGEHVELDASERAEYARTTADNEKAPAKGANFREADPADAGKRVATVDTAQSEPLTLARLAVILADPRVWMCIMCYLLTFGLETAMDAALPGLITTLFQSKTFTAIDAAYAASMYGLLNLYARPLGGVVSDILFSKYGLRGRVIWLLVTAFSQGVAMIGMGVYCNRDPTLGGVLAFIFLIGTTGFLANGANYGIPAIICPSAIGTVSGLVGAGGNLGGLLYLGIFLAVPGVRAKKTLGTKFWIAGVVNAGAVLPFFLVLLPGKYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRJ3</accession>
    <name>W3VRJ3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRJ3"/>
    <dbReference type="HOGENOM" id="CLU_1441634_0_0_1"/>
    <dbReference type="OrthoDB" id="3348033at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="160" mass="16453" checksum="82A4B35301BE0CDD" modified="2014-03-19" version="1">MTANTNSLPAPGGARKAATRGPNGASALASELGAARDVDRDVARARSEGDKMPPSNDASRVLEFGMPNGAEQGVETPGREKRTELQNMRNQELGRDQPDLGKIAQTSAGTTFPTTNTAKSTAANDPDALLDTVARSTGTESGTSSANTAVQVTRDAPTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRX8</accession>
    <name>W3VRX8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRX8"/>
    <dbReference type="HOGENOM" id="CLU_014722_7_0_1"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834537" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="38"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="443" mass="46676" checksum="651AE16E757E0EC3" modified="2014-03-19" version="1">MKYLLVVVALLLCVEVGAVTNPVMWILVHHSLKAAREDPIVSPGQLSSHAHSFVGANGVSATTTTASSLEEASTCTTAGLTADMSAYWAPSLYSYNADNDTFTPRTLDYVNTYYLGRGSAPLVAFPRGLQMLAGNATRRGAGPTQQADDAVSFVCLNYADGSSQSPTLPERSCPQGLRTQVIFPSCWNGQDLVSKSHSHVVYPLGDISQGSCPDSNPIRLPTLFYEFVWGVGSTNNAGNSSWVLSNGDAIGYSFHADFISAWDESILQQALDECRGALFNDLESCPPLAKTLDRKKSQACSAQSSEATSGNIESLPGCNVVWNGPHAGKGLAEGCDANKLMLKPASWPASSSTSAASSAASAAATSASAAQTQKPSQAVVAAASQSAKTSATPKVLPKPTSKSKPKPKPNPKPNPKPVKKPKNKKPSKKPLAKSQTRKPKNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRZ0</accession>
    <name>W3VRZ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRZ0"/>
    <dbReference type="HOGENOM" id="CLU_010743_3_0_1"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="318"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="5">
        <location>
            <begin position="476"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="624"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="75459" checksum="95C3230B60C0E6DD" modified="2014-03-19" version="1">MSGWQASHRHALTPRINLGADEDDGLDYSAAAHAGPSHSSLRHHTNDPRSTRSNHIYHDLDQPNRPPPRPFGPPPLLARPSQPRAVSKPARTPSPEPDEDVLAYIRAQKQQQASSTHTQHELRLAQQLKRDKFQHGASRLKSRVDREREADERKRRQAEHDAQLAYHEFVAAMGGDGDDDVRLQRSQAGSSRAPAKKAAAFVAAGGKAYVGSRTAPKTIPDASDPEANFVSSAFGNESDDGITPTSPAQASSARNDAPKRKRHAMDTFLSELQTEQAERESRLADLASATNTSISTLLAHETQTRPRGSRHTGDTPTTNICIVNLPPGVDERGVGEFFAEWGDVATVKIMWPRQDVRDPRALTAFVAFMTRDAAEHAFKQADGAMWGGVRVRLSWGKQVPLPKRPMYPQAVRRVNDDAEAPSKGAVPRLVINHRRDLPSKPVVDDFSDTGSADLYSTDSGEESETVSLRSTRSSALGSRAHRRLCSMLRSLTLRRERIARITAFAYDHATHYSAVVALLTQSLLQPRTPVPRKLARLYALSDVLHNSCMPVTNAWRYRAAIEARLPLVFAHLGLVARSFAGRMRREEFRAKVHAVLDVWDGWIVIPPHVLDRLRSVFDHPPAAAKATVDSNDAEKDEQQPGGKVVQEDVDGEALDDAAPQDQEDIDGEDLDGEDLDGEDLDGEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS57</accession>
    <name>W3VS57_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS57"/>
    <dbReference type="HOGENOM" id="CLU_027164_0_0_1"/>
    <dbReference type="OrthoDB" id="2524557at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="721" mass="77944" checksum="F3622348198DB139" modified="2014-03-19" version="1">MNPPPASFATNPVPALIARRTTVLAPPSLSTINHLDGATHPAGRNAGTSATRAAQERRVAGSQAPPRVSHTHHRSDLQQAVSQPTAAVPISTRENISTSKSWSSGLALKNANYPTATASSTHHEFVLHPTFRSDAEHRGDVLVRVEGVDFFVHKHILLFSSPFFASVLLGEWKESRLSTLLDDDELADAADAAGSADDSPAEVEANQTQESPVCNEDPQADGIVSASDTASPAVANLALQAQALEGNDAATVERVVVHPEPSTDKLALDAEAGDVQDPDHLVTDSRRRSLLRASYHTALWSQEDAATSSCSIVDSPLPAGSSAEDSGLTAQSADEGSADEGASVSGTDEDGDAVQRSEAADAERQERKQAAAESRRVRSKSKHLAARLTLRKLESASKLQTIPTRSTSKTGSSLVAVATQGARSSDASPLARLESLATPPLSRRASCEVGATPPPEAPAGQGFDESRVAAEERTEQRGGGGRGGRYRGVVAVVELEEEAAGTFHDFLFHIYPHLDLAVTWWNCGPLLRFADKFQVPYLRRSCVNFLRAALAGRPIEAMRLAELHGMDDLYKEASRHVLDNFAAWEVEELECLSKETLLKLERKRTWFLERLLKLGLANPARDYECHASCADPQTCARLLHDKWQSAYANAFRFSPPQPSVIFRHLRELDNASVLHMSACQSAARSWVQGLFDRMFSLGTLHTPRQFLAIKLEPPTKTPHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS97</accession>
    <name>W3VS97_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_01228</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Prevacuolar compartment membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000700_0_0_1"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000004">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000801">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000998">
        <property type="entry name" value="VPS10 homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833240" description="Vacuolar protein sorting/targeting protein 10" evidence="18">
        <location>
            <begin position="34"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1379"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="19">
        <location>
            <begin position="58"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="19">
        <location>
            <begin position="730"/>
            <end position="1375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS64375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1497" mass="166971" checksum="0219AF928301BF2E" modified="2014-03-19" version="1">MSPRRAGRARQLLVLLSASIACLLVLLPSFAAAAEPGVSVSRFAHLPSKISYFDDSTVALYHDATQGIVFRSEDEGKSWSPVSGSSRGKAAMLVPHPFDKKQAFILSRETTHWRSIDRGKTWQEFLTPEPPATRAGAPMEFHADEKHWDWIIFTGKKCSMWTPWGGRICHDEAYYTTNAFATNPAPLLEFVMHCNWAKTTPEMETSPDAMSRIFCIAWEDAKEERRAPASGATRLFQSDDFFKSRKMVELDMGRNAKHFAGLGPSKRFLVTALRDSQGSSSKAGTEMALFVTRDGVKWEKARFPHGSELRENAYTVVDSTSHSIMIDVVDSIYDNTGVLFTSDSTGTEFVESLRGTRRTPQGLVDFEHLVKIDGVGIANVQEDADTAVRSVITFDDGSSWQTLKPPTQDDKGKRIDCDPSDTKNCALHLWSVSGKTNVGKLYSSLAPGFVMGVGTIGRGLKDYDECDTFLSTDAGRTWKMVSRDAHKYEFGDQGSVLVMVDDEDVTDHVSYSTNFGKDWHKLNLGVKMRAKVLTTIPDSTSLKFLLVGSQTRSQAGTQDRNVAIFLDFAQMKKRKCGEGDMQKWYVQAAAEGSCLMGHKQWYKRRKPDADCFIQDKFHDPEGKEDPCPCTDADYECDFGFSRDTRGECVATGSEHIPAGACAKPEDTYLGSSGYRKVPGNTCDPNKGIHKDEKTQKSCTGKNAPEAGKVLHKSFTFPSLVVDKMYFPESSSVLVQLADGSVFHSLNDGYSWKQLVSDGPPAAEDDRFLTMALHAYDNTRGYLVTAGQRVYYTTNQGASWSWFTAPLPANGLGIAILDFHPDKSDWLIWTGSRDCTFSVGKECHAEAWYSINNGNAWDKLETYVRTCSWARDKKLKMDARTIFCESYLDKRGNQRDFSAANKLQLIRGDEFYRRKAAVFEAIVGFAVFEQYLVVAEYVSTTSTPTLRLQVSLNGHDFAEIHFPPGMELGTRAYTVLDSVTDAIFLHFTTHADAGSEWGTLLKSNSNGTFYAQSLDFVNRNDKGFVDFEKMLGLDGVALVNVVSNPDDASVSRQKDLVTRITHNDGGRWKPLVPPSRDVYGQPYECHQVGCDLHLHGFTERDDPRDTYSSPSAVGLMMGVGSVGRKLAPYRDSDTFLTRDGGFTWEEVHKDAHKWEFGDQGSIIVLVNDEQATDTVLYSLNEGLTWESYAFGEKMRISQILTVPEDTHRRFILLGTPSGSATKSVAIFLDFSALESRKCVLDVAKPESDDFELWSPSEERAEQCLFGRQTYYYRRKRRADCYVGEKIVQPHSVSRNCSCSEADFECEFNHYRDASGKCVLYPGVAPLATDEVGQCWAADSDGYWYDRTNVRKVPYSSCSGGQRPDRGTAHVCANNLAGHGFLWWATVILCPFGLAGLVGYWWAKKQSTVVGGRIRLPDGSNRLYAPDSELVQNLASVPRFVLGAASAALARLREVVSERVPFVRNRLSRRRGAYGGYRHLSTDEDAAILRDYEEDELDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSE7</accession>
    <name>W3VSE7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSE7"/>
    <dbReference type="HOGENOM" id="CLU_025093_0_0_1"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="10">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="370"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="492" mass="58099" checksum="D42E6705F2C50773" modified="2014-03-19" version="1">MRLSSRTNSTFLLDTHLYPAYLDRNGTSCAVHPQASAPNPYTMGGGDLNMKKSWHPLLAVNQERVWKREKEAIEERKKLEELRREREQEREMQQLQRLQEEAGGKKRVDRVDWMYATPATTGSKSAAEMEDYLLGKKRVDKLLQGDEAEKVSKSSQQGPISLQNANSARDLAAKVREDPMLAIKQQEQAAYEALLRDPARLRKLKAQAGIDVDAESKDERRRRKEEKRRRHEHESSSSSSRRRHRDNDDDDSHRRKESRHRDSHSESSRRRHHRHGDDAAVSRDRSPSRRGSERHSSRRHSPDRRREANRDRDSLRDDRRSFRHEERDRNGPAQSKRPRSRSRSRSRSRSPARERRAHDDRARHSQHVPRTTDDRRDLFSPRDRPDAMRPRNNEEDDARKEEVRLQRLREMEQNAKSMEQERSSYVRKINTEEAEQERREAELRQKLLDARTKGHGDGKGNFLLDQQRKTLGDSVDLSERMKRDRGRLQRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSG5</accession>
    <name>W3VSG5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSG5"/>
    <dbReference type="HOGENOM" id="CLU_894792_0_0_1"/>
    <dbReference type="OrthoDB" id="2553346at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="276" mass="28486" checksum="82B3EC6ADA62047D" modified="2014-03-19" version="1">MNLLGELASSSSALLFGPPAPVAKDPPPPPKRTPMTASRKAALLKPNLGLSEQTQQDTKDEAPLPVIPETETTAASVLVSTGASALSFLGSTVVSLTSAAASALVSPHPAAETDNATSAEPGDKEGGTMLGTLSSAVFSSAASVRDMVLGTADTAPTTYAANDSAPPRVKRASTLPVQLTATGEPFSDDPSVSAMQRIPDHPCGHVAHHKLTHCCSAPAIPTAACTCTCFTTKDPQCECDCHTTAANSRRDSGHFHRVEQLVKGTKRVVRDIKNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSG7</accession>
    <name>W3VSG7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-phytase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSG7"/>
    <dbReference type="HOGENOM" id="CLU_020880_2_2_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833245" description="3-phytase A" evidence="2">
        <location>
            <begin position="21"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="60539" checksum="ACBFD69CE42C5619" modified="2014-03-19" version="1">MQIAPTFLALQAVVATAVSAALVPRQAASNSSAPTSISPDNPFPTNVGYAGTVKTGAPPFLAVTDRIQGELKDSSIETRWKPIDAGDNDSYNIFQHLGNESPYFSSPLFADFQKENAVLPDTCTVKQVHILHRHGARYPTSYATEGAPYFGQVIANVSKLNHPDSNFSASGPLSFLNNWTYQLGAELLNPVGTQQLFDSGVKHYYRYGKLYNATDEKHKPVVRTTSQQRILDSARYWTLGFFGWDAPNKINLEVILEGGSGLGPADAFNNTLASYDTCNNSDTITVGDTYLRPTWDAIYLPNATQRLQQYVSGLELKDEMVYGMQSLCAYETVALGYSNFCGLFTKQEWDGFEYDLDLQFSGDYGIMSPNGKAQGIGWVNEFLDRLTNTTFNASTITTENSTLDSNPTYFPLDQSMYVDFSHDDIIVSVLTALNYTQVIGDFLDPTYADPERTFVLSHITPFAARLVFEVVECGDDQQQYVRTLLNEAVIPYSEAQGCPEGKALCPMADFVKFQQTHAYKDANFNKACFGQNGTDFVVTGPVRNGTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSH4</accession>
    <name>W3VSH4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSH4"/>
    <dbReference type="HOGENOM" id="CLU_335590_0_0_1"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="333"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="838" mass="92488" checksum="BA715528694771F0" modified="2014-03-19" version="1">MAASVDVLLLGSGWTGSFLIPLLSDQNLSYAYTSRSPPDEKMPNDPHRIQFELTDPVTKQSLRPLPSARTVVIIFPIKTLAQVDDLVREYEAIHGSTRWIQLGSTGIWGSGTHNSSSPFDTQNARAAAEQRLLDVTAKARHPRAAVLNLAGLYGGLRQPKNFASRVGATKDLLGLKGSVHFVHGLDVARAILLLHQSARSGWGRRWILSDTRVYDWWQLFSYLRPNIPDHPDDSPETAQRWVRELQHENHIRTLPRPIASEPDQKLPHYLERALDGHEFWHLFNESPQVDSVYHGGEHGLRLEGSPGRDEKHRMSQDDSGTHSVGSSTKSFVVRPFDPTIPEDKLRDLIERIEVDAKRPLPTKASFEGSYESLGLTHERFCKLRDAWIPFLRSEPTTNSDASESDDSTSISRRAGPDHDTWAAEQARLSSFSHYKVLIEDVDLHFIHERANPPASGTNIKVIPLLLLHGWPGSVHEFLDLIKPLAHPGNLTPVHFDVVVPSHPGYIFSSSAAGLARDPRTGHVVGMHSGPGGDLLVKDVARIMHNLMQRLGYRNYAVQAGDWGSGVLRSMALQFPNHVRAVHLNFCPSLAPSLVLPIVGRQGTPSWVLRLPQLISKQRYSQRALGLFAGWSQGARSSDLCGAGGLVGKAAEFLAESAWRGLALISLGSLPSPLSQEEREGLERGMEFAATGSAYAAMHGTRPSTLGLALSRSPLATLAWIGEKMYAWTDADPDPSTILANLTLYETTETIAGSFYSYRNRDAGGIAAIVSDPHNYIAQPTGYSSFPLEIIQVPESFVKASVNLRWFRKHLEGGHFAALEQPAALVEDITDCFAEIWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSI1</accession>
    <name>W3VSI1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSI1"/>
    <dbReference type="HOGENOM" id="CLU_115926_2_0_1"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12849" checksum="726B21EC18DD6703" modified="2014-03-19" version="1">MDFCFFIPVIFGCPTKIKQEGDGSARVCPRCNNAQVVQAKARTWFELCWIPLIPMKTKHIYYCNICQWQTQQDGGFQPQVAGGFGGHQGYPQQPQQYGYGPPQGGQYGYPPPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSI7</accession>
    <name>W3VSI7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TBP-associated factor 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02062</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSI7"/>
    <dbReference type="HOGENOM" id="CLU_055002_0_0_1"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000071">
        <property type="entry name" value="Transcription factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="327" mass="33892" checksum="E2005EF40B3F7ABC" modified="2014-03-19" version="1">MPPTPTRTVQRGSVRQRQGSSLHPQPGSGAAGMAGLDGMSAQHAKVGRGPNAADPAGVPFVHPALALSSGVLPSSSSTAGLPPAVAAQIRGRRPFNHRNLFARDLRNLMYAYGDSPDPDPDSVMLMEEMTVDFITDLCCRARPSPYSLGLGTSSISNSSSAFGATLENSTANDGSNAVANGGDAMPQTLPPRAPHRLRVKLEDFRHALRKDVEAKKLGRMEQLLYADKVVTEARRVGGVEEAAERAGALQTDNLPPAPPNGDASAQDANMQDLDDDDLDEKDAKTGKSGKAKSKANGPGKGGAKGKGKPKTAAASRAGSARSSVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT17</accession>
    <name>W3VT17_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003387_1_1_1"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="397"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1339" mass="148725" checksum="FE4209115A262C93" modified="2014-03-19" version="1">MTNAVQQQSPDQHHRFQYTDASPSKRTAVDQPKTRHHKSRKSSLSSLDAPTSPPRPTSSKHSTQPKTPSVVDIPSMSSSGSDTDSYKDMLILEDWDATPTSSQSTGNSPLSPRLATVPAECAPPVSPSEKDVPDAQRQAPLWALFREDFDESGAPDRIYLPLARSEQQIARAKAPDPPRSAVEPAKVAVEPSKGALIRSIPSAPGPSATFSSEEPSFAAKAEPKAVSHPRQHLGKPPLPPFNVVDGKMRIKIMQKQKDGRPGVPWGVQFFLASLASFGLLGFEELDITAGINTIRAETNLAAICALYHAANQRILWQSEKDEVPFLARQATKRELQLAQEQDREAEMLSVSRLDGVLGPPGEDMRTFGGRVIFHGRISCTNNPEGTKAGKKATHLNFKVQLLPPKLGGSCRFARRFGSENILRLTMDRSLAREARRFPLHPKTREKHQEISDFFGRTLQILGRRFRPFICKDDIIFYLCIGSPDSSSAQPEFDCVWDFVDHHAPFAANGSSQLGKFIQRIQLGLSTSVPASTIDTITYVSDLCGDPRPVTGEQVIMTDGAATMSLAVARDVAQRLSLTSVPSAIQARVAGAKGVWYLDPNAQSWLPGEEPKRWIHIRKSQNKIEYPRDEPRDLSQQVLDLLTASRTTSPSSLSKQIILVLHSNGVPTETFAALQQAELRAITDSISNWEGPDLLVSKALAKVVDDLCQVEKLRAKRSTEAAEHRAQGMGLSDSTQMDTVGDDRDFFFEKGRHIWNGMPLSRPERAHDMLKIGFHPRSCSYLAGFLVEIADTAMKKVTQRFAVSIARSAEAMVIPDPTGTLEEGEIQFRFSGDSICDPDSRLALHHVPEGDVLVTRHPCLLPTDIRKVRAVVRPELSRFQDVVVFSTKGHTPLASLLSGGDYDGDLIRVFWEPRLVDPFKNADIKFAECPFEMNKVFNRSEETVSEFVAQNNDKNKEERDRALVERLVAGAFDPQVRGLYGVMHLYAAWQFGIESEQAVDLAHKFCQCMDGSKTGLTIKAEVRIADSKKYFGKLPAWAYDAEDPGDRHDWFADEDCTPIGAVKNSQQLESVLCTLWVAGKEEAGRLKTRLHQMTEKLRGVEDMSLSGLWKQAKDLGQIRPEEEEAIRNHVKVMEESYVLTNSRTRREIENRNRGLQAKAVLKSRQERSAPLRRVRSEASSKMGSGAREKLLQGTAVDDLESSDMMDRLDETVEVPVVLDSASEVAMRFCQWPKAFAEQHIAKMDKAAVERLEMLRASYAYSVTYASKPRFAFEMAWRWMLNFKAEAAGSAGTRNHDASTYSPTPGRGCMQVPYSTLDVLCINKKTIARSIESARNGSFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTE7</accession>
    <name>W3VTE7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01317</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 13"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTE7"/>
    <dbReference type="HOGENOM" id="CLU_029848_3_2_1"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="25"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="312"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="344"/>
            <end position="346"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="426"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="438" mass="47936" checksum="865C11351D902C17" modified="2014-03-19" version="1">MAAMPKPSDSKTGGKATVLLGSQWGDEGKGKLADVLSGQMDVCARCAGGNNAGHTIVADVNGVKTKFDFHLLPSGLVNPRCAGFIGSGVVVHVPSFFAELDNIQKKGLNCDGRLFISDRAHLVFDFHQVVDGLKEVELGGSSIGTTKKGIGPAYSSKASRSGLRVHHLYDQELFASKFRKLVEGRFKRYGHFEYDTEGEIARYRAFAERLRPHIVDGVSFIHTALAQNRKVLVEGANALFLDIDFGTYPFVTSSSTSIGGVLTGLGIPPTAIGNVIGVMKAYTTRVGMGPFPTELHEEIGHHLQEVGAEYGTTTGRRRRCGWLDLIMMRYSCLINGYTSLNLTKLDVLDQLKELKVAVGYVVDGKELPSFPADLEVLAKVEVQYKTLPGWQQDISKAQTWEELPENCRAYVEFLEQFLGVKIEWIGVGPARESMIHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTH7</accession>
    <name>W3VTH7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTH7"/>
    <dbReference type="HOGENOM" id="CLU_2672114_0_0_1"/>
    <dbReference type="OrthoDB" id="10493636at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="75" mass="8460" checksum="087A384F519F301F" modified="2014-03-19" version="1">MSPTRARMADAAWLTAINMLGIVLTMAQLPLVALVSFSGRHPSRPNTLLKHATQLMWDAHDWLEHAELHPPSIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTS8</accession>
    <name>W3VTS8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTS8"/>
    <dbReference type="HOGENOM" id="CLU_756760_0_0_1"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000111">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="291"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="366" mass="40204" checksum="D57AA70B618989DA" modified="2014-03-19" version="1">MAGESLIQTNPTSSSRALPFANFGSASCTLGRSIVLALGRIVASPRASPTALDAHPLERNWIHPKYTVALAPPKKPDSASHAKTMNAKPDDTLTTSIRPNPSRCSSLLVSSRLVSAAPRRARSLSNRIQSRLCINIRWTFTSPSPSPTPPLLLSLLAPQTLAGAWLALHRSAPPRLASPQRFRSPLAPQNTYKVAPLALARPTPPLLFYNHHLKPNSTKMARTKQTARKSTGGKAPRKQLATKAARKSAPAAGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLLLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEAAEAYLVSLFEDTNLAAIHAKRVTIQPKDIALARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUC4</accession>
    <name>W3VUC4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_01265</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_5_0_1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="864"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="424"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="620"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="718"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="509"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="536"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS64412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1463" mass="159952" checksum="A2AE54866ABF1E15" modified="2014-03-19" version="1">MSEPDRSSAADRRGQPSAKSRQFEVAADEYQAPFQLPAKKLAAQPADNADAQQTAAEAFASSPYFDEQEAREAFEWAQAQREAGIDGDAGADAGTAASGGVEIGRRRRRDSQVGSYDEGGSIFDGPGAGAVPSSVSSMRHEMARPELGRRTSRSSRRRISMEGRSPRRTRKLSSASAQSDAVTTSSERSVSPDSVAGRRKPASQRSGSAYRFGRRKRLSVDADLSSSSQPKGMLGSILASIRGDRTDDDNEDARSRRSFSRPLLSRRRSSGSVVSSRGGRSDAGHDDDDEDDDDRDDRGWSDDDYGFDDEEEDDESFNTSDEDETPDRSGLLPSVFGTLSGAVDPVFGDTRFSTDHPPEDELDAELAGRDLETGDASGFGRSDADVRPSSRDQGRSVSAAEAKREISFLDKSSRSRQQVYLAEEDTTIRFTGYRTVVVNQIMYSVICFLTIGIAYLIGRWLPRFRLKYVCKETDFESAEFIMIENQWGDLHKERLTTIPFARPLATVFPHSSREPPATQAESQSAPTINLPPELVSKSNAPSKTASAKSSIVNGGTATPNLNGNGTSAQETGGLPMLSGVQTEQLMELTFFDYRYTRFALHPPTGRLRMVKDWRDPLWTSLGAINNGISHDAEKDRTTIFGQNVIEIQAKSTWQLLVDEVLHPFYMFQIVSIILWSFDNYYYYAFCIAVISLASIFTTLLETRQTVNRMREMSRFTCDVRVLREGSWQVLDSGALVPGDVYDVAESGLLLFPADSVLLSGDAIVNESMLTGESVPVSKVPLTTQSMVGLHAAGTEVTPDLAKHFLFSGTRIIRIRGSGATDKGDAGAKAMVVRTGFNTTKGALVRSMLFPKPMGFKFYRDSFRFIGFLAATAGVGFTFAAVNFVKIGIAWHTIVIRALDLVTVVVPPALPATMSIGISFAINRLRKLGIFCISPNRVIIGGKVNVFCFDKTGTLTADGLDVLGTRTIDLKAGRFSELHETVDEMPVGAGAKSDADARKMPLLYALATCHSLKVVDGEVIGDPLDVKMFEYTGWTLDEGKERAAKATTKSGTAKNGKSKLTERPPALVQTVVRPPGGQAFEVEDAIKSGRHAHFLELGVLRTFEFVSSLRRMSVIVKRLKSPSMEVFVKGAPEVMADICDKDTFPADYEDLLSYYTKHGYRVIACAGKSMAGMSWIKAQRMRREHAESGLRFLGLIIFENKLKEGTAPAIDVLRQANIITKMVTGDNPRTAISVARECGMVGPSAHVFMPTFVHGGERDARAVIDWSSVDDDRIKLDAYRLQPREVDPHVLDLEEFDFHDYQLALTGDVFRWMVDFAPVETLRRMLIKGTIFARMSPDEKHELIERLQALGYTVGMCGDGANDCGALKAADIGISLSEAEASVAAPFTSNRGDIGCVIDTIKEGRAALVTSFGCFSYICLTSLLQFCSVLLLYSFGGSLGDGQFLAVDFGVLTLSVFSARTGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUD5</accession>
    <name>W3VUD5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAC-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUD5"/>
    <dbReference type="HOGENOM" id="CLU_057806_2_0_1"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="6">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS65154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="191" mass="20635" checksum="BE5BBAB50C949272" modified="2014-03-19" version="1">MSATVEEIADSVQDLNVQEFDSDDAGADVHASDKVASRAERKSRKALQGIGLKKVGGITRVTMRRPRGHLYVIAQPEVYKSSHSDVYIVFGEAKAEDMSQLAQAQAAQQMAQAEAQERLLAESLQTSQAGGAAEAKAEEEEEDDDSPIDEEGVDAKDIDLVMQQVSCSRRKAVKALKESNGDLINAIMNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUF5</accession>
    <name>W3VUF5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUF5"/>
    <dbReference type="HOGENOM" id="CLU_029724_2_0_1"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="317" mass="35536" checksum="4A841F1A565C87A9" modified="2014-03-19" version="1">MAEPAEAAPHESRPEQPEVEATISTLLAQNRRTATAFTVTKHSNDAAKNWDKFYKNHADKFFKDRHWTSREFGTAVGSSSVKPEDDRDEEAQLVAADVARQGSAVLLEVGCGVGNMLYPLLEANAGLRVHCCDFSQRAVDMVRTHPRYDAARVNAFVFDLTSSQPSLASLLKKEPYDAWPAPATVSLIFVLSAIPPHLHLQVLKSLADLLADNPSGGHILFRDYAYGDLSQVRYHTKKDAAWAEPSLLSDEPGQNWYRRGDNTFNYFFQPHELDALAQQLGLQGEAQLLRRTAVNRKSEVNMQRRFVQAKWFVPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUJ3</accession>
    <name>W3VUJ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00949</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002662_0_0_1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833424" description="GATA-type domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="1525"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="622"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="739"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="855"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1185"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1264"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1397"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1576"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="855"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1185"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1397"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1449"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1490"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1601"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1618"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1660"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1671"/>
            <end position="1685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1758" mass="182592" checksum="3609A17B3ECF0001" modified="2014-03-19" version="1">MAPAALALLALVPAAPSSHCGEGTGFNCDPASHAAGRLCQPATEKLGLAESTSPTTAFATVDLASSLARVAPALWLAVIQRELSAAFKSKGRRDQEFGSLPTEALTASAWISQALPTARTHTAYRSRRRGHGLQADDGCTVAPPALDSDDKSHRSSHRQRIARHPAHLHPPQFASALPSTLARPCLFKHRIGSIRKPLRSGIAHASHHRQAHRTLRRVAARPSGHRSIPASSYSMAGRLHRSTSSCLVSTPFVPTSSSAKRLPHLSALASSSALILICTLAPLTLSIRTTAMRRFDPHLSSIVQRSSIVLPGTPPQSGTTTPLTDELLQDTSLITSTVHVDAADKLAPQSGSTASSLSTETDKPRSTAPHHHSILAHYQHRASLASLRTSRPLSYYDPGENKPPTPPWADALPPPSGPGSIDNLLDSSAAMSQGPSMPQMSLLSQAMQQHLTRQQMDAMASHDPNAASATHTPSGSALPSPALAGPGSPFSYGPMPAGADAASRPSFPHQGSFGAAAAQMPFGSYMSQSHSRRASGYATNPHSAAPSAGPSRSSSPSRAAHAPLDATSDLASHPARSFSGASQAGPEYGTSFGSQRTHTNGVPHVMPVHSNPAAMAGPGSWTGQQGLSYAPTPQNSFVPNQSAMLPPHHFQPASHQQASLYLHQPPSHPQHPQHLQQHPQHAQPLALSHQQAAQFSNYRGGPDALLSPEAVTSADFAGFFASAGGATAAAAAAGAAPLTAPSAAESRRSTQDSRSRQSTAAFPDELGVDALPGNLNMSRRGSAGAEDAADDEDLDPDEMSKKDPLATQVWKMYAKQRSQLPNGARMENLTWRMMAMTLRKKKEQEAAEAKLALEAQSNASRSHASSARHSPTLSSKSAGGSRRSSGSFPGDPAAFAGGFTAIQSDASDVPEQRSRAASGAGANAVKGKTRFAEVIQQEEEERGRRGRSPRTPESAATPAGAVDIVDWRMKSKSRSRSRSVSAMDVDWRGVSRSRSRAPMRLDTIDDEGNMDGAALFSRSAPNANAFDGFNFADLAQFDGTDAFGAFDSALDTDDFSDLLRPNGANASHMPGYGGASASGSARRTSSAARKVQMQNAFRSAANTDLFGAESDAWSAAEAESSRAAELRKASMDMASIGAANSFGAPFSTLDSIPGIGDFVSIAANQHPEYGFLPRLVRKTSFDHKVRERSMSRGPRRDQLAAEAANNRKRPFRDDLSPARPPMQIPITIDQRIAAGLSRNIASLGSRGAPTSSLSLSSVPSGSFDFAVPQPGSHPHQQLPLGANTALGHPTNRSHETATDFDSLLETLASQAGTPTTNLMTGASASPQTALGSGSGASPITLPNGAAAAGQQNPADLEAIMNMFYNSDAGLGGPQPSFTHINPNQVFGGPIDNMASSLGNLTASGDEASSNWTYSPSSGAPSNAATPPGLQHHGQYHRSPLSGSAKRELALAPESSASAASRSNASPSMQAIQKAAAMSEASRGKKVGSGPMPGGPGEAARGGPGAGPGPSVNLKDLPSASSMATADPPTVCSNCHTTKTPLWRRDPEGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRASGAQRADARGRGSSGGGSGNANIAPAGGANGTAKNGTGSGNAGSGQGSGRSRTNTNVSVAGIRTGNVPIAPAPTPPVSSPGSTGLGSSAKVEKRQRNKLSKRDGSSPSDSARPPFAAAEFFAWGPLRRHSSLRIPTARDPPTPRCPTKDTLQAKCIGASTPATVRQQDAMPNEVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUL3</accession>
    <name>W3VUL3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUL3"/>
    <dbReference type="HOGENOM" id="CLU_006320_4_4_1"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="703" mass="78526" checksum="2751E55014495422" modified="2014-03-19" version="1">MADSGKDAKFFQRSKVDELRTELNADKKDKGWVRKKTVLKKIIANATMGNDMSALFPDVVQCINIQVLEIKKMVYLYLINYARSKPDQVPNAIPGFLSDCNDRNPLIRALAIRTMSYIHVPTVLAALIDPLRHSLKDADPYVRKTAAICVAKLYMHDKRLIEKHSFIGMLRDLLADANPTVVANAVAALVEISERSDNIQLKLNLTIASKLVAALAECSEWGQTYILEALMFFVPADFADAEILAERIAVRLQHANSAVVLTATKVILYLMNYIASAEFKESLCRKLSPPLVTLLSSGPEVQYVALRNILLVIQRRPLVLQNEVKVFFCKYNDPIYVKMAKLEIIYRLANERNVEQVLAELREYASEVDVDFARKAVRSIGRLAIKIESSADRCIHALLALIQTKVNYVVQEAIVVIKDIFRKYPNRYESVISTLCENLDNLDESEAKAAMIWIIGQYADRIENSDELLEDFLYTFLEEPVEVQLALLTATVKLFLKRPSAGGELVPKVLKWATEEVENPDLRDRGFMYWRLLSTDPEAARQVVLGGKPPISTETDRMDRQLLDQLLLHGASLASIFHRQPQTFIRNAKARYVPDSPALDESARRYASAHLYSKPVARAPVLNTTAPSQAAAANAKTLAAPDSKRLIEEDEEAETEAEADGPLNGALGADEDADPYAMLPDDLGASSTYQADRPMPNPSSLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUM9</accession>
    <name>W3VUM9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUM9"/>
    <dbReference type="HOGENOM" id="CLU_072332_2_0_1"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="217" mass="23571" checksum="2D53C48D79E4F778" modified="2014-03-19" version="1">MASARITFDDFQSACCTYLAQRDALSTPQQHQLSWASYAPGWTWQDALLPGPAFSGTAGLHRSYAIIAHHNTTAEEKHALEDEMCASTQVADDTDDATYTPTTTRRVIQLEQSIHWSPVWSVPVLYFHATLNDRPISLDDLQGVGIVHDAGTLAAHLGEALQPVSVGDHPRSGLPSFYLHPCNTSSALSSLLAQDEEAQYVASFVALCASAVHMRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUU7</accession>
    <name>W3VUU7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUU7"/>
    <dbReference type="HOGENOM" id="CLU_012022_1_0_1"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="405"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="718"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="271"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS65309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="754" mass="84923" checksum="7F5B3A420B751595" modified="2014-03-19" version="1">MPDRWQRRRNDEPAPRGADADRRQSDFPNKARRLDDSSSRRGGDRDAHRQPAAPSITIRGVAAKQASPPAAASHRADDDRPSRARSPDLLERLARRTDDAPAKRPAGESGRPQAEARRGGAKLAPRGQYDDTGRRMDAPTSSHRGDAHTSPRRRDADARRHRDRSPSPAAQRQRRRDDDERHDRRREARGSHSTRHRSPSPGHASTSASRWDRDRYDTYERHRSPQSPPDRYASQSRRTAPAPRGVEAESSRRRRTPSPARSDTSGRSRRREREPEPLRKPARDRPARWKLDGREEERATERRDAGRERRRSPEPRRPRTPPRIGREDEAERGQVLSRKSAPSRAAEQEQNGARREAEAELRSVRGSGWQTVRPGSRNGKSSRDDDRSAPTVAAEAVRAEAGEAYESIQQVGEGTYGQVFKARSERTGAVVALKKIRMDSEKDGFPVTAMREIKLLQALRHENVVRLHEMMVTRGSVYMVFEYMEHDLNGILAHPQVHFTPAHLKSLATQLLSGLAYLHRKAVLHRDLKGSNILLNNQGRLKLADFGLARMYAKRRQGDYTNRVVTLWYRPPELLFGATQYGCEVDMWGAGCIFLELFVKKPVFQGESELGQIHSITDVLGPVTVEAWREVDKLAWYEMVKPAARDGETEARDHVKAAFGKHMPDAALEVARGLLTYDPQQRWSAPQALQAAYFSEEPHAELPAGLLSALEGEWHEYESRRAKKKASAQPPPEAVAGPERTGASTSAQGSRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUW5</accession>
    <name>W3VUW5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUW5"/>
    <dbReference type="HOGENOM" id="CLU_1030567_0_0_1"/>
    <dbReference type="OrthoDB" id="10516335at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="242" mass="26090" checksum="B5149290BDE4A2EE" modified="2014-03-19" version="1">MATAFVATEDKTEVLTVVMQAQLLLGYVVWVSEAEFGRALEMCANAAPPPPTNAFVITAHDWKAFIGRQIEGDVARRSILPQGSEASVDDRESNEGVDAESDFDPGADFESDSGSDDSDDSDNGSDDDDDDDGDTQPDGEEVYGFDGVDLDDLDGIKQVQPGTVETCQIAELNLRKCGKSLIADDRIQHERAAANTEWRALAANDRLSGINAVIYYTGTLISNSNGPDIESQHALARRKTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVB4</accession>
    <name>W3VVB4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVB4"/>
    <dbReference type="HOGENOM" id="CLU_059054_3_0_1"/>
    <dbReference type="OrthoDB" id="3197626at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="410" mass="44707" checksum="1A6D4802CDB9ACC8" modified="2014-03-19" version="1">MTDWKSPVVMGHAFYAATALMWLCVGLFIYDTLRFLRFDVSIIMGRRPRRWPQLPYLFSRVGLWTYLLTNIYFVVAGTEFNCNGVLQAVEMQMGWIAVSSSMLLAFRAVCVYSGRARTVVSLLLTVLTLGMLATWMVGVKDTKAAWVVGGGNPWQEGSCAFTYMSKQYSIKYIVTIVFDMVVMLLTVAGVVRMNGGSRIGAVLVNQGIQYFVLTALINALVTGLTLADLNPVMSLIGAIPSATISVMCSTRLYVKLAEEAAPKPEGVHSSQLSSSLSGSGAEKIARFFKRSSQIPSQLQPSMAMRSTSSSNNGTAVAGLTSLSYIARNESQSRDDKSFAISSHDDLEAQTTRAQPGTVVNIVEERTIVREPMPDHLAGVLYGRTSDTADEGVADHPYSTVKGHFPRLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVM5</accession>
    <name>W3VVM5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVM5"/>
    <dbReference type="HOGENOM" id="CLU_067861_2_1_1"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="202" mass="22296" checksum="3B608FBBA7CEF1A4" modified="2014-03-19" version="1">MADTEATKPTVDATEQAASGAAAEEAENDPHFEPVIKLENQVEVKTHEEDESVTFKMRAKLFRFDKEAKEWKERGTGDVRLLEHKQTHKVRLVMRRDKTLKVCANHYVTSDMKLSPNVGSDRSWVYNVAADVADGEPTAETLAIRFANSDNANAFKDAFEAAQKSNAASKSDAPPTAAEDDKKDAAPEAAKDDDKADDKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW47</accession>
    <name>W3VW47_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW47"/>
    <dbReference type="HOGENOM" id="CLU_009210_1_0_1"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="746"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="94302" checksum="550BB308B505C90C" modified="2014-03-19" version="1">MPPKSLVTALRDRYLNTIRSVQPPARWKVLVVDSFTKELLNSVLKMYDILQENVAQVDNIELSRAPQSSLEACYLLTPTSHNVDRIIRDLAPDAGRQPTYAAGHIFFVDSLSDALVHKLTSSPAEPKLRQLIELYTNFWPTESQAFSLKSPQSFLNLFQPLGGLYGPDPMEAMRTIDEELQFSTQAILNVCVTLNEFPLIRYYNPSHPPLGPLQPPKDAIKSQTAAANMYQGSARMARLRGTNNDAGLAGAGSDGPVAGEHFTRKLAMRVQAAIDQYVRDNQPKIESSRPRSVLFITDRSMDTVAPFLHEFSYQAMCNDLLAIEDGTRYNYTFYTAEGEREQKDAVLSDDDNVWTGIRHLHIAEAIDKLTKDFKQHAGEQGAFADPNSSLNDMRDMLASLPHMQEMKEKLSLHLTMAQDCMNRFEKSRLPQQAMVEQNCATRLTPEGQKPRTLVEEMVPLLDDRSVTNTDKVRIIALYIMYCDGVPDEDRKRLFQHARLGRYEMDAVDNLVHLGAQVVRDATASGWDAWFKKGKRKQQPGENEFELSRYQPLVKLMVEDHFAGKLEQATFPYVRDAPPEASTGLSLPVQTSALARVGLGGGSATTASAASARTQPSSLRSAKPTWHQKGRGGSNVGVERSENRQRVLVFVAGGMTYSEMRSAYQMSERLGKDCYIGSSHTFTPQSFVEVLKQFGKAGSREAAQQRPHHAHHEHRHHQQEQQLPPGARGLSKPLNDRSAIRTESLKHGAYPAHAGTNGGQSGYGSPPVDQSTYDRRFQSHAPAPPHHPQQHQQQQQQQQGPKSSLPPHVAADAGSGARSTSPAPSQASDLSQRSKDKKRLKNPFSFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWB5</accession>
    <name>W3VWB5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWB5"/>
    <dbReference type="HOGENOM" id="CLU_004965_3_0_1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="673"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="748"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS65071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="90251" checksum="ECCF03983AA71E02" modified="2014-03-19" version="1">MDPIDIKPAAAGSDTSSEKLKNESSDKDGVEVSNVAYVLKGDRADADYAGETPEPEEGHVVSSAKDIVTQVLSLDDNPSLNPWTFRMWFLGLGLAIFGSVLQEIFYFKPQTIFVSLVFLTVIAYAIGEAMAAVIPKSGFIGRWFNPHPFNLKEHAAITLMASAGTQSALATEALAAQQLFYGGYPSKAAGIFLVLSSQLIGYTMAGLLRSVLVYPVKLLWPQNLPLTSLLETFHGSKAPDSKTIVKKRMKVFWIVAGLIFVWEVFPEYIFPVLEGVSIFCLARQNDLVFTNLFGGASGNEGLGFLSLCLDWQYIASLGSPLWLPLETMVNSVVGYLGCIILFMGLYYGNIFRAQDFPFLSQELFDTTSNGTNAFIYNQTSIMTPEFIIDQKALDAQGLPWITATYLGYLITTNLGLTATFTHMLLWNFDDLKAGWEWASPSSIKKMLSDPNWYKFWYKRTVEEEAAWAEEKLNDDRCDPHYKVMMRNGYKEAPMWWWGALLVISWAIGLVCLYVMKSTLPWWGFILSSLFTMVFLLFFGAQYGITGFGFNIQPICQMLAGYLFPGRPLANLYFTCYTYNACSMGQVLARDLKLGQYVKLAPVCTFTVQVVGCLVGALMNYIMMLSIVDNQAEVLKSVQGTNIWSGQNIQQFNTLAIAWSIAKDMFSIGAKYEWVTIAYLVGFLVPLPMYFGNKIWPHRAWSYFNFSIISWYLGWLFVGINASIMSYFLIGFGAQYWLRKYRPVWFTKYNYIVSAALDGGTQTLVFILTFAVFGGSGKARPFPTWAGNPDTSVHNLDYCAVSPIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWJ9</accession>
    <name>W3VWJ9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWJ9"/>
    <dbReference type="HOGENOM" id="CLU_078858_0_0_1"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="233" mass="24444" checksum="0E71EB5CCEB8433C" modified="2014-03-19" version="1">MWSSLTASFSKLGLRNAAVAGPSVASAVRSLHMTSAARPSLHTTPASPTSQLGGARHKSNLAPRRTKYRKAHKITIPFNTGGSTKGTTVQEGVYGIRLLAPARLSAKQLVAAETALKRKLKVVKGAQVFLRVFPDIPVCIKGNETRMGKGKGSFEYWACRANMGKVIFEIGGPVEIRPEVAKEALRLASAKLPVPTEFVTTASAPRLGNKVLQPAAASSATGGPDSTPASTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VCU6</accession>
    <name>W3VCU6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VCU6"/>
    <dbReference type="HOGENOM" id="CLU_000604_45_3_1"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117:SF4">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="101"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="359"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="618" mass="67486" checksum="216AC56E9264854B" modified="2014-03-19" version="1">MRCVSRPWRAAIRFELLPTSSVARQHYACSSRGMAQVRQASTRPPLLDLRAAKLGSSSAPLDWTIRDAGADECWAIIAPASEQGGAVRRELIDILSGRQRPRTSGTQHTPPHPFLDHGRSAVRAIKHVSFATQMGSASSGEFTNYSARYGAIRDQDRVTLYERLMDLLDCPVGLVAAQKLVPDPLEQTEQVGRFKYASAAQREAALQKAQRADGVIRQMAPLLLIGDELLDRPVIALSNGQTRRARILSSLITGAELVVLEEPFSGIDTTTRMRLGELFAQLHAQRRPRFVLVLRQQDAVPDLVTHVLRVDEEGAIVSVGHRHTAGAAPSGKSQGGVGLIEANAAAGVGRGDTSAPPVVSLNGVSIVYGEKTVLDSVDLQLYPGTRLVLAGDNGSGKTTLLALLLGDHPRSFSFDADSLSLFSHARDHASNARTLLNRRIGHLSPELFNAFPRRPAAAGGLSVGEVIASGFENVFARRCYTDEQKQRVWDLLGHFGDLIKTRSPQASSEVRAVSGMGFSELSHGSQAVVLFLRAVVGHPQLLVLDEPFQGMDQRQVERTRQFLDHPHLFPLGPAHEQHSDLQQRRNMAIVVVSHYESEWPTSFGSLLRLRDGQVVQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD67</accession>
    <name>W3VD67_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD67"/>
    <dbReference type="HOGENOM" id="CLU_1587214_0_0_1"/>
    <dbReference type="OrthoDB" id="10274858at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833064" evidence="1">
        <location>
            <begin position="25"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="171" mass="19803" checksum="32EB6E5E6CD94245" modified="2014-03-19" version="1">MVAIAQRLMKFFLLLTVLVGICAAAGNRIPNPTMNDMDWGMVDRATMDQAQRFRDIGATWNRRELPPNQRVPNFVNRAMSLVQERARFVGSYVKPNRNPDLMGDKITYFYTLVHPNERLGREMGLGRNMGDILFKHSSLTNTYKIVRVSAIEHNPQVNWMFEPLEQLLRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD72</accession>
    <name>W3VD72_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD72"/>
    <dbReference type="HOGENOM" id="CLU_665847_0_0_1"/>
    <dbReference type="OrthoDB" id="2556674at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832860" evidence="1">
        <location>
            <begin position="26"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="413" mass="45581" checksum="E24DE51C91DC670A" modified="2014-03-19" version="1">MFAGHWTRPVAVGCCLVAIVGFASTQPVGNDYERIAGKGALASDEGASSSRVGMPVDLDLHLYNPNSFQQHPPARTYSFSPFHPGSAPMLGAQPGVGAGESAVWTPSHQVPQHVGQEPQGSGVHPGPSLPVLSPPTEAADAAAVGQPWWEDALPKYATHSQVYERWTQALRTILGNPYLQFTSVGDEEGSRSRVVVARDRLLRADRLVPPAAGERMLWGSLKAEKSDKKAGLKHFLYRLHNAQAVKMGEMTSRATTGRTYVYLDSRFNMDWYNHMYFGNRLRFIPIRAEGMSWRTMNNLFMRRRFVLALPSLSPNGLPLLVGRHTFQNGMHEVQDFFPDGLEDPRQIVSLWSPALHGMDRTTMVLYGIGQLDMRDDPQGGGTVKRLEAIAQTAQGTNLKTNYDILTELPHILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDH5</accession>
    <name>W3VDH5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tim-barrel enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDH5"/>
    <dbReference type="HOGENOM" id="CLU_058589_0_0_1"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIM-barrel" evidence="1">
        <location>
            <begin position="14"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="283" mass="30036" checksum="3D3671A2BF902F11" modified="2014-03-19" version="1">MTYASQPKDGREAAQRLRDTLKSGKPIIGSGAGIGLTAKFVEKGGADLIILYNSGRYRMAGRGSLAGLMPYGDANAIVVEMAAEVLPVIEHTPVLAGVCASDPFRSIPKFLRQLKEIGFVGVQNFPTVGLIDGNFRQNLEETGMGYDKEVELMREAKQLGLLTTPYVFNAHEAEQMASVGVDVCVAHMGLTTSGSIGAKTAMTLDDAVKLTAEITAKVHSISPDTMVLVHGGPVASAQDAQYVLDRVPGLAGFYGASSMERLPVETALEESMQGFKNLKVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDP5</accession>
    <name>W3VDP5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDP5"/>
    <dbReference type="HOGENOM" id="CLU_322133_0_0_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="899" mass="98046" checksum="A64D7AC1CACAFCBE" modified="2014-03-19" version="1">MPDQDVRGDGAEGVPATAGYGPPRREEHMEPSNHSADDGLVVASSSAPSDARDAARDEHSDTTSTHPRSNRMRPSDTLRRSQACLACRKRKLRCDARKPTCTRCEKAWLAYYDTNRVNDPSQLIPPPCEYDTSLLAKIFQGNTPADGAQGASSSSSHSRARDSTYPEQSENSAQLQQENEQLRSQITRLERRLTQVEATPDTDATRSEGRYASSAGNAAARVSVQELTSRGKSAEPTHKRARYPDDTFPSGGRLVSSRSVLPPIHSSRLGDNVLLRERQNAPSYGEALPSRNIETRPHRASSTSSSASRPALGWQAPPHYLDNIPASSPTQASAAQPMVPPLPDRQSLHRLIEMCEREAWLFGAINTFALSDVMILLETAPANDTDTHTATAVMLALVATALPLLAPACPAGIRSSTIFTSIDARLRKSGKLDGVSMNDTMEWISTVCKFYADAARYLLSQVQGNSESQTLIASLVVRVLLVECSLGHSAMRTAQADLAQAASEARLLHLHNAASTDLPRLGEAPSRPSHLGRALRGLATGSEQGFAFWSLFLQDCFQNRLATLPVMLERQEIQTSFPGRTESHSPVSPPKRSEDVEAYMQRRRGLPAFHVLDTSMTLLVKLGLVLDQCCEYSNVARQSLQAQGGNMAGSEVLDQRFGAAHEAIRNSRLMLSQYDERMSRRTHAYDHSNPTDGKKDAMVASVMLRDPLRFAAEVTHHLAVLRAFEGAINLAAPPPPTGQARDMIRNAAIWLSRLADMALEQAPVLFGMPAFCSTAFFIGARWLLFLQSSQPNEFHQDIAAIVLALRERAASFKSDLVLARAIVALKKERDVYGRVCVSPFAWPVEAVSEFISIDSQSQPRARPQQVLPARKASYVSIASLAAAVEDAAVIQLTTGTNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEJ3</accession>
    <name>W3VEJ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEJ3"/>
    <dbReference type="HOGENOM" id="CLU_143683_2_0_1"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12196" checksum="BDE5A81C8C48E802" modified="2014-03-19" version="1">MFGFGNHEEAADFVYNQDPQEHQSKFSHEAVGFGAGFVAMREYEKRQESKGEHPKHEFAKEMLAGIAGAEVDKLFETKGLDFLDREEAKRHARKQAEQLYDQQYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF55</accession>
    <name>W3VF55_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF55"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30581" checksum="D6055F5F6C5FF913" modified="2014-03-19" version="1">MPGLRLPHRVAVITGGGSGIGRECAVLFASEGASVVLADINIDACQNTADIVNERFKDANPPVKAIAMKCDVSKEDEVAAIVKRAVDEFGRLDVMFNNAGIMHPADDNALNTEEKIWDLTQAINVKGVWYGCKHAIIAMRNNPTDESKDLHVGGSIINTASFVAVMGAATPQIAYTASKGAVLAMTRELAMVHAREGIRVNSLCPGPLQTPLLMDFLNTPEKLNRRLTHLPLGRFGEAVEQAKAVLFLATDESSYVLGHDLLVDGGLSSAYVTAEGQPVLPAPKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF66</accession>
    <name>W3VF66_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05715</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_259371_0_0_1"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902903">
        <property type="term" value="P:regulation of supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="12">
        <location>
            <begin position="47"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="12">
        <location>
            <begin position="365"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="747"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="910"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1080"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="638"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="771"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="928"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="971"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1327" mass="140863" checksum="AE688B8F1362DA5E" modified="2014-03-19" version="1">MPEQQRAPSTGPPFFSTSIAQPFQPRHLDITVRNTTAITHNAATPRTMVDADAIYELAQRIESSIEVDKRVAALHSLQSQLESAGYVVEADAVTSAVKVALKHANQALSTAALAFIPTYASMIYSGDGTESHSVLNHNVRMLVNSVGPLVIDKLGDQKERIREAARTALIELANAAYAISSGHITTSGKGKETETPLGIFERSLREAGLAAKFARVREQSVLLLPILRQNCEKYPVRPLVPITVELLSDADATVREGARSTLIALFSNAAPAAKADLKKELEKRAVRKQTADAILREVLAAPSSVTPSVLSPEPAPARSHATSYTDADAPARQLKTTAPSTHAAPPPSTASAAATATADDIRPVYIASRSDLERTVASMLPFFEGKESEHNWLNREQSMIKIRGLVVSGAHRQFGESFFVSQLKVVQEGVLKCVASLRTTLSMHAIHLVQELAIELGDDLAPCVEPFLTSLTAMAGFTKKLIANATQEAAAAIMVNVSFRPLYIQLIWHGVQDKNVATRTAAAEHLATVLSHHAAHRKHAVESHGGLDLLDKCFRKGVGDSNPAARTKSREAFWIFHRYWPDQATTILQSLDPSTKKQVAAMAPSDVEAEIVQEQKPKSAPGPVRARPGGASMALIQAKKAAALKAAQERERQKAEEAAAAHEARVAAARAALAEQQQQDEPQYEAYVDEAATPVAPQRKATGFMPTRHRSQQAGQGTELKPTKDLSVLLSPTAHQRIQTAIAVPLPTSPTPVVAANGSAPNRYNGHASLSFETPSQPRSPGLSPTVSRTRAISSSSFSSQGSGSASGSSARHHASTSTPRATHTVRLPTSDALDSDLADLSVADVGEGDETIDATQHARASDLDAGGEDETLQLAAPEDASMDLMGMNFASPFKVGADRAAKTRSVLFGRGAGDGGDSFEQTPQAVRTRTQPTKTPTRTVSSGSSNSTGSGTPASAVRRSGLPRPVSMIHSPTSGLQAMPRSTSQSGLATPSRAPTSGGVAAGTVLENRAQRLEAGVASPAKARPEVWTWIETLKAGTADLRTFRRLAKLSADFKVAARSAGDIHGGADEGDETVLTAGPIANASNRVAPSDEDGRSSGKAASGDALTSDTAAWEEGGLFVALLEGVQRYVPTRASETRSNADVEVSALAVLNRLVEHQYPVLCSTATERSLLDTLLGALDTLCGASVSHSSAVVAHKTILAAWESVLSTWAGRCDAVLGFDLLLPHALDAAIVPVLRSGYTPLLLRLPAQLVLEDFLPRLRGVIVQALRGDKAEQRLAATTMLKRLNDAARPHVADSHTRIFSALQLGDSDRALLDVLMYYFSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFB0</accession>
    <name>W3VFB0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein REV1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Reversionless protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_06431</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003901_0_3_1"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="156"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="486"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="253"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="342"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="939"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1036"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1103"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1210"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="974"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1052"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1210"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1235"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS59512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1395" mass="153592" checksum="D8095C609AFAEE58" modified="2014-03-19" version="1">MHKPSIRQHSDADSDPGPSRKRKVQWADEDDRDDARPLVLEDTAQFHFTETRVDENGMPIIASTTEGEDAEVQAEPASRDAADSKAHNLELRSEIYNPIEYGDFRSYMKHKRAKLKVQEAALLQEEEALLRVQADASDSTAKQTSLAAEIEAEGGQRSDALKGCCIYINGQTHPPYSELRRLLVLHGGDLMAYLDQKSPVTHIVASNLTPKKRIEFKDYKVVLPGWILESIELGRKADWRKWRCDAITGSNSHTSHSMVARTTQQQQGASTGVSDWRNLDRTAKLPKPLPRIGDEDQGTPWGKPTNQTTLLDRFTRTDNQPSIAPSIQKQSDVVADVNPADASTASNGKGVRFGENHLIEPVPPLPEEKSQPPVPEPVTPTKPKDMIPASVGTDPASKKAALAVTKSHYASRPSNTHAARLLASPSWRERNTATSEGFLAGYFAKSRLHHLSTWKTSLQDMVSSALREAGRPLASADLPKGVQRVIMHIDFDSFFVAVGLRKRADLHDKPVVVCHGTGVGVGMPAQKPGDENRPADNQSSSTSEIASCSYKAREFGIRNGMSLGQAKRLCPHVETIPYDFEAYNNISLSFYAFLLEHSDALQAVSVDEALVDVSLLLQSMRDGDAAPGSLYDRYRDHLGSQGDAWSAEKQLAEAFRDEIRDRCGCEASIGIGSNILLARLATRRAKPGGSFHLTDDSKQPFLDELDVDDLHGIGWSLRERLREMFETINVGQILAKTTERKLTAEFGPKKGKMIWDKMHGIDADRLEGNKLRQSVGSHVNYGIRFLTEQEAETFVTGMCQEVAQRTRAVKLRGRQVSVQVMVRAKDAPVEAPKFLGHGVCDTHHRSVQVSGPGGVAIDDEERIRAAAWPLIRDLRADPKELRGIAISLNKLEAAEGNALSPAKLKGGQAVLNFHNASSSSKAAPKQSAVSRETVLHLHKTSKLNEDDDTDGTAHEQIDEPGLELPESLEKGPTAGTSRRPTAASAAQGSVERTPAALPLSTQLMLPSRSQIDPDVFEALPTPYRRQIQAKFGEDTISEPGSQTRARVLPRSTPTTPQKAKAAPSAAMAEALKLPSASQIDPAVLAELPASVRKEIERQVGLVPDDSAGTSSVESTPTRRKNATTATLTRFLKQDPKHALFRSASESPTKKRVVNRLLHTAGQYAPKDQRAVDREEVLAMVPSKIATETLQGLGIDAEVFRALPMELQRETFRHHSEQRKSEQARFKAGKTSTFEELTHAEQRRRDTLRAAHSDPTAPPAFLVARPRWRIPRAEARILDSEPQSAVEVPSIRGLTRYEDVEQLIRQWLRAFAVTGPRRGDVDRIATYLAQTLRVAAQTRVEEAHKTDAILRLINEAISQEEDKGKLVARDAWRDAVQRIRSAVQAQAHSSFHGAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFD5</accession>
    <name>W3VFD5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gcn5-like n-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFD5"/>
    <dbReference type="HOGENOM" id="CLU_070645_0_0_1"/>
    <dbReference type="OrthoDB" id="2545846at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="286" mass="30566" checksum="255161F84531B3CB" modified="2014-03-19" version="1">MSAEGSSLYGGGGGGLSVPTSDAASPCNVGAYGSATSPSTASLSPSSGTVSVGKGTCRSSPGSVANLLALTELRKAAWARIYTSGISTGDAAISTTRIPSWKQFDALMIRRHRHIAVDPRDNRTLGWIACFHPYPQHACLYDDADAPSHPTVDGREGRVAEIQIMIAEAERRRGVGAFLVKALLALLGADTRYSTVQASFFPENKACFKLLERCGFEMAATRRNVAKMLDGPRAGDWRDLVTMELKLPPLPTLPTPAAHPNRTLSPTFELDSTIDPTAIQKRPRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFN6</accession>
    <name>W3VFN6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_05303</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFN6"/>
    <dbReference type="HOGENOM" id="CLU_021710_0_0_1"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="12">
        <location>
            <begin position="46"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="13">
        <location>
            <begin position="251"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="455" mass="51590" checksum="87328ECD92396B81" modified="2014-03-19" version="1">MAPLGHTASVPKVPGRKVEDPQQLAFLRQHVRDLCEVPHMRFPGAQPVSFEKASIDLLQSEDYWVCEKSDGQRVLILIVTPASTGRQEVFLIDRKNDYYKVDGIVFPHHMPHDPEAARLGGMRNHTLMDGELVIDCDDRGNQKLVLLLFDLIVLDRELLANRPLSKRYGRLKSYIYPPYVDYLKRNPAMAARRPFDVQVKKMDLAYGIQKVLFETVPNLLHGNDGLIFTCLNSGYVMGTDPKILKWKPPYENTIDFKLVLRFPPDLERDPRGNLPNLSTMPFFELHQYLGDSASDDYEFFDELWVEPEEWRQMAASGEQFDDRVVECVWSVDPHPATEPYISQGLSLPPRWRMMRIRDDKHHGNHRSIVEKILKSIRDGVDADELVSAAPAIRAAWKSPEREKLRQSAGQAPAPPALPPAGKFNPNIPFGGMAYQGVKGKAPPFTSGGPPGLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGD9</accession>
    <name>W3VGD9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_06177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGD9"/>
    <dbReference type="HOGENOM" id="CLU_072861_0_0_1"/>
    <dbReference type="OrthoDB" id="2552827at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS59862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29865" checksum="01AFD6A8D63A07B1" modified="2014-03-19" version="1">MMRGTLRALVTLSRTTRNTAIRRYTAASTSTHPRDSRLDLTTTVLLDALPAVSQYGFSKHAYIHAAGAQTDLDRRSRTVDTLFPGPDSTFEAALFQTWNSVSNHAAIRATTPQDIIAILRANGTLDGESQRPVRINAQLSEEEQRKALAKVAELMLDRLRLSWNARPHLQQGLAAVSTASPETSTWHSVFPHKTVLPDLPTPRPLLEMASGFVGEALAHPAAQQRTGWIDSDGVDWYAVRTRLTLAYLAATLHAAAPSITHFTHTAAFGAVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGG6</accession>
    <name>W3VGG6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_06216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGG6"/>
    <dbReference type="HOGENOM" id="CLU_2387098_0_0_1"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS59892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="94" mass="10422" checksum="8C22BB50E24C74EC" modified="2014-03-19" version="1">MFVVARISDPGLSAAQRLAYAQRYTALRISGLERSPHAFSSTLATEARLSDHEKLARLQEPGKTIFVCINSETDEWVGQVTLIGPQTRAEYDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGI0</accession>
    <name>W3VGI0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGI0"/>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="347" mass="37567" checksum="1F86330673776EEE" modified="2014-03-19" version="1">MSLVDQPATYQAFRRSADGKAIQRTTEAMPRALGSKELLIKVNAVSLNYRDVAMLLGTYPVPCLDNGIPCSDASGTVVATGSQVKTFKVGDAVSPIFHQLDTDKKEVNPGGEVDGVLREYLVCQEDHLVLNPAHLTDEEISTVPCAGVTAWTALNCDLPSKEVHSALLQGTGGVSMFALLICLARGISPIITSSSDEKLNAIAKLGQEGEIRTINYKTHSNYDVEVLRLTDNVGVDVVVNNVGITSIETSLRSLRRRGTISLVGFLGGMEVDAQPHIYEGILLKSCTMRGIAVGSRQDHQSLLRFLQERDVYLKTMIGKIFPFEQASDAFELMMSGSNVGQIVIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGT4</accession>
    <name>W3VGT4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGT4"/>
    <dbReference type="HOGENOM" id="CLU_076902_3_0_1"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="142" mass="14873" checksum="8F3053E989F051F8" modified="2014-03-19" version="1">MSERGRGGRGGAPSQRGGPRGGGGRGGNSGGRGGGRGGHNSSERPASERPKKEAILDLTKYIDTKIRVKFAGGREVFGVLKGFDQLMNLVMDDVHEALRDADGNVGEKTRNLGLVVLRGTALTVINPADGFESIENPFAQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGV8</accession>
    <name>W3VGV8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Flap endonuclease 1</fullName>
            <shortName evidence="14">FEN-1</shortName>
            <ecNumber evidence="14">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_04651</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
            <location evidence="14">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
            <location evidence="14">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="14">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGV8"/>
    <dbReference type="HOGENOM" id="CLU_032444_2_0_1"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000066">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="335"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS60745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="373" mass="42298" checksum="168E70CF37F781E9" modified="2014-03-19" version="1">MGIKGLTALISDEAPGAIREMEIKTYFGRKVAIDASMSLYQFLIAVRQNDGQQLMTESGETTSHLLGFFYRTLRMIDYGIKPMYVFDGTPPDLKKELLKKRFGRREEAREQEEEQKDVADVEKMDQLARRQVRPTRQHNEEVRQLLKLMGIPCVIAPSEAEAQCAELARAGKVYAAGSEDMDTLTFGTPILLKHLTASEQKKLPVHQVDLPKALEGLQMDMPQFIDLCILLGCDYLDPIKGIGPKTALKLIREHKSLENVVEHLKEEAKKSVQIPEHWPFQEARKIFEAPDVQKGKDLDLKWEAPDVEGMVKFLCQDKGFSEDRVRKGCEKLQKSLSQKQQGRLDGFFTVKSGAPAPKRKAEDDKKTKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH65</accession>
    <name>W3VH65_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH65"/>
    <dbReference type="HOGENOM" id="CLU_852573_0_0_1"/>
    <dbReference type="OrthoDB" id="10256880at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="333" mass="36867" checksum="8E16547E8E7A5F32" modified="2014-03-19" version="1">MADSLQRLQARFQRLLLTNLAGIRALSTLPPGRRGAGPLVYQPRLISATRRSGGSRLLSPHPRSMHPEQRYRREQRAAAFLESVADVAHGTDDEWIDEDLQRAPNRRYHERSYADAVAASERQALLAVLQGTIELQQGTIELQRATLEFVQSLARQPRESVLVAALRKLAEWPGTFYRALVRPAIVANLRWIGAVPRQTLGKVVRAAASAYVSAVTVGVRTRARDKTIGPTPKATPRQKARSILGIAFALGSLHTLRPYIRIFSPDFFAPLLSPPGIEPMIGVLVHTASLPLLLASVATAKYFARRLRTNSRDGSPRKRSSRSTRQESSRPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH87</accession>
    <name>W3VH87_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH87"/>
    <dbReference type="HOGENOM" id="CLU_021160_0_0_1"/>
    <dbReference type="OrthoDB" id="3363896at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="718"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="759" mass="80190" checksum="06DA1F649FB32175" modified="2014-03-19" version="1">MVARQKPPTAAAYSASYMSLAVLSLLSSAGFSRSSAGAADLLSEVMQRYIQLLGSTCVQHANHAGRTVASPQDLRASLEHIMGGEPIEELLDWAESEERLEHAQAQPTGANGTHAAAQSSTASALLDPMRGQDLVRVLNTGRVAPSPDDVERIHFGALPAKQFEQVAAESLIREGLINQLVWPAAQASSQESASSDELVFSDVEDAHSEASDSEQAANDPFSSTAGHRPSKRRRVSVDESAQSRRFGDAVIDYVPAYLPLFPSASSAAESPEAPRGSRSEEVATGSSTVKAEVAPVEVDPEHLLEEQKRRELAQRKAEEAAAAAAAAEAEAAKKEAAEGEGEGAAAVQKTAEERAAEAEKAFEALQARRVLRDSWLEMVPYDASTLAATYGKAELRDLEHNVAAVLGDASIASIGAPTSSLRAFAADYQALVEDSTSSGSAGIYLTPSAASYQDALVKRRRLAHALADASRYAPNDSLYAAVAARPSVLPFVPGPSWLVSTLPPPTLYEDNIEVANALSAPVLTPLRPQGRPAALIPPSGALVPTLGHRHPSHLTTGARVVASAELLKRVSRYDDPIPILDDKHAERFFHGVPASRDLLGGSGSSSDLSSNISSTRSSGGGGSGSGNSTLRPALEKLVLQMREKEAEILPEEDKEELQRRQQELQLQLQAAMASEGGAKDSVVSSGLIADSYASRIRNGNITMVHTWDWTPRDAYDTGLPGKKVRNPGSRGVGPVALEKRTRTESATSDAADLAPSAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHJ4</accession>
    <name>W3VHJ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_05789</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHJ4"/>
    <dbReference type="HOGENOM" id="CLU_010104_1_1_1"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="15"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="249"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="178"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="407"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="588" mass="64860" checksum="1C0CE59CE76599D6" modified="2014-03-19" version="1">MFAAKNPFEDIVANATSDELTAENWELNLEVCDKVSSGGETAARNCIAAIQKRLVHRNANVQLYSLTLADAVAKNCSLTAHQELASRSFTQTLARTCLDRNTHAAVKKRCYALVKEWAGEFDDESLGLMKETYNSLKSQDAVQEEDSAPKPPKEPTSEQLRAEDEELRRALELSIQDQGGRQAWSAYNSQQPEASGSSATAASSSAIQQQQQQQQPPAQSTAPSSHPQPSQLNVATQPNQSTAAPPTPAGASRVRALYDFAPTEPGELAFSRGEIIRVLDSVYEHWWRGEVRGETGIFPVNYVEVLPDPSPAELQREAEMEARIFSQAADIDRLLNKLRSIDPARDNLAEDEELQELYQKSLAMRPKIVKLIDRYSNKITELKAMNDKFVRARGSFDDMMEQSLSRYNPAGQSSQDYLRPRPDLQQHPSASSADYANQNGWASAQAYSPHPAMPASNTHDQSQYPYHTQPPNAYPQSSSARPADAGYAPTTHASPHPQQQPASAYQSMHHDQQYSSVPQDDEKRRLFERARAESEAFQQQHFQGASQPSGSSYAGAYPSQPDPSALNQQLGNMNIGSSSGYPSQPIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHL8</accession>
    <name>W3VHL8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04967</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHL8"/>
    <dbReference type="HOGENOM" id="CLU_030471_1_0_1"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="465"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="579" mass="64576" checksum="E895C12E1F2487DB" modified="2014-03-19" version="1">MSLLWSAPAACSPRLSASCLNAVQGSACTASFLCHARSFRANRRSCSLASASQECSQGPHALTRQLAQELSLPLFPASGKQLHLLQDPSHFYETLKRKIGQARSRIFLASLYIGKEEVELVQALEQALRRNPSLQLTILVDALRGTREAAPTPSCASLVSKLHAQFPDRVNIRLYHTPNLKGLLKRIVGKRFNEGWGLQHMKIYGFDDDVVLSGANLSRDYFTNRRDRYLLVEDHKDVADYLDSLVRVVGQFSFKLESSPQEAGSSAEAAQPDWKLVWDGGRDCLNPEGQGVPASYAENGWSGEASKSLETFTRRWQHRTANTIGGDSDAADTLLLPLLQMGPLQIRQETQAIPRLLEVGLQASDPEKQPATLALTSGYFSLYKPYRKLLLRTQAAGTAIVKIICASPEANGFFQSKGVSGWIPDGYTWYEYQFWTALKRAKRLLGQNNRPHDQGGVEILEWKKEGWTYHAKGIWLTPSDATFETDLAKPASSATADVAAPTLVHVGSSNYGSRSADLDLECTFMISTSSRDLSLRFKDEFETLRRDANDVVNAELFQRPDRKVRWRVRVAAWILRRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIG1</accession>
    <name>W3VIG1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIG1"/>
    <dbReference type="HOGENOM" id="CLU_189343_0_0_1"/>
    <dbReference type="OrthoDB" id="3146826at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="87" mass="9192" checksum="4FC9D1D448303B80" modified="2014-03-19" version="1">MSAQEEQIPIQDEGVEDTNVDAQAEDEVAASGSEQKQLNAEASELDESNIIDNSPGVSTRGAKVDATKQEREVDEAVAAAEKADEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VII3</accession>
    <name>W3VII3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VII3"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_4_1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="59691" checksum="861E5ACE4164F6D4" modified="2014-03-19" version="1">MADDIKKDPSVDVETSTYEGSDKLEVEITKVTTTGTVQLTAGKIVYIPAPTADPQDPLNMPVWQKIMCIVNLSLFSVIGLAYVSGLGGVLNFYIPAYASIGKTYNEVGYMLTLPNLTMGVGNLIGMPLAVAVGRRSVFLVATAIMVVAIGLCAGAGTSASHYGWHLGARLLLGISAGQSEALVPMITQEIVFLHERARFLMIQQTIQVIAVTVFILFASPIAESIGVQWWYGIGCCLGGFCFVTSFFFLPETKYYRPQSSYQENADGAQQDSRDGFRIHTERPELDYVNYEPRTMRSNMRLWVGKPEWGKAWVVFRDSWTMLLLPGILWALLINGITLGANITIGLTYGRLVGSAPYSWPSKTISYANTGQIVTSLVALPLFGYGSDWIIKWFANRRGGIHEPETRLIPLAVPLIIGIFTAVLYGQGATHPDKYHWMVYVWAIAAEYLVFVGANIVAITYLLDAYPQRASSVLVIICAFRGILAFGVSYRAWDMIEALGYDGAFNMFAGLTAMTGVMAIGLFIFGKKIREVTGRWVSVSDKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIL8</accession>
    <name>W3VIL8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIL8"/>
    <dbReference type="HOGENOM" id="CLU_031758_1_0_1"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="504" mass="54315" checksum="36B094E6D28DA7A5" modified="2014-03-19" version="1">MSSPTPSLTVRNVRLPPAAYRTLSLDTDAAPLVDLEYTASNDTVEVHLTPHHASVEQRFDPDRPFASTIRVDPTPGECHSVVQEAGQRRLVGRFPAPTPAPGSAQPRCIDARGSLGIPGGLCHPHIHLDKCFLLDRCTLSDGTFNEALTATADAKAHFTHDDLVARGRRLIAASLSHGVTSMRAFVEVDPTVGLRCVEAGIALQSEFAGRCNVQLVAFAQDPLFYPDAAKQQHMHQLMRQAASRNEVGVVGSAPYVESSEGGAMQHKTQQRRNIDLVFALAEEHGKHVDFHLDYDLDPPGSAAEGKEAMLPYVLTLSRGRSWDVHGQARRVTVGHCTKLSVYTDFDVAGLGDAVEGVSVVSLPPSDMYMQGREQPYASRSRATLPLLELHKTLRLNWAMGVNNVANLFTPQGDADPLALLPCMVGVWQSAKPHDCETLLAAVSTAARYAAGLNSSYADAEVWADLTLLDGASAVQDAVCAPPFGRTTIANGSLVAQRTIHSTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIY0</accession>
    <name>W3VIY0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIY0"/>
    <dbReference type="HOGENOM" id="CLU_392353_0_0_1"/>
    <dbReference type="OrthoDB" id="3360632at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF671">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_75, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="87297" checksum="306C85D6FE965E76" modified="2014-03-19" version="1">MKELSSSDPPAANQYPTVSTQPSHLSVHHSHPHDDEAESSRRSRAPSSPFKDDDSAPDSRSYVARELLDPDELEEGDSDTASEFDAFLRQGRIDVGQTWDDSSEDEDAVHPLHQDRTLPLSATGDTAARRSRRANKKKVRPESYLQSLRPTREHRKAWWKLLTNPGTPASLSAPHVSANLFSASLHPAVLLSMPHYFARTGVLFGTVALVVVATLGGVGGGLWVVLSRYVNGSSIEAIVGASFGRYTPWKGGLGRVVSGLLLALYATGSAIIGYFALADLLLQVFFNYAPRGVPLHDRAFVTLVVGGLISVPLVIFPLAKRNVIRLNTFFSLTFYPIIVTIILVKIYTSTPPVALTGVPSTSGRPVGRDEWPNINPLHPPSVWAPISLLPLLTLSACPLQILAHQRSLRRIGTSRSNVKAFIGAQAGQVLFIIIMGILFGVVAGVNGVQGRLRKNSHPNLFASLPNDDDLINVARILFVAILATHLAICLTTARSSWGRLLRQLNIHPLRRRQQAIRLPLDEPATSSPLVGGTGGSMSHANVSNATHSGEEISQIGRWKRKWGKPARNALAGLLLWGVTAASAFLSGAGGFRRTEKAGEEARFTRASEVLGLMGAGVGFVMPGLVWMILFHIRRPRAILPPFASELGRTASAYFSGPLSMLARNRHYLLGGGRQNEDGERQPLLAGADSADQDHNDGASTSSATARPRAPISDAASAVSGLHSHRSSRHVPPASLDQDSASIPSHLTEQTGDDRDEATTILLARKERQLQRRTRGKRIYQDVIVFAAVLPLGFALLVLGAIELQRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJE3</accession>
    <name>W3VJE3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJE3"/>
    <dbReference type="HOGENOM" id="CLU_015935_0_1_1"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833119" description="J domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="427"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="544" mass="59319" checksum="A3E878E5E2BA35DB" modified="2014-03-19" version="1">MRSSLLPFLWTLCIALGLTTSGLLVHAEGVASAIDPGLANQHLTHANAALQSGRYQEALSSFDLALQADPSSWLTYYRRATAQLSLGRTSAALQDFQSLLDLNPKFDKAYLQQARVYLKEGDHEKAKQALDTYDKVRADNGAAATTEGASVRSKLTLVQASLRSLQQLAKELDKAHAQSAKGKGKQLDATKTMKGNLEDAMADWTRVVHLSPSPFLLRRLAVLSYFVVSEPGSQSRDAGLHHLKACLHSDPDNKACARLHRKVKALEKSLKKARNFHNSQSYRAVLSALKGGKVGGPTVVDEIKEVIVSATQVSPGDEEALIPATYQRDPVAESGLLHELYVMYCKAHTELNAMDTAMKYCELVLARDPDDATAILARAEVALQNEQYEDAVRDLTKAFEASGRTDRAIHQKLQTAQKRLKLSQSKDYYKVLGVKRTDAMATIKKAYRKLARENHPDKGGSQEKMAAINEAWGVLGDEELRKRYDAGDDPNDPMGGQQGGYGNPFAQGGHPFEMFFQQGGGGGFPGGGSFGGFPGGQQFHFKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJK5</accession>
    <name>W3VJK5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Muskelin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004210_0_1_1"/>
    <dbReference type="OrthoDB" id="10052615at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010565">
        <property type="entry name" value="Muskelin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06588">
        <property type="entry name" value="Muskelin_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Muskelin N-terminal" evidence="3">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Muskelin N-terminal" evidence="3">
        <location>
            <begin position="223"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Muskelin N-terminal" evidence="3">
        <location>
            <begin position="350"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1319"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="738"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1319"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1444" mass="153774" checksum="CC3939AF39CFB578" modified="2014-03-19" version="1">MPGRSAVEAGLASACTDRQMCRHRPPRATRARAALAAPLRTTISPPRSGVDLAFTPSASPLLTRPRAVHVLSRPGHAPSCAHTTMSSLAPPPDASDAITPLHQLLGSPNVPLKYSIAQASSWSGTYHPSNILHNRPHEMYSRWSGSSQHAVNSASSSSSSTGTGTGTGINPPAYLSQSAGTQSNTAAPSSSAASAASNPASSPSLSAALPPLASHSRRTASVPVMSNAAASTSGNVQKQYIILKLDKPSVVRSITFGKYHKPHPCNLRDFKVYGATTIDSLLPTSSVHGRPPATKRLLRGGLKNDAIPESFELRWLEDAATGSGSASSIDGAIRIPADGEPDRRSATNALVNTGNAVPFAIRYIKIVPLAAHTPNYNFSIWHVALAGVSDPALVNRVARSYDLHRHSSTTRLILKHLRQYGHHTAFQALLQSSRLGPPVPAEAAVPLQKMLPYSPLRPFEHPLLTSLFDALVRRGNWDEVEVCLNRAAYGGDAAAVQSAANSGSNTPLSPSTANLSRSGVWTQPWLKSMFSSYISRQIPKASWSHIHPSAPASLPSTSPYHQSAASAPASAPASAPASTPIAPSGRGGHAMVFDSDKGIAYLFGGWDGKRDLSDLWAYHVSENRWRLISADTQLQGGPSPRSCHKMCLDEKSGCIYLLGRYVDYESANHAEPVPADSIAHPSRTTPAVSTLPVTPSSSTARTTRANFLARYPESIARDIQMILSDASADTDDIGTEGAGAAAAGSTPAPPSLSESSPLLAGSGAGSADTNSRSPRPSTRTHSGARTDSQQRTAAPASPPGREADFFRFSTRSERWERLSADTHADGGPKLIFDHGLVIDAQNQMMYVFGGRVTDSDPTKFEFSGMWRYDIIQRSWTFLFDDRTSNGAKILSRSGHSMLLDSGRPGASGMSPSHTRQIWILGGQRGASATFLADMYTYNLATGAVREVSRNTAHNGPEAAFTQRATIDVAAREISVFIGLIGGRTERKRSAFWIYSIPRSSWRKVYEYEGGISSEFASDTINSGGAGGGMGAGLGVDEAMLGAGGVDGIDFDGELEGDEVPESGPLQALPAYSDDMSADEEMAIDPPANSWTAYTGQNVDASGTGAPAFATARSPHASTPIAGRSRADYGPGASSGMHPTEPQPRYATQLVFDDRKKVYYLHGGNPEDASDRSYRLDDFWRLTLLRPTPGEILRRAKFRVRRQRFLEMTRNLARMPNDSDDDFGVSAPSAGVASVDVQPQPQPQLGLEALMYLQTEVGAVVDHSDESESRLFRRLMSHLLSAETSDWTARAPALDASADEALSPLRGEAASSVVGGAMFSSPLNPNPGSSPHDSWGAAGFKRPRDEAETEEAEMGSSVSSLMSAEDGSETMLSASQVLQHRLKRSAGTAAAPKLPTLSVRDDEGRPSALYVERTRLFRELIEYFNPELVEPRAELGGCIEAALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJQ2</accession>
    <name>W3VJQ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJQ2"/>
    <dbReference type="HOGENOM" id="CLU_014455_0_0_1"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="386"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="731" mass="76066" checksum="4423883305965D23" modified="2014-03-19" version="1">MSGAASTNPALSFGPTGPSSMASSTFQSPDPSSSSAAGYNAVGSFPAGFGRVKADPSSYSYDEQAPRSQQHGNYTHHDLGGAGTLAQTQALGGFNPSTNQHYADPIRSAAAGPANYVPGHTRHQSLNSGVSQLGLGGGSSAYSFGDVNASQYNNYNLVPAQRSPSGRSSGLPAETSPTRTRLPSVGYSDPRTINRPPSRTVGLGVSVTPGASSDESAKVETGSPRSLKRSADPLEDLRSSSDHAQLRRPASFPVLGAGGSGMYGRPIGQDARNAQSIGRRTGRGGMGVPGQLTPGRSNAMLPGLGGGFYDSDARRESLGSNTTMQSPGAYHGGSGSSDELGLGGGGIPQLMRATQILGSIPPAPAMASHDPMYSPPGGAGGGAPRARLELHGNLNDMAVGWSHDEWRSGRRLVQFWRRQEGTTIHATFRPILPSQYVPNSIVISCIFREDKNECFVTSVDTIYLLEALVASRFTVEEKNRIRRNLEGFRPITVSKNKRECERFFKLIMSFPNPKPRNIEKDVKVFPWKVLASALCKIIGKYSASYEGGPPVLSDLGPDASFGGAMGGSLSSVDLSGGHYRDVSYPSSSPSIKDTRLPGAFDYDRQGGAAGAYAVSNPGAHHSAGYGGNAWNMGSQDMAFNAPGAATGYAQGPGVPFSTGGGGSHSHTHSASSYDSFGGGNLVQNPAASDAGNMYAQQPQEAYSATAPPPHSQAPSSSTLAAATGDYYADNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKL3</accession>
    <name>W3VKL3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002738_1_1_1"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="460"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="659"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="899"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1148"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1379"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="921"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="976"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1155"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1223"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1384"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1418"/>
            <end position="1427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1497" mass="161951" checksum="4EE97B437739FB96" modified="2014-03-19" version="1">MSAHEQHASSGDRTAHHSVRSWLRSLLQKPSDPLADVIAPSTSLTAPAVPPGPPSASGADMISFHHTMEDHDQARFLPPPRSFSGGSSTGSLSYDAAARRTIAQPIPTPRLGAARSAQTLSPPPSTGSPPEPSASPPRSPGIARTLSVGVASLTDRLHHQRRASETYRRMRSGSTAAETDVSHPPPSLSRSIPKTVLPTAPLVASPPPLAEAEEASFLPLAPTSSRLSSNEEQPDGRGPFHAATGSGDKTHVSTASLVSLDPLEASSSITRDSSQVLGRFGPLSPANPASSSADSSSELLLPEGEKMLKVTHKKVKPRIFKLDPDRGQILWESKKNNRVNLESIREVRFGPSAASYRTSLNISSAHEPRWVTIIYQNGGIYKALHLIALSDASLARWRTSLLHLQSLRRELIGAVGSSASIEHRRHLWMRHHWKDADQSNDEKLSIDEVMQLCRRLGIESNKTHLRRCFNLADWRNRGYLDFHDFQHFVSLLKQRADVQSIFAAWADVPLDRGKGAATEPAAPIPGQVAAAELSDSVQRPDSANVQRTPSEATLAASLNKVTLAAGPEPCRTRAISIEAFRRFVRDEQGNRHFSDSQIDDLFRRHCNSRLSATLPPDAPLERVQMDYDGFLDFLSSSDNPPLVDQLPLFATITAEPEASCSTRKPVSSSSADAALQADATQNQQGNPAQQQQTPSRAFADTTEELIAAGACDSTANTRKVAAHLRKSTVHHDMTRPLSEYYISSSHNTYLVGGQWKGDSTVEGYIRALLQGARSVELDCWDGPNNVPQITHGRTLTSRVPFQDVITAIARYAFVTSPYPLILSLEVHADPPQQEVMTRILKDTLGEMLLTQPVGSRTLPGAEDELPSPEELKFKVLVKAKNISLAESQRALHDKRQAGMLGSSAQRKDEPSVVPVTVLEPSTSATDTTTTTDSEIESRLLSAKQLVRRVTRRAHRGDRSTANPAPRRSSEGLDPLEVDRDSRDEVGRSSSKQSKKMMSAALASLLIYTIGVKCRGFNKKESYATQHMVSLSEKTALKLIRDPTSNEALVKHNRTHLTRIYPSMTSFARLHASRNFVPLDMWATGCQLVALNWQTTDLGFELNQAMFSRNGRCGYVLKPVALRVKDKTKSVAGKALRFSLDLSIVSAQQLPKKSRSGKERDKDKDKTNASEGRDPIDPFVVVSLLAPDCWGKQPRGLLQKSAVRRVAKSAPLQVDGQRQDSGATTSSTQSSSQTEGVDALIQDSGHRDASASAGQLDGKAQLESMGSCSQGLDIASSTNESGRRASLSSVWQTSALAPAQLLRTPTVRSNGFSPEWHTDMSLLIDMPASANSEVMALVEAAQASTDSASLDHAELGRISRGLLDLCFVRFEIFDDDLEGEDSRDIAPATSPTPPSDSASPPIDATAKLALDTAADPGKTGSGARGGPGSESSVASSTSSIDADSVAAYAVSVGALQQGYRHLPLYDHQLSQFLFSTLFVRSRLRLVGIVDAPPPSKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKR7</accession>
    <name>W3VKR7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKR7"/>
    <dbReference type="HOGENOM" id="CLU_375576_0_0_1"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="153"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="11">
        <location>
            <begin position="561"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="749"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="90910" checksum="A3A60F64C17D5DA2" modified="2014-03-19" version="1">MHQLSALSTHIVRAKPLVILTASTRPLRQASSFSLICARSSTKGNTFGSRSTSASAHSPAVRTLVNASMPSVAQLRQPSPSMLPPAKRAKMELNTESKSHVAAAAPEIEAVAADSTSYNDVPALPDNAHHHVDDLDPIPACTSTLTFQNGIFLAPMVRIGTLPTRLLSLEYGADLVWGPEIVDRAIIGCERKVNPATGVVEYLKEHKQIFSCHPIERPYLVYQLGSANPDLAYQAIKIITQADDVAAVDLNCGCPKPFSTHAGMGANMLSTPVLLCNTLKAMRRAAPPHVAVTCKIRLLPTQEATIELVDKIVRTGAIECLTVHCRTKDMRPREPALLHRLREIVDHVNTLAAQMGRTIPVVCNGDVWDAVNAPRIKELTGVTSTMVARGAEANPSCFRPQGSLSIPDVIAPKWVRYSLALNNPIGNTKYCMAQLAFKPAESVAKDAGAKAKPMNKKQLSALRMGIAQAKTHEELAAVFKIDVDQVRALSVDDEILSDLRTALSQRVSHRSASGGGFDGERLGAVLNNASGGASQQVGQGASDGHASGDGQKRATDNSPQPEWKELLATSVSDNIKDEKSILYYAFSTVEPPSSVHDAAKPHVRYVVHRGFVNEQRDGDRPGGIAPHNPSFGSSPCLLTTTDVRTPKVQQLTSQSSLRAHGPDGSRGGECEIAWWIESAQLQFRISGTVHVLPTPGHPLRSLFPFERLSPPRAPGSEAIDAFDWDKERKRIFDKLNAGLLASFCRPTPGSAHPNADSLHQAKPKDDTSSPWPLELPSPGKEENEEQKKMLEESEKNFALVVVEPYKVDLVNLADDTRTVYELQPGECAATGRWTARRVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKT6</accession>
    <name>W3VKT6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKT6"/>
    <dbReference type="HOGENOM" id="CLU_1834900_0_0_1"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="144" mass="15094" checksum="73D778ECD6CE40ED" modified="2014-03-19" version="1">MSYQARPAGSAPSGGAGMGGLATRNPVMEYICADCAATNEIRPREPIRCRECGHRVMYKKRTKRMLHFEAPAAVGMHGGPAESNSAAAPPLVRLASHPLYTLASASYLATSIQDSTGALPPPSTTLVSGGTMFPGIPIRSKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKZ8</accession>
    <name>W3VKZ8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKZ8"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="543" mass="58691" checksum="24DC6F7784538981" modified="2014-03-19" version="1">MSAKTPIEKAATEELSDNPLAPVETRMSDYVPPVMSTLQRRVIMVSLCLTLFLGALDVTIISTALPTIARELGMTSQQYAWISSAFTLANTTSTPVWAKASDIFGRRGIVIASAVAFMAGSLICALARDGTMLIGGRVVQGLGSGGSLVMVTIIIGDLFALKDRAKYYGLTGIVWGIASAVGPVLGGVFVQTIGWRWCFYINLPFDGLAIVVLFFVLKVEVEREPVMQGLRTLDWTGLVLIIAGSILFLYGLEVGATNAKPWSAPIVVCMMTIGLALLVVFMVWEARFAAKPVIPGRIFSKATNMAAFVLACLHSLCFISFDFFLPLYSQVILGLSPLISGVTLFALIVPLSCMPVVGSIFIRKTGNYVFLCYLGATLMTLGSGLFISFKTEREWSKIITFQVITGIGAGLLFQTPLIALQNFLHQADMAAAMSAYNFLRNLCTSISVVIGSVLIQHSLPAGSSITSLHSTQETGAGHETVKIVSKKQYMTGLRNMWIFYTAICGIMLAACVFIKQKRKVDKAEEASVESEPEKRKSIEEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL29</accession>
    <name>W3VL29_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL29"/>
    <dbReference type="HOGENOM" id="CLU_032406_0_0_1"/>
    <dbReference type="OrthoDB" id="3067443at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055592">
        <property type="entry name" value="DUF7168"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23771">
        <property type="entry name" value="DUF7168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="2">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7168" evidence="3">
        <location>
            <begin position="199"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="566" mass="61488" checksum="791093A1EFCC3657" modified="2014-03-19" version="1">MPTLARSRLDVADVKPRVKPEPDVIDLCDSDDAAPTPSSRPEPKSAPVRSRRKVADRALLKYEDDDSDATDGPNRADGDGSEESDDDFRGSKRKAVKKGRAASATPGPSAHKLYAIARIATLATDGVASVSESEAKLAGVSAGILSRIQKSLALAKHPGTGEAEAQQALRLATRLMSSQNLTQADLLASSDAEANQARAGMSIVEIVSQTSASPRNESWTNQIAVAVNLFFDVKAYSTSYANRSRLSWTFYGLAVNTVAAAHAFEMVHNQVLTWAYEKAAAKLVSGKTGKNSYCQGVAAGLIALAKKEKKEEMRLAIEAEKKRLDDAHKTEQAQVKKEKERLRDPPQPASVKPEPSEDLSSQSQSGSRSVKLEDVVDEQDVKPSRNGVKQEMSDVDGAGYGRWSEGYGASAFGHTKLEDGMDYDDDDDDAATDRFYDMDDGAHGSDPHGALGEDIKPHFDEALERDIIDLTDDLDTAAASEDIKPKLEPKIEADNGADGAGWHSSGQLMRFRQDAEKIADDYLASQHSGLKLRKRAKTTYKRDSQAFEQGRVDARKIDVKRKRIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL41</accession>
    <name>W3VL41_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04514</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL41"/>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_1"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="115"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="524" mass="56475" checksum="C3F64E8D99E85B2A" modified="2014-03-19" version="1">MASSLRSSTPSRMALRALTRTDAVHARTISTNVSKLSAASAPSSSSSSTATSSSASRGQARGYASPSSPASMATPIEVAQPDVRAGIGSKMGSGKNLLSDIIAAAPKHSTANRPIYLDAQSTTPVDPRVVDKMMPYMTNQYGNPHSRTHAYGWESEKGVEEGREHIASLIGADPKEIIFTSGATESNNMAIKGVAHFYKSKKNHIITTQTEHKCVLDSCRRLQEEGFEVTYLPVQSNGLIDLKQLEDALRPTTALVSIMAVNNEIGVIQPIKEIGHLLKTKGAEIAKQSGRGATKPFFHTDAAQAAGKIPLDVNELGIDLMSLSSHKLYGPMGIGACYIRRRPRVRLEPIINGGGQERGLRSGTLAPQLIAGFGEAARLAKQELAYDHAHITKLSERLRNTLEASITHVLFNGDPNGYPGCLNLTFQYVEGESLLMALKDICLSSGSACTSASLEPSYVLRALGLNDENAHSSLRFGIGRFTTEEEVDYVADKIIRVVNKLRDMSPLWEMVQEGIDLESISWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL83</accession>
    <name>W3VL83_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyl hydrolase family 30 TIM-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL83"/>
    <dbReference type="HOGENOM" id="CLU_458635_0_0_1"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000412">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="7">
        <location>
            <begin position="156"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="609" mass="65854" checksum="ED7B53D817D5E118" modified="2014-03-19" version="1">MPLFGSGHSREDSASYADKPLSSGPASPMLPTSAPRSGQHGKPKNKVAAWWRSQSRTRKILLIAAVVIVLLGLILGLALGLTLGEEKEDSNPSTDYVPQTISGSRSSLLADGYWYTAPSNGTNFNWTASTTQLGNYRADSTGVDIIINTAQRFQAIDGFGGAMTDSSAYLLTRLKQREAGLYSRVMDFMFNNATGVGITRATLGASDFSVMQEYSYIAQPPDFAAAANELNNAASLLSSFNVEGTQSSMYTLPVLVDAKKRNPGLKVILTPWSPPPFMKSNNTMNGGSLRDGFIPVLAQYYAQAAQAWSDAGVRPWAMTLQNEPSHIASYPSMGLNSTQQVQLAQELRSQLESRGLGSIQVWGHDDNYSGWQRAADIVNGNSSAVDAIAFHCYRGDPAEMAQFEGALRNGVTKNLHMTECTGTGNPSNRWSGMQGWLNNVYWPVGSQNARSIVQWNLALDRGYGPHLESAYCTSCTGSLVLSSQQKPADPYVSYNEQIYLTAHFSAASTDLTNVGGGQAYRVSSQQGTQYSLNRNDWQCLNWLAYAAPTTGTTLQNATTSNNNGQPTRRVGLVIANTCKDTKNVVVSSDGRRTTIPVQQGLSTFVWTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL92</accession>
    <name>W3VL92_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein sey1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SEY1</name>
        <name evidence="12" type="ORF">PaG_03049</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL92"/>
    <dbReference type="HOGENOM" id="CLU_011270_0_0_1"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="844"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="849"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="873"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="188"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="927" mass="102298" checksum="13056ED6ABDB50C8" modified="2014-03-19" version="1">MSDLPRQGSHPALSVPSDRPPPVRAQGQLLLLSSQKCRSRSIAPHTPVPVPCRPLAPGFPIPYPAAGYPQLIMELNVDSAKQLLAQSEQELQQAHAQQLQALQDEPITAATSAPNGAASHVAPAPVAPAPVAPAVAPVAPVAAPASTLVSSSQSSNAAGRMQLIDENQKFNSARFGPSLDQWGLADAGFGYDLCAVLGSQSTGKSTLLNKLFGTNFDVMSETARQQTTKGIWMCKGLKMNVLVMDVEGTDGRERGEDQDFERKSALFSMASAEVLIVNLWEHQVGLYQGANMGLLKTVFEVNLGLFQASKAKTAGAKDKTLLLFVIRDHIGVTPLENLSATIMADLTKIWLSLAKPEGLEASQITDFFDFMFTTLPHKVLQPAEFDKAVDALRTRFVDPKDPNFVFKTEYHKRIPADGLPHYLESIWEQVMTNKDLDLPTQQELLAQFRCDEIANAAFALFATSIKDFRKHIEGGSILDTLGADMALHRSTALASFDRDASRYHQEVYKRKRVDLLEKLNSSLSPFFLGQLKNLHRHMLQNFKRSVLDRMRTEPNYDFGHVVSSEKRTALAKFSAAANAVLLAETDWTVDEEVAQLDAEIQAISDTMRVEETKKMVAQIERTFKKNIGEPVEMALNAPGPEMWDQVLVAFRRTLEQAEATYVRKARSFNCTEEENTAALAALRRKSWLSLRAKVDEQTADSVLAARLRGCFEDRFRYDDAGTPRVWKPEDDMDGAFRKARDETLALIPLYARIEPKDPAVAVQLASTEDDAELQGAVDRGEEEEFDFAQTLVVFSEARKAEIGTRFRKEADALYVEAKRSTVSSIAQVPLWMYGVLAVLGWNEFMAVISSPVYFAFLLVLVASAYVVWRLNLSGPLASVVGAVGREVHRLADEQLRSHFGQPVLAQPVPATTAAQSTVAEEIELQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL97</accession>
    <name>W3VL97_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL97"/>
    <dbReference type="HOGENOM" id="CLU_011340_5_1_1"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="476"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="531" mass="59134" checksum="3EFE69A4177F43C8" modified="2014-03-19" version="1">MLDPYFERLAGVAGAPVDYIKLFCCLLSAFPLASAFVHLPSPALKHVYSMAVSFTFLVAILHLYSGFLQLLGSALITYAICWFRVGGRNMGWLVFGMQMAHLTYNHAVRKFGGIPLSTIEITAMQMVAVMNLTTFAWDCFDGQVRSEAECDDAQKKTRITKMPGLLEFLGYAFYFPGVLVGPSTRFSDYRAWSTGELFGTKGNISMPRGRVAAAVRTLLVGLGFMGIYSIFAPAYSYEKLIGLHGGLGHLKWWQKLGWIQVAGFMARTKYYGIWSLTDGACILSGLGYNGVQNGKTRWNRCSNVDIPKIELANNWKELLDHWNMNTNVWLRNNVYKRIARPGKKPGFKSTMTTFFTSAFWHGLEPGYYLSFILAGFMQSAAKMLRRHVRPVFFAQPNVANPTFSNVHTFSAGQLAYCTLSVAVSQATLNYAVAPFMLLELRASIAGWKAVYFYGHIVTAVAILAFQNGLGKALDKRSGRRRAKKEEGAARMASGFTTDADSDREELRRRNKKQVEDVSALAPVPDPLPETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLC7</accession>
    <name>W3VLC7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CEF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor cef1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03426</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLC7"/>
    <dbReference type="HOGENOM" id="CLU_009082_0_0_1"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="230"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="484"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="778"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="515"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="814" mass="90360" checksum="E542CDE26E662978" modified="2014-03-19" version="1">MVRVIIKGGVWKNTEDEILKAAISKYGVNQWARISSLLVRKTPKQCKARWYEWLDPSIKKTEWSREEDEKLLHLAKLMPTQWRTIAPLVGRTANQCLERYQKLLDEAEAHDNQPGSSSLALTGTGEAVPTADDVRRLRPGEIDPDPETKPARPDPIDMDEDEKEMLSEARARLANTQGKKAKRKARERALEEARRLAMLQKRRELKAAGITMKQKPKKGAIDYNADIPFEKKPLPGFYDTSAEASKSYSAPVGKTLQELNSRNGPDDGTKNKRQREADEKSKQNKQAASVRNEDQVRKLKEAEQITKRRKLNLPAAQVGQDELEAIVKIGQASERARSLVEEGSSDATDGLLERYSTLDSAQTARTPQVAANEDALMREARNLRLMSAAQTPLLGDANADLDGHQAASDSSTRLSVPQTPNPLLTNTLRDERGASADRAGGSTPLRTPLRDNLGLNLEDRSRAGSETPRDLKRARNLAQSNLRHALSSLPAPKNDFDIVVDDDDDEPEASTSGHQESDASTRQEDAAERDARMAREAAEEEARAEARRSQVVRRNLPRPAEVDLARLIAQVEAKYSERVELMVARETAYLLHHDVHVHPIVGGKHPEPESVELQAVSDDSLSAARELMRAELAGQLGFPGANDEVLRRLIAASLDDDDETTATLEAALKRGWAASRTDKARLEQDLSHARSSMAAAAQQASKGEKMLGKVLGGYKARSEALSATARETFKALEEAAISQHTFARLRRDEEGGRAERLDSLRREVERLDSRQGVAQGVFRALQEERDALQDECETLEMQLNMRRAEALNEAALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLI1</accession>
    <name>W3VLI1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04092</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLI1"/>
    <dbReference type="HOGENOM" id="CLU_004174_1_1_1"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000326">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="317"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="929"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="1079"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1211" mass="134771" checksum="AF244C45869A08DD" modified="2014-03-19" version="1">MVTKPSSHHHHIVTLSITLSSSQPDRSSKSASRRISLDSRTRLSCANVRLAAPPATTTTTTTPLRLFRSLALKPRPGPPRSLLSSRLLNTAVATMPPKDAAAAAAAAKDANAGPIQLENTAKRDFLQKLESESQAYWKQQNVFDVNAPTQDAGLVDMSPEEVRAKYPKWFATIPYAYMNGSLHLGHAFTLSKVEFAAGYERMQGKRALFPWAFHCTGMPIRAAADKLVREIELFGPDFSGYKDPADEAAAAADADVEPPAPVENTSSATKSNANNVAKATKGKLAGKDTGLKFQFQIMLNSGVPKEEIHKFADANYWLSYFPPIAKADCTAFGSRIDWRRAFITTDVNPYYDSFVRWQMNKLHAMNKIKFGERYTIYSPKDGQPCMDHDRSDGEGLGPQEYTGLKMELVQWGALAAPELDAKLQGKNVFFVAATLRPETMYGQTNCYVGPTIDYGAFQINDSDVFICTERAARNMAFQGITKERGEVKQLASIKGSQLLGTKIKAPFGLYPEVYVLPMETVLATKGTGVVTSVPSDSPDDYATLMDLRKKAEYYKIDPQWAAFEPIPVIRTPAYGDMTAETLVKQLKIQSAKDKNQLAEAKELAYKEGFYNGTMLVGSYKGEAVQEAKTKVRDEMIRANLAFAYAEPEGKIISRSADECVVALCDQWYMDYGEESWKAQASKLIAQMNTYGSEVRNAFEGTIDWLKQWACARSYGLGSKLPWDPQYLVESLSDSTIYMSYYTIAHHLQGGVADGSQVGPIGIKAEELTDEVWDYILGDAAFPADSSVPKAKAEVLRREFRYFYPMDLRSSGKDLIPNHLTFCVYVHSALFPEHHWPRAVRANGHLMLNGKKMSKSTGNSLSLRQSVEKFGADATRLSLADAGDGIEDANFEEKTANANILRLHTLIEWCTEVVQNKSKLRSGAKDTFWDRSFENQMNQLVQLTNEAYEKALYKDATKYGFYELQTARDLYREATADVGMHVDLVLRWIRTQALLITPIAPHFAEHVWSKLLGESSSVQTARWPAAGPVDHSIAEALAYVSGTVKTVRDAEILLTKKAKGKNAAPVKYNDRAPKECRMFVAKNFPAWQDKCVSLVQAHYSPDTGAFDDKAIREQLAKDGMLKDKKVMNFIVTFKKRIADFGAQTAFNRLLPFDEIATLRAAAGYFKKSMHFSQIHIYQIEDKDSYKDVDVDDKVLEAAEPGQPSFAFFNVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLJ1</accession>
    <name>W3VLJ1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLJ1"/>
    <dbReference type="HOGENOM" id="CLU_2795019_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="68" mass="7321" checksum="531B3E92AF06FB13" modified="2014-03-19" version="1">MYMLPTRIFAYNNSIPPLATSPRSAKNLASPSSPTSTLPRPELLVIAPSLPDLDVRAPLPFQDDIACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLV3</accession>
    <name>W3VLV3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLV3"/>
    <dbReference type="HOGENOM" id="CLU_007740_0_1_1"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000670">
        <property type="entry name" value="Vacuole-associated enzyme activator complex component (Vac14), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="6">
        <location>
            <begin position="724"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="917"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1093"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1106" mass="118049" checksum="791B29E115C5B3C1" modified="2014-03-19" version="1">MDAALQKALLDRVYDKRKAATLDLERQVRDCLARGDRARVNLIVQQLCSFLSASPQNVNARNGGLIGLAGIAIALGVEIAPFLEQIAKPVLACFNDPDSKIRYFACESFYNIAKVCKGEILVYFNETFDALSKLAADSELSVKNGAELLDRLLKDIVSEAAPHYVSQFQDISLIRAHQDAHDGFSGGAAELDVAREKAHQLDQQGTANNKVFSLARFIPLLAERMYVISPFTRNYLVSWITVLGSVPELELVSYLPSFLDGLLKYLSDPNTDVRVATANVLADFLREIRHAAELSARRQAFEQHRAERQEHRKRKGKQRGPAGAADPVTLKADTADEPTASAASEAQSRSASPSKSFRSPAPSQTKPRSDGATSPLPPPQRDGLPADHDSALATSPAPTQSHDNDAASGAEDEEDEEDDDEDDEDIWVEGTEVRIDYAAIVEILINHIGFPDEEIQATTLQWIAELLLVVKDVVVPFTPRLISAILPNLAHHSPAIASAAHATNVNLYRVVQDIPAPTTPPSTRAQTTLPATAPGHRSTGSVSSSRDRASAGSPTQHGNLSRHASISRPAASSSSGPLSPRVRAGTISGEPTAGIAGLSLSDDAAGTDRTSSPNAAADGGAVESDPFDYQTTVNALTLQLLDEHEETRVTALEWLLMLHSKSPRKILSMDDGTFPALLKTLSDPSDEVIRCDLRLLAQISSASEDSYFHAFMANLLSLFSTDRRLLETRGSLIIRQLCASLHTERIFRTLAEILEKDEDLEFASIMVQNLAIILITSPELADFRRKLRNLDSREGQQLFASIYRCWCHNAVAAFSLCLLAQAYEHASNLLTIFAELEITVALLIQIDKLVQLLESPIFTALRLQLLEPERYPYLFKCLYGVLMLLPQSSAFVTLRNRLNAVNGLGFLHSVPRSSYASRTSSKSVSTGSGGAGAGGGAGGAGASEIKWSDLLHHFRVVQNKHERARRQTALGATMAAGATPGGPDYAAPRIGSATAATASAAPGRRRVSQAATPTAAAGSLTPSGSAGRFGLGLSSGGTNARAPATAGAGTSSFFGIHLPSTGAAAGSNANAAGGSTARSSSPSTVRRHALGSNPASRSASKGSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLW6</accession>
    <name>W3VLW6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLW6"/>
    <dbReference type="HOGENOM" id="CLU_044153_2_0_1"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="99"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="466" mass="51258" checksum="C980928D74B0AB53" modified="2014-03-19" version="1">MAPVAVSASTLDAPAHASKQVAQDGLVRGDSNIAFAPASEPYQRRLKLVQNDPNEREITFPLIVRPVRTNGSTEPLTTPETVESVRSLAPAPASEYRPSRLQELMDAHGGAVHFKGLPIRSADDFSDFMHSLAGAPPSSADPGETRNLWHAHVDKGLMVIRHQMAPNVATANEGPPHQSIGSHNEYGLSTHYPSVIAFCCLSAPTSGGQTPIANSLALYDRLNSSVPGYVEKITRRGLTFVIHHPVAKVKDSVQGNSLYNPDSFGPTPQDKIDLTQLTEAEKRQLVEDNILDLAREGGWGQPTADEDGEGKLGAWHQRGFSWTWLEDGSINVFQRVPGIRVHPTLGRPAYFNNVGNRYAYSKQHGCLEPPHYSSEKNDFFPPPSFPRPLDGNSTEQDETIPLEWLETAHRTTEDLQAHVEWHQGDVLVIDNLAVQHARTPWTGPRKLVASLWDQPSYLAKHAPIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM61</accession>
    <name>W3VM61_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM61"/>
    <dbReference type="HOGENOM" id="CLU_385481_0_0_1"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="294"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="404"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="563"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="717" mass="77270" checksum="7B9353D32478DDFE" modified="2014-03-19" version="1">MTRDSPSAARSFATIAAVDMLVGTQAPSNARWAPVALKSGKMRHACELEGDHSSHKSRVAQSRASEPSNERLLAFRERPTLGTALRYRHGRRCSEAKRGCKSRIELSVNPSLSAPRINSGIASNVGRQRRNALARVLALIFQCLLPFRRLVRGTDVAAILPESDNDGVAVPMFPFSLRWIDLGYASHSYREIDRATLQSRLHSMLIGARTVEMVISCYAALFAELRNLPLSTIVNGSKELRPGYNGPAAKASMPGINGSIHAAASDEDYPSYDAEALQLPPHLLLDAFHGLNVCAPMVRYSKLAFRALVSRYETHITTTPMILAREFSRTEAARNSEFSTNAYERGTFSLVPGIAEGSESSQRRLAVASSQNTDTTSNAQDETSGEAEREKAARRARQGKQSVRVRGALVAQFASSEPGAFADASELIGLFVDGVDLNCGCPQPWAYEEELGSYLLRQPETVRDMVRAVKARMGEDFCVSVKIRVDPDLSLTDALVRNALHAGASVLQIHGRTRWQSSAGHPVDLDAIKFAVESANACGFRTAWGSRGGAAAQFADGGSGGLVPCVANGDVWTLDDAIKYRSHTGCSGAMSARGLLANPALFSGYDQTPDEAVELFHSLATSWGLHTALIHRHLAYMLEASFQSRAEAVYFNSLSGAAALTDYLADQGFLSTRSTHADPLAARFGFALASTPLAAARVGPQRMWPLADVLAGTGLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM69</accession>
    <name>W3VM69_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM69"/>
    <dbReference type="HOGENOM" id="CLU_826870_0_0_1"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="370" mass="41259" checksum="8509BA29521A91D8" modified="2014-03-19" version="1">MVDPVSYVKMFFRSVFSVFSPSTTTVWQNNIAYSITLHNPRVLLYRGPETYLTFSVYAQAYSAEARKQLEAVSASQIADIVKNTNVQLVQKGWIAGAVGWNAAGYLGVATKKGWDVTPAGRAGWKDTQAESASLSLQQQEDEDYGEKPQQRASNEYEMSTLSNNGSSASLDSQQTRHIATKRKEKIDKQIRTQSTSQDSSSTTRVLGTYKCRVPVETGDGYFRLWVTLPSVVRGQVGIGSPTFRLFSFSLTSASPRGAALLPVPVIVPELALRSVSIALTTLVYGLFPVAAIVDKLLPRWMSRRFINWIYNRVGAKGKTDQLRQKYNVDEKVEQAKQQVRKVPFASAGIRTDWDLHRDASRGRGGWAYHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM81</accession>
    <name>W3VM81_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02466</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224504_0_0_1"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000580">
        <property type="entry name" value="AGC protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="3096"/>
            <end position="3498"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="3499"/>
            <end position="3606"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="3815"/>
            <end position="3932"/>
        </location>
    </feature>
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        </location>
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            <begin position="1028"/>
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        <location>
            <begin position="1305"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1332"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1386"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1411"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1466"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1497"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1526"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1567"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1599"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1649"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1675"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1776"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1821"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1846"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1939"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1963"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2064"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2090"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2289"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2383"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2799"/>
            <end position="2819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2820"/>
            <end position="2829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2883"/>
            <end position="2893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="3054"/>
            <end position="3063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3276"/>
            <end position="3292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3299"/>
            <end position="3310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3526"/>
            <end position="3542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3549"/>
            <end position="3558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3574"/>
            <end position="3587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3659"/>
            <end position="3670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="3671"/>
            <end position="3680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3699"/>
            <end position="3710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3719"/>
            <end position="3729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="3945"/>
            <end position="3961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3980"/>
            <end position="4001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="4014"/>
            <end position="4027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4042"/>
            <end position="4053"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="3865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS62728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="4068" mass="424179" checksum="4FA60D08910B5584" modified="2014-03-19" version="1">MPPARLTTLVTPLIRSSSLRFMLGGAASSWLHDLPWLARHSHASPVHGIHRGLMLRFGGMDRSALASTLAEFRAPRALAFLSLLLAAAASALDLANFAGAFWLAWAPISHTRPLACVFLSATHFTDPFSAANRTRISPGASDPSRLGASSFAGDAEAYDPKSSPSSTGPSPSPSSSLSQAAATHSRRSTLDQLQPSTSPTSPPSAPGKHSRSDQSPSPTRSFKHSRIASDDHSPPSASASATTPAEPVATPSAAQPPPQSHSQGASQHPASASSVHASTSPPAANASLSTSSPGFSLSPPSAAAYKALGRSSSKRMSFDTAPSFSSPLAFASILPNDDDINDDEAQLNHDDAPAPASATWMPRARGSTSSSQGSVAHHLSPTSPSSISSASSSQPGRRQRRQTGSDSAASDTVDEASQRSSARRDVSQTAAGATPTTAEGAAAAAATGASPLARTSIRLDRERATSNPLHRAVTGASRLNRTPSRHSPFQSFGVVDDDASSVASDDVATTGSNLTRKSSVTSSTGSMGPPAVPRRIAAGATGSPALEPVDRPASTIAMGKRKEDSSLGLGIPLNPSPLSSGSSVGLPASSSFHSGSPTLGWDTRGARSSSGAFAPSSFGAAAASTTPSNTTAGGSAILHSTRRRRMTSSSLSSSAHRRARSLGGVLLGEGAVSPVGGPDGVDPNLIAAIESGSPSIPLPVPIPNAPTSHRSGSVSSSGTQGAASSLSSSSLAPSSVPFGSSLVARASLHRKRNSQVIDDDDLPRGDSSGSQPSPGYTRSRVRSQTLGVPPSSLAPASATSPAEAPSTMLAPSPSGKSTGSAGLADAIRLQRVPTAVRLAGDLFVPASPSPRTMPKSASTASMESPLGRWSSHNQHGGSLALGSSGQGHGLGLGLTSDAPSASAQSSRLNVPQTPNATRSNSPLASEYTYSADDAAIASGRTSPAVERLRADGLAMPGHDSRGQPLSVSIPIGRDYGPTASLPGSAIFGSRSPGVPPTATDHLDVPTSVPRHAGLSASTSAYSPLLSLGASSAQTSPTTTRRPTLSPSRSSTQRMSWGAQELFDSLVETNEASEDGRSNTPVSSDKPAPWIASTQDAPPRTSLAPAAATISQRRATQSNLSSSFGSNALLAIPPPARRVHRPSDAALFTPGGISPAASNQPLSGTDEYARIIIQSRNAKMQKWRAQNPSRLGRGDAVAAAAPGRAGQDRSQDGQADGALFGQTSLGRRGTTIGLQRDASLLDAMRARRGSAVDSNDSIESQLDEEEEGHRGLESSAFAEFEWVDWLDEYRKMKEAKLQSEREEAEAQAAVETGATASADKSADSKEGGTPDKATQASIKASASAARRMGSEAGDASRVAALQKQPADGHRSVSDPLTRQRLQTAEAGDSEQDAIDAQEVEESLAALSLNEDSPGAKAAPARASKPPQLGPARRPDGPSRQGSRPGIDPRRSFSLASAELARRGSGPGSAAASTLASSPGPVKAGFSPVKRLGTDKSKNLSLSPITSRVTPSAQYTSTLGSESASSHVHAHAAGRGRRKHLGGKIEAWWSAVKSGFTAPAGEGWAKAPSTASPRANEGASRTTSVAALSQSLHQSPAATAARRDAPLHTRRDAPRPMPLSASSSTAQPTIAVPSPTLVTQVQSGFGRHVRSQTGNTALSGTESVRTLRPSTSAQNLWKDRGARDEERGTDDVDEAAAADRSDRLSVSPGAEASFVTVQEDTSALEPPQSASSQQSQDTHLTVSSSGRRRHQPKLSLQLEKGLSTFDAEEFDKIGKGKSPSNSDRGSPTKTPLSAKSNESGSSEKEAARMLMPVKADSPAVSPRKSSLQLSQAWNPSTRASPAKAPQELPDRDAAFESDNDGRATARAKAASKAITINSIRQHIRHRLLASKESCDRELRRIIGAINNYVELELERQEDDGRHSFADDNRDVEELEEVFVDDADDADDADEAPGAAAGGGADETPASTSSVSRSASMSRAASNSSSFSAGAAAAAAAITGSAAVTQPDEGHAEGSDANEASTEPHARSPSASLFTSPSLGGLREAAALRSAREYKLPAPPPVSLAGATATSPRTITTPTSNPAKPSNLNPLGRAKSLSRSGARSLSNSRSTSRSHSPMPGVMMTSSVSASSGSPRLSPSRRTRALPAEEAGPKPWMQPLEELVAVAMDVLDVSINSLIVRPGSCSQLIARIQTIGRLWDVHPEWAGRGWFIQILLAVAGLSRVVEWWEAEKGFWNFNDEDEQDAEPIRFILGGQNNEATGEAHDNDTARSSAFWLPSTANSPTRARAFSVAQDKSTSGTDSPASGLLLRDSELDREAAQRFASPGKGLADSAAVHDQSAEDADADGDMTIVDRARQPPQRQTSAEADGEDESRVLTEAISRMQIDERDDDDDDDEVEDVEHHDDADTATPPAPQRFRSAGINVLMELSMDDQRFLYLSPAWKTVLGSDPAELYDTPVEHLLAPGDTDVFAEASRQLEANQSHTVEAVFRLRVEKALVSSSSSAASTDGQSEGSDAVYFQEMEGKGMLMIDRQSGVPSHSMWVFKATGPPEREDRLPEAPLTKGGRALGVVMDEPTAALAHVASISVEPVLCRICERDIPAWFFEKHSEICNETHRLDMEIGECNEGLRELRKAIQDLHNRLENFSTHKADAPPLEYRGVAITTPPASNQPPSALEGLNRSISPRQPAPAAVRKLHLRALDSAIEVLQTACDISTPAIKDEFADEPIEKQRLLSPTSENKVVTVQQWRRPPLDDTALDLLMADVETAMRGKLSAVNRMLNTIVYVETVRQEWEERVEAALSALSEADEASGSSRGSSASASDSGGEDVSEEASDQGGQAAGEAAPTGVQVEQDLATGAAPVASEADAKSTAPAVLETSSKEDAPATTKPNAPQSSPLRGQAVRPPHSRLVSTLSSSAADDEAEARQEDGAEEEDGLLSGSMLLEQDDRDLPAPTSTLFSAMGGATPDEDDIPAVDDKMGGSSHLAPIPIPRSSGGLAPPPATELLAPRSVSGAVAAGPSQRRSVSRPRRSSHLPPPSDGFGGTPPLSPHMYGESLGVSHRHHRKFSVSHKSPMAGSMPLSPRIPPAAPSSRPTASSIKDFDIIKPISKGAFGSVFLAKKRTTGDYYAIKVLKKSDMIAKNQITNVKAERMILMTQNQSPFVVKLFFTFQSAEFLYLVMEYLPGGDCASLCKVLGGLSEEWARQYIAEVVIGLQHLHSKGVVHRDLKPDNLLIDQKGHLKLTDFGLSKIGLLGRQTRQAAVAAASSSAGGAFAGKGQRTDSNSGSLPSSAASFASEARNQALSTPAGTTAGDTAASFSPMTPGLGGMMRNQSFFAAPQRGRIMSSSTDASDSGESDSQRGVPKPLPSARIESPVSLFGTHPLLSDNLRASSGDGGASTPKRFVGTPDYLAPESILGIGMDDFAVDWWALGVILYEFLYGVPPFHAETPEKVFDNILSRRIDWEEDSVEVSDEARDLMEQLMCTDPKRRLGSGGPEEIKSHAFFKGYDWDNVTAEPGPFVPQVTDPESTDYFDLRGASHQDFDDEPSHGPHGAHGTHEFARAIEGKPFVQTGLPPSRMRSRLEKALQTDKEAEHEDFGNFSYKNLPVLKQANDEVIRKMREEQMPALTRALEQSAIYTRHRSFSAKGRPAQRVHSQTLAGPPSPAQSASSQGSTPSRGTAPTSPSAQLAGLAHRRRTSELPPPTAAVLAAAAASTPDGGSQTDRALPSPSAALASGIVDRRRQQLSVSMGERPSLPSQWGAAQAGEGGKKAVPRGFANALGSASAAAATAAASPTAAVSPTQAMSALPATVGGTGHGEEIACLIAEDNPIALRMLETILVKLGCRCVAVRDGAEAVRLAMGESKFGVMFIDVTLPIVGGQDVTRMVKSTRNVNSTTPIVALASFDRGEPVDAAGSLFDAVLAKPLEKMDVCATLSQLGFTPTQGAAAAETGSGQATGEASGVVSGTASAGPDSRPLSRKSTLARKTAGSAARPSTPPATAAAAAAAGAGAGGSGHHTPYSSSPLGSSVLSSRLMEATGKAGRHPLTRRMGEEGGARDQDTAETLSKVAERLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM82</accession>
    <name>W3VM82_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM82"/>
    <dbReference type="HOGENOM" id="CLU_406030_0_0_1"/>
    <dbReference type="OrthoDB" id="2553670at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="677" mass="71929" checksum="86C41493D1397CF7" modified="2014-03-19" version="1">MPAPFCTHSAPDLPHSYAQKHVLICASPEPSFAPSQSRFAVIANGFLLPRFILTLTLIPPFPATAPCPLVAPAPPWLRTISIHKANRPALCFLTHGTAFDEHLKKLFGDLSDAKLDRILQPVARSALPHLSAASSTLRLSLLPIQRLALPYRRIPSASRSSSIALASPARSNLFFLGNRLASHRISHPRPAAAPPASPSAPPHNHSLAADISINPHLGDRQPTISSTLLPPRYPLLGLMPPLLSTGMQASAGVRRTAVWLLAGAACVSALPLRDGPSVFAPSAAQSLQRRAIMKGDNYVPLGNTTVPLSPLLLVFGGLGAAAVALVVALIRILVPSCMSRSSRIVLEERERARQDLRIRGAVSPRGSPGGSPVPGASTPVHPQQRRYPPNKPMRKVGRNSRGSFTPADSASSVSRKRSYRGTSISLSEASKKVDRSVASSLSGFQVPLLNSNDSSSGSSSFHLNAKETMSERAKYPITATNDLNVARNNPRLSFGTRHLARTSSIGKGADLYRTRSGGRQQPEIALHPQPVDPAYAQRWARRESYQHPLQASRRDSTLSAYEVSSSSAEHSYLESTATSRIGSFSNMSGNPLQPLSAPGFGAMPQATQPWASPRSMSRSPTPDSSSPNASRLAVVGAPQVGSRNSSVSALLDSDGSDAGVAPQTAVLIPSRATSFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMB6</accession>
    <name>W3VMB6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMB6"/>
    <dbReference type="HOGENOM" id="CLU_025086_2_0_1"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="272"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="539" mass="59767" checksum="469DBA6DDFC9EC5E" modified="2014-03-19" version="1">MSALARLSGEPTAEAVLAALDAAPNGKIADTRLIAPEVSTTAADAHTDPAKRSEANEAVFKERARWQLALSDVLKSLLSKEMLVMDKLEESTSAPLPEGFVLLQNGSPEIRLVKALPNEAGAGKSIDELKQLLGADTLKNGQSNAFRNKWAKKLPDGTFGRTDATLGKSDAELTDDIQQQLAEILATGTLAAPAADKKLAELRKRKLVATRKLVYFSIAKGAQFSLTVQKLETDLTFEMLQSGSWKTAPFKKYNFDAEGAVPASGALHPLLKVREEFRNIFFEMGFTEMATDRFVESSFWCFDSLFVPQQHPARDVQDTFFIKDPPYAKHIPEDYLKRVTQVHQEGGFGSVGYRYPFDRRVTEKLVLRTHTTAVSSAMLYKLANQPGGFKPAKLFSIDRVFRNEAVDATHLAEFHQVEGVVADYGITLGDLIGFMEVFFKKMGVTNLRFKPAYNPYTEPSLEIFSFHQGLNKWVEVGNSGMFRPEMLRPMGLPEGVNVLGWGLSLERPTMIRYAVKDIRELVGHKVPISSVENAPATRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMC1</accession>
    <name>W3VMC1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Membrane-associated proteins in eicosanoid and glutathione metabolism</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04021</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMC1"/>
    <dbReference type="HOGENOM" id="CLU_134926_0_0_1"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16996" checksum="09D47A5FF4F18A48" modified="2014-03-19" version="1">MPLFVLSPASLAHSALFAGYYSYLSANVIVNRLNTNIYLGSTDSDKVYGPGQKKTNHPADVAKLQRAVRAHANFSESAPFAFFLIFLAELNGAPTSLVHAAYTTLFAARVAHANIGIQAENSAAIGRPIGAIVTLAVTIGAGVYNLNLGWEPLKSFLGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VME1</accession>
    <name>W3VME1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VME1"/>
    <dbReference type="HOGENOM" id="CLU_004969_2_0_1"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="185"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="356"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="789"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="927"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1219" mass="137896" checksum="66A6E280371250CB" modified="2014-03-19" version="1">MPPTSRRSSALPPHSPATSPRKRHPLAEETNLNMKQSRSQAELGPQQQRKRIKRSPSHDAPPSSSPPSASQGAESRTPRQTRSQNGPSSSSPVKRRTMLPEPTPIANGSPSRPRRSATNAPRTSQTNGTRALGTDDELSDGDGDEEEPLNAEQDDAPSAAADSAHAADADHRQHRSPDGFLPGAIRRIALSNFLTYDSVEFHVGPYLNLICGPNGTGKSSIACAIALGLGGAPALLGRASQLGSFVKRGETQGWIEIELQAAPGDTNPIIKRTLTTASNKSDWFLNRRASTKNAVLEAVAEFNIDVANLCSFLPQDKVHEFAKMTDAKRLVETEKAVGGERLVRWQAKLNAHGKQAAEIATKLKERQDEKAHLEQRNQALQVDVQRFEERKQIQERIERLEVMLAMADYNRTKRNVQELQQERDARRQQLAEIAQRGQPVRQKRTELEEKTTKLNLELERLESVYASDDKKRRSLAKTVEELGGEIETKLTEVGMLNRKDEDRTRRLAELRKEIAERSASLGDEPGAQDTAEVEAAMRAARAQQDDCSTRCNDMQRQLQDVRVESQTIDRGMQNYREQLAQLDNVPQQRLEKIRSADEHVYRATMWLRENQHRFRKRVHEPVLLEIALKDQRYAAAVESCIPWVVQKSFVCQTREDYDTFTRELIDTQRLRITVAEVEGIALDSMRADVPREQLAGLGFESYVIDLIDGPEDVLVHLCRQSHLHRMPITLNPNVDVERIERSGKFRRFIAGGENFTINVSRYGADVRQTVSRRIGPARSLVDAVDRERQRTLSTKIQELSDKKKQLEATTRTLLKGDQALKAEKARYDERLDELQRERRDKVGAQKQWQRERALIEARRRELRDKEREPSREEKRARLMKEVRALAQRRAHKAQDLCAQVVQMSKVGDRRHAASLSKWQWDACGVLIDNALRDVHEAEREAAAALEAAQAAHVRARREAADLRAHVQRLIDEAGDLVAGLDPNDDELLDTDRCSAELRAEQSKLDLAEGVRPEVIEQYRARQREIASLSDELEALGELQTQTTARIASIRARWEPLLRRLVGQVSREFSRAFDSMGLAGELRIVEDGDFEKWKLEIMVKFRNAEELAPLSAQHQSGGERTLSTIMYIMSLLQLSRSPFTLVDEINQGMDPTAERVTHNHIVALTCQPHASQYFLITPKLLPDLAVHRRQKVLLVNNGVYAQKRFKLGPILEAKRRAQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMF2</accession>
    <name>W3VMF2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMF2"/>
    <dbReference type="HOGENOM" id="CLU_038299_0_0_1"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="5">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="616" mass="66137" checksum="772BBEFE3F615420" modified="2014-03-19" version="1">MWRSKATVDAELSLSSRKSEDRALAAKKKTLAWRGPPRPIGSVRRLCEKSKGPAERVACFHRAARHHPYHSNTAASDPCSAAHGISIQYEMRSSAVLDLAHTALTLSQRRLVRVKLRKEVPGLGSAGSIVLVQPGRMRNVLLPTHTATYEPLPTPFQLSLNKVSAAAVEAQLETAQVELHRQQTRDALSKELGAIQLLSLRRKLEAVPTVVLSRPTTTKYKPTPVSAAEGSSSADADLPRPPLTIQGSIAGSDIVAFLRENGAFDLETDFSQDAKPVPLNRLTAAQINTACEFQLVNAANSPEADAIDKLGRIKKTGRYTLVAHILASNIRVRIPVVVRPNAASYVASSASAAVASPSITSMASQSRSYATSATRAAPTNMESAMRTKLETEFGPQVEVNIRNDSSKHAHHAAMAAQGGGNGETHFYVHVVSDKFAGMPQIKRHRAVNALLAAEFERGLHALSLRTKTWAEENRTPTQGQQQAENNIGDGSECPQAGSEGSGSLWTAPESSLHPTSPLATGDILSAFYTPPPKRANVSAARATPSQQAKFFRRVTKHDALEPNARQNQLNLLGGVLAGAAATYMVLFADFGQAGATNCFTDLRLLVWGPQGPPKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VML1</accession>
    <name>W3VML1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VML1"/>
    <dbReference type="HOGENOM" id="CLU_696707_0_0_1"/>
    <dbReference type="OrthoDB" id="2554945at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="484" mass="52415" checksum="38FC01EA4BB27F17" modified="2014-03-19" version="1">MESQAPCSFRASPALAAFGCWMSESESVCGWNGRGSQWPLPLSVLRPQLGSSQRRVNSAIRADPARQELLIAYAIFPRVSIHQAPPYDVPQSKMAATRKQKQAQKLQEQQMSKALAEAKPSTKHFTFDDDEELDADASAVASGSTEAVTDVGVQDAPSEEDEEEEGDDEPIEVVSTKASRKQASQESAKQKAQAKVEKAKRQAAEQKRAEKAQKKDAAKAQQAEPAAADGEQNVEPEAVEEEQSHSDEEGAGTSSRLDPSLFAEVFAKPVSAPKSILKKRSAEEAADEVARLQRERKQKRKLQRAGGVVRGNDGLPMKRTQDGTVLRALSSTGSSNHKTTFDDDEDEPEEPLDVIVRPERLDRTTSLPNAKARAFRKRSMAKRSSASKTNASAKNAAGKKAKDEDDPLGLNDPAFLPGGEFYHLVNKGDKAKSTKQDGKAAPAARQAFRGGGVRKDAVAVLRARSRGGPSLGFARSQHDSDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMS5</accession>
    <name>W3VMS5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMS5"/>
    <dbReference type="HOGENOM" id="CLU_017518_2_0_1"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="607" mass="66352" checksum="749A4420CAC9E5DD" modified="2014-03-19" version="1">MSSTPTAQGEAPTAPSATADDDRISLPRLSDGASSQRSGSTGSKQYAEALLANGQEADASESRFVTSRTELWAFYIYYIGNSGLAPFNFAPSQFQNLLYLQATNLGAGMCGNDGQPDCRLRFAGKERTVESIVLLCNGLSFAIQAVLFLVIGSFADYGRNRPYILVASTVVAIAVSFAWLGVTDPEQWQTAIGLYMVGIITYQLCLSYWTAAFPGLARDLPHMRDARARLLNDSNAASPKADADSADDKGETPAAEHAAETEAKAGAHSNDGRMTADKYSLLETMAINRISNIAFAVCSVGELVVLAVIQGMLYGIHADRDTISNTKALSAVVAFGAGVWVLCAIPWFVLEKRRPGQPLPPGTNYVTAAAKQAYLAAKHLRHLRQTLIYLVFYFLFSDALNTSVTVISTIQNQVVSFSTTKLNLLLIVGIAAQAVGIYGFWLIQKRWQLSTLFMFGWVIFFTLLLQGWGFIGIFTQRFGFHHVWEIYCYQAFYGLFVCPWYAYSQTMIAEVTPKSYEFLFFSLFSLVGKTSAFIGPFVTQAIADDTGNASSPFYFLLALSLSSCFLLWPLDIKKSKIEQARFIEHEAKDKHLDAAEIAVAPSAAANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMX4</accession>
    <name>W3VMX4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMX4"/>
    <dbReference type="HOGENOM" id="CLU_527988_0_0_1"/>
    <dbReference type="OrthoDB" id="2547977at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="448" mass="49285" checksum="92F0051F4DB923A6" modified="2014-03-19" version="1">MAEHDLSALDGLLGEIDIEEKGSEDPRAAKIQAFFQRAKAEYTAKIDTPAGFITPPSASFDAATFQVPTPAELLAHRKADLTGSTGQEWTTNYLYVQGHFELCLAYVVSFAVSMDIAFAFGSAEGAREVDTSQMALRRSKQERELSKNWGVIKDVVDVGMRALLTLRRSAPPTQHISCWVPCDSNAGYGWRQVELDTLAQGFLAFSMREVRVGAGDTRAGFSNMVVRTPDGKRGVDMDKVQQQNWTVTHGLALTAGDLALEFGLWRTAIEAHTLFLACRGAMWRVLMALAHELTAYADSLSSTSQRAVEALHVVAKAAVVAALQAVPRRRKVELAQLVVADHRVIPQAWIDAALQPDFTQQTPFDDEDALLFDGLLSTEGERTAVPEEVGVALVKVVFAKKSGLLAMYDKFPEYMREYRQRLHSHGSEWDADDAHDEDGAGLRSVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN00</accession>
    <name>W3VN00_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF605-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02623</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN00"/>
    <dbReference type="HOGENOM" id="CLU_030378_5_0_1"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="494"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="55484" checksum="37B73A694B0242DE" modified="2014-03-19" version="1">MDEALPNPPAQLKALLPFVQRANELRTADKVIAYWCCYYAAQLGISGNPSDKEAKMYLLTLMDTLEDLKSKLADNDAVTNDAASSAYVENFALKVFVGADNQDRAGKATRATAKTFLAASQFIELLKIFGTIEPEMQEKIKYAKWKAADIAKAFKEGRRPTPGPAGGDPKLEAASVEAAMGLEAVTKDEQEYLAREMAKLTTGASDEAVAGAGAGVPDVAHLGKEAPAAPSTTIVPSIAAPPSDMAPPSVPSLSRGSSSGGQNVVDAASVASQGRGSASPDAEEMWKRRSSEQSGGAMSRSSSTHQLDSNRPQLPASTSFVAGQGSSPGSRPLPVPPQRDGLPIPPVSAHHQFGGSPGADQGIGPGAAPPPFWGASAPLSGSPHLSDGDESVLPSVPSDHPPSLSRLDSHPAIERIDPPRSPSHSQLPASPGQGSMLPHEMTGSHLASAPPSAPSFITAPSVHAKAQAPVAPPMAVPIAPAIAPPAFPESLDSRLSTRVQKLAKGAASAVDFEDLETARLQLRQALDILEGRVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN08</accession>
    <name>W3VN08_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN08"/>
    <dbReference type="HOGENOM" id="CLU_015857_2_3_1"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="8">
        <location>
            <begin position="126"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="434" mass="47425" checksum="BD1545DC8BDD2A0E" modified="2014-03-19" version="1">MTPTATSGGAGDDIATFDPFANVRSFKYSGSVKAVYPLSPKPKIPPSIRRPNYAREGVRMWLEFWWQVRIPLLTVALPMFARPRHADALPWSTLFALLLLGLALDALKQFLESRNIKVNTQADQDGVRKSATLAREVLEIAASHIKPGVTTDEIDKVVFAEAIKRDCYPSPLGYHGYPKSVCTSVNEVICHGIPDQRPLEDGDILNIDVTLFHKGYHGDLNATFPVGKKAEEDAESMKLIRVARECLDAAINICGPGVPYGEIGRVIQPLAEAEGCAVVKNYTGHGISNCFHAAPTIYHHATKKSYGVMKPGHIFTIEPMLNLGSEWRDLSWPDDWTVATVDGARSAAAEETLLITETGVEILTAKGQPRHIDTTERRKQLEEQIKARDERKKRRKLDNSGANTPASGAATPTPAPEDANPTTASTSGPTTEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN68</accession>
    <name>W3VN68_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN68"/>
    <dbReference type="HOGENOM" id="CLU_032160_0_0_1"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="598" mass="67089" checksum="9760F53DE1EFFCA8" modified="2014-03-19" version="1">MSDIPLSDAFRRVFRWRTSAAGKMSSYSRHATGHLFVPGPSTKPLPIWAAVVPPLTYYLALLLLPPLSSKTFSRPIRRAASAVRTVLALVSIYTFAALPFKYFYPGSAILTYQLGLVGLYGASRVLDIFFLSYPRIPRRIFISPAGKRPDGKGANIVHPYTSARNETWKTEPLPKKLVSFDRAWWALDLMISMRGIGWDFASADVRHDSHPWQPPSSAQLRRAFFKLLPILVGCIWTIHNLHPKHLSTLNPTILDLDPARRVLFVAATGISLYTLFDFGYTLTSAFALPILHDAVVPAVTSKAASKGNRKTIKGDRLKQLRGAKGGGDDSETETETEDESPLALEARQMQHQQLTLRNIDFFPLLNPAGYTQATTVRRFWSYAWHRLFGRPFGVYGTLPFTYVAYLMEDLWEGKLNDPKRKQARREIWPAYHPDPMRALERGRADWAKVLGAFTASGFIHAVSERAALGGRIAVPVTNIWLERAHARGMGHELRAHPSLAALGIFKWSPLQFVPPISGAGEFSFFFLNGVAVVVEGAVARYVEKTRKRSSVDDKYFSMWYDRPISIVWTLTVLLFTGQAFVEGWIRSGISREIALVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN90</accession>
    <name>W3VN90_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DFDF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN90"/>
    <dbReference type="HOGENOM" id="CLU_380405_0_0_1"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="3">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="702" mass="74607" checksum="C9E01B7B7867F206" modified="2014-03-19" version="1">MSSPFIGLNVKLTLHSQPHLHLYAKILSIDQAANTLTVQKLDGSHAVLERTDIASLAAAKPVETTSEKAATSAAAKRKSNQDAAASTPSDQPHLLAPKTADPVGSRTSTPSRSPRPQNAAAGAQTPRSAKKKAAALASVSRGSSPAIPNASLSDEFDFSAGLKAFDKKKIWDDIRASDHTDPASLLVSHNRIANAPVELVRGPNGVGPANSVSTPDRGRSNKKDGQQKLRPNEMVLSPSPERVPSPTPASPAAPVAASVPVSAAPSEPAGKPSYEELEQKIRKLEAELALARRRNALLEELAGLGLGVSARTDASADYSASPAAPTAPPASQPAQASPQVRSESRNRRSDQGVTETTRDLSNMTLQASAAPTGQEPRSSTPAALSSALAAAGFAISGQSTQSSSAGSTPAPASQPAEVAAEKEEAVFGHIVEAPVLTLFFPTAALQHAALARIEAFYESDTNGKRYLTLQEAADERICRNYQGFNFPLRQGVQDWLDAMHDAVGSDTEAEAQWWRPHCSAEEVQLLELLVSLRAISAYEGSSARSDDGEAAVSYVISCVASQAHSTLPHERLHALYFLSASYRALVAQLYDSLSAPAKKVIEADLALRKYAPAVWRDEFQAYLAEGPATEKEFGNKPASECKLIAQQLRAQLARLWTELGARADETAMHDAWENVKWHTLDRYAAAQKKKPATAKGKKKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNH9</accession>
    <name>W3VNH9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNH9"/>
    <dbReference type="HOGENOM" id="CLU_2172128_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833390" evidence="1">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="110" mass="12087" checksum="BBAB16896C916EA6" modified="2014-03-19" version="1">MFLKRVLVGLGVLEGLAAAVDLDPTPMIVNNAQYELHCGAGSDPNYPCFTFIGGDLRDVRAEMYIEGDAVGDNAPTTDFLVKDDQMQDFTTTDPNKSFSIYWVDFDVSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNJ4</accession>
    <name>W3VNJ4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNJ4"/>
    <dbReference type="HOGENOM" id="CLU_2334537_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="98" mass="10338" checksum="219F2D249DFF2BFA" modified="2014-03-19" version="1">MAAFDTQLRLVGKSHYSEINSVVTGKDRIVAWLLLLLHALALVISVLLLLSPNKLFNKHSGLATVSLNSTLLVSPLSNGWQAADSPSSSTNLTAPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP37</accession>
    <name>W3VP37_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP37"/>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="59740" checksum="ACCE6BFDFC6360D4" modified="2014-03-19" version="1">MSSRKDSISSMAPESAKTPSEKGIQAYAVTDLDLDNNPSKLTKIEEVIEAEGHLSDAEARKLLRKIDWHTVPCLMAIYGLQYADKVSLANGVLFGLKSDTHLKGQEYSWLTTIYYLGYFLFQPLMNYAMQRVDAAYVLSAMTVVWGIVLVTLGLCNNFAQLMAVRFILGALEGIVTPGFTLIVASWYRKSEQNARQLLYFAMNTGFSIWVSVVIYFIAKKAHDDGTVSGWRVINFFLGGLTVFTGCVTAIFLRLPKNAWWLSEKERTLAHARIIDNGTGTGETQAWKWDQVKDAFTDPTTYFIFFINVTCCIPNGGITTFQSLIYQSFGFTPLETILYQLPSFAMSFCWILFAAFMIHKFPRLRFFFMCFTVIPAFVAVLTAGTLPNEPRYRWTRYGVYLMSVLYALQSFLMWALMPAIIGGRTKKTVVATICFMGYCVGNMIGPQVFRASDAPRYIRGLIVVASMLALVFVLCLCWLMYLIAENRRRRKRLAEMGVSEEERLLKNKINGELDMTDNKNIYFLYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPE5</accession>
    <name>W3VPE5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPE5"/>
    <dbReference type="HOGENOM" id="CLU_742262_0_0_1"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="427" mass="45482" checksum="2BEA4BBA9A0EB7F8" modified="2014-03-19" version="1">MAVRVSDRWLEPFGDIFFHLADWNPNRKHHRGRIGVPPPSGLSRAAGPFLEKSARLPSHDLPATIMPNLDSLLSFPTPGAGSSSGSTRTPIPPRSSHILVTDTTDAPALFVLMHFLRASHAHNKTLRLGTDAANSKGKAKARTKLIWLGCTSEGIVHLKNVARKSGVHLDEETAQGTFKFIDAAAEVYDAPGIESSAAALSLQGDTSRAHKGFKRIYDQVARELSSASDGDNQLSQSGWASRNIIVVDDLTALAWGADSIDTQEYPANVGQKTSQWLGALTALATKNDASVVTLMHADATSCSKHGASDPVDECLLSSLLQTADVWVEVKELASGRARDCHGEITVHPLVRPSLAQTLASSASHAEQHRDVPPLQAFAVETPCPTRAKAVLYRIAPDGQSAALGGATTGSNTGRVQVWPRGTGRGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPV1</accession>
    <name>W3VPV1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPV1"/>
    <dbReference type="HOGENOM" id="CLU_1696270_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="155" mass="16533" checksum="BC9551034E265D66" modified="2014-03-19" version="1">MSCGLLRLALQRLKQQKSTCQAKRAWLGGSSSIRSAPLAGLGNASMPSVGGILALSSGTPFDIRSPTGGLIECGGTFGRRSISPLLRHCCQTVATEAIPILPALHCQVTAGARAFGSLRQLPLRLPHVSEDLSEEQQPPDEDELSESRTMQVDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPW4</accession>
    <name>W3VPW4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPW4"/>
    <dbReference type="HOGENOM" id="CLU_045003_1_2_1"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150128" description="Peptide hydrolase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="134"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="427" mass="47345" checksum="B43E1150E089B734" modified="2014-03-19" version="1">MSSLQALRLAASLVVVLCALVPSCWGHAVRSQTRDYGRFSPSSVKSIAALSDPARLIDVRDPKSLLSRILIPRPADTDNSRKVREAILDVFRHDLGSSASASTMDWAHPGKLGWHIEQHSFLTDTPEGRKNMTNLILTKNPAAPRKLVVAAHYDSKYFSAASGMAEFVGATDSAAPCAMMVDLAVALDDALDARERRLHTQEQAMPTIAQETTLQLVFFDGEEAYRTWTHTDSIYGSRALASHWTSTFWDATQFDRSRSAEHRLEARRARGAYGPIEHINTIEHMVLLDLLGTANPTVPSYFDSTKWMHQAMADAEARLRDSGVLWPAGHSGARSFFSHHKPWGGIEDDHLPFLHAGVPILHIIPSPFPSVWHKISDDAGALDYATMHAWCMILRLAVAEYLDLDIPPQGKAKREYKAELVSPRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPW6</accession>
    <name>W3VPW6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Antiviral helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01903</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_1_4_1"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001047">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="335"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="618"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="541"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1295" mass="142545" checksum="DBD5E8BF5375A20B" modified="2014-03-19" version="1">MAARANGALDAIDAHNRTVAAMRSSSGQMSSLPASDVEDTVEALVDDFLLPSKSLSATELTRAQVHWSRKPKLDHMLWAEPSTSLHSLEFVRAGLDGRIVSYREVSHTSAPLLDSKSSASMARKPAASSNFVRGKSAYVPFAPGGLENEVMKTDDTDPDGEGLSEAMRSQIADMEETLRSGRGLRSKAPGLSRTFIDPTMETPQDDDDLDAGASASAKVQDASQALDVGLGLAPIPVYRPIEQQRPGASSRRAQVDGDAVGASSGNAQDAELDELLPVERPQPLAHVRRSAKIEAKRDWAHVVDVNQQLTNFHELVPQMAHAFPFELDTFQKEAVYHLEQGDSVFVAAHTSAGKTVVAEYAIALAQKHMTRCIYTSPIKALSNQKYRDFKQTFGAANVGILTGDVQINPEAPCLIMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDQERGVVWEEVIILCPQHINLILLSATVPNTKEFADWVGRTKKKDIYVISTPKRPVPLEHFLYAGKEMFKVVDARAQFLGTGIKDAGEALKRKQEKDREAIAAAGGGAARGGRGGGAAGSNSRGNRGGMTPARGAAGRGRGGAGGGRGGFPSTTTVRTGLDKNLWIHLVGQLRKKDLLPCVVFVFSKKRCEEYATSMPNTDLNTAKDRSEVHIVIEKSLTRLKGSDKELPQIKRMRDLLGRGIGVHHGGLLPIVKEIVELLFQRGLVKVLFATETFAMGVNMPARSVVFSSIRKHDGHGFRELLPGEYTQMSGRAGRRGLDPTGVVIINAADQLPETAVLHKMLLGQPTKLQSQFRLTYNMILNLLRVEALKVEEMIKRSFSENAAQKMLPDQQRKAQELERQLSRLPHPQPDELDAQLATYYDLCAAVLATYYDLCAAVVASNQSLFELALGHQQGAKNFAAGRVVMLRDAHFDFDVAAVVRQVSAKEFLVLAAVTAERKRGDLDQLVSDAGVPPLWPPRVEPIEAELVYDLREVPLSSIALVTDQMVKLDVPLITAHRISAMNRALEALVAVRSDFCSAEAIREAEWSKLRRLDFQEAVRARDSYALKTQQHTSLRSDASFTKQYAMVARYKEVTLELERLLRLQSDENLELLPDYHQRVNVLKTLRYIDPVTESVLLKGRVACEVNSANELVLTELILENVLVEYEPEELVALLSIFVAQEKTDDIPELPPRLAQGYEQIIGVAERVSAVQLSNSLASEDFTLPSKIALVNVVYEWAKGTDFATIAAMTDIQEGSIVRVITRLDETCREIRDAARVIGDRDLGDKIQAAQARIRRDIVFAASLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPX3</accession>
    <name>W3VPX3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPX3"/>
    <dbReference type="HOGENOM" id="CLU_122500_0_0_1"/>
    <dbReference type="OrthoDB" id="2556513at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="7">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="191" mass="20911" checksum="93E794059B357FC9" modified="2014-03-19" version="1">MADAAGQCAGVGWSRLASRPGKESAAARKRGPWTASIRCPSKLPNPDFFTTNQHPSTIMSDINNITNAAATEGSDEYHQPTSVDKGKGKARAVEPDHDEEEDDDDDDNEDDEEEDEDFNIDDDELAELIEDEEELAEIDPSNIVYTGRRRNAPLDYTSEEALKQAGLDSGAGAAEPDEEDAEFKSEEMTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPZ2</accession>
    <name>W3VPZ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RPAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPZ2"/>
    <dbReference type="HOGENOM" id="CLU_023272_0_0_1"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="6">
        <location>
            <begin position="295"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="405" mass="43081" checksum="02CAEC73F92A6A97" modified="2014-03-19" version="1">MGRSTDKAKALAEKQKGNDAFAKKQWAEAIGFYSAARLADASEPTIPLNRAMAYLKLSKFLDAERDCTTALELSPNNVKALYRRATARMGADKFEAAREDYNSVLRLDAGNAEAKAGLAKANEALERAKKRRTEPIDLPTVAPEGSSANSAAHANGFDLGPANGGTAQIDSNSSVEAARKFLQQVGMSDDPEEQDSGSKLASSAGNVPSKFPGETGGLLREVTTRRTPNPATAKQDTQRASSSATTVAAPTSSSGSVSQKTASALSFGAGPSQRPARVTQPQTLSASTSNPGKLSAIEFQRRWKNKSERLQLLSSLDIDSIPGMIDAMLEPELVAEVLETLAQGHRSSPQDGELQRTAADVLTVLPRCKRFGMTVAMLDESEKAHAAYLVDAVGRSDLKSVWELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPZ3</accession>
    <name>W3VPZ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_01857</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPZ3"/>
    <dbReference type="HOGENOM" id="CLU_033172_1_0_1"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="112"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS63560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="425" mass="45991" checksum="6E5708A2C21987FA" modified="2014-03-19" version="1">MSLLRQTASSQLGRPLAGLAAASARQCAQPMLRSTPAPASRRGRATAVDPADPAAHGIASSSASALGATPVAKEGDIRHNWSRSEVQKIYDSPLLELVFRSANVHRMHHPVNRVQLCTLMNIKEGGCSEDCGYCSQSSKYETPSGASKLEDLETVLTEARKAKANGSTRFCMGAAWREVGGRKRGFNRILDMVREIRGMGMEVCTTLGMLSPEQAKQLKEAGLTAYNHNLDTSREYYGKVVTTRSYDDRIGTIANVREAGISVCSGGILGLGEEHEDRVGLIWEMGTLPEHPESFPVNALVAIPGTPMENNKPISFQDMLRTVATARIVLPGSIIRLAAGRHLFTESEQAMAFLAGANAIFTGERMLTTPTSSWDDDKSMLARWGLRGMESFEDKTMAPHKPAVEAAAVEERRAKAQASQAFQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPZ6</accession>
    <name>W3VPZ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPZ6"/>
    <dbReference type="HOGENOM" id="CLU_028286_1_0_1"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="203"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="452" mass="50319" checksum="D48457120CE87A4B" modified="2014-03-19" version="1">MPARIPFFEASESLQQRWRESTASPRVTAQIYVFALLIAIGLFRRYLSPRSSPDHMYGSAAATDEPGAKDETIAEVAEIFIYPIKSCAGSSVSHAQLTQQGFDLDRRWMVVRLREGKVEKISLREEPRLTLIQPSIDETHNRLIIKLTKEGERAHKGTKLGETETVLRPTAEELGKWKEVPKVEMYGDFADGRVAALPESSGRKLSPSEWVSEFLGYAVLLIHFDTTSRTARAAFPIFKPPTDSASWSSHDRGELYRERGIEFQDEYPLLIATQESLSLVRNQLTSALNSDTSQGRPIAGIDAAKWADSSALSIARFRPNIVLRSSPGGAFAPFSEDSWERIWILPNEPSRSKAVLQLVARCQRCLLTAVDPITAEKDPSVPLKLLNRSRMRVKKTASEGGNGRAGPCFGMYAIPLPLDTSAYGELSTGDSVKVRWRPYSTDDEPDRSHLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ19</accession>
    <name>W3VQ19_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227556_0_0_1"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd06629">
        <property type="entry name" value="STKc_Bck1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
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        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="Znf_LIM"/>
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        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
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        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
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        <property type="entry name" value="LIM"/>
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        <property type="entry name" value="Pkinase"/>
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        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="S_TKc"/>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM_DOMAIN_1"/>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="622"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="2369"/>
            <end position="2639"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50023"/>
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            <dbReference type="EMBL" id="ETS62881.1"/>
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            <dbReference type="Proteomes" id="UP000019462"/>
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    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="2658" mass="285581" checksum="C6DF6D31EB116419" modified="2014-03-19" version="1">MSAASGNMAGFGARKFAQDMYQQSSVQSYPTAHYDHTNQYYPDSSQWAQPAPAPTVDHRHYNSNGASSHSSNASYGGRSAQTTRTYRRDEYSQQQYTTSATTSAKPAPPPAARTRAPVARAPARSDTLQSSATDSTVGLAYAQSNDSAYGQQIAYESNDSRYRSNDSLFPPSHRSPATHHPPGRTADRTTVYDDNYEEPVYSNTVDEMFRASSPASATRGDESIDVSFTIVRATVFEPVLPKAKCADCGDSLDFEELANHTCQPASASKLPLLTIQVPPSSSSSAVSSTATSPAIATPRSPFFDRYDHLISQSGPASPALLGCASPTVEVKQRDDETPTAHAVKILGTHAAVKVSSIQTSQAVHLKADRSPPVQPPQMQRSASDTDADAVAAARRRMIEQQRAAKKKDIMANTMPRAATTPSLYKPEAAVAQAAGAAARSMSTRVGAANGGTSRLSASEAQHAKKESSSSISSTATDSSGRQRAYVGKASSTANITPSSSYERIESHSTPTKPMRDRAPVDLSSIEEMMKGLTASPEPLQRMLGDAGRSERERALELELERLRDKERTRQLQALRLREKKRKERAAKRCCVCDCSLSSSRTPFVERDGKLLCARDWKELYLPKCRKCNLSVEKGAVKSSDGALRGVFHRACFACAACEAPFADGSFYVFNNQPYCGRHYHRLNGSLCRECEAGIEGDCRQTDTGDRFHPHCFSCQYASKNGACSQPLAEYYMVGGQRLCERHADKVGQRLAKAGQRQHDLRAHKRMTMLHSLRGQQSGSSSVAATAPAPAHTRHKESLALAEALQLLRAKQLHPSYVSSSSRTPLPLLIAPDPLISSSVLVLLPPPPQRLHTCMLPHHLRSPLSRPSPASNDAKSRFRTPPPDLVRVAQSSRQARARAAPPNELTMSYHPDSFVTSPTSAADDPAWQLHSSTDSYLNWDANPKSPLSHPHDATLSSTPATAPPMSRLRSSSSTATPSVASSRTPNDPGSADTASLLSHHGHSNNSPERPQSPSYFAKLYFQPPHRSSSGTSPTITFTGAPAEPSLVAASQLPALSFEGNQSTAHLSDPARQQAPARRSSVSAASNSPTSGTPLSPTMSSKSAASAGGFFASLRPSSPGNLAAATSRIPEGETYVKPRRPSSVFEHVGNVWERFGRKVHHTRSSTSEQQSSSSSHQRRTASQTSPTIGLTPEAADPFDNAHHSPSGSIASQASPSHSTATESECRTPATPSAETPASLSTPQPLPSAPAYSQLSSADTAADTRLQDEVEELPYLAPEPAPTFAQPAPAAHNSPRTSSANRSQASYRRESSLFERVLIQVTDDNERFAVVDISGVDSADAIKERMFAKLHLFDADHSSFQLFRTEIGQSEATGPVVNDDALLVLCLQMGDDRGTLKFLVQQTAPPNATVRAMPPPTSAAGQQRALNEVRRVSGTGSATSNHLRTDSQSSRSSISDALIYPEMVGADGAHEGSNRNSGSSLTRSKAQARRALPSAPPIDDLRSPTGYHDRRSIASSGEGHAQEASSKHASSVSEGSGAPVMLSQRSSSMNATQPAATASSNNARRPSHVEDERPRFDADASASASANRSLQAPANGLGHRQERSDEGVRHQSRQQAPGLTLHNAKSMDDLHRPAHGSTHAPAMIPQAEVRAQAGLDRDGRYPAPSIMRPSTAAPAGPGARDGGHGHRQYSSDALGTSQGPVDPASLDPRMLQRNRSAQAAIPSSQQLANHGPTRMASTPQIRSPPMQPNYPARGPVDSRYARPAGMEDPRYAGMPTHPAQSLQPRPTSPAARPPQFNAPSTYGGPNSYSVQSFGQAQRPLAPGYVNEFGARAPNAAPNFNTFHGHDPRLGANGMQGSLTPRPYSYHEASSTHHPSYRPFSPQLAPSPYRTREDPFTTRYFPASSSRQVSEFQMQAGRLEPGMTVQQTLRTHEVMRNQAVSGPQGQAYLGHAHPPGPSYGPRDPRQPGQPSQYMGMQPYPNASAPPSMPSMPQRSSHPSSAHPNPHHAPSSRPQQFAQQGPSQHAPPQHSHPPARNAHDMVNSNASAGSSGGDGDTVRAEPSTPGPSRPHTKDGLGSASPSLDPPRAPSPSMAPEENGTVASFGVFDDDESESGTWAQPLDSDVNAPRLPLRLDGEEDAASDDHGTLLPGQGALLQSPARVGGSSPKRPELRLTIDPAAGPTLLAPASQPAGLSPVPSSSHLSSSLSSGGITRSNSFARRDDDWAFRPPPEQLYENLDDFFPKHDLDKPLLDTTAVPESPMVSSPRSEAAAAGSMASSPPTAPQQAMSHRSRLKRSIRLVAQDRKRFLDRAGKRATEKDAEASSGLVRRRSTKLWGTRVVEMTPGQELATPASATSAESPLSDTSPPKPVFKWVKGDLIGKGTYGRVYLALNATTGEMIAMIAVKQVELPRTASDREDSRQKGVVAALKSEIETLKDLDHPHIVSYLGFEETTTFLSIFLEYVPGGSVGSCLRKHGKFEEPTIKSFLHQILDGLAYLHSKGILHRDLKADNILVDFEGICKISDFGTVRRSDDIYGNVENMSLQGSIFWMAPEVVSLSKKGYSAKIDIWSLGCVVLEMFAGRRPWSDDEAVQAMFKIGAERKAPPIPADVKLSKQAAHFLKNCFEVDPAKRPTAQRLLDHVFSVPDESWHFQQSALWRSLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQC3</accession>
    <name>W3VQC3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQC3"/>
    <dbReference type="HOGENOM" id="CLU_2400622_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="93" mass="9766" checksum="2CC4F00E2F4F0D49" modified="2014-03-19" version="1">MRPLLRESGHLPSPPVAACEHAPPASASSWAGASVSQCAKSESILETQAIHSPRSYHQPGFFVLHSTPPSSSPPESTIILIQSSRTSAPHAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQV5</accession>
    <name>W3VQV5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQV5"/>
    <dbReference type="HOGENOM" id="CLU_014743_2_1_1"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="402"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="872" mass="95952" checksum="F6AE8BE45EABC70B" modified="2014-03-19" version="1">MVLKKRSFSESTLEGRERSELRLCFAVDWALGPPGESGGVAVEIQKRISLPPLFELASIFRLLLLSLTRPPLNSLQGVLPWWMVRPALPPSRTQPFQRMSDDIEKQPFGPDKLVLPPSSDPSASAITTTTVPHTPSWSQVFLYRMKVAASLAVLFGLVQLATSSPARYPISPRKNAAVEGYGQQTSAYTAPSAFPTSIFASYYNAPESMTAEPRPVVTDVARTSVFPDILANPTVLPPGPSPSEAVYPVPTGAATPDVADQVRTELTNTFSSSAANCTKCTDALKTAQKLAQQAPEQVPGMLVELCKKYNYKSAATCEATYAPQVLGSVYAQVLSYANFSEGSTDAQYICNIVVGSSTSSCTLPAPREIDEGFLDDWFRGQRIPPAEYNRNVGEPTKNGNDLRVLHMSDIHVDPRFFVGGEAACTNGRCCRADAYNATLSSGKFTQGMLPKANISEVSTYWGNFKCDTPWSLVMASLEAVTPLNGGEEVDMTIHTGDMVVHDLAQYVSQDLVKYTHQSLYDSIRKMLGKGPVFNAIGNHDSAPSDFASQGALPDGRSDQLSWDWDNLARLWESEGWFNHKEAEQARKHYAGYSVTPRKGLRIVAINTDFWYKNNVFNMIHTHDPDYSGSLRFLTDELLRAEKRNERVWIVGHVLTGWDGSNPLDNPTNLFYQIVDRFAPHVIAHIFFGHTHEDQFNLFYANNATSVAADKAKAVSFMAPSVTPGNNVNPALRIMHVNATTYEVMDYHQFYTQVPTFPQLPSSQHGPVFEYLYSARDAYGNFTASNANSSHPTPGGVWPANAPLNATFWAKLTEEMHARPELVQQFTVFQGRNSPKSPKCTDDKCVQAKICYMQSGSAPLGKKCTQGYGSVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQZ9</accession>
    <name>W3VQZ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQZ9"/>
    <dbReference type="HOGENOM" id="CLU_175758_0_0_1"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="1">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="98" mass="10522" checksum="AA28E9A3157D19BC" modified="2014-03-19" version="1">MAKPQAEVIQEWADFDSSGYSFERGRMEKTVQSLCFGDQAAVMPAHLAAGPAQGQKLKKEDVEFIVSELLVSRGIAEAALAKHKGDMEKALAELVGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR74</accession>
    <name>W3VR74_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR74"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="104"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="610"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="727" mass="79492" checksum="54A765A9F0209181" modified="2014-03-19" version="1">MPATISGLDVAFPQDQNLHTFLFSNPLQNHPNRFADEYPNHTYDGAPIPQQRPVLVHDGTGAQLSWARLKADSLRLARSLQALTGPPPAFAPNPKRPLEPIHAPRTTVLMHIPNGMVWPLVALGTVAANLTVCPISTYLSPRELAYILAKARPQLLFTTVGAEGEIPLRKALQLLLDSPPSDLGQVMAAEIRAWATELARDWDQAKAARLEKSNQIPFRRRRVWTVDISSGMDYYGTNFDRNGVASAHDPRDWTHLLLPPPGSKAEGSIASLDRPAFTPAPMTPEEQQRRIAFVLWSSGTTGQSKGVLISHRALVSNTLGIWDSNPHFSGPSRGSNGGGERWITLAPWYHVYGLATVLLPTVAFGTTLIIPASPKFDLGYYLRLVTRYRATFSHIAPAVAVALRSCPHLDPTSPQSKGIDLSSIAAFLTGGAPVPVEVVRKVYERTGKYIHLGFGTTETCSTAQTAGLGLDADARGPRDELGSVGMPVPNTEIQIRPLPGTSQEQVEQRRDEIRSMSRQARARGERAPLDPELVGEVLIRAPAVMSGYFSGLSSETHSALDPELTQGAFTEDGWYRSGDEGCLDANGRLWITGRTKELIKVKGFQVPPAELDDLFATHPELVDAAATGYVKDKSTGEEHVLLLVVPKDKSMLTNEREMHELASRLHTWVGDKTAYYKWPSTYLFADSAPRNPTGKLLRKDIAATKGHKVDIARQSRKAASPNLQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRA8</accession>
    <name>W3VRA8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000310_0_1_1"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="656"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1429"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1487" mass="163063" checksum="DA96FAE8CBCD835C" modified="2014-03-19" version="1">MLPQTPPAAFARPSQVILGSVARHEAPSPSAAQKLERTTSLPRDHIAILEGRQARDSLTAQASFDQVCILSRDQRFDQALPFWDAFSGSQDFDRCISCIAIGLSVDQDHILLAAAMDHRIAVWYAPATASSSSRRWKVHSTLTVQEGVVTTLDIVNGQLLSGSTTSLVLWRLDTSDIPIWRRFWTRSVPAPIALARFSPDATSIAAIAKGGQNILIWQHQPRSTRPPVLQQRLYHARSVSTFVWRQPPESNSQTDVLISYASDGVARIWAPVIDEPTQLRLWCSVEGPTNAAAANHAPSPDSQNGFETFYLDPYILSAALRLNLSILQREMQMVDLGLGSSAQLDAHKAEIDMDLKRTRIHRLEQLANETPDMLVSFDADGFMTLTAVANIDRRPPTLLQAFTVLRIPSALPSNLGTVCMAKLLPLHVTPDSASDAPMLTLHLQFKGGQSLTYAINPATFFDGRGSGITLDTCHPCAPPALPNASPTQRRTHASRIERLTRSADGNHLISSSRAESISWSLDASTSQLQFNGTVQDAVKSASSSDASLTAYLFANGSGTLRRATDGAKVQFACEPDVQSLVLASLDGDDILIATSDTGVVLSWKIESSHYLRLGPKHESRLFGEDAPSRRLAVVQSAADSSSQQTNLALVSSDTSGLVEVRTAQADTTTKLRWVVKASFSQASLPPKFISCSSEGLIALLYCDDQEVQTLVILNPKTASFNSGQEHRHCFESAERIIALDWSPSTRSTGALAVVFEHHVRVLCPGRISMFDELDEGMRTSWQELVRLDLRSCTPSSIRAACWLNSEQLVVASGSVLYVNGPWINSSMQETAKQETKHLAELLAEVGGPVVQYHPAFLLQCAQWGKMSVAKAIIGNLEKATLGCNKDEVAGTWDYEEVPIHQVLQNDASGAGSKAAVSDNRRDRRSNVFDDDLNFDAQADEDPFAIARIENLAQLLQDVHPPHLTPADLGTLVSIVKTIGETVREHRTLDASGIRYFIALRHMTNGRASTKPDSTASSAGLGYRDFSWALHSENQETLLACVEQAYGNKLDWSAARATGIFAWLKNPQLVRSQAEAVARAQFMSSEDRDPVKCSLLYYALGKHKVVQGLWRQAVWHPEQKKMLTFLAKDFDEERWRTAAQKNAFALLSQRRYEFAASFFMLGDSLRDAVNVCVRNMDDLALAIALARIKEGGDEGPVFRELLQTRVLPLAFERGDRWMGSWAFWMLKRRDLAVRIIVTPLRDLLADPGVASLVKAGTACGDDNHNDPALALLFSQLRSKSLQTIKGLYDIPEKKVFDFVLTTNTALCRMGCHSLGLSLLRNWQFEPPSVTSASTLFHRVSKHDLHTLSRVDEAMLESPDAAPRQAEHSTLHRRTSQTTMSPPSSPRMARRRSSLLQRRSSIINDLDIASVQSSQTDTAGKLANGLGVVNGDKPLSEEPADANAVRESTSDAAATKDKPKKQGISIFKSAAASNSQQGAQEFDFGSFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRB8</accession>
    <name>W3VRB8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRB8"/>
    <dbReference type="HOGENOM" id="CLU_034597_0_0_1"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="62"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="320" mass="36121" checksum="A1268D467DA5A524" modified="2014-03-19" version="1">MAFADPVIAWLQPYADAYGMHHAPAHFPTLVRSALLWFAIQTLSSQLSPRLLPKTFAKFNRKTRISWDIHVVSFVHAALITPLAARIWWKARQTNALGMHTHPLAVDRLYGYDYEAAQVYAIAQGYFVWDSVVSILHEGPGFIAHGLVALIAFTLVYHPIFMYDGMGFLLWELSTPFLNIHWFCDKLGKTGSTVQLVNAVFLLSTYVGARLTFGVYNSLSFFKFVVAPAKPHHPPIPLHLKTFYMVGNVILNSLNFFWFRAMVRAVQKRFTVKPTPDSKNGKLDAQKVVRGQQGIKLGVQDKDDEQFWQEAGAKKAGKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRL9</accession>
    <name>W3VRL9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRL9"/>
    <dbReference type="HOGENOM" id="CLU_039854_1_0_1"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="108"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="430" mass="47264" checksum="1DB6BE8B8B75A6CF" modified="2014-03-19" version="1">MSGNGLPTVLAVGTGEYTTGFVGNSQSPSDKKLGVVGLVMFDLRRRGLIAPEIKMVGTNGDKFAGIRDHFKRNIEHKYRDLSTAFTSYPEAGVRDADAYKAAIDSLAPGDAITIFTPDSTHFDIAMYAIQRKIHVLVTKPATQTLEHHQKLVEAAERQGVLCMVEHHKRFDPAYADARERARATLGDMNYFYSYMSQPKNQLETFKAWAGRDSDISYYLNSHHIDVCLWMTAGRALPLRVTASASQGIATSVGCVAGTEDTITLLVDFAIIDSDGKAQQGKVATAVFTASWSAPQGAGVHSEQHFHYVASNGETRINQARRGYQFTQEDPAQAVTGGSCTDFNPFYMRYTPDAEGYFAGQHGYGYLSLENFVTACTRINRNERPASHYDTVLPTIRDTVLTTAILEAGRRSLDTKSTVNIVLNDGKFSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS17</accession>
    <name>W3VS17_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS17"/>
    <dbReference type="HOGENOM" id="CLU_780733_0_0_1"/>
    <dbReference type="OrthoDB" id="2556779at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="425" mass="45496" checksum="1D8D45CB6E991EE6" modified="2014-03-19" version="1">MVRLDTPDLLSQMSSLSQPESSQQGNAGTSQYDEQQTLSGAINYAAWQPNGQVSTSTRWAEVSTSTSMNAVEDSFASFQPSIRVQNMSYPANGPFQPHLAGDLSSQTSSGSIMNDALSRESISDASTRRESQGSQATQKKRQNMLRIPGAPPTVQSAPVRNGVDVSAIAGSTAAAHGAGGRPSQGSSLKNIEAAIQSFWLVSENRMQQMHEELRSVSMLVKTACYEQEQTRLNVGQILALQVQITEKIVRAADERKYIFARIKTLEETMATQHAQVQEELVLIRKELKEGLDSVVEQTQRGRKPPAAKSAGNGAAAKNGKAGSPTSKKAATSAANAKKRKQSSAEGIENVCTPSADVGQPSTLRPSPPQRPGSAFAFPDSLPSFQVQDASFARMQPQTQPYTKSAPPYVQTHQQSGGSIEIGLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS58</accession>
    <name>W3VS58_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_01926</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS58"/>
    <dbReference type="HOGENOM" id="CLU_177920_1_0_1"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS63627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="79" mass="9029" checksum="1BD0E4D188190780" modified="2014-03-19" version="1">MENPHEERQSLLLERITKSVHRLNEALQELDRSVVEINNHNQAVIIVSDLSEAYRRNAAFNLYNMDAHAEDVQGKSSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSD5</accession>
    <name>W3VSD5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="11" type="ORF">PaG_01008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSD5"/>
    <dbReference type="HOGENOM" id="CLU_026481_1_0_1"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="9">
        <location>
            <begin position="54"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="10">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="397" mass="44077" checksum="50B440CF9ED0D4F9" modified="2014-03-19" version="1">MAPKLCVICNKERAVLRRPKTAQQICKECFFYVFETEVHHTIVSNNLFQRGDRVAIGASGGKDSTVLAHCMKVLNERYDYGLDLFLLSIDEGITGYRDDSLETVKRNQQQYQLPLKVLGYGELYGWTMDDIVKSVGRKNNCTFCGVFRRQALDRGAAALGVDHIVTGHNADDVAETVLMNVLRGDIARLERCTEIVTKGPDGSEDPEHDGCGASGSNGIGVGGSGIRRSKPFMYAYEKEIVMYAYFKKLDYFSTECIYSPNAYRGYARTFLKDLEAIRPSTIVDIIQSGQNLKISSVVKQSRKTELQNCVRCGYISSNTVCKACILLEGLEKGTPQLGIGSEKSRKIKDIRTDNAAKAQEEAGGERRIPQWTGVARNAPPISTLPFVPPQRKPDLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSF7</accession>
    <name>W3VSF7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSF7"/>
    <dbReference type="HOGENOM" id="CLU_154777_1_0_1"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="128" mass="14938" checksum="AA8CA84BA0B4C1DD" modified="2014-03-19" version="1">MPPAKKLTQAQKEILALYRRGLRMIKTKEQEHRRDFTIYLRYFFKHPSWGGGLRRRDFAQIEYMQRKTARLLETTFEPKSVKHINLPKDIEQDMHQLGLAHWRRSFRDAASASADSNPSPAATIPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSH5</accession>
    <name>W3VSH5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PaG_00927</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSH5"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_2_1"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="68"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="247"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="510"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="608"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="698"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="776"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1150"/>
            <end position="1239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETS64470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1240" mass="139543" checksum="934A463EAD273991" modified="2014-03-19" version="1">MADSVAYDKYMKDTFEEGPIDVDDIDVAGYSSYANGKGADYDNDDGYSEEITQEDCWDVIRAFFEEKGLVRHQLDSFNEFMSNTIQELVEEVRSLTLEQSDQHSGHAEDKTRRYEIEFGQIYLNKPTMTESDGSSAQLFPQEARYRNLTYSASLFVDVTQKVLVQSEDELDLNGDAAWVPEHGKTDVDEQQIFIGKVPIMLKSDFCWLKGLDDEMSYSLNECPYDAGGYFVINGSEKVLIAQERMAANHVYVFSKAPPAPVTFLAEIRSAVEKGGKTISTMQVKLFSRNKEKTANNTIRATLPYIRNDIPIVIVFRALGIVPDREVLQHICYDFNDTPMLEMLKPCIEEAFVIQDRDVALDFIGRRGTTTGLSRAKRTVYAQEILQKEMLPHVSTSEGSNTKKAYFFGYMIHRLLLAALDRREIDDRDHFGKKRIDLGGPLMANLFRMLFRKVTRDVYRHLQKCVEEHREFHIQAAVKSSTITNGLRYSLATGNWGDQKKAMQAKAGVSQVLNRFAFASTLSHLRRTNTPIGRDGKIAKPRQLHNTHWGMVCPAETPEGQACGLVKNLSLMATVTVGTPSAPIVEFLEEFGLDSLVDMQVAHAKATKVFVNGVWMGTHDDPGQLVDTLRDLRRKDDISHEVSVVRDIRERELRIYTDASRVLRPVFIVNPHDMTLLIKKHHVEMIGQPVPATGEEFRWTQLVQEGVIEYLDAEEEESVLICMTTTDLELSREYKQRNGNINLTSADPTARLKAVHTIAPDTWTHCEIHPAMTLGICASIVPFPDHNQSPRNVYQSAMGKQAIGVPISNILSRADSMAHVLYYPQKPLGTTRSMEHIRFRELPAGQNSVVAIMCYSGYNQEDSVIMNQSSIDRGFMRSLYYRGYMAEEKKVGVMQLEEFEKPHRDTTIRMKHGTYDKIDADGLVAPGTRVSGDDVIIGKTAPLPPDSEELGMRSKLHTKKDASISLKSTENGIIDQVLLTTNSNGNKFVKVRVRNSRVPQTGDKFASRHGQKGTVGIMYRQEDMPFSAEGITPDIIINPHAIPSRMTIGHLVECLLSKVAALSGQEGDATPFTELTVEAVSSILRGLGYQSRGLEVMYHGHTGRKMQAQVYLGPTYYQRLKHMVDDKIHSRARGPVQILTRQPVEGRSRGGGLRFGEMERDCMIAHGIAGFLKERMFDVSDPYRIHVCDLCGLTALANLKKGTYECRSCRNRTAISQIHIPYAAKLLMQELQSVNVALRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSM3</accession>
    <name>W3VSM3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSM3"/>
    <dbReference type="HOGENOM" id="CLU_1428987_0_0_1"/>
    <dbReference type="OrthoDB" id="2552182at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="182" mass="20172" checksum="5FFFAE8013F618BB" modified="2014-03-19" version="1">MFSLSSSYLCSFKNAVAASQTSSRSSSPASSSTALSIPEQNALQAVHQEQLARVASATLPRLAALHSRRFLGLAREHVKAADAMWTAQKLQPVAYRRSLWAEDIEPTPRDEGETKKRRKDARIVPDFYHRHNPRCTNCALPLVPGINLISTRKTALKQAAAARGKLRRKPICTLCNHKQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSS9</accession>
    <name>W3VSS9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dik6, novel virulence factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSS9"/>
    <dbReference type="HOGENOM" id="CLU_026517_0_0_1"/>
    <dbReference type="OrthoDB" id="10329758at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="72747" checksum="3D584F1CD349DB85" modified="2014-03-19" version="1">MQKPKGGKLSTGCSLAVKRQLHPLGGGEGGITMRRHRRRLLAAATHLITSPEPQSVSSFITQNHLFRMHATSRVSMPCMRVSLSPIVLACRLFVPDQRGACSDLESANIALGTTDGSGRSTNASRSQYKEPPPLHSVLLPLVIPSSPPTLLISFLQVEVATMNATALLDLPSVAPSLLRPITAASMTFLHRNQTEDQLLVSLAHAIYQPLPSNLRIYVLAAEFVVLFIVLVCAVMMFEKRSFGGLWIFIARPTSFGTVYVANAVFLLVGAVVVYMVAYQGIALTVAAFIMAQRSTLEYWWVIPLPWYPLVAGGWTSIHGFVLGVSPKSPFSSHQSSKAGWWYLPVPKRAWIVNSLLVVPLAAFTVTTLTFVGLGAAQCFRAKHLAKDILPAALHSQLKKAAFDPTHFAHSNALASDDLIWKARRVAAAYFDSYRFSCLNLAVFAGFTVLIFIAVLLYGLPNLISLADNACRRSATPLPTGCTSYFAKVWFLLTKGRPGHACNMNTWKMTFLAHIYVILLAICVPAYGALPIYFIAASFGNVQKGDVMQQIKSLQFAASILTVLSGTIFAVFCTAATIDPLFRAAIGLSIRRARSASTDGEISITVVQYQTRQRASTAQSIVGKDLEATCASPHSTNGSFQSLQAKSDASLAPSTAALITPVIEVDLRHPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT06</accession>
    <name>W3VT06_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT06"/>
    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="320" mass="34797" checksum="41D08527F49802DC" modified="2014-03-19" version="1">MDEAGISEIYAFAIELARKAGRAIVDGSSRRFSSAAGFDHKKNTADLVTETDEAVEALVKREISTRFPDHAFIGEESWAAGEEHALGNQVTWIVDPIDGTTNFVHAFPYTCISIGVVIDSVPTIGVVFAPFMDTLYQGCLGKGSFMSSPHHPAPRRLPLVDPTPLDDLRQALVAFEWGSDRRVEVLERKLDCFRKITGDPDGGIAGGKMVQGVRSVGSAALNFCHVASANLDLYWEIGCWAWDVCAGIVIAQEAGAAIVGSKDHAAQATQGDEFNVVTPAVLTGRKYTVIRAIDTDKAKNEQAQKHILNEFYQCITEWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTQ3</accession>
    <name>W3VTQ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00830</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002572_1_0_1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1176"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1204"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1236"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="14">
        <location>
            <begin position="526"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="728"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1308"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1398"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1466"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1523"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1319"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1421"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1486"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1531"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1567"/>
            <end position="1602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1614" mass="176047" checksum="1F4652FE58E9178D" modified="2014-03-19" version="1">MNPFESAADSSPARQGRNDGPPSLPPLTIPGGARSPPPPFHPQQPLQHHPQPGYLAQHPPQHQHHPQFPPPRSQQPPFFSPPLDAGAALPPNSNMAPGGSHQAYLNPNGPPRPAGISFQEPQRIPAQRSGPSRESVKSYGDDKRGLNDPNSSTTALNQVNTLDPESGFSAQNANFRRKKSLVRPDRERMDPNHRQWYYRNHAAHMDVIAGSGGRLGYMPSTTGHLPQHGAAPHGSGMAGIVGPGGGLSGLGVTGPSNVPPGGLGRAPPLRRGKSILGRDEDQIETGINVLKRGVSLRRKQSKSGRVSKEVPRDLGEGKSSRIAPGPVGAWMIYCYVLTICCPGPFLRIFGIRTPEQQRAWREKMGLIGIITLIMSAVGFLTFGFTQTVCGTPPDRYTLGTIDVGSMTFNGYDYSFDGFIHPQVGPFGADTIYNRTNPIYSEPWSSGGQDGSLLFQKIGAACSSLITNRAGGGQPERYFDCTLVRQDGKGGYANNTTPMCHTGSIVNQFNDGGVPANRVLRKRGQVSLNWNNVTDTTRNLAVFRGAVLDLNRLNNLTNTLAYPALFDTLKRRNDEWAGRDVTSAVMRQRLDNEFACLEQITRIGFIDSETIGCVASKVELYLSLVFIIGVVAIKFFMAVLFGWFLSWRLGNYANETYEQRMKRAAEIEQWSDDIYRPAPAGYRPNARKHKSFLPTQSRFSVADPLSLKSGSRAPMPLSEKRMTRAGRLGVASPLGGSPPGSPSVAGGRSSASLAPKGDHSRRSSLSGSPGEGAMGVCPFPLHNIVPQPGPDYRPFGFQLAHSICLVTAYSESFEGLRTTLDSLATTDYPNSHKLLLVIADGIVKGAGSDISTPDICLSMMKDLVIPAEEVEGNSYVAIADGYKRHNMCKIYAGFYDYDDETVERSKQQRVPMILVAKCGTPLEADSAKPGNRGKRDSQVLLMAFMQKVMFDERMTAFEYEFFNSIWRVTGVSPDNYEVVLCVDADTKVFPDSLSRMVACMVEDPEIMGLCGETKIANKSETWVTMIQVFEYYISHHQTKAFEACFGGVTCLPGCFSAYRIKAPKGPHGYWVPILANPDIVEHYSENVVDTLHKKNLLLLGEDRYLTTLMLKTFPKRKMMFVPQAVCKTIVPDTFRILLSQRRRWINSTVHNLFELVMVNDLCGTFCFSMRFVVFMELTGTLVLPAAIAFTLYVVVQAFLPNVPTPTIPLILLALILGLPGILIVVTSRKIAYVGWMLIYLLSLPIWNFVLPLYAYWHMDDFSWGATRVVQGENKKDNHGDADGKFDPSHIVMKRWAEFERERRWKSGTHSRDSTYDVVQRTGSPERSGSTRYSVVSSDTFHSNPSGQHDQFGRALPNPSSSSASQFAPDASEMSHAKSASGARARLDSVPLLELPAPLATDAKQRSGASPPGTVVVPRPRATSPSNLPHNSTHPALGSVHAFSPTQHSAARLPTAPSAGVYEAYPHTDIADDEKRPMIGSTSSSPDPEPRRYVGADEAVRHGNVSTEQRYPAVSESAYPMQAYTAEPESDVSMSPSAAQQPFAPSAALQSRPSTRGFSLVDDGPVANAQGVRQVQRGARRSQMPNAATSPSTATSPATGSRTSNLPPGAAPPSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTT6</accession>
    <name>W3VTT6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTT6"/>
    <dbReference type="HOGENOM" id="CLU_051532_1_1_1"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="301" mass="32672" checksum="F590C4C9BB62D85F" modified="2014-03-19" version="1">MGGTPRTSCDSSDDGDEDLPACPSALLHVRPARVVADVDEEIFLLYTLHAKAEHDGGLGYVNHSADRIFVAIDGQRWNSALSARNLSDAVAVHQDVTSLRSTKGNTGSVLWRSTVELAIRVRTGALFDLAALRDASVLELGAGTGALPALVGPVCKTWLATDQHDLVALLDKNTDALPGVHTAQLDWFDFYNPPSSHTLQIRRSDILNRLHSTTNAHGAVVDLIICCDCIYNPALFPALIATINAFTTPSHTLVLVACEMRSHHSLADFLHEWQASDAAWMILSLEKRFDKGFVTLAAWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTU6</accession>
    <name>W3VTU6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubinuclein middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTU6"/>
    <dbReference type="HOGENOM" id="CLU_384072_0_0_1"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="3">
        <location>
            <begin position="338"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Ubinuclein middle" evidence="4">
        <location>
            <begin position="503"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="763" mass="82639" checksum="91AF75835B9A0FD3" modified="2014-03-19" version="1">MPLIVPDVIEIGSSGSSNRASSPIPELTVTKMNGRSIQPHEAEDEEMPRSSAASRVSLANLLGPSGPGSSPYSNTPRTSPRKRPSTDSPGTGLQPPTDIANGGSSSSSSTTHSEGRERRRSDAASQQSPARAEPAPDAAPAGDGSTSHDVPTVDVTEPDGKAPGDRDDDEDEDDEDDDDDDDDDDKATTDAGSASEAEGEDKAEGSSAKDGAGSGEKSIVPKKRSRRRSPSPPEAATAPPPPKRPTVRLSILEARQSGYLINVPELVLAKLKGQDHPWAKWYEEQLLEAAEPEPAPPQAGPEAPPDLEGFGSLARLLAKYPAGEGSAASAGASGASKKRRKVNDDKYDIGQYDVRDPFVDDSELNIDEPTHFAKPKADGFYVTQGTVELAKAKAMGKGQPLLGKDRPKPLSIRDSKFGFAGSLNKLVAKKAQQQAELPPMPASSSMQLGSLLNNGDPGSPAMGAGSALTNAQRQAGTRDSPIKVDDNDSGSSKNAAKKNRYPTEPVDPRLQASFDDLKSKVDAESFAVKTKFPAALKPPLIETAKLAVMLGEYDDNFFNHLPTIFPYNRFTMMKLVKREFFPHHIKYFEDLKQEHMDKLGRMIQESFPHQLAEFEAAHKAWVERGEAPKEGEEAAPKPATAAEGDQSMDVDGKEDDESVEPTKRWKWSEEMREEVFVLITIENAMSEIRNEKYKLENSAEQYSEINARKACYKQMAELFPEDGWTTSTNISREYAQIKKKKDRQEARGEELFGDSRASSAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU08</accession>
    <name>W3VU08_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly A polymerase head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU08"/>
    <dbReference type="HOGENOM" id="CLU_019592_2_1_1"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="6">
        <location>
            <begin position="103"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="719"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS65044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="755" mass="82733" checksum="03448AB70F747096" modified="2014-03-19" version="1">MSLSYIRSCTLHRSLIPTGLLRSGQSSGLPRRVSTPATRIGSATQRLVKSTMRPDAQIQLTEQEEAICQLLDHTCSYIQREKPEIEGVDATQRSGDGSDPCEARIAGGWVRDKLLERDSDDLDISLSTLTGNAFALYLKHFLSSPSFATSSLAQSPYFREDGHEMGRIGKIAANPEQSKNLETATARVLGLSLDFVNLRKETYDPGSRIPTMTFGTPKEDAERRDITINSLLYNVHSRQVEDHTGLGLQDLASGLIRTPLPPLTTFLDDPLRVLRCVRFASRFAYELHPAIIRCLTAAGDAETGPVQLASADDPRVSTGNRAGVESGRDQIRDALVSKVSRERFGIEVDKMLKGPHPLLALFLLHRLELFPLVFHPQPSAGKLWVASEPPLRQEGAPLADAVALNAARLLDAILKQSTLDAAPINQDVAMHSLTLADASGNAGNALGKTDLSREFSALPASLLPKAVLEALPSDLVASWSSAALSSEEKRRLWISVALLPLRELVYEEKKNKNAWAGESVIATGLKLGTKTLKEPVAAMHKCLELLPLGRRALCRDAPAAQDTEALDRALHLPPGLSVRSRLGLLLRNPNVSNSMLQLRPQPALLLSFIGETIELWRNSEESFNSLDANLGGVQDRIVELAREYAQFWTLVQQWNLVERADEKPLLDGNAVTACLGCHPRLISQVQTFVLAWQYDQPSSGPALEAQCSEWLKAEWAKGGIVPVDQRPPPPPSKADKAKKKPAVETPDRRKRQKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUB0</accession>
    <name>W3VUB0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NBP35</name>
        <name evidence="9" type="ORF">PaG_00551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUB0"/>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="367" mass="39015" checksum="27328CA56610A605" modified="2014-03-19" version="1">MLAVEHPPTSALASTALGAESIARALPDQVPENAPAHCPGTESEQAGKADACAGCPNQDACASAPKGPDPDLPLIQQRMSRINHKILVMSGKGGVGKSTFTAQLGWAFSSRFSGSYDEDQKHAGEEEKEKQVAIMDIDICGPSIPTILGLAGQSIHSTSQGWSPVYVSDNLCAMSIGFLLPSASSAVIWRGPKKNGLIKQFLKDVDWTAGLEDEDAPTDSALIDFMLIDTPPGTSDEHLSIVSYLKDSGITGAILLTTPQEVSLQDVRKEISFCRKMNVPILGVVENMAGFVCPSCTGYSEIFYPSTGGAKALCDELGLRFLGSIPLDPRIGKSCDLGVSFTDEYPDSPATKAYLDVIENIHQLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUB6</accession>
    <name>W3VUB6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="10">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUB6"/>
    <dbReference type="HOGENOM" id="CLU_031922_0_1_1"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS65208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="482" mass="51735" checksum="B3B579EA4D35A1A7" modified="2014-03-19" version="1">MRSSASQIAVFPPAVSKRRPAESLEPHPGTEPTPGFLPFVPNVPIILSIPPFSRSDSMIAFARTALRARASAAASAAAAAPRPAALALRCKSTSVSHDPMTGEAAGTKHLDASSLVVTRSNAPRTPPPSQSLVFGANFSDHMLSVPWNSATGWDAPKIHPYAPLQLDPSAVIFHYAPSLFEGMKAYKDVNGQTRLFRPDMNMKRMNTSAARIALPTFEGEQLITLIKKLVALDKGWIPSEPGHSLYIRPALIGTEAALGVHPTKDALLFVICSPVGPYYKTGFKPVALEADPNKVRAWPGGTGQYKLGGNYAPGILPQLEAAKRGYQQNLWLFGEEHLLTEVGTMNLFVALKKGDGVELVTPPLNGMILPGVTRDSILHIAHDHVEGKYPLDSLPKNLKVTEREISIHELIQAEKSGELIEMFGAGTAAVVSPVDRVGYMGKDIHIPAGDGIGPIAKAMLGRITDIQLGKVDHPWSVVVEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUJ8</accession>
    <name>W3VUJ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUJ8"/>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="30"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="410" mass="45097" checksum="5EFF55D4A6695C30" modified="2014-03-19" version="1">MTTTSDRSAALQKHAQKVLDTYTAGKGPNNVPGAVAYVSDKSGKDVIWAHAGVKEVDKQDPMTKDTIFWIASCSKLFIAIACLQLRERGQLDFNDSIDKFLPEAGQLKMLKDGSKPNKIPTVHDCLAILSGQACALFNQDLADWFQSKGLPPTANLDSTRASLFTPYASQPGEEWNYGFNIDWAGMAVEVVTGMDLESYYRKNIFEPLGIKAITFKPRSAGLLDRLAGSHMRNENGEVIPFMQLLLPEEDKMEAIYPGAGLFANGAEYTKILVALLNGGTHPITGGTILKPESIELLKKDQLSGKLVDDLEREFDQVIPAVISKGFRGCLAPGIKKNWSYGGLRLKEKHPTRGHSDDTISWCGVQNSYWWCDFKDGTCGMVHAQMSPFPDKATENMVAEIESQVHEAYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUM3</accession>
    <name>W3VUM3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin motor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00987</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUM3"/>
    <dbReference type="HOGENOM" id="CLU_001485_3_0_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="4"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="901"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="624"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="949"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="964" mass="106981" checksum="DA259C9259182B4A" modified="2014-03-19" version="1">MSNNIKVVCRFRPPNAIEQREGSDIVVDFSQDGTLVKMTRGASTSGPEAGGFTFDRVFPMNTMQRDVFEFGIKETVDDVLNGYNGTIFAYGQTGSGKTFTMMGSDIDNDNMKGIIPRITEQIFENIMASPPHLEYLVKVSYMEIYMEKIRDLLAPQNDNLQVHEEKNRGVYVKGLSDFYVGGQSDVYEIMRQGGLARAVSSTNMNAESSRSHSIFLITIQQRNTETGSAKTGNLYLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINALTDGKSSHIPYRDSKLTRILQESLGGNSRTTLIVNASPCVYNADETLSTLRFGVRAKSIKNKARVNAELSPAELKALLKKAKADNERYQQYIANLEAELKTWRSGGKVPESEWADASKVVVGQGAPVAAAPASTPSLTPSTQSRPLTPAVENLRELASRPETPSVVSIDKDERDEFLRRENELSDQIAEKEVALKSAEASLREATQELAFYREQEASLSKDNKSMTSEINEIKLQLERVTYEHKDATITLDILKEQNKDLSAELEELRKSLADTAKSAKDPSQEGKERKKAERMAQMMADFNQGIVSEKEEQIRETLAKLENAGSAGSGALSADDLSMLREQLLDSQSLVREQTERVRQAHEENELLHQRRQELESRFATLEAEYEELLDKSLKAEEANHVNVDVTVEDLKAKLESQYASKREAQASEITDLKRQMELKAKEIAVLTSSNDNLKSTNEELKRAFAVTTAGVEGGRNLAESARELERVRKTMAAQLSEFDTMKKSLMRDLQNRCEKVVELEISLDESREQYNNVVRNSNSKAQQKKMAFLERNLEQLTNVQKQLVEQNSSLKKEVSIAERKLLARNERIQALEQHLMDSQEKLMLQNRKFEEQLQAVKERLHQANQMRGPAASAAPGPLGGFGRIAKPLRGGGPTAGPQPGSVAARQAAFGGAGANDNSPKARSSWFFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUQ4</accession>
    <name>W3VUQ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Alpha-galactosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01023</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUQ4"/>
    <dbReference type="HOGENOM" id="CLU_013093_1_0_1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005995">
        <property type="term" value="P:melibiose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000202">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006215">
        <property type="entry name" value="Glyco_hydro_melibiase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00748">
        <property type="entry name" value="MELIBIASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833432" description="Alpha-galactosidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="13">
        <location>
            <begin position="335"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="473" mass="52454" checksum="54BE64819B42F078" modified="2014-03-19" version="1">MVSTTFAALVPLALAGFASAYNNGLALTPQMGWNTWNTFACNISEDTILSAAKSIKSEGLDKLGYNYVIIDDCWQADQRDPDTKEIPANPEKFPNGLKPIVDEIKALGLKAGIYSSAGTMTCGHHIGSLGYEDVDAKSWSNAGFEYLKYDNCFNQGQQGTPKISFDRYNAMSQALNKTEGDPILYSMCNWGEDWPWLFAQEIANSWRISGDIYPSFNRDDDRCPCTDITTCNLQGFHCSVAKILDFAASLGQKAYPGAWNDLDMLEVGNRGLSLDESLVHFSMWAMVKSPLILGNDLTKMTNQTRAIIKNKHVIDISQDPKGSPATRMWKKQESDGNTQLWKIGLSNDTYAVAVINVSESPKNMSISLDDVFYDEYLEGEDLAQQSWTAYDLWKGVDFTKNPTEPVAMDKMLVGTVSGSIDNVTVPKHGIKLWKLVPQQGQESAQKRSADGLDRVTRDFAEMKPSRIMGSHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUW3</accession>
    <name>W3VUW3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUW3"/>
    <dbReference type="HOGENOM" id="CLU_016972_3_0_1"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833437" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="190"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="510" mass="52662" checksum="37194DA2621E732D" modified="2014-03-19" version="1">MKYLAALALAFAASISVASAGPEGPVAVPPGQGRSSRGVRSVITGHKIRSHVHHSRRQHHNDDLVLLDRRLNNATINADDEEVAAIAAAHNKRNTCTPKKSAAKTSNAYRVKGGSGSGSSSSSGSSSSSSSGSGNGDGSGSSSSSNSGSSSSSSGNGNGSSSSSSSSSSSSSSSNSNGSGSSSSSSSSSSSSSASTSQWKLVKSYSGSSFFDDMDFYTNADPTHGSITYVGQDQARNQGLIGTNNGKATMKITPGNGWAQSVRINTKDSFTTGIFVLDAEHMPVGCGVWPAWWSTPTNPNGGWPNGGEIDIIEGVNDYSYNTYSIHTTGGCTVPANPNMSGKFTLQDSRATNCASDATGNQGCGVTSTKGGDFGVQYNKNGGGVHVMYWSESDGISTYFFPKGQVPSDISSGSPDPSNGGWGTPMAHWPASQCNIGNYFYNHVVVFTNTVCGDWAGSGAVWNNAMNGQSQSCQAMTGQGSCQAYLGNNPDFSEAYWSINSLKIYQTSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV37</accession>
    <name>W3VV37_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV37"/>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_1"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="295" mass="31391" checksum="9C61AFAE8ECABE57" modified="2014-03-19" version="1">MLASTVRTALRTSTPRATLPSTRSLSTSLPRLSAAAAKEYQNILVSSPAKGVTLITLNRPKALNALNSALFHELNEATEIADNDPEVGAIVLTGSEKAFAAGADIKEMKDKQYADAYKTNFLGHWTKLTTVRKPIVAAVSGFALGGGCELAMMCDIILASPTANFGQPEINLGVIPGAGGTQRLTKAVGKSTAMEMVLTGRNFSADDAERRGLISRVVREGSVVDEAVKVASTIAKKGQIAVQAAKEGVNASFELSLQEGTRFERRLFQSLFATKDQKEGMAAFAEKRKASFTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVG5</accession>
    <name>W3VVG5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVG5"/>
    <dbReference type="HOGENOM" id="CLU_370954_0_0_1"/>
    <dbReference type="OrthoDB" id="2554329at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="705" mass="76576" checksum="4441B66512A6914D" modified="2014-03-19" version="1">MVDVLAAEIRSSARRGPHHGTKRTLDATDTAPKRRRLVHIGSSPPPYSTAYSDNPGPARTATAPVSPRAESKRNAPSTRSRNALNLRASSLITSPPPVPPTAVTPDPLPRPKRRGAQGDVAGDQGLRMQTRQLQSLRTLACADPDSPIGTFGGQILPRSIRDTTCKGRRASRAEALTTDALSRGNHPHLAPAGGRTTSKRSVDAKANNADSADAKQEGKLKRPAEGRTVKQRRRQPKIQRVQFGGVQALETHYPLNEAHSRASVPPISDDSDAADESEITYFPTLPPKRPHVGTHMQTVQTADASSPFLDNRPSLSDAASSPRPLLAPDDATRDYGDPESEGDSSRGLLEVLSQTALRRMNDANSPQQSQHVGHAHANQAAWQTLSRHDIRIEFDAAHLSHLQARRIAGSLTRNGSDRPKWTSVQLDSDHPRRLKLPTSTLASIKAVRAAWYPPTRRSVCDDLCLTAKQASQKAGSDRLEFVHFDSGELVHEEPSEDLENLPAFEHRIHFAGYRLQMQVPHDAEPSAFPCLESFDGEEWPTRRGPVVKILVPLSGPSLHPAASPARFIKPHDTRDEALGPAANDTVLVWTSTTARRFLAELDDQVATGEVSSYAELRGLEASELELCPSPILHYMASTGSPGADVSRSHIALYVHAHRVQEARSVLATLELGDMLGGAPHKFRPFGDPKLRLLIVSMVGTPLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVI4</accession>
    <name>W3VVI4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVI4"/>
    <dbReference type="HOGENOM" id="CLU_005479_0_0_1"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF90">
        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="225"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="824"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="912"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="912"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1001" mass="106845" checksum="FCE7CEAA5CE93C07" modified="2014-03-19" version="1">MYTSRASGLTRRRDFSLTPIQYYPPTKSSLTSPALNPSPTSSIRPACSNNRRQSSHSSASKPARARSLRNLAILLLASFAFLAASFVLPAQAYVVPTSPDQPVTAAISHDDRFIASAHLDRASVARSSDDDADYSFLPEASTSPTAEWIKLQIVSDHPDGIVSQAFLDELYERLTFERRSDAASQVVPEPLLQGGASKPPSSRRRFWKRATSSGSGETCGETKLSKGQKAAYGILIPILVVLSGLFAGLTLGYMSLDETQLQVLALQGTPKQKRYAEKIMPIRKDGHLLLTTLLIANMITNETLPIIADPLLGGGVQAVIVSIVLVVIFAELIPQSVCSRYGLAIGAKLAPLTRAVMLLLWPIAFPVSRVLHWTLGPHHGIVYRRSELKELVNMHAATAGRGDLNNDTVTIVGGALDLQEKVVKQAMTPIDQVFMISIDSKLGYETLQQIVSSGHSRIPVYQEIEIPLNRARGGSGTLTPSRGGGGFFSALSRKASISQTKTSIDDQRTLEGSVSTEKEASAQDFAVPNAPAGDKANPAANTTATTMIKRKKIIGALLVKQCVLLDPEDETPVRDMVINALPTVPADEPLLNLLNVFQEGRSHLAIVSSRTRRSSPGSFVDLGSQNDPRKTQNLARSGTAARIETLGNIDEEKQLDDSAIKKSSFWSRHLRRHHRHQNKSASLDLPPEALRDDVDASAVATEMAQRDVPIGIITLEDVLEELIGEEILDEYDSEVEQNFAQISPPASPGHKDMVNKQTEAPSDAEEMQLPGAMLKLPTSPKIPLPRFKLGRSVTQKDVAVGATPGAETVALPATPVTESRAVLPATQEADASEPSQFPFDAVERGAGSRPSSRPGSRPVSPGPAAVLGTSSDAQLVAPRANKPVVIRHQAPDGTIATAIVGEGLLRGRTNTLASERTASGEVSRSTTPSGTRVSRFKSTPLPGTPAAGVAPRSKTPGKPDFGSSLAEEVGSAAAPVASPEELDSDPAKKQLGGDSDDTDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW06</accession>
    <name>W3VW06_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00409</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW06"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_2_1"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="185"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="408" mass="45563" checksum="4F53A96FFA8E0885" modified="2014-03-19" version="1">MADPTPSTSTQPPAESVLSTDPAKDKALKAYKKALKQHEELSEGLKKLRFGLKDLDKAYDKTEDDIKALQSVGQIIGEVLKQLDEERYIVKASSGPRYVVGIRASVPKHKLKQGVRVSLDMTTLTIMRILPREVDPLVYNMSMEDPGAASFAGIGGLSDQIRELREVIELPLLNPELFMRVGIKPPKGVLLYGPPGTGKTLLARAVASTLETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDYLGKTKVIMATNRPDTLDPALMRPGRIDRKIEIPLPNEQSRLEILKIHTKPVAKKEELDYEAIVKLSDGFNGADLRNVATEAGMFAIRDDRDYCVQEDFMKAVRKLQEAKRHESKIDYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWG0</accession>
    <name>W3VWG0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWG0"/>
    <dbReference type="HOGENOM" id="CLU_555475_0_0_1"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="316"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="580" mass="64155" checksum="24056578AC32E958" modified="2014-03-19" version="1">MHATASGPTLPPSRAEPPRIPKWSSAAALEPTISQSTSQRLQLDAVSRAPRSSNPTTVPPSIESPAQRPFGQARPRKTSLRPVSEEHITMSSSISVSSSASTERKVDPRVLAAIQKASPPRPAVLNPLLRMLVFQVFFLSTSLVKIPWYLLRSIIPRFRLNPNWSFATAAYILVVRRVMRNLIRFGVQPIAPRKGGLRDRNHFLGTLVACLNLSGPGGSVVLAKQSIKALKLDAKHGRADKVWIPPAGPEYLDGILAVKTSPNDKRRITTDAYTGPPLLDPKWLKWSIRALWFTHKPEIVPPQPRATTKPSRPVICYFHGGAGVTFNAGDAHMGMNLAKTFARNAGIDLFSVDYNLAPFAPSPVQLYQAVSAYLYLINELKYSPEQIYIGGDSHGSWMTLQLERYLRSYKHVVFDDPASFKIPGLVLLSPWIAPEDLSFKSREKNVDTDIIALSYEEWGVSAQGLKKLPYPLSDPWSTHSNKSIGELAAMPPCFIANGGGETLLDEGTHFANLMRKAKNLPTSTSSQRIVLSPGELNCKVVHHVYPHEVHDYFTVDTEVANAIKVYKQIGTWIKFTQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX16</accession>
    <name>W3VX16_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX16"/>
    <dbReference type="HOGENOM" id="CLU_1267741_0_0_1"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="215" mass="23847" checksum="1C84D7216C787672" modified="2014-03-19" version="1">MLGDAALKLVTESKACLNLDTVKPYNDELVRMLVLETKQLHTHMQSLLSLLETSSPVQVAGLQSQLLMLHLVVQTNKRALLIYHNVRTDLLTSALNSAHSLPTLLARSPAIKAGLAPHEIEYLKHYAALIQTVKVDYMHAAPSLQLDIMDQHPDERPPTNLLVTIKVLKPLNDVWLSHAQSAPSSFQKDQTLTISHADVRPLINRGWVALVDSDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX42</accession>
    <name>W3VX42_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX42"/>
    <dbReference type="HOGENOM" id="CLU_094309_0_0_1"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="178" mass="19527" checksum="6A8587CFB6FA75EB" modified="2014-03-19" version="1">MTLTNEQFLEQLAKLFEQSTSKHSVYITSKKAPASAAQDDDVDMTPSSSSSSLKDAILFRATDGSSGSGKVKISTLVPASKLATFQGAYLPLLRTHLSAGLRKRDKAKERKIEKAREQSRKKLVETVDGKEKVITNKIGSKRGAGRRKRQRALNKGLALRKEKAKEAKRKQQTAKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD16</accession>
    <name>W3VD16_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_06452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD16"/>
    <dbReference type="HOGENOM" id="CLU_1023504_0_0_1"/>
    <dbReference type="OrthoDB" id="10383251at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS59533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="272" mass="29377" checksum="7C64F21B6CFFF5AE" modified="2014-03-19" version="1">MNSKYIYPVGYPAHGLFSTATSPTSSNDAGVDIIDRHAAVDLLGNQTPTLGGRKRSDSSVAAVDLLGNPTPTYGIRKQSASPVIPANGQCPSAEVPAPVNVVAEVSAQRASVPPSRYAYLLRRRERASASSAQAEMWRITRDGPEQIPLSSRLQFTPLDEIDDYGNNESVNVVATVASVEGLIQPMTCPFWPVAITDSPGHTRTLRVFLRHEANVELQVPLQALEPDDVIIVLQASVYNGSLSAFDKTSILIAKDRESGRPRLRPLPERLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD77</accession>
    <name>W3VD77_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_06527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD77"/>
    <dbReference type="HOGENOM" id="CLU_045276_0_0_1"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF24">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="55"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS59603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="410" mass="43964" checksum="7843D8D28F5572C4" modified="2014-03-19" version="1">MDDGASGSALSALIARIEAYAADPSSLSVPGSTTRHAVWLADEAQRIEAATQLAEELVALQSIYTDDAIFVLKISPLGAEARPNADDADGHEDAADPNTWLPGAKLTLSISADVEAQTTDGEPIPIRLAVTLPPFYPHSARPPQLQLLSRYVGGFSVDARLFGEILRAFYHQTGESTEPVDAEEAASANWIGGSMDRGVDWASGQVVLFEGIEWVKEKVSDWWSDKETERIKSAPSPSSRLPTTTASDPQVTTFADAPGQGQPAPFEGHIFRTESIIERKSEFIGHAACITSPDQVASVLSRIVSDKRVARATHPIINAWVCRGADGVVHRDCDDDGETAAGGRLAHLLSILELENVLVVVTRWYGGVHLGPDRFKLINRAARDALDLAGLVGKNTDDTAKTKGMGKRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDB2</accession>
    <name>W3VDB2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDB2"/>
    <dbReference type="HOGENOM" id="CLU_012430_1_0_1"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03143">
        <property type="entry name" value="A4_beta-galactosidase_middle_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="BETA-GALACTOSIDASE GANA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE YESZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834352" description="beta-galactosidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 42 N-terminal" evidence="9">
        <location>
            <begin position="73"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase trimerisation" evidence="10">
        <location>
            <begin position="496"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="786" mass="87904" checksum="0542177FFF80CAB8" modified="2014-03-19" version="1">MLASNWTRLSAFVALLPAIASAIPARDFDLDATNLFSRDYIQPDVDNTKAYPFSSTKQPDSSRWPKGLHFAVDYYPAQWPEFLWEDDAAKMANATLSYARISEFDWAILEPTDGTYDWSLLDNSIEALHKQGVKVILGTPTATPPIWAVKNYDILGADAQGRVRKFGSRRHYSTSSPDYRMLSKRFVEAMAKRYGQHDAVVGWQIDNELGCHGTVRTYDNNARTRYQQWLADKYNNNITLYNEMEGRVFWSSTYQSFDQVDLPMLEVTESSPAGRLDFYHFSSDMTIEYAKTQVDIIRKHSDKAITTNFMGAFLDFDHFKLARETGIDLATWDSYPLGNTEQFAWISDSDKVKYGRTGTPDFQALHHDLYRGVAGAAYNKTAGPFGIMEQQPGPVNWAPYNPSPKLGMVRLWQHETFAHGGSMSNIFRWREVPFAQEQMHAAMLRRDNVPDHAYLEQQQVVHEDLPKMMSLFESNDSQKRDVADNAPVQTKTEGQADVALVFDYAAQWLMEAEPQSGTWSVDMEGFESPSMQYFPLVLNWYSALRRLGLNVDVVGPSTPLEGYKMVAVPSMPILSKEFVETWSNYKGVSVFGPRSASKVAALSIPDGLPPSNGPVRDVLPMKVTRVETIKEGFGDMISYGGQQYNVSGWVEWIECERDGKNASVSIYASATYYGYRDGAPATCGNKDGDKQTHYVSAYTPVEFLVSYLGDIAGSAGVKTLFGETPQGSKTDLGKDLRFRRNGNALWAFNYGPDEVDLPAAPQGATLLVGGEDGKIGATGVAVWSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDB3</accession>
    <name>W3VDB3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trehalase</fullName>
            <ecNumber evidence="2">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDB3"/>
    <dbReference type="HOGENOM" id="CLU_006451_4_0_1"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833068" description="Trehalase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="797" mass="86663" checksum="4BC17E065E962335" modified="2014-03-19" version="1">MRLPALKTLALLLPAVAAVAAQDASSSMSASSASMTGSSTASSASGSSSLTSTATASASSSGTATSGGAASSSSVNPLTEKPPAAVPSATTTPSAMIPSGPLPPSQELCTSPIYCPGPLLQAVQLAGIFEDSKTFVDKATSKPESEVLDNFNKLGGGNTSNITYEEIVQFVDDNFVAEGVELVPADLGEEFVQDPEFLQGVEDEVVRDWLKQVHSYWELLARTTNSSSPSGVQCDGCVSSFIPFNESRVFVVPGGRFRELYYWDTFFVIEGLITSQLQSVVKAILENFGDLIDRLGFIPNGNRVYYENRSQPPFFTLMIDKYIEAYNDTSVLQRFLPLLEKEMEFWRNNRTIEFTSPFTNNTHNITHYKVDTSAPRPESYLEDYKTVEDASESGLELNDTQKAQLYSDLASGAESGSDYSGARWSKRPTINLTDTIPAQRFLNTAQQLPVDLNAILFACEQKLSAFYKVSGNGTQSNMTRANYWAQQAQARKQAVLDVFWDPSRKFFYDFNVTLGDRAPYYTPAGFFPLWAQILPQEFVNETISLDQRRQNLQGVFSGLRYIIDRFNGTIPASLVTTGQQWDFANAWPPHTYIALEALRNLPDSLSAGPQLPAENGTFALIPMTNGTNQLGQTQDSLPIQPIEYQPGSMINETQAGATDPNNPEQELNPIMNVGNSTTGESWRDELVRELANRYVASALCSWRATGGKLNTTDPNFQAVPDDVLTANGLNASTAIGNMFEKFNASDINAAGGGGEYEVQVGFGWTNGVAIWLGGQLGANLTRPECPPVVAQNTTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDQ5</accession>
    <name>W3VDQ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_06611</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDQ5"/>
    <dbReference type="HOGENOM" id="CLU_021859_2_2_1"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="18">
        <location>
            <begin position="312"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="17">
        <location>
            <begin position="457"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS59679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="744" mass="80654" checksum="DEBD01C7C7F6B283" modified="2014-03-19" version="1">MTINAHRSRVYSYRCSAALVLAMADATEAAAASRRQEELQKQERHADIKHLLTPLLLRRQKVYNAIATPLEAPLITHAHGQHAFFPNLDAKAALQDVQPERVACSQTMHKATCRASDTVTMRCTSSKAARSEAEGEVGGEAKHVRFKGPHRVKVRLWGGVGRGGDGGLGARQRASARERPVWRRATSTTASTFPPPPSSTALPFAASPAGSIRPYRCVASAPHPCSMYRPLPRAVSALPKRLTPASARSIVTPCRPAIASSLPSHSVSIGRLLSTSRASRAEAAAKPAAPTASSSASASYSDGGPAVPGVTMDAKSRAVYITWASGITSKFHNIWLRDHCRCPQCYHPTTKQRLLNTFEIAPDAQPISAEATTEGLLVHWPLLPSERAAQPATPEPAQGTEEAAGESAAGPQHPSLYPWRWLMRNSYSPLLSDPVTAASDDTGLKGIEKVLWGKGIGSAPPTVKYDEVMGSDEGVLKWVTKIAQYGFAFVSGVPPTPTDTEALIRRIAFIRETHYGGFWDFTSDLAHGDTAYTDLALQAHTDTTYFTDPAGLQMFHLLSHTASKTSSSGTKGPSGGESLLVDGFLAAAVLKDVHPDAYDTLSRVRIRTHSAGDENTMIRPLLDGGYPILQHDEATGELVLVRYNNDDRSVLRVDADDVEPFYDALKKWNAILTNPEGEYRVQLKPGTPLIFDNHRVLHGRAAFVGNRRLCGAYVNHDDYRSRLAVLRTQLAENRSTRGVWDDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDS7</accession>
    <name>W3VDS7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDS7"/>
    <dbReference type="HOGENOM" id="CLU_2039036_0_0_1"/>
    <dbReference type="OrthoDB" id="2555807at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="121" mass="13479" checksum="2924EFD64B9646A3" modified="2014-03-19" version="1">MTDMIGFLVVITGYKTIAHARQGNYAAHRTWARFHTYAGFAIPVQRACQGLLFAVAMLIPLLPKSILQRFDYPSSDEAIHKAELGSQGLAVLLAGITSAIIVYRDVFRRPARREHAKPELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDT5</accession>
    <name>W3VDT5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutaminase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDT5"/>
    <dbReference type="HOGENOM" id="CLU_008020_1_0_1"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834046" description="Glutaminase A" evidence="2">
        <location>
            <begin position="27"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="4">
        <location>
            <begin position="243"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="493"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="925" mass="101824" checksum="574B88C83BF6394E" modified="2014-03-19" version="1">MRLSFASTASTLAAALLLSGPAPAQASLAKSSDLKTLYEALADITRAPSEKHLAQGQQLVGLSSDPAQPGVQWSVQQAQQVVLQSGDLNAPSYKLVTNGEKTAGSSAASPAAASPASTSSSGSSNSNPGITNADSALSSSSFSPVNPPSFPLAVRSPYLNAWLPSGSNRASTPPNTVGDGGYLAGQWPAFWTSSYGADGEFRLGWTGYIRIDNVTYEWMGNGFGTLVRAGQAAKQLSAQYTATRTIFAFEADKVRFNVTFLTPITPNDYLRQSLPLSYLHVELDTTTIKGRSIQLYTDIDERWVTGHDYDYEDFPYDQQYYEKNDTSVFFVTRKHPEVYTEFRQRAEWGNATYAARNHTGLYSRNNNNIVTHTEFIDTGKLSFDHGPVLGPDNSFAFAVDFDAKHADKDALFVVGHMRTPYVNYIRAKNPGTNSTKSYQEDRYGYWQSEFGDKLEDAVAFFMNDFENALETAKAFDKQVADDSRAAVGGGAVGDKYAAITQLSVRQAFATFEITISRDSKGRYNTSDTLLFLKEISSNGDMSTVDVIFPLFPLLSYANPNLLRDLMKPLFEYTESGLYPNKWCVHDLGVYPNAFGHNDGNDEPMQVEESGNMIWMTLHWAQLVGKSKALPFLEEHYKIMKQWTEYLVADSLIPAEQLSTDDFAGTLANQTDLAIKGITGIAAMSRIAEMLGHSKDAKSYANISTTYIKQWQTLAISHDASHTKLAYQTDASWGTLYNLLADRMLDLSLVPEAVYKIQDAWYPRVQEKYGVPLDSRHKWTKTDWEMFAAAASDDPATHKLFIELLYKFIEDGKTDAPFTDLMESTTGDFPKQPEDPLIHFLARPVVGGHFSFLAKSKADKANGVASGAYKYGNDNDVISNKTSATSEAAGKQAAFQAPMHVGTPDERRKKSNSLSSGSQRAFQIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFA6</accession>
    <name>W3VFA6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05512</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFA6"/>
    <dbReference type="HOGENOM" id="CLU_012540_0_0_1"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000039">
        <property type="entry name" value="Related to zinc transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="713"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="556"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="827"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="935"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="982" mass="104865" checksum="88348C759E61AB01" modified="2014-03-19" version="1">MPASFQGRAKKIGIAAPTRLTTTNRPTTLDHTLHSAGESRAVLALQAGILTVTRAPVGKAMSSPYTTTPDARSRGKVRMEPLASPSRSTSAASSSLLGFPIPTDLLLGLLLNKTLLASAALLVRSWLSSTHTETMHSVLASDVSPAGTLSDLTSLIGTTWAARAGPSSWAIATLVFFIAALVQGVWFKAWQWLPAVKRVDKRRLCILAAITFAQLLVWLMALRKLDAVNVIIFTQYCEIWAVDLAKSLRGRSYGGYTTLFALAISFLSSISNSASLPSSTLDYPVHILEMYADADLPDSLRRNRPAGLASPSQLRAASAAVEASAASFSVFGTLTGHAYLLIFALLTIEKESALLSASRDTGGRRRAGIVATIVASAFTLPASLLLGLFGFSTLPSLDSLLASTTGSTTTSMGHLPAYLAISFGVVILEPLVSTSIESHASTKDRIAHGWPLAVLASFAIGFVGFGYRPQWSQIVVALLVGQALRTILKNSPDHASSRFSSSDAETEATRSGSVAAKTPDVSALQELVESMSSAATATRRTVKVILANPDSRKIFQFLMLNLAFMGVQLLWGVWTNSLGLISDAIHMFFDCAAIGMGLFASVMATWPTDSTFTYGYGRVETLSGFANGIFLILISIFIVFEAVQRIIEPPVMNSNTQLLIVSSMGLAVNLFGMWATGGHHHHGHSHGHGHDHGHGHGHGHDHGHGHSHNMMGVYLHVMADTLGSVGVIISTLLIGQFGWTGFDPIASLFIAFMIVGSVIPLVLESGRILCLEVGEHRETEMSEALEALRSINGVVSYHSPRFWPKDAETLVGVIRVQVVWPLDGEHAHAHSHDHKRDHSHGHDHNHGHAHHDYKHDPSHGHGHTHGHTHGHDHGHDNDHDHDHEHGHGHFHASEHASSTAVTPEAMARAIENALKARIHGLDSVAVQLEKVASGATATGSPGGATPMSASPSYSSAYEGSPLAVRSNGAHGLSPITAHRHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFE0</accession>
    <name>W3VFE0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFE0"/>
    <dbReference type="HOGENOM" id="CLU_019790_0_0_1"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="647"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="158"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="772" mass="80124" checksum="23A55784ACECB8FE" modified="2014-03-19" version="1">MSSASTASLLPSPGPSSASISSPRSVAPRLAASPSSSSLSSIKPAQPRSHSSRIEPSPLASAGQALRAAPSAPATSSQSPVKRKLSTSNPSLAAASIAPAATAAPSVPIIKKDTSGPLVQPSKEWVLPARAKPGRKPSETEPLTKRKAQNRASQRAFRERKQSYLADLEAKVAAYEAAEIDRSVEIQKVAQKLSSENDTLKKELAVWRDKYAQLEKLLMHIRATGRVPNVVPSVKSGPGCKAPAHEKSGVVPKRGVLVAPGTKPSKDKDRSAGGVRFAEDSPSQAQSSPAESPAASVPLRRRPSATSSASPQVSSSVVSATSPTGTSASSATASGPVQVNIEKPVSITSAPLPKGVKPPLWSFEQPHPSSSSVGHDAKSDKTSSLSSPSLLPEGKHLSVDGGCGFCTEASPCVCADDFLDLPSDSQPSHIAVTSDVPSAVPLPKHSNASTSSSSTSATSTARRMSIGSLTHAKDVNLDQRKRGAGKLWYTVNQPDSPPRAPTTDGTAAPLKIRRPTSSSKAGKKLWALAPAVEPVCTGDPSTCGACQTDPGLAAFCEAVTTAASAPSSSTSTTPPSGVSASPTRPGMLRSGTTGRLGPSSVYASTAQTGGETIPSAWRQIRSHPRFAQWQGGLDLLAEVVSKRSGNVRSPLLSNRSREDSVEFEPPTSATATTSMATSNDRATSKPLLLHTASDTTIHAPSPVKREQREEDEESRDAKRRRIVVDREAVQEALALLDAGTAAQPRVGPAGVVASPKDEPCPCPWRPGDKHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFQ5</accession>
    <name>W3VFQ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFQ5"/>
    <dbReference type="HOGENOM" id="CLU_000288_103_1_1"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000051">
        <property type="entry name" value="F-box and WD-40 domain-containing protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="437"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="643"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="690"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="730"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="816"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1095"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="885"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="951"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="908"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1051"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1223" mass="129910" checksum="F93FB6EF21A643FA" modified="2014-03-19" version="1">MVSFQDPSSSSSSSTTSTSFSQSQTNHLVQQHHLHYHNSADTLAVASSSRHTLDYDQPQSAAASSLPRPRHDLASTPCASTSRRRGSAVSPPSSPAQSPRSDYDDDDHPGSDSLKGSQSLHHSHRSDHPTTTAMATLSVHTPPAVHQPDPMLFARATNSPLQKSIASLRAASPSPPPLAAAPYTQPPVTSSLANVTAGDGWAIIPKSATAQPSATMTMQAPSPATSSATAAQQSAASGLLGLSQAAYASAAADLSNRRCGPADASTNFDVPFGERASPAIISLSQRGARPLSRSGTRPPSPLTLSPAMQSEALNPSGAHRGGLRGSDEDVEIADKDVPMNTDEDSCTSTGATPLVPPATRKLCVRHQRMADEGTTARLQKSIESLPLSDQTAVNTVWSLFSSSSHSRRALILQGILTMCCFSQLSLLSSELALAIRIDPFSLFPREVSLKVLGHLDAISLGRAAQVSRSWKQLADDDLLWRNMCEQHIERKCEKCGWGLPLLSERRRRAPGPAVQLGTPESRDLSSDGSGATSSTTPGTLKRTITAAANAAALEKQSRSRASSPTPSSSSRAHSRSVSGQRDLQMRDRDAPPLKKQRSGLNGEATPCSSTGTVPKTRPWKSVYCERLAIERNWRRGRFTSRTLAGHTDGIMCLQFNENLAHPAFPVVITGSYDRTARIWNLETGEMLRVLEGHTRGVRCLQFDEAKLITGSMDRTLKIWNWRTGALMRTLEGHTEGIVCLHFNEDTLASGSADSNIKIWNFRTGECYTLRGHRDWVNAVTLWTGPAAKKRQQRLREALREGRPAASIKDEDPRAAGTFLFSASDDGSIRLWDLGLRECLLTFEGHVGQVQSLKLVMMDDEAVRKLVGGAAGGAVRKLVGGAAGGVGAEGPQAQRNGASRRGSVHGSGDGDDAPDTVENGDQDMLSLEDQESYFLGDASLSHSRRLSGGLPSAVGAADVGPGSARNAAGRRPSNAAENGERLYGAARRGATGPSPLSSSSTAAAASSSSQQRQQRRRIDKALLRVQERLCEAGLVDPLPLDAEMGDLDPSMRGARNGSGNRSGDESGGQSGRAGDGEANGAGANGERHHAKPRPVLISGSLDNTLKVWDVRTGRCIRTLFGHVEGVWSLDVDKLRIVSASHDRTIKIWDRDTGLCQNTIVGHKGAVTCVSLTDDKIVSGSDDGDIKVWSFAVNAAASAGVTANVPAPLPPVPHSQQAQHDGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG07</accession>
    <name>W3VG07_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG07"/>
    <dbReference type="HOGENOM" id="CLU_322132_0_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="517"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="97252" checksum="C6513DFB8BDDA11A" modified="2014-03-19" version="1">MLRITALSAFSLPRTALLAVPRSRSAPRLAKAYTDSAFSVHVPKAAKPRKRSDRSDRGHVVHRSPARQQPGGTRRPGSNSASGSARKERLLALAPLATDLASLPHTVRTQLDTLQEAIDSQDLASVWAAWERLGANSQHVGRAQHRDILRLSSGLSAGAGHVDQSPQWKNRLGEFANAASMTGDVDLITAWFRLLLAHGQLDAVVGIWQHIVRMRLANATLHEPKLPRTPVTEEQAEEARSFVQLDVSRAGDKIEVHDMVCLVAFACTYSQSPPRVADLFDTVEIGTPFRIFFQSARAKRLHDSLLPHLETATARAADWEAARTTLWDIELARGLSSGSGGPQRIARLLGSLFTLRQVDDVHAIFSTAMRACSQSPPWLLTDDASPAAAATVPAQRARWTESCWSVCLSNFIAAGRIELAMQVWSKFQALKLRPTPRIWNALLDGYGRANNHAAAVQTWTAAVNHASAGASASPPDVQMYTTMINIHLRAKHVEEAMALFADMVAASQRNGGQLTVGAETFNAVLNGLFLNRRHAQAQVLLEDMLAKGPAPNIGTINTFLRAHARLGDLQSVASTIRLADKLRLEPDVVTFTTILDALLRQSGESASTDAVAKTLDIMNSLGVQPNVVTYTAMIKACLVGADAAHTDLASQTLLKDSPDRRAQSSNDVRIEAALELLDRMIDAKVAPSEITYTALINGAMQNPDAVAHAFATKSVPARYRAAPKPLSRLGETVETTKRWTQSSPSVSLALLLLEHMKSRGLPLTSATYRCLIEGLCSASADQAAFFRSMDVIDDMMLRTSPPEPSRALGAFASAALKNSKVRPPMAAPGHTTWIVIFSSLLDRLEYGPRDKVAVETAARALHTAIQLVREMGSLAGADGGLSLSRLVERAASRLAHLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG41</accession>
    <name>W3VG41_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG41"/>
    <dbReference type="HOGENOM" id="CLU_1982508_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="126" mass="13879" checksum="4223467E0FCCACB2" modified="2014-03-19" version="1">MTERYQQACRKRGANPQADADRVSILQRAPPLLARQTCMAADEWPPHAQQSKTGQQSHYPGASCPTHAMTNTPSTFGSRLARIRIPFIPPPSSVPRTTIAALLCTRSAVQSVRAHSSPYMRITRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG57</accession>
    <name>W3VG57_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxd protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000025">
        <property type="protein sequence ID" value="ETS60643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG57"/>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="8"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="372" mass="39922" checksum="453266ABF090F920" modified="2014-03-19" version="1">MAQQNMHAIVSRIFRSPTEKVIAVPEPRADELLVRVHAVGLNPADIKLSALTLSGKVCGCEWAGTVEKAGKEVQGFKQGDRIAGFAPGGQNNRTAAFAEFLCCRADSVFRVPSGTSMEEAASLGVGMVTSMLTLRQFLGYPGAMAQHGDRKGSLASYDGPLLVWSAATAFGMHAVQLAKILSPHRKVIATASAGKHDLLRSLGADFCFDYSDPDVVEKIRKLEPIRAAIDTFGEAATTEKAARCLTVPDQGEAIIVSSQPSMPFAGPKLPRGVRLAAVMSYTASGEPVRVAFALTWPASPEDALEASRMMESLPDWIETRRLRAMPTRDISKSLRRPANVQSVLQCILQDGLPLIAAGKVRGEKLVAVLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG79</accession>
    <name>W3VG79_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG79"/>
    <dbReference type="HOGENOM" id="CLU_1705003_0_0_1"/>
    <dbReference type="OrthoDB" id="10252049at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="154" mass="16886" checksum="006E6149B9469D5E" modified="2014-03-19" version="1">MFNLRLPSFSRLVVAAVLCAMLVVSAFAGLIPNVVSSTEFVAHTKGGLVRAFESDGKWLVEGFEDALDNAVSLRKSSSFGRMLPGHEVTFTPTTSGVTVHNPDSRFHTIRFAGSAQTWLLSPRSKQTFDGITKLQAQRARLFKLKPDAQINYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGA2</accession>
    <name>W3VGA2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_04589</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGA2"/>
    <dbReference type="HOGENOM" id="CLU_559131_0_0_1"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="168"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="268"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="368"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="15"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS60688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="520" mass="56211" checksum="791950675616696C" modified="2014-03-19" version="1">MSHFVPPMFWPRPVHCESASSSEPQQPQQPQQMQAVAVNGNGNGNGNGNGNHGVYWIPHLPGEGRFVVNAKLYSRHDADPSFQEHMEKFRREVAASSPGMLSYKTSVVRGATDKENLICHDLYISDDLEPHPVPSTKEDKEALAAERLKELQEEKREKPVKNALSEIGKSAYNFGLGGIAGSVGATLVYPIDLVKTRMQNQRSAVVGEPLMYKNSIDCVKKVFRNEGARGFYSGLGPQLLGVAPEKAIKLTVNDLVRGHAKDPITGAITLPWELFAGGAAGGCQVIFTNPLEIVKIRLQVAGEIAKQEGGDRVARGAVHIVRQLGLVGLYKGASACLLRDIPFSAIYFPAYAHLKKDTFHEGRDGKKLGFGEMLASAAIAGMPAAFLTTPADVIKTRLQVEARKGQATYKGIVDCATKIMAEEGPKAFFKGSLARVLRSSPQFGATLVAYEYLQKFLPYPFEDTEVADIMRDGVPGEDPSRTHARRALQLLIELHEDFGRPPPAAAAAAATPPAAAAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGC2</accession>
    <name>W3VGC2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">phosphomannomutase</fullName>
            <ecNumber evidence="9">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PaG_05479</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="26">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGC2"/>
    <dbReference type="HOGENOM" id="CLU_009535_2_0_1"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="18 26" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20" id="KW-0464">Manganese</keyword>
    <keyword evidence="23" id="KW-0469">Meiosis</keyword>
    <keyword evidence="13 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="28">
        <location>
            <begin position="363"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="579"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="27">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="663"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="27">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="27">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="27">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="27">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="24">
        <location>
            <position position="854"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="24">
        <location>
            <position position="856"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="854"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="856"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="863"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="968"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="979"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="986"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1024"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1026"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="1067"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="1079"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="1081"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="1084"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="ETS60619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123216" checksum="B78C14DB7CCC181E" modified="2014-03-19" version="1">MVRLTRRTGATPSQSGRHESPPTEPHGETDQLADEMNPTQQQLPPPTFAAKSEADHIKIMLATDNHVGYMERDPVRGQDSIRTFEEILQLAVEHDVDLILLGGDLFHENKPSRSTLHQTMSLLRQYTLGDKPIAVELLSDPNDGAMPGNHFPAVNYEDPNLNVSIPVFSIHGNHDDPQGVGETGALSALDLLSVSGLINYFGRVELPSDDATAGASSAKTARGGAFQEKGIRIKPVLLQKGETRLALYGMGNIKDERMHFELRANRVRMYRPQEDPDSWFNILCVHQNRVAHNPKACVPETMFDDSIHLVVWGHEHEQMIQPQPVTEKRYHITQPGSSVATSLSQGETVEKCVAIIHVEKTDFLIEPVPLQTVRPFVMDDMVLSEELEESGLSSERSDIIKLLRKRVGGLIDRAKREFKERHPQREMPLPLVRLRVEYTNQEISNPQRFGQEFAGKVANPKEVLQFTKRKSLRSGRRGGDGDAANGKSAYVDVEEEGLLAVERLEKVDVGKLVQEYLQAQNLDILNPEGLEGAVLNFVEKDDREAIDSFVTKMLRNTVKGLVTIDPEESRIDGELERLRQHHQQQRQQMEEMDVEDDAPSTRRGARGHESDDSMMDELVEPPVTRTPARARGRAAPRRAEQEDQDDFDEELDDARPAGGGRRIAGSSRVAKAAAPARGSRATTSRTRTSAPAPTFLGQESAYADEQDDSDVGVDESRSTPAPPARGHASVLEMLNQRSTASSTKSKKPAPAAKVSRAKKPAARQMQESIQISDDDDDDDDFVEHHNAAPGDDDDDDFVEPASTSRRTAARPTRRSGRAVTDRIGSTSTETPQAKQAKMSAYSHRKQPRVLCLFDVDGTLSLARQTITPEFKALLAQLRQHCVIGVVGGSDLKKVREQLQISAADFVTEFDYVFAENGLTGFRDGQLLASQSFIGWLGEERYQKLAKFCLKYIANLDLPIMRGTFIEFRNGMINVSPIGRNASIEERIEFEKYDKIHNIRNTFVDALKKEFGDYGLTFSIGGQISFDVFPHGWDKTYALRNVAIDDGKADGSTTAKQLGWDEIHFFGDKTYKGGNDNEIFEDPRTIGHTVTDPQDTMKQLRQLFGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGH7</accession>
    <name>W3VGH7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGH7"/>
    <dbReference type="HOGENOM" id="CLU_055737_1_0_1"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="152"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="277" mass="30097" checksum="6F4E82CA63EFF976" modified="2014-03-19" version="1">MAALRSLSRVADHALTFPPPTRPLCDQLQPTTFDAFPTFGQTAGLAAKPSMALTRSFQTSTIQAVPKVAAASAQGAGPSKPAARRSISSSAPASNAGPDGPVPLMSVANRGSNQLSLETPKNGVEYVLSSMDKMANWARQSSFWPMTFGLACCAVEMMHVATARYDQDRLGVVFRASPRQSDCMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDLYVPGCPPTAEALLYGFLQLHRKIRRNRKTTLWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGK4</accession>
    <name>W3VGK4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGK4"/>
    <dbReference type="HOGENOM" id="CLU_010811_3_0_1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="152"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="573" mass="63050" checksum="06D46834749C3FBE" modified="2014-03-19" version="1">MPNPYGAGSSSISPPSSSSTSFAATPSTQHDRLLARPNAGPSGAAKYQLAPNATTEEEDDYLHEIDTKWDSSSHGWNLRGFLNILTLTLLALGLIMLFLGYPVLIKVKNMYDNDTKGAFGIGGTNGSGQVPALDIVSLVDADTPQSALKWSSSYDQASYHLVFSDEFEKDGRTFWPGDDPFWEAVDLWYSGTGDYEWYSPEAVNTTGGALVIALEEHQLHNKNFRSGMVQSWNKFCFQGGYIEFSVRLPGAPSTSGYWPAVWLMGNLGRPGYLASTEGTWPYSYQSCDTGILPNQTWVNGTGPDLAIHSSGTYAYNGELSYLPGMRYSSCTCPGQDHPGPNNNVARSAPEIDIFEVQVQYKDGARHSYASQSLQVAPFDDAYGWGNSSADAKIYDDTLTEFNTYTGGQIQEAVSSVTRVPDRGFQLTQNEYVTYGVEFSPDFNYDGSGSMTWYVDGKPSWTVNPKAFPARANLDIGQRIIPVEPMAIVMNLAISSGFQTVNFGEGGITFPAFMEVDYVRVYQKDGQSDLISCDPADHPTANFISTHQDLYYNNNLTQFPRDKYTWPKNKLQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGZ8</accession>
    <name>W3VGZ8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGZ8"/>
    <dbReference type="HOGENOM" id="CLU_016426_0_0_1"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="864" mass="94498" checksum="BBFE1038346D3675" modified="2014-03-19" version="1">MSVRSAKGMASASARLSRPLSTTSNAASLSKRLRSHWGSATASNTASASPAQTESTSASSPSGSSTPSSQSSTASASSAKAPPRKAAFRALRHASNSTRANAPRKFVASYDKGKAKEQGGTQSAADHSASMLKELNALDDLLDSLQSKAFSISQRLKAVDLSRSSSKDQVEEAWGADRLAPPNAESTWSAGPAGSDASSKPSDKKVGEPTTRLVFGDSLLAESSLRWRDSKGKTVEGVTYSGPFADEIKRYTESITGCVTANNVPVDKVAPLREMEVAKLAHGLDRVLFNPGVYWLRDPRSGIYNFDPRIKDILDVDLFDYAALPPYITSSKDPELAKLTKQHAKKYCGSTSSMTSLLSQCYFLISGWRNPDTSGFSAPFAGLPSGFSVGAKLPASILLNYKDGFYAIDADKASAGEAENNNYVLTSLGKSMEKMLTATPDEYAKYQRINSWKLSEEERTKPEAYHYACTGNMMMRSQLDCHDERLPHKTFDLKTRASIGIRNDRANYVEGSGYQIRRAQGLLESFEREYFDMVRAAFLKYNFQVRIGHMDGIFVAYHTTSTIFGFQYISVDEMNERLFGSQDMADQAFKLSLGMMEAVLDAATSMFPEQTLKITIEAKDKSDTGMVVYVEPADQATATESNAANQASAEEGAKAGGGGRSIVQLDITVDRYLDGGLVLGPVDFSFLPGRRVDPMNEDEIERRLRQSLPPVRWEVDYRISPRSDLTEAKIRANLQAVRDRQASLGSLILPNVEALNEREQFRTTELAKNPEALKRFLEERASGVAAGMPLAPGQRSAEAASNEAVPQDALVAADKSPRRKQAETRFIRMRNIRTLRLRELAKLGAKDATLQKSTDKHILYQPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH16</accession>
    <name>W3VH16_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH16"/>
    <dbReference type="HOGENOM" id="CLU_453397_0_0_1"/>
    <dbReference type="OrthoDB" id="10409513at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834150" evidence="2">
        <location>
            <begin position="26"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="625" mass="71564" checksum="C0CF5A057DAC3D36" modified="2014-03-19" version="1">MTSQLFVCFLLWLRFVTLLIGTVSCVGGSDRSHHHRGDSSSSAPDAQEQTDSYSFPKRFAFTDPMSGRPMTESYYDHIAQLASAQIDKTNYYSHSWRSIRSGGDNQIKSAAPTSLPSDLSKNPRYLEYSVGDSHVPTVFIKVADEMPHNPMGAYNPDIIVYMHVIRVWRDTDAKYQLEPKLVLRGRPQDASSSTRRPPPYRVIWEREHAYRRGWEWINDLPRVFASKSLGNIERLGYIPSTIERQVALLPHESDSSRYSSYSTDEMVDLLEQSREYMAQFAPIEKQDALMWYGLMTARIDRDRQHTPWFQAPIFKNFDLAGGQMQLETYISNGETPPVLDRVMYALSPTRNRLVPRAVVRPVQVMPEVRFETIFKIPTSLQELSSIDLAYTPQLARPQRTQAEKYRPLRLMMDRPRPIGHPLDLFPPGHLSRSAMDRSNRAASAESSRRGGRERAEASTDRPPRPPLPPSLKDEVSDLKREKEEELVSRQRMHLSSDDAQRASGNIVGPGEEPESFLPSSPELVHDIEMPQSAILRHMEPIQSQAGGAQALHNDHRQFLPPRLEHRLVPQPAQPRQQVRLRRPRYDGPNPYEAPQENAIDVLMAHLNPHVEDAWRYGDAWRYGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH25</accession>
    <name>W3VH25_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_261457_0_0_1"/>
    <dbReference type="OrthoDB" id="2556503at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1465"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1512"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1550" mass="165723" checksum="B8437E65152623C8" modified="2014-03-19" version="1">MDADRAAKARKHPQTAANFFVGTNSRVPRMTLAQTTHIIPLPAPPTPGLAPRSGFVAARLRASPFPSSPSPFTPTTPPRSAAKAGAKVSKAIEHFSRPSPLPGSSTSTPFPPGSEVPEQRPAGSKTLTPTKSKAAVGRADSDAYIRNKPDIPTTSRHHMQPLPSSERVGYPQPRWKGPDSRPGLSETANATSKSAASVGDVKGRSANLGTGTTALPDAGHNDEVSAALAQSPDPSLNPRSTLVASTSKQLDQNQRFGHHSTVTPSSQQMPASADDTQDTLAQNKPPANQSIGKLDDAVGAALVPLTVPSNIEAGELPLTSVQRDAQASTSSAALFPFEDNNSVDDLLEAGYLDLFSLPSSSAESSGASARPEGVAEASTSMSPYKKPPANKSLDGNIGDRADTRVGDQELVSGRTVESSCVTSSSKSQWLSRSGGVLFDVGSESSARRRPAGGPVSQSRIEGQRAGTVLEQDGSGYWSVPHPYNSSEALAPPEDDSSRAEADERPQAIKGSSIGLATPSIASRPQSLSQLETRPVPKELPAIGFTAIDGPESSPVQKDRFAIVDSYADLGLVDQSEYGALSQHARSPTRSDTLALGGSSKQEEQPNHPKELSLLSSPLRHCGDGFVRLNQEVDPSGNQRLDQETRPLRSPSQPSSDSFVPSHDPDRRTASQAISSASEDDVKDVPGETAADANSTGNRRAADSDPEAAAVVPAVGKEAAPVRLQLDAHAELDADDVDEEDDSERQLAFERIASWVRETAEDLEHDNTGEFQSHDRLEAPVISARRKTRASLPHCDAPDLLLDLSGLLASAEPDELSPSPSTNFSKGSSNPKRILAKTADVSEGLRDQALTTEEEGRALPGIQSESSFVPQLQRSFSHRSQSQKDPSKPPRKVPGRLHIPSPHQNVDVKVRRQSLELLATRKARAKSPKHEPAALDPSSPGPPRKRSSHFDNALRTWSHPADDEGQSPVRHDRQGDHVGRMAKLWDDTGQSSEEEEVASVTVCKRMTLRRMSGFTVHSTPRHETPPLPLPGKLLRQTGEAFNPQVAVEQVDAGLRSSLVSAWHQVDAGPSRVQSQARRSDVATKRTAAQPKPTSPDEDMGLASPRLLGEPQTTPTGFKPQATGADFAAESIEVLRPGNSVTGSAVDGHGALLKPTTASHRVLKQLQLPNTRTKLDSSIRSDVRGSDSTPYTSFSERSTPNTSRAAASALTDETRISDLASSHPPSSSGKAAVRAHGNVAQSRTASKPTLLGSQLKTRQFGREHRLDPGHHTSLHAEHRRQYERGPVHLGREEPLTSAHRHEHHMDEDDYPADSARFSERQGCTGAHRCTCRHDRHFDHRSQAFPAFEISFQMQEPKMAPHCSPGSMFEFGLRVLIKPCGDDDAANATWRVRPPSGLEVHPGADAGGRSTARAGAGALRYEHSDLTPCEMRRVQHEAQEQLVHTLTSPPRRPADSVDLGVGETECGLSSPFLSPGTNRASTSTSARPPLRKMMLGSSRAASITTSRDADDASRSLRTPATSVSRRVAPVLASPLPYVKRAPRTAVASSRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHA3</accession>
    <name>W3VHA3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHA3"/>
    <dbReference type="HOGENOM" id="CLU_674595_0_0_1"/>
    <dbReference type="OrthoDB" id="3362298at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="408" mass="44499" checksum="27D3447CBDA5E34E" modified="2014-03-19" version="1">MPIGCATPQPHWSACNIDGAHKFLLQRLCGGSEASLRWACRTTTAPAASHTARLHCRGQPRSAPAQLSDRPTDPGRPFVDRLSYTPIPDIARHAHHPSHPPSSIPLLHPSRSFIPATPATFRSDSPTLPKALDSTAASARCPHKNAPRVKQRTSVMSGKFRLHPEPGTERHAPFRLGSAIYNTIRTGGLGSGLLVPHVLLPIYGIYVVTHRSGYWTPEFERGLTFAIALLQGVSFGSAIALSIVRYSASGKAIKGRRIEKTATDSEESSQHRIEVALRASIYLFVATMLWEYLVHSKFSPITDEQARHTSSGFLTATGPLRRFLSNESILPQPDEVRDQVSGLGLNLEGKANDLHNAIKNSPRIHVPGTQAPPKSLFLRAYQKVWYSVTGGPSGLNLGLFEIGPNIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHN5</accession>
    <name>W3VHN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05852</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHN5"/>
    <dbReference type="HOGENOM" id="CLU_012062_21_2_1"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000895">
        <property type="entry name" value="Hsh49p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="150"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="319" mass="34911" checksum="254F865FA542B979" modified="2014-03-19" version="1">MLCRPLQHHAIFASPTPALVAEKRGSCWTILLRPGTLPDHVYLPHHKLGDMSRPPELDRNQDATCYIGNLDERATDAIVWELMIQAGPLVNLHLPKDRISQTHQGYAFAEFQTEQDADYACKVMNGLKLYGKPIRVNKASNDRKQIDIGANLFVGSLDPAVDEHLLYETFSTFGTIVGLPKVARDPATGEPKGYAFVSFDSFEAADAAVEALNGQFLLNKNITVDYAIKKDSKNGERHGTAAERLLAAQARKNNALPTQQYPPAPHALPQPYAQPPQSNGAPPPAWNAYPQGAPAQQPGAYAPPINMNPAPPAYPHYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHQ4</accession>
    <name>W3VHQ4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHQ4"/>
    <dbReference type="HOGENOM" id="CLU_294767_0_0_1"/>
    <dbReference type="OrthoDB" id="2551638at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="933" mass="98736" checksum="FA1C12470C008D7A" modified="2014-03-19" version="1">MRRPAPPPTGDVLDLDYGSADGTPLESSQGDVTNETNDHAPGADEVKSSHALTHAKPDELVRSTRKLPAAYDTDDADPACSTGPPSLGPFSTAAISEGFQVPEHNQDANAAAGPSSARLAGASAAGDNGAAAETRLWVDPAQHHPPPPTYPPPALPHGDVAQEQQQLPSHYGYDPNLPHLHHSAFEPNHQGLHGSVYFAASAQHPIANGGSDYSQMTHPFVPNDQPYDPRMPMPFGPFAAGSIPPQYAFPPYPQSNPYPGGYAGHLMDPNAMDDSTAQLNRKQRKKLLKNQKKKDKKLRALSATAAPFDPASANVELVWTEDGKPQALAMISELHSRGVPPARLAEQGVPLAMIEVCCAELGVSAQGAGQPEQPAEPPATAPSDSESQGAKEVVQTTKAENELLQKQEQGVPLTPLEELRRKALASRLAKAAAASRALAQEGANAESNGSVPSSADISSKKSTAFDRVATSGEADALVSQISGVLRGLLQPAQPTAEQSSTSRKRAYRDIDAVDPSDSTWDGDLSAPDAATSALPARRQRISYADNFSRAAVAPSGEVDLSTPLPELPDTANLPQPRRQRPVAADFDTAEYVPKPPNRFLDVPSGLNTVVDLSDEEPDDAEMAAFDSADGWTEVRPALDPRRVLELRHRTATEHYDVFCSLNGLSPSRRPATPHRDSGGFEIEVGAVPETLVAQIAASGTSSGGPSTPSREDLLRKELEIKQLMRKIQMMEERKKQQEAATAPPRSPAQRSGAPEEEDGAGLRPGGANGSQSAVQPADESDSTAAVKEASSQSGSTASSSVRLDPALQKQRQQLLALLASRRKNASAAVPRDAASTSEAAKDGGVPAPATGMAVSDAGLERKEEVRGSRYVPLVPSLFSSVASRVRAYLPLSWGAPCGDADRLAIRWCPREADGADCTDTRCTQRHAKEFNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHX7</accession>
    <name>W3VHX7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05135</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHX7"/>
    <dbReference type="HOGENOM" id="CLU_022477_0_2_1"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="213"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="662" mass="72411" checksum="CD04FFE63458C1C1" modified="2014-03-19" version="1">MDGSGRILTIDRWLDRSRKKRALCKHFDLTPWASTDLVELDHGLPRPRLRRTALTRWFGTKIQSFEQVYPQAGLGCRSRSVRDAVDHAVNFKTKVIADWSSRPTPPLFPQIRTVPAAARPPKALAVSKRPSSLRTVAGTLISIGTSTTDASIRLPHQPSSSNYNSSHRTDASRLARTLPSLTAITIPRTFATSASKMSVAVPTDFNKVLYQSLAEADPEVQQIIENETYRQFSGLELIASENLTSLATMEANGSILTNKYSEGLPGARYYGGNEYIDQLEVLCQQRALKAFNLDPKVWGVNVQPYSGSTANFATFTALLQPQDRIMGLGLPSGGHLTHGYYTAKKKISASSIYFQSFPYNVDPATGYINYDELKKNADLFKPRMVICGGSAYPRDWDYAKLAEIAKTQSAYLMADIAHISGLVAAQVQNNPFEYCDIVTTTTHKTLRGPRAGMIFFRKDRDAEIEGRVNAAVFPACQGGPHNNTIAGIAVALKQAAEPAFKEYAVQVIKNSQAIAKVLSGKGYKLQTDGSENHLILWDLRPLGLTGSKVENICDLAHITLNKNAVSGDTSALVPGGVRIGTGALTSRSMNESDMEKVAEFLDRVVQISLDIQKTSGKKLVDFMNAARQSDAVKQLNKDVEAFATSFPLPGVPDTSVIKKPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI54</accession>
    <name>W3VI54_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_05618</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI54"/>
    <dbReference type="HOGENOM" id="CLU_036590_6_0_1"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="14">
        <location>
            <begin position="30"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="251" mass="27187" checksum="83E4E51243AD8CBC" modified="2014-03-19" version="1">MQGSHEVEEQATAFLDRHLRFSSGSKAERPHVTLTFAVSHDGKIAGPGKAQLALSGAESMLMTHTLRTLHDGILVGIGTVLNDNPQLNARLLSQPPTVAQLPKPVVLDSQLRTPSDCKLIRNHTAGVGRQPLILASERASQQRRLELERAGAEVVQVPSLDWQTILKHVHAAGLRRLMVEGGAAVIDSLVQQPQHIDALLVTIAPVTVGPQGFGFSSPLPDVDTTDEQAGWSPPSRSKFGKDDVVVWHRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI68</accession>
    <name>W3VI68_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI68"/>
    <dbReference type="HOGENOM" id="CLU_1421965_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="191" mass="20763" checksum="74A707D4F2F6B2E4" modified="2014-03-19" version="1">MADTIRRLIQRSHPTCIPISNLVCENLLPSRRLALSPSSSSQQRSQTLSPPPPPIRVLPPFSVRRWPAHSHTLGVFRPAFRRFDARLPSARLRLTTPVSACSAPAHPSASAAAVSPPPARSLAPQPCLQPQYDKPVASIHFSRLSLSRPTDAQHTPPRASSPASAHNKQRSACCFPPGQRLYLDGPLSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIC4</accession>
    <name>W3VIC4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIC4"/>
    <dbReference type="HOGENOM" id="CLU_082438_3_1_1"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="8">
        <location>
            <begin position="49"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="135" mass="14790" checksum="8340A7157BF24DA6" modified="2014-03-19" version="1">MPASFKRYVEVGRVVLVEEGPSAGQLAVIVEVIDHNRAIIDSPTTGVSRQAFPFKHLTLTKLSVPGLPRGAGSTAVKKFFDKAGVAEKWSQSGWAKKRAAVKTRRSLSDFDRFNVMLLKKQRRNVLSPAVKKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIH1</accession>
    <name>W3VIH1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_05389</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIH1"/>
    <dbReference type="HOGENOM" id="CLU_006714_3_1_1"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="40"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="520"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS60541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="734" mass="77625" checksum="ECDA5E7C7E027B21" modified="2014-03-19" version="1">MRAANMLRLGATRLSTPLLRRGLATHAAVNPASGTYNLVEKIVQKYAVDQAPGSHVKSGDYVSIRPGTVMTHDNTGPVISKFGSIGATSIYNPDQVVFALDHDVQNKSAKNLEKYSKIESFARKHGIDFYPAGRGIGHQVLVEEGYAFPQTLAVASDSHSNMYGGVGCLGTPIVRTDAAAIWATGQTWWQIPEVVKVELKGQLPQGVTGKDVIVALCGYFNQDQVLNAAIEFHGSGLSALSIEERLAIANMTTEWGALAGLFPTDDVTLGWYEKQIRKRDKLEFQIGSSPSPSGSHPRLNMHRLDELSRTLLRPDADALYSKHLTLDLATLVPHVSGPNSVKVSTPLDELAHQNIAINKAYLVSCVNSRASDLKAAADVIRGKKVAKGVEFYVAAASSVVQREAEEAGDWGALMAAGAKPLPAGCGPCIGLGVGLLEDGEVGISATNRNYKGRMGSPNAQAYLASPAVVAASAIEGKICGPSDLDPSLLPPSRGLKYSISTSADAASAASSSASTDAAGVEVLPSFPKSFSGPLIFAPQDNLNTDGIYPGKYTYQDDITPDKQAEVVMENYDATFASTVASLRSNSSAAESDGVKLGPVLLGGYNFGTGSSREQAATALKYAGVPLVLAGSFGDIFKRNAINNGLICLESHELVQDLTALYLGSKDAVRNQKAILLDQSNVQINSATGEINLSYTAPDGSKVNKKYIAKPAGIGKSVQEIYTAGGLEKWVKERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIJ9</accession>
    <name>W3VIJ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000511_4_1_1"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="45"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="8">
        <location>
            <begin position="754"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="7">
        <location>
            <begin position="1146"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1067"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1454"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1166"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1479"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1494"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1591"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1640"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1694"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1713"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1836"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1856"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1890"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1928"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1974"/>
            <end position="1987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1996" mass="219185" checksum="20418566173F2569" modified="2014-03-19" version="1">MPGAASSVIPSTASQLTQPVPVTSARRIARCSLGMPPYPFSSLNPRSQQALHDALERSNADHDDLSLSSLLLALLRQHCLSSHTPDNAAYQLLAQLHQHATSTESQSIVSDCLLDAIWSFDLELESRNDLAASESAAAQPPSLALHPHHPLPLALARQTLAALVADLLSAAVLAEDHVSERLEHSLLALVGLIPNEVYFNKRSIQLRTARLFKQQKFNLLREENQGYTALITEIVTNLGPPTIAVRHNLDPATQAQPQGSIFAPDSASVIEQESPALRNRRAARVMNNIQALIGYFDLDANRVLDLILDLFATEIIRHYPFFLALLSHSPWANADANPASASSANASATNLFADVNLDLSLDSGDRICAQLLGFKFAHYAHPDTKDATPDELYLLAALLIKIGIVRLVDLYPHLSPSQDGMRSLQTKHRQALAAKASTARANALSMAAPLTDDADPSSKFKDGTKAKDEAPAKDPPNQVVGLVRAMLSLGDLRHALFLLTRYPWLCSAFNEVADPFIRLLNVIVQPAYDEISFSRMNPPCAQPSILSPRPRWDPKSQAATRPAVKSLVLTRKVPEPAPSLSCQHVFFYPHWTDSLPVCRSLDDVLRILVPLLKVLGASLSRDAALFQKVCRLTKVGYRLATTAAAAATSNAQDPYDDFDEPQEDSQSQSWFDLLRFHLLPALSLSPSNSGLVDEVWMLVRIMPYDKRFSLYGQWKYDLYQLPELRAAQAATEKEAKGILKRISKDNIKQSGRNLAKASHSNPTIFFTVALNQIQAYDNLIQPLVESAKYLSQFEYDIFAFNLVDALSNPEKERTKQDGTNISLWLKSLAAFCGTLYRRYAMMDCTPVLQYLVNQLKANNSKDLVIMSELITKMSGIEPLANLADAQIAALTGGRHLHMEAMMAANALTGSKERLAFRRSGQRLLHALVESKLSVPLLILVAQQRQACIHLVPESEAHLKYLGNLYDSCQEVLLQYVEFLFNHLDTAEYASLVPSLQHLCVRFGIEPAIAFYIARPKLVHSMKQTEAADAAERLRAELTASRAKTKAAEDDKAPAQADAAYVLEETAEAADKANAADQDGDVDMEEAAAPSPTKDAAGDKTEVDAVNKELPDSKLPSPAPIEPWHRGLIDAIHAAKDMLPESALPGLGVHFYVTFWQLSLADISVPIERYQQEVKRLNAVIRETAAEDQRKRLQDNVGQLNAEMKDQMKSHEVTRKRLQAEKNHWFVDAADRGAIVAQLIQYCLFPRALLSPTDAIFAGKFVRTVHNLGTRNFSSLTAYDKIFVDHVAAIIFSSTENEARNYSRFLYTVLADLSPWHRQADIYAKEAIGQKLPGFQMRWQDRHGGEEIPKADLLTWDQFRLIFCKWQDCLQRAFKTCLSSKEYMRTRNSIIVMTRISPFYPLIDSHGTEISAIVESLAANEQRGDLKILAQGLLATLKARAKSWLPLHQARKVANPPAPAAATETADDSKAAPTSASAKVDGDERKQQDKAAPTSAGNDAKSSVRAQRDPAPPASTNINGRSSDRASEKTPAPSAAGSRLTAPPTAPGGRGNTATKVPPSANLPSRPGGAPQKAAALESKDRRGGAASSQADGRRGEDRGNARQEDASRRGGGERTQGTVPAGPRNDASRDNGLPSRPSREPNSADSRSRGGASNSDRATTAQASRDTADAKGGVDAMNPPTGPASTTSAQAVRNRAERDRNERSSSASLPAPNKDKDTRDRNDRQGDRDKTRNAERDRERERERERERDRDRRDRDRSARDRDREREKDRERERELALRDRERARDRDRGGNARDRDDRKRSGGRSGQPSRNATPVRDLPDGGGGRESGSTTPLGPRRDREREQAQRPRDRDRESAAATPTSARSTPGVGAPEEISIRGGAKRNLVDRLGGASPRGASPAARAGKPDAADPASGWDTPNDASGWDTDEPAKRIKIDRNQKYAPAGPPSAPAAESQRNDRRPQSSNSNRNSFGGGRDRRDGGRDQRRDRSARRAGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIL7</accession>
    <name>W3VIL7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04401</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIL7"/>
    <dbReference type="HOGENOM" id="CLU_000288_84_3_1"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="371"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="657"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="218"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="745" mass="80264" checksum="8219F85260BC28CC" modified="2014-03-19" version="1">MPSIVASSAMNSISTTPVHDTGSAYATPPNQSTSSFASGSNTPSHAARMQSSGIGESPAPYSSRPYHSSSTPHQSNGGTKDKKWKQMFKFGSIGRKASGSTTPNHGAHDRSWHTDSTESGNNRNQDYFEHHQIAGSSSFQPMNGSTVVTDPSSFSNDSYSSEDRNASGSIGDAMVASASGKLQPPADISDNEANHQGFASRLMRRVSSAPDANKLFKNGQHASAKGGDAAASTKNGYLSPDASGAQHGQFASEGGAANTDSSNPTYFTNSPVRMDSNATSFSYKDFEKGRSVSAKGSSTPKSGRIAFPGSGRSKSSNGKDKKSQLPPPSSSANLAALAGSTGVNRGPGSFRRTYSSNSIKVKEVEVGPNSFSKVKMLGKGDVGKVYLVREKKTDKLFAMKVLSKKEMIKRNKIKRVMAEQEILAASNHPFIVTLYHSFQSEDYLYLCMEYCMGGEFFRALQTRPGKCLPEEDAKFYAAEVIAALEYLHLMGFIYRDLKPENILLHQSGHVMLSDFDLSARATQRGGAPAMIRQATPGSAPLVDTRSCIADLRTNSFVGTEEYIAPEVIKGCGHTSAVDWWTLGILIYEMIFATTPFKGSTRNETFSNVLRNEVQFPDSTPISSFGKSLIRKLLIKDELKRMGSQSGASEVKQHKWFSNISWGLLRNSTPPIVPAYSNGVDAVNFRNVRESRSLNLDDQGNETKAAKPAVIKAVAGQKNVGDEEGDAVVSNPFSGFSSVTLKHDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIT7</accession>
    <name>W3VIT7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIT7"/>
    <dbReference type="HOGENOM" id="CLU_321080_0_0_1"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="6">
        <location>
            <begin position="410"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="903" mass="97565" checksum="6AD4966B5F6A4A05" modified="2014-03-19" version="1">MALPLHDGSLVGDGSQIGMFPVLADQHLEKQARLLRSAANPRMDLVLLVLKDAVAASASATPAPPPGMSAAQFALVQRMLAARQRGANAASAQGGGAMEPKRGPQINLVLWRMGDDSTIVWSSPLSLEKLMDPSPASPLQEHEDLLLHDIVWSPTGDRLALLATLTRSPLASSSTAKPRTSTFLRTYSVQDGTLLSTVQLHLAHASSAPMSIQWLDAEFAADGDAVDGSAEALLAKLPPLPQLPPADTFASTSATGNLMPHQLRMMQMAGKKPPPSFQYPSQLALQGRGPLSAIPALARSNADLGLLDGADGSLALNPQSALPLTPQTVVVVAQPAADNVHLVLDGQVCIGSVPLASPSDQQPQSQLVSLSRDMSRLEVLSTSFRAALTHVQISLPLRATTRYAPSCTRRRIAAVSRASHLARFYLGYALDTASALQQLYQKEYVQKVTSEWAKNIDDISSKFGGDMKYELINVLLTGRAGPAAEQFLLGNLTEGVLTRLEQHTHAAMYALKKHVADSLRPSLERAIICIDGLRAYTRFFDRPDGETEQTLAKVLEMLQRVLAAALQLADELDQEALVSQEFYRWCRTERDRQERIKQDQDEPRLPIVYDVHYVAKYIDRGFENDAIAQTLGNNVAQDATRPVEHELHAPSLAEALEQAKLFLSDPHTASIESESNTSGEVQTVAIVPMLTTAITMLGEQMAQLLDADLQKPLLHSNSNSVASQASALVMEDVPATSFASIVEQQPERIRTASFLSTETMLAAFIVRCDDTSSIFVVRRDLSADAGILTAHFSIAQLPGQGSVDIVDVGFYGDTDLLVLASLEATSVLLAFALPHLPFSAQASEMQQIAPTRATEFEPGFRASSIAVNTNKQTVALSAQDGTRIVYLDMATVEPYDTRMHEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJE4</accession>
    <name>W3VJE4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJE4"/>
    <dbReference type="HOGENOM" id="CLU_1215224_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="228" mass="24210" checksum="E4873BD1BE0CD30F" modified="2014-03-19" version="1">MTDCLTEWASAQPGSAGLYWQAAYSTAQTERTERERDRSLLAGLARLGSPLAVARPRADLSTPASPGRPGLRAVSLAVVHPLRPPRSPRLLASRRASLFASSTTTNTSLIPHHHHPSALAETRLVVLLPHRAHPHRALLFAASRPSRSILAVSSTHRTQGISLILLAASLPDRLLCASIRSSLLPQGTSPCSEKKLRIYVAASASASASAAQQIYSGLVSVTSSVRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJJ0</accession>
    <name>W3VJJ0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04212</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJJ0"/>
    <dbReference type="HOGENOM" id="CLU_051314_0_0_1"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="338" mass="36153" checksum="81B17643E676AB2B" modified="2014-03-19" version="1">MLGSVGLRFACTRAAPAWRPALPLARPVLCLLSTRTLSMHTSLPPRSATQRGISSSAVHLLGTSRASTLGRSVNLRGFASTSSRNDSASPPPSPPSGTNQDKAKPALSEDLLTLPNVLTMLRLALTPYIGYLVATHQFAPACVLLFVASITDVLDGWLARRTGKYTVFGSIADPAADKALVTTMVVSLALSGMLPWPIATVILGRDVALVASAFVIRYRTLQPPKTLQRYFNPRLPSASVTPTQISKYNTFLQLLLLGILTMYPLLYPNSPPPPLVPTKQEDDSTKRLVDRAVAALMWITAATTVWSGLGYIGGAGARKVLAQRAPSLLARNKPPPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJS1</accession>
    <name>W3VJS1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227207_0_0_1"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491">
        <property type="entry name" value="A-TYPE INCLUSION PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34491:SF74">
        <property type="entry name" value="DUF4456 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <dbReference type="ARBA" id="ARBA00022448"/>
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            <dbReference type="SAM" id="Coils"/>
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            <dbReference type="Pfam" id="PF16755"/>
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            <dbReference type="EMBL" id="ETS61062.1"/>
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    <sequence length="2654" mass="267054" checksum="18F248F1773F92C2" modified="2014-03-19" version="1">MSSLTYSETDASEAEAKHLVLRQIAKDVTVRLSEPLRVAESKQHTNLLAVSDVNGLVFAATNTGFSVIRTSDLRSFFAAAARNTSPAFDKSLRFIDTVAAACIASLPTFIRSADNHATVLVGFQNGIIAAWAVTGLVEGAKLDPLFVLQPPSPNLPLIDLVPNPSDRPELAVALYRQDGTPGVESGTPIMVDVRSGSFGAQLSATGSRATAVCWSVKGKQIAVGLESGEIVQVTPEGEPKDRIAKPESLPGQYFISDLRWLENHVFIATYNLPSSGSPDDDPEHSYEVYTVLRDAKAGKITFAKMPMDPAPPYGDTARSGTRYAAWLKAWDPSKHLVFVASGPSTDVGLISCSATESGPAAWATVELEETSKPILPFSSVDQSSDTAPVAIDFDLTSADEVDDPNAVARGDGNTKLPSVPILYVYTSDGVLLAYNVINTQGPFHGMVTPSAIPVAQSSSQAPAASASATNTAASAATPAAAPATQPSTPASAFGSASPFGQPSAFGQSSAFGAKPAFGSTTSAFGQSSAFGQSSAFASSSPSPSTGSSAFGAPSKPSSGFGFGAFSGGAGSGKPTSAFGSTGFGFGSDQSTNKDSSAPPTKSATSTPASTAPAPVSAFGAKPAASAFGTAAASPAQPSTPSTPASAFGSTSAFGSTSAFGQTPAKPAFGQSAGFGSTSAFGTAPAFGSTTSPFASAKASTPSQASPGSAFGAFSTPSAAKDASSTSVGSGFGGFAAKAPSAFGSTSSPSAGSVFGSGGKLETKSEGTSGSLFGSSASTAPKPTAAPPSAFGSTTSAFGQGSFSAFAANKQAEDKGAKSKGADASDTGSKDSGSFSFGGMGDMFSSNDSAQSSKKESVQTSKKDAGALTPDSGVNSTVQTPKSETAAKPFSFNPSGTFGSNSAAASPSKDAQAAKATSPPPPAPAFSSLQPGFNASATFGSQPFSFGNHKASANASAPPTTSGSTATATTQADVEGKNGEAQKKESQPAQPSPSATQTPTQEAQASSSKAATEVPKPTFSFAPASKAPALSTSSQQGEPQSKPAAAEPSKPASAFSFGNSPAPSQAAPAAKQTGFGGFGTPPTSTSGQAKDAPAFSFANLDKPSPAPTSTPTTQPEASKPSAAQSPLSFGGPGSLPASTPAKSTPATTGASGGSFLGFNSSAPRSSSPLTSAPLNSSDETPAGSPEKPAATASKPFSFQQDKPKSAQAGFGFGSGAGSPSPFSPTPTPFSGFGQPKAEKPEAAKAEAPAKLSAPFGSALAPSFGGFGSSAKPAVSPAPGPAPTPATKAAPPAPADKPADVRSGSPLVAGRAPQLSSSTNAQPAKVAESGIQGEFLKAYLVLTQELEVLRSNVEQCASFLADLREPTPLQHSVEDFGDNTKWSFGDLPKMLALAKSMRPLTERVENEAAGHKRAVAELQSMQLKAEAKREEVARFIRARSDPEFAKMIRIRQLGPEHVENQTKLRKASQIVQSRIAELEEYLAALKDRIQAAKTGRATLKAPSLDSIARACRNITARTTAVTLQLDNLALEMDLMRPAEGDTERDLRRSESRAVSVLSGIQDGAALGDVSSLVRTLPAATAVRSVDQIARAEQVKSESVDVFVNARKIPVLNKRAVPTTQQVGRKTTTPMQGSDLQIAFAKGPVHLGRRPPAPTPAAVPAQIEKPPSTPRADQYASAGKNVPVPVLSKPPAPATSTPPARPAGSPAPPATSTAAAAPGASAPATSAFPASAAKTDGTPTPFTLAGFGTPANAAPKPASTPFAGFGKTASSAAPAASEAAGSKQPSTPLKFAGFGTPPPTHAAAEKPPAASAPLSFGGFGTPPVSQGAGQKPPAASALPSFGGFGTSPATQGAAEKPPAASAPLSLSGFGKPPVSQGEGQDKPAASAPSSFGGFGTPAASPAKPTPAPFAGFGRPAAAETTDKPAFGSGAPLNFGKLSSVPAGMFDLPAQEDTPFQPGARAPSSSPSSIRASHSSKPKSRGSAVQLPPSEGTQASKDVAGAAKAASDFFALPLQAKTEEKSADKPAFKGFGSFGSEPGEDKQAPAAKPSFSFGDFGKKTENAQSAPPSTDAPKPAATGFSFVDLGKKTDKPEAAKADDAAPAKPAAGAFSFGDVGKKVESSQSAPSASEPAKPAFTGFSFSDSGKKTENAQDRKPDAAPAKPAFSGFSLNLDKKAEDAGDVKKDPASPKPASTGFSFGSAGKSTGSTQDAKSDSALAKSTAGFSFGHASKKGDAAAKPYAEAAKPATGGFSFGGLGKKTGDSASEGRSPTASGFSFGDAGKAADKETATSSTPATTASEAPAPKPASTGFSFAPAAAKTPAREETKPAADAKDAESKVKAESNPSNFSFCKPTEPRNTQPLTAPKEPEPAKSPADKDSAKKDTEKAATSESGAASSKEAEPAKTGATTSTVPAFSFAPSKLNPSASAVSAFAFKPSGSSFGSGAFSKPSDAGVKTAAAFSFVPQPTASPGSAFGSVSSFGMASSSPSTPTARDEGTPKSAFSMSGSGFGAFATGNRTSRFAAATPAKSKQEDEVDKEATPSGAGNSLLARMSAAAPDEEDEEDEEDEEDYDDDDDDEEDYDDEEEEEEGDETGSLEESGVRVEKPDDSQRSDDEPEAEDDGSEDEDEDEEDEEEGLSAVEEEPEEEEKQAAAQDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJY7</accession>
    <name>W3VJY7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Patatin-like phospholipase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJY7"/>
    <dbReference type="HOGENOM" id="CLU_009031_2_1_1"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="390"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="169"/>
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    </feature>
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        <location>
            <begin position="730"/>
            <end position="795"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="825"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="935"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="421"/>
            <end position="425"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
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        <location>
            <begin position="764"/>
            <end position="781"/>
        </location>
    </feature>
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        <location>
            <begin position="861"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="972" mass="106818" checksum="08431D84D2D3C21D" modified="2014-03-19" version="1">MSSIFQRRKQPDPASLSASNDNPIAKAANGTTPSASHRNQAQSTDVQPSTLRTATKRRRSLGNILSPTLFPRSPDEEDLDPLLTADYVESEHIEAFREALAQDLGQQEYQPTSSSQITGSSSWNVFGYGKTPKSPSPADNVPAPAAAAALAEPKSPAMAEPSGTRASNPRKVGRIAAASDFAPINQKISRKSKQKKGGIVDSGVREGFVFHTLRWPLLIFIFIVISLEFLLYVLVRQLVNLIEYSIAWRGQKGQLRKRMRGATDYAQWKEAALAQDDFLGYERWKTEDGSGFYDWILVKKVKSSLKNFRDKDDAENLLGVLDLCLRNNFAGTENFRLYSETYLGTKYLVESYLAEIETALEYIQQTDKIPLDTKRSFYRAVSKNLGRSALCLSGGASFGYYHIGVVRALLDANLLPKVVTGTSAGGLIAALTCTRTDDELRRMLVPALADRITACEEPFSVWARRAWATGARFDTVQWAEKASFFTRGSMTFKEAYERTGKVLCISVIPADRHSPVKLLNYMTAPDCVIWSALLASAAVPGIMNPVCLMQKRKGTGEIVPWNWGHRFKDGSLRVDIPLQDLHALFNVNYPIVSQVNPHVHLFHFGSKGSPGRPTAHRKGKGWRGGFILSASERILKLNLSMNFKILRDLDLLPAILGQDWSSVFLQRFGGAVTILPKTRAWDWVRILSDPDRKELARMMRVGQSVTFPKLHMIENRVRLERAIEEGRKACRRAARASNGKGGRSPGAKVQPLPTLDGSRTSGESARRSHEAARRASGDEAPRSIASLPSDTDGEDFFTSKDVAGLTKVAGGMAGVLLDSAVGTPNSVGDAPTPHEGAKRPKPYPTYSRYLIDTQGTGSRPDGGRDGGEEISDRAVRDWLDRSHGRAEGDANANGEDEAQAQMPFLSAATHSEGVTRGARRASFGTAPLHHRLRSLHGHGSWDDRSQDFGDDDDADAALDERAIYESSGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK20</accession>
    <name>W3VK20_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK20"/>
    <dbReference type="HOGENOM" id="CLU_1468794_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="184" mass="19116" checksum="3C9B6B92B62CB6AD" modified="2014-03-19" version="1">MVVAVASNRCALATADSHDIGPAPLGPSQAASPPSCVPPLHQPRPPSLPVDSSSRAPPALALAFAPAVSHTPRSPKHSPNSPPDSTTRNVLSSPPRYPAKPGTQSRTTHHLQPAEAFFSFTLTSSSASIAHSPEFDLNLDLLTNRVAALSLLIAEPVSAPYTKTLCQARRSSSQEEIGPPASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK32</accession>
    <name>W3VK32_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK32"/>
    <dbReference type="HOGENOM" id="CLU_625726_0_0_1"/>
    <dbReference type="OrthoDB" id="2556119at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="438" mass="48630" checksum="EE9B2FA75656F6C6" modified="2014-03-19" version="1">MSKRKRTSTSANGSEDDEREEANSSRSSESGDEEADDVKDVETRDGEEPDVGDVTTPVDTKESEPRYEVRAIWTAKDPRVWSFEEYPDPTSRDDLARGTRRFRYLGPFRHLSWQDLNDMAHEVAHFIWQTYSHINPLEVFVQTPTVRNDVLHLDIATTTQKAYEQLAKAQLGFRSKPFELVSSCAPFPSHHILMRIDGIDVRNALVSIINSIKVELHGLMRVIAYWARFRPRSDDSVRSGDDFTGTVYVLGAGRGDKVQIDKLPGFLDFKNLGWPKRVAVLPTNDITQKVNSLMNMVFAYGGAMIAERTAEIPTIWRVYSGATPQPRGESARHTQGLCIVKADRASRSAPVSDETMIERANQSSERDQSASSPGDNDLCSSRWLRNSAAATAASPIFACCAVAMILSRSSNDSALFSPTVYSGCRPFLLAQSAVADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK49</accession>
    <name>W3VK49_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK49"/>
    <dbReference type="HOGENOM" id="CLU_019358_5_0_1"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.20:FF:000008">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF20">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="6">
        <location>
            <begin position="118"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA2" evidence="7">
        <location>
            <begin position="332"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="505" mass="56142" checksum="C8C780D49F3FF6A2" modified="2014-03-19" version="1">MVSLRGKKERFGAAAALVVALASAFAHGRALPQRPVAVFAVQSELAPPSIDGLVEQPHVACAASTFKASENTFADGVLRPADYWASEEGVGHFSEWSKSTKHDFIADWALGKASEWTIVMGNEGGDLDSLAAALAWAYHLSHSTLHHPQPRKAVALLQTPLDALDLRPENKLALDNSKMSSGHRDLLTIDELPAHPRAIAKQIRGIILVDHPLPLSVWADAEVLGIIDHHADRGAAPNANPRIFETAASCTTLVARQMLDELEAIPGPPDGPGEYHMPHELLELMLDAIAIDSDGLNPKKSTKTDADVSQRVLERSNWHNESLSQVMDRLDKELGEAKRDLSHLSVRDLLRRDWKGDVVETTDTATPAIHLGFASTPVSIDDQIERTERKSLKDWFRVERRWTAEIRADVSICLNKYKDHKGNKVREIVLTVRHDHRINRTQADDLFRVISSALNDSFDLEEHPKMKHHAGKKRRQIVWTHGRKDAGRKVVRPIVERAVKSWISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK79</accession>
    <name>W3VK79_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde dehydrogenase ywdh</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK79"/>
    <dbReference type="HOGENOM" id="CLU_442872_0_0_1"/>
    <dbReference type="OrthoDB" id="2550461at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="617" mass="65619" checksum="7B09FE1B7F1E3A59" modified="2014-03-19" version="1">MSTQLLRGGNKDDLFEGEVKTPGQLPAQMYEFEDVLEHIHEALVEKRVSHNQAYRFKVLETIFSFFETARSQLLEAASQDFNGKAARVELELEYAFTLSQIAAALQSQCKPVVPGGALPDRFFSKLTIAGNAGGKDAHVTVTRPVGAALVVAQPKRPFDDLFAPLVSAVAAGNVVCAVLTPTMPSLNKVIVEQLTPQLPKSAVFVISPADMPAAQHGVADLREAASGVFGVEVPGSSHVATRISVPGSAYVSASLATAPPSSLPLGLGGNASKVVAERLRDVATEVVEGASMLLGRGVGAPKYLFVHEETYGVFREALLLAIATSSANLAPRDDGSKLEEVLQIEQTIGSKVANCGGSARLQKPFASEKRPGPVALIEVDVEAARAAKLSAVISDRKVVAQIKDLAALVLIGVSSTEHAFGLIEELGLDRGHMSVYSHDSAEVQHVLREVGPATLSINHIAPENLFSSYAPKPLPKSSVLHHHLQQQAGKVFGETSGLRWPLELFQNASSTYLAATRSTSLGLSGVSVSSSAARSALSSSSTNQRQLAVRKALAVHLAKTKRLVKRSRPTVSAPILRVFFLQGLFLFWGSALTCTLGGISYGAFKLSHWAWMRYVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKA2</accession>
    <name>W3VKA2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKA2"/>
    <dbReference type="HOGENOM" id="CLU_759041_0_0_1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="361" mass="38666" checksum="53135B20194A0FED" modified="2014-03-19" version="1">MSDATPVKRAGSTADTEEDFSTVPTTTAPSESGFEDLSISETDSNVRVAASDTSSTPAAASEGVNAAVPAAAPARQADEPAAHPTRADSTSLTSSTSGLVLFDLTDKPGGKACFSPHTIKTILDLKLLNVGYERQRLTFVQIRNELSERIADNVTVPALELSDGSHIVDSWAIAEYLERRHQDGHRLFGSSATKRLAAMLNQFGKTVLAPHIGPLAQRGVHAMLDAESADYFANVKIGKPRWAKVSSMSQADVQNHVQQAIAKLEVVNAMLTCEGGTDSTNGAVSYSTHSATTPQPRSSKPVWFAGGQDPTHADFVLFGWYVFSRAAGAKIANEIWTAHKPIQRWLDAMLEWSGDLADDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKG9</accession>
    <name>W3VKG9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05253</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKG9"/>
    <dbReference type="HOGENOM" id="CLU_028132_1_1_1"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000658">
        <property type="entry name" value="COP9 signalosome complex subunit 4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PSMD12/CSN4-like N-terminal" evidence="10">
        <location>
            <begin position="170"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="468"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="635" mass="67973" checksum="1D180BBB7BEB78F3" modified="2014-03-19" version="1">MHLRHHPADTLRYPTTSSLASEPLRDVHRSSGTTSVPARPEPLPLSSGVPRHWAERALLPLVKMASSAASFTENLQGASTQTNHARAAAYEALIMDLLQAPASKVSRADLLEATSAYLRHAVFSEQNATGGGLVVGRQALTALEHHAGHIAAEHEAQKSDQDRMQDVEDENMPAIADSDTRRQVLENALEQLQPRVLSFEEQASSLRMQLASLLEADEDWNEAARVLLAIPLDSGHRNVSDHFKLSIYVRIARLLLEGDDPVAADMYLKRASMIIHNVPGALPSHFQQQQQQQQQEGEASAQTTSAQTGSMDGSGNDNSSGAAGAKDKLEEPKVLGLQYRLSQARVYDSQRRFAEAAVRYHELSYVGEIDEDDRAMMLSAAVTASILSPAGPQRARMLATLMRDERTPSLPQYTILSKVFLDRVIRADEIADFEKLLSPHQIAKLAPSSAPIAVGDSTGESVRHAPSTVLDRAMIEHNVLSASRLYDNITLAGLGALVNLSPEGAEEIARKMIMQGRLKGWIDQVGSSTDEASARARGVLFFMDQERRGEGETTAGGLSATKDVGASGGDGSGSGAGGASGDEGAGSGGGTSDLDTKWTRRWDQQIASVTGALEDVCQRINQISASASAAASATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKM2</accession>
    <name>W3VKM2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKM2"/>
    <dbReference type="HOGENOM" id="CLU_2110030_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="115" mass="12301" checksum="66041C727642743E" modified="2014-03-19" version="1">MAYLLRACVVCSSVGSERIEVARIEVARMRSDAIGLRSTRGGVPIATILIMRDAWKALIHTSSSPLANGADAGYFEPGMKLMRISRDTINCGVADWTLISASMSGEAGMASHHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKP2</accession>
    <name>W3VKP2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKP2"/>
    <dbReference type="HOGENOM" id="CLU_023225_0_0_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="53433" checksum="BF88C01516528D7E" modified="2014-03-19" version="1">MSSSLFFGYPQLAVIPNAGILGLTAYCFSTVAPLWAFGWLGPQIRRICPDGFTLAEYIRRRYGWPVGVLSGLIFVGFMFCFMLVELNTYGSTVNVLGGVNPTIAALIVALSTTIYTAYGGFKASLYTDNVNAVIIMIFVVIATIAVGVNLDIDHARVESSGLLKPQRLGGELWYILTAALVFSQMFNQGFWQRAFASKNNKTLYLSVIFATVPLFAICFIVGMAGPLAWWAGLFDGPTAEDDGSLTFFYIINTLPNWVTGIVIVLAGCLSSSAYDTFQSAQISTIQNDVFLGRVNIWWCRAILVLINVPSVVLAVKNIDILEVFLVADLAAIACIPAFLLGLVPQLYFLNGVDAVGGAVGGFLTVFLFGTAFYGSAEQGIKLLGLPNGLYIDDFSVLGAFFAAPLGSLGWTFATFGMRAAATWVYCRYTGRAFNVFEYREFDVAKWALPEDRPADFHGVHGSGNPNDGHKLEDPAVLPEGAKLKRYGSEASTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKR8</accession>
    <name>W3VKR8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKR8"/>
    <dbReference type="HOGENOM" id="CLU_821660_0_0_1"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="362" mass="39152" checksum="3B52F5C32376249E" modified="2014-03-19" version="1">MSASFRSEVDTYLKFPPAAERQQTMALSIFVPIGYVATLVVSMLVFSRIYRRRSALNLAKSYQPWFPEGHEARDIYQTLVAADPPAPEEVLKAALLNRAMTDVRRIMRMRDDKQALGTLLQKGSIGDETMARFTLAEKELEAEILDVVSEANTFREGWGQLIFPSASEMVAHLKHKEIYYDIQRQRAAEVKKLEDEGKPVPKANVELPPLVTPPGTKIEIPGGPGGPGGPMPAPPQGGPGPNGPGISLPMTGSGQDARVTLPNGMQLHPAQLQALMQGPLPPNMPPQQAAMLMEARAQLLALQEQAQAQAHAQAQAQQQQLQPADANKENDQTPAAAPTEAKLETHAAPSTKTATVEDGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKV8</accession>
    <name>W3VKV8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKV8"/>
    <dbReference type="HOGENOM" id="CLU_466295_0_0_1"/>
    <dbReference type="OrthoDB" id="3358973at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="559" mass="59110" checksum="65DEB4FBE22A99E7" modified="2014-03-19" version="1">MTDVDTSVAQASLANGKSHANGHFGSGSSGSQATATHPAEHGIPDPLLSDAFGPSSSLKAISSGDSTGKGKQAATDSATTYLDSDYHKATSSLTPIDESPTDAAFSYSYQDSYRSSANDYAHQSSSHRTSDHVRIDSPDMDEVPYSPTTYPPISEEDSEAKRVQQNLERWAAEERQRRKAQRSSKLLANRNLVAAGTGGLAQRLSILRTSAQTNNNNLGAGPSSERLADGPGASPSMPYDPRLGAADRRGSGSSSAAAGQGLHRSASSSSFDSSQSLGSLTSDDPRPNRRLPPIGSRVSSATHARNTSSGSGGSLKGFGTTANGSARNPFRDPSDGGAPEVTLEKRASLKPQPTASRPIVTVGRASSIQRRALESGYNSKGKGKGRSMPTIVATDTEAEAEAEAEMGRISSRVDDENPFASSEDRQPRARTESSTMIHEGGLDEEVALEMAGRAQAELNSGDIGESSLSTDQPIRPPPGRTSTSSSKFRELGITEGDDWIETMGRSLGKGRSRKMRIAPHADGDETAHEPRKPWWTELLCGCSRDEDDDEQAGRTNPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKX7</accession>
    <name>W3VKX7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKX7"/>
    <dbReference type="HOGENOM" id="CLU_073901_1_1_1"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="167"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="326" mass="36457" checksum="17F6497B5E75C0BC" modified="2014-03-19" version="1">MVEDTQRSLRPYQPVPERSPSLRGTVTARTRRILRQPLIYAAPIAPEAPRQPQCRPETQHRRFFAHHLSSEPRAAHARGVLWSTMFVLADIEDTISVHPSAFGQPSLTSISDQINIKYANKILPDVGLCVSLFDILSCSEGKVRFGDGCLYHHVTFRLVVFRPFTQEVLTGKIKSSDEAGIRITMGFFDDIYVPAHLIPKPCAFDHQERAWFWLYEARTDEIAADPLLSHPDERMYLDTAEQVRFTIESDEFWDAEPGPIANPTTDSAQSSALHHNQHTAKETKPHYSITASIAGSGLGLVSWWTGAEAAAPLEGQEMDASAEPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL18</accession>
    <name>W3VL18_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dhh family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL18"/>
    <dbReference type="HOGENOM" id="CLU_034130_1_0_1"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="502" mass="54122" checksum="2A81EBF3C24A6980" modified="2014-03-19" version="1">MSTRPVLRLAPLLRPRPPRIPAMTAAAKRSAASASLSSPSKRAKPAPVSKSRSPSPTSLQMIVARLSESHPEWPAPPTKLREAAEFLKACTASPASNRILLLPDKDADGLCSGAIMYRTLVHALGISPARIDVHLMTKGAHPGASAQRQAIAGYGAKWIIVLDQGSRTGPAIVPGAEHGWRSKNPDAVATMVVDHHFLALGQGGPEGCLMLNACHHEPVATASLLTWVLCRPLWSVDADAEAQVDYLAVLGTMGDLSVNVSWQPPFPDLTPEVKKWTKKRLGSAIALLNAPRRTPEFDVSTAWSALLASTSPLTILDSATNEHAARLYAAREAVLLETERCTHTPPKFTKDGRIALLRITSSFQVHPSIATRWTGALKSNKLQAVMCANDGYTDGNVHFSCRIANAAKARGEHVDIIQLLHEYARRDESWLNELMHELGGNAFNGHPQASGGILPTHHFEKFTELMQIGVPPDTKRSPAKKPAQKNTLLAMGFSTSPKKSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL28</accession>
    <name>W3VL28_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL28"/>
    <dbReference type="HOGENOM" id="CLU_405007_0_0_1"/>
    <dbReference type="OrthoDB" id="3346251at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="68794" checksum="01B184ACB386FF31" modified="2014-03-19" version="1">MSPEALPDDWMATVCNGTLRPAEAAAFLHRHFHSHNEFEDDIAIVAATLYCWEFLMTLPAELRIYLTIPWTAPHLILFVLMRYSTMVTVAMGMYSTWHRFRGNCVTYRDAAVLMVQLSVSAVLGWRTVAIWQKDARIFVIVALLLITLMVFSSLIVLGTHVQPVSSGECILTRGDVEELFPLAWFYAGTVAYDTAVIVLSTFRLWQHHNDVGVFPGANADDSRRWCSWISWLHSQWNSVTPLLFRLTSNGVLYLAFSTVFNVVCFAVSYDNEDRAQNLLLLYSSVMWVVCQHLMLLEIRATWGNSSAEQKFGTKGPVDDSDADRLIAQILQASWSQKARGEAKTLTKTDGGKDIELGPTLQMGCGCGPGGGCSCAGVRESLALSLRDLALARSRSSDECDTTKLSVQQLHGFRPCMPGESYDGSAQSSMHRVQTAEADTSSTALVTDPTDEAADGVSRGFRGRLSAISNSPTRLFATFKTRSDGPTALDHPLQHAESSHCCALAQKAPARSRRFSQVIKKAAPVSAEPACNCRRPRRNTLGTLQPPATDLQACADHQDISCGRKAQGIEVAAMLASMSPDDKAAALALAGMDASPALPSYPPFASTMHPQRASPAKVPTTIWMMQPPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL46</accession>
    <name>W3VL46_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-actinin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL46"/>
    <dbReference type="HOGENOM" id="CLU_005217_0_2_1"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="136"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="364"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="71667" checksum="FFCE5298698BB2C5" modified="2014-03-19" version="1">MAYKRSSVLVGLPDQDRGWEEVQAKTFTKWLNTKLESRQIAPMRSLATDLSDGVKLVQLMEIMGDTTLGRFYMNPRMRVQKAENVNLALEFIKSRGVVLTNVGAEDIVDGNLKLILGMIWTLILRFTIADISEEGVTAKEGLLLWCQRKTAPYQEVEVTNFTTSFKDGLALCALIHRHRPDLLNYDALPKSDPHACTRTAFQVAEQHLGIPQLLDVEDLCDRAKPDERSVMTYVAQYFHAFSSMEQAEVVSRRVATFADVMQGAWLMQQDYERRARELVETMGNLQAGWVAAKFAGTYADARSQLTEFNEYKIGVKRELVRERTDLAALLGNIQTKLKTYHLPEWMPHLGLRQSDLDAAWATLAEAEARRSRSINAEIRNAKENLRIKFANAANAFERQLREVAGGIATLEGDLEGQEVVVKSLLAQLDPIKDGLELISALEQACTEAKVEENDHTIFTLSDLAFEWELVRASVSKKLAFIQNQIVSRQHTNLTPAQLEEFESTFRYFDKDASNTLTVPELGAALASLGIIYTEDDIEQIHLQLSETFGAVSYDAFLTFLREITEDTTSPDQLLEAFQGLAGDKPYVTELDLRLALLPQGSIDYLKAAMPQVQVEGVEDAVYDYEGYLTGLFGVAQAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL66</accession>
    <name>W3VL66_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-coumarate--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL66"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="53"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="460"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="61400" checksum="5AE4D03D68976A6E" modified="2014-03-19" version="1">MTQKVGQYTEYDASAGIYSSRVPYSPESASCIFEYLLGSVGFDDAQEVLRECASGRTISLGQLKLTAQRLGIGLIRKCKLKPGDTVLLYLYSSIDFAVALLASQFAGLRVALANPDYLSTELKHVYRLTKPKRVFVTSKYMSRLSRAAIAGQTLILTDGDVAGFGGVSSIKSLMVDEFTAQEAKAHTPANLNETAYLPFSSGTTGLPKAVEISHSNVINMIEIFRHTPALFPKADDGSEEQFRTLTFLPFFHAYALILMLHYPIRARGHTSIIRPFQPEAYCRLVKELKVNFLALVPPVLTLLTKHPDATPEAFSSVKQSLCGAAPLDFETQSQFTKKTGVPVQQAFGMTETTVGALGLHGDEASGSVGCLYPATLGRIRDVETGKNLGPGERGELLVRGPQICKGYYGNKQATADTFTEDGYLRTGDIAIVDPRTGEFSIVDRLKELIKYKGFQVAPAELEGVLVSHPAVAAAAVVGIHDKDQGTELPLAFIELKAGQQDISKVTQDIDAFVRSKVSHHKYLRGGIRILDKVPVSASGKILRKEIRKLLQAEIEAKASPAKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL69</accession>
    <name>W3VL69_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03354</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL69"/>
    <dbReference type="HOGENOM" id="CLU_048437_3_0_1"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="13">
        <location>
            <begin position="29"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="313" mass="33558" checksum="689974CA1C8A9884" modified="2014-03-19" version="1">MSDSASSQAPKAPTTPNRRPEVCGPHAPERPYPIYLRGQVEKGFGRGSKDLGCPTANLPSKVVGPGSSLTRTGVYFGFARVLPQDSDDPSLTDSEDVDIPGSSHAQTASSSAGYDDDDDNEVVLGASPIGDMGEGFLDSGLARPRQNSRGQPSPASVLGAATTSADPRADKEAEVSRSEVSNGASNAAPAGSFHGATASTSSSSSSLARRRKTKRVHLRPEDSQVFPMVMSVGWNPFYKNTHKTAEVHVLHEFASDFYGLEIRVVVLGYVRPEYNYDSMDALIEDIEMDKKVTVNSLARPLYQDYSQDPFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLI7</accession>
    <name>W3VLI7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLI7"/>
    <dbReference type="HOGENOM" id="CLU_2360642_0_0_1"/>
    <dbReference type="OrthoDB" id="3351992at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="96" mass="10772" checksum="FCDD8C42EF25419F" modified="2014-03-19" version="1">MTTTSKPVPSVIRPGKAPEGPPGWEERRIEKQINDQQANERRNHRRESSTGLAGIKEKVHKIGEKMHLVEPKDPTQRTAAQLQDASTMPEKAPIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLJ4</accession>
    <name>W3VLJ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLJ4"/>
    <dbReference type="HOGENOM" id="CLU_268857_0_0_1"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834660" description="Transmembrane 9 superfamily member" evidence="10">
        <location>
            <begin position="23"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="757"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="846"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="912"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="942"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="975"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1015"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1140"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1193"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1045"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1103"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1219" mass="133723" checksum="166150E698ED69FE" modified="2014-03-19" version="1">MRGTTALAALAVALALPLQAAAWYLPGSAPHSYKQGDQVPFSVNALQAKAFTSQIKGVLKYDYYDPRFQFCTPDGGPEAQSENLGSVLFGDRIYSSPVQGVMLKDEVCKQMCRTTITPENAAFINDRIREEYAVNWMVDGLPVAESRREIKTHEEFLSLGFALGSLQDEHFQQYDPPALHNHYDIYIDYHKRGPDEYRVVGARIYPLSKDSLTGVAAGQPADCKAANPLQLSNATSTGVAYTYSVRWRESSTPWATRWDAYLKVFDPRIHWLALINSIVIVSFLCMMVAIVVARSISRDIHRYNAIDMNEDVQEDFGWKLVHGEVFRPPGRPMLLSIFIGSGSQLVAMAAVTLVFALLGFLSPSNRGSLATVMIVTWTLFGSIAGFVSSKVYASLGGEYWKQNIVLTAMLFPSLVFSLVLLLNFFLIFSGSSGAVPFGTLLALVALWFLINVPLTAVGAMLGIRSGGFTHPVKPNSIPRQIPYQHTWYLRPLPSAMIAGILIFASAFLEILFILNSMFGTKIYYAFGFLALAFIITAVTSATVTILFTYFHLCSEDYRWHWRAFVTGGSGAIWFFVYGLFFWATRLELPGLANKVLFLGYLSILSLLFFTLFGAIGFLATYAALRRIYSAIRVDYPTSISPASISPASISSPLASIQPATTLSPQLQIRAANSSVTFFIAGACLLANPAHRSCATDSCATEPFQIAMGVALSLPFLGGGLASIASSCVAGLAFFCTSTAASAFFKSCNCQSSIATRVGFAIIFCLDALLAWLSLTGFMMHKIEEWSYNYIKMDCKDKDRCYGVLAVHRITFALSLFHFILGMLLIGVKDTRTKRAAIQNGWWGPKVLLWLLLTLLMFFIPNGFFVFWANYFSLILASVFIVVGLVLLVDFAHSWSETCLDRWEQTESDFWKLTLIGSTLGMYAATIALTGVLYGFFASSGCSLNQFFISLNLGLIVVLTLLSISPKVQEANPRSGLAQSSMVAAYCTYLIASAVMNRDNAECNPITRGRGGSAKTTTVVIGAVFTFLAIAYSTSRAATQSTTLVGKRRAALNESRPPSGYGPLATRDSLDYSSTGVVSDQPTKKDSLRIQALMAAVEAGAIPASALDEEEDDDEIETRSELGAADESDDERQGTRYNYSFFHFVFAIAACYTAMLLTDWRFVRLGGPSPDPSEDGAPIAYIGRSTTAMWMRVVSSWLCIAIYTWSLVAPVILPDRFGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLK8</accession>
    <name>W3VLK8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLK8"/>
    <dbReference type="HOGENOM" id="CLU_033470_0_0_1"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="403"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="543" mass="59580" checksum="9E3AFA9AB958DB14" modified="2014-03-19" version="1">MTSSRPSSEDSRGFSLKDAFKRLSIRARSSSPACDAQHKPASTALPRPASYHKAATSASTAVSLPPYLAHLAASTSTAPRPRPFPEPRVSITAPAPPPYDHDIEPHRMPPRPPAFTSAAPEQQPAAHKSAPSRHPTSLTPANIRVDVHSKQPYPWELVPQLKARPGTSSAGRESSAPSDEVEKENRIPQSNSAQQTHAKTTQEPINLVTPPRAPGKLRQKSPSPSTPLGARTPNGSQRDPSCPPVRGQCWGIKQDGTRCTRKVRTPSHTNKLAPAGTPNERSRYERGASAPPMLHQGASAGQPLVIGDSGSEDELGTAVARRQRLASPASKDAADDIDEVYCFQHVAEVNKTTGFYPGTRSSANDFVQFSDWFGTVELSEHAQALLRRAMSRPPTDFDRAEQGYIYIYELRDRSSATHLCLKVGRTVNVFRRLGQWRTRCYSKGPLLRAFHPSAHDQGMLSGADAVEAPGVVLSHRWETLVHLELDAVGQRVLEVCHDCGTRHREIFMIPRSPRLQHGQEQADGFEVVQRVVHKWMRFVQAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLQ1</accession>
    <name>W3VLQ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_04174</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLQ1"/>
    <dbReference type="HOGENOM" id="CLU_019713_0_0_1"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="744"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="488"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS61676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="797" mass="89729" checksum="C4FD00865A269028" modified="2014-03-19" version="1">MSSSEDRKRSLVASTDDGPRKRLHSDENASRSPIGASDDQDDEALHPAYAGLDAFRKEAIYRKMLEARRDLQRVERRAATFQDDLAVSEKRAAILQRFWSLLLTDLANRLAIRDQQALAALASSERPLEPSTMEKQLQDQSALILQSLSTQADGDLAELQQRYHDLAEEASRHKQDLFLTQSKLQRAEDALAHATQKLSKVEHEYVRYQSNLLRATEGKPTVPAGTTVDASAPPPTTSAPADESTVTVKKEEGEASNAEASVEQSEALQKATEQLESARQDVELTRRESDSRYAEIQTLNEEVRSLKHRLHETQLKLDHLPEDVLVRSALYRELETAYQHAQQDLQGVRDSMHTLETEANALREERATFQQTVEAEASARTDELEKMVKAKEADVTRLRSQRDELNAELTERRSREQVKFTQIEEMKALLNSKEERLTLLTSQVRRLRMSVSAFRGQSAGVTALAETESEEDQFEKLSRAAQEAQARVAELEKRLSSADTPTDGAAVNGTTSADPTEMQAEVERLRLSLQAAEASSKAVDDELEKISAAYAELERQASVKVTDVSRMEEKALRWVTEKSKADNKYFSTMRAKDTVDAELRAVKQVNERQQKTIEMFGEVERSYSTQLGQHEKEVTVFKKAIEVHSRRIEALSRDLEQANARLAEAAQTSARASESAKEFIDAATTEKDQRKRADERIARLEKDLESAKRQMARAAASAAKNKGKREMDAGDGSEKDFLNALLQCSSCKERYRNRILTKCYHTFCSVCIDTRVHTRQRKCPHCGLAFAVSDVQQLFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLS8</accession>
    <name>W3VLS8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLS8"/>
    <dbReference type="HOGENOM" id="CLU_010228_1_2_1"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="684"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="230"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="756" mass="82706" checksum="85435A5A6CF86EE0" modified="2014-03-19" version="1">MSAQHRPSPLRSSDATWVTSSIIDSSTPVRSSSSRDLVPAPRASDLQIILRTREHAAYYDPTSNELSLQKWPLPDPAEPAGAQAPLVRHRSSQTNPQTVLQRFHPPSPLPSPQLDSVCPTCARPWPLNTAEPRGADFTASRGFNDDAEYDAEYDREAPSYIAPNYFRLLAQATSTGASGYTTRPDTPSLLRNRFESASGSSTPVAASGTSTPPEPLQHDAEAQGYYARFFVELKRLGRGARGTVYLCQHVLNGNKLAKYAIKKIPVGDHAQSLLHSLNEVHLMESLHHPHLIHYQHAWIERCQLTQFGPNVPTLFVLMMAANGGSLADWISARAGDAAGAAEQLDSHSDNGPRSAHTTTAAESPQKTGRTDDTASDRRRIERLKAALRQRRANRKISADDATSADLPTTSAAAASVDGAASAGVGVHLLREEEIYSLLRDMASGLGFLHERGILHLDIKPGNVLLHWDDDSLVPRALLSDFGSSLLLHDNWTRTRSGHTGTMEYMAPEAVFPDTTGRLAELSSKADMWSLGVVLHLLLFFRLPYKHTDVDRLRVEMMAYSGFDRARCDTAGRRDDKLLGLLESLLQRDPVRRPSCKDVLRVLDEAQHAAKAKRERRRSDDHRARVSLALHRPAALPPLPAHTLGDPQHRNRRTWWQSVPSEAQHIGVAFAKCLSPALVVHAPSLGVVVALATLVLLALVDLVAAVTHAPHRRTISLTTAAAHVAILAFLARFQGLDRTLFLLVSPAHMAILASMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM27</accession>
    <name>W3VM27_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03259</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM27"/>
    <dbReference type="HOGENOM" id="CLU_031625_2_1_1"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="119"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="223" mass="24596" checksum="6F0F17D574C5A982" modified="2014-03-19" version="1">MLRTALTRSTRALPASTRGLAASVRAKHTLPDLAYDYGALEPSISGQIMELHHTKHHQTYVNGLNTAEDQLAEALHNKDVKSAIALQKAINFNGGGHINHTLFWENLAPKKNGGGELSNGALKDAIDRDFGSLDGLKQKFNAQIAAIQGSGWGWLGYNPQTKKLDIVTTANQDPLLSHVPLIGVDAWEHAFYLQYQNVKADYFKAIWEVINFKAAEERLQKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM46</accession>
    <name>W3VM46_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM46"/>
    <dbReference type="HOGENOM" id="CLU_1807033_0_0_1"/>
    <dbReference type="OrthoDB" id="2556009at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="143" mass="15539" checksum="94536E817CD896CD" modified="2014-03-19" version="1">MTIDQYQQAIAGAGAGAGAVAGAGGLQRRDLYSYDMGSLLIDNVLHKRQDATEPAKAPAKVLMCINGDPDVPAIKFNTMTELRIRDASAQQDGVMQVTNLPNYQTPWMPFLPTADMWAEQQTLMIEQEKIIETNMTTAPPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM89</accession>
    <name>W3VM89_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM89"/>
    <dbReference type="HOGENOM" id="CLU_014832_3_3_1"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.20:FF:000001">
        <property type="entry name" value="Ubiquitin thioesterase OTUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="9">
        <location>
            <begin position="68"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="355" mass="39262" checksum="1E641309CA8F4219" modified="2014-03-19" version="1">MEGINADTKLESLTDAQRLELAEKVRAESTAGQPLISSVEPIEVLEHEYANNDAFLGKIQWLKEAGFIGIRRAKGDGDCFYRAFAFAFIYKLMTMNDRPMHHFTVKHVDSTLQLLKDAGYDESVYTDFYEPLRNLLNRMYSTDPETKELNEHALVEAMNDAEQSNSIVVYLRLLTSAFLKLNADEYTPFLFSLDTHTEAAAPDMQSFCANHVEAIGKEADHVQITALSRALKVSLDVAYLSPAQAPPATPLDEDFPAEQIQSSEHNAQSSNSIPIQSSEHNAQSSNSIPVPGNEAASRRHAADNPNRCDVVRFEVEGGQITEIGTMLLRPGHYDLLVQAPTPASPEPEIPAILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMP3</accession>
    <name>W3VMP3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4336 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMP3"/>
    <dbReference type="HOGENOM" id="CLU_056292_1_0_1"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37714" checksum="FB87C9FA98EA77B0" modified="2014-03-19" version="1">MKLPTVAQLVTHRPYRPHSLTSILCDPVTTRHLSAFKPSAPIQKTRIRRYSSKCCSIDKMATSSKPGASGTPVYIQEVTPEITTFDYPFSRFGILPIGGRSIAIRMRDGRLWVVPSTPLDQPTKAKIDAMGEVAYLVAPDNVHHLFLKDFHAAYPAAKVVGTEGHEEKRPDVKFTGIYGRDPPTTQYGYEAELVPQYFATFANRDVAFLHKDSRTLITADLLFNLPCNQQYRNTPSGKATSWIPGVIWFSKLFNPYSSFHKTFLGGAGVASGLPGVANGGSKEERKKNFAEAASTVAKWDFRRIVMLHGDIIENHGQEAWRAAFSKYIDNEGNSRFKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN88</accession>
    <name>W3VN88_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN88"/>
    <dbReference type="HOGENOM" id="CLU_032410_5_1_1"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="306" mass="34559" checksum="6C7DC1F6A26DA605" modified="2014-03-19" version="1">MGDSSYKGVSASQDSRFTDKEASLLRKLKFPRHFDTKVDMHKVELSVMKPWIARRITELLGFEDEVVLEYAVGMLEEGRYPDAKKMQIQLTGFLEASTAEFMAELWELLISAQASPGGVPQRFVEEKKQELRSKREEGERVVREARERATRAAQAAGSSNDAQSAKRRSRWDAGAPSDSSFRGQADSRPPAYAPPRGSEPYRRSDAGRSFRDRSGNTMERSRDSGWGVRGSDATRPADSWRPSRRSPSPPPRRSPSPPPRDERRRSRSPSRSRSVTPDYRAAIRERKAKRAATTRRSRSRSCSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VND0</accession>
    <name>W3VND0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carbonyl reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VND0"/>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30834" checksum="B136469DB4436F43" modified="2014-03-19" version="1">MVTALVSGGNRGLGYGIVRRLANEFPASSLYTSPSDKLTIYLGSRDVSKGEEARKSLYAELAKDVLDRVSIEVRQLDTSSHDSVTKLAAELQPGIDILVNNAGIAMDGFDANVAKQTVATNYYAVKDVIDHIPVKDGGRIVTIASSTGVLRGFGDEVRDRFRNAKTVEDVDRLMEEFQQVVADGTWKEKGWKGAAYATSKSGVIAYIRALAEVYKQQGKRVDVFSCCPGYVNTDMTKGKGHKTLDQGAETPVLLALHKTDAKPGEFWFEKKAYDWELRQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VND1</accession>
    <name>W3VND1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tumor susceptibility gene 101 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03813</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VND1"/>
    <dbReference type="HOGENOM" id="CLU_017548_2_0_1"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="591"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="70668" checksum="A936891C72990CC7" modified="2014-03-19" version="1">MDHAVVQRWLRSVLGPYNDRDRVYADVDRALIAVSSLSPKTEVFTFNDGRTQLLLTLEGTVPVEFRNTTYNIPVAYWIPRDYPREPPMAFVAPTPDMAIRKGPNVDPSGEIGGNYIARWRSKPEACNLLDLIHDCQHMFGREPPVYAKPKPTPVYATAASSQQRSQPSTPQQGSSANPLAQRPGPSLPASPRSPQVVGSPSFETRQKPPPPPPGPDSAHHDHPQGSFTPQRPPKPSSSMGFDRGGFHSPRNSSSHFDPHQSPAPLPALQTQSPHTFSHPPSAGPDVNRRASGGAYGPGVYQAPFGAPSPQAHFAPADRPQPRIESSHSPVSPSHRPAYAEGRPYAHGHQSTPQQHPPTRAQTYPYPTQEPHPSHTQHDNEPAQAGVRLPVAQGYAQPGLPRANGGGPPPVPGPLPYASASASQAPNPAAAGVADRNGVPARPAAAPRPKSVNLLDDEDSALGLSDTRGQANGIALAGGPTSAGSSAPPPPRPINPELLALHERVYVKIDQRLVTLSSTLQASNQRLEVLSSDLDRGLPAIEDEMSRLKAVRDVCKITGDRLQGSVDEITESVRSIHARDDPDPDSMVLATSIVGNQLVDLVAEDNAIEDTLYHLGRALNAERIDLDRFLKQTRMLAREQFMKRALAHKISEGMGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VND8</accession>
    <name>W3VND8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VND8"/>
    <dbReference type="HOGENOM" id="CLU_110455_2_1_1"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="187" mass="21641" checksum="5DDD820B37F50215" modified="2014-03-19" version="1">MVRLASHGRPTDVTRITPLQVERTRAKLSYAEPLALTVHPSAFHHPRATYAAMSLARTINYIRKEGIKKFWRDLNYIGDAKSGRLVGIDRNGNKFYENHDEFPLRHRWVDYAADNEFNASQVDPLWHSWLHHIRQKPPHEDAGIQKMTQSWMTPPRENITGTRGGFKTYNTTKPKISAWEPKVAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNJ2</accession>
    <name>W3VNJ2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNJ2"/>
    <dbReference type="HOGENOM" id="CLU_1611489_0_0_1"/>
    <dbReference type="OrthoDB" id="10687568at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="165" mass="18766" checksum="27546062F116112E" modified="2014-03-19" version="1">MDNSNPAKLNTRSAVDFASNILGPARERDRILFTGKFFRAEIETGVAELADKTFPTQGGGSVEEMTAIHDRLMDEVIIPLTDKAITVAKEVTLAKEEHAYFHSSLRKMYLQPPGDRTTGPFTLKRERREEDHLPKVHEFHLTIRQDNLCRLSFVLQTPARTIYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP12</accession>
    <name>W3VP12_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01691</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP12"/>
    <dbReference type="HOGENOM" id="CLU_010194_18_0_1"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="776"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="912" mass="98323" checksum="45A65799B755E321" modified="2014-03-19" version="1">MSDFPSTENGKISFKNRVVVVTGAGNGLGRAYALFFASRGAKVLINDLGPSAKDKNKKAADVVVEEIQQAGGEAIANYDSNTDGEKVIQQAIDKWGRIDILINNAGILRDKSFKAMSDKEWDQITAVHITGSYACAKAAWPHMRKQKFGRIINTSSAAGIYGNFGQANYAAAKHAMIGFGKTLAIEGAKYNILSNVLAPVAASQLTATVMPPEMLENLTPDYVVPIVAYLVSAENKEVSGHVFECGAGFFAQVRRERSRGVVFKTDDSFTPAAVRAKIDEILDFDEKPEYPFRITDANHMEFLERAKEAKSNDQGEGPVRFDGKTVLVTGAGAGLGRAYAHMFGKLGANVVVNDFLEKNAAAVVDEIKKAGGKAAPAVGSVEDGEKIVKAAVDAFGSIHVIINNAGILRDKSFAAMSDQEWHAVLNTHLRGTYSVCHAAWPIFQQQKYGRIVNTTSAVGIYGNFGQANYSTAKAGIIGFTNTLGIEGKKYNILANTIAPNAGTAMTATIWPQEMVDAFKPDYVAPMVGYLASEANEDLTSSLFEVSGGWVAAVRWQRAGGHSFSHGKPPSPEKIVKKWSKITDYETNPSWPTSPSDSLGDIVSNFGQEEEDEDDDDEGGAGGDYSDPEDPEIVQKAKKEPIEDSEFSYGERDVILYNLGVGATEKDLDLVFEQDDDFRAVPTFGVIPQFMASGGIPLDWLPNFSPMMLLHGEQYLAIKKPIPTSATLVNKPKLMEVLDKGKAAAVTSVVHTFDKGSGDLVFESQSTVFIRGSGGFGGKKSGKDRGAASAANKPPSRKADKVVTEKTTDAQAALYRLSGDYNPLHIDPSFAQVGGFDKPILHGLCSFGISGKHIFREYGAYKDIKVRFTGHVFPGETLETSMWKEGNKVIFTTRVVERDTQALGAAAVTLADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPA3</accession>
    <name>W3VPA3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPA3"/>
    <dbReference type="HOGENOM" id="CLU_016513_1_0_1"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="8">
        <location>
            <begin position="49"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="193"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="311"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="70195" checksum="A5425E62F27D967C" modified="2014-03-19" version="1">MRAEEGFQFERFRVGSPWSSDAALRLTILRLLSTGPAALPASEIERLFDSLASFGDKVAGEYTDIGATLDGPQHEPTLIQYDAWGQRIDKLATGEGWKRLKQVSAREGIVAESYPSSDAKHGGGRDKIGPHARLFAFTRNVMFSPVSKVILCPISMSDGAVRVLELFGTDAQKREIIPRLTTTDASKAWTAGQWMTERPGGSDVSRTETTATPMQPNKAAEPGDKFVINGFKWFSSATDGDISLALARTDTDLSQGSKGLSLFLIKIRDDRTGKLNGIRVHRLKKKLGTKYLPTAELELDGCVGELVGPLGRGVATISSVLNITRLYSAGGAVGALSWGLRSATAYAKIRPALGGGKLDRLPLHTDQLLKVTVLYRVFLQIFFTNVLLMGASEAGTASRRDQTRLRLLTPALKAFVATRASEGYLTLLEAFGGQGYMEEVGMGEILRDATVERIWEGTPAILSLDVLRVLVQSNGQALHEFFEDTTAILTSLPAQLAAQLKHELGFLGSVIRETAGVLGKLDVQRHVKSADLRFTRYLLDLIMAVHASALLLQHTAWKASTFAQDSKLQQVAAVQIDEREIQHDVHLARLWIGGKDGAAGFADLTRLVAQLKAAASSDAKIAAQDVDLGHSLVYSWSQAQPQAKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPD1</accession>
    <name>W3VPD1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Exportin 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPD1"/>
    <dbReference type="HOGENOM" id="CLU_264369_0_0_1"/>
    <dbReference type="OrthoDB" id="5548448at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1272" mass="136872" checksum="70A3B978B05B041A" modified="2014-03-19" version="1">MSLVAPNAHLQEALASIHQASADFTSPDPQLRAKGEATFLALRQSEGALDYACFALEHSQDPLVLFQSLNAVLSVLPSLSAHQPSQGVASLTSLRDFLLHFCVTRSQQSSAAPSASSSSDGSATWPQYLRSRAFQTAIAVEKRLLGLELAQHVGQHSGTNSALDAVIDAHVGLLNTQLASLLSLPSPWPVDPTESAATLARIVTGLGLVRAVVDETILTSANDVFDSSSGSDRNRSQNAASASKPVAPGSSVGLNLLQHRQCKALIQNHVLAGLMTAVFQLLYNTISEDASTTESSSWRHPLFFQAVSTTEKLLGWTFTRFDPFSSDAWQQQSRSQQDDSVLATGVDEDDEQQSGTVTSQGKKALRPQYVSDAFVPVLLSDDVISLLTTAYRFGLRLQRNGVASRDISFSIHRLRQCILSTCSFIPQAQKPQHVPTLISRTKHICATLQSLVEEECASPSQLLSARGNAMLFLAQAFQIIFSVVPVQILAASLHQSGAGAQGCFSFISSLATLGKAIFGLAFHRPTDTDEEDDLAVLTEDTVDVLLQCWQTLTSTLRQHDAAHAQDIEVQVFARAVYGSIRDQVFAPYVTGRLEAASIVNGEDDVSEVEEVTAKDRDVYSDQLITIANLARTSVADNLRALHQLAQPLCEKLIAKSQRQSTLSDVELGQTWEQLHWLILIAGHLLADDARGETPEVPAEIAASAEPEDPAVALIMQLGMQLLQHLSAFGPASVEATSPQVTETLLWFTGRWTSSYLLIDERSGFATNAAIQRAFGDQAGRQTLTFLLQRLSENLQLWMTDSDVLLQLAQVLSAFTRSSGIMICLLQLAEMEQLVSGIVSGLDHLPANTHGALIASVVGCIYSGATHPEATTERSAEFYFKQITASIEARFGALLSRADFAAISQRSDVISAVQTSLDMLEGLASSIQPNSAEIVYGFISKFFAAFSQLCRVYDTRPEIAVSVLRVLHTLSVSLELDFGAEPFIVMGINQAVWELMQALQGENRAGKKKTHLLLASEAGSPLDDDVPYEGLCLLVELLTELSGSARAGVDDGGSDQAAELQPTKTSDVCLMGFEHVLGLLTTAEPLSVPRMRQALGKLTSAVFGLFSGRMILVASAAAGTGTHEPSLLDKAVQALSLCIKMDENETAQLGLESIVAFCKVVSVHFAPPSAQLVGALHGCLAAVLRLVLAEPLDSTLFWTALFALLSLIKVARATELGHAVGSAAQGLETSEAFQTAARELVESALGPLGHNDAEWIHEAKLKLPRWRAHIRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ53</accession>
    <name>W3VQ53_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ53"/>
    <dbReference type="HOGENOM" id="CLU_1548272_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="173" mass="18646" checksum="BC8206930D2C2F88" modified="2014-03-19" version="1">MFHKFLQSARVTVCYRRRYRPPSSEAMREAQQAGECSRQAEVVGAKPGSPVESELSLTLALEDRSSDDADSVADCSTQSLAVLDWELPELRFWLSGAHALQPVGSMRVGCHSGTFGFLGAKEREKREGAKHALGASVEHLTRMSSRAPTDGGTPSAHIVLEQSGPGSAHLRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ66</accession>
    <name>W3VQ66_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ66"/>
    <dbReference type="HOGENOM" id="CLU_399072_0_0_1"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833471" evidence="2">
        <location>
            <begin position="21"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="585" mass="63245" checksum="0BEB7D5764EE32C9" modified="2014-03-19" version="1">MGNLSGVVAVLAVLVRPSLVVPHVQVPDISHLDWSALHANGVRFVVFDKDNCLTAPHSDTIQPAIAAAWDDCQRVFGRENVLVVSNSSGSSDDPSGLGAESLSRALNVPVLCHKQKKPAKACAAEALEYFVALSHDRDTTLAQAQHMPPGSATIQAGPSSTTRRYLKERRKLISRGVPQDSEGRGSVLVVGDRTMTDVILAHRMNDELGRRRSRLAQQAAASDDAGSHQERVMGAQCVSVLTTGIWAYEGRLNALMRKLEARTTAYLISKGYRPGEPGMLSRRAPTSASVNWQSIAVSSSPTPGMVAFSSGDESKFAYTRDNVPAAVPSEPALGAVLVSALVRPLPRGLGSIISRLLASRPVVWLSSNLRDGWNVMMQGLAFGVSEAGISRGRKPLALDAEVAPRSKTQLKQQAVTASMAEYLDARVGAVSQLGRGGVQHMRQLGSRASILGRRQMEVKQVRPYSTGSGAGGRPRVPMRNWVAALSALVIVPASYYVGMRLHDLKETKAIDPTQPLPPTPAKPDAQLHQHPAPDMPSDPAVQKALRAAQADRKRELELTLFHLVRERQEVLDKLERVHQRRAELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ87</accession>
    <name>W3VQ87_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ87"/>
    <dbReference type="HOGENOM" id="CLU_031040_8_1_1"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="94"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="222" mass="23933" checksum="1229FE1721776799" modified="2014-03-19" version="1">MALARSSHQSVRLLHTISPVRKTLLGTSALVATAAVLSSNGYLPTQLSSAAAPFVQPITSSFRSFSSSIPAAFKMGSTASSQAAPESFPKGMSNSEWRTKLNPEQFRILREKGTEMAGTGKYNKHYPKDGVYTCAGCDSPLYKATTKFDSGCGWPAFFDAIPGAIDRHVDSSWGMERIEITCKSCGGHLGHVFKGEGFNTPTNERHCVNSVSINFDKDDAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ97</accession>
    <name>W3VQ97_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Initiator tRNA phosphoribosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ97"/>
    <dbReference type="HOGENOM" id="CLU_027654_1_1_1"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="108"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="391"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="56595" checksum="4B85999814CC9E85" modified="2014-03-19" version="1">MTSTEPADTSATSAASAKRAACSQWTHSDRIKRESRHIFNKLHSIAADADFVRRVHYRYASLLVTANLRCGAWYTDPAITSAVSYFKSTDGHTHQWSFSLKRSNLHVSMPDALSKTIPVWCAVLNTASQRKYGVPTSESEAFGLHTPTWMIPPSEHDQIRARIDGFVTALLNSDLDVPRLDKPLQPIFVTPQNDMDMLPSSLANTTATEIVPIVLLSASRFISDSASLDSNTPGGAETGGNSFVYVQGAGDDHENWARGLTPDLFWQHSDALLACEKDLLEEAVDNLVKHHSTASGSRAHWFTPRAVGSEPSDGADAANRLAGTAQGDVEVGNTGIFIGARTAEHNFSPDERALYTRIIHFTSLAPPAVPSNLSFNLEALKISDSEPSSNVYPIHMSPNKKGLLAIRTAFPPAITCAYRTLIDPASAVGSRPKILVSCQDGKDLSGSLVVAILASCFTDTRQLITADESKREHELALTKDTTRRRLQWLVSASPRAAPSRAFLLRVNELLLSHKHKPAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQD7</accession>
    <name>W3VQD7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQD7"/>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_1"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="226" mass="24728" checksum="61DA12265415655A" modified="2014-03-19" version="1">MASFLTRGKKIVAIGRNYAAHAKELNNAVPTEPFFFLKPTTSYIANNGTVEIPKGIVAHYEVELGVVIGSARVRDVSAAEAMQHVAGYTLSIDMTARNLQDKVKSKGLPWSSAKGFDTFTPTTGFIDKSRVRDPSQLKLWLKVNDELRQNGPTSDMIFGIPELIEHVSSIMTLEEGDLLLTGTPQGVGEVKHGDTMYCGLEDQSGNLLEQLKINVANRVGGYEFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQG3</accession>
    <name>W3VQG3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FYV7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQG3"/>
    <dbReference type="HOGENOM" id="CLU_1240610_0_0_1"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="219" mass="24094" checksum="710D91B14717B50E" modified="2014-03-19" version="1">MAPPKLSKKQLVKHRTSATPSNGKKTGGFQVGPKHLPDGAYLGKHKRIKAELIHKAKVKKEYYKQLKQDKVKPGSSGTDANAAPLGERGSAAGSAELESALPFSLPKDQGRFAPENGDDDAQQSDLALFGAKQDLRPKRAPQGKGKKPLPHPLPKPAARRDDEERVRDTRTKEEKEQERLKQNKLWNKPSGSRTGQARGQPNLSARMDVMLDKIRKSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQG6</accession>
    <name>W3VQG6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQG6"/>
    <dbReference type="HOGENOM" id="CLU_336523_0_0_1"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000071">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="45"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="186"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="847" mass="91549" checksum="AC8822EC93B97666" modified="2014-03-19" version="1">MSLLKAFGQALQRSVEVARDETAKMMRMEISPTSKNQGALLIYAMTQPAHLSNFATGSDSDIGGLSQCRLGLDESSRGRFYGTLSSQVPRGGKIEKSGYAGFRNRNRPTLFGNQCWDTTVHPYLALRVRNRLAKKPIAGADKSEHADAGAGSGLRAALHASGPSGPATSRAVHALGLGRKELPGPKFFVNIQTDGPVTSDLFQHRLYLDESKGSNWQTVIIPFNDFVLTNTGQVSNSQVSMMREKIRTVGISSVLDVPVPPSASKPPSKDAPPSALSRNARESEQEEDDWAVDGDLRADDNLDTALRGSKRGATFNFDLGVESVYASPMRGEKALRGASIRGSLFGFPATMIPIRDGLTPGISSRLPVAPLHICGLEESREQWGKADRCGGNWRGGKNNTTRSSLLTANMALDPFEPIVFGAEGAELVATVLPYGLTIHTIGTEEGEDFIGGPEHPRDHQTRGRAFLNPIIGRFANRLPVGKIDYTSASGHSGHLQLEEYRGPGVVLHGGAEGEKENQVDSIVQHGPFDRCYWQPIDTKDSKFFSDAGYASTSNPRGKQSSLIFAIESPDGDSGFPGQLRVETLLALVPGSGSDSVMGKSAGKLLIRYRAALASDGSVEATPFNMTHHWGFNMSALNEQACKAENGTVTEQIIQMYPPPGKPLYHLDIDPAMLATGKMNVTTGEPETFSNPGSHHWDRKDGKRISDGMPANGYDDFYVWGPDASVPQADEIGQIATEATKRMRVTSESAGRSVLFYSNQVGVQMYTAEGQPEHPADPAKSGGLMKQAHRKGGQPDSGNFKRSFTAIEFGGPHCGFLHDRLADMGGREEVLEKGQIYDNWVVCEAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQW2</accession>
    <name>W3VQW2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQW2"/>
    <dbReference type="HOGENOM" id="CLU_037639_1_1_1"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="184"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="383" mass="40398" checksum="077478D5717219C7" modified="2014-03-19" version="1">MAEAKLTKKQQKAAQFKAGKKGKAAAIADHPATPDDVVDPDDAPSTSAAVTSTKEETKVPSKKKEKESKNKAKEFVAEPSAAAEAAPVEAPVKEEKRNKKRKRLAAEAEAAAAAGIVPEPTPSSSTKASKSELKPKAKATKIAAPAAPATKTTFGDDGEVASEQAVAAVAEATPSAASAKGSKFILFVGNMAFTTTTDNIAKHFGQTCGEVPTVRLLTRKADPNALANLPASKRKSIAKGKAQDPTQPQSKGCAFVEFKSSDALRKALNFHHTMLEGRKINVELTAGGGGKSENRQNKIKEKNAGLEKERQKLHGKYVAPKNEARKQRAGAKEEGDARPAKRSRTEDAEQGGQAAWSRNSGKERKMPKFMATGANAVRVAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQX2</accession>
    <name>W3VQX2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UV-endonuclease UvdE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQX2"/>
    <dbReference type="HOGENOM" id="CLU_376520_0_0_1"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000012">
        <property type="entry name" value="Related to UV-endonuclease UVE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="656"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="731"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="84506" checksum="CC1B2DCC7993E679" modified="2014-03-19" version="1">MIRRYCWQTAFQSLPYTPSASIVRRSVPPACLHLDMVRRSARASTTAVSYADAGSSSDDAAASELAPPPSRATKAVKVPPKKAARVRSSQTAVTATSKPTPRARSTKKEATPSPSPDSAAGSPELGPADGKSEDARPARKKRGEGAAKKEKVETPTHFETRVNVHGEEYQIELDEEGDPVRRDKNGRRLAKRKKKDIIYDIPDVPKRNFSLEGPPEKRQERSNGFIGRLGYACLNTVLRWQDPPIFSSRTARIKTMDEQGPDYIKELGRLNARDMIPMILWNEENNIKFMRLSSEVFPFASHEKYGYSLKYAEKELRAAGDLAKKLGHRLTMHPGQFTQLGSNRPEVIEASIRDLTSHCEMLDLMGMGKDSVMIIHGGGTFGDREATLQRMHDTYTTRLSQNVKDRLVLENDEMAWSAEELLPLCKELDIPMVFDFHHDLLRPSSRPPSELLPEIQAIWHKKGITPKYHLSEPRPGSTNLRERRAHSDRCGFLPPDLPADAHLMIEAKDKEQAVLELYRIYDLQPVKHDSLRPPAKDIGVKTSGRKSKLGGERLPREPKKGKVKDEEAAAEPVQLNPKSLSKAERAIAKSKEVAKRLGKVYTGPGADVGEDEGIELAAPEPRPGEEGYVKTSEEVLDDMHMEAAWVRAELQAGRERRPFGTEPGAAVDEADVDGDDVDEDGVANGKIDAKPKKANGKAKGAEAAVALTPQQKKRAKAAMVDDGQRVVLAQGAPSKELVEDHEQIPVASATQPKAGTKRGRKASASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQY9</accession>
    <name>W3VQY9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQY9"/>
    <dbReference type="HOGENOM" id="CLU_306991_0_0_1"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="932" mass="102646" checksum="0B3FD891FBCF4C07" modified="2014-03-19" version="1">MERVQYQLERSIPQLQLLDEHAVFTKEQLRSITTQRQTFEARLLRRGPEKLDFLRYAQFERNLADLINVKANRIGLPRSFHRDNAAAHTGHIVAIYERMVLKFKYDIDAWQQYIAFAKSRKMRVVTGRVYARALALHPNNVPLWLAAAAHELNDNASTTAARSLLQRALRLNRLPWKRSEVDSASSANGKRTAADSAPDSSKRVRTDSSSAQNGNGASDSGPAALKVSDREADLLRLWVEYIRMELVFIERLRRRWLVLGLEWESQGGHDDAAASSSNDTAEAQQAALDLDTDIATANTANSDELDADQERILLSQVPENDADAAATAEDADAATGAKPNTFTPRKMTTIPPAQIGILRGSIPLYLIGSALESLAPHLHFVLLVALLDVLQTFPFAEPLSLDAPKSGEALRRRLLDQVYTHLSDRQRWGWQHFAPVALVAALRSFRPDTTAGADQDERTAAHVANTEEMESHRLLTSASHLRTTFSNEIDGLLELASQLRSGSAAARRAPVSASGSSSTLAVQLVLQLLQSLLTVTAGSGSRPSASYDALAASGLLPVAVSDAVKQMRSWCAEAPVDVSVRKGPSAKADFYTTTSLLLEMLADSQRSAIDEPNLVQYLDSVQTQLIVEARGAGAGVETAQMRAVSVRRQLDTALAIESDKERSKKLGKLQTQIKQATTGEFGASDELWSLRILVATQLAKTSGAEVEHSRDAIGAEWRRGLQACAGADGSTGAAESSLWARYLEWLYRGIAEAPHKKKAAFKYSSEQFRWAVRETASLLSRSSSGSVEALQHYRQELHDLCVSRYLGLSREVGKVEETLAWLLQSSFASHHAWISIASQLGEDGEDKLVRRVFGKLLQTQPDQVEIWTAYLRYLAVDDMTEALKTLESCKTTVGKAEYKLVEREWHSICQDLEKTTQNDINDAAGTAESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRE5</accession>
    <name>W3VRE5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRE5"/>
    <dbReference type="HOGENOM" id="CLU_028981_0_1_1"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="250"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="482" mass="54340" checksum="F10110D972D4F773" modified="2014-03-19" version="1">MSDDEFIMDDAADEDYDFEYEEDDDLEDADADIENMYYNAKNIKDHDPDGAIRELKAVVDAEKEKGDWGFKALKQQTKINFHRGRHAEALDSYTRLLSYTKSAVTRNYSEKSINNILDYVSNATDVGLAEMQSFYDVTKSALEDAKNERLSVKTDLKLARIWLARKEWNRLAKSLKELRAYCTGHDGTDDQSKGTILLEVFALEIQMYGEVGNFKKLKEVYNSTLQVKSAIPHPRIMGVIRECGGKMHMSEKNWAAAQVDFFQAFLNYDEAGSTQRVQVLKYLVLAHMLMGSDINPFDSQETKPYKNDPEIVAMTNLVSAYQRREVHEAEKILRENKRTILDDPFIKAYIDDVLRGLRTQYLIDTIRPYSRIQLGYLAQQLNISVDKVENLLISLILDESIKARIDQVGQYVELDRSATSSSKPRYQALDRWKSELDRAGASVHGKHAGGAASGSGASVGGSFLRMGVGMGGMAASLGPSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRN1</accession>
    <name>W3VRN1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRN1"/>
    <dbReference type="HOGENOM" id="CLU_102617_3_0_1"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2440">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="82" mass="8466" checksum="1AF448ACB1A1E86D" modified="2014-03-19" version="1">MSDAGRQDFTDKASSALKPDSQKGVGEKAKEGLDKAAATLQPDSTKSNSQKLGDKVSGSDKSDESILDKAKNAVGLGNNNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS06</accession>
    <name>W3VS06_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS06"/>
    <dbReference type="HOGENOM" id="CLU_008220_0_0_1"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="875"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="58"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="553"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="936" mass="104779" checksum="B901FBED7CFD4AD0" modified="2014-03-19" version="1">MLGFLRKTGRKLSESAPSMTEDGKSLGSDYNEKDHSGMSISSSNPAAKDENWIDARDGYRVMASHLWKSCSKRNFFSENPEVASGVAIRFAKGQYVVCPAQDERLAHFCRSVAILNCEAAMTITSPVVSAINTRLAPGTMQIPITPSQHVQVVDTMEQLAGARKAQNACFIRRENTVVIWCDNVEQIEEQAQDLEQKMIMFIWRSSYSNNTSNIIASATSASIVDASMSQFNQNQAKFRSQSGTGHATPIYGAKAGSDSDSFAASNPFSGTGSPDDLSRPSSFHDEEKGDPEKQGASITEERPVNYQAPLMIGLAIGLDVVLCFFFVSKLFQFSLLDGNWSRMGLAAAAPLMFPVIMFFSSSIINAIFQILGPVRQLHQNSRFYSGKAPKRIIGQLPHITIQMPVYKESLEGVLIPTIESVKKAISTYELQGGTASIIVSEDGMQLVSSAEQAIRHEFYEKNSIGWVARPGHGQEGYLRKGRFKKASNLNFTCRLSLAVEKAMMEHRPQTPQGLALWTEADEVSLYERCLTQCLPELHPLAQAKGNIRFGEFVLLIDSDTRVPEDCLLDAASEMVQSPEVGVLQHCSGVMLVSDSYFEAGMSFFTRLVNFLISFMVAAGDVAPFMGHNAFLRWSAIQEVAFVDPEDGISKIWSEAHVSEDFDMALRLIQSGYITRWATYSNNKFEEGVSLTCDDELNRWQKYAFGCAELVFNRIWEWPYRGPFTKLFRSFLWGSAPMHYKFSACSYIFSYYAIACGFPLCLGLYLAHGWFYPVLLPAYMPSFNIWVSVVLVFTCAGNVAQIIGRYRAKADTLFNLIKEHLVWIPFMFIFFGGLSLHILMALLAHHLGINMTWSATVKDLEDSNFFIEVPIIFKRFWKVLLLCFATLGGIVVLRLPNVLPLQWQIQEFFTYWPLLLTALLHVLYPIALNPALLRFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS53</accession>
    <name>W3VS53_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low temperature requirement protein a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS53"/>
    <dbReference type="HOGENOM" id="CLU_022899_0_0_1"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="609" mass="66688" checksum="BE84153713228686" modified="2014-03-19" version="1">MSTEHRGSVASTGSAAPTGSLAAAEHAHQAHHLKYGNVVAAGFYPDDSGDEDEGEEQEGAQAQEADAATSDTLSLAPSTSSGTSNGKLPRDAKARKWRSLERREAHSRAMHEQRRYLFRRPRALQYFRGNVLVRSNEERSSHRLELFFDLVFVGLIATLAEEAVHEHNGDAIVRYILTYTAAWMVWNYMREIFNAFFVDDLPQRVLVLAVMACLVVYGNNAPSAEELLEESGARATAIGSYLVAVGLIFGLLMFYSFYICQYRIQIRSQATIWILLVGLWIGSIFVSVRACIALVAVALVLEYASWMFFYSPLFKRLAKLRYSSAVAIEHEIDRFTDFVTLVHGEFLYSVLSGHPAGTGVHSGVARVVLTTIVAFVLHGIYCTGAGSKRITHPIRRSMSYAIPFFGLHLPLVSAITLCGDATAELVKENEVAQGIRWIYSATYAIGMISTALLVMLEKELDAPGELFFSKPVRIAPRFVAAIVVLLLPLADQHHINSTALLGISAALGGAAWLWQELGSLDGPNAPWHQQSSSFAGVPEGAQPHEHCTRTWTGFPALVEPGAWNLDSRRQRGRTTTFVQESNPADISPSAEAIAASPCHEADSPKLATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS84</accession>
    <name>W3VS84_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS84"/>
    <dbReference type="HOGENOM" id="CLU_348577_0_0_1"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="92"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="775" mass="85676" checksum="B9A3319160BCD7AE" modified="2014-03-19" version="1">MVSLEPSAAAAGLPSLSAPATMLPAPLQPRIPRGPARIIVLCDGTAQARNWVKTKLTTPKDDPDAADDWDRGDKSDKPRKTDADDKDDSDAQSGDFFTNVALLAKIIAQSSGNTPSSPPTSPHPNRSGTETKGAHASNAMPQIVFYQSGVGTGTGALQNLFDQGTGLSLGSKIEEAYGFIVDNYQPGDELFLFGFSRGAYTARCINGFINWCGILSKVEMTHFADIWAAYQHRDADKIRTETQAAEVLYTATLRYPSAESEALATSMYLWNLYHLPENKNMPEAKRQQLIAKRRDECSKRRQKMLVVPPQIKAIGVWDTVSALGLPGMFQDREMIDFFDFYDPGLGSNVQFGFHALSLEEDRKDFLPTMWYQPPPAAAGLTSAQGEFGVRGQFMRSKQVLKQCWFQGVHTDCGGGYQFHGLSDITLIWMVSQLVDKHILPDGTETLGPLLNIDLGLLATILDRRREWAMQLPHHSRPTVNYQQARTVNQLEYHSSTMRRSVWASMGESGRTNESIHPSVVRGGRIHPDTHPAFAEVRRCKPEKLREMWDEASDWEGSLRPTEKMLYWPARAPYPWIPGADCAMNPLISPLVVTGGWNIPELATHRARQLMIQAASQRAAAMADVDDDEHLPSRDAGVDVDDQPTDGWDEPSAAQPNSGAVPSITGLVPLPRVDYPEIPAKELGENPVDASRHPRLHTLWQKTYNASAWPNALFVDVLNLAAVPTANLRQTAVQGWLWQLGDKVAGYADDVKTQAIQAAMPDAPRMAKRKLKQNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSD1</accession>
    <name>W3VSD1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSD1"/>
    <dbReference type="HOGENOM" id="CLU_483217_0_0_1"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="358"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="564" mass="60997" checksum="C7D074CFC63AD7F9" modified="2014-03-19" version="1">MSSCQTAALVRRHGQPSLREAAASLGRTLPLPSSCRPDAAYLRLQTCDSLAGPRVPSRIPPKRPSFPFSLFPSCFPPETVFPLDPSHSPFIFRRLAKPPSSDSNAGMLRPLPLGPCASQKPLLAGGDDQRSLLSARPAFDRDASSRHQSPSHSLILQSCCFDTRQRAARLHLNVCSAATGPFNMSLGERDQASGSQARHPRQARHPRADTSAHDAVASSTPPATAERIHTRRSDREIRPDDIDDQKMSFSGSKQPSLRGHAHQSPSITVESLTTASLKASDAAPHRVETLAGELAPESAQNSSSHRAGKGLSPSSRSTQSQTPRAGSSASSSTIAGLQDLRTGPSAPPPMLTGLPQHSIKERTYKLIIRQQPQQGRLCGLGSKDKRPLDPLPILQLRILRRDGTEDEDAENSPNLIVQVSLCKQDMATGTHAESVLVESNAAAHPFTRMLEGRLVASANVARDLDGSRACFFVFTDLSIRQEGHFRLTFKLIALGPGDPSSPGGQVLAEALTEPFAIYSPRRFPGMTESTELAKCLARQGIQVPVRNDVRRRQEQADSDERDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSS3</accession>
    <name>W3VSS3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSS3"/>
    <dbReference type="HOGENOM" id="CLU_010194_12_0_1"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="299" mass="31377" checksum="0C134EED2E196FB7" modified="2014-03-19" version="1">MSLQAGSLFDLRGAIALVTGGGTGLGLTAALALASNGAKVYISGRRQQRLDEAVAEYNPTLQSGKLVAVQGDVSSKEDLGRIASLIEKEEGKLHILVNNAGIEGPMTKFPAPSSLSAADLSSAHLASESFEEWDKLFRINTSSIFFSTMTFLPLLSASHSHPLSASTQQGKWTASVINITSISGIVKTSQFHYAYNASKAAANHLTQMLAHELRFNSNTAIRVNALAPGLFSSEMTSGGKSDKGKTNPNDVTGHNNPAGRVGSESEYAQLVLLLAANQFITGQIVAVDGGFISAVPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSW5</accession>
    <name>W3VSW5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSW5"/>
    <dbReference type="HOGENOM" id="CLU_581556_0_0_1"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="213"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="516" mass="54223" checksum="283D552CA8DE5BB4" modified="2014-03-19" version="1">MSSLGTDQSSKGIELLSIADAVATQEYHGETVGLGAGKLQALLVSIELHDAAQRSPSASTKQPDYSTDLWLVLSIGDDFSLPIAATQTIVPQRTATQTSYELPSPELEGASIKIKLPPTTSSSDITRFQQILSQYAAYQDDDRSDAGMIELMDEDGKVLGVMQGNFTVREAAAMSDSGNEKAPVLIDLPPEPTSDSEKQDLDVDVLSADEKRDWMIRGADVISRTIIKTSEFVGGKIQGAADSYMAKNPAAGSSGTTTPNNEKVDDGKAQVAGKDPVRVGPKTQASVRQLHQWSGQAVQVSSKTTGAILRVAGNVGDKIGQKTGIQRKVHADGTYGPAPTGIRGFINRSLIAANTVLDGIDAGAQTLLYTSGEAASNVVGHKYGEDARQVAEGISRTGKNVFIVYKDIRGVRRSALLKAARSRVMKAKLDDGREVTVRIDEKGNAVADAVSPAPGSSSTTAEKATASISDKSSYTTASSTPTHAADPPSYSTTSAGSTLPPPPSHPSTRRSPSPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSX0</accession>
    <name>W3VSX0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSX0"/>
    <dbReference type="HOGENOM" id="CLU_483218_0_0_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF242">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="330"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="564" mass="63256" checksum="177DFEC51B9E0C22" modified="2014-03-19" version="1">MGAICTSSAYRFPHLLGKVDPSRWAGARLLLRFRQQEIAGLVCGGNLKASVGCCFRWKSAVERNKAVRPVSEKSSGRDGAEFAVIGLQTTQNSTQQRQQQRSSLCTGSNQLFPAICSWPDAGRRSLANGPDHDRQQRWILIQLRPLLRTQRQRRCQVPVVTTHPLFRPAKAPIVGRDTARSEQATLARAGRRDGLSKEHVRRRQTIVRPVSFQQFEPPKIRGRYPDGYGSAAAASTQSAQQPSVQEERGLPYPLSGIFSPWYWLLKLAATFFRGVTYLKRGTERYLRNLPPLAGIARERLQVPSRDKGRFIGVDLYRPADAPATAKLPVIVNWHGSGWLIPSWGEDREFVNQAVKALRCIVLDCNYRKGPEYPYPAAHDDADDVVEWVLSQSERFDLDKVALSGFSAGAAMALSTSNAYSGKISALSALYPPIDMCKSEMPPKPTRQPRSGVYLAPRVVKLFNDCYVPDLEARSDPRLVIAGLDTARFPDNIFIATGDIDLLHKNDKEYFEKLAATHKNKTVKFVSVPEEEHGWDKNPLVPESLEARDNVYRQMFDNISQAWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT77</accession>
    <name>W3VT77_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT77"/>
    <dbReference type="HOGENOM" id="CLU_013963_0_0_1"/>
    <dbReference type="OrthoDB" id="2556536at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="708"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="935" mass="98914" checksum="79474BDCEE2C211C" modified="2014-03-19" version="1">MAPPATEPNLGAISPLHRPTLMQTSACRLLRALTAATMQTVIHAVTCPLLLATHPQQVHSAVQPSVRCRMQHVDCTASPARPRCFFRALQRLEVQIAWARMKHTSIRPSYHFGPLPKSEPPSPSSGAARVASDEPATDSQVESYFFTTVQRLKPALFRNQSNTAAKPAELLPTRPGLSICLTVAQELDSWLHRRLDLAGVTFPLRPLALGLWKTTSPHRRFKPAIRIDFGIFQRPSKSRVPTLVSDPTRLSSQVLSSEDISSVAMTRDSKAALRQSGRRRAAGVVAMLAVATAVTTATFADASTLPSNLWGKRQDPSMLSQVEAQVLKLISADGSFATMTGANANAIQSAVGMSGDVTPAVVSALSSATAASAAATDAASTAQTPSAIVQAVEATAAPTDKVASDTLSSAQESQLEGEVGAVAGDSTADGGVQSWTYDPGAFGCLGSDASGDAAATLCSVNAPAPAATGARSEQALDSVGDSAFEPVNAAPTPMRRNAVRAAPTPEPRLDGDLSRRQYPIDPAGPAYTSLLVSSNLFPLFTSYVTLEPPSTTRVNFGPTSNLNVSSIPRRGSSDSGNGEAPGNINNPNSPDLGWLDVQIGGVPYKNGDLIASIVWILATIALIPLLLIRLLRRSSLISMVLITIIVFMVLMLIGFGVRAKLANNTPTTSMMNVEGIILAVLLPLLLEPLLHLLGLYSKQGGRPSGVPTASLVLRILNFIVFLLFLVAAAYYASWLDKWENALKMTQTAQDLPDIIPPKVTRIAPVVGAIIEIIVILGAALLIPVARGDAGSLRPGGFIFILLILLFVATVYRLLQALHATTRISAEQGGSLDANDLLPFFQGGSSNTTTDNQRVANGLSLAPQGMYGPNSEGIDWEQLQLTMASRGTPQTPLIFNLVYVLPMWLMVFLLFFTHAPAAKKTEEAAGGEGNVAVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTH5</accession>
    <name>W3VTH5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTH5"/>
    <dbReference type="HOGENOM" id="CLU_1939048_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="130" mass="13675" checksum="FBC95783F0CBA889" modified="2014-03-19" version="1">MTQRAACCPRSSSAGPTRPEGAPTLARQQPPFGPPLPGSAASNAVQIQRDTSNARASVDGVESSALLSELNSERQYFGYQERGEGQTGPELLADLLGRRATDAIDNARPVRRSASLSAAQFANPSPTPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTL8</accession>
    <name>W3VTL8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTL8"/>
    <dbReference type="HOGENOM" id="CLU_1468793_0_0_1"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="184" mass="20106" checksum="B53E96C284DE4C75" modified="2014-03-19" version="1">MLLAKKLLGPCLHLAGVLLHLGTSTSNLHAFILKLIRASTLKQSLPAASVITSAGLPWNAGIRLCTFFLGQHSSVASLERRTKLTAPMAASSSKDELDREHPNPCYPRACAIQSCLQKSGFDQARCEHLIDDLYRCCAKFYRQRGTDAEADSCPIPSVVDRRIRRMEQEGKGGAGGSLLETKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUK8</accession>
    <name>W3VUK8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUK8"/>
    <dbReference type="HOGENOM" id="CLU_394316_0_0_1"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="8">
        <location>
            <begin position="178"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="662"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="699" mass="76812" checksum="6E686D00245B3B40" modified="2014-03-19" version="1">MPQKEIIHLSFGSIANHISTHFWNQQQSYFTYDQVDDAHAGPSGSTSRSTDEDEPLVDHDVSFQAGQTLSGHDTYNPRAVIFEIEQEFGALAKLNALYDSFPPDSTDRNVALDSLQSWGAEAQVIASQRIRKSAYQRRLELEDQGIDPGSSDDEAEARGADGEHAAATPPQAKQRRKQSRMHRFWSDYSRTYFHAKSLVSVGGELTAPMLGSYNSAESPEANDGRVRFETFSQGAAHFDELEKRSEVLDTNLRWFAEDADLLQGFQYTIGTSDAFGGLGAKYLENLVDEFPKITHLVFGSAWGNTTLIQDDQDGADAAWQNRLARIRKMNNLLSLVQLMEYSSALAPVCVPHGDQTTQVGADWQRYLGRMHLDDMHHASALLSAHIETATLGTRLRSRTETLGSLVSRLNWRRDTKLVHLGGVLPVPYPVPLSSSSLKPTSSSADPVDALLHSYGYGDRDSRQRQRGAPLESQSQLAARGAQLALSSWIDLSLPPSLSGGASRRKELLYNLQRPFSHHAVLRNSNLDDAVLGLGMLDSLLAQIREPFGQGVYVPQSYNILSSFPNVFTHLDAQGKPIPRAQNAVANPAAEGSARVPRPKHAAMLSSLGATPSTIYLLRDARNTLSEALGGHAPLAAYGLDAEDAKDNLKEIREQVEGWIDTYSVDNDANSADNDDQGGMGTDEEYDVDHNPDDGLDWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUL0</accession>
    <name>W3VUL0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="14">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_00969</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="14">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUL0"/>
    <dbReference type="HOGENOM" id="CLU_003041_26_5_1"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="81"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="271"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="505"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS64507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="568" mass="62622" checksum="4FDB46929E442E8D" modified="2014-03-19" version="1">MAPPKDPEIDAEAELASQLAADVAAAESSTKAKAAASSSSSSSTPAAERQPFSTLDLSEPTRKAIDTMGFKTMTEVQARCIPPLMAGKDVLGAAQTGSGKTLSFLIPAIEMLHRLKFKPRNGTGAIIISPTRELALQIFGVAKELMAHHHQTFGIIMGGANRRAEADKLQKGVNLIVATPGRLLDHLQNTKGFVFSNLKALCIDEADRILEIGFEDEMRQIVNILPNDNRQSMLFSATQTTKVQDLARISLRPGPLYINVHADLAASTVSRLEQGYVVCESDRRFLLLFTFLKKNAGKKIIVFMSSCNSVKYHSDLLNFIDVPVLDLHGKQKQQKRTNTFFEYCNAPSGTLLCTDVAARGLDIPSVDWIIQFDPPDDPRDYIHRVGRTARAGNAGKSLLFLLPSELGFLRFLKVAKVPLNEYTFPSDKVANVQGQLEKLIAKNYYLHQSARDGYRSYLQAYGSYSLKRIFDIHKLDLAKVAKAYGFSVPPKVNITIGTSLKAKDSGSKRKEVDAEGGEDDGDINPKRQQSDRRAYYRRNHQNGSGSKDHFRKSGANATRSSGSKQWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUU2</accession>
    <name>W3VUU2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endo-1,4-beta-xylanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUU2"/>
    <dbReference type="HOGENOM" id="CLU_009397_4_0_1"/>
    <dbReference type="OrthoDB" id="3879658at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45492" checksum="A2FE756B292566A6" modified="2014-03-19" version="1">MNAMAPFRAADVTAGSYSQCNEIPSSCRPATIRTLLVQITVQSLTAMPAHPHLGYINPVIGHDFADPGVFFDRASQTWYAFGTNGNGKNIQCSYTKDFCCWEHHEHDCLPGPLPSYQSGTPGFLWAPEVIEAPQGRGGYLMYVSCQDAVHKKQCIGVAYSDRDPKGPYRWITDRPLISRGESGGTLDPQPFEDPASGKRYLVYKSDWDRMYTEHPQLWLSELAPDGLSLVGDMHPLQGPKHGYQCGLLEAPYLFHHAPSNAYILFFSSGTFTNGTYATSYAISHNGLFGPYTCPGHPLLQTDRHRSIMGPGGACVVRGVENEHFIVFHALEKQEGNRRMCIQRIEFNQDGTPVLSSRPNCGKRLRLGAEQDDDVQHFGNHQPPPPHEQGSGHTGSGKMSKFLRKIQDKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV41</accession>
    <name>W3VV41_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain amino acid aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV41"/>
    <dbReference type="HOGENOM" id="CLU_031922_1_0_1"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000014">
        <property type="entry name" value="Branched-chain amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43427" checksum="82BF024D98D9CD0D" modified="2014-03-19" version="1">MSSSNGRIATAPSQSVDWARLGFKERDVNGLVRVTWKDGQWGSIEIQKESHINVHAAAPCLNYGQQAFEGIKAFRSATGSVRVFRPQENWVRMNLSARMASMPELPQEVFLEAIKVAVAMNLEYVPPYQKNASGGALYIRPLLLATGPNLLLGSPDEFTFLVWVTPVGSLYGSGAEIPAVDGFVLDTFDRTAPMGTGHTKLGGNYAPVFAPTAAAKKQGYAITLHLDSATHTYVDEFSTSNALAVQKQGTETTLVVPESTSILRSVTKLSVVEIAEKLCGWKVELRQVAFDELKQNRFGELMAAGTAAGITPVRSLSYNSHKPQLQHEKLSPEGPKYTLPAENEVERIEFGDGKTAGECARRLFDELTSYQCGDQEDKFGWLWPAEGLVAEDANLPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV43</accession>
    <name>W3VV43_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV43"/>
    <dbReference type="HOGENOM" id="CLU_043857_5_2_1"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="6">
        <location>
            <begin position="35"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="134" mass="14599" checksum="9C176003CDF19536" modified="2014-03-19" version="1">MTSSSSPTAPSLSTSSTSTSSSPPPALEWLPHSTPRYACADCGAHLALQDELISKSFSGRDGKAYLFASTINTALGAQEERHLLTGMHTVCDLSCRGCGRTLGWFYLKAWEASQKYKEGKWIMEKASLHKINAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWA7</accession>
    <name>W3VWA7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mfs quinate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00575</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWA7"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="21"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS65117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="551" mass="60535" checksum="57C0241FC5D1BB5A" modified="2014-03-19" version="1">MLLSHLRDTPREARGWRLWFSAWAVGALGISRGLDEGIISGVLKQHSFIKTFGFDDNSPQEATIASQLQLGSVAGSAIAFFLCDRLGRLRTSMLACLLWLFGTAIWMTSAGVNGTHSPGNYQQLLAGRFIAGLGVGFTPVVAPVYLAEIAPKAIRGLTVCIFSGSVYIGILLGYWSNLGTSIHYDDARQWTIPASINFIFAGLTFIACIFAKESPRWLIKQGRYEEGRKTLSYLRNLDEDHPYIVNEVEVMEQQIIAEKEALEGLSIFQILKKLVTNKNNQYILFLGLGIQVLGQMSGGGVYTVFAPKIFGLLGVPGGQRTKLLTTGIFGIVKLLSSLAAAFFLVDMLGRKTAVTTGLLLQSVCSLYLALFLKFTSGVTKANETHSDKSAATGAIFFFYLSGLAWAIGVNSVQYLTQTEMFDITVRALGVAIVSLVHFAMQYAATRSLNPMLHAWGNFGTFLFYAMIALTGCLFVFFFMPETAGMQLEDIHQLFEKPWYRIGWTANRPANRKSASSAKVEADESQDGADLAYSAQLGQKKSIEEEEDEKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWE4</accession>
    <name>W3VWE4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="802"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1256"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1286"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1324"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1368"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1394"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1427"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1524"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="176"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="892"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1561"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1561"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1581"/>
            <end position="1592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS65096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1613" mass="177641" checksum="96C399EC0056716D" modified="2014-03-19" version="1">MEADGHASQPAPAIAAAAVSERDSHGTGTGAATTTNAATTNAATSVAGDADNSSHDSSSNQPSPAMPPIQRTKSGRGSVPFASLDPEGTAELTRRLTEHSLRARTRTTDGGEAALGFDPFDKNGNFELERFLRHVMDQAQGANLESRQMGLVWQNLTVTGLGTGYAIGDTIGSLPLKPFEAIKNFKSILHPPVKTIIDNFEGCVKPGEMLLVLGRPGAGCTSFLKSIASYRDGFRSIDGTLLYQGMDHTVIDKRLRGDVVYCPEDDVHFPTLTVWQTLAFAVATRAPQARRRLDLLESQDTNTRQGYVKTVVEVLATILGLRHTYNTKVGNDFIRGVSGGERKRVSVAETFAARAKIALFDNSSRGLDSSTALEFVKSLRISTDISNTTTIASIYQAGEGLTQLFDKVLVINEGKQVYFGPTADAADYFTEMGYVPHDRQTTADYLVACTDVLGRKTREDFEDRAPRTADEMARYWQNSPQGKKNHEEVEAYLKELRESVDDEAIKHYKQVAREEKAKHSRKGSAYIISLPMQIRLAIKRRAQIIWGDLATQLVITLASIFQALITGSVFYQMPKNTSGFFSRGGVLFFALLYNSFTALSEITAGYAQRPIVIRQRRFAMVHPFSDAIANTLLDIPIRTFTLIFFDILIYFMTGLAYTADQFFVFFGVTALISFTMVAFFRCLAAATKSESLATMIGGLAVIDLALYAGYVIPRPSMVVWWKWLSYCNPVAFAFEILLTNEFRRLNVPCGNYVPYGPAYANVPSANKVCPVASARPGQETINGSEYLAASFQYYYSNSGRNAGIVIAFWIFFLMIYFVASEFQSDPTASGGVMVFKRGSAPKQVVQAAKASGDVEAGDVAGVSPDPVADDANADHQDSNDAVAKLESSTSVFAWKNVNYDVMIKGNPRRLLNNVSGFVAPGKMTALMGESGAGKTTLLNVLAQRTDTGVVKGVFSVNGAPLPKSFQSSTGYCQQQDVHLATQTVREALQFSALLRQPRETPREEKLAYVENVIKMLEMESWAEALKLAYVENVIKMLEMESWAEALVGEVGMGLNVEQRKRLTIGVELAAKPKLLLFLDEPTSGLDAMAAWSIVRFLRKLADAGQAILCTIHQPSGELFNQFDRLLLLQKGGKTTYFGDIGHNSQKLIDYFGKRSGKTCGEDDNPAEYILDVIGAGATASTDKDWHQLFLDSELYSDMVQSLEQIDASGADHTVTAEEEMMGRREYAEPLSVQVGLVLKRAFTHYWRDTTYITSKLALNIIAGLFIGSSFYGQGSKETSASLQNKIFAVFMALVLSTSLSQQLQPVFIQFRALYEVRERPSKMYSWWVAVWSALLVEMPWNLLGGTLFWICWYFFLDFPTESKTAATVWGFYMLFQIYFQTFAAAIAAMSPNPMIASILFSTFFSFVIVFCGVVQPPPQLPYFWRSWLFYLSPFTWLVEGMLGSVLTGRPVRCAPNELNAITPPSGQTCAQYLANFVTTLDGPNLGTGYYQDGPNGTCEYCQFRVGDDYLRTIDMNAANRFRDLGFICAYILFNIALCFALFYFFRIFKLSDWKKADNSKVVPKADEGTQKADEKVTETSAAAKGAGDDAAAQPLPATNLLPAAGVQGPQTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWN1</accession>
    <name>W3VWN1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWN1"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="356" mass="40289" checksum="C16C2F34EFCEB776" modified="2014-03-19" version="1">MASSQPQTVPCAYKTGRTLGQGTYAVVKEAVHIKTGQYYACKVISKKLMEGREHMVRNEIAALKRVSQGHRSIVTLIDYFETMNNLYLVTDLCVGGELFDRICERGNYYEKDAAHIVRTITDAVVYLHNQGIVHRDLKPENLLFRDKSEHSDLLIADFGLSRVVDDEKITVLSTTCGTPGYMAPEIFKKTGHGKPVDMWAIGVITYFLLCGYTPFDRDTTMEEMQAIINADYRFEPKEYWSEVSDQAKHFIDQLLTIDPSQRLTAKQALDHPWLQSAAPDAGATAATDAQKDLLPDIKSAFNAKRTFRKAVNGIRLINRLRTNEHVPNKDEIEKLRQSIRDAEDESNNLDQVMPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX19</accession>
    <name>W3VX19_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX19"/>
    <dbReference type="HOGENOM" id="CLU_1220479_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS65316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="220" mass="24506" checksum="22961059D2428F95" modified="2014-03-19" version="1">MDTTSLSLRLSTLAHLVGTSAEASVLPRLRTIAAGLDDVPDASLRFLLQHWPEYDAHLQPLPPAHPDAQHAVHALQLHDELATAYREISDIAALQGALDAKANKALASKSPRSHFLTQAEALADDDVHTESVDASRLHMAKQREEEQDERAKSTHQRVLDLVTNWANYVRPPHTHPQQAKDDRLTGHDMQTTSVSHAFVLLDTQLATLERQLARLERERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD44</accession>
    <name>W3VD44_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD44"/>
    <dbReference type="HOGENOM" id="CLU_516907_0_0_1"/>
    <dbReference type="OrthoDB" id="4866090at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="527" mass="59222" checksum="799F89F2CDA29502" modified="2014-03-19" version="1">MASPRSACHASLLTREGPPSYQPLTTEPAKPYIQEAYGRNAKSLLEGIEHNKTATRVFWFMAGVWSAVIISCLALANAVGSLSGPEAYEELVEVKRALQAGHFVGIGRRSSTVWERAWKMFVQPRPCGAGAALGSRSHAGRSQHVKPDRGCCDVGHADGEEQNGDLPIAESSSAVYSNTMARAALRLLAWLRRIRCPPPPDTRLGWLRSASASKQGNPRSASLESFAVLITVRAQPAHHRLWLELKSFSMISRMARFIALRPMTLFGLSALMIFYAHLNFYEDKQRAFNTLYRLLDISYNSNGSEPFLTIFRDKHRKSFLHQRVEDNPLTYKYLHVYMAVFWSIVMPLQHIDSFRVKYPTAHRVCGYLTLTGSFLLAATGLTFPFRGLSYSLPAPLSFHYAFGKWYLPFITFNQGLFLAAIPQLFTLYKTVKYARRRAFAKHRYWAVLHTTSCYAIHLFRVYLAIAFMLGTVLAKSPLTFQTALGVPQGLQEKEDAERAVFAFCTVLAGITGFAWTRKVLSQAPKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDA0</accession>
    <name>W3VDA0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDA0"/>
    <dbReference type="HOGENOM" id="CLU_2016229_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="123" mass="13478" checksum="229B9DD2920F8636" modified="2014-03-19" version="1">MQVPQAEKKVGGQRRRASTSMLTRGRGNLPVYLPARPHARSLATPSKSSDLAIRLATVSVPSRLSTFAHPWSSLQLLLIVLLLWQATLYLRSCCSYTALARPGTSSRLSVAWQHHCSSGFSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDG4</accession>
    <name>W3VDG4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_06492</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDG4"/>
    <dbReference type="HOGENOM" id="CLU_000288_109_1_1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000973">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="46"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS59570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="451" mass="48720" checksum="00CBA704AAB2DF91" modified="2014-03-19" version="1">MPSIQSSSAGILGSLFERAQDAIFALSSCLPCTPETSVLKLNGRNFQIVKLLGEGGFSFVYLVKDQASGRLFALKKIRCSGYGADSFQEAMKEIEATKRFRSPHIIPIYDSCVVQDDAGSGTLFGNLPSNDPDGAGGRGSDGGKVIYLFLPFYEKGNLQDVINAHVVRGTRFGEREMLNFFLGTCKAVREMHHYRLPNVGATRGGAGSSTIPRMEVTPPQDPFSDSQAADTQADQAPLISGEQQLEDADDDNASYPPKPNKGKGRDFGLDSAGDATHGGAEQGGAGGLLPYAHRDIKPGNVMVADDGQTPILMDFGSTIKARVHIKTRKEAVAHQDLAAERSSMPYRAPELFDVPTDVTLTEAVDIWSLGCLLYALAYLHSPFETTQTVEQGGSIALAVLNGSYKTPPSSQDPYSEKTREIIKRCIQVKPEDRPDIDQVIELTQTALRGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE28</accession>
    <name>W3VE28_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06321</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE28"/>
    <dbReference type="HOGENOM" id="CLU_1111779_0_0_1"/>
    <dbReference type="OrthoDB" id="2552903at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="250" mass="27090" checksum="7F52D71FCD53E48E" modified="2014-03-19" version="1">MEASLTHATSLHPTLHVSIAPSLLANVAHCRPSVLVHLPAGVFFDPFTASHTLTRKQDSHYKFVHLASSVELEHAVGRSGGGSEVETVIVEVDSWRNDGLSVDIPLHTRYQPPAKGERSGWTRLASQLLPLSSPESVKEKQDYVQVDIQQPKLVLTCKDESRYVEGFYATAMQSLLPPSHKHLAKSNNQVLTPSAANKHTLKVNLPVPDAALLTPIKAITLATVLAAALVVLAHLAFNVLPLIQHAESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEE6</accession>
    <name>W3VEE6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEE6"/>
    <dbReference type="HOGENOM" id="CLU_295630_0_0_1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002497">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="281"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1034" mass="110870" checksum="33115C389CC35DAE" modified="2014-03-19" version="1">MVPAPRRASPGADDRQPSDPSAIAASKHSKPSTSRSRAPWPLDTFWSSAARKHSSAKSRSPASPEPPPLGATLGSSYESCPDQPFDFNDLPLTPPDSGGSAFELHPATAARQQPPPLVAAATLEQDFKPQQKPHSKNDIFNAPISWLTPPSRINPAPPSQPHTAAPPPSKNSSFFSSFGSASSPQPPLQPPPPPARLHNAPARSSSSTHAAVTSTRQLDSKPAPFAPAPTIPSPSAAKQQATGRKLGHSRNSSLGRASSEECLQEEARIRAAKHVDFRLCPTNEFLLGEGRHCSVYLGSYRPTHDPLPAASSSDSAYQASMWRLCAIKRLHADRQSQLLGLDEAFALRRLGMHPNIIQLIDIRDEVEFATAPDPSANPHASRPDVPSAGLGLGLGLPRIEGRGALSTPLGHASHARSTSDMTGKDELIFETKSHKRALAEEIERRVARDSLPDSHPAERTRVVTTEYRASDLRANPTFLVHVPDSDAQEIGANANEADQRIHTAPVRRSASTALDPPRLLILLELLPHNLALYARKHADRIDLQQWLDWAHQMVEAVAFLHDKGCVHADIKKENMLLTDGLDIKLCDFNSAVFPNPNDPPRDGLGLGTPAYCAPELSRATGGPSATSFSYPIDIFSLGAVLYSLATGAEPFSKARSVVEMLHRKRLFFESEENDRASRLAVEAGSNPNSQPASRSGSLRGRHPKSSSASINETPAGAASPAQLASSLHRILQLGSPAPRPPRREASSDSLESVASSITTIAGRHPSSLAVSRLLEPTDEPRGLLVDRSGPMRKNSLLFAKADVRRAASTGGRNATAAGSAALQRLRISRDEGVSALASPITAAGDDHAPDATDQPAVRKGAPGVARVTMLEATSRPDWLRRRSSYGDEVRAQSAHHSPSDAVAIAQVSGSELVAERADELATTPTKPSRLRTMFSPMSTAFPHLGEHDQLVVENSAHETATHLAPDDDTSAWEQHSPDLRPYADGHPAIILPAGGRLPDWARDLLRDMLHADPAARPTAHQVRSRLRSAALSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEM8</accession>
    <name>W3VEM8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_06005</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEM8"/>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="531"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="340"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="688"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="805"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1037"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1240" mass="140489" checksum="6A1F9824C98571F4" modified="2014-03-19" version="1">MPLKRLEIDNFKSYRGHQVVGPFNAFTAVIGPNGSGKSNLMDAISFVLGVRSAQLRSSQLKDLIFRGRKMGAANDDDDAPGSASEDDDDQGEGTATKASVTAIYEDNKGYEHRFQRSITLAGSSEYRYNGRAIQYSQYNAKLEQFNILVKAKNFLVFQGDVEAVASQGSKELSRLIDQISGSLELKEEYERAKEAQERATDNSTFNFNKRRGINSELKQFREQKSEAEKFQRLQTERLQHILNHILWRLFHINDDIELNTQFVKTQAKNMRPLRTEHKKAEDAVLKARRDQGHTQTEILQLERAMKRKQRDIEDIRPTLDAYEEKITISQKKLDNGARMTEQVERDLEKQRANLAKLERDQQTVQRAADRAAQEQQRALESAGLTLSEADLGEYHNLKAQANLEAVAERQELDTLKREARIKADAVKDYEDKLDQFTKQKDKLQGEESTLSDRHASLEAKRIQIDTDLRAARDELAKTQAKHTAINQRETKLNDTLQVCYNKLLQAGNDLKEVEREAAMKETMAKLQRIFPGVRGRVVDLCKPVQRKYDTAIATVLGRNTDAIVVDQEKTAIDCIEYLRNTRAGQATFLPLDRIQAKPINDRLRSIARGARLAVDVIQFDASIERAIHHACGNALVCDTMDIARSVVYDRKVEAKAVTLEGTVIHKSGLITGGQSSSSGGKRWEEREVQGLTTQRDKCLAELKELQKEKRAFVSDDDMVARISRLEADLRSVQEEVGAASTRLAGVRDELKNNDKQTKEMQPKLRAARTEHDKLQRSMASLDTVVNREEDRIFAPFCRRIGVDNIREYEERQVRLMERQSDARLEFESQLARLTHQANFERQQIATTEERLETLRAAIAREGDKLRAWQAQKQGRQDELDGMQGEIEDMQTQLAELQTTNEAKKAALEKRRTELAKAARLLDSLGKEIAARNDEIERLGSERAAIYRRCRLEEIALPLLKGSLAKVGLEETIDVDVPMDVDDDDNTQKPMAAPDFGIQVDFSTLDDEAKEDGGVAMGNELQTRIESITAEIEKMSPNMKAVERLDDTEAKLAETEKEFDRSRRAAKEARDEFSRIRKRRCDLFNKAFYHISTQIDATYKDLSRSKAAPMGGSAYLSIENTEEPYLGGITYSVVPPMKRFRDITALSGGEKTMAALALLFAIHSFQPAPFFVLDEVDAALDSQNVAKVSNYIRQHASDQFQFIVISLKASLYERSQSLVGIYRDQDVNSSSSLTLDLEQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEN3</accession>
    <name>W3VEN3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_06010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEN3"/>
    <dbReference type="HOGENOM" id="CLU_271827_0_0_1"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="732"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="732"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="829"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="969"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="985"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1068"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1103"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1114" mass="119389" checksum="93C81EF2FDA16EB3" modified="2014-03-19" version="1">MSTSAASSLTQLIHEAAEQTKLPISTDALATKEVASYIRSLSNLSLSDLRNQPQQLHAKSDALHVQLSELCISQTDAFIHIHHAEQRFGPALDSLASNLSDLIQTSIPDLQAAADAFLAQSQPALDQKKHIQNVADQYERGHLSDLLDIPPLVHTCVKAGHHSEAIQLTEHLIGLLDAPATPSSDSQAIQHGQRSTYLSLLIETLAHLAAMKADLLAGFSKPGIKLPAVRKSVTVLRRLSHIQSSLARIPDWTSIRASERFPSLIPQLDITENQLCLVFLKARINSFRASLNAMGSPSTVNSHAYLRRYIDLWRQEMADTLGMAFPLFVDDPTAAQHSNEHADQDDMISPAYLLASFATSGLDLLRRTVSTHLKAAAQRLSASASVQGESSASLEAFAEMCSNVHTQLSYASAALARFGLDFGELLFSPVDSTAQGLSSMEAIWLDLLSSSLDQAFSYIHEQLDQHTSGIDASLPSQWLLSSQLSSTALQELFTVSTSGTAPSGYDDFARPNIELVDYPPFAKLLNRLMEWINALQIFAPVSLATPLLQRLDAHFSRVTERILADIPQAITTSRGDATHITRLLADDDAKSFLEHLDPEAKLDFEKALVGDRESAILTKALRIWNASVVQWVLHVVQSCFSDDDSQLQARFEQLEMNAAWTKAHDWIQSTEARIIEDDMKRKKDAKARKSAVEQAEAEARKKAEAEARAKVEAEAKAEAEAKAEAEAKAEAEARAKAEAEAKAKAEAEARAKAEAEAKAKAEAEARAKAEAEAKAKAEAEARAKAEAEAKAKAKAQTEARAKAEAEAKAKAEEEARAKAEAEAAAAAEAKAEAKAKAKLEAEARAKAEAEAEAEKARISREEEAAAKAKAEAEAKAKAEEEAAAKAKAEEEAAAKAKAEAEAEAESARVESERAAAEAEAAARAKAEEEAAAERARVAAQQEVGGTEDSTQDDTDAGAVQAQTPGGSDTAAPAKPAEAAPTKKFSLAEKLRQRKEERDRAAAAAAAATSTSRIETSPEQARQADEIGSSPHDVAPEEASQTTQDEEPKPDERVEAAAAAGVEAGGSDVQDEARDEDDEGDSGANTPTTPATPSTPNPANSPAKKNKKKKNKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEQ5</accession>
    <name>W3VEQ5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEQ5"/>
    <dbReference type="HOGENOM" id="CLU_933887_0_0_1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="346" mass="39081" checksum="D79740AD7EFF25A1" modified="2014-03-19" version="1">MTTDDLQVQQGATEGVWGELFFTYADEELDHDPDSYLKLQKPHRERPKRGVWKQLHSLRPELDQLSTCSEAQRIQTARVDLAKRGFAVLPHFSHALEENGIETQEGYSQFVRENQQLIKTITGADEVIVWNTVKRDSAVSASASLDDDYEQQQRPQGIESRFDKPIEPPALFAHIDQDPSHGARVCSMAIAGTPSLLTQAQNTAMDPSEAISSNLSARYARTMIVNLWRPVGGTVYDKPLALADYRSLDQCFISRHANPFGCGYDLHAHDKQQWHFVPHQTNHEVLVFKCYDSLSLQHHQRQSGETQEALYGAHCAVTRIKGDYPAPPPNAPPRKSVEVRFVAVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEY5</accession>
    <name>W3VEY5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEY5"/>
    <dbReference type="HOGENOM" id="CLU_030118_0_0_1"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44016" checksum="2D3EA64350E7E5F8" modified="2014-03-19" version="1">MNAVISASDIKTFYSALNCLSRFSDTFWLQCSRLNNGQAQIRLSAINATNSAFCMFVFDPDFFLSVATQASAKIECQIHLKSILSILRSRGRTVERLELDLTDSGSECRFTVALHCQHGILKVHRLTYEPKRGLLPTADPNPPNFFCIAAATATEWTDHFLSSNRNGEITFACTPSTCVARSKDDDSPDPKGGLRRAIHTEVKIAVDEFREYAVLDACALTFSLREFKATVALAEALGVALEVNFSDGDEPLFVRLRVENAVAAEFVIATTRPDRTNAPDKEAAPAAVARSVSSSVAPPAARETQRQTESSDASIAPPPPVRPPVESTPVNPVQAQAPLFFPGASQPSQPEPEEQTQPLPPSPQFVQPTPVARGGDPGEFLAPSESDTESEPDPAAPRKRFKPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF23</accession>
    <name>W3VF23_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF23"/>
    <dbReference type="HOGENOM" id="CLU_950517_0_0_1"/>
    <dbReference type="OrthoDB" id="2556020at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="276" mass="30234" checksum="8FD1306DC870B784" modified="2014-03-19" version="1">MASHAGYGANAGVRTLVASLLLSDPIHIDASVLSDDVHMRQRMLGLPRTAPFAPDLEDAHTQWGDSPALQEAFIRWFCRDPIEVTESALSAKTARSFFVQRRRALDTAAEGERDPIDMERLTMLCKDEWHGTGRLLVQFPGDPDLAMLYMSVVRDGTEVKLDNLFALDDPPAGLHHHTPACWESYNVHDEDAPAAAEYINDADEFWSGFDDPAPAPAPAHAASAGVSEPAHTPTDADESAAIRDIVRGAYTLFRSRHPLDSTETFLELVHSAIAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF47</accession>
    <name>W3VF47_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF47"/>
    <dbReference type="HOGENOM" id="CLU_845023_0_0_1"/>
    <dbReference type="OrthoDB" id="2556786at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="329" mass="36340" checksum="2B9D1D959A59F5B7" modified="2014-03-19" version="1">MEAIEGPDTKPKRLRAAKACDICRTNHRKCPGPAPGSDSCERCIKQNKQCTWNTYSKDSLRRSESASPSIRRTPVRRALSTPSQQHTPVPLTPNRARRSSTSSSSSSELSTPTNSPAVPSYKQPLETTAFGPLTEKPSPEEVPSYYADALALANRHELLIFAMPLREWDPSVRAQSRLHCVTPSWVDPQPTRQESLDVLRALLDDVEPASEERTPSQTSSPEQAKIQHTEDVPMPLDPVPFGEGMAACFADASVGAEFQPGFYMNAPTGNKSPYRQNCTHDPFLFPPAQPADKHTGVETKWSASWDDAMPQVLRDASQMDTLDAYLMHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFL0</accession>
    <name>W3VFL0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFL0"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="563" mass="62124" checksum="A727211058D4FB0A" modified="2014-03-19" version="1">MQESPSNSSHEDVYKSEKNDLKIVHAGEVNINQVQGFDAPAPSKMTRRAQVLALAICTGGFLFGYDIGVISGCFIMKPFVLAFGDPSDCGPDGCALPDSRTSLINSSLSIGTFVGALLQAPVSDFFGRKPSMITWASAFMVGAIIQTSTISSWVQFCVGRAFAGLGVGALSGLCPLYLGETAPKHIRGAMVTGYQLLIIFGIFISYGISWATQNFKTSDAAWKIPVGLQLLWGIVMLSLMFFLPESPRYCLKNGEVVRARKIMASMRDVQLQDVNGEMRGDKWMEAELLEMKQGIDEENRIFAGHSYLGSYLVCFSTKNQMWKRTVNGMMLQTLQQLNGQNFYYYYLPLLSSTLALPLDPFQIQFILGSASLLATVPALIAIEKLGRRPLLLIGASCEAACAFIVAFVGHYKTAPKDTPADMITASQHQAGAVFISFAIIHLIFYSCCFGPGPWLYLSESFNAPTRAKAISLGSASNWLWNFLLSYFSNKIATQYGPFIMLIFGSILVFAWFYVYFMIPETKGLALEDVEYLYSQNIAPWKTPKWIKEHGLNKSIEDRATVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFQ2</accession>
    <name>W3VFQ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFQ2"/>
    <dbReference type="HOGENOM" id="CLU_004852_0_0_1"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833013" description="Gylcosyl hydrolase 115 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="3">
        <location>
            <begin position="877"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1072" mass="117205" checksum="33FB07A1D1E29093" modified="2014-03-19" version="1">MRTIVLALWALLALFTRAIGANNVCLGNDGGYAIAKTGETTSILTSRDDAAVIHHAAASLATDMMRMVPNAQVVVRNVSAASAMQTTSERVLFVGSSTSALIQGLATSHGSVASQASLLDGKWESWSSVLLPDRGVVLMGSDRRGTAYALYTLSEEMGVSPWKWFADVQPTTTHNAVYYSPSRSDGSFGSNACSHGPPMVKYRGIFLNDEAPALTNWARTHFGGPFPPASSQSFNDAMYTHVFELLLRLRANLLWPAMWADSFAVAGLDDLPNNGTHGKGAAGPNQLLADRMGIVFGTSHQEPMARNTPEWNTWYQGPWDYTKNRENITAYWQYGVDRAEGLETMFTMSMRGNGDKALDGANIELLETIMAKQKSLLPHTANGVSVPMMMCLYTEVQGYYNEGLRVDDDITLLWTDDNFGFIRRIPTADEKNRSAGAGLYYHADYVGPPRSYKWLNTVNLVNAWEQLNVAFANDQREMFVLNVGDLKPVEVPIHFMLDMAYDSSRLSHASNVSTWLDTWAAKTFGAGPNDEHLKIAEVVRGYSWLNSRIKPELVNATTWSVVNHAEAESVLAEWDRLETKVSELEPYFRDGDNWDAFFQLVAYPTLASANLNRMHVAVGRNNLAGTQAKNSANHWAARAREHLARDAELTSAYHSLGNGKWKHMMSQPHMGSQYWQQPMRNMLPPLAYMHLDDTWADTALGSNLRVGVDGSMGAWPGDNQYNCPDGYNCPDPTLPALTRYSGDQRRSIWVSAGDAQKFAFSATTNASWLGVAHRLATDSANATQGARYMHRRSDGFEAGAEFDDEVEVQLSVDWTALPKPSCTGAAQMYTAMVYINATNNERLPGMSAPTNVTVSLSVDPCMPHDEAAAGTFVASPDGSVSMLASHATIESARDTSFTPAYIESLPGYGLLGSAVTVLPPTAESIDGNDTANLGRGPSLAFDFYLPHSSGNETAFNVTAWLAPVLNYRDKRPLRYALELDSDAGSRVQVTPVPENITPGTNSADWGNVVSANIRTVTSTLSSSTATQGGKHTLRWWPLEPGLVLQKIVIEPHGKLSARTTLGLPESRRVGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFV4</accession>
    <name>W3VFV4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFV4"/>
    <dbReference type="HOGENOM" id="CLU_110778_4_0_1"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF2">
        <property type="entry name" value="MAPEG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="190" mass="20839" checksum="E52359D35DDA61F5" modified="2014-03-19" version="1">MSSITDRAANFISRVNPLKDPGFAQDASRALHYNYGPISILAAFAGSHLLLQHRLPMVFYGLDNMAYPRDDLRVHGDKAVASGKITPKTLRRLKRWEAAHYNAVENLPIFIGTIVSLQLARAPNSLINRVAGVYLTARAAFAALYITVESESLAWFRTLAWWSGNVTCIYGLVQAAKMLNHGVGTGTPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFV5</accession>
    <name>W3VFV5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFV5"/>
    <dbReference type="HOGENOM" id="CLU_2813472_0_0_1"/>
    <dbReference type="OrthoDB" id="10449282at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="67" mass="7731" checksum="0171BB1D389119C5" modified="2014-03-19" version="1">MASQRPARATYNSTTPIREESNPYLPLATSEDVTSNELRPMNEVPKALDYQPRKSFLERIEHNQPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFW3</accession>
    <name>W3VFW3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_06550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFW3"/>
    <dbReference type="HOGENOM" id="CLU_1300176_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS59626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="212" mass="22849" checksum="67DA9637E76D4E36" modified="2014-03-19" version="1">MLQCSTLQFAAKAQTNLQLYGYGATCCKSSLSLVVPAGLHRLPTVAPRWSLRTLWENGPVLALGLPSSSLGGSGLWIQLETLHICSAGKHDRSSTLSPPGRNQVQIPLQRCRSSEIPEFKLFMLRPTVAVLRSSDARRFMKRPPLVFKAPGPEPTKCPLRVSGNSLDPGSRMLSPDPPPTCHAWASPLGRVGFALSPAQIFGSLIVDASLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG35</accession>
    <name>W3VG35_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG35"/>
    <dbReference type="HOGENOM" id="CLU_009570_1_0_1"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF6">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="354"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="955" mass="105559" checksum="7FDE2D8835D82B83" modified="2014-03-19" version="1">MSKAVSQRASANSLRGGRSQHKRHVSLRHLPDQPRPEDPIHPHLLDSTSPRSSAFSISSTEQHLGAASSSHPYSAGTLQLPRSGAHIRTSSNARRTTEASAHEIDRLLESEGEDGVNLIKVVERQDVFHLIHLIRADLRKTIDTHLSWEELTSVDLNFSLVRPLAIKYSNFRSIAILYCLMLNRIYFQREATRDLAFQSVNNTRSALCELLAMKLLRTFSNDGLELVTSLTASFHPLAGATYAELKELRLSSSHVDFDDIVSHGLPPKQYSNTLELAIASSAKRFISTPLCQRCIDGIWNGKVVLSPVQASHAILNDSYKKRPLSIYDPTKAPLLNHLRLRVPSIRSKLEFVTFVVILVLYVAALAQKGSPTWTVQETLFSIWLLGFAVDELAQLQEHGLSYYLGSLYNLIDASFCIISFCWFGLRISALRHGLPGRSDLSFDCLAIGAVVLCPRVASSLVQDNVVLLSLKAMLSDFAFFTVLAMVCFSGFAYAFYSLASEERWTFKAVLWLMLKVWFGSSYLGFDEAKSFSLEFGPPLMIIYTIMSNTLLLTVLISLLSNTFQVVAMNANEEAMFQFACKTMSGITTDAIFSYQPPLNLLAVAIVMPLSFVVSPRWLHKINVFLIRLTSFHILLFIHFCELNVFGQGISLTAEKGKSILSRLPIFSSGLDHSTADVIEAAFDFPMEQDKDEWAAAADEARSGDEADAEGEADEVVDAAVKKAKHSDGGASLAVKANGSWEERAAAQLERRLTPQPDQEGRSIGEALAAPSQDPLPRSTTQTSFAGSTCSRRPREQGVSRSVQLLRRGHEPRGLGSLSSPLAKLFNRVLDPSELDEGPAKVGPSRSRSRTGRRAPDVSRDSSPDRSRQEQKRRQRTTEFDAATAAAVAALSEDTAAERIETSYGGDSFDAELRTIARRVQDMEARGKRMENLLLQLLATANRTPNQRTPHAPTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG45</accession>
    <name>W3VG45_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG45"/>
    <dbReference type="HOGENOM" id="CLU_030733_1_2_1"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="486" mass="52449" checksum="29CFEFD1C2DE5770" modified="2014-03-19" version="1">MPLITPALRRAQASSSAPGLAASTASTATLAAQSLPPLPAIAHDAATLARVAPPIKQIHSEEDVHVWQQSEAYAVYTLFVQRICEACVGKPTRLPPPPAATAAKEGAVERLVRLLYELNSWTDSIEPHAKPQRFGNLAFRDWGARLRQRIEKLHHELLPPHLVAFAPELGAYLLDAFGSFTRIDYGSGHELAFFVWLSMLYRLGLFTDSTWGEVADPRVEEVLGLEVFPLYLLVAWRLQDRYGLEPAGSHGVWGLDDFHFLPYVIGAAQLRSQSALRPSHVNAVSAHASILQDQLGSARDPATLISRALELPSSLLSGNEGVVVPNLYLSSLLRIQVLKRGPFHEHSPLLHDIASSVPNWIKLHAGMLKMYAAECLSKKVVVQHLPFGKVGLVWPDNPAPVAGQATVPPARGMALGGRQGNLGSLGVPTARQGASVPPARATGSLGQALAMPRTVPPTRLQPSTAMRTPSAHTTLPRPPQDKPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG69</accession>
    <name>W3VG69_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG69"/>
    <dbReference type="HOGENOM" id="CLU_020336_25_0_1"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="307" mass="34212" checksum="F892B52312A28E37" modified="2014-03-19" version="1">MTTRFLSLPDGQGCRMAYRVCTPASAEARARTPLFLINGLSAVMVDWTPLFEALGASRTVVISDHRGIGESTVGEEWDQDLSLESMGMDVIHLASHLGFTTIDLLGFSMGGHIVQALLSSDTAQVQDGMVKLEDVAVRKAVLSATMTKLPRGDVNLNALNKEAEKIADKTQRNDFITFNMMKVQYHDEVLGEGKQMEAKFRQRLETVRGTKRPAHTIALQFLAIQAADVRENLHRIPASLPVLVIHGARDRMVLYNESDHILKGIKHAKRLSTPSPEFGHFWYDYFDIDFWSNAITSFLDSPARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGA8</accession>
    <name>W3VGA8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_06269</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGA8"/>
    <dbReference type="HOGENOM" id="CLU_037162_0_2_1"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="342"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="528" mass="58140" checksum="60EE6B66801DA3CA" modified="2014-03-19" version="1">MSRLVARALPAVRIQGPKHLVPSTTTRSLFSLPPTTRPHRGLRRPVVKMATQAGSFPSFTTVNFYAGSKLNRLSWLRTSTEFLNSTIASPQTRFVLMKHNNPLCHGSGDNEGMLATFSWDEVKKHVLQNVEASGGAKTGEDASVFGPQAYGLTNGAGEKEFARATDGVGPSRLALVFLGIDESELTQTSLPGQMAKDGDKAEGAPAGVPYFALSLTYRPAFVEGEAPMQALLDEIEAEGDKYDFLDLRASSRASAWPREHAAIVAQAKSLLDWNERHQYCPGCSRQQYSLWAGYKRGCSSSLGLAAPGSHFATAFLGGKTSFEEDGKGVCPSTQVLSNFHYPRTDPVIIMAIISPDGEKVLLGRQKKWPAGFYSCLAGFCEPGESFEEAVRREVLEESGIQVDQVIYHSSQPWPYPTNLMAGFYGIAKTDDAESIRLDLDNELEDARFYTRQEILDVIERKKNAHFTRAELEKLDKEHHTSDGEDKAKDKAQIRLPPDTAIARVLVEAWAKGHAVLPTHMDNFQKTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH02</accession>
    <name>W3VH02_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH02"/>
    <dbReference type="HOGENOM" id="CLU_007708_0_0_1"/>
    <dbReference type="OrthoDB" id="2554316at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="833"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="934" mass="101418" checksum="380F53D3DB669119" modified="2014-03-19" version="1">MRSTWSAAPVRVRHHSRDAFDRDDGDGLQFGSGVISVVLASRSRSAALTLPPCATRPLPFSTSCEFPFATLAGSTSRAAHAAASQTSGNWLCSATALSQFACTPAESLTSTNPSALDHPNPTTATPLLLALSRSAPAHVDTGDAIGTKERELHQPTPCHRDVGYPCGTPTRTPQNFELYCNAGAPRRQGFLHLETTRRSINKMPGGLFGRSRPRDLTVHVNPARTGGPVVDPEPQMSTMTVSRHITSAPKETAVNLFFYYFFYLLLMASAVITIIFAQRPSSNFDQTFDVQSLPGVIFAWNRDAAVTPVSAISSGGDESVESATCTPYNWDRGTRVGFDCTSIAPDGQAKLVFSLYSTTPYPPTVRGYRATTNRYDDVSVPTYYVKYYTYLPPRSTSSIPSIAATASPSARLAPRDAVVQAQASSPLYLGPSRTQVARTAASATLTPVSLQARQVGNVPSSATSATPAPLSSLSLIKIEYVQSSMSALVGGTIVSVSSMPSPSTVSINARTAKMNDGFKYFFSAIAVVPAFFATLTIICVSYNLSVAARRVRRSRRSSGASMGPVQVGQNDVEEKVERKPRPSKRNRRAQSAHVDRDDNRWTRDTLTAINEVGETDATSTMSKPSTKPPAYESGTVARRASVDSRNVRPGARAPTVMTGVAQMADGDSAPPAYESRPPSRVGDARTVGREDDDIEVIATPSDSESEHTAEAVASFFSSDRPAPDLSLGAVDSMATPRTWTKRSSSLLVGWMVLPIYAYMFWWDYAAFIVVGLLQIAAFSLAADAMLDVGKFVRDDACLGDGDNYSLYRSLCGRGRFRATYPLIYTETRPRTTIWLFASDLLILQISLVVLFVANLGWMITIMRKTALTERNKLEPDRRITNERHTGRSGPGYIVVLHKTGNHGKYGDWKAADDVYALEEMNRAQSRRWGMLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH10</accession>
    <name>W3VH10_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH10"/>
    <dbReference type="HOGENOM" id="CLU_297746_0_0_1"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF18">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="916"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1003" mass="103616" checksum="A41A21672579E99F" modified="2014-03-19" version="1">MLPPTHTTKASPELAAAADPAAAPHPDAERIKPKRSSSFGRGLGQLASLTGAKPKAVDLMSFGRTKSGASTPQSPSPQSAADNVAAAAAILANPAAATNTHAAAMRPPSTPDPSHLTHFSLLLSDLVNKAFVTCSPGSAPAATTTSSVASNVAAAAKGPTIPKINQITYEGKHLPDTAKIIEIAQVVVGELRYAEAVDAYLLRAVSRQILKALTLFAARIDSLLVSPTKDPGALRIPTNAKEGLHIPAAMEFNLGLVTLEWIVEDSLERCIEGDRDAHGDLIADENGAVHDGMPHFVSEILTPVRKRMEGTILHIIQPILAQTKASMARCISSAVPTPFVSTVTLSPSTTSGSATAALPSDSGTASPPLAAVGAAATAPGAVPGNVSPPLRPGEAGPGSAWLRELDGRLEGARKLLLPRIEERCGQDGEGWFISVAIHVIWKGLMILTSRSVSLPSNAAAELLTGSNAASTSAFDRLMGEVNQKRSPSPAQLAQALKSVGVGSARSKSKGPDATCAASDSGRQSPSHCSASGLSSATPFSLVSARLCAHQLAELQTFEKLMLRFCDGFLRKPGTQSKKAGKDSKRSRFALFSSGAASSLGGSNAPLDLSAYDPDEEDELARAALAEAMHALRATIIVLQCLEREPATICAGLEALKRLPGAESSADSLTGSDAGTPSTPAAAGPAAASAVLGSEAAKALDAIPNLLLLHVLYTRLPIGAGRLELPSPPALFGYTWTDYEKAIAGFAGGEQWAQAVALRYKPEMEKAWKGVEQRRAERLGALQQRGPRTARSVSGCSSARGGSALARGGSKPSSEGDDDDDDDDEEAAEAMSQSVPELKKPSAQTRRSSDEAQRDASAARGRVSPGHSPRRSSTAHAALADGAGAVAVGAPAPPRFWRRSTSTARSGFHLSFAGLRAQSPRASPASESPAPGAAPATPPVSATTTDPLASPPAPSTAGSETLEARYDADAQRIRLEAALERRSLCVFGMALTYAARGQMHINLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH51</accession>
    <name>W3VH51_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH51"/>
    <dbReference type="HOGENOM" id="CLU_694820_0_0_1"/>
    <dbReference type="OrthoDB" id="5569309at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="390" mass="42226" checksum="452BAB23D8702C46" modified="2014-03-19" version="1">MSSTPFKGSLKAKRKGELTEIAQALGIGLDQSQKKEELEDLIREHLLSHKNQYSSDDNFRGLIDSLDSGRRRSARSSSVNGNADSDASDSPESSVRSPRKHSQRPSNLGTPSTPFGASASELATTVKQRGLKARKSLDKLVDSIQDSARSTAHELTSEVQDAQSEVAASLQAVQGEAAKRYRKAKNAGNKLFVRTRTWLSDAHNLVRLLIAFEGILLVLATLPTTYVQLGSRGPHIPVVNPKSGINGYLPHWAITLPDPRALVSVAFYRPLVLWAVYSVLVPLAVAHLVTFDRRSQPSTYSFLLARLSALVFLARVLPNSTLTALGLPAPAVLGVAAGEVPESALIRGLRSLFSYDYVLAHLGVDLQIWATATAFGFAQYEAIAIRPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHZ1</accession>
    <name>W3VHZ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05627</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235129_0_0_1"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DH_dom"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
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        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0728">SH3 domain</keyword>
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            <begin position="230"/>
            <end position="319"/>
        </location>
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            <begin position="263"/>
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            <begin position="1"/>
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            <begin position="13"/>
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            <begin position="55"/>
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        <location>
            <begin position="369"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015110"/>
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            <dbReference type="ARBA" id="ARBA00020728"/>
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            <dbReference type="ARBA" id="ARBA00022443"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50010"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
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            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50222"/>
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    <evidence type="ECO:0000259" key="12">
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            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2145" mass="230229" checksum="71CFCF72FABD29C9" modified="2014-03-19" version="1">MYNNMQGQGWGRPMQPQMTGYPQQQQQQQQQPMQQQGSGFLQPQQTGYPGMSQFQRPMQTGFPQQQQQQGLMPQQTGMMGGGMGMQPGMQSQLRPQATSNFGGMGMGMGMGMGMGSGMGGGLQPQQTGYMGGLQPQQTGYMGSAGGLQMQPTGLMPQMTGMPIRDPRMQLMSSQFLPASQPFSGAPVAGNMNFSQASMQPSNFQSQIQTLSQQQQGSKEPRIPWALSKEERKSYDSIFRAWDSQGTGFINGEVAREVFGQSGLETDKLMQIWHLADTGNRGKLNVNEFHVAMGLIYRALNGNDVPETLPSELIPPSAKDLNDSVDFLKDLLKKDTSVRHGTGLNLPEAGSNSGASYAKARSFHQNPVAPKKDATAYKHDDADVPSYKSSSRHLDRKTVRYEGQSATDDLSEMKRQLENTQKLLDKQGADDDEDRELDREMDDLRYRIRRVQDDIEYYNRRGGRDSADLRRKAERELMHLMHERLPQLEKRIEARESRQRDRKLGESRERDRRNDPYNRYASEDRDRQNDRGPSRSGSTLGDGEYLRGTFDRDGDRRSEAGYSRDRYDDRDSSRRNDDYRERDADRSASSQPSTPAEPPKPAPAPAAPASPAPAASGPPKNMSAEERAAWIRSEAQRRVQERMRMLGAVAPAGPTPVDTSVEERLKAEQAEAAAKSAQADAEAAAREEARKARLEENRLKTEKASLATVKQEIKEAERSDAPPPAPVVQAAKEEINDQEDMIRRREEVLAKEKAEREARLKRLEEQEEEARKQEEAFKERQNTFNSGAKPVASSLPPPSRKSGKAGAPPPPPPSRARAAPAAPAAPAAAVTSPTTLAPPAPEAPPAPAQPSPSGGSSTNPFHRMQQGAGAGAGVTSPPAAGAAATPSSGGTNPFFRSQQAAADSNLPAATRATPPVSAQPTGATPTSASRTIHTAPKHDDDDWEESDKDDDDDDADGPGSSTRATRQNLAQALFSNLIPSSGRSTPPASAPAAPPAPPAAPAAPAAPVAPAAPAAPKAPVIKPAEGPVDRGALLGQIQGGLRLKKAQTNDRSKALVTGSVIGDATPPVQTYVPPPSPPAAPQVSSAVAERSIDEAADAPPPPPPAPPAPPAPPMPDNFDSDFGASELAAANPNRQSVDWANSLANDQANTKAAAFVPDEPSVREEAEEDSGDEDEGPEDLDARKPANGHAASGNDEVEGFDLTRSVRVRTLYGYSGQRDEDLTFEENDVLSAHPPKDASSDWWYGSLASGSKKGFFPRSYVEPIDKPVKAKALYDYSGASAEEATFAEGDELLIVDQEDANWWRVDVGGAKILVAPATYLELSGSTPVDGQGANARQTPLDAGRPAGHAQEDSDTGSGVMVRAHSQQSEPTSTDSKSAWVVVDADTKSPSSSKLNVDADLSTPTRAGPSAAQATSAAVDEADEEAQLAAALAASAAEDRETKIARMREDRQVQKAIEASKMEAVAYALGTIDAESSAATRSGVGTEGQASDSEDTDSTTGWTSSDDDDDEDQEDRSATVNAEDQVAPQTEAEIRQHTIERLRVLEAAGVLVKADDLAADAANGADQSQQVGASQADDSVKRTPTKAGRRPPPPPGQKRHKNLDELMMLSRSRTAKRPSKPEEPERRKPPSRPKKRPSRDLPALPTDAASSAAPTQTVDNTAEATEEDRMEDAYDRYLKLTKEVSLQPILPATAAGAAAKNSMVPPASPPPFATGSPARPGSAAGESSSRTSGFLSTIKSMSHRSNWTGSSGAGSRPESGIGSRIVSGPIAMGASTPTGGLLQAASISEPQRASGESSEASESAAARSERKRQEAIFELIATETAHVRDVQIIVEVFFNSMQTMLSAKASTVIFANIESVLVTAVSYLSDLEARQKEDRLFVSAIGDVLERHMPAMSVYLPYCVNQQSASEILAAERKRDTRVDIHLLNLRSNHPAARGLDLSHFLLVPMQRLTRYPLLLAQILRYTPEDHVDRARVASAKQTAEDILAKTNEAIRENEDTTALSKLSQNLWLGEEARLDLTKPFVDPAQPGVKRHRRVLRDEMVAKAKSGRKLRLVLTTDLLLVLHAQDASLYRMPIPVNEVSAHEAKAKSSRHADAFNVVHSMPAVGGGAPQADTLKLRAPAQRNAAAWIKAINAARADAPASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIF7</accession>
    <name>W3VIF7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIF7"/>
    <dbReference type="HOGENOM" id="CLU_052717_0_0_1"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="206"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="297" mass="31979" checksum="DAAB8586793823C3" modified="2014-03-19" version="1">MAPQQKGFSWSNIAVGSIMNIAEVTTLGQPLEVVKTQMASNRQQTMMQALRTVSSRGGILGFYQGLIPWAWIEASTKGAVLLFTAAEVEKVAKNAGFSAGSAGLLGGMTGGIAQAYATMGFCTCMKTAEITRHKQAEAGIKPPSTWAVFADIYRREGLKGINKGVNAVAVRQCTNWGSRMGFARLAESPIRSLSGKSEKDKLNAAERIACSSIGGALATWNQPIEVIRVEMQSMAKAAPGSNRPEKLTIGNTFAYIYKENGIKGLYRGVTPRVFLGVWQTICMVSFADYVREFIGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIR2</accession>
    <name>W3VIR2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIR2"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="32"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="561" mass="61140" checksum="C92361CF036C8828" modified="2014-03-19" version="1">MQKAPNKRWVPSKLRHIHEVPSQSMNWRLLLAVLTMGLLGASRGMDEGVISGSIGTPAFEHAFNVKKKSTKESNIVAMVQLLSTLGALVGYAVSDKFGRVMAGRLSCTLIIIGSAMWMGSAERIALLYVARMVTGVGVGISSVCSPVFLVETAPRQIRGLCTSVYSASIYLGAMLGYAVNLGASRTQNRRNNIVWQIVLILPILWHAMLLIGTFFIHESPRWLLDHGHVEKAHRSLRFYRNLDEDHPAMIEETNLMRTSIAEEHSRHTQRQEALPANSIYRRSNTLLKLNAVFTSRKNLLKVGLGVMIQVLVQWGGPGAIATYANRIMTLVGASDKNGYVMSVGFGATKLGCGVLSAFFLVDLFGRRKTLLCGVLIQGLSMLYVAIFLGLYVQGNHTKGEKTAGEAALAAIFLSGASFSAGGNLAQYLVGTEIFEVHVRSIATSLVMAMHYLLQFSATRALQPMLNSEMGGAGTFALYAAVSLVLALPFYALFLPETAGLPLEEIDQVFERPVWQMARAARAKPHVDEDAIYDVQSSSSSSTGDDEKKVDLQSNVQVRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIY2</accession>
    <name>W3VIY2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial F1F0 ATP synthase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIY2"/>
    <dbReference type="HOGENOM" id="CLU_152700_1_0_1"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12399" checksum="F3E2D9B2D8384B55" modified="2014-03-19" version="1">MFARVARQAAPSARTMRLGGVRNNSSLPIPPKIATPKSAQGPGGSSERMESVVGFYKALPKGEAPQKRGGGIKARYFDGNNASGKPIVATLFTLFLIGYSIDYATHLRHHKNNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ43</accession>
    <name>W3VJ43_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ43"/>
    <dbReference type="HOGENOM" id="CLU_022148_1_0_1"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834562" evidence="3">
        <location>
            <begin position="25"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="4">
        <location>
            <begin position="427"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="750" mass="81214" checksum="213E7E799F39B7D0" modified="2014-03-19" version="1">MRSSASALVATLASSLWLARSALADVNLSPALNASNAGTLSVTISPSYVGFGIEPSDLIVYTGSTSPNQLTYNLLSNLANYTGAPPHIRLGGNAGDTMLYDDSVTGTALQQNANPTGSGNARPSDYYTFGPDFLKALNNFPDGTPITYGLNLAYTGADALNRVVAQAQAAFEYVGTNPNGAKIVGLEIGNEPDLYIDLGYRSQNWSVYDFGNEWSSRAEAVYNQVLKPRGINSNYFEVATTATTATKNGQPFRISNLVNTGVAADNGIYVAGWNQHDYYYYVNVSNYQLTLPILLDLSTTVSQFREWTGQVQQALVTGKPYYLREMGSVGPNGLQGISETFANALWTFNFFFFAASIQISAVQMHMTQYSIAAPWQTNYMNGQGPHVRPTYYAWAAWSQIIGATCNTRIAQVSLSNQPGAYTNRLNAFAVYRGNALGSVVMINTQPYYSYSGNPSYQNFVLSLPGLAGRTVWLSVLSADGVESTSNVVWNGISYEQSGNGQPRTVNATQWTMTVGSDGTLTVPVRDSQVVVASTFRLGRESVNTANCENLASTTPGTTGTATGSGNAAPTFKSTSGFKSDMPLSKTAIIAIAAGGGVFLIALLGLFIWCCVRSCKKSNARKARASAMLKAPPRHDDHPLLERDFADESHASYPAYQNSPGLRGWESPMTSVSHGQQVHPSQSYHNMQPEYDYAPAGYQHSPQQPHAMHSPTPQQTQQYYQQHPAYLQSPYQNYAQQYGHGQHGHGHGRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJA1</accession>
    <name>W3VJA1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJA1"/>
    <dbReference type="HOGENOM" id="CLU_018247_0_1_1"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="552" mass="61592" checksum="81403F650455CFD2" modified="2014-03-19" version="1">MTSPGNHHDELPTHNPHYSLLGSDLKLFSDAGFDMDKIHLKRNASVAQLYEDAIKKEGAVISSAGALINYSGKKTGRSPKDKRIVYEETSKDHVWWGPVNIKMDEHTFEINRERAIDYLNTRDDIYVFDGFAGWDPKYRIKVRIICGRAYHALFMHNMLIRPTQEELEHFGEPDFIIYNAGQFPANRFTAGMTSTTSVEVNFKRHEMVILGTEYAGEMKKGIFSVMHYLMPVKYNQLSLHSSANEGPDGDVSLFFGLSGTGKTTLSADPKRALIGDDEHVWSDEGVFNIEGGCYAKCIGLSASKEPEIFNAVRFGAVLENVVYDKNTREVDYDDAIITENTRCSYPIEFIPNAKIPCMANTPPKNIIFLTCDAYGVLPPVSKLDANQAQYHFISGYTSKTPGTEDGIQEPSPTFSTCYGQPFIVLHPRVYAKMLAERMEKHKADVWLVNTGWAGGKFGVGQRCPLKYTRKIIDAIHDGSLAKASFEKFGVFNLQIPTAIEGVPETLLNPATSWPDKSAFKHELNKLAEMFSTNFEKYANDVSAEVAAAGPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJB8</accession>
    <name>W3VJB8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJB8"/>
    <dbReference type="HOGENOM" id="CLU_467822_0_0_1"/>
    <dbReference type="OrthoDB" id="2556187at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="560" mass="60131" checksum="AE4B1B23492078B9" modified="2014-03-19" version="1">MRKFSFKSEPRSRHYKRQDEEGDQKHHKKKHGKHPKANKDDGTKDKGSSQSGDARDPSAQSPNASSTAKAALPASAEASVPPSPPTQGESASLAGSSAPTNGDGQRTSLPAPAVDNDVRSAQASPAGTGFSVEVLSAAISGGVVLLLVLLGVIVLWRKRRRNAVQKAGSAPDLRLKIGPPEIPGEKSVNDTAHAMDRGTKQPSQTSLQHGHVSLRMAHAQQSDHTLVDGERSKWPACDDTAAQLRRSDSCRSELQQESLSGRPELLPENGWDNIRAASPYDGDDKEIDRCLSYYMKRSTRVSLPPVELVEGGEPSMLEDKTSSLPPSPVVNRMSTRKSFVFPKTAGLLAKIRKSQIRLNNEALATGSHNDHPLPVTGFNLDHGTGSTGLMSSTMPDSGAPTRGSEEHGSTLESLSLGRAGPDIPSHWRSSTRLRRSFAGDRDGNAAIDSSPSLSEPHPAFEYNDSYENHTPAAHGSPWLGVGDGYDCYSATWQDRSPCRSSALSPRRSMTSTVRQRSATFSQCAPSRSPLFQENDADGAHAASPISARHLSQEANDVIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJD2</accession>
    <name>W3VJD2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_04150</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJD2"/>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_1"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000003">
        <property type="entry name" value="Probable phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="321"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="20">
        <location>
            <begin position="561"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="792"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS61654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1240" mass="132445" checksum="176D12B8A1A04014" modified="2014-03-19" version="1">MTQFISAVPPTADALFHKAQPAPLTHVDLLGTDGTEDRAVAKQRLVHANEQLGLALANDEIDYLVDAFIAGKGDASAALRRNPTDVELFMFAQVNSEHCRHKIFNADWTIDGKDMPNTLFGMIRNTHKLHPQHTISAYSDNAAVIEGYEATRFAPSPAAAADGLSVYQGVKEPMPFLAKVETHNHPTAVSPYPGAATGSGGEIRDEGAVGRGSKPKAGLVGFMTSNLLLDGDGRQPWEEDFGKPAHISSAYDIMIDGPLGSSAFNNEFGRPGLSGFWRTWSERVPTDDGKHEVRGYHKPIMLAGGLGNVRPKNALKDKITPDAAIIVLGGPGMLIGLGGGAASSMASGSSSRAALDFASVQRDNPEMQRRCQQVIDACTALSDAPGVIEGQVGQGNPIQSIHDVGAGGLSNALPELVHDAGLGARFEIRDVLVDDPSMSPMEIWCNESQERYVLAVAAADLPRFEAIAKRERCPYSVVGRATLEQELVVTDRLLGGTPIHLPMPILFGKPPKIARQAASKTPLRIPFDSSLTSYLPSLKSEPVKMFAEAVDRVLHLPTVASKNFLITIGDRSITGLVVRDQMVGPHQVAVADVAVTRTSYGFNESLTGEAVASGERTPLALISAAAAARMAVAESLTNIAAASIESLERIKLSANWMCAAGHSDEGARLYEAVQAVGLDLCPKLGLAIPVGKDSMSMKMAWQSEQGEQHEVTAPLSLTVTAFGPVDDIACTWTPQLRTDVADTVLLFVDLAAGKQRLGGSCLAQVFRQLGHEAPDVEAAGVLKAFFEACYTLKQLRVQKRDEGSLVLAYHDRSDGGLLTTVLEMCFAGRCGAEIFADVLAGDKADPVAALFNEELGAVLQVRAADVKAVSAVFTAAGVASNYLHVVGRVTEAQEIKVAAGGQVLMAATRAELQKKWAETSFRMQSLRDNPQTAAEEFSLIEDESGAAALRYELTYNPRDDVLGSQVVGAEMEARPKVAILREQGVNGQIEMAWAFARAGFSAVDVHMSDLVEGRVTLDAFVGLAACGGFSFGDVLGAGSGWAKSILLNPAVRAQFERFFQQRTDTFALGVCNGCQLLSQLAAAGLIPEAEHWPLFKANVSGRFEGRLSNVEITSTGGAQSIFLRDMAGSVLPAIIAHGEGRATFRAEGDLEECRRRNQVAMQYTDQRYPVNPNGSPEGVTAVTANGGRVLALMPHPERGVALSSMSWAPVHAHARGDKGWNGKGPWFRMFENARKWVDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJE9</accession>
    <name>W3VJE9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidylserine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250032_0_0_1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF517">
        <property type="entry name" value="RNA HELICASE NONSENSE MRNA REDUCING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="9">
        <location>
            <begin position="898"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1474" mass="162669" checksum="7677F1C68B78D8ED" modified="2014-03-19" version="1">MASGQHASEGAEHETLALVLEHLVSAGPVHETPDKLQPGTSDHNAITPAPISVQGHTHWWGRFFPGHMESTLDRLFAAHHMGNYVAVRGQPGKKIFESMPIYVRVGMHLLFYKSKEQSFLRYKTVEELLQTVSIRQGKVYDDESDPQAVLEHIQKFIATYSIDTAELLQPDPSKYPNFNSFFFRKLRPDARPIAEPDNASVVSSCADCRLTVFDNVAASTKYWIKGDGFTINRLIGDTNLADRSFPPGSSLAIFRLAPADYHRYHHPVGPAMCGPTRHISGEYFTVNPQAVNANFDVFSSNRRDTLLLNWTPKGAGSPVIPVAFVAIGAMLVGSIGWTNANQGASVQRGDESGYFAYGGSTIVCVFPPEAKVQWDQDLKDNSANGIETMVRVGDRIGLSKQIFVRAPAFDTIPASRLGLASHHLARHAVTSTRRAHESVQAAARPPPQESVCIAGPSRLPTASFQRHAHSSSHSGPGFGHPAKRGLLGTNDPRSVASASSTAPRKTQKAQYSRRGTDTSPRSSRPHVPDRPHPHGSAPGQWWTGETSATQADRTASDPMLDLDRQMAASHWPFGPSRPQDLYRDAYVAHPDRFDWRRRCTSQPVVRSASKSAPLQRRKASASMVNGEESKFAAKARRTAERKMDDRSLRISREKAAQLIQRNGERQPIRQQAQLYRQNWTQLLDHERTQELAAIAERRKAPIDKLVDEGIAIDGLQAYWQDDSRRHFGKKVAVFKLDAAEPLPRTLFRAGDKVTIMPSTSSGPYAGQPLAEEEVIEAEVVERQRTFLRLKFDERDEDVDLVACPSWRLDYGFNDLTFERIKAALEAIEHDVEFIETQYGSRFQYILSGTRLSDVILGIEPPADRVTRGAFWEDARVQSWYDRFSRPDPVVVDGDPQPELNRSQTQAVAMMLRERVSLIQGPPGTGKTRTIVTAIKLLKQEFQVPHPVMLAAHTNVAVDNLADGCIKAGLRVVRIGPSARARAGIDQFTLDAHFLRHPAKPRLDDIKRRMDTLEKLKSDYEMVRGTVAAPAARDESEEGIGATGGGAALSWEDVMAEREEEREVAQSQGGTASEEYESIKKRLNRLKATYFFLRASIRGEILNGADVICGSAIAAGSPELDMIDLPVVFFDEASMATEPVSLVPLMKGCRHLSIIGDHKQLPPVVTSAEAKQGGLSKSLFERLIESTAADGSKIPSTLLNVQFRMHPRLAEFPNKTFYSGALENGSGTDKIPAVESGYWPHVEGKDEAHRLCFIDHKGRESKADNSLSLCNVAEARLAVDVAMDVLRRNPELTGDDIGIVTPYAGQQILLEKMLHNDTSAERRRAAGALGARSSQLGCIDVHTVDGFEGREKKVILFSTVRTNAQGYVGFLADGRRLNVALTRAQSALFVLGNIDTFKNAQLSEAAYSRVESPDLGALHSYAEYLEKQGAVYTTTQTPRTVDVAEHDDQDVDAAETHSLADAAEWQHILAERSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJG0</accession>
    <name>W3VJG0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PaG_03874</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 31">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 31">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 31">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 31">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_1_1_1"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
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            <position position="381"/>
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        <ligand>
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        <location>
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            <position position="217"/>
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            <name>NAD(+)</name>
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        <location>
            <position position="228"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        <location>
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            <name>NAD(+)</name>
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        <location>
            <position position="244"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        <location>
            <position position="250"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        <location>
            <position position="259"/>
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            <name>NAD(+)</name>
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            <position position="260"/>
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        <ligand>
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            <name>NAD(+)</name>
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        <location>
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        <ligand>
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    <feature type="binding site" evidence="21">
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            <position position="292"/>
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        <ligand>
            <name>Zn(2+)</name>
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    <feature type="binding site" evidence="21">
        <location>
            <position position="356"/>
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        <location>
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            <position position="377"/>
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            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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            <position position="393"/>
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            <name>Zn(2+)</name>
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        <location>
            <position position="462"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        <location>
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            <name>ATP</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
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            <dbReference type="ARBA" id="ARBA00054455"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU004164"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Pfam" id="PF00275"/>
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        <source>
            <dbReference type="Pfam" id="PF01761"/>
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            <dbReference type="Pfam" id="PF08501"/>
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            <dbReference type="Pfam" id="PF18317"/>
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        <source>
            <dbReference type="Pfam" id="PF24621"/>
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        <source>
            <dbReference type="EMBL" id="ETS61778.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1785" mass="193868" checksum="A449798ED10EF55B" modified="2014-03-19" version="1">MPLHHIHRRCRGLRSHLLCIQHSYRFADPARILPTSAKAPPKAELVQTWPLTSSFRQLFAASFLTMASAQSAASQPAQPVLRTKTPSYHAPPSTDKLSGATIHTLRCLDTPIHLGYHLIPHIAKTLLATLPSSTYVLITDQNLESRCSVTTAFRREFEKAADALNSTHTWRLLTKVIPPGEGSKSREGKNDIEDWMLENRVTRDAVVLAVGGGVIGDLVGFVAATFMRGLKFVQIPTTLLAMVDSAVGGKTAIDHPLGKNLIGSFHQPNYVFIDAAWLKTLPPREFSNGMAEVVKTAAIWDPIDFAKLESSAPAIRSAVLGPFASDAPLDQGRTLDTRTESQSLLLDVIRGSVGVKAHIVTIDEKETGLRNLVNFGHTIGHAIEAVLTPEMLHGECVSIGMILEAEVARYMHGLSQVAIGRLTRCLKEYDLPVSLSDSRVTRLPRSLDVTVDRLLDIMKVDKKNSGSNKKIVLLNSIGDTVEDMASTVSDDIIRRVLSLGATVTPILEQPNNAKVTLSTPGSKSISNRALVLAALAGNTCRLRNMLHSDDTQVMMAGLTDLHAARFEFEDGGETIVVHGNNGDLRRPANNKHIYLQNAGTAARFMATVVTLVGNDGTQDPVVITGNKRMKERPIGALVDALRSNGTSIDYLEGQGCLPLAVKGTASGFKGGKIQLSATISSQYVSSILLCAPYAAEEVVLELVGGQVISQLYIDMTIAMMATFGIKVERLADPATGRLSNTYRIPKGRYVSPAVYDIESDASSATYPLAIAAITGTECTVPNIGSASLQGDARFAKEVLEPMGCTVVQTATSTTVVGPKVGNLRQIGLVDMEPMTDAFLTASVLLAVAAQPPANGSTSTARPSTRITGIANQRVKECNRIRAMMDELAKFGVDTKEHEDGLEIFGIDYRQLRPDVRVHCYDDHRVAMAFSVLASLAPGAILEEKRCVEKTWPNWWDDLERKLGIRAHGVDPECSPSLCISPSHFSKASVAKPSANGKQPASLAEFAGGRTLLPRKYSKDATIICIGMRASGKTFLGAIGAAALGRTFLDADVVFNEKLGVKDGLGDYVKQYGWPAFRQKELEVLEELMHRHPTGALISLGGGVVETEACRNILADYAKNRGPVVYIVRDTDAIVNFLSTSDRPAYGEPIMDVFRRRDPWFRECSSFELVSYSEGELLAVQPSAINVPDPSFTIQKRFGLESEVARFFKFVTGQDTNQVNDLVVDSRNAGRRTYFLSLTFPDVVPKLELIRSMESGADALEFRADLLNASGEPVTSPQLPDVEYVKSQLAALRHRTSLPIVFTVRTHSQGGMFPDGYQKEYFELISVALRHCCEYVDLELGWDDDALAAVVAAKGSSQIIGSFHDWSGKLDWESDATAKIYERACRFGDIAKIIGKANSMDDNYSLERFRTKVSASATKPLLAVNMGAAGQFSRIVNPVFTPITHEAMPFKAAPGQLSFREVQNALTLIGKTEPQQFALFGNPIGHSLSPLLHNTGFAALGLPHHYQLLQTREVGETLDAFVHAPNFGGASVTIPHKIAIIRLLDRVTDEAKAIGAVNTVIPVRDAMGKVTSLVGDNTDWIAIETLARRSLRTVHLANPKLTGLVIGAGGSARAAIFALYRLGVKRILLYNRTYANAESLVRVLPVEWNVEVLSSLDEIAALAPEEAPSVVVSNIPAEGTTLDSAAKGLIYLPPSILRNPAGGVAIDMSYKPYSTSLLQLAQQVNTQTELAIGTNTTKAPSRKLWSTCPGITILLEQGCHQFKRWTGREAPRAQIEHAAWEEYLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJN3</accession>
    <name>W3VJN3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TFIIS central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJN3"/>
    <dbReference type="HOGENOM" id="CLU_1555962_0_0_1"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="6">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="175" mass="18811" checksum="004B0E0E861FDDF0" modified="2014-03-19" version="1">MPDIRQKSVDFLSDSIAAATGGQAADSAAQQLEQAIYDKAGQSTSNDYRGEVRSIGLTLKKDNPQLAQDVVQGRIAPTDLVNMSQEEMKTEKQAQEDAELRQQNLDASVGVDELDPQYGTMATSQQGRSRMQEEATYGEAGEASYDGGGEGEFKARAQPKVGEAMRGIEFETGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJS3</accession>
    <name>W3VJS3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor cys6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJS3"/>
    <dbReference type="HOGENOM" id="CLU_006017_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="903"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1169" mass="123683" checksum="C569463D1FF28EDC" modified="2014-03-19" version="1">MPSSPHPYRSAAHQLQHPEHASFSPSSRSSPLYTSASRKSHAAYRNSPGASSPEVFSDMDRAALPSAHISASRPYNASVDPSQQQQRPSPSKRRKQSSDGAELHASSSSNTAKTPPGESAGSDGAADSKPSTRVAKACQPCSTKKRRCDGRQPQCSVCQVLGTPCTYNHTGLKRGPPKGFRSGPKESARAKLIRTLETTIRDLVNHLGKDDAGAEIVRVSGERELPISNAQALAAGSGLGDARASKQSASAAKKKGAAAAQVKVEEGLHPRRHPSGSFEGSNDVGADVDPAAEAEEDVIGETRQGEIVYRGSSSGIGILQRQHRAESPSPAIAASRSVASGSSAPFGGRSRDDRATADLASHPKPPVFLPISSPHIAGDADTTSSQDRSPGRSGPSQRKDSSNLHSLYPDTSRDGQMSGSSASVQDPVVSVEENDRLFRYYWQGFHPFYPILYKPWFMGFSGEELRASLEPSLLYAIYSIAACVVPANAATKSDQGRPAADALNHERAQSFCQAAERHVLAKGLRPDIASIQTCWLLSLYSHGTGDLSRAWNFQNLASSMAVDMGLHRWPIYRAEIVQDRVQRETRIRIIWHCYILDKVLCAEMGRPVGLRAKDIDVPLLSETEEDEFELWSDQLEMQPAGASSSQRGVATANAGRRLHAPSCLNWGVHLFKIVERILDEVHSLRRKALLRRQGKEQVLAELDHQLTEWKEKLPAHLHLDDSPNEGPFPSFFALNLWYYTGRLLLHRPFIPQEEGLPMSTVLDNDSHRQSTLAANTICDLLEASARDIVDRLSTDLGYCLFTAAVMFVFNARLPDARIASDARRRYGLCVQWLKKLADTWPAASAHRLLLDGFAVVGEDASKQGGDAPQRRASIAALQAANAGSGMAATSKVSSWIAETEGALQGSSSARRAQDGAAKDERATTSSQDASAMSNANGAMGPGGPGVPIFDESWSKGSGAFGGGGGPVSENARQLNAPSSLDFAPGIFDVESFFWNENATATGLMGMNFTPLPGNTPTGSSHGLNSNVAPAPSPGMGYGEYSGGIMASFGPTSAMQGAAGSAMAYANMQYSQAGRGGAQSMAPPAAPGQSRQPAAAAAAGGMYGGAGTASGVLGVSEGGAGVVGQPGGDAGGSGTAGAGMPTSPFAFNPTAHNIGEFWSMLELPPAFLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJT3</accession>
    <name>W3VJT3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJT3"/>
    <dbReference type="HOGENOM" id="CLU_023807_0_0_1"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000301">
        <property type="entry name" value="Related to triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="352"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="713" mass="80466" checksum="DD2FBCF73AC7E7BA" modified="2014-03-19" version="1">MLIPSHSNLGRRGGQAGLASAAELSPDPWHKSTAASRAHVLHQGGSGGGGPRTSLAASLPVSLRKQLAKDRRFAPLPWRRPSSNRARIAARHPLARFQPRSVPLFPSLLPPSILPPSIGLAFPVVARSGRRHRLSRHPSAYHHLGNGHMSSGFIDYSRRRRASGPASETSRDAASQRGGADPFDEQDARPRDHLDTDTEAESAAVAQPAQPAPRQQGPFDDASDMESAHQQPRSRPARVEIMGDPGSRPYPHRDEPAFFDPTFPNYQDEAPLEMPFFDHVVADYGNYGTFQRLRLNFRQMISFFASTTALGSVLFVAYFAYFNPFKKSPPKAKTDREYERRITGERGSGRPAYYAEFWGYQCDEHEIVTEGGWILKAHRISDPRRGGAVGHPVVLQHGILCNSSHFIVNEERSMAFWLVDQGFDVWITNIRSNFKAGHTEYTRSDPRFWAWGLKELAFDLRDVVDYITAATGRPQLAYVGHSQGSGSMYLALSPGICPEIGDKLSCFVALGPSVYAGSVLRKFPFSLLRQFRSRKWWGLVFGVREFMPAIGFAQEFLPAFWFGHIAYVIFAFLFGFHDHNWVSRQKPKIFRTVPVPTSSELLYWYMSGFSHRGCIFDPRITEPWFPRTFPPHSIFYGDIDFLVLGKPLVQRIQRYERNVEMIHTVELQNYEHLDMIFGVDAFRTVFPGIKDTILQTIDPEDLAPEMSERGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKA1</accession>
    <name>W3VKA1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose 5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKA1"/>
    <dbReference type="HOGENOM" id="CLU_091396_1_0_1"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16865" checksum="8AAF4F52B5316F28" modified="2014-03-19" version="1">MAAPQKWKIAFGCDEAGVDYKNALIKDFQADPRVESVIDVGVPSNADKTAYPHVAVTAARKVASGEVDRALLICGTGLGVAIAANKVNGVRAVTAHDSYSVERAILSNDAQVLCMGQRVVGLELARKLAKEWLGDKFDTSSASAAKVQAICSYEGVADKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKC7</accession>
    <name>W3VKC7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKC7"/>
    <dbReference type="HOGENOM" id="CLU_352729_0_0_1"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF23">
        <property type="entry name" value="DUF726-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="886" mass="93436" checksum="975761EE947586A5" modified="2014-03-19" version="1">MFSKERAKPSSSSLDLSSLQSYSPGWSPHLRLATCISLKYAVQRHVERATALSRSASASATSAASGSPFYSASQEWSDYGDKFLTATCQHLGISESSLPPGPIGLEDVLAAAHGRLEHADTRDPICQNEPQFESGSDHARRFPNLDLPIKGVDDVKKDQLDASTSAEKADADDHAVSLDTLKLESSATPSSPGSDHGSDLFSYDQDAQELPDYFRNREEASEPSQTSSADRRRLQRARSLSTNTLASAGPKRVQGAIDPGSGQEIEVAHELLLIALGLGQYRAQDGTSTVFEQDFLFGDTQLDLKGAEVGNSEAKPAKPPALPPRPQRGESSETISTLASESPAQVGSNDANVARSAGDPMSKVTETGRVLGGASISAFNSLKVGTLSGWNKLSTASKELVNPQASANPETKLANKDAKQPVKPNEVCHYDARARSLVFVAVTAMGIPGRQVWMAEKVMAQTIYFIMSEGDKASASKHGKGIVEQLPAGASLDARTGSITQASQRSEYMNQHSGSVVQREREKVSWGKWAAMGGGFIAGGLVIGLTGGLAAPLIAPALVGLTGASFLATSGGIIMLGTLFGLGGGGLAGYRVERRLRGVSSFSFAELVTEARKAGVAIPSLHATVCCSGLILENDQQVVPWNHVFEGAKDGRDAFAIECEAEMMRLAGQGLRSYVLDNLIRTGGTKAAEEVVKKTALAGIAAITLPMTVFNAASATLDGVFVRAKTKAHKAGLILAETLRNEVQGHRPVVLIGTSLGAATILTALTELAKEPEHTSHLIDSVILISAPITPSGATLRKVRTIVQRRFVNVFSSNDMVCGIAAWLGSGVSVEELRAGKLPRVAGSRAIDDVPGLENINVSDILSSHFEVNDPDKLSAVLARCGALDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKH6</accession>
    <name>W3VKH6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKH6"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="578" mass="61555" checksum="7A6110F9BB406FF2" modified="2014-03-19" version="1">MTTPTSEQATENGGSRVSSISNIKRSSDKDVEKKTAPVSTESGGELSKLKVLSILIMMGLLMFLVALDKTIIGVALPSISNEFHSLKDIGWYGSAYMATNAALQLVWGRVYKGNPVKPIFIAAVVIFETGSAICGAAPSSKALIVGRAIAGAGGAGITNGLISIVMAIVPLEKRATVQASMGSVFGVASAMGPLLGGAFTENVSWRWCFYINLPFAVVALVPVIFFLDGSKTADKGKTMLPFREQIRQIDPLGALLILGSIVCLVLALQWGGQASSNTELSSWNTPRVIALLVVFGVALLAFVAWQMYMQDRALLPPSIFVERSVLGSFWYMWFFAGSMTVMFYYVPVWFQVVQGVAPIQSSYRTLATIVPFVVASILGGLVTKKTGYYTPPMLLPAVLGAVGVGLISTWNPDASRAAWAGYQVVYGIGMGAAMTGSSLAVQAALPHSEVPIAIGAVFFAREMGSAVFVATAENLLSSQLVKGLQQVAELRDGSVQLAQSGPSQIRSVAQSLGDGVLEEVIGIFNAALRHVWYLALALTLATIVPFFLIRWLNVNEVAKERAAEREAAKVEVQKVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKH8</accession>
    <name>W3VKH8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CLU1</name>
        <name evidence="3" type="synonym">TIF31</name>
        <name evidence="6" type="ORF">PaG_03616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003256_2_0_1"/>
    <dbReference type="OrthoDB" id="771227at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="5">
        <location>
            <begin position="361"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="715"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1009"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1411"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="715"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1417"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1427"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1438" mass="156341" checksum="8BBCE49931D68BF7" modified="2014-03-19" version="1">MAQEQPAEEPPQPPAAEVPEVDESLQPFDINLYLPKRPLIPSAAASQNGLPETPSPLKVAVTPQETLNDLRVTITDSPEGYWLGAFCFRKPQPGAAPTAKGAKVALGERVSEWTELREVFQDVPKDQRELYVTHVPFNEADARAHVQRLRDLLSGGAADPSAIGVDAALSVQDAVRNPEEWQHDSSRQNANGRNASKKGADATAEAASTESQLPFIDWAGWPAVTAIDLIPAVARRPRQLPLCLRQLSLASWNPPPQHCKLNGHLLYLQVGTLEGEVIFITASTHGFYVNKSSGARFDPSPRASGQDFASCSLFDLLCGFSPLFLASFARLFNDPLSSRDYFSAVPVTNSLPAIPWLARQHPHSPDPLRSQTAFLLTGASSADTLEGTRDWNDELQSARELPRTTLPERLMRDRVLNRIYSEFTQAAARAIPKVAAGEVQAMNPMDKRDAQMFIVNNLFISKGADGVDLYPHMGGDEAAHVAVGKDIQGVKTLNSLDVSGLCLLGTIVVDWKGERWVAQSVVPGLFRRRDDADAELEDGDANTAQETEAAKEEPKAENPTDDKAAAAKSPRSDLNDDTQVVYGGVEGPEVIRDNAAFHKLFRQVAQTLHLSEHDVEDANGRTHPLWLSVDSKGLRGADGRRYVLDLARLNPVDINWLEKDIAGAIHGSESSSSSDDKARYPHRMTLLRPELLEIYWDSEFRKWARAKLAERQEAKAAKASEAKAVEGKEDAKEEGADADKAEAEAEEEPERLDSSEFKLTFNPDAFVEFKVADPSVEDGSKVITPITDESDASIAAVRQASDFLRKVAIPRFVTDVAAGLFTAADGGALSRQMHARGINIRYLGYVARLCAPEAKSELDQELISKAGPGHEGFLHAFRSTVLHEMVLRASKRVLRGLVRDVEQVNVAACVSHFLNCLVGDKVNAAPQSQPTSSPLSDASEAEWTQLTPESLKQKLVEEIRKRYRFELPLSFFDQELRRPQLLREVALRAGVQLKLQDYVLEGKPVEADGALSDDSHGEVQANGNAKENGAGVSGKKNKNKKKGSNGELNGSKKTAGSADKKPIQAARTTSFEPSDVLNLVPVVKDSTPKSTLAEEAFDAGRLSISRGDRDLGLELLLEGVSFHEQVYGLVHPEVARCYALFATIVHHLAGVAAMERAEILNQAKAENKEVSEADLPAVNEQVSMANAVRYQRQAVTVSERTLGLDHPETLNQYMNLAVLERSAGNTRESLLCQRRVLELWSLLYGQEHPDCINVLSNVALTLQNAKLFEASLRVYESAHQLALRLFGADSIHTANLAHELSQAHTLVGDLKTALTVEKEAWRVFEARLGKEDAQTKESETFCLNLAASAVRVAKLEKEASAREARQGAFGLPNARRVGANATANGAATTGAIAGAAPGGAPANANKSLDEIVRFIQGGSSTPSSTKGKSKGKGKAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKI3</accession>
    <name>W3VKI3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKI3"/>
    <dbReference type="HOGENOM" id="CLU_2224348_0_0_1"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11256" checksum="A2D78B023C319748" modified="2014-03-19" version="1">MAPKVRAAPQEVSLGPNVGEGELVFGVAHIFASFNDTFVHVTDMSGKETVTRVTAGPVPFAPPPLPLQQCRPDHSPTHLTSLPVSARIPALTCAPYLPISTFNALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKJ1</accession>
    <name>W3VKJ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKJ1"/>
    <dbReference type="HOGENOM" id="CLU_048353_0_0_1"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF53">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="222"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="355" mass="40500" checksum="C429F71BA14EDBE7" modified="2014-03-19" version="1">MRDAVSRLFQWRLGSQGRVAEAFCEGTHTPTADDGSALPHLLADILHVEGPRLLFRPVLYRMQAAREMPSTEHEVTLRIPSAQTGVDIVGILHHHYSTQQRTSDVALILHGLMAHKNQSYHRELAVALPMDSFRFDFRGNGETGGAWGMCNIANDIEDLQAVVYHLRHQLGYRIELIIGHSRGSLDAWAYIGRDERLRWDDDTDVPYLVAVSGRWDMPRVLDRYDVYKPGFEKEGVFRWRTKSAGVQREYPVYPSDLSRMASFPIRSIVKRLPLNTDVLLVHGTKDRTVPVQDASSYLKELSSIPRRSHDSQQIQLIHGSDHMYKGYTHDVVERILGWYRQRKAAKATAPAQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKN2</accession>
    <name>W3VKN2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKN2"/>
    <dbReference type="HOGENOM" id="CLU_029722_0_0_1"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="68222" checksum="A90F8E322B435915" modified="2014-03-19" version="1">MSSSGADAAPAPVATNDKDATADELAAPPEAVQMTDEEEMGAAADKDQSDSGKLKTLMGILKRMVGVKDIAAIRISLPANLLEPVPNLEYWNYLDRGDFFTLVPDLDDPLDRMLAVLRFTFTKELKYVKGKICKPYNSILGEHFRCHWDFEPAKVTDSHILPVQSLAVEAPEPLPLASNQARTPTFNAKKGSAPPSPLVTPQDQSRPSSVRNLSMETSNNSSSNNNSTSSAKKGLSKLLGRKKSTKDASEAANAAASSAHAAGASEDATDNANDAASVSGSSTQRAGKRRLCFLTEQVSHHPPISSFFCEAKDAGVSHHPPISSFFCEAKDAGVQLYGVDQLGAKFTGTSVKVFPGEQNQGIFLRLTENAKCGAAGEEYQITHPTASINGLLRGSLWVAICDNLYVTCRGGKRDKGEGDDGSRLRAIVEYKDESWITKAKYALEGVIYSYGPNDDPEEYTSAKQVPQDKVLATFEGCWKGKITYKRKGDKESRVLLNITDVDPISKSVRPLAAQEEMESRRIWEPVTNAILGKKYSEATKNKQDIEQMQRNAAAERKRNGETFVPRFFDADISDGRPKLTDEGRKAIDGEYQLAGYDGAADDKVATVNAGKAEDADEDDEDDFQDAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKN6</accession>
    <name>W3VKN6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKN6"/>
    <dbReference type="HOGENOM" id="CLU_069054_0_0_1"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="224"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="330" mass="34381" checksum="D1696678E4E80281" modified="2014-03-19" version="1">MSIVPASTSLAAASRAARLSFLYPGASSCTVSTLSRTYTTRSRRRATAEHLRQPSSSRHVMPSTATAAAPRWLSTPAIPSTSTFSSRAHPAPASSPSASSSRLAAWRSFGSSSASSKPSSDPARASSSDTAAVDPACATLSPSSPAAPKSQKDPRAPTPSPATPAPTAADPAPTTNLTPSKAAELASDPSVAATMPQATAAATPPPKKASSDRGTKFRSRTAALKLTPTAVLRLRALMDSDSGPKMIRVGVRNKGCAGMSYHLEYIKPQDAGRFDERVKQDGVEVLIDSKALFSIIGSEMDWQEDRLSAKFVFNNPNVKEACGCGESFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKN7</accession>
    <name>W3VKN7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04394</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKN7"/>
    <dbReference type="HOGENOM" id="CLU_010811_3_0_1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="216"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="670" mass="73648" checksum="9E56284871DC2AC8" modified="2014-03-19" version="1">MMNHDRDADRAGLLGSDSDSHSQNAGSYSRPFRREPAPGLQHSNIVQPGRGTAANPTSTFHSTSTGSHSSNSGTPRFLGAYNAGARGSSSDVSVHSSQFSSASSFTGAKGGYASDEKTALNRRGAAGRTAAPGAAALAYESDDDDWLHDPSINDHRKLPKSDMHESITSMRGILNVGTLLLILGCLLMLFLGYPVIIEISKQHSDGTASSSLSTTNTYTTFPSEMKRGLIDQQTPQSAYKRTSAVDDSKWHLVFSDEFNTPGRSFWPGEDPFWEGFHGWYSGTNDYEYYTPEAINTTADGKLQISFEERETNNLNFRSGMLQSWNKACFTGGYLEVRAQLPGSPDVAGFWPGLWLMGNLGRPGYNGVNEGIWPYSYAGCDTGALPNQTWVNGSGPAHAINANGQFSYQVNHKLSYLPGLRFPACTCPGEDHPGPNNNVARSSPELDMLEATIGANGGQSSQSLQVAPFDVDYFYNNKSGTDYTIHNTDTTKINGYHGNELQESVSALSAIPDRAYQRYANPQYVNFGVEWEPDMNGDGMGLNGEPAYITWSIDDKPTWTLRASALTGVPELDISRRLIPREPMSIILNLGMAYNFQPPVWDQLQFPGTLKIDYVRMYQRDGRADRVSCDPKEFPTRSYIERHKDVYSNVNITRFPKDRIPKNSLTHPGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKN8</accession>
    <name>W3VKN8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKN8"/>
    <dbReference type="HOGENOM" id="CLU_038085_0_0_1"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="347" mass="38332" checksum="FC1716519A74DB9A" modified="2014-03-19" version="1">MAPQSGPIRQASHAGSWYTNDRAELDESLTEWLSDVKADQLPSPLAVCDHNPRSGSLPLPIPTCRAIIGPHAGYAYSGPAAAYAYKCIDIAAIERVFILGPSHHVYLDGCAVSRCSQYATPLGNLEVDRQVTEELKATGKFETMTQSQDEDEHSMEMHLPYIYKVFEGRPIRIVPILVGAINTKTEDVYGKLLAPYLNDSRNFFVVSSDFCHWGTRFRYTYYKPAEDSPASMLSARTQRSAYEGAPIHQSIRALDEQGIFAITYPWTQGGESKTAAEARKAFAEYLSSTKNTVCGRHPIGVLLAALAELEKAAGIKSECRFTRYEQSSQCTSPQDSSVSYASAFVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKS9</accession>
    <name>W3VKS9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_03725</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKS9"/>
    <dbReference type="HOGENOM" id="CLU_008640_0_0_1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="261"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="863"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="797"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS62159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="967" mass="106453" checksum="5D91CED02407AB1B" modified="2014-03-19" version="1">MSTYSAATRAAAQRAGHARTASLASPIHAHARHLRQPLTRFAARRPGAPDALFAAHFTASSSGSRLMHVRAISFNSVPKAAFRVVRLPAYGLAAGGGALAYANYKVDEFKDMLGRSYGRLSDRAKEAYSGISELGADALENARDSWEALSERLDAIELPDTPGFLRNLFSGFSNSQSSQDASGASKWSAGGGSGGPDPNGTSAMAGAAAVVASSLFGDDEASTDGTADTASKTSTEELMLLTRKLIEVRNILKDIDHESDQLTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGNNMVTRRPIELTLIHTPAQPGRATKDTLVEYAEFPGLGLGRITDFSHVQKTLYDLNMAVPAAECVSDEPIELRIHSPHVPDLTLIDLPGYVQIASMDQPDELREKIQTLCQKYIQEPNIILAVCAADVDLANSPALRASRQVDPLGLRTIGVVTKMDLVPPEVGAAILSNNKYPLSLGYVGVVCKNSLGMFQSAQGHDRAGQGRMASMVTKQESDYFNANREHFKAPARGRNAGVEPMTGTDTLRRRLMTVLEESMGSSLHGIANAVQVELEEASYQFKVQYNDRTITAESYAAETMDALKLRFNEFAAHFGKPEVRALLKHALDEKVMDILAQTYWSDARTPELAQLADARKLAPDQLDKYWQYKLDASSSALTKAGIGRMSTQLVVDAIRTQIEHLARSEPFNHHPEAAERIVAFSSAILRERFGLTADQVENCVKPFKYEVEVEPAEWEAGRQRSVSLVERELDMCDAAFNGIKKLLGGRRLKGAMEYVTHMEERERRRVQARLRAREQADSSDASMDEDDSNDPTRPDYNSALLIKAREALFLSERSRMLRTRLGSLRSRRCKTGPESKAFCPETLLNIVAEKLTYTAVMFINIELLAEFFYQFPREIDAKLMHHLDADQLAAFARENPAVKKHLDLQTRKHKLEHVSSVIGELVKVYKQKNSASRWAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLI8</accession>
    <name>W3VLI8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLI8"/>
    <dbReference type="HOGENOM" id="CLU_009332_0_0_1"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="6">
        <location>
            <begin position="298"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="951"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1116" mass="121998" checksum="522D5097EFA64201" modified="2014-03-19" version="1">MSESKKITMEQLKEHNTHEDLWLLIDGKGTLPRNHLQHRQHRDLRARITKASTERWHSDALRDRDLDRLLGWIKFLDEHPGGDEVLVTEAGKDATEAFEDVGHSEDARALLGPMLVGELEGGTQKIKTTSGAVTNENNTNLNSHPLFMFIPLMLLGAYLAYNLDPPAVQNRQVALGPNVQEVEFSSPPERARAFFPANSTTTVSTTTTTTDAFSTIGTVASANGGAEGNKPAPAANSSSNAMTGASPSRSRANATAFLTSPSKRATSDHGRHDPKRHRSTAQSSQDPASLPEYARRVIIALDLDAFYVSACRKRDPSLIGIPIGIQQKALVATISYEARAAGVDKLDSIKEALKKCPDMVLVNGEDLTYFRQVSSQVWRLVRSVVWHKRVEKLGMDELFCDVTEMVDHHLATAAKGRRYFDLHLPDAPDKDERYGFEYEAWPNEGPGHVFPQAASDHLNENRPDWWQERMLVAAHLAFYLRQRISDEVGLTCSAGIAPAKSLAKLVGALNKPNQQTTFAPPIASSSAGRFIDAKMQEARLLHHITEFLDPLDLRKLPGYGRVVVEKIRDHVHPEATTTAAQRGPKVRSNFMEPANVSDEETEGAGEAAPSTPGLTVGTTRKMLSLQEMVDLFGDVTGPRLWALVCGRDAEPVVPAPDFPVQISIEDTYPYPSLRGAAIHSEIYRLSLSLLRRLELELVLSERNSSDSGSASQPVDVPTDSGVVRDYKDAIPATASKPVKGKAASWVRYPLKLRLSVRQGWNNRVSKQAPMPVEVFELEQPREVRAGAMAKACKTLLRALIGGDDVVGDAMNLINIAALELSEKRPQRALVSFFASASAGTERSIGASFRKMPEAEAKTGEIDAAVLASLPAELREEIMAEYSLGASLERDTGLRRADRPWMVAPVQGDDVDDGTASLRCATCGEAMEVWMQHDHELYPLLGLPVESSSAHLAARSRPSSSPPSTLISSQSVDDGGQDAVVGSPDDDSEQDEELEQCKLCGEALRPWMLTAHSRLEAADALSGVATALKKLSEAERSAPQISASFHLFQTFFRLIFADRVCSEAVRRRGCLTADDERGQALNAFGSNAGRIPAAATWTRVDTRTLLYRRSGQPTDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLN6</accession>
    <name>W3VLN6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide-binding protein-like 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLN6"/>
    <dbReference type="HOGENOM" id="CLU_451309_0_0_1"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01849">
        <property type="entry name" value="YlqF_related_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanine nucleotide-binding protein-like 3 N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="609"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="658" mass="73169" checksum="1CE4D6EE9E55534C" modified="2014-03-19" version="1">MVKVKKRASKRVKIAQREKIKKKVKEHRRKTNRDERRSTQWKSKARKDPGIPNSFPYKEQLLNEIETKRRLQEEEKLARKAEKLAERNNGEQNADEPQDGSDVEGAEDSDEMVDEDALDDMPLTAPLYRGTLQELLASDEIKTIVLALDARDPQSFRSPWLEAAVGKQKGKKLALALSRADMVPLETVAAWTAYLSSSTSLPVFPICAPSDALPENTGAEALVEKLALKGVKRGDVAVVGLAHSGRSTVADAILNAIGVPEDEDVEDEDNETSDWPAVLDTPALIPLKSSEAAEDSDAEEDEDEEEDEEDDEHKLMARMELKSMQTLMRNQGHVQRIKEPLPLTWSLMSRVSHPEDLMLIYNVPAYGSFQVERASLADEEADAEEAEKIQAAARRQKVHADTQEFLIALARATGRMKKRNIPDEIGASRVLLRDWSHQMLGYYTQAPKLGDKALKASEETKQRVASTMPLVLPRKEWRKKFQARELRLKPISAVLGREALVLQEVEMLPPPPEEDSEEDEEEIDEALLEAGDESFDDEEEEEDEEGEDEDDEAEAEQSPQKLKSILKKNGGGSKKRSGESASDDEADDDDDEQQLSRKERRMNNKKARVVVPSKSKPTPKRSSSAKSSSAKAAVGAAKAAAAATGPAPGEKYDFGAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLQ5</accession>
    <name>W3VLQ5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLQ5"/>
    <dbReference type="HOGENOM" id="CLU_345857_0_0_1"/>
    <dbReference type="OrthoDB" id="2546488at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="817" mass="87680" checksum="4DBA2362CAF607A8" modified="2014-03-19" version="1">MSEAGTEAAVSCPLTLREQLRLKAQQKLSEQASTSASAGRKPATSSAALAIDDDDDDDALGSLTLGRSKRQAALKRPATYSIDPTDDASRLHRHPDALAGSVAHHASSSRRYASVDGMLRERQRKIKRGIDADGFSRAEAIARSMEQERLGRMGIAYSDDEELTDIRVPGASKTGTSSSRPKSSASLEPSRQAGPSGSRTNGHAPEPTVQALSPTIPSFVWSSQSELGDSEDEDKRPSAATPAPDIQKKRLAASLAAVGADEDQSREALDILQRDMRDEAFRPADPHGGRIPFYRPGKTVAPVIEAFCEVPNLGVADEVADTASTTRERIWTATYPHILLACAIPPSLQVRPAELARIVTWTAVTCLLERDVLQSQLAFGLLESLVLQPDQSAYRNELLGAVAQAAGDVLALVPRVLHRIGVSESVLVECFPDDADATDGPFFVVTRARPRMHDRAPSSSQTAKVEQARRAPRSALYLTHAECDELLAHLARVVQLVVQANSSTVRDGVSLLAGWVASMALACAAGTSVALDAAMGQGMEVIFAAAAETAVLEELQEAVARRLFTALEPESVVVRARVVQALPGAGRGVQALRAWLGWCVLTEHLASPAKVDAVVPVAEPDAVPSSDPIEAEGEADAAAARLRRDSAYWRRARFEAWSLDLHLLSRAVDANDPKSPFHVASSNADDSDADLSRLIAAVHLLALVLRDLPVHLCTFTHDARTPTKSDPLGQRSSASLPRALSLALAAYASVNPTLDEGRVQEVRTIVTRLDQANARIRDNRADVILRTLAKDALHRTSLALEYQLALYHTDSSPSFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM67</accession>
    <name>W3VM67_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM67"/>
    <dbReference type="HOGENOM" id="CLU_460127_0_0_1"/>
    <dbReference type="OrthoDB" id="2552507at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="593" mass="63062" checksum="95CE4A13FC0E81DA" modified="2014-03-19" version="1">MMHRHFNRHPATETALESTQIGPALTSPFIYALPAADPTMIKHAAPQHPQALTKLQHRLLYESDSDSSFDLTFSSPSSVGSASEYSDVGYQSSARSRTSSYGAARRMGRHSSASRSESISSVLGSSIAIQRVLMGHNSSSSVSSKNQRQSVRAIASAFEQVGRGPTADLPKVGRRQLDRVDEHVASNAAAGQAQSSRPQQPSAPAAGQSADAPTTRRAGANGPVPARLVISKEPIRGPLSAPAVITAPASQASSEPHFTFPPRAGAPRHTPTASPHVRVRSFISLGERDDDEPVFDIIPSPSRKRSFGLPPASASTTPQPRTDTVPHAPQSASASPYDSPRSLASRDSMISTYSNDSLGEHPFSLQLPTDDDAERRASAAGSLHFDLGGFSSPCMDAASTGRLTPLRSEHAAHAALCADEGSTRGSRATLQPLFLSTSRPSSSSSSATLAASSTATVAPCMRINSSTTFPLPPTNLVKSAPRSIREMRWPLGQTRDLGAESGADTMLAVDELRREAQAILDSIREVGEEIDRAIPPTHRLPGSGYREKKAASPTAAETPQTTSFVKVDQSYSDVWRIIDSWYWSSFEVGPSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMI8</accession>
    <name>W3VMI8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMI8"/>
    <dbReference type="HOGENOM" id="CLU_303285_0_0_1"/>
    <dbReference type="OrthoDB" id="2555328at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="477"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="897"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="982" mass="104993" checksum="22995BD75A1FE8F6" modified="2014-03-19" version="1">MTSPAPAYVAGAAYSGSDVAASSSYAALPGPSASHQPRRAVMLKGPSITSKTYFVPLPATLDQLVARAVELFPMPPGKVPHITLGADERAIVLQESYDFIRDRELLFFRWTAETPRRNLANRVRWDQPQSSASATPTSASASSSSNVGIEDALPSAVVSAAEALKAQLQGSPSAKRDLAAATRANTIANRDPSTQFGEGAAARKAHAQRVLAEQQRKRDEEHTADALGAAPVISEEVESDIIVDADPEAVAKAAFELAPNLPTVSPTQYPSGDTEAEQPPALDASKERSVASEPSELQTSTEAVTLEQAVQPSSSEVELGQLVHASAADVMSIESPPRKKQIDNGGLDTPPSSGSRSSSPFHSSDRASVDHRARVGADDEPSSSPISSPSRDVSSRHKHLINVAPIPELVHLPAVVLSHESEASHMALTDSADSTDPFAMQVDAHAESTAEAATAEGDAASASPTELVATKPRDGQSDRELNRIYSFLSNLVSQLLSHKANWAFQRPMSVEFEQFAARSSRPVDLFTIRDSLAARRYGSQHLEGRMAANAVVTEFEDDLSLLYSNARHFFGIRSTQAECVEHLEKFSRSFLNEYKRTQGSAPLPKASWGASSDLASARLSAFRSPGSRPEEHAAPLPSSAFSMLLTPRSNLSTPASSSAAKRTVGNNAQSANATALGMMRRPDFGFARNVSYDSSMAPAKRAQPTMTTSEAFEKALRAASATPQSDRIKPRQDTVAPFPTRSVIESDFMTRLPLLSHEQAEQQTAAQTTPSASGKRQLFSTAEAEPEATRPRTPSMSPPPSPSPTKRNKLMVRQKQSKSTSRRNKKRSKNAKAAPAGTSEQDPSDADALVEAEEESSVAGLLDAEPARKRGRTTKAARAIDEPEPVIKASKTKTTHASSPAPEVVVSSTPSTPGRMLRPRKSTPSTNEHDSIPPPKTPPRSCKKTTIPKAIVAAVETLEVEGFEVIASTRRSSRQRKPVNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMY4</accession>
    <name>W3VMY4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMY4"/>
    <dbReference type="HOGENOM" id="CLU_022829_2_0_1"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="7">
        <location>
            <begin position="248"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="575" mass="64764" checksum="45E3015348E5C9AA" modified="2014-03-19" version="1">MSTPLDIDAYRQSVESLKAQEAALRYDHDALLHMTEDEARANAIFTRLRDAEVQARWEKEGDLDNFAGMDFYGARQNGLGHHEPTPVWDAIHRMPKGALLHCHFDGTVDTRFLLEHARNTPNMAMKADRPLSSPEALWKATVEFLVLPSTQERAATSIYSDEYVAGTWVSFHTARETFPYPHPYLSEQYDQESKLPNYLFPSSSSASASKTNGHAAERATFDSGLSFEAFAHALMTLTPHSAAPAIVNSKQAWAKFQSTFGVIAGLIGYEPTLKAYTKELLRSHARDGISYTETRINFLTEFMVRADGTPDLNHEEWVRIFIEAVNEVKAEITEGSFVDAKIIYTTVRFVDNEKLRWYLEDCLTLKKKFPEWIVGFDLVGHEDPLLPLKVYIPELLRFQQRCKEEGVEIPFVFHAGETLEDGGDADLNLYDAVVLGTKRIGHGVSLARHPMLTDMVKERDICVEICPISNQILGYTASMSSHPSLLALLHRNVAVALSSDDPSIFENFGLSYDFYQLAISSKSTSLVSLAVLARRSLKYSLVGEKTKATMLADFEKRWNAFLAWFLLEHGHVLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN69</accession>
    <name>W3VN69_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN69"/>
    <dbReference type="HOGENOM" id="CLU_1019845_0_0_1"/>
    <dbReference type="OrthoDB" id="10516287at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="273" mass="30154" checksum="495C904D132C361A" modified="2014-03-19" version="1">MAPVASRLAGGAPPGTIRFRRFLSKYGLSVTAVANAVVVEAHAKRLARTLKEIIEDQQRSGGTVVKHEAGQADTAEAAAIFGLPGTDIISKVITVPHSWTLRSSSPYVVPFDAETKMSFVGKIDTITRGGGSPPECVWVRVKLGWGDANVMVFFVPSHTKLYQYVAEKMVFEADSLIYVKDLVPTHFDNADVLQFTLDSTIKLIRSDKTSFDDISRFNARLNAEWSGLDIDTLEFEEDKDDDSDDSGHDTDDLEVVPKKIPRTHSLRRVRFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNU9</accession>
    <name>W3VNU9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNU9"/>
    <dbReference type="HOGENOM" id="CLU_1644988_0_0_1"/>
    <dbReference type="OrthoDB" id="2556538at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834422" evidence="1">
        <location>
            <begin position="25"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="164" mass="15094" checksum="AE51B710EB674484" modified="2014-03-19" version="1">MQFNKSIIAFQALLLTVLIAGTQAQFLSDVTSALGGVGQTIASGATSVFGDATSGAAGAFSTVTSGAGGAFTTVTSGAGGAFSTATSGAASVATSVASGASSVASQGTSGAGSVASQASSGVTSATSRASNAAAASTINGMPVNALAATFTVLLGSAIAGTLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNW2</accession>
    <name>W3VNW2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNW2"/>
    <dbReference type="HOGENOM" id="CLU_041217_13_0_1"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="217" mass="24369" checksum="3AABC37D20959793" modified="2014-03-19" version="1">MSAENQEIPQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLQFHTNFGTICFNVWDTAGQEKFGGLRDGYYIQGQCGIIMFDVTSRITYKNVPNWHRDLERVCENIPIVLCGNKVDVKERKVKTGAVTFHRKKNLQYFEISAKSNYNFEKPFLWLARKLVGNPTLEFAAAPALAPPEVQVDEQLMAQYNAELQAAAAAPLPDEDDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNX4</accession>
    <name>W3VNX4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNX4"/>
    <dbReference type="HOGENOM" id="CLU_038321_2_0_1"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="283" mass="31417" checksum="18C1375FCE2A542C" modified="2014-03-19" version="1">MSFFNSLGRSMGRSSRPKKSPTHPNMPTFDPSSLSNPGYPRSPTSPSSASALALGGSTKPLYLCQPFVGASLVKGSLKTISSVPKYVDPKEWVAVNLFDFFNNLNQFYGVLTEFCTVANNPTMSAGVGLDYTWIDQNRKQVKLPAPQYIDYVMTWVGGLLSDEATFPTKASRDFPPTFLTTCKHIYKQLLRVFAHIYHAQFHHLVHLCCEGHFNSLFAHFIAFGSENRLFDYRDFKWSGASPPPSSTAHPQHSPPAAGYPGVCDLIERWVDMAILGPECIGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPM4</accession>
    <name>W3VPM4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Propionate- ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPM4"/>
    <dbReference type="HOGENOM" id="CLU_000022_3_1_1"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="765"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1127" mass="120507" checksum="9A07007500D6BE95" modified="2014-03-19" version="1">MAQTHPQILIHRQSIHHKDDFWLRAARAIHWHKPPTVAHGVSSNRNAPYLDPQGATWFPDAQLNTCFNCVDRHVYTQAHASAAPVTASPDTPHLALAPTAHRVAFHHVSPLSFQTQNARSITYYELLQQVQIVAGILRHKGVQKGDAVVIYMPMVPETSIAMLACARIGAVHSVVFGGFAPKELAKRIQDSKCKMVIAASCGLEPKGPVDYKPLVDEALRVSEHKPQSGLLFLRRHTIKGHTPATCASEGRPGPAGLPEWDWETETRLTADRQGGRSPCWECVPVASEDPIYTIYTSGTTGAPKGVCRLSGGHIVALRYSIEHTFGMTPSDVMFCASDLGWVVGHSYIHYGPLLLGATSIVFEGKPVLPDAGIWWRICSQYRVTQMFCAPTALRAIVGQDADAQLMRAPGVDLRSLRTLFLAGERSEPQIVARFERLLKELAAPGAQTNDNFWSSESGSPITGLMLSSAFGPLPARPGSAGLPMPGMDVRIVDDNGRELPRGKMGNLVLATPLGPSFLGGLWRNPERFHKSYFATFADKGGWFETGDQGVIDPDGYVSILARSDDIINVSAHRLGTGLIEQVVTSHPDVIECAVVGAPDKLKGQSPFAIVVAHARVAAASGDQPHNSAQSDSAKQMLKNINDHVRKEMGPIAQLSGLIEAQKLPKTRSGKTLRRSLRQAVENAAAGKRNAPVDFPPTIEDKDVIDTVRKAIEQYFDALDSPNASATSTSTAPPADSTPAMSLPAGVKPTMKALQLERPAGEAKKGQRNVALVREVATPKPKSDQVLVKIHAAGFNRRDEWSMVGAYPGLVYGNATMGCDGAGTVVAPQGFSVPNQHPDGLVLLTPTRGWDSDKDGPEAELPGLSDEERSNGLGGKGFGILGATAPTNGVGTFAEYVAVEKDQIVAAPKHLTAEQAATLPCASVTAYRALFTKAQVSKGQNVLLTGVGGGVAMLALQMAVAAGANVYVTGGSADKIARAVKLGAKAGTEYKDTNWPGKIRKLLPRARPYLDCVVDSAGGEIAAQAQKAGLKAGGRVVIFGMTAAPKLTYTMKEVLKNIEVLGSTMGSAKEFEQSIRFVEQHRIVPVVDTVLDGLEQADQGFELLAQADKRSGGKVVIRLASEQPKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPX7</accession>
    <name>W3VPX7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zf-c3hc4 type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPX7"/>
    <dbReference type="HOGENOM" id="CLU_473357_0_0_1"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="111"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="601" mass="62108" checksum="9872910358731555" modified="2014-03-19" version="1">MGQQQTKEAGAASGHARSSSRGMSASASANLVASLSASSLSPPPPPPLPAHLADTVKVDEGGLVPHGVYTGPQDYDQHFVRQHIVERRLAPFCKGSDDDDEYADADFNSECPICFLYYPAPLNFSRCCHQPICTECFVQMKRADPTSTNPPSSEPRSCPFCVEPNFGVTYTPPEALQHEGRRSGSGSGSGSDSPNDATDATNFAEMAIGNGGVGSLGASKKRILAADDPSVITVDQVRPDWHYKLAQAEAAVARRANRRVIMRQVGDRLIPIGISSSRMGADLAAAAESGRINLNGPGGSIILNDGQNWPGTGSVTTSRRRSSRPSRGAGEGLPELARLMRMGAGEDMEEAMVMEAMRLSLLEHEEQQRKQAEEEKKKKAAAAGAASGDSQAEQGASSSSGPTVGSTASRLQTDAADRTSGGRATTSGGRATSVMDESEAAGSSAAGSRAAASSGAPRLPMSTVDPASLGLSETTINELRELIDGGPSPPASSGSPGEASTPAGGARPRTSMPAPAPVPVPQPVADVQHDPNISSQHGYPSPPPEAGGAGKHVPTAYSTTTAAFDADSSAPGSPSSSGFGVPRSRIVNPNNPFRRSMGEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ46</accession>
    <name>W3VQ46_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ46"/>
    <dbReference type="HOGENOM" id="CLU_1939049_0_0_1"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14264" checksum="72AD0913BEE209BA" modified="2014-03-19" version="1">MRDPTTCTVLYKILTPQEKDALPATNWAGTALDTKDGFIHLSSADQLAGTLERFFSPATGCGDTLYLYTFDRAIVDKPRETPIKLQFDPAIGTLFGHIYGSINPESDFSGPIEIKRSSSSGLFELPSLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ70</accession>
    <name>W3VQ70_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-galactosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ70"/>
    <dbReference type="HOGENOM" id="CLU_267652_0_0_1"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="904"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1094"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="909"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1221" mass="133184" checksum="CED2B6E97BFC8D77" modified="2014-03-19" version="1">MRFAPIFQPALDTFRSVSLDQACGDGLSFAAQYPMDEYAASLANGAARLELWTNLPVLQNSSESTSRPVAWNAYPLLPIKAALHRAMGYSFAARVQCLPAASEGTFNFTYRIVHLDGQIDWLGSPSTDGRIRLPSSDAFPPAIRQLVLPHRGTRLELSPFQEHDHSVELATLTHGGGASATSLSFDIDASEVQSGLVIERTKSTWCTSRRFRSLHEVSPDFAAGLLVLELSKAAAGEVLVLMPVFDDTVLPPRFVRSSSINNKANFQIEIASPRVQVKVALALGASTQLERTIKACRSHAARLLRTCGHEPLGLPWSAAKALDVEAPLAAGIDVVSADTKIYSEPECIDISFYSDSTAVEGTITTQGMEDSQLLSTDDTQSISDSDDASTIHEDRTVHADSPPSSGQPKAGLGFCTWEAMHSHERRPYLSEVVAALEAAEKRTGPGSITSLLIDDGWQDVLHTQDHRGRLSSFDMNPTMLDVVDAAHPHDGSQSVLVSYVGYIRNRFPSIRSVGCWMTLAGYWDGINPNGSIASSLSSPLRSMRIHDPYRHADREWWLPATELDMHLFWDKAFHSLRSSGVDFVKIDAQAEWEWTQAPTEPLTKGSNDMMPGGGELGKAMFEAMEGAAARYFGSGGVIHSMAFTPALANTARTLHSQGMTIRCTDDFFPNIPDAHRHHLAHNVYNALLLPEHVCDADMLAHCHTEADSRQDFTGYHASFRAFTDAKLWLSDRADAPTSTSMRALAGPAKLSCQSERVRVQEKGRVLSNAAFEDLIGDGAGPALKLGVWHEATRSATLGLWNLRGASASTFDVLDIAQLLQMHDQLVAVRSFRSGKTWLLPGRYLEENSGLLSAALETGSWEVLTVAPVQMVPSTSVGVAMLGSNKHFMTPEGVSLVTISASSSMDEGLKKRRSSFSRRPSHQRRHSTRSVSTSGDSASETSLVAQSATDRLVQDVPSDSRAVLLSLALINGFFALMQGAVTGATGSPRAVTGRPRPKSKRGRVDVVDTMLGLIDQLQTLVVFGVLILASWTFILPTERTAGAAKSWLPWRNSQDGDQRVDDNALKRVRLSPHDAVTTLKRCLTSRTMAPLREMPVAITEPRPTSPSPRSPSSRRYSRQSSSDVIFSCLVDAATIIDFLVLCEGQDKIKECTIDRIKYDCTATPWISISPIDLEEGSEPWGDKHSAWRVEVDMQAWLEHQDVTYVQTVAAPVRVALRIAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ79</accession>
    <name>W3VQ79_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_01934</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ79"/>
    <dbReference type="HOGENOM" id="CLU_000995_3_2_1"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="467"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="787"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="830"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS63635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="977" mass="108006" checksum="B5F5EE7BCE131CC9" modified="2014-03-19" version="1">MSSSSAMPSSPLGRVGGATRSTDQNRLDPLAFGRTNTTGAGSNAQRAFTPGTSEAGSLNLERQLRGQYEDDASTVNGELSRPMDEDSTPRRPRPRAAVDTQDIPPVVDEVGERVREGFAQFLESFVDQPLSGSPDPNGEKVQDPLYIDQIYALRDYNRTTLFVDFSHILRHDEVLARAVSDQYYRFVPYLRRALLDLVNTYVPNYLYLNAHVAATAATGLIPRDFSVSFYNLGLVSGIRDLRTDRVGKLVSISGTVTRTSEVRPELLYGAFTCNTCQTTVRDVEQQFKYTEPIMCRNPVCQNRREWQLNVDQSRFCDWQKVRIQENANEIPTGSMPRSLDVILRSEVVERAKAGDKCIFTGTFIVVPDVSQLGVPGVNAQIQREAQGGRPAEGVNAQGVSGLKSLGVRDLTYKTAFLACMVQSADARGGNDIRADFTDDNEDPETLMDSLTEAERDELEAMVMSEDIYSRLVQSIAPTVYGHDIVKKGILLQLMGGVHKQTREGMRLRGDINICIVGDPSTSKSQFLKYVCGFMPRAVYTSGKASSAAGLTAAVVKDEETGEFTIEAGALMLADNGICAIDEFDKMDVADQVAIHETMEQQTISIAKAGIQATLNARTSILAAANPVGGRYNRKQTLRANVAMSAPIMSRFDLFFVVLDECNEAVDMNIAQHIVNVHRFRDAAIDPEFSTEAIQRYIRYARTFQPKLTPEASDLLVDKYRQLRQDDSGPGKNSYRITVRQLESMIRLCEAIARANCRHEITPAFVREAYSLLRQSIIHVEKDDIDFDDEEEQQQQQNSPLKRAATTQPSSSLGAMDEDSMDPNGASMRQASSAAATGGATGEMAASSGASRRKIRITFDRYMEITSLVVLRVNEVERQTMRGVLKSELVDWYLLQRENEMETVEQFEEETELIKKVLSRLVKDSYLLEIRESIDDEGNPITGTDVTASGVQGSAADPVLMVHPQVDIDSIGATTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQY3</accession>
    <name>W3VQY3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQY3"/>
    <dbReference type="HOGENOM" id="CLU_332644_0_0_1"/>
    <dbReference type="OrthoDB" id="2434934at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="924" mass="95963" checksum="AB75F30C54A03C4C" modified="2014-03-19" version="1">MTASATTAQAAAASIDNAVSPGVTSSEAVDLAPAAAQPAGRGKNRFSLDALRLPFLASPRKVSTASVAAVDGTAISEAPESDVASSSDHSASKGARPPTPPQAHGSVPNVTTQQLAPLTEVLPKRSALTSSVDASARRASRTASPHRVSFSPSTEETALAREEALAFAALASESSAKPSPPHHESHPLRAAKSKRKKANLAKWRGFKSKSTSDLHDPTHRPSLDSVHTGTSDATSSSSHEAFEDRAALPGAAAAKRRLFRWDRKGIHRVAADGSRDKGKAAKVKVTKHQALAARHAKTLEQVINAGMGLHPVPARVSSARHATEANYADANAKGGKKKHVPRAKPIPVVDRSQLRGLKSALLDVDLANNIISELRSMPVPLDALRSGLGRMMPETEIGTAGEHGQERILVTNLPDTALEGPKSKDDSEIRKRAEAVAGELDTVSAAKSTAERPPMQHKARSAAEEALRKITLQADAATTPRQAVPTARTSSLPPPAEESNTAAVAISPASVPGPSATTPPAAKQGGAKPGARPLKMVCLDCGEHEAHRRHADHLEAAKVVTSEGSSDVQTVTGLSVTAVASGAAAALMGVGGLLSARSQPAEPEKAKADGSSTSARPPMIKSLSVSNLPTLGDGQRLMGSAPLQLILDPVGTVAQNSGAFDVLANVSGAAIRATQDMDAIHPPLDRMAIFVHWWGFEITLPKASMAYLGTAHSVSGAFLSFLQTMAVGGGVPELLPFIKYISTFMEVEYKAIQAQDQGHGVCIAGTWFMPLALVPRPWDYPLDGPAPVTPTPAPGAAPPPFLTREAAAQPESAPKRHAFKKRPSLEAADTASVQVAVLGNGAPPQHPVPPTRNLSPSQLAAIHAARTEKMAHDLSPHHSRSSSIASAKSAKLLADLGSANPTLAEAALASVQEMPEVGSLRITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR35</accession>
    <name>W3VR35_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NOP7</name>
        <name evidence="3" type="ORF">PaG_02269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR35"/>
    <dbReference type="HOGENOM" id="CLU_019619_1_1_1"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000073">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="671" mass="73564" checksum="8F55DA06503FB09D" modified="2014-03-19" version="1">MAKIKQKGKSGAAKNYVTRNQAIKKLQVTLADFRRLCILKGIFPRQPKSVRKANKGSSAPTTFFFAKDIAYLQHEPVLQSLREHKTFAKKLSRAIGRREWAAAKNLDESKPTYRLDHIIKERYPTFRDSLKDIDDALSLLTLFANLPATDKVSAEVIATCSRLCAEWQLYVMKTKALKKVFLSIKGIYFQAEVNGETITWLVPYLFTQHIPSDIDFRIMYTFLELYQTLLGFVLFKLYTDENLVYPPRFDATKDEQAAGFGALSLDPASAAVLRGENAAAVAPSTSSTVITASGKKVSARDVKKQIKAIAKSGAVADDVDEADEVEEEQQDAAEQDTFVEQPSKSAEEQESSAHLTTFDEIQAASAASEGAANGLFTPYVFYISRECPRAVIEFVLRSFGALPGRIGWDMVAGAGSTVDEDDARITHHIIDRPVPAGGMKKYAGKRVFVQPQYIVDCANARKLLPAGAYGPGQTLPPHLSPFVDDAEVARRGGYVPEEAREQLGLEADAAAAPSDDDDDEEDEDVDEEIADEDEDEDADEEPTSKAEESSRPALAALLADPADATDAGLLDAAELEAEAAGGEDALEEMRRKHAAALKEAKKKAKGSSAGGAAARKSDEQEAKEMTKMMMSNRQRKLYEKLNYSSGKRAEETAKLQQKKKALNKKAAKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR57</accession>
    <name>W3VR57_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuole protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01379</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_0_0_1"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="819"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="921"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1047"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="1118"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="1366"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1479" mass="161500" checksum="1C978B1DA30AA037" modified="2014-03-19" version="1">MRASSRQQRMHNVHTRGVRGILPIRSGRATLRASAGATRGCPASNRLGRRNHSKSKSAPQTHRSTTLSHERTLLIGPTKPPRTVPPAPPQHAITKALAPPNITPFPSHASIEFQHQVFGAPGSLDPPVSVDRHHRLPASVVTFCQDKSAASQPQTGSLAIMSSGAGGGPEAVDEASSLLPANHSSQPRRESFSIGRLINPFRGSAGSAGSAGAQRATDPQQYQYDARRPSNAWTPTSPNAPQNAQRRRNNNNNNKFPRSVTFDSPHSSFPPGPKQDRSRVTSYHPPSNNRSHGMDDDNDSGYDIERQGSGWNRRSVNSSAFSHLEGRSYRFQPSQDTASLATSLVPGSYTATSSSIRDETAQLAGMIMSDDEAQGSTSDSHMSHIYDIGEGDEEPSPPAQLFPPRAKDAADFSPTTSPIASLGVQAGPSNLTRAMAASHQTSPQSAKSSLRSEDDGSQATPRVTSFLGLSQPVATPQNLAEEDELEDKSLGAGLAAASPANESRPLSRSRSRSSARRTSRSHPASADRSVSRDRQESETGQSSFSQFSTSEQQQRAGIGYGALAQAEQSVFEAEHGIPRQPRRASHHPPEPQKTLNPFWTMVPKGWRPGEGEYPIRSLNPAQHVHDFIQSVRGITWKSAAEASVEPIRLIPAVILGMLMNVLDGVSYGMIMFPAAYPIFANFGGDGVSMFFVTCILSQLVYTLGGSIFKGGNGSMMIEVVPFFHILVRIIIEELGDENPQAVIATTMVAFALSSVLTGLAFLLLGALRLGVLIGFFPRHILVGCIGGVGIFLIETGLEVCSRLQSEDGFQYNLDTLRYFFQSGHMVALWLPPLLLAVLLRVITSRFHHPLIFPGYFLMIPVVFYVVASGFLGIPIQHLRDDGWVFDIGESASKAAFYRFYTYFDFGQTSWRALWATMPTQLAMVFFGILHVPLNVPALGVSINEDNVETDRELVAHGISNMLAGLIGVVPNYLCYVNSVLFYRVGGGSRLSGLMLAGGTAIIMIAGPGTISYLPIMIVGALIFVLGIDLAKEALYDTVGRVNGWEYLTIWVIVIVMTYWDFVIGILAGIIIACCFFVVQTSRRKTVRAILDGSVARSTVRRHMTQRHFLDEVGTQTQIIKLQGFLFFGTINSVENLIRRALDIAAWNQNPIRFLIVDYTLVSGVDFSAAEAFLRINRLLMAKGVLLVFCGLNPDSDVGVALRSVDLWADRSENLEVFANLNEALEWTENEYLRGMYASSLMAAKAFGKASLAAEGGLTVPDQKRKPAFVLDHSVENSPRRHHLHEAAKTAVRSERTTPISEIVPTLPTEAKEGDSAIPAVKAAAGQPLPLLGITFRAYLQGPTGVAEEEFFTQLVPYFVQVRKGKGEVLWSRGDVADGMYLIEKGIVKARYDFPQEQYEINEAMLAGTIAGELTFLSRKERNTTAYADTDCTLWMIDQDKLEAMHSERPQVYQRFVEVLLRVAGDEQESIMSYLVSRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR61</accession>
    <name>W3VR61_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR61"/>
    <dbReference type="HOGENOM" id="CLU_035914_1_2_1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833502" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="329" mass="36578" checksum="17FC5AB9C1D21D03" modified="2014-03-19" version="1">MPAVPWFSALLLVLVARQAASLPLEAQQHSPLHGRDSVKCSSLKQRVNWNSLSAAQKQSYFDAVKCLKTKPSQTAISASQSLYDDFPSIHIQQNHNIHSVAAFLPWHRRFVQAREKALQSCGYTGPTPYWDWTKAADTGNPKIDPIFSPDDGFGGSGDPESPNTVTQGPFSNFALDIMPGDDDEPYSDPHMLRRNFENNPYLIGNFNSTAVQKGQAIAAFNDYRYYVEGIPHGAVHQYIAGDMGPASSPNEPLFFLHHAQIDRLWALWQDEDVKRLNDYAGNLPGASTRDGPFQATIDDMLPSFGNLIDQVSVRNVMDTRAGDLCYEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRH5</accession>
    <name>W3VRH5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRH5"/>
    <dbReference type="HOGENOM" id="CLU_016852_1_1_1"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="311" mass="33584" checksum="4D9F901964B9BC07" modified="2014-03-19" version="1">MSSSTVTPKTLTYVSGSSDSEQQLDLYLPSEQAASGLVVFIHGGAWRTGSRKDHADLASHLCAKGMAVAVVDYRLSVKDDQGLPKHIHPVHVQDVNAALAFLHVRDDVPHKDWVVVGHSIGAWLTLAAIISGSSCSPDAQYPAPMPIPNSAARDSIKTCVLVDGIFSVSALLKEYPDYDGFVAQAFLPQPSPAKYDAVSCENWPLALDGKQLHVWHSRDDELLSFKQSLDIILHLDSKLSTAASASIPVVIPQDGNASTTEVQGEKKLLASLYADTSIKNANHLHADLTTLRGAHDDLLHTETFWNLILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRR2</accession>
    <name>W3VRR2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-4 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRR2"/>
    <dbReference type="HOGENOM" id="CLU_014184_1_1_1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="352"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="447"/>
            <end position="450"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="60512" checksum="6563752C3FFD8259" modified="2014-03-19" version="1">MSPTVSSRDIRRMQSGNMTPNDRDPLSLALRPPSNETAAQRQVRLHQEKQAKLRSEEIDKLLKHTEASTSNSASLEAKKGRVYKMVLLGQAGAGKTTVLKQMRLLYDAEAHERERKGWTSIVVLNLTASVRVLLQTLERYHQGRAERKSLELARLESPASPVSPHSTHNTVSPSSATESAIETASARALGPSNTAWERHLPKVMQLESKLRGQLGAFGEEAPVNDPESRMMTTRRTKMGDKSLLLLRPGWQERLFTYARRSLSLGAGGRNSMQEQTRRGEEAGDDDESDALVLLRSIQAEVTALWDDDVRCRALRKRGVFLDGQSEAATSYFLEAYARIVAPGYSPSDEDILHSRVRTLGVTEDVFRIDRSLTYRIFDVGGSRSQRAAWVPFLDDAQSIIFLAPLSAFDQPLIEDPSTNRLADTFALFTQVVSHPLLRRASVILFLNKIDLLEKKLRQGRSLASFWPEYGGDNDFEAVWRWFRAKFRDELRRAEDDGVGARRRLYVHTTVATSTRQIKAILMSVNDSILRDNLQAAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS29</accession>
    <name>W3VS29_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS29"/>
    <dbReference type="HOGENOM" id="CLU_044621_0_0_1"/>
    <dbReference type="OrthoDB" id="2425131at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="482" mass="52616" checksum="462109D0EB25DDCC" modified="2014-03-19" version="1">MTARIRARALLRTASQAPAAVARTRLPTQSLLASPSPICKTAVRRYAVPSSFRVPDAAELESSVRRIFPSARYSDSSASTIDYDQACSLLTKLLIQLRTTADLPSAADREAYQASVDNDIISNAKAWGVGSGHLTELANVLLSASSDPRRQPLAFRLFEVAHQFGSDDAGYFWASMVLQNTAPPPPSGDAKARVQRALSLYQELSDAGNARGSVGVARLLLQRIQRGQVDKAQWPALIQQTVNLYTKAGDNGLAEAWYDLATLFQESRFNPPDPSRARAYLEKGAELGHSGCLFALGMQHLLDEEAGDKAQAFDLFKRAAEQGDAQSMFQVGSFYFLDRDKLAQHPDVTGGDKTMKQAHKDSFGVDPDDVEARFWLEQSAQSDYPPSILQLATLLGQHRALDPGAHQKRGLRTIDKTQADQLSYALLAKLLAILKTSGNLPSLPSQKGQWSNSQFHALIPHAQAMYEKLEKKLGDAPNDSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS75</accession>
    <name>W3VS75_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS75"/>
    <dbReference type="HOGENOM" id="CLU_029564_0_1_1"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="379" mass="42598" checksum="B778E062D35F53C0" modified="2014-03-19" version="1">MGLPSKSSGSSRQRSYAYPPPAKGISRCWAWIPDSWACRLFLLITLAEASINIAIESMLFVRYQFHRKTHPTPDDDSKSRALPVFVIVFSIAHIYQFFLAIDAVINRNTILVIGSIIFNACFLVYSLIQISEIRTVLGDGVALGSSQTVPVQVLTGAIPIVIALAEISFVVLGWKLWKEFGWQIYKKIGADRSLKRGYLHYQVYVALLKFDFFIFIAYCIQLVLVVKQIGSAERWITIISAPFSLLILFFAWYSVRKELKYGMLAFLVGLTGAMVYFVYKLFRIWQLKDTLYKEVYKSLTVFSTLSMLLLLITAAMTIQCMINFDRGLKHAIARTRKDHAAAGAGADSGYLVGYDGKTLTHLGDGSTSVLHLQPRLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSD2</accession>
    <name>W3VSD2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSD2"/>
    <dbReference type="HOGENOM" id="CLU_292038_0_0_1"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035060">
        <property type="term" value="C:brahma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021906">
        <property type="entry name" value="BAF250/Osa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656">
        <property type="entry name" value="BRG-1 ASSOCIATED FACTOR 250 BAF250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656:SF5">
        <property type="entry name" value="TRITHORAX GROUP PROTEIN OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="2">
        <location>
            <begin position="605"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1043" mass="112542" checksum="73313D5EF06815C6" modified="2014-03-19" version="1">MSYPQHPSPAGGAFAAASPSVIRSQPLPSVPSQPQMIPGMGMQQPHFPPQQQHQPMPGHPNLHRPIASLPSHARHMQPPQTPSARPIMPGGRLPQHLGGARMTHPSADPSASFKRPKLVGDGYEASYLVPGPSNRILLSLKSGLPVQIDWALSRLVHVTANNRDPAAREFTLDSVPGLADALISYVRRTHAALTDQPASQWAASYFEQPADTIDVGVGAPGDTGHSGTTSSSLSLTLARNASSSHIQAGPFNPAIHADHAILMRRTLEAALALRNFATHSANIRSLAAVKGIFALIRDVLSLPITAVRNGVSHTSSHDTGSSSHEDGWLEMDGIAELRLYFLDILESLASRVVLTRRAPNASSNPPSANGTLSHSAEARPPTSANSPGDDIFALLLSFALHSKDRAFLLGSLRCLGTMAANERNEAAFVESTQPDAQQSPGLLQRCVELLPVTQDVELLEPLLDLLYQLVCIGNNAIKIASALSLDSRRPRSPSSGQLTASNGRTGASRSDPRLGTRATARTAALVRFLSRNLQLGRTMWERVMPLRVPQDWIVSIPNRQLEAMRRSREVQMRLARETPEERAQRKKLTRRERREIAGLKEPERGIAWMQMVFQRNPEREVTQMEFWTAYKEEFQVNNDGVPLQAAAELIRAVSTVFPQAAAMVIPAQEKQPQRFVIRGIDVKERQRDQLEPCRCCWSTCPAPETNTLEAQKKHAKLHVEHAADGRCRWKNCSFDVKNSPGAGAVVEVQQVLMAHVLTHLKTDGSAAAKKARKLGIVVDDDLKVVSGATHTGEAAPIVTGKGVNGARALRARRKSDGGEISFTLDKADPAQASGNVREAKVSLSAARSDGTVDNPGMYVFDVTRTPTTGNDDALSPMGPAFTSVLILRMLTRRAASLVQKAGTKEDGEGEEQADAAAMRGFGDEKFGLPLPANFGASERGKQSEAGEKGDVADEGADGSALGGDEEDYETTASWAVESANRVLDAVESVEEELMHHASENDILSSYINETLMELRRRPTNSVASSKASTSASLVGRVDPSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSF8</accession>
    <name>W3VSF8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSF8"/>
    <dbReference type="HOGENOM" id="CLU_100274_0_0_1"/>
    <dbReference type="OrthoDB" id="10323148at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834545" evidence="1">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="154" mass="16776" checksum="49D51B2CB5D9DCE6" modified="2014-03-19" version="1">MFFKTLCIFFVAPLISSVVAGNAMGRFATDDNQVGRYCNRNNPPQGRFVCFQYNGNIRDGMTSTDASMHGYVNSAGTSKSKSLNTVALWVVCADRRASVGFVVMFDGPTEAFSTGRMDVVISNSNPCLEVSTLDSGGDSREYQGCSYSPPIWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSH7</accession>
    <name>W3VSH7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSH7"/>
    <dbReference type="HOGENOM" id="CLU_1950415_0_0_1"/>
    <dbReference type="OrthoDB" id="2542050at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833246" evidence="1">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="134" mass="15225" checksum="56DF9D7709EA3934" modified="2014-03-19" version="1">MKFTTALAALSAIVGSAMLAEAAPYQVKAVSWSEIQHKHAHHWKFFTQPRGVDLQELQEAKPFYGHCNTPKAFISNRKAILHTFLNNPDFEFVQVDDNTIYANCINCSPQIMSNYYLTKLSSYIDCHVLDSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSK6</accession>
    <name>W3VSK6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSK6"/>
    <dbReference type="HOGENOM" id="CLU_008524_0_0_1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="7">
        <location>
            <begin position="279"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="504"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="547"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="589"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="631"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="673"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="715"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="849" mass="90681" checksum="729A54DD1735CB6D" modified="2014-03-19" version="1">MPPPDDAAADADQNGTGRAATAMPPNPPTQITITAAHDSSSSLPSSYPSSEPALPSPAPLTPRASTFRLPEPGSLNGSHYQATPTGSFTAPTSPTAASAMFRTNTIGATVDPAIAAGHLALDRSVSAQPNLGGGDGLGISALLSAAASGAAANGAAAATANDSTAAASASGGTKETWKRRKQVLLADAKDHTVADLQLHGLRPPPYGYHPHYQNSSILGQTVGQLTAHTASTSTSTSASRDTNHATYASSRTAILRPDDPHLLMEEAGIKRREREEAGLDARKLRGHILEGDWPEVDKLLQKPLVKNHKAFLYAVYKQQFLEHIEHREFQKGFTFLNKRLKPLEHYQPHPSEFRDLCYLLSAKAVTDAPSFAAWEGIQPAREKLVMEFAAMLEQDWLEKEAGLPGSGSASGGVSAANAARAGSETSDLLDDAMLADGSAAPSGSKASTSGYTYVPPHRLLTMLHQAVAYQVEFARYHPKKAPVISGLLHDYTGFIVPNAVAHTMRGHRKNVKSVRFVGEEGRKIVSGSSDNTVRLWHANTGRCEGVLQGHRSRVWDVDSTRTGGHVASASGDSTVKVWDVESGQCRTTLRAGVGDVYSCRFHPDERHIVSAGYDKLVRMYDVETGSIVKTFTGHQLGVSSAIFNPLGNLIVTASKDTTIRFWDVVSGLCIRTITGHLGEVTSVEINETGSLLLSSSKDNSNRLWDLRMLRPLKRFKGHQNTSKNFIRSSFAHTSLLVGGSEDGLIYMWDQESSEVLQTLEGHGRDTLHAPARAGLGGHTASGTATATSVVSDLTSLSTNNNVAYGAVWNKAQSLLASCGDDGTVKTWIWDEGRDLEANADLARRANDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSK8</accession>
    <name>W3VSK8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA polymerase II-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_246805_0_0_1"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="457"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="1354"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1148"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1541" mass="168200" checksum="4F109C5DB7A0F3D2" modified="2014-03-19" version="1">MASQDERELRKQQIRPRFLDLAEFDDDDMAAHPSSRRAAPDSFSNWPPAATVVRRKPPTIGSSSKSESKGTKVEADTARKATVEDVEDDQRQRSATSHQGETTQKTPTTEQLRSQPDTKSVRFAPEPTAQAPEEAAQRAPPKVTLDLTGSIIGTIQERPVGERRTKASASTKSKPAVSRFVVRKRMDEELQKHEEQRKRQSHSAKQPEDQAPGTGFPVVSHRDHITPILPPASGSARANFNEDIASVEAPRQDDIATRSALSTSSAADNAASADDEEWLDEAGNPMSAFRKSRLLRQGLQPPSVRSKRAPAEPDSRDNTFRPDPTRDPGGGADIDAITAVLTDVSRENENKLRNMSASEVSDELRSLESMFGKDVLDALRNRKSNSAAKPVDKLAASGSMKPSQGASRTSSIPVGETDAEGPLAIKRQYFPAEPEGPNPSIEWMMPQPSKTKQGPSDLRYDFSGKLISSDIESDKTYLSGLHHHGDDQDAPGYTFAELIHLTQSTVAAQRQLAVNVLGRISEHHPAVGQAASAEAAVVTEYLNADSLLLRARIISISRFLLGDRHFTVRAAALRSLISAIRSLPSGISVPLGCEQELEFKSLFAPAAKLGLNQEDTPAEASEVEVKIQGDWAHVMLESKLVSLFLDRTDSVVTSRWEAEVALELLYRIASCSASHASKVFGSDPKRMCDWITHLGLNVGWPPVPADDQNPASGSRSQNALPSVFAVRLLHQGILADRKTAEAIALSGSIEHLLRFVVTPPWKFEADWTPNDGGDDATILVAYQVFDEVLQLFASLASYGFFASVVARTWQLWRECGSWAMEHLVNGQVGSVPAWCEEARDTAAQRIFEVLGAWTRCAMDPHELMTAHDITWTQVRDWIDVVHDASQQLDRTLANSRTTASKAPVLGALCQYVDHWLRCATPKEPKIVERCFHSCNKVLRFSQIPIQKQVVSVLRLFESALSQAVALDEAEQACQAFRRYADLSITCKEASRSAAKGETTPEAIASDASVSMVQEGLTLVSCQPLWQALESTESQADGRHTYKQAFSEFVAATLISDSSSKTSMSSELAAIIRLDEDHVQAVWQIVQRAATHYGGSAALDALRPFLLECIMGRNCVPEPLAGKEQGRSHTPLSHVSSLFKARRYAADQGSAEADERKEADDEQAGDDDDVDPITGGQLWSCPAAGLPLRADWPLLALDDLLHSGTTAVFNRPDNLDADWKPSELEMVRACLQLAVAMLQSQLRAHAPSAFATEELSVEAMASLSSLPSAEQVLLGVMKVFLLEKDQPDTFTDRSAAGQNQEKQAGALTGRDLFRDSEVSKSLGALLDVADQLVELRAQLRGKVSMSTVTLDAWTARTYGGAMSSYQVFTDLLGLWDSVSFGDANFARVVMTIANAGSGIEGEHGIAVDFRRLVWNDYSDSLRSIPATPVAAWLLSWTETDVDMLENYCRYLATVAEMPAASSSMAWQIASHHVAAALRTLTDAPQESVEQRRAQAILKTLIAAKGKKMLDELLATSTNPESARPAEESQRIFSQLFPDASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSL4</accession>
    <name>W3VSL4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tripeptidyl-peptidase 2</fullName>
            <ecNumber evidence="3">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003084_1_0_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000003">
        <property type="entry name" value="Tripeptidyl peptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046939">
        <property type="entry name" value="TPPII_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048384">
        <property type="entry name" value="TPPII_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048383">
        <property type="entry name" value="TPPII_Ig-like-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022229">
        <property type="entry name" value="TPPII_Ig-like-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046940">
        <property type="entry name" value="TPPII_Ig-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF14">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12580">
        <property type="entry name" value="TPPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21316">
        <property type="entry name" value="TPPII_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21223">
        <property type="entry name" value="TPPII_Ig-like-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="107"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II first Ig-like" evidence="13">
        <location>
            <begin position="648"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl-peptidase II galactose-binding" evidence="14">
        <location>
            <begin position="771"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Tripeptidyl peptidase II second Ig-like" evidence="12">
        <location>
            <begin position="903"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1366" mass="149378" checksum="FE63B3F4C3ECEB36" modified="2014-03-19" version="1">MFRLPRSLGLPRLLRDQARIASPNRSSIATVAARSFYPHPSHSSTPARRSFATTPSFARASTASDATVSAMPSSQAIPSEPFPLAGLLPKDTTEAINFLRKYPQYDGRNVRVAVLDTGVDPAAIGLNHKGKVVDVIDCTGAGDIPLQPIQPISPSAGAHIDFKSPFTGRTIRVSSKLTNPKGEWKIGFKRAYDLWPGELKNRRSAERQKAFLVSHQALLCQAQADLNALESPAASKSPASADASPSSSDKTSPAENVKLQKDELKARIQTLKDLAASYSDDGPLIEVIVFHNGKNWYAVVGGGEGQTHDPARGQPEDLLKPLDSQTLDLSAVEPITDFRIDHQWQSFGQQDLLTYTVNIEDNGNLLSLVTLAGSHGTHVAGIVGARHDEQPDLNGVAPGCEIVSLKIGDARLGSMEQGQAMLRSAQALIDTRCDIANLSYGEDGAFGAEDKGAFAKALRDLVIRQRDILFVSSAGNNGPALTTVGQPGGTTSSVLSVGAYVNAGAMQKAEYALVEKGVPDSVTTWCSRGPTSDGDRGVSIYAPGAAITSIPRYCLQSSQLMNGTSMSSPNACGAIALLLSGLKAENIPITPARVFNAVRVTGKDVNDPLGVPFIRVDAAWDYLVQNKDRVEQDAEYRVAVTRAGKPLGRMDKRGIYLREKDETYNVQQTNITVRPTFKQGETEKAFNLELRCALAATQPWVQVPEFLLLGGNGRTFEVRVDPTNLPPGLHHAWIEAYDAETPGHKLFDVPVTVAKPELFPSPTVKFETVRFEAGKIERRFVHVPEGATWASLTVRSSNHSSPGTSARFWLHCVQLEPLQRLSEVEKAFVLVLQENEPVNKKFNVRGGMTMEVCSAQFWSNKSAFDLDLDIEFHGVTAALVPASGRQELTLIGGQGHAKIECQSTVRIEDFKPSVTFDTRRTFHRPTSSKIRPLTTPRDLQPSGKHMFELVTTYNISAKEDSNKLSYSFPALGNHLYDSSVPLLTQLFDLRKKRVHFGDVYKKEITLPKGDYALKAQILNENMKVLESLKNVTLMIDQKLSKPESAALKLYDNHVDLHSEAAPAKYNGIKLHPGERIVLTLDLNLEGEAVPKEAQPGDVLVGSFGFAAEGKGQLRYIVPPSVKSDESDDAAPGGKNENEIPELLTATAKKIKDPKEKLEFMDKLITDYPKFLGALVAKLEALDADDKDATKRQQVITAADQVLAQIDETQVKLCMATQKPSASEQTDEEKKANKAMEEKKKALVLALNRKARVLMTEAEESAAAHDELEKVWKQYREYFAPDSKAKEYVELYVRWCILHNRPALALQAAQKLKKELGAGTPDSIKEVEKMKALELRLVGKDGLNWPLWAAHLERAEKIAAPADYAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSL7</accession>
    <name>W3VSL7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RuvB-like helicase</fullName>
            <ecNumber evidence="17">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_00975</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="17"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSL7"/>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 17" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="65"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS64510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="499" mass="55067" checksum="219BA4664B842EB4" modified="2014-03-19" version="1">MAQISTTSEQTIQTLERIGAHSHVKGLGLDDQLEPRPSSQGMVGQRAARKAAGLIVKMVQDGRIAGRAILMAGPPSTGKTAIAMGMAQTLGSDVPFTMLSASEVFSLEMSKTEALMQAFRRSIGVRIREEAEVVEGEVVEIQIDRSLTGATKTGKLTIKTTDMETIYELGNKMIDSLQKEKITAGDVIAIDKASGRITKLGRSFTRARDYDAMGSDTKFVQCPEGELQRRKDVVHTVSLHEIDVINSRTQGFLALFSGDTGEIKPELRDQINTKVGEWREEGKAEIVPGVLFIDEINTKVGEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRALESELAPLVIMASNRGICRIRGTRFRSPHGMPIDLLDRVLIISTKPYELDDLKQILTIRAAEEEVSLKPEALEVLTRMASETSLRYAINLITTANLAAKRRKADAVEVVDVRRVYNLFVDEKRSVQYLKEHAEQFMSESDEYGDIDGLSSAAPIIGRQMAAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VST7</accession>
    <name>W3VST7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VST7"/>
    <dbReference type="HOGENOM" id="CLU_026945_0_2_1"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="141"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="448" mass="49432" checksum="21FAFB25B9FEEA8F" modified="2014-03-19" version="1">MALHPAPPAQGGSDDPRVFLDRLSGNWRYEDDEGDEWEWQPFVQLARPAVDQGEVEDDAPSTDTAPAASTSTQPTGHWVKVLDDDLVRAQQAAYSVDGVDESQPAQPVLRRTKKRAASPSDPNSSSSTSALPPSKRPKPITSLYVSGLPLDATSDEIARVFSRYGVLLEDDQGKPRIKMYHDDKTGMFRGEALVVYFKPESVELAINMLDETNMRAAIGQTSSSGPIMRVQRAQFPTESASGTKSEPPANASTKSTSNGPSGSDREEAGKGAQSAGQRRNLSEQDRKKIAKRVARLENKLSDWRDDSDESDDAHPSTTSTSNTNATSDAGRTVVLTKMFTLFELEQDPTLLLDLKDDVREECTDKIGGVTNVVLWDLEPEGIMTVRFSSHDQAQKCVQMMDGRFFAQRRINAFILNAKPRFRKSTTHPDDDDDNLAKHNFAQWLEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSU9</accession>
    <name>W3VSU9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSU9"/>
    <dbReference type="HOGENOM" id="CLU_041179_0_0_1"/>
    <dbReference type="OrthoDB" id="2555888at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="509" mass="54085" checksum="574F74098430747E" modified="2014-03-19" version="1">MLSTHAPAEGSERARMTASVYALHPSALDGARVCAFWRRLESESAPWNKHRALSGAAITWKLKIRRFYTGITRRLSACQELSAVDPCAAFSRRASRIEAGMGRSSSQSSGSGLLACISPRTATLAIAILGIILHLNTYSWLGALSSTLPDVPQRASAPLPPPASAAFVPSPDRFANSAAKDVLSQLESYAHAPPAGEDATNKNVYLPEWIAEAKAYLKAQGLSYVPNQGPAAAPDAAANQSATSGKSAEAIAPPPGRPFEAADAAVNYRIMDEGAEDAERMQWDALRLVIGTLRWYILLSVMCCCAGVVGVLRSQLLLSRLFVLHSFLDFLLSTLSLFALALVCTYPSVRAHLCDEFGSGELQAWFSPSKTAKGSAAGSAGAQVVPGSAGVGSNGAGVGGGAGPDGIVDSSGWETLLDGVFASENCEESFRTTLVPLLLVFGLVFTAVRLQCFFLVQRFYATLLRTKVHHYGYATSSASLESGTSTPMSQLPPAEQPRERRWKDSKLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT79</accession>
    <name>W3VT79_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT79"/>
    <dbReference type="HOGENOM" id="CLU_2097858_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="116" mass="12340" checksum="36E40D75AB9EA9BC" modified="2014-03-19" version="1">MEEESRSTGSGTAGAASLDGMTRSNASAVRCWMRYIRSAPEQLEKTPEQASALVAVCPVPAESFFKSICGETSTVRDGKEPGGAEMQGGLGKLEDDRFFSPRKVPFYDTVVSGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT86</accession>
    <name>W3VT86_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT86"/>
    <dbReference type="HOGENOM" id="CLU_293750_0_0_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="927"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1034" mass="112037" checksum="C0B4FAB636AB6BC9" modified="2014-03-19" version="1">MTTQHHPSSFSPGGGQTDFGPVRTNNSKAEDRDKKGPIAAPVKSACTFCRSRKSRCDGSKPCSACVGRGRPDECLYTVSRRGGKPKPKVDPTTDLQNHLNKLFAITDMPYAFRRPGGLAGPPAGDLGLAQSMQSQQIQPHSDIFGVPNQYQPFDPSVLQPSAVQAGMPVQQQQHQLQLALAPAHPAVAAFSLNDPFAPIPGFNPGGFMRYQLPDAPSQSSVSGGGPAHLQPQPQSQRQPQHQPQQQPQQQHQQQHPQQRPTQDFAPHKPADFSPSAVPQQHAQSVSATQQGAQAGRRDPLSPHSLVLDASHHPSGPSPQSNASPSTWQHADEAMAAYHASSVAAASSSGQSSSSRNTSVDNAVDSAKMYPASYKSLNAAAAEAGSVRALLTDYYRYLYRFIPVLPPPKHIDVLIKYFSPDSAFIYALQCVLPLLRDEIQPIGALHKLSGQGINFGSEEKKAALRERTLAYERKATDGLDHLLEQADTDDTGEKMLEAVQTLCVLVVYEYGSGRAIKARLKADQALGLAMGQGLHKLSHTTSPNEAKSARSSFAYISNAHHPLTSLGVDPSDIFEMRKRCWWSVWSLVLWAAYNTGRIPTIRADDPRVKSEMPVASDPSVWTSDISSLQALLLVQDRVLALAQYGHTLDASDARYDPARREVSMSPSSSGTSPFSFGRLGVSRSGSVSSDEAPTVFHALPTRATRQEILDSMLEIDQFLQEQIRIHESTHTPDSPLPSEVPQTGDLAHVEKELEDSLRQAAAVQLYTSSLTLHIGQAFQGASLFERKLCFLNSIKDNKDGSGETAVCREPMPALSFDNVMHAAPFVGTNGNGSGTEVNDASSLMASPGPGVQTTSLTQQDLYARGPFLPRLSLQRCVHASRKLLDIAKRRHGQSVNPNPFNCCSFVLISFVLLMQALAVHGGFAGEGDESPQDDGMFGFQDGASSNGGNDQGHYANESLQRLLEQSNTDDDAMMDSLEASADPAKQAQLRDIWDRVREARDTLVDLGKHWEAVVPMADEVNMCLETSQLLLSNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTG3</accession>
    <name>W3VTG3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ArsA/GET3 Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTG3"/>
    <dbReference type="HOGENOM" id="CLU_040761_0_0_1"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="24"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="332" mass="36595" checksum="EB3E44CF8D35768F" modified="2014-03-19" version="1">MSTALVEDALAPTLQNILDQKTLKWLFVGGKGGVGKTTTSCSLAIQLSKVRESVLLISTDPAHNLSDAFGQKFGKEATKVNGFDNLSAMEIDPNSSIQEMIEQSDSSGGAMGQMMQDLAFAIPGVDEAMGFAEIMKHVKSMEYSVIVFDTAPTGHTLRFLSFPTVLEKALAKFSTLGRSLGPMLGQFQSMLGGGGGANQEDMFAKLESMREVISEVNTQFKDADKTTFVCVCIAEFLSLYETERLIQELTQYEIDTHAIVCNQLLYPSKGSNCQHCKVRKQMQDKYLNEMAELYADDFHIVKMPLLTEEVRGTEKLKSFSNMLIEPYTPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTI6</accession>
    <name>W3VTI6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTI6"/>
    <dbReference type="HOGENOM" id="CLU_007880_0_0_1"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="748"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="874"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="979"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="826"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="979"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1058" mass="115052" checksum="BE21A55BA0EB52CA" modified="2014-03-19" version="1">MGRKAEVQRMMLEKLMGPEAMGTPTANLHFTDPKVCRNFLCGTCPHDLFANTKVDLGACPKAHTPKYKDEYRKALAAGQRFPEFEREHEHNIMAFINDIDRKINTNKRRLEQTPEELARFANMNREIAEIETALAAVMAEVEALGEQGQIEESLAELAKADALKEEKAQKEEELHKAQENSGASGHQKLRVCDVCGAYLSILDSDRRLADHFGGKMHLGYLRLREMISEFDERRRHPNPPPMGMPAAPPATSSSNGHATLPRPSLSAAAGSSAHRNGASASDRERERDFERERERRDRERKESREQRTGSQADDAAKRGGEEGELGEEEGEMVEDGPSRAQPKDEDRKRSRSPSQRLDCRDTGEQERADGLPRPEKAPDSTWEAAPNFEKVGRAEFGACQPRSLTTIYRRRRRGDLAQPASRMSYFLPHLPTGWHVDQAILSEEDRVVIIRFGHDTDPVCMEMDETLYKISTAVQKFAVIYLVDTTQVPDFNKMYELYDACSVMFFYRNKHIMIDLGTGNNNKINWAITERQELIDIVEVVYRGASKGRGLVISPKEAALKFRCKNIGLVLIMYTLQARTSKLAPPSEWFDNCDATMVKVKLRVPLSSAPRETSSPLANPLRSAPDYSDDEDNDTSPRPGNNGHDDEGGDDDDDQVDEDDDEEDQEADELDEQDELEEEEGDNSRAPSASTPKRRSITIKSRSSRGGASSSASPSMDGSASPHSGSSKMVKRTSLARMAHVQAMTVEELDALPAAKRRKTAKARGAAGPGRGWRKGLTKGQKPVYELPPAEKTPATFGNTANARPSVPKAETPTPSSFVTKSKPSSTLAASAEANRAAASSSAPTARASAATGSAAATSIKIVAGPGGHTFTGDLSAKAGTAKNPGFRYPPLPSSRAGPPVQPLARIPTSFQSVIPLERNGRQPRRWIKGKREILSMGGRPWSIPVLYGGDDRGYEKKIDAGTGVTTAAGAVAGAAAGEKIASKAGTPAAAAKANSPTPTPVQTPTPHPTSVKPPGPTEGARTGSSPLPPPKHLGGLSAVQAETNWRGQSPAFLFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTV8</accession>
    <name>W3VTV8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTV8"/>
    <dbReference type="HOGENOM" id="CLU_008455_13_7_1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF185">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="257"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="734" mass="79898" checksum="1901B3FE37863620" modified="2014-03-19" version="1">MLHYDNEADGMISRARQGFDRSSQRHAQDRVAQRRIVEYRSTAEVPRTRRRQASRGDSTSAPPRDSTPSPTVGSNGRPAISTLFDLRTFALDCFPPFWVMAREAEPLELARRARSPRRVASPAVCTQERKKNFGSHWVFIAEPCPFDPLYTCLLRPLRTLRPHAKQRAWQIVSWTALVSQAMCLDGLFPSYACLDASSLASPHPRLVIVPPLTFSPTPAPSSPTAFSATAATFIMRTGQLNHPDPQHPYNLPTWRKLLMLATVSLTAFAANEMAAAHLTAFPEVAESFKVTIAATANTIGIGILGLGTGPLLWNAISESVGRRPAYLLAWTLYIPCTVWLARAGSFNSFAAARFCAGFAGSVSQTVPASLISETFMPEHRGAAIAAWTVLLIAGPVTAPVIGAGILTKTTDWRWVYYLTLILAGALWVCILLFVPETLYSPNRSAPTAAHDAPSRNDDLEKKDSHSIEHGTATPPLSGSAGALESGSHGRIGAAWYPWKEPARFVGEIVAPLKMAMYLPVILPSIVYAVIFMWSVGFTVVSPQVFPRPPWHFTNVQVGLAFLAAAVGALIGKFAGGFVSDSTVNFFVRRNSGSIDGPRVPEYRLWALLPQVPLLVIGLLLYGIGYQKKLDWPVEVIGGIGVYYVANSAAGGILQTYIIETYFTKAVHGIALFNFVKCCLAFSAPFFVPEWSFEGFTKAYVVQAVVTAAVTLAMLVVLIAFGARIRKAQKMVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTW5</accession>
    <name>W3VTW5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00453</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTW5"/>
    <dbReference type="HOGENOM" id="CLU_056971_0_1_1"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="59"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS65004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="290" mass="31797" checksum="67D597A4D9D51913" modified="2014-03-19" version="1">MATPTPSAARAAWLSSIDAVYTLFEDTAVSAQYPELARKVAGAVGLCEQVLREVGEAHCALSFNGGKDCTVLVHILAAVLRRLHASSGPRAMAALYITCPSPFAEVDRFIKFCVSPEFGYNLRIVAVDGGMKEGIRTYLNGGGSTAEEGGRDIRAIFVGTRRDDPHGPQLEARSWTDKDWPRVERIHPILDWTYGDVWEFLRCPHLATSEAQLPFGRQTLETQWGTTGAGARGVPYCVLYDHGYTSLGSTFNTRPNPQLQDGDKWLPAYMLQDASHERAGRINTAQPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTX0</accession>
    <name>W3VTX0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">gluconokinase</fullName>
            <ecNumber evidence="3">2.7.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gluconate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00459</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTX0"/>
    <dbReference type="HOGENOM" id="CLU_077168_2_0_1"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS65009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="237" mass="25792" checksum="3B7D2AF85F30C16A" modified="2014-03-19" version="1">MSSVPVLLIVMGTSGSGKSTVGSALAQSLHCPFVDGDDLHPASNVAKMSAGQPLNDTDREPWLRTIRETGRTLALTQTQPETAPVKKLAEVYETSQQTRTSTDEAVDPTAHVSDQPTTGAKVAVIACSALKLVYRRLLRGSIQALDDPAATAEEHVQYKDLRTVHVYLDLSRDLLEHRMAARKGHFMKLDMLYSQLDTLQKPTPQEPDVIIVDVQPDTTTDAIIAQAVAQLRSQAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTY3</accession>
    <name>W3VTY3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00408</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002136_0_0_1"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="9">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="542"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="691"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="838"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1428"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1607"/>
            <end position="1640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1685" mass="189886" checksum="937F4201F659F8F6" modified="2014-03-19" version="1">MADKPINFSEHVQLTNVGIAADSISFANVTLESENFVCVRESINGTNSVVIVNLNDVSDVMRRPITADSAIMNPVQKIIALKSARQLQIFNIEAKAKVKSHLMNDDVTFWKWINNTTLGLVTESAVFHWSIEGDSAPTKVFDRHVSLQGTQIINYRASQDEKWLVLVGISGNTSGAPNAFRVKGSMQLYSRERGVSQPIEGHAAAFAELKSDAAPNPFKLFTFANRTATGAKLHVVEIDHQNGQPAFTKKAVDVFFPPEATNDFPVAMQVSKRYGIVYLVTKYGFIHLYDLESGACIYMNRISGDTIFVTAEHESTSGIIGINRKGQVLSVSVDENTVIPYILSTLNNSDLAFKLASRGDLPGADDLYLQQFHSLFSTGQYGEAAKIAANSPRGILRTSQTIEQFKQVPNQPGTLSPILQYFGILLEKGSLNKFESLELARPVLNQGRKHLLEKWLKESKIECSEELGDIVRQHDMNLALSVYLRANVPNKVVACFAETGQFDKIVLYAKKVGYTPDYAALLQHIVRTNPEKGAEFATSLVADDAGPLVDIERVTDIFMSQNMIQQATSFLLDALKDNKPEQAHLQTRLLEMNLVNAPQVADAILGNDMFTHYDRPRIANLCEKAGLLQRALEHYEDNADIKRVVVHTNLLQPDWLVSYFGKLTVEQSLECLREMLKVNIRQNLQVVVQIATKYSDLLGPVKLIEMFESFKSFEGLYYYLGSVVNLSTDPEVHFKYIQAATRTGQIREVERICRESNHYNPEKVKNFLKEAKLSDQLPLIIVCDRFDFVHDLVLYLYQNMLINFIEVYVQRVNSSRTPQVIGGLLDVDCDEGVIKNLLQSVTGPIPVDELVDEVEKRNRLKLILPFLQSKVEAGSQDQPLYNALAKIAIDSNNNPEAFLKENNLYDPRVVGKYCEKRDPYLAYIAYAKGFCDDELIAITNDNSMFKHQARYLVKRRQLDLWAQVLTSDNVHRRQLVEQVASTAVPESTNPDDVSATVKAFMAADLPHELIELLEKIILEPSAFSDNRSLQNLLLLTAVRTDKGKVMNYIDRLDGYDVEEIAKIAIDHGLYEEAFRIFSKAEQHEDAMNVLVEHIVSIDRGQQYANKLNQPAIWSRLGKAQLDGLRVKDAIDSYVKAEDPSNYDEVIEIAEHAGREEELIRFLQMARKKAREPKIDTEYAYCLAKANRLGDMEEFLAMTNVADILSVGEKCFNDELYEAAKLLFTSVSNYARLATTLVYLGDYQGSVDAARKAGNTSVWKQVHAACLSKREFKLSQIAGLAIIPHAEELPGLIKAYENEGFFDELLNLLEQALGLERAHMGVFTQTGVALAKYRPERLMEHLKLYWSRSNLPQLIKVAEQCHLWSELVYLYTKYDEMDNAALATMEHAADAWDHDQFKAVLPKVANVEIYYRALTFYLEQHPLLLNDLLTVLAKRIDHGRVVRMFKKKDNDNVPLVRSYLMSVQHHNLEAVNDAYNDLLIEEEDYETLRSSIDGFDNFDAISLAGRLEKHELLEFRRLAAHLYKKNERWGESIALSKTDKLFRDAIETAATSGSEEVAEELLGYFVDIGNKECYAATLFACYDLIRPDVVMELSWRHGLGDFTMPYQLQTMRDQNTRLRQLEKEVRERAKKDSDKEKLEEDAPIIGPGGLGAPKLITAGATGLAGAGMGYPNNLNGGMYMQPTGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU57</accession>
    <name>W3VU57_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU57"/>
    <dbReference type="HOGENOM" id="CLU_007392_0_0_1"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="981" mass="107591" checksum="7F1D8BB5CAAD23C1" modified="2014-03-19" version="1">MLSLPKRLIFGSQSKIDFKLSEVDGIARLYAERHIPYHDSKYWSRFLQLDSPSDVFSLLSLADLRRARRDAPENIVTLVRVLVAHLESLLLDPLFEPPPADPTRSTQDRFADRLGGLADVSKWKIPGASLVGFESANAASTAVQRDRTKEALNVVRVLTRTLPAVLESDDRSFEDSVLWVQAPGAYTESAPQTMSSQAKSTATAEEHDKLDTTAQFVIDDEDQEEGEHLEKAAAKGQDIDHPLNTTDNGSSGEKQQQQAEDEQVPIALGERLVRLVVDLLFCSGFTLPWTEDQLGDGAQTALPNRINYSIWEAGVGSSIDLPGTTRSHVSNRVEVLRLLLVLLSKSIYIPPHQQSTLVDPALKFAVQDLDRAIMLPLLCSLINTSITNARNSTSAWLGLPSVATGLVGGSNDEVRSSLVTLSLQILDVLLTYEPPLPGEADTLSLSTVGRPLPGPGGRNVFRFYLSKLHRTADFDFIWNGLAKSFNEHVSSTIQILAIPISIPTGGQGRRAAETAWQLNQVAERLVLLWRMLEHNAKFRLYVLDDARRAPELLTILLYFALTYKDNVALQGLVRMCAFMLQDVSSERAFGANLARPGSAARVQLPSRLGLVGGHTAIDYLVQAVYSLIAATKGQLASLYAPLVITLSNTAPVWRSLSITSSTRMMHLLRSFSQPAFLLSDEGHPRLLFYVLETINAVLTFGYTANVNLVYSLVLARQLVAALEAFELRKGVEEVWKKRRAVGTDTRDWFQNAPRLEKPPLPRAEDSATSPEGGDEATGPSAVEKGKMRRISTSSLEAETASAWEGELSKYPLSVVEEAAARYIGKNGFSPTAAWVESWHAGLPLSTLRVVIDRLVPDVERIAAGGGVRTGTAEITGGDVDARVLAFLREQQMAEYLPPPEGGIHARGWQWTDHATVWLRSYLWGTIYVAALLPFGLWSDTDVRLFRIHGRDEAGQPAPTQAAAQPQTPTTPSADTQSTTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU89</accession>
    <name>W3VU89_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WLM-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU89"/>
    <dbReference type="HOGENOM" id="CLU_040077_0_0_1"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metallopeptidase activity"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="484"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="169"/>
            <end position="263"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="278"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
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            <begin position="242"/>
            <end position="253"/>
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            <begin position="303"/>
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            <begin position="442"/>
            <end position="453"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57521" checksum="758E726E20870644" modified="2014-03-19" version="1">MVHLRLNDPDTSRNKQINYITALPRYADSEQAHHRLLQLAAQVQPVMKSRGFQINSLEEFEWNREFAGRNWNNGETVELVLRRQDGSFAPLQWVLMVFCHELAHIKYMNHIPSQHGKLDRELRNECRELQARGYYGDGFWSAGQRLQDNGFVAGDGLNSLQGLPEYSCGGAFRSKPSRRQGNKRRRTNAASAPRKRGFKGPSLQTGAQTAPNTKGGRRVQAPLPGSGSRVDGMNHLPKASAFDSSYKQDSNSTFRKRTQTASARELRAQAAMRRLNALKTEEATVKPLTNQEPFWPNEKRDSIGSSARSSASVDGGGHVKEEAGSSHGDSETETEDEEDTKDDGMVIHLDDSSEDESSVRSSASVTKREAEDWLAGSSRVKQEPDSHPHQTLASKESQEQRLERARLYRQHELQQGGTMRPTNEDWLDFCSIARLTNPSSIAEDSVGSATRSNPIEILSSDDESSSVSKTARKAAPKLSSRLDQTQSWSCRVCTLINSASALRCDACLTTKGSFLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUG6</accession>
    <name>W3VUG6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavonol reductase cinnamoyl- reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUG6"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="344" mass="37288" checksum="8196F168F7D28076" modified="2014-03-19" version="1">MSVQELFLVTGANGYITAALVRQLLQDGKRVRATVRRQQAGDDLRAALPASTVGKLELAIVPDIIAPNAFKETLQDVTHVFHMASPLPGEGKTDAKRDFLDPAKLGVLTLLQDSSVTPSVQKVVLTASVASILDASRVDTGGSYTEKDWNPITYDYAIKLGAGLATGSTNPMIIYAASKTLAERAAWDFVREHKPSFAFAAVHPGFVVGRPVTGSISGSNGMLWQALTARPVQESAQPMALVDLEDAVRGHLRAMQRKEADGGRFLLVAGQPLTHEAINWAKDRQPDLPFDRVDIPADAEERKRKFTGYDNSASRDVLGIEYKSLEQTIGDYADWAATAIKSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUJ6</accession>
    <name>W3VUJ6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241826_0_0_1"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
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        <location>
            <begin position="511"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="809"/>
        </location>
    </feature>
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        <location>
            <begin position="927"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1178"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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        </location>
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        </location>
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            <end position="547"/>
        </location>
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        </location>
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        <location>
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        </location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1527"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1687"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1722"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1761"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1796"/>
            <end position="1806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1837" mass="194336" checksum="D3C84B0D190BF1A1" modified="2014-03-19" version="1">MACLSPGDARPARVPLVDLQPIAIAACNPNSTGLHSHQHPQPPLPLSPAGAAKTHVQRPAAGLSSAKHPDTPHRRVPILLVRCLGAALPPSSLPRPRTAPFRPPRDNVDDAHPPLVLIRSNSDPQLLYPLPDRRDNLVCAYIIAASPPRRSSLDPANMSLVHPQSPAKPSPDSPSLHTDSISRSSSPIMSSQPEHENDSTMLTTFDSSITPPDSAQSPASLHDKLAASAPAQPSRLASAAFPTTTTTKPVAIGPESSALRAAEHGVSPVISALRSPYPASPSYFVTAIPPQDFPTSSESSNAERDRLQRGSLLPLYPTLGGQLWAISREFALPSVGGLLLYLADDGQGNRGPRIGDAAWQALWSRYFADDDLSSTSAAAYKPPPNFAHSRRSSEAAADSFAHPSSSSSSAHAADLSRSTIAEASSSRPSIPYVSYRPSPRTDALGFARRDIHTDWSPSVRSAAAFPAGHHQAMPPPPPPPLPFPSLPIVARIEWQVDSAKAPWWPSWVASRANPRERPSHPTRKSMHLARSLSQSQDDEQQGDEPQDQSDRAIAKDVAPNSQHELEAQDEISEIEQPTQHETQQRPASTASSHEAASVREAIAHREAAADAGVEAAPLEDTAPHDHPLQLFQQRSSQSSITASLPEEEPEIGKELLSEVRYEQHAPMPTLPTRSASPSDEPLQSQRASILSMSSGASASRPALSVSRASIQSKPVVPASASTSSSSELQRASLQHQLTRDALMPSHRSTSGQSRTGYSEILDAADEAETEHDISFGNEPLSLAHAGDYSALPDSPSSAAHEITASQRGSAYEPKGFALRHSFIVDAGDEAMWQDLQHHGMDPILPAPREPSHAAPSFEHEQTPAAFDADSRDFEMLHAAPFEAVTAQPPQVPMQQVPTHHHDSNAANDVYYSPRRDNMARIQSWIGKTPTGRPNSSGAFDDDFANDFSHGEMQLPPESDIDEVVGLWASKVRQDPYAVPHITAPSPSVHADEDAAQAVVGRGHEPQFHIPSAEGHDTDANLEPGPPAVSLLSPIHLDAAAFGGVKPQLGGLTASLSPQLLSPTAVGDAFNTPRAPPSPRSVSTPIFQHHPPSSPGSLALPQDRRPSSVSRRSSGDLSDSLEDMQKALELLSPGCSPNPGHGHSPDPAGRKMSSRDSLAYARSLSASVTPSPKWIARAKAATAKSRSNARSPFDRAPVSPRPASTSAVSASRFQSPRIGMHAPLSASRLVEFSKADAMPRLARTEVADTESMRSRDSNPEAAAVAPSAGAEETLTGTEDMAESKPVAARSVEPEVAQEHADAAQEQTEPIQAGTPKASNQTVEDGESSATEAAGAVATAAAPASAVVAERAIDAPEEGSVAAPDHDGDDTTELAAFLGDDHDDGIASIQRFLRGKVVSAAESEASITQDLTVSGVEQPQTSSADGTIIERSVSIDSDMNSVPQPSAPSEHADAADVTDKQHEHDEHAEIQATQDDAASNERWSQVSYATGKHTSQFPSRLSLPSASSRRDEHPDARTPNFTYDALLSSEPTTADTLLSSTSRDDERLSAASDVVKAYLSSSPSDEAFFKSPGPSKLESADGPRLGQGAASALPQPMWQQDSAARDAAWPHIDRVPEVKDETSQGGGVPVLAYRLASSPVHASPFGINRPLAGTHDYSLDEEEIRTMNEDTRAAVREALSQSTSHHVNLPASVSAPLSPKSSTSPTLSSHSSLGDQFRRRGSTSSLNLTSAGAGSGSNTSSPNLGGTTKRRPARLTLDIDGLARSPPAAASRRLPSTSPRSRFGQLPPSPSLHPSYKAATSSPLSTSFPIMGAHLGSPQGKHFLPSLPSVTSIEAELAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUN8</accession>
    <name>W3VUN8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUN8"/>
    <dbReference type="HOGENOM" id="CLU_417445_0_0_1"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF15">
        <property type="entry name" value="VELVET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="392"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="657" mass="70723" checksum="E487AB259514922D" modified="2014-03-19" version="1">MLEKSLLSNPGLEFTARGLLAPHQALPMSPVGLVSPAKNVSAAAFLHGNKDGRRKVLHQPRDAAELGCGSSRSAIHKNESSLSPCEVIQPASAVADEIVLTPAKASGLGSAHLQQQRPRAGRQNLPAALRLPWPPSLRFCFGSSRESRLVSRTSERAQQDRFKDLSAPSSTPPSTAPTKTATTFANLSHRAQIASRCVLRKGQPGHLLSSPRQSVALIIRPSTPSFPTIIRYQVQSILCPSGVSDLIKSPCAAIMPEMLAAHSMEAVKHSRGTPRPQHGQALADNWPHDLWRNLVCLRRVFIDSSPTLLSQGRLNRQRRHQSRQHQLTESERPGSQEKNPPAPSSSRAQESTSSAHSSGSYLSDRSTKRRLGSEPAGEALPISKRAEKVNEGSSLTYKLVLVQQPTIGSAFEDNLLGRLGLAPPLIVELQVFRDGKISDANADLPFLICQCSLLDEQGRVADMVDQRVGSASQQSQEARTAPAAVSAVPRRGRSVRNKISHRGGLADGTVTPLSLDSTEASTSSASEGTLTPGTGESSATQLSGRNSPQIVRMLYGTLAAGPQQYNSPNADEEEKAYFFFPELSIRTPGRFKIICTLLRLSLPGMEAAEVGSLASVETQTFEVVKRTDYSAPYITDISRHFARQGVPLLLPPGVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUU0</accession>
    <name>W3VUU0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUU0"/>
    <dbReference type="HOGENOM" id="CLU_1094686_0_0_1"/>
    <dbReference type="OrthoDB" id="10583899at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="254" mass="27865" checksum="1BEEC01148896B10" modified="2014-03-19" version="1">MADATLAWAGGVAAVTAAAVAVAVAVAASVGWGVRRQKDSNQNNRGGTGSSKHQQHEQHKAGARRRRRANTQDKEAEAEAEERRLQLQIDRRSNRTQACGKGRRRQQQQGQQQQQPQQHVRPSMSILNFTSLLSWLSLLSLLRWDQPTKQRTPAESQRQSIKLRDYIPRPCGQAAKSHRSNAFSFRWDGLNLNCGIASDPTAKPASFGPVSGLGLEPALPPQLVTQACMQGKRATGFIASSSHHLMERAQGSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUZ7</accession>
    <name>W3VUZ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00036</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUZ7"/>
    <dbReference type="SMR" id="W3VUZ7"/>
    <dbReference type="HOGENOM" id="CLU_013253_3_4_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833315" description="Peptidase A1 domain-containing protein" evidence="13">
        <location>
            <begin position="23"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="107"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="138"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS65310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="418" mass="44660" checksum="6ADDF26588CB5B09" modified="2014-03-19" version="1">MKLNLSLTFVAALATAFAGVEAGVHKAKLQKVTPSRELTLEGLAAQAEVLQLKYGGGASKKQAPFAANPEHDFSIQPIAPKDSASAWYAEAKKGHGVPLTDFLNAQYFCDISLGTPAQEFKVILDTGSSNLWVPSTKCSSIACFLHKKYDSSASSSYKKNGTEFKIQYGSGSMEGIVSNDVLKIGDLTIKGQDFAEATSEPGLAFAFGKFDGILGLAYDTISVNGIVPPMYQMIDQGLLDAPQVSFYLGSSEADGGEAVFGGIDDSHYTGKIHWAPVKRKGYWEVALDKLALGDEELELDNGSAAIDTGTSLIAMATDTAEILNAEIGATKSWNGQYSVDCEKVKDLPPLTFYIDGKPFKLEGKDYVLEVQGSCISSFSGINLPGPLADMLIVGDVFLRKYYSVYDLGRNAVGLAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVB3</accession>
    <name>W3VVB3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVB3"/>
    <dbReference type="HOGENOM" id="CLU_011427_0_0_1"/>
    <dbReference type="OrthoDB" id="2507795at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="786" mass="84218" checksum="5AF203C484608793" modified="2014-03-19" version="1">MDEDPDFDYEMEPHGADALLQSGQEEVMEDAGSDVVIASIASGQHGSEDQASLDIDFHDTADLHQQSQAITTQAGLAFPTPSSSSYMENAPVTASISAFPQAFPHKAEAAEQAAPLGGSTIFSPPPSEATGVHSSFASASVRPTSPLITSHEQSSKMPDGSQEPRHESLEDHGIRAPLAQEQLNLGVSSTTANDQEEREEEELDQLEGAEEGAQSTNVAEDGDHGVQNDAQQGYEQMEYQSVGAVRVNFNGQDFVVWPATEIAAYLAAPDAAQGGDQEEHAEEELLQIEAPALEMKQDVLWQPLDSFFAGLREKSALGDFLDESQELHLAFPDLDLEISEDNFYCREITLDDLGQLHSGLGLATSLHIEVSERPRFITKYNDLAQQVAGLLGHQLQHESDDSEAEADTSEPHNVAIAKDDASPVATSGLSTGRSDPAEAASNDAERQQSHANGIPAAVESEQDASQAPLESPQHQNKNGHGADDIDQATSIARGDAAGSIAEASGTGQPHPVVVETASSEALDEQDELDELSHVGDGAQGHAEEHQDEAGVAEQEQGGGGCEEEVQEEGQGEAEPRNAHFEEEPEDGDDGQEGSEEAAGIGEEGGEEEAEEVLAYGEEAYEEEEDEEDAYEGEEQEWYEEEEGEEAYENEAGGFDPEAEQTFYTTLSDASDGEEDELDEAPQQSVGEGAAAEDGAAVGAELTNGEANGHEPHIWQATDEEQILEYTEEQDEDEYGQDDASALGASTAAHSHPQLKRLHADEDDENDDEAQYEEGDHEAESKRAKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVL0</accession>
    <name>W3VVL0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Het-C-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVL0"/>
    <dbReference type="HOGENOM" id="CLU_010063_2_1_1"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1025" mass="110191" checksum="5F67750AC6AFAABA" modified="2014-03-19" version="1">MADEALKERLKLLRQGLQSSAQPAAAPSSLPPRSSDLRSSNTSTPTQLNSTHRSTNVTPAESADEDALLFDRLRKLRTTQAPPTDREHLGKPPQRGQPSDAVSVPARLSEQDEIDALIRSTQDQVDLERSCYPELLDSNDAQSDHLSDSELSGDIDNLTRDANNIVQAARDEVSLEIRSPVSDTPDPPQSTREEEPAMMATHHEIESALADASKDSELFASRDAPVDAATASAPANQAKGRRNWLGGRFFFVAMVTLLIVAVSSIPGAHAFGAGNIPSFAYMEGKAFRHGDIEDILEELAKKVGGSLFGAAKFGGLDIKRIYFGNWLRDYSQAMDVAGLQKMNKQAILNIVMVLGFLAHGYATAEFQVTDDRLGVYLPEEHLDNPKGYAEGKDARQYDPRLREPINPQELEIDPRSGMKNYLANESGNWRTGSGLIRRTLVRVIETGRRARDSGREADLYEAYRLLGQALHTLEDFPAHSNWTELALHRLGHHNVFLHVGDNVKVRAPDGTQVAPIVTGTFGGADFMHSLLGEAQDHLSEASISDLNKAMDNAKQRSRGENRSPVQDLLGMLAKVPGGGGDSVSRDLQDVSRGPATDPANMSPQEMYANLWKILELRDRIMKGIEGTIEKIPGLSSLVEKLTNELNVFVFTLIEPYAKPIMQQGMSAFKLGSAAVINKEEQFEVFDNPNASDPTHSMLSKDHFGLILNEVAGNVAKIIVRHTVTKVVKAWDDRGMDPNHVADECLAPMFHPYWFNGQAQVQKEMMDYVSEWARQHSTEIGRLSKQSVRNHTNTRSGKAEPHTHGSDQPSIGSFMGGSSSQAAHNFSSNHHYGGGGHGGGNSGGGYPGSGGGGGGGGGGGSIGSQMAGYASNYVSNQVHGFVGSHVPGGNNMFRELPEGGNDGGREQGRRHEQGSSYDNDRPSFPQAEPTGHDRYGSHESGNYSAPGYAPPGGFAPPGGPPPQGGYGGPQGGYGQPEYGQQGYGQQGQGQPGYGQYPPPGGPPGPQYGQGGYGQQGGYGGGYGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVV7</accession>
    <name>W3VVV7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVV7"/>
    <dbReference type="HOGENOM" id="CLU_004931_1_0_1"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="85"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="655"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="920"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1146"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1172"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="784"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1197" mass="128294" checksum="60B663041F4F04E0" modified="2014-03-19" version="1">MAQVASSSKLPLALPANDQHHRHIDPRTDMVGSSGAVYSAAAHGSAALKSDAAPPSAGPSASSSLRPPEMPTTAASLMREGPRDFTVIKDVGDGSFGTVCLADWKSPLPSGTMLSPMQHPTTRPEYIGKRLVAIKKMKKPFPNWQECMKLKELKSLLTIPPHPNIIPLYDAFLMPTTKELHFVFECMEGNLYQLTKSRKGRPLAAGLVASIYEQIALGLDHIHQHGYFHRDMKPENLLITTTGLADYPQLQPGAPPEKDVLVIVKLADFGLARETLSKPPYTEYVSTRWYRAPEVLLRSRDYSNPVDMWALGTILAELVNLKPLFPGHSEVDQVLQICEVLGDPSHSYGHDSRSRRNGGGPWDRGIRMARSVGFQFPICKPVKFSRLFSDRVPRSLVDCIEDLLRYDPKARLTSKDCIEHEYMKMDAPRMRPPQAKPVVSATAPLRPQQNFAANAGVSRPVPPSHSTPLSPQASKPPFGAAEPNLKPMAMLRQPNGSAVVMVNGSRPTDTSDPAASANASPASPMQVDSAEMQWAPSMPSMQRDVSLSGYPAFPDSASLYAQSSSTHHDDPSSGAPSSDATVVLGNASAAPSASQATDATLKHGDYRQGQTLQAHQYEQYQRQYRQDVANLQRDAYDDPQARGFAPHAAGYPHVGIDRGLPGAMSSGDLSQKNESNASNETIGSRDKERRRSKGWGLNISSVFGSSGGSTTAVGSSGGAGGNTTGAAQHYGSPNAAAARMASNGMMPHAQQDLRSPMEPTPAQKIAAEHSGAAPQSNGAPSKPVDPKKAKKEAEKAAREAEKARREAQQKAARDRARAVMQKRNQLLASSNSKDPVEWLAGSIQADEPYRTGPSEKARGKQPAAPGSQLSPSMPSYGSGEFPRSPLQPPIHGLSPEYGLAANPAVTGNMAWRGVGATRYSRSNKARRREHDDDHSMSSFEDAVDPRRASMQSYQTGDSDPGPGTGSHLPQGHHIQRASSSSSLASAPSFDQRRFAPSLESHRNSQETRSISSLDHQLITNMENMTAAEARTRTPGNVSPGPAHMVGARQSLSRQSRANSRASSTSAHRQGSASPLHHASGIPRFHPYHGGAGAAPAGFHPNYQLPPLHQSLHNAIPHRGDTGGDGSAPQAFQPNAGHAQQQHHINPIFHVPSGNGGHGTTLPPFSSIAASIDASSTDDKTAQMLYAQARASGPLPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWD5</accession>
    <name>W3VWD5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWD5"/>
    <dbReference type="HOGENOM" id="CLU_2159504_0_0_1"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="111" mass="12195" checksum="9A09BCE2F027DCA4" modified="2014-03-19" version="1">MAFFGFRAYPTPILKPMWPFFIAAGVVFYGVNKLQDMAVSTEEASKDPRNPPEGAQGGPPLSAKRRQQQHTALTAGLPLSCIADHTKSRPQLDTLQYSQHVSAIPRCAMHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX53</accession>
    <name>W3VX53_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX53"/>
    <dbReference type="HOGENOM" id="CLU_050886_0_0_1"/>
    <dbReference type="OrthoDB" id="2524732at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40562" checksum="8941377CFE4B87AE" modified="2014-03-19" version="1">MGLPQRRSLTVAEPARGSLPGAPHPNVMLVIRFLVTGLVALLSLATAIIAILIVDFYNSNDPIIRPSWGSLIFLIILGLFTPIIYFGYNIFLPLMPFINYGDFLYSLFMVKIELLLQFAMCVLWVSGALAYANDLRGRENCQFDGYWHYEKPANFNHVCDLFEYATGFAYATFGVQVFLFVIELLYGMYIFLLLDQESLNEPHFEWGRRAYNYAQQSKQQQRQNAIGRSPVRATAVGGAGGAPAASYRDTGRRSPGSSVSSSAGVGSAAQGRRGAAYNDPDMESRASAPVSLGSRGRRGVAYGGMVDEDEESQIGGRPLSQSSSQGDVGGGPLAAAAAAGGRASSRGGSKRGSRRGPLSDEESGWHLREEDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VXA7</accession>
    <name>W3VXA7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238337_0_0_1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="219"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="1060"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="727"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="958"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1152"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1358"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1603"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="775"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="977"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1152"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1358"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1389"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1427"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1458"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1503"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1632"/>
            <end position="1646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1655" mass="164221" checksum="7F4DAE5E88C381E5" modified="2014-03-19" version="1">MADTAKSPAPQPSPTRRPPSPPGIENPHPIASTSAQTLDALPAVPSSSASTTNPAELNQLVTDAAAPQPTQLGDNAAIVDSDSISASLQAATAGLNEEDAKLLASLAEGNGLLSHLSNLAAQNGSSTDLINAYAGGLNLDPSSAMPFSTDPAALNAAQQAFQGAVDLNEALTHQDMLWDDDAFDDLEPEDEDGEDQGPIQAYAKLEFPGFSYYIQTLDVTIGRRPGQLQPNQRPGAQPPQLPNAASGLSQAHITSESKTEGDVDVDLGPLKSISRLHARIFYYTGPIHPPNTAFLNGTPAHSRASSATSAHQNVAPYRITSPASLNRVNGAHLAGTDSTSGSDLYQASLGAEPEHGDGQFVLMVVGRNGAFVDDVWVEKGGLVVLGKRTKIQIAERVFYFVLPPPPGAAAHSDDGDSQRAHDSESDSLSDLSSEDGSDDQDDDDQEDDEEADSSSSVSSQEGEDDDYDGEDVATANKTSGRRKSSASKAEADKPKRRLVLKPKSRVGKPSAAANSADESGADEPMVEESDAVDAGRKGKGKAQARGKPAAKTTAAALANRAAGKGKGKGKGFTRGKMPTKGPLPDSRPGGDDSDSLGTPSAGEEHSEDEDQDDGITTPPPPTTGKAGTAAKRPGKSVKGLKGAQKAKAARGSKANAAPDQGEASDDDVAADAPDAAIKKESPTPAWAMGAGVAGRKRKRGDAVADEEPALKVGTPIGIEALDAAKRAKAAKARADASSRASASPKKDATTVASAVADDDDVVMLDVKPATPKPPAAATSAAAAAADTTSSATTASKTSAAAKPTSAKAAVTTANKAVSKAAEATTPASKPAAKAKPAKPKAAKPKKKKGAAADETPAISEAPGQPANATPGVGPGAASMPVGAFPGAYSATSMYPSSVPYDPSSANAASTIIAAANAVSGSMPNYGQPQAAVLPHAVGQMASPLPMIPSAVAGRNGGVPGALSSLPTSGPTSTQPTVAPSTSISNASGSDASTWPTTASIIASAASLANAAKQSQTPASNAANNAASNAAAGNNAGNKTGGAAAAPAHATPKPPPGPEDKPDLSNIELISQALRSDHCAKRGGKLTLQEVYEWIANRWIWFKRNGRHTGRDWQSSIRHAIGSSRDFTRIPRRSDEPGKGIFYTMSDSKLAEEHRANLAKQKEEAAKAAAAAPAAPANAGPAGSLLSGGAPIPGADSQTASGGSAAATAVAGAAGGAAAGSLPAIRIPLIIGTPPSSATAAAADKPKAAPGTIESLLETPPIVHHDGKLYLSPQVFGHLNAGQLAQIEGLGAQQALQVLQAYLVTHLKERMRVQQAAAQKKDVDAAAAKPASTPAKASSAATAAPAKAATVAPGVTGAQAGSANGHAPGVRPASSAAAGPSTVAATASLPRPPVAGTPLLPKPVLPSPVKPSIPTSAQSNGAAAGVKGTPSASTAAASGPAPSVKAPVAPATGSKEAAKSNPAVATTAAAGATAKTPVLPSTPLRTSAAGAGGAPKPSTPAPAPATKAATPAPATPQSATTPAKPASSASATASTSGTPNAAAAGTSATGGEGDDPLSALSALAAHPEAAALIALLRKQQEGGASGGKQMAKLTPGQLQLLQMANKLAAQQGKKKKKKAAAGGAGSREATATPGPSGPESSPAVGGPSPSPGPKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD81</accession>
    <name>W3VD81_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD81"/>
    <dbReference type="HOGENOM" id="CLU_131678_1_0_1"/>
    <dbReference type="OrthoDB" id="2542148at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832862" evidence="1">
        <location>
            <begin position="22"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="181" mass="20606" checksum="EA90843FDDFDF0F2" modified="2014-03-19" version="1">MVAYSIIAVLGWTVLVLGALAVQQPELEEHEWPLYRASLAHIRSTFEEPRPAPDSRVQYYPHLLAGQATAERDAWNFAHEQGMGPFHVGYDYNRRYAYVTTKIPRESTLGRKWGLGQPQISDLGFRRTKDAYAYWKVSKRGAQLLRLDLWSSGSHAAQTTSWQNVYRGLSRPLFGCLSCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDI2</accession>
    <name>W3VDI2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_06626</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDI2"/>
    <dbReference type="HOGENOM" id="CLU_006308_0_0_1"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="11">
        <location>
            <begin position="611"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="562"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="822"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="902"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="830"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="912"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="946"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="986" mass="110299" checksum="EEF2B32CA272C7C6" modified="2014-03-19" version="1">MAGSTEPAPAPTRDERKACWSHRDVYFACLTQKGVRVPPGTDMSDGRGPIGKAAKEEQEALEREKAYTADEARKQDPCLEARQGYEANCARSWVDYFNKRRVLEQRQKMILRRSLRTLGTSEALDLARIQAHTRWHPSIYYSDRDRLPAPFELAVLPFGAMPSRERSLDGRSSASSSSSRTRSASPDEAAALKRKRPISRSPSAASTGSSRSVSRSRSPPPRSRRRKSSRGRSPSFSSDDDADKRDESARAAATQQTEAKAKEVAAKGEALRSTLAKLSATKAGGAYIPPARLKALMAEAAAADPGSVEFQRMSWDALKKSITGLVNKVAAENIKTIVVQLFGGSNLIRGRGLYCRSIMRAQALSLSFTPVFAALTAVVNTKLPMVGELLVIRLVSQFRRSFKRNDKTVCNSTAMFIAHLVNQRVVHEVLALEILVLLLEQPTDDSVEIAVGFMREVGAFLAEEAPKANNSIFDRFRAVLYEGDISKRVQYMIEVLSQVRRDGFKDNLRIPEALDLVEEDDQITHSVSLDDQLNVQEGLNVFKNDPDFLENEERYRAIKAEILGEDDGSDDGGSDADSETGSSSDESEAADPDAAQRQLEIHDRTETNLTNLRRTIYLTIMSSLDFEESVHKLLKLEIPEGQDIELCNMIVECCSQERTYSKFYGNMGERFCKLHRKWSDNFEQSFRNYYDTIHRYETNRLRNIARFFGHLYSTDSVSWAALSVIHMNEEDTTSSSRIFVKILFQEIQQQLSLKTLAERFSEPSLQEHWQGLFPKDNPKNTRFSINYFTSIGMGVLTEDMREHLKNAPKILLAQRQAALAARGSDDSDTDSSSVLSSSTGSRSRSSYSSRSSRSYSSRSLAVAAVTAAEDLEAEASAEVDREASLVVHRVAAAGRLVQGGVADVAAPARHPTRPDHDRIRGHDRGRTRGRPHVQDRTHDRRYRSASRSERSYSDAEDREPRSRPLSRGRRDSFSSQSRTPSPRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDS9</accession>
    <name>W3VDS9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
            <ecNumber evidence="5">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_06292</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EC" id="5.3.1.16" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDS9"/>
    <dbReference type="HOGENOM" id="CLU_039330_0_0_1"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="15">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS59768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="508" mass="55534" checksum="84D96DBB474BCFC9" modified="2014-03-19" version="1">MSSNSASSGSSGLVLHHLELSRSNRILFLLEELQVPYEIKHYKRDPVTRLAGDDLKQVHPLGRSPVLTDGVLTIIETNAIVAHLLTHYYDPARVALGPGLGEKTQASVDVGGWTQFSEASIMLHAIPLFYALKSGACTEDGSAGIERASARGIKADLAYVEETLQHNKGQLVKGYEFTAADCAMLYSVDMLAHILATRTPGWRKNLGLEIGPATLAWMSQCKRRTAFQAAVRKEGHEGQDWLSSFFARPPARKSVFRPCIDLHEGVVKQIVGGTLSDTDSTLRTNFVATHSPSHFASLYREHNLTGGHVIKLGPRNNEAAASALSAWPQGLHVGGGITGENAQEWLDKGAEKVIVTSWLFPSCQFSLSRLEQLSERVGRERLVVDVSCRRRGDRWVVAMNRWQDMTDMEVNKASLDLLAAHCSEFLIHAADVEGLCQGIDQELVQKLGEWVTIPTTYAGGARHIGDLQLVDRLSKGKVDLTFGSALDIFGGQGVTLDELVAWNHAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDX3</accession>
    <name>W3VDX3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDX3"/>
    <dbReference type="HOGENOM" id="CLU_380335_0_0_1"/>
    <dbReference type="OrthoDB" id="2554458at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="3">
        <location>
            <begin position="494"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="739" mass="81071" checksum="34E135F79800875B" modified="2014-03-19" version="1">MAPKKKQRLSDGVRASTKPLSTSSTRSRTRSASVAPPTSTTTPPASKKGKGKGKQAQTDKPPLKQEQDALARLSPVWDAEAAPKMTCWVEIPLLHPCPTEDELLFVRPRTITEPKAKGKQREGALLHHLDRSASKVDPFHFTDEDLRDESEGRQLYAFQPKPPKPRKIASPSRTAQPAHDGLEDLFLGSHAGPSTASAQPDQTRPLFLHGDSGDEDARRNGPPPRTKASASQAEVKAEPTTNGQHSNNGQTSKPSKSDKSRSQSAGAQPPATSREKKRSRSVERTRDEGVGKKRGEDIKNLRSELNEDAFARSTGPRHKEEYRTKLAALSQARKKAKLERGESLSASDSDQAASKSRQNGRATSVSSGSDSGSDSDTSSGDSSESSSSGDFIVGDDQIEYDEGFDPNDAEPAPRPLPSAAAAAAAMPKGGKYKRDSDGRIRLMPIHSHAAVSGSSSSVLAEHGLGLGQRKGLDELCLDWLEWAVARVLVTWSSLSPADRERLERNRAALKSRTRSTEESVGSVAMRRQFKWYLTNYPKMHVEALFTDEIDRFGSLAKQGCGICHRRSQKPQARVMFSGSRYNQQTLAPLSSHQDDSSSDSDSEASDRSDDTETWREAGRDEKGRAGHVFFAGNHCAHRAAVLHALHHWEWTAMQTLARHESIRYIRRQLWRKSRNGRGKDGCPGAGAYEVAFCITEMISPTGRCTWKSKPDTRATSELDRLRRRLKSLTDQAIAVNRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE12</accession>
    <name>W3VE12_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_06262</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE12"/>
    <dbReference type="HOGENOM" id="CLU_002556_0_0_1"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018074">
        <property type="entry name" value="UBQ-activ_enz_E1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00536">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="12">
        <location>
            <begin position="890"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS59740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1020" mass="112498" checksum="11DD8356913F40A2" modified="2014-03-19" version="1">MAADDMKVDQPEQAIDEGLYSRQLYVLGHDAMKRMAASNVLVVGLRGLGAEIAKNVALAGVKSITIFDPTPVSISDLSTQFFLRPEDAAAAVRRDHATQPRLAELNTYVPIRVLEESELTKDVLARFQVVAMTDALYAEQLRINDLTHATSTHFIGAEVRGLFGSVFNDFGPDFLCNDPTGEQPLSGMIVSIAGEDEEGLVTTLDETRHGLEDGDYVTFTEVQGMDAINGCQPRKVTVKGPYTFTIGSTKGLGEYKRGGIFKQVKMPKQIAFKSLRESTAQPEMLIADFAKFDRPAALHAGFQALSQFQQANGRLPRPRNAEDADQVLELTKRIFQASGQDAADLPENVVRELAFQAQGDVSPMVAYVGGFVAQEVLKACSGKFHPLVQHLYVDSLESLPDSVPGLPESEFAPVNSRYDGQIAVLGRTFQDKIANARQFLVGSGAIGCEMLKNWSMMGLGSGPDGIIHVTDMDTIEKSNLNRQFLFRSKDVGHFKADTAAAAVAEMNPDLKGKIHSHQNRVGPETEDVYGDEFFASLTGVTNALDNVQARQYMDRRCVYYEKPLLESGTLGTKANTQVVVPHLTESYSSSQDPPEKSIPVCTLKNFPNAIEHTIQWAREQFDELFLKPAENVNAYLSQPDYIETTLKSGSGAKEQLDQIKQYLVDERPKTFEQCIYWARMRFEENYSNVIRQLLHSLPADAVTSSGQPFWSGPKRAPKPLTFNVDDPMHLEYVMSGALLHAENYGLKGEADAALFRKVLGSMTVPEFVPKDNVKIQVNDNEAVNNAGSGGDGDLTDITSSLPEASSLAGFRLQPIEMEKDDDTNHHMDFITAASNLRATNYGISPADKHQTKGIAGKIIPAIATTTALATGLVNLELYKLLDEKKTIEAYSNAFVNLALPFIAFSDPIAAPKLKYNDTEWTLWSRFKVERDVTLQEFLEIFENEHGLEVSMLSSGVSMLFSAFLPAKKREERLKMNMSTLIETVSKKPIPAHAHWVIVEIMADDREGEDVEVPFVAVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEG6</accession>
    <name>W3VEG6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001128_0_0_1"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="10">
        <location>
            <begin position="1943"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1806"/>
            <end position="1829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2247" mass="240734" checksum="3B199E1C1DBE1907" modified="2014-03-19" version="1">MASSLAAQLANVRSHNASRLASSASLVKHTSYLFPPKTAAQQDLFTVHALGASGWTELSAQDASLQQWSSSSLLFGEESRGMDRLMLPKEDNDAIDKAVREFLYLASPFLLSKGASKCLEWLVRRFHIHEFSVQDVLAAFLPYHDTQQFARMLSIAKLDDKPHLQFLLSIKKTASPLPAGVLHAAILAPATTTSSLDLLRWISSLIVNDTTTALHIAPHRALVNFWTSTLVQVCAARARMDETQHVSGLSKSTSNSKKSAKTRAADAQAILTILLPAAVRVAATASLGQDAQMGGFMLLCTIAQSFPLSKEAIQGIFTSLAKSLSSSGITTNVNRALISCAFALCASSSVATAPLAAQSTSADRLIPDSLAALLVASPEAGSSISALAKQYDGRAFLAHLLAALSARLSQAPSADLLSTLLRGQVVHDELAIQTSELLLNLRLGTVVGSSQALEVAFEAHFKADMLVDAHKNRLRVLQTVRTRKPQVFDAALRNCTRKDQAEARVAAIWQTVQAVLALESGTSLDDASSGRLDGQGQSDILWLSIHSAEASQRVLALKQLYKQVQDGRARAEDTMVREALHARIQDSSVDVLQVLYSQPASLLDAFDNETLLATVVESLAEDGISVDRFSQHIQFLLNAYLERHADAQDAVAQRAVWPYLLQSKARAALAKAAATTITGSRKVKGLLNSIAPSLNASMAAAEANDAVAQAIAAYIFSLAEAERANWVAFLESTARPIAKDSSLAGAAMSRDLALLSLLHLADKLEGHDFVTLADTCLHTIVLPSISAAGALTADQAKLLSTAGLRDTLEASPHSKQLAELSRTAGTEQSAMLLVSHLLIQIVRCVQVPAFDSFVTSRVSAEVAAAKSLLGALYWVVNTAPLPSSVPKLLLQILLVKTGDASLPFLASIWANATASYSAAVRLAALRHADAYLSAQAQASAQAKAKDFQAVVPLLLAALADSEAAIRLAAISCLEHILRVSERIAENAKALKKKGEEAEIYGYESFYGAAGSDPMQYIDLPALVHYLEKLLERKSGFRNDATLLPKMQAELLQISRHDGRKEVGEKHAMVCFILSHILCLDTAANRLVLVQSLAGVSDAAKLDMLLPLIRNVVQGSVAAATEGLRSIDERELYLELLFGAYDRSSRTVVETATTGAWALFLEAVSGKDGKALVQKAAVRALDKAGFFTTLSPAMRKEIYLHLADIVADPALPAAPEVGSALRELQLDSAILIAVFSELRDAITTKALSGPEAKRARTLLTPDETMTRTCAVLVAVLESAVGSKLVCSGMLLYELFEVLRVAVDLHSAMLAANAEQMLQLAMACIEKLIDGSIKAGAAVPADVAQALRADVIVSVIKCSNNPQTFQHALLLLARIANVAPEAVLHNVMPIFTFVGATVLQRDDAFSFSVVERVLQSIVPALVGSLKASDAAKQRKFALLCEARMFVRIFTDAAAHVPRHRRQTFFRILVDVLGADDFAAAVAMLLVDRSAHKIVKQPRADAEQTLQLPLSVVSPHSAMVQVQVLHQVWEEVLRIWAHRAETDALSEHVFLDRAGRLDKEHVDHEAEPLRQIQALVMFIRQVLTSKAFAEEVGAVPEDEIGPELETFIQLALETVARLRTTQPVIAALALELLDKAMPFSPVTNVLAVVSKLVESDDVPRQTSGFSLFASRVAAMPANSQDRTTVATFTPVIVKAAVEVVEASLSTSQRGSDAEALRQAALDALKTIASSAQPSEHGSLASSLPALVKLGQAAAKAQDARSAVPAAARISVFSITRRLTTKLGPRLIPHIAALVPFCLGVVSRPSATVAGAADSDSDSEDAQDTAPGAAKSNVSSLRTGALDTLTGLFGSVPTFMTSYVGAVIRLAVSPELKAAIASASGSSTASERSLTQLVSTLVRKTPAKEVFEATFRVWDDEMGAEVPADAKAERLVGVAEFLGRALRQSDREAISATYKLVYRFLLRALDLRRTSLGGEGQLSPAAIGKVESSLVRSAFMRMVLKLNEAAFRPLFMRMFDWAVLDLVDDADEDAAAADGVVARQVVLFKTFNALSETLRSLVSSYYSTLLDQVVELLSGWSKLSRSPAAGSVQAELWVHVVRSIQLSATHDEGVFWNPTRVARIATPLLDQMNLLAGAGAFIDEADFVTTLGGVITALLTNVNDEPTLKLFNAKLLQRASGTRATNSTRVRSTATQLLAHMWAAQKDHLLPLVPETIAQLSELLEDDNDDIVGHANQFRVHIEAALGESLGSYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEJ8</accession>
    <name>W3VEJ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEJ8"/>
    <dbReference type="HOGENOM" id="CLU_085418_0_0_1"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04646">
        <property type="entry name" value="LbH_Dynactin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="283" mass="30225" checksum="1EBFE09B4470BB3C" modified="2014-03-19" version="1">MSLLRALQSSGILTDQHSHPPAPRGTVRLVPQALTSDFSLSPSDRTSVEPCAISPSPCRRDNLIVGTRVIIAQDADLRGEISVGSGTVIHPKATILALQAPISIGSDCIIEETAVIVNRTSNPIKIGDANLFEVGCRIEAASIGSYNVFEPRSKVAHNVAIGSNCVVGAGCTLLPRPITDDQLASLFDDEDDAAKSAVGSTSEQNREADTNDGQERVFETLPDRTVVYGSDSRRRVWSGEGAHQQAALHAKHLEYLRDTIPRTHKLKIIQGVRAPPPTNTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEU2</accession>
    <name>W3VEU2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEU2"/>
    <dbReference type="HOGENOM" id="CLU_008149_0_0_1"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="798" mass="83739" checksum="5409556647AF19DC" modified="2014-03-19" version="1">MSALRTTSAHAAAASAAANPEPERSPRRKMSTDLMRIKNFPSSLSLRKPADPNTPPRSDPAASTGTGTGTGTFSRLRALGQSQASDGKSSRRTSRLFDAFKSSKKPPPSFEVVRKPPNRSTTSFHSSLQSSTQDAVYRSQSRLSTQDSPQVLEAPPRISLSAPTPDPSMPSFAPPTSPSVPNNLGSRPQYPPSTTRTRRLSSNLAAATTNNTRRTSDPHTISRTHSPAPSTNLDAATSGTFSLHSFRNVRSASDVSHADDPSASAPSAGAHSRVHSIISVDEYVTPGEELPEPRFLDEHTSRAKSPDINRAQSTSPVANAKPASISAAKFRQAARQRSESGTIPTLDNIHAGRPPRSRTPSQDLAAMEAVLAQTNQRSVRPADPDRRRSTGPTSVSSPVLASAAEDNHQRRKRGFFIVLSAVRVAAAGTLSGLFGGSNSALDQQNGAGSGDRGVVEDGPSPANGLRGQGFDSARLLGKHVDANGRRRTLIDVIGEIENAPAPAWPEHRRSVSAAAEAPADGVAGGSVMAPPRVRRSTDQGRGGQLAPDAAARAASLSVQPAKPGTSSPALSADQGLPSPTSPSGVWPALRTASPGMTSSSRSSMASPVARPASASPAERGAEGQLSAQQLSQLNVQQGQAEMHEQYMRNYMAMMANPMLAHQAHVMAMHRQQQQHYYGRAASVGGSHLGAGANGNSVQGGAPLAAFMQPGVPNAGGTRERRAHSRTPSTSELDAAAQMASFAPYAYPMYAQQAFYPPGFAGWGGGYARPGYATTRSEIATPSSARLRSQKSDQALRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEV3</accession>
    <name>W3VEV3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEV3"/>
    <dbReference type="HOGENOM" id="CLU_434196_0_0_1"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="630" mass="65832" checksum="CCD5E1FA5E732CB6" modified="2014-03-19" version="1">MSQSTPTAVTKRKVMGRMDTAPAESPSSSVTPNARPRIIRAQHGYSSPSLSNTTTPTASRPIAGTGRARVDMSAFASPAQSSPAMSPSTSRPMSASSAASANITARLSAPSPAVRAHTPLHAKSSSSTVGVTASSYKLQEARIDPPVDPNLASLRSPRIRTRNGSVDLSASPSVASPSLRPPPASQSMASIPRAEQLQFQKPLATAASPRPAPALPTRQLLSPQRQQAPAEQAALRATIRSPSPTQTAASAPSIGRASSLQNTTQPHTQLSSGRQTPSIASAQASAGGGTAPGRPVSDSTSSTPADDLPAPPLSAGERWPDSASGGYFRPDQTPAASNWRASLRSGSTSQRAAIPSAFADLADGLRSPRRSEDARSSFASSSHSALMASLPLSPTSDTPRSPSEAGEAEEARIHRKLLDLEITNKSLLAINSALEVTKLKQAKEIRELKRRLREGRSLSFGAVSRDSVGSGVFSDDDALESESDEDAGEFIMAREDPELEAAHQRCKDLVDGMVEQARRAILAEYEAPENTGGKVLHPAEIEEMQRVAEEGDETGADTTFATDLLETSITFDHSSGDTSREDLPASSSLQLPNGVHLPTAATSSNLSDDAVDHVLKQSSPYASGGDVSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFI7</accession>
    <name>W3VFI7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C-4 methylsterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFI7"/>
    <dbReference type="HOGENOM" id="CLU_047036_1_2_1"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="229"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="400" mass="44228" checksum="9430DF8E809440C5" modified="2014-03-19" version="1">MAATATATTAIDNIPSRSMPEAVAGTKRRAAATTATAAAPATSDSDFAHANRSSKLPKDLAGKPIPRSKHWGYDLTLLQPRAFVWKNLVNIVLIGGFTLFNSSAFGHAVYDDLTTRFGSFNLRFFGTWIITTSVLWGLSALYALADLTGRPKWLYKYKVQPFVRVKGTEYANIALGALRNLVVVATPLMLVGAWTIPTPTSSDQLPGPLRTVATVLFDAIFFALALRVATVLCTEIGFFHVHRWFHSPAMYARFHKKHHEYTAPVALAATYCTMTEHLFSNLLPNVIGALIVPHHWSQYVFAFTFLEIGTIQAHSGYYIPGFNSPLQHDFHHFAFTENFGPIGLMDTVYGTNLRYRKTLAEAKQNNNGSEVSARLEVLTFLAQREVEESEALEAQNKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFJ3</accession>
    <name>W3VFJ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate carboxypeptidase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFJ3"/>
    <dbReference type="HOGENOM" id="CLU_005688_2_0_1"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="280"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="470"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="722"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="93279" checksum="21498BCFB403ABB0" modified="2014-03-19" version="1">MAPFQHFDTEALASTPLMLDNDYADEKAAPSHSKPASPIQVNIRVPPIGKTYSFRGFRALIALVLLLAVPFFVVKSTAEFVSDALIRLTRPCPHAASSVRGYAEHLRSVGFFSAEANADSLQRPDPEQRWRQWFDKLENDFLAVPSADSARDALKRYTNVTHYAGSEGDYNSALQILEEWGTLVGAPLTDDLKHLVFDAGSPQSQAYLRGEGDKNGVRAWTDTYAVWLNYPVNSSLTLAKPDALDAPYWSAKLQEDVLEKDPTSSRGVPFFHGYSASGSVSGQVVFAGMGRKQDFADLAARGIDVKGKIVLVDYGSNFRGLKVRAAQEAGAVGVIIYTDTIEDGEVTEANGYKAYPDGPARNPSAIQRGSVQGLSFYPGDPSTPGKPSYRNATRLEPQDADSLPKIPSLPLSYTEAKVLLAAMKGKGIRASDVNDRLAGAIDGVEYWTGPSDDVVHLENFVDLQVRDIWNTYAVLPGHITDEVVVLGNHRDAWTFGAADPNSGTAAFHEAIKGLGQLYRSGWKPMRTIVFASWDAEEYGLVGSTEFGEDYAKWIQDHVVAYHNVDVSVSGSVIQSSSSPSLSRFVQDAAAKVDDPNTSGKIKLDAFNPLGSGSDYTVFLQHLGVASTDLGYKRAAKDSVYMYHSNYDSFFWMDNFGDPGFRRHEAAAKIVGLMAIETSTQLFAPINVADYAHELTKYLANIEKLAAKELGIPLGARHPAWLGELRIAIHSLGVAAKGFEKNKAFLRKRLVHLAKKVHKQGGHDKEIRKVLAQIRRVNQKLQTFEQGFISNDGLKGRAWYKHLGTAPGRWLGYGATTFPGVTEAITLDKGSGLQAEAHRLTTHIKRLSHHLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFT0</accession>
    <name>W3VFT0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFT0"/>
    <dbReference type="HOGENOM" id="CLU_435580_0_0_1"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="614" mass="66986" checksum="1B8A3E4240EFEC17" modified="2014-03-19" version="1">MSDHEAAEAAPIAAAPAASEEQVASPGSEVAAPQAPKAPADNLEDALFGDDDEDEEEQVKPASRSSAPKDDDATQITANGADDDDDEDDEDEGIRRNVRRSRQQRVASASASPPPAGANGLAAPPPLDPSSPARRSDRSSRSGSPYGRDGSQDMDDAALRQLEYKEDEDEELQPDDNIEVAQLALPQLPVRHTKEHWLARIPHFLRYVTTPFEPDSWDEEQEEDMLRDEGFNSGFAHDEGATSLLRTSNTIRWRYTDELDQDGARVPESNARIVRWSDGTMSLQVGSELFDITQQTEKGRVSVANTGANTPQLGASSQSAGPSSSQQLLSQATQSVPMGSSGSTNRPAQSLSYLVVPHEAEQVMEAQGPIAGSLAFTPADTQSETHRRIAKALRFQKTARVVATAAGEGALDPEIEKARIEKELKDAEKKRVRERQKADRKSGKFDDDMFDIESRRRSRYVGGRKLGAGPRNADYYSDDSDLGGGADDVGGRGGSKRAAASQRYAEDDDDGFIVDDEGDDDDDDGQRAGRRKKKRSSDDEDGMEVDDEPDEMELAEQKIEEAERARKRAAAGESKDKPRRPEPSFSSDEDDQDNDDAANQAIVKKKRIVESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFU9</accession>
    <name>W3VFU9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264023_0_0_1"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1249"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1286"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1382" mass="148894" checksum="BF2E901B3DBAA06C" modified="2014-03-19" version="1">MSPSALSWAAMLNARHFAGLCGGPSIVVVANNELDRPFPFPFITSLLPSLSVRRASIDSASHPLLRPSHHQPGSSFTARRLSRRSASPRNSDEAVGPDTAPPRFPSTDAASIMPSSDMMAAAETLASVASAGPSTPAHEAPSSSRSQPRNSTASSSANTSEPKKRTRPVSACEACRAKKVRCLLSPDAPVCQNCLASGKQCLFRVDDLAPALRAARFAHCGPPSANARTIASKKGNKSAARKSIDDSDDAAARPKPAKRKKSTEDSESPIPKEKDAAHQSSPAAAAQAAASSSSATAKHKAKAVFRSFANPTNLAAPLPVPITNTPLQPTTSASSSSNIMASPSRTSHPNIARMHSSSSSRRRSETISTQNDFFDRDFASSAGPSTSSAMAYQKQRFDHPSMVRAPIDPFAQSHDASYYGHPVEVAAAPGVSPASGAPSVFLQHQSPSDGSVFSNRSGRSATMFAAPKPLHPPSVDQHTSRRKLSAPASQSRRPPSRPIDPMSLEYYGHPSDSASVHKFEDPDRPLVDRNMPYNESGSPARGVSAELRDGIERWQRSGASRPGDEHDESAVQEIPVAQPRPKIVLPFFRWFGTTANTPGYRKIKVGVLQDSEVPGTDELAPALEANQASDNPPNFGFTIRDDDDNTAATPAKPLDDSVLSPHPARTASPGAHRFENKASSSVTRELFEINRPRYPRKDILEHLVSLFLTHFKSSWCPWMEDDELKNGVDNGSMPAILANAVCAVAARFSNRPELRKVPRKSSGDPFSEMAKILIIPLLSFPSIEVIEALILLSYAEFAAGSDSGLWMYVGMALRMAQDLGLQHEVSIQSIPNEKHQEKARLLFWAVIALDRITTFGTGRPVSIRENEIDIELPKLTESSDMKDETVVFGHVVRILMLRGRMGELLNRRERDDSSISAETTKRDLTRMWFELAQSYSDLPANLHFNVQTFQKSATHNQSPGFVYLHVLFQSTIGLLDRPALMKKFTGDSVPLLPSFAPAASAAASRTIADILTLGDAFDDRCITASPYLDQLVLPAGRSFVAEREAAREALRNMGHGTTPAPSRPPSRGGPAQQQQQQSRTSALVSTKSYAEINLGACQRILQKLQQYWAGASWPLRALEQEAAGNGSEVDPQASDEDAQSAPIRDIEMVLKWAKSRIRSKKRLARSLHATPKADAMALDSIDGVNGILAANTTGSDEFASTHSGDSPFGLGISAGLTFDIDALMGSWQMDQFDPVASFHAPISMAQFEATPAHAQQEQHEHQQQQPQPYGEGGGYVYGGEAGGRRTSMSGQTGQHLHPSAAGGVMVSPSRASHARTGSMGTALTPYAHPPTPGQLDTSSFAVAEFFSHDQSVWPLAIQNDDFDQEAVNLIASAMQLPSYPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFW6</accession>
    <name>W3VFW6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000036">
        <property type="protein sequence ID" value="ETS60449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFW6"/>
    <dbReference type="HOGENOM" id="CLU_994419_0_0_1"/>
    <dbReference type="OrthoDB" id="2556201at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="280" mass="29345" checksum="EFFF2EA63F6AC649" modified="2014-03-19" version="1">MVGCRGRARNKFSQQTPARASSSRVAPISNLVSTAGGSSSRRRNALADATNFASHFGANILDVEAQVACHDKPNFSPQVLRSSELAFGNFVQHLAVRELQRQGLSDLGPEQVATAADAIQTQIQSRELSEPLATIVNDRDIWVSYLHIYAMTGRGQINNITIEHTSIRNRYPSAAAAAADDDDHGEVDGTDEPVSGHVADAVQPPASFDSMDASASSVAVAAADDLPQTPAAAAAASTVPSLAIDPRLLDEPSASDGNRLEASPAPESIDPSGPLEEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG77</accession>
    <name>W3VG77_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG77"/>
    <dbReference type="HOGENOM" id="CLU_024138_1_0_1"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="82"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="347"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="557" mass="61399" checksum="179C69271AB440D9" modified="2014-03-19" version="1">MKRTTDSAAAPLPKRPNTEAAPQSIADVDIPDASTTMSSTTAAAAAAAEPKDFFKPIGEHVADGDQPASTEVEQKMVDEIESLCMDCHKQGTTRMLLTYIPYFREVIVVSFSCPHCGNRNSEIQSAGQIQTKGCLYTVHVTNPTDLNRQVVKSEHCTITIPELQIEIPPKKGQLTTIEGVVSDTLRDLELDQPLRKHMQPEAYAKIEEVCDKLRNILGEEKADEEAAANDESNTSGLRSLGPVGGSTNTMSAEAKAERKVPPFSIRLDDPSGNSFVEFMGDVQGRGMSDAKWSKRDYPRSKEQNELLGLSGTSSAPAVEGEELHTTGFDKDAGETEFDNEEVYTFAGTCSSCNAPLDTRMKKVNIPYFKDILIMSTNCDNCGYKDNEVKSGSAISELGRKLTLRVEDKEDLSRDVLKSETAGFAIPEIDLHLAPGTLGGRFTTLEGLLQQVYDELSERVLMRGDSSQNAENFEGFLARLKKVIACDEPYTVVLDDPLANSYIQNPYAPDVDEQLTDEKYTRSWDQNEDLGLNDINVDNYSTDPELQQQQPQQQQPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGA5</accession>
    <name>W3VGA5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Membrane fraction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGA5"/>
    <dbReference type="HOGENOM" id="CLU_038957_0_1_1"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="43153" checksum="BA90CA254F24CCBF" modified="2014-03-19" version="1">MACSSSNTNAACANCACGAKAGGPSQASAVKLASRNKSESTPLLWSTTTTTTTADASDATHANYQATAPAVASSSASTLSASHDCPSSANQPHDPSFVCCRDVVAADERTLIDPDFARDCIVGLSDGLTVPFALTAGLSSTGSTKLVVLAGLAELVSGAISMGIGGFLSAQAELSHFAFNLNATQQRVERSCQSEVQRQVHDILKRYGIATHTSAQIAAELTAKEHARKHAQQIARAQSLHASSAARRKIFGCIPLPGSSSSSPPSSASSLPIQKRVASDEESQQPLVHSDDGDDDDDLDQAGLTPFLLKLGDGLEPVSTSRLYVSALTIGLSYFFGGIIPLLPYMFVEQASRALLLSVIITGVILLIFGVVKQRVTGGEGGVKGYAYGALSTLAVGGVAAGASWLIVGLLEGGSDAGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGC3</accession>
    <name>W3VGC3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGC3"/>
    <dbReference type="HOGENOM" id="CLU_060766_0_0_1"/>
    <dbReference type="OrthoDB" id="2556037at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="324" mass="33269" checksum="EC51BD9793572B31" modified="2014-03-19" version="1">MSVSVVPNDAAPLSSSAAEVTSAAPTHVDAATFAAVEQATGLDAHPPPSRQAVTGLTPEQVLQELRNSGYIDQLRRQMIEAFNAAGPASARPPNAAPPSAAVQPASADPSKSDSTQPASISAVQAESASAPTISASTATALSSMPAPSAAFPPSAPKAGMELGSKAAFLATLAEPLKQQVEKEHDRLRFLAPREQQDKLLQLLESEPVAHPQRESHGEASLFDLLVRHIVAGAAEPDATAGVLSPDGRLGKQAAGRIAETIAELLHPASKDADEADDDEEDADDDGDDEEDAEQIRLLTSRPPGPTSPAAATSDPTPQPAHGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGM0</accession>
    <name>W3VGM0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGM0"/>
    <dbReference type="HOGENOM" id="CLU_010191_0_0_1"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="670"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="761"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="942" mass="101879" checksum="C54ED2A7BA564281" modified="2014-03-19" version="1">MSYPPERHHTDVPPSYHDHPSASTLHDHQTGSARDMRERSPTLEPWLGLRARLILSPISVAMIAVLFVGARVLMSASDVTNSVASTKTKLLAACDAVEDRASLAASLPSLTAATVNAQIAQSIEATVHGAARVFDLSLTAIEKTLAYMVNSYRSLLLCFMELLVRGALAVLISAVQLISQAVNAAAQGIRAAIQESVQGVNAVLATAVQGINDVVGVFGQHLNAPSIAVPSLAALQNVELPHEIQDGLAKLNETLPTLQQLRQTMNQLIQTPFEQMRKDVNATIAGFSFNHTMLPVPQMQNLSFCQKIDTSPIDRLGHELAVAARWAMAMLAVVALAVVLVSAAREWCAWHKEQQGIKRTTALWHTQQQHSYTEKDDRQSSGKELGEDDVRRLVSISRSPLAHSLISGASRRLGVRSRWAQDRLLWLGALLSHPAALACLFTGLLGLLCVWVQTLLIRRITHRYTSELDDTLTHLSSQVLGLVESSARNASVAFATTANALITEVSDELNTHVFRWVDTTTLTMNATLNQFVDGITDTLTTTFGGTPFNAPLQTFVQCILGQKVAGIEKALTWIHNNAHVEFSLVPDDVFVPSALQKDVVLHPIRSALVGDGTDGSGLAGQVVGKYLHHLEQEKVLFAVLTAVWVVVAVGGILVVVYATIADGWHVQKGEGDAAGGDAEKPRGPTSTGPGWLRFPTRSQRSNRTASDEGQQMQVAVVADAGRSVRGGSIVDSARMAGRGHIAKDSISYPFQIHHSLSTAVQSSSPRFANSPISAQDAASPPYHRDAIDTPTPRERSSWLSFLIARSTAESSQPCRADPVAETAQDRFERLFGCSPASSPTSPGFQELRDAPPVEGPRHRQTLDLLPAQGWIGSKSPVPQPGNRGAEEQGFGSRDETVELVRASRGVEVEVAEADSYPHEARRAELVRQQRQPSAQSMSFYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGM2</accession>
    <name>W3VGM2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="9">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA4</name>
        <name evidence="14" type="ORF">PaG_06198</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002681_0_0_1"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000795">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1656"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="1165"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="829"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1327"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1418"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="845"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="907"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1424"/>
            <end position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS59876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1698" mass="181982" checksum="0E6B600AA0892371" modified="2014-03-19" version="1">MSGGAPPGSGTSAQPEQSPSSSGSMPASNSLLDMLAGAPARVVTSPPTSSFTFSFPAPSRSASVSSATTITGTSPTPTTTSVPTDAAVADSPATMPGSSRKQPQDVSQLMQQFMAPASPLVILSPNAKSSESNDPIPSASPTKQPSAKPQPAIQNKALQLPPSPPSSVSSASGPKLRQPSSGFDSPATSSPPRQNAQLPPMDKDTQTPSAPAPAPAPAASPSVKTPFDFVSPFDMLSSNDNQSADTTPQPSEAQKNSSDAAAKEPLAASVAGYEAAEAGFARILEKLSASAAQSKQASQRPEASRPAPEQPKQEEEPAPAATSSKSPTRPAFRKLPSVPAQLDTPDKHFHASRHAAVLKQDDAFDQPKSSGLSVLSPSRSSSAPSIATLDLSAQQPGGLSSLTNTKVESSGVALVSSPFHFPCNVSAAGLLPASRIAILGHNVACYAMNKGKVRLIHVASGARLLVQAPGKAAIRSIAAFASSDDDDTFLLAALTERSKEAADEGVVFWQIPASFVVDGKDQDSPLLMGRITADPYKSPFIYRFTAIAWHPAQPRIAISTSDSNVMVVDIVQQLLHQTQPASPSKKLRSLSELDVDPDSKDVAHNEPLCGFAFTPDGAMLATISAPLEGDVSWILGFMPLDRTAGQAKEGDHTFLIKSPLQEPMIISHLSFITDKQQHIRAALVGFRCNTILGLYDMDSRAWKHVFKFDGPLHDGDKEHFNLVQFDAHNSTLLVCNSYRSSIFAVPLDFQPLPEFDANTSTKTELEARLDQGLLPWGIQLSYPIKEFALQDPCTSVSISPDAEAGKPSRLFVVFPEGISILRLLVVEPPKDEPAAESEPAAEPKPQAKEPEAQPEEEAHAPEPEVVSAPAEVATTPSKSSKKKKKRSKVNAAQAEVPTSEPQPEVATEDHAHPVEPVREAKDVPAPSAADAVQPTQPPRSAQQPAPVADPVESRPSVSASHIDATLSDTVTVAVHDAVAASVGDGFRHSIESAIPKEVERLISSTELKAELTRNIAQTILPAVQRTAMEVVNRVLAPHFEDVMMQVSERAERTIVSEMTSVRKSLVAEQSESLRDTEKTMQAMHARMEEMHERIKEMHARPQPAGRFVELDESDPASEVEKERRFVPAPVPAQSDAGAVISTETASSGAVVPARIQSKCKLPERVAIIGAGPVGCLAALAFAQRGCKVDVFESRPDPRTDEAVARASQRSINLALSTRGISGLRSVSLVGLGKYTSDGTDLADLVLQESVPMRARMIHVVTRRASAGCKAEVREQSQLYSTKGECINSVDRGRLNNILLDHALMHPNVHVHFEHKLQSVDFDHDSRTAAKKARAGQKQASGKSETRASERVKLEFDVHTANERASRRSVVHLASFVLGCDGAHSSIRSAMGSLSRMHYTHNYIDTGYVELSIPPRTSLGAGSRARGDGGLDGKPGGHDAFELDPNHLHIWPRHSFMLIALPNQDGSFTCTLFAPFKMFSKELATREGIVAFFDEHFPDALPLIGADKLVAALTSRRASALGSVQCDPYHYKDRAVLIGDAAHAMLPFYGQGLNCGFEDVRVLFEMIDSSQGLEGALEEYTHTRHPDLVAIRQLAENNYREMAHSVVSWPYLLRKKVDSLLMAVLPTSMWSSLYAMTTFSDLPYAQVIRTEQRQQRILGHAVASGVLAVLTGAALGVYRTRGVWQPLTRRWIDAVNTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGT9</accession>
    <name>W3VGT9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGT9"/>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_1"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="39"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="469" mass="51057" checksum="AE4D580987E6DE48" modified="2014-03-19" version="1">MAAAVASNGDVQQITKDLQAVSIDYDNLNPLSPEVIAKQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELVRNITIKLGYANAKIYKCERDECPRPQCYRSYPSDKEPHPDCEVPGCGAKMNLLRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAVEIMKLQHIIILQNKVDLIREQAAEEHWKSIINFVKGTVADGAPIVPISAQLKYNIDAVNEYIVKRVPVPTRDFTSPPRLIVIRSFDVNKPGAEVEELRGGVAGGSILSGVLKIGQEIEVRPGIVTKDNEGKIHCKPIFSRVESLLAEHNDLQFAVPGGLIGVGTKIDPTLCRADRLVGQVLGAVGQLPAIYTELEINYFLLRRLLGVKSDDKKQTKVQKLAKNEVLMVNIGSTSTGGRVMSVKADLAKIFLTSPACTEVGEKIALSRRIDKHWRLVGWGTVRRGTTLEPENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGX7</accession>
    <name>W3VGX7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_04673</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGX7"/>
    <dbReference type="HOGENOM" id="CLU_032441_0_0_1"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000904">
        <property type="entry name" value="Probable SEC13-protein transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 18" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS60765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="349" mass="36978" checksum="87D30E783959CB36" modified="2014-03-19" version="1">MATLTSSSAALALSAERPKNVETQHEDMVHDAQLDFYGKRLATCSSDRTVKVFDIVNGSPSINAETLHGHQGPVWQVAWAHPTFGDILASCSYDGKVIIWKDNGAAAAPTQSGPYGAQSAYGAPASTAGGWTKIKEHTLHTASVNSISWAPHELGSILACASSDGNVSVLTFNNDGTWAVDLVSAHPVGCNAVSWAPAVVPGSLISAQSGDAKLVKRFASAGCDNVVKIWQFSDEANRFVEADALQGHTDWVRDVAFAPNVGLPRSYLATASQDRTVHIWTQDAPDAAWTKTALNPTAAQGAGKFPDTVWRVSWSVSGNVLAVSCGDGKITLWKENLKGAWECVSEMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGZ5</accession>
    <name>W3VGZ5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGZ5"/>
    <dbReference type="MEROPS" id="M16.A09"/>
    <dbReference type="HOGENOM" id="CLU_004639_1_2_1"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="155"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="317"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="9">
        <location>
            <begin position="501"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="10">
        <location>
            <begin position="895"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1209" mass="135128" checksum="BDEE811F72D8BBE5" modified="2014-03-19" version="1">MLPVRRSLLRTASRNSSASQRTLSSLAIASPRLTVSTAANLLRSPNTPNASRHLSSTVLPSLPAARTATAPSMVASSSIHRAPGSSRQLATPASAAITLGTGSFEGLPAGFEIQETLNGSKAPTPYAVFTKDLEVSAQDDMRYRLVRLANGLEALVIQDPKTDKSSAAMDIRVGHLSDPEELQGLAHFCEHLLFMGTKKYPRENEYSEYLSNHSGGSNAYTGMDNTNYFFDVSPDHFEGALDRFAQFFLEPLFDPSCSEREIKAVDSEHKKNLQSDMWRGFQLDKSLSDPTHPYSHFGTGNYQTLWEEPKSKGMDVRDELLKFHDKYYSANVMKLVVLGREDLDKLTGWVIEKFSGVRNTGREPPLFDRSPLTQEQLQKQIFAKSVRDVRKLKIAFPIPDQGPHFRSKPGSFLSHFIGHEGEGSILSHLKKKGWCDRLSAGATGDANGFEFFKISIDLTQEGLKNHEKVLESVFKYIHLLRTSNLEQWTHDEVAQLGELMFRFKEKIDPADYASSTATQMQMPYPREWVLSGAWLTRDFDRDLIKQTLDQLTPNNCRVVVMAKTLPDGSIEWESKEKWYGTEYSIKPLPQQLLTQAPTEFEDLRLPSPNSFIPADFEFKGPLADVQGKKPTPRPQLVVDNDSMRVWHKLDDRFGLPKANVFLVLRNPLINATPSTSVKTRMFVELISDSLVEYSYDASLAGLSYMLDTQDQSLALSLAGYNDKIPVLARSILEKLANFQIDPRRFELVKDRVKRSYENFAIEEPYRHAGFYTTYLLHEKMWTPQEKLRELEELSVGAVQQFLPELLQRMHLEMLVHGNLAKAEAVELANMAWNTVKARAVNKSELVSSRSLLLPEGCNRIMKVEATNAANVNSAIEYYVQVGEPTNVQLRAVLSLFEQMATEPVFDQLRTKEQLGYLVFSAMRRSVGGMGWRIILQSERDAPYLESRIDAFLDQFKATLDKMSESEFEGHRRSLIHRRLETVKNLYEESQRFWAHIFGGTYDFASRYADVEAIAKVSKQDVVELFMKYIHPSSKTRSKLSVQLNATAKPSARFSAQAVDALEQAVASQGLTVPKEAWEALRAQQPAIESVKDMASEAMAQNPTPVPAEAVKQMLGLVDSLSAQFPFVEEKAEVATSTVASAVPAVEVKDAVAFKASLNPSKAAMPVVSFDQHAKDPSGEGDEVARIAEAVLKATAAPAAVEDGEPKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH04</accession>
    <name>W3VH04_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH04"/>
    <dbReference type="HOGENOM" id="CLU_022000_4_0_1"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="49"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="175"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="281" mass="31445" checksum="C66479302273F8B2" modified="2014-03-19" version="1">MTASTSTRAALSAADSQWLFTPSDLLLTPSVLGGLDPAEEKHRRCKGVHAIYRMGEYLRLSQHVMNTACIYLHRFFMRKSLQNGNAGYSHYEVAAACVFLACKVEESHRKLPSIIDAAMASFDKSPAGQQRWMERSFRADPASKEFGRWRDTILVNEEELLETLCFDLIVEHPHEILVKACSRLGVDTWLVRLAWTTLNDSLRDSICVTFEAPVLAAGAFYRACTVSQVEPTKFSAKWKGKEGDEAQLAWTDVFDVDEDEAAEAARAIGSDVYASHEQHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH39</accession>
    <name>W3VH39_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH39"/>
    <dbReference type="HOGENOM" id="CLU_1687442_0_0_1"/>
    <dbReference type="OrthoDB" id="10470808at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="156" mass="16835" checksum="1AC846A5E3CBD730" modified="2014-03-19" version="1">MGAPRQRASVCARRGGAEWSGLLELALLAVMTVTVAKAMVVIAEQQQQQQLKRAIAPNESRESCRSGTAALQRRALRFAAGCRRGALHIRIPNPNPSRQAAESAPPMIGLVIGGHGCLQILHHSAFLSSRHSPSPLHCRRWPFHAATHTTPVETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH92</accession>
    <name>W3VH92_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH92"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_3_1"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF7">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE (AFU_ORTHOLOGUE AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30411" checksum="65E86393BDFA9C04" modified="2014-03-19" version="1">MSAHAAIKAGNLAVISGGASGIGLAAAKYYLSQGMKVAIGDRSEASVQSASQELAQKGESYVGLLDVSDQTSVSLFRRSVFEKFGGANLTVLMANAGVGGPTKASTSEGWDRILSTNFHGVVNVCQAFLPDLKKHGQDALIINTGSKQGITTPPGTGPAYNISKAAVKVFTESLAHELREDKASKVDVKLLIPGWVHTGLTGAKDGKPKPDGAWTPEQTVAFMVQRIQAGSFYILCPDNETPRETDLARMEWNVNDVIQDRPALSRWHADYTEQFNDFIKNKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH99</accession>
    <name>W3VH99_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH99"/>
    <dbReference type="HOGENOM" id="CLU_041583_3_0_1"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="370" mass="40046" checksum="62C9F33C9ABA5508" modified="2014-03-19" version="1">MSRTKGKKPTQHQKAEPAAAVDVAVDAAVDAADSGDVQVAGAKKGKLIRPRGKRGGVKHRKGGAAQNTAVQKAALKESRKAKTNAGADQDGGASVDGSAAPVPPAEHAEKIAKFHTLLKQLEQATTAEEKDQIQSGLDSLGGLAQYQAWSLTGSAKAGQTPTSKWCMEALNTVYQHDRNQPKFRVLDVGAITGTAYNKYRWVDATSIDLHPQGENVQKYSFFDFPVPTKDEEKFNMVALSLVINFVGDVRKRGEMLRHVHKYLPTAEGVPGFCFLVLPLSCLTNSRYMNQSHLRAILSSLGFDVLKQSDSAKLSRWLLQAKPLAERMAAAEASENIAASADWDGTAFKKRDINPGTNRNNFAIVVDPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHK7</accession>
    <name>W3VHK7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHK7"/>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="255" mass="29442" checksum="2480ABDF5D5A17CE" modified="2014-03-19" version="1">MGAYKYVEELYKKKQSDVLRFLLRVRLVSDPPRLPPTSAPSIVAALVAASRTRYSAVTEFTASARSAQRQGGSTPRICWEYRQLNVIHRASRPSRLDKAHRLGYKAKQGYVIYRIRVRRGNRKKPVPKGATYGKPVRQGVNHLKYQRSLRATAEERVGRKCSNLRILNSYWINQDGVYKYFEVIAVDPQHKAIRRDPRINWIAKAVHKRRECRGLTATGKRSRGQGKGHRYNKTQGGGKNATIRKRDTLQLRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHL0</accession>
    <name>W3VHL0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHL0"/>
    <dbReference type="HOGENOM" id="CLU_010348_6_1_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014133">
        <property type="entry name" value="Cry_DASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02765">
        <property type="entry name" value="crypto_DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF22">
        <property type="entry name" value="CRYPTOCHROME DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="28"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="639"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="734"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="380"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="420"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="535"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="874" mass="95842" checksum="E7B0FE8AC507F251" modified="2014-03-19" version="1">MEAAASSSSHSGSHRGTATSPGSDSAKSVLICLLRLDLRINDNPLFYYAHQTPKPIVSTAEKTVDLSKLEDEALLGSTADYLLPVFVFDEREMELSGLPGYNRKGPEARTKEYGFWKTGGFRTRFISESVYDVRSRLRAAGSDLLIRFGIPEDVVANLVSAFQADGTHVEGVWLQKEMTYPEIDVENAIVEKLQGTGVPVQFVNGKTLIHPADLPFESSETPDVFTPFRKKVEALGPNMVRPVKPSPAKFKSFPPRVPRTTDYALDVSYEVDVDGLAPRALEPKDKQEGQVSFHDILRFLLTPLNDSQLPPTLEASALLQQRHPASAFPLRGGESSALDRLDWYFVRGKSADSTRWGKADPPPVARYKQTRNNLIGHAYSTKMSPFLAYGSISPRQIWEALDDHEKKFGEDQNTYWVRFELLWRDYFFFVAEKFGDLLYDLGGFERATDPRQAAKKMEEGWWNKWDPLKDGAEHQMTRLLEGRTGIPFIDANILELRESGFMSNRGRQNVASFLSKDLGYDWRIGAEFFQSHLIDYDPTSNYGNWQYVAGVGNDPRASRQFNTIKQAKDYDSHGDYVKMWIPALRNLHADYVHTPWLLTSEERRRYGLKTTKMDVTIDGYPAQPLFEHEGWQRHYERKQGVGSKMHGNPQEKVKDGKVPRRHRPSYRVQAATYGALSDGGQFDQLSASAGTLSGHFDGSASRNVIPPLRGASGSIGPSYIARQSQGFPNVGALSIGAGSERSGSPFGTSPATHTGSMGKFTRASPAASTNLPAPVGRAPGTAFDFGPGRTGSAASVENPNGRLRRGGNGGNGEHALNGYADPTSGSGGNGGAAGAYGNGSVNGVGVGAPTAPNGVAGTQLSKADLETSWRRGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHM8</accession>
    <name>W3VHM8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHM8"/>
    <dbReference type="HOGENOM" id="CLU_000315_4_2_1"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="284"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="675"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="893"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="962"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1097" mass="121154" checksum="7F82018BF8CB98E3" modified="2014-03-19" version="1">MVRNGLLSSAASWTELQHNDSDDDFLDDQYQHAIPSTTRKRRRIQPERSNAAPPKATLRALLGLTKADDYIETANPPFDAEPSEKDVLDRGVTHTANLNALDQSRSSASDSDSSSSDEEEVILPIKRIVRNFPSFVSRQDAPAGTVIAPPEKFPHVGETLLSEPEEDEEQALSISTGGSASLPHYPVGKSDPVGDESESSQSDDEVALAVKPKALANQKSASKASATHGSIAPAAFLEGQKPSFPVPKELRDVGPLVLGPGIQVPAAINRFLRSYQRDGVRFLYRSYAQNRGALLGDDMGLGKTIQVIAFLSAIMLKTGGENDENRRIEAVRSDRQRAGYHCANAVWPTCLIICPSSVIDNWRHELDTWGYFEHAAFSGVRAKEGALESFRRGRLDILVTSHETASLSIEQLRDLDFSCVLIDEAHKLKNPASQMTQAMQTFLCKVRFALTGTAIQNSYRELYTLADWTNPGLLGTVKEWITEIEDPLKHGQKRGADPERIADARTRAEKLVQNVLPIFFLRRTKALIADQLPRKFDKIVFCPLTPTQLEVYRRILAEPEVDLMKHHADPCPCGRIDPDTGLAYRRQNCCFKRDGAGGAWNKNMLKYVYLLQKCSNHVALVFPDPEDLSSHDPDRMDRYERQLSYVQLMFPDSWQLKRCNATNGMDPELCGKWKVLARLLQQWHADGDKVLLFSTNLRLLQFIEFFLAREGHSFVRLDGSTPQPRRQQLVDQFNRDGSIFVFLISTTAGGTGLNLTAANRVVVFDPHWNPSHDLQAMDRAYRFGQTRDVFVYRLIGAGSLEEVVYGRQLYKQQQMEIGYNATKERRYFEGVAGDQGSLGELFGCKNLFTLHESSLAMKSIIDECNISEVTYALAQYLKTGSLDDQVSADAALVERAHSPKSSPPESAQRQEPGGATMALPTATDTDPIRGILEGSGISYSHDHAALVGNSVAEAALYREGKVRKTRQASAVSKSKRATGSRAGEAALTSTSVWPPVRSAPASGSGAARSQEESQSIAAAAAERGLLQASQGGGASRLPDLSDLARLQNVSEVEMAAAVNAMSATEQKSFFDTALQRWNRKQDALAKGSRRQMQQRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHS4</accession>
    <name>W3VHS4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHS4"/>
    <dbReference type="HOGENOM" id="CLU_1496858_0_0_1"/>
    <dbReference type="OrthoDB" id="10459564at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="180" mass="19217" checksum="536CD7DC0D9325C9" modified="2014-03-19" version="1">MIFKTSVASGEASSRSCQVSIRAGGCVVRQGGARPLAAALLRSASVALLIRHKPKTLLHIAFLDQHMSEAAGWARQACLCIATPAIDRLASDVEGSGLGAHRARHTRNTPQCCGASVQRRSASVEARAETQRVTGSFQLSRNLHEPASALRQESAPILASRKFLKPSDPRKDAKPSRISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIE2</accession>
    <name>W3VIE2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ketol-acid reductoisomerase (NADP(+))</fullName>
            <ecNumber evidence="6">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_05442</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIE2"/>
    <dbReference type="HOGENOM" id="CLU_033821_1_2_1"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="18">
        <location>
            <begin position="63"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="19">
        <location>
            <begin position="254"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS60587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="406" mass="44464" checksum="6BF42AB68B8FCC46" modified="2014-03-19" version="1">MNANVARTALRAASRSSSRRVAGAARSLSIAATARPALNKLASAAATPALARGLKTIEFSEGIPEKVYEREDWPLEKLQDYFKNETFAILGYGSQGHGQGLNLRDNGLNVIVGVRKDGASWKEAIEDGWQPGKNLFPIEEAAEKATIAMLLLSDAACTSVYNSIKDKMPNTHTLYFSHGFQVTYKNETGFEAPSDKDIILCAPKGSGRTVRSLFLESRGINGSIAVYQDVSGKALEKVSAMGVAVGCGYLYETTFEREVYSDLYGERACLMGAIQGLFKAQYDVLRANGHSPSEAFNETCEEALQSLYPLVGANGMDYMYKACSTTARRGALDWAPEFEKANKPVLEALYESVRNGSETRRALEFGNRKTYRQDFDKETDAIAAQEMWKVGHKVRALRPENAAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIJ7</accession>
    <name>W3VIJ7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rpr2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIJ7"/>
    <dbReference type="HOGENOM" id="CLU_040443_0_0_1"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="35541" checksum="4F8463D9BEF4D3D6" modified="2014-03-19" version="1">MAKSNARKAAEAGGPTTKPGAGKGAAGWVVPKTVAHPEHHHTLNHLDQVATFYSVLSSALAGEQGAGMVGLQGEMVRSARTLSRKAVIRLDTSVKRSACPKCSTAWIEGLTLAVRCKTSGPHDHVLKKQCRVCGTSVRIPAPNTIGLPPHTRVLDEPQQEAKASGDGDQGKGEKKQRMSQRQRRHVAVLQRDLLNGSKPSTSARLSRRQRSQLRQARLSRRMEAAPLPAPRKPRSPSKPNTTVDPLSSIQTEAQDADSGLGQPREAGVRVHLPQFNDRVAGTGWDDALVTLSSLPSSTDSQSLDVFTAAARARGDHTLVRAIGKNGSLGPQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIM2</accession>
    <name>W3VIM2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIM2"/>
    <dbReference type="HOGENOM" id="CLU_076228_1_0_1"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="255" mass="28036" checksum="0C36383FDBF61F36" modified="2014-03-19" version="1">MHGAQIRVAEFPLQEEEEQQQHREGGQPSAACFPFTTIQHLTTQHEYPHTFHTMSHAQDPTIADEELATTATAGYKVGEKKSLAEYSQLDAEDESLARWKASLGIGASTGAVDPNAPKLSLHALSLVSSSAPGGSVSINLQQSKEQLAQFKQNPLNVKEGVEYSVKIRFSVGSDILSGLKYVQVVKRAGIKVDKMEEMIGSYGPRAEPYEKTFASSEAPSGMMARGNYSVRSRVVDDDNNVFADWEWAFKIAKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIQ8</accession>
    <name>W3VIQ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIQ8"/>
    <dbReference type="HOGENOM" id="CLU_265108_0_0_1"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="415"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1228" mass="129617" checksum="CCE11CAACA21E234" modified="2014-03-19" version="1">MGNGAPPPGSPRKQEQHLYQSATPLDTRSQLLQPPLPHHDSMSAFQHMLPTIVASKQHQHQQSDMVLDNQPSGLWSSDDYDSMMRSILDATLPSDHFVDLEAPPSLASFSASYAGSFVSGSSDSGASPNSINDLIYGASNFPTPPDSDLGSNPRNLSFSMASQAGTAFSPDGSLDLSNPSYPQSYAGSDTTSPFAHNFAVQGTSSTSPFGLHTVQLPPASIPPNNPNAQPWNPNFLAPATANNLHPPTVSEPYNETTATSVEPMHNATNTVVGTKRGADAPDSDTAVAHAPSSAIASKSSKAALPQPDADSAARKTKKAKSTPAPSESKPSVKVTAVAPAPAHINHMSSKLPHMEVGSNATALAAIQRLKAKRLQESQAAANAASALAAAHGTSQTAASATSADRQQLDPATRQQKKVAHNAIERRYRNNINDRIAALRRAVPALREIRPRKTPSGRRSRKAQQEEDLVDGVPAATKLNKATILGKATDYIKYLKSRELRLTSEVAGLRELVRSLEGGEELLELWEAEMDKVVAEQEALAAAAAAKEDEEAQDEADASLNAGADDDDDDEEVDDDDDEADTGESSYNSASSSSPPSARRRTGSKAGRGRRSGIAATLSSVASSRYMLATFLGISFIGSGAEFALDASASDASEAVARPAPAKLMVGASRQLLKRSAGYVAPSTSIAQDPHAFDSVPSHALAFEVLRIVSFAFLFLFLVWPIFSRFLPKARSSSSVDASASSDDAPSVHSAESSRKLRVSLTKGDISVAAFDSAARSNVSAPLSAPMALPSILGSSLRLVLGRNSRLHRFVPVQHMSSEEAGALCRLLEVETLCEAKAQASSLLRLHTALRLANSQYVRGSSHAASRDPASVRPRLLATLALAFARLGDGVNSAQDFADSLWIEARSCLRAADAESSPTSALLKDDGLTQVESASWLSSVLSLDLDTALDMLASASASSDLRNYEFSAVLGIADVHYCARLSAVWNRLLASVVRASCPPSSMAPSKLVHGFVTLQSKQRLELDVVHDAETRRELHAEITMLARTAPPTACAWQMAQVTLATWSAVLGNLGVARHVASTLRDQPMSAQSELASVAALYAFVDANAAPEPATTPTPRNEVDARAVLLLAWLSFLRMFADARTDVKRVHAATLHVRKLVSAAAPAAALDEASAHELDELDAGLDTITELCTALGRAINRLPSSATSASTAPLKALVDAAAAADDDRDSGIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIU5</accession>
    <name>W3VIU5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIU5"/>
    <dbReference type="HOGENOM" id="CLU_078576_0_0_1"/>
    <dbReference type="OrthoDB" id="2547083at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="308" mass="33184" checksum="90D5F70D4AD8475B" modified="2014-03-19" version="1">MTRPDGADSAVPSSASHATKTAPTSAAVTLPKPCILLSAEQRGALSLRILRHTRSSPLSDSDILAFQSLVNDSFRGPYHDENFGGKLRYPTTRELVDDLNHSDQGGWVFILSTAEGVPVAGAKVTFSGEGMDAGPGIHTLPNPSYIPDDAQDKPVFWLGALGSVAPGTGSMIIAHIKKFLAESYPHGYVLKAFTVAEWGVNPDFAIPQDSPLVTFFQRQAFKVIEYSWKAPGTWDSFYGGCLAAIEGNKDWIRRTSTSAVPLGNVENSIALIAVASIETRALEPKTGCVCENECGRECWYNFDSTNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIV6</accession>
    <name>W3VIV6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIV6"/>
    <dbReference type="HOGENOM" id="CLU_025520_0_0_1"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10207">
        <property type="entry name" value="ASKHA_NBD_Arp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="664" mass="69360" checksum="30C9C5CCD942E5EC" modified="2014-03-19" version="1">MSGTQQPDSSAASDARLRPSAVGSSSQGRKVSFEQLASTSSSRATSSAVAAPGASGSTSSLSAYSGATRRHSLFGTEDRIILDVGSRYSKFGFSGEPRPRAIVPSVSFSQPSTSYLRLDASSATAGLYGAGDSLWDVDFERCADNQLRRGRRALLLAQLTQLLRSAFTQHLMTDPKKRKVLVVENPMLPNAVKDLICEVLFNNLQVPSVSFVPAPLLSVLAVGRITGLVLEVGYLEATLMPIYYGRPLASHVATTARAGRRVNARLRRLLLRYAKFVAAHTGLQDATRSLRERTRDVDPAMLTDERIEQIKAKALFVGSFEPALSDLADVFSVLELDPSHATLDAGVEQEAVSTVRRKYSATSSATPFTFGVTPESIDPTGSASLIQSVQAPAPHTGSALGASAAQSEVGVIAIPGWVRERAAEVLFERGDADEPGLVEMTVAAIGKLPIDLRRVMCENLLVSGGTAMLPGFAHRFRTQLAAAIEAAEQPGGALSVDRHARRIGSTTQISEGTQRGRALSGSVAVLNDPWPETTQAAASKEAGQGQGGTAPAFAANLLPYMGASLAGALKTTSLTAISREAYDEATNPAVPEAKVEAAGGGDKEARAGEGAKASRPGMLGASKRGSFVGVVGGLETGAYGGLAAVSRHLVGIPGTSTSSDDKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIY9</accession>
    <name>W3VIY9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIY9"/>
    <dbReference type="HOGENOM" id="CLU_011783_0_0_1"/>
    <dbReference type="OrthoDB" id="2555742at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1009" mass="106924" checksum="155506ED128C6F2B" modified="2014-03-19" version="1">MSFEAESTLQEQMAGPSRPRFTGWLTMAPEVDPTPAPAAPSAQPTVETNNATASGSSSAQPVASTHGFGYLGQQIKLPQRKKRRATFQVGSPGLSEDEGGSASSSLSSHASSDAPDFDVRASFAPMPVYGKKPNAAPLSSYQGVGDQGQAGTVKQSGLHNRAVADTQAQQSSSDDEADGLSFGGRRWKGKTVHAVELELEALRDERLMSHAPDAAYLASRLEGVRRNLEIEERKPSYVPYDEDVLTDDEEVALAPDASDVVRQLYPFQHPHVGLGDAPPMPHRPVSNASSVSLVEGETPHDLDFGLQFEGSAPIEQASQEIKIHDPDEVAMPPLPAHLAPHSAKQIDPAARAAALDSRIEVRALRRGDLEQVRDLHAFHGDSDRVSHHMASLTLSSCPLSSPVDSTIRGSPSGPMAHLAGGAPRANFEISIVGGIALPRRARLAPSSPELEAQPRARAWPIRRTGLRSGPAVPQRFFFDPFPALRPPLPAPRSWLGPRVLEIAAPRSSAIFRRRRRQGLANPSLAQRCRHRHSTALLTLLLAGESLAASGVDHEPSSPRRVAPVDDRHSRHFPTELSRFADGPAMRLAPATSSDRTSLSPDHGETYTSTASFLLRLLVDDRHVCLVAVAKPIPEPAAPLPAAADLVGLAARRGEEADSLPGSPQSTSPASLSASDDEASTGLKSLQLDAARAAESSDQSSLSSSPGHGGRATTSSLFSAVGPGAGLVPTAPHTRMISPRGRDGRINNTPATSVFSDIFAERGATVHKPVLADLPGPTDMASAPVKKVMSIPPPRGADARAVEAETILGVVSAHLSVVAAPSEDHLWFGGGSGKKAVEDASALVDVHVLTLATAPEERGQGLGAKLLAALHAECMHKARHMAMRMRNPRAVPVVAPLSPRFIDESTLMASMGASGSKSPYLRGVVGCSLAQLRDSKPGGKYLARTFLEVHPSNMHAIALYRAHGFQAPADDTAAVKRGFYRGDTRIATAERTKRGGTDAWILQRFDGPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIZ5</accession>
    <name>W3VIZ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIZ5"/>
    <dbReference type="HOGENOM" id="CLU_475767_0_0_1"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="98"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="624" mass="64457" checksum="1C1DCAABB2D26EDF" modified="2014-03-19" version="1">MPAGGVPSWAVTSSSAAIFGGGSSTASPAPSQPAPSSLPEAQQPASQPSEPQPTTASTPAPYKPKRKQRPVTHCAPLSSVASSSRVPYSIPHVDSAGCEQALRQLIAVQATRAGFDAATASAMHEVEQLTSRFLTSVFAAASHAAELACRDQPSARDLLYALETHGQPVRELRSFHRQQLDRADDRQAAAATARNKAAHHASHPQIHRLDSAGSRSHDDDADMLPSDSDEGSEMDAWSVSSHSDDEHPNRRAAVHARASKRKHDRARILAKKQRRLDKLAATGGADASGPGSGASARDLRALTSGEQAWRRIADHVVPRHLPGMPPRHSWMQTPAYPTNAYGASLGADDEAESVRAKDPLMLVNRKLANARLVEASLRRLIQNTDSAAAVAYAATRTSGEDAASADPAPANTDKEMAASDASGFAVPKAPASGALTLRLKNKISQPSSTLTSPSQPSTPQASRRPSAIAIATHAGTSTPTPLGMAMGWGGEPLMSPLTPVSATLGSSAAAGAMTPYPPTPGGVYGHYFGSNPGAAGAEGGGGYRSRSQSIAAGAGVDPYATAAPDAGTDKLGIRVPGPVNYKNVWYAPGSSIVGGGIGGGPGAAAATAANNHPRSVKRLRKWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ65</accession>
    <name>W3VJ65_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ65"/>
    <dbReference type="HOGENOM" id="CLU_836771_0_0_1"/>
    <dbReference type="OrthoDB" id="10251078at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="288" mass="32950" checksum="71C4E0BAC0E3A6B0" modified="2014-03-19" version="1">MTPLRQLSLSWVAITVIVAQLAFGFLPSDLERVVASTRDEVLSRRPSSSLSPQQVEAELAEHEPLQWEHLVTQDDMARVYPYAPASGIEYQAAKGLDKDMSLLQHDFEYIAKHPYRQLTQAEVRDALHAFMKTILDATGWHKVGLEEKAWPHDGRPSEADFDKFLEQATRRGLSFGMWPIEVGNRRYLMAQLLAQTPEFRAVHGFNTATSNHIYLGVWEEVGAPKSHIFQYLGAFNYLTPRRFHGFKKETLKDTARGVNRIRMWGSSLMYVKFADEVRAPVYLDRPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ81</accession>
    <name>W3VJ81_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ81"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="161"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="417" mass="44333" checksum="34FA2C58B99DCE93" modified="2014-03-19" version="1">MDVAVFVPTPPSPLDPASRLSNGNINNMADARRRKMNSFARRHQYKVFSDAAVFRRMVWGTTHTLPHCHRDGESSAPANIDPLLGGQDPSDLGKSPLLIGAPAWASNLSDAASTLNMVPMPTATSVPAVDGLVSVQEAVMAAAQGERSAVEGDGLFTLKNTTSIVTGGARGIGLTLAAALLEAGSHVVCMDLLDEPTTAADWLMFKARAKELKLSASYVQADITNAPAVNEIITEIAQLAADAARPFTTVVHAAGVQKQGPVLDFDPAHFDWVLRVNVTGTFIVTQAAARAMKHHATGGSIILIASMSGYVSNRGLFGTAYNSSKAAVHQLCRCAAVELAEHKIRVNTISPGYVNTQMVEQLLAKEPHLLEQWTNDNPMHRIGEPSEFKGAAVFLASEASSFMTGSDMRIDGGHCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJF9</accession>
    <name>W3VJF9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJF9"/>
    <dbReference type="HOGENOM" id="CLU_924779_0_0_1"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32614" checksum="31FB97E49B1BEB1C" modified="2014-03-19" version="1">MSSASLSGLLPPDSVECATARSVGLELNGLEERFASSSGLRSLAAAAEIRDASVGLSKFSASESTHRKPLAAAARIPQGARHLAPLLTIKTTALLSKTHPEDVHSYQKLHDILDRPRIRLSFSESHTSKPISPRPLAFRLKRSVPYKTIVDIAVHFFKMAKPRGLNTARKQVSPRRDNRWADAAYKKRALGNFYKTSPTGGSSQAKGIVLEKIGVEAKQPNSAIRKCVRVQLIKNGKKVAAFVPNDGCLNFVDENDEVLISGFGRAGKAKGDIPGVRFKVVKVSGVGLLALFKSKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJL7</accession>
    <name>W3VJL7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJL7"/>
    <dbReference type="HOGENOM" id="CLU_533395_0_0_1"/>
    <dbReference type="OrthoDB" id="2562743at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974:SF2">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="506" mass="55377" checksum="2BDBF86B4E0060EB" modified="2014-03-19" version="1">MIKMQRPTLPRVYSGARNALFDDVQDLLRTEDADPSVPPPPFVVAGSAAALTTAATLALAHGNVGSNAASECGVPAYAPPLRQRVVGFYERHTKLTDTLAALGDVVASLDAVQHDIFAITGKVKSQEVRLKTLQAVSNEKRQAHAKMGSTLAKRIMNKRGTRSRLLLKAHDEAEQAAAHQAAHEAELEKNRSALTSKLDAKSRLEGDLVEYTRVAKELDEIDRTLFDGVTPEFPAEDVAEFEVKVWTQVQTFMQAESNREKRARQMLKEASPLLASVLKDVQKALQFCIESGVASNQKYTRELTTNNTSRSTVRATQPLVLRAKTSSGKLFTTLAKARGSQMLVGPPPEFRLIELHHMPGSKNANAVDERGLHKSLETSYAQAKALDSYLKREIATSLERQKKLTAETAKLQSTVKEAVGHLRSVRRAIVTAVSREESGRQGAATGASQSELGMGNEGLAAQNARNPMISKHLNEDLRKEALIRLRRLVALPDPESDDDNLYPMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJR3</accession>
    <name>W3VJR3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-fructofuranosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJR3"/>
    <dbReference type="HOGENOM" id="CLU_013784_3_0_1"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="120"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="508"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="71157" checksum="6F1C3EF85FBFC931" modified="2014-03-19" version="1">MSPVPTSTSVLPPQAVVEARTSAADAESSQSFQKRIMRPAQLPLPQQNGRLLQDSHPSASSEDSSSSSPTLFPVTTPASSGVPSPTDEVKQADMLTPHAALENVTRSTRALFEQWRPTSHFLGPHGWMNDPCGPSYDPRTRLYHLWYQWNPNASTWGSICWGHAYSYDMIHWTSRPYPVIEPGSNHDSEGVFTGCVLHRAPLGTAAEAAETGEMTAIYTAVSKLPIHHTLPYNFGSEKVVLSTSKDGGETWVPHGLVLDGPPEHLDVISWRDPYIAPWPVLDAALGRTDQQPGLYALIAGGIKDTTPTIFAYSIDNTDLSQWTFVGTLADVGRNHKAAPYGVDLGKNWEVANFFTICDTAGPASAEYLLINVEGCTEPGPARAAVYMKTLPDVQRDANGEIRLQPAHVGLLDHGCLYAASSFHDEQHDRRIMWGWITEDDLPEDYYNTQGWAGLISLPRELFHHPTSTQLGIRPAQEVERLRDGAQHICITPSDQAATTVVELAEVDSLGAISVDEVASRSYEVEMKLSAGLPGVVVAHSSDMATRTVVYVTDSQLVVDRSLSAGKEAVLAKGLKVNTSTLRAPLAPTADDTHSLRLFLDNSVLEVFVDDVIALSTRVYPDPADVGLSILRSSHAQQADLAPVNIWQGLSKALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK02</accession>
    <name>W3VK02_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK02"/>
    <dbReference type="HOGENOM" id="CLU_017092_1_0_1"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="144"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="8">
        <location>
            <begin position="307"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="66724" checksum="11E7E325683FFC0F" modified="2014-03-19" version="1">MGAPMRAARASSVLRVGSSEAWKGSREEARAGQLKARLEGENAKSTRLGLGVDKRSRAAQQPPAAQQHSSTAAQLASLFARQTAATLMYNHHSQGRYGSGSRSSGSASDSIAPQGALNALADWAARNLDPEMQTSPVSVYVERCCHPALGQPNLALNLELADYVNQKKANTPREAAFETVRKVNSRNPHVGMLGLALLDILVKNCGYPLHLQVATKEFLNEMVKRFPERPPPFPSPVQTKILELIHEWKLTLCVTSKHREDLVHIRDMHRLLTYKGYRFPNVDSRAASVMNSDNNLKSPEELEEEDRAAQGAKLQELIRRGTPKDLAQAQELMKIMSGAEPENKPDYTKQTRRELDKVQSRAILLNDMLNNAKPGEKFAQGDAYDQIAGHLRSVQPRIQKWIGDADEGDAAGSDNMDRLLLVNDLINQVVERYKQFTKGNYAAQAHIDPSIDPSKGGADAVPTAKISDLISFDDDAAQPAASASGAAASSNIMDDFASLTFDDAPASQPAASGSTAPTGLGGLPADLFANDSGSSTPRSATGSSNPASGLGNWGALQLPTTATSTSTSPRIPQSAPKAGSSLADLAMLTPSAPQPQQQQQQQAQPKPKSNDPFADLDAMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK95</accession>
    <name>W3VK95_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK95"/>
    <dbReference type="HOGENOM" id="CLU_977038_0_0_1"/>
    <dbReference type="OrthoDB" id="2555199at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="285" mass="31303" checksum="A81D1381706BE61B" modified="2014-03-19" version="1">MFKRVAKATGRKGDVDELKLATGDDTAIGVDKLIDESSSSEGEDDDSEDDESEEEGDEKDGSGDSEGESSDADAKSKAGSKRKRTEADEADAAKVEGAAVQVSIREAIQDPIYVPTEGEKKHGVLASRCIVCEAAVLKTPHLVAEHLEGKGHKRRFERFQSFVQDQLSEGQRKNLDARDAVDQMDAWKTEQDALDKQKLADAAPSKRKLARKKKAAEYRKKKKELALQRKVKKKDDKRGKKDAKSTSQQEKTDNTDVGPEQKAETASPAKKAKTAYADKRAKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKF0</accession>
    <name>W3VKF0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKF0"/>
    <dbReference type="HOGENOM" id="CLU_030612_1_2_1"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="421" mass="46959" checksum="E11B6CDDF143DC3E" modified="2014-03-19" version="1">MTGHEDEDERLERLHFATVLKAFDDYLPYCLSANDTRRRSYFSLPMAHQQLLSDLGAPLPLPALEASSSTSSSPPEPWRGFKSRLDEIDDRIRRNAGLLSAIADESRGFLGPEPLASNGSSPHDASTSGADDASNGGKGLRKRRKIPGHEIEKIQSTLKQFVRDWSVEGLPERSAVYTPMIEAVTGLYGDSDKRSQVRILVPGAGLGRLAFEYASLGYTCQGNEFSFYMLLASHFILNKTTHVGQHAIYPFVHSSSNWRTADDMLRAIRIPDVLPSRLPPTSEFSMVAGEFCEVYSQPHEAKAWQVVATCFFIDTAKNVVRYLETINHLLPVGGHWINAGPLLWHFENASRSTPTPDNLSIELTLDELVQLLPKMGFELEQRRPLPPTPYTGMLNGMLQYHYSPEFFVCRKVRDVPAAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKH2</accession>
    <name>W3VKH2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKH2"/>
    <dbReference type="HOGENOM" id="CLU_013387_2_2_1"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF145">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="89"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="188"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="473"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="542" mass="57975" checksum="35E73BDF84750F68" modified="2014-03-19" version="1">MVFARMRSLCAVLAVALTLGGEGVLALVPAFKPALPPTLPPTLPPVPANLPSAPANTGAHGAVPALPAGIPALPAPPQWADARLNDYRPSKVRLAYRGDTGMAVSWSTHRQLPVPAVLYGKTPAALTSIATSTNSVTYNTSSYYSNHVVLDHLEPGTKYYYLPILGDPLRDVRSFTTAKPRGDEAPYTIAVVADLGTMGSLGLSDHVPPGAANPLSTGEVTTIERLGMNKNRHDHIMHVGDIAYADYWLKEVVLGYINGTIAAGPELYERINEEFYDEMNDITSSLPYHVAAGNHDSNCDNSGYKNYTEAICPPALTGFLGYNQHWNMPSSVSGGFKNMWYSYDVGMVHYVVFDTETDLGEGLIGPEDVGGSSHATDGPLATPSSAQMDFLKKDLAAVDRSKTPWVVAAGHRPWYMAAKASSLCTVCQTAFEQLFNDAGVDLVLSGHQHNMQRSGPLGPKGAIDANGLNNPKAPLYITTGAAGHFDGLDAAVSPYPAYSRFVNDTLYGFSTVAFHNRTHLTHEFVSSATGAVLDSATLYKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKK0</accession>
    <name>W3VKK0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_03763</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004536_1_0_1"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000495">
        <property type="entry name" value="RecQ family helicase MusN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="601"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="806"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="16">
        <location>
            <begin position="1229"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="153"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="390"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1112"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1305"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1386"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1119"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1189"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1305"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1324"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1386"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1451"/>
            <end position="1460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS62193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1460" mass="161854" checksum="E352D019C6FDCDCD" modified="2014-03-19" version="1">MQGSQLHSRLPYSLATAYISIRSHAVAAFLLLRHSAVQSVDAPALDPTPSLNPNSPAPSSSAEHNRKEQPSSLVSLVFAVPSTSQQRSRAWNSASRVSGIGLDSAAEHIPLIDRGWFLFPFCRRHQALNQHPLQPWTCPVHSDARRLLKKEEARHPRIRHKSSSMPASTSIQDLPYRRQTAADGTSETIFIDDEDDDSAFADRPNRRDATAASGRPSPKRHLADATSSDAAHKRMRPSGADQSSTSSINSPSSAPRDPQPGSSGSLSRTSSLMRPSAPDNELDYMTMVELEAYFDFNRNSFLDRLARLAQRRHGFKDDDAWRQFNAEFDIMLRYRGTAERARLLGKARSDSTKSHPVQPDQPAPRPPPPRQPESATRIASDSFQVLGERRASTPAPTNPANHLTPSSVFRSDAGPSSSSERSKLRPQAAIASVSSTELVQPQDAPFLDTTGDDLPSSEDDGWSSDFARQLSQQPPAAAVRASSPRPQSPPPPTSRLLQGLNQLSAGRSDDRLPDAFGGYQEEENDDDSDVFDHAGDEDEEEDDDDLPEEVKFAQRGPSMQNTLSLDVVSTMPDHKWTRDVVYTMRHFFKLKRFRANQLEAINGTLMGRDVFVLMPTGGGKSLCYQLPACVDSGSTKGITIVVSPLLSLIQDQVRHLLSLGIIAAKLTGDMKHADKQTVCAEALSSQSAVRLIYVTPEFIRQSNQAKTLLNDLHRRKRIARFVVDEAHCVSQWGHDFRPHYTELGALRDDYPNVPIMALTATANERVIKDVKEHLHMKDVIQLSQSFNRPNLEYQVRPKPGNKVLEEISSLILTSHKDQCGIIYCFSRESCETVAHDLSTKYGISAHHYHAKLSADDRAMVQQKWQQNKFRVIVATIAFGMGIDKPDVRFVIHHSAPKSLEGYYQETGRAGRDGKSSVCILYYNYADINKMKSMIEKEEDKSPEAKERAIQSLDDIARFCNNKIECRRVQVLRYFGETFSAAMCHNTCDNCCRKGDTIRTEDVTEMAKKAVRLVQKLTDNRSQLTLSYCVDVFRGSRRKEITRAGHHQIEMHGAGSQLKVDEAKRLFELLCAEKVFRQRMLKNKMGFNNAYLHVGPQAKTVLEGRKKITMQFEQDGPSASAKTSTSRPNAQQQQRRVRDSDFAEFDDDAHDISHVSLSPRGPQGDRRANAGPSAGDEDFEIPEEVLHEDFDPDRDSDDDEPLAATGGNTTHGFDNDSDDDDFVIDHQRSSNMQDQCFRELKKLNAKLAEKEGVQLSQFVPDELLYELSAFLPTNTDLALAKLENPNRWFRKYAGRFVRICRRHVEATRSQHKGSEREHQRMWDQASSNVRPRPAASSSSSTPARAVATAASTPQGRAAPRKSALLAAANLEQYTYDEAAPAGAAARTGRASLGSSRPAAPAAASKTARSSLGGSKDSAAGGSAKRLTLARPFMPTSGARGAVNIAPMPLKISRNHNRPRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL15</accession>
    <name>W3VL15_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL15"/>
    <dbReference type="HOGENOM" id="CLU_049945_0_0_1"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="115"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="368" mass="41885" checksum="4E998E65B85D82C5" modified="2014-03-19" version="1">MQRDELESLLESLLPGTRISRSTHLSELWAGYGHIYRLTLSPSPSRDATYIVKTICPPPSARDEQDEGHIRKMLSYRVEANFYRDFSARLASPDDGCHIPTLHAASSSDHVVQTLVLEDLAIRFPVLAERRGTLNDAQLNKALEWLASFHARSWNTQSDSFCPPPLQAETWSGRGLWQQGGYHYLATRRDELSNIDPRSRWGQLGLHAHSDLPTVVDWCLNNPTDRSRLCLIHGDVKAANMAFSRDTRHMAMYDFQYVGIGLGVQDLAKFLTTSIPSHHLARGGEEALLRTYHRALLDRLPGGAHYEFDDLMHDWQLALVAWVRFLAGWSGGFWGNVDWLTSRVEAILTDPNWLHTIRQRYHAHTQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL44</accession>
    <name>W3VL44_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL44"/>
    <dbReference type="HOGENOM" id="CLU_042840_0_0_1"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="374" mass="43436" checksum="FB0C7B7A4958B6CB" modified="2014-03-19" version="1">MYNGIGLKTARGTGTNGYIQRNLSNVRPRDNPFTKPASSSAPDVRHTQPDAAILEHERKRRVEVRCMELRIQLEDDDVPDDEIELQVQALREKLTAQLEQQREEEAVSKVDAARLRVGDTHRLAEAKQHDERRFARAVGVESGYREGDAFDRELQERKKQERIEERRRRDEERKREWDRRKEQQAEARRERERPHEERDAGWTRHSAREEKVSRSPSPRARKRSKYSESSGSESDSSERSPRRRDDGRGKRREVQRGRTRSRSASRSSFTSSSRSRSRSRSRSSYDSRSRSRSRSRSRSRSVSRSRLRLRSRSRSRSASSRSHSVGRRRSYSRSPSRSVSSRSRSRSRSGSLSRSVTPVRALPPGPPPTRPPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLP5</accession>
    <name>W3VLP5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLP5"/>
    <dbReference type="HOGENOM" id="CLU_319132_0_0_1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="805"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="911" mass="95872" checksum="9646BC8665DB557E" modified="2014-03-19" version="1">MPPSPDLLSATSRHSTATTCSSSLSSAAFLGVLATTHFDPYSMPKSTSSSQDSHPSIPDSLPSLDGHDSLASSASSHSLHWHNPPDSRSTALAAEPSHSKIMDSSVSISNTPGPQRSTTIKAPNKPAYSASTRTAAFASTMAPLHTMLDPNTSAASDRVIASSASPPVLHSLVFADRKPESSSSAKSLAPSGVARDTYLALDEAAPRLSMSSTGSGSTCELATPENLHQSWPYDDVEGSALAALRASASTDPSQTAKAVTEQLRAIDLHATSPTDETPPATGQSNVSGLAPQRPARLQRLSSVATNATATNSTHSDESPQTATQSPRNPDAHDLASFHVPSAADTSAYGLDRTSRAASSSSLSSPSLDIDIPSRASMTSPDSWRSLLPEHDPYFASEGQLRASHPQRSASPQSLRPFSATADPDPYVMAKTSPRAPVYDRMSNSSLDTTRTSFSSAISGYSTMSMAGASKPSLQSQDSARSDSWRSLLPDDDRYHTSRDAAGAHRGGLDASPNLASPSLSDHLDSPVSFDGHNHRSAFFALDTRPGSASVPGDVDSATRRHASFSQVEPNNSQQYAATRVMLAAMQNTASRPRTQASSSSEKLPAVRASSLLPPRGGDTMEAPSMTPALSSSNTDDTSERDSWPTSRSSGGRDGLARASPVSSGPLTPEAGDALQQPSSLAAVLSQEAGGVAHVDSPAHVTETSESFVRATQDGLLATTTTTTTKTTMTTTTQFLADSQPAGKARSEAGGPDYAAPGYTEHLADAGDDDNVDGSPHLQSQPMKARTSSCSVSTPISPPSLPFLERRPAPPETDLVIETERSRYTLVTRLPGFSLDCITLATKQHKHHRTLHIVADKWDTEGGGHFERRITFPDRECDLKNVKAEFDGTTLRVYVPRKSAVNRFSSASSATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMB9</accession>
    <name>W3VMB9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMB9"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04129">
        <property type="entry name" value="Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="214" mass="23262" checksum="62AAE5C7561F7A22" modified="2014-03-19" version="1">MSPAPIRRKLVIVGDGACGKTSLLCVFAIGEFPQEYEPTIFENYVAEIRLDGKPVQLALWDTAGQEEYERLRPLSYSQAHVILIAFAIDTPDSLENVQVKWMEEVRQICGPSVPVLLVGCKKDLREDAIAKGKPVEGHYVDRNHAKQVAAQIGARSYHECSSLKNHGVDAVFEAATRAAMLVRNAGASSGGAISQSKTKEALHNDAGSCRCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMN3</accession>
    <name>W3VMN3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMN3"/>
    <dbReference type="HOGENOM" id="CLU_1533215_0_0_1"/>
    <dbReference type="OrthoDB" id="2554338at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="175" mass="19456" checksum="4F8DC2CD0E0E8A8F" modified="2014-03-19" version="1">MTASAAVTIPDSDELLCLLLQSVPSRQHRRFRKQPAMETDELMLSPTLDNQLDAAGQGGGGMLARIGALFGRITRVKHESNEHHPAVTVHNRIAETPVEDKEDELEVEYILLADKCVHPRAAPAKGKKDGRRGRCTRPRRQRKAKPSIASPPIIRHRPQLKQVAKARSKIRSPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMN6</accession>
    <name>W3VMN6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03619</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002125_1_0_1"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="13">
        <location>
            <begin position="301"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="548"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="781"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="39"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="695"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="812"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="748"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1501" mass="167461" checksum="DCB5CAD13A20BAEC" modified="2014-03-19" version="1">MSDRPEGIHHRHRDYYSESSPIPSIQRFFKKGLSEVIAKRNEADSESDSDETDNGQDAAAELDAHLARAQQAEAAKLSSQKAVESGETSRKKSTKKRMSSLLSGSKHSQENDQDHADDKDTSLRAEPEERQVDENGKQAHRRPEEVDKAYKRSRKPRQVQDPITGQTTWVHDIGKREYRRTLRMADAGDAAGRENVLRSRLADNVTSQAFPPAQPLPDSVSKIHPGLLPVFALWALLTGLGWVPPLISVALNAWMLWWAWRTLLSGAEDQRWHQERLRGEQTRAFDTRAQGEGDDSYSQGISEGAEWLNAILDSLWSVMNPELFSTLGGTLEDVMQASIPGFIHSVKVEDLAQGSTPVRITGLRILPEDHVESLKQDMRKHVKEQQRDLGSAPREDESGTGNHHTESIIEREAKRQEEAGTGEQYVNLELAFVYRARPTSSTVGAKGRNAHLLIKFWIGARKLLMLPLPVWVEIKGFVGVVRARVQLTSDPPFVKNVTFTFCGLPRVGIEVVPLHINTSHIPFLSSFIESSIDAAVGEFVMPSSLTMDVGEMLMGDNIKREVNALGVVVVYIHSAEDLEAQDLRGGSDPYCTLSLAKVGKILYSTRVVLSELSPRWEERHVILVTREHLDSQDKVSIALWDSDRFSADDMLGCAEVPLVDLAKHPNRLYRRRDTLKGLDRERTKQGTVSWSLGFFSKAPSTRKPEGAKTADKDKSEDRKAEGNDQAAARDSRNAHAGDQETDVEVDSEPERDGRELEDGTIEKDSPLSQAAIDEERKKQTRHQATAVDFEPPDPRLPSGILSLQIHQIAGLEVTDHHRSKRPRRQNEPGQDVEAAETENDPDEAPSAYARIILNDEIVFQTRTKALNSNPFYNAGTERFIRDWRRTLVMVVVYDFRVREADAILGVVPIKLSELFKQSSQVTQFFPLAGGVGHGRIRLSLLFRPIQHTSRARKKLGWNIGTVRLLSSPVATDFDEAKGASAHDVHLVALRASTLAGSAKIAANRARYVDRESKDAVEWGLDEAEFPYKVPARRRYAAPYVIEFRALSALGKRKTILMSIIWMQDMLDDDVADMRLPIWRPLPGNDFHRLRQNYHNYKNEAEAEALGVERIGYLHVKMQFKSGLGKIHTKFDNNPGAKIVMDAWRVCTALGLRSVSGDFANARLNEDGYLEDVDEADRESEPGEAYSSDSDNENDREPRARASKASGDPTLGEDSGEARGSSSSADLDTPDGSGVERSRSLKQKFAEWKAEKDELHRQHKGIKQYKPVRTLDWVGQTAKSAGAGLKNKFDLQDRRPVPLQRRRVAYVSAEGSCMALAGGVGQEWEKEEESVLLFTASTHVLSISHYHIMVRITSLVAALTALALPFVSGQASNDDPRGKVLYVNYPSCDHYQCQVIWHQNEGVYINWLNAPKGGLRIELAPADGTSGLKTYTVTNKVGSVHGFSNRKCNDMGTGEKCGRFDWTVPANVKPGKYQIEVTSLAKPQLVGYTDTVVIKKQKSKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMR0</accession>
    <name>W3VMR0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMR0"/>
    <dbReference type="HOGENOM" id="CLU_048924_0_0_1"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834701" description="Mitochondrial import inner membrane translocase subunit TIM21" evidence="11">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="443" mass="46885" checksum="60EA73D37E33F0D8" modified="2014-03-19" version="1">MAAAHPLTALAPSLRLLGVAVAGPAAASGRLAYSASASTCGLRALHSSSKRRQSKGKSSSDDLKASKAAFTQRQILDELRANSSSSSSSSSSALQSKPRVRINATAEAALDAASGSRGGGIPLGMAGLSVGGGGFGSEPTLIDRATGQGKPWSQLKTGQKVARATVQSSRTMLILGGGALTFVLVYALTSELFAKNSPTVIYADACKRVQTSAEIASHLLTPYRFRTSPTATGSSDFSPLNPPSVKDRRRSRSVPSVSFTDERTREEKMLLRFWISARDKTEEWSWWDSARYEVVEAGKWVGRKVTEGGEWVGEQLGLDLGADEDEHHHSEPSTAIASATTKTSAAASDNVLTRTWNSALGGLGNVVRSSTEAITSTLVSPSSAATRRHAEPGTWSSGEVHAELVKDADGTLQYQTLFVDIPSSAAVTRQRVWIVRKPGEVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMZ6</accession>
    <name>W3VMZ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphomannomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02708</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMZ6"/>
    <dbReference type="HOGENOM" id="CLU_016950_0_1_1"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="8">
        <location>
            <begin position="45"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="9">
        <location>
            <begin position="232"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="336"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="7">
        <location>
            <begin position="553"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="67054" checksum="947821511BDE29FA" modified="2014-03-19" version="1">MSSDLLAQAKRWLDKDPDASTKRQLAELIESNNVTELQTCFNGRLEFGTAGLRGVMGVGPSKMNLLTVLETTAGLAEYLLKSDEAKAKSEGVAIAFDGRFGSKEFAYSSAQHFAHRGIPSRIYPTPTPTPMCGYAVKKLGLAGGIVVTASHNPKEYNGYKVYGPAGTQINTPVDGLIADEILKIAEETQPPTLASLDECKQKDIIKEFGDEMLTDYIKDVQALGTFASEAVHGKDAPISIAYSPLHGVGAPSIERLSKEVVGLTEGVNFWISEEQRKPDGAFPTLEFPNPEELSTLELVHRLSEEKKTGLAIVNDPDADRLAVSARDATGKLRALTGDQLGALLGDEILRRAAKANGGTAGVWTLSTIVSSRLLARLSGHWGGRHVETLTGFKWLGNVARGIEAREGTGSFGFGYEEALGYMAASSVWDKDGLSSYLLIVSMAFDLAREGKTLWDRLEELHRLVGLSVTMQKIIKLSPSMKGTDVMTKVRADLDAGKKSVADKAGKEYTFSLVDDLKSRPAYDQAKADAGDLSIPKNDVLRFYVPPSHVDAQAEREQQEIMLGDVRVIVRPSGTEPKVKIYTEALGQIRDGEAYPDAVQRVSRELEEVVDAFWAWMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN02</accession>
    <name>W3VN02_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear rim protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN02"/>
    <dbReference type="HOGENOM" id="CLU_698673_0_0_1"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43042" checksum="4C098DD844B1B692" modified="2014-03-19" version="1">MASYGSSPAPSPGSPAYRKGVAFGQPGWRASRASRGRASGIDSPLYRNSPAFGSASPSLRGGTPSSLRGTPQPTGPYGLTPSLSVASINQQPLRPEDSAAGPADLDRLGGTAQPSSPAPLGQPSKKRFIRKRPLLERIQHWPIETYDRLTSYVLDIEEQLFADQAGNVLGAILHALSLLALFLSPESSLGSWIMNKPAHRKAQNPAIAYEYLVGHAADEYAMADALKRHARKSAVYSASDRFFRIASTALFLAIFVTSCINAYVFFTKRRTYKFYSQPKPHEPASSSIHTKQGIRQLLMWDPTPYAANLFATFSPAHGVIYPAAALIEMGAAAWIIFVFLLVAVSAPVHLILHQYQQLLKDKGVVQAAVLTEYNEKYVYPRATPVVRDQTTQTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN93</accession>
    <name>W3VN93_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_03799</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN93"/>
    <dbReference type="HOGENOM" id="CLU_002976_2_0_1"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833242" description="P/Homo B domain-containing protein" evidence="18">
        <location>
            <begin position="25"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="592"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="898"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="942"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS62222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1013" mass="109818" checksum="0D2584A3A0FF654A" modified="2014-03-19" version="1">MIRAIKLNASLLVLLSGMLALATAQIADPNTGALASSQCSSDGGALASIPEQQHKRSTHNHWAHQKRTVPLPSKRSYDTHHYYVVELDPRAAQDVDPRDVAHALDADFVERAGELPHHWLLRSEKPTSHQAPALDKRASSSASPLEARADVPEHHDPVLQRWSHIRRSAREPGFTTKHNLSKRHHLAALSIKAVERQEVRRRHKRNIIYDPEQMPHLYPEQRDPIPAPDGWPFRVRDPEPGPRPPVIPTAKTAEMMAQFNIKDPIFTDQWHLANNRKLGNDLNVTGVWDQNVHGEGVTVCLIDDGLDMHSPDLKDNFYAPGSYDFNSHTDLPQPRESDDQHGTRCAGEIAAVKNDVCGVGVAYKAKVSGVRILSGPISDVDEAASLNYAYQENDIYSCSWGPPDDGRSMDAPKGLIAKAMLNGVQNGRDGKGSIFVFAGGNGGASDDQCNFDGYTNSIYSMTIAAVDREGQHPWYSEMCSAIIATSWSSGSGDHIHTTDVAWNGVNRCTASHGGTSAAAPLAAGVVALGLSIRPELTWRDVQHIAVRSAVKFNPEDPDWQQTQAGRHFNHKYGYGLIDAYQFVEETKRHKLVNPQAWYESPNVTLPATETLITEAGTESTFTVTEDHLRNANLAALEHVTVRVWITHQRRGDVNVELISPHGTKSALARSRRYDDATTGFPGWSFMTLKHWDESPVGEWKLRVFDPAHPNKVGNLYAWSMSLWGAAIDAGKAKAWNFPEDSVEFHETLAAAPETTVIKLPPSYTASAQLKKPTDHLPLDHGLAEGESHVDFTNHNGSVPIGAVQPEADTGYIQGLKKNSTWVVVAGGLVIIFAASLAAFFVMRKRKLGRGGAGGGGGAGGPGYESLAGDEEVAMGELDDGARGARGEKSRRTKELYDAFGEASEDEEDEQLAAREGRGLLGRRGAGGADEPYRDDVDDDLDGDRRFALHDGGDDDDEADTTLAGDAEGDKAESRTGSPSGSGSGSGTGSAADGSWQDAADDGRDLIAGLSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNI8</accession>
    <name>W3VNI8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254982_0_0_1"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1099"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="658"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="930"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1257"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="963"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1289"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1308"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1358"/>
            <end position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1390" mass="150188" checksum="8AC3C3F265B51AAA" modified="2014-03-19" version="1">MSDNPSQAGSSANLVAATPPSTTAAILGASSNGWSPLRTSKQRPTSTVSYSQPSPDHHEHEEHPSLHSPKKQTQNFKSLRNHGLVSNSIFKQIDGGSPIASSPVASAARTQLPSPSVGLGIGVSASTSKPAHSPSRKIEDAENNNPFSLSPTMPVKGAQRKIPRKSLGRLHESNYVSNSVFRQQPAPADELGSPRSPPAASRALASASPSTSAATKGLLTSNRLHGPRFMHDSPQSSSADQATRADIPATMRRERRKTVTFDEILDVQEFDKESSFDTESLRDADEPHTATDAEDADFWTSDPASASAPGPLQVVNGGDAHGLSDDASEPDLSHDSHETSSVEEPPSPSPGDSSLQLQDLSVDEAMAGHEICQEDPVFSPERENSFARLSAADRVDSMMDELLRDDILSSPSMRARQAVPSPLAAQAQQSQPEVRLDAGALPQLPAWSPISFEADDHTSLFNDLNRSRTQPDIAPSPITAQPPASRDAPRMRPHISRDAILQRVAMQKLSRDQAQAQDAPLDDKAVEQAVQAATADAKLTRPNASQQKRMPRGSEPGPSATSAFAAETVQAKPMAASRPSAPPRPLMVEPVATEVKPAPAPSPVLPLDQRSSPLDLLGSELKETVELAGEPTIPTDANFAAPQLGHIDAGPADRVFADFAEPSAPQNEQAAAAPTHLTPAQQAEQIIARRRSKNGKARRKRSMSTGDARAVFTAASASEPSDEDSGSTSFVSETISESPEEQLELPTRQSISADLAKSKAMLDVSLQRAIEGGFQLNMEKELTRIYQKGESNYKVNDRGAFQGIDDKVTHSTTAGDVDSGKAWKKLRRPSDINDYKKEMRELREASNTRKASGKVFVMVDSFTPTDLPVPSRPTSFHCILDNGLHMVKTASVPLRPGRVTSNIAQEFELIQHKNLEFSLTLVVQRDAHLMEPQRPSSPTRREHGSPTLKGLSRFFSSPKKQAAKREQQEREAAAEMAAQAARAEPMLAYINREGAFGRTGVIFERVASQCYARCMVLDLPVHGVSNPTGSISGPSSIASRTHVSMLSQDFRQNLNKVRGTLRLKLFYLPPLPNIPRDGLPENLGECIRGIQHAAWHRADPWQAGTLTQLGGDCVSWRRRPVQAQGQYLICFNAVTKKPTVKIDLSKAVCIEELGNHVNGGSMIFPSAGSQALGRSKTMASYATSATLAEEEDADANYHVDRSFRITFADGERITFFADTEAQKTQWVKVISDVIANEVPPNPLWAQVLLEGIGAKAAQPERAVKTSQAFPSRKPVPTVEEEPSTPTQPLRHEADAVAKSEAREDRASRISTSTPQGATPSRLPIRAAHPVAASAPTSERGSMRGSPLPQRPASMIRTPVHDPSNRAAFDRLKRAGHLRAQTEDLTPQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNX2</accession>
    <name>W3VNX2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Monocarboxylate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNX2"/>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54151" checksum="79661E4E2E344183" modified="2014-03-19" version="1">MSLSTNGVPVPPLPTTTTSERKDAADGHPENVDLSTTTNVGLSDSQFTIREGGYGWVNVVCGFLLNAATWGVNTTFGIYFSFYLRNDYFEGATPMRYAYVGGLSVASCMLVAPFVNMLWRSSGWFKTPLYLGMIFISLGQVGAGFCKTYIQLLFTQGLVFGIGLGLTMIPTQPLLSQWFRRKLSYAQGIAAAGSGMGGLVLANTTRYLIQEKSLKYALICNGIVSFVVLLPCITLMKSTESQPMHFIPSRLRKQKVSESPTARIKKNPLELKWFFHPGYSFVLLFGVFSMIGYFVALYSLAAFASSGLGLTQKQASTLQSILAAGQMVGRPLCGFLLDLIGRHPCTIMIQILAGVTCLAFWLPARGFALLVVFAITQGLLGGTVWSSVAPISAEVVGIRDLPSALAVFWFATVLPAQFGQPIAVALINHSQNSLGRRGANAYLISIGFCGACFIASGLMLCLSWRYVRARNHKEQLQSSTPESQQDTVDSTAPSQATEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPI6</accession>
    <name>W3VPI6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01749</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPI6"/>
    <dbReference type="HOGENOM" id="CLU_015166_0_0_1"/>
    <dbReference type="OrthoDB" id="1747031at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="232"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="361"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="470"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="161"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="60228" checksum="1C5136387E0BA102" modified="2014-03-19" version="1">MASSRAGSSSSAMRSDLTEPEAYPTMASTSVERPPMGKRRSSFGQGAPRKPVSRTKKAVAAVTGAVTTSFLMTPFDVIKTRLQTQSSAEPLFYPSQHLATAPTLTSVTSIDKGKAPVKGNAPRLAGGFHAHPATCCQQTFFTSNRQPESILCRYDPRQASSSSTASTSAASSHSSSSSAFFSARTPSSSSSTQRPAHRSTSSRFGRHTTSFSASAPPRSSVRILPSPPPAPTGFLHPSPSAVTANGSSSCACAFPNQTVAARELKAAASEQGRLTGLWDGVIKVGRAEGIRGLWRGLAPTLMMTVPGQVTYMSCYDFFRGKLLASEDSARVQRAFRQDSAATGRELGLAGKAPSLSAVTAQSLYASLLAGALARSISATLVTPLELIRTRLQASSRSQASLTSILRGLWVEMRTTSIGAGGGPLILWRGLTPTLWRDVPFSAIYFAGYEAGKRSLTGGGLGEGNAAGSGEEFGVAFVSGAVSGSVAALLTHPFDVVKTRLQTQGSNQPDGRLSASLRGNQQATNGVWNTMRHIIATEGTAGLWKGLSPRTAKVAPACGVMIASFEVVGRFLADLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPI9</accession>
    <name>W3VPI9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01676</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPI9"/>
    <dbReference type="HOGENOM" id="CLU_394390_0_0_1"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="529"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="578"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="790" mass="86870" checksum="ACD1F7357DB59DE5" modified="2014-03-19" version="1">MASALGCGDRAGSASKNDLSRVAPWRVEKQGPHGAQVEASKFKALPLLGKKERGPQCTLDPGTHLFTNPHTIVNPLGLLSTSVGLKARHFNVFQGILQQPMTLNIGGCGSQSAAAQLADQPLLEASQPGPSNVPDAHRCPYEGCGKSYTKASKLAQHIRSHTGERPFVCDHEGCGASYMRNEHLKAHQRRHQDPSDKPFACQEEGCTLRFWTTSQLKNHVQACHADHLSTATGASAHDYPCTEPGCEQTFHKRKQLRQHIRDHHADHLNAEATARQEEAASDAEQSPSALPFVCPHPGCGKRFASNSKRKTHARTHQDGRYTCTMQHAQPQRQENGEQASLVYRFPTWSALQAHMKEAHPPVCPWPGCGRMFQRQDNLRAHYRRHENRKLRLELEAKVLEGSHEAELNHLRAELSDDSGASSSEEEEEEQEPHPTREPQSTSGFDQRLPVHPIAPRVPQQASPVPSDEDLVNKAAHLRSTRPRRGGVFRDLSSPALSIITSASGGTASVRPGSVATSLTSARDPSASAFPCTWNGCDKVFTRKNTLSIHVRTAHLGERPFECPDCGRRFAHKHLVSRHRRVCTGTRSSPEQTTDTRSRLRFSTSGNASHDEAEGQDSSSEASSMISDSDGESETRFEGSQERNSELLDGNAATIGLSPSIKPRLLDLLTGRGYSSAMTANKQVGSEKRPASENGSAKMPAKRRRTTRDRIFACPWTSICHELDEQVLDPALRATGAESPSTAAATSRDACEHRFKRLYDLRRHLRAQHGLDLTADELSAITDRTPWASVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPJ7</accession>
    <name>W3VPJ7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPJ7"/>
    <dbReference type="HOGENOM" id="CLU_430949_0_0_1"/>
    <dbReference type="OrthoDB" id="2550291at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="630" mass="69137" checksum="3DDE02D6B2A2E820" modified="2014-03-19" version="1">MTMNHPNRAPFSARKIFTRPANLHLVRSNGKGPSTLAPVDTASEEPHSKMEDLKPHFAQPPIQTIAPWTSLNASRQETTPHPYSSFSLSGESAWASSPCSSVMSRQLSARFSTARTSSKTVLKAGELTWAHAGSGPKRIASGFEWSRRRQRLHEPVGGPSQTVFAVLERHNLESPRRESYAARADEYGSLQRTPSSIPYLASPGACDPSPFDNNELKSLVPPPVPLCLDDLSRWTPPSEWAVSESGSSSQDSNGRSSTSSSSDHLSTPKSSPGTRRDQQETYLNFYSRRFDPSRSVSGRQLMQLLITSDSTVEIKQYQTEVSDPGSSEHPIQWQIIVTGHSTAQRSSSEFYSTSTFANSDSTEFWTVCTLTSPNVAELRSWLDCLESVIQACRKLSSSSSSRSEYRRSSSHSILATIRLLEQLELQSRCERGMHRSPSSKVDGEEPTTPVVSSRYLSPTAARGSTTAPDFSSGFSTSSFIDSYALSPASAGADVAVQNTSGMEALYDYEEAYSSIMQRFSEYEIASPMEALPTPARLDPHRGHARSACLDVPVSPCSFEIGRDRWVEYEGVPGSPLDPWLSQHISLPVSGRKMREEDGFGDDAVMRIFAEGFRRRSSAATTNSIILSAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPP7</accession>
    <name>W3VPP7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPP7"/>
    <dbReference type="HOGENOM" id="CLU_039475_0_1_1"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF263">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="126"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31767" checksum="C556F381A6CD89BD" modified="2014-03-19" version="1">MTTKEEYTLFYWPEIPGRGEFVRLCFEKAGVAYKDNDDVPYFSNLLSGKQESGVDTPHFAVPILGVHVPAEASDSSKKAKTDDAADVKHASGGTWHYISQTPAILNFLAPRLGLLGDADKLEGLERDVAIAHIQQLCATAFDLNTETHDTHHPVSVSSFYDDQKAEAKKRSADFRQNRLPKFLGVFELTLHKEGEATNTETTGRRLVGTQTTVADLAVYQVIDGLLFAFPKCMHHLKQSGKYDRVFAHHDELAAELKHYLESDRRRRYSNGIFRHYPELDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPU0</accession>
    <name>W3VPU0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SLY1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPU0"/>
    <dbReference type="HOGENOM" id="CLU_016216_3_1_1"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="77936" checksum="7D4261F72BAEA7BB" modified="2014-03-19" version="1">MASASSATASSLRTAQVNSLLSLLNLNTASFNHASSSSSVPGSTYNSRPGSAAGQNDAGGAGADPSIPSGPPVWKVLIMDKVSKNILATSLRVQDLRENGVTLHMQLHSDRPPLPDVPAVYFVSPTSENVQRIAQDMKRMLYENFYVNFTSTVPKPVMEEFANLVATDGTGQLVQQVYDQYLNFIVLEPNLFELLPDASPAPSAAAANGASAPTSTVSTYERLNDPKSGQKDVEDATDRIAAGLFSTLATMGALPIIRSPRGNAAELVARKLESKIREHMTSSRGGSNLFSESASGGQASWSSSRPLLVVLDRNVDLVPMLAHSWTYQALVQDVLDLQLNRVTVVSSEGGVTSQKTYDLDSKDFFWSKNSATPFPHVAEDIDAELNRYKADAAEITRSTGISSMDQVGQLDATSNAAHLKAAITALPELTQRKATIDAHMNIATALLQGIKRRGLDTLFQLEEAIARQKKETILETVRDAQLEDVNDKLRLFIIFYLSAPDSALGRADVDEFERVLREQGADLSALSYVKKVRELTRMTMLASAPQPASVSDAGSGGFRGFSSLSSRLTDRLKDSGLENLVQGVKNFLPAQKDLTVTRLVASLMEPSSAAAQALSETDEYLFFDPKAPRGRAAASGGVKARQVFNEAIVFVVGGGGYVEFANLQEYAARTAGAAASAGPAAANAVGAVGGGKKITYGATEILKPIDFVRALAHLAGGDVAASISSTQSTAAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQC1</accession>
    <name>W3VQC1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQC1"/>
    <dbReference type="HOGENOM" id="CLU_062658_0_2_1"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="106"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="272" mass="29547" checksum="E7D6E5D5328CEB78" modified="2014-03-19" version="1">MLGRCTHCLARVPPPLRTALVRRASPSLAALAPPQRTLSTSSRLRSSKILSFNTSSTMSSQDAKVLKTAPLQDSDAKWVGLRSIEWVDPTGKQRKWESADRKTRKGDVDAVAIMTIIHRPSSEPHILLISQYRPPVGQSCIEMPAGLIDAGEEGDEGTNRAALRELEEETGYGTDKQGGKVKIQETTPTMFNDPGLTGANMKMVVVNIELADNADEPVAKPEEGEFIEKYLVPVKGLYQSLKDFQAKGFAVDARLAHLAIGLEVGAGKMGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQD4</accession>
    <name>W3VQD4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQD4"/>
    <dbReference type="HOGENOM" id="CLU_299604_0_0_1"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="399"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1003" mass="106739" checksum="7DD42D286C502468" modified="2014-03-19" version="1">MLVSAPLQSYDRASIHRPQYHSSRPYHTPTEKGTAGTMTLSSSHADMAHFTDGRPAVGTSSNHSHVETSSSASSESASASLPSANLAQSVPTRPKNHVRGVASDSRVWTTGRGFFEGRYRERQSYVSAQEQKDLEAERDAILQIQNVQAAKRRAKMMRLTPAFPASRDSTRTPSPPSSEASSARTASDDVATPPDSRVPFPSPKTRIGLAAAQNMAPLHPGSRKALALKANSPGPEVLGGLSLDLQCLPSPAGDRSSISSTTSTNSELLRKKSGEPVKSSLKQYSGSYMVPRSASDAILPSSAYGTKSVPTTPSAPKFVHFDTQLEHIKIFKVKGRPQAVSREGSPEHTETETEEERDYPWFGSRRGGSLGRTAGSRSPTNPSTPPATEPDEQLVLRLPNFPSSAKLSLDKDIFLERIYLSDDLRSVRGTVQVKNLSFEKWVAVRFTLDHWATVNEVSAEYSESIKDGTADRFVFSIKLNEVLNWPRGAGLNETKTIFLCLRYTTGGREIWDNNDGGNYQLDFRKRPAQPAEAPRLPPTSAEGRAAAATFGNTVPRRYTLSSMGPTSTSSIIEMGRRTGVYGQKATRDNAMERLKQELERLRSDEEEAEKAPMSGNFASEMSKRRSPPVSPGGAGKPSSPSTWSARYDFGASLRDPKSGSRKTEAGRAAALDYFSARPSAVAASSPVRSSFVVSAATPSPDGSTPRSVAELVPKFGRLGMLSPGLGEVVIEHAAVNSSNTSSPTGSLLQVPQVGSIASTSPAATSGTRFNSFPPNRNGQARSMFGIWDDEASGGNGSGSGSASGSASVSRSGTPPSPIGFATTRIEIKGDGTVLEDYTPDGSQASPNSLNNSPNPFSPALSASSVDSDSTAMLDTKPGMTSSLDNLGNLSGPSAYRFLRADHLEGRTRPSSFTAGDEAEQHGYSSSALSSSTTMSPSSELATPEEEFMRPSNLTSFNELVARFCWNSDNQVPQTSPDASGLAAHTPTSASGRSTPIARAGGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQM6</accession>
    <name>W3VQM6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001872_1_0_1"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000583">
        <property type="entry name" value="MAP3K epsilon protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001504">
        <property type="entry name" value="Related to MAPKK kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF4">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="146"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="734"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1426"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1498"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1627"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1426"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1498"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1537"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1571"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1688" mass="183985" checksum="020354704B0F598B" modified="2014-03-19" version="1">MQPARSSLDGFSASNSASRQPPHTRMPAMPPASNMLPPAQSTLRFPSHAPPLQAAAGNEASIAPSDGTRRSSHATQAVVERSRQPSTSSPAQSSSASTSNSQHRSTAPHTSNRSSSSSSTSPSATGAAPSATPLPPPSPSTTLGNYQLGDCLGRGAFGSVYRGLNWMNGETVAVKQIQLGNIPKSELGEIMSEIDLLKNLHHPNIVKYKGSEKTKDYLYIILEYCENGSLHHICKRFGKFPEGLVSVYISQVLQGLVYLHDQGVIHRDIKGANILTTKDGSVKLADFGVATKTGAMSEYAVVGSPYWMAPEVIDQSGATTASDIWSVGCVVVELLEGKPPYHFLAPMPALFRIVQDDCPPLPESASPVVKDFLLHCFQKDANLRVSARKLLRHPWMSSARKQLDQLKSGGSLRVGAGGTFNTPHEEAVKSVQEWNQALKEPPKQAVQRLQDPDTVRAPIQPSLRRVNAIAAELGTAKPLARKTRHPTRPTLPLDFSPPPSVPRKDIRLDTSSRPASRLIDAVSRSPNAANDPAVTAHSPLVALAPMTRQPSSPGNGSGFRTPLAGATPATSLMDQRVKLADLQQPERPDDNWDDDFEEDITTTKIAALEKTSLPSQTPSSSSAKADFRPSSEATTADSLAAGGSTRHADLPASPSRPSASEADFDQRTIRPLSGPILRSVSSSPQVRTLSQKPTPPSTTLSSFSADDEEDYSDLVGDGQEDLLNKRIRDLQMKNSAGKRLFHPNDLARPSTSKAAPKVYNLDTADPASASPSRAIDRRRQASSEALRNSLGASATRPPSNPSSPQATLRLEKDEKWKQMRRTLGKYSEDQSAEDYSDLFGNADAPGNGKEDANVSGGNTLQLTARLSNRSWLRDDENDEDDPFAEIDEGFNAEADMEANVARDQHARMCAFVTELVESLDPRTEVDELLQVCEDIDQILTDMPEMKAQLLSSHGALALIQLLEAAADRELATRLLGILNLIIFEDPEAQENLCLIGAIPVVMTFTTKKWPHDLRLEAAHFVFAMCSTSRLTLQFVLSCRGLRTLVGLIDEDYLEQKDLVWIGVGCVSSVLELQSPASRNDFCRMLAQEGLLEPLSSALQSVIADDEDGYASEARADILQILLIYSQSDNFLKKQVATRSVLRRILRSASMLDSEALTLMLKVVKNLSMSPMLLDEMQNANTIEILSNILAQHHSGPHGTEISNQVLNTMYNLCRLSKSRQEEAAQAGLLRVARTNSPMRQFALPILCDFAHAGKATRKMFWQHRGLHFYLKLLEDPYWQVSALESILIWLQDETARVDEVLVQPTSVDALLCVFATSKANSFENLLEPFVKVCRLSGGIVTSMARNTLFVKRLLERLSHPKAVVRLNLLRLTKMMCDLRGEARSPLVEQLHVYEAVERLSVKDNAVLVKELARDILSQRHAEREVGRTVRRTLSDTHMGEGNRSPPGVGTNSPTSVAAALPGTTALGQMVGMRASAPYRRKISNGTSGDAATIHERSISTSLVETSPSSSRSAAMRGLVTRLGQPRRSVTPNRELMSESQASSSGSFSSRTSPLMPMDPLPQGEVVRQRQHSQPHSMDRSGSTPPGREFEKKLPTLSIGHVGMRAMSPRMRSISNEVKLAAAKAAAVGDSYQPQQRSPLMHGSVDSGPRRVKPDRDEAENGEQMDRDRTMRPPSRRPIPSLPPAHGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQM7</accession>
    <name>W3VQM7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQM7"/>
    <dbReference type="HOGENOM" id="CLU_845020_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="329" mass="36234" checksum="943E2DE8C4445EA6" modified="2014-03-19" version="1">MERYDWPLGREDATLQTIWSGPTGLGYVNGDVGKVARKPVLAFTPESRIKKINNEYCRFKEIEEFNAKEIEELNAKLNAQRRAAGTVGPVRQSGSDTDIPPVGSVPAFWSDFALACGCEAREPKLSDAQRRSALSPEQRIGALRAVALSPVQWSSDVEAGVEGRPASFTSIKRPHLNIAFDLDPPEPLSSTSCDGSSPSSVSVSLASHCTDARWAAASDYENTETFFLSNTNINKDDVNTPRDFVSKIPDIQNNDPLCFVGKIIVGEISRTYPNTDHRTMTIVMTIVIGLWSVSGYVRRISFTMILLTKFSSVAIAEVRRGQLHLLIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQN2</accession>
    <name>W3VQN2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylisocitrate lyase</fullName>
            <ecNumber evidence="2">4.1.3.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQN2"/>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF13">
        <property type="entry name" value="MITOCHONDRIAL 2-METHYLISOCITRATE LYASE ICL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="283"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="499"/>
            <end position="503"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="613" mass="66714" checksum="FEB33B0DFA5CF8C3" modified="2014-03-19" version="1">MSSRFVAARLARVNAARVQSAAAPSHSVARLSICSRASRSSLAFAAPSTFAGAVRMNSTNATSLNPPPAPLRLQAPTAEQEQADYDAAVKQVQEWFDSPRFKGIKRPYGPEAVVSKRGSMPVQPPASSLMADKLFNLLSEHFAKGTPAHTMGAIDPIQQSQMAHNQEVVYVSGWACSSVLTTCNNEVGPDLADYPYTTVPNQVQRLFKAQQHHDRKHWDERCQLTPEQKAKTPWVEYLRPIIADADTGHGGLSTVFKLAKLFAEQGAAGIHLEDQLHGGKKCGHQAGKVLVPTSEHVNRLTSTRYAWDILGSSNILIARTDSESAKLISSSIDARDHEYIKGAFNLPEGTRSLADTLAALEARGASGPEVDAAEKAWMEKCELLTFNEAVAKHNAANKQGVEAYNAKVAGGVSNGEARAIAKEVFGAEGVPTWCWDAPRTKEGYYHFKGGVAAATKRVKIFGQYADMLWLETKTPDLKQAQGFAADIHRDLPGKWLVYNLSPSFNWSAHGFSDQDLKNFVWDLAKSGFVFQLISLAGLHSTGAMTCELSQRFKTDGMLAYVELVQRKEKEIGCDVLTHQKWSGAAYVDRMLQAVSSGSSATQAMGADSTERSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQT4</accession>
    <name>W3VQT4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQT4"/>
    <dbReference type="HOGENOM" id="CLU_000631_9_0_1"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="298"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="869" mass="96650" checksum="BE07514543280245" modified="2014-03-19" version="1">MLVERPLTNLAPAAKQPADAFVLTNEKGFEWSLRLLTPPVLKINVTGPNHPLPQQSNVLWSQKPLAVQSNIDAAAKKATISVEGLTRDLTVQWDDTPIVEVHESVEGSSEKVRVFGDTPHKSYCFSDKGFTRYTRFNNHNLHVGMGEKAAPLDLTHRSFSITGSDAASYDAYLSDPLYKHTPFLMSLPKPVDVDGNAQPMTSVVGIYSASNSDANWDVGRFIDEPWTMFKKYAQHWGGLEEYILFGQHAQEVVSQFSDLVGRPLLVPRDWLGYLASGMGLGESDVPIAQELLSGWPGMCKQNDIPCSAIHLSSGYTVDDEGNRLVFTMNKKRYPDFAEMVKTFHKAGIRVTPNIKPYVLQAHPDYQKLYEAGALFTDPNSGNEPVVTRIWSSLPGFNALGSWVDLTSKAGRDWWRRGVLELCELGVDSVWNDNNEFLLFDDAFECKNELVGDAKTDGNRTGKPTPIGLLGRMTNTELMARESHDALVSHHPDRRPFVLTRSANVGTQKWAASTWSGDNRTSWHNLRGSIAMNLNAQMSLLQSYGNDIGGFAGPLPSPELFVRWIQSGITQPRFCIHSFKPCKEDPLGVKLNNLPWMYPEVVDIIRATIKRRYELLPFINNLNWRSHVAAEPMNTWLGWGEFASDPEVYKKEVLEGFDYWIGHGQLLSAGAYHEGEHSRRVYLPAAGKDDTKVYYDTNAPFHIHSAGKWVENVSTPLSHFALFAREGTAVPVGLPKVTLTQADGIATLTGSGTKILTEQEGGQVVHDEWRGVELFPSPADTDKAGTYEYTWIEDDGVSAKPAVAEIKLEFSSSKDEVTVKATAHKNDFKPLWGNTLWIILPRPDTRRVQGATKTMPYKGQTAYAITVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRE3</accession>
    <name>W3VRE3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRE3"/>
    <dbReference type="HOGENOM" id="CLU_619936_0_0_1"/>
    <dbReference type="OrthoDB" id="3355573at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="428" mass="46469" checksum="52351604DD7F180C" modified="2014-03-19" version="1">MLAAQPTPTRATCISAPSSSLKPALTIKASQLAKAHHRVQVPRIIITPPDEPARFSSALPEQTYEKSVLFVPVKTEELGWDEHGLYWNGTYAYPVHQIYDKEGSPIGRRRKGPQGYRFEEYYGNKKPRRPSTSSHMDDTVEEASVRLEEPAPARILGYNRASNPGQDEQEHIEKPAECDEDEAASPTSPTLSVASDLTETEDSSSVCDDSSSIWSRSGGASDDAESECTSPGVMSPRTDAEEGELSADALSAKLSDLAPTERVSKTTWTSLGTLPSSIVSPSRSSSLPEPSSRNKLDLSNEHRSSSTMIVSSPTEQRRYSTPSAYSSIIQDLVISPFAKQSASPLRSATLPRSRSRSSHAASKPSSVLRPPPPSSWTSSGATRSSSATRSSRRSFPSAPESDFDAGWNFEAQGASLSHHWDHSFANHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRK4</accession>
    <name>W3VRK4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRK4"/>
    <dbReference type="HOGENOM" id="CLU_067577_2_0_1"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000013">
        <property type="entry name" value="Tubulin-folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="201"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="267" mass="29078" checksum="10B9B9E24A481A8C" modified="2014-03-19" version="1">MSVVNVFIHAPSTLVSAERRVPSTIPLHDLKYRLESIVGVPPSHQVLEIHSSRTDHEQQQQLAGPGPFAASVRSTLVAAVPPNSDVESRSLEELGVVDGMAIKVLDTRPKELIQTFTDESLVDKYVMDDDTYAARRDTVLAFKQRNKLGRFDPSKDASSSSGDTEDLPTELAVGARCQVDLLSGTGTTGANQRKGTVRFVGTTKFATGAWVGVEYDEPVGKNDGSVAGERYFTCKPNFGSFVRPDKVQVGDFPADDFDLDLDDDEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRM3</accession>
    <name>W3VRM3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRM3"/>
    <dbReference type="HOGENOM" id="CLU_017785_0_0_1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="227"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="738" mass="81605" checksum="079999568B3CD71C" modified="2014-03-19" version="1">MSRSPTRRRSGEIAPAVDKVNPTETRSITFEWPLHDLKEHFDSSKSDTKSKVIRSVPFGGGRWTVFFYAQSGLQQFCSLYLNAEPLPEERNCNKSPWETLLSSNSPDRSHTSHQDKAVASRNDGWSRQGLFRFTFKILTLNTGAVLATKEACDHAFSHKTSNWGWAQFSSRDTVFYNNAEVQQSNAFLISVTITANPERPRPLTVGVSVPPALVEAMGSLLDDPDHSDVVFVIRRKRRHPATGVIVTRERRIYAIKKILASRCEYFRDMFDSGFLEADATASSSDDEMQDQPTFAPPSSRGLGQDQLGRPIGALASFSDEDDDDLALEDSDEELDADEVYEMGTWNLHEDARRDDILMARQGTALPPASSNDTSASRHQRETSSDVPQVWPTSAATVAPTPFMPSRKQPSQQNTPPQSRSRQNHDQDAGTDSGEDAARAPGMSAFQTPQHSPRELRNDGATDLSQLRDALPARAKLAAQPASRVPQRRRSDESTGASAPTGKKRRKVVVRDAAYATYKALLYYLYTDTVAFAPLHSHFYAQSAASTEDVDVPDDTLDSFGAPLNKPDRASSASDACASSESGDVSSRAPSTATGNSFAKDRRRAHVLRQQVIDEYCSTHVHVPAPCSAKSMYRLADKLQIPELKDRAQKELAKNLSVDNIVWEAFSGFNSQFPAIRKMETDFLLKHWSEVKGTEVMKSIFARPTAHPGLADVWPHLLSQLEFRGGSSGGKNDDKSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRQ4</accession>
    <name>W3VRQ4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRQ4"/>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="548" mass="60237" checksum="C5FAD488D9251AE7" modified="2014-03-19" version="1">MAGFGRMRRVAIIGGGPAGLSMADQLAAINARVPAFSVTLFERRTAFGGVWTYDADPGDCDVRFDRHGRAHALWGGRKDGDDSGRFCPPGPMYDGLRTNLPCDIMTYRSHPYPPQTPLFPSRATVEKYIVDFANTLEPIDMRLATAVKSVHRMSHDPAAASQSIGAGSKWAIQSIDTTTGKERDEEFDCVVLASGRCNTPSIPFVKGLWDFRGTVMHSAWWRSPVPFAGRTVLVVGNSSSGSDIARELAGYILRSLPEGDTATRNYMARCDHDPPRILHSYEKFDAPPPLDYDPRSTDSPDWAKRITVVPRIDHIEPTQAGGSKIVFEDGETRDDVDTIIFGTGYAYDFPYLDQEAAPFDSHPLIPRPPSTPPQQVGGEVYDPLFRTSSKLTNLDDWSLFYAADASICVLGAPIRIVPMPLTHVQARIVAAAWSGHIDPHPHSALPSLDPSIPSTDPDKWTSSSTAPKQGANSTTDLGYPSDTAYQNALLALLPKELAQKGDDEETQVPETQSNQPVLAKSEGWSIMPTFRNQRRQDTKRLRRLLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRU3</accession>
    <name>W3VRU3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRU3"/>
    <dbReference type="HOGENOM" id="CLU_005212_0_0_1"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="741"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1192"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1216" mass="134754" checksum="C056D9186C529376" modified="2014-03-19" version="1">MQANNLQLFWEIASSDQDARLASANQLVQQLLAQQDVLASTSKLTLNAALPTTDDDAANALQVDEAEADAVEDALGNRTVADLMYALRRLLRGLASPRESSRLGFAVVLTELLANIRYAVTAREILVLVLKYSNPQVAASRQEQKDFMFAKLFGIMCLVQAELLVQHTATIGEFKRCMRILITLSADKPWMAESCAWVMVNALAQIQQKDVAWAQEAHAWMSEQITATNELSPEKLAVLLQLSHTAPADYFHNIALPSMRKEHPLSTANLPQLARVLKEAIPAENDANATVGARSRWQPKIHFVWDLILDVYFADAAESRLAAFPDFYRVVVDETLFAASSSHDRKSWGFQVFERALARARDDDKPMLFTPNFMRTLINQLGNRERLLHRAAVKATHTIQEVVKHHPHLGFVLVTQLIGKNGHPNFDSITKTKTVEQVLAALDVERVREYVEHLGDIMCKGMATDDEDELQEITNRRKWALDQLLFLVRTPSVPKDDALILDVLTFLAAHGYFALTKPIKKRFLLHTLPTPPLADSLKQLTRQRFLSCVSELAKQAPTTIASATGKKTPGVAQDGELWLAKAHTILVQLEADKSVTSVFDHDAEIAAKLAEGVRCLERVRKLDAKSDSAEAHERSRAFRSLLLSALLVSADAADGASDLVEPLCACADKLFPPAANSSRKGRKGGEDEEEPTGIELLCDCLLSFLELSSAFLRTTATNAFEAFSQDMTKESMGLLLSHLRTTDEPASADEDEEDDEEMEAEDGEEEGKPSDTSATSDDESDGGSDADDDEEDEEVDEELRSRLRAVLKESGMAERDDGEADDDDDLDDEDDEDAQSDAGSESSVEFSDLGDDEMMLLDDKLAEVFRQRVSAVRDQKEAKQEAIALRFKVLELVEVFARKQPQSELMLDLIAPLYDLWKARDEDTEQLANKARGLLLTRISKAKTVPDSVDASQLRELVERMHREARESQSNDVSNVSQAINAYLTKTALSQAGDDAKTALGGELVAIYRASLLDYLMRKASRLRHEFLIDAFRRFPLLGWELRGELLDHCRPGAATRAFRQVQAMSMLQAVLTQMAQRAEKTEVLGFVPDISSVFVQIVTDSVEDSGAALTSSHMKDTIKFVLQAARISLRAEKDAGKVEAAWKVKKLQEAAEKLQGSERFKASASIHDLMKQLLKVVQPQAGDKVKNKKRAAADKDSASKSDAKSPAKKVKPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRW0</accession>
    <name>W3VRW0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRW0"/>
    <dbReference type="HOGENOM" id="CLU_052062_0_0_1"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="392" mass="42453" checksum="0DA4B318EA5FF525" modified="2014-03-19" version="1">MCARRRHVVTGTFNSPDLFVLEYDTLAQTLSILHQIRAEGPHQYLAYGESSSGGTVYATTWGSPSTLSAWHVTDDYGLSFGNHVPITATGSYVHVQPPPYASLTSPSFGSTPGLARWLGSAGGPTGELHRLDPETGRIGDKVHELVFLPGGAADLEKADKSRKALRYGAHSFDCSSTAADQVAFVADLGANAVQAYSFPDLEHLYTVPSAEDGDGPRHSIPHPHLPLLFTVTEHTNFVDVYRLPSARGQQPVHIARADMLTPSQAAHRHDFRGDTLRFSSDLRFLFATTRGMTPATKGLLVAYRLDVSDLDVKLTLVQRFETRTSGGKANAIELAPTPTEHDLLILTDDELGFMDILTFDPTSATFDVKATAQLPPLDDGKPQGASHAIWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS00</accession>
    <name>W3VS00_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS00"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="65"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="572" mass="62528" checksum="7BD931CDF2F9943E" modified="2014-03-19" version="1">MSGLQDAMGHAGRSDDAVHNGKLRSEEDGGSVDKTVHAAYADDGDELGVTTTEQAHLKRGLEQRHLSMIALAGSIGTGLFLSLSGSIQTGGPLGALLGYAVVGAIVCSVQFALGEVSALLPVSGSFVRHAAFLNDPAWGFAAGWNLVYGNVLSIPSEISAICVLFQYWTDINSSLWIMVFILLTFIVGVAFVRVFGEVEFAFASLKLLTVVFLIIFGLVVNLGGVPGVERVGFRYWQMPGPFVEFIGTGAWGRFLGFWSVMTNAVFSFAGIESLAMAAAETRNPGRTIPRACKRVFFRIVLFYLLAVLVVGMLVASDDPRLNDESGTAAQSPFVIAVSTAGYSAVGSVVNAIVITSAWSSSNQALLAGTRVLYGLALKRQAPSLFLRTTSWGIPIYCVLFFTAFMFLSFMTLSSGALTVFYWFVALTSAGVLVSWCTVLFNHIRLKTALRRQGIPASELPWNNGWTLYSSYAGLIMCLIILFTGGFRVFTKGNWDANSFVSSYLDIPLVIVFFLGWKLIKKTRWVRLDELPLRAIIEQAKDRAHQAEMEQQAEDALKGNRHRWLKYISWIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS31</accession>
    <name>W3VS31_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS31"/>
    <dbReference type="HOGENOM" id="CLU_043838_2_0_1"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36102" checksum="7DC14C370632FFAC" modified="2014-03-19" version="1">MRLIAVPLARARPSSHPISTFVAQTASRAAEKAAAAAAAKQQNDASRPPLSTRLLNKASAFWIDLGRTDQTSTFDWKRRTYVLGERLMDRIEYQEWALKGIDPAMGPLRHESKAKQADGAATDTGIPKLDHIPLLYPPSLLEPQRLLKSLKNLTDHRTPHHYRRFWYCVVGMPITIPFALVPVVPNLPFFYLVYRAFSHWKAYKSSQYLSTLISQDRVQPTESKELDEIFAQASPPPPTESSEASDKPQGAVVPKIQDDRMLFLPHHIPMLMERMEFPEWVRADLRRARLQVEKSAAENKLEELESNAEHEHPENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSG3</accession>
    <name>W3VSG3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxin-11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSG3"/>
    <dbReference type="HOGENOM" id="CLU_049216_0_0_1"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27697" checksum="63AC0B0A4AADAEC3" modified="2014-03-19" version="1">MSALQQIILHPYLSQLLRFWSTTVGRDKTYRTIQYAARFLAWYEYRKGATKETVARLTALKSQLGLSRKLMRVGKFLEHFQAALKATTIQDPVVSYAAIGRQLGYGFYLILDTLQWIHGAKVYTFEKATADKISKNAARFWLLGLTFSLASGSYKTYVLQQRAASAKRPRATAEKEADRKIELAQISTEQAAVRYQMTQDALDWLIPATGADILGLDEGILGLAGCASSIMGARTQWRAVNGSSAAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSI3</accession>
    <name>W3VSI3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000718_0_0_1"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="232"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="954"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="812"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1406"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="683"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="851"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1428"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1512"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1564"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1596"/>
            <end position="1605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1612" mass="175313" checksum="756567EB0FFD97A0" modified="2014-03-19" version="1">MDSIFGRKKRSRQFNSDAADKAIPYERTVSGRTPVHVDGALAASSSASSSAAAAYHSNASPNSSKLSIGNPSGNPGLGAGVHRSSAYSDANYHYEPSSASIISHANGSTVSSSGLGAHRRQLSGASSSRHGLSTHDSMHSSSSSFPGQNGARSSRYTSTTSASIAHDAASIRYNGGANHPHDVLTRMSVASTANPNPESAFPSTSTSHSSLGRDSYQPPVASSGGKAPDFVLQRPPDADVERLFAELMDKRDFLNVPGGNLSDELKETARRNMLGFSVDKKWTLVYNDKLTEWHAEKERDRNRRHHAAGAGPAGAASGLVITRNSPEWFIKKFMDGTVTTKHIESLAVTLRTCAIGWIQSFVEAKGTPVLASFLSGLHAKGIKSDNDLALEYEVLKAFRSLFNSKPGANDALAQPKCISGITHSMISLQLATRKQAADILLFLCHWDKPTGHRLVLKAFDDLKSTQGDHGRFDAWFRVLEQTIDGRGKMGSMVGASDEVKKLSVVGPHESSLNEYAINNMFLINAILNSDIVPEFEVRVHLRNQMEASGLQRILIKMRAFKNPDLDLQIGVFEKGAEADHEDVVETFNKEVLTDLSDPVDVFRAIVGKVEGSRAYDFFLSALQHLLLIRRDGDDLVHYYQLIDSMVTSVVMDRKGAVEGNDLSSLLGVSVNNVLSRFADQDHINSMQSELQKAKAKATALEQEKLELEAKLKQSSDGLIGKLQEQIEKLEDDLSLARGNAGAARDEMDEMEKAYIDRVVALEIQIRELYDMLREAQMDVSDVAAPGKGSLDRKQLVDTLEKQLERNKTIRKLEANARKNKPGVPSVPPVPGVPGVPTEDDRKRISASVRPAMPPPPPPPPPPPPAPGMRSAFSTPESSRPGSMLASVGGTPAPPAPPPPGSVHESPMQDGLFRNSMMNVRASYAPMNLGPAGPVAAPPAPGVAGLFVNHALSRKEVLAMARSKMKQLQWDKLSAQHAAETIFGQHELTADEEQIVRQLQQEGLFDEMEEDFKAKQPVKKSAAMAKKDKMELKTHLSLQTRQGIEMVLKRVKSSLTESKQASPEEVAHHIINCNDAVLDQSFLTELLRHYPESETKGQLGEYRNASDEELRLLHPADRLVVLLMTVPHLKEKVKGLLYMTRYKETFDLIKGGTVKVRDASEGLMKAKSFARLLSLVLMMGNYLNSTGVQGGAFGFKITSINKLVDTKASDGTTLLHFIERTISRCFPEVEAFMDELELPAEACRVQLWDLRRDLAELKSGSFQHRKELDRLLDEDEENLQDPYVKIMLPFLNDAASELQRLNDQVQFAERVYSEALKYFGEGPDPKKRGLGQLANQTMRTEDFFGIFKEFLAAYKKVKLDNVRIGEQRALEAKRRAAAEERERERQEALARKEAGVDDSAVLETLLGSLRSGGGGPNKQRRKARERRQTNAASNAGGSEDSTLGSGPGVAGEKGNPSDVAAAMLAKLQGGEEGGEVATSSAFRPTRRRDRRSGRDAPLPPGSAGLEQGSPAMSSPSLSQTASSSTHTPSASISASTTVRADASADTTIVPPPLAADAKEEKDKEWEEEEGEAEFEDALPAHAPGGGGELEWFDPDTSGFSAAGKSSASHEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSJ6</accession>
    <name>W3VSJ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000796_0_0_1"/>
    <dbReference type="OrthoDB" id="423221at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="2195"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1854"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2376"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1874"/>
            <end position="1884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2409" mass="266003" checksum="54811ECD58832170" modified="2014-03-19" version="1">MVGAKRNTPKRAAAAGEAGQARISSFFGKSPARTASPTKAAASPSTRTTKKLKQGNSKHNLVFLGVSDDESDSEDENENTSSADEFKPENHASTDDDDGDNGHDNDDDDDDAGASVERSQSPSSSMPETPADEDPAVVGYHYGTNPFVMIGGGNKTPLRPISNLPSSSSQRSLRSNGPPSTQKRLFSLFEKPSARPKRTADELDDLDASFLDDDDDDDDDAKPRKRTGAAARRTGAAVPSFSSGKGWKSSFALKQPFRKMPFVPSPAEIAQLRETMKEKAAENLYPPIHDLADIFGDMVKRAPAILELAQTLDGRPLRVATMCSGTESPLLALELMCRAIHEQHGIRINVHHVFSCEIEPFKQAYIERNFSPPILFRDVTELGGEKAHTAYGALVDVPGDVDILIAGTSCVDYSHLNNSKKGLNDGGESGRTFRGMLEWVMRHKPTLVVLENVKNAPWVGVAETIVAEAGYDVGFSNTFDTKNYYIPHTRQRGYLLATRNNRDSLPQNWDLITNVLMRPASSPLDAFLLSTDDPRIQRVRRQFAHGEGLSKGRSTIDWSKCQSRHERARDEEELGKTRPLTAWEEGGTCKMSHDGWNEWAVRQPERVTDLLDITTLRFAAMGQDPIYKSKIWELSQNVDRNVAASRPGIAPCLTPSGIPFLTSRGGPLIGLEALSLQGLPLDELLLTRETDDQLQDLAGNAMSSTVVGACVLAALLVGMKDLKEDGEKRKAALASTSTKEKRQDKLKDASQVVEKVVDERESAIAHADLLAPQPLDLTSSTLVSMPELLGAAVNTAQLCNCEGRSRVVDVPVYRCTDCDHTACETCKGRPVHKFVLDTLVRSSPDDFAPMLKAALPMRLEASGLTRQICSSLMQGLQFQDDAVAKRWCKRVVDVLETAEFRFQSLLRQKVWQAQFSAPGARLDLLLDPVEPHWRILVEPDVDEPAGSPLRKLLIQPVARMPLDRTAEHVDLLHGQWELCVPSAHVATATIRSTGKQVPTWQSAMGLGGKFADKLRYSEMHVSVPDSVRELLDAGIDGAYDLLEQCGTACGALHVRRGEQKEAARRRLFLFIDTDRFQDQAADRFVFSTDTSRWPYPLERVSVAQLEPGWRPKLAHADQEDVEEEVKLTIAGTWRKVDAFNVRAGKGVDGTMAIPETTYDLDLRSEDCTSSVAVLTCEAPVKDRGMDRIWPADGVWGQVDLLHKTNTTFGHLAWLVERLPDIDAFDTWMSAKHDSFDCATANCARCAPSEPDIQWLAVPGKPVVPVENTMQAGPYEQALKNRPSPFVVQLRLDDGRAQVRFGLNAATLMHRAVSRLPPSKGAGTVELSWRLTKLDRAIDMFKLPSYTLRSNRQDAEAPTPELFRVELRREQKRSLTWMLEQEQADVEPFCEEEIAEGLLEPLGWRAEGRAVRNMTVRGGVLADAVGYGKTCISLALIASSPHRRDLPALPAGEEGSYVPTRATLIIVPGHLCKQWEKEVRKFCGSKLSVCVVTSKAELNKLTVRTVLNCDILIMSVTVYKSDAYWETLAHIAAANPLPNRAGRFFNAALKKSLEALKNRVRELTGHEEEGEGIRKLVRSIKNRVDFDDSHLTTHKARSRLKGKAYMDAKAADDGEDDDDDVVVVGAKKGVKGKALPKELQTSGKKDPDPWGLTTSLVQRDWHNMKCPPLEMFMWNRVIVDEFHYIGETMDRTLAGVTSLQARSKWILSGTPPTADFADVKSIAVFLNVHLGVDDDADTTKDSVRKAREKMRTAAEKFNNFCEMHSPAWHHRRQQVAQRFLDRFVRSNEPEIGELPCAHLIKPIRLPAAESALYLELAHAIENLDLRHQRKVFKARPKTKAKVAAKGKAGDDFIVDLDSDDSDGGKKKKKAAAPAKRKEGEPQLEMSHRDQRLIDTLGSSASPEEALLKRASVYDDFAGVDLDAMEGVNNAIKACEYIVRERRKQLADCREQLKRELPVALEQHLLVLHHFGYRDENRQAFADFVRNAHNAAWGDRESKQMVRELLDAANCTQASVSRAAAKAHFAAPGVLQAALKRRAKERAAAEKGSGGGGDDEGKKAKVDAKAAAWAEEYHLRALVHQLTRLRNELVGRVNALRFFSMIRDCQRAHLEGVHVEVVCPAAKCAHAGASLPLDEVSISSTCGHTGCSTCVLREAYIGKCTTDGCAALAKPTSIVHASSLGAEDDGKATRYGTKLALLGALLRRLPADERALVFCQFETLTATVAEALSAYGISFVQLTGTARKRSELLEAYQQETGARVLLLNVEDESAAGSNLTVANHVVFVGPLLKQEQQQYDATMTQAIGRCVRYGQLKKVHVWRLVSMQTIDQDTLERRERKQIVQRADVDGNEAEDTLVVEELEQQFADALGGPLVIQDVAAGVGKRKREEETVGRRKRPAKRVVDSDDDDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSM0</accession>
    <name>W3VSM0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSM0"/>
    <dbReference type="HOGENOM" id="CLU_1195312_0_0_1"/>
    <dbReference type="OrthoDB" id="10424389at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="232" mass="25963" checksum="A6A9809EFEB713C0" modified="2014-03-19" version="1">MEKVKQHEVLLTTNICLVGILLWILCSYIGALLAVLAVLFLLFPEVRRGILATPQQDKSRPRSAWLDRQKHGEHTIRKRTRAEFNYRGGIARSGHTKAGLSPHARNAGRGPKRFNEFSPEETLALPPRLELRFHLRPYGADGSCSSDRPGSSGYFYDYATSSEDVCSNMLQVAQCPAEASSHRRPPKGEERARIVAWLQGVAQEMPSGWLPRTAPDFPLRRHKTLPQSGPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSS6</accession>
    <name>W3VSS6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSS6"/>
    <dbReference type="HOGENOM" id="CLU_671161_0_0_1"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="373" mass="39989" checksum="986F8F9E1FC90800" modified="2014-03-19" version="1">MPSARRSSQAATASASASASAPSTEAGPSSIPATSSMSKASAAAAAAAADKKEEASTDAHLELLTEHFGYNPKSFIDALVYLSNEHLYSIATEFENVVGGLLDSVDGGELEAEQGIHAILTLMENALDHTMDTFELYCFRSVFGIRPRQAKYMTLDHHRGLDLRPQQPTAEDKARSKGGRKSAVASANSASERSYKLGETEDSLKRQIAAARATQHKLLLAQAASEQTLSRMLSLSERFSSILARTDSAPLLSETLGQYARKLRADTAPLLRSVGELRAADPLGAPLHSSTAVEADDDEGAATDVRAWQRGREGYLNWEADRIIAKSKRKDAPATATVPVVEKEADEKTPKKKRIAAATPASKRRTPASTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT44</accession>
    <name>W3VT44_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT44"/>
    <dbReference type="HOGENOM" id="CLU_771886_0_0_1"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="279"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="359" mass="37701" checksum="052E65DE32CA1E20" modified="2014-03-19" version="1">MSHGSTPQHGQTLQRATHYVDRDDPGPTFDRSGSCRGAERRRSRSPGAPAHSGSSVPWADQRLPRADAAPPAKPPATSKGASVKPSIPRPAATAATKRMATDITKWNRKQAELHQLPASSPATAAVSDSAEAGPSSERMSSAAEMSSEALARYDYKDLGRIACLLCQRKFKSADTLHRHESESQLHRDNLASADTCRQGVARKLEALASLTSPADNATAVTAACSAPTQYRDRASERRAVFGTEAPPPSAASGAGKAFDAPKTAGGETVRSAPERPVGEENVGSKLLKMMGWTQGEGLGKGRQGTTEIVQTKVYRPGAGLGSAAPVPTAERPGGAESIATSSRGSVTFQGYAHRARDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT62</accession>
    <name>W3VT62_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00639</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_3_0_1"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000003">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000006">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000235">
        <property type="entry name" value="Probable nik-1 protein (Os-1p protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="327"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="419"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="511"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="603"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="695"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="787"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="861"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1229"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1358" mass="147725" checksum="B68E669FE3131867" modified="2014-03-19" version="1">MATTLNGASPSPVTAAFMSRTTSSPLPDLASLPSDFLDHLLLITQTLVNSKPPPAVLRAMSRDPTRKTENGAHSHFNGHDLADDVASIDLDEPNNTLDGTVSLPLPHFTSAHSDERTRAIEENIGRLAARLWQAEDHLEVVARSQEIVRTPGAEEDSAQQSPKDPRNLFFGKPFPYPLSHAQPQSSNYPLSYPLGMGLNGPVLLGGQVSRTDDPIASFERYNDESGLSAQEELRLLKAQVQDIARVCKAVAFGDLTQHITVPVQGHVMVELKDIINQMVDRLSHFAAEVTRVSLEVGTQGKLGGQAEVHGVEGTWKELKDVVNRLAANLTNQVRGVALVTKAVARGDLSQKIEVEADGEILELKVTINVMVDQLRHFSTEVTRVSREVGSKGQLGGQANVPGVQGVWKELTDNVNRMCSNLTGQVRSIGVVTTAVAKGDLTKTIDIDAEGEMAQLKDTVNSMVGQLRIFASEVIRMSMEVGTYGKLGGQAHVPNVEGTWKDLTENVNKMADNLTSQVREIARVTKCVAEGVLTEFINVDVKGEILDLKLTVNNMVRQLKTLSDEIIRVSVEVGTEGRLGGQAKVNDVKGQWQVLTERVNMMASNLTTQVRSIATVTTAVARGDLSKTINVEVRGEFLDLKLTVNNMVESLRTFSFEVTRVAKEVGTEGKLGGRATVLGVGGTWKDLTDSVNTMAANLTLQVRAIAHATTAVARGDLTQKVTIPVSGEMLDLVNTINNMIDQLSFFASEVTRVAREVGTEGKLGVQAQKKDIEGTWGEITDNVNIMANNLTSQVRAFAQITAAATDGDFTRFVTVEASGEMDSLKTKINQMVYSLRDSIQKNTAAREAAELANRSKSEFLANMSHEIRTPMNGIIGMTALTLETELSRSQRENLVTVSTLAGNLLAIIDDILDISKIEAGRMNVEEIPFSLRGIVFSVLKTLSVRATQKKLNLMYEVAPDCPDPLIGDALRLKQIITNLIGNAVKFTDAGGRVALKCKLSKMINGNLAMLEFCASDSGIGIKQDKLDVIFDTFCQADGSTTRKYGGTGLGLSISRRLVNLMGGDLWVRSNYGKGSDFFFTMVVKLDKISPDQVKEKIRPYAGRNIFYLDTLHDRTGVQAMIEDLGLKPFTVHSVDEASHRKRGMPRIDAIIADSLAVVEDLRNVEHLRYIPINLVSPAQLTLNLTYCLDHGISSYINTPTSTADLYYALLPSLESSAATPTEGSNEVTYDILLAEDNVVNQKLACKILTNQGHKVDVVDNGHLAVMAVKKRQYDVILMDVSMPVMGGIEATMAIREFEKTLGDEQVPIVALTAHAMLGDKEKCLQAGMSAYVSKPIRRVELISTLHSLLSQKKSVGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT76</accession>
    <name>W3VT76_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT76"/>
    <dbReference type="HOGENOM" id="CLU_1482610_0_0_1"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19859" checksum="99449627B0E8B073" modified="2014-03-19" version="1">MESTKVPVKLARPSSSSSRSSIRHAVAAAAAAASSISIDTYSTINSYFADSSDAGIRANMGGNFVFAGHTRKPGVSAFDIRTDDPNLYICLRPDTFNCIAAVLHIATSLLDMLLRRRTTCRSSTELVTKVLGRTGSRGGIIQVRVEFMDETRRSIIRNVKGPVKVDDILALLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTD8</accession>
    <name>W3VTD8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SEC4-like Rab/GTPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTD8"/>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22929" checksum="10B56B67DE2D1C1B" modified="2014-03-19" version="1">MPNPHYDFLIKLLLIGDSGVGKSCLLLRFCDDAWTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVFDVTDQKSFENVRTWHANIEQHASEGVSKILIGNKSDWEEKRAVSTEQGEELARELGIPYIETSAKSNANVEEAFFNLAREVKTRLIDTAAVTQASPAAAAGNVNVNSAPKSGGATGGCCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTL9</accession>
    <name>W3VTL9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001071_0_0_1"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="874"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="874"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2332" mass="251055" checksum="CF403D20EEA59FEA" modified="2014-03-19" version="1">MPALPAASTSPGAAGIAVFEPARFERLHRIINEAASNPVRLARSNDWFVTIDRNRSDLADLGRVRPSSDLERKEIESGKITINGSTQNLNPDFAQQSLLLARELGVSEHFAASLLQQGIAGRAKWGRPAVEVACILHHRERLALLACLKELLRNALTMPFEDDVEAQRMGLKMEQLVESLVSIETSVSSPGSSTRKVTLAERILVEIDNVKASAARVKASLESPQANQAIQTQTSNFLGLGTAQSAANNNNNTASASTSAQGRLSDEIQLDRRAWLREERRELGHLLYLLSISSLLTPSNISAILRWLAAVSAETYDEMTIYVLTALLGALDANPEARAAMAERASRGTLRKTVEDLLDDESFITSTHAEVTRKKWALGELNSAVALQWSLFLVEAFSRNPTYRSQLSISDEQIQDIVLQSITGSSLSKDSKQASGASSATEGPSGGAFIFLVVRILAFRQKTIDALFGEEEGAIAAEADAAAAVAAADLMENNAWDDEVDAEFREYVVQQIHNLAVGTTSVMLPMLRRIQRSEEDAAFALSRGLAARAGGSAPPERRYDIEALFDLIALLCRGRSEAGLPFWVGPDNRTTRFLTWAIDVREPGHQRALLNMLSAMSSGPQSASQAYALLDQESGSNGAAGEGRLVSWSRFFEWITYYIDTFHQAVSSSSFHSSSYQTLAMPKNEETLLVGFLRLFRNVIFFSQPARDALLQNSTYNALDKLFSLLTCPVPVELKASILDALSAFLHHGSSGPTARARFSAIATQLWDRFDECGLLPTDGAANKSRLGAEQTPSTAFGPSFKPLASKGVLYELENFEVPLRTFPGSTSFVNFLKALVQLPSSALAAGSSALADNSSVPTTGANPFNTIVEYGQSGQQTSHSQGPSSYQQQPQQSQQQHNQRRHLRSVERYVDFVIDHVFLKARTRDYVEPAEQWRVVAACLDFVDRSLRSYDLAALLRTSEGAEAVADPSLLTTLASHPGFFLMRRILTGSKMVGEMLGILVPGSGLAAFEAINQNRASTFFYGSSVRHVLSILDRVLRYQDLFVQVLLPTLVDSSLNGVQLPFDVSARVGNSGSYSSFDIQLLHAHESVVQIALLINCVRDDVALLSVRLLGLIARTAAFSAVDRFGEMGYRRKMNRLVGLLEMSDEAGRVKAGYVGRLEAEPSGDAAGAKLLEALTALAGNADYDQDDDADLVSSDVSASAALGSGDAVEAIQIAIVNLLLAGTEASQPAPNVAHLLLGYDLRAVRPEEQVIVDPDANTAAPSAIHAILALLRPEVDGEGSTFLSLAERSPGFAEKCCALLLRLCTHPFTSAATLRYLRTKEDFVVQQLRSLPLVPAERPTLTDDSTAALGLVQFADGQNIETTVDRVTASLRMRASLLELTALELHSLLNANMQSRAARVVAALFGSNATVGGVDADDSVDEDDALLGTERDFRLGAGGAEVRTFGGVRFLEILQSLDFEWYDDREALGQGITVINPEQLELAKRPDAALGPRLYDLGAVLAVLVREKTLLQQKGSLRDAGQANPFLEQAAFVLQWAAAQNAKKAVAFSRRRVLQAWRQTLDMVLARAAGLLRTEARSGLMFDCLSELLPRISAPSNDAAGLDVPSADLVAGAVLSLLTSLRQHRVELTTGALDLETVDALPVDRLLTTLRALVDSVLRIETTTLARGNLYSALINFLQLVKSGNGNEAGVDAGANDGASIIATDVDESMSVGGVSTTTTNIFGGRAQTSTLEARTRTLLLSHAERLMDVLARDALDASDLSKTIAFTLLDKLCALDAPASASGSSRRGGSRCLDLLDRKGYIKSFVTALRDSDLALQETLRPDPASLNAIYVYEARLAFLNRMAQTRDGAERLLSAKIFDVLAQSDYLAARPDQDQEFVDLDSFLPAATERYNALLTPVLQLTTSILASASATGAVSSHGAFGGPKGLAATSASAAPRHALALLTAHRDALLTVLRAPLQEFCSYAQLGQAHLVVAIFVLMMPALDDDAQQAPSPLAPFHTAIVALAATYLPTSAWRSRIVPYNEAEREEARVRTASLRALPGVGEANGGVGVEEESAFEAKVGAMVVRMQMALLSYLEGASDARGNAAARVRAVLIPSMAAYRERSRTPYGVDDGADGDSSRAGLLRSQRASAAASTVPSLGSLVAALDEYADSIAKELQALENIETLLENMDAVRQDELDEIARDALGDAGVGELSPAQRRSVALRHLRTRKASLRAASTSKLDAVELILVLLIRHIDFFRTLTTDRSTAAGLARSSPVPSLLGAAANNLDRSNLMQALAESLLPIVEDKIGYLSLPPALVANARERQSFLQMAGRRLANFFTDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU75</accession>
    <name>W3VU75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_01177</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU75"/>
    <dbReference type="HOGENOM" id="CLU_004624_6_2_1"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="399"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="873"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS64331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="897" mass="98073" checksum="2E82EB831307F8D1" modified="2014-03-19" version="1">MSGRRQRGSTAGESYELPASPPSVAVEEPLLVNTSFATDPDATDASLQRLASPKWSRSNSRYSAFDEGLEPDSEGRFLSAAAAYQFDPALSHGHSTPMQERPFTPPFARSDSRPTSLASSHMLSVRSRSDYDSVYQLWRQSGTPSSFRDFADDAASSHYDRRGSQARDLEKIEQYRAGAYDPPSPPTRNAAFQGLHQGEAGAKGPKDYRAVGLAKYGRGKDQRMSARKKWCIVLAVAAVIAICVVAVVVPITQVLLKDKSSDRQANTNGSSSNSGSGAGTGANPAPAPEKVVATWGVNGSVIDLGNGNNFTYINNFGGRWASQPLNNSAQAQNYTPPLDQEFDFARNRILGVNLGGWLVTEPFIVPALYEPYENTSNPAVDEFTLSQRYLSEGGADNLRAKMTEHYETFITEQDFANIAAAGLNWVRLPIGFWALETYSNEPFLEGVAWNYVLKAIQWARKYGLRINLDLHAVPGSQNAYNHSGRVGFINYLQGLMGKANGQRTLDYIRQIAQFISQPEIRNVVPMFSVINEPYAISIGQPALQSWYSEVYSILRSIAGTGAGNGPYMTIHDGFLPLSSWSGFLGGGDRVAWDTHPYLCFGQQNNDPWDVQILKPCQQFTGLLDNARSNMGVSMGGEMSLAINDCGLFLNGVRDGHRYDGSYTGPTPGNFPYVGSCQPFDDWENYSDEMKRGLRRFALTSMGSLRDFFFWTWKTGNSLRTGKPTSPMWSYSLGLQQGWMPTNPLAESSGACAAQASRLGTGVPSATWGSAFQNWQTGRASSYSPNTAAYPWPPQSLVSANRPVSQLPSYTPTMSITPVPKPTFSVTATVSGDPTPSPTIGAWYNTDDTTPLYTRIAGCEYPSDQYDLGSWNPSGWPCSGGQQRRDEQPRALPTNPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUF1</accession>
    <name>W3VUF1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUF1"/>
    <dbReference type="HOGENOM" id="CLU_1082477_0_0_1"/>
    <dbReference type="OrthoDB" id="2552165at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="229" mass="25118" checksum="C2C0589B269399EC" modified="2014-03-19" version="1">MTGIPITAGGAGTDYERTFKKHFGDRPTAFALSEHARASTSAQPLGEDAVCGSTNSNTVRAGRVDEETHSKLQNLGYRIRARVNQGYNRTTTSLDPFGSSEGQILSNVTNTRRAWSRVQSAPASKDFDTLKSLRSHTDTHNVTQGAKRSRDDSDEEPERTESNFDRRIAAMPALSFASTASSNSSLGDPPQTSWTRSHSSTQPFAIQDTDMPDSKLEYDFSTHFNSTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUG4</accession>
    <name>W3VUG4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3',5'-cyclic-nucleotide phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUG4"/>
    <dbReference type="HOGENOM" id="CLU_396436_0_0_1"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024225">
        <property type="entry name" value="cAMP-PdiesteraseII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00607">
        <property type="entry name" value="PDEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0114">cAMP</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="79491" checksum="7D09C7364714D6B2" modified="2014-03-19" version="1">MAAPFSSLRHDTAVASSSSQLNAPADAADNANAPSASRSSSRNAYRRSSVYSDQSFYSAPDYRRRRQPRVALHPPDVPASFSFVCLGTGGGPLEGDCSCYLLKPADAQWQDGSIVVEGGSWLGALTDVLEQHGPDSAFHDFDFPATTPSAFLRAGLMASFSTAFLISHAHLDHILGLVLGSASLPGKRAVFGLKPTLENILDMFNGKIWPKLASWNEDEPHTMYHMRSLDNQRPFGVSDALSVLPFALSHGLNPSEPPAPPTPTYAPTQLNQNYFSKRMSLPISTQMASFQLSRGGGGGGGADDRTRTLESIAQGGESNLAALRRPSFNNSPFFAPNSTQRDRLSNGSLNPLDASPGKHNEPVSPRASPAAAPAATAATAAPSSSSSSGSLSSVAMLPSVSSGPGIPTRSNAPLSEAQALAPQQFGAKLPERPAKGRRPRTAQGSERRSSPPSAWSPAASANPGGAAAPPPTRQPPRRVSIDRSPPPLDSTAFFITHKAHDKDVLFFGDVEPDCVSKSPRNRQVWSHAAERFAEGKLNAIFLECSFPRGHPTEFLYGHLSVEHLFDELRVLAQMVKRYRQKMRRPSNASGRSTGAHSSGGGGGGGGSTAGAAKAHGEGRYTPHLAPSPLGTAAVSTDEGDAREAVGATGSHVYDGDAELRGQLDGLGVIVIHVKPALFPTFVQDDAQPASPTSAASGSSSMEAAAHGDDSDAAAQPQLDPRTAPQKILDELQHEEHLAGLGVRFVMAEKGMRIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUM7</accession>
    <name>W3VUM7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUM7"/>
    <dbReference type="HOGENOM" id="CLU_007727_7_6_1"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48252">
        <property type="entry name" value="HISTONE DEACETYLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48252:SF77">
        <property type="entry name" value="HISTONE DEACETYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="100"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="274"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="534" mass="57349" checksum="D40E29795AF939FF" modified="2014-03-19" version="1">MAVVLDPPRVAYVVSGDLVRYADLLPSNKGRSSHVHSLVHHLDLLDLSTLDDGSDEADVDTHKRCKSAGSSERERFLAAIGADVSTASPSKSDRRRAAVYLPHPATRQQLTTFHGESFVDHLTKGQHAQAGVSQPPRKRQRVVSDAGTSDSDSNTGSDSDVSRTSHGKRTAWVKNQFGLQDDCPTFDGLKKHVSLIAGASITAADLLATGQADIAIAWDGGRHHAKKHAASGFCYINDAVLAILALRKPRKVFVTTTVPRGSGDEATVRKTTIKRVQRVLYLDLDLHWGDGVEEAFHTSASVLTLSIHHYAPGFFPCYTASSDSRYGAPGSLGADPGAAGTTINIPLAMGTSDASLERVMEATVEPVVEAWQPEMVVVQCGVDGLAADPMAVWNLSAAAYVTAIQRVLGWKKPTLLLGGGGYDTANAARCWSLITAAALGRYEDTTKRRAAAPSFEPHTLVDRESVEAKPDDNVQTQSISLETGVPDHAFWPAYAPHYTLNVPAGEMIDHNPPAYFDEIHTCLSARIESFTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUN1</accession>
    <name>W3VUN1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUN1"/>
    <dbReference type="HOGENOM" id="CLU_344873_0_0_1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="639"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="662"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="818" mass="87493" checksum="8BC92B856BDEA81A" modified="2014-03-19" version="1">MLPGGSSGMSRPHSTYASGPWGAVSDQHQHKPSSHPSHPHLAHSAYSVTAGPSTYRALSSGHIAPISPPQHSHRPDAWAHRPSAGPSPSSPLPPTYAASAPAPASPAEQPIIRTTHVTADGTTIYAATGRKRKRLQKACVACHKAKRRCDGGLPCSNCDFSGRTCCYSDANGKMVIPTARVANEAAPAGAVMPASAHSGATLHPSDGRSPSYNAAAAAPSPSSSDVSGRVRANTVSSKSSPMSIGNTGARMEALFTIDDVAPERRRELISIFFSQMHPFSCVMDEISFLRDLSTSEVPAWLLMAMFALAARFEQGISEAERERRFSHGEVFARTARRMLSEEDHEGYTLLDRPDVELALTLCFLAAHELGMGRLQRALSYSNDAVRMIATLRLAEGHLPAARKANYGRDAFSSSSSSWPRRAMCERLVLLSWTLDMTIAALAGQTSTVRRADVLAAARTFGSSGDETRDDVTKSFARLAEIITVFGLVIDSNESSTLGEDALQSWAAALVVEHKFDDYNMKQASRLLEEPEASAASHRAWFWAQMHLVAECSVFLMEARRAGAPQPDRGQQKAAVDNIHLILSVLSITGRRNLFAFPALLICTQYSRPSPDASRWWATARQCWNMAEHQISEAARFFVRPSNDAPSPGRARSSSNVESLTLPRLSSSSAGGASARSPAPLPSIGRLPLPSLRLSPPLSASSAHSEQHRSPKQSSSGAAALPSWRSRSPRSSIGGKSDGDAAEQDAASSNGGSSRDSSSISPRSAPMELGGEEYVPVIANRGSRSPPLAAHAFTKDPRTSWSPITSLRGEKRTISAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUN5</accession>
    <name>W3VUN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in 20S proteasome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 20S proteasome chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUN5"/>
    <dbReference type="HOGENOM" id="CLU_062640_2_1_1"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="246" mass="25899" checksum="34143CAF8C8BEBA5" modified="2014-03-19" version="1">MSTPFYTPLASVLPSFEGATLLIPAVSIGSVPQLAVDLLLHSADLGLAKVGRIDPSFCFPFAGPSDARDAAADDITTALEVFANEAGLVVIQQRAPVYKSRGTEYITALTKWISQAGFKQTLWISSIDAAARTDAEFETPILSIPPANPQTPLMKALATFPVFAPAGETIPVIPGSLLTRKLLQLDAELNLGTLLYFAAEGDTRPDANSLATTLLSLLSLPSSAPLQEPASWSALFGAPPNSSLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUR6</accession>
    <name>W3VUR6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-nitrophenylphosphatase</fullName>
            <ecNumber evidence="3">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUR6"/>
    <dbReference type="HOGENOM" id="CLU_400184_0_0_1"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="6">
        <location>
            <begin position="131"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS65363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="678" mass="73790" checksum="D14ED4C42B57A0B3" modified="2014-03-19" version="1">MSRFLGRLSRTPSTHSIKSNQSDANGEPLPPKTSQILTTPAPGCVPKPRDPLTPEQEAKLAELEKYARSVASQTAPPADYEVWEQKWLGEHNLYQRYLRAAKGDVENAKKRIKSTLEWRREFRPEIIAPASIAHEAETGKQIVSGFDKDGRPLIYLRPARENTTPSNDQVRYLVYTLERAIDLMPEGVENYAIVIDYRGATSQSNPSLSTARAVANILQNHYVERLGRAFVMNVPWFLNAFFTAITPFLDPITKEKIRFNANLAEFVPAEQLDVEFGGRYNYEWDFDVYWKTLTEQCGIAEDGSRKQAGAKPAAVDKHADAIAATQLTGDGATVGLGAAAGTTAALAVAAGSTGAVSANGAKTTAYKYLQELADYEELLGKYDTFLFDCDGVLWSGDETIAGVVSVLQKLRARGKSVIFVTNNASKSRATYLKKFAGMNIEASLDEVFSSSYASAVYLKKVLNFPADRKVYVIGMHGIEEELDAEGILHCGGTDEEDNKFLPALDFTSLQNDEAIDPKVGAVVCGFDMHMSYIKIAKAFKHLTRAGCEGDVEAGKEGGGCHFILTNDDSTFPAKGGPWPGAGSLSAPLVFSTKRTPTIVGKPHKPMLDCIIATKQFDPARAIMVGDRLNTDIEFAKAGGIASMLVLTGISTRDEIEGDDAKTVPDYLINSLGDLDAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV03</accession>
    <name>W3VV03_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238367_0_0_1"/>
    <dbReference type="OrthoDB" id="2552706at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="2">
        <location>
            <begin position="554"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1716"/>
            <end position="1737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1790" mass="191560" checksum="7B3B0862AD40E878" modified="2014-03-19" version="1">MSDAKPVRLDCDLFEPPPDDEPAKTAVDPNEPPLPNSNDQPPAVQTVEQLEGKTDGSPIKAAQGEEQAIAAPTPRRMTNKQAFSLFVPPPPPPATQTSTASATANTSAPAAPTNAPPPAPTSVPSAPSGTAAWGGHLAACQRDQDLRLFLAGGDGKIAEYVSATSPDGGSASIDMAAGTLNTTCLAFSRIAATTFAGNKILIAYQNAGGDICQRILAASGQTWNDEEVVIPARDQPLAGTTLALYETADGAVLFWQNANGGLVRKLLDGEDTVCPLDIKGETPLPGFHVHVNYEGDDQPLTIYWQSDKDSVIYGLRGSPSAHNVGFTSAAQLKMAHLTSAFAVVETPVIADTKSGGPVFYYSNSKRRCVESITQGEINAILTPAAAHIDPNFGICRLRPARRAADDAKATKLLCISDDTSFCMLIVRDAVDLDDDKTKLVQIHLSNAASTPSGNGQQPADNSGTNSGANSGTNSGGQPSGGNSNQSSGQDPQKPADDQNVDAKPNNMASVTSWIHKTCKEVLTPDNLQTAVTQGIQIAKKLTSSSRSDTVFANAEKLWEGGSPQTIYYGFLPGEFAGNDIQQGKVRSVIDEWTWYANVRFVEGKSIGACDVRIRFNPKDGSWSYVGQDCHTIQPQDATMNLAWVLPSGAVATQNERAVILHEFGHVLGLLHEHQSPAHGGTAVVNVQAALDMYRTGQHWPDQQIYDQVINVYKMKDVSNFSEVDTKSIMHYPQPKELTGLKQDIGYNKELSDLDKAYMVLQYPRDTPHAQAAQWTFDYALSKINCPESVCQQMRAARAAIKDSNGKTDLSKLRKILGDWSIAAHSKNTGASPAHDVDMEPSSGATPASGVVFAGDGGAIPSSAADPAQPLHDGAPPTGEAKFDSEGPFIKVMYDKLMNFFPPGDGQYFALQFPTRYLDKASFAYDTSSVFSRFEKPVVVNEAEFRLTDELYNLGPIVGGPNGQSLSNNYVKVLDSLVPSYEGIEARKQRELMRSWLLAETHPDEAAFISDSRLVVPNLNGSAVSQLADGSGVQISTNGTADQVLPDQGGASTDASLNAAKGALRGVEATGMTDARLMTRMEFSNTLTMEYLGAKQKWELDRDAQMQEAEAKNDPKEMEKLTRKLAHITGTQNAILSNKYANAVVRGHTHTVRELLGHLDIRTTAEMLQDAKDALRESALSSLYTASSVYPVQMEPTDWFQALDTGFTTEDLSQTPELMEQAIESKSKQIESLETRIATLRGFQVGDPKDAQKAVDDAAKKHMEAMGALSKAYTENTISAVKLAITIAGAVTPAGAATELVSSAWTATKGNIAGNSTAKSKLTGIFGDDLKGLDDIGTQITGVTALNMEVNAASRALTDAMAFAALAKAGDTHTEVENTQRALTAAKDELQDLQDHYGMALKAKQVRDDDKTKPTEDVGKLPAGNGGSRWIDLSVSSLVKNNEKSSVATSSATTSSFSCNFWLGSVSKSSSNQAASVIAKQKEYSLKVTVNMRVTYVTVDRSGWFDPSIAQMSGAFMHLYQGSDYASWSTWTDGVNSTTMAAEVSQGNTSHIKEGYLSVFPVGYVLVKDCVIQVQSDDFKSDEDRSSFKENSSTSGGFLCFSTSSSSSKTGDSSHSSSTQTSDGMVIRIPGPQILGYMMQLVHPDKSREFVKMPTDYLFEEMQRIDSEDKNRGGASGGGSGPAHGINPDQIPDQTDRKPGVRRFNASGMFRDGDNKPAAATSSSQGSQSGPSVGPASSIDPNAGNGTFASNQSYADQVKTLFLNNPALKDRTPEDRQNLYAAFEKALEQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV58</accession>
    <name>W3VV58_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV58"/>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="512" mass="54769" checksum="B57B33ADFBB27707" modified="2014-03-19" version="1">MAIAETLKIASPSGKTLSVPTGLLIDNQFVPAIDGGELETINPATGKSLGSVSAASVKDVDRAVAAARKAFNTTWGRNSSPGQRAAVLFKLAELMEQHAEELSELESLDNGKPRWIAETMDIADTAGCFRYYAGLADKIEGKTIEQKEGEKLAFTRLEPLGVCGQIIPWNYPIGMLGWKVAPALAAGNCVVLKPAEQTPLSALRIAQLAVEAGLPAGVLNVVNGLGPIVGDAITGHMDVDKVAFTGSTAIGKRVMERAARSNLKKVTLELGGKSPVVVFEDADIDQAVNWAALGILFNQGQDCTAGSRLFVQESIYDTFVPKLVEAFRQHAIGDPFDNKTFQGPQITERHQQRILDYIESGKQEGAKVEIGGGKWTEGAGEFANGFYVQPTIFSGCKKGMKIVDEEIFGPVMAVAKFKTEEEAIRLANDTSYGLGAGVFSQNASRCMRVSSAIQAGTVWCNCFTVLSNAVPFGGYKASGIGRELGVDAIKEYTQVKSIHWNYGESLDWPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWP1</accession>
    <name>W3VWP1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWP1"/>
    <dbReference type="HOGENOM" id="CLU_465383_0_0_1"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATA-type" evidence="2">
        <location>
            <begin position="436"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="588" mass="62774" checksum="1D630DDE97D23513" modified="2014-03-19" version="1">MAASTPLINSPHFDLGRHSDLPFMSRPKRSGSIPYDGGAATRAHYDHHPPGRFRASVAPETGDDSTFIPTSLGEHLLEQTYLDDVVRPLVRALVKARMTYTINSEGAAESSQAYADLDKLRRELERSAQRARHAEQERDDLARRLDLAGVPNAPLRDRTDCFPDHAAPAEPSHGSRIPPQPAPSMIGIKRPRPSEAEPPLRNAYEPRSSAPGSTGVSVNVPHGEGSASITVTTEGPSGPPISLVSRPHHVPLAEQMSPPSSYAHPGAARLRAYPDAHHNGHDAEPRHLTRMPLTNAAVEAEYAYADERERADRYAMAPVSSAHRPSMSARYAGMGARSPPPPSSSYLTSSSERSSMPALTTYPSTSSASSYSATPYSSTHPYDHEMDEMERSRKLARLRGEPHDHASMPPGRAMGTPGGYFTPSDASSYPVRKLASTKNRTCSNCAAPHDAKFRRGPNGPGTLCDRCGSRWKKFKEQESAGKREHDAVHHASSAAAAASAGAAAHARLSSASSSSQSPMEPSSGPSGAVDGAARASDGERAQSADGANGSIRRDASAAEISPTDATAASPLRERERERSASVDQLVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWV5</accession>
    <name>W3VWV5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWV5"/>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_1"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="156" mass="17281" checksum="3202A4003C289F6F" modified="2014-03-19" version="1">MPQVNPEVFHAKVYDITRLIPYGRVTSYGHIARLTGHPAHSRLVGSALKFLQDPDVPWHRVISSSGAIADRGDGGEAAARQAHRLTQEGVTIIHGRGEGITVDFAHPNPNAKYRINMTLFGWFPDQVHLQGYDEPNDEQIQDSDSDSDLTEPSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VCU1</accession>
    <name>W3VCU1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_06376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VCU1"/>
    <dbReference type="HOGENOM" id="CLU_024877_1_2_1"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="59"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS59458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="489" mass="55006" checksum="34AFD3011176CE59" modified="2014-03-19" version="1">MPDKRALDARDGPAAPTKRLAQYNDTDSAPDAILGSLKHPRMTGIPAGTSPYTASPPFQQPTPLCSFSFDEQRRLWQDDRCKRFYRGPPAYTNRHPVQTRAPAVFGADLNCAMDRYVQRDESVPEHLDALVAALQHRTETASAEVRDEVDQERRRAGVVTWRGIITKICTAYEQSASARFADPLDLNAMMVDGTLYLEEHVSASARAEKQRKEADPTMKRFAYYGYAFESYCTVDDPAQVSRPRSNDGEPEGWSGDVNTNVQWCSVVKTKLGSNRLIIGGEVDAVLPSHGREEMVELKTSMQITSAHRNAAKAAVEQERFEKKLLKFFLQSYLLGIGKIVVGFRDFHGLLTTHQEFETLRIPRMVRAGQPVPGQFNAGGQPVMRERSVWEAKDTLGFGDQILSFIRDVVSKHTASSPPADDVKGKIEHAVFRVTFHAPFEHVEIRALSQSEVHDEVQDKRQSGDRVGFLPRRFYEFVLARARARHSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VES9</accession>
    <name>W3VES9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VES9"/>
    <dbReference type="HOGENOM" id="CLU_018354_1_0_1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834081" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="500" mass="53726" checksum="D2365B70C4AB5D7E" modified="2014-03-19" version="1">MRAASLFTLMAATVSTLVTAAPPAPGAAVCADLAKALPATAGNDAVLTSSDGQPYTAAQTGGFNPLNNKLAPACIVQPTSQAQVATVMKSIYRHQANYAVRSGGHTGMAGWDSVQNGVLIDMSKLTDFSFNVKPGTIFVEPGLRWGDIYKRAAEYGVAPMGGRVQHVGTGLVLGGGLSLLSPQYGYACDGLVSAEIVMVDGSTRRVTADTDPQLFRAIKGGGGRFGIVTRYELKAYPTGTNEDKNWYGGSITALTPEGMDLMVQYTEKFVAATDDPKATLLTNVGMLKQNGAPLYLGSGFLFYKGTQDEFNAAFKDFLSIPGIIVQAQPMSYLEATAVTPLGWAPTQAYKWMGGSLYPNSAPTGWQATWDNVKAFLHRNEAVLESAFFSLTPVKTNQIEQGYQNGGNAIAPPRGKSYVHWLFSNILAPGTTAFPQTLESDRMAFLKQNPSSPGLPLFLNEVDASQKTFQSYGWFPQLLQQYYKADPTAFSMRKQQGPTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF68</accession>
    <name>W3VF68_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline-rich protein PRCC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF68"/>
    <dbReference type="HOGENOM" id="CLU_567627_0_0_1"/>
    <dbReference type="OrthoDB" id="2555634at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="48413" checksum="6D699079B1416D39" modified="2014-03-19" version="1">MSTGLASLAGYGSDSDEEETTPVLPPAPAASSSRLTSLLPPPKSTSLAAKLPAPSSAAGNPKYSGSSLSLPPPSASSSTAKRKVIKVGSLASLDDGDDDGEPDIVASGAKKPRLGMAASGSASSKHSLFGMLPAPKRMDDEVLAERKKEAQQRKADRLAEESEAAPIVAVPIQTQDDSVRSPSPGAMMPQVVEESTQDSDSKPKGKSNDAFRAMLGLKPAAKPPSTQPSQEPARSKPVTGNQLPPPRPKQPGTVPDPGASVAKVEAAPLDFFSLEAKPPAKSSATQFGNSFMISAAPSIDQPSEPDEPAAQTPLDEYPGWQLDTDGSWVPVTPEAHAQLAAYEQSLAPPPTATSKGAANLDGTRDLLAAGLTPDDIRAFDASAAARDAYSRGGDDDADADKYAAAAEFAAGNRDAMAQRKPGMLKGLKKGQLSSLISLADENRSKAEEKWKRGRDARARRANQYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFA0</accession>
    <name>W3VFA0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFA0"/>
    <dbReference type="HOGENOM" id="CLU_060158_0_0_1"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="58"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="387" mass="41366" checksum="473FBA1CC2DBB7F1" modified="2014-03-19" version="1">MAAIKAEHSRGRSPGPAADRRASVDNDVEDHDSPAPASNDGAPVRTSKRRKRSELSPSSKATHSIIEKERREAMNEKFSELAANIPELVEAMAAGKRPTKGEIVKASISRHQEQERRVRELMHEVQMLRSRSATPSNYAVDSPAPLTAPAAEPVAQAAQTLAMPYQIQSSHPIGVPASQDNLWIGQLLHKTGEPLAMSAEHPPLSLLPDLAQPISPFKQTSMMNWSMSALPQPLDASTLTVGFATSSFAKGLTDGSGTLEYLGRRNSLMGGMTSTSGFSSPTFTSSDSDSSFGTDALDTSLDDRKFFADGMSFEPFAMPSAVVEQTPLSSLVGLPSTEHASTAPTGGADKKPRARTNSRRARLDESTRTESSIWNSPLPSACLPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFD3</accession>
    <name>W3VFD3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_06374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFD3"/>
    <dbReference type="HOGENOM" id="CLU_001265_11_5_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="59"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS59456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="583" mass="64757" checksum="144F0341AB533377" modified="2014-03-19" version="1">MLVDNNDVARIDADTRDKLVDKFGERFDEVVERSARCTKWQTTTTLREAFRQWPMSVTWSVLFSLAIVQIGYDSSILASFFAQPTFTARFGTCTTAADGSQDCEISAPWQQGLTNGAWIGGIIGLQLAGSVAERIGHLRLMMVSVVLMLAFVFIPFFATSLPVFLVGQIFMGIPWGGFQSLASAYASEVCPVSLRPLLTTYVNLCWVFGQLLASGVLRATVQRTDVWAWRIPYAVQFFWPFPVFITCLFAPESPWWLTRHGKHDKAYDSLNRLLSGQGLAEKEKDELVKDYQAMIQYTEAMEEISEKENTAQKKNRYIDCFKGVDLRRTEIACWAWLIQITSGGPLQGYSTYFFSQAGLSTVNAFNMSMAMYALGAVGTILSWFLVNRVGRRQMYLWGQTAMFSTMLITGVLGFVKQSAAVSWAVGAMLLLCTFFYDLTVGPICFAIIAEVSSTRLRSKTIVLACNAYNIGLIIANILQPNMLNSDEWNWGAKTGLFWAGTGAVSIIWTYFRLPELANRTYGELDVLFGAKVPARKFATTSIDQFQAIEHEVASADVEKSSVSDKGGVEAGDGITVAQLPKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFL4</accession>
    <name>W3VFL4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFL4"/>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="35685" checksum="AFE495F6FE8C7389" modified="2014-03-19" version="1">MTQTTNGYQAAPLNGGVWTPLATPFLADEEIDYAAWKTHVLRLAGSGSGLVIMGTNGEAIHLSTPERFELVRSAREYLAEAGLSSTQIIAGTGTGSVKETVANCRDAARAGADAAIVILPGYFAGAMAKDRFAVKQFFTTVADQSPIPVMVYNFPACVGGVDLDSDQLIEIAQHPNICGTKLTCASIGKASRVAAAITRPGFHVWSGFADIIIPGMMAGMNGVIAGSGNIIPRTLVHLYNLTKQAIDEKDWTKLQQAQEVQKIVSHADWVLFKAGIPGTKAALERWYYPAGVCRMPLQPASKEVRAMLEAELQQALEFERQLEIKANVTPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFV8</accession>
    <name>W3VFV8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFV8"/>
    <dbReference type="HOGENOM" id="CLU_407164_0_0_1"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="675" mass="73540" checksum="4AB8337FDADCC446" modified="2014-03-19" version="1">MEKRERLLKSSEELDGADIGKQLKELDGLRQVWEAFSTKRKQLLSTLAMSQSDPDEDMRALATEELPLLEEELAEARSQMEELILSSITDAIEAQAVGAVLEVRPGVGGQESTLFTAEVARMYERFCEQKPADEDGSGEWQVEMLSSTSVDVSTSSSGSGAGLKEAIIEVKGKGAFQKLKFEAGVHRVQRIPATQSLGKLQTSTIAVMVLPISEGSENKADDLVDPKDVKVEVMRSRGAGGQHVNKTESAIRLTHEPTGITVSMQDSRSQHQNRTKAWAVLRARLLDRRLKQEVEGNRERRLAQVASMDRSDRVRTYNFPQDRVTDHRVNLSLNGIDSIMEGEHEPGTGLDYIMESLHIESDTRKIKALLESEEAEAAQASAGKKALAFRKAEGRRHTLCLLGCGIVSRHGNESRMGLSRLVEVATVAHGSLTHHNDVPLSQRAAPLPTHTPSASDSALCTTTIIATRTVPSQASASTSPLRTIKAQVAQKGMSAASEQPSAPNFLVDGTSSTVRGLDRTSWECLRSHVEELRIVAISSRCGAASPKDAVRKPDCIFDLCTDRDTTQRSVSQIFLQPTSNTVVPAKSLEELLEIDIVAPADPSMAKQRRIWLPTQVRNILDDADHLVTNSNASFPSTPASAPLHLAKPPESQPLAEFQSASARILNLVRGQPTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG29</accession>
    <name>W3VG29_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_06249</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG29"/>
    <dbReference type="HOGENOM" id="CLU_154847_3_0_1"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS59727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="101" mass="11377" checksum="E9B2AAACF67DA626" modified="2014-03-19" version="1">MADTHTASVDEANAARLPLGYRDQCSALLIPLNKCRKETLYAPWKCEDERANTTSKLHLNPAPFLNNTSESILTMPFGLNSFIRRQRELSQLKKAKAEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG55</accession>
    <name>W3VG55_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG55"/>
    <dbReference type="HOGENOM" id="CLU_035754_2_0_1"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000020">
        <property type="entry name" value="Checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="284" mass="31508" checksum="AA94512020E21F82" modified="2014-03-19" version="1">MRFRTQVADVSIFTRVVQSIGKVANKCILKLTPDKIHMICLGDTDGTQIWSQMQVDSIFQDYRIESNFQNHINLEVSPDTLLKALRSANNAYSVILRLAKRGKDPLLSFTISAQSHTGAKLEVVQDVLIKVLKPAEMSRVVEPLCPEPDVHIILPKLLNLRTVAEHMRSLSDIVTLSANRQGELRLSVAEDEVSLDTTWSNLAHPTIEASQSSAAQAPDDPAEHKSVHLEMKSFLKFLSSYIVATTTIACICANHCAIFYVYIGDVDKSSGVMTFFLPGVVRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGT6</accession>
    <name>W3VGT6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGT6"/>
    <dbReference type="HOGENOM" id="CLU_088622_0_0_1"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="206" mass="22051" checksum="9CBFDF9F5E629A55" modified="2014-03-19" version="1">MPPTISHVAAYSPNEYIQTALTGNKVSRKATILGSQNIILGGKCIIQHGAIIRGDLRRIVASSTSSSTGSGQQTQSVAIFIGRYCLLAESSVIRPPYKTYKGVFSYYPMKVGDHVSVGANTVLEAASVGSHVEIGANCIVGRFVIIKDCARILDGSVVAPNTVVPSFSIFAGSPATQIGELPETFSESCEAKMKDFYQRFRPTSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGU3</accession>
    <name>W3VGU3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-hydrolase oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGU3"/>
    <dbReference type="HOGENOM" id="CLU_017204_0_0_1"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF27">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="331"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="649" mass="71226" checksum="539957ADE80FE268" modified="2014-03-19" version="1">MTEPQHHPHLPHIGNGHHDGEVHHHRKLSDRLEARGEADGSHSPPSSRSSSSDDGVPATGADDTAKQNSNATGSDKQSLGYDIKLTCRSSDPASDSQTLSPDELPEHWVPTMVSQLNRATSSAFGQLTSGASSPRRNSTADRGGKDEQERESSEHHVLPRLTFCNPWSKSFRKPGVKELLNGGLKWGLPDSYTEGSGRGSVRASGFKSQKKAQRQLQLAKQQDEELGEGWDDVGVVQPHWGWPLSALQNEVKDIRHTNTSGGDVTGPSDGGEADFRAKERAVNEWCDPTDPSRPAARVTWLGHASTLLQLPPLGGPSPGEGREDVSGRSLNILFDPIFSERCSPSQSAGPQRFTPAPCRVSDLPPIDIVVISHSHYDHLDYHTFRELRHVRGDRIHAIVPLGVKDKLTGAGGFGWHKDQVSELDWWDHATLTSTGTGSAKVMCTPAQHGSGRGAGDKDASLWASWVVEWNNDGGRFAAFFAGDTGLKFHHDSPEKRHKYPACPAFGEIARRCGPFDLLLLPISVGSSLSYFRSWDPFPRAMSPFPRVSGTLTSSIHMDPYDAVECHTIFKAEEKKASKVVSVAVHYGTFVRNEEQTRADVRELRQACSKQRLRFARVRDETALLHSQSKDDVFIVADQGKTIWLPIHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGU7</accession>
    <name>W3VGU7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mig1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGU7"/>
    <dbReference type="HOGENOM" id="CLU_111242_1_0_1"/>
    <dbReference type="OrthoDB" id="2551558at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833037" description="Mig1 protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22371" checksum="25CC9795E613BC2D" modified="2014-03-19" version="1">MNSRLRSSLLFTSVLALFIDSASALSVNKRSVGDEANFDTVEACQVTELPIRGAEYEAVCGDKSDPKHPCFTHWHGDLTSVHIAPFLEPIDNIKDGILIKDDNNYTDFAFQNASDAYVITYVGSGQVQFVYSNYDPKTGCYDVTLRRGGAGRQWRIWFSDDVGSDRDLDTENYEVTSGRFCTKWGHIHVGYSDYLQWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGY1</accession>
    <name>W3VGY1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGY1"/>
    <dbReference type="HOGENOM" id="CLU_013933_3_1_1"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="669" mass="73491" checksum="D06AF159D492B01F" modified="2014-03-19" version="1">MDVTKAVSAYIQRMITEVAGIKVLLLDQDTTPIISTSFTQSSLLSHEVYLTDRVDNLNRDRMRHLNCIALLRPSPQSITALVHELRQPRYKSYWLYFTNALSKQDIELLAEADEHEVVKEIQEFFADYLPVNADLFSLNIDTPPARIWADNPATWDQSALDQHVKGLSALLLSLKKKPAIRYERMSGLAKKLGEELSYQINQDQAGLFDFRRTENSPLLLILDRRNDPVTPLLTQWTYQAMVHEVLGIRNGRVSLADADGVRPELQEIVLSGDQDPFFSANLYDNFGDLGASIKKYVLEYQSRTASNATIDTVADMKRFVEEYPEFRKLGGNVSKHVALLGELSRRVEKDSLLEVSELEQSLASVESHASDLKAIQTMIDSSKCSADAKIRLAILYALRYQKLPGNQIQKLVQDLLKAGVPESRAALVFVMLNIAGAEQRQDDLFANENFFSRGRSALKGLKGVENVYTQHTPHLVQTVDNLMRGRLRDTSYPLVSSSQHSASINPAERPQDVILFIIGGATYEEARSIALLNAQHQRGAQQGAAQQNAVGGTVGTGTRFLLGGSSIHNSKSFLDMIQDAASRFDARFAKPPANLGSAGPALNLSIGPVQLAVGGGPNASRQDGSVAGAAASLLDPEYLGEAASGARDLATDIFSRVRKGVEGTISGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH36</accession>
    <name>W3VH36_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_04898</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_15_3_1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05519">
        <property type="entry name" value="Bromo_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000104">
        <property type="entry name" value="Probable SNF2-component of SWI/SNF global transcription activator complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002435">
        <property type="entry name" value="Probable SNF2-component of SWI/SNF global transcription activator complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="15">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="14">
        <location>
            <begin position="412"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="608"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="925"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="1335"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1226"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1429"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1451"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1474"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS60968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1494" mass="168879" checksum="4ED2E667AE4F5875" modified="2014-03-19" version="1">MSSTIANGATNGSAPNGQQPALSAQAQQMLTGMTKERLHGMIARMQQLKASGVNESTSQEYATLVSTLKMFQQYQAMRQQQAVAMQARAAGQPQARASSTAQQPSAPSPSAATPAASATTPAADASSTNGIVVKTENDIARSLSPANFTPEQLNALKTQIIAFKLISRNQPLPSHLQEAILAADRESEAQDAKKAEPLASATQVAAAAIASADKGTTDDASKPGDAAESIAEIPRPPSPKHDPSSSIYPYNAYVHPFSYISKPLLEDEEYTATKQQRLLIPSLMPAGLEPRLLLEERDRFVQARIRQRIRELESFPADMSQNPTMASLKGKENAHDLHSQLNGSLQGDNAKLKALIELKSLHLLEKQKLLREQVVQSLNLATTLGLDRVAFRRVKKQTLRDARMTEQLERKQRVEREKRARQKHIDYLSTICNHGRDLVSAHTKANDQARRFGRAMLKFHADTEKEEQKRVERIAKERLNALKADDEEAYLKLIDTAKDTRITHLLRQTDAYLDSLAQAVQAQQNDDVHAEAIAAERQNEDTSNQEIGVAVDETMFGATRQDDPSEDRGKVDYYSVAHRITERVTQQPSILSGGTLKEYQMKGLQWMISLYNNRLNGILADEMGLGKTIQTISLITFLMEYKKQNGPFLVIVPLSTLTNWVNEFNKWAPSVSTLVYKGTPNVRKQLTGRLRSMNFQVLLTTYEYIIKDKHLLGKIKWVHMIIDEGHRMKNTQSKLTITLTQFYTSRYRLLLTGTPLQNNLPELWALLNFVLPRIFNSVKSFDEWFNTPFTNTGNEGGMMLNEEEALLIIKRLHKVLRPFLLRRLKKDVASELPDKVEKVIKCKMSALQLKLYQQMKKHKMILSGEDNSTAGKKAKPQGIRGLQNAIMQLRKICNHPYVFEQVELAINPTKENGPDLYRSAGKFELLDRLLPKLFATKHRVLIFFQMTAIMDIMEDFLRYRGFKYLRLDGSTKPDDRSQLLKMFNAPGSEYFVFILSTRAGGLGLNLQSADTVIIYDSDWNPHQDLQAQDRAHRIGQKMEVRILRLVTEKSVEETILARAQDKLEIEGKVIQAGKFDNQATADERELLLRAMLEADNDDEDEDDGDFNDDELNQLLARGEHEVPIFQQIDKERQQKDEEFWKSLGYKGKLPERLMQESELPSVYQQDFDADNVLAENAEEEQPTTRKRNVVHYDDGLTEDQFLRALEDDDVDINDIVERKRERIEKRRAKAMMQSLDSTEGTPDPETGRRKKGGRGRGIGASETPEPSPGPSGRKRKRLGVASMDGSPDYEESPSAARIAQPKRRKTGGEDDVRDRIKYALNQCYRAVEACLEPETGRKRCLLFLDVPRKSDYPDYHVIIEKPIAMRQIKRRIDNRTFRRVDTCRDEFHLMVRNAKTYNQEGSWVYNDAVELQKAFDATYDMLCRFSGLPGSENEGEVPSGGGETRDTSVAGDDDEEGDEDEEDEKPHVAAPRGIKIKLGKRSKPKKGRESDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH48</accession>
    <name>W3VH48_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH48"/>
    <dbReference type="HOGENOM" id="CLU_067862_2_0_1"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="263" mass="28418" checksum="C3D1F1C9363637E0" modified="2014-03-19" version="1">MASYVANKVTKRFVSGQAKRYEPEDPLYEFYTGNDGKQKRRKRALPPGLTRKQAKLLKKIKKRAHYLDKGFYVCGLRFGWTFFIGLVPGLGDITDAILNYTLVVKPVRRELDEAPDWLVKQMLFNNAVSAGIGLVPLVGDVALAAWRANSRNAKLLEELLRVRGEENIANGLPDLTPRSPNDTHPGQSAAQSHVQQSGGATSSAVGNGSTAGNSTTNLVHNNKAGTNQAAFQAPAAAGQQPMQDTSAAPASGAATKKSWFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHC4</accession>
    <name>W3VHC4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHC4"/>
    <dbReference type="HOGENOM" id="CLU_034027_1_1_1"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000004">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="309" mass="35361" checksum="8A549319F74614CB" modified="2014-03-19" version="1">MTSNPRERDGASLPGMVYAYPKPIEEDEEEEDEDVKFGEFEDEYESESPSESGTESLTWISWFCSLPGHEYFAEVGEDFIEDDFNLTGLNALVPFYKEALEMILDVEPPEEDSLKIPDVSIVESSAELLYGLIHQRYILTRHGMQQMVDKYEAGHFGYCPRVFCHSHPVLPCGRSDLPGLDTVKLFCPNCIDNYSPPSSRFHGVDGAFFGTTFPHLLYQCYRDLFPSIIAPKNNTDASTLQYQEQEAEADENKTAHRTIQPDQLGKRIPYSRIYTPKIYGFKVSEYAKTGPRMKWIRMRPSSLEEIDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHE1</accession>
    <name>W3VHE1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHE1"/>
    <dbReference type="HOGENOM" id="CLU_332066_0_0_1"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028018">
        <property type="entry name" value="DUF4646"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF143">
        <property type="entry name" value="FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASE PB1A11.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15496">
        <property type="entry name" value="DUF4646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="4">
        <location>
            <begin position="459"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="862" mass="94254" checksum="7A1DE95146EDC5B8" modified="2014-03-19" version="1">MSTAHGTSTHWAKTDPSVPPPSYNAAMGGLPSLRSSSPLDASSQHRSDDFSEKKQRERELELDPRRACPTTIKQVDPTYRSYSPSATMSLDPKTALARFGSPFATSPEWSPLPQDACLTRLPSLDLDLRIKMRFSSPSNEQRISAPPPSFHRRAIPSISSDAMQFEPVYIKSANNKETKKQILSDGFQPVYPGRLLVPRDVSAADWARFLDDIVAAGALTGKQKIVSNVAPITMHIGITGFLVTRAIQKGMKKRKSPLICETIENWQHQFFGARSLDVYVLYNGERLTARSPNGPIPASAYPAHPQLQRQDSHASSVSSLSSNSSSSSDSSDDGDRAALQTLDGRRLGRKERKLLRKQRKAERKQERKLAKSERKHRRNEKRHGCSPCSPLASQSPSGSRPRQDGARGGYLLVIAPLSASTASVAEDAAFFMCRRIGYREERQLPSGYLREIYVGGLSGVKPQTTDLKQLEQHAKAKIKPEAYAYVAGSASTEATAQNNLDAFKKWHIVPSMLRDVSLAEFDSSTRLFGRKYATPLVIAPIGVQAQLHPEDADCATACAAAELEIPFTLSSATSRPLEQVYEQAGFRTDPEEEDDGGVDAWFQLYWPQDDELTESLLARAKKAGYRVLVVTLDTWSLGWRPRDLDTTYNPFLTGEGVANVFSDPVFVRKYCDGKDPRRADVTPDEITSASVAAISQLSPGISRSWADLAQLRRLWGSAPIVLKGIQTLADAARAVEAGMDGVWVSNHGGRQVDGAVGSLTQLPAIADYIRSLPLKEGEEKKTVIFDSGIRSGADIMKALSLGADGVAIGRPWCWGLAANGQDGVRDVLKTLLADLELNAGLAGFQSTAQLSKHNLVRADSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHI4</accession>
    <name>W3VHI4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHI4"/>
    <dbReference type="HOGENOM" id="CLU_1189774_0_0_1"/>
    <dbReference type="OrthoDB" id="10386539at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="216" mass="23072" checksum="E877A20558BF2B52" modified="2014-03-19" version="1">MTVLSNLKISVNINLRDRDAPSLVLIKAFYDVTKDEYQRFAGEAAHLEFFERVDQGRCPYGNTQVKFRAPQKSAASVVSQAVSLGTRFGARIRAKALGRTSTRVDRVDRGKAAHGHKRSLSQRYGNGNPWRMAFENRPRISSNSAASTPAPAQADSTVERSETSIPASAPAPVNETNKDSMMKILAPEIHEAVAAALANALAAASAAAAGSCSGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHZ5</accession>
    <name>W3VHZ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHZ5"/>
    <dbReference type="HOGENOM" id="CLU_009116_6_4_1"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04934">
        <property type="entry name" value="ACT_AK-Hom3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04919">
        <property type="entry name" value="ACT_AK-Hom3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="555"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS61263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="633" mass="67329" checksum="5FA4FACEACB0CFD7" modified="2014-03-19" version="1">MPPTTHLRGPPDDPSTEWIIQKYGGTSVGKFLDTIAQQIVPSYLAGNKVAIVCSARSGQTKALGTTNLLLQAAGEALDEAHTPSASLTNSVASLASNANGAQTPVHRPGSAFSRKSSSRGTPLGRVEALSSNVLDSKLEQLKLNGKAAHPTNDAGSDSDGEIASGFNATVDRILSDHIASARKAVTKNKQLLEQIEADIVDDCERLRDFLLAAKIIEEISPKSKDIIIGVGERLSCRIAVGALRDAGVEAELVTLESIVDPSFSAHAVQDVGGEFTLDQAFYDQLSDALGDRLRACTGVPVVTGYFGNVPGSLLSQIGRGYTDLCAALCAVGVKAKELQIWKEVDGVFTADPRKVPTARLIPAITPEEAAELTYYGSEVIHPFTMEQAIKKAIPIRIKNVENPSGMGTVIFPDVPEGHDGAEDKLVDGHVDQPRPPMTPSASKSNFSAWGTSAKTDAARPVMGERKLPTAVTIKDNVLVLNVHSNRKTVSHGFFAKIFGTLDKYGVVVDLISTSEVHVSMAMAAGLRPRTLDKVKADLQKVGTVSVLRDMAILSLVGKHMRNMVGVAGRMFTVLAEGNVNIEMISQGASEINISCVLHEKLAVKALNLIHYSVLEVSPKPSNSEAGTFGRSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIC2</accession>
    <name>W3VIC2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIC2"/>
    <dbReference type="HOGENOM" id="CLU_279142_0_0_1"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000121">
        <property type="entry name" value="GTPase activating protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="581"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="935"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1038" mass="111268" checksum="29D2901121528BE7" modified="2014-03-19" version="1">MSSPSALTVVYPPSFQNSFWSYPSYRPGAQSLYAKLQAGLDENESILAFVAHRAELEYNHAEALATPPPAPSFPAPLFRQAAGILHEVLPIDSAGGSAATRGFAANSSATSRAFRMIQAETNTAHANAHGKVARHLEKSILEPFGRWAADHRTRVTQSWEHVDATLARFERQKSEVDKLKHSYENKCRAADEAEDDARFAPIDEADLPSPPPSHASDSTLRPPAAAAHPQRRSVSGDSTKSIDSHPDETDDPDRLKRRETLRKQFGFSQRATSATHSPPAHAALDGVKLPPLPTETEGEAMDASAASLAPPAPHATSLKRSGTISALVSSAVEKMPAPLKAAVGGVVSAEPRHARLRRDADNAEKVYEEAVRNLDRTRCQLEEVLFEHYGLTQRWEADRIRAVHSVLASYNHAVAAEIPILQQSSARSFQSSQGLDPSLELRALIRQARTGPFRPAIERFQPYYHDETSLGRKVGPHGVAHAWLVKNGGFGLDLSLVERLEYLERLEHQPSAPESDNPTQLATVPPVLAALLAALDRAYADDERWTALAKAFAAANAPAAPADQSSEDQTAKDEAADEPDAKLIGQEKRKIWILEVPLPITHRLRDALIAHLNPSLADLIYGGTNGTKAADAAESPANIIPEKLLDSYDAPVLAACIKLWLLELEHSLITEELWDQIDAIYRAAAGQELEALSAATPVVGSSEEGAAAAKDGEPAATPKASAIKRPEVDGATKAKIRAGVLEDLRVVLNKLPRIHLACLDALFSHLHRLVASTQAAEADAVYANKLGLALGRALVRPRHESAYTLSSQIGTLVVYDLLHHYDDILPELVEKKRTEAAAAAAASPNAKGAPADGQRRMPIRKRTKPIDQRISRSSIGSDLQQGARKLMQQMDERERSKVEPTPIVTSSDAATAEAKRDDDIAAPTPLAERVLGASAAANEPAKEAETVSVVDDSAEQHKEQQSQEAAQAQSAAAAAGAADERPLSNVARLSRQFNSASSTGSAGSKRSSLGGGGPRGPRAPSSRTPSAGVSDLGDADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VII5</accession>
    <name>W3VII5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VII5"/>
    <dbReference type="HOGENOM" id="CLU_1384695_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="197" mass="20694" checksum="410189C220D63B3E" modified="2014-03-19" version="1">MGAEQPRRAALFDAQGRAGRWTPLQLQIHGSSRAAFLSASSCDQLQLRPAAAAAVSARTASRRAEFAPKLTLPGPIPAAGDTPSGAAAAQRARERLISRASPDALFGTLARHSSSALPRSTAVLLFRHSSRSARSAPLDVSSPPPTFPPPHLNLTSTSFALLARQIYLSSHCHRTAIALPFSTGISTRASASLHTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIJ2</accession>
    <name>W3VIJ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000017">
        <property type="protein sequence ID" value="ETS61320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIJ2"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834551" description="NAD-dependent epimerase/dehydratase domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="351" mass="38431" checksum="F3750757F6D3BBF5" modified="2014-03-19" version="1">MSGPLVLITGITGFVAVHVLDAVLASPQNYRVRGTLRSLSKSDEVLERLSPRDRARVEFVHVADTATSDLRLAVRGVDLVLHVASPFQVQINDPETDLLIPALEGTLNLLRFAKEEGKIKKIVITSSFAAVSDPIAGDIKRPGYVYTDKDWNPTTYEEAKTATGPGASVLAYYASKKVAEKAAYDFVAREKPAFEVASINPPMIYGPTLQPRVTRKSLNLSSAIMYGLISGLDEMPSDDLPLFCDVRDVALAHVRAVEKDGAMGERYLLCGGKFSWAQAAELLAEKRPELRALLPKGWQQAPSIDLDGSFASMDTSRAREKLGIAFRGWQTTLLDSVDSLLELEKLPSWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIK2</accession>
    <name>W3VIK2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein scd2/ral3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIK2"/>
    <dbReference type="HOGENOM" id="CLU_014957_0_0_1"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000050">
        <property type="entry name" value="Related to Protein scd2/ral3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="168"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="369"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="78547" checksum="8EC046B0E36978D2" modified="2014-03-19" version="1">MKGLKDFRRSLNKDRHSGGKPPTSSASPAAFTNVKSAVTIQPPKLVIRAVRDYRSNSPHELSFHKGDFFHVITDPAPNADWFEANNPMTNARGLVPASHFDVLSKSNRANPATFAGPGATSPQIGSMSPPTSSAASTTGVPPPPSGASLSSKAYGGRAAGAAMTAKGGGGLYAVVKYDFNAERADELEAKAGESIIVIAQSNFEWFVAKPIGRLGGPGLIPVAFVEIRDLVSGRPIDDVQELIESGVVPKVEEWKKMTAEYKKNTIPLGRFDFPQSSQQGLNSPYANMAAAASGSSTNNAALPRSDMHAHQASISSLPVPTPPPKDDLYNHTGGPLGAAGAVQPFDEHDPNAIDPLTQLPPGMSPGEPLPTGIITSATVDSFHYEQGDYWFRIQATHVAGPSPSAPSNAPTAPDGEERDLILYRLYEDFYEFQIALLDHFPAEAGRETDANGHSSERILPLMPGPLDVVDDLITSQRRVDLDQYIIELCSLPEYIMRSELVRLFFEPRPGDHCTAHPARGPTDEQDNNLQYNDYGYLAGGVDAGQQRNQQTTQQQQQLRSNGVNKYAEDQPVGRASTSSRTEDELSAKMRGASLGGGSGGASSGQRDSARSSAAFGGGVGGTISTGRTSQASSGHRKQNSSGPSTQPQTSGSAASVPYHRIKVARRNDLDSVIALRMPPSPTYAQLLEKVRERLGADVSVFKCNEKPDLIDDDASLTAWLDEATDRGWKLMLHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIK8</accession>
    <name>W3VIK8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIK8"/>
    <dbReference type="HOGENOM" id="CLU_059979_0_0_1"/>
    <dbReference type="OrthoDB" id="2554527at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046310">
        <property type="entry name" value="DUF6425"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19989">
        <property type="entry name" value="DUF6425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="388" mass="41186" checksum="4ADACC536F970145" modified="2014-03-19" version="1">MTYAQLSVECPAGRPRCGGECHSILAAGRPSGGCSRSSCQAAGVGTRDPRHDIVDRKRTASAGDYQSVRFTVAHRRFWASTLAHLVLEPALALPSPSLASTIPAFTMTLNTLLMQRASMLPTVSRRAFAAAARVHNAQPQLIREGPAAPKNNKERFDDGRDDAHYPGVQQKIKAFNETYPNRPNASRPSPEPESPGGHEGAFADHRGRGERTEHEQLKGSEEAAETRTHKRVGQIARNAAQSLFGSKSFSTYAALSAQPPAAPSRTSSAASEKGSVSDHPGYTTADAPIDSRPPSEMPKPAEGAMPSSSVSNASTKAASPHPEVHTMAKGAQTSGAGQDAIHPEDRSQSTWGANARSAQFNPDEGKRQPLHHGGSHEGGFEDNGKSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIS4</accession>
    <name>W3VIS4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIS4"/>
    <dbReference type="HOGENOM" id="CLU_128881_0_0_1"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="179" mass="19821" checksum="44659CBC79ABD38D" modified="2014-03-19" version="1">MFASASRSSAIKSLYQNVLKEAERSAKTGPLVSYLQREYKDLESGAAGEDKVKATSDYIPFVAPAKSAPELRQQNLENLHVFLQNKALHAELLQRYNPTSGLTEEERVRLTARRVGLDVPITHNPSAESSEASSNYRESAKIAQDQYKQDKDSREDQLYSGKGDGLNVGGPLRPPVNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIU0</accession>
    <name>W3VIU0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIU0"/>
    <dbReference type="HOGENOM" id="CLU_066933_0_0_1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036524">
        <property type="term" value="F:protein deglycase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017283">
        <property type="entry name" value="HchA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003168">
        <property type="entry name" value="PRK04155.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF20">
        <property type="entry name" value="PROTEIN_NUCLEIC ACID DEGLYCASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037798">
        <property type="entry name" value="Chaperone_HchA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="294" mass="32400" checksum="91827D8F438A5F8C" modified="2014-03-19" version="1">MSQTNDRQPVADQAEFNAFFPSPFSLTQYVPSKTDFDGAKYDAYTGKKWKVLLIGSQERYLKMADGKFFSTGNHPVEMLLPLLHLDLAGFDVDIATPSGDPVKFEVWAFPTEDDAVKGIYEKYAEKLRSPLSLEKVWGSGFDKATPYLGVFIPGGHGVLNDIPFSKTVGDVLRWADANQRFLITLCHGPACLLAADVEKPQGAKYIYDGYKIVCFPDSLDKGANIDIGYIPGKMPWLVGEHVRKLGVEIINDAITGQVHRDRYLLTGDSPLASNNLGKLAAEALLEEVAQRPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIU8</accession>
    <name>W3VIU8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIU8"/>
    <dbReference type="HOGENOM" id="CLU_894275_0_0_1"/>
    <dbReference type="OrthoDB" id="9445768at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11802">
        <property type="entry name" value="CENP-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="311" mass="35107" checksum="9F9E0E0C17088F25" modified="2014-03-19" version="1">MTGSNFHDLAEILREAALQEAANRTKQRSQLIASAAAASSDRLELDAQTEAKADELLAVYEDEKAKNDALAKSLDERLEELARTGAGKTDEKTDGDQRRLELEWQQLDFAISALEKENKQAPALESATVLDVRTRSELHDLNTQYASALDMLKAELGAEREALAREKQLRADLDVVQLGLTKRLAQLQRKRTQDLTSESAIRDLSRKFRREEHVFKELLAQLIDMGSALFGADNRKVVTLRHYLDEFMNQAWDHPLDPWVSASKLALRRTGGEVDDAIIELFLRANIVVAHPKDARRWRLVAFHKPTRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJH7</accession>
    <name>W3VJH7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJH7"/>
    <dbReference type="HOGENOM" id="CLU_101497_0_0_1"/>
    <dbReference type="OrthoDB" id="3358293at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="237" mass="24586" checksum="3BDECBB241ABE47C" modified="2014-03-19" version="1">MVFQGFGIEASSYNPINLSHGSVAAPLPMAGAGGCSKKRKAFDDLDSYADATGDFHVRPKLSLPRSAGLVFNGDAQFHPLPADVNQAMLAQLGHNPFTGSSTSGSTFVTPSSSSSSGFLAGHEHKSSNGSDYFSTAAPSQYPDVEPYPPTSPTSAYGILGPAPGRHNSFSDSNSMDVDYGSSASSRSVHGPQCKSIPQLCVRYNDGSGSELWATCPDCGACSKVESNAPSSNLCYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJI6</accession>
    <name>W3VJI6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJI6"/>
    <dbReference type="HOGENOM" id="CLU_000288_57_2_1"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="377" mass="40360" checksum="7362AFC61202D462" modified="2014-03-19" version="1">MAEKRKTSPPISYREAALVKRQRHDADDGAAGSQQIAIASSKDGQDKGLVRSVKRTSSLSHPILGLTGAHTSEILDAKFSRDGSRIAAASADRTISIWSVYGDCANIGVLKGHSKAVTCLAFSNTLSDALYSGSADGTLIAWSLATGEKQRRLRGHRAIVNRVSATRSGPELLVSGSDDGKVMIWDPQAKEPLDVLDVGYPVTAVAFSDDSSQIYIGGIDNQVHIYDLARKTTVLSLRGHMDTITSVSLSPSGSHLLTTSFDDTLRIWDVRPFAPEPNPADPNANTANPRLYRTLRGTTFGGFENLLIKAGWSADGEKVVAGGADRTCTIWDVESSTILYKLPGHRGTCTAAVFHPREPVVVSCSTDMTLLLGEIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJN8</accession>
    <name>W3VJN8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001910_0_0_1"/>
    <dbReference type="OrthoDB" id="3360262at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1666"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1719"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="841"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1670"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1727"/>
            <end position="1739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2091" mass="221483" checksum="8F05C84B4A2E9DA1" modified="2014-03-19" version="1">MSAASTSAAGAEAHAVARKPSKLLARSNTLHRSPHGHSGSGAGLWLANSPSPDSSTFAIDKDASPLAPLSLPSNTTHDEATDTAQATHKHAKKVYHFSAQLARASFGAPLALGASSLDSTYVVAPASSAGRVSSDSGDVDLDLSFDYISRFDRESSSEAPDSSGSALETSHDRNLPLRSHFSPDDTPESILAPAHHDASHISTPPRPSQENSNVATADKSLSASPDARTSPSPNSKLMRSMRQDADWDKRRKAPPAPLDLTPGSEAKRQRQLAMTASDARAAAHARPAAELRPSSGELVGQSIFSPITPATAIVPPIAALGSHPQLEPLPITPLSATRRGAAINRLPDNAFEVEKNQLEATPDSAAVRRAASTSAARIGTRQSSEALSRTPTASHSTASSAKATPVQARRARSHSTRSFRASASLASLGPPPFPPPNEPLPSPALSPSFHDYSLPSTSAYHTAIDAGESRSNARTARPSVSSVDFSEPARSIRSRTTHAGRSSLDSFRTALSDGMTGAASSGSIHGHHAAWTTEGLPMPPPLPPLERYEALFPSGNGWTAPAPPTVPAGLDGATPVSSNDMLGIGATSSINTASTLTSVPMTLSSTVGSATTMTWSMSDRSTPSTHHSPLTPFTPVFAEMIVPPGATTKTQMATATHAEMPSLGTAATDMDTGVGGRGARNTEQWILTQRQRKALLQQQELAADQQMLDAGHEAMRLSIRADERPSRGLNSRAESAATKPAQDGFGEDRTRQDSRSTESTDDDHPSRLRQTLVISTVSTPDERDEPFRFGSTQTAPSLLAADNRAAMERAASHSGVLASTAAGPVPMTRNRSGTNGPWPQSPLLLDPKSPAASPAPTTIVHSNYATPQLESDGHKIATHASGDESTVQGLGLDLEYPAQVGGSAMEAPKGFAPITTDLLRQASRCMTRFPHDSASPHLSITMSPDAEALGRSRSKSREAVLTRTSRHDLHHAQLGLGLNFAGPSPVLPNDCRSPRTASGLDKGSAAPAGLDSLLTGPVPASAAEVIVNRAHVGTDRALLHSQSIASSISAFAYNPTPAGPNTADANRSLQPPRGKGSNGWRLNPRRSRDHGSMLAAPMRGGSDADVKFVNIDLDDGGLETEVALDRGDARRAAEQGKAGQWVSKLWTAVSSPRRTSFNLGAAVGDQSVDLELANTSEEAEHKEAPAPLEERKASRGSFRPLSLVEKRQSSGRYNVDLQRQRFRSPTPGEEDEVAEKDARAVALRLLAGSPRLPAPAEAEAMEACDPPTQDGADVSAEEREKERMDALKKLRRMSAVERQRKRNSGIGYIVSAQEPTRLPYVHDGAEGEAHRKRESILRQGGLSRTASLTSKRMSMTTFGGKERADTVPATAADEPPQVGAERAWLDALRSPRVAESPSGYTPRMAFEPHDWAANERQEHTPANHIPLLLAGSAAPAQRAVPAPAPANGIGMTVSELDRARDEMRRLAGQGATWNDAHAQHAGETFHTPMPDTGEMADPWSYSGQDAAARNKHEHRRVATTELGDFGISPEKQPRLHRRTRTARFAVDDDDDEQPAVSIFTRAASQHRARASGSFSMHHGAGTQPPLTAAHAGYKRSRRGGEGGGLFATPASLLEGTTPSKNMFWAGFLGMPWLWMIGGWYLTPDGQLRHPSSDTRARDKVDVWQHEPSMHPHSASSSPNPGSSSTFVGGASYEHDWTHDAGASQSGLGFEMSGMPSGMSYAPSSVGTSNSARTTSSNANQPPPSKVRKSKTRSLGSLLDTNPQVSFFQSPVRAVPEAAPGSTWHGRAMEPVEEVEEPRRSRLFAAHAEQALPSELEFDGMQRSNEMAPPKVQGYQVAVATRSAVATPWRDLERYVLLNRVAAILSGVLWLRTQALNARLASSGKPLDSRIRGRYEKLVQIQLQQQQQQQQQQQMREGARAVAEATRASVPPRKQLIEAIRGGDGASGKATAPRGLTSYDAVRWLSSQSGPARKAGGDDTGATLAAVDAAKSPTTGSSGNGSLLMAGAAAALAATSSGSGLGGLMSAMLSPAAAAVAASEPETTPLLGTYNQLVFLRAIFRIVFRVIVLVRVARFHNSPTPLSSLVLGELLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJQ1</accession>
    <name>W3VJQ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber evidence="15">3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_03997</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="15"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJQ1"/>
    <dbReference type="MEROPS" id="S10.007"/>
    <dbReference type="HOGENOM" id="CLU_008523_11_0_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="595"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS61888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="645" mass="69880" checksum="B235E27D945311B9" modified="2014-03-19" version="1">MPLLDPREVLLRRGIPIPAASSFHVPGLPDLHGEGSSSSAVGHPLQMSAGYLPARTQGTDGQPKDNAHLFFLLLRARHVPAKRKLIVWFNGGPGCSSFDGAMMEVGAWRMDGKGGLVWVKDGASWNEYADILFLDQPVGTGFSYVNTNGYANSLPQAADEVFHFLHQFVQVFPEYSRDVELKFGSQGSGVDVYLAGESFAGQYIPYTAKAIVKAHNPPVTLKGIAIGNGFIDPKNQYGTELETMIDKKIWSTSSDDYKRVSNIVDRCHKELARLTTSSGSPREIGTCDEILQTIVAATTAKPPGSSAFTCINIYDVRLSDTSPACGMNWPNTLSAMYDYLRRPDVRKALHVDDNHKPEAWVECNANVGSAMRSDTTSPASVSLLPELLESGVRVLLFAGEEDLICNAIGVRRTAENLEWGGSKGFGDHPAQQWFVNGSLAGTWRTARNLTYVGISGASHMVGVDKPIESHDMMVRFMGIDYMKVAGPNAMIPSRVGDEPDRILVTGGGGGVAQIGKDGSPVIPGSGKTEAEVAEEARWRAYYDAGSLALVILLIAVSVGTWLLLRARKRRRMDTNRIGRGGALRLATTTEFGASQAATGGENGDNHELERLVSKRSPDEEDAIFDVGDDELSDSNSDEQPHKPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK34</accession>
    <name>W3VK34_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK34"/>
    <dbReference type="HOGENOM" id="CLU_064992_0_0_1"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="199"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="294" mass="31469" checksum="33CBF5EB151BF1F8" modified="2014-03-19" version="1">MVATPSKQAGASGSTSRPKKASAKAGLVGTPSKPAAADEDVVLKHSKPFGQEGDDDSDVDLGDETFATAPAMDEDDELMIGTSTAPPATPSASTEESKPSFKPLGSASLTAVAKGQLRKIPIPPHRLTPLKNEWHKIYTPLVEMASLQVRMNVGKKCVELKSSRYTTEQGMLQKGADFVKAFALGFDADDAIALLRMDDLFIDTFEIKDVKTLQGDNLSRAIGRIAGKDGRTRFAIENASRTRLVIADTKIHILGNFANIKIARDAVVALIRGSPPGKVYANLKTIGARQRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK37</accession>
    <name>W3VK37_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK37"/>
    <dbReference type="HOGENOM" id="CLU_735931_0_0_1"/>
    <dbReference type="OrthoDB" id="10338734at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="376" mass="41162" checksum="DF1E8091A26E418A" modified="2014-03-19" version="1">MPVQWTSADGRTITINANKHTTLPSSADIIEMCGSKTLDKEVGDELVALSNTMISDFTKPLETIAYQYKACKKISKHEERLRTCVTVLVLAHTILGHFSERPRLLAEGKELGDTLGPTTVPQALNNRQRASKVSAGLNTFLFHTKMSVEDVAALFGLPPVDTQPMQETQGDSQPTASEAASPSSSHAHQPLSPRIQTPPLPDLPWRVRALQKHQRGPQFSQQDDGPNGSASTGPPTQTPRKGVACSTDNARTSKRSRNSDEESGSPEPDERHPESFYEGRQPLLSDAQFRQAVTEVYRDFFDNYTAHIHTNLAGPDASEMALCVLKDGLCNSMWRLLNFRGSGFTSVFGVISEKHRGTPLPGRAGRSSRRSSNTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK84</accession>
    <name>W3VK84_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK84"/>
    <dbReference type="HOGENOM" id="CLU_036517_0_3_1"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="295" mass="33033" checksum="D88F38493CB4D8F2" modified="2014-03-19" version="1">MSSGAALDSILRRECSHIGKSFEHSGASRFIARPSGRSLFAKLDDHVEQTLGEAHSLIAMHKAQSGSSGEPAATLSPQVHAFGKTQDGNRAYLVTDYLDLKPSLGRDAQKALGRRLAEMHKHGRATGMLTRLILGTPSQRQDNTWEASWPTFWAERRIGDLVNRIHASHPDPQLRKLEEQMRDRVYPVLLAPLEGKIKPCILHGDLCSSYYGHNEADGPARLGIMHMFGGFTQDFFDAYHEVMPKTEPYYDQRVRLYELYHHLNHTLMFQGGYRSGAVAIMKSLIDFCDGKSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKD1</accession>
    <name>W3VKD1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKD1"/>
    <dbReference type="HOGENOM" id="CLU_371400_0_0_1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834270" description="GH16 domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="6">
        <location>
            <begin position="88"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="784" mass="82892" checksum="12146CD2E1FE8F7D" modified="2014-03-19" version="1">MSATMTRVRPKLISRLAWAMLGAWLMLSSLTPTSNNGSGLGVAAQSTRITCSATSQCPSSSPCCSAEGVCGSGAMQCAGGCNPLASFKPTSCLPNPVCRSRNMTIQPGDFDNLAIFTPILQYGGDASKAAFTLDSGSLGPGPEGVLLQLKAAQQAKISTTDYLMYGYVEATLRHDARQGVVAAFITMSDVKDEIDWEWTGANSSEAKTNYFYMGEPVLDHGTDVHMTGNNVSDWHTYGLNWTSSQLQWTIDGNVVRTLTRDQAGAEYPRSPARVQFSTWAGGNETNPEGTIDWAGGPIDWTTPEYKKQGFYSQEIKQFAVQCASLSGLNLTSASGGAGGTGGGNVTSFVYTGANSSSTSGPAFGTSTAPLRILSDPGVDGIPGYPGFKSASDSSTSDSKDGKGSASSSGKDSDNGDKGQDGDKSKDDDKDSKASAKDDSANSSSTSTSDALKYALPISGAIVGLAAAWGLVAFVRARHLKAPIINAIGVTGVNDPRFSGPSNRGYVQAATGMHAATFQDLEDDPQTVYRNEPNMNLMMGGGIMSDAGLSHLQRQTTGSSRLTRNSSRTITDRLLQNQSRKYQQLDATTEEEGMEDAARHTLSSVVTSRRHADSNANAAMGYATDGSRTAEDRHEYAVRESGWPGHGYRGDYDARMPDGGMDSWDPTPVSSPIKAGAMRTSYREPARGPDSSFEACQLQSPQRRALPIPVTPYTPNYAQAPQRPSGRMYDTPNVNYYPTPVIAPNEGCMAGAAPLFGGGHAYAPVDGAMGGAGYVPTPPPRRHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKI0</accession>
    <name>W3VKI0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKI0"/>
    <dbReference type="HOGENOM" id="CLU_010060_1_0_1"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="496"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="693" mass="74093" checksum="2619B268045CC5A7" modified="2014-03-19" version="1">MKRSLSPMYDTDLASLPVSPARGRSSTSTRSVASVNAAPSTSALSSAAVSPPAVTYNVAAKPSRRSKFALAAFIETNINSGTDGGLYAETIRNRAFQDNVNNAANTNNALGRGSLLHWTGTSKGTKLTLSLDNSLSAALPQSAIVTGQKTDSCGIANSGFEGFSVTKQPYKLAFYARSPTGKPTTVPVEVGLYSSDSSKTFAKQTLPLKLSGEWQKFETTLTPSQAASNNNNVFAIKTQGACNDGFQLNLVSLTPPTWQGTVARPDLAQALADIKPKYVRLPGGNDLEGNNIPSWFNWTNAVGDLKNRPGRTPTWTSDWNTEGLGLMELMNLTEKWGAQAVLGIYAGYSLDGKAVPQNQLGPYIQSALNQLHFLLDTTGRWADLRKSYGRAAPYKFQHVEIGNEDWLGAAVQTYGPYRWAAFRDAIAKEFPQLTLIASTLLNGVEGAKAVDNHFYATPSQLFAFAEGMDATSRAIPIWELEYAVINNGLTNDSDIYSGPGRLKHPTLIGALAEATFLAGAERNGDIFYSAAYAPLFQNEGTNLTQWTPDLLSFNAGQMVKSTSYYIQYAWGNYPIEQIHDTSLSTPTNSSHIYHSFGSDGQGHLVAKLINTNAGARDVKVQLGSGAKLSANGAKSWQMKGNDPQAANTLSNPQAVVPQSSSNELPPGAQLTGDGSLTVTLPAYSATVLNLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKI2</accession>
    <name>W3VKI2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKI2"/>
    <dbReference type="HOGENOM" id="CLU_1409356_0_0_1"/>
    <dbReference type="OrthoDB" id="3141857at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="193" mass="20701" checksum="1D494EDF47EEC68E" modified="2014-03-19" version="1">MSGPTQGYPKSQASVPPKVSPEPPAVVVARILPGRFCSRRATINGRFGAAWPIRPSASSSVIPSSHLLLYSLGTVGLFLYFHQSKARDTPVGKALHAPVKPNTHGVASSQPGARQAAYHAEPHSPRGLAPYVLPHLSEAEKAELEIVPVPRHVGTFGKTMKQAAVLDRKGHQESIDAARDKARNEMPVRDQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKT4</accession>
    <name>W3VKT4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative peroxiredoxin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03686</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer; disulfide-linked, upon oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKT4"/>
    <dbReference type="HOGENOM" id="CLU_072440_1_0_1"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Redoxin" evidence="13">
        <location>
            <begin position="94"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="11">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="259" mass="26965" checksum="9EBBB7AD9BEB933F" modified="2014-03-19" version="1">MVSKLVMAPVLRTAGSLARPAVQPIVLPASRRLISSASSPFSATTTTSNAATLRNAFARNALGPCAPALGSSCVKSSPTLVRGLATAAQTISKGEQIPNSTFMYVPFTSELADGTACGAPTKVQTHEAFKGKKVVIIAVPGAYTPTCHVNHIPPFIKQVDAFKAKGVDQIVVLAQNDPFVMSAWGVQNKAEDKVIFATDLGLEFSKGVGSTADLSAMGFGMRTGRYALIVDDLKVVDFSPEPNPGAVETSSAEAVLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL27</accession>
    <name>W3VL27_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL27"/>
    <dbReference type="HOGENOM" id="CLU_070358_0_0_1"/>
    <dbReference type="OrthoDB" id="3363403at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="260" mass="28175" checksum="9026044597642A6A" modified="2014-03-19" version="1">MAYLPPIHTLWEHTSHPSKGAWSRSPSPEPVHHEATAGTQAGPSTQLTPARQAAVQRRLIRQSTRGDHLPARTRSAEQARMLRALKGFPPIGSSADADQLSDLEESIEVGKYQMVRFGERYIVQIGRRRTMREEELSNEEDDGRRAAMSAVDTGLSIGAEGAVLTAEDGSVLADNESGSIPFVGGHTGHAAQAALEQRQIAEAERRAREAEAEANRAAAAAEAARSQAERQAAFQEEEDAVDLDGDIEDLDEGDEDVDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL35</accession>
    <name>W3VL35_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TFIID-31kDa-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL35"/>
    <dbReference type="HOGENOM" id="CLU_068315_5_1_1"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23866" checksum="EBF7B33DCAFB18B1" modified="2014-03-19" version="1">MAMYQDDAQDTGLRGPVPRDARLIALILASMGVSDVEPAVLLQLLEFAHRYTYDVLSDALVYADHASARQASSSLSLDDVNLAIQSRVNYSFTKPPEKDMLLALASTVNAIPLPPISDRHGVRLPPAAHCLTNVNFSLVPNPPPADAEEFEDTTLLHQSQQQTQTQAQSTQTSSLFDANTAHDDGDVSMTATQPSQLTAPSQSDDARGTKRSLDEDEDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL70</accession>
    <name>W3VL70_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL70"/>
    <dbReference type="HOGENOM" id="CLU_027938_10_0_1"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="129"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="369" mass="40650" checksum="5500D11781EB1826" modified="2014-03-19" version="1">MTPRAESSGILLAPCHLVFSLITTVVAATMAVLSKSLGTLTAGALMLVALASPRSQRMRFYLNSLIYIAGLGICSFWGIVVSIVMSLIPGQRLNINRVVARSFWRLVSPLVGVRFIVEGEEHFDQARPAVVVGNHQTAMDILYLGRIFPGHASIMAKKELQFAPLLGQFMTLSGAVFINRKNLKDSIKAFKQVGDTMNKNKLSLWIFPEGTRSGLATPDLLPFKKGAFHLAIQAGVPVVPVVCENYNRIFDSKSRFESGTIRIKVLPPIPTSHLTAQDAGELTETVREKMLAALRQMDQERQQNDLNPTDDYDTKPHGLVGFLARFLGSSHGFKKINAQVDRTEQKLRQKGDGSQADDYNLVSEAQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMC0</accession>
    <name>W3VMC0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMC0"/>
    <dbReference type="HOGENOM" id="CLU_046061_0_0_1"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="356" mass="38265" checksum="B6625CC443FF5BCA" modified="2014-03-19" version="1">MSGYELHQKLRTKVVRLTKKKAYPEAIAALHTGALELLSQGEQGSGCDLGIYMLDVYNLADTPVTAESRSRITDIIAAAKPDFWRKKLVDAAVKWSCKSGGDGELRLFVAKLYAKDGEYSLAESHFLAASGTDVEAAKEFARAMAAWLSAVAKRAAQEEGEERTQDAIERIEAGGFALRATLPLLANNVPAAVAFVQTYLETLTARLRSLLLPISPNPRAFSAPNGTQTDFKLSITANSELNFVQMATALSLAAQAGVNDALRTAWVNLVRQFERESQPDANAASAIAQIGTTVFGIAQRRQGGNMLTDMMASLFNAPPQQQRVAPPPSQSTQPAPPQASPATEAKADDLVDDEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VME0</accession>
    <name>W3VME0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02409</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VME0"/>
    <dbReference type="HOGENOM" id="CLU_023311_0_0_1"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="206"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="522"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="639"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="654"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS62675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="806" mass="87042" checksum="B08DE8C248030F07" modified="2014-03-19" version="1">MASPHVLYYCPCSPHNPNDASSSSAGGSRQTSSLASPPPGLPASSPASSHAFHPLESLYFCDECNHIRCNRCVTLDISSYYCPNCLFEVPGASVKAEKNRCARNCFVCPCCQHTLSVLASDAQNARDLDPTDPVASQGASPYYLGCSFCRWDSRPIGLVFDKPTGLSLQLQRSEENAPDVLEFDRLKDHFDPYLKTQTQAAIASAAVGSSSGSRSRSSQSTAATATATESTSSSDPARSSRTSRVTAARNAATAALSSSRLLRDLPQLANSRNPHALSSAARSAPIEPDELKTYRALNPWQAPADSRRSSSASSSSMGVVAKREKHRRDYLARIQSAPNQPITSLDDKIASLQQRWSSASIADQPIRAADLRPTRVPLKSKLSKRCPACRHIVIKPDIKAASNRFKIKLVALNFLPEIQLALAPQQPHLDPLRFRSSATSGQPFTPAGSLRRRPLSVLGAATASAPSDPLAPAASSITATSHDVDVNNLIPGHTYSFQINITNPLDDPIEAHFNFVRFAPPDRANKSSSTNAHRQSTVQTLPEPRYIFSSPHHPSKDQSTPQAEPKQTSAKPSRRPRLGWQVYPSAYSVPLNAFNEVWELEESDDLIASKSGTDTAQNANSAQINDATHRHYAVKTAIIRGSGTDPNDSSAWAIEDDEQDDDDDDGYDDTDDDDADTDNADSALSNIQEEQDSTASPPHNSAQTARRQRASLLPSARRRRRPRQASSAATNQRPPFIQKGHTTTLFLDLAISSNDAPAPGPIELGMHVTYRYTAAAAEPAEPPPTGKDSSFWTSLRLGTIVGASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMK7</accession>
    <name>W3VMK7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02637</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMK7"/>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="115"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="212"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="370" mass="39628" checksum="E23A008D7E255776" modified="2014-03-19" version="1">MSQSISASSGSSSAAVKAKPKPYPFYLGGCAASIAALFTHPLDLTKTRMQTASARQGMLSLLLSTFRREGVRGLYVGLTASLLRQMTYSVTRFGAYDKLKELTLQNNGGRPLGMVQMALCASAAGAAGGLAGNPADILLVRMTSDVNKPKEQRYNYRNAISGLVRMTKDEGIASLFRGLGPNTVRAVLMNASQLATYDVFKNALLGTGYFNEGTTLHFSASFMAGTVATTVCSPADVIKSRVMNARGSGDGIVKTLRKDVAKEGVGFLFRGWTPAWMRLSPNTIIVFVVLEKLRLLYNNVESRIVPKGFLSGPGGRPSQPKQNFLLSFINTQILAPQHRAGNISIAWGVSVFVAGIVAARNFGDLITPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMN5</accession>
    <name>W3VMN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMN5"/>
    <dbReference type="HOGENOM" id="CLU_027009_1_0_1"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="481" mass="51617" checksum="3907686AE022EF34" modified="2014-03-19" version="1">MNSKAAQERQQRILLDLVRQPGNDVCADCKGRAPRWASWNLGIFICVQCAGVHRKMGVHISKVKSITLDTWTREQVDRMKEMGNLKSNRIFNPDEMRNRPPTNMEESERDSELEKYIRRKYEFRRFMEGRPPPVPTKDATFLTSPPASSGRSRSPVPGVSEQRNLAQGSSIARSRTAPIPSTWSEAQRRVGANAPPLPPSTKAFALPTAAASSQPTLQLPSGVVPQRTSSALDGRNGSSSAASRPAGGASAQSNVFDDLISLGEPSSTPTTQQPALQMNPWAAMQAQQQAVLSAPAIQEPSGNFWSASSSGGGASPASPFGVSPSGGTSLGAMRAMPQHASTLPVATQPQGLGGVSPGMLSPGGMFPQYQQQRSASLGSMAFSTSPIASPGYASSNPFNTMQYASTVPQQQSQQLGQAAFGQQTMAAPFYGQQVQQQAQPQQQGQFGQFHSSMMPNAYGQSQQQPFMQQNTQHSTQFGNMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN25</accession>
    <name>W3VN25_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02833</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN25"/>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="10">
        <location>
            <begin position="293"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="7">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="414" mass="44360" checksum="52896F81B0F04541" modified="2014-03-19" version="1">MAFRSSLVARQGLQSLLQKRADDVVFTTALRTPIARMKKGFKDAYPEELLAHVLQRTRERLEARGVDKSIIEDVCTGTVLMELGGAKSGRMAALHAGMPITSAYKTVNRQCASSLQSITDIANAIRAGEIQCGIAAGVESMTRNYGSRAIPVDLSPWLKESDSVDARDCILPMGETSERVADKWNISRERQDQFAADSHRKAEAAQQDGRLASEIEPIEVRWIDPETGKEGRKLVSKDEGIRPGTTAESLGKLKPVFRSDGKSTAGNSSQVSDGAVALTMARRDVAEAAGMEILGRWVGTATKGVKPDVMGIGPAEAVPKLLERFQLKTDDIDLWELNEAFASQSLMVMDTLKLDAAKVNPKGGAIALGHPLGASGGRLVTSLLAELRRTGQQVGVATLCCGTGYGKASLIVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN80</accession>
    <name>W3VN80_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN80"/>
    <dbReference type="HOGENOM" id="CLU_070631_2_0_1"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833381" description="Sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="151"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="283" mass="30535" checksum="776F191472F313C6" modified="2014-03-19" version="1">MVSRFFQLVLLAGMILLIPSFLYLSHPAQPVLIDPQTGLAYSSDSILQSAQGGTNPLAQVSQGNGAEQAHLWNGWNWHDATANVGSGVHKVEDQVKGFIDHWKPTASSSTTKQDSTSGGQDAKTNPAISPATGAGKDTERVEGVIMPKMGNATAKAALGRSTWHFLHTMTLRFPDQPTKLESETLRTFFLNFAQLYPCGECAHHFQQLLKELPPQVGSRKSASLWLCALHNEVNKSLGKDEFPCDQLDSTYDCGCGDDPNAAKNATSTAPPQPATTQNVTPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNB3</accession>
    <name>W3VNB3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNB3"/>
    <dbReference type="HOGENOM" id="CLU_694688_0_0_1"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="134"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="397" mass="41840" checksum="5CC0451066B1FF8C" modified="2014-03-19" version="1">MQQLLPTSQAGDRPAGQSSAVSTGAASGSGTVKGVGGGHTRQGTDATQDGPRPLQLPEHFSQEVYDRAVALTASAFHNVMQQQHQHEQAATGERSHLRHPVGGGAAQKHVSMHEEEEAQGHGGHDAPSWSRGTSLTVLLSCTVLYAIIAEILVDVVDVVLDGSGIDEKFLGITLFALVPNTTEFMNAMSFAINGNIALSMEIGSAYALQVCLIQIPAMVVFSAYYNAGIADDNLIHRSFTLIFPRWDVIAIIFSVFLLTYTYIESRSNYYRGTICILSYMVLVAGFYFAPATGDVEDPGDDNRDPTVGPAAFMAAAGIVGGAVKDKLTSFAVADGRFGASPAGWTRASGVAALQAAKSAAGHAGTAAALVLPEWPNSLPSLDVGAWAYALWASLWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VND5</accession>
    <name>W3VND5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VND5"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="595" mass="63144" checksum="C9C6A90E5FF5F2E1" modified="2014-03-19" version="1">MPGASETTPLRSSPPRNCTDPAKNGQYGAVPDQAGARAGAGPSAADAPEPEHPQGFKFAVIIASLWVVLFMAALDGTIVVTLISSISSSFKASEKSGWLSASYLLSVCAFSSIYGRMSDIIGRKGALLVALAFFTSGTCLCALATSMDALLVARFIAGIGGGGLLTTSSICMTDLVPLRKRGVWQGVTNVLFGSASALGGPLGGFINDAFGWRTAFGFQVPFLLAGGVCIATFVNIPLPSSGQDWKQKLGRIDYLGSLGLISTSTCLLLAMSFLSGSLLPFSNPLVWGFLLASFVTAVLFVLVEGWVVREPVMPLSLLTRRSPALIGASYFIGSFAHFGTIFHFPLWFQSVRLQSASQAGMHLIPISFAAAAGSLWAGLYMKRTGRYWHANIFCCALNIVSTAYGASWNKGTSAWEEYLTFVPQAFGTSAIFTFMLIALIASVSKDKAAVATGTVYLFRSLGQVMGVSLSTAMFQMLLQSQMHVNITPELLPHPQDGQRGVEKLISALRHDASLVPTLQPAALRHAAQLSYMNAIKWIFVLVTALNVLYLAVCSGVEEQALPDKAPNTAVADDTDPSPPADQSDALRARQNDSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNM5</accession>
    <name>W3VNM5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03474</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNM5"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_3_1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="182"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="439"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="495" mass="54622" checksum="7CC0CA0F7B6C0C2E" modified="2014-03-19" version="1">MVHPFSPLHQTANNGPLRITTAFSIITHHSGDPPPRSLDRPSATVSSLKRKASGDLASARQRKPAASPVLAPSQLANRHGSGHHDHRTSACSIVSVDMSALPQTADYSATHEAAVAAAAAAAASAASAASSSRPTPDASKTAPLPAHVASANSTGTYSSASLPLAIAAQQRKLSGRYALADFAVERTLGTGSFGRVHLVRSRHNHRFYAIKVLRKEQVVKMKQVEHTNSERAILSIVRHPFLVNLWGTFKDSTFLYMVMDYVPGGELFTLLRKSQRFPHPVAKFYAAEVALAIDYLHQNNIIYRDLKPENILLSADGHLKITDFGFAKYVPDVTWTLCGTPDYLAPEIVSSKGYNKSVDWWALGVLLYEMLAGHPPFFTEDGNPIKLYEKIIACKVRFPPYFETGVKDLLKNLLTADLSKRFGNLHRGSKDIFGHMWFAEVDWDRLYKREIPAPYLPTVTADGDSSQFERYPENDVSEYSRTDLPDNLGHLFPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNN3</accession>
    <name>W3VNN3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNN3"/>
    <dbReference type="HOGENOM" id="CLU_010867_1_0_1"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="770"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="73"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="273"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="876" mass="96871" checksum="1F2F0D093C8A8188" modified="2014-03-19" version="1">MNGIKHDTPHGASAAANAPSNLSEKALPPIQGALHSAQKAAKDAVGSARDATSSSSLTTEYPVPQSHPDSQIADYVLVFQHIAKKYLRSSTKVPAAERSKIAAEYDALVQRIRSTGLHVTSREGSKGSGQILLFVKADSQLLHQLARQEALSDYLHGVLSVQPPPPRSSSLAETSSKQPQPSSLHLTPASRLRLVDSLLTLPSLASHAVKNASGSSQVPSGAGLRLGLKEFPHLVDMSAIHDPAYNSAWMKRWSHTSPAKLFSGIGLADLDSIREHFGEDVALYFGFLNFYFQALAPAALLGLTFWLLGRPFSPVYSLGLVSWSCLFVELWRMKERKLAVRWGTLGVSQVDRRRHDFVPRTTRIDPATEEPEEVFEWWRRELRVILSLPIVAFFASVLAATMTLMFVVEIFVTQLYHGPLKQAVPFIPTALLVVAVPQIIAAWQATAVAITKWENHHSAKSFDYSLTLKRFAMQAITAYGALTLSAYIYIPFGESIMETMVQRGFFRDSIQQAIRTGNISPKGIDFHINPDRMHTQLFAVSVTSQFVNAFTELALPVLMRKFAEWREERAAQKNADGSSQRQPQRQDSASSSAPSSGDATPLEPGAPDSGREESERRFVSRVRKELQLPPYDLFGDYAEMATQFGYITLWSVVWPLSPVMGFVNNFFELRSDAAKISVNNRRPVPVRAETIGPWLEAFGFIAWFSALNNAALVYLFQQSEHAHLEGHSRYETTMRTHLHPSRANLTLADDAQSRFSFSRLVPSHIPTSGAAGAIVAAVLVALLAEHVYALVRSGIRHILERLIWRGSHEEMVVRRREWVLRVETLKSHVHGQIDVAEGGLESIRESLSGDVRSAAGFWSKDKDVGATAIHNSGKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNU5</accession>
    <name>W3VNU5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNU5"/>
    <dbReference type="HOGENOM" id="CLU_025642_0_0_1"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF20">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="589" mass="63341" checksum="76B4FD7DE2C6283A" modified="2014-03-19" version="1">MINTPLTEKLGLRVPLVQGGMQWVGTPALAAAVSNAGALGTLTALTQPSPEALRKAIRETKSLISEDIRKEREGKYGSFAVNITLLPSINPPDYVGYAKAALEEGVRIFETAGNNPGEVIKVVKAAGAYVIHKCTAVRHARSAERLGADMLSIDGFECAGHPGEDDIGGLVLMARAAEELKIPFIASGGIANGQGLASALALGAVGANMGTRFMCTKEAEIHDNIKRAIVESDERNTTHIFRTLRNTARVFNDEPRDSNRSSSDQSTAGAVTAEPGTVDQPGHDPNKPPDPKRASQEREIELRRQATKEGAVELLGTRDPDSYALQEEHQRKWNAWGLAKSYLNDEIDHTAANVPLAWQAFLTGMVDMLLYSRSQVWLGFQTGNMVQFSSNIAQLIIPGVERQPLLTLLRILSVIGFFLGSLVGFQFGRRIGHQKRSWLILSSVIQSAFLFGGAGILLSRPKNELPSFDWYPGVIVLVAFSMGMQSILAQKLVSPAFATTVAFTATLTQIASDPYLFHLLPSEKTRGRDRRMLAVLALCVGAGVGESLLHTSANLSGGIAISAGFKLVLALLWLVPEGKKSNTAKGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNV9</accession>
    <name>W3VNV9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RPA43 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNV9"/>
    <dbReference type="HOGENOM" id="CLU_050548_0_0_1"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="6">
        <location>
            <begin position="140"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="352" mass="37966" checksum="95E24737797C306E" modified="2014-03-19" version="1">MSKDGKTKTKDKSKRRESKSGSEPRKSRKSSSSSSTLPLTVVEDGAASASSTASGSRTVTSAFETMYPVLNLPIPPVWSNDPYAAFSDLMDTLVMRHVPQLSGVLITHSPTRFLQDTALFSADSAFATAAVGFECVVWRPKIGQMLEGTICLSSPSHVSLLLYGLFNASIPASHLPEGDWEFVLNDAEAGSNDHGLGYWQSKSDGSRLGGQNGTLAFTVISLTVANHMLSLHGSLLPDPFKGPPPTLDRSYLKKSLLPNQLGLATPSARPTTQTAESPAPTPPRRVRWQDQDNSDTDQDQPDLSALETPQIVKAEPPSIDSSAKPASEKHKRKSSSTKSPPDVREKKRRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNY2</accession>
    <name>W3VNY2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_03119</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNY2"/>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="72"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="335"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS62492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="58647" checksum="571ED0FCF9308C9E" modified="2014-03-19" version="1">MPPAATGASSSATSSTMASSKASASAVEEIAKSASEPPKHTSFSSIGISPMLIRSLASLQIKVPTPIQSLTIPSVLEGRDLVGGAQTGSGKTLCFALPILNRLIKDMVGGFAVILTPTRELGVQLHEQFVAVGEGARMGLRCALVLGGMDMMKQASELASMRPHVIVATPGRLVDHLRSGGGEEWGLRRCRFLVLDEADRLLTDTFKPELDYLYSVLPSPKTLQTLLFTATLTPEVEEFAKSKRPEGKLAPMVCKIEMDTKTPETLEQRYVFVPSHIREPYLYHIMRHPPIKPSSERVRKLKAKREAERERRAENDRKKGKRPRAHHGSDSEDSDDEGAGLFLPATIIFTARCKTAATLSGMLSELGIPNVSLHSHLRQSERSDNLQAFRAQHVPVLIATDVGSRGLDIPDVEMVVNWDLPSAWQDYVHRVGRTARNGKRGFAISFITERDIDVVHSIEAKINTKLTELEGIEDEDKILEKLNTVATAKRVATMAMHDAKFGERQQRNYEKKLAKQKADKRAAKAARKDNPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP08</accession>
    <name>W3VP08_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01686</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP08"/>
    <dbReference type="HOGENOM" id="CLU_027975_0_0_1"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="660" mass="70729" checksum="25510C2E2C9B64F2" modified="2014-03-19" version="1">MSKPTQRGDGPSSSRTPRVAFPTPRSRPTSIVDTTAPSVEASTEAILSTSPASSTISAGGSPHKHTQTAADRLASAQAKDAAAAAKSHRSRTSSSTSRSSMEGARPKLPSLLQTTTTRSAATPTTSNPLDLLSTDKPKEDKTKSASDTRSSVDGSSQPTSRRGSRDVMRTVDAKVAGSSQVKTVSKPIPNAPPLVALLSDSKVSHLIKQGAEAKVYISRITGNNIPTWPQPRSASSTAPNANAPQPVLLKWRFPKTYRHPTLSNSITASRTIMEARALLRCAKAGVAVPAVRCVDEKEGILGLELIAGKSVREWLGGGAEGEDEEIVEANDTDAAAVDDDEVLSEAEQLKLMRLIGRQLAVMHEADIIHGDLTTSNMMLRPAAASGSAESAAQVDLDKDEVVLFDFGLSSVSAFAEDKAVDLYVLERAFASTHPASEGLYQTILDSYAEEVTARSSGKNRGRGGKLSKWEETRRKLEEVRLRGRKRSMVGSALWQDNWNRRVAVNWELAIHVECHGLVAAVWALPSLAGSFLRLRPTDALRLLPAVRGSTRRTSGVDGGEWHALASRMDSELDHIGSATLLSSHLPHESCVRTPPTQARPLMSLVLAPFQAKTLSVPLARPLERVLDRALTAALCTVDRFLPATSSPSQPYALRAKRKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP44</accession>
    <name>W3VP44_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP44"/>
    <dbReference type="HOGENOM" id="CLU_006249_2_0_1"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="419"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="821" mass="89293" checksum="8F04C4C274FFCF1F" modified="2014-03-19" version="1">MFKAIFSSSSSSKEQNSKSDSRPSSASSSKHKQSASPSSSPTMDSLPLLPSRASSSAMAAWTIPPFPHPLPERRIGILPTEQGLLVYPRSSTHVAGNRHHPIHHVKASTAAAPAANSSNRPYGSGDGFKVATIGASHAPSSSTSAAPVAATGALPSLTSLDVGFLIDWTREAKITPLAPPAWSSLLDSASSDEPTLECSGIIGLSCFFNSSYLFVITDSKLIGHYFHDTRPIYCCTGVLAIPLLQQEATQAIRAQLTKQGSPPTPSVQSSSHRDDADVSDSKDQSDSESEGDTESSESDYDDVETPAAIPREPFFSSLPASQRSDTLRVPKSRPWLTRAARAVSDSRIETISEDADTQAKLADASVHAVDMTDEPEVIPIPDPVVDAEVHDTSAVAATPDEQWHAAKQAELEDKAVRETAKYWARGEFWFSYDFDLTTSLQNKRRALDKSARSDSGAAPRSMPRPLHPTQGSASDASDSTTHFPLLAEPYPNLPLWRRADRRFWHNEHMSRDFVHAGLHAYILPVMQGYLQTVSLPVRPQDAPEAYTASTEAKVDEPVVRCQLMVISRRSKERAGLRYQRRGINEAGQVANFVETEQLVYVLRSRAGVASASEVVADALSFVQIRGSIPLYWSQSPFSLKPPPVLERTEVENLDASRKHFGVQVDRYGSITCINLAEQGGKEGAISKAYRAAAEKLRDEDVAGGSGKTWDRKKVHYVDFDFHKECSGMRFENVAKLIAQMEPTLAQMKYYHHRSVGAAKADVEVLNMQTGVFRVSCLDCLDRTNVVQSAFARHVLTGQFAKLGIRVGDSVSSSASAAETAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP78</accession>
    <name>W3VP78_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP78"/>
    <dbReference type="HOGENOM" id="CLU_090468_0_1_1"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="122"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="219" mass="24316" checksum="FC271C4F51D9C2E0" modified="2014-03-19" version="1">MSLFKKFEPKPDLGPATALKSSVRRVIRQKLCEQYPVLAEEEGALLEAAWPNKASVTTVKFAREHVQMLISDKQVLFFQHYDDWYLPSLRLLHKFPEMLPSVQVDRGAINLRLLHKFPEMLPSVQVDRGAIKFVLSGANVMSPGLVSAGGKLPDPSKGEQPIKEGECVAIRAQGKNEILAVGVMKMDSEQVRKTGKGIAIENIHYLGDDLWLTLSKGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP81</accession>
    <name>W3VP81_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP81"/>
    <dbReference type="HOGENOM" id="CLU_038395_3_0_1"/>
    <dbReference type="OrthoDB" id="4239773at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13740">
        <property type="entry name" value="ACT_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="4">
        <location>
            <begin position="234"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="533" mass="57751" checksum="4AE0B98821B30EC0" modified="2014-03-19" version="1">MLTGKLSMQVALSVVPIGEHGKQAGLAGLCDSAQHGRRKQKSSQAIWLVRSDEQLGSGENSGALPSHWAAGNPGEKEEMPFFFGQEEARCNSHPPFGGADQLVFAPITSKLSPLRLSHAGLTLPLNRIRRPFAPYFRAPSMFNLVGSKLASSALASARTTLPVPTSFNSLRLGRQSFASPAVAISTRGLRSLADLESMTTPQQTAAAAAGSHSILPSKIRPKQPASALPPPSIILTLSGPDGPGIVHRISGFLARRNMNIMDSAQFGDPTTGTFFMRVHASEPEPDNGSHPDPKASDYAQNRQAFLAKVKAEFEEEFATAAEVSVKIFGAEEKPRTLIMVSKIGHCLNDLLFRLSNNTLPITVPLIISNHADYEPLARANGIPFYHLPINAAEGKTKEWQEAEMVKLAKQYDIDMIVLARYMQILSPQLCSLFSGRIINIHHSFLPSFKGAKPYHQAFERGVKLIGATAHFVTADLDEGPIIEQAVERVDHAMTPADLVQAGSDVEARVLARAVKWTAERRVLLNGAKTVVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPJ1</accession>
    <name>W3VPJ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPJ1"/>
    <dbReference type="HOGENOM" id="CLU_1355498_0_0_1"/>
    <dbReference type="OrthoDB" id="2937326at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="206" mass="22956" checksum="28928C48280F8C4E" modified="2014-03-19" version="1">MPPSTASLDPLPDHWYYFFGVLEPLSVLAGSYYALVLPERYHHELIPPAFLSSSKLQSGLQNAGVLSDPARMALGQLGSCYFLIMLNSALMFYALRKWLRGTNDVALERILRYLFFVLGAADWTHIGLTIWLLPNGPPTRTGLVGVHKATAVDKFRLLANPASWNSLLFGNIMITFILFCFRVLWWTGVARGSAIRAVTTPRAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPQ8</accession>
    <name>W3VPQ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Aminomethyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_01979</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="4 12"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPQ8"/>
    <dbReference type="HOGENOM" id="CLU_007884_10_0_1"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="13">
        <location>
            <begin position="80"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="14">
        <location>
            <begin position="364"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="448" mass="47707" checksum="DD2AB559E4325CA3" modified="2014-03-19" version="1">MLASRPVSAASAVLRTAARRQAAPRWQQLVQHATPRTTASTAARPTVAVAGRTAVRPMHSTAVRSADASAGADSLSKTGLYDFHVKNGGKMVPFGGYLMPLTYGDVGQVASHHHVRTHAGLFDVGHMVQHKFEGAGALKFLQHLTPASLTSMPAFSSTLSVLLSEDGGILDDLIITKHADDSFYVVTNAGCRTEDLAWFKKQLDAWTGERVQHQVMDGWGLLALQGPTAAQVLSKLAGSFDLSTLTFGKSAFVPLNIGGENVECHVARAGYTGEDGFEISIPPASTEKVAETLLADSEVQLAGLAARDSLRLEAGMCLYGHDLDATVSPIEAALAWCVGKDRRAAGDFLGAERVLQELKEGPPRRRVGLFVDGGIAREGAEIFSPEGAVVGRVTSGIPSPTLGKNIAMALVQNGHHKKGTKLKVEIRKKLRDAEVAKMPFVESKFFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPR8</accession>
    <name>W3VPR8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPR8"/>
    <dbReference type="HOGENOM" id="CLU_268977_0_0_1"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="549"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1096" mass="116167" checksum="B32421F984C7662C" modified="2014-03-19" version="1">MQSQHAAHRWTDSFGWDEGLARAVSCASDARVYSSVELHRPPAGLSLHAVEQRPRLAWKELSRQLWRKGDFGFRAAPPPSAPLRHCEGQKARARVPSRESRGTLTPVMPAYHGSLSASNTGDGDLGLLAMQSSSPSTSFEPADHADARAAALTAIPAYPGTPPAEPPAAASSFTHSSASSPGAQLQPALAPNATSSAPPSAFAALSLEDELGQPNTSRSDLAPATSPPSTLPVSHRNRQHLHTNSHSSSSDAYTSAAESPASDRAHRNPPAPSRAIELASAAPLQAVTSSSTPPNAPPASVSQQSIASVSTITQARLPTSRSLASHVSSADKHALSLEQELDADRDAESSSNAHDSDTRTTHSAALARSSRRSRRSGLPPPQDRLPVGEGGPHAPPRNASFRDASKRLSVGAGYGDLGVDAYAPSGIAPSSPSMTSFLDLDSPRTSESSTTGRYNVPGRRTSLHAPSPRTSTFPVPPGSAPAPPSTSSDSRRQTGQKSSRPGSSASKTARAATQSSASPAASVSTHSPGTSTPASSLKLDREAMQRWVLSVGCVNFDLELGPDLEFLYPPLGISREERDNIAFSSFPDTSIFDDGSLVFSWRVREVPLDSSGSEPPTIKSIGDALQPAATAADEETPRPSMNKAALQNALAKAGKKPPTGNLSASGNRELPEPLIGPEGPLLASVPATSLFDTFKEALGDLWLLWECVLLAEPILVIAPEPKIASEAVWHMLDLIRPIPYAGDFRPYFHIHDYDFRTLVTKNKPQAGTLIAATNPFFATACGHWPHVLRVGKAAVKLITFKHNPNGGAGGAKKGPTVGGGIGGGHGAGGGGPDHIPGFTTKRKRRISKDRQLLKRLQDLAAAAAKNGGSDEAVQAACQAANVTMRRYFADLTERFLAPLNRYVASLVPASFDLGSPSEVPKIRPFNTTDFLASLKAHGTPLAIRSRSLPTGASVRQSVYVDFLRCPNFSLWLHSRVAAAEEEQRRRYIASLMQGDVTAFGSTRGEIETIDLYSRLVEEIRLVDVQLTTPTEPGPGSRWRTDKPAPAKDGSATPNKAVVGNTTEKRLRDQKAKLMQQLDRLCQTLPADLRSSLRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPU2</accession>
    <name>W3VPU2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_01801</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPU2"/>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_1"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="94"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="392"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS63510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="564" mass="63963" checksum="F8CED01BAE243F8F" modified="2014-03-19" version="1">MGASPNTAELLLRVCADIAAQLVDAHDRSASVSLNHIRTTTCKRYGFNGVPRLTDIIAAIPEAYRKALVPALKAKPVRSASGIAVVAVMCKPHRCPHIALTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYEQSKNRVQQLRELGHSVDKVEYIIMGGTFMSLSETYRNQFIAQLHNALSGFNGNDVDEAVRYSERALTKCIGITIETRPDYCLRPHLSQMLRYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCETFQLAKDAGYKIVAHMMPDLPNVGVERDMEQFKEYFENPAFRTDGLKLYPTLVIRGTGLYELWRTGRYKNYTPSFLVDLIARILALVPPWTRVYRVQRDIPMPLVSSGVENGNLRELALERMRDFGVSCRDVRYREVGLHEIHTKVRPEEVEFIRRDYTANGGWESFLSYEDPEKDILIALLRLRKCSKAGTYRPELTKDGQCSIVRELHTYGSAVPIHSRDPTKFQHQGFGTLLMEQAERIARDEHGSCKLAVISGVGTRDYYRRLGYELEGPYMVKMLTDQDDTDHAAEQDAQDFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPZ5</accession>
    <name>W3VPZ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPZ5"/>
    <dbReference type="HOGENOM" id="CLU_074848_2_1_1"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834785" description="Synaptobrevin homolog YKT6" evidence="10">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="8"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="158"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="218" mass="24109" checksum="51E68737A0A9C5F7" modified="2014-03-19" version="1">MQIYGLLVLASPPGAGAVPLTTAWELGSFSWLQRGTVQDMMGFMARTVAERTQPTQRQSVQENSYVAHVHARPASDGVVGVLITDTEYPVRVAFSLLNKTLDEFVIKVPKSQWETRVNAITTGSATAPPKGEALLGISAFPQSVDYVKRYQDPRQADTIMKVQQELDETKIVLHKTIDSVLQRGEDLDKLVEKSGTLSEQSKMFYKTAKKQNSCCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQF4</accession>
    <name>W3VQF4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQF4"/>
    <dbReference type="HOGENOM" id="CLU_427109_0_0_1"/>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="75736" checksum="DFCA21D623EFFD33" modified="2014-03-19" version="1">MGVKGLTSFVKQIQHVVSEEVTIPTKSDGDAASSSSGASTPTGPLVVDGWAWIYRAYLDHFVESLRGGDYVGYNLYVRHFVKALRQASLEPIFVFDGPYLPLKIPTVLSRLGETASNNSAFMRSSSRSKPGFQVSMGVFPPLLYDCTLDALRQCQVQIVVEQIEADSAVAETADRMSGWAVSNDSDFFVLCARGSQCRGYVPIDSLAYLVQPPATQQDKAQGAADAAASEAFEDDGFAQVGKGGKAKGRRGDKVAVPAQAQLQTLNRPPQTAADGVLSGIRFTSYSSVKLAAALGIPPSMLPLLAALVGNDYTASIQRRILDPALPYGPQRITFIANAIKTESLRMASSGNRTPALRSGAATPSASRTGLGRSGASWGALSARGGGSAMTSATATPIGDTMYPKLDEALAALALNDPVRFMVQSVIDRILTGVAQHTRDAYVTSGEQDQLVDAVIDSVATYSLLSDASAVHRSTPSADFFAVAQGDKPAFRKGLQKYRKAYDDGHFDRMLVESLTQRICTNRMGAEDPDQKSIQSTHARDLRSCTTSTLFASFGMGWARETLEEPLPPSAPAADDELGDGSHTGAIPILAGPGPNKVNWDEEGDPDELIPVQTPPSSFGSSMYQGDDGDEDDEEDEDEVKSRPGSAAGFVDDEEEGKVKPPPAVSDYCRKGDRYVADLAPILSFDALVAKQRGELGIEPPQALRKYLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQI5</accession>
    <name>W3VQI5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_02257</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQI5"/>
    <dbReference type="HOGENOM" id="CLU_046747_0_0_1"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="88"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="382" mass="42148" checksum="2CBC031F6E68BCFC" modified="2014-03-19" version="1">MVVATARALKPFSAAAAVSTARAATASTISTSAMAPVPSSSSTYTIRAVAAFARNLLRFGCRNVTVRGLDRFLAQLHSAERTASSRGLLTYCNHISVLDEPTIWGTLPASTFRDPRTVRWTLGASDIMFTNSMLARFFRNGQCIETHRGGGIYQKAIDEAISKLNTANWVHLFPEGYVNVSTSSRLRRFKWGIARMLLEAERLPTVVPIWITGFDRMMPEPRAKPKWLPRFGNDVSITFGEPVTDQLAPVVEAIRATNDIAPQHLLPEELRFDPASINHADPDAVIADRSVPTQLATEWNTASLFQRPLEAGDDSRLALARSQLAALLRYHLGLVAVQQRTADAYPNPQEDAQLVHTESLNPQKQHAQNNVLRDGQRKKTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQJ7</accession>
    <name>W3VQJ7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQJ7"/>
    <dbReference type="HOGENOM" id="CLU_576359_0_0_1"/>
    <dbReference type="OrthoDB" id="2550388at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="474" mass="52400" checksum="5F4BF7C01B60E479" modified="2014-03-19" version="1">MPPLPLHDSYPPSGSGYRPLATGDDDYEEQAPPPDTSRLRTFVVSPYQSPANDPSQILRAFLTDTRTPGEAHATKNVALRVRFRSRGTETTVDLPVSSLTEQDALPFALADDVPCRRGIMRRRAWNQRLRCMADRLAGRSSTSSKQMAQEQDELSVWDRTQGKSLPASDEAKQRYHRRLETGLVPPWIPLDEDSGSLSQPQAAQEAENDENADDKLDLTKLFTGSGDVDLGIFFRRSRRRRATRLVSIALQEALERFADDRHFSKRFVCRNTAWGWDLPRLKESLRSLAAQAAEGKGKAPAHAADEAGGADVDIEVVGMEEGPVYHVVWAPIALLAARCPGLVESRVSAISLALLATFLVAATLLGALSGILILAIMVVVGAWSTMMWLVATKDECVYDGIGTAWSLAPRWQTIDADPSWDMQRARASLPPDSAGDQVQLERRGNAWCVRRGIDQDEWVALQRDRILHALTART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQK8</accession>
    <name>W3VQK8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQK8"/>
    <dbReference type="HOGENOM" id="CLU_078855_2_0_1"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833296" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="229" mass="23088" checksum="307DC2451B7101F3" modified="2014-03-19" version="1">MVATKVATLAVLVLAAADAAVSTIVITKPVASTTGHGGKRLSVEWNDDGKSPSRRDWGRVNIYLATGSRDVQYKLQTLDTNVSYDQGQARYSIDANAGPNGGYYFLRFEGTNTSAAGGIPPMAFSARFTLDQMSGNFNSTIMSQVSGVSGTGQLTAAAATASATASSAPSFFSFTSTKSAAATSSTASAASAQATSIKSSSAAAPNANNKLAGFASALVGLAAVGAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQM4</accession>
    <name>W3VQM4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQM4"/>
    <dbReference type="HOGENOM" id="CLU_1098887_0_0_1"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="253" mass="27200" checksum="37C2B46E5B1B017E" modified="2014-03-19" version="1">MAYAPNAAGILHAGILLRGVGVTVNPQLSLFGVASERDRRKLRSTAASRHPALPCFASGRGQSARAGGWLTQPGYLASPPLEACFSPRFRRHSATCSATREAFGILIGGRKPSKNLGPGEHMIYGKHVRRFTACIIANAALARRHWEASQHCSIPSEMDADAHAGSSTASPIVASDDFTESAAWTAETEISANEVVEKEKLVREIMARQDGLRALLSRVSSVKEDCKKAEADNEMLQTYIDSVTKSLAAKERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQR3</accession>
    <name>W3VQR3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQR3"/>
    <dbReference type="HOGENOM" id="CLU_099529_2_0_1"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="186" mass="20343" checksum="720FA9FACA72BA1A" modified="2014-03-19" version="1">MSWFSKGGNASGGGASSAFAGTGPSRWINMDTNQIKNMGGELTGESDAFSKTFGIELTRQQRLIGFAACMLGGFVISLLGTVLLVTGSWAIFVVLYSVGVLVSLTGTGFLIGFMKQFKQMFKPVRITFTLVMIVAFIMVWVSVFAIGSTVLAIIFVIVLYVAFLLYSLSYIPWCIDFIKRMFSRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQV1</accession>
    <name>W3VQV1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear receptor co-repressor/HDAC3 complex subunit TBLR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQV1"/>
    <dbReference type="HOGENOM" id="CLU_007609_1_0_1"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001867">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000003">
        <property type="entry name" value="Related to Nuclear receptor co-repressor/HDAC3 complex subunit TBLR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="524"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="680"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="731"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="839"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="92162" checksum="4E0D86B7CA42B0C5" modified="2014-03-19" version="1">MAPLCTSEEVNLLVYHYLKESGFHHASFSLRHESRLDDTPLSKEAIVEPGQLVRFLQKGLLYASVEAHVADDGSEKPCSAAFHLIGPPHVCDGNPRPTPPPVPATRLSPEPDPFAALQPRSDHKEAATQTPAPLATANGVHLAKASTTSSIRSADDSDRSSRVASSSKKKIEDVAEDDNASSASKSKDAKRKASASVSSEADRDDKRLRTSEATAKQDADALRVDGEHASSHKDRRNGDVTSRSASPAAEKKAAVQEQRSKDRESSSGKKKKGGKSAAGENGEGSKKRSDKEGSSRGKDPKAPIPQPKGDNFVEDGQITTLSGHTGEVFISAWNPTVPNMLASGGGDATVRIWEVPEQAGESPEAPTICKHLPATQSKDISTLDWNPDGTLLASGSYDGIVRLWTPQGDLHLVMSMHQGPVISVRWNRKGNMLLTGSADGTIIVWDLNSGKPRHTFPLHSDSVLDVEWLSTADGSLKPNSSSDVPPPMPHGLSPSVADTYFASCSADNSITLCKLGEPKPVKTFKGHTDEVNAIRFDPSQTLLASVSDDMTAKIWALDIGANAGGAASTISSGGDNLRKRASQRRGGSAHLDGMDVDEEPTPRPNEDGSGDRDREKDRATPGTASGNAASAAAPAASNKEASSPAPGSNGHAGSAANHTTSSALIATTAKGPNKGLRLTLSGHTKELYALAWCPTGPGSANPDQPRMLATSSFDWTARLWNADTGECLRVIDAHEDNVYTLRFSPCARYLATGGIDKKVVISRVDNGALVQQYVGGGAIFDIAWKDLHDTVETKQEEGEKEEGTADQPPRLAKRHQLAISQADRKLTVLNLADLDSVKSTATFKAPPPAEAKSEASTAAEKPPKKQARGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR12</accession>
    <name>W3VR12_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02351</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR12"/>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_1"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000069">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="316"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="634"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="686" mass="75116" checksum="99B24CB2BEA2AE42" modified="2014-03-19" version="1">MKYIVVSGGVISGIGKGVIASSTGLLLKTLGLRVTAIKVDPYMNIDAGTMSPTEHGEVYVLDDGGEADLDLGNYERYLDVTLSRDNNITTGKIYREVIEKERKGDYLGKTVQIVPHLTNAIQDWIERVAQRPVDGSGESPEVCIIELGGTVGDIESAPFVEAMRQFQFRVGHDNFALIHVSLVPVIGGEQKTKPTQAAIRDLRGLGLVPDMIAARCPVPLEPAVINKLSMFCHVGPEQVMAVHDVSSTYHVPLLLEEQGMVRFFQKRLGLDVNGSIPRPMKEQGRELRTRWRDLTVGHDRMIDKVEIVLVGKYTSLHDSYMSVVKSLEHAALRCHRKLELKWVESSDLEPAAESDNPVKYHQAWQALCSAKGILVPGGFGTRGTEGMISAARWAREKKVPYLGICLGFQIAVIEYVRNVLGIETAGSAELDADCKDPVIIYMPEISKTHLGGTMRLGLRPSIFQKGTEEWSKIHQLYGGQPVVWERHRHRYEVNPEYVERIESAASNPSLAAKAAPQKVPATSPPLPSFTSPRLGYPSAAEAEPAGIDELKFVGRDEKGERMQIAELRNHPYFVGMQAHPEFCSRPLNPSPPFLGFIAASAGLLDEQLAVQKNYVPPHPKSHMISESEMIKRRDAGETDDKPATTPPGAATPTRSLSLNKGTSKPDLAVAARIAAAEKANSAATDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR59</accession>
    <name>W3VR59_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR59"/>
    <dbReference type="HOGENOM" id="CLU_360963_0_0_1"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="775" mass="85153" checksum="E9B86E0D6E4DE968" modified="2014-03-19" version="1">MPARRPSLSASRSTPLLESSASKRAMLASSTVSDEPTRPFNVRRRLRRASQPAGPSQSTLRFRLGALAPEEALAEGFSSATATATATATDSGSSDDEWDATYSDMFSRQRHQSLGSLEYLDLPASLPYSIVSLRAQLLSYLTELEMRAKAFYSMRISRAASDPAAVPCDSTAAASASGNSAVSGQDLPRSDAAALNDGHSAAFFQQLEALREDLRRLVALLPTYPASASSALASRSQTLAQDWERLSSSFSFPISLGNGLRERLPRLPSSSDAARLRAELPSLPSMPSFPQLDLDFAPVLEPLSSHLPSQAYALAAKMQARLETLQESVRNMAWRDCLQSAAADDGQDHTSLAQRFETKLMDLSVRSRARANSFAERAGHAVHEAEEKLYQLAIELARNGQELISYEHLPAFFRNNEHILSGYRFIPVENWRALVRSTFQIHNETGNIHTHLWGLAAIVPLFWPSKGLDEQTTPMDRLVQTVYLLAAAKCLTLSVSWHVMAGCSDRKWFERFACVDYTGIAWLVAASIWTTVYNCFYCQPNLALFYSFTTLVVGLAGAILPWAEWFNRRENKGWRIAVFLTMCFTALAPFSHAAFEHGLAKTMSFFSPIFPSLAFYVGGLIFYATQFPESWKPGRFDTWGHSHQLWHIGIVLAIVFHYRAALLFHANRFEFSCAVPGASMAAGGGAAASVSPSVVQRLLGLLAWTQPLSATGKAAATVTRPIDSMFAKVGGMEGIIGLARADDQVLQWRRLLGKIGNGAVGRGWDALVDWAQNFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRI5</accession>
    <name>W3VRI5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRI5"/>
    <dbReference type="HOGENOM" id="CLU_863620_0_0_1"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834813" evidence="1">
        <location>
            <begin position="19"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="322" mass="35448" checksum="A64F7AA853349CB0" modified="2014-03-19" version="1">MRLHRTLLVATIVPLAAAAAAVPWQPIDPFSPIPPQSTRESLDLNDPAIGVSDLLVYNSSFSEDAVYDALDLDNGDGSGDPDQPGWVDPRTYGGSMLDLVGNGLREPINVIISGKSDKHVLSDLGLKDYIRTIGFSFECLNLHMGNLQRADLGDGKGWVPEMFEYRETGFPGAPGRWVGACWESLYGGNHFRVWKQNGTMANTGAWFLAVSKEKNLKYHHTIDRDGYNVGRDLLVAAAQRGGKWNNVYYKADVEWIDGLLDPGRHGINHNIGQDGRTAVLTVKKVDALSHGFIFWGLEALGNWIAERIAAHLARFLRQIGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRK8</accession>
    <name>W3VRK8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRK8"/>
    <dbReference type="HOGENOM" id="CLU_286544_0_0_1"/>
    <dbReference type="OrthoDB" id="2547857at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1083" mass="119663" checksum="92B9C740FD237635" modified="2014-03-19" version="1">MLRSRIGRLYRGAGTSLRPAPDVARSSAASTTSTLDPKIRHHTLDDVPARRKLSNAAHLRSTFPARNASSISAAAFRSESFFNASQPEEPLSASQPLTEDLVTPQLASERYLPPLADVTFAAHDDEQQALCDALKNLDADNSWTLYLQLGPARHALHPSIIDRLITLQCRKPVRSLPGSRADAQLALRQVCDRVLQLCKDKARCKVGTSAHSSASADREGLSALSPEAALRLLYLLVVEEEQVAASRSAPPPQKRANLSHILQTLWVNLASSSSFAEEHVDIALRGRLAASLARLGSHDAAYRQLEMVVDLAEARGCQQEVDPRPFDQLLSALARQRSNSKRLPKYLPSPIDRPISAPDENDPIIRALRLAVVFEVPVSKANIHKCLQALDSPTLWWLLPFELDSDKRRQSSAIEIPDDRYALKPKWHPWQTSAHGSDVPQDILDTFAERVSLVLAQRGILQPALHVLDGLQSHVAADGKADKRHGTSSNVPDHDLFTVVLERLSDRMATNNIAAGRKSLDIHTTLLLDLQLAVKVYSIAYDSGVDLDPRINEAVIKSFAACVPSSVVDLGPDRARLTKIKANIAERNQSRGSHKMLHSCLRRFTTMVLDRDPDLSKGALRYQAQATLLGLHLRLRDHSFSKKLYQLIRLREPGRELWSKDPESGSLQHVALHPTCRPDSSLFYWLFRESLYAAPEPLFAVQLSLDWLASGNALSAGLMIPFVQTLLRKGLTAEFQRVLHELQRRGTPLPPRLARSLVASLAEAGYPELAVEVANGVSQAAASTAPYRSGHVVAVGSSAEPEPSVLVPALHLMSIALDRSSKMLDSTRLPLVSKVLGLFDEFRLGLTQYLLHTHRQGDDVNQPQGRLPASDIRTAYNAAMRVRLAALPGTESEGWTDTDQEEYTYLQDRASIHGHVESLFAEMAAQEVEPDVHSWTLRITASLYDCLNASNDHKRLVRLKRTIELFEAASQQMPRQDGGRSPWDGSEAVGSNTVTVDSTLVAALMHACRRCSDLDAGMHVYEAYVRLGGLDQRVQEAQLMLLASLGRHGEWQRELKRLEHATDVPFKPSQRIVKQLQALAAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRN5</accession>
    <name>W3VRN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_01122</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRN5"/>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="337"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="407"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="470"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS64283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="776" mass="88864" checksum="D606C3DF47B7F0C2" modified="2014-03-19" version="1">MDASRGQTVRVRRNEQQQQQHAVPPPQHDLAHADDNDDHRKYRSNLHAVSPKVHAHPADTPIAVALFVLAAALRFYSISFPDQVVFDEVHFGKFAAYYLRREFHFDVHPPLAKLINALAGHIAGFDGHFEFDQIGDKYLENNVPYIRMRALPAIIGSLQVPLIYAIMRHSGYAPIIGVFSAALLLFDNAHIAQDRLILLDAPLILFMMLSLYSYIRFYKLRYNEFSLAWWSWLLATGLNLALTMSCKMVGLFTFFTIGAAVLCDLWKLLDIRRGLDMDHVVRHFFARFFALIIFPFGVYLFWFWVHFAILIKSGPGDVFMSSQFQQTLQGNPMLSNARDIQYHDHITLQHKNTKAFLHSHLERYPLKYDDGRISSQGQQVTGYPHNDTNNVWQIIPTRPIPDDQADGRVVKHKDHIRLLHVNTNSYLLTHDVASPLMATNEEFTTTPANDTSRYDDTLFEFQLDESDLPDKSWKSKASWFRLIHVNTRVCMWTHPEPLPDWGFKQQEVNGNKNAMDKTCLWYVDDLVPSPSSPDYEERLKPLPPRKVVRMSFLKKWLELQLQMLQQNAGLTQSHPYATGPINWPFLLQGISFWTQDAGQHQIYMIGNLVSWWGTILSISIFAGVVGADLLARRRGIYPIPSAVRNRLHKSAGFFVAAWACHYVPFFLMSRQLFIHHYLPAHVCACLVAGAVVNFVASETVQFPISPPGPLLRVHDYRARMDNVVPKQARAVMAVIMAALIVCFWWLSPLTYGTPGLTTAEVHARRLLSSWTLHFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS28</accession>
    <name>W3VS28_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS28"/>
    <dbReference type="HOGENOM" id="CLU_009600_9_2_1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="77"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="546" mass="59500" checksum="08B20064F348B16F" modified="2014-03-19" version="1">MTTWQQVAEAKRAQREALLPDAYKVAAEKLPPAGTDSVIDFARTCGVLSEREVEITETDDVSVLLARLASRHYTAVEVLEAFIKRTCVAHQLVNPLTEIHFEDARKWAAELDAELKSTGKVRGPLHGLPMSVKDQFQIAGSDATIGYISYANKPSKSDSVLVDVLKRAGAVPFVKTNLPQTIMYSETSNTLWGTTVNPHNRTLHPGGSSGGEGALVAIKGSPLGVGTDVGGSVRIPATLCGVFGLRPSSHRLPYQGVQNSLLGQITIPSVLGPLSRSLSGLIEFSKAVLAQQPWLQDPQTPSMPWSGERFEHARTQKKLNIGVMWHDGVVKPSPPYERAIKQVLSTLGGHDVIDFEAFRTIEMLEILGDAFCADGGKDIEAAIAPLNEPLGPCFSGIGKREATGYEVWQANKRKLEFQKAYLDHWNATAQRTKDGRPIDVLIVPGFAYTAVPPGNEIYIGYTGIFNVVDYPVVVMPVTKVDPKVDGSAKRTDFLNPDDEKWYALWDAEKLVNAPVGIQIVGRRYEEEAVLGYAEQIWNAFSASKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS44</accession>
    <name>W3VS44_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_01916</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS44"/>
    <dbReference type="HOGENOM" id="CLU_010365_7_2_1"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="316"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS63617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="623" mass="69770" checksum="58714CECF1643301" modified="2014-03-19" version="1">MEHVLVKRHKEVPGCVWQPGMVGPGCRPPSAVKKAAMAGKDSYYEMEKYSRITTWVLLALLGVVMLRHLVASVRHSTRSRLSLAPLSVPGYCTLAALCRGIGYYRPKRIFARNTVLAELISADRFPSLGNIIAMAVPSLGFICWCFAVKPYYRPAAVWGSTPLGVRAGMIANAFFPWLFAFGLKFNPLTFLTGISHEKLQFFHQWMARLILFFSIVHTVPFLWQPVHDGGFSNLKAWYYYDKIWWTGTVALAMLAWLVVSSFGYFRRMSYEFFVLQHVITIILFLVFYFMHTRDLLHSWSWLWPSIGVWGFHVLFKFANSLRISRFTGVPATVTLVDEDESFVRLEVSAPVSWLPGQHFFLRFPTINRSAPYQTHPFTVANLASPDVNMDSHLVFYFKARDGLTRKIWEHLMRQPPVKGKVSATFTVGLDGPYGLPFQPAAYHADLMLAGGVGMTSTLPALMSLCLATRSSRQAFTSRVAVHWAVPSMRLYEAFEPALRPMLEHLRTVGVDASLDVYCRAASSKATTEGTSSEDFSTSASAKSSSSALASFVRIHTVRANVPGIIHSFVDSISSNRTVGVAVCGPASMLSETANTVARLQWSRVMSSSSTLEELYLHTEAFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS49</accession>
    <name>W3VS49_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002853_0_0_1"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF54">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="567"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1648"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1805"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1375"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1672"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1711"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1805"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1825"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1839"/>
            <end position="1849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2000" mass="211628" checksum="BFF9DFB02A660254" modified="2014-03-19" version="1">MEDALSLQKSKAQWLAALDDAIDTFRTLVAESSSKSWKPVSLGGSTPATPSLASTSSFPMTPSQSAASSGASKTAAASRSKKRDSSSLRHVESIEDFDSHTDSPSSAAGASTASPPPQKPSASDPQPFRIGRFRPDQVAVHRRTRKGPDIYRAVSEVAYDGTADLHAFRSVLQTAETRASWDRLVQSAELVEQLDPITRINKVHYRLGWPASPRDAIVINRTLADDATLIDISTSLPRSPDAPSYLRPAPPCVRSHVHLMAWCIQILPPESSSSSSSSTTRSKSTSSSAPLRSLPRIKLSVFWSWDLRGAWMGMPSGGLGMHLPELIKALAFHVQDHSDKIPALTNYGSCVEVLTSTFDPTRDTLATEYAVVEEDAAARQAEDRAEKDLDTVHLLRSRRKLQATVEFLLPSSEGWDVRVQGKGQTLPPAAADADASAEDGPLWRATAERASGSRFTLLSIRHKTLDSPEQLARITVRIQRVAASTELRLNDAPLNVEHVEPRTAAALAQPLLEDTASISEISVATTSTGSAASFNVGTAANASRSGTPNLGSAHQINNQIRRNYIYFTSLLQEPEAKWKPVSDMKGVTVTQLDSIDPTLVVYRAEATFVGVSVWDLFSTIGNAGARAYWDKALDDAVLLTDINELSSLWHTKTKPSWPVSARDTVVIQTAYKSPTSVHIFSFSTDDRAQLPAIPPVESGTIRTQIDLRGWSVEALSPTTVHVTMLEQSDPKGWTSKSATPAAMISAVAGVGEYAIKFGSPPVLTRLLGAKAKVSRYDHEKATFRVEYACDVPLDDDLGDAPNVECEIRCDVETWATSLDLVVDPPPISISCLRRHKLSQGGGGLWLTIEHAVASLEDDSARIIIRRGTSRDKGAVHVNGASIKVDVDELNDEQVQQLSRQKRSKPQRVPLDLINPARKPTEDAAAVTTKTGGTDSSAAGSVESSKEQGARQSAENGNDERQLSDGTSTSAAAGVGAGAATEAKKRERGDSTGQPAAAVPFSDETPRQPMTCALDVLFLLRRIHAERSPDPAGTPAGWALVTERNGLYVRRKLMESISSTVLVQRGDKVVQGLSAEDLLDVVANLRSRKQWDDKIESTTLLESYGDGSFTSFITTKASFPFRGRAFHLASLTARGAPPSSNGATSPGEAPLSSSASSWSGPAVYFHASASFPQQNFGFAPDRLNPNGLPFGKVLIDGWILETLDPYSSTSFQIPSTRCTHVVAVDYAGSLPVAVNTMWNANLPRSVLLVEDYLKARGSIPSVKTPPACLQVLGDGRDEDQGFVWSLKDPQRKNLLVSSSFDPTTRMYVAVSMHRPSPASAAEEVPGLLPAASIVSNGKPRPRSSDASVTKGVAEKLTQAINAAPGTPLLGSAAPPVNSSADQDSSLSRATSMHSITSASAASTASTIRRRPSSIHTDSRNAKDLILMEVEIELRHYHKGYDVQCFSEFAPLDASVSDSATAALPKQDRSAAGGETAASEHDKAPATASRGAETGKPKPPFSLRMAPEKSNDLPVQLKVYDLPPSAVLAATLDPSARPRKHLVRVTVPTTSFLDPVEDPLTGSKPPDTPAWYTSLLERGAVLRLVVKPLKSEGAEADPAGAPRDANGTLVFATPSGKVAVRSGDVKLDIVHVNQTSAMLQREQIGIEPMTQLKRVAPARPRSARKSGLEGAAATKDDGRLPEALRRPVAQRTDLLQPPTAAQADAGKDDAKGAKASAAGGADKAARPAAGVEKSGKAGSLAPSSAAGSANGSAAGSAPPSRAATPSAPTSAGAQIMSMFGSYPLSRLGTGSALASSLTSVSSVTARGSSVASSSSAKTNAEALAASDRAKHPRSADKGDKATATPDAASAAQDERGSAGEVVVEAAASAGSTLAQAAKDAVSALGGVWRSETQFRLSTLVLVAVAAFLVGSLMRSMLAPLDFVLAPTGAPQPAADGDFTQLVRSLRAGEGGNKIDRLVEQLGSAKGEGRVTQMQWTQLRRLVHVPVPALGWDIVLAGVRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS73</accession>
    <name>W3VS73_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS73"/>
    <dbReference type="HOGENOM" id="CLU_2196608_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="112" mass="11865" checksum="B54D164A45C533BB" modified="2014-03-19" version="1">MLGGQVGNIPAGDYACFRLNGDIRTRLQTANDSTKGFVNNAGSMFVVVLNRATQVVELHTDKTGVWVSHPDGSLRDIQLSLRQLAAASAGDENGQSDHQYACNGHGPIALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSB5</accession>
    <name>W3VSB5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSB5"/>
    <dbReference type="HOGENOM" id="CLU_449134_0_0_1"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="608" mass="67991" checksum="E30B66877C56E2B4" modified="2014-03-19" version="1">MQVQGPFAFPVRAADGGGGGTTTDELHVAEQQREAALRALAVRNSPRWLFVAPGASPESEDELKLLLRADFERHHIYWNSIRWHNHLLHHAVVIYTLGARPERLAELFAQHASFARPLMAPLAQPITRHNWTRMLGLESSYSSFLLFFLAEIDVRGAVATIERYVFARDANAPGVAMLARLFSGILHPIIHLGHALECGGNDSLAQALAETAVSHADMEALFPSDEVCAMLEQRPRSSVAVEEHRRQIEQGVVPEFDVLASSQLDAREYAGTNAFETLAHLDAAPHLDDCGDIKAGDTVIAGAHSHGAAIAAIARRWRVHIDQGWTDVCLKAEELIWLITAIFGTTSSPNERLKMDFFFCHLQTPLFTYAVVLPLLTPWSRVAFLTMHFRTACCSWVSRGKPALRFGELCLSGERAELRMPPASFKPAAVDYTRIRQGWEREIEEHNLWWKIGQRAAMHLDEHVAKSLRVLMWCGARVGSRRRGVPSLLLPRAECMPNPSALPLFTPRGTLDAHVEPRTEWAPRQRRSIAPQSVAQIDHTLFLRTALLVLEALPIIDADKARRYKDTYKHDWSLLPTGRQAAYRLDVWKLLAGKEATPANPRTDSNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSK9</accession>
    <name>W3VSK9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase family 39 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSK9"/>
    <dbReference type="HOGENOM" id="CLU_023231_0_0_1"/>
    <dbReference type="OrthoDB" id="3445803at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="660" mass="72402" checksum="21963A6864DF2527" modified="2014-03-19" version="1">MMSNKSRSDPPFSEVEHFVLACKLWRRSQLDRHLWQPPCAPTWRHDEVGSDRDRPLLDTLTLSLIDVRLPKAASVLIKRRRILSSSGAAMQASAMTTAFPFTHCHPRRLRDLLKSGAASRMPHTQLSPHELCELQDTFRASLPTCDTDPCVAQRHQIEPLRTYKDPREPTLAFSPLLTTPIRYDCVFATMKYLLSLVALATALNSVQVSHAAAAHASLEKRAADTITVHLDQCRGPPQHYGSGMLYGAQGTNSPPQSYLEKLGINSAPLITDISAGGAQSPTSGWGSSKAHYDARFMTVVDDWKRMQALNGSFVIKTSDLWGADATQGPNFPFPGDGGNWASYDAFVQQIISDIKKHGMDVSLMTQIELWNEPDLGKVFWARSQDQYLEMYARGSRAFRKAFGPKSDHHLPLVGPSSASPNPNNDWFKKWLSFVRANKDVQPDIYNWHLEGGGTNDPVSSSQAMRDLIRQYGLDIGLGFQTNEYGTREQQRPGYAAWHHARYEKVKFHGMRGNWAGGPALRDNLAGLLIKNPDGSYAETGEAHVWAIYGGLKGSPCVTQEGHALDSYGIASPAKRTASALVGNTGFTGTANVVFKGISALGKGASHLQAEVQVIPYNRGAAVAAPVRVATQPVNVEQDTASVQINWTNADDAYLVTITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSM8</accession>
    <name>W3VSM8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02109</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSM8"/>
    <dbReference type="HOGENOM" id="CLU_000688_2_0_1"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="194"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="415" mass="46743" checksum="5B187766DD732A4C" modified="2014-03-19" version="1">MEELGIASLRRTEPTLEDAAAEKAAIHQEMAAEEDTYLRYKKLQQHLEFLNTMEEYVKDEQRNLKRELVRAQEEVKRIQSVPLVIGQFLEPIDQHTGIVGSTTGSNYVVRILSTIDRELLKASSSVALHRHSNALVDVLPPEADSSIAMLGQDEKPTETYADIGGMDIQKQEIREAVELPLVQFDLYRQIGIDPPRGVLLYGPPGTGKTMLVKAVANATTASFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQGSNVKVIMATNRADTLDPALLRPGRLDRKIEFPTPSRREKRLIFQTICGKMNLSPEVDLEDYVGRPDKLSSAEIASICQAAGLQAVRKNRYVIMPEDFEEAWKQIVKKPDDSKMEFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSX2</accession>
    <name>W3VSX2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSX2"/>
    <dbReference type="HOGENOM" id="CLU_027018_1_2_1"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="36"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="355" mass="38309" checksum="7E008C4BDF495E1C" modified="2014-03-19" version="1">MSSEAGPSNTTPSLKRSQLSSVVLDSHSSTSVGSSISLHPLPILNISEHLVRTRLQSNNAETTVYGVLLGTQQGREIDIQNSFEITLDATASADSPPIVNHAFLKARQSQYKQVFPTLDLLGWYTVGEVPTPRDLEIHKQLLAYNETPLLVQLSQTVASFENAEATGALPIRVYESVVEVVQGETASFFVPAGYKIETGEAERIAVDHASKAGAESGQDQESTMLASMQAQHSAIGKLNDRIVQVLSYLRAIQDGQAAWDHEALRQIQTVVANLPNTVLPELQDEILRDHNDVLLTNYLSVLTESLHTMNELTDKFELVQAGAKPDSDAVAGASASVPQGRRGGGGRSSALRAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT52</accession>
    <name>W3VT52_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT52"/>
    <dbReference type="HOGENOM" id="CLU_088983_0_0_1"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="209" mass="22845" checksum="3D179A5A6276EBB2" modified="2014-03-19" version="1">MAAAKEFKVVLAGQFGSGKTTFATRIKSAKSDKKEIKALKTTQYPVTLQTSAGQVTLNLFDTNLHAKGGLPDDGFFRTADASIVFFDLTNEGSYTAMEDWYDAVIKANGRKGSEPLPVVVVGTKADDIKGRDIKPAAIEFPRKKEHTYREISAQANYGVKELLLDVCKALLGDSVQLTAEVEMEKPSISKIDEEQLEKLFAEYEKAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT84</accession>
    <name>W3VT84_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT84"/>
    <dbReference type="HOGENOM" id="CLU_337755_0_0_1"/>
    <dbReference type="OrthoDB" id="5964929at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="822" mass="86706" checksum="E1B7386FE019335D" modified="2014-03-19" version="1">MATNMLLSPEALHCLKRKQLTNLCRRFGIKAVGKNADLIQRLQEYAASNIPSDSPTKGNVAVLRHIKRPRQSDASSDSDSDNQHREHKPTVVYPPLTPRTRQKRVSDIVQAIEEVKAQPDEMDSDDELDEAEVKSPSCRNTIAFPVKQEQAPLSPQSTQPLRIIKALPSSTRLASPLSTATILELSRTPAAHEASDAATASMYPDISTLPLPEGVSSDCLASSSTLPSITSRQFSAAAASVLAEMNARLTAAGRFTTSASLSTMSSMGNGAWQTLASSTSTQDMSKSRSGRYEIQHERQFKKMDSIVNHYAARRVGASDKSDATSSTCSSSDTSSSAAAVTKSLAVARKPQRVDASTSTRSLAAMVHSTSTRKLVSQRRPLPVPPVPKARSNPPAAAAIRSANPPSSRQASGSEAPRTKRLRLAVTEDQGALQNTVLEIPPEKKTVMIRVTRPEREGMPYQVSVAPSTSEAKKLGEASGPVRAASVLRKSVIKATKSTFTGGSAKKATASAQAQKREAAFAKQQQHAAAMSRSMSSRANLAPTVSRSETLQASTSVRNKFTGALTAPPTVTRTPVAAALAGSGASVVPSEASKGSVSRLGGSIRSSVSQGLGRADAARQARLKEIKARTKAALAGFGSTRTVDAAAPESPRKGATFSPSVTRPTIASLNRAVTTTGGSASLPMLSAITAPLCGLNSNMVEGLQRAATMHAGVAALMPSLTPRSSSLRHLRRVMRKQQKQAEADHERVAAAENISPGKVVPSVIKPPTSELQYAPSIRTVAKVQPSPDKYTTLPLQGRTAARPAGARSALVTSRATTSALNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTA4</accession>
    <name>W3VTA4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTA4"/>
    <dbReference type="HOGENOM" id="CLU_1455005_0_0_1"/>
    <dbReference type="OrthoDB" id="10654698at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="186" mass="19295" checksum="0F009C4E04B2D42B" modified="2014-03-19" version="1">MLSSAWHSPTAFPGSIVGAYNGTKALASPASPRDGVPILRDGIILALSARGHLCIKASLARIIPPAGNSAIRRDEMVPSSANCCPDVRSASASPPRDPTAPPAIRAARSQIVLSIVLPQWFCRLSTISSTVSGSGREEAALSNCPFLPEISSALRLRKSRLALYADVGGGLDVRGLEPPVGHSIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTD9</accession>
    <name>W3VTD9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTD9"/>
    <dbReference type="HOGENOM" id="CLU_540979_0_0_1"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834863" description="Peptidase A1 domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="140"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="511" mass="55176" checksum="D436E42E0308421B" modified="2014-03-19" version="1">MKSNTAWAGLAATATLTALVSAKHELDVSHEPITSLFKADGTPSHPHFLQSRWVTSELPLDYRKRDLSGTGSKRSSKTCRADKSKPRAEDRKHHGRHSVLNTLDHLGHQVASWIEGGKYHDHSLGIVINKATDNSADNEWLVNVGFGSPAQSLKMVFDSGSSDTWVYSPQCCYANNHTFFDPTQSDTFHNRTLVNNLAVPAPDGTPGQAWSSTYGSGSSVSGYVGIDDFTFGQQRLTVDQLPIALVTSIKGSRAGRGMEGLVGLSAGSGSETPGEWTTPFEAMSSRGQINQTYLTATLRKANRNTGKGGGGRYVFGEIDDRLLDGDITWTRALSPYLWAGYFDKMTFGDSLLAAAPGTQDRPIRFMIDTGSAVFYLPPPIVKQINSQIAGSVVANSSSGLAFPYLVPCDTGLKRHERTAKNPSFNLQVGGTNFTIPKEDYVFYANQPVPAAAAGGKTGMCYSAFQTGPAQISIIGLSFIKNHVVVLDQGGRNLTVSARRIGLGQRKDVRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTF3</accession>
    <name>W3VTF3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PaG_00700</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTF3"/>
    <dbReference type="HOGENOM" id="CLU_035539_1_0_1"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833281" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="178"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ETS64745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="500" mass="52993" checksum="4A85C2384E10EF63" modified="2014-03-19" version="1">MKLSSTAIVAAVSLASSVTASIGRGVPDPHHIQNLYRRARDSGEYHNLIYKRGSPAQAALKARATDEPSQAAITNAKQECTAYNLPEISALASQFPTPWENATILPGDSQAQAVWSSIQASGIIPAGITPKGTVNGDFSSFTPTYPHSDPDCWWTFNGCDNPKHPNIPADLVQCPEPNTWGLTFDDGPNCTHNAFYDFLQKNKQKATMFYIGSNVLDWPLEAQRGIVDGHHICVHTWSHQYMTAFPSDQVFAELYYTAKVIKDVVGVTPTCWRPPFGDVDDRVRAIAKGLGLETVLWTDDTDDWKILPLGTLPTASIDANYASIIAKETQGPTAGQGNIVLTHEINGHTMDEFMKQYANIQAVFKHIVPLTACKNQTKPYPEDITYPDFAQYVAGNINATGLPSGSSIKAADNHYNPQLAVSATASGSSAAASATGSSSGSSSGSTAGSGSGSSSSSSSNTGTKQSQQSSKSDASSLQSSLVVVGSLAAAGVLSAVVMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU24</accession>
    <name>W3VU24_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU24"/>
    <dbReference type="HOGENOM" id="CLU_015935_3_0_1"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="435"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="579" mass="60987" checksum="F72D881FD5027DA9" modified="2014-03-19" version="1">MASSSRPSSPTSNGHTNGTSSHSNGADASSSSTAHAAAAAAPAEPSEQDKQQAQQLKTEGNSHFSSKQYSKAIDAFTRAYELDPTDSTFLTNRAAAKMSLKMYKSALADCQLAKDVQAKQSADGVAQPKTLVRLARCHLYLGNPSGALSVLKPVVSMEGIDEATLKQASQLQKQANSVADHLASYHSLSAQNDWSVAGFALDQAQQYAGLAEADVPLAWRIMRATVHLHKNQLDNANSVIADALRADSSDPEALLVRARILLAKGDTAKAVAHCQAALRSDPEQSGARDLLKKCRRLEAKKEEGNTAFKAGDHAAAVARFSEALELADENAARDGPAQGFKAILYSNRATANSKAGEHDAAVADCDAALELDSGYVKALRTRARALLATEKYEEAVRDFKKALEEASVGGGREAEQLQRELRSAEIDLKRSKKKDYYKILSVAKDASDSEIKKAYRKESLKHHPDKGGDEEKFKLCAEAYDVLSDENKRRRYDAGADDLEHDGMGFPGGGMGGFGGPGGVEINLADLFGAGGGMGGMGGMGGMGGGGFHGMGGMGGMGGGGFPGGSRRGARPPPGFHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU84</accession>
    <name>W3VU84_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho3 gtp binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU84"/>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="134" mass="14824" checksum="CA4798CA8EE27F61" modified="2014-03-19" version="1">MTLWDTAGQEEFDKLRTLSYADTHVVVLCFAADNPVSLENVETRWVPEIRDHCPGVKIILVALKCDLRSGGEGEKRRMLSYQDGVRVAKRIHASRYLECSAKLNRGVNQASLEIASVAAHAHPNRSTTSSCTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU90</accession>
    <name>W3VU90_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin-containing amine oxidasedehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU90"/>
    <dbReference type="HOGENOM" id="CLU_019746_0_0_1"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="66055" checksum="86EEED5E53220493" modified="2014-03-19" version="1">MSSSSAANGQANGGAHTKPKKRVIVVGAGASGMSACHAFSLSPDEFEVTLYDKQCSLGGSATSYQLPDPAKYRSQYINDGVQGASPVFYNTFKVFEHVLGFKAQEVGMQISFGKGKDTFWSNVFPSELVEKYAADIKKFGTTLKTIKRFEVVFAVIPVHRMLKMFGFSDEFGERMVYPLVALFFGTGNDTKHISSAILERVFLDPSMRLFEFSEDSLLASVPTMMAFPELARVYAAWHDEVTKNGNVRLEASREVTQIERNTKEARKRGGNIVVTSRRVDKDGKPLATGDDEERVEVFDELILACDADTSLKILGKAATWKERKILGSIVYRWDITTTHNDYDYMDKHYQMTYDAKYNAKHRDDEETKKSFKFAEENWKPLYLIKMYDDDPALIEMSFDLTNYQPQFSGSGPTGPRDRGARSPDSAPPRERQGPHGRQGDSQEKELSQLPSTNPDDLKDPPVRDHVFQTIFLNKDLEDKWTRNEIGKDKVILEKWWKQQSHRWTHYAYVVPWLWLINGANHTNYCGGWTLVNMQEVAIVSGYAAAVAIGAKYPFEQDKDCARLFNLYNALAHLSFKNAKKALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUC7</accession>
    <name>W3VUC7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUC7"/>
    <dbReference type="HOGENOM" id="CLU_053720_0_0_1"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="334" mass="35683" checksum="2CA6758C1E048B81" modified="2014-03-19" version="1">MLDFTTIEPQRYIPLMGLGPLGSQLQGVLSNGPFKASASLLSSGSANASAPAKPESGLATPTLSGSSTSDSTQELLDLENGPSRYAAYAMRLKTVIVASSRYVAYSSDIGEAFRPLTSPAFVRGAYAVSWTYILGDVVYAGYKAAQQYEALASTTFSKSGPVQELESEAAKLADKALTSARENLPLEKLLDAKTLNALSPTEKVELRKRHVERLAEQGDHAGVDPNQVSEATHVGLVMARRAVFQSIASMALPAFTIHSIVRYSAPVFAKAKSQRIRAAGPTVAGLMFVPALPFLFDEPVEHVIDFAFDWIQERLLGGPAAAHKVVEAAKEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUI0</accession>
    <name>W3VUI0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUI0"/>
    <dbReference type="HOGENOM" id="CLU_000445_69_2_1"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="80"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="268" mass="28062" checksum="70C17F55AF0335AD" modified="2014-03-19" version="1">MAAVIMSQHTAAPSASAGYPAYLGSSSSSSSSSSESSCCYASSSSSPSSTPPPLASAPAAALQAATMAYTHPPEESLPFVVLVVDDNAINRKVLTIPLRKQGIQVVEAENGLEAVQMYAQVRPALVLMDISMPVMDGFEATRQIRMHEQAQSATMPDIDGEGAGVDEVVNMLLTHQRARIVAATTHSADRDFAEGKDAGMDDWLLKPIRPSTLVKDILEFRRNHLQDFAATLAALATAPVSMAAGETAMEMVLDQASTPTATAAALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUL6</accession>
    <name>W3VUL6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUL6"/>
    <dbReference type="HOGENOM" id="CLU_031477_5_0_1"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="47263" checksum="BC0B58189A94B88D" modified="2014-03-19" version="1">MSSRPSAKVLSESPRSSPTPIGPSSPTSAHNGSAPPPATRKSITRQRSSSLQKGAAVLRALSRAESDFDREMLERSGILQSDAPASLATPVQGAATAIDTSASSSTADMTANGANIRRRAQSSKANTSKSTSSKPRSNGPVAPASSKSWEIPRKIFHSSIGFMVLHLYLSGTDLNVIVRNLSYFLGIVVTADVIRLNNDDFEKIYEKVLGFLMRESEKDKVNGVVWYLVGVITSLHFFPEDIACVSIMILSWCDTCASTFGRAFGRYTPALPSPPFARRKSTAGFVAAIISGALTSYLFWCTSIASSGVRTNGISWSGSGYAHPAIFGTDRVAGATGTGWEGLSTGFRGQSGAGLLPGASGLSAQYLGADSIAKGKLGTDALPIHNDVPGMPWWLLTLGSGIVAGVAEGLELGGVDDNLSLPILSAAGIWSFLWSWGRIAPVWQRWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUV1</accession>
    <name>W3VUV1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUV1"/>
    <dbReference type="HOGENOM" id="CLU_729927_0_0_1"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="168"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="391" mass="42842" checksum="38D6CDC45DF6A01F" modified="2014-03-19" version="1">MTAVHAGAELQVGMKTSAAEHGINALRNEAVASTHSPSPSLTSRINTRIQEAGSSRLNETRGGKGSNPIDATTCALQVPANWPSDVVFITQNLVAASVPDSIAEPYVLRPATASLRADEESESSEAVLTRSLPQATHNNGRAQTLYVDSIQDEVPVIIHPIDKTTPWCPESFHSTSRRLSFHPAAGSHGLFAGQDIEADTFVRAYLGVLHTKRDADFYSTYDLSLCHDDRLLDKSPDSDAAALADAVEAVKLDDEDENPTALYVDSRYWGNESRFINDYRGIADRPNVEFRSFIQLDTGDGQAKFQMGLFTTRPLRKGQELVVNYGKSYWLHHDQLALQQAQPAAPQPVKQAPKATVDPIQAMLNRSRMRVSRTAAHPHRPHHPPTPGSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUV7</accession>
    <name>W3VUV7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_245020_0_0_1"/>
    <dbReference type="OrthoDB" id="2556353at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1555"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1583" mass="168921" checksum="106A34D076F86C93" modified="2014-03-19" version="1">MGATAVSRGNLARVTGGAVDSRDPFGADCPTFGAPAEKQEPRVDGSRYGVRRHHSGATVQYHPPPSQSFWRDETSAALELRNEGVDSPLFWKMFREGMERDDAGTLGSGFERVLRPGTRETRPRFELLAMRCIRSGATATAVVASVVGTPQCKLAHHTKPIGFHPLKRASRDERRDGLKDQGARRFSGQKDARPERTRRGTQASRCTASRAGFQSWSSSANPCARSAVLASSALELGSWRQKRCHCSQKLDCSSAPLFAHWTLSELQLVDKVAFALPRLAPLGSPWPMPMPMPMPRAFATASGAQFAHATLVARSPWRLLSSPSSLAAPQWHTLRRIFRSRRVSFLLLSPCFGSFGIVLATPPRPLSLLARPPRPPRLPTLDPFSLDRPRISFCARSASPAQFSPTIMASHRVDADASIHPFAVRTPTLAANSQPHAASSQPLAQARTKAQLSPAYIATIRRRRTRTLDLDSHPSIRPRSSSVSRRSSRASTVSFAPTIASTSASYLDISRLAPLGSLTLSRSMPLVAVESSPQTTPRADAGPSRFPLSASQPTGSKMSTKSHTKRGSMVGALSVADRAKAFQSVLASSSSSANTVQRNARKAAVSSGSASTSASASDITSPSTSAASLADDSEELVATIATARRISVATPVHRRARSDVSVLDPYLAQDLAATASAKPAHELVNPPTIRTSSFAELDELTAKLEANRPRSQTLAHPVRANRANAHLMHSIAEESMHLRLCSSTETIRANKLASSRRISRSGARTPIANAHVTFQVSPCLSDDGSIDWHCFISTNYGVPRTIDDFRQPISISDLAVPIHAGRKREYHSKLSKPDSPTLNDEATWLEEELARCSSDEDDDDDEYDVDGSHRPSVDEEFSTPDGSPLLSPMDLTAPGPVEIMGLGIQDASLLLPGAPEHQPNKSSDSLLEQVAMHEACIRTLHTISQHDTRDHQLSQGLPPMPDRRSSLLVPCAQATTLRGVPSVGDFSSTQAGAAALFGDDTYDASMSPMADMGHGALSDEPRSTSPYPRRASAASYLSTASTASADVSTASHASSLLFNAHLAAPGMARGGSADTGFSTRRSSVASSYTHDKAPNKPPRSPLRLNATPLPPLPQEACETPQPSQYAEAPQPRSPTRMSAMPLPPLPASAPSEEGDKPRSSKESARVLRQANRRKEGTNLPQPPARHGSLEAMVAAAPKETQMREEFPERLLGDWMSARDDTATAEAVEASADERAFRVEPVPLHKRILKKDGTTVLPGLGEIVPPSPEVTAAALMSARDVPAYPGAAQKRLGVETLPLAGAAAQLAKPAMTLKGKLSGRRLGRASTEEGPASMERKTSESSLPNVLGRMRKASSRSESDRSRVSSSAASAAAELPAAWKDRIVGTRPSMDMRRPSFASLVLSTPSSEAGAACASPRGKVATLLPGARDEMRSRSSLGLRKMLSSITGTDGASSSEANPSGGAAESAGRVSLTLEALAATTFESPKSARVAGGRRGAQHKYESFIELSDDETSSSVSASVSGATCESWESDMLSRKRSARKDLTKMFGASEVDLAQGMRGGEADADKWTASVGRSGTKKRSVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUX4</accession>
    <name>W3VUX4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUX4"/>
    <dbReference type="HOGENOM" id="CLU_114238_0_0_1"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF27">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833313" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="19613" checksum="AAE9D876F93609B6" modified="2014-03-19" version="1">MVRTTLILSALLAGAVSAALVPQHETLAPGRETHIGTPVQHISPDMVPLSHPRIPVAPQAIPHNAVDDSSALEAPALETRKHHSKGKKVNGGKVTYYYGSQLLNPACPGAPTPSDSSMTAAISFDSPFQCGDRIKISDPQGKHAVVTVVDRCAGCTWNWIDVTKGVFQVFSGLDAGVLTGLTMTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV53</accession>
    <name>W3VV53_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV53"/>
    <dbReference type="HOGENOM" id="CLU_031804_1_0_1"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150133" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="33"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="321"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="402"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS65375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="561" mass="60433" checksum="CB06CBF07AA157C1" modified="2014-03-19" version="1">MALVKHAARRASAFCSLVVLAALALFCALTSALPSASGNRVLVVVEPSSRRLYSTFFQGLTSRGYQVAFKAPRDAKPQLVEHDVVSFDHLVLLSPAAKSLAADLSPQQLVEYLKSGGNMLVALDSSASEMHRDLAREFSLEFDERATALVDHFRASPQLDAGNHTTVLVGGKSSAAGLSTGGPVPNTNVFAEETLLAAQTKPLLYRGIVHRVGANPLAFPLVVPPATSYSSEASALVKEQDAVVESTSYSTPAPVTVTTTRIIDGETVSSEVVSTPRAVPTVVKSKSASKLGKNGWVANRAGVEPLETKRELVAGVSTGAASIVSLVSGFQLASNSARAVFVGSTDLLSDAFAGSETVNREVAHDLTAWTFQERGVLKVVGTHHHRVRSDASDVREDYEETAAGNSMYRIKDHVYYSLDVVQHVPDRGWVPADKTLDIQVAFRMLDPYITAHLVAEDAANYTHAVEGDTSGAFTRFATTFQVPDRHGVFTLHVNFKRAGLSFVETKDTAPVRPFNHDEYPRFLSSSWPYITGALSTSLGFVVFTALWLTLRQDPPVHKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVF7</accession>
    <name>W3VVF7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVF7"/>
    <dbReference type="HOGENOM" id="CLU_062280_0_0_1"/>
    <dbReference type="OrthoDB" id="63581at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32803" checksum="BB1E66B2AD478F0B" modified="2014-03-19" version="1">MPRLETSSGWSRLTADIKAVFAPSTGSMGERGAILKSVLLRSVRITVSSSGQAPVLPLRIRPAFVVLNVLDLIFLGILGFHPRGQTWIRLNDKLLHFVCFFLATAMFYMIWDVDEPARTSYLWRNASLILSAITCLLVGGIGSEIVQSLLPYKQFQIGDIVANLLGSSLGLWFSYHLEKRYRARRELERLYAPLDIEDYGDLLDDEDDGAVLDPTPNPRSSLKTSSSTAGANKKTRFAADVWDDSLDIDNLPARGPARAAPEATPAVSGSASRQDIFTIDDNEPPSPPSQPNVWTQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVV4</accession>
    <name>W3VVV4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVV4"/>
    <dbReference type="HOGENOM" id="CLU_009600_14_3_1"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834600" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="603" mass="64613" checksum="BBB0C4F3D63D1949" modified="2014-03-19" version="1">MAKLTSSSFVVMLLATLLAYLQGARTSNSDEIILTRSQNDEFYADSAATSRVVNRNTGFPDLLNAGIDDLQGGLSRGEFTSVELVEAYLGRIDEVNINGPGLRAVLETSPAALREAKRLDEERAQGKSRGPLHGVPILVKDNVATDAELGMNTTAGSYTLLNSIVPGDSPSIHTLRKAGAIILGKANMSVWAQARGLVNQTQGFSPRGGFGTSAYWPAGNPCSSSSGSAVAVAAGLATASVGSQTSGSIICPASYNNIVGIKPTIGLISRNGVIPISFTQDSAGPFARTVKDVAHLLTAMAYRGSDPGDNATWTQPPEVAKGIDYAAASHFHTKKQKPLAGMRLGYSGEQFFANQSIQSYDDSVAAAYTRSIQVLRDQGAEMVEVTLECIGDQTDPNQTACYNATDISQTALWQTEMRYGLEHYIAGLKEVPSAVYDLGGIVYFGIANPELELPGNQTDQGYLTQALMTRPNATVDAYREYGFRLSREMGIDGALNKYGVQAIVSPSGGDWPLYPIADRAQYPVISVPMGFYSNTTEPGTDFPYYPYPDAPTGLSFTSRKWTEPLLLQIAHAYEQATHVRWSRRPYSAAEAKSQIKAIVPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD50</accession>
    <name>W3VD50_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GS catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD50"/>
    <dbReference type="HOGENOM" id="CLU_017290_0_1_1"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="7">
        <location>
            <begin position="123"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="482" mass="53500" checksum="A82DE2A6DC5C73DA" modified="2014-03-19" version="1">MSEKQRSITYTDLEELLRNDNKVKLGGVDVDGIVRGKYVSKSKFLSAAKPDSDFGFCSVIFGWDMHDQVYSKELLVSNKANGYRDLSARIDLDSYRRIPWEDNLPFFLIRFFNPDGSPLAVCPRSLLRSVTQTAQRDLGLVCMAGAEFEYFQFAETAQSLEAKGFVNLTALTPGNHGYSMLRTTLNKDYFLELFDAAQAFGIDIEGHHTETGPGVYETALAYTEVTRMADMAVLYKLLAKSVGIKHGIMPTFMAKPWANLAGCSGHIHVSLRDPTTGKNVFGLSADEIAAGGRKDAPYDDVRYLSVVGEQFLAGIMTGLPDIMPLLCPTVNSYKRLTTGEAYWAPNICSYGYDSRLVSVRILGPPDAPDYATRFEVRVPGADLNAQYAFAAVFALGMYGIQHKLALPFAPLDTTRSLKDQHLVYLPTSLEAATAKFMAKDSLARKVLGDTLVDHFGGTRLHEVQLFNQTVTNWEMQRYMELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDP0</accession>
    <name>W3VDP0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDP0"/>
    <dbReference type="HOGENOM" id="CLU_029363_0_0_1"/>
    <dbReference type="OrthoDB" id="2556200at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="651" mass="68049" checksum="2175C9EB32B402B6" modified="2014-03-19" version="1">MSDVSSRPRIASHRIAPKSTHRIAAGGAVETRSHSLGPQPPWLIATALQDPSLIPTSCPPPSVHPCIRAGSLPPAPLLYVILAGPIARSLALSLSRSLARRYPATLLQATLSLPSRRAPPDPTSHPHRPRTPVARTRRKSDPLSRAFRSHLRQPTMYGRSGQQQYRGGLSSWDTMQPQSGYTSSPSQPPQPPQQQQQQPQQQQPGYFGSSMLSSGSRDDVGGYGGYASGGSSSHFPSGYPGQQPGNAASSSSANSRPNTFASFSEAFTGGYNGNSLMPQQQQQQQQQQGQQQQGQQGQQQPNQPSNASYRGEHYYPPSEYGAARDRAAQPMYAQQPGDGFSQPSNGSARESRFDGAYSSANAQQDWSSYSASSNVPMQQREGVQPSQASRSQSAAAPTAQNAPPSASPSVAAAASQPAAAEATVPKKRGRKPKNATQPAAAPAPTKPQGYAQQAGFVDPSAMMIKAAANGTAKGKKAQAAAAAAAAAAQAAAAAAAAPPSAPAAAVGIRPKGKRGRKSKAELAAEAAAAASAPAAPPAVVDISMEAPPAKRKRRTKLEMQAARAAEAEAAARQAALQAAGQVPIPTKDPRGRKPGSKGSYTQAWNKEMVAKVQGLRVFGSMIEDDKTQKDFDRVVIEVLGMLDGKLPGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDY2</accession>
    <name>W3VDY2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="6" type="ORF">PaG_06148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDY2"/>
    <dbReference type="HOGENOM" id="CLU_066058_0_0_1"/>
    <dbReference type="OrthoDB" id="3358442at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="293" mass="31347" checksum="42C519311536E38F" modified="2014-03-19" version="1">MSSSAAVASAHDPALDLLPSELQDTIMEQKFAQIREQRREAHHVLREAKQRTRNQQTDQQILMLMQTDERLASLLSQAADSMRALLPVKPPSPDTVRLAPSDATSASASSSSASEPTHGAKAFEVKAQQWFSILNEVQYSLRSAVRYLRDSNLAPLTPPAGAEARLSGNAGSAARAHNLSLLDAFVDLAGIDGPTFKLPPVAPASTSSGSASPLSEPVLSVHALRKRDRNWKALSSSLQHMHNQSNLATAPSPAHTAPRASPSIELSLLESIRNGCSSDRILIDALVNTNSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEU4</accession>
    <name>W3VEU4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEU4"/>
    <dbReference type="HOGENOM" id="CLU_063514_1_2_1"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="49"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="303" mass="31672" checksum="C88A373ECE554728" modified="2014-03-19" version="1">MSRYDRRRVNGPPSYVPVYDNNASTSNASSSTSTLTTSTQRPDGRAYTQLRSIFLQTNLVPSASGSSYVEIGDLKLACSVFGPRQVKGRQYSGKAELNVEVKFAPFSSRRRRQPGKTTESAHLSGLLHQALLPSLRLDLLPKASLDIHIMVLQTDGLEESCIAAACMAASTALASAGIEMCGLVVGTVALVPAQSSGEQRVLLDPSSADIGLVTGMKTSTRVLLCGMPALASVTCLNVSAGSTQLSSAKKDPGSNAVLTAGLDGNTLDHALEAANAGLVDIHKVVAHALANDFQRRTAVSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEZ1</accession>
    <name>W3VEZ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_06097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEZ1"/>
    <dbReference type="HOGENOM" id="CLU_398545_0_0_1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="691" mass="74396" checksum="B4AE0AB702DD6FF9" modified="2014-03-19" version="1">MATSNANANSTAGGVKGGISASPFDSSRGRFSGTTASLDSTTADKRHRARANEQADESVRGSLSPKCVLFSRALLAGCGLAGFGTGSDFLGRAQPKRPPTMVAVCRHWTCCRSAVAPAVALARSAASGLSSAYCPLALYASTSAWMQLRATHLSQRDHSRIDGRLSPSTAVPPDAMLPLSSGFRCRSAASAANFACHFTPTRAPVVGNRRRIRVVPTCHQPSRRQKQLQIEQHPCCHQPLTLRAIWARTLSPPLTIPSAVVPFQAHLSVSTSSFPFLGRFSPGTSHTLAIMDILELVHEDQRKESRPFDCQHPGCPKAFSRRSDLARHARIHSQERPFSCHFRSCGKTFIQRSALTVHIRVHTGERPHVCESCSKAFSDSSSLARHRRIHTGRRPYNCLVPGCGKSFCRKTTLTKHTRRNHADAEGTYMGTGRTASILSNSFSVARSALPPHARSTFPQGLEHHYLAGVKLEGDGARGGHAYGYAMPHGEYATTSYSAPPMSSCASSNTSSDGFDLTRRSSLVMSNCMTGSSMASFCSPEGTMARVCSTPNTLTPASEMSHFPRTPDHRDSHAFDAHMSARPHFEHVSVANMAYGEPHGPSSFGSSMMPAPASFSVLSNGCVITSQSNGNIDPGLWEGECAPASSMGSHFYANESTMQLQQMQSFQPHHAARSAPYMLRSATQPNPIPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF41</accession>
    <name>W3VF41_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF41"/>
    <dbReference type="HOGENOM" id="CLU_010412_4_1_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000469">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="136" mass="15021" checksum="1C41ACC5B85E7AAC" modified="2014-03-19" version="1">MQIFVKTLTGKTITLEVESSDTIDNRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRCQNGAGTESQCKDAAINLVGECPHCSLKFCGKHRLPEQHKCAQVEQVRNAAFAANKAKLESERTQATRGLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF45</accession>
    <name>W3VF45_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF45"/>
    <dbReference type="HOGENOM" id="CLU_417446_0_0_1"/>
    <dbReference type="OrthoDB" id="2545339at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="657" mass="73306" checksum="070DCD8910D8C2C6" modified="2014-03-19" version="1">MSKRGDEEARQPLLSNTDHDSHDPAQGRPEVSSGSPELTNKDEDRHWLEELVFKTRRRFFVSVCILLGSLYAVTAILTGRPPWAGSHLPWTRTPEPYRSYELGEATRRLEQQPFCLPPANRLGLADTQFVHDRSRDPNWLPWNRRTGALFDSLGHEFDQLAGSKVRGSSQRYRESLHLSMSLSQGEPFYTRNVKAEANSRLLGPTVHHADNRTFRSLALGKAIRRLSVLASSAVDRHVGPEELVQALRLRHSRIVTETKLSPASAPHREAILLETTFSDMHQFAQSIVALYHGESSAADSSLLSPHVIRNYLRRLEPTTDGTTSVTRSAFVAIRKSVVRQGGSALKGVGRHSAGGLRLQNRDRMLEIDVLTELRDEHELVITLDLERGLIVTSLAHLRESRGSKTQASHGQHQVHFGEASLWDWMNASADNIFHGLDWQSDDRMITTLSGTYRYQRQDSSATQPDSGLGGVDWLEVDVTLDERSLWITRIELAPTKAGSPTVSVLRKYNVGGTADFFGGWTCTTDYSKNDLADCYRPHMGEDDSKCVCTDSAAGTTSNYRVGLWPTSSVSRSGSYEIPRAAIRIDGSSYMDQGVGGCPSLWTPDAGQSVPEMHLLGYKLSFTEAQYDDKGKMLRQAGVKWLDVGIDMVRISNDQPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFA9</accession>
    <name>W3VFA9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_05518</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFA9"/>
    <dbReference type="HOGENOM" id="CLU_013783_3_0_1"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="351"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="649"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="712"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS60323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="732" mass="79162" checksum="5E1268BD1FEA2340" modified="2014-03-19" version="1">MLRLLHPPPPPPPLLHCNRRSPRPPRLTKWAVQASAQSLPLADSSSTAVHAWAMTHPIHGANAKQPFEALPDVLHTCRSAAPLHPRQPTSFRPLPSSLLHRGCLQQHLDSLRATASTMKLITVKALVAFTSLALMADAAAVRRDPASTLVVKEQVPVPDTWVRRSDADDHQTVALRFALRQTDVAGLEKRLQQTSDPSHELYGRHLSADEVSSYLQPHKRTVDEVELWLREAGVEIDETLARRSASMDTFTVNVPVWKARELLNADLGVYQHRRTGTLAVRSPKYSVPEHVADHLDYVGPLTLFTEPRTHSNDVANIKVLIEDEDEPDFRSAAAKKGKLDNGQPAVCNTSVVTSECLRTFYKTIDYVPQAANKFKLGISGFLEQFANFADFSGFLQQQRPDAAKSYNFTVQSINGGLNTQSMPGSEANLDVQTMGGFVYPIPFTYYSTGGSPPFVPDLATVNNTNEPYEQELNYLISLSDAQLPKVLSTSYGDDEQTVPRAYAERVCNYIMALGARGVSTIYSSGDNGVGSDGKCVSNGATSPKGTRQFLPAFPASCPYATTVGATQGFAPEVAVGDDIAGFYSGGGFSNYFGIPSYQASVVNKYVQSLGSQYKGLYNKTGRGYPDVAAQGSLYKIRIGGKNYLIGGTSASSPTFASVIGLLNDARIAEGKASLGFLNPLIYSKWIGTPALNDITSGSAAGCNVTGFPAKKGWDAVTGAGTPDFVELRSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFF3</accession>
    <name>W3VFF3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFF3"/>
    <dbReference type="HOGENOM" id="CLU_013253_1_2_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000223">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834431" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="110"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="465" mass="47842" checksum="C9383A865C31FB69" modified="2014-03-19" version="1">MKLSGTALAASGLLVASASSALAAPAASSSSSASTVNAGGAAASKRSAPIHIPIRKRETVKRSGNELLEWANEQKAILQNKYGLPSAGASSKARRAQGTALTNVQYDSTWVATVTGGTPSKDYEVVLDTGSADFWIASEYYQPSSSSTFQNRSTAFNVQYGSGQVAGYEASDTFSLAGTTVQDTRFAVADQVSSGLVSGNMEGIMGMGFQKLAASGEPPLWVAANVDTFSFYLERASLTSNNQEQAGGIFTLGGTNSSLYQGNISYNTLIEELYWMVRLGGIGARGSDVSLDGLTRAAIDTGTTLVGGPNSVVQSFYANIPGSQSQGNGYYSFPCRQTIDATLTFGNQQYTIPDSDFVAGTLDQSGSQCLGAFFGLGSSSQTDLQWIVGDAFLKNVYSVFTTSGSNGAAVGFASLASGLNSGTNSKTVSTSSTGATSAASTTAQRTSMLSLAAVLAVPLIAALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGD0</accession>
    <name>W3VGD0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGD0"/>
    <dbReference type="HOGENOM" id="CLU_050727_0_0_1"/>
    <dbReference type="OrthoDB" id="2527463at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="440" mass="46265" checksum="11BC7BC0DD7DCC34" modified="2014-03-19" version="1">MADEQSGKGKGKAPAREGDASRSNETRTSSGSGDGVSSAALSLASALRSSMASSQLGSLMQSASGGKTEFAQGGSGNADLREWLVSDLRAGANASSAGSTTNVPAKPSFRSTSQGASADGAETEHMFREFERGLALDQSALRAGPTGEDAALQQAWALNTNAGALQAGGWRGTGMDPSTTGSIHSYTELDSPLHASVRKAYAESSTSAGQAQRPSRLGSFPATAAPLAQSDDIFALLDAEEQASSQPNRNIPAMPQDPTSALSSEVLSRFDAAYRAPSPSNSGFSREQAAMHLSLAEAQASEQGRQELAVPRPDNSSAQEGVYAPTAEAALASILDGRPESSDVMETQTHDQERGIAVVRKITRYFGASTYLDDVYGQSPLLRETIEQATQPADDAKSEQNRQKAIRRLESLWSHLTNTPPQPESSRGSDWVDSWLRSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGG3</accession>
    <name>W3VGG3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGG3"/>
    <dbReference type="HOGENOM" id="CLU_048602_1_1_1"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="423" mass="46732" checksum="A553102DF2FC8D21" modified="2014-03-19" version="1">MQKSCAEPGPRIRRSSVGTDSAATAAQRLLRRTGSPQLTPDAASLAMRFTSCSSDSADRINSDECEESQLLGSFERRAHVGLGYVAVVQIDAQRRRHQSPRRCHDGDFRAPVADEAGQDSCTSSALDHSQPTNDQSLMIIAAMWPFSSSSSPTSAAAADTADKCPVDEETRQAWLRANPGKAHPFQPDSPAPKQEHDSQPGPSRPRYNDESRLSTDREISSIPRSYSRLANPTAAQAAQPPSTADEDTDGKWVYPSAKQFYNAMKRKNQNPQVADMDVVVPIHNAVNEQAWRHILAWERMWTAESDTKLISFKGRPRDLTWRAWFNTLAGYQPPFDRHDWTIERPNGEQVRYIIDFYTGKSQPSLSANTGPGNIADSFGAGAQSKAGLSFYLDVRPAPSTIQGMAMRSRRVYNRYFGEPGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGM6</accession>
    <name>W3VGM6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PaG_04617</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004118_1_0_1"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000007">
        <property type="entry name" value="SNARE complex subunit SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Longin" evidence="21">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="22">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="25">
        <location>
            <begin position="943"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="974"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="24">
        <location>
            <begin position="1336"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="496"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="568"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="671"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="727"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="818"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1237"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="19">
        <location>
            <begin position="943"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="922"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1239"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ETS60714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1518" mass="160190" checksum="0BD16610F194B7D1" modified="2014-03-19" version="1">MPLSTQIARVSDGLPLAQSVDDGKTENDLSEHKQQAKLIFRRITPSSEPRCSIESGKFTLHYLISPPPAMPNSVVYLTIADKSYPRKLAFSYLDELSKEFERSYGNQVEQRTLRPYAFVSFDTFMQRTKRLYEDSRTAQSAASSNLDRLNEDLQDVTRIMTKNMEDLLWRGDSLDQMSTMSSSLRDESLKYRKAARQINLDALYRKWAPVGAVEGETRSSPPEPELARIELLPAVRFGPLKRARATGKLQLSEHAKVPKSVAVRQPTNTSSFSWSLHSSSTLCDDLGTANIPQKQPPRLLRKLFDSVDKHSSLQASGPCRSLSGSHLDHSGTCSRQVCVGASASLVKASAESRPSSFKMSVSPLIPGNSIWSTNASSAKQERSAQSILGTSAGANQASLDASAHELSASDRAEVMRAGAHPLPSKPVGPARSNSAVSVKSADEGARSADSAIVNAAAKPGVIGGARTAATTGSLRGAKHVDVSRSNSLAASVQSFRTANSGSPLPMQSRDYANNALHPQPRGLNPLQSPSIQDNGTAHLHDAGRHTGSESEFGTPRLFVDAQHTFDPASASFSRSPSTSSHAGSNLNLGRPRPNSWMHPASHDKSFESNRAFTRDAADAQSSRPASSHGDRRDRLPSQVDDMDPAFVSAVAGKRSVSATYGAGPFNAPNPAANDSLAPASLPSAAGRGSRSDRHAGPGRATPNLVVPNYMNLSGGLLSPTAATIGSAGASGVHSPIGSPLSGSGFPSPSPNRSVSVGNIFDRHSAPTDDALGESPLIKEMLERLTRVESGMKDFSRQISGISRNVSLLLERTKALPPASLGLLGTPQMGAPGGMERATSPRIGANGGGQFGLGPNGSFPQSGALSPRPGGNGRNWNAPNSRNGQDPGPDRRWNQAKPPANYRKEQSGVSTLGVTSAPGLDDGTSTNGTLQTGTGHVQPNAIVSKWEHLNLHPDLLRSILKYGLGPPNKIQQRALPFLLRGSDIIAQAPPTQERIASYVIPSLQLVLNVLNETGGPGQTASNRGPVALIVSTTVDQATQAQRMALGLGAPLGIRVHMVAASSIDVHQEAQSLIQAWPHLVVGTPQKMSELFTYMTSNASALSAHGSGPAASAMRPSEVRLVVLDEVDQLIARNLADHVSTMLRVLPLPSAPAGSAGDARMAGALSPGVPQGPLNGASSPFEQATDNFGGSASAPSTMDRQVALFSNTVPQDVLNFAQSIHLRESVRVLVRRDGAGGAGSSILQAPSSGSNVNAPSNLGSGMQAPGPQRDVSQPSNALGAHPVNSSMSASKDPLLAALKGLRQYYLYVAVTSNGGGMGATSPIPGLTHNPAGEMKLDLISDLLEDIDFGQTVIYCANIAIQEALIYKLSSKGIEALGLNREMNTYTRQQTLAKFRSPSSQFGTHTMIGSATFAQPGGFVGVAAGSRTRKALVVCDLAVNPKDVHQIPLILFYDMPRSVEEYKEKISCAAAGSLARPSVCVNVVTASGGPRGDVEMLRTLECHLGCKMAELPMDSKQILNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHI1</accession>
    <name>W3VHI1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-coumarate-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHI1"/>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="459"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61195" checksum="E2D83A3B52F75B1C" modified="2014-03-19" version="1">MAPQIIKAREADPPRVQRGNLFDFLYSNPNKVDENKAAYIRLDGKKTTRKQLHDDSRRLAYALRHTLGLQPGSRVGIFSPNSTAYPWIVHAGLCAGVVLVPMNAAYGAEELVHPVHDAEIEYIFCHQSVLSTAREGLELAKLGPKSKNGQNRLWILDDGDSLKKGDKGEVDARTLLGDGRLDTHKVVDDRTEDAFVVYSSGTSGKPKGVQLVHGNLTAVTTAIVSTFGDAIGPNDRYVGVLPSFHIFGLAKHMFKSIYIGAECIVVPRFDLDVFCSAVEKFQCNISYVVPPILVLLAKDPRAKKYNLKSLKWVMSGAAPLGTELSLEVEAAHPGLRVTQGWGLSETSPTATFARPDEYHDHMGSCGRLLAGVEGRLVDDDGNDVGFEQGENGKPGEFWVRGPTIMKGYLNNKAATDDCITQDGWFKTGDVAIMKDGFFWIVDRKKELIKYKGFQVPPAELEATLLSHPKIADVAVIGVHDKAQATELPRAYVVLKDEVAQKENPEQVAKEIIEWTASKVANHKKLRGGVRIMEVIPKSPSGKILRRLLRDEAAKEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHL6</accession>
    <name>W3VHL6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04998</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHL6"/>
    <dbReference type="HOGENOM" id="CLU_585414_0_0_1"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="367"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="469" mass="50275" checksum="6FD33A931A810545" modified="2014-03-19" version="1">MPTTRTGRQSSPSKDADSPSKMRVQPMRGARLRSASPFFDASSASTSASASQASQASQAASPSKSARTSPRKKVAATASLQAPTRRSTRSRSRSVDPESLTAIDEDTSAPQTRDVSEAPDSETDVSQSQHIQVESEGDNDDGSSPESRLPAITEEVDLPATNVINADEDDASSKASFDSEDDSASDSDSDSSSSASSDDSSSDSSSGDDDEEDAPAAADLSALLKASQQAYKQRTPAAPAKNRFEDNQDVISFDADAREARDSKRATKNVPLVVRAKQQVSKSQPGPSKKKEDKLDKQIEALEQGAIPAEVKKSKHARTVQTTAGSNWFDMPEFGASSSRLAALKKQSAADSGHAKVTGGDARLASAEQLRREVQALRLRNALDPKRFYRASAKNQAMPKFAQLGKIIASPLEPKAVLSRKEQGRTVVEELIRDAEAASYAKRKFSESQASHRSNYNGRRKPPSKKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHP8</accession>
    <name>W3VHP8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHP8"/>
    <dbReference type="HOGENOM" id="CLU_019106_0_0_1"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="6">
        <location>
            <begin position="689"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="766" mass="84311" checksum="CB667B2DC62552E0" modified="2014-03-19" version="1">MPGRGPSRRRGGNASSSLSRSATFDDIPKDDEDLFEASRDQILLDGQNGSYDSDDDMDVGLSNREVLGIDEAPSDEDEDSDAEDDDEAEDDAEEYDEGLSARQSRGTKKRDIEVSSDDDDDLDMDDEDEDEEDDGPQMHENDRGWGTNKRAYYNTNDLDDMDSDSEIDEKEARELELKEVKRLQKKSRSAMDDSDFGLGGDADVELVKSAKDAGREQRRRELDGIDEEPKPSPTQEQQQQPAAPLSGGTNDENTRRALLAKLQQTSPEAVALAGEYADMLEEFGRVDSLIKKLTVEQPKHASLEIMHVHYQTLATYITTMTFYFHLRTSPEFASEPAKLRTHPVMQRMMRLKQGLSVMEDLGLTLDPHRMPAVGGLTSDEADEMHMLSQGSEDDDLGELDDDELLDLMADAEASGKENAAPRQASKPAKKAKKQAARQAEDGAEAAGKKKSKKADKGEKKAKKTKKAEPVAPLAAGLADLDDEPELLVKLKKKGAKASSAASNPFAVSGDERQFEDATFGELSGLSAIESAERAARKRSLQFHASAIESKALQRSKAAKERQSGDADIPYRDRERSRAGVEATKAAREAKLQQELNGGRGKDVSLDGDDGWGEADEKDWREVMDQPTSSNGAASRGGEDVSDDDDDAAGYYDLVASSRKRARAEKKAEYDEARNAERFALMEDEELEDGQHRGITRQIERNKGLTPHRPKTSRNPRVKKRLKYEQAKKKLGSRQAVFKGGQSSLQGGYGGEASGISTHLVKSRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHR1</accession>
    <name>W3VHR1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_05523</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHR1"/>
    <dbReference type="HOGENOM" id="CLU_2347607_0_0_1"/>
    <dbReference type="OrthoDB" id="44067at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="97" mass="10815" checksum="0CC03130EFDD1239" modified="2014-03-19" version="1">MSLAKSVYNTVFKRNSVYVGSIFFGAFAFGIGYDLATTAWWDAHNKGVSLASPLPHTTAQPTQQPLTHTHPCSSSSIPKRQQKQWKDIRGKFLEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHS8</accession>
    <name>W3VHS8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHS8"/>
    <dbReference type="HOGENOM" id="CLU_096980_0_0_1"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="224" mass="25277" checksum="B48473CD2B2557A6" modified="2014-03-19" version="1">MSTPSTDTLYSQSPHSPIDKREARRKLKAQHRAGQYLDPTYVTCLVLLLALLYWVLPIPGIFELLYRRRHSACSCDHTAAVTQKPTMPWQKQFTLSSRSKGCHLVTNEIMPHIEEGLKGVKVGMLTLFIQHTSAALSLNENFDRDVRTDMDMALDHIVPESLPWKHTDEGPDDSASHTKASLIGPSITLPITDGRLNLGTWQGLYLCEMRRIAHRRKIVATILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHT7</accession>
    <name>W3VHT7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05558</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHT7"/>
    <dbReference type="HOGENOM" id="CLU_012774_1_0_1"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="579"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="958" mass="103589" checksum="BB8F709DC2B8EA15" modified="2014-03-19" version="1">MPPNTTPSFAFEPVEPLPTPDAGSSTNHFRAFTRVPRVLQVPDSEGEGDNDGDDLSSDDDGGDGGDDNQDENHDRRSQVRAAASSKPTLEAEHFRIGDVVYLPSSYQAPLAGVLTHLWTDASEHGKIFGVCRLLHWPEWMSTMAKKRMAGITSRHEIYYTHKATSLTKRRTKTSERSGKEGDTFEAGPSLHDYSFDVDEIIAKVHIHPSHADCAKAIKDSSALSTLSANLDDNAAGTPRKRTSKISTLYKNKSFPTHLFCERAVDPNRELFWRIDWAKLVSKGVQGAGWDLKDDSSDVATSQGQGVKDLVEQAHRDSSAAHPSSLSTTRLRERSSTPSSVASTSDLASASARKTLSASGLDTDAPKRRPGRPRKEDTLSAGVAAPKRKYTRKKAYSSDSDIASDDSFQSGNEFEAEDDLLVKARHLDTPESSDAEGSQFSAPPSEDDDDDGDDDYGKTFNLTPRKRAKMPKDAPMTPTKRRVLSTPQKALYGLASPAKAQATPRSKARLMGIKARSLPHPTLPTRPPKLSLLPDQEALTPHERAKRLLHVGATPDQLPCREDQYEEIMACVEDAVEEGIGGCVYVSGVPGTGKTATVREVIRALTARAERNEMNPFSFVEINGMKLADASQAYTLLWSAISGGQRTSPKTALGLLSSHFARVGAKMSGTGGAGVGAGPGRAATVVLMDELDQLVTARQDVMYNMFNWPNTRGSRLVVIAVANTMDLPERTLNAKVASRLGMTRITFMPYTDRQLVEIVKSRLGIDAGDEASGCADVLSLDAITYVSKRVSNVSGDARRMLDVCRRSIELVEAKSASSSSAVSKVTILDMKSVLDSMVKSGKVSHILSLPLHAKIVLLSVLSCLRRSGLAETELADVAAHHKAICRMFAVNLPATTPGEETSLNSPLATLSSLGLLICVGQGAGTGRAAGYARVMLACQEDEVRLAFEHDPDERLRKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHT8</accession>
    <name>W3VHT8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHT8"/>
    <dbReference type="HOGENOM" id="CLU_052367_4_1_1"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="125"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="310" mass="34150" checksum="D7695A250F96BBDE" modified="2014-03-19" version="1">MRTRPGSIRAAELQAPSLCARSRSAASLEAPSSDPSSFLANTSRSMDRLDQPLSDTPMPRRSGATSRSSPYSRNARSRTADDTGLWKHDRYDENASARGPRRAGSGRPLSFPRDPAETNEVKATGKLFIENLHWDVSEQDLKTLFEQIGPVAKAYIKYDRSDRSTGRAVVVYDNPNHALQAKNEYDGAKAKGQVISITQEMRADRPKVQTHKSLLSRFDLGSRLKGGEEEVAGSFVDRLGPVRHAREGKKTTSTRGENARTAATREKRKPKTAADLDAELDAFMNAPAQESAQTQTQAQPTQQQHDVEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHX1</accession>
    <name>W3VHX1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_05195</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHX1"/>
    <dbReference type="HOGENOM" id="CLU_013175_0_0_1"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="17">
        <location>
            <begin position="4"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="16">
        <location>
            <begin position="439"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="444"/>
            <end position="446"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="444"/>
            <end position="446"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS61233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="768" mass="85078" checksum="5A0DB52EBD5EE32D" modified="2014-03-19" version="1">MATSTVLGYPRIGPQREVKKALEAYWGGKTSQEELLKIAKEQRLQTYKFIKDAGVDVVPTGTFSLYDHVLDASNTFNLIPEQYASSGLDALDTYFAMARGHQKNGVDLPATEMQKWFDSNYHYLVPELSESTEFKINNTKPIDDFLEAKEAGYTARPVLVGPVTLLALGKPGKDAKDAELDPVSLLQKLAPVYGEMLAKLAEAGAEWVQIDEPVLVLDRAQQYAAEFKAAYETIAKAAPSVKIMIATYFNKLESNLEIVKTLPVAGLHVDLDRAPEQLEDVLAAFANTEHVVSLGLVSGRNIWKTDLSAALETAQKAVKALGGNASRVQIASSSSLLHTPITIANEKKLSAEVLDWFSFANEKCAEIATLAAALRDPSSAADALAANAKSIKARRDFEKNSDPAVRERVANIKPEDLARKSPFSVRKEVQKEHLSLPVFPTTTIGSFPQTKEIRQYRARFTKNDITKEEYEKFLEDEIKMVVEKQEALNLDVLVHGEPERNDMVQYFGELLDGFVFTQNAWVQSFGSRYVRPPVVVSDVSRPAPMTVRWSSYAQSLTKKPMKGMLTGPVTILNWSFPRADISKEVQSKQIALALRDEVIDLEKAGVRAVQVDEPAIREGLPLRQKDWAGYLRWAVDSFRLSTSGCSDAMNIASHFCYSDFSLIMKSIIELDADMISIEHSKSGEHLLGAFKKVGYPSHIGPGVFDIHSPRVPSKDEMIGRIKAMAEVLPKDSIWVNPDCGLKTRTWEECTAQLTNMVAAAEECRKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHX9</accession>
    <name>W3VHX9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHX9"/>
    <dbReference type="HOGENOM" id="CLU_035750_1_0_1"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="292" mass="31605" checksum="DC2CD80A8A570D72" modified="2014-03-19" version="1">MSLFGTFPGSSRGPAHAAAPKDHVVGHQFSPYDSNGGSIAAVCGSDFCVIASDTRQSTGYNIQTRYKPKVFRLNDKATLATNGFAADAEALVSRIRQRLEMYRHAHGRSMPLHSIARMISTMLYGKRFFPYYVYNILGGLDEQGKGAVYSFDPVGSYEREFCRAAGAAQSLIQPFFDNQIMFRNQSDTPERKVPTPGQMTLPEVLKIVIDSFTSATERHIEVGDGLEVFVVRTPAAAASAEGDQAQAATGAAAVDLNTLPSDAPFSVAEAVGGEDEQQPGAVMVIRRELKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHY4</accession>
    <name>W3VHY4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHY4"/>
    <dbReference type="HOGENOM" id="CLU_008038_0_0_1"/>
    <dbReference type="OrthoDB" id="2450055at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="659" mass="70075" checksum="A02F60E5B1D01427" modified="2014-03-19" version="1">MPALHHSELEEAQQGQADYLASLAAQVEAQVVAQAHINAKINEDTQTILRAQEMGWRPPSPLAPPNAAFHNLARSTSINSNASRTSATPATSSSTLQQPQPQPAQTGTPSRAHSSATANEPPPAVSASLSPAPLADNDAASVHSVATDRTPRQVEASAERGVARLDRAPTGSTMKSMAAQPETWEAASIAASRSGDAASPPHGHDRTDTSAHEGSVVDKLAVPREDSDAAPSLSASHSAQGSDDGTRIPRTPDDSEALPALHADRAKPTAATAMRPAQRALESYREQSNPTDASRDASSAIGRSDSVYSTSSQQSALGPLAAREANARKLSLWERERERMRQLDNDPASRPSSALYSTSSSHNNGSGWTRSKPSESVTSDRSSGSQIGMGLPRPATGAEDADRYAPAVGSTRLSATGVTRSLSTDTTASERSFVARMKARYQAEKELEREQRQLNVLEKERAARRATMDPTLSLPSLGGARSGAGGGGGRVPEIASRYQMSGTSTYAQEVPARRYHDSLPAGSRLSASSTPSASGVDEFGGLRQTRPEAAHSDVCGCHQCSARHYGSGTTRVERTERPREYNVRRTSMPVPARTGPVDPPRAKQQAIYSSSPARDEYTQYAYRPTQQHAFANAPTRSYDDSPPDAARRVAFARQPQSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI41</accession>
    <name>W3VI41_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000018">
        <property type="protein sequence ID" value="ETS61318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI41"/>
    <dbReference type="HOGENOM" id="CLU_442204_0_0_1"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="407"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="618" mass="69235" checksum="2B428DE061B67B63" modified="2014-03-19" version="1">MRLMLPLEATADCMMSDHAASGQELLTVEYIYRHPTKLLDFLAATLTEQNCLPGFAHDRYYDRWHILLRADDGRVFRITLEAIMQPHVRSDSTTQLLVESMARFPDAWHAEPLDHNTYLACSYMNIKHRCFRSDDGHLLAVRLEVDRLLLEPAKPSHLEKPVAQLAVALLAPHRATAGVEQPSSRELPSAPRPAKSERGAPAKPHPKAKQTSSPEQQSSSESSHSQQSEVRAEPSGSNHGFSGEQQGDAQLDSLSASSTDSPPSTPRQPRRPQNKPAISSDQDSDSPQHSSTPSLQSDAVPASAAHQSFELNPSSSTSQQYDVVHALHENRPSSSKRSFSTFQSCETRQPSSSTEELPNSKRSAPQQQLQAPIRHSNRHFVMEDLHHRVIQSCAYGYQSQHFKVGRRALSPFDMCSLGRKRVVSGDLLDAYFDLVTKHFALDRIKILDSEFVSLLAEMDDEEAALQHGIAKGEPAVGASIADLDLILMPTQMGDHWTSVAIDVKHQQLHHFDSKRTQQSSQMAFKLGRKLLQAEFAVEEVDFGLQVWTERDDERFPQQANTYDGGIFAAQAIRQLCQSHVSLRSLTEQSWNFNQEDIDGLRWHMWLEVTARQIHPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI57</accession>
    <name>W3VI57_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI57"/>
    <dbReference type="HOGENOM" id="CLU_156052_0_0_1"/>
    <dbReference type="OrthoDB" id="2155101at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="131" mass="14377" checksum="761F20583B727F0B" modified="2014-03-19" version="1">MPSYLIGRVVDPMLGLATGVMAYVLWENDGRNAHERPTGRSLPELVRRRYYNEEPPASLYAGPEATTRSLFHIPSASHKTIPTDSASSRSTEQIIADAKDKAARAKGQAGADLRAIRSAVTDEWNQSHSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI90</accession>
    <name>W3VI90_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI90"/>
    <dbReference type="HOGENOM" id="CLU_039562_0_0_1"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834199" evidence="1">
        <location>
            <begin position="22"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="467" mass="52658" checksum="25577256F729CC8A" modified="2014-03-19" version="1">MKLNLLTLLPLAAAAIQTVKAAATPLRRDDWPHGPFHTEGNQIKNANGESVILVGTNWPGSGETMIPEGIEFRSIADIVSMMKYVGYNFVRHTYPIQMVDQIYENNGTDITVQSALLYALGEDNGTRIMEMINKNNPQITNSTTRFEVLSMIAEEEKKQGMLMHLDNHISRAIWCCSHDDGNAWFDDVDFNVENWHRGHSYMANWAKKHSNIVSMSLRNELRKSALRPLDYNWQTWWGNVSAAAENIHATNPDLLITISGLDYDIDLSALTTQANLLDAPYVNTDMDKIANAESMPPQYADIANTKFGKANKAVLELHAYKMSTYYQDHLEDCDAIQTGLYRFGFNALGESARPEACNNSTDFADPYSCPSAKITLPTLLTEFGDAQDSSYANVTMQKCLRDFTTKNKIGWAHWALAGSYRIRQNVVFNNDTWGLTTPTWSGYQSQDTVDNFFRPWIQDMGKTNLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIH5</accession>
    <name>W3VIH5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIH5"/>
    <dbReference type="HOGENOM" id="CLU_019240_4_0_1"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="9">
        <location>
            <begin position="512"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="686" mass="74705" checksum="FC199FC2FEDE820E" modified="2014-03-19" version="1">MAPRCYALVASCSRCRLAAPAHRQLSAAVPAAIVPVQAHDAGAAPGPSSQRRPYTSSSSLPLSAPQRPARPLRPIDGQQRRRFSATALTSAKKKGKSKASSSSAAADDQAAAPSRYPPLPPGWQAVIGVECHVQIKDKHKLFSSAPLPTPSSPLNSLVTPFDAAHPGTFPTLNRSALRLAARTALALNCKVHGESRFDRKHYFYSDLPAGYQITQKYAPLANNGSVRLSFHDGHLPSPEDEVTVEIEQLQLEQDTAKSSYFDTGTTSRLDASRQSPADDSPADDVPEATLHEADDERVQRSFVDLNRAGAGLMEIVSGPQMRTPEQAGAYVRKLQELVRRVGASDGNMQEGSLRCDVNVSVNRVGEPFGTRCEVKNLNSVRFMMNAISHEAHRQVQLLEQPGGCVEQETRGYNESNGTTFRLRGKEDAPDYRYMPDPNLPPVLLSEMQIQELRDRLPELPDAKRARLSKQYGLASRDINVLMRVGSEDDRDGRMVASVGDAEDGQLSSDAVEYFERVAEGRNAQTALNWIIHELMKGLNARNLPFREWYLPANYLGQLIDLVEAGQVTGTTAKAVIADVLSSASTSSTSDISLAELDRLAQTSSTPVFDLLQKQELLALATTQDLLPLVESAFQRLPDEVAQVRKGNLKVAMRIVGQVMKDANGRADAKLVHSTILQQLAQPPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIW4</accession>
    <name>W3VIW4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIW4"/>
    <dbReference type="HOGENOM" id="CLU_002611_0_0_1"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="223"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="538"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="786"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1206" mass="128234" checksum="C60BC4DC45E249A6" modified="2014-03-19" version="1">MAQQGRGVGSHPDEPPPKRRTLQIKLGRPRPPAELDTPEQASPSLNRSRPTSSLGGIRISLKRKAPAFDASHSTPTRFSNLHDSDDDEQDEDVDDGEVDDQPVASADASDQDDGEDEEGDQDDDEDREDGEEDEDEEDEEGDEDAGGADAGSSAAYGRTDANGIGTEAGASGDNAPAPRLRGKNGAFKSTSNGSSSNPFRRPIKRLRSKGLYEAIPKLIENLQRRDSYKFFCEPVNPDEVPGYLDVIKTPMDFGTMQRKVDDRLYSHMDEFKADFQLVISNAQTFNPEGTLYHNEAKRIATWGNRAIEREGMAVNDNGRAGVKGDELRRQKRMAREAASIATGGGIIEVADASGRRVLRGAVQQQNQALQRDASIPPLGDGPVAVGLDTAGGEMTTRLGARGSQFAFSAGVEAIMEAARVTSQARQRAAFALGLTSGTLTREDSAQPGGGAHDGDANMDLDDDDDMDPSDDEGARAGFAGGRDSRERSVTVDGPAGSGSRRFGSSQPGGTPSTPMGQRQASPDALRKRLAAVTGTPIQALASPMGPGTVGGTGKASKQKLKQRLGAPGTPKRLLARTGLTGSATPGAGAESGAEAAGTPGLATDPSAAAAAAAQLMANLPQTQLQPGSGSYSFDDDGSINPDDIEDLHTFLTLHRTGRHVLMPTLESLHPIGFIPGDYTGSGAGDKPKPDSAAKDKEAEKGKEKAKDKADEGDDDDDDGKGESKEKGDKDPLSSLPPARPGAPDPLYSAIAPEPEPLHTNLSHDVEPLPPHFRNLPFLAPSIAPKGAREVGDLPHSWSNPAYVEAVKNDKRPKKQKDKEREREKETLEDWSYFRPTLTRLLEITDLGPFGALVPAMQASDSLKAVSQSKSGTAAKQDDDARDHGLPTTALAQDGLEAIKAELQHKREGFTLPRAVKNRFVEAARTREAKRTGALFTERERQDASRIVADMVYGGVEGSAYVRSVAEFVSGATQHAMLLDEADDAYEQRLAQAEAQLVAAAALRKAREAEPTPEPTAASRRGPFQWRDSTEEAGTSTPAAEEADANLRSAGHTAAATPEKIDDAPAMPNSIEPSEVAVPELAPLSVALAQLVEEEVVRPITRNSLDVLHLVAAYLQTHADAPGVELIEARLARNKLHAHQVEGIDPAALAALAVPPPCASQPMPAPLPFSSELEWLQTQPELTRLLDEAHQDINSLGSIVNYVIQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ58</accession>
    <name>W3VJ58_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04746</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ58"/>
    <dbReference type="HOGENOM" id="CLU_045718_0_0_1"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="292"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="365" mass="38230" checksum="5613066126041B1E" modified="2014-03-19" version="1">MSDPSTSAVGAHQSQVASGPVRPDMVASAISFLTDPKVQTSTMSQRVSFLESKGLRPNEIDEAMRQAGQSQVSGPSGYASYAAGPPTPYYAGAPHPGAYPGSAQAQQQGRDWRDWFIMAVVSGTIGYGVISLSKKYLMPHLQPPNANVLEADLDSLTAKYDEVASQLQALDAQTLAVKQGLDEQKAEVEKSIKEVEDCVKSVRENEKRRDGELDRVRDDVEGIRKELGSLFEKSKQAQTNSLSELQSELKSLKSLLVSRGTVGGPTAGMHAGGAPAPPRPYGVGYGAGSYGSPTIGTPTGDASPPHIPKPSIPAWQLAGAGSSSGTATPSKAPEVEQTKSSDATMADPAEEMSKTEGKAAAEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ59</accession>
    <name>W3VJ59_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ59"/>
    <dbReference type="HOGENOM" id="CLU_032828_4_2_1"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="199"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="415"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="553" mass="59415" checksum="7044D348DBB292E2" modified="2014-03-19" version="1">MVTKFGKARRSFTFTAGQAPAAADAAPGEEVTRGQEKKKSLGIEAAAAILRSHRLYIAVTPAMSFLPSVSSQRSNERSPLLTAQPSSSGLVSEDAIPSRSLTPTYTATASTARSRKLSATNRNSLDHDFVPETARLLDQSLESPSRQHDIADIEQRASEDAEQIPFPSQTDPAKPLRPNNYRREKNVSKLRGFVARNEGILLLALAQLFFSTMNFFFKLINLLPPEESPPVTALEIIFIRMSITWVGCVAFMLASGVENPFLGPKEVRKLLALRGFVGFFGLFGLYYSLQYLSLADATVITFLGPLATGLLGFLVLGEPFTVRETLGGVISLSGVVLIARPAFIFGRKTADSDLDDPLVTLANGTLAGNNSTLKVGEAIAKLVNVTSVDLVRRGNSTLLQDDVSVEGVTEKQRLFAVGLALLGVCGGAGAYITIRAIGRRASATHSVAYFSLYSTIVSAALMWFTDTKFVLPTQPKWIALLVCVGIFGLAAQILLAMGLQREKAGRAVSVTYLQIVYASLYQLVFLHVPIQPLSAIGMAVILVSAGWVAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ66</accession>
    <name>W3VJ66_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ66"/>
    <dbReference type="HOGENOM" id="CLU_047470_1_1_1"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF39">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39676" checksum="987B7DD344B9E93E" modified="2014-03-19" version="1">MTATTVPVIANVAQQIEIDVDTLDVALTQQLKSLGVQPNDMTSNQFIVADALALEPNQLILEQVIRESPDADWLTILDRVSVRLCSLNLPNIAGRALLQASPANAYNAEGIVKHALAYCREFEAVGISKDRFCIKILTTGPGMLAAQILEKQHGISTLGTGLFSVPQALAAAQAGCLYISPYFNEILAHFTPVPERLVYEVPEKQHPMSARMAHIYQAYRELVLAGKCAQPPVIKSASFIAMNEVLAMPALGSQQATILAPTLVEMCSLQTAAAPAGAYKPSKTYSLELPATTLPLLKVDPLREDGKAQTFDLAVDYLANNAAELESAIQQDPETARRIKDAVEVFQKAELQARALIETAMAKVKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJG4</accession>
    <name>W3VJG4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJG4"/>
    <dbReference type="HOGENOM" id="CLU_122036_0_0_1"/>
    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="196" mass="21410" checksum="ECF5D4B1E649C535" modified="2014-03-19" version="1">MVATPSLNMALRRAAATRASLASASASARSLHTTRTVRAGASSSSSSAAAADEEYPSEGFGAPIWRYTFLGAIAAFGLYRISTLHADPHPSRASSSGRSAPGNESEDDLHVEGQKPWLTRYIEHWTTPSSVWKERNARHLELVKEKAEERLLFQDAERPPVHRLRYTQIFEQASPHGIGAGSQVDLSDLKIKRASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJG6</accession>
    <name>W3VJG6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJG6"/>
    <dbReference type="HOGENOM" id="CLU_521945_0_0_1"/>
    <dbReference type="OrthoDB" id="3364069at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="618" mass="67547" checksum="92C0181590DE4DAE" modified="2014-03-19" version="1">MPPHWTRCYHPIHFFTHAHPRSHTPTPRLHQPRASPALHRLVCNPSTITTAASSWNQRLHHIRILRRGAATIFGMAAPIRKGAQRGITGNPGDASDFSSSSVSIGCGDTPPNLRQLRSSYRRFFFLHVLALVPTFAILVAALLGSLKVREFCHLQDSPRDAPHTYASPDSAFQSGYQKGRCRKILDAQLLLSTLALGVVGWLASYTSRKACLAFADRIIPRLFSPSRLLSRSPRFQLPTTENGPGRESVIVTVAIAMQALIGESLRVLSFYWACCILVTALYLYPIQEKYAHRPSTANLIDTAASITGPDWAWRLSFRDPRFFVAAWSSIAWALAEASFGAFQILHQVALYKPADVEPAAEMQWPDSDALQTDRAGVGQSGFSMLSGRGLESAPEPNPTSGRGNGKARRMSASRALEQARQRLVQPAGDLSAPSSYGAMGALDEAVEQVDEEAIATGDETDSQASASSFSSETISLLDQELEEEVERFLVAKERSEVEAVLGVPLPEIPVALCALWRIDAMLWSIGSSLLLSSSFTHAQGTLGHLSHDRFDLSPHFQLLPPFDGFGLTFFVLFVLHTIVSSLWATSLPFLGFATTTYASLLFGLAIMVAALARWGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJI9</accession>
    <name>W3VJI9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJI9"/>
    <dbReference type="HOGENOM" id="CLU_056776_6_0_1"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="110"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="176" mass="19278" checksum="E10AF526A10A96B7" modified="2014-03-19" version="1">MTSHTLARFDSSREMQEDCAFCRIVAGQSPAHVVYEDEENVAFLDILPLRPGHTLVIPKKHVQQLSHLDGATAASLSQALVRTTQAIGRALDDERLQVITNQIYAQLVPHVHFHIVPAAPRASTDAKATPTPSTNALALMRLGHGRDELDDDEAQELCAKIRRAAHEIAQKPAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJL4</accession>
    <name>W3VJL4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maf-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJL4"/>
    <dbReference type="HOGENOM" id="CLU_040416_0_2_1"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26051" checksum="3A230D161CD88704" modified="2014-03-19" version="1">MTTRPDPVTPFALNTPLFNVLAGKRVVLASSSPRRKQILASVGLEPEIVPSTFEEDLPKSEFTGDAVYEYPVQTGSKKALEVYKRLVEENPEDPPDFVISADTVVVKDEVIMEKPADAQDNLRMLADLNGNKCEVVTGVTVIWPVIEAPGFQMRSLCERTVVRFADNPYYLLKAYVDSNEGIDRAGGFAIQGRGSLLVRCIEGDYNNVVGFPLYAFSAFLHDLIENDELDMVQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJL5</accession>
    <name>W3VJL5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJL5"/>
    <dbReference type="HOGENOM" id="CLU_030988_10_2_1"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000004">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="174" mass="19217" checksum="D1831E03082EF666" modified="2014-03-19" version="1">MSTPSKKRLIRDFKRLSTDPPGGISGAPCADNLMIWNAVIFGPADTPFEDGTFKLVMTFDESYPNKPPTVKFLSKMFHPNVYANGELCLDILQNRWSPTYDVAAILTSIQSLLHDPNPNSPANAEAASLYRENMKEYVRRVKATVEASWLDDGENPEPIPEEDEDAPAAQAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKJ3</accession>
    <name>W3VKJ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKJ3"/>
    <dbReference type="HOGENOM" id="CLU_032087_4_2_1"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="126"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="437" mass="46895" checksum="3719B4BDCE07E4AA" modified="2014-03-19" version="1">MSAAPTDANEGAINPTYATSQPEPAQSAPQTSDTMLASSSGPIRTAVRSVATSAAASTSTRPLSGIFGINKPSGPTSMSLLDELKPLFASSPLFADADGKRADDNRKRGKFGKGKGRGKWAGGVAGAPKIGQGGTLDPLADGVLVVGVGSGTKQLQKYLDCTKEYRTTGLLGSATTSYDSQDPILTRKPYDHVVPQTIADLLPRFTGTVLQIPPLYSAVRIDGKRLFEYARANLPLPRPIEPRKVTVHELRLVDWLESGTHGFKEPDREVPDEDKALVGRVLDMAGRKEGQTDTVKEDPTQPEEQPTEWKKLPTSKDAVNSTEGEAGPPAFVLEMTVSSGTYVRSIVHDLAIAAGSAAHVQTLTRTRQGEWSIDSSPAHAQSDAKQIVPGNCIEWKLFADAIADMQREKSDASYRSPRDDDGLRAWERLLLNTIVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKM7</accession>
    <name>W3VKM7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKM7"/>
    <dbReference type="HOGENOM" id="CLU_014632_0_0_1"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="465"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="914" mass="98515" checksum="6F426531D6F31234" modified="2014-03-19" version="1">MKGNNELESRLARFRVQSQPSFAALGAPAGCLSAGLDPTLARPSLALSQSQPASLFQGIRARGLASDARVEAGFSTTAKPRPNLGRRARATKAHLKFLLGVSSRDGIPGFGRAEDSPTLQHSAFLFYPQSLRAPPLFQSIASRLCRCQELGDEWTLSALGLVTSQESLSRFQRQFPVEGKHACTDAPCRLSSIAISAKVSFHLRLQTLHQQSTSELTCYRKGILENGEPNYSLVRRLAAAMPSSSSSNPRRQASLEPSTSAQRDHPSDTRDQSRRHFRRQLQEQCLQPSGLARASACDSRAEAWLELLDISPERINNHKDSGSEAASTDGTVVFPLSSKSAPSIIDDTLNASVPLDKDGWQLAGSAILNHTVPADSDAGGSDHRSTVTAAQFKATNSEWKVVESKRTKRRKGGQFTTSQSPTASPDLTHSPRLSTGPSDTSDPSSPFISPHLADTSVTATPPSETLPPASPRPYQPRFPNLSERDVEQVAKDVDRSFIGPAFKNVFKSQAEGQEERSLRRKQLTHLVLTTLSRHPTLHYFQGYHDILSVVLLTLASTSPLASAAGLFADDDQEALVELVAERISLHLIRDSMTPDLLPVMGQLKVLGNLLRLCDPPLAELVDRASPLPFFALPWLLTLLTHDAPNVAIMQRVLEFVIAHGPASAIYVCAAVVRSRRDEILAMDADELDDPAMLHAILSRLPRIVADGDDQRSDKSGAAGVAEETSMYTDPDVELPSLANDRALAASDEEKENVKDSGTSISSLLQEAVQLMRRFELDSADVGAHTIMGPKSVLFTWSSTFTPPGSAHDIEWAEMNAAAEAALSGPTDAIVLDPHPPQPEAPPGSDEKPSPLPPTHVGAHHARTLALVGISGILVAALWTASQTAPNAAMSNDQTKRVLTLIVSLLSNFGRVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKQ0</accession>
    <name>W3VKQ0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-catalytic module family expn protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKQ0"/>
    <dbReference type="HOGENOM" id="CLU_1225465_0_0_1"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834625" evidence="3">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="204" mass="22180" checksum="57B47EAC70E5346D" modified="2014-03-19" version="1">MRIVAWTIFSSLLVATASAQLSAGSSSSVLLDSRDLSSTAGSTLQLEPRDEEVEIDIEEVDEEDDQDDAIEARGRRKPHHRNHKHSRAGRKKNKHKANHATPSPSGGKGRFHGKGTFFKPNQGSCGKWNTVNDHIVALSSDIYQGGSHCFKGVNICHGSKCANAYVADLCPGCKKTSLDMTPSLFKELADTNLGVIDIQWSFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL05</accession>
    <name>W3VL05_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL05"/>
    <dbReference type="HOGENOM" id="CLU_008136_1_0_1"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000313">
        <property type="entry name" value="Importin beta-2 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000402">
        <property type="entry name" value="Related to importin beta-2 subunit (Transportin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="927" mass="102336" checksum="3074E1A42D7C22A6" modified="2014-03-19" version="1">MTSTWQPSQDGLAELVQLFRDSQSPQMDVQERIAQRLDAVSQIPDYANYCVFTLTSLTTEDLATRSVAGLILKNHILFHHDLISPESFEYVKQAIIPALSLPEDMLRRTATQVVSMLMTILTPQGWPEGLSKLGELMGSQNTDEAEGAFSSLAKICEDIPRELELCEINGVKPIDILIPNFINATQHADSRLRMHALNCLNQFVQIGSTALQAHIDAFLAALFKRASDESANVRRYVCQALVLILGVRPDKLIPEMDNVVEYMLYSTQDKDDDVSLEACEFWLQFAEEPSLKDKLRPYLAKVAPVLLKGMVYNELDLLMLGGDEDDAAVPDRAEDIKPRHYGGGGAHRNEHLDDAAAANGGAAATGKSRAAIEAQDDEEDDFDEDDEDDEDDDGISDWNLRKCSAAALDVMAVNFGDELLEILLPYLKERLFSDDWLQRECGILALGAIAEGCIAGIQPHLPTLVPFLINSLKDSKPLVRSITCWTLGRYSSWCVAAETPEHQQQFFVPAMEGLLSMVLDNNKRVQEAGCSAFATLEEEAGRNLEPFLEPVLKTLVYAFDKYQQKNLLILYDALGTLADSVGSALNRPEYVEIVMPPLIAKWQGLHDTDPDLIPLLECMSSVTIAVGPGFLPYSPPVFQRCVGIVHDNLAAAEAEAQKPAVEQDVPDRTFIIVALDLLSGLTQGLNTAVRDLVAGSQPSLLPLLGHCITNVEAPVRQSAYALLGDLAISCFDLLKPYLPALMPELIRQIEPEPKMENVSVCNNAAWAVGEIALQYGSDAELTQWVDELIKRLVPVLLSTKSVKSLSENAAVTIGRLGLVQPQLVAPHLDVFIESWCQALWDIKDNDEKDSAFRGLCEMIQVNPNGAAKGFVYFCNAVVRWSTPSAELNDMFRKILTGFRDMSGPQWDVQKAQFPPVIVQRLADRYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL64</accession>
    <name>W3VL64_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL64"/>
    <dbReference type="HOGENOM" id="CLU_2672115_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="75" mass="7832" checksum="64150F0258A49C7B" modified="2014-03-19" version="1">MLPLATIMARPSADELILGRAVLDTVSLNDTGLHAARGDGLSPCFSQAQQQAPQGPSPELEQIKLAQHSGGRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL89</accession>
    <name>W3VL89_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL89"/>
    <dbReference type="HOGENOM" id="CLU_034871_0_0_1"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="268"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="185"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="470" mass="49644" checksum="C2457D92C2833F4F" modified="2014-03-19" version="1">MHSTTGRLAQGRPAGQQQQQQQTASTSEVIVAAVARQPAPLPRASALAAPSADSHLGTASPPELDTAESPALSGRSYSPVATPPALGTIDEHDAALVDFSTVFGEPSSSLLTAPSHAAGASQAIKFEDDSDQMLSFFRTSPFRTTQYESATIDPHVVEHGSLAQPTSLQSTLAMPLDSISPSQLAAAQANPFNAAAESSLKHEHHNRDDSAAPMSEDGMSEDDDDDDEHDGEHRRSKSSGMGKTLSTIPMAVGDTNYLKPDPEEYKKLSSKEKRQLRNKISARNFRTRRKEYINQLEDQIADRDALIEGLRQQISQLSVENKSLKDEVRTIKARTISSQDVGKILEALQTMTSTANNPTAAAAGNGGALNVSGDVASGRSSPTNEFGGAPSGVLTPGAFLNFGSDASRPGTPTFALPGSPRAQSPRPSLLRRSSPSLMPQANTKKDVAPSSSFWGGVGSVNATNTFMPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLA1</accession>
    <name>W3VLA1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLA1"/>
    <dbReference type="HOGENOM" id="CLU_041041_2_1_1"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000009">
        <property type="entry name" value="Putative Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="4">
        <location>
            <begin position="114"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="419" mass="46261" checksum="23128D39DAA6EBAE" modified="2014-03-19" version="1">MLSTLPAGSGHFSAPTGSGAGDGDGAGGFSASQIEAQRSLKSSIQELTSGQHDAIPSLLTPYSSLPRRISGPTVWDAASYTGAENRAKWVHTFTERQIAQLEAAAQLWLESGRELGEIERSTFPLPSDLIATLTQLRQRLVEGHGFYLFKGLPTKRWGNRLSAIAYLGLGSYLGNIVSQNRYGHVLGHVKDLGEDPTAIDKVRIYRTNARQFFHTDSSGGIVGLLCLHKAVEGGESDIVSSHAVWNHLQEHRPDVAELLASNIWHFDRKGEVNSDQNGWVTRPIVHLRKGQPENRLILTYDPYYLKSIQRHVDAGHIPALSEAQKEAMQVLEDTAKLLSLHMVLDVGDVQFVSDVHVLHARTEYKDPAPPAPRRHLYRLWLAVPTAEGGWQNAYPDNDLQRRGGIQVNDTKPTYPLDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLB5</accession>
    <name>W3VLB5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLB5"/>
    <dbReference type="HOGENOM" id="CLU_257326_0_0_1"/>
    <dbReference type="OrthoDB" id="2590590at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1189" mass="126046" checksum="D4DF0BC3F40EC6D4" modified="2014-03-19" version="1">MNNPQSRSDDQLDSPLLPPQPLAASSHELPPRYDSHQFPPTPPAIATHHASHDYFQLNPHSPADSRASTDPAVANVPSPPRAFGSRFPRWGTWLEKRALERHYADVDQQLTPHSHAQRISDELPNRRKKSWGAWVDGPDAINDEASSHSTTQPQASGHATHAPPLHLHHFGSRFIPHLPAQPLCSILISLPSPSHSSPRQVLLLGTHLGLFAVEFHPSQSPSTQTANDAIRCTHIWSGLAVYQMCLLASDDRRATTRNANPRPLTPPSGVLLALTCPSSAKDGFLSSSLMQLSAHAGSVLESVAAAGVTPSTSSSSSHSAHALPVGDESIAAANFGPATGGGPGRAVPPAGTGLVRMWHLQAIRQLLIYALDTPHANTPIHLDTPAESIPPKRDGLGTILKKTFTRQKVRNIAKSSQHSRAGSSASFGDAIDPMPLPNVHADPARDRMSGSSSTRSSLDAHQQQASYTDRQASAGPIRHGRPPLSPAESRQADAAHAAALSLAMGSVPIQQPSHSASVSPSSNASSSSFADTASSLGRQAGHKAKERDTSSQGALFFSVHEASADTKGAGTWYLAITYARSVMVYEAPLPTTGTSRAWSFVKELYAPFPIKAVAFAPAAVSDDPLSPTAPGALLPGKGPTKLRVASPHGPLLTSKKGPQREPSYSTGAAPGAQGVGPARVPRGSAAPASWRKADLCLLLSFGRRAALIRLRDSEVRDFDLTPLAQLTAAADGSDGLSPPQLSLQLPRPETQVNADGARLLHVPGEGSTRADGQAPSSIGHTRQGSVEQRIREAILDKRSNKHHWIGFSTIEARILVRQEADIENPTPSGPYHQESASRLSPTGISLRKPTWSTSSLGHADMNKALPLAPVNQNASFEKRFSRVHLSDQNAQYHDAIQTADSSGSGSDSSDDDFRHQIGKKYQLTDPGPIQRRSRRAQQPKRSQSGPSAELVSAKMAIASKANFTHVLALPLVAAESSVPLAVMQWSNTPNAVSGWARVLGVERASSTGAMPLNHLKPAGLEPSFFDRPAGSQGGRRDEQLVLHVGVTCVAFLASRIESRKVSFKLPVSVGFRMSARTELELAPVSDVAYSRAYLESESGHSSVSPEDGSYPGAGTSVRADSLGQELEYLCGPLLTLPPADLDARSCGAHEVAPAAPHALVPDGTGDATVVAFDWRGADDFRIFTLGIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLD3</accession>
    <name>W3VLD3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation elongation factor EFTs/EF1B dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLD3"/>
    <dbReference type="HOGENOM" id="CLU_047155_4_1_1"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="4">
        <location>
            <begin position="149"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="446" mass="46398" checksum="05620B4E1BF37473" modified="2014-03-19" version="1">MSTSASVFRIARFAAMRSARIAPSSSRCFSRTALVGEPKKPSIKAIAELRKLMPGTSMIKAKEALLASRPASSPDEDSIEAALEWLEADRRKSGAKKADKVAGRQAREGIVAVTVLSDGLPSAVELKGQLKDQAVSAGIGATGAAAGGIVEVNCETDFVAKNDVFTQLVKDIVHTVALFPALTNPTGAEDGFVQIPVDQLLAFPLLPSSPEAQGSSVAPKTVGSAIIDVVSRLGEKISIARAAAIPPPQTPSADAPRRSETGMDRGASVLNLASAFAHGGSAGFAPAKDAAKPGYVLTSGKVASLLTTRFASPQLPDLLASSSDDVQINIRALTRSLARQAAGMQTKSIKAHADNNAEVQGEVSTALYDQPFMMLLPAAAPSPESSAHPVQDVLRSWAIHNKLESSDADAVQVLDMHRWEVGETAAPVEASADDFAQEVRKAAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLI2</accession>
    <name>W3VLI2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferrichrome siderophore peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000092_1_0_1"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="795"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1943"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3016"/>
            <end position="3089"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3572"/>
            <end position="3648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="3545"/>
            <end position="3573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="3551"/>
            <end position="3567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="4093" mass="445724" checksum="5CDD20170CF9C22F" modified="2014-03-19" version="1">MSHAPFPDVTGLRTSGPGFSRVGQHCKLLQVQHSLPLPPSSALAFAQHDLSLAILSAWSAILFHYGSHEASNIEVLHIPHQGTESILALDFDKQRELTDYTPAQLASTVDAARQRRTPTDSLELGYAAFYEAADAHQPSSRFDQLELSTRPEISLALSFHLPQPDQLLLELKAAPAVHSEQSALLQLRQVAALLESYRADAHQHALSVERFDWSLRAADNPNYAHLPDPEHLQGQHADRLETEFEYFANTTPDALALDFRFDLNDHRSTKWTYAEMNQRAEKVKQLLWSHGIGSASSDPNQDHIVALYLEKSPETYLSFIGVLKAGAAWCPIDTDWPASRRQALLAKSNAKVVLTHDDNISKQLQDDLQSDDVKSKGGMKAIRLDQLDDELQHIHTPAEPFDSRDIHQLAYMIWTSGTTGLPKGVGIQHEAIIQAMRALRLYIPYGKDKIGTDQIRYLQYSAYNFDLSIMDCFYTWGLGGTICSCPRGVLLQDLVEVGNSIQPTHTLLTPAVMAMTERHRVPSLKVVISGGEKLSQVVADEWSKDCCLLNLYGPAEATLIAMNRRVPFGDRVKAPNIGVALPTVSCHALDKHDRVVIKGAVGELVLGGPQLARGYVGDPVKTADKFFPHPQLGRVYRTGDLVRQLDNQEFEYLGRIDDQVKINGIRIELLEINAAIKNSHDHIKDSETMAFPKKDNESEQQIINFSALPGGNPGELLRTDDDAVSVARQLQINAKQNLPSYMVPNLFVILSHFPRTSSAKIDRVALKNVLATFDQLDWENKLANDGDADEQAQPSEAEACLRKWLAKLCNVDAAKIGRKTPFTSVGLDSIRAMSFSQRVSQEGFSVSVLDVARYPTLKALGEHLASSQSSSTERAERAAEFLARWDAAFRQPVVQWLRQKAESKCDGAEIQSVLPCTPLQEGMLAESQRDASSYRIQRQYQLPAGCELDRLRHALIRTVENFDSMRTSFVDVGSLDVDTGSQQWPFQPHFLQVVWKHCTPVIEQFHIGEDDDCEQAILASAKSLRLDPFGDVPPVAFLLVTQGSQSSLVFVAHHSTYDARSLGIFEDYVEALYEGQPPPPSQQFSAALSHILPIDESEARRHSDIWTQALASYPKGESVHFPVLSLIKPPQGDAAEANLHESRYRQASVTWKDVEAVGRRLGVSARPLIQTAWAVVLSAYIESQHLVLGDSVSGRTASAELDQVYGPVLSTVPVPFVLRPEQTLESLVKDTHSFHASVMEAQHTDLGAIRKMLQVAPGEPLFHSVFVLEPAPSPENEADEAHFRLSKLADLAVATEHELGVEVLPASDGSIQLGLSWHKSLVSTAFGTLLLDQFDRSIAALCASSDTKIEAFLRDSSQDKEQQHRLYSITEESSSKTDRSATFSGVADALNREAIADKRCAVEVYHEVADSASHRRAAASISYPELEQASQGVASLLRHLPRNSVVGVCLERSLESYIAPLAILKAGHAYLPLDSTLPVERKRELLQDSGAALLISSGDDLVPEAPVGLERLNTQSDRFRGAVHAVQGGDEVQAAMVSPDDVAFIIYTSGSTGKPKGCLLTQANLAAAIDGFHTSYEREAPGSFEPPARFLARSAEAFDVHLLEIFLSLRVGATIVTGSRALVHDDIAKTMATLEITHACVVPSLFFSKGDRVKPADVPSLRALIIGGEALTQDLCQLWGSDGAERPVVLNAYGPSEATIGNSVARVSKRSRPNNIGRPFPGSQYLVLKQISGRLVPTLRGEPGELYIGGEQVAQGYLNRPDSDSFVEYNEQRVYRTGDMVRLHPSDEAEYLGRMDGSQVKVRGARLELGEVDAALSTCLNEELGQGGAAVTIHSDHPKLEGPARLVSFFAPQTARLKQDEVQDKSSLLLQDGQAAARAAELRRRVRARLPQYIVPSIVLPLALLPIASLSGKADRRLLKELYHSIDPSRLADAGASSDQPKRELTDSEQAVAAIVKASIRLASEVKLTHDLDLIMAGLDSLSVVTLSSRLRSKGFHISVASIMNDPTIEAIARQARNSDVASTNQGQEKWDKRVSDLTSKARELPQFSQIAVEMALPCVPMQTALISQAIANESSTPPYITTITIDVASREYSLEQIRDAWLGTLARHAIYRTVFAEVEQNLVQVVLAPEAVQASWSVGEVAIPTGPELAQYHSKTAREIVASMDEKPALRLKLWRGPNATPVLSLTCSHAIYDGDSIRMLLQEASGRLTGTPKDSQATPFAAAARVIVGDADDGAAKKFWSDMLSGFSLNPVPNLTGVRPETQASRSKELAIASSIPFSKLEAVARAGKVTVQSLLVAAYASLLGLYVGEDDVTLGLVLSGRSVPVDDIASIHGPCVTTVPLRLTDARSAKLDQLSTRAHRAINALLPYQHTSLPQLMRWLDLSRTPFEALFSYLGQSEATSQPPLFSEASTQMERDYPLAIEISATDDAISLHLAFDARLIPAEQANLMLAQYEQLLHTLIDSEPKDEHLSILNKDCYVPANSSETIISRFAEHARETPDAPAVVFASNMQEAPRTTSYAELDQMSSNIASHLVGKPGKFIGIHLHKEGPELYAAILAVWKAGKAYLPLDPTLPSERLAYMIESVDDCPVIASRTTSKGLADFSCEVLDLADLVATRCDEQLPSISLDDPCYLLFTSGSTGKPKAVQINHRAMAGALFSWERMLPFTKQSRFLQLASIGFDVSLIEVCMPLSLGFSIGTAPKQELLEDLTHAIQHLGITIADLPAALAGTVHPDDVQLEWLMSGGDVIDSRVVDEWSRAGRLLINAWGPTEATIGNTLGPVKPGATRNAIGHVYPASALYVLEEGSKRILPSGAIGELVVGGPQVADCYYGREELTAEKFIRLEDGSRVYRTGDLGRFLHDGTVECLGRIGSDRQVKVNGQRMELDEVCAVLAGQAGVHDADVQYLKHPSMGSKQLVAFVAPAESRPANGDMHAREDDAAMQLCVQLEQEASKRLAAYMVPTHWIVTSSALPLTHNNKTDHKALAAFYEQIDAALLRSLGAKREGASSNHAWTETEERLRKQIAEYCDVAEDEVTRNTSFHRLGIDSISAIRLVKQLRKLGYSFTVADVLSTPNIAALAERQAQNSDVSVNGHSSQAGLKEWTKRVEETAAADGWKLDADESIVSILPCTPLQTGMIAQSLASGGSLYFHHHAFQLRGLSPEHVSAAWTKLVERLDILRTSFHAVEGEHAWAQTVHSRIEPRIVMHTGSMARRDLHTLDGQLSFEDEQAFRRPPHVLHVWPAHDDSLALMLSIHHALYDGTSLPQLLDDFECLLFGDEQRLFARLPFHELAPSLLSREEDVQHWSHALAGFQPCLLAPQPSQRGSAVLVERQLGVTASELESRCRTLGVSPQVLCNLAFAKLLTLESGSRDVCFGQLFGLLDLVPEADTAVGPAFNSVATRIRFASLDEPVKTVAAALQTANDAGRAHRRAALRDVQAAMGQGQLFDALFDYQRAYDDAESKLQPVELQAEDEAAQYTLNVAFVQGPSRVSIVAKADSARFDRAGLEEMVQRLEALLEHAATRADERVSALPDACKSLAFPQHLPAETNGTRTASVNGTSNGTSDGKHAELDRDGQKLAAIIAQVAGIEAHALHGETQLASLGLDSVSAIRIASQARRAGLRLGMGEIVAAPTINALVSRSAPRTNGHGANGTASKPHVSPALAERVAAELGVEASEIECVLPKLWLAAWAQKAGAGGFSFAYRLPGLDAQRARTTWAHLRATHAILRTALLVGNGSEAQVVLAAKALGETPHFEEAHVGEENVDATVRQVVAQQAAAGWKTLRVPPVKLTVVGDVLVFSLHHVVYDAFSIEALVRNFAALYHGRSPRSAASWVEAVQHVAREQDALVRSGDAQRFWAEALSGGESAVLSASAAAGGESFESLKGAIRVSDDVETRLRAARVSLPALVLAAWATELGARLELQPDAAPLFGLYQLGRSTSFEGIDTVQGPLLNMLPMRLHGAMLVDRARSAVVQLRERARYEQTSLSDAHAWAGLQPHAYNTAVNVLLDSPGDGADEMQPVDIGVPTEYAGVQQQSAEEVWQPKVSVDVVLTRGGVDLAVKAAHEALEAQQLKGLLVSLTRRIQHALDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLK5</accession>
    <name>W3VLK5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLK5"/>
    <dbReference type="HOGENOM" id="CLU_035750_5_2_1"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="222" mass="23811" checksum="A785A0D208EFFE3B" modified="2014-03-19" version="1">MAVNGMDITGHLKKGEVDLGTSIMAVAYDKGVILGADSRTTMGSYIANRVTDKLTHLSDRIYCCRSGSAADTQAIADIVTYYLDMYAVQSGNPVETKVAANLFQEIVYGNKDRLSAGIIVAGWDKQNGGSVFNIPLGGGVFQQPWAIGGSGSTYIYGYCDATWKAGWGREKTLEFVKNALALAMRRDGSSGGTIRLVDISEDGVERHFVPGDQLPELADKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLL2</accession>
    <name>W3VLL2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03488</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLL2"/>
    <dbReference type="HOGENOM" id="CLU_011131_2_2_1"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="13">
        <location>
            <begin position="166"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="696" mass="79232" checksum="181AE4DD796608EB" modified="2014-03-19" version="1">MSAASSSSVAAPPDYTKATDGTGVIGGDPWLEPFAPALRERYALYQDWKSKISASEGGLEAFSGSYRNMGFQVDPKTQAVTYTEWAPNAVEAALIGDFNNWSRDSHKMSKDDYGKWHITIPPLANATCAIPHDSKLKISMLLPSGERIERLPAWILRVTQDLDVSPVYDARFWNPPKEERYTIKNPKPPKPDNIKVYEAHVGIATPEARVGQFKEFTKNVLPRIKELGYNTIQLMAIQEHAYYASFGYQVTNFFAASSRYGNPEDLKELIDVAHSMGITVLLDIVHSHACKNVLDGLNMFDGTDHLYFHEGAKGRHELWDSRLFNYGHHEVLRFLLSNCLFWMEEYGFDGFRFDGVTSMLYTHHGIGTGFSGGYHEYFGPSVDVEAVVYLMLANDMIHKYNPNAITIAEDVSGMPALCRPVSEGGVGFDYRLSMAVPDMWIKLLKEKADEDWDFGNICFTLTNRRHLEKSIAYAESHDQALVGDKTLAFWLMDKEMYTNMSDLTERTAIIDRGLAYHKMIRLITHALGGEGYLNFIGNEFGHPEWLDFPREGNGNSFHYARRQFNLVDDRLLRYQYLYAFDAAMNNAEGKYKWLASSQAYISLKHESDRVVAFERAGLLFVFNWHANNSYTDYRIGVDVPGKYKVLLDTDAKELGGHGRIDHNTEWFTTDMEWNGRRNFVQLYLPSRSAIVLYRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLL6</accession>
    <name>W3VLL6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLL6"/>
    <dbReference type="HOGENOM" id="CLU_067676_1_2_1"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31279" checksum="115568AABCE116CB" modified="2014-03-19" version="1">MSDTIELPVEAPLTSASKLLSGVLSQLDSSRAPTAEQLRQLQLVQTLLSGMDAYLDSVSSPAPAVQRPLLQATAEHDWQAAWDNKQTLFHLSAAWSAGAYEGNLVGMLTKLMRAKKVLEIGMFTGTTTVCIANQLPQGGKVTALEIDPYLDAFTRPLFDKTGLGDKIDVKVGNAVEELDKIARNVLSDQEAFDVIFIDADKPAYTTYLHAILDKGLLKRNGLLVVDNTLYKGTPWTEGLVDEKTLEIGKQNAEAIKQFNQVVRADKRVEVVVLPVRDGVSLIMRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLP4</accession>
    <name>W3VLP4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl hydrolase family 30 TIM-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLP4"/>
    <dbReference type="HOGENOM" id="CLU_014379_2_0_1"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="6">
        <location>
            <begin position="187"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="641" mass="69933" checksum="4143B1B592C69E88" modified="2014-03-19" version="1">MLRTKDDLRVQIQAYKVPALYVCSSIPLLTFSAFPGAMKVIALAAAWVAACAQLAHAEIVIDRMWSTTYDYSKVQELSNPQIKFVDGQALAASVNVTAAASVKSQQYDAIGIQVQENQLAQLVDTFGGGVTDSVAITLQDFKSKHPKDYDDLLHLLFSQDAEWHAKGGVGLNTAPKLWQTLHDIVAIHPGLKIISAPWSAPGWMKDGADETQPLFGGSLKVGMEEVYANYLVKAVSEIKAQEKLDIYALTLLNEPQIPELQYPTMKLSAAQAIQVGKLVRTALNKQGFEKVKLLTWDHNWDNTDYALQVLNADPTQWDGTAWHGYAGKPSSQKIVHDAYPDKETYFTEYTVISQYFSEPYKNMKNTARNLLIGSIRYYSRSVVLWNLVLRKDEDGFTTPHLPNVCQNCNAAVLLLPDSTDALAAADPSHTKTVAEAAGAAKKDKRRRRSLWRRADDTKPDTTTEELKPQTGSPAVAGGGEKAEAIQAKDVVDAKKTGTNSVYETALFKRSSDYSVLSHLSAAVRPTGASKEYSKRIGVSSTDEITELGGRLLAQAFRQDGVKPGVSRFSLILLNQNDHYETDVWENATAVIGFRGQIANVTTLPGLYTLSWEAPTVDTSAAAKAPLPAKADAPAADAKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLX1</accession>
    <name>W3VLX1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal specific transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLX1"/>
    <dbReference type="HOGENOM" id="CLU_093522_4_2_1"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="9822" checksum="8066F2915DBEA052" modified="2014-03-19" version="1">MSDASQPSEPSKAAPLGLPAPGDATADAQPNVIKLDHLGPMIVNSDGTISRIANWSAMSQIEKDRSLRLLAKRNNARMESLKADPKNEAQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM35</accession>
    <name>W3VM35_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM35"/>
    <dbReference type="HOGENOM" id="CLU_040695_0_0_1"/>
    <dbReference type="OrthoDB" id="416752at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17769">
        <property type="entry name" value="NP_TgUP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF14">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="352" mass="38099" checksum="0EC9C5C8F2E2FC12" modified="2014-03-19" version="1">MKDVLSNANFPQDAQGRTYHVATKAGQVANRIITVGDQVRAHRIAKAFDGGKPLFEFNSQRNFLTLTGTFKGVPISIVAIGMGFSVVDFFVRECRAVVEGEMIIVRLGSCGSLQPEYGIGTVVVPKASFGISRNYDYFHHDTTADERRSGALEPYLITKPLDADQEVHDALLAALEADKPKNSAELFGGEEVKAAGDTVNASADSFYGSQGRIDPAFVDANANLIDVIRERRPGVATLEMETFLLNHLAAAANDAIDLAQKNGEQPVHKGKIRTGAVQMMCVPNSPASNTRADTDRSLARNSFANRNTSAFISPEQCETLEHWAGKSVLTALANIQIPNERLHPSGVWNQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM54</accession>
    <name>W3VM54_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM54"/>
    <dbReference type="HOGENOM" id="CLU_006533_1_0_1"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="319"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase-like" evidence="7">
        <location>
            <begin position="817"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="676"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="884"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="103202" checksum="0E647EB67697B674" modified="2014-03-19" version="1">MSRSALRDAAAIASTICHIAKDVVLSPGGSRAAAPRGPLRPWPTQQVGKHASDDANSSTSGTPPDRPGLSSDLDSAAKASPESRPPARPWPTRTEAAKPTAPIDAAPVQETPPWHGVQQSPPPIESRTPVMGSQDPVPPITPSVPTPVALDPSPPRVDCAPPKVAQGPPKPSILPFKAEAATDQASSVPPTPLPPKPSAPAEPIHSGIIDESEEYDAVKESKHVPLRAAKVPSSRIGRLFHYGGLGAGLAFGAAGSLLRGASSSADGAATNSVFMSEQNVARLVDKLSTMRGAALKLGQFLSIQETKLLPPQIEQVLLRVQNSANYMPIWQMNKVMSQELGGADWRERNFKEFDDIPFASASIGQVHSAVLRDDFPDAELAGKKVAVKVQFPGVLESIDSDLSYLRWLVSASALLPKGLFLENTLRVLGRELKDECDYEREAEMGRRFRAILHDSREFEVPKVVDGLCTSKVLTTEMMRGRPLSMASRYPQATRDRIAQSILNLSLSELFRFRLMQTDPNWSNFLYNERTGKIQLIDFGATREYSKEFMDNWLQMLQAAVASDYDSCLIWSRKVGYLTGDESAAMEQAHVESMIALGEPFRPDAPDPYPFEHQTITDRVKAQIPLMLRERLTPPPQETYSLNRKLSGAFLLCARLKAHVSCRQLFEQVEADYTFGPEPSRSQTASSSAATTTSFGSAEQRRQFHTAFRRAREGPSSVAPTRKHGRNLLDRFPRSKVVLSDEAAATSQGSSEIGDRVESLAAAPTASPSMQETPANAVEADSTEGIDVARSATPAEVTPAPAAAAATSGANVSMGPTTIRGIVIPLKPPPPGPAECCMSGCAHCAYDIYAEDLEDFHSRLSSVRTQLTQLSPAVTRDEWRTDLLGEYPSASSSDGSVSSDAGSAESEHELRERAQREVDRVIGDLDPTMRAFLEMERKLKKQERERSNAAQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMC9</accession>
    <name>W3VMC9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMC9"/>
    <dbReference type="HOGENOM" id="CLU_089363_1_0_1"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23867" checksum="15F1727EF4D94197" modified="2014-03-19" version="1">MSIVRPKVVDGKWHFFDGALQTYFVREDAESFTSGQIFRANDPHSGVGRSSTATPPYHIHLFQTETFDVKDGTLCYLIDGKHGKLQAGQKVNIPPYRPHTFWSDPESGKDLHVHITVRGGPNPGFDEDFVHNFYGYLSARTMAGKPPNPFQMLRFLDDADVILVPPVPFAGLWRAFGLLWPLGRSINLLFGRIIGGWLLGYPTRYKEFDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMD0</accession>
    <name>W3VMD0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMD0"/>
    <dbReference type="HOGENOM" id="CLU_2334540_0_0_1"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="98" mass="11051" checksum="6357198926DF119A" modified="2014-03-19" version="1">MSLPIRYSLPQRPAVVSAVAIAAWYFGRENPNFANIFGGTANLDKWAHLIARIHVAEAGAMFLYTFYRGADLVTSVKWTLTQLVIGFPSYFHFKKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMD6</accession>
    <name>W3VMD6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS-type efflux pump MMF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannosylerythritol lipids (MELs) biosynthesis cluster protein MMF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_03510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMD6"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000484">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="112"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="630" mass="68506" checksum="15E70DF4F69AA0C1" modified="2014-03-19" version="1">MALSPPHCSTAYHHQKIGLQRCLSSKLVHTFVTVKDTSTSRNPFCHQNATSLRLKDWQADCIDSAVRRHCYSATASGLDNPTRRYTMDDKIALTSNEGERPRMKKDWRFWTIFAALMLIAFLAALDMTMISTALPAIVAALPPSSIAANWVTSAFLLPMVASQPIFGGLSCSLGRKNSVNAALIIFLVGSVVCATAKSMLVLVVGRGVQGLGGGGIHALSEIIMSDLTTLRERGVYFGLIALVFAVAGFIAPVLGGVFSHSNWPWIFWINLPIGAVALVMLVLFLNIRVPLLTGRQKWEKLDLVGNAILFGSVTAVLIAVTEGGIKYRWSDARVWVPLVVGLIGLLAFLVVEWIPGPLCRQPVFPRDLFANRTAAVAYLQTFLHGVIFYGIIYMVPIYFQAIKDRTPLESAIWSFPLTAPSTPLALIAGLLISISGRYKKLIFLGWALMAAGVGWLTHWSVGTSKAEWVISQIIAGAGIGIMFPITLPPIQASLPVERLEAATAAYAFSRTFGAVWGITGATTIFATQAAKNLRPSYAQLNPLGLDDFTIIAFAESLRHLPQELQVLVKKVYADAISDSFWLFVPLAIVGFLSTLLLKDLPLPDFIKSQAVLEEKNESNSQSPSPPESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMQ5</accession>
    <name>W3VMQ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_02599</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cytoplasmic vesicle</location>
            <location evidence="1 14">COPII-coated vesicle membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Peripheral membrane protein</topology>
            <orientation evidence="2 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMQ5"/>
    <dbReference type="HOGENOM" id="CLU_008658_3_0_1"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="17">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="18">
        <location>
            <begin position="147"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="20">
        <location>
            <begin position="441"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="19">
        <location>
            <begin position="556"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="16">
        <location>
            <begin position="670"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS62844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="806" mass="89173" checksum="06D384C46CBA4ED2" modified="2014-03-19" version="1">MLSTAETSRCVWYAHPTDAGADIATMNVDDVEDRDGVRLSWNVWPSSKIEATRTVVPISALYTPLKEREDLPPVLYEPVTCKPPCRAVLNPYCQIDVRGKLWICPFCLSRNAFPPHYKDISSTNLPAELLPKYTTIEYTLSRPAQIPPIFLYVVDTCMDDDDLKALRESLVVSLSLLPPNALVGLITYGTMAQVHELGYDACPKSYVFRGTKDYVFRGTKEYAPKAIQDMLGLNPGARPMGPGAPGAPGGPSQAPRPPNATAQMGASRFLLPVSQCEFQLTQILEQLQKDPWPVANDKRSQRCTGVALSVAVGMLETTFPNTGARVMLFCGGPATEGPGMVVSTELRERIRSHHDIDKDNAKYYKRAIKFYEAMAKRAAGNGHTIDVFAGCLDQVGLLEMKGLCNLTNGHMILADSFQMGIFKQSFHRIFHKDDQGHLQMGFNASLDVQCTKELKVSGLIGHAVSANKKSGCVGETEIGIGQTSAWKLCSLTPRTSAGIYFEVVTPPGQPMQPGSRGLIQFVTHYQHASGQYRLRVTTIARNFAEGGSGQIAASFDQEAAAVLMARIAVFKAEIDDSPDVLRWLDRMLIRLCQKFADYRKDDPTSFRLGENFSIYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNTEDVNNSLIMIQPTLMSYGFEGPPQPVLLDSVSIRPDVVLLLDTFFHILIFHGETVAQWRKAGYQDQEGYENFKEVLENPKADAQDLLADRFPIPRYIVCDQNGSQARFLLSKLNPSTTHMSGGMYGASGGSGAAIFTDDVSLQVFMEHLKRLAVGASSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN29</accession>
    <name>W3VN29_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN29"/>
    <dbReference type="HOGENOM" id="CLU_1074113_0_0_1"/>
    <dbReference type="OrthoDB" id="6246201at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="299" mass="32025" checksum="5D2764A6EE95D872" modified="2014-03-19" version="1">MAIGAMTPFVGPAARAARPSTLQLAASTSLAARESRRSLVSSSTACASASSSSASASPSPRSSRRSARFTSRPGADMVGPPDPISNLRPVRYGSAFEEAASSSSASPNDASSQMGSSASLSMSHPYSLHEFTTSGDSNLGWSGNHARRRGTRSPSVYFERLLAKLEEAELAHKLRMARADNFNQRFWQDNNARFIQALSAFRSRTGSSKAVATLPHAASDTRQAGAAATSTESELDLDSDSLATFYSAWLKANAARHRAYNRQLWRQTFGDLAPAARYQGLRAWAKVVGAVERKMGRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP26</accession>
    <name>W3VP26_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion inner membrane</location>
            <topology evidence="1 7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP26"/>
    <dbReference type="HOGENOM" id="CLU_169812_2_0_1"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000004">
        <property type="entry name" value="Related to COX8-cytochrome-c oxidase chain VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="78" mass="8690" checksum="5BFE91AF58052E22" modified="2014-03-19" version="1">MSILARQTVRSARTAFRQQQAPLLRRNLHVENTHETSLPFPSGPTRKVPVAISLTTFLVVGFSLPFVAAKFQIAKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP93</accession>
    <name>W3VP93_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_03234</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP93"/>
    <dbReference type="HOGENOM" id="CLU_027974_0_1_1"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000005">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS62597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="317" mass="35325" checksum="E0CDC68481FB29B1" modified="2014-03-19" version="1">MAGRIREVWAENLEIEMALLRETIDKYPYVAMDTEFPGIVARPIGTFKGSSDYHYQTLRCNVDLLKLIQLGITLCDENGNLPPDVCTWQFNFRFSINDDMCAPDSLDLLTKAGLDFDRHERMGIDVEHFGELLITSGLALFDDVKWVSFHSGYDFGYLLKVVTCSPLPAQEADFFALLRVWFPCIYDIKFLMRSCKTLKGGLQDVADDLQVSRIGQQHQAGSDSLLTATTFFKMRQKYFDGSIDDSKYLGCLYGFSSSSSHANGMVHYTQGRPVSVQSFHDASSIPRSVSGGYAAAGGYGSNFGSPFKSSLSTSTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPA0</accession>
    <name>W3VPA0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPA0"/>
    <dbReference type="HOGENOM" id="CLU_003373_0_0_1"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000077">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005377779" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="976"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="46"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="297"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="446"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="617"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114251" checksum="05B37CBA7138DB4A" modified="2014-03-19" version="1">MLAHRLLVAAAALACLCTGGAEAAQHPLQLAIEPVIPTRKHNDTSSFNLIDLLSQSPDHTIFVRLLQRTRLIPTINRLQEFDDGSGITILAPTNDAFLSKKQQQLSQLRAASQAASRSDTRAFWEYLLDDLPHTAASAHCIWNDGICIQASNVNAVARQHLLYHVLNYTLPFGLSDDTGSHAPDHPLPQPGKPQMHTTLHFPSRRMLTEPTHPGRVPVPDEEDHGGLLGHQGQRMRIALVNRKDKKSQSDPSSTKQKQPSLYFGADEQGRGGAMSIFEDWRSRSGVIHHIDSVISLPPSLEHVIATHPGLESVRHLMNNDTLHTLSTVPHLTLFMPTSQAFDKLSALESAYLFGDFEQASLDRLKLLGWHSCGSGFGDRSPVYSAALRAAGRATLATALGGSVSIEVDQDDGSIKVMDAHIVQEDILTENGVVHLIDDLILPFGDLDMSIEATLLALNATRFVDLVYEAGLQHYINKPAHLQRHDGDPFTFLAPRDDVIDSWYSRHPHIAPYAPDTTRSLGSYRKGPSLEEVVRYHILPGQIRPANLTSGMLLNTELQDWKLREGRQKMPVQVDDTSASETRGNGDVAFGDANVISEPVEVKDSAVIYVVSQLLQPPSDPIQTAVSYLSLSTFVATVFSSDLKKAVERAPGVSYLVPTNDAFTGLGLAMNYLLLPESQHLLQALVEYHAIDRIAYKADFTDQEAEFPTLLPTLGAKLAIRRQKGGAIAVHQAGDPNGTTSLVIKGDILTNTGVIHEVDRVQIPFDLTIRDLLKGAKADTMEDLMVQAGYEYILNSTIPKNQSVASTSGFLVLVPTDSAFTKVNLTAVLADQDRLVRLVQQHLIPLVDDKSVDELLPDGRGDGIEMKDESSYATLLDRTNGGPSAYGQVSFRRTDPRTSRYKRALSDGEPDEGLGWIVGIKNTRGSSSDAHSAVVTAFGREARGIRGDVRIIRPPAGGVFQIDAVLTPYEPGWFYRWGWIALLCAAVTGAVASLAVFAVRWWRRGKRIQLPEALEGAYSLPYMMADIRLTSLRPVRGNPTGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPJ8</accession>
    <name>W3VPJ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPJ8"/>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="583"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="708" mass="79227" checksum="B2FDFEBB0EEF2294" modified="2014-03-19" version="1">MGGTSLRTGALIGIISAFALRRLPATLVRSPLLSTRPGVLRAAPIRSHLDSLPHTRQHYPSASPSPFSTSAMSSADIALVPSPASFNGAPFLSELPQLPSVPGVDTKRAPLDNFRLAIAKHVSESLGVDVNAAFAAVGTGKIGDYTVAVPRFKLPGKPIEICEKAAAAFQPNEFLSKIEVKAPFLHYFLNDKTLIKLTLQTVHVMTHGFGAPRDDAGNAQPSYGTNRDGEGKNIIVEFSSPNIAKPFHAGHLRSTIIGAFLSNLYKANAWNVSKYNYLGDWGKQFGLLAVGWKLFGDEQRLQDDAVNTLFDVYVRVNQLASVEEDGKGEKIHEEARRYFKGMEDGDAECLALWQKFRDLSIKKYIEVYERLNIHFDVYSGESQVKKENLEKSLEQLRKADFVSKEDNGATLADLTKYKLEKCVIERRDGTPLYITRDIAEAAQRFDNSFNGNGFDKMIYVVASQQDLHLAQFFKVLELMGYPWAQKETSRLLHINFGMILGMSTRKGTVVFLDNILDETRDKMHEVMRANEAKYAQIEDPMRTADIVGMTAVKIQDMSSKRINNYNFDWSRMLSFEGDTGPYLQYNHVRLCSVERKAKESDGLELPTADLDLASINLELISEPKARDLVMLIAQWPDTVRAAMKDHQPSTIVTYAFRLTHLISSCWEFLLVKGQERDLALARLFVFRCCKDVLGSALRLLTITPLERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPP3</accession>
    <name>W3VPP3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Man1/Src1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPP3"/>
    <dbReference type="HOGENOM" id="CLU_010838_1_0_1"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="HeH/LEM" evidence="12">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="11">
        <location>
            <begin position="366"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="83258" checksum="C7B1E92CF352F77A" modified="2014-03-19" version="1">MVERDDYMREGFDPSSLTMPQLRGILVEHDVPFSSAVRKSELVDLFNRNVLPKTASLRKKKATIVASSSGIIDMRDGARSDTEVTPEQTPAKRKPGRPRKSEASTPASQTPAKTPAKSARKKSSLGSQVVAVAESEAEEVVEQPVKRPRGRPRKSVSTEAVEPEETTSPRRVTFGTTPDSPPASSRKAGRLSLGAGGSGRRSDDDGTFSDSNPFQSGSEASPASGIAAKVAASARKARRKTTDGTSTLRKKASDQHLAPSSPRSARKSAPGAGSTLQNYMDQSIASITPPRIVGDNTVASSKDTSTYSGAEADADDDFDDLDTFTSPSALAKMRILRRKKDKQRRKGGRAERTLADHLIRSVWMMVCVGAIAWTMWYARETRALGFCDTGSDTNAIVQDRQLTALAFARANNESVEDTSILPERFQPSCTPCPPHANCAYGQVVGCSSDDWVLQPNLRSHVPLAKWVLPLSMTAPRCYPDTQKLVLASELAQAVSHMLADFKGEIVCGTQKTHATVKKLPKKLVAENGNLTYAIAEQAVKRSMSATRDARVDDDYFEQIWYMALFELTDPRSNIVRVPVSAASPAQAAEEADELQTEYFLAAKQPTLTLACRSRLALRGWMMRARLYVFALLSAVLGLSYLRYRVSAARAETAKVATLVQAALERLQEQEYLHGLDPVLYPDDFVPLSHLRDHILSEEHQAKARNRLWKKVARVVEENSNVRTRQAQKKGEWLRVWQWVGVESFKGYSGTPTLTPQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPR5</accession>
    <name>W3VPR5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPR5"/>
    <dbReference type="HOGENOM" id="CLU_025885_1_3_1"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="165"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="527" mass="56698" checksum="61F90C54A668B073" modified="2014-03-19" version="1">MTPRKALKTAVEAVASSSTLRRSSRRSASSASTTVQQSPKENPIPNATTSSVRQLPPSTKRQKVDSESDAPSPQVAPSSQARRRVKAEPPAPPIKQEPETDEVKPAPAIKRRRTKKEVDEAEIFPPRPPPVSAAVSGGAGAPRGLYIGAHISSAGGVENAPLNALRIGANAFSCFVRPKMQWASTPIADTSAELFKQRVLDHSFMPAPAKSSALGSAPPDGFVVPHGCYLVNLANPDEAKRDKSFEAFMDDLRRCELLGIRLFNFHPGSMTAASVADAPVEERVNGVRPAKAEACATVASYINRAHALTRSVTILVENMAGSKNDTLLGSSLSDLACILSHVKDRSRVGVCIDTCHAFAAGYDLTTPQAYADFAAEIDRTLGWKCVKAMHLNDSKFGLGCRRDRHENIGRGCIGIGGFWNIVNDPRCADIPLILETPALGAASAAYAAKEATVKMHQVWSFQIQALHALRGTEWGKWKEAEEWLAKADQVIIQAAAAHAVKKRSSNQPTKARKKAHDAEESELSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPU7</accession>
    <name>W3VPU7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPU7"/>
    <dbReference type="HOGENOM" id="CLU_074390_1_2_1"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25900" checksum="F611F7BD7F52A03C" modified="2014-03-19" version="1">MKAIQALRGVARPGRMATSVPRHAVKPVMARFSTSALSRMPSDDPGGKPNTGQHRTVYDDFYNILAPATPSTSIVIASTSPTTITLQDGLVLSEPVVILNNQVFLFDHPQLNQDYATPSGIGWEAWIDQQVKAGKKLEVTQKVKDVLGIFEVVDERPEIILFGTGKRVLPPPTPIRQYLNELGIQLDVQSTHDAASTFNMLSEEGRKVAAILIPAEPSEKVRYTPQQLERLLAGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQB7</accession>
    <name>W3VQB7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQB7"/>
    <dbReference type="HOGENOM" id="CLU_169286_3_2_1"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF1">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="81" mass="9459" checksum="9A4B8D51C9BB9E0C" modified="2014-03-19" version="1">MHPHLVGDSKLQHCAHLIQALNECHAKGVWHKITGGCNGIKHDLNMCLRQERVERTANHIRESRENRKKTEQIWKQIDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQB9</accession>
    <name>W3VQB9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQB9"/>
    <dbReference type="HOGENOM" id="CLU_1166272_0_0_1"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="238" mass="26697" checksum="1B8E7186A1784EBF" modified="2014-03-19" version="1">MGNSSNPAHKAGVARSGSYPSPTDPCRRQHFSRFGRNTHQHPPTVAVSISNYMRRIRPHALARIEETGSTEMVVSTRLGSTVGFRQDVVADVASCKCKSPAAIRLWTGAVGAQACRQDQAPWIIAGLVQEYWPTISDAVSLRLVWGINRGHQTERRVLAPRPSNRKGRQGERVKVIRSVVREVAGFAPYERRAMELIRNSKDKRARKFIKRRVGTLRRAKNKMESLTNVIAEQRRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQD6</accession>
    <name>W3VQD6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQD6"/>
    <dbReference type="HOGENOM" id="CLU_023062_7_0_1"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="530" mass="54886" checksum="D799BCC0A9D1EE13" modified="2014-03-19" version="1">MTDGPSKDELVEIFKSLKATQKGNKVCFDCGAKNPTWASATYAIYICLDCSSVHRNMGVHITFVRSTNLDSWHWSQLRLMKVGGNAAAAEFFNKKGGAHLLAPSTEGKVKYTSSVALAYKDELQKRALQDAAGQSLNSPVFFAGLAAPAADKAAVAAKTNAGSGDMDDFFDEWDKPAGSAKAPAAKPAPAVAAPVVRAAPAPAAAPKTVTSASLRASSSAARTKTLGAVSRTSSASSTPGTTTPTGNGPTSTAPAAAARPVRVGKLGLGAKKAGAPIDFAAAERKAREEEAARAAEAKAAEEAEAKARESQKASEQQAEAERIAREAVKAAVGKAGAPASPASKAGASGARSAAASAPDAFAAAKANGDMDRLGMGFGRLGMKANAHQAKLAAERAAAAANNATTTDSDAGGDEPSYARNKFSSQKSISSDQYFQRGSYDPQATSEAQQRLQGFQGQTSISSNQYFGRDDEEEAEQMPAQSGDFGDIEATAREYYQRFMANPDVQSSIDSFRSGALKLSQYLEDLSRNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQE3</accession>
    <name>W3VQE3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02778</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQE3"/>
    <dbReference type="HOGENOM" id="CLU_004914_3_2_1"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Hcy-binding" evidence="8">
        <location>
            <begin position="138"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="570" mass="62346" checksum="97C91DC4C3DAF187" modified="2014-03-19" version="1">MQPCPTCRRHDQLARAAGSPAAAKALFKSRLHIVGRRSTVRERGATNAVLQNLRDVRSRLRSSKMRDSDKIAGGQQTAEKLSANNELRKISRREAKDRGCEVLPNDIIIVIVIFFVFFTIAFTSPFGRLDMTAPINQSGLEALLDSSRIGVLDGGLATYLEDGLNFDLSKGPLWSARLLDEKEEDVSNGKGQKGIFDAHLHYLQAGAGIIGTSTYQASLESFERAQYDQESASRIMSKAVDLACEAVNTYNSGSNAVRPLISLSLGPYGAMLSNGAEYTGDYRRTFLAESDPQREQQPSIEEMAAFHQRRIQAFVAQPSWKDVGVLAVETVPRADEALAFRIALENVVKSHAQRGIALEKKPVYISLAFPDDRRLPWPPLNTGNNNDETDGDVDMDEDDDEDAADQDGAVQEEMDWLVQIVSDTVVQGQESQWPISGIGINCTKPYLLPRLVERMSASLATLNRSASEGGCDLERKRSALGMQKPLLFLYPDGGLVYDPVRKVWLTPSTAGPYGGDNSAASWAANLMKLAKRITSSGDASFPDVWSGVFVGGCCKSGTDEIRALCQCRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQH3</accession>
    <name>W3VQH3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF938 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0585 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQH3"/>
    <dbReference type="HOGENOM" id="CLU_067698_2_0_1"/>
    <dbReference type="OrthoDB" id="10258744at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010342">
        <property type="entry name" value="DUF938"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974">
        <property type="entry name" value="UPF0585 PROTEIN CG18661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974:SF0">
        <property type="entry name" value="UPF0585 PROTEIN CG18661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06080">
        <property type="entry name" value="DUF938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27217" checksum="1DBC4C1158E33C11" modified="2014-03-19" version="1">MTDAAVSEADGKYRSSWSQSGSAERNSQPIAEALVSLLSAGPDTSPKPSVLEVASGFGHQIHAIASRYPDFQFHPSEADGYLRSQIDERVSELPNVSKAEALDLLDQNDWLTLAHNISGEASSSSDDGLFHGVIVCNLTHVAPWAVTESLFSHLDPRVGYVTQQGYRNLLSRQHGWIAIYGAFNENGTFTSPGNEAFDKEIRSRNPDFGLRDLQSEIIPLAHTHGYALAQRIRMPAGNLLLVFRLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQI1</accession>
    <name>W3VQI1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GLYK kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQI1"/>
    <dbReference type="HOGENOM" id="CLU_056986_1_0_1"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001691">
        <property type="entry name" value="Probable ATP-dependent kinase TDA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33754" checksum="06E672A308B69955" modified="2014-03-19" version="1">MSANGATRSAIRAVDVFGQHVVQQLQSFRARFSGGASVPPLFVAMQGPQGSGKTTVTRALIQYLNSSGLNVGILSTDDLYHTHENLHRVARENPTNPLLSGRGQPGTHDTELGAELLDRIYAINERVSQTVELPVFDKSLFNGEGDRAPVSDASPALHSPLDVFILEGWSMGFSPISAAEVERKRSASPTESPLGRYKVEALHQINENLKAYRQWYEHFSVFLQIQPTDLNNVYIWRTQQEHAMKAANGGRGMSDDGVKAFVDRYMPGYYLFLDTIRENEQWKGRSKTVTIDLDRTCVAVEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQL0</accession>
    <name>W3VQL0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQL0"/>
    <dbReference type="HOGENOM" id="CLU_524936_0_0_1"/>
    <dbReference type="OrthoDB" id="2552152at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="44436" checksum="6FD8A4A21DA82896" modified="2014-03-19" version="1">MGRGRRPNLALEPTRALQTQRAFRQRKAEHLASLEATVKELTDENARLRQLLQRDAVSPGHSRSPRLTTNPIPAHPAAVASGSRSSSSSTSASTPTSLPTATCESCAPILHANRQLAVAATHVDAHMAQLQHAVKSLRSVLVHHNIPVPAHLLEPPNDEAYRHSKRMRYEPGAHQDHASPAASGVHMTASYFAPGESWHDPAQRRSVPASHASPAWHTPSPGSILAAPTPPSAGYSPRHSGAFSPPATEARTRRTARQSSTGRLPPASPRYTQLPPLAPFVEREERSRAEALHAGARNPPSGSSPAYVGSPFRNAAPLHSPRVRSVASPRPPEPHLSEPPKAAPASEPNPCGSAGKPGCCSKLDAPPARPEPKDWLPAPLGISFDMRTTPTNDAKPNDQDCCFGLVKCDDQGRILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQQ8</accession>
    <name>W3VQQ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQQ8"/>
    <dbReference type="HOGENOM" id="CLU_294252_0_0_1"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="845"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="936"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="DUF427" evidence="7">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="791"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="969"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="986"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1026" mass="111358" checksum="BD56FC3C6058B681" modified="2014-03-19" version="1">MASKSQPTSGSKPPHRIVTTPSTSTLKITTSVNGHVHTLVYTDKAVELAETNYPLRFYFPPEAVQPPFSLVPSERDETFCPYKGFAQYFDVTLSGQPVERLTAAIWSYSAPFSTSDANDVRGLLCIAAPSPELMVTLNGSRLSESDVRAMSDSSLASSSSSVSSPSIPRHVMEQERRSRAAKRAQANLQPPAMKRSVSAGSSAPPESFPISRPLGGELEIDSTNPVVADMLYRLDDEAQEQQRDPDNSAAGADSQEAPVDDHLLWFKHEPWYRRPSEKWLRPFALVISMAGGMCMGPKLELLNMFVCETVLGDSYVGGGGIIAPQPPTNASALHSSLAQPLSHSAAHLARFQPWSLDASADAAADNDAVKQYMASLEAPNSTPNSTVIPVPRRPSKACFASPEVQSSLATLQLRMTLSMGILAALTTGFWSNLSSRIGRLPVLRISMAGIVFTDLVILTAALVPRSKLPFGYSFLVLGTTVEGLLGGYSAAIAVHQSYISDVTPSGTRAHIFAHFMGIVYLGLAVGPTLGGLIVKHTNNILAPFWFALAMHLLYVLGIFTFIPESTNKDFREKARKEYIESRAEIKRKADARKTAELQPLLNSRDWEGDHRPFNRRVWKRVKVAFMGSVLYAPLEPLSFLLPKKVVVADEDDEAAQASGAGTPRGLAPPEASASHISVSRVPPTTRYDYNLSFLSLTYFTETAVFGIMSFKMQYAQERFIWGSAELGMYLTFLSITRVLALTFILPVAIKFLHRPVKALRLPQDGPAVEEEQTLAPDSRRQSMLDDEGRLHRGTSGYGTMDDSRSTNEQGEEAEWDATKKSVEELWTLRAKHLRLIHDSKFDLKLAKISVTVNTLSYVLLVFSGTPETFFLSTAITALGGGGGAAMSSLALALLKSPADAGKLFGAWSITSAISGTVVGPILFAEVFRRTTKTFPPAIFIVGAGMYLVAFFLLCCVKVRKPISLPPLPARPHPAPSTGEQPAEDGAQTTGYRSSTFNKGFSLKTVKGKSASATQRASARPAIPAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQR6</accession>
    <name>W3VQR6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQR6"/>
    <dbReference type="HOGENOM" id="CLU_013817_0_1_1"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="483"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="74855" checksum="E5024283FEA3CA77" modified="2014-03-19" version="1">MVETHLPALSADREAHVQSLLQYPSSTPHLNRFGLSIRDPGGGRGRGVYATAPLAADTLIEVSPVLLFPPAEYAEYGSKTQLDGYTFVWKRTGGRAVMALALGLGSLFNHHPIAPNVKYVLDHATHSISYTTTRAVAEGEELTISYGAGRMWWEPPPSQEVTEREEQEKRQAQDPDHAAMEMGRIGLSDDEDEQEPSSVDKSKRVENGIEVRSAPGPSRPATGPAMHRITAGVDPVTVPLATRDAWIIDIPPTSASSAVKFLQKHPAELQNRDDGLHSTRHLRSFRTSTSVDTNGRKVARTHFLLCLRTAFPDRSRLVSWLRTEGGSVFGESPDPYIGQVPVIAAPTKERLTEWQAVWPCIVRTNAKELVPDNGGNPVLLVDRKGDEKMWHDTQRVQWACNRFKRCVALARHALKEAKDQSPEAKTKAIGSAVHVTHPFDTARHFQSASRAMTWEEREGCDWSQLTGPGAPIVGRLPPCGATTTWDSHKERIISTLGMTEAQWSVFNTTPSASVAVYTSPSPGVGTIEVDALDMRLALRNPLKHAVISAVSRVSTLRGIDRSNSSLAVANGADYLLTGLALFTIYEPCIYCCMALVHSRVSEVYFLLPSPGRGGCCGANLPPSSQCDRANDGGIYAIQEQKGLNHAFTVWRWMHPSLALPHEANAQSADALDDLATELHIGLLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQY7</accession>
    <name>W3VQY7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GCF C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQY7"/>
    <dbReference type="HOGENOM" id="CLU_014829_0_0_1"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="908" mass="97545" checksum="87CCE2FCE037627E" modified="2014-03-19" version="1">MEGGDPSSGSASFVKRRKPKGVATRVSSAYDEVDDASQAAGPSAPTTASGASRSSTPRQMLSRGGSDEEQEPDAGGVVFRPRARGARATPTAASTAKPVTRGVGNGETVEDENDDDDVPALAPRRSKVDGARRPARMSGVGMSARSSSSASTPKRSTPLRPTAFKDMPTHEQAEGSTSTPTSSLYTSKHLEELRTSTPTARSRAHSPAPAPPGPATFMDDPMAASSSRPGLAAGDDDALTRSKYAADFEHDAIPSESVIRAAKERRAKLRAAGASSGVSDDFISLAPFSRSSAVQAYDAMEVDDGPHPHSRLQREEDELGDGEDEFAEYTGASERIPIGAKAQEELQRRQRRQMEAAVRGDFDDDAPGAVADEMDEDEEEWERAQLRRTQPSAAAASREASPFRAAPIPDPAPVPSVGTCSARLQLTLRALDQSKGAADAVLASSLVELDGLAEAEKQNKLDVTAVEDKASWFDELDGFVASLARFAGEKKARVNEIESDAVALIARRTALLNRARAAWLQARWEEAFGTRPTKSLIPSIDDDEEKRESSLPDHLTGKAASVLPKLDELAAADQLSLDLAKREIIDRLNATFSDVQAPEYLDPLAPIDAGASDSDSPSGLAWLRRTRADWTALHPRSVVVRFEEWRRRYPDEYAQVWGGLSVGQIWEFYARLEMVAWDAFRTREHSGWTAGVGALVDFRWFTGASEYTERAMRHPRAPLGGDDEVLTSLTTNVLVPRLVAMLSAGGVSVWSLEEVEQLVGVVDIVQTVLDDTHARYISLAEAVLGVFASQIQRLQDSVGEIHGLTGNVMAAAHVLKEMLGLVRNAVMLARVIKPSSATDSPTALVGNRLVLLVEQLSLAVVHPIIGRLHESPTTQQLAAAMRQALIHEIPPTITAHNLGLTAFTASGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR56</accession>
    <name>W3VR56_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR56"/>
    <dbReference type="HOGENOM" id="CLU_031345_1_0_1"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="591" mass="60828" checksum="1F6F80DAA7AA9F87" modified="2014-03-19" version="1">MSSFKRRVNATSGSAPLPLPAGVKPSSFSSPVPLVSTGVPALDDLLSGGGLSSGADLLLLPASGTAAHSAAHTGASTSTPSATAETDHAARALAEPYLDLLLGYSVAQGIASSHANIIIGEDVAGFTSGLMARAGDLDDQFLAQLGPATAPAADAEAPSDSLDTVVDEDDAQTPSSKTPAEGDVTSQREREMKIAWRYHSMKQFNTTVNEPSTSAAGAGAEAQPFCQTFDLSKRIDPRLVQHAAAQGRLEVVDVADQLAGESSYEVALQRIAAVADRCRKQQLAAPTSAPPVLRIAVRSLGSPSWTTARGQTAHTETVRFLHRLRHLLRSLALTDTTPSSRTVAIPAIAVISISSFLLSGTSWGAPVNLAHRLVHSVDAAVSLSAFASSAALRRAFSAYTGAFKVLKTPAIGTLTNPSIRSSVLRGMGSGAASTGGLAGAGEGGAGGGENNLAFKVRRKRLVIETLHLDVEGGVSERRTKPPKSEAEPKRATPVPQSRTEDRTVAAKAEAQGAKGAQGAQPTGNAPKLKGLAALRQRGMAAAASAPPTGEYAVQVDTAPRSAHSHGRPGATQRAPPPLSKASQARPQDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRJ6</accession>
    <name>W3VRJ6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254555_0_0_1"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000041">
        <property type="entry name" value="Related to MNR2-Manganese resistance protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF90">
        <property type="entry name" value="CORA METAL ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1359"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1395"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1434" mass="156773" checksum="0C50B23E9E8E372E" modified="2014-03-19" version="1">MSSSAHHPHDGSAASTTDAQLNSPPPFPAQPQRHHSSPPPVDLDLDLNLNLDLDTPALPPAALMPPDVPPPPRRPANRQDALMDDALRSLPPAAERNTHRHKSPATVLSMFNTNTFAAASPTPPPPQQQHTQSFAYPPPTASSSRALQRTITSNTVRSARSVGSDSTSSSHRHRLNPIRTAFTKVANLATPMSPKHMPSSATMSPTLDRKRSSMAHATSVQKTKEARRAARREARRAERRLRRQRDAQLQLADDEHDPPHFSPRPAHAAQLGDEIVELPAEPPLDVPEANAPTATALAMASKVGRKPKRKLQFAPDQRRIRKVDLPDSFEAEDTYRNLDQYVADSRQRRRTQRGRRGRRGARRRGSRSQRGSRSSRASRSSARSSASGASSSSSSSSSSSSSSSSSSSSSSSSGSGHGITIARLRAFFGDGSSSSSSSDSDDSSSSSSSSSSSSSSSSSSKSSSTTSDGTRSRRSSSRRLSFSNIRSAKSRRATRSRVRGDQSEASDAPGSPISHRRAPLTPYFGPLSDFPLGKKAAERRQNKKARQAARRAKKREAQLIRQGRLPPKPSRSARAKAMRAKELAGGVTEYQLFTPMRLPMDLACTALPTLEPTPDPQSGTSVVLKKTMRTQSWEQVRNQLYVLRNHLRQIDSHGGDIGLDPQAAYPILHRHQRHAAKIKPERGSHHHHHRAKKATPKGHIPQAVPEAPEEDFDLLDGDLALPPPALDLPEGAMEADVTMDNDSGVRPGGSSSRKGSSPDQDTASYLHYDRHLPADQEEEARTGRHLSDMPLSPHYAAVFGSDFGRQPHPFLPEPSSSARQRSSGRGAGSDPALHPIDASRPPISHPQRDDNHSKSGASAASSEATDHGAWWLHVHCPTYRDMHEISKLFPMHPLTVEDVLQQDPREKVDVFDRLGYYFVVIRAIDERYFRYTSTAAKGSPGFPNFASTSSSTTVHGEAEGKADTSGAGGEGEGQSFEMRELGAQKAGDDGAGGESPPDGHRTRLAAPARLGKGRVEIVEGIGGKEGLEGVSVGANNLYLLVFSHGVVSFAFEDVSKHINRVAARLLEITRPVELTADWIAHDLYDSVVDAFFPLISFVQSEVVEVEELASEPVSTSRSRKTNNFAPKQRRQRALLGSNPEGRLISVEPVSPLSTGLEVEKRMPMLEVRRLKTVRAVRFLPVLRLGEGVLNRLPRVLVKQRQKVTISRLPEWEFKDTLEAEMRRTAAEIDEASNSVFDTQAAADQSIMLHRIADTRKIVTGLSRLLGPKNDAVKGLRKRLSDMQQLQRRAEGARRVGGNSRNLLARTEVSMYMSDVHDHIISMLHQLNSGEGRLSEIHHTYLAQITIENRRFRQGADAAILFLAGIGTTVFTIVFITSIFSVNVARPQNEQGTHHLGWFGGIVGTAAVVPFVIYAYVRVCWIKSKQRLANKRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS14</accession>
    <name>W3VS14_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS14"/>
    <dbReference type="HOGENOM" id="CLU_317823_0_0_1"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="437"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="917" mass="99213" checksum="D3D17CFDCE025563" modified="2014-03-19" version="1">MPASSPTNSISSKKRRTTRKTCAPCKAKARTCSASLPCQECVAAGEATSCHYRGGLRLNALKRPDDARVAGSSRGLKATRLIAPSPSPARFLTSPASVEASSRQLRVPDRPDNSSPANSVTGSAGSGQVPAGWEPLQQTADPTHLFLPSPLDTLARIAQEAALQKSQSIGSLASWSNNANPCERGYGSTNPSPTHLRTSDQVGKTANDDPGAREQPAPVVLPFFRYFGNTAIAPGPRCVEVEVRDEQTTLMNHHHVSIPETSQSEPSDTLRELRAPAAREATGNKASQEPFTGLFDDTNPSLPSRTILARLIRVFFQTMSCHLPFLSEERIMAELEQGQLEPLEANCIAALACRFGDDPGSRSQLFGARLETPKSRRHAASYAGATPSVARYVRAEPFAEKAKELIYPMFALPSLKVCQALVMITWIEWGSDRDSSAWLWSGLAIRMSQDMGLSYWDSLDSISDGETRRVHRLTFWAVYFLDRVISYGAGRRVTIARADIEIDPPTSAECHGCRREPARRGVSHPWPHLIRLLGLRGDISDQLNSRSASKPADWAGGGKEALHDFFRSLPMDVRFNVSNLRSHSLNDAAPVLVMMHCLFHSLVCVLHRPSLVQTKGDWTEDREFAEAFQSAASRFPAECASSARSITDMLSFSGLVDERTIVCNPYMDHAMFIGAIAMVDELRQVMHANGRRNRAVAGEAGASATGCDASDGVEARFAEETLREKIVMMREALETLSRFWGGIRWVCGWLDERSRALQPRAEAEASGSKATYQAAPAKVKADMMRFLARLRAAKRSAPLERVVQDAVSGSASAAKLASVPIAIGSPRSRLEGVGLSDPSQSVQSGEAGETCEGGDALRAATAPAGVVQLGASEPPFGDGWDSLEALLGEQGLVFDGICDFETAWDEMGDSSGMLNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS30</accession>
    <name>W3VS30_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS30"/>
    <dbReference type="HOGENOM" id="CLU_007741_0_0_1"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="899" mass="98223" checksum="B9404221B4819CA2" modified="2014-03-19" version="1">MPHDAAPSSSASRMPALATSAGPSSAASPSSPSTPSNHAAQPVKRRRYARRSCLNCRSKKARCELPDELVASSHDPLPVYKACHRCRALDIACVVWDGDRKRKPRLGPSSTSSSTAQSANHSPLLSVGANGPTDLLSNQHKDSRRGDPSDSQDAAASRMRDPYDDLVSNGSPPSRRHNRSDSFISLSRDDTYAQQPSASHTSLLAQSKALRAHQRTASSASSVDPANTRYDAALFSGPIEGSKCIVIDREIQILTNRFMHSPLVTLNRFITKIPSFSRLLRPDTDRSFDGNLSDLLTDENILELQPHIPLLRMWHPHIPDLTQLRSTYRESHQSLATSLLLATVCLVASKIAGRRHLAKHFAIHVDRLGLQALVAAPKHIHAAQAFELLLAHDPSLIGASFDSASIPSTQSAVFGESLHSSALSIAEAIGLDLVMSQSQHHHNAAAANNQANGAHSHTDDSSLRWQLQRFSLWCSLSLWRATFVFLNSTIRALDFSQLSRDAQLAIALVDQLKPPRTPSSHDDPTNETLFKAGILALAYRAIHVAEFNTRMAHIETFWHNRSVFSTADIRHEVHSRIKHNINADEELKKEKRRRLWSLANLPELRLLDRWIDLHIESNWTIMQQLYMRSVFPDCGPGDTLLDLARVILDDPGLFRFCSEASQATYLRAEGVLAGVAASPRFEAQRLEQTGLPLLLTCGFILHITISLMEALNYVQYGLSEVALREDMFALILARLAERLVAPKEAEHESLERLVSGLLVQMSRRLSDSEYLRVTRSAASEWRPDATQQPVSVDACSVGSVGSHGEAVRNDGAQPNAVNGGIASLAAIPVSWLPTSQAALPQTQLGHLGSAAASTDPLAASAASLLGTADAMSAENMAHIMDQILNWDAKPNAAVAQHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS34</accession>
    <name>W3VS34_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS34"/>
    <dbReference type="HOGENOM" id="CLU_1759601_0_0_1"/>
    <dbReference type="OrthoDB" id="10317106at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="148" mass="16821" checksum="32F813E4977D50E4" modified="2014-03-19" version="1">MPRQTPVARSKKPCPRCSFVITHIPQNLSWLFLVDLWSVADRSLRHFQIMRDVSKRDTPEGEWFILVKVKHAAARKAIESVLLEHKAVTRTVSHDESDDLIQRFTQDDQDLFSQFATDRAEVLGETSRAGAQRSLPAPTVDQEAVNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS40</accession>
    <name>W3VS40_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS40"/>
    <dbReference type="HOGENOM" id="CLU_005417_1_0_1"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="478"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="595"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1096" mass="115916" checksum="032699BE3AF45CC3" modified="2014-03-19" version="1">MPRSAPSSPTKKAAQPASLAAEKPSALPSAAMDVDAEPSNQDASTSQAATSGKNRSRKSKKSIFRSKDRSAAFSPFQTISEGRVSRLPVVFTRDADYFFAVSKTSVRIYSRTTGQVVSTLSSGPGSHFAAITAIMINPANPLQLLTASLDGCVKVWDFLDGILLSSFDLQLPISGMAAHESNPNTLYVLLKKFRHRDADTAPKNLSEILAVLESGAPFNSIIAHFSLDLASHAHAYTALPKFARGASIRPEVSRIGKTREAVSIGVSPNGEWLVVVGNDKVQVARTHNLASGFTRFISSHPGAQHRRDSMTCMAFHPTDPTRLVTGDASGRIRVWYCLQNNFMAPSKAEADDGMERHAPSTVLHWHAHAVSSLCFSPNGAQLLSGGEEGVLVVWHLGASGNAASKEFVPRLGAPLSAIAVANGLDGREQEYAVSLADGSITFVSSMSLKPTRSFTRIKIDASRYLPGASLSASTPVPLAVHPASRNIVLLAGHPSSLQFYDPTKDANTAELEVAPSNRVSRVEDEQIEPTRVERVVFSPFVSTKTAEAGEWMVTFDSRNLSDGEDDVEVIAESSLKFWRWNPINRRYVLNTRIDRPHNARRITSITFSPTDALVVTTATDGKVRTWHLASRKIKSGKNESYWACRSVFGYRQQLPTTTAFSADGSILAVGQVGSVTLWSPESNLMSMVISAPELANGVESLAFSGRYLGIAAGSAVLVWDLILSRQVSRKGLEAGKQASLLLPSTSSADFAEEADRPLFTLVSSTADASDAAGAEASATRQAKTIVETVSLVSDREMATSSAAASAHAASKAASGSGQRVIFRTSVAAVAPVPLPAGARAQAQDFVAVSTEMDLVTFSSSPSSSTAAGADATAESIRGISSVKKTLFDDLFGPSAFRDARDEAQDDHDQDEPMANADLVAGSVGSGVASLFSTAPHLLPPATLLFDAFLSKMLPPAIATPAAGAAPTTSVRLDATVDDADKKDADARKADAVASGERGISDVLLADTDELVELYKNQILTEDVTKTDAPVKVNGSLAVAAPSKKSSTPVKANGLSKSPLSKGFSAASQNGTPRTPAGSKQEALVQSPSVSSRKRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSE6</accession>
    <name>W3VSE6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidoreductase putative C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSE6"/>
    <dbReference type="HOGENOM" id="CLU_039338_0_0_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="1">
        <location>
            <begin position="170"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="402" mass="44120" checksum="3C4F5009237F0022" modified="2014-03-19" version="1">MSDRYNTVIIGAGEINFGSPEGPWSHTARLERIFKSASVKLHVLGLIDPNLARAAERIREKAGSSDDQVRSSWSKAEAWGTISEAASSLAADQGQVVDLVILGCPPHFRGTLQSGKRADLEMLEHFPQARAYLVEKPVAAVNPFSTADCDEVASRFAASSGATSVGYMLRYNKAILRVREMLRANSLTPTCINARYFMAYEYARKLDWWNKSRSCGPVVEQATHFIDLIRFLAGDDNEALLETVKATTVQHFEPVGALSKLGFDESEIPQAERVPRVTSAFWKHQKGTIGSLTHGIALHGGTYDTEIEVLADGWIFRVRNAYDATTTLAIRSPGKAEEEILKIEDDPFLTEFECLVGCSLDGVESLISSEGVPSSPLSTFADALKTYKLSWRIRLAAEEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSW3</accession>
    <name>W3VSW3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSW3"/>
    <dbReference type="HOGENOM" id="CLU_033465_6_2_1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="314" mass="33815" checksum="982AECEFA4137F99" modified="2014-03-19" version="1">MSSLPRNPNPNPPDGETSVNIYGYTPWLALCIFSAAFFGVALFLHAGYAVSAARRREKVPAASYEDQMGTKRIDSEPEGTINAGVTTFEVPFCVGCALEVVGYAFRTASSRNPFVLTSFILNYFMIVVAPVFFSASQYYCLSLLLQRHPSYTSLVPLSGKAIVATFVTADAVTIVMQIAGAALVGVAESDRASGKVPPLTPAQANDILRAGLAVQVFSITIFLLLLALLFCKVTRRGSINTASPDAWRRRALLAVLALSTVFIYLRTVFRLAEAASGVTSGITLNQALFVALETVPVFVAVLLWTVLPLHVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT05</accession>
    <name>W3VT05_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT05"/>
    <dbReference type="HOGENOM" id="CLU_109463_0_1_1"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="22642" checksum="49A642F1B246FDD6" modified="2014-03-19" version="1">MVDSSAAIRRGHPISFLLFTFVAFIVAVIASTLVADYNSNGNAPTKGIENATRFLLFAGWWGFLIGAVYVSVLERAEILPASAFAAIRRCAHSTSHDFDTNQRSPSDAPPTKQTGLFLASVGGVITSIAGHGVALFLTWIFWLAGAAALTDRTGGSFNCADKGYPFPYCNSTKALMAFAWIGWIILTLMFAVVVFFGARAFSGGRSVKESLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT94</accession>
    <name>W3VT94_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT94"/>
    <dbReference type="HOGENOM" id="CLU_046496_1_0_1"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="116"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="366" mass="39947" checksum="0BEC19FA50B149F2" modified="2014-03-19" version="1">MAANVPDPTRILSVQSHVVSGYVGNRSATFPLQLLGWDVDVANTVQFSNHTGYGRWGGLRFDAQHLQDLFDGLEKNGLLRYSRMLTGYMPSAAVVGTVLQLVKKLRSRKADDEGGLVYLLDPVMGDMGRGMYVAPEVLPIYKQMLPYATIVTPNQFEAQALTGIDIIDLASMRSVIHALHTQHKVPHVIVTSVELPDADLAAIGAHRQLPDGRPAMLQVGSSLDIHTNQDGERSASTLTPDELSIWCIQFPEVQGYFSGVGDMFAALTLGRFHPQGQADGAQDAKARPLTPIARASEMAIASLQGVLTNTCRVIDQIEAALPAQASPDADAAQTKVDTMRRRELRVVQSRAEIENPTIVYRARWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTA0</accession>
    <name>W3VTA0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_02369</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTA0"/>
    <dbReference type="HOGENOM" id="CLU_013513_5_1_1"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="66"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS64032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="646" mass="71348" checksum="A1BF87A1D910C4C9" modified="2014-03-19" version="1">MTLLGLGRSQARSSAARLASQKPLSLAANLKHASAPAMSRYSSSSTNSGGIGNGPMYEGQSAMPHLPVPALEQTLKKYLRSTVPHQTKESLAKTEQAVQSALSGDDAKLVQTLQQRLEHRATNEGRESWLSEWWNDAAYMAYRDPVVPYVSYFYSHKDDKTRRTGPKRAAGLLKAFLAFRRLLETEQLAPEKGKAGPLCMRSYKWMFNANRIPEMPSDTAVKYDWKANNHLVVLRNGHFYEFDLVHDGQELSEAEIESQLQTILADSASSKPAAQPVGALSSNNRDKWTESRKALAALPGNQQALERIDSSVIVVCLDETAPHSIESTAWGLWCGDGKNRFYDKQQIIAFANGKSGFMGEHSMMDGTPTLRLNDFALQALEAGKIDLGSSKRTDLPAPKQITFNTDKNVEAKIAESIGDFESLMGRHDLAVLDFQGYGKGAIKKFKCSPDAWVQMVIQLAYFKMYGKPCPTYESAQTRKFKWGRTETIRSASVESKAFCEAMESHSATDAERFEKFQAAVKQHLGYASAAADGQGVDRHLFGLKKLLKEGEKVPAIYEDAAYAASSTWKLSTSQISSEVFSCWGFGEVTPEGFGCAYAIKENSLTFTLTSLKLGASDLKHYINEAAVELRDLHLRLQQNDAPKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTF6</accession>
    <name>W3VTF6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTF6"/>
    <dbReference type="HOGENOM" id="CLU_307571_0_0_1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="524"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="961" mass="99286" checksum="C806D38A0ABB897F" modified="2014-03-19" version="1">MAPSSAAVLPPLAERPRHPLSHQKASLSHNDRKLTAAPQRPGSASETSQSSPQSIHIDEPFRTPVTSSSSRPSVSPTTPKLPPGSSSSDDKHKPELSNTQQRKTPPSTKTTTKMFDGGFSPSIDVADDAVGGSGKADRILGPDGKLYTQGEAARLGLIIRTACEACRNRKLKCSGTLPEDGGCGRCKSDNVECVYSARAPIGRPKKRKVEEGQDAVSVSPSRSALSSQDGGSSTQKTKLKGKGKERASNNLIARVRSEDSSFSTASPLGGGSLYQPDSFFMPGTPEHSTASHDNSPAVTTPNMFGIYPSSLSTPSIPGAGFEDSRLPSTPVIWSQQHSMAYAVTPSDVMTPPVPISPATSQPRPSPAQTALAAKMPSLDDLSVAAFLQSLDTLEISSEELMQQQLQRGNADAATGSAGRASDASFAQGAPSEATNADARPISTSSVEAWALSSAILQPGLSFAVPADFSWWDLGLNGADPGSGGPSVSGTPSAELPAFSFQAGQIAQAGSTPSIAGMVGGQSSKGALLSSAKPRKRRPTFGSDQPWPRGALAGMGQGQIQQAVAATETGLGWSTLPGLEAAARSSASPDGAQVNGSSTKSCCSSKPNSGTSDSPVDEHVRPKGEGVDSVVKSPCCSSKPTRQATPPASVPTSAPSCCSGKFAPQNEVADTDSCCSSNGPAATSKSGAEVEIEMGPLSTSAAVTGKVKESLNVECRRHAETHAHHPRKVHCVPNPSGKGCTCLCDMSVALLSVRQVLRETDPARTDGRGTATSAARSASFATDTIQLTLTASQAITAQCACSADCPTCQSDPSTEISASLLVSTALQIYARAVRVLREGFAASTAGKTESAEVAAAGGFFGGLDVTIGTYKPSAANAKKIALFAIKLELKDLRRALGKISRMAQSWGTTADVPKPTDDAAQLENSGDDKAQCMNPIDQLVILKLYRQLTELLKTVEGLEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTG2</accession>
    <name>W3VTG2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01332</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002477_1_0_1"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="516"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="752"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="822"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="905"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1209"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1367"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1796" mass="193600" checksum="7D271F371255448B" modified="2014-03-19" version="1">MDLYSTSFTIPRSVGASSFVSDPAASAPGPSNSAPGFGNDVLRNATNLGSRAGPAASPAQEAPASSLPGRFTSMRSRFPPSVKAFMPSAFGGKRTSERIVEAVGAEKAEADASAADAAAAANKSSSTTAAKDVETSAPLAPIGERGNARPFKLAHQGIASPDDVAASQHRDSRSTVGTRSSFDLSSNASFVADSTAPSSAVGGNPSSTTHSASNSISANQHDRSMAHSQSSKDLQEAIQKLSSDVMANHQCLVSFAPVPQPDESRLPSTPLTHPFQRQSSFSSLQSLDQLPFPNPNAASSSGYPYQQYHPQPIGTPDSHSSAFFTGRSTGEALGAGFPGLNSSSLSLSSLNPQSATGSHIAQEVGLSSAQSLRSPQSAAMAASRASLSGVSKPPQYNFHLSGGFQHVMNARGAILRENPFKLTASIKVPRADVFDIAPGSSPPGKESVKADIRRKLDEVQTATGATLTVKSNDVRGADLGYGLETERMIEVLVSGPFESVELARVKALVIFDEITGLRSEICEIDYKLHNIIGGRKRCVVQKIEEETGTNIYLPSSFLGTFGSSAAGRAPGLAAQQNQIHITGEFFGVQRARDMLFQVSMHKSKGIISRDAAILPRKLDWMLTERLEELRSIMMDNGTYVAFPLLGSQTSVISVFGDHRVNIERTIRSIMQLACQFYVASLWLLPVGFDVYMPSQANLNPTQVAPVLKHVSSASGAEVVFKSNCFEIHGLESEVRTAVSALLDLDLIKSFNFEVRFQIELANEHREFISGKKNGKVNKVMKQCGVRIKFETLNDYNFLIDVSGNDRNGVLQGLGLLQEELPAEISFHVPEAYHKRIIGVGGKNIQRIMKKFGVYVKFSNAEEFAALGGYLDNEDNVIARTPAKNAANLENLKLSVMELVSPKDKDYISETVTISRRYHRTLLGEKAIFIHDIESKTSSSVRFPARESASDLLTIFGPESQIHIAAQMLLDHVPFEAEFRAPNSPELAQAIQLPEFATLTEQLKRDLSIAVSPVIEQRRPGGEAVFKLRLNRSNTDFLPTAKDAIEDFLINHNANIYAAPSRTRSDSFASAFPHFANKLISTAAAAESNESFQNSAAAAAAAAAAAEQARVNERRLRAAASTPDIKALFDSPAQHLHGGPGFPTTNGVSSATAANSPMIPSSLYASPYGNGRGFGSDVWGMPTRGFAPSATSSATPSLIGLPAPAMGTASAGLPSPAGPGPIGGAVPSSSGGIQFPSQPLHHQGANPRLSDELHMNRGVEGMSMEERVKALRKPRSFAHRAQSLDIGAMAAQQASQHASGSMSVGPSTPYGLGPIGTGAPTHFPGHVGAPSGFAAGPAHHLYQSAQQQPSPHDAQAGFGLNNHAAQPHHLHAASASISRLPPGRNAPNPDASTMDEVSRVLAQLAFDRAGARMQTMGAEQGGLGIMEDDRETVRLWRVNKTIHELVRDRGYQVADDEINIDLESFKAEYAPTGGSVDRTKLNFFTEHSAHENQRLFVFYSMERNVGVKTMRQFISIMEERDIQRGIIIWPDKMTSAARKVIDAMRGTFHLEDFEEAYLLVNITHHHLVPRHEPLYPDEKKELLQRYRLKETQLPRIQQADPVAKYFGLQRGQVVKITRPSETSGRYCSYRICIMASAAAAPTAGSHYPPAVSSYYFGPPPSSAAFGQGVTGNPTLHVPKEIVRIERDYSSGELPQFHPSFPLEIEGRISPTTFSELVNDLNALLIEAHNPRRVWIDNTLAIATLYLSTLVHTSHYKKTMAKVDELVARTNAQVLEKAGLRMVHPAKTAFLFIELEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTT5</accession>
    <name>W3VTT5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTT5"/>
    <dbReference type="HOGENOM" id="CLU_297737_0_0_1"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="50"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="662"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="242"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="761"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="981"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="985"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1039" mass="114060" checksum="DC044C58A8C01A37" modified="2014-03-19" version="1">MAAAAAPSSQSDAPAAMDFSYDDETQPGESQFPTLTPLSHDLELLSPIHAPNFSVDDFLLSRTKASDLNFILSDLRSYNEKLKDELYSIINEDYKDFVSLGSSLKAEAHRIARLGFTAPARSDASADHVPPQGLMAPVRDTLLASRSMLKSVQDDIASCMKRKEEAASHKARLELMLQLQDSIVRLEELLLIQQPHPQRNRRKSSLSARRPSVISIASQPERRGSLASVAADSDDALSDYAMSSEYDEDSDSDDRTQLSDALSNRPRRKALRRSSVAKDVVHDEPTSPSATRIRSDTVNGGASSLLGLPQRIARTSAEYSRLRFLHRRIDEEGLSQFTDVLQDRIDHVCSVLRQDLRALLGVLLAPGSLLVHGQSSARTPGSPELRRSSRPSPGSARRASFLGTSTLGKPATIHEQGASELDSWSQVAEPTDESAGAESAYWQARLDEQRSWLEMALATLNTLTLVRAKDGQDGAGNVARRRNEAEEAVRDLFVSKWAARTIAENPSSNVETEETGGLPSTALAMFQEHSQRAQSALLPTIESDRLSTVYNAVLTFVGTTAWQVVDAAREVSLQSMHSTETPASAAREDAQCDVFVHVLWDEISARLLDDLGTVIFFVGQTDSFYAHYTVTRAFLDKLSALAPTETSRAALHAHPGWTAFRRRWQLPVYFQMRFREVVTQLEVGLADGRARVAEGEMMQATRATLDAVARVWSDGMHIHELSAREWRVTLQILSRYKTWVEEWSPVEAGISNRPLDALRAGAATGSADGSRSSMDRAGSVEISRSATPQPAPDVSTQQHEDEQLALGAALVGDCLLLRTRIHALLDETILARISSCIEADSDGLEELRSDLVKVLDRETFDFIAGLVSGVGRLAFGTISPRVAAPLRLLRSFSTPAYRANSSSANAGVEVVQQLFAPLEAFLKLEAVRAIPDDIKRDWTEPILTYAFRSYTTTVETITKNQQSLIRLKKSQAPSSGLLGMFRGSKAADDNNDDERAQANKSALSTFQAKLQGLDLALDSESFAPWTRLKTFLESDLDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTV6</accession>
    <name>W3VTV6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTV6"/>
    <dbReference type="HOGENOM" id="CLU_1074099_0_0_1"/>
    <dbReference type="OrthoDB" id="2555777at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="259" mass="29393" checksum="2A522AA3B46571E9" modified="2014-03-19" version="1">MAGHRHRSHRLLRRHARQPDSLLVKHHTLFRSLSRYADENATTTVSTSAKAASRAHAAALQSNRITRLKQRYPVADIWTYSWPRPPTDHPTSSLDPKTQVDEAVARIVADCFEREYERFRTPEYCKEHRISKEHRDQIVIDANDVETCAAAAQALVHTAITRFTTAANRGLVGKRPQKIAEAASTSDAADEARDAEKDAAELDQEMGRPQHTLGWQELLDFFQSTVGNSAAAQWRNWHLIEAIARTRLRCKELFPHESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU11</accession>
    <name>W3VU11_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU11"/>
    <dbReference type="HOGENOM" id="CLU_043216_1_1_1"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.900:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="174"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="254" mass="28788" checksum="BC023B968CF617CE" modified="2014-03-19" version="1">MPVFQPANQIKLTNVSIVRLRKGGKRFEIACYKNKVREWRTGVETDLDEVVQIENVFLNVSKGQVAPSDDLQKAFGTTDTAKILQEILKKGELQVGEKERQHELANTWRDIATQVAEKCVDPGSQRPYTVGMIEKAMHDVHYSVKTGRSAKQQALDVIRLLQEKKTMPIERARMRIRITMPAKDGKKLKPKILALTHAIDDEDWGEDWELVAFIDPGALKAINELVEAEIKGRANVETLNFTTIREGDGDERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUC2</accession>
    <name>W3VUC2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUC2"/>
    <dbReference type="HOGENOM" id="CLU_140506_0_0_1"/>
    <dbReference type="OrthoDB" id="3359339at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="159" mass="17193" checksum="A5247CFA0D3032EF" modified="2014-03-19" version="1">MSDAYAGKSDQQIINEQFQDLDRKSDNRLKDSFNPKTTVTSEESGVNESGLEKFPGASVSVGRTGQTGGGTNPQNIPPEEGGDGRSQRTGESSIRFEGTGGPEDKKYEALRDNPGGFDAKPRGIDESRQAQLNEPVPRTEPQRLEADQEATARSHVINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUN9</accession>
    <name>W3VUN9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUN9"/>
    <dbReference type="HOGENOM" id="CLU_028208_1_1_1"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000680">
        <property type="entry name" value="pachytene checkpoint protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="253"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="520" mass="56399" checksum="275344A82114B626" modified="2014-03-19" version="1">MVARRARRAESFVASDAQHSGRDAIADAIGVASPDRQHARQQTRKSLEDIGTTIAAKGGDDKTRILDTMAASAMQTESKALPRLPGSTSVPSGSVPVHVEVRLRPSSTASDETMRSEIEAFLTAHCTMLEAESEVASWSDSAFLSANVDRIRIAEVGARAATRSIPIPQARLEIHIYQPSSSDIVDEFSAADPGSDEGDETTAASVAELPNRSLDGVWDSLVYEDDIKAKLLNYIYTTLLFSDASVDFNLVSWNRVVLLHGPPGTGKTSLCKALAQKLAIRLAHRYSHGKLVEINSHSLFSKWFSESGKLVQRLFSMITEMVDDEDAFVVVLIDEVESLTAARSAAASGSEPTDAIRVVNALLTQLDKLKHRKNVLIMTTSNMSESIDNAFIDRADIKQYVGLPPAQAIYWILESCMRELMRVGLVAPTELPPFAQAERAQRHGDLEPGSPALQLLELANSCKGMSGRSLRRLPVLAHAHHIGMAQAPIECSVWLQAMALAVNDFDAGLDDQDGASETCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUP9</accession>
    <name>W3VUP9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00996</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUP9"/>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="609" mass="68067" checksum="4E1CC0ACC82AC092" modified="2014-03-19" version="1">MSKVPEKQATAPALSRLSSSAAVPTRRSGKKVIIIGAGAGGTALAARLGRRGHDVTVLEKNDFGGGRCSLIQHDGHRWDQGPSLYLMPEIFEACFKDLGEDIRSHIRLHQCNPAYRIHFADGEKMMLSSNLSQMGETLNFFEKRAGNKEDPLTNFLAFLKEAGENYEESITHVLTKDWSAWWAFFRPELFPMLWKTKGLRIYATLYDRTTKYFKSRHVRRALTFSAMYMGMSPFDAPATYSLLQYAEYAKGIWYPIGGFYKVVEAMENIARDKFGVDFRYSTNVKRIVVDERKGTAKGVELESGEVLEADVVVSNADLVWTYNELLPPSSYAKKLRSKDQTCSSISFYWSLNSVVEELGGHNIFLADAYQESFDEIFRDGDTPTEPSFYVNVPSRLDPSAAPPGKDTLVILVPCGPISIPEKPCTDPSKGARSREQFQKTKERARRQVIETLKKRLNRPDFEQLIDHEIVNDPFDWRDKFNLFRGSILGLSHTIPQVLWFRPSIQHASFSNLFFVGASTQPGTGVPVVVAGSGVVAERVNAFLEGRETGWLSWEAIRGSIFLAIIAMFGVMFAGFAAGFILLGLVIAVSVHLLGIADVPGLVRSRVIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUT1</accession>
    <name>W3VUT1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dna-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUT1"/>
    <dbReference type="HOGENOM" id="CLU_047594_0_0_1"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="6">
        <location>
            <begin position="266"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="347" mass="36928" checksum="0505B6CFB4902668" modified="2014-03-19" version="1">MGDRDMLLDMGFAPERVDWALYATKNAGLQPALDHLEAKQDSPVPTDYKSASAAALTSSGAGGHNYDEEDEAALADLVSKKGQQAADDAVNNVGEAKSIKCSDCGKTFKSPAFAQFHAEKSGHTSFEESTEEIKPLTEEEKKAKLEELRAKLAARRAAQSKIDAEESRVNEKIRRKAGQDLTEVKEEMKRKEQLKEAERKRKEKADDAAFKAKIKAQIEADKRERAAKAAADKAAREGKPAPTAAAPAGPSAAALAASAGPQASTSAANDARLRVRAPGGMWMGTLSADATLADVADKIRAEGKDGGSAQLKFSTTFPRKFFDASDATKTLRELGLVPSAALEASPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV74</accession>
    <name>W3VV74_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose/galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV74"/>
    <dbReference type="HOGENOM" id="CLU_028452_3_0_1"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17394">
        <property type="entry name" value="MFS_FucP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="69983" checksum="63F0ACC200162E46" modified="2014-03-19" version="1">MGPRRTPTASTGDDGEGLRWPSLPSTDEYRASSVETGSAHACVWGKLCKEQGSGWEPGPISRRCGVVRMTAALISATSTTDRRGASGDTWVVGAKFRRQIPLICATDPTADLQPTRLGPHPDSANNGVPALASLQRHRRMATAKALWGPALPDLSASCLCPPLRCTIDSYQATDRPSGAVPHPRAMGRFNKNNGPAADRAVTADTLTKSQLYFSFALVSSLFFVWGLSYGLLDSLNKTFQDSLHLTKAQSTGLQACYFGAYLINGPISGPLARKYGYPFSIHGGLGLFSLGAIMFWPCAVYYSYPGFLVCTFVTASGLAWLEMAANSYITVLGGPDMAAFRLVFAQSWNGVASVLGPIIAGRTFLKTGHSHTLNHLQWVYLGISLFGCVINFLFFIAKLPEVKQEVDAAIEAKPVSIWTQKHLIYGAIAEWFYVAVQVSIASLTINYYVEQPGLNITVSKAADLFSVTLAVFTIGRFIGVPILAKVDSALMLCICGIGCMIMTILTAVVPGNGGIACLMLIFFFESVCYPIIFTLATSNLGANQKLGSALVAAGVSGGAWGPSVQAVVADATSTHRSFFVPIGGFVVVSAYGLYMHLRGCKQQGYWSWRKLDKQTAMAVTAARRSDSDVEQDGSEKDVKVSTPTYASVPYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV82</accession>
    <name>W3VV82_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV82"/>
    <dbReference type="HOGENOM" id="CLU_062853_3_0_1"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="216" mass="24555" checksum="C63EEBD0A5869005" modified="2014-03-19" version="1">MSKIQVSSVRNTLKELIQASEDKRRNFNETVELQIGLKNYDPQRDKRFSGTVKLPHVPRPRMSMCILADAADVDRAKLINLEFMTVEDLKKLNKNKKLVKKLAKKYDAFLASEALIKQIPRLLGPGLSKAGKFPTPVSHNEDLEKKVTEVKSTIKFQLKKVLCLGVAVGHVQMTDDQLLANVMLAINFLISLLKKQWQNIKSLHVKSTMGKVYRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWK4</accession>
    <name>W3VWK4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00212</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWK4"/>
    <dbReference type="HOGENOM" id="CLU_038194_3_0_1"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11369">
        <property type="entry name" value="RNase_PH_RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000017">
        <property type="entry name" value="Exosome complex component Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033196">
        <property type="entry name" value="Rrp43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="54"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS65151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="318" mass="33338" checksum="1FC107B8AD5F9F5D" modified="2014-03-19" version="1">MSAAVQSSAASTSSTGNADIDLAATTFKRLHPVAYLSRFLDSSAREDGRSLAAFRDATLSLGSISTADGSSFVRIGNTSCIAAVKAEIASPQLSRSRQGYLIPNVELPAVCSSKFKAGAPGPEAQVLTSRLLALLNSSNVLDRDQLCIQEGQAVWCLYLDISFICFDGNDLDAAALATVAALSNTTLPNATYDPDSEVVRCSSSPADRVALQMGSIPFASSFAIFENKHLLSDPTAFEAALASSHVTIALSLDPQASTQSKAEPIVTYIHQSGRLATTTSDPPSHATDQQNLQTCIDRAHARATVLAALLRQAQSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWN8</accession>
    <name>W3VWN8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWN8"/>
    <dbReference type="HOGENOM" id="CLU_081023_1_0_1"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000145">
        <property type="entry name" value="ATG16-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="4">
        <location>
            <begin position="42"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="124"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="284" mass="31549" checksum="FC2AB424A3CE6DC6" modified="2014-03-19" version="1">MLPTNVHAPARVRAPAQPTITSASSAAMTTHGSTGMQWHQAIFLRLQERDVVEKQHDAMFQQYRKLAEQTRMLKQRNRALLNAAAVAPSPSSASASSPAGATSGAASPSPSVTPAATSVQLAYITSLEQQLASLRDEVATLYKTQGQNAQRLLLMNESHREKEDEARRQSELLAKLQIDHEKLRRQADDLTHAVGEKDRGIQILQDELATLSLELSQIEARNQDLKKDNASLLQRWLDRMNQEADRMNEGTIWLEEVRKRRESSTNAEGSPKPSDPKPPQPKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWU0</accession>
    <name>W3VWU0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hook family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWU0"/>
    <dbReference type="HOGENOM" id="CLU_017588_0_0_1"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="207"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="520"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="606"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="907" mass="100662" checksum="E95BFD4EB689FACE" modified="2014-03-19" version="1">MAEPSEPSASSTSSTAQAPRDAEIDAFVAWAQAVLADIPHADRNVSAPADLADGVALFQILADIDPDLFRNPHAGDTKDNWVLTIGTLKRLFKLMLQFYSQSLSCAPSPLPSPDLNAIARSADPEELAKLCLLAIGIAVQSEKNEAHIAAIQTLDHSHQTQLMVSIERIMSLIKQAQDEELAASAADDSTASSRAAAVDPDTHGRSFAELASELDTLRAEKDDIEKTYLVLLETHRSVTSEFQDLKAERDELTAKHQEYKKRVEEERNEQADVLLHQQIEKLKAELRRSEDALAELESDNEKLIQAAQDSKRKIDELQKTADEAVKLRDQIEEYKHAADRLQKAENAIEKYKKKLEEGADIRRQLKLLEDQNAELVDRNAKIEDEYKRVSAFKPLMDSYKTQIAELESKTSTLQRDLATSKYEQNQILSRLKASEDQRATEKEEMELYQERIKELELGGDAAGVRRKKLVSRASNVSANGVEGLVAADATRADTDSLDLDDDDELDRSGELEDALSGTTMTDLKIKVRKLARELEAAQTNKADQSRLIVLENLLEDAQRMKARYEADYLREHRDKMVLQSQLEAIRSGKSDLGDGTEAAYALRLRLNEVVEELDAAKRRLSELEVQNEQTLRELTVAKSDLALVNKDQVDILHSLRASMEADKDELEAHVKKLKAELGSMGEQNRMYMAQVNSLLMEKVDLQAEGIGQRDEALKRERALGDLRTRLQGKGLPKEVEELVASLQTEALNSTRDLKALQERFSKAKTFIKQQDRMIKEKDRSIAAAAAAGSLMGGAGGGEGGALRGEMGNEALELEARRLREQVRNLEREQTLMMSAFQDLGRRYMVELESGRNPSGGGAAGARSGSASYAAGGVRALSGLTGLNAPGRSWLANQRRLVNPTLQLANRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWV4</accession>
    <name>W3VWV4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWV4"/>
    <dbReference type="HOGENOM" id="CLU_669019_0_0_1"/>
    <dbReference type="OrthoDB" id="2556452at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS65297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="44112" checksum="556E91B5B7A1D92A" modified="2014-03-19" version="1">MSCFPPSFPIRSTINAPFVARPYPSGISSSSYLPLPSLSRVSLTFDPMSSLDAVQAHSNMQLLHEYMGFASPISLSRRSRIQRACIACRRRYVSDPATSSCSLASPQLTQLLFQHIRKIKCNGNLDGCAHCAEKDQKCFYEPVPADEKLKARSYKRQLIQRRQQTRVYYDRSHLPDPRMFAAAYGMPPAFMHGMAPHPTGFYTCQPALSSQAQMPGSMLASPISPPPTLSPMEQDVNSYLAVVASPESSMQLQSITGTSSFTHPIPAPLIMEPLSTPALSSSLSSPTLSVSSSSSSLLTPMSETFSELSTPLSATFPTSSIDPCASGQAHFHDFVGGLELYNVPCMANGFAANVPALPMEDLVMVDTTAPSAASSAYSSTEQFLAPLPASFGYISSQDSDATVSALAGAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD38</accession>
    <name>W3VD38_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD38"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_2_1"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000201">
        <property type="entry name" value="Salicylate hydroxylase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="450" mass="49987" checksum="ADB3AE488353FA9F" modified="2014-03-19" version="1">MSESSTFKQLNVAILGGGIGGFSAAIALRRAGHKCTVYERRGFDVEVGASISCAANGTQWLHDWGVDVQSGRPVILMELTMRDWESGEILNQYHLHDYEKTWGNVYNMFHRQDMHKMLLDTAVSPEGKGIPVEIVMDHIAENVDPDTDIITFRNGNKVHADLIIGSDGIRSKARVAIGVTPDIKSAPQTCYRCNVTKEEVERLGLTWAADPAIQFWGGYPKEGLNQYYKIVMSPCAGGDVVSFYCFMPTELTKHQSEGFVFEEVPPEEILAGAYSKLDPLCVKLIKNSVERKPWRLYVHQPYSHWYKKQTCILGDAAHPMMPHQSQGACQAIEDAAALGVIFSQEYNFTNNIEAGLKLYQDIRKPRATRVQQASTRALENLNERIGFSSLNAHDAALAASENKLTVNEMNTYDMKKHIRETVYPNLKSTPSVSTPIANISATSTPIAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD86</accession>
    <name>W3VD86_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_06428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD86"/>
    <dbReference type="HOGENOM" id="CLU_464591_0_0_1"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="377"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="197"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS59509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="589" mass="64569" checksum="277666EE61EBBD83" modified="2014-03-19" version="1">MRAIAQLVHASFRNVERAADWLTGAAGPVFIAICLTLVIGGIWTFFSTMFLELAPLPPELANLLHTYSPAHIALGLVPTLFDSAVKDPLATLRFFVSLMACLYIVYSIGWHYYMACTVSPGTVCDGLGDAVPERRSGPGSSIWWARYRARAARASGPKLAHLDSTHPELVTHGPPEPAAPVRVSSVADLRKLNKALDGLDTNRARSASVTASRSSSERPPPVVGASLSSSHRSSSSSEAGTPRIPRNDLPLSIHDVNPMVASPAILADVEPSSNPLFPPLTKHGLDADADTDAEEVDQDDEDVFPLAGMCRKCTTIPLVRALAVLPPELRKVEKQLRTAPPSQTFTSKLAPEDVDEGEAEVRAWLGDAAAEKLVAPPKPERAHHCRTCKTCTLKFDHHCPWLNQCVGLGNERYFVLFMAWLSTGCGVVLFSGWNVMRSSLSWSANWPYPYTPRVLVMLLFVLALVMGAALGVMAAWQLILVARGETSVESQDNTHYRELASKRGVEFINVYDVGWRRNLQLFFNIGPDSPYVWYTVLLPVRVPPYSDGWHFAKRRGLGGKHAGIDLQEHLTDEEFEDDHYQPQPPATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDR4</accession>
    <name>W3VDR4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDR4"/>
    <dbReference type="HOGENOM" id="CLU_2134609_0_0_1"/>
    <dbReference type="OrthoDB" id="10547096at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="113" mass="12321" checksum="EF0217B232181B1D" modified="2014-03-19" version="1">MKFSFRRHGTPRAQLEMAAEPGYRVCLGASDKDATSSRGRAGLRDIAARLHCRQPDEPETQPGPSLSTPRRGLSLPRRCPVEWQTGSLLVGFTEDLPVTGEQRSDSVSILACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEC1</accession>
    <name>W3VEC1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEC1"/>
    <dbReference type="HOGENOM" id="CLU_2264863_0_0_1"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832894" evidence="1">
        <location>
            <begin position="25"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="103" mass="10992" checksum="5CB5CA82C26988FF" modified="2014-03-19" version="1">MARPSTFFSPIVLVALLLLGTVRAQFFQQFFGGNAGGSMFGQREQEPPPIRCPYKDTNSMAKDQAKRAGGSFDGVNAELDLGGGVCISADSCEEANRFLQGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEV8</accession>
    <name>W3VEV8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEV8"/>
    <dbReference type="HOGENOM" id="CLU_010913_4_0_1"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="62"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="537" mass="58101" checksum="E34A864D6AC5E635" modified="2014-03-19" version="1">MVVALLKAIATCASTDGLSLCDAREYHRAKSAFVSANPSYSDSTLSALRKREFARLDATSSVYLDYTGAALYPASLVREHGRWLTSSVAGNPHSTSPASLHSSAAADEARAALLAFFDADPAEYDVVWTSNATAGLRIVGETYDFANKTMLIPRDAHNSLNSLARKAQQGGGRFEFIEFDSPSGEAISAPAYRRALDTASTSSEKGRGLVFLTGQSNITGAKLDLSLVQYAQQRGWDVGLDAAALAPSTRLSLRQLPVDFMVVSLYKIVGWPTGLGALILRKSQYANLTQKSTFFGGNIVGITMDTFDFTLVDGPERFEDGTANFAAMAAVRPGLEFAARWMPHYTARNRILMAWLIEQLEAIHHPGRCDEKTDSPRSSSTFSHKHSATGGAKLVRTGGPKDLDARGSTFPLVLTSAEGDALNYRFVIWAAARQRISLRGGPCMCNPGASSAVMQRGTITDLAASTLLAEADVGIVRISLGAPTNFMDVWRLVRFLRMLTDPQWVSAEWRAYERLHPGARLSNNIDHLHALATGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEZ3</accession>
    <name>W3VEZ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEZ3"/>
    <dbReference type="HOGENOM" id="CLU_027272_2_1_1"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="8">
        <location>
            <begin position="374"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="470" mass="52173" checksum="86D3600885F231E2" modified="2014-03-19" version="1">MASTSDDFTKRKLWGGRFTGKNDPLLFAYNESLSYDKRMHAQDIRGSQAYARALVKTGVLNEQERDEIVAGLEKVGQEWKNGTFAIHPDDEDIHTANERRLTELIGSVGGKLHTGRSRNDQVATDMRLWLIDEVKAIEGYLSDLIQVMIARAREEVDALMPGYTHLQRAQPIRWSHLLLSHATYFASDLARLRDLQPRISVLPLGSGPLAGNPFAGLDRDAIAADLGFQTVGPNSMNSVSDRDFVVEYLMWASLTAVHLSKMAEDFIIYSTSEFGFMQLSDAYSTGSSIMPQKKNPDSLELLRGKAGRIFGQMSGFMMSLKGIPSTYNKDLQEDKEPLFDAVDTTKDGLQIATGVISTLNIFPDKMKAALTPDMLATDLAEYLVRKGIPFRETHHISGSAVRLSEQKGCLLSELTLDDLKSLSDKFGDDVMQVWSFEQSVERRDAKGGTSKRAVLEQCDTLQKMLSSATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF38</accession>
    <name>W3VF38_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF38"/>
    <dbReference type="HOGENOM" id="CLU_337698_0_0_1"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000159">
        <property type="entry name" value="Related to DnaJ protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="667"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="827"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="887" mass="95870" checksum="256118A3F218AEB1" modified="2014-03-19" version="1">MDEQDPGLHFFPDGNVDLYGTLAVDKDATQDQIKKAYKKLALKFHPDKVLSSASSGGAEDAIQQFQKIGFAYAVLSDEVRRRKFDNTGSTAELMFGEGDADFDWNDYFKQLWTGEVSRQTLDDFKRKYQNSSDEKDDILEAYNDTNGDLAGIFDHVPCCEFVADEARFIALIDDAIAAGELKATPAWKRSKSADGRKALRAKAQGEAAEAEKLAKELGVWDDLFGDGKAKASSTKAAGKDTKTKAARGKAKPSNDEEDDLGGLAALIQRKSQNRASKFDDMIAKLEAKAGVKEKRPTDEEFDRIQAEMLARKNGGAANKENKKRTAASSASTAAAAGTASKKKAKNEVPDFPNQNLLDLAFQGRLRMNAPILGQAAAALALGLSSSEAITSSQPSPFTPSTPQRNNTTSMVGAAFGRATLQAVARATTASSSSLGFTPSSSSRITAALQASARSSSLGQRYLHAVSSTTQVATTPPVAVKIATTTAQRTRKERRTAMKEQRKAAKRKIAESSVSARLGVSTTTTSPFVRKDRQFKTFKPITRSIRWLRQPLNEHLHSGKPERSLTIAKRSTAGRNHHGHVTVRGRGGGHKRRIRLVDFYRWESGEQEVLRIEYDPGRSAHIALIEHKQTKRKSYILAPDGLRAGDTVQSYRLSGANEATSRATIITDEEVSADGTPLSTDALSTDPAAPQTAVEPSAASTDSGAGASSSLDLGIFRTQAIRPGNFLPLHLIPIGTTIHSITMNPQGPAKMVRSAGTFGQLVAFSARSGAGESHAQVRLQSGEVRLIPSRCCAAIGTVSNKDHQHRRLGKAGRSRWLGRRPKVRGVAMNACDHPHGGGRGKSKSNMHPRSIYGHLTKGARTRKPGTRSGNQMVVRERPRRNGKRLGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF53</accession>
    <name>W3VF53_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05795</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF53"/>
    <dbReference type="HOGENOM" id="CLU_117291_1_1_1"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="127" mass="14657" checksum="F63A8368BDB51D8D" modified="2014-03-19" version="1">MTRTRHGKKTHHARRDVKRGMRTRARKLDPDQIQANLNNPQRLDELQNPKELDVDKAGLGLFYCVECDRNFPSQKDQLTHIASKLHKRRAKKITEEPAYTIEESLRAVGMGIDNKQRTKPEATKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFB6</accession>
    <name>W3VFB6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lincomycin-condensing protein lmbA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_06441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFB6"/>
    <dbReference type="HOGENOM" id="CLU_014813_3_1_1"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS59522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="63261" checksum="3D8DD6344F80BA49" modified="2014-03-19" version="1">MASRAAFDWSVTDPHHNASYMRFASRRSTVLSTKGVVASSQPLASSAGIEILNAGGNAADAAVAVAAALNVTEPCNTGIGGDAFCLFYDAQKRSVRAFNGSGRAPQAMTLDVLRQKGVEGVEIPGNSIHSVTVPGAAAAWIDTVEKLGSGKLSMHDILAPAIRLAEQGYPVHENTAYLWGRSEKLIKAASANADEMLFEGRAPRTGELMRMPNLARTFRELATKGKEGFYTGRIAQAIVDLVKSQGGVLELEDLEDHLERGTEEVTPIQYTYNHPAKAGDLAGSEGVTMYECPPNGQGLTTLVALGILDELQNQGKVADLATLEHNSVEYLHALIEALRLAFADTRYHVSDPHHSEHDVAKLLLDQRYLAQRAQLFDASRASVDLEKGSPANTCDTVYFSVTDKDGNACSFINSNYAGFGTGAVPAGCGFTLQNRGAGFTLTEGHPNCIAPRKRPYHTIIPAMATRGDELFLSFGVMGGFMQPQGQVQVLINILHHGFTVQDALDAPRFCIGAGMAGPEGATSEVYFEEGVSQHVVDQLEKMGHKVKLVSGWGRFQFGRGQVIQKVHNDAGKLVWAAGSDPRADGQAIAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFD6</accession>
    <name>W3VFD6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFD6"/>
    <dbReference type="HOGENOM" id="CLU_439537_0_0_1"/>
    <dbReference type="OrthoDB" id="3365304at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="622" mass="67548" checksum="1F82F13FC7440F4C" modified="2014-03-19" version="1">MENALQSLTNTLEAINSRQAAARRRARKGVDATPFTSAVLNRERLDIYTYIRDADAHTEANLFWYPPVPQSASASRAGPSSSTHNRSAHSTRSSSAAHLGDDTADANLLLAPRLPEPRQVAPPTPLRNNHAGSTFQGQNQANDDPRLLLMAALRLNETCGKGTRTRKYIKGLLKTHSNLAQSIKSYELQIRQSEAELRANAEGRPGAVASGAGAAHDASHPDNAASALDEANMLLSEVQESIRKEELEILALDEMIGELRQARNDRQKQELQKQQQAALAADVTLQTHERSALRVLPRESLGRSAADDARAQQAVREASQPPAQDDEQELLDSPLDVSNQTADADFVAEEADESAMVAQVQHNVDETVEPDSSFASSHHDTLLQQSSNADADLTIQHGEQDHVESDDANELADNSAAILPADIPVEAVAAHTQESAPSHLHVPAQQSSDELERVTQKVWEVFGDALRFVAPERESSSYADTLDVLKSLMSGGDRPNLGDYSVGSVQTSSTTTTTSEASGAATAAQLTPEVLMTAFVIFQMLVSEEPHQLNIDELKVRGHEWWAASGMQVWMQARSHEEGEVPSRIEAFEDGQNLARKATYGMISKQLFAIRRQKGVGLVGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFL5</accession>
    <name>W3VFL5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFL5"/>
    <dbReference type="HOGENOM" id="CLU_073146_1_0_1"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="4">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="226" mass="23785" checksum="EFF1849FE990333E" modified="2014-03-19" version="1">MSTDLNVDIHNVPSEADMDVSSALSQPLPTTPAVARTEAMSLLALQKQLDGSMQRHLDVLAANGVTMQTPLIDAQGFPLANKDLMAIRTARQRINVLRNDSHALRDRVAKLLELAINGDSLESSSTSTAQKKVDLDAFARVNSVADSSPAQAAGLREGDRVVKFGSVTAQHPQGLAALAAQGVVVDGTPIQLLVSRGYSSAPVEITLVPRAGWGGRGLLGCHLVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFM3</accession>
    <name>W3VFM3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFM3"/>
    <dbReference type="HOGENOM" id="CLU_652459_0_0_1"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="97"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="421" mass="46943" checksum="47C4974033A332DE" modified="2014-03-19" version="1">MTPKRQSSKASPSDPVTQLAAGPAEEQPALNKDGSRRKSRVLRRKTDHSVIERRRREKINEKLVALQNLVPACRKECRDLIERKFAEAATSAPSAKRKREEEKLAKAQIEMQEKIKTSMVLEKLCIISHTLDFVNQLQEENEALRALCECQAQSKRRFSITSDVEMDEHYRDAHNLEAPTAATSNGEYRDGKAADDQKRECLSSPEPDLLPETAYRNVRRRLHWGSDRVRESCSLTEGVCRHHEDQDVSQADDVLSHRCLSTSSQGGSTSPPAADCKALTLSPGGERECGSVSGCRSSVCGDSSCRSSLWTKDSSCREEEALSSSASDEPASPPPAVASWREPGSTYRQALPNRHLLPSILHLGLPNCDPHHPVLRKENAYSMHRKYPTHQRDLASSRAFRPLSLYTSQPSRPLSSSTRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFP1</accession>
    <name>W3VFP1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="17">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PaG_05310</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24 17">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="17"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFP1"/>
    <dbReference type="HOGENOM" id="CLU_313544_0_0_1"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000005">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000032">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="20">
        <location>
            <begin position="515"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="21">
        <location>
            <begin position="688"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETS60468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="934" mass="101584" checksum="410C35B16E76329E" modified="2014-03-19" version="1">MSLSSKLGITDVDLKDKKVLIRVDFNVPMDGDKITNNQRIVAALPTIKYAIEKQAKAVVLMSHMGRPDGKPVPKYSLKPVAAEVSKLLSKDVEFLPDCVGSATEQAVAAAEGGKIFLLENLRYHIEEEGKGTNEAGEKVKADANKVQEFRASLTKLGDVYINDAFGTAHRAHSSMVGVQLPQRAAGFLMKKELEFFAKALESPERPFLAILGGAKVSDKIQLIDNMLDKVNSLIICGGMAFTFKKTLDNVKIGTSLFDEAGSHKVAELVEKAKKNNVELVFPVDYITADKFDKNAKTGSATDAEGIPDEWMGLDCGEQSRKLFRDTITKAKTILWNGPAGVFEFDNFAGGSKAMLDACLEAEKNGSTVIVGGGDTATVVAKYGAEDGISHCSTGGGASLELLEGKTLPGVKELSENGGPEGVARPSQWIRARFGLSLWLGPGLERWARARPLISQSGLGRSSSPLATSIIHTRLHQTGTLSSPSQAQPPSSSSSTPSTPPARSNQTANMPGQSGKVLLAYSGGLDTSTILAWLIDEGYDVIAFMADVGQEEDFEAARSKALKCGAKDFILADLKREFIEELIFPAVQANAIYEDVYLLGTSLARPVIARGMIEAADKTGCQYVSHGCTGKGNDQVRFELAFYGLKPDIKVIAPWRIPEFFNRFAGRSALLEYAESKGIPVTQTKAKPWSTDENLFHISYEAGILEDPNTTPPADMWKLTKSPETAPDTPENIVIEFQQGIPSKVKVASTGKEHTDPVDVFLTLNQLAREHGIGRIDIVENRFIGVKSRGCYESPGATILRAAHLDLEGLTLDREVRRIRDQVITTKFSEQLYYGFFFSPECEFVRSCIPQSQKTVNGQVKLKLYKGNVIVEGRSSEELLYDEKFTSMDEQGGFDSAATSGFITVQAIRLRRYGLGLTERGQAGSDRQTAYAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFT8</accession>
    <name>W3VFT8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_06615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFT8"/>
    <dbReference type="HOGENOM" id="CLU_017893_0_0_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002075">
        <property type="entry name" value="Probable RSR1-GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="298"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS59682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="687" mass="73963" checksum="A37F94367E218D8B" modified="2014-03-19" version="1">MAEKSLAPSRLGPAATQRQTAESASAREIVPARPFACTGSVSLAWLLHFARAPLLLTLILDLLHGSAKLLRAQSHVLAQGSATTQAYDTFYLKREQYAKEHGTRCSPIYHTHTANDAARRKPRIANMKEARVVIMGGGGVGKSALTVQFVRNVFVSTYDPTIEDTYRKMLVIDGQQCMVEILDTAGTEQFLALKELYIKSGQGFILVFSLTSLASVNELGPLREAIVRIKDTTAIPLVLVGNKSDLRADRQVPREVGTSLSKAWGNVPFYEASARKRINVDEIFADVVRQIRAFQTINSRPGTRPGTSSGASGKHGFGANGSSSHSGSKDSRLAGSSFGTSSKARDRKKGVRLHYAAAGPNSGFRPTRAGAEWSKAAHAAPIHTIAEFGQGSPAVQQDNASIGAGVIEAHTATKGGIMSRRYDSRTTTFSPEGRLYQVEYAMEAISHAGTVIGILAKDGIVLAAEKKVTSKLLEQDQSSEKIFTVSDNVMAGVAGYTADANSLVNYARNAAQQHLASYDDDMPVEQLAQRLCDYKQGYTQFGGLRPFGVSILYAGYDDHHHFQLYHSDPSGNYSGWKATCIGNNNGTATSLLKQDYKDDIGIQDAMAMAVKILSKTMDSTSLDSEKLEFATLTLNPTTHKPQTNIFKPNDIDRLLQKHGLAKPKDAEEAAAQATASGADSSAMAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFX5</accession>
    <name>W3VFX5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFX5"/>
    <dbReference type="HOGENOM" id="CLU_2145544_0_0_1"/>
    <dbReference type="OrthoDB" id="10468439at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834122" evidence="2">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="119" mass="12256" checksum="645AC6F19EFB18B1" modified="2014-03-19" version="1">MRVSTSCPSVGLSMVSALLLLVLVGMVSAAAIPARSGSDAVSQPVKRSIIEDLTEEPVTPGQPPNSAASLRRGWPPLPVPGTGGPSPNPKGRSDAGQGRKDPPPADVSKDFRLFISAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG03</accession>
    <name>W3VG03_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG03"/>
    <dbReference type="HOGENOM" id="CLU_874720_0_0_1"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF23">
        <property type="entry name" value="JUVENILE HORMONE ACID O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="313" mass="34421" checksum="DB09256CF555E4CA" modified="2014-03-19" version="1">MALISWAAERACALLHAVGLAPSVPEPYADRLAKLDPATSSLDNEIYDSHTFDWSRSGLALLNPVRVNYFLDKLHRLVSTLDPAQSHTITILDLGCGSGIAVEAIYDAIAHSHTRVTADGIVDGNITYKLLGIDMSSRSIELGRQRAASRGMSIEYVVGDIYALPFSSASIDAIICSDVLEHLFDLRSAFSHIARVLKPNGVFSFDTINRTPTSFYLTIWILQEILRAMQGDAHDHRLYLTPQEAHTLMRDSKLIPGPQTDLVGMRPRIQLSPIAIYKLLTGAGFISSCLTTFTQTSDLSISYLHWCSKPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG10</accession>
    <name>W3VG10_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG10"/>
    <dbReference type="HOGENOM" id="CLU_030884_2_0_1"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="57509" checksum="B87BCC269BAC0061" modified="2014-03-19" version="1">MSAKPASVDRVVVDDASSNPDQKSLTSVSDHAIPRAAPEQGSTKQTFLEIIGLRDPKPEARPVWDGRNPSWFRSTFFQITVLGGCSFLAPGIWGAMAALGAGGSQDPSTVNAANSLTFALMVVTSLFTSSLVGKTSVRFALAFGTMGYAPYAAGLYLNSVNQTQWLIILGAALCGISAGTFWSVEGAIALGYPERLKQGKYIAYWLMFRVLGQLLGGIINLALNYSDSEAGSISTNTYLVFVVLQCIGPLVALLLSPPHKVQRTDKTPVYLHIESSTRRELKLMWKLITRRDVLLLLPIIWQSTWSEALIGTYAVSYFSVRSRALGSLLSAVTASIANYILGFFLDSRRLTVNKRAKSSFIVIYALQAGWWAWAIYIMNKYHNTTPKPTFDWTSSGYGVGFAVYIFLQAGFNLQYEYNYFLIGQLSDDPSEIIRLASIVRGVESAGQCVSYGVNSTSFRLDAVAGLNTAQWALSILPAWLVIRKVGILADGTKIHEPRTYAAEEDRKKLKQSGLETAEYDLKGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGH8</accession>
    <name>W3VGH8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGH8"/>
    <dbReference type="HOGENOM" id="CLU_015166_16_2_1"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="113"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="212"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33131" checksum="C37EAABC6C4D927F" modified="2014-03-19" version="1">MAELNSLPKAPLLSQGNKDVLSGTVGGIAQVLVGQPLDILKVRLQTSPPGTYTGMLDCATRIVRNEGPLAFYKGTLTPLLGVGACVSIQFGVVEALKRHFSSSNLAAGRAADLSYSQFYLAGGIAGLANSFVAGPVEHIRIRLQTQPSPPLYRGPLDCIRQITARSGLLHGVFRGQMPTFAREFHGMGMYFLTYEALVQRKLANDRITRDQLPGTYAMFAGAMAGYGLWLTAYPADIIKSKLQTDALDPAKRRYTGTLDCIRQTFRADGLKGFFRGLLPTLVRSPFANAATFVAFEWAARNLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGM1</accession>
    <name>W3VGM1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGM1"/>
    <dbReference type="HOGENOM" id="CLU_1563519_0_0_1"/>
    <dbReference type="OrthoDB" id="10478944at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="171" mass="18307" checksum="DC5CDE8F98C427A5" modified="2014-03-19" version="1">MQTNGLSPPTPPLCLAASPSRLSRSVGRSEILSQKATSALPWERGGGIAARARNPMEFEMADDSRKTQAWPLRPVKGAATPRGRQTDEVQDPRVSFKVPHNVEGASGDGRERKSGRRSSERAGRASKIRASEQHSIKHVAGLSLGKTTWSVSPLIIGGCLSDARGPRYAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGM7</accession>
    <name>W3VGM7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Family 26 glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGM7"/>
    <dbReference type="HOGENOM" id="CLU_043977_0_1_1"/>
    <dbReference type="OrthoDB" id="428177at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079:SF6">
        <property type="entry name" value="GH26 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH26" evidence="5">
        <location>
            <begin position="3"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="375" mass="39691" checksum="C183E6522ECA9CBF" modified="2014-03-19" version="1">MNLQPRAVAEPLRLNNIPIGFIPDVGSDGGNVQTMVGINGLLAGRGQSYSYGFYDQTTYGTIYNGQKILNNAPDIYASGAILEASIMPVGSWGGFTATDNSQAKAVCNVMKKFTDAGVEVRLRFAHEVNYYVTTGEYAPMNDMGVSAFKTAWAQVSAACKTIAPAVKMWYCPNAANLSVYETYMPDNFNSTVQMIGVDFYPASNDLATAANYIQTVKPFHDKYSSSSVPFVIAEAGTHALDASLQDRINWLQTLSSSEVKAALPNLESITWYNALRKTDILSNGVGGDFRILDPNNATFPNQQAQQLFPVVQDAQASASVVSVATAATATATATAPASLPPSLRTGSGAPSTKKGLSVAGLAVTALAAISALSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGX8</accession>
    <name>W3VGX8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGX8"/>
    <dbReference type="HOGENOM" id="CLU_048129_0_0_1"/>
    <dbReference type="OrthoDB" id="2547118at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="340" mass="36477" checksum="6FE1E7436A75A219" modified="2014-03-19" version="1">MSSTKAGQVPSVGAAPALATSPRNVAITLKRAASNLSTTCSSDEIQVIDEQQPAIAIRPPVEPGYANRHSELECGSVHACRRHPSPLYERRKQDDLDLLGDSLDNGPCASDAFCRQDAYTRGRARGTKRLPYPKPTDSKRCGQPWQTGGHRVLRLDHDRQDVGNGLNACTYTCFESEDGSHASGGRTPAKHSSLLPPSPFGAEHEAVVFDNFEESGPTTPASEADADAKDPFDTHLRFVRPALPICANPGAFAGLESANETAVSCSDGSEGDSRTKQVCNTSDRVRQARHHRAVSELFGGPMAPIGANDMRATRRRATIGSDAAHPRRFANLARRGDQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH11</accession>
    <name>W3VH11_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_06007</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH11"/>
    <dbReference type="HOGENOM" id="CLU_040185_0_2_1"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="135"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="369" mass="43005" checksum="99C9C1D671605DE6" modified="2014-03-19" version="1">MADTSSSHAEPPAQAVSKNKRHRKDKPWDDDTINHWEVPKFTPDEIKGPFLEESSFATLFPKYRERYLKEVWGHVTSALDKHGIACTLDLVEGSMTVKTTRKAYDPYIILKARDMIRLLSRSVPFPQAVKILEDGIECDVIKIGNLLRNKERFVKRRQRIIGPNGSTLKAIELLTGCYVLVQGNTVSAMGPFKSLKEVRRIVIDCLKNVHPIYHIKELMIKRELAKDPKLAEENWERFLPKFKKRNVKPKKSAEGEQKKEKIKPKTYTPFPPPQQPSKIDLQLESGEYFLKPRQKKHAEEQKKIAHQQEQKEKREAERQKAFVPPTEPAPSKRKRDDQDDEEPAKKDKKDKKHKKDKQDKKEKKEKKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHC5</accession>
    <name>W3VHC5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear matrix protein p84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHC5"/>
    <dbReference type="HOGENOM" id="CLU_324686_0_0_1"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="933"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="954" mass="105499" checksum="006922FFBEF942EA" modified="2014-03-19" version="1">MEVDERGCASEARKGSCSKRVEKGLRIPILRLPSRGDPDFFAKCNAPWPSHPTLRTLTLLPHPLLPSQLRAMSSTELAAERLRQCISELSTPLLAALSELRSTQPQQILVPFKQVRDRLGPLVDQENIKQAFGLVENLSAADKDGPEVRVRNLCLEISNNELRKLVLESTPDLTGNSTDEPKSQTSLEAAFDRLDAVLVLSLHDLIDPTLPLSLVEELLEGLPISTCSQLFAYTESRVKPLTVDLHPTRGKGLVLLRTCNELLRRLSKPSQHHTVFAGRVLSLLAAVFPLGERSGVNLRGDFNVENKTHIEENDGQAAEEANIDADRDERDEIFKVDYDFYELFWKMQRFFSDPPLLMGASESSRPSTRSATPALHTEAADTDNVQADDDPAPDGAKGPMAELRISTRKILKLFAAVNKREKELAGAALAEEAKSGENKGNNASQANSTRSTPSLNKRRADGRGYASATGFYVGQFIGKDDAPPPAKRLRPDVVDGVKMDGRDAPDTPMDDEDDAESEAAHAESEHFFPTYLTGRKLFEYEIRDTSFRKHILVQYLVLFQYLLSFTPTAKESWKDWKNKTLQALFTLEDVDERWIRSTWREILILIRDIQPHGRLFLESVLEVLKREANWIRWKTESCPSIEKPPLSPEQISAFASARALLLRKPEPYPHKLGTAALSELWLDGLRPPVAGTRRVENELGEYISVPTDGLEELEFLPPIPSVEHYNKSIQREKMKLDLRKKQLGIDTAISEAQLSKEDREKLDKDERIQATIETMQSLAWRALRVASRDHLHLFGKPERPEHIEGLLEAIETERNPKPKSVAPVETQATEEGAVQAQGPQEAEKAAEQGAELVQADTADGPADAGVTRTNEEINPDSAAVGSSAESKEQAASHQDGAAQDESIVPVMIPAVPASPAALTPSADAKKTTETPDVEAATAPATTAEQDVEMAEATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHG2</accession>
    <name>W3VHG2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHG2"/>
    <dbReference type="HOGENOM" id="CLU_048479_0_2_1"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47389" checksum="3C2FB276D6741F73" modified="2014-03-19" version="1">MVPKASGSTSLLTGARKSGISLALNGGGGQPGGVSLHDRLSARSRVTNLGVVLLLGFAALSGLMNLRYMLFSRHSNAPPLGLHSWQSFHGYTPDQLSNSVPPPRNGTDHLNHLVIVTGHAIWAGCDVKGKDRDENWVLEDYQKGGSVKTFYKHIEKGLQLTNEDPSALLIFSGGQTRPNSLQTEAESYFSLAVSAGLELPMIAGSLSNSTSASSSSSSSSVGQLAHANAAVATLHGLQDARMTTENFALDSFENLLFSIARFREYTGHYPGRITVVGYGFKKGRFEELHAKAVRWNTQGFLRNGERTFQYVGLDDDISEAESQLQYRGEKVKAYNLFDKDMYGCHGRLRDKRIERNPTRRFHPYMSSAPEIADLLNWCPAPNSGLQGLYPENLPWDARVIGTGWGRGALEVKKNSKGNIIPDTRWLQIGREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHP1</accession>
    <name>W3VHP1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHP1"/>
    <dbReference type="HOGENOM" id="CLU_001762_0_0_1"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04400">
        <property type="entry name" value="RhoGAP_fBEM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000049">
        <property type="entry name" value="Related to BEM3-GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000066">
        <property type="entry name" value="Related to BEM3-GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="432"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="571"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="876"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="698"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="836"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1182" mass="128324" checksum="33B8C2F5C7D2F30B" modified="2014-03-19" version="1">MASAPARPPRFGIDNAMDSTGMYANDANSTASHGSSSRFAPAAGTRSTPAPTPTALADVLARADGDHVAALDQVLAERNQFCLDNAKLSSENVRIWNLMGRIRKENESLKARCVELERASAAAPAARGSPLGSTNSATPGSPAGGRRRMPYGQEIERSSSPLSSPRHMRQNSRSELDQRLALAGQTTNSATYRAPNDNGNGVSSAPSAPAPESASVLSDTIGSTHAYDSPVTSVDQGPSRSTQPVDTGLDRSIHANADHQASIMQQRAAAQAQAQSMSLNQWAQGPDTLADSLASHESADFEAVDRSSASGTDENPHLHQSATHPPSSAHDRHRTPVQQPYAAPSGIPASPYHPSVDRAVEQERSLLASGPNRNRAEITPTMIPSSASSRSLVSKVVSEDRLSRGTGSRRSKDDVKKHRVLAPRLDSSLLRVASVKIQGTNYRSPDRGKEAISFLITVDILHPPASWGLNSMASGEPSPPTSWTIEKSYSDIIGLDAKLRSKVGKKASQRLAPLPDKALFKDHAPAKVDQRKALLEIYLQSLMVLELPDKDEVCTFLCTDVVPNRLRDPLSTSKEGFLTKKGQNLGRWVTRFYVLRNSFLSYYETRGGAQIGSINIRDAQIGRQQKSTASSEQDENAYRHAFLILEKREGMPDEPAHIARHVLCAESDEERDDWVDVLVRAIAELDGVSMDDMPASPTQAMSQMSLSQQATTPGREALGSNARFPDSAFSPSADKAGRQFGGDAGQDGSRSVAARMNSVDSSATGKPVGSTPGSSLPQSASYRSFHEPRSPVSSRGADLYDAPGSPGPRNEPLNRGKTSISGPLNGAPIPAGYKFGAKDDMGPDSKKDDKKRFWQGFRAFGGSDKHNREPRPVFGVPLAESIAISSIHEGLALPSVVYRCIEYLEKRNAFMEEGIYRLSGSSAVIKNLKDRFNMEGDVDLLTENQYYDPHAIAGLLKTFLRELPTSVLTRELHMDFMRINELQDRVERVNELGRLVSQLPLANYSLLRTLCSHLIKIIEHSDVNKMTMRNVGIVFSPTLAIGAGIFALFLTEFDSVFETDANGEPAPRRIGEEQVEGQQQQEVEHQTGQVHDETSARSKRNSVQYRESQADKLLGLEGRSLSHQAVDEDMEGIGEEAWAEQRRASEPAENGQMQYEQAPQTYGHHHGGEMHGQHNAPSAIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI56</accession>
    <name>W3VI56_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_05336</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI56"/>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_1"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="104"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="374"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS60492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="757" mass="85953" checksum="5E76C1779F665F3C" modified="2014-03-19" version="1">MSSSAPQPVASSAQAADPVQNLTDAAQNVDLNAKPQQPKQPKQQQQQQQPKGEKKPKAKKEGADAGPKAPLEFSPKPAYFDHRIAMFEKLKAEQDAEFAAKPRQPITVTMPDGSKREGTSFETSPMDIAKAISKSLSERIVISKVDDTLWDLERPLEADCRLELFDFESPEGKRVFWHSSAHVLGEACEKHYGCHLCIGPPTEEGFFYEMAMGDSGDRMISQADFGALETLVKNATKEKQKFERLVVSKQQLLDMFHYNKYKKHIIQSKIPDGTSTTVYRCGPMIDLCVGPHIPHTGRIKAMTVLKNSASYFLGDQNNDSLQRLYGISFPDAKQMSEYKQFLLEAAKRDHRKIGKEQELFMFHELSPGSCFWLPHGARIYNTLQEYIKSEYRGRGFDEVITPNMYNSKLWQTSGHWQNYKDDMFALGVDKETFALKPMNCPGHCLMFASRDRSYKELPLRLADFGVIHRNEASGALSGLTRVRRFCQDDAHIFCMASQIEHEMAGCFDFLQRVYGLFGFTFKLELSTRPDKFLGDVETWNAAEARLAAALDKFVPGKWELNPGDGAFYGPKIDITISDAMRRHHQCATIQLDFQLPQQFKLEYRTAVSQGGETQAERPVMIHRAIVGSLERFIAILTEHFAGKWPFWLSPRQVLVVPVTASVFDYAKKVQQQLWDQGFYADVDLSDNTLPKKVRNGEIAQYNFVFVVGHEEMQTSSVNIRNRDDVNQKGKAETMPLDKTIQLLSSLKHERRLENKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIC1</accession>
    <name>W3VIC1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIC1"/>
    <dbReference type="HOGENOM" id="CLU_063514_0_2_1"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="156"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="266" mass="28858" checksum="6264ADAA638A13A3" modified="2014-03-19" version="1">MSRVELLNAGGFRVDGRKQYELRSIAIQLGGSEDTTADGSAQITHGLTTVSATVFGPREARSGGNMLHDRASLNVEVALAPWGSMERRRRNRGDRRLVEFASAIKSTFEPVVHTHLYPRSQIDIFVHVHQQDGGVLPAAINAATLALLDAGIAMHDFVAAVSCGIHSTAALLDLSNAEESDLPNLTVAVLPRTKQVTLASLETRLHVERFQQIFNLAIDAAQVLHNEMQLAVRDRTKTLVQAMTGKHVDAAPLADSDSDHDDAMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIJ4</accession>
    <name>W3VIJ4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIJ4"/>
    <dbReference type="HOGENOM" id="CLU_1496859_0_0_1"/>
    <dbReference type="OrthoDB" id="10362239at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834213" evidence="1">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="180" mass="19291" checksum="53C1BE4D71BF2834" modified="2014-03-19" version="1">MRLFLSFALLVITAGLLAQASSLADLAARHGYLWDGVTFPTPIPPYIANNGTTALDVAKCLEGTGQYHIDVEEEMYIVMYLEESHEANIVNCLFLTAAGMRVAHQHRDDLATLPTAPHEPSSQGVTFGLNIDPNAVIPPTCAPSDFQSGALATNQTKMVTSGPSSFGYNALAFKDDTQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIK7</accession>
    <name>W3VIK7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent mannitol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIK7"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000421">
        <property type="entry name" value="Probable NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF6">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="34612" checksum="B88A223CDAD868DB" modified="2014-03-19" version="1">MPSHVLAALSVCVWGRPTGLAPHNARRRSTSDPRLSIELLPRLGHCSACAGKTDPDSSFLPSKMPFVIDLKGQTVVVTGGNRGIGLAMSEAVAAAGANVAIFYRSHPKAQEAAEQVAKKHGTKVKAYQCDVGDAELVKKTMKQAQDDLGQITGLLANAGVSVVKPAVELTSEDFRYVYDTNVLGVFNSAKAAAQLWIESGFKKGSIVITSSMSSEIYNQKGLNDPLTQVFYNSSKGAVTNLGKCLAAEWAQHGIRVNILEPGFCNTEQTSGMDAKIRDFQASSIPLGRFSEPHEQAEPAVLLLSDKASYMTGSVIRPDGGFTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIN8</accession>
    <name>W3VIN8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIN8"/>
    <dbReference type="HOGENOM" id="CLU_010119_6_2_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="343" mass="37615" checksum="39BCFA3CD59E6AA5" modified="2014-03-19" version="1">MSGAAPIPIISLGAGEGVPALGAQILDAVVKTGFFYLCDHGISQDEIDALFRCSAELFLEERESEKLACQDRANNTGYTPLKQESLDPNSKSEGDLKESFYLAGLARAEGGSAPVEERYRPPSQRLPPSLLARREAVAEFIEKCKRISEAVLTGFAEAIDLPPQYFVDAHHGEHDRLRLIHYPPTGVCTSDASKSSMSIRAGSHSDYGSCTLLFQKDVGGLQVEMQPGEWVDIPPQKGCIVVNVGDAMEFWSAGLFRSTQHRVVLPRSESESGSRFSIAYFCQPDEDARLVPLPIPETVRDRFSGKMMDQHEFHSRCAAKGVADVAELTGGQHLRARLEATYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIU6</accession>
    <name>W3VIU6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microfibrillar-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIU6"/>
    <dbReference type="HOGENOM" id="CLU_028123_3_0_1"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="645" mass="70406" checksum="112B47186966A720" modified="2014-03-19" version="1">MSLPSEAPRRHVRVAIVGSGLTGLVATYLLTASQPHAPDAPRISVDIFERAPTLGMDSASITVPLPPPSPPQPEAAPPRLVKRARLDAKSNRAKDVATSMRIDVPMRAFTGGYYPQLLALYRHLGIRARKTNFTYSFARFTDASFKGERKAPEPSLLYNGANGVRGISLPASLMRMESEGIVRVSAVLQCVRRLRVYFGSLVVMVLGYVQLLIIALWHSMLGHTADANHPLRTHTLRDLVRDPFPRRSPRTSSSKLRYGAERLAEAVLRRVARLDERFVEQTLAPLFSAVMTCSLDAVWASPATEVLDYVALTLGRDHFVVQDGVRTVVRALLVHVAPGGEEESRVWTRAQVCRVHHRNGRAWLSVMHHAEGTEMSREPSSSSASTGTDATCIDDAREHGPYDHIIFATQANQTARFLEAYAASLDDEAERGRLGSVVEALRTVRYERSVVVNHTDRTLLPVNRRDWRDLNLVSPAASCETGLRRRGSAGSDWTDSSSDSSDTEAGQEGHTMATHVLRVPSYAPVVMQTTNPHPSLEPSQESVLSRAAFERAVLDVRAHVARQTLFTRSNRHSANADAVQTAGGTQLQLGPLQPVRAATDHAQVWVAGSWASGIPLLEGCVVSATLVAKSIVRAEGASLPSSAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIV9</accession>
    <name>W3VIV9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04483</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 12">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIV9"/>
    <dbReference type="HOGENOM" id="CLU_034178_0_0_1"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="279"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="296"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="348" mass="36291" checksum="412F2AEB25386E88" modified="2014-03-19" version="1">MIATAMLPRVSLRTAAASALPLRRGFATSRVDLANTLVFLEHKKGTFNPAALSALTAAQKLGGDIDALVVGSEAEASDVASKAAKLPGLKKVLFSKHADFANNLSEPLAPLLKKIVESNSYTHVCTGHTAVGRDIFPRAAALLDSSQVSDIIGLEGEDTFVRPIYAGNAIATLKSSDKVKVFTVRGTAFDAAALEGGSATTEEVKPDSVESPTDFIEEKVSESSRPDLATASRVVSGGRALKSSENFVKYIEPLADSLNAAVGASRAAVDAGYADNALQVGQTGKIIAPELYVAIGISGAIQHLAGMKDSKTIVAINKDADAPIFQVADLGLVADLYEAVPEMLEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJT6</accession>
    <name>W3VJT6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJT6"/>
    <dbReference type="HOGENOM" id="CLU_1897105_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="134" mass="14223" checksum="FE1CAD4B62E11541" modified="2014-03-19" version="1">MWLAALAFHPTASSPFARGGFITPSFPFLSISVTDLGQPASRRSPSLVALPLPAALHICTSIISAPAAFPNPSTRSAPSDAVLSSARPVPERPGMLTTARRSFTPHCLSSLDASRTHHPPVRHQPRSLCLDSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK23</accession>
    <name>W3VK23_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK23"/>
    <dbReference type="HOGENOM" id="CLU_432215_0_0_1"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="343"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="641" mass="68784" checksum="A4BE0E1543F44782" modified="2014-03-19" version="1">MASALSRSARYWGVGVSARPTAAVGTSFATQRYLSASVRHLDEHKPPHTGSSDAASSSSSTTAEGSSDNSSSSGSTGYKPPSRATGTWPFESNAETSESNTQVSASEASSPKSNPYAGLFDGSDPFPKVGSSSSSSGGSSSTDSTQDGAALPKTGSWLTEQLDSLSSSSRTSRVIGRSAQLNPNQKMSESERRKHLVPRSVLFADGEAARQSDELRPRKPSNSPRKRLDRTPLTKQEANAFMSLLNQALAGTSSPSSSSSSAAAAASMPGDAAEDSSALPFGSYTSLISNPKTQTGSKALLQAFAKRNRLQRFEAAKAQRARRFAREGLAAQIDPLLLEAGIDEAREHIAMCENLAELLDFAKREVWGIRPNTPSPSAQEGASTSDATAEAVESDPSTAKMAGPKYGKDTPYYSSVLQLLFVAIRDRYRAPHVALSLPRVTRSLGIESYVLGVTGLLYNEVLKTQWDWLGDLQGVVKTLRQARETGILSAPLKHASIPPGSSRPLYATTEDETIRETVDRIANEVRKFVLDQQMAAHPALRRGNMYGGALDDVLGGAAHNAHMPKTELTEDWSHTWLLANADEASALAGQPFRLLQRQADDADTTRANGPLRAYPKKAIRPGRDNREPRERTSPRQSSQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK41</accession>
    <name>W3VK41_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04019</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK41"/>
    <dbReference type="HOGENOM" id="CLU_000288_67_4_1"/>
    <dbReference type="OrthoDB" id="18472at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="165"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="466"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="565" mass="64454" checksum="A511D417371DBEF5" modified="2014-03-19" version="1">MAPVQSAVATTSVPSPLATSKKENTSSQPSLINDHIKPPKHSELSRINENNSDSQPDPKGSWRSWRRGDGLQPWETEIVRSTEVQRKANVAQLYFLNYYFDNLRYLADRKARLTRFHESTRARGLLPDDEDAEPSPEFLKERSSYFGRERVLLRKRRTKLRVNQFHIITQVGAGGYGEVFLARKRDTGEICALKRLKKRILVKMDEVRHVLTERDILTATKTPWLVRLLYAFQDPDHVFLAMEYVPGGDFRTLLCNNGALKEEYARFYMAEMIVSVNELHRLGYIHRDLKPENFLVDSTGHVKLTDFGLASGALHPGKIESMKAKLDAVKDSDFVYRTPAERGSMYKKMIQHTQHRANSIVGSPDYIAPEMLRGRQYSFGVDYWSLGCILYEFLCGFPPFSGSNPDETFANLKNWQKVLQRPVYDTPENMQFNLSDVAWDAITKLVDTPERRYSSLEPVQTHPFFRSLDLGRLRELKAPFIPELENEEDTGYFDNFEDPADMARYKDVHEKQKNVEAVRETGSGAGGRGMWAGFTFGKNGVGANGQPLYASSTVKDATDAFATMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKC6</accession>
    <name>W3VKC6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003616_1_0_1"/>
    <dbReference type="OrthoDB" id="2549237at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1703" mass="190519" checksum="6CEF706A318D10D1" modified="2014-03-19" version="1">MTVPEILVRLDVQLLSRASNADVVEYLRDQLRMHPEPAVRRSVLRLITIDAVPPTISRIWLETARDPNTLREALHQNHSAWLRSEAIRRLASILRGSHWRATWDALGSTEGIAQLLSRFSVYHIRQATKAIGRNVKGIDGHLKAQKRQAVSELLLHLVPSLRSPSYQASTQAGSFPEKRDLIKAYADLLSACTPELVHRVLFDAAHVVPLHGPQATLLREHHQVFLDRASQPGSNIFESNWADHASHRLEVVYAVVFPAAGQHDFASVTPFLSRALSSLVKQPPTSSSSLRRVRQKYADPLSNLLHRLVACPHWSLHDRRAAFDLILDTLQNHSRDHYSVRNALWKQAAQLWAESTELFQPVLVRTLNMASRSPSYLSFSQLQASVPSDKRWELLKLIQSTDTACPIDLDQDAGLKELLTHRNARRWPFSIFQALPSHQALNLLERLGAHLPRDQVVSMGGSSGISILNFGSASGFVDFDMARLELDPSIDAQERSKCANDAIEECKRKIANSPEPADRETLARQALSWATCSRSYQVYTDTVVWMHRFVRDVHVARSLFTPWSVHTKEAISLLSGIPQRPDASLTADVLRDDIAQANRAIWEWFEIVRAAAPEPSFKASDFSGASSIIRPVIIERMRRLERLQARLAFDADQVFALVWDDTVSLLIRIEEMCIDPSFRRLELYDIAGPLAKHADGYARSSPGIHVRSIAGLSFVEKLHAARDALWKSHRISFNPSVASLPRGIPQGLPLHVAPAMWSLDDVLPQAAASPLIQTARSIVFADPQTVMQPLPDDEETLDAIGEYHEDWSFALLLLLKAEQGQAAKLRLMREAWLHATRKLADPRLSRVEAETWWLTEVFEPAARQRIFPDPQRFAQRVPALQLPDAPAPDAVTWAPNALLVQAPKRSQKAPMTVLDTMIGQDVLDGLQDGSLRRSASASEKRSWNRSDALEKRRQAVQALKAGIVAPDRRSQPRETVRSFVEAHAALRLLLLDHNCPDGNTLELPFPIQSEVRYPQLVLREASLKTPESKLDLDQDVRQWLRPVLSTAPPTLLRCLAERALAARADGRLPKTSHLALDLVLCLQAGDRPSEALPLVLKIVLENRDDSSWHRILFSKGFLERLSAEDARDAVQGLAGEILARTGVPSTQPNTSGPSIKVSTVRLLAQAMEKAEYVDPSDAIDILMQLLDRAKHADIRHAALEALLASCCGRPSPSDAVSKALRSGLQRLVPILAALDETRPEGSALPWAEGALPHICEGPTMARRDLMGMRQLPRTWEPVMNALSAYKAWAPVLMQTVVVPAIEQSIELHQRWLDRFLREHDASTESVALPVPPVKVDILKRLVREHAYLTPDWIVQLYCDYLRAIMRPKAKVREINHALKQTVGNAARHWLSVYETPAISSSSHGRQLESLPFLSSFVQSLTEGAPDDVDVEEMVRSRTESIDAAARVVLEAFRVILESESVDLRTLGYVLQALAPPPRDSARKAVAQMRAWTQCARPVLARIVERIDALRTPEWQRNSARRPARLPSTLIEYRLWLLPYPSCDEAVAASELARQCREFGRALMEHIEALVAQAVPCHEEMERLHQAAMGCPTKQRGLIATAVGGWHGERGPDATSQMLVRSHCIDLAAKLVFVAELPDESEAWLVELKSMVEGWQQSDVEWIRERAQRVAVPDLYFVEFADAAIGDVVRAVVAHEKVEESEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKD6</accession>
    <name>W3VKD6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="11" type="ORF">PaG_03689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKD6"/>
    <dbReference type="HOGENOM" id="CLU_271915_0_0_1"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1198" mass="128001" checksum="F792A17ABE1E6942" modified="2014-03-19" version="1">MDDDPEQLFGKLLLQALSRRLSQSSWLALAHQLTRRIQSFQQSRGEDVDPTLAGTLAASCLVQHILSQDFIDPLLIEYLQALVYGSATRSGVDPDQGPVTDVITVTLYLLAHVDDATTKVSAIETVSSVIGQGLLVTFQTNAPFKIADPALLVLLQRLFADKEVQDPSSSASVVSPPPSPESTRGSDVAPAALRFIVSNLRLLALAADASIAAPQNLLAPRAAITVLMNVGSSLLAHVIQRLSTLQASKDRPAADTPLLQQTRSECKAATADVETVLHSMNPAWKDEIALLRSLSSQIGVIHQLAHSLAGSSTSSTLQLRGKKAETMQDAQRRATWDHFLDAAATTAADKPPVEPEMALLMHLVVDERLAWIAKLDAIKTLFLARRVAAAPSVTLEKSLTAFYFELLVAAIDACASVVEMPPGFKGAEVYAAIWRNALCGMVPEIVLQLEQWLDVHPDLPLRGQRVEAPHVRFERALRAALLAMADRLDVCETAVSQPAVPNGATDATTGAEMDVVGLDTPPSQPIKAWLLRACIEHSLARPEAIADEFPEGHKLASEVQNLAQSLRMDAQLEGLALNTLFETRVPSDDPMELLQRVASDPGTHCSFARQLVVQVHAWLEQHDLESIARWCRALGDDATHGGAMLDTVMLYIDPTELVDPLAGILDHQDLGQTSDEPATLSNIILFVQLLCYRYSVPPSRISRFTSGASGEMEVDGTTGSAEAAGGQPFLASYLASASVCYPLSVLGEEERGLVGRWVHALFGNEGISDDLIQASPPTTLLRLAPLLFAQSIGACVHGVIDLETLRGGLSYFLQDLLSFTLPGALAWLLAEIVRVPLQPILDVLAEAGLQSSVVDVPSSDGTLANGLPRNANSRTVHLEVVALLLDTDACPAIVRHLIARPFDAFVQAMEAGGAATLEVGSETFNMASLKARMEAAGVTAQLLSRRNSAWLRALANQSVAQQHASVTTESETITMLCGPNAVSSTLDRLMGAQGRGLAAHSVAEQKALATWLCLLAPQANEVHPALRFVERVQLADEANVEAALRTIALVLSLARAAEAVRGHDTSTTSAADAILALATSTETNGARKDSCAADLFDDEPTTPPLPSVNAHAATDSQSNGASTGQSVAALLSSRAFRLTSAQVEDLLARKLVRLESSTPAIWHTVEAALLDPSELGNDKGKDSAPKEKIKTWIEMLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKM6</accession>
    <name>W3VKM6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 69 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKM6"/>
    <dbReference type="HOGENOM" id="CLU_535506_0_0_1"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="67678" checksum="F4F61033D96D6AA9" modified="2014-03-19" version="1">MSLCPRAAAQALHSPPELHQHEYKQHAAYFDPQDHPHYTLHPSSRFGADNEPLLESSAPSDDHPNIAGIRSPQSLHSLLACRLARLVSSAVAASSSSSSSSATGSSASSRPSRKRWLPALLLLNLAVTVAAFVAACVHFNTFTTLFLYLALLIVAFPIFSLTFLLLNSNSASYKLRLPQFSPFSSPDFEQPSFRFSSNSQPPTAASTSRRSCRSFRLDRLARYVQYVLASLWFLALVEWLFFQPFFDTTSPSASDDLAIFLKSSPASRIAPPPQPLKVFIASNLYNSQDILPTYSASLKGLVHHLGAHNVFVSIYESHSTDQTKSMLSQLDADLAHLHVDRQIARDDGAARMNKSSPVQDRIEFLANVRNLAMQPLAQSAHAHNFSHVLWINDIVFTPQDAVRLLNTNNAHYDQACAMDFIGNGFYDTWVTRDAQAQTLKRQWPYFKQPHDIDAMRQGTPFVVNSCWNGMSAFDAKWFVPPKSQSAQPAQPPIQFRSSSTCLSSECQLVSYDIHRATHPKRPNILINPAVKVAYTHRHYRLYNSILSWPLVRPWRIVWRDWIAHRLFGWLTESRRWPNECQLKQPWWSTEPASKRKTPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKN3</accession>
    <name>W3VKN3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05268</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKN3"/>
    <dbReference type="HOGENOM" id="CLU_016502_0_0_1"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="167"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="11">
        <location>
            <begin position="485"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="716" mass="79735" checksum="A7AF80D59739C07F" modified="2014-03-19" version="1">MIAKPWELDKKALRRINKLPPEQRLDGIATYQHFNHNSYKVPCYSSFVIYGLFLLLILTASVNNFVAWAWPGAHDRCRRKLRLFRAYISEHPLIARKHSVVASLPGLRWLTLQLPLRGEAIILLCLSLANFLPLVAFYDLYVGDKNTFYPGPTSKRDQMYRHLADRTAILGTAQLPLLILMASKRTPLAIVACLGMNRLMLFHRWIARWVWLHILLHTAAFTAIYVQRGGAAGVALLLEDAYVKWGVVSLSMMFGLIFLSLRALRQWSYEIFVMLHILMAFFAVLGAYLHIALIHSSRFQLFVVMTEIAAGVWAFDRAVRFASRVFLSFSYTSSEASHAKKFPSIKCATALVSSLDATSSKYTRLRITLPASRLRLPGQSRLPGGIAAGDDIRVTIPRLQWVGEHPFTVFAVGLQQDSPAQGYVDLLVKTEAGITRKMSQLGDNRASTEPLEKDMEAASTGETGREVAVLLEGPFGLIPDVSEASHLVLVAGGIAVTFCWPLFVAAVKASKSSKLKSCKLVWLVRDEGLLKFVSESFEELIKEMDGKDNWNSCNFSIDLHVTAPSSTLSKVVQEMPRSEFVDTLAHLSSSTSLSSNEVKEQARSSDDASHKDMTPSSEFVNSIDEQQGGEKQHQAESSHSSQAHEDVIRIKRMLGRPPVLSTALFGHLDSDELREKGGLVVGLCGPPSLCDDVRVETVDMLKKGYHVDLVEDCFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKP9</accession>
    <name>W3VKP9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKP9"/>
    <dbReference type="HOGENOM" id="CLU_1993585_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="125" mass="13685" checksum="8A162B2EB7CD318C" modified="2014-03-19" version="1">MSATHDAQTRWNSTFENHPMRYVDPPLSPWTSRVLSSAGLSWASLAPPETEISHWALGRRVLPGRGDAKGSNSARFCFRSILFERVGSRELSPKPVPDPMGSIGRLGLLFPAPWASSLAATALRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL37</accession>
    <name>W3VL37_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03458</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL37"/>
    <dbReference type="HOGENOM" id="CLU_004553_2_10_1"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="280"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="583" mass="64331" checksum="A4CE80704B1AFFF2" modified="2014-03-19" version="1">MSAIKDALASAAEALHISGDKDKKAIGGGAPVYVDEKAGNDDAADGSKASPFATPLAALLAKGQDASVFVKKADATPGQDGVDADGYAPISASAAKKVSKLYATALKKKEKASEQAAKDEAQAAHDEKRLEDSKKIILEEPSSSAKKIKISQGANFRDQRVKICGWVHRLRSQKDLTFIVLRDGTGYLQVVLSGKLTTTYDALTLTTESTVEIQGQLKAVPEGKTAPGGHELVADYWKCLGKAPGGDEAYTNVVAETADPNSLADRRHLVIRGETASAVLKVRSEVLKAFRAEFDSLGMTEVTPPCMVQTQVEGGSTLFSFDYYGQPAYLTQSSQLYLETCLPSLGDVFCVQESFRAEKSHTRRHLSEYTHLEGELAFITFDDLLEHLEQMICGTLARVLDDPKTKALLDQLNPNFQMPSRPFRRMDYKEAIQWLNDHNIPNEDGQPHKIGDDIAEAAERKMTDELNVPIFLCRFPREIKSFYMKRTEGDEEFTDSVDVLMPGVGEIVGGSMRMADQHELLEAYKKEGIDAAPYFWYTDQRKYGTCEHGGYGLGVERFLAWLTNRWTVREASLYPRWTGRCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLL0</accession>
    <name>W3VLL0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLL0"/>
    <dbReference type="HOGENOM" id="CLU_008891_5_1_1"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="558" mass="60060" checksum="BDF5C2F4D47D9CD6" modified="2014-03-19" version="1">MAQLFQKDPRNAGLFIGGERLSGAEIRNQNVLAAQSIANIVKSSLGPVGLDKMLVDDIGDVTISNDGATILSLLEVDQPAGRILVELAQQQDKEVGDGTTSVVIIAAELLRRANELVKNKIHPTTIITGYRLACREACKYLQDQLSTKVDTLGKESLINVAKTSMSSKIIGADDDFFAQIAVDAMLAVKTVNPRGETKYPVKAVNVLKAHGKSARESLFINGYALNCTVASQAMKTRVTNAKIALLDINLVKQRMHLGVHITIDDPDQLEKIRARESEIVLERVRKILASGANVILTTKGIDDLCLKEFVEAGAMAVRRCRKEDLRRIAKATGGQLVSSLSNLEGEETFEASSLGTADEVAQERISDDELILVRGTKTVSSSSIVLRGANDYLLDEMERALHDSLCVIKRTLESGSVVPGGGAVESALSIYLENFATTLGSREQLAIAEFAQALLVIPKTLAVNAAKDSTDLVAKLRAYHNAAQSANAGDPKKALRFYGLDLLNGQVKDNLKAGVLEPTVSKIRSLKSALEAATSLLRIDDAITIAPEQPPEDPHAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLP1</accession>
    <name>W3VLP1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLP1"/>
    <dbReference type="HOGENOM" id="CLU_003824_1_0_1"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="751"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="55"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="992" mass="110072" checksum="0FCFA6EFF264A0D3" modified="2014-03-19" version="1">MNSNSSSSMRGLTQYIADLRACRVRELEERRINKEMAHIRAKFKEGQLDGYQKKKYLSKIVFTYILGYQVDIGHMEAVNLIASTKYSEKQIGYLAITLLMHENSDIVRLVVNSIRKDLDEISEVNNCLALHAIANIGGKEMAEALAGDVHRLLISPTSRSFVKKKAALTLLRLYRKHPDVIPADEWALRIIAIMDDDDLGVALAVTSLVMAMAQDHPHAFATSYNKAVLRMHRIVVENDFTSEYVYYKVPIPWLQVKLLRLLQYYPSTEDPTLRRTLETVLDTIINNSQESPKNVQHNNAQNAILFEAINLAIQLDTESAVVAKAAVLLGRFILSRETNVRYLGLDTMAHLAACAESLEPIKMHQNTIILSLRDKDISVRRRGVDLLYSMCDVTNARVIVSELLKYMQIADYALREEMVLKIAILTEKFATEYAWYVDTILQLISSAGDHVSDEVWYRVIQIVVNNEDVQEYAATKVLEHLKSTTCHENMIKVGGYILGEFGHLIANDPGASPIEQFHTLHSRSHLCSQSTRALLLSTYVKWLNLFPEIREQILYVLNRYRHVLDAELQQRACEYVALAEMPDDELLQAVCDEMPPFAQKSSLLLSRLHKKHTDTEDKRTWIIGGKDSNRGREEARLESLKKGKANGGAMPTGGNLGSVIRAGHPSEAVTADSMRNGASDDADNVLAGLEGLDMNATSSALEDAGLLSEQPLIGDEASPAASKVSTPATPATPATPVSAATFSAGSDKYFQRLCFAAEGVLYEDSQMQIGLKSEYHAHQGRLALYFGNKIGVNFSAFSVSVRSPDAALSVSVPKIPTNVLGAMTQAQTVVLVECHDLFTQPPVLEVSYLAGSLHEIRLRLPVLVSKFIEPVQLGATDFFERWRQIGGAPREAQKIFGFRLSSAGEVDVSRQRRIIEGARLQHLDGVDPNPTNSVAAGVLHMARAGKVGCLLRLEPNRDAKLARLTVRTTNDLASTELLRILLAVLGTDEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLQ0</accession>
    <name>W3VLQ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03101</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLQ0"/>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF2">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="31"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="509"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="571" mass="63824" checksum="8A43352D976463F9" modified="2014-03-19" version="1">MEPAPVFRTPRKRVAYYYDHDVGNFSYGLGHPMKPHRMRMTHNLVTNYGLHKKMDILRPKRATRDQMTRFHTDEYVDFLHRVTPETVHELTNEGTRYLIGEDCPAFDGLYEFCSISAGGSLAAATRLNSGESDVAINWAGGLHHAKKREASGFCYVNDIVLAILELLRVHLRVLYIDIDIHHGDGVEEAFYTTDRVMTASFHKFGDFFPGTGDVRDVGMKRGKNYCVNVPLRDGIGDTEFGNIFRPVISHIMDWYRPGAVVLQCGADSLAGDKLGCFNLSMRGHADCVAFMQTFDVPLITLGGGGYTVRNVARTWTYETGLLVGQRLDEDLPFNDYIQYFGPEYKLEVPPTSMDNLNTREYLDNLRTKVIDNLRQLPSAPGVQMQEVPRTTLNPADVEVSDDEDSDLDERISQRLRDAHVQNWDDELSDDEDAHGVSAWEAATSRRLSTVSNGRRKAGIMDPIRPFEHDLGLNYVAQNGAGAAKGKGRTKRTFFAARAAKPVLADLHLDEDDADSDDDDDHRGQALRQSTRSVRSRLLANDAPVVRDATPLSDDMGSPALSTAAPSVRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLR0</accession>
    <name>W3VLR0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLR0"/>
    <dbReference type="HOGENOM" id="CLU_033293_1_0_1"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="371" mass="38630" checksum="8FFA34DC37411C22" modified="2014-03-19" version="1">MVLEATMLVLDNSEWMRNGDYTPTRWEAQADAVSMIFDAKTSSNPESEVGVMTMAGKSPEVLVTLTQDIGKILGALHRSKIVGNADLATGINVASLALKHRQNKNQRQRVIVFVGSPVAQSEGDLVQLGKKLKKNNIAVDIVNFGEDAENEDKLAKFIEAVNSGENSHLLNIPAGPQLLSDIILTSPVLQEEGGDSGAGPSGSGGGSNQFEFGVDPSMDPELAMALRLSLEEEQARQRAAEGTSGSQAPSLPTVSEGTETSAPAAAAAAGLAGTGSMVPRGAESITGEGHNADDESEEAMLQKAIALSQGGGSATNDEDVDMASAEPSAGRRAIVAGQGEGEEDEEMDEDEAIARAIQMSLQEGDGQQDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLS6</accession>
    <name>W3VLS6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03253</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLS6"/>
    <dbReference type="HOGENOM" id="CLU_000524_5_3_1"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="10">
        <location>
            <begin position="61"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="9">
        <location>
            <begin position="209"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="11">
        <location>
            <begin position="467"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="12">
        <location>
            <begin position="567"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="13">
        <location>
            <begin position="651"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="736" mass="83195" checksum="02CD8A40ED670AF1" modified="2014-03-19" version="1">MALPSSLAEMAQATGHLPPHASDDPIAALKAANYMGKGLMDPIKTVEDKWQLVPAFLQVKGLVKQHIDSYNYFVDHDLKNIIKANEKITSDIDPKFYLKYTDITVGEPRRYDGDALQRPITPHECRLRDITYSAHIFVNIEYTRGSKIIRRKNVAIGRIPVMLRSNKCVLANKSEKELAKMSECPLDPGGYFVVKGTEKVILVQEQLSKNRIIVEADSKKGTVSASVTSSTHERKSKSYVLTKHGRIFLKHNSLHEDIPIAIAFKAMGIQADREILQLVAGHDDVYKELFAINLEEAARLGVYTRKQALDFIGARAKASRKPLSMRRPLAEEALDVLATVIMAHVPVERLNFRPKAIYIACMVRRVLMAMQDEKKVDDRDYVGNKRLELAGQLLALLFEDLFKKFNSDLKLNIDKILKKPNRTVEFDAFNQFHFNGDYITSGFVRAISTGNWSLKRFKMERAGVTHVLSRLSYIAALGMMTRISSQFEKTRKVSGPRALQPSQWGMLCPSDTPEGEACGLVKNLALTTHITTDVEEEPIARIAFTLGVEDIHLLTGAELYRPDSFVVYLNGNVLGVTRFPQRFVMQFRRLRRAGRISEFVSVYTNNHHQTVYIASDGGRICRPLIVVDAVTGQPRVTEDHIRQLKSGARRFDDFLQNGLLEYLDVNEENDSNIAIYERDIKPSYTTHLEIEPFTILGAVAGLIPYPQHNQSPRLAYHACIIPLVFCAEQLRFGHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLT5</accession>
    <name>W3VLT5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLT5"/>
    <dbReference type="HOGENOM" id="CLU_096872_4_3_1"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="197" mass="21834" checksum="458E6C25FD9CDC1B" modified="2014-03-19" version="1">MLLQGRGWEQKCPAVLAGLFCYHHHCFAIMTSLEPVEITLEPVFRVTCPVEPAHNVGDSGEGVRKIVPIAPGGTITSPIAALDGAVGMHGGSDYFRTDQFGKTRLDARYFFKLKSGHNLYFQSSGVRFVPSSYPDQTAVQRIMQGELVDPSQYYFRLKLILECDDPDPQVQDLVCKVVIASAVRTTDTVMYQAYVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLV0</accession>
    <name>W3VLV0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLV0"/>
    <dbReference type="HOGENOM" id="CLU_721847_0_0_1"/>
    <dbReference type="OrthoDB" id="2556699at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834675" evidence="3">
        <location>
            <begin position="21"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="365" mass="39524" checksum="80A86985EA37A445" modified="2014-03-19" version="1">MKIALLSLFALILLGVSAQAAPLPAPSVRAPRLRPTKRMPGATSSTLESAEKVLSAIRETGNKEQAIEKSDWKRPVILTIGVAGLMQTVGWNYVAAKSFSDNRKKFLDAKRKAAESKDKPLPKVGDTLCTFETYRTQDEVENRTPSKVQAPCFQIASDATSASPNVTSSTTEDVGKQEGASSGKTGGLTRRGLSSNTVTLGEMVKDTSTSLEHVPPFLSRPSSSSSSSLTELTRLHRPHLGTLEEHARLLSPASRHLSPSNSLVRQRLASLPGFPVLTPVESPTSDSSDRLLRDFSWKSSLDSNSVDEATSTLAPHRWAWIKKARTAPTEDLVFALTILNSIGSIPSLTLTLLNAYYYRGNPRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLX8</accession>
    <name>W3VLX8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLX8"/>
    <dbReference type="HOGENOM" id="CLU_073139_0_0_1"/>
    <dbReference type="OrthoDB" id="2306919at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="329" mass="36463" checksum="764D9AD17F9F0893" modified="2014-03-19" version="1">MDRSLQRLISQLQSDGVPSGGSAPEWLPRLLNNIPGLPAEAVPHKRPNHADLQPLIADAAFHPAIEACLHLINRADRNYPRSLQGDLYSAHFLVRKAQGGSRYLDWLHAILHKLEGDFRNAKMWYTDMGNNNRGALDSLSSAADKESAPPKFVRFHQFWFLPSANGGAGERASAQSVVLDSPADTPRELSLTAHQHTDLVFLASLSASSATKVESIQRNIQKHFRATTKAEDKIRESSSAFSFDELEYLRGRIDTQDLKRDLIGSLTKVELAWLLTRMVEDFGWRSHTAAEAVDALRLESTSAQAESGTERKGKATNMVLDPATGSRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMN8</accession>
    <name>W3VMN8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMN8"/>
    <dbReference type="HOGENOM" id="CLU_031603_2_0_1"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000299">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF40">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833226" description="mannan endo-1,4-beta-mannosidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="39"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="494" mass="55688" checksum="E9DE0FD08B9979C3" modified="2014-03-19" version="1">MKFLQSAATVATALFALARASSHVERSASPAHRGVARHDFIHVDGMRLKDSSGSLHYLTGINYWACMNLAADADAGGSHKRFITELDQMAAAGINHLRIMAGSEGAPTKQPFRMDPPLQPSPGQYNEKIFVGLDRCLAEMEKRGMRATMTLNDQWQWSGGFAQYVSWANGNERYAYPPSWNFTAPPQRSGAPGRGWGNYTTTGSFNEYAAYGNRIYTDRNAERIFKAHISRVVNRRNTVNGRVNKDDPTIMTWQLANEPQPKNQASYLGPYKLQYAPNPSDPLLDWVDRISTYIRSLAPRQLISTGFEGKQGEWYWKAVHRPKNIDYGTAHCWVQNWGVYDMLNSSRANLEAAKAFATEFVGNTSRWANEIRKPVFLEEFGMARDNWQNNVAAGEYQYASKASTNNKDEYYRHIIGLALHSFKSKRGGYVGTSPWAYGGVYRPETQQQNRFGMWWAGDPPHEAPGWYDVYDGDKAVNIITAQKKQADSFIAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMQ8</accession>
    <name>W3VMQ8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMQ8"/>
    <dbReference type="HOGENOM" id="CLU_814308_0_0_1"/>
    <dbReference type="OrthoDB" id="2555979at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="366" mass="38897" checksum="17B4AA6D196E6756" modified="2014-03-19" version="1">MDLDLEKDPLLGSHPTADMSAKTSLNEDHIELRVGDGAASQHRGTAVGMLSRGLKGLAILLIAFLAANGFWALVRPELYGHNGLFSFNGGVNSDHGGRHSHRHHHHHHHEHGPPHGPPHGPPRGPPHGPPHGPPHGPPGGPPGHGPEHPPPPPHGPPSHPHPPPPPPPPGKPGRGPGGDRPGHPFPPPPPPHHPPPPPPPPRGPGKVQECFDLKPGKTLEIRSSLDWFGQSVQVAPSFAGSSVTFVWDGQVGPPGRPRGPHRDLTESKENGEKPKEPKKALGDVVYTVEAPSKKEWEDAGISALELKICTTRRPDATGLDIFNASGIPPSHARIDPAFERIAPLFNTTVQLPSHYARTPIRAGSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMU1</accession>
    <name>W3VMU1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMU1"/>
    <dbReference type="HOGENOM" id="CLU_031567_3_0_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="401"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="605" mass="66703" checksum="CA470B9E955C8F40" modified="2014-03-19" version="1">MRLVSSLGLCVARPTDARPLVWPAASALIGFRAVRAAVRASRASRASGHAQPTLVKLKAKSQKGWKIEPTAARPTWKARQPEKSQLRDPFRLLELTDGSGGAECALGSGRSAVAKSGPVQGPREAQIGRLPPPRAARCKPLRTSGFLHPAVSIRELLFRNQHIAAVKRAYFSQDAHALLAAFRIDPGTFGAIQADLNRDPNRDLSAWILGQILVSASPTDSERFQSLVADFLAYVRDHAPLSYASVASQAPAMADWDRAYDAWALVYSRASAFFSLPDTVWFVSSLRFFASSLVTLAMAVDQRTDAVQKRKTTDAAGRLSKAAGMAGNDRSQARGSETKRAAVLMLANLSFKAYFKLNNTRLCETVLGSVENALKLNRTFAANNGQNDESGEQCYSRADRVTYRYYLGRLRLFQHNIRAASTHLRWAFDNCTLRNLRNKRAILIPLVATYLILGRYPEPALLEASNLSHVYGPLTFCLKSGQAAAAMDELDRHMDWLRFRGLYLILREKLQISLWRNLARRCLALSYGPAQAASAPPTLRVDKLLSAARLAWRDPSLQPSDIEAILASLIDQGFVKGYILHSKGVLVLQKGPHMGFPPIWTVFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN37</accession>
    <name>W3VN37_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN37"/>
    <dbReference type="HOGENOM" id="CLU_1897104_0_0_1"/>
    <dbReference type="OrthoDB" id="10383202at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834713" evidence="1">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="134" mass="14190" checksum="5A79EA503ACC55FC" modified="2014-03-19" version="1">MRASAHPTLLLRLTWLDVDVVAKATSAVLVFTRASALGQQTSAKSFFSPRLAPSRRDGGGRAQATSQCVALRLPCKRESCYTPLLGRVAATVGEDAHGRANALLHERNDKRVPANPFATAPVPALLFAGLSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNV7</accession>
    <name>W3VNV7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNV7"/>
    <dbReference type="HOGENOM" id="CLU_334049_0_0_1"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="695"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="81581" checksum="5811E6FA8538CF4D" modified="2014-03-19" version="1">MSPDQIQAELSRLFCPPLDTTLVAAIAHEPNQTLQSAKEVCETLAAAAVPDTAPASPTRRESPVTKPRAESPAPRTGVSSRRKAFGGKLTNSEHPPSNAASTSSSSKSTSPAASSPPDADIRDAHDPTEVAAVERLLNEWTLVDSASQDPLNLHLTDEEAGSDAEAGRSESTQPRDAFDALSFLQHAFPSRTPTFLRETLDDSHGDVQTAVDTLMTIDLIEAEDALPTPASASAPRSGRGLDYEALAAGLGSHPDDPDAQLRGKKHRAARKRLQHEQRAARAAGKLTVNLTDLRHGTASSNTVLKKLAATPPSHMSRTASPAPQLTDAQLAAQLAAEEEAATRDPDADRPVSDNQWLLTSSVLAQLSTLLDVPSARVTSVYNASSFNLAVCFARLLGLEAEQYPSLASLDEAGGAPSGTAHQIAQGIAVIADVDTDTAAEALRATKGRQDAAIDLLQLHALVQQQVGCADPLDPMRRLQQLGGAEVPKTAEAPAKGYAVDAAANSGKFAASFPTISQAAGSKAPAGSGVYSSVVGRKAAGPTSGAAAALRSGSAIASVLPASSAIVVPADEFADDPVAAERGLAAHTTQYDPMRRMAEYRLVADEYRARRDEALRKAASAWKQRGGVRTGGKGGDGGRGGIAWHYADEARRLDAKARAWSLRASHALVADRRTASIGVVRPGVASTPQNAAQYSIDLHGVNVHEALSIVREHVTKWYASPRTGLNPAPFKIVTGVGRHSPHQIAVLRPAIAKMLDREGWRHDVDHQRGIITVRGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNY7</accession>
    <name>W3VNY7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNY7"/>
    <dbReference type="HOGENOM" id="CLU_132779_0_0_1"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="172" mass="18840" checksum="0E9AB07E5475CEB1" modified="2014-03-19" version="1">MSEQSSSHRYASGDVRDEDDVASWESLSDTSDTSSTSSKPALAKLPTLPDLRFEQSYIATIRGFLHEDSPNSADADTTHGHEHKVKVTRPAPDEHTQLWLGNLRVEWSSVLWVTVRDQLLSPLVQGAVWGVGGILLTQFRQYFSATSRSAGAGGRKATPQSSVMRSLGLSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP24</accession>
    <name>W3VP24_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP24"/>
    <dbReference type="HOGENOM" id="CLU_097772_0_0_1"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="199" mass="22630" checksum="ADF87FB5CBB74A76" modified="2014-03-19" version="1">MWRPCAPTWKRHQHHPRTDRPSLPRSYNMAMPREVAVAIPVVHASSPLNEAVSSGDLRVYLVSSRKHEGRFVLPKGGVEHGESSRQAAVRELWEEAGLIADPSPSNTISRCAPEQLIVDDHKPHKQSPVKHAHEPGFIARARYSAHELVLTNQPAEHWPEAHERTRRTFTLQEAERELEWRKDVHSLFKTWLAGIPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPC2</accession>
    <name>W3VPC2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">37S ribosomal protein mrp10, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPC2"/>
    <dbReference type="HOGENOM" id="CLU_162186_1_0_1"/>
    <dbReference type="OrthoDB" id="2210at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8448" checksum="FF90DC61EE5A89C1" modified="2014-03-19" version="1">MKLNKLKVRPKKDAAAAPCAAEFATMLACWASSNDINNIGACKDSARSLQECMASRKPRGGVSKPTINYHLARLSKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPF5</accession>
    <name>W3VPF5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01717</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPF5"/>
    <dbReference type="HOGENOM" id="CLU_581659_0_0_1"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="146"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="488" mass="54082" checksum="1F311718B370E9E1" modified="2014-03-19" version="1">MAKKAAASGGASNRKPKTAPVFEQDSDGDDGGSLNLDSASELDSDVDASDSSDAAEGNDDVESQNDEEEEQQPKYAQFMDDSDLEAASDDNDDDDDDDHGDSDGSDEEASNDGQAQYSSDEAGSDLDEAALKQQMKQIPFSALMKARRQMNASDSDELSEPDISDLEEDEFAEDRRRLARQTAGKQPARSGKSSSSAADADEALEQKRREVRERLRQLNGNAAGPSSEGDNAWAEARRQREQRRKENERKELAKRANKNAPTEISSKRPVSRRRTVVDTPTAHIRDPRFESLSGSVNKDLFSKSYSFLPDMYKDELSTLKKTLAKLKKQEATQAGPKAKSEHAQAIRDERAKVEAALRRAEGLAGERERRQRESTVKARIKTQNKERVDKGLQPFYPKKSEIKQMLLKDKYDRLAGTGDTEGRRASGQEKKQLKKALERRRRKNAQKEKRDMPVGIGFGPSGSGANGAIPKRKRQAGAPDATNKRSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPL7</accession>
    <name>W3VPL7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPL7"/>
    <dbReference type="HOGENOM" id="CLU_306313_0_0_1"/>
    <dbReference type="OrthoDB" id="2554026at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="586"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="915"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1005" mass="106578" checksum="E48937258A5A667F" modified="2014-03-19" version="1">MVVSRSPPPVRRSPRKDASAALDASFSSFSSHATQPRKIGKLPSARSSAASVVEPATPVHAAAPASSFPSLNQMAAASQERRSASRPADRAAFSASFPANTSNMVPSSLPRPVSRPQMLHSDDDEQDPAHRARGARSSLTNGAIQRARQMAGDETPIAVSQAKAARQAASAARKGTSPLLADESGDSTAQLIPGQRDAAVDPVHADIQVDVPRLPSLDRPVTSISASQPSRSETAPPANAAVDTSSASQASIFGTTNRRNGQDQPIGAANAAVGTAYDFDKYLDSELDPFNRASRANPRRESRPLPAQQQPDDEDEAESSGDTTARGSHLARVRSATAAGTAPAPAPAPIESTPLFSRVKAAATPRLSPHASPSVSSHKLSHLSSLSSGQTASSSTSARQSVLADSSIASNHRFDPSARADRIQTMELGELRKKHAALLRELDATQDALTAAKEESEGWASECTGLQGQLASTKSTHQAAITRESRTRAELQVRLHQYKIEADDRAWKLLGQRRQACLIDVALQHAKNEATYHEGRYHAADADLRGQMDELRIRLMLERKRADLLSLHVRAALRDEARLKKKLAAKSAASLELQAENEKLAELLEEARQSRANDAEAGGEAKSLRKELAEAQAEIVELQKRDDMMTETRKAWKSERKLLLAQIEELNAAPAPAAKSKLAAQAPQPKVSKLIAAAQELPPSSPVYAKKRDRQPMQGASELGPPSEDEVDRHVVATAATRKPKGAKSSSPLVPFAKISATSSTKAALAKKSVKPAKAATNGKSSSSKSWRDEVAITDSSEEDSDDNRQRRRGRGARDDTDSEQDSEDERAKAKASKKKSSASAGKKSATGSSGTRSKPAVVRKNKLAMPIEYDDQTADPSATPIIRSNKRTVDDDSDDERADSSVLGAKFGRDRTNLALPKATSKPAKPSKLVAPAADEGQVKKKKRKLLGGGGAMQWGAAANDAGLAPNFDIPLELSPIKGGAASKAGGGAAFLAGFGMPSRNPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPP9</accession>
    <name>W3VPP9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPP9"/>
    <dbReference type="HOGENOM" id="CLU_069208_0_2_1"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="222" mass="24972" checksum="3F76E70DB3775845" modified="2014-03-19" version="1">MQAVSKFIFGPSQEERVKKVQSQLRSEQRALDREMRQIDQGSTKTKAEIKKLAKKGDVKNAKILAREVVRASKQKNRLAVSKARLNSIHMQLQHQLAMYKVTGSMQKSTEIMKLSNQLVKLPEVSAVMRQMSAEMTKAGIMEELMEDALDSGVLGEDEDEMEEEAQGEVDKVLYQLTDGKLGQASTTDHLPDLAVEDPKINEEQEQQDMQRMQAALDGLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ43</accession>
    <name>W3VQ43_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ43"/>
    <dbReference type="HOGENOM" id="CLU_294419_0_0_1"/>
    <dbReference type="OrthoDB" id="2554259at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="909"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="999" mass="105650" checksum="19D25299FDEA1EB7" modified="2014-03-19" version="1">MIFEGIGIDLHFLFEGHSNSREVAEIFQQYHHAGQRVVPERSTRLGLFRIQETSRVVTDYGQQPMGNSRVDALTFQVTHGSKARHNLVRVWRHSDEEPPVADASKCDFVTFRAISRENGTGEARVICEAQPIEFSYRHTSLWIDAGFVNEVPECDIEVLVERPALKQNVTVRFVYQSQDDASMVTPFPGVPLSDDGLSYRDDASNIAVGSQAERQLRQFIDAFISRRNLASYGFRIAEDSNNIDGHEDARHAGSISAPATQTCMTSSAAGLLTPDLSGPGLPRRAGSMNPENAPDHAVAQSAAGRSSRDFQLPGDASFVAPTSPRGWTGAWSRITSIANHISPTRAASLPPAAPSAQTASDPFQPVPAPAPPHEEAVMEGSANEGRVQDSLDGNNAQTIDSQSMDVGGQSIRHGLEQLLDGIDSILGDALENMNSHGTIDGCGLPAPSGVVGDATAASNDMDVGSSTTAEQMPAAQGDKAARTIGDGSAPEHQDAMSDATPEQAAAHALLVISDSLEGQSAATDRPAVSTAQDVDMEDGEAASNDNRPDTHGNAPAVGVIQAENNVNMADATQDDFTIVSCTRRTDAQAGGAAPSTAAMPADNESLAGSEVPLASRTGLLTVEALQAIQELALVPSRAGSARGPPSDASGSITLRRHGRHSRSPALSTSSRSHRGFNPTTERLGQIYEYLVAKVMQDESQDSAKCNAIAEKRNQKESELEAARLRILVEKERYKAQYDVAHKELDLKRDTMRLLRAQYKGQAGFSRFLAKIGVGSRAGSDRRSRSRSRETTPRAITSRAASRQATPTVVRATPKPEPIDLTGGDDLHAGSGARAGRRAASIARSLGGTLASQQTQSVIKVGDVSDLMQPSPVEPKRGGSVVAGTSGSQHRSKHVGGVGNQIGEWRHSVPASPRTSRAPTPAAASQASTSRGPSGSIDDPIDLSGSRRPARSNGTIVLDSGSRRAASSRASSIVPPDAPLFSPARSVRESSAATGITTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ69</accession>
    <name>W3VQ69_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ69"/>
    <dbReference type="HOGENOM" id="CLU_428347_0_0_1"/>
    <dbReference type="OrthoDB" id="2547656at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="639" mass="66736" checksum="872D7F5AAFDCB2F7" modified="2014-03-19" version="1">MPLQDANRAGYRRMLAEQRRQRGAYDPARLAQISSRHAARRTRLGRAGRSSSKPAGGMRMIKRDDTALAEQDVLNAVIDAAKPSEDVELPPAPAVPGAAPDPILPSAPDHSGAESDPNLPPAPDHSGAPPPVNSLPSAPAHTGAKVATPPHPSTAPVGQGSTPSLPPPANVSFNGTTPVDAQASSGAGPADPSAGGDRSHHTMVAVVSSVIVIATVLVGVMWLLRRYRRRRTSETEEKNSCQLTSKSQRLHSLDGRPDAHAYASAVKTPVPYAAHTDSNETLVNITPPSAALTYEKPMSHAIAPGSNGVASAAGQRGLESGRVAMPTIVAPRPLDSIAEVHEIHTGTSTHFEMCTRGRDGLLSPDTPRRQLSPTRSCADDKTRPLTAPSTTGFGKPAISGSSSLDHDAQGARNTTAGGGLLALSRPHSSKGRPTSSKGREIEMTRKGSQLVIRDRPSTATLRPMSKAGTTFRSALRRNAADDDADGAIYIETDGIVGPTSRDSVYLEAPAARRGELSVPVSAVSRREGGLPSRFSNSTMHTARRTSCATTVSPTGSFSFEIKDAVRQSAPLTIQPGAPPSPTDTVRGAAAHRQANEDQGPETGGSLGEGFVQELDWNVHSASLAVDGYPPFGAMHSTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ75</accession>
    <name>W3VQ75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ75"/>
    <dbReference type="HOGENOM" id="CLU_032067_2_0_1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000228">
        <property type="entry name" value="FAD-containing monooxygenase EthA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54875" checksum="107ABE44AFFF90B4" modified="2014-03-19" version="1">MGSINYDSSDVLDFLIVGAGISGINAAYRIKDELPDKKYAILEGRENLGGTWDLFKYPGIRSDSDLHTFGYAFKEWTGADIAEGKEIVAYLNKVADENGITPNIHFKTTVTNADWSTEQRCWFVTAEQNGEQKQFRSRFLYTCTGYYDYHAALEADIPGIKNFKGKVVHPQFWNVTEDDYRGKRVAVIGSGATAITLIPSMADVAKDVTLVQRSPTYIVSLDKYDPIAKVMRAVMPRRMAAFLIRQKNILRIYASYHIFRTFPGVAKRILRTMAKAQLPKDIPLDPHFKPSYNPWDQRLCICPDGDFYTTLREGKAHIATGHIDQVTSNEIILKNGERIPCDLIVTATGLKLHIGGHIQTSVDKKPVKANELFVWKGCMMESLPNYAISIGYTNASWTLGSDCTAQYVVRLVKHMDKYHKSMAVPKPSNRDQLTEGPLLNLTSTYVKKAENELPKAATTGPWRMRTNYWYDLVQAKYGGYDDIVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQD2</accession>
    <name>W3VQD2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQD2"/>
    <dbReference type="HOGENOM" id="CLU_023194_19_2_1"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="5">
        <location>
            <begin position="160"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="46496" checksum="DD21D5E5AE44B9CD" modified="2014-03-19" version="1">MSSTTAATPIPVCVVGFGNSARTFHLPFVQALPQLFTLHSIQQRPRTAANSSSPDAAKLFPGVTIIPDFDSVLTTLPKNGLIIVTTTNDTHFPFAKRALEAGFNVLVEKPVATNEKDVQTLIDLQNKTGKLCAVYQNRRFDGDFLTIQSLLSDKGAEPSALGVPTYFESRFDRFRPYAKGGWREEVDPDTQGGGMLWDLGSHLIDQALFLFGPPESVTGFVRNQRNQGPAAVDDDWLAILNYPSTAPLPPSSPASGSKIGGLRVSLGATCLSSHVDAEQPRLRVEGTRGAYEKRGTDPQENQLKAGWTPSSHPDEFGVYSEQDPDTVRLGRLTTMVRSDEDLSLPAPGSGGAAPKQPTLSVATIPTLPGRYIDLFANIAATINAAQHAEAQGASVAEAVSSVSLVGVERTLNAVKLIRLIRQSSIEGKTLHWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQF9</accession>
    <name>W3VQF9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQF9"/>
    <dbReference type="HOGENOM" id="CLU_023111_1_0_1"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50439" checksum="9F06F3AD59C62D37" modified="2014-03-19" version="1">MSSPVTGVVVLIRHGDRQGFYQSPSTYTASKTNLTVLGYLQELNSGAQLRTRYLDTASPLVIQGVNTNVAENVQISVQADAGGEGGVIVESANAFMQGLFPPFNETLELANGTTVAWDNRAQLIPVETIEPDQSFVMEPWTDCDKFDDWTSTFYSSADFKSKSELAQHFYDSLPASLIGNRPKTLVNAWNVFDFLNVERIHNATLAPMITDDIAQQALFWANYHEAGLFSSPDPMSIGSIAGRGILNPLTDSIRRVANASDPLKVSVLAASYKPFFSLFSLFQMLDLQGKLVDYASAMVFEIHQDKTMQIYFRNGPNGSLDAHNVLDSASLPVETFLQHYDPVKLDTLAEWCNLCGETTARGCAALNALNGTGSGGKYSDVTSTTGKHEVSPVVAGVIGALVSLALAAVVVAALSYLMGLTVIKRSKGAYPRRQHLLAPASSSTVHRQGNSVELHSNLDHKDSHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQM0</accession>
    <name>W3VQM0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQM0"/>
    <dbReference type="HOGENOM" id="CLU_017452_2_1_1"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="120"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="6">
        <location>
            <begin position="214"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="838" mass="93838" checksum="49FE5A384B8A98F8" modified="2014-03-19" version="1">MAAKAARPPRSSWPTLLVKPRLSIAAGRPVPLATPQDRSGDGHARRPTSQPSKAFVPPSHHVSRLQRIHRDLLRLDHPRTQLLTGLHTRMAPTAVSPRAPPAQIAKKIERSSKAAGSKAEQVKFATFDVTDQVFYRSADKSCYAIVNLKPIVPGHILVVPTEPYHRLSQVPPQVIASLFQSVQEISRGLEKVFEADAVTVSVQDGEAAGQTVPHLHVHVLPRKQGDITPNDLVYEHLEQWGFDTAKLLKQSDNAESKFKVDADEDRKPRSKEAMRQEATFLGSIFTADGKFDASRVDGVRSTAAKRAATTAAPVQQKRQRMDRLPVTLLSGFLGAGKTTLLEHILTSRDHGLRVAVVVNDMGALNIDASLLSNHRVTQAEEKVVQMQNGCICCTLRGDLLEEVAALAANREIDYLVIESTGISEPMQVAETFSEEFADMYVQMADDLEAEMRTSPQASTENQKVAEILKQGGLPAVARLDTCVTVVDAVNLFNDFNTTEFLVDRHKDDHEVPEEDDRNISDLQTDQLEFADVILINKCDLVREEEVERIRAFVRLLNPEAKIIATTKSRVDLEQILNTGLFSYEKAALGAGWLKSLNEEIKPETDEYGIGSFVYRARRPFHTARLWQTIREVFVVIQTEYIDDGEDNDDEDDAQSDSESEAQSEGDDDEEEAQPQLNPQARLQAKNASETFAPLLRSKGFVWLATRPIMFGEWSQAGIMLTLQGGARWRCELGEEMWPQEPEIVEAIKRDFQEPWGDRRQEIVMIGKDMRHGAEQMLRTALDACLLTDDEMQQWSAVMNDPKLASINEKQEALQQLFEDGFEDWMDHEDPDAHEGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQT5</accession>
    <name>W3VQT5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQT5"/>
    <dbReference type="HOGENOM" id="CLU_654031_0_0_1"/>
    <dbReference type="OrthoDB" id="429183at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483:SF1">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45110" checksum="3CE192FB2922490B" modified="2014-03-19" version="1">MPIFGSFVDLTFSNSLDTSTRGVGRLGVQRATPARVPEPLDPAFRLYPSTIHPNRRSLFPDLNPAAAAQAGPPLPTPHYNGYNDLPASLSTTSSSSTYKGRQRAHIADPIVASGGAPYAQASSIPAGPVRRTAAAPAHTKNVFSVSTQRWAKRLADMAAPSAPAGAGGNGAGAPREVSIGVGTVYDSNAFGSNPYARVASDDAAPAPSRSHYFLSRDEILKGVANRFVHSSAYLWFYAGMALASLLTVIISLTSDCPGTLFYGLELAINLLLIAEVGIRLVAFGKQFWKSTYNVVDLGLVLLCAITLLVIFFHHECSPFRRTPSYPDDDGERRGGRSGKGEELLDSILLIGRNVVQALRLVSIVRRSGSNVTSRPTRIEIGNRPYSLDLDLEDEGAMARDRIRIGEEERAPLFDADDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQV8</accession>
    <name>W3VQV8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQV8"/>
    <dbReference type="HOGENOM" id="CLU_007709_0_0_1"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="581"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="953" mass="100810" checksum="EED6F23E417873F1" modified="2014-03-19" version="1">MSPPASVTITQLEPVIFLRGQSSSGEDARGRRRPVDFDAPPSQLRALVTLHLPKPSKIKEISISLKGTARTDWPEGIGPNRVEMVEEMTIFQHSISLFNAKDANDSVPRARPRSNSVGPGIGLQEDVDWDYAAAAASARTSARQPSASVPRPINTTGRRDEEGSRSPGSQGQSSSNLARQIALGAAKAGSAIIPPTLRPDLSHMKLRDSPTSPSHLRPPARPPLHRTGSGTTSWTSEQTSPDLESTSPRLSPTANFSGSWTRGGAPTNGSATSPQDMSRWHDYFESQGYERPPLYAPRSAPLQGYDSWPTELPSDASAAAPQVAGPDSQATSLLGSVSSSAAPSTSTTPLDRSAANSAQGLARLNAALTAVAQPRSKPTAAAQSASPPSAAPGRSILHTQSPSVPRSKEQTVRFDPQSRVDNAAAAAASNASNNKSSGTRSNPSSRRSSMELDKNSLKGKLSSKSGHDAKGKKPGLKNLINGLLKEPAADSKTPNEEPALSDSKEFKKGTYTYPISISLPSNLPPTLHADFGFNRYILRAHVVRSGALTPNLVAEREVTLIHAPDEDALEETDAIVVERCWEDLLSYMVVFSGKSFPVGQKIPLWLKFVPLGKVKIYRILATLEERTDYFAKGRRVARHEVPRKWTLLKIGHTSSAEPILPVVSDSADALDKSPLAPLARAAANEDEDSDALASILDPTGPWELATELPIPAGASTRINLSTNHSKSNIAVHHLVRLSIRVGRSQGEWQVWSDGAANSSSSAKPAPQLYDIIIEAPITLNHSHTASEWTALPNYWSLPAEPEDADSARASPEREAAPTRPALPLPVLTSRTGLVGQSHGATPSRAGPGGESSPTGSPPMSRNPTQLSRRWLALSADQNARDGSAPAGSNGGSAPPPAYQANARTGERTVASTSMSRSPSTADNSEATVRDASGPPASTSTANADGAYQVGMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR38</accession>
    <name>W3VR38_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01363</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR38"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="127"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="328"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="531" mass="58617" checksum="BFBEE26283F39A2A" modified="2014-03-19" version="1">MMEAKKVMAAPTNTDLDVAIAHALTFNTTISALSYHHPSGVSIIQWPRSPCPSALASSAAEATDTSIARPLGEPRIAMPRELITLQAGQCGNQIGSHFWEHLCREHGIAKDGTLEEYAAEQQGGDRKDVFFYQADDEHYIPRAILVDLEPRVINNILSGPYKNLYNPENIYSSKTGGGAGNNWAQGYAAGEKIADELIEMVDREADGSDSLEGFMLMHSIAGGTGSGLGSFLLERLNDAYPKKLIQTYSVFPNSEETSDVVVQPYNSLLSMKRLTNNADSVIVLDNAALSRIAADRLHLQNPSYSQTNQLVATVMGASTTTLRFPGYMNNDLVGMIASLIPTPRAHFLMTSYTPFTSDNVERGKATMKTTVLDVMRRLLQPKNRMVSTLGASKSSCYISILNIIQGEVDPRDVHKSLLRIRERHLASFIPWGPASIQVALSKRSPYVPSSHRVSGLMLANHTGIASLFRRMVDQYDRLRKRSAFLEMYKREPMFANDLSEFDEARETVAELMAEYKAAESPDYITGQPDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR93</accession>
    <name>W3VR93_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="3">SDH assembly factor 2</shortName>
            <shortName evidence="3">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR93"/>
    <dbReference type="HOGENOM" id="CLU_103054_0_0_1"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="235" mass="26198" checksum="A42F3C192029098A" modified="2014-03-19" version="1">MMIRSITGSLRRTVAAPLVQPARMARMGAARALSTSSPLLSSSRPDVPNPSQTDQGSTGPGQSQPASGPSGTVPDRTLSDPYPLPFSPDIVDLNNADSGPESGPQSKWAGVNLASDRQTLDDVDAPMRVPGRETEDRTTKIARLVYQCRKRGTLETDLLLSTFAKKELNNLPNEELDEFDRLLDEPDWDIFYWCTLRKPIPERWHNSFHTEGKLGHRLIQHTKNEEKAVRWMPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRD7</accession>
    <name>W3VRD7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003027_0_0_1"/>
    <dbReference type="OrthoDB" id="10261361at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="846"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="927"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="964"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1619"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1738" mass="194315" checksum="7F0A4DD8E9FC0DC9" modified="2014-03-19" version="1">MAPPQSTQTTRSPPRPSSVSLRAPRSASVQQLVSRWETQPEPTATSTASASSAASASSSSPLLRANAVIATNGTLGPLDWTPKYGLPAPLTRVSTKITASDPQDPSADQQQHRSSRPRIPPASPRGRHVMPLRSVHPVPTIPSPSSPCSPPIHTLPEPSPPCASRTPSSPPSTLDSATSKHTSKPPSTIPASDRAKFAPPSSLASQAQSKVVPAPSTTRSSQDAQSRVRDFSPRDTNIDRHDGLGNASHTQGIFDLDAKVPLGTGRFLPSSFRRNLPDQAASIPERSSSHLSAPQPTHEQWSPEEASSIPLLPSAHAADSEAYSSKTRGQAAQWRQLVSEELAQNAVCSNVDAQRLPISADEVFKRDAPPIDLPALEEYLRNPIIFGDPGFTPSDQVCTDQEKLLFGLDGAVLTQSLSSPVKPSYLHSSIGPASPSKKSRFSSKSAHLEVAGGQISCPAVLYSSSVDSDVSGSSKKKSDLRQRRKAAQTKQLPAHDEPQTRKGLADHHKDADDDSDPLLEEVAWQHKGDLGAHQRAGQETLNPFEDIHQVPSPDFDDDATLIAQDSFDAEQVVSRISARLTESQQTGARKDAPSSKFSTSSHPITRKHMFPPLMLLKENNLDELKSNAIGPRKPPGGLWAVGWLGIIFDMVIGVEGSTFAAGILRLETLRDLFQIMTIQLHFQRYFDSSDPTSTSSKVFKFMLQTLPAFLGFDLVSVFGYAVIFFVIWISITALALWRFWHMTKAHNPNKTVEGFDSQGWVYKSASRGTRFANTCLVFVLGLLYLPLSKLAVDALVWSSDFWPVPNPYKGGVDHPDPGPLLGDPDIWRAPLDFCYTTTMRKDAFNWAYVVIPLAVLTILFYTLWYPYKLMMTIREMLPRVSAYNELGRKRSNEEMQIYYQRLLNRDKSPFNFLYNSYHRKWGYYKPLYILLFKLTNLLIIGVLAKDNCLFRNVRTRTMLVAQQVTLIVVMAALLGIHLLIKPFVDKIGNRSEMVSRIGYVLTATIGLLVALNVQGSTVYNTTILYIVQAFTYGGNIYFALIGMSFVAHQVKRWQSRVDYTIDLFSPVLDMTKHIKRRVWQETLSIIILCAPEYHMPLEQVIAFSVSDDERWPPYLIDFRGSVAERHIENLKIVKQIGIDAYRREIDFSRTAEGAHRQKLLRTIQSDYAGPDVHWRPPSPPFPSGVMSFFGKAFVVPFPPTLVMCYDEGTAASVVLTKIDELEAFIAQNSDSRVQSKRRVRQALRALEGQRVLCPHVENVQVGDATSGMVFVDKLFGRISRRRRALPRFGMRTDAHVQTEYVLATPVSYVEGTLKIERRNEFDWAGYNFDGGFEVSIVFDEGRTKDSSGALSVVRRLLQVSASRAFGLTEDFSMNASLSRFLQDNERVVVSRAPLVEKMLRKYRRDFEREARWKERVLPYSFLVDVFDNDGLSPLGLRMALVETGCARSMRNLPVLYEGCVTLMYERLAAINRSPVHRFWWMLFDELWRLNSADYAQLRKHRTSFSPQYPLSIAYRPLPRAELERFLAQRGLWHKNGAKGGPFNRGMLNRIYFYLNEIVFAGHHDGRVLNPRRGWSHPDAGSPNPFLDPVSSDLRRVATIKVGLGHDATHATRRGISTVDDTFDSSGDSGGHAAGDRSWGMTANASVPSQYTGGGTAYSTASVVVRTAYRWEQRLDGVATHTRWQRTRLRALQWLSLHPVELKLQREKLFLYLKLVDTPTGQRYELLRPSCRRTDDDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRE4</accession>
    <name>W3VRE4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRE4"/>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="55"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="566" mass="62184" checksum="C5557D80F9C4F942" modified="2014-03-19" version="1">MAHSDQISSEGPYAQEKASSSDDAVKGYNQEVSSAADNQRPEERQLHRALKSRQISMIAIGGALGTGLIIGTGSGLANGGPASILISYSVMGLCCAAVMAALGEMSTYMPHPRGFAGHATRFVSDEFGVATGWNYLFKYLVVTANNVNAAALVVSYWTDLSGGIWIAIVTVLIIALNFGGPKWFGEVEFWLSLVKIITMTGLIILLLVIDLGGSPTGDRIGFRYFQDGLAFRPYPRTSGDKGRFLGFWSTMVTALFAYTGSELVAVTVGEAANPRKSVPSAIKKTFFRIVFFYVVGALLVGMVVPSNAPELLAANKKGTSAAASPFVVAIVRARIRVLPDIINAAILIFCISAANSDQYIAARTLYGLAIDGKAPAIFRRVDRRGVPYVALSVTALFCALAFINLASGGPQTFSYLVASVTMFGGLTWICILIAHIRFMKAMKAQGMDRNSLPWKSPLQPYLSYFAVVFTSIVVFFKGWNSFLFTFNWRTFLTNYIGLPIFFLIMIGWKLWHRTEFIRPEEVDLVSDVREFDEQDELVWKQDEEKNNAMMQGAPIYKKVWIYAKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRM5</accession>
    <name>W3VRM5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRM5"/>
    <dbReference type="HOGENOM" id="CLU_335900_0_0_1"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833328" description="TM7S3/TM198-like domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="134"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="620"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="698"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="788"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="800"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="983" mass="104121" checksum="569B8987C288E77C" modified="2014-03-19" version="1">MRFTSLASVAIALALISLPASRAQQASSTSSVSGSSPTGAPTASASPTPANTTVLSTITTTLSSGQSLPTSLTASASSNGSVWYIPVSTVVPVSQNATSTISSAASATSSASIKAANTSLPLDTIIDPAFGVLGVILIGAGLPMGFYGHRNRWSSYFLSGFFALALICISIILKVGVEPAINPPSKAIRGLFLVAAVIAGAVGGIISIVFWRGAGLLACGLGGFFFGLFIQAVRPGGLIRPIGLRFILYIGLYALFFTVSCIERVHSLMLALATAIIGATAVTLGIDCFSTQGLKEFYVRNLGFDALFSNKYPPVFQNGHFPLVQGMQIELGVLGALILMGFAFQMRLWSDLRTQLAVLKRSDEKRNLRSKAERAARAVARTAKRDLAEWEARHGYKKTATGNPASRDEEMALPAASTPDLKDARSRTSSFMTLLRSNTDNTQLATPTSHMEKLADSPGASSTLDNVAFPFPAQSAGRRSSQFLEYIQRGPERVEPEGPLQLDLSTIGAPLGDMQPPAESFPMSPMSSAPRPGAHTPQPPKSLDMARATSPDPAGGPDSFRRRSASTAALMENNASFLDPVPPRLDLENSAGRPTVDSNRTMSSTSSTFAVDAARILPSAQPNRSASAMSGPELGPTAASAAALHERTFSDPSAPSGPGLASMTPMAKSHSHQGQLQPHTAALYVDPHAGHYTAEMQRQSPLASPTYSPSVPASKMISGGQSHAVTQARQSLAKRRSDQPMVPWTNPGATGQGGSAHKRAASADSQPRVRAMSIEELEARHRAKLAALQAPATQTVQEADALRRAKEDWERKQKLERRRMQEREAHKHAAAAAAGDGLVSPSHSRIGSPDLQRPVSGSSRDERRRSRALSATLLEAVGEESRDSAGISRAAEWRKSVSGMDQLDPRAARPSNPPTPSSTRPTSPQPNAGPERSTANPFPAQAAQQRKRLSETDRRRLSQGAGDRSQRRHSQPLLDFNLPRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRR6</accession>
    <name>W3VRR6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRR6"/>
    <dbReference type="HOGENOM" id="CLU_061463_5_3_1"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="260" mass="27552" checksum="849C1F20D406E7E3" modified="2014-03-19" version="1">MNALKTSLSAITNATFKGKAKQVSPLLSSAVAGRSLNTSASSSPPSAAAATASSSASGSALSAESAVASNERALALLKTQPNHYAVASITGRTYLVSKGDLVTVPRLKDVQVGDVLVLDKVHEIGSRDYTLRAQDTLNTRRISSAVDLASTTPGTLRGVSPAVVPQARRLLTRLATPESRSQLLPLANTWSSRLIPNGLAHIGASLPQSTVKITAVVTENTKGALEKILKKKRRKGYKKTVQHKQPYTRIRIEDIQIQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRT0</accession>
    <name>W3VRT0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRT0"/>
    <dbReference type="HOGENOM" id="CLU_293721_0_0_1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000062">
        <property type="entry name" value="Related to gata transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="598"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="677"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="634"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="723"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="837"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1002"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="785"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="861"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1037" mass="107911" checksum="D64F944FBA36CA2F" modified="2014-03-19" version="1">MAPLLLKVKGNKSFSPFSNLHDEDSLLRTWRVCTKVAAHLEQGQRLENLSWRLWYLHDLMVENDDVKSRRDFKKLSKSTGEKLDRDRGRAIGELTAPPFRKTDSGEALRKKAVERQKLRALAVAKLQGKFRSSVGGSKQSMKDMQYTFALDPTVNFKQTTVGNKDASREYAHNQRQNAPVGTTNKFPLNLSPPASNTDAARSDAMELSTDHPLAFGAVDSGATFDQIMASAGMSNLGTASAGYRIEDIEAAERELLLNHHIDLNAPLDSLLAGLGGMEDVQMDLADLGLPVGDLPNFNAPFDHSFADLSSVQGFASGAAAPSSGPSRQSVGPVKLKQNRRKKTDPQPQKVASELARKKAEELRTMRKLSEQTQRTHIQNSSRPESKEPSPDASVGSVWGSQPDWLSTNNSMGTADKATALSQSLPEGAHLPLSAYGSVANAQNPMGGLHIDTSVSTIHGGHPQPSLFGARGTSVSVPTTPLLAPEAGPFQGADRPVDSLSAPSSPTMRPSLGHIGRSGSSPGPSTSAGTSRAVKRHSTDGALTSSDGMPKPKPRGRKSIAGSIAFTAINPELNRKPDALPPGSSTPSIATNAQPTQAQCTNCGATSTPLWRRDPNDLLLCNACGLYLKLHKTPRPKSLKSHHSHSHAGHMTPSATPGGASAPGSRAGSPSREGEAGADDMMSCYNCGTYTTPLWRKDDAGHTVCNACGLYLKLHNEHRPVTMRADVIKKRSRYDEKRGRASTASSRRTSPQPQAEASAVAGVQEPMAVDKPARAKSNSVTFQLQPSEAKAAAGTSASAPGSADVPGPSWPSLGNEGNVAHQLNDAFATAVNRFSTGVPAPGADAGDAPAPAPAPAPGPAPGWGAWAQQQAASGPPSMSGSNGTPTSSASATSPPVPGGPSQTDIQTLSAAFSAHPALAYAVHQAAEKFPAFFAQNPLGATASVAAAAGIHNPFAASAGFAQNEASAPVTGATAVEDAAIDVAGVGTPSNLAGHDSVMLDLATPGAERGGGSGPGGREADFGRMLGADGGTPQAGSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRT7</accession>
    <name>W3VRT7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRT7"/>
    <dbReference type="HOGENOM" id="CLU_097408_1_2_1"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="60"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="164" mass="17610" checksum="8E4C7887EB27EA93" modified="2014-03-19" version="1">MIAALRPSVSLLGRSAVRAAPKPFAAPMRAGFASSVRAWGVQKRFTEEHEWVSFDDATNIGTVGITDYAQKSLGDVVFIELPEAGAQVKKGDDIGAVESVKAASDIYAPVSGQIEAVNSKLNDEPSLLNKQPEGEGWLCQIKLTNPADFETLLTAEAYQKICEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRW1</accession>
    <name>W3VRW1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">NADH-cytochrome b5 reductase 1</fullName>
            <ecNumber evidence="5">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Microsomal cytochrome b reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PaG_01113</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRW1"/>
    <dbReference type="HOGENOM" id="CLU_003827_0_1_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20" id="KW-0274">FAD</keyword>
    <keyword evidence="7 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="214"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ETS64274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="458" mass="51133" checksum="67DBE4E2F7446B17" modified="2014-03-19" version="1">MAEKELKEISKAELAKHNTKEDLWFIIHNKVYDVTKYQTEHPGGIEVLMQLAADDASEMFEATGHSDEARKKLDKLIVGQLPSEDREDDVEVFHKVYPDTHNPDLKPLGKESYALFLGLTGMVAYCTSKVSSRYHLGQRFRHLLSQPFNQGVLIAFVVSGGIGGYVLFKSIKYLIPQSHPKGGPTYRPDDQPHVARKTHAVPKRSRDVCPLSKTESKKLLLQDKQQLSHDTWQFTFALPRTDRTLAIPVGAHVVIEAEIKGKKVTRSYTPASSPTTVGTFDLAVKVYPDGKMGTWLRSLTPGKDSVALRGPKGSMDYHRGWAKSILMIAGGSGITPMFQLLLSICEDEKDETKIVLLFANKTEEDILLKDQLNALADKNKQLEIIHVLSDPDESWEGPKGFITKDIIRPHVSDPSDKENRVLLCGPPPMVDAMKKATVELGYDTAKPISTMKDQTFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS11</accession>
    <name>W3VS11_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS11"/>
    <dbReference type="HOGENOM" id="CLU_280472_0_0_1"/>
    <dbReference type="OrthoDB" id="2413468at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1120" mass="116311" checksum="A3B375344C178C97" modified="2014-03-19" version="1">MSQSQPINPDAGSSATLDTRSRANTCASLSAAPLGTSYRSTTGSSVVSNGSLLDLYARSPGSFPSSAETPSHISASSTIGNASIPMQASASTSSSNGIPAVSATRGFQAPGNDAVPASTGFSMVPSDSNASIWTTASASATESLPHSKRASVAGFDVDVMRSIQPALNADTLDAARTNDLPMPPRIGVEAPQDDSDGSHYDDEEVLNTSTHDSFDRSADRTIEPPHTSHPATAADDEEEVFSNALPSPPVPRRTSSVAQDAFTISPSPSQTENLNQQDGTLSRHTASRSRSGSGQLGSSQIPQRRSSADHRDDSLHQLLQSDDTGPTPPTQEASSSSNAPRDTSSPTKRNLLGAVNEHTRLSTDGSRSSHEPTEDEQQRLEKELLAEADDSRPRTLKEARERAKMRRQQSDTVSPLAGGPTSGSTTTSPRKGASLHVRDVASSVVGGAIDEEVARSSIDSRDRPVRNPKRLSNRDRTGAADQRSLSERSAPSDYSHDSDGEGAFSFDPPPQAAGNTTASAGLPTQGSGMDDLTAAVSNAMNDLSFGSADETISADEEQATPMPPQTQTAARQVMPASLPSARSLAGVTGISVAQAGVRSSPLASPAKHAPPTPRTPQTPSGSSYFPAANSAQSLSMAPLSSPRAAPTTPTAAARPVAPALPSRIEVYGKTLPMPAAFASSNIVVGQKRGSSWDRARAYAQCTNELLHLQTGLALWMQVVQRPAMRQQARTGQSQPDWLAQGTLPRSTHVRNEGSYADSVRSDMTFPMRGDGAKAKEIVSVMPTMAESPVQTPVNLPYPGVAPQQTRSNSTQSFASLPGSTSVGEGMGAMRTSGSGAGNRFFSGLGRKNSKRQASVPPPAAVPASSPLASAAIGTGGSRAYLANSRNRQAQGSPIVSGATSSANPSTDTFETTFSRPESPARAGLGMRGVEAEPSARLDSVREGASAPSGPRPLGPRAPTGSTRLSYEMSRTNSGQAVTSPITPITPITPIAGGFGSGPTFVSRLSGGPSSHEGYTSDLLSAPRRSSQAGSTSPSLSAETSPRIGAGLRSSLSYGSVRDRMRRGSNSGDSEAFNATLTKLADILPDADTETLALYLRKAKGNDLQAIGDYLQDQSLGKLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS23</accession>
    <name>W3VS23_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS23"/>
    <dbReference type="HOGENOM" id="CLU_021713_3_1_1"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="660" mass="73713" checksum="E13C6D045B067184" modified="2014-03-19" version="1">MFLDENGSRSRQRSSRPAASVFGRQGEAARRARDWARAALLALALCTDQAENWLANHSPESPSTNAARIPFHHLHREKNIVLGSACRTFAIVTNEQRHAKTRVRYFQTSILGTSIATRPSPTATLLLLRPQPPIRSIYVLSASENTPSEQRSASIRTHPHLDPKHACESDRNDTLLILSAPAPDSDNALLLATKEGDPSGGWRFAQCFGDKGEVEEITEADIISTVEFDHTGDYLATGDKGGRVVLFERNDSKKGCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNAAHFLLSTNDKTIKLWKVFEKTLKLVAENNHNGTEYGQMRDPDVHPSLLPIPKPVVGSGIGLRLPRLTPVDTIIAAVPRKIFANAHAYHINSVSVNSDGETYISADDLRINLWNLNISDQSFNIVDIKPVNMEELTEVITAAEFHPIHCNQFVYSSSKGTIKLADMRDSALCDAHAKQFEEEEDPSTKSFFSEIISSISDVKFSRDGRYILSRDYLTLKIWDVNMDNKPVKTIPIHDHLRSKLCDLYENDCIFDKFEALWGPDGKKVLTGSYNNYFHVFDKDDSSDVVLQADKSAFKAKRMAGAGKKGNKGANSTLGAPGQVNLDNPDFNKKILHASFHPRENTIAIAATNNLFIFSANNPAGIPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT11</accession>
    <name>W3VT11_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="604"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="1078"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1293" mass="142134" checksum="0325275866A26035" modified="2014-03-19" version="1">MHPSPHLFSTGLRLLAAAPTYALQDPNELAIQSIPSYTFRAGAFSVRLPVIPRCEAAVRSVPVPAQPSEEREAACYPLPVLHHALARNRSGQPAPPKQRGPGPNFTEENLSEISPVPSSRLNGDSLASPRLTSPRIAVPRKLARSLQHAAATAATLCPADPVPHISAIRRLVSRPVSPAAASSRRGGKDSSSSQREKKNLAEQPGTDACTAGVVEPPPPAAIPEPYIEARLRAIRSLSPHHPPQDHPFPPSYIDLLEMRSIKAASLTPLLAGLLATLSSTAALPSSVWEHQLETNILQARADSNGSTIAPSFDVTKCPGYQIVGDPKQSQHGFTAQLALAGEACNAYGVDIANLTLSVVYEKKHQLHVHVYDSDKQQYQLPNGLIFDRPSDSPDEVQDASTADDSDLVFHHTAENGTQAEGSAWAFWIARKDSGDVIFDTRPNNIPTYDSGINNVSADTKRNSTAMPKHEMVFENQYLQLSSALPEGANIYGLGEYVTGSFRRDPDETLQPFFTLDAGTPVDSNMYGYHPIYTEARRGSDGKLRTHSVYLQNTAGMDVLLRKGVIQYRAIGGTLDFRFFSGDSTEGKNSPNTAIQQYVNFIGNPVMHPYWSYGFHLCRWGYNNVSDTQKIVDAMREADIPLEVQWNDIDYMQNFRDFTTDPERFPKDEFAAMIKGLRDNHQHYIPIIDMAIPKAPTNDSDTFYPGTRGDELDVFVKNRNGTEYIGEVWPGYTSFVDQQAQNAAKWWTEAIRNFSEIVDFSGIWLDMNEPSSFVIGNAAGAETNLSDTPAYTAATSVTGWPQGYNNLTWGNSGNITVNGTYTFQQGPVQNNDAMQRRAVVVSREHDVITKRAEGGGKYGPNDPDYQYANASQRYLSNPPYAIHNGIHSSEMPLNVNLDKKTIAMDAVGVDGQRAFYDVHNLDGTLEEQHFYNALRQIRPDERPFLISRSTYPGAGKFTGHWLGDNYALWTILPGEEAYKAGAGMAQSIDGVLQFQIFGIHLIGADICGFNRNSDEELCNRWMMLGAFLPFMRNHNTIGAIAQEPFRWDSVANASRIAIGKRYEILPSLYSHMGKASASGEPAVRALWYEFPEVFEQTKDYAHQFLFGDDLLVSPTLEPNVTEIKALFPNAGGKWRNIFTFEALDVEYNKNVTVSAPLSTINVHLRPGSALLTHSNPAYTVYETAQSPYGLIVNLDDNASANQTFYLDDGTSPAPTPNSTLSISATEGMVKGSIDGEFKVSQPLSYVVVLDVKTKPNQVQVGGSDAQFTYNDAIGALNITMASADLNGEWSINWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT53</accession>
    <name>W3VT53_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT53"/>
    <dbReference type="HOGENOM" id="CLU_039675_3_0_1"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000002">
        <property type="entry name" value="Pre-mRNA processing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="121"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="411" mass="45021" checksum="D3BC84D3D5CBF414" modified="2014-03-19" version="1">MDLLKAEIAAKRKAAAEASSASTSVAPAPAQNKYIRRGDLDKLREEHQRSASPSSSPSSPSSSRPAAPRSSPPANKRLKATHTDHVSRSASPSASNTLSAATQAALDTAAGEVEREKFNVSNDEAVRRLRSKGEPIRLFGESDKERRLRLRALELIEEKGGGVLGQNDFRNALQSAESATALELLEKRNAANKGKTEQARLDSLRPDAATDATDGDGASPLRASPDAESSKPTVREGVGMNSVLDLGLIKTDIDRVYPIIYYTLKGLLQEWADSLAARPDEVKHTMQGKLAAATQVQSADYLKPLFKKLRRRALTPDVLMRIAEIVHYVQKREYRHANDSYLQLSIGNAPWPIGVTMVGIHERSGREKIFSSNVAHVLNDEVSRKYIQSLKRLMTFAQSKYPPEDISMMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT55</accession>
    <name>W3VT55_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT55"/>
    <dbReference type="HOGENOM" id="CLU_031468_10_2_1"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="193"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="390"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="61228" checksum="789E999584D3D5A0" modified="2014-03-19" version="1">MRYHVLGVGSIGSLIAFHLKRSIKLQRKLLQPGPSSKSRRELLLSNLSNKRPASNQGSIVSSLSLPPYVQSELPDPLQSSVTLHMRRRPFGRAAKQRFANSIILEQDGVRDIEGGFQTDFTASAADITASIVRDNRLQEDEDDTGAGRFTISRGTNSSSSEDAALREQTTSRTPVPDHDGGVSLISTLEGVHSQPRAGPIDSLIITTKCDSTLSALEAIRHRLHPWSTIVLLQNGMGVLEMLFDRFFKDADQRPNFVLASTTHGCWKKGPLDVVHASMGTLHFGIVPSARAGSIGFESSRVPLGQTLTMPQGPMSRRRRAAKNARGWDRFSPDADAQDAVTELNPQDAEAPSKMLSLSGIPDQPSLRTLRTTVAALLSLPLQVEWETIRDFQLRSLRKLVINACINPLTALADCKNGDLFGNPAAMDAMWTVCLEAGMVLEAQVREHLASSQASPRQTASAALSAEDLILRSTETGEPMLHPSLTPQALYQEVQRVARLTAANWSSMHSDLKNKRGSTEIDYINGYISALGRGYNIDTTANDLLTNLIKLKTTRATGTNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT56</accession>
    <name>W3VT56_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial Rho GTPase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">GTPase EF-hand protein of mitochondria 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_00757</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT56"/>
    <dbReference type="HOGENOM" id="CLU_014255_3_0_1"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000474">
        <property type="entry name" value="Mitochondrial Rho GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001330">
        <property type="entry name" value="Mitochondrial Rho GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="20">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="20">
        <location>
            <begin position="481"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="426"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS64793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="752" mass="81906" checksum="1E3EACB2FDC14E26" modified="2014-03-19" version="1">MRKDVRIVLAGDPDVGKSTLITSLVKEAYVAKVQKVVPPITLPPEVAPEAVVTKIVDTSSSQEHRANLEAELRRANVICIVYSISAPSSFDRIPTYWLPYIRSLGINVPVILVGNKIDLRSGDVTNAALEDELAPVMAEFKEVETCVECSARIPLNVSEVFYFAQKAVLYPTAPLYDSREHVLKPGCVDALKRIFRLCDSDKDGLLSDAELNEFQRKCFDTPLQAQELEGIKDLVIHAPIAGMRYSHENASVAASGSSINGDAPAHHPHLREGSLTMAGFLYLHTLFIQRGRLETTWTVLRTFGYGADLTLEDSFVKPAFAVPPECSVELSPLGYQFLTDIFEVHDKDRDGALSEEELDSLFITAPDSRHPWQGTGFPASTITDEHGAVTLQGWLAQWSMTTLLDHRTTLAYLAYLGYPSFPLSGSSASTSAPSPTPLTPTGPPGSRPSRNHAPSPPSTTSALKLTRPRKTDKKKKGAIQRSVFLGFVLGAAGSGKTAMLRNMVGKRFESAYEPTQKMMSVVSTVEQAGAERYLVLQEFGSRYEAEVLRNTAKLSAADVIVFVYDSSDTNSFSYISNLRQQYPLLQSMPSLFVATKADLDLAQQRHEVQPDSYCRKLGLKIPGLGAGPLNISIRDGQVADLYGLICAIAVDPKGAVQGGNDRNALSFSTNRWQFWGYIGLVVVGGGGAVWICARVLKVPIGSTLGFGSTTSQAAWWPSRSDARGAGASDATRISGWLDWIRWQGSSSVRTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTA5</accession>
    <name>W3VTA5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTA5"/>
    <dbReference type="HOGENOM" id="CLU_2004875_0_0_1"/>
    <dbReference type="OrthoDB" id="10505920at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833379" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13422" checksum="C66743065909FA96" modified="2014-03-19" version="1">MLRVVALLAVLLVAVAARQLPDVVCSLPACTSLDRLRDDARGVSFHPCPGQVVAQTRLAAVDIAPDSPIAQQIWDTDPTPDAYWIAQLPMPPQLPSLPVMPPPRMIKFARSVDPTLDDDLLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTA8</accession>
    <name>W3VTA8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_00822</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTA8"/>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_1"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="182"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS64853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="492" mass="53888" checksum="5A6CC9B205DB97E4" modified="2014-03-19" version="1">MSSQAVADIGLIGLAVMGQNLILNMNDKGFTVCAYNRTTSKVDDFLANEAKGTNVVGAKSIEEFVAKLKRPRKMILLVKAGPAVDAFIEQLVPHLEQGDIIIDGGNSHYPDSIRRAKELEAKGLLFVGSGVSGGEEGARHGPSLMPGGSDAAWPHIKEIFQKTAAQSDGEPCCDWVGQTGAGHYVKMVHNGIEYGDMQLICEAYDILKHGLGLKESEIGDIFTKWNTGVLDSFLIEITRDILKYNDEDGVPLLTKILDSAGQKGTGKWTAINALDLGQPVTLIGEAVFARCLSSLKGERTRASKILGGPQIKPFEGNKEQFIADLEQALYASKIVSYAQGFMLMREAAKEYDWKLNNPSIALMWRGGCIIRSVFLKDITAAFRKNPELENLLFDDFFNKAIHDAQEGWRRVVAQAILWGLPTPAFSTALAFFDGYRREQLPANLLQAQRDYFGAHTFRVLPQYASAKLPEGQDIHINWTGRGGNVSASTYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTR7</accession>
    <name>W3VTR7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTR7"/>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="240"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="556" mass="61267" checksum="912157B7DF05F961" modified="2014-03-19" version="1">MGRGSAARIYVGWTTQAAWAVSGCAIAALSLPHGDMGPLGTLRGLSLCQVVDVERWRAHPTPGRRSFPTFACSHGAASSPRHLDMPCSLTPPFAAPPTSLTLNQSQAPHLLALERLEPDDGTATELQESLSVPVFAYIPSITTMAPVAVEPRPTSPSVASGSKANGKRFAGASTNRAHNYSSEHFDLGALATEDDYPYNDFKPSFPKVHWDAYEPIEPPTDRGLFADPEKKALFGAATAVKDLTRTIGTELEGIKLGELSDKQKDELALLVAERGVVFLRGQDDWTIDQQLELGRYWGPLHKHATTGVPARGDLDEVHVVYAHPTSDPNEKVYRGPVQHSRADLWHSDVTYEVNPPSYTSFKLLVSPEAGGDTLWASGYAAYDRLSYPLRQYLESLTAIHSAVDQAEGARRYGNTVRREPVETEHPLVRVHPVTKHKALFFNPGFVKYIPGVPKAESDYLVQFLTNHVSSASDFSVRFKWNAGDVAIWDNRTNIHSAIYEDVGVSRRHAVRVAVRGEIPTDSEDGTSREEEYYKARGFRVDRSVQKGQRRQAGYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTS5</accession>
    <name>W3VTS5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00858</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257606_0_0_1"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PIN" evidence="9">
        <location>
            <begin position="106"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="10">
        <location>
            <begin position="1305"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="778"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="855"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="902"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1370" mass="148323" checksum="9DF9749F3367DC41" modified="2014-03-19" version="1">MPTYADLYNERLRALGQSGPSNLVRLTISKGDYVWDPQQDRFRYEEKWEEEQLMEAEELHDDDHLTASLHSVASDSRDSSPGPIAALQPTAVLTTFAAVAHSPSLWVLDTNTLMSCLELLKALFAALLTRNVASAAAAGSQQTHLAPSPIKLVIPFVVVSELDGLKLTRRKDDSGRQVASQARDANHWLLTAVQKQKRVPIDASGSNLPEQLWPLFLQTSSHYNRSKQSRSQGSRWTFDDPLSCDDQIVKYCAELKHQTHSSVFFCSDDINARTKAESESIDSLGMRELAHALRTGFAGVQSSERKWELVAEALIEQWEYQIGSAPAQPLPQHSQPAFAQEGQFNSSSAPSLQPGNIAHFADVESFEVDMDTEEPLLHSTEAHVYPGGAAMSTPPTASAPPRFSSLAHSPGRSTSDSIHSPHNKTRPERTMAARARQQDAAVPATSTREPAQADNSEALNPQISWEDLVQQLGSGSREAAKPRNTRRLSRSGGLCKMARQPAKRRRVAPTQDLDVEGDEDWQSDEISSLPASDDDDLSSASGSGSDSDSGSASGSDDERNEDDDDEDDVIDMLKDPKPRSAKGKAKANDTVKPDVEVVIPIVNGDAPNEPLKRKRGRPRKEPKEPEVKVPKKRGRPRKYAPGEKRPRRSRRKLNPDGSFKKRGRPKKVVDPDAVMMKVPKRRGRPPKQLAEGEEVKPRRKGAASGTSTRKVKREFDLLAGLDLDLEDDSAGIIPGVGRNDDDAWEDETESPRTQDDLLAKLRRRILYRQKDAELQDFIDSLGPDGEPIAASARTKEAAPPTADEAQDSVLLNEGERPGLPLLKTIVAPSVPSSEKRKERQPFEPGAPADTPTDGAMSALADAAASVAAETEEQQPRQPKPKGRPPGSKNRRPDFENNPLINAARSSTTRSAMATPDHGSSLSLYPSASTSTAAAGGSTSSLVKPTSSDAYFLFNTSKRARGLAGMGIGTSGTLISSKLRALDARRLEGVVEAQTREGSLADIASRMYRHLLPVYFAQLLAGYAIIFHGVGSKTQLLTELVKRRIEAEGDAMGVVAQGAIKGFKVEDLLAEIESALSLGPLTLATQAAEGDEGVVVVSTLTAARAERIVRRFNGTAAGGPSRLFLILETFDAPGMQSIRFKSVLEILARSSHIHIMATTEHINSGFVASSAQQAAAGDRTDEDRTARLRWIWQNMSTFILSLDEMLMMRSNPAFATWMPVLPPALDLIGSSASFAAGTSATGTGAQEGTGTAYFNGLQVSEAFRTVSETSAISILKSVTTKARALFNLLAKQCLSSAAEGSEVQGVGGVAYAELLNKAKRSFLASNEADFKSLLIEFKDHHLCHINKQGTISIGLADAGVLQQVLDKLKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTV3</accession>
    <name>W3VTV3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTV3"/>
    <dbReference type="HOGENOM" id="CLU_612694_0_0_1"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13180">
        <property type="entry name" value="RanBD_RanBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="318"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="447" mass="47514" checksum="26A025C1838C44A2" modified="2014-03-19" version="1">MSAKDAQTEQPPKADAEQPREPQSQPSSPPSQRSSSPQLKPTESTSREVTAKSPPHHSEDASSSRKREREGSVEPSQMTPSRVTESIPAKKNRLEDSLQEEDDDPTAEQPETEKVGHIREKVHQLSTHEIKAAKPETDNKPEDDNVAAAPSPSASKDNTTAAPAKDTDAPTRTQPTFSAFSSKSSPFSAVPSSSGSSGAKSGFSAFAARSSSPLVGSGIKPSSLGSSIGGHHSESTSASSSAAPSSSTSAPAKPIVKGSTFGFGAFAGASPLAKPKSPAPTASPKEADKAEPSDDKATFEQKLLSEDKNAVAETKAKPLLEVSEETKTGEEDEETIHSIRAKLYTMADDQSWKERGTGTLRVNVPKHSARDKARLVMRADGVLRVILNVSLFKRMKCELHEKFVRIVAFEDAKPVHYAIKMSNPNNAAALMDVLDEFVLAPDAAQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUH4</accession>
    <name>W3VUH4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="6">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRT1</name>
        <name evidence="10" type="ORF">PaG_00902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUH4"/>
    <dbReference type="HOGENOM" id="CLU_011152_4_0_1"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000947">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="41"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="745" mass="85780" checksum="45C912C14E3C1DE0" modified="2014-03-19" version="1">MPSVQDITNGVDELDIIDDADIDFSDIEQKYSVKFDEGLDDVIVIEGVPVITESRQQKLFETIQKRFKTQAGIDIAVDGMHIPYADNGESKGYLFVEMASAEDAAQAIRQMDGYAFDKKHRFSVHRFTDVEKFASLSETYVEPAEEEFKPREHLRSWLADPAGRDQLVICRGDDVEIAWHNRSSDPQVEHSRPRWTESYVQWSPLGTFLTTFHRQGIQIWGGPSCERFMRFPHPGARLVDFSPSEKFMVTWSHEPIQVPDNAPIGPQFFGSEDEGNRIAVWEVRTGHLLRTFPVPQDENGQPGQLKGFSWPFLKWSPDDKYCARLNPGQAISVYETPSMGLLDKKSIKVEGVVDFEWCPMGDRDREAAEAGKPNKKARDNMIVFWQPEVANQPARVTVMAVPSRTILRSKNLFNVSDCKLHWHPQGDYLCVKVDRHTKTKKSMFCNLEIFRVREKEFPVEVVELKDPVTAFAWEPFGTHFALISSNDPQLGTPAPGITIKTQLNFYHLHPKGDFRPLKVLDNKTLNTLFWSPRGRHIVAATLGSSQKFDLEWYDVDFMHEVRQGNPSADPADDVKLIGTGEHYGITDLEWDPSGRYVATSASVWRHSLENGFAIWDFKGQELQKHIQDRFKQILWRPRPRTLLSKEDQKKVRKNLREYSKQFDEEDAAEESNLASAERELYQRILEEWKAWRARSRRDLEQLREDLGREAVGQSVDHAKKLAEEATEEVQEWMEEIIEETEEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUI2</accession>
    <name>W3VUI2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUI2"/>
    <dbReference type="HOGENOM" id="CLU_667514_0_0_1"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="301"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS65204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="412" mass="46120" checksum="B92B9FA8E3CC6903" modified="2014-03-19" version="1">MLRLAAIPLSLRSATRLASAPRLSCRLKSTLTVVPASSSAPREVPTPLLFLTASKWTSSPPAPEAYSEWIQHFSAQGYESLLLDLDPDQPVSELKDSAKLMEVFEKDAIDTLRQSGKTPPFPPIMITGGPASLIAQTYVSSRPLTALQLIDPPINNAYLRKDRPKLLPTELAEFDFEATFPVRVVWSDTELQRQQQQGVPWYDVHRIEHEREEDADESLDRYTFADTKQGALDTQEWLEGEVGVLGDQATSPLEDVASSFETESDSDSAGEAAGMRNADALPEWFVAGEYTLQPGSRKYPLTLDERDLAEKFVRGSGPGGQAINKLSTNVQLTHLPTGTRLTCQETRSRDRNRELARRRMSLVLEKLVRGESGGSRIDRTIEKERRKKSNKKKKQKRRQRDKQLESQTTTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUS1</accession>
    <name>W3VUS1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Myo-inositol 1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_00289</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUS1"/>
    <dbReference type="HOGENOM" id="CLU_021486_2_0_1"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000334">
        <property type="entry name" value="Inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000907">
        <property type="entry name" value="Probable myo-inositol 1-phosphate synthase (MIPS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000055">
        <property type="entry name" value="Putative myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="18">
        <location>
            <begin position="348"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00070063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS65220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="565" mass="62195" checksum="B8EFFA58723A9036" modified="2014-03-19" version="1">MAPVANGNNAANGQAANGNGNAANVPVNPTNARHEQREFIRVNSDKVQYTNEAITTDYKYLNTHVEKVHHDDGTTEYVATPIERQYQFKTERKVPRTGLMMVGWGGNNGTTITATILANKHNITWHNKDGVQVPNYYGSLVRASTIRLGTDPATGKDVWVPFSNVLPMVHPNDLVLGGWDISGLPMDQAMARSKVLDYDLQRQVAPYMAEMKPLASVYYPDFIAQNQEERADNTLPGQSKAAHVDQIRADIREFKRQNNLDKVIVVWTANTERYSEILAGVNDTADNLLKAVEQNHDEVSPSTIFAIACILENAPYVNGAPQNTFVPGCIELAEKHKAFIGGDDLKTGQTKVKSVLAEFLVNAGIKPLSIASYNHLGNNDGYNLSSQRQFKSKEISKASVVDDCCAANHLLYRPAVPGKKTADGKADKGEHPDHCIVIKYQPAVGDQKVAMDDYTSELCMGGRNRLYVTNLCEDSLLASPLLLDLTILAELMTRITYKAGADDKEWNSMYSVLSLLSYSLKAPVVKPGTDVVNSLNRQRAACTNFLRACLGLAPESDLLLETRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUT2</accession>
    <name>W3VUT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUT2"/>
    <dbReference type="HOGENOM" id="CLU_010507_0_0_1"/>
    <dbReference type="OrthoDB" id="3363718at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="252"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="685"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="947"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1061" mass="116249" checksum="862F4FCFB5AAD35D" modified="2014-03-19" version="1">MSKSIALPALTASIPAFYHFLAPKQAVAQGLFLPVGYGYVVSTVVSALWVTFLMGVKVGSARKAAQVPYPYLYAEKAVAEKNRDAHLFNCAQRVHQNTLENLTSFIFLTLFNGFFFPRLTAAFAATWVVSRIPYAIGYYSGTPSKRAFGGIFGGLSFLALLIQATYRYAALQPGSMLSSDAYAAKGYGEPCLLRVQAGIESNGRGESREADGRSGATVTTEEAPSDFPPVSPRVVLPGRKEEAQLLVYFFRPRGSLAPSPTVRRIRSWATAVSLYLEAFLCHLHTLLYFFFLHTYEPASRAWWDSSKGSAVVIYAPHNDAVARYVALRLSSGSPSSFALKDVGPTKRNPRAPYTCFVLHADSDQFSITVAQWAAKKARIEKALLKQKAGRSSESSSSPSSPTSTTHTFDAESSADRSEPSSPSPTPSAQLGPRGDETPRASRKSRPPPIQINRRRRRSRSWSAWATPDLFGYGIDMLKGWMPGRSGPKATPAGTIIPIMADVQTADGLAMINSTISAYCNSHDLLLSGVILVPSVLCPRNVPLTKAARADMPKTPGSAYSDVDPFSLCNRDVWGEVRASASGSTGRLGAGLTGPRDPFGLAPAWREASDLGASMDSSSFNAASPPLSPTSARIVRTQDDHQAALHSALATDVVQAKALINVLFPALKRDKGRILGLVPSGYGPELPHDPDTLSLQSLPSRNGSGKARDRSHSGSSSSADLMPERDTMPVLKTWPGAVVNTVREALRTQYREMELEYKRRGGSAKHVHVSTIETNALVRLPQTRLKKMVKWNESVRFFNTRKRMAWRWRDLLQPARLLDRLPFIARFGRLRGEDSHASPPDGARYGIYIPAELRPFLRGWVRPLSEARDEDDIYSTAPALVRLVRRLVRVLRWIEQCCIPWDDLAEHVAAVSYPIALGSSCPPTPGPSQSLLHPYTVSSNHAPSAHRQLWSGTSKKVDDDEDAADFPFSTASSGPAVTLLNVKAEPVRVPRTYPRELSHQNPTPLFESIRSALTSYHPRRTYYPTLAGWMAAVIHDAAPWVHEWIKPALAAYLLQYTVESQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUT4</accession>
    <name>W3VUT4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUT4"/>
    <dbReference type="HOGENOM" id="CLU_373915_0_0_1"/>
    <dbReference type="OrthoDB" id="2552411at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="637" mass="70045" checksum="DE4B47674B9DBB09" modified="2014-03-19" version="1">MPNHTPSPGGGEDHLRPPPASASSFSLRSEADTAGYITASSSRVSHLDADPVTALPRITIESLSSTPGRRIAHSPSIDSLSTGDTSDAPHMASLSSVTTFVPTSLTSDGSDDEEPKEPKVEEEFVPSYDFGLRDSHERTDDEADGSAEYDATMLGEAQEGDVLTISHSHSTSLATHPHSRFASDSPARSFLPTSLSASWPTLPPSAMKLQRRRRNLLLRLLKTWEGREQVLQLSHSLVLLLHASLDHPVPRSYRAAMLRPAGAVLALSFPKPVRVALMQRIYTTAEGIDNFRRIVLIARWITAATEATMEHWQHRKHARKQSQAELDEKLTGEEPRDKPSDHTNPPTWPTTQPSFDVFDEQHGPPPPAIGDGGWTLVQRVRRVWSRVWTLSHVEAAADTVGTIGEACETAAVLCGGGMFWRAVGIQSLGLPFLSRRRRRGVEHIGIVLSLCSVMLSLLALRMERASLRADVRSAHRRITRANDKLGWASDLAGTTIDRNQALSLRKRNPTRSHRPAPQEKELQMLGDLQDASDIDDVSSTSSTSDDQPRRRGGPHSSVDSLRRSTERALVRAESDLKTARRNVRINSWLKLANWSEVIFLAYEAAAPHIDKDAVEAWTGVAASTIRLAALWISLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUU1</accession>
    <name>W3VUU1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_01038</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUU1"/>
    <dbReference type="HOGENOM" id="CLU_008958_4_0_1"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="14">
        <location>
            <begin position="290"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="719"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="518"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="609"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="611"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="788" mass="87002" checksum="53D485ADAEE2149E" modified="2014-03-19" version="1">MAASSSSSYLAAKSLAWASGSLAAAGRARPSMRPANQLDVLQIFVPGLRSPASGFSTAITKHYHQRRKIEDTQALVRRRFARNHSTDSQQRSTPSSSSSSPSQHNHSYPPPGPLSKDTKTTSEYQGQSAGAPPKPPATTISPLPASTNTAAELGSPANQTAASQSLIAEQKAKEARELEASKPKGPLTTRIWAKVKEEALHYWHGSKLLAKEVKISSRLLRRLMLGYSLTRREKRQLKRTFADLLRLIPFIPFIIVPAGELLLPVAIKIFPNMLPSTFESKFSVEEKRRGLIKVRLEMAKFLQETIKEGGLQATDKVKTSEEFKEFFRKVRSTGESPSNQDIIKVAQLFEDDLTLDNLTRPQLVSVCRYMQINAFGTDNYLRYQIRHKLNRIRQDDIVISHEGADNMSQSELVSACQSRGIQTTNLSEDRLRQELQQWIDLHVRNKISGTLLVLSKAFNYVAAGNNDVNAQSHLRSLELTLSSLPDNLVNEAELSVNSERATNKQRLEVLQQQEELIEDEAEQEQEEAAAREAEKERRAAEKARLAREEEEARSLLPKKETETETDPALEDARMTNEQLTELGEALSILSAKSSVLKEREELAQLIKEVSSSDACAPDASAATASSDAAGAAQDGSSASTSASATETSGEAAAAPSSSSSSSSRSMAKRIKSMLEKIDNQLEEYDRDVGSRMHLIEASHTGKISVDDLEQALRLIKHKPDDEVIEKIVDKLDVDHDGLVPLDDVLELARAETGLGILRDEGVKQIHAQGQQIRNKDARKPKKSDIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV12</accession>
    <name>W3VV12_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV12"/>
    <dbReference type="HOGENOM" id="CLU_045202_0_0_1"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="366" mass="39256" checksum="4BF56A703F8547BB" modified="2014-03-19" version="1">MSLSLSVGAPGSKPSGSSGGPSQLVASLRERGVTLPNFGALKSKEVRGGHRQSVRGLGWSVDGRKLVTCGADRIVRIWVPERSVDARASTELKGHSDSVDQLVWHPSHADVVATASADKTVRIWDTRARAQTNTDGVTTVQTPGANINIAYHPSGDYLAVGDKTDTVSVVDTRQNRIVHTVCTRRATAPTDACSATTVVGTTDEINELCFSPDGSLLLLSSGSGSVHLHTTVDYARVHSHATHTANVFCLQWDPLSRYIATASSDSMVALWDTKEWFAHKMITDLTFPARAIGFSHDGELLAAAGEDRFIAINATQPNTEPDSLHKIPLPASTTINTLAWHPAKYILAYAGDEPQKDTGTVRIFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV36</accession>
    <name>W3VV36_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV36"/>
    <dbReference type="HOGENOM" id="CLU_089717_0_0_1"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF1">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS64651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="234" mass="24263" checksum="0264A25D869FA840" modified="2014-03-19" version="1">MASASASASTSGSGSTSTPASGSGSAPGTASSHDSKLATGLSHKAAGNASFVSGDISAALSSYHHAVLYLSGLQTRSILGLVGESTTDSKPEDLDSDSDDGTASAPTSEVELSQVYSNMAACYLKQGRWDRALDAADKGLRADSRNVKAKFRRAQALRGQNNLYAARDYLQLTLDSLGNKRADAKVGFQAELNKVQAEIGIKEAKARNKWVGFLGKNPGALSVDDRTDAQAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVH6</accession>
    <name>W3VVH6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVH6"/>
    <dbReference type="HOGENOM" id="CLU_1917963_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="132" mass="14040" checksum="7ACE0B0693B788B8" modified="2014-03-19" version="1">MTVSAVLAADAPRSSTASLHPGPFGVAAARVQARCTSADLARMPRAEECAAAATRKPTTLRILLRSINHDAKHALDVRPKVYLRPQPSNPQPAASSSTTKPPLGPTTRSYYSTPSDARRLVQMNAPSARLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVW8</accession>
    <name>W3VVW8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVW8"/>
    <dbReference type="HOGENOM" id="CLU_319130_0_0_1"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="911" mass="101164" checksum="203D1DBDE8B57668" modified="2014-03-19" version="1">MSATADDVKARLSQLRADKALLQAQLESLRRIPDAPPEPRDTLDAENDELGHQLRALEEKAILYRSAAWTCFEIDLDVGRRARLARRNESATAAADKDADLALGIRLDTFWRGRFYEPYYLVLARPSQMLESLPQLQGTTGADAEPSSLDGLRLIRHTVPHFVPLLKLVEKYLPSVLGGELSGGAPSAARDNEAGGLTMLAQFSDLPGVHAFLSDLHCHLQAYVSRRQQAMALRQLKLPTPNANASALEALGTEAFDMVKITWHVPSASAEAAEDDEDEVAANPTAVAVQAVAKRKREMPQDEPMHQLEVVVRYADLQSDRLVDDTRPTGLFSMTGSVDEEQDDFEGLRRPYGQVRVHMLEYAPELDTRQRRTPGISRADLGALRPETVRRQDLELLYAQAHDGEALDMDDAFQRVAQRVWSQRAKSSVEWQRNVWTWGSRRRRRLLKPEIDPALYRKEAPNFRELARKHPTFAEIVIDDGGYEAKVDFQDAHALRCLAETLLLHDFGVQATLSPSNLCPTIPNRLAYIALIHEMLCWTLPTWHLVRHMQGSTSSSDAVVGLDIGTGASAIYPVLGTRCFPHWRFVATDTDEASLQYASTHIVDRASNALSDRIALLHSDGGAFVPSAEGCKQVGGKYEAQEVHFTMCNPPFYSSAHDMQRSASFKSQPPSAMVVEGGEAEFVRRMLRESAAQAGVVWWTCMLGKLSSVVELAAELKAMAKSGDVGGWGMHELPTGRGRTKRWVVMWSRTPMRLPDSLARESLPSAVRDVPVATERRSKAFALGPTWTRREVQHVALDILGALKGCHVYASDCDDSARLAGTFEVVVTSECWSRRARRAKLQTHPAARTQEAEGQSGIMLAARITVGEAQDAGIQVRVHWTYGLDAAKFESFAMFLIAAIERKVEEMRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVZ1</accession>
    <name>W3VVZ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVZ1"/>
    <dbReference type="HOGENOM" id="CLU_249300_0_0_1"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="975"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1233" mass="129555" checksum="6EF68071AFA3A012" modified="2014-03-19" version="1">MQSAPSSSRTSHIEPTSPTHRFPSRHSHRDQHLTLHSEPDYPTSADSPIDTHPRRSLARSLHRHAPPSADAQPQRDLSPKTTSQQLGPAPGLPLHPTFAPSSSSSTQQPPQSAASPSAVSSAAAANPSTLQLLTILHSLQQRSSKSAPEPAQQAQLENLLQQVAQVFGTASPASPSEAPLSSPALRPLEPIPVPNARSPAPHPAEGASTATAPAPATLQSGKENRRVSLPAQAITKDSPQLGFSEHISRRPSASSPALDHDDAAPSPSIQRKEHESANRICYNCGTNVPTTWRILKLPAGSIINNPAAEKPAATTNDASAADDSESGWKPRYDATQSPVHADGESRWSACNPCGLYYLKWNNSRPEYVWRKEHATKAYRERKALADAAKRRRDTVEAGSSKRARIANSDVDAASPYSAAATPHGHNKPNADAEARDESTSPNYDASTAASSSGRKASMPRTLSEACHRDAEKLESQRSTKKKEKEKPLCKKQADREYVLDHNTGKWRSRRSMRENPEGKRPGRPKGSVKVPQNAAKPGAADSSPPTSTKDDSQMQPVGASAKQADAGSSSSSDASGSKPSGSANKAQSSLAAGQREGDFRLPAPPQPMAPQLARQASASRMVNFAQSSPVRPSMNASLMQPEAVNALHRFGAHMLESPSRDVRFRVPSYLMNSSPGTMLDTLMSEADFDFEELGPLGPLQTPGTLLGNMRDANGTPLRLRRSPRKNPHGTISGQNPYASPTAKRGSPSFGRERRGQVPESPSRRSLVASSSASPVTRSRTRSGHGVLHPALYSSSDGAENAHAKSSSNVTSPASPSEAAGKAKGKGKATSSLQATGKTQLASKQAQVEASARAASRRRRADADDQDDDAPETQFVKGPYRSASREGSAGLPSCPASPSLGRANRKLGRHLSSVSAHSPQSGAATLARLDLPPSSPAFDLPTACSSGSIEVDGWGRTPSMREIFPTPSDLDWPSDASPATQDAPTTAPAVQQAETSESKELVVKPCTAVVRRRPLPATVEDGSSSVSGSSPAHSDDSPEGSTNMFDLLEDPYGILAASGFGIDADGALTSLEMPVPAQQQMTPTSSAAASASAPSISADKFNDVSLHPAQEFGTHLSEFNSSGGVGVAAHVAGTGTAAAVQIANASDANANPLAGVDAGFLATLPRELSAILTSPKKNIPPKIIELLASPSKAKPFADPPSPGLERVQGETHDFSALFANPDIQALLAEFESMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW48</accession>
    <name>W3VW48_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW48"/>
    <dbReference type="HOGENOM" id="CLU_837210_0_0_1"/>
    <dbReference type="OrthoDB" id="2359117at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039198">
        <property type="entry name" value="Srl3/Whi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246:SF1">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="286"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="381" mass="38172" checksum="92849082CEC0232B" modified="2014-03-19" version="1">MSLVHTVTTTAAPITSSTKSTAMPSHPSDPTSASSAAMPSQSQSLLLAPLQSSTSSNVAITPSKARKQAQAQRTRLVALSKHLMTRLQYANFKVEHGWSKQSLSEVENLYYRQNQSAGTTSNATARTQKSNSTSPANGASKAPATPSAATAHGQKGVGSRLFKDAAIKKIDVEGGDVFGGYGLATPPASAGSAPGATSYLSSKRGRSTSSTPISPPNTSAHSSASKGGDAASAPKRSPNGNSHTSGSGSRASHVVASGAAKVSNPPAAAGGATSYADFWSRVGSSAAASSTAVNAASSRSASPSKKRSADDVVAADGANGSDASAAHVSPAGKEGGSSSPSKRVRMDTDADRTSSWSATSSPAKAALAERGPSFASSVRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD46</accession>
    <name>W3VD46_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD46"/>
    <dbReference type="HOGENOM" id="CLU_041481_0_3_1"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="303" mass="32424" checksum="EC5705E355E80FC4" modified="2014-03-19" version="1">MATATSHNKKSSAVKRILSEARELANDSSDLYSASPLEDNMFEWHFTLRGPANTEFANGLYHGRILLPAEYPMRPPNLMLLTPNGRWELNKKICLTFTGFHEEMWQPAWGIRTALLGLQTFMTAKAEAAVGIGALDYPVQAREKLAKESRKWTCDVCAKTTLELLPDPDPEQETKQEALPDGLCVDLTAQSHKSQPSASASTSTSTSTPAAGPDAAARPIITTAATSEEPPAPVAAPTPPPPAPIAAAAPAAPTLPAPARLRPSFNAALPPHTSATQRKLSLIDNCIKALSVLVALLVVKRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD52</accession>
    <name>W3VD52_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="1">FBP aldolase</shortName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD52"/>
    <dbReference type="HOGENOM" id="CLU_040088_4_1_1"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="294" mass="32053" checksum="7D9CFE5BD4B57386" modified="2014-03-19" version="1">MPVDHTNNLTLRILQAAHEGGYAINAQSCYDAQSVIALVRAAEEARSPALCQLFPVTMAQFGKPFVKFCLDTCHAASVPIAVHLDHAASDEDITRALDWAEQGVALDSIMIDCSHHDTDEDNIAMAKPYVQRANSLGMAVEVELGRLAGGEAGVRVIEEGMLTKPEKASRFLTELGAQMLAPSIGNIHGRYVNPPAFRLELLEALQSAVGPGTAANSYLVLHGTDDLPDELFRDCVRRGAYKINVNSWARDPQVEFWAKHLEKDPLPDVYEGGMQQFAKVCNRFFHLLGSAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD78</accession>
    <name>W3VD78_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atos-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD78"/>
    <dbReference type="HOGENOM" id="CLU_375598_0_0_1"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="155"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="728" mass="77473" checksum="FEAA3D90DC167B47" modified="2014-03-19" version="1">MSFYSAFPTSPLSRSALEADSSSERTSASKSFGPKKSPAQPTSAVPIDPSRPDLPSMRKFASRVPLADTMPASLGLGHPVVSPNSSSRHVSGPARLMRSPNASVWSPSLAAPFDELAVSPPFASSSFSRSINTRRRSSGHSFSAASGHTPNFGSLVGSFQESLLSGRMSMPASKPLVFDAEVGVLGAGKCRPSLRCPPHLHIKFAAHFYDFHAIDARASTATPGSTAALGSPYVGTIDLESHYTSLLLSRRFSSPSTHAEPGEVPSFPGYAVPPKGQIQLIVKYPDLAAVKLFLVPYDLTDMQPGTKTFVRQKTVVRPAPLSAADSALDDARLGTSEGSQSQSRTSPKEALRFAIHLQFCCPPTKSRRQDSLAGFEGSDTRRFRSRADAAARQPRAPRIFLHKSIRLVFGARALDAGEKLVDCIETPGTGSLRFSAYQGPDEEWLQLQEEMRALHSTVAPVPEASTGTETAGMGLGIAIQTPSAGHARDEGDELSNFVPLNSDPNGERWQASVSSSTGAAAPQDVAGAMPASLRSTWSASSQESSLGRVAPSWPVPQHEQHGVGQLAHTLASSHLSDSWADQRPHWTGRSRPAADSDAAVSASSTAASRRPSRMRSASAAGLSEPRVHSVSALGELQEVAAPPSQSCVAPDPAHSMPMPAWKASGIASRSGDRPSLLRKLSEQFARSHSPSPANSPRLTPTRRHEHEHDELHIDEVTPTNDSHSRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDC1</accession>
    <name>W3VDC1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDC1"/>
    <dbReference type="HOGENOM" id="CLU_370497_0_0_1"/>
    <dbReference type="OrthoDB" id="2546564at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="751" mass="83693" checksum="9FA7809BC57B2BEE" modified="2014-03-19" version="1">MLFHRCLRPALAAIGCIVLSAAAFPITAGRGNYFAKTPEQPSQALELGGVLGKRGVAFLPFAHKRALSIEEPPQLTERSKERSHPDHIAYYVRHFKPNPKLKPLAFVRRGPYYADVSFYKGIPVFFPSTDPTALQREQRALRDFGRFFVSASSRKHPTNTEILLVDKTGLVTVAPKEAILQHFARKMSVVSEDNRVAKMIELGPGFAPRNRISSLRNLVLGYRTPKIKDAATWDHLPVKPGASEPWLDTGHAYIEALFGKALLLATENTSPPTFVSLFPLFNMLFTPWLRAALAIGCFTAHSIAVSPSSSSSDAGTIASGDDGPEALGHHSDHRESLQKRAGRNPWSDTIDYYEYLFTRNPRPQPTPPGLLDDYYADTLHYGRTPVFLAREGKVDMARQALVDHGSFWIVGDPVRSRDEPIPAFRRLANGQKVTEEKEAVLDRLYQARHFGEAHGDLAKKLAFGAPFAPARRHTPSGADLTWQEVRQDAITLNTNEFDIRQARALLAQHRMLKLHNPDTGSTIGFKLNEEGEVLVSVFSRAGRHLAKRGFNWTPSQIEYYTQTYKEDPSLKPLPRAARGPYYADVIFYQGYPVFFPTGDPTAIQRSKQALQDFGKFYVPASADGAPGDKIFLAVSKGGKVRAANAQGGIWALLMRADSRRYPMDPVEKALTLGPSFSKRKRPSGFWGWLRGYKTPKFQEVVQTADVVGAQNARIPDLWTKLENQGRLVVKNGESYTAYVLDKSGRVLTHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDC7</accession>
    <name>W3VDC7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_06575</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDC7"/>
    <dbReference type="HOGENOM" id="CLU_000315_10_2_1"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="298"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="633"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS59648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="871" mass="97006" checksum="615B55182C57BE6E" modified="2014-03-19" version="1">MRRSVILAALGGSPSPATGEADKGAGKVTAAKSSPLSRQPLADITRNANAAGFGPLLGRKPFKPPSFANQREKDSPEGGRKRKKVDYAGMDAGATDDGAAAQGSDSDDDGAAKGARAGAKKKGKAAMKTLEGVYKGIDANGVSLNVDRRKWDVFEVKPNAIKKGFSVPLMTNKQGQVVETVLSHAALGTRRQIDIPPRPLHDPMGEHAIVLFDPTVDDREAERRKAELQQEQAAEEERIEAGAPIPTPHKSLADILGLNKAKSKEVEKIPVVIDPILSKVLRPHQVEGVKFLYRCTTGLVVENAYGCIMADEMGLGKTLQCIALMWTLLKQSPIAKKSTIDKCIIVCPSSLVRNWANELTKWLGAKAPGTLALDGKLSKDEMIEATRRWCNASGRAITQPVMIVSYETLRNLQEELGNTEVGLLLCDEGHRLKNADSLTFQALTQIKALTQIKVRRRVILSGTPIQNDLSEYFALLNFANPELLGSRVEFRKNFEIAILKGRDAEATEKQQQEANEKLSQLSALVSRFIIRRTNDLLSKYLPVKYEHVVFCKMAPFQLDLYRLFIRSPEIKKLLRGTGSQPLKAIGILKKLCNHPDLLDLPSDLDGSEQYFPEGYTPRDRRYVNPELSGKMMVLQRFLETIRATTNDKIVLISNYTQTLDVFERMCRANRWGMFRLDGTMTINKRQKLVDRFNDPEGKEFIFLLSSKAGGCGLNLIGANRLVLFDPDWNPASDQQALARVWRDGQKKSCFVYRFIATGSIEEKILQRQSHKQSLSSCVVDEAQDAARHFSGEDLRALFAFKEQTVCDTHDTYKCKRCKSGKQFIKAPALLYGDTSTWNHYGKAEMHHLHDDLLRAEQAYDEVSFVFQYCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDL5</accession>
    <name>W3VDL5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDL5"/>
    <dbReference type="HOGENOM" id="CLU_918682_0_0_1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832971" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="338" mass="36926" checksum="2CB1C120C637C80E" modified="2014-03-19" version="1">MRVSTALLSLAALPWLARAAFHSNDTACTRHYTVEAGDTCDRIGQKTLTSTYQILAFNLLNAGADCYTLEIGSQLCLGRYGNDCQFVHRCSNSDTCESIANDYGISTHRLQDNNPSLDCNIVYEGLMLCVSAGSIRPPADHSINSTDVKVAREVARQAWIVQEQQKHNAKQAEHMSASAHSASKKNPSQSKQRGKQHHKQADAKQHDKQHHEQADAKHHHQHQQPKGDKPKQAPDARQHAAKPAPHDSKPGDQAHASAAQDGEHRGTQDGKSTPRAASMDALEEIAEDFTAAALAGSNHTPHSTEHHTPPPLDGATHSAHKRHRSLSSRSHQQSSHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDS4</accession>
    <name>W3VDS4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_06287</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDS4"/>
    <dbReference type="HOGENOM" id="CLU_049909_1_0_1"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="201"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS59763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="351" mass="37453" checksum="4993378FC63A6516" modified="2014-03-19" version="1">MSMLTHLPAPLAPPVLGLGLAVASAAWFTVSYVGSLYLSPAGRLNGGVDADGVPLDRDHPVVIRSRIRTASAATALSLVCAGALLKRAIPPSVSFGRLFHESITADTMLLDSQGWLLDTLNIGRLLGLALPVPTLLTSNTLPFAPPLLSYIGSLSVHMAAPLLLTSLLYLGPLLTRFLDGELPFQRHFDLHTDLVVKFTSLAGVRNFLVGPATEELVFRASLLAPLFFAGVSRAKLVLATPAFFGIAHVHHAYNVYLSDGRTRSAAIRGALTAAAQFLYTTAFGWYANLLFLRAGSVVAPTAAHVLCNVLGLPNPAADAQRHPTKSTRKCHLPQPVFVQPLLNLWRHCAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF95</accession>
    <name>W3VF95_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF95"/>
    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="72732" checksum="B1ABD0CC0B5D9CC3" modified="2014-03-19" version="1">MVASTKVLPEGAGWAVIGGLGFFFAGFMIVLSFIQQRYTNRSIKDTDEFASASRSVKPGLIAAGICSAWTWSSTLLQSSAVSYKFGITGGYWYAAGATIQILLCSIMACQIKLNAPFCSTFLEVLRVRWGKMLHCVLLFFSLATNLLVSSQLVVGGSAVASTLTGIPTMAAIWLIPLGVSVYVLVGGMRATLLADYTHTVGLLIIIFYFFFKVWVTSPEIGSVEEMVKLLKTSNGIQGNVGGSPLTFRSLEGLIFGLINIIGNLGTVFCDQSYHQRSIASNPATAAKAFLLGGSAWFAIPFLFSMTMGLSARGLLFSGNPLMPALSAADVNAGLAAPAAGVALAGKGGAVAMLIILFLAVTSASSAQQVAVASVLTFDVYKPYIRPNASQREIFIMSHVGVLIWAIVMALFGTIFYYAGISLGWLYLAQGIIIAPAVMPIFCGLVWKRTNKMACLAGMIVGVVCGIVAWMVTAATLYGEVTVDTTGKDYPTLAGNMVSLGVSSIITVAGSLLWPETEDHFVLTRSINAPVDVVERMAANSGRSSPGSPSTPSAEKSQYDSEKMAPPTATVPYTLETVDYVKAAGLDADELRRTLRQTSWISVAASLILCVIIPACLASRRIWNATGLAAYIWLGFIWLVWTTFAVGILPIWESRRELGAILRGVGKDLTGKNGKVSRDADSAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFB9</accession>
    <name>W3VFB9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFB9"/>
    <dbReference type="HOGENOM" id="CLU_165646_0_0_1"/>
    <dbReference type="OrthoDB" id="2555297at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834095" evidence="1">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="121" mass="12858" checksum="CCC78780C4FFA62F" modified="2014-03-19" version="1">MKFTQPIVVLASLAFATTALCAPISSEAGPARRSAEKPNLIDSVNAAVVDLGLRDVVEELNAAAEDLGLRRNVIDETNAAVEDLGLRRNVIDEINAAVVDLGLRRRNLIDEINAAVVDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFD8</accession>
    <name>W3VFD8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFD8"/>
    <dbReference type="HOGENOM" id="CLU_010348_2_1_1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="122"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="413"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="456"/>
            <end position="463"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="554"/>
            <end position="556"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="653" mass="73502" checksum="B7F98E691600BF53" modified="2014-03-19" version="1">MAAAKRKQQSPAAEPQHDDEDEKALDPKLAEYPDEDESDTSKPPTKRAKKASGSGAVVKGEKGVDNKYGSSAYAKSGDGWHRSDFNPAPKGRKDNRTPLQDLEDALKKHAPSKSNDVADAKNVVYWMRMHDLRIHDNRALAHASHLAAARRKKGKGGNLVALFVITPADYRAHDRSPRRIDFVLRTLAVLQRSFDKLNIPFVVYTHTGKRTEVGDKIFELCQQWNASQLTANIEYEVDELWRDIGMVERAADSGVSFSMMHDCYVVPPGRVLTNDGRPYSVFSPWNRKWTEAIFKDMSLIEASPDPASNDASIRKDAQLGALFDLQKLGDGFGIPEELEGFECKDRKYMAKLWPVDDGAPSQVLDNFMKGKGGETALDRPATEPSTKDVGGNAKDSRLGRYAEGRNLMNENGTSRISPYLAAGLVSPRECLRRTKELTKGKLHVGRDSGAAMWNTEISFRDFYGHVLAAWPKVCMGHAFITKYEDVKWETDASTLQAWKEGRTGYPIVDAAQRQCMQQGYIHNRGRMITAMFLTKHLLHDWREGERHFSLNFIDQDFASNNGGWQWSASTGTDPQPYFRIFNPLSQSEKSDPQGDYIRHFVPELRGVKGKAIHDPYARLSKAEFEKLGYPKPIVEHAQARQRALRRYKNPGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFG9</accession>
    <name>W3VFG9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFG9"/>
    <dbReference type="HOGENOM" id="CLU_014673_2_2_1"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="317"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="654" mass="71903" checksum="C1B98969E5E41EE9" modified="2014-03-19" version="1">MRLRTLVPHSLFSVLQARSFGTTSAFARASTAQAVWTRKMALRERYRDWPKEALLARIAELEEQSTAQRTAHLRPSTLETAPSGSSMDADGTVEGTKGKGKKEKKPKEFDFGAAGCRKIALRFSYDGAGYSGLAAQNTSVPGSGSTLPTVEAVLWDAMCTARLVDPALGMDGAGFSRCGRTDRGVSAAGQVVALWVRSKKLNHWTARLEHQAKFSSDPVPLSEDHEALEAKRNARLEDTELPYVQILNRILPPTIRIHAWSPVRADFSSRFDCVYRHYKYFFPAGPPSLFLAQSSCSSSAIAEAASTRLDIGRMRDAAARLVGEHDFRNLCKIDASKQITNYRRRIDGVSIDRVSSHWPTQPSNINDTPEGDEEMYVLNLRGTAFLYHQVRNIMAILFLVGARLEEPSVVEELMNTHEGAIAADRVKMQLAAQAARQGDGVQWWLPVNATATTTGASPTDAPMWVDRAPTHAEDGELEIYATKPNYEMASDRPLVLWECGFLPTDVEWRVGAYDGSLSQISVAEAAEDAWAASSALLRVHKTWTQQAVSTELARHFVLASAPPHGTLPSRTRFEHAAFPYLDSPVQGGSQGAGRGAVVPLGNGTGRGAANYVAMRERPREESYELKNQRWADTTGRRRAQRRAEAQAEPAAHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFY9</accession>
    <name>W3VFY9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 5'-monophosphoramidase HNT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidine triad nucleotide-binding protein HNT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HINT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFY9"/>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000013">
        <property type="entry name" value="Hit family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="12">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="10 11">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="141" mass="15550" checksum="B8CFAAFC94C8C58E" modified="2014-03-19" version="1">MAAKTDANCIFCKIIAGQIPSLKLYDSDKTYAFLDIGPISEGHALVIPKYHGAKLHDVPDEHLTELLPVAKKIAIATGADQYNILQNNGRMAHQMVDHVHFHVIPKPDEKQGLGVGWPATQPAKEELSKLHDTIKGRLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG88</accession>
    <name>W3VG88_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_06334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_268736_0_0_1"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="729"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="951"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1162"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1400" mass="150526" checksum="B0B47C07AB88DBEB" modified="2014-03-19" version="1">MPKASAPPPASSSSATASTPPPTNTTAGETGRIRSSRACLHCSRRKVKCDGLQPCNNCSKDNTLCEYGAQKKRGPPKGCEPKGGRKKKLSDVPPDVKPSTSSTPSVGPPAKRKAQPSTHTEAPAPPLPPSKLARTSPIHARSPLSRSPSRLPSFNSSLPPPNTHAYFNGSTDAAAASPSHSSSSSSKWDPLSHSRSLAEPVASRSQSYVRSPLPTHERSATHSQPPPSSSYNPSSSTADHLPWPRGAYSHPSTSSSPSLSRRNTYLNGTNAVDTAYPASSYPSTTHPSRTTTSAPTSQHYSQAYSSQHAHSHHQADCHHSDAWPASSSSPADARFSHDQPATSTYQYDSYPLQAPLRDYHRPSPLSSHRSMPPPPPHTMTSQPHSSYDTASHQDRSANSPFPARSNPTPSASTFASPRAQSTRTLYESPNPHYTSSGPSPLDRTSAMPPSTTALASRHPVSASRSTEPASSVSQHIASFASTSSHVSVPTTSPAFTGPSHGYSPSSTAMPHRPWYNGSQPSSPRGAASIPRSQISSPGAHWLDYHIRPGSAAANHPPSTSRTHLEDRLPPHILQRLLDIYQVFVHPHWPIIYLPSFTSLHSLKRSRPIVFEAILAVASNTFDPFLDTAAGDEQQSVNPLFDGLYAESPLGLDLAWKSNELRDHFVNRVKARIFEGKFVQDIGTIQAAILISVIELGCGNTSSAFQFGGIACRMALDMNLHRYSSQASASAAPSIHGDGGATDNADGERSEARRSGSQLQERLRVFWACFILDKILSTALDKPAQLRTAEIECDWPSVQEADEYDLWINETTRKFVDKGQLTRLEGVKVHALSSFKAWAEVMAILERILEEVYSPQAKRDRRRTKGASDYEALLRLNDRLSKWRADLPSHLKWSGTWTSPDVLFSAQSQSAYADRKESDPHRGLPPQILTMRAWYCTCLILLHRPRVPKLVEGPKEHATGTSEDADAAAQTDAKSPAAKKGKKGSQTSAKDKRSPAGLDICNAAAKEVCDILHVYGSSFRIRKISSSWVYLIFQSATIHAALAASKSVVAFKARQSSIWSRRGSKVAFGELGAPLADDHHELSARADDAEGHANGAEAFSSEAHHVPEAELEGASELVKTSALYLAECVRYLKRIGPTWQSASNHVSVLRNLCIASAQARPLSPSLKHGRGVAQPDPQASNQPAGTVKQEPAAFDSDQRGAPANDVGASMHGHTHQVDGAPAGDHGEHVPITGHEAGVNSQASYAAPISQHVYHEDRKAETMHMPSAATAAAGTTSELAMANTDGMQPHFLASQGYAPPAHPPAQLLPPAAVGVHSHLPPPHHAHHAHQQAGYPINANDAAFWASMPVASEGYNEWDEFFRAFNPGGAAADVTANPNYHPTAAVDLITALQDPNRLLNGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGK8</accession>
    <name>W3VGK8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGK8"/>
    <dbReference type="HOGENOM" id="CLU_398547_0_0_1"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="259"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="679" mass="73838" checksum="D505B048AD8657BB" modified="2014-03-19" version="1">MSASADPYLLASTILTPDELPKLALVTYDAAAHLDAVTSSSDLPPPHLQRIFVIVSNVTLGVEQSCVLVIKPRRKDPTTAALLSVIPILPDLKIEIEPQQGLTASAATPRNHPPAATTLGLSSLPQSLPTIHTLLESVVPDLFAPDKAATSNAALRFSLSFAGLSAEGITSDARGLKDFLSVLKDLLKVAQQHAFSAATTHQWMSAYTQDLAGPSHEHAPTAAPHLDTPVFSRLSHSSFVPSSAEAATAPARPASPTANDIRISVGTFNVNGQLPREDIPTIVGLKRWLRAEEDPDLIVLGFQELDTSSGAYLYYSPAREHAWTHAITQALGRRAPSYRKIAAKQLVGLLILVFARAEVEHEITDVAAASVGVGLGGFVANKGAVAVRMQVGSRTLCFVNSHLSAFEGLQAMERRCWDWNEIYKRLRFRIPLQKGEGVDGLTTSSSQEADREHEAAHDDAVAVTAQAVDASSEQTKPTPASDRDSRALSTPPTDDSATDPAWHSGVDVSTVSTSDVDGAAAEVLSTPFREHSILEHDVVFHFGDLNFRLDLSHSEAHRLIRARQYTLLHRYDQLESLRTSGALFDDFLEAPLTFAPTYKFDLNTDRYDTSDKQRVPAWTDRILWSVTCEWTDDGSLSATAEAGDKERRLGVVQQSYECVSELKFSDHRAVRATFVVRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGR5</accession>
    <name>W3VGR5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGR5"/>
    <dbReference type="HOGENOM" id="CLU_007534_0_0_1"/>
    <dbReference type="OrthoDB" id="3366922at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033349">
        <property type="entry name" value="ATRIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28594:SF1">
        <property type="entry name" value="ATR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1190" mass="130486" checksum="6117F14D1D40AA23" modified="2014-03-19" version="1">MAPPPLRSGGANGGIDEDEDEFDLLFDDQALLDPELEESLAQAEATYTASQAVQPAAPAAASSFRLSTDPAPRSSNRRGAFVPPAAKKPRLDPGPSRLGNAHRLAKPSLLAEPGPDQVIVRDLREDEDFGDKDDDQWWATNNALDQVEEEAIRMSQHMPTTQPNGTDRNPDARDARSNPDPSRRATTSKAAQTASKEPPDTSRGASGNHASANIDTDELDQLRAEIERLRAAQRAQDEMVDKLRQDAYRKAGEVAVVRQNLTKLNQENAKLREREVQREHEHRASLERLQKDQEKRLQRLETETAFRRVEQDTSRRIWPSSVARLPPVGLRDMDRRQESQVRAGLTTPTKANRYGVRGSGSSGNRQRFVDTPGNRQEPSTPTRSAVKPAPHFPRPTTAAGSASKSKPFRGLQNSFADFAPVQEKIRQHKSSPTKPGRAETLAPADWDADQTVPNDMHDDQDVAMADGDRSSPQARPTSRPRRSSDSQPAGTDASRHNEYRYLAAVSEILHQRTTIVSLLLSHESPPAAAPATYPASAFNTSASGPSTQAQETLRASGTLSRLISADLVRDCPQAVVFRYRRAVETLLTHMSRATVMEPEEREDALRLLWPGDEQADADEMDFAFATMHLSHAVASALMAMAGILLRLCQTDLLTDVLRLVSCLIAILPRFWMDLECLQPDRQADQDEIVFLRGPPADSDQEARKLSTPIQLREILAQSINDCRPQVVADTGDASSRLADGATRKGSGDWTLSSEAREDLLQAVVGVLEAMSQCTDTSNLAIVHPLRVLQRHGALHKLLHPERPSWLILRVVRMLSLAVSDAPLIHECLASKAESDSSGRGNGPVSTRSARFPVLEVLVKHLVDRRFDLPECEWHRLHSGILTLLTQAALHSADTAVVLADSAPLLAALIRCLSLDADLVWLHSRPTFMLPLRLAKFRPASSGKARLVADASGADLVQATERIVMDTRLLNLLYNYPLPIANDHAHRFDGAAGPAAHERMGPISLATKLDQPETYSMLNGIRQSFVVALSRIAFCSEPDWIAPERKMLASLLPALRQQAAQAAQAHKQPNDGETDAMDDMQSGDGLVDEVEETIAGLDRVSMLLEAIADVAGDLAELVLSPEEIDSIYDLLAADDDASSEHDAMDLDREPSKTRDEAESETESEPELQVGPGKRNAKSKDSVDVIEIDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH24</accession>
    <name>W3VH24_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH24"/>
    <dbReference type="HOGENOM" id="CLU_005732_2_0_1"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833151" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="421"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1114" mass="123463" checksum="CFD216C92AE91FD5" modified="2014-03-19" version="1">MKVSTAAFWGCLVCGLALLPHPFGTRAAQIPFSISTQPQRATAPATKWTLPRGSNNTAVVFDKYSLALGGGQQRLFVLAAEFHPWRLPVPSLWRDVLQKIRAAGFNTVSIYTHWGLIQPSPDAETIDLTGVNDLDFFLALAKEVGMFVIVRPGPYINAETTVGGMAPWTVKLDAVLRTNDTAWRKAWRPYIDAISRVVVKHQLVHDASRPDELHGGSVILVQADNEYKTGKAERAYMTELVAALKENGISVPITYNDPGREQNFVDLVDLYGLDSYPQRFDCSHPETWVPMRDDYLQYHMDTNPDQPFYIPEFQAGSYDPYAGPGYEACARMTNASFTRVANQALIAQRVTLLSLYMVYGGTNWGGLAEPDVYSSYDYGAALNEHRQPNDKYAELKRQAGFIAAFPDLAMTEQIADKPGLNISQVGDLDDEDASVDPATIRTTVLENPKTKSRFYVVRHNDTSVSRRTRFALHIVSQGKAEVIGARQEQEVEKRIGVNFLAGRDSHIIPVDQQLPGGLLMRWCTANVNLVTTIGDALLISLDWTPGQLVEYSLATSEDDYVESMHLLRVSEAGIEEVQGGEWDTFVAMHSDIQANPRSIRARMASGEASDRFVVYRTAKAAWIIIMFSETALTSGLFSVPARYTSGGAGLSLHRPESSLVSRFFGHSEDSVVVMHVDMLRNATYASTDSPLDTLYLCGSLSRESHTALNALPDLKYVYWNGERIDAQADEVSRRFYRIHLPGPSRAALEWTPPRSDQLDWRWRDSMPEASAAFDDSSWVQANKTKSANPYTRDPSLDTQGVILFASEYGFHANNIVWRGRFATPSHTQDVPRDVNIRVEGGRSSAFSMWLNGVYLGSAAADREKSAAGATFSLPGDAFQASGDNVLAVLQDHMGIEMEAGELPIGFQEQRGLEAVKLPRGIVAFNFPSLRTASRPEPKVTWRVQGNMGGEQARDTVRRSLNEGGLHAEVQGWHLPGYDASTWNDTLTHQSGRVTMHRTTFKLNVPQGSDVGVSFVFATIPEVELRAQLYVNGWQMGKFVNALGPQTVFPVHSGVLNHRGDNTLAVSVWMLGDAEQEMPTWDPRSHLKIDVAHRVSGEPRDGYVLDAPGWKKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHP0</accession>
    <name>W3VHP0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prefoldin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254796_0_0_1"/>
    <dbReference type="OrthoDB" id="2548707at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1250"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1393" mass="153050" checksum="E05ADEA405867040" modified="2014-03-19" version="1">MGSKGQQVDLMSLDVPQLLEVKKQLETEVQHLTSSFGQLKAAQAKFRSCIDSVATIKPENKDKTTLIPLTSSLYVPGKLSDLENVIVDVGTGYYVEKSTSDATKMYQEKVEFLTKNLEQLQETVLRQQENLQTTVEMIRLANFNTPRLQLTAVKSSDPIAALGFIHTARKQSTPLDFLVPPHTASMTDGRTQVMATSAEPGSIETFVHDPPFAKAKVKRLRRVHNAHPRDPFGASPDMKAPTSASSQDPIPTGHDRTSDAITGSHLHPPCVTNLGEQPPPLRSTHRLDPSLLLEYLTTSGTEAKHRIKSQLPSGLLLIDAYLLLRDSHPESLSALSTPNIYSLIRHAGRESLGGVLSLLLQDVVGPELNNPNGPPGLFQVKAGTQDRYRLLREILARCTQSNFLIHDGNILNIFTLILHDLCQIRQTDTDTSSASTIDRAYADGDSGSVQIPDTFPTGEARRLVKLALQFDRPELGPIVKALRVHLETRNPTFPTAREGAQLIAYYLQPNLRDFESGLDVVRALRDTNALAQDVIDDAVHDGRQYFDALQSAFSSVPDDAHASPSQEELEKVCLDVSLRIVGMKCLMAQRPDGGVQYRMTLESLLSSFRFDLVDSCQEIPGCDLRSLLDVPVNNIRTIIKNLLQSQNDPLSEVLSVLQRCDPRIVAMLPNTDLQEICDVGRDLETLRQATEIYALFVKAKTTARLPLQARHILARDGCLTNAEMFLILMRVLLDRGQKVGIVANLRALGVLPLTEAAVRQLNLRFTPAQRASLITLLAKAGATDDAFLLFQHWSQCRYEEGLDFDSARSVAAKFRGPDSIQVGDALMERQIRLMHESDRQVAISASCVVALVRSLCSNRRSGDADASPASETQAASEVPKGSTEEQLRRARFVIDAFVQSCTSVDWTHYRLTALAQACFLVRDVPGAFYALAQISFLRQLPDKLDITVLLGGLMHVDPDRAVRLFIQHASVPKTLTARAKQNTDAFDAEPASQTESRTHRSATLPPMKASPTLVSMLINRAIVQGRMDLADRLYKFGEMTGIKNLPGHVASIRALFLPDVAPNAVVKAIDRAHETGWKSDPGLLESLSQRLLRRAVERIGAPGEVSKQLGVGGKGGRERFALPPLKRLDLAKAAATLMRMSAQSMDVVNLKSVHLALEAINSVKTSFARPNAKTTVSSSTARQRDPEKDRLQWIGILDELVHRLRWATFFDTGNDYRHSLPLWKSSKARDGQLIPAELDDMMTLGFEGRGRKRQAAGGRGASAPRLAEATDESQHGNDASSSEGGDVSKDAALQQPRASSPNVLPAILYRRLMEAYLALADAAGAAEVAAWMRDEAGMDIAESQRAATTFVSRIKAAVRDRESDTAHESDTSNILRMLAGQQGTATTKRWWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHP3</accession>
    <name>W3VHP3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHP3"/>
    <dbReference type="HOGENOM" id="CLU_781029_0_0_1"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="220"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="355" mass="39013" checksum="3FA1FC8975F61093" modified="2014-03-19" version="1">MLHIIRLCSTDQQSFFPNASTFEAPTPNPQGASNPQEARQGPLPVEASDSLFRLQKFPRVSRAGLRKTERAPPLQDPVARPGKREPAPSAKPPGLRILPESCSMAPDGASSIVLSGDGSTSNRLAATVAGQGSDQSAYRQGFKAYSRLLDEHIESGSKPQYVLVEDVTPEQFESFVAEGKKIVGEENFFVNNTGKPEPDGHSDYLSLPHFEDFFKIDEPERFMASAHIQPASVEEVASIVKLANKYKQPLHAVSMGRNLGYGGSAVRLRGTAILDLKRMNKVLQIDEESAFCLLEPGVSYFDLYEELQRRNSQLWVDCPDIGWGSVVGNMAERGAGYTPYGDHFMQRRNGRQGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHY1</accession>
    <name>W3VHY1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHY1"/>
    <dbReference type="HOGENOM" id="CLU_003736_2_0_1"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="539"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="901"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="656"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1256"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1280" mass="139366" checksum="6DD29C441943C38C" modified="2014-03-19" version="1">MAPSALIPGSGLSATPISSSGPVWHVLKRGSSSSSASNSTADGAGYQVLRISPKMNERGDFNGTCTKEEVMTITPETPDGSCSSYFADVTDYCCAAVGGIYNATFQAVGLPDAQAMALDHPICATSNYADKSHCSSTTPVPYGVCNRNGPDTSRTVQQATSSAATNHPRTAWRWAAVLTATLACAAIQSMLARIISADYDLGHDTPPTPHPTAWNEMDLLPVMTPSQEEMISHVSPACQPASSIAPSSMASSYQQPNGPSGSAAAPGQPVDDADIVQEMYRLLGNLTRSFVPATRKKRDETKEERRARKELKDALDDMSYDIIELKAEASSSARRLEQSMVIDSLRRKITRLSADGGYESANRFSNILARLSDPAAPNQLRNLRGMLELMDALAFTSSDAGASATPASRAASRAVSSNGNRRESELKATPYTIADTPATSAPATERADAMHRRAQPAPVDSRLTSTESRPTVAKIRGEASAPIGSDTRSANLSLQKTKNQLITMSDLTRDSGHPLSKAQLVSNLRQHMGRKQIPENELLHDVIFLMQGINGRHVRFQEEFQYDAAANSGGAEAAGPTKVVRVVFNEGDAGYINAPTKRILHRLAELGQLYKRVAGFSQERSTMPASGLIMQSLCHFISNELTGFYRLVASLEAQMEPKGDGGAGSQAGSQQSGDKGLDGDGQNTPTTYVTLKRLSLWTEEMTLRFRLMSTIIESCQDAHGGSLVSLIHSYTFNGDPFIRRFTSNLLDEVSKPFFHSLSLWIYEGELQDPFREFFVELNDDPRAAGQSRSNAGAAEGDLPSFSDLEGDAASLWQNKFLFRSGMLPSFLQESFGRKIFSTGKSLNFIRQSCGDGDWVATRHTVSGAAAVLRYTDLPGLESTIERAFTSASKRLLDIFLDRFRLLEHLRALKDYLMLARGDFVDLLMSSLGPSLSRPANSLFRHNLTASLETAIRGSNAQYDDAEILRRLDARILEFSTGDTGWETFTLEYKLDSPVNTVLDSQAMVGYQTIFTHLWKIKRVELALNTSWLRLHETGTTLCRIKRGTGGGAVSDLRRESQRTMLMLSEMVHFIRQMQGFAQLEVIEYSWNDLLHFFSRRQGDLDELISSHRAYLNALIGKVLLRGGKRGSQDYLAGELRAQFDCILSFTVAADDLAHLSTREVARVEMEQGTARPTTERGARSRALAAVGATGAGSTLAAVDPAEVARIAKRLSEASTAFHERMVLIVGALEKHANLTVRDLAVRLNFNGRYEVTTAHRSGTHAATTAPRKKEATAPSTVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI86</accession>
    <name>W3VI86_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI86"/>
    <dbReference type="HOGENOM" id="CLU_312423_0_0_1"/>
    <dbReference type="OrthoDB" id="3359721at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="872" mass="94356" checksum="3BE8E09C50FA90BF" modified="2014-03-19" version="1">MVWTSSTARQLFRGPTRPDGLPPAIVAGLSSTNANEQQAAIEQLRGFVHELFFLDVNKFFLITNPITAGIICLLIVIGIPVILHRLYHKRLDLFRLERRAQGSYIVPNAINCFLLLEGLYGVLTVAFNFVVWKLFHDEMAVWVKFFPAFRSLIWIPLYIGAFLTGWGSFYTAPGALDKPSAARNKTSAKGRLPWPLIVNLSCLGTPVALIISLLPPVCLSSVKMVDAFNMYKAWDARVQALVAATAPGALVAPTAVQATSAQAYDIFYTWTRSYYFVDISYVLWAFWALLFLFFYVPAGGTLVFLLFRQVRKQKAILVSYQRKIEVQLAHEEKNATVLTGDALTAPSAPRSAGWNASGANSRGRGAALEDIYEDRGASGGSEATGHSGVTASFKGSHEMVGIDSMLRQEPPRVHGALTPGLNSRLGQVASLADEAHGESNLTAAEMTPPVSPRSPSMLRRLISATSSTHKLGTSTHKRARRVSITGGPMSRYKYLRRCLVNLLILYLGIISAACFFGAVTIYLAAVEYEHALQGPEAVAESIAIAGATAAWVSAVFGVLTIGSIIFRNFDNPQPEASQGSGGDGALRKRFHRNASRTLESGEAQGGVGRGAHDKTRTLPAVPESVDIEASMVSRSRPHMAHDMSMKFAMGEGHGGFVMRPDDQLASAMSVGNTPEIEVAPSGGRAQGQQGAALRPLGPPARAWLGREREATMSIPQDVTESFGLYSLPMLTRPGEAAPVDAVEGHETVADSTLREYPSFDPQLMRSVDQETALDAAPISPRDTSYRKPVSRGGSPVLKRHARLPDSVGSETPASRIAREWAQSQYLATPLPEPPARGDAAGWVDDMDSAPLSPPVSPPSSPPRPKRDHRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIE1</accession>
    <name>W3VIE1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_05231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIE1"/>
    <dbReference type="HOGENOM" id="CLU_010316_1_0_1"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="4">
        <location>
            <begin position="132"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="3">
        <location>
            <begin position="568"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="2">
        <location>
            <begin position="762"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="993" mass="107840" checksum="642E71A9199D2F5B" modified="2014-03-19" version="1">MATTDAAPATNGASSPEQAQAQAQAAAVQVPNSPSSAFAALTLDDAAPSSSSSHFTPAHRAEIDAATKLVAALDAARKQPKPLIRSTGHRVDVPAGVASNTGADHHHLLSWKVAEFAYRKATGVGSELPTLARGLFTERVDTGSDAAEKHRIVVRGYDKFFNLGEMPWTKPPSIERFTTAPYVLTFKENGCIIFVAALSASHIVATSKHSLGGLAGAEVTHAQKGREWLLKHLASVGRTESQLAAELWRRNETAAFELCDDDFEEHVLAYDRARSGLHLHGLNANAAKFATRPMPDVDAFAEAWGFIRTRWIELPSLQEVQRVTAEIEQTGAWEGEPIEGFVIRTHMPAPHQLETIKADPDNTAVSPPYAPGQAWFYKVKFDEPYLMYRDWRELARKMLKEKEDWQAKVAATQQPTSDSTPAAEPDKVEEPGTKAEEPAEQANERGGEGPSKAALKREKKRLAKQNAKEAATARAAAQAAGILPPSPPQPRARRPETLAFIEWCYDRLYGNASKSIAPQPSLFAGLTQNKGIIAMRNAFLAHLASAAPVAAAAPAEKQPDTRAFSKTVLAPVAVPGCGKTVLAVALHELFGVSHVQSDEFKAKKGFLGAVERDIRAHATESHVVFADKNNHLQQHRDDMVELARQLSIPPAGPQGKKGKAKVDVGRVRTVALVWDLDSVPLNTLHRLCAARIEARGDNHQTLVADTAEGAVAGMRSHEQILWRFLEALEPFHSAHGKGEGSQGYGDASFDHVVQLSVRASAKDNLLTIIKAMGPVLGWSVPGDARVEAALAKAVDWKVTKKSRADKKDEAGVRYFGLAVELDVRATLDSLFAGREDEAAQFYTSVRDGGRVNARPHVTLVHGSNRAAEGEDKNASDAKWDFYTRLLSNASPIGTLGTVGGGTFEVELSTVLYERDTLLTFPIDRITPPRELADEFAVLHTDWYPHITIATRDAEVRPYLAHSVVQHWRERGSKAVELKLGTPVVAEARVFGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIF0</accession>
    <name>W3VIF0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIF0"/>
    <dbReference type="HOGENOM" id="CLU_414537_0_0_1"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="662" mass="70786" checksum="22074042544553A3" modified="2014-03-19" version="1">MGAKRMPKVTSLASSSTSATAPQQRRANAFGPVDPSSYHDFDEAMQDGVELEEKGERFQFGSKAQRFYDQAGTLYARAARLAATDPTRRADALYNASRIQFLLATQFSLPPNNLSLLVEAVNMAEQAAQLAPPLVDADTADAPLPNPFTLDALTHLATCLQTLGEAVQELGWPPELRPPSLLHRQPSRATTPALLWQEASALFQRVAHGQAAILKDQKLADDASVEPGESGMLEPEQQLPQQDQVEASEEDQDDVYGYTSSLVTPPALVETLLSLMACLISLVEVAPSLQELQTRNAAAEQVAARVHETISDSMTSDKSSADGALLASSSEEMRAKSGELERTLLALRVARIAKAIELGTEAVQLSDELESAMQAVHDWATRLVAPPAADQGSQVRQDLDVPTLCDVGEAGQNLCRLSLRLEPAPNAVAAIWTLATLSTKLYSQALSALDTASRGGGSAAVLGQANTSTPTSRARCRILLALSSFSLFRSHPAFEAAGIPGAMGTRSKLIDNARLYARKAATEIGLGWILRPAASRAPTAAVQPPPGGWESLSLEAEVSMHLLRALLFRARANAAGMSDGGAATEMQNELAQLIQHLIQLRQRPIQTDLTASASSTQLAQFMYGQGVKTFVDGIVDDHGRNVVQDEIPWWTELLSGPLASVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIG7</accession>
    <name>W3VIG7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIG7"/>
    <dbReference type="HOGENOM" id="CLU_023313_0_0_1"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003976">
        <property type="term" value="F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046835">
        <property type="term" value="P:carbohydrate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="660" mass="72791" checksum="7281F7D1485A4036" modified="2014-03-19" version="1">MTQRATSSIRSLRQLRTRTVLLAGAVVVALVYFTNAYYHRNVMAEHASWIPTTPGQASSQAAEEADVRRRSACWEQWFSKGTVCVRPPKQWTEQVKLDLVWTWSNSSLTRQAHDRIDPAKTSSSHSHAEASDFLRYSFRSAQQHMHYGFGRVTLLTPDLPKDKLATQPLEACTRSYQDAQGVSRSGQRPCWLATEDRVFEAPQLLHNRQVGCAPGSSASSCSGHWIDQDEPFSSALLAAQAPGLSDVRLLVAPHHVFARPVSASDFWSPLYGATYRFDPEAQVSSAAASPTAGEEALQKPNALLDARFGVRPRRKLLDLPVPVSASILTEMRQIWPGVLKLTPTSQSAKFDFGFLAAHYVFERHREALLWSFVVAKHDRDADGLLSAAEAEAVLKDLGIDAHKAYAAPQVELPRRGTRSAATVVSNLRRAQMPERLGKESMSSSMDGLAFLTPRSSDAQEGAAADEVQPPVCRLDRECVKPLLDAMSGSDPPRVSEVLRRVTFQAPMCGDCMLTHLVGQSGEQGLSAFLPAGELEMPAIEVLPLTARFEQADYSLSGSGAARTTRLHGVTQLLARYAHTVVQQQSFVTPAMATLSQARLGLITLEVLESSSLFSFKQQLNASEPLELAAQTEWDWTAYVRAWLSLRFPFAMRFESRTDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIR8</accession>
    <name>W3VIR8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIR8"/>
    <dbReference type="HOGENOM" id="CLU_903518_0_0_1"/>
    <dbReference type="OrthoDB" id="10396907at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="308" mass="33049" checksum="BFEABE3313A1FB17" modified="2014-03-19" version="1">MRKSGTAGRGPSEAAQQRAEKPRHGFGPPCGRESTLVATGRVCGRGSMRGENARARPGGGKPDREAQPTRGGCTRRTLRTSNCDHRNPALVLACAKPTRVLTTTAAQHCPRHRGPPPPTKKITKKNTTAAAASAAAAAKRESTAVSTSTCNFHTPPAARSPEWLKVHPPPPRRPSSSARQQHAAAMHDQPARFRCKPTNQLGWPGRCLRLSTELAASAIGRSESRCAVRVADTFSAPKLAEPPNRLLFARRPGVVPRLLHDSQAGPARLIVATAADSRTNNRHNDNYRRATRAAPSDPNLADEGWQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIT6</accession>
    <name>W3VIT6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIT6"/>
    <dbReference type="HOGENOM" id="CLU_007884_8_0_1"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF193">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="414" mass="43928" checksum="A78E9117DC3F3223" modified="2014-03-19" version="1">MTLSTLSGSAPAERVVIVGAGIVGSCLAHILATHPCKDRIILIDRDVEGLPGSTGHAPGYVGQYNQIPALTTLAVRTVRKYLDIPGGFSTVGGLEIAQSDQGARSLEQRCTAAKGAGLSAEIISTHTAVEKAPFFVRSPESGDGIGALWFHNDGTANAQHIARHEQQQARSKGALLLNADVCAIESNESLHTLVLKDGSRIEAGKVVVCAGIWTRDLLGSLPVVPVAHPYAYTAAREPRSLKTPFVRYPEAHVYVRDHGTQDGIGSYAHDPIAVANSSLTSSAYGAWHTAFEPVLQDALSLLPDEIARQFEVSPESAGAERVFNGIFSVTPDGMPLVGQVGQGLFVASAVWVTHAAASAQLVADILTGQLKQEDQWLAKQLDPLRFTGKDASTLERTALGTYNDIYNKNASISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIX6</accession>
    <name>W3VIX6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIX6"/>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="364" mass="40047" checksum="711F6276BB5FD295" modified="2014-03-19" version="1">MPAIQPKSHVLVTGGSGFIAVWCVYQLLERGHKVRTTVRSDAKGKYLQDLFKKYGDQLSFVIAEDLEKQGAFDDAVKGVDAVLHTASPFHFNIEGDPRGTLINPAVNGTRNVLTSIHKHGKDVKRVVITSSFAAILDSTRKGHIVYTEKDWNISSVENVEKQGKDQEGPDAYRASKTMAERAAWQFVEENKPEWDLVTINPPLVLGPILHQVAAPEKLNTSVGFVWGLLHGSKKEDDLLAPSGNCVDVRDVAYAHVEALVRADAGGNRFATSLGPFVWQDVADVIHADDAVPSEWKKQVPQGKHGEGSSVKQNELDGSKATRVLDLRYIQMQDVVKDMVASLADYEKRGWSGVPSDHLLSLTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIZ4</accession>
    <name>W3VIZ4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIZ4"/>
    <dbReference type="HOGENOM" id="CLU_1750480_0_0_1"/>
    <dbReference type="OrthoDB" id="10258202at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="149" mass="15476" checksum="FC4700BB07EBE45A" modified="2014-03-19" version="1">MDTNSSSSGSRGWSGPSRGHRPPRGGGGGGRGGRGGRGGVRGRGGGWNGQHRDGRQAATPNNTTTDTQLAPGQPHPGFFHESFVGNPWYDLEEKLGIPHVPAVSPNQTPSSQPDDVIESSTTIDAQDEARAQSVKDQVSSTVDAQPAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ15</accession>
    <name>W3VJ15_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ15"/>
    <dbReference type="HOGENOM" id="CLU_053380_9_0_1"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="424" mass="44090" checksum="2C69F55862CCC77F" modified="2014-03-19" version="1">MKWLKAGATASVGGCGAEGGSLSVMDREEMNLAERLKVKVQHFARSCNRDACQVGSPDGSTFCSRSDPVPLHPAPSILTSSRRTSKTRPLCKLRKLRTRSDSKETAQEVLSAHRRSSATHYGQASVRPGGPTSPTPSQSSGFASLGASIQRATASAPSVAANDVPLAPQRPGAPSLPGVTRTTASTDAGASTSATATAGPSAPRAAVEHRSTATAAIDPSATELLPTATAAIDPSATELLPFDEQAKLVYGVVFSLRNMVRKLGGDAETFNSFTTSTYTLAHLHTPTMYTLVIVTDPVPPPSSIPSRTSDGFAIGSASAALSGRSSFGTGGGIPGTGGMSLKGVLLQIYRGPWVDGVVRNPLLRAFEREERIVDPDADAHNPAQAGVAVVSERRIDRTHGIDTDAFREGLEKVLVQNKLSAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ22</accession>
    <name>W3VJ22_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 8">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04267</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 8"/>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ22"/>
    <dbReference type="HOGENOM" id="CLU_005948_0_0_1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="101"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="529"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="598"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="769"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1179"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1228"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="784"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1181"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1253"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1270" mass="134640" checksum="3679556A5CD70E90" modified="2014-03-19" version="1">MPAPHATPSSPPPHASSSAQKTPPPPPSPSSSSSVVHQVGSRQGTRTRTRTRRNMSSSANASHRTPRYTNEDHPMAPHNLAERGYHSFRCLGVPFHVKQRYTFVRELGIGAYGCVALCRDEVLDCNVAIKKVTRIFEKDVLARRALREVALLRHIGMCDNVTALLDFDTAFIDFSEIYLVLSASEADLSQIIRSGQSLSDAHHQYFMAQILRGVRYMHAAKVIHRDLKPSNLLVNGDCALRICDFGLARAYADSDEFHAPTASGEEAAEPKPRTSLSSSVDGDRSDTQAIAQEAASSTAPRSDSARSPSPASDLHVQLYKTDSKGKQKRLNYPGGPLTGYVATRWYRAPEVMLCFREGYGPEMDMWSVGCILAELIAGAPIFGGKDYVDQIARINNVLGSPSDAVLDKIGSERAKTYIKSLPNMPAVPLEKLYPNANRDALDLVAKLLTWDPDERLTAEEALQHPWLKAYHESNARWQSPQPFDKFADVEFIHSLRQFKSSLQREADEMRMELEELEREELESLGAHADLPHADANGNGAQHTPPQPDTAADSNSNGEHENAAAAAAPADSESGNVQRADDAVEKQAQHELCRVEADAQPSDAPGPFHAADQEAGAETDSADALSCNASSQSGHLPADAASSSSSAHTPSSTSGASADEAEPPSPRLYETCGLSATALKSRAEHLEEGKALRKPPAFFRLGHEVEGRLLSHLASAAHADDEVSNDAFMPTQVLTVARGLVEYQSSHAAALAARESTLLPSCDAASVSHATHTKHATSPGPVAVTQAAASGGTGGSTSQSSSGSASASRAQGGSRAAGAASTSSIGQSLLDDVMFAPAEGASSGLKSVSSQRQGKQLVVVQDSVVQSSVQLLRELVRRAALRKHTVVLVAALRRPETYLDALGDGAVATIDATGLGDVYTDDASALSSVEQLRERLRSELGRLGSGAAKTMVVVDSLNAVVRASSVAQASGLVRETLGGMGASSRLVVGMQTGGVEASTCAGLVAALHSPLIWGSASTAGTVLTATLHAPALVRHLFKQYGLRPPSSSGRDGEDEVDARFWEVLRNVSARGPMGIAAYEAGGGAQGWWSDGAGEACAFEPLSARVEPGLSTANGASGGATRFAGAVTLADVLDASRDGYALLELHLQARNGKKHDELGALSLGSDGELRLLELDMTDRRSEAGAATPAGTPDAAGGDKHSTMVSTLPFNLGETEAQRVRREEVPLPYAYHQNVGEQEQRALRGNTGSAKIFFEPEQDDDEDDEDPDDDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ50</accession>
    <name>W3VJ50_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ50"/>
    <dbReference type="HOGENOM" id="CLU_276825_0_0_1"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="789"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1045" mass="113076" checksum="E0D95E516F0607C3" modified="2014-03-19" version="1">MSSGSNRKGLLPTSQDPSKAPANPANNPPPQVQRRSSQPLPGISATASSLRSRRAGSTSAGSASSNPKQLVELDDNDFDDETPGEFDPGMHPSSTTHRSNRANIPANILRAVVPGSSQAPQNKTGHASSGSAPKKPSPAAPLSPPPTSSNRFKGTPARSTRYSLPVRTEKPVRTTKTSGKHVVLPSESQLAPLPGDEDEDDDDDDDDDDDDDESGDEEEVTDDEDDALPAPSAKPGAAVAQDGKAEAQAVLLGGRGVGRALESVGASKPPAKVPVTTPRPGLSIPSNRHSAPAPVPGKLVTPASKASQRTAASSALARAAVSSVSAAQARHAQKHKPKASSTFRGAAIRAPPLRPHKSGPVYHTFERMPPSARLMTPLPRLTAYSISTSIHLGTLLGFLRREHGVKPRLYDECAYAVYTKPLLPGFGRANVRSAPEPRSASPGAESRRERELEQREEFGYLGTYFEHRTEEEEDIDQDGYIKGGEGRGSDSETRRRGDSHRNDGRGGGETSAWESEAERWNPNERRNSGGMDERETQQSGNGQDAHHHTRNKSNDSNTAPVSSSLEDDERMLATPLARPAAATRKLSDSDAEVGGEARPFLLERRRAGSQSSVSDVEALPPYRRSGSPVEVETDKNELVINHVDSAGARDMMLQQRAEERGEPEPMAHSYRSNEMSMTSDLDDAANHSREHAAAQHDGTQDSLPSRDGGGASDRIEGNGGDEGSRGAGDETTLSVEAPAEEQRRTRKVKLRRRKRRYAGPNMASHNHDTSANLNTPRPILEALQSAELVILPYGVLVMYNFSAAEERSIIEDVLSSGCAREPMDEAARESEAFHFCYDPNISAPRIFNDFFTFRAPNHLLKLSLAHAIAQSTKLSVFEERMQATLELTSHIPKEMASSGELKLKRREALRLTGRLFKLRVDVNLTSNVLDTPELFWSEASLKLLYDAIRDYLEIDERVENLNERLAVANDLLEIIHEHIANTAMSKITWIVIILIIVACAVAVGEISARFIVGANRSAEDGLRALRAVAAPALPPATYFALPDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJA2</accession>
    <name>W3VJA2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJA2"/>
    <dbReference type="HOGENOM" id="CLU_478266_0_0_1"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000120">
        <property type="entry name" value="MAP kinase phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF530">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0271350-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="364"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="433"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="606" mass="64586" checksum="36F06D93FF492D25" modified="2014-03-19" version="1">MGKRRLSSIVTTVVRSHKLHHSNGARVSLSPTTLDPNPDWDTIQGVHQDVPTMATGTAGRSLDGLVKGAAISTESFWSADLPVWRSGEAQHSEAGPSRSSSIHSRRGTCTPTTLTPSSPTANKLLSPPFDVVSTRLAPSNEPTPPTTYRSAQHLDGQSAADLECTGAPLLSGFQMAGLSASPEQVATSSSARSHPSHASTIPSALSLNRSTAIPALWSTPSSLQSDPVAAPHPSRPARPTLARLNTSEMLRTQNASSAASGAVPSTPAIVRKSPSSLKLQLDTSVPRRSATLSSFPHAAKPRFAIPTMEVPRSHHSVKSHGLDALLSSTSDAPDQPRNSNRDAASTLESHQPRTEVIGEDFAFEMSTILPDFLYLGSNVQSENDVAELQAKGVHRILNVACEIDESGPLQLRQRFRRYLKLPMLDSVEAQGVQDNIKQACDFLDDARLRSEPVYVHCRAGKSRSVTIVIAYLIHALRWPLARSYSYVVERRAASSPNIGFVAELMKFEEAELKLARSTGIYGDAPGSSPSQAFPAASDGLTGPAGVGSQHAQARPHQSTPMLAPHGTDTPRTRTSHDLSAPESDHIRGGTLSQSSPDLPSLAFGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJA7</accession>
    <name>W3VJA7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJA7"/>
    <dbReference type="HOGENOM" id="CLU_060161_2_0_1"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="238" mass="25616" checksum="A8231BFB313009F3" modified="2014-03-19" version="1">MAFGGVALPGSGSTNGANGIKGQPSSGALPKGNGAGDDDKKVANVGKDAGLDQGISGVHGIVPTLQNIVATVNLEVRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSRLASRKYARIIQKLGFEAKFSEFKIQNIVGSCDVRFPIRLEGLAYSHGVYSSYEPELFPGLIYRMVKPKVVLLIFVSGKIVLTGAKVREEIYQAFNLILPVLAEFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJF7</accession>
    <name>W3VJF7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJF7"/>
    <dbReference type="HOGENOM" id="CLU_010127_3_0_1"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="375"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="428"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="768"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="635"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="727"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="855"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="639"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1078" mass="112481" checksum="CB775503D78417D9" modified="2014-03-19" version="1">MLATLFRHGRAIRRLDSLNSSPSAVLNNIKLSRSCAGAEPALAAKGSQKQSKAKACMRIRSQCVTLATNEFALSTVTSAKSLQRGTIRPSPREERVTKAGAAPTTPPCCRSPLCTEFFHCEVATLRNALVQTTKPFSSVASRCANPRLPLARLTRRGKTAGSSVTQISHFHRPTVHFAPLSRSLSLSPALGVEAIFPRASQPASSLSAWNIRAARPTRSPSRIAYAALAASAHSARADDDDTAAWHHPRCGFLRHRLALRSHSNQRAQPDDQNPPPAEASQQVTMVRSVTFEIRWHDTQPIYSCSFQPIPANHLRRVLDHNMGQAAGMAPGKGLSELDSSAAAAMTSTSSSHASASTSAASSSKLAHPPVMAGGQSWRLATAGGDNNARVWMVHPNIPSPAAIASAAAVSGSTVVAPHPPRVEYLATLQRHSGVVNVVRFCPKGELLATAGDDGNVLFWVPSDRSKPSFGDVSTNLEGETQFEKEFWRVKLMCRATQQELYDMAWSPNGETLAVGGTDFVARIINVQDGHVIREISEHNHYVQGIAWDPLNEFIATQSSDRSVHVHNLQTRRHGDHAHGHATGTDGVASSQLVSKNAKLDLHRRNGSSGGLPAAASAASAAAAAAAHDHMLPVPAGLASSDAGRRGSSVSRSGSRTRSIRSPSPIPPLPAIRAPPSPKQRMQAAAASGLGGPLAKASMRLYGDENFSGFFRRLSFSPDGGLLVTPSGLFDPPPPPASPTVSLSPRKSPATLNPATVAGGAQPAPTAGAQTGGANKSAVYLYARGNLTRSNAPIAVLPGHKTATLVVRFSPILYELRRTPRAGSGAAAGDDEGIAPHPTIPLEAGKQKTVSLRTEAAMAGSPPPSGVSGAGKASPPVSRQDARSPPRGISVIGLPYRMVYAVATQDSVWIYDTQQTGPICCFSNMHYASFTDLSWSPDGQTLMMSSTDGYCSVVVFDYAELGVPYAFAAQPALKAPAPGVPAPAHIAEGKTTGSAPSTPKITSPAQLVSVPVQAAGSAAEAYASAIGGTATATTSAPAVASGAGLGLAIPSAAGADTGADEAPKKKRRIALTLERPLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJV6</accession>
    <name>W3VJV6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJV6"/>
    <dbReference type="HOGENOM" id="CLU_020027_11_1_1"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="18"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="401" mass="44082" checksum="37461994E8D19288" modified="2014-03-19" version="1">MSMQDTVQKVLDAATADITQPNAVPGAVMYIADKTGKQVAWAAAGVKQAGKPDPMTPDSVFWVASCTKLITAIACLQLVEQGKLNLQDDVTKYLPEMAEVKMIDGSKPKRVPTVWNCLTHTCGLGYSFFNPALKALEDKKGRKVIDAFDASKESIMGPYVTEPGSEWEYGMGIDWAGQVVERVSGLSLNDYFQKHIFAPLGIKNASFLPKTAGLADKLVGSHYRNPEGIISPNEHWLKQEESKIEVHYGGAGLWANAAEYCQILVALLNRGTHPKTGGKILNPESVEELIKPQLDEKLAADMDREFPNTDPTLTNYFEGCTVKGVPKNWALGGMRLTVEHPMFKYSDKSLFWCGIQNSYWWADFKDGTCGMIQSQIGPFLDMGTLGILAQIQPQVHAAYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJX7</accession>
    <name>W3VJX7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Siderophore biosynthesis regulatory protein urbs1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJX7"/>
    <dbReference type="HOGENOM" id="CLU_010093_0_0_1"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF335">
        <property type="entry name" value="IRON-SENSING TRANSCRIPTIONAL REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="323"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="469"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="529"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="599"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="798"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="902"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="974"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="710"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1014" mass="108563" checksum="4A81D2D4B9D7E08F" modified="2014-03-19" version="1">MAHPLVKIASRPASPTPSHHQPAASSSSSSSSSHPQRIAARPIAPADRSPERYSHHARAGSLHDQEGLHHILPRTSRPPSPSAHHDVSQIPTRSTARSLFRDPRSFHPAGRSQSPIAAFRNRSQSSERSHLGPSRSQPNSPLLHPSSFRHPNEAGGLHLPPISSLSKELISDHPDALAHRRTPNTSPRAAARLHMGNTFRDSSPAPSSGSPATMRHDHPAYRHEYPGEDRHKTHRYADDQPRAIAPAPRPSYDHEIRAAHYRDAQPGSSRSNELPYHVNGSRHAYSEDPRPHAHTQPSRNPSPQHTPRDSHEHEASGSPPSAHHAGLRCSNCGVTSTPLWRRAPDGSTICNACGLYMKSHSTNRAASSRASATDASPPAQDPKALPPASGCSRDDDPKSGSCPGDGLCNGTGGTASCSGCPAYNNNLSHALKVSKREPRAAEELSPARSNAERAPAAPEEKKEDDKSNGVGALRCTNCQTTTTPLWRRDEDGNNICNACGLYHKLHGTHRPIGMKKTVIKRRKRIPANATAQAANQTDAAPVQVNSNGQPIIAPAAGRAGESTPGSEAKRASKKSAPVSEQALREARDREAAMLLMEVGAGARSREDPRHQSNAGLSSSASMQHDLASARSGGDAAHMAHLDGARAAKRPRKSLPLASREAYDEHDGSNASSPSYPDAQARRRRADVPGASEQAARGSVSDAGRTASAAPHHHHHHHHHHATHSAHSAHHGHHHHHHHPVAVNGHVAHVPAGSTKISDVERLRDELLFERKRIDEVLHRAEAILAAARQSNLGADAAAPAPSVLHNGHGHARESPPRGSSARTSPVADGRPTRVNLPLKDSHAYDNGSSSSEKDELESPPPTHQQPAGRPLLAPSDSQPASRRSSFEQRMASLPVMAAVPLKRNSPPVSAPPAARKATAWGIDARSPPVGAAARQGDKRPRPDDMDEDDDVYNWENLYGKAKLEKAGDWRGFARPVEDRSQAQSRSAAAFRREGAASRPPAITNSAQPVGAPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJZ5</accession>
    <name>W3VJZ5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJZ5"/>
    <dbReference type="HOGENOM" id="CLU_336188_0_0_1"/>
    <dbReference type="OrthoDB" id="2555144at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="848" mass="86707" checksum="C6C57E92641B79C8" modified="2014-03-19" version="1">MASSTSDLVMSVEPMAVPLPTSPETSIQEVLVGPSDPSSLADASAQHPSERSDQPTVGTTDTLLLSPARKAVSLAGDAAPPKPMSPEKAALAAMFDSIKMPPPVSSPTKSPRKASNHLLTSPSKGGCGLFGASSSPSKVDSTDSAASRSPMRCPVVIRSSSPGLGHLTTNEDKKASTPLSPAPTSSASSQHAGRSWLVAPSSPSAKLSDLSLVLDTTGTQELLFNQDASFLAAAANSAADVTIDDSFDVSRAKARIRSASTAAPGPRHRSSPAKLGALRAKPRFSTVPEDAAAEFKPRTASQADSNSLGLRNLGVGRVVKNAAGDDTIELNLTGSFMGNSSLVLGNLMDESGEASLLFGNNSFSISQSRSPVRAEKQQELAKVRGGARRSKDDEEDDDDDENEDYEREARDVQKWAAEAARKAQQTRVSTLADKTPSRFVGRTPTTAAASRAAPPVPAARATPRASLTAPAAASRLAKPRTSAVAIRPVTDGEARLIRSGSASSVLSLSSPARSTTSTRASMPGGSADEPGSEAKTPMRSRRKSTFTSSRPPVSGPARRRESLAAAAGVPVPQPLPPVPSLVATTPGRSRPATVARVASNSPSLKTPTATARMAKPRPSLTGATPRASAAPSVAGSIPRPRASLTGRMSLGPAQAEEAKTPAPRAGQIRSASLVTPSARAAARSVQADATPLGGMRKSASQPQGLDATGDATPAALGARARTLVPRASMSRIGTAPPAAAARSSLLTTPRSVRPAAVEASRVRTSARAEALVERTANAADADALRTPLASSKVVTVSKIAAPAAGRPTTTARTPASGGFGFKPRTSAVFVGSARTASASHTSGENKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK51</accession>
    <name>W3VK51_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK51"/>
    <dbReference type="HOGENOM" id="CLU_019134_3_0_1"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="9">
        <location>
            <begin position="213"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="10">
        <location>
            <begin position="376"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="692"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS61131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="756" mass="80095" checksum="B1548B63E41C15FD" modified="2014-03-19" version="1">MSTSDEALVLCLYAGGTIGMVRKDASSGFAPYPSFLTETLRSQSRFHDPHGDSIFSWSDSVDRYKAWSEAYTRPGSGASTPLHAKDTTALPSESTLAKAVADKSANTSLLDVNGAQPSKKRKSDHDTAPLTPSTQAHLDHLFADSASRSPSGAASAGAPPFGHPVLVRSSAPKGTSTHHALSSSVSADGEHLELQLPTLITPRGGAHSKRVRYAVLEYDPLLDSSEMDIPDWIRLASDISLNYQNFDAFIVLHGTDTMAYTASALSMLLENLGKSVIVTGAQVPLSELRNDAIENVLGALMLAGSYIIPEVGLYFASTLYRGNRTSKVSNNALAAFDSPNMAPLARVGINIEVAWNLVERSRSVKSFRAHDRMSPNVAVLRLFPGLPTSTVKSFLSPPLEGVILESYGAGNAPSRPDLLEVFKQASDRGLVIVNITQCVQGEVSAIYAVGKKLEAVGVVAGGDMTPECALAKLSYLLAKGLEPAEIRELMGRPLRGELTSSRGGAAQALPQELTPAAKPIKADVRTLLAHILQNPSKTQVAASAPSPDKSRSGVETTSRDVRAAAWDSSEHEVSAAAMAVLPWLIYEAASKNDVALLQWHIYALAQLETVPTISIDEEHFHPSTLHPAASGGASGEAAATSHIVGESVANPEATTPIEKLQPLHVASAKGFTGVVELLLQAGCSVHARETTSGHSPLFLACQHGHAATAKLLRDAGAHLKEDELALARFTVSQQRQRDPSTPDTAAIWQLAGVTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKB0</accession>
    <name>W3VKB0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
        <name evidence="14" type="ORF">PaG_03663</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKB0"/>
    <dbReference type="HOGENOM" id="CLU_1012385_0_0_1"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="275" mass="29902" checksum="C995766C720B63AA" modified="2014-03-19" version="1">MPRLHNAGSEMRTLPTAYISNRERKVAATEPAEDRHADRLARDSDQSRDPPSSFRGQRSGNGNGKLQPAFILQHPSRPAFSTPSSLDPEAITCSVLDQRTPRFSSAQQQERQGPISAHCDLARLKATMDAQDIVSNIAFTTSGSLVDCVDKKMLVVLRDGKKLIGVLRSYDQFANLVLQDTVERVFVGNRYGDIARGVFLVRGENVVLMGEIDLDAEDEVPPSIAAPLPPSALPQLLAAKEAEAESKAKSEAKKADVLRIARGFCADKSGDGDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKC5</accession>
    <name>W3VKC5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKC5"/>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="99"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="216"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="612" mass="65346" checksum="C77CA70FB58C42B7" modified="2014-03-19" version="1">MRTSRLLRTTTSSLLARPQATTAAARLAPSLPALPALSAASRTMTRVKTANARLSQVSRQFSSSASMSASAPKSGAGAGANAALDDNKLVKLLSEGGLRTILLNREKALNALNQEMVDLIDAALDECIQAAACNVILLRGTGRALCSGGDVLAVVKAADSADAKVRNTALDFFQSEFQLDYKIARLGEAANAHSAGKGAEDARTLTKSKGGELKKPKTFVSVMDGITMGGGVGLSVHAPFRVATERTMFAMPETGIGYFPDVGVTRVLARLDGRIGQYLGMTGARISGEEAYLVGLATHYVASGNIDALAHRLSTLPAESALNPSLVSQALHEFDADPLAANETLAKSAFFGDRRIALDYVFGQLSCESIFSCLDEIAAGKTDSQAAVELAELGLAHITPEVQAWAQQTLKDLKTKSPRALKITHQAILEARRFDVEEAFRFDMRLATAFCDFSIGRDFYTGVTHVLERDPATGKRRTGIAAWDPPSLDKVSDTQIRAQFFSDLDTARKAGLQMDVPELPSVPAPATSKEARQARDSLLRGKGPLRWEQSHNVFALPSEAECAALLEGNHPAAAAVTPDSAELIDCLKRHKGHLPGLEFKVADWIKRSHRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKM8</accession>
    <name>W3VKM8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKM8"/>
    <dbReference type="HOGENOM" id="CLU_060216_5_0_1"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="121"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="7">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="273" mass="29532" checksum="CC0E1A307FF4B08D" modified="2014-03-19" version="1">MGDSDGQCSPEEEEEAKRKMVNVLKSALVKKGLRPVLPVVFSPSHRYTTMFARTAIPAFRAASKRAFSTQAAGVAGNASARRYMGAATLVAGGALAYSAFAAPSVHLEGPKTIAGELGTATERSYVMIKPDGVSRQIVGEIIARFERRGYKLVALKSVIPSQDLAKEHYIDLAKKPFYAGLVSYITCGTPVIAMVWEGKDVIRQGRRLVGATNPQDAAPGSIRGDYCVSVGRNIIHASDSHESATKEIGLWFHEKELATEYKPIAWDMIMADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKU5</accession>
    <name>W3VKU5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKU5"/>
    <dbReference type="HOGENOM" id="CLU_040201_0_0_1"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="249" mass="27445" checksum="1D5F4D075F715C94" modified="2014-03-19" version="1">MSTRIPLSSRQQLVPQIIKSHRRKDTDGLSAWLLLIWVAGSIPQGTYLVVQNINIPLIVQPQLFSTFAIIAMAQCWHYSHGIALRKCIAAGVVTGAVAGGLETAFYFLCKLGQDRGTSAATKTMGIVGAVLIVLGLVPQYYEIWRWREVKGISLWFLAIDCAGGVFSLLSLVFKAEFDGIAAANYIGIVVLELGIFALYFTLNPRAERRRQELPSEATTESTALQQGAEETPDWSRHTTLEKPPQEHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKV4</accession>
    <name>W3VKV4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_04469</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKV4"/>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="77"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="163"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="428"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS61437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="624" mass="65511" checksum="C88B455B7E5A517D" modified="2014-03-19" version="1">MLRSTAALRPSAGPLLRNVALSLRRNLSSSAALRAERAAPGALNKYSRIITKPKDQGASQAMLYATEGIENDEDLTRAMVGIGSIWYEGNPCNAHLLAISQRVKKSVQEAGLTGYQFGAVGVSDGISMGTDAMSYSLPSRDLIADSVESACGGHWLDGAVSACGGHWLDGAVVIPGCDKNMPGVLMALGRLNRPGIMLYGGTIRPGGCASVSGTLDIVSAFQSYGQYLANGGTPDAEKIRYDTVRNACPGPGACGGMYTANTMASCAEALGMTLPGSSSFPAEYPEKIAEAESMGAAMRLILEKDIKPRDIMTRGAFEDAIALTMVLGGSTNAVLHLIAVAHSVGIKLDIDEFQRIADATPFLANLKPSGAYVMEDVHSKLGGIPTVIQYCIENKLMKGEHMTVTGRTLAENVDRWTHARGKLPAGQDVLRTVDKPLKSTGHIRILKGNLAPGGAVAKITGKEGLSFTGKARVFDTEDAMVAAVEKGEIKKGEKTVIVLRYKGPQGGPGMPEMLKPTSLIMGAGLGQDVACLTDGRFSGGSHGFVIGHVVPEAQVGGPIGLVHDGDVISIDAETNTLELVGVSEAELEKRRAAWKPLPLKPKSGHLLKFVRNVADASHGCITDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKY0</accession>
    <name>W3VKY0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell division control protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKY0"/>
    <dbReference type="HOGENOM" id="CLU_005871_3_0_1"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="82702" checksum="B029485FC4014D78" modified="2014-03-19" version="1">MLASLFLQDDIPHRIVPVDGYRSLTNTLADVFPPLTDDDDAAANVASTSTAAAAAAAAAAATTTDVRSVVLINLGAVLSLPTMFNIPPSCTLHVIDSHRPWNLDNLFATSHANDRVWCWDDGDIATKLCRQGGERDAFEKLEFDIDSDDDDDNDDSGDESHSDASGSDSDAPGDAGKRKRSSRSPSRSASADADASDADLANAARKRRRHPSHHPASARLTNAERHRYRTLLTRYYNRGESYGMSTSSMLYLLCESLGRADRESLWLAIVGLTSLYLSHAIDFETYEAYSSAYASEVIAIEPSTSHPRSEAWSLDLLAKDDSADKAAPRGDRALRAGIAHNTKSEDADDRTIRIIPAELRFTLYRHWSLETAMLHTAYVAAKLGFWRERGQAKLRGLMAKMGFSLTAVRQNYTHMPLDLRRSLAVKLDAIAPEYGLTELSYRGFERSYGFQTAPLGAADVVEGISALLVAAHGVKIEVETPGMVFASASAGTPLSTSYAANRGGGPATSELFATKRAWNLGTHLTDAVSAATAATSSTARDATGANSGLDLEPVSSGRASGDELVQLEQAERHVWVNNFHEAYRALDTHRSTSIHLLRSSLLLSQALHRRIVARGMGLITNQAIRTLKNFRLAILKDGADLELFTHVEILAQLARWLSTALRDIIVEQQANLPKRKGNPYTPLPFIIAALYPAKDIFVVLGSTAAPVHGMTEANHFTAAFQQAAKLSGARVRHDRFQTAAIHVRKADLAPFIEKVHLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKY9</accession>
    <name>W3VKY9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKY9"/>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000599">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="9">
        <location>
            <begin position="352"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="745" mass="80384" checksum="1C84E73C1A1F43BC" modified="2014-03-19" version="1">MEVKRQDALPKCWSAGLGARPRSHAATQLLGRPPSAAFSLSSPLSPSPSPSPSPSPFVTLICYFGVSISAPRRIFFFVLPSHAIRQRRLLIWNSILGTGFLCIVAQRGVRHSLSTTTTAAMSEPSAVPVPAGEATTQWAYRAQKSIGLNTGSPSYSSVNGFDQVQGATRVFQYSPDGSTFAAAMDDFTRLVDTRNASTSSVKRDLPVPKVVDLQFSPKGGFLSTWERPSKLEDGSNARNLKIWDTESGEAVATFERKLQNDCFFQFSANEEYCVRQVSTELQIYEARHIADKGVVGRLRLEGITSFDLGPGDKPSIAVFCGEKKGAPASVRVYSLASLIPSPETPPAPVSQKTFFKADKIQIKWNKAGSALLFMTSTDHDKTGKSYYGETNLYLMSVRGDFDCRVGLDKEGPIHDFEWNPNSKEFIVIYGYMPAKAVLFSHRVNVIAELGTQPRNFVAFNPHGRLFCLAGFGNLSGTVDIWDRDNLGKGKIFSMDASNSSVCQWSPDGHFLLTATLSPRLRVENGVKIWHCTGDLIHVDMIDELYQAGWRPGSNAGLKPFPAQFPAAPSPSPAAAAYLATKAATKRPTGAYRPPGARGQNTPDIFKRIDEGGSGASTPENGTYQAPSMGNRKRAIPGAAGAPRNANAKDKDKKKGTKQQQAKNGAAAAAAAAVEVVPEPAVSGAAEVGGNTGAANLEKRVRNLNKKLKAIEELKLRQAGGEKLEAMQLAKIAAEDEVRKELATLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLC0</accession>
    <name>W3VLC0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLC0"/>
    <dbReference type="HOGENOM" id="CLU_537702_0_0_1"/>
    <dbReference type="OrthoDB" id="3248974at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68093" checksum="0E2BD9F9DE7B84FF" modified="2014-03-19" version="1">MTFPPAEKRGRAEAEGSAWIWRFCGRREDRTLTIRASGRQAPAVAISLSGIKLPLSAKAKGRIVKRFPLEATQTPPRSTSQFRPFCRASQVAKDGRTDKGARASEAFRKRLSQRCLISLHPFLSHTTIAVGQSPIMIDLRIDGISRPPLVDESPDTGVPDQGNVRDNWLARRKRYGNVFRMVEPTGGSGVYVGDALALKDVIEQPERFDIGPLHIFAAPMWGISETAGNWLSREGGGINIKHSSHLFSGSRLASLQQRFVDAVQRQFERIQPGATSDLFQQLRVCFFQSTVEALFTKSFPEGQYASFCIWDAELNAFSRGCPPPEALAARDSFFNIVLQQIDEHLSECSLQVRELMADLEQKHGLSHRDAVAICVRTAWLGSTQSPLSGAWIISLLLQQPDMINRLRTELDSFRKSAGAPKTVSEIAANPDLLKGDNLPLLDNIVNEVLRVYSAQNVPRFCLQDAVVRTLGPNNTIVPMQLKQGDVLQLLFWNVHDSQHNPQWWPEQKGKGIKYNGALEPFDETRFETDRRPAPFKIGGETVRTWTPFGFGMRVCPGRYWAVAEIKAFCLLFLDRFDVSSAGPMPRPDPQRWIGVLNVLDPLPATVSLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLF8</accession>
    <name>W3VLF8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLF8"/>
    <dbReference type="HOGENOM" id="CLU_1548273_0_0_1"/>
    <dbReference type="OrthoDB" id="10559651at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="173" mass="19125" checksum="9977AD237007EC68" modified="2014-03-19" version="1">MAVTTRSSARLSRTGGSREHGEALETCSTSTKRARRCSDQPRTKRRRSSSSILAKQAPFGDAERQTRVALTWQQRDLLQQERPARRPSQSKRSHHQSGSLGKALPLEEHADAPERSASRTYAPDSRLEPWTSNTPSDAYAEPSCFRAPLPHCLPHPTFSRPTASIRALATAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLI0</accession>
    <name>W3VLI0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLI0"/>
    <dbReference type="HOGENOM" id="CLU_005965_3_3_1"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000023">
        <property type="entry name" value="70 kDa heat shock cognate protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="396" mass="43723" checksum="0188BD20F594924B" modified="2014-03-19" version="1">MSSEVPATPVDETVYQGAIGIDLGTTYSCVGWWVNERVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQAAMNPRQTVFDAKRLIGRRYDDPDVKKDMQHWPFTVIDKDGSPFIEVNYLGETKQFSPQEISSMVLTKMKEIAEAKIGKESINPDEAVAYGAAVQAAVLTNQTSDKTADLLLLDVAPLSLGVAMQGDVFGVVVPRNTPIPCNKTRVFTTVEDNQTQVTFPVYEGERTQCKDNRLLGEFELTGIPPQPRGQAELLTTFEIDANGLLKVSAQEKITGRKANITITNSVGRLSSNEIEQMIKDAETFSKADKDFTAKHDAKNDLEAYVHSVEETISSPAANLKRPAKIQIEQELTKALELLEVQDASADEYRRASLRLKRSMQKAFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLQ9</accession>
    <name>W3VLQ9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLQ9"/>
    <dbReference type="HOGENOM" id="CLU_700565_0_0_1"/>
    <dbReference type="OrthoDB" id="3366429at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="349" mass="36902" checksum="8A4DEE3F05B9071C" modified="2014-03-19" version="1">MSQPNTAAIAVGAIFGGIALIFVSYKVYCKLWHCMHRAEQLPPISQPPTAYRGGVVVATLPTIAAPSYRRDGSSDHLASSISTSPQDGFVSTSTSEMPSPSIRPLDSVVLSTPGGYEPQFGGTSVMSSSSSTMTLKRSYLRSPSSHSFASSRRESYLPHSPRNRDSIQIVPPQPLGGMAEPRGLARDRSVDEFTSGLIWTETGDRRAVRANQRQQYLRSGPTRQSETASAVGSSQSSSGSAVMEAEELGAPEMQSLSAGNLARSAHLGSTAAIDPQLLRAEDSPLERLQSNAGQARPLPTRSSSQSNSNRSDSNASPILSPFGQDSPAASQPATEQAHSSSANQADEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM53</accession>
    <name>W3VM53_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM53"/>
    <dbReference type="HOGENOM" id="CLU_1402981_0_0_1"/>
    <dbReference type="OrthoDB" id="10590078at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="194" mass="20934" checksum="C44D58A401CA0C6D" modified="2014-03-19" version="1">MQCPGLRLCSTALKLLDFDEPEARTHGAGHVTSPSPALLAAMKLAMLPLASSHSHLAGPRQWCVAGSRPADPIRHTSPSIALPCPALPSLEMPAACCSSIALLAPSQARVHRCLVVPPASSRPTRYPTTTIPTRPSPRHPHTTLQRTFRKPSPSAIPIFSYTHRPQLHKLHIADDPFTVSPPAFILQPRIVEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM68</accession>
    <name>W3VM68_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM68"/>
    <dbReference type="HOGENOM" id="CLU_012494_6_1_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="90"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="329" mass="35725" checksum="F0B5832BBD6C47FB" modified="2014-03-19" version="1">MPSSHSFQLDPEFLQAAGPVLAAFSQLPKPAVHDVESRRQGFNAVLQQAGQMMPEHDVTVKTHKVKTRDGAEIDVIQVSPKQRKENGAAVLHIHGGGMISGSAQIYVDVGLVGVLSGESGVDFFSVDYRLAPEHNLDGIVNDSYDALQWLSTNAASLGVDNKRIGLFGDSAGGGIAAGVALQARDRQLSPPLRKQILIYPMLDDRNLVPDERIVPFALWTYESNVTGWSAVLGKGVAGTDKVAQLVRYAVPARVDDLSNLPDTYMDIGQLDIFLLEDLDFARRLHQAGVQVDLQVYKGLPHAWELVAPVDSTSTGKRIMAERIRAIQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMI5</accession>
    <name>W3VMI5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMI5"/>
    <dbReference type="HOGENOM" id="CLU_475762_0_0_1"/>
    <dbReference type="OrthoDB" id="163794at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF10">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="573" mass="62141" checksum="CFF7D334C6781708" modified="2014-03-19" version="1">MSNSATIDRNQEVTQRVSGQWRCQDERESPGLDLLPLRFVSTTMLPTGRSSMSERASRDTGRVGAKQHPTASAKHVWAASRPAVPHAPADGMSAPLVPDQGLARGSLAIQVNRWLAHHGISDPCLGVNFPIPRGRGRFVDVHVVASSMEVLAQAPLIFRGARLERHLVGLALYPSIMVVEVTGSSIADTGIAQQLADVLAPFAQVHDIWLEERSHGQDVSIRKSKMIALVETALSERGYRDWDKVTAIPGWAVLNGRECRLDYVGRLEWCTFCRSEAASFHTLETCLKVPDEMWQSLHHEAEYTNTAALGASPSSPTTTTPSTVHFPGAKHLQIMSAFPMLRTVPQACRTISMAEARVGLRTSMPQQVRTYYGKRIDPRMRLDKAARRGPRVAEASAPTSGSTVRMGLMLGGGSLIAAAGLSAFGSQRVQCESARPYASAPVSVETSGDTTTVSTQPESMVNVYQLSFGTICGVCAGVFIKKGLKLIAFLLGGCYVLLQYLNGQRLISVNWNAINSRYDKLVNSAAGPQAVNARGYSGSKLQRIWANFTNFLTADFQPRATFLAGLLLGLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMK5</accession>
    <name>W3VMK5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formyl transferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMK5"/>
    <dbReference type="HOGENOM" id="CLU_008537_0_0_1"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08650">
        <property type="entry name" value="FMT_core_HypX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047180">
        <property type="entry name" value="HoxX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43388:SF1">
        <property type="entry name" value="HYDROGENASE MATURATION FACTOR HOXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="2">
        <location>
            <begin position="255"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1123" mass="120240" checksum="CAE8839DA38C4EA7" modified="2014-03-19" version="1">MKILFICTAFNSLAQRTALVLRERGHVVTVEYALSPEGMIEAADLTQPHLIICPFLTKHVPPKVYNTWMTLIVHPGPPGDAGPSALDWCLIGDMGEMSNADQQLALIDAKHSAKNASASTRTHWGVTVLQAIEAFDAGPVWAFDQFELSAETAAMSKSDLYRGPVTRAAVHAVLAAVQRITECARVQAAQKGHESYLPVSTEVVAPARFRTQCVSNQVPFLGGRTHDRPLLRASQRDFFPLVSQANANAGRSRLSADAILQRIRSADSQPGMLSSLLGTPLFLYNAHVQRDPLPPAVASRQAALNQPGTVLATREGAVLVDVGADLPIWIGHLRRPKAKTDKYLQPKLPAVMALLSMPDVAAKLGLMDANKVPEWSATTGFGADASQPWKRREGTYQQVWVDVESSPKTASAVAYVHADFYNGAFSTTQCEILLAAIQWTLEVPGLKAIVMLGGPGYFSNGIALNVIEGSPDPSAEGWANINAIDDCVQALLAPRGIVTFAAMRGNAAAGGLAMATAADFVICAESAVLNPHYRGLGLFGSEWHTYSWYERCGSRVAAKFAREMLPMSSHEAKRIGLVDHVLDNDGMDAAQMLAAIKGLVNEVMDADIHAASAADGLVASGAPWTRSLRPASADAAQSALLSEQIVRNKMRYLAYLFAENADAANRSLSIDEHFQRYRKHELDQMTLDFFHPHRNPRFASRCTGFVRKLVPDATPMRFALHRRYADSANDWASSEQAATATVHLDEEERDEFDGLGDLPASAAVARLPDVRPEFVVHDKANDALGTRNARAYSVGHDTIASAVSADGNGMDGGSGRTSMSTVPTTPRGGSPKPVFSIGDEEAQRVEIEAEQLKVHRRSPDAGLLGTNAVKRGPTAISFAGADDVLAAAKARTGVKVGSERSTAVPAPRPAPASATKEDKKPSGKIQRFFQSLSRKSRANLQAEASTAVVPAVPAVTAVPAASAAVAAQASEATGKSAPASPVRTSSRMDAATRQRRRSSISDVFSILQNGSRPSSANQAGDEPASPTSKQERRRSWRPTSSSGINFGLDRSNEVNKSLPPTPMTKTNGFQPNMTATPKILEEPFKDGVAAQDANCLWSCYYSEDGEKVQRPLVANVQAAPISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VML6</accession>
    <name>W3VML6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VML6"/>
    <dbReference type="HOGENOM" id="CLU_411705_0_0_1"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316">
        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="595"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="634" mass="70731" checksum="89F5780F75A5A86F" modified="2014-03-19" version="1">MKPRGGSSMQGPPSARRRVGLSCSRAEDSQRSAAPNFLHTRFAGAAAAAALGSPLFPASFISLASDCARLEMNRTAAHGRSERQLKRRSLGGKRARSSISSASSAAVPSEPSPNGRTPTVPTIHPQQTSSKRTQKASSDGETAPVRSDSIGDEEGSDLDLAELRSDDAFLYERSAPVDVALGLDSSPPQPSLLERIEVHVAEHYLDCFGITHRDELVRHHNRLIPFFAKAPRFVSIHSLKQKELERDYTERKGISVEMSSPAASDCSLESGEWDGQEQCFYFDRHPTAYESFDPEQSFEGYMHVFSRPPTDDAAGSILGTHAPGNCDDTPAEEHRRHVRAERLCFNCGEPGHAVPQCPLPRDRERIRQSRLEFEQNKTLRSGDSEINAYARLHEQVASAQQRLQWLDEFVPGQPSTELIRALTWDAASATDDRDDREAELHAPTLDLPHLRNMLVWGYPPGWIAPYDPIKLVRHRIQHDTDWNDVEMLRGFDVTSLKADTTVAATADRSPEGASAEGTEHRWVDFHTQLFDSNRLQKFDTIHRRPLPRLERDGEPDPSLNRDRAEDKDDWERASKRIRLGRAERTMQDRKALWQSLLSGRFPSPPSLPPEEPPPPPPPTSPPPPPPPPPPPHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMT1</accession>
    <name>W3VMT1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydroxysteroid dehydrogenase-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMT1"/>
    <dbReference type="HOGENOM" id="CLU_010194_2_2_1"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000301">
        <property type="entry name" value="Hydroxysteroid dehydrogenase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006133">
        <property type="entry name" value="PRK08278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF3">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="319" mass="33959" checksum="64CA6EACE3DE88BB" modified="2014-03-19" version="1">MVGSLAGRTAFITGGSRGIGLEIGKCLASRGANVVIAAKTATPHPKLPGTIYTACDEIAAEADKAGSGAQAHPVQLDIRDASAVESAINAVADKFGGLDMVINNASAINMTPTKDAAVKSYDLMNGINARGSWLVSRFALPHLLESAERGNNPHILTLSPPLNFNTLSTTVGKQDPPAIFPYQFAQTASAYTIAKFGMSLLTLALAAETTGKVAVNSLWPYTLIATSAMKIVSKDASVQERKWRNPAIVAQAAARIVEENAANFTAKFLVDELYLREKGFTNNDLHKFNVDESTHLNDLAEDLYISQELRDAINAGRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMZ3</accession>
    <name>W3VMZ3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lateendosome to vacuole transport-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000917_3_1_1"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="4">
        <location>
            <begin position="1646"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1870"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1951"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1961"/>
            <end position="1972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2015" mass="221118" checksum="BABA7B2035C0E754" modified="2014-03-19" version="1">MQRNGSADSNPWDAEPSYAQRMSTYHADQHRSYDQQMQDVLDSPPAQQPNGLHHDASLSTSKPAAHDDLDDDDDDDDDQDFVYAGIDTAAAIRTATPGDSNASIDLGSDSYSARMKDILGSDDEQQLDMADADDQHAGSSDHAPASSPRTQRALPLPADGDQSADAPPSDSGSSFRYPHPLPNDVSFDTRSASSLQNRRPLSSLPSSSRIFTPRSTSANGLSLLRQSHTMTSASTPQRPSAYPSLSRLRATVGRSTAAALAVPAFAQLHSHTSPLGAPGSPSSSSSRRKPRSPLPPDFFASAPISSQNDDASRSALAHSSTPQRSRQSSFSTSVGSSVRGTTKRRRARASFPYGGTLTSTTLPPAQSEISLLSDRSFPSSAQRGAKAVHDHQDAPSEHADKRPELKDTMLNERDELARDFVQWSVLRRILAAAKSAPDAPDPIPTVLAVAGGLIAVGTQGGKTVVCDLAQEPVASCGHDGRGHGDAVTALALSSDHSFLGVGHASGNIFLYDLSHPARAARHVPPVPLSSVKAGKREGHLSGSAIVHIGFVGLRHTAIVSADNKGLAFYHALGKILGVSSNDTLRLLGKYPQYEHEDELGLADAKRRSAIFQLTPLPLGPRPHAADETTFIAMITPAKMVLVGLKPAPRTWYRKMNTTKHTEKGGEGVVADEAAQPQPPGCLAWYPASTETDGKRRRQTNPVLAFSFGRNLHLVRLVVRRIERRPDARTARNGTLPPAEVVEEIEPVELTGEQGIEEPDGIVALQWFSPDLLMLTTRTGLALFDCRAGKVTERMRNGSAAVVLARTVEQKSLDAVLLGKPYDPHAEIPERDEQGQTEERQRSWAVNHSIRVSKGRSFFLTTSDLVVGTLMSWADRLLLYVSRGDFLSAIELATLFHQGRFLGSAVGLPSDPSERTRIVADKLHELMAASAQYAFSPDRLTDDTHVTPDGRGVDRTELFQGLARVCARACLSLGKLDFLFETLYDKYEDNGIEAIFVGQMEHFIVSGELSSLPIPVVQRLVAFRRDREEYDQAERIIWHVDPKSLDLDQALSLCLDRRLYDALIYVFNAALEDYVSPVIELLHPVRRAVGRRWKEQHLVSADEASADTDPYAHVRVKDHDADAASASPAVADWEAEERDLEDGYRVFSYLSVVLTGNRYPSQEPFEHAEQADKAKSSIYNFVFSGSCMLWPPGPGGRLVLYGLQDRPDEPEHVGNSAEHEPIYPYLRLLFEFDAEALLDALDLAFEDGFLDDEDVVGKRISRQLAVDVLLELARSQGAADRRAPALPLTARVFVHIFVARNAPKYPQFIHLPQHHVDQLLRSLAIPLHDGDGDEEEVETVESTRADRELAAECLLSHYKPRFDDAWLDTFERAGFGRILRSAFRQEDKWDRLLGMYLRDHLQGGAAASQLDADAVDEGPGDAFAHFEETLFNASRRDTARRDELVTRLHEQLVDHIAELLDLDALKTAAMLDRFHPDRHAQVLQRLAQLDDKRHLLYLQCFFEPMHVRRAVSQPRSDESGSDGLDWVHHKPADGADAGAYSADVGRADPDHLEARERQVYLDLLRRYEPAAVVRNLDAREAGYFDLEQLVRACREADVAVDSRVAANSDALLWALDRLGRPGEAFEELDAACVRTAQSLVLVAEECTADVLLADVRRCIEVAVRLCIERANAFGGHESDDEAPPPTALDTDEVWFRLLRSMVRLVHDVAHGSWRRAAPGSEGGEKDLLSGVRDIVQDTLSDLISSTAAEAVSFPALFRRLTSGAEEGKEGGAEYYAEIRGVLDGMLSAYHLRAELLGITNKLFERDTFRQFRKLHAQRRHGWRPSVGVGARCASCGLVVLGPKRASTAAAEVDVGREVEVGSAMLTPQVLQHRRAKSPYDGKAAPLASPRLDKGKGVVRSASSEIRAGADDVDGYFAPSREMSRSSSWANGGASALMTRTNSTASIAIRINDEPPQTQEAEPQGEAEEEEEGDATLTAAQFMPAWQEEEVERTQRIVVQKCGRVFHESCWHDRRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN54</accession>
    <name>W3VN54_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN54"/>
    <dbReference type="HOGENOM" id="CLU_009043_0_0_1"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="500"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="967" mass="105914" checksum="9025301E542C07DA" modified="2014-03-19" version="1">MEDLLKALRNIGLALPDPEQLLQLSDPDTQVQDNLARHLSLTPANNDLVPDEAEQSANSTDDADSDADEDIGIDPLVDADLFKGAVQALLENYNKAIDKERDALRKETEALAAPKKLKAVPLKALLARQAAEVKKRQDEVYVAAHDPESGRKRRRVYLPRQTFDGAGSYASDKPLAELARLDADELEAPKRFTGRYILCKVASSLNLYVGCTFIGLLPSGNALPITIAHFTSDLHLSGEQLDALLPVGTVLAVREPFVSLNHFAKGGPCQAGKSVPGVRVDTPTDVHVLDRLSNADAKILDAVQWKVDVAQDKDEHFSDLGSLLRDSPAACNSKGCRWLQDGPLSRAVASTSLDRVADQVQGLDTEQRNKLSARTRQLIQSLLSDDRPGAAYRELCAARLVRLPTSTSASAIAENLELEAEVLHRLCNYETSRLAYEAALQAYAPAQRAAAQDRILEKLTAVRAAQKASALGPSHENVWGYYFDSQSYATPRFDMQDWLGPVAIQDIPGAGRGLVLTRDVEEGELLLCCKAAAASYAADRGCRGVNLLRYSVESGVTSTTTQVLAATKSIHAIIDRPQRWTLPIMGLTAGPDVEYSRWVAQPYPAPEKRSYADAASEPDHLATLIAACTVDASAKRTEEQRWKETVLEGAARPAIDSSYVDGVLRFNAFGPAANPGGKSASSDADDAAHDSELSRSTMVHPLPAILNHACLPNVSSVFFGDIVTTRALHPLKRGTEIMHQYVKGEQPWLIRRSQLSKHGFKCSCGICVLDERDGEERVRERGQIVGGSLSMLQERSRIVLKSSTQPDASRDKEVEDHRDLAESLQELVEKVQATYDASRPILRPDLMKILQLQALHQSHYDMDAAIATELQALESVGCTVAKDNAHGRVLDQLPSLHFDGGITSMLTLAKFMLADPSRTDSKKEARRWVEQAFYTHQCTIGGGLDIFLDRWLDAFPDLPFRDWLPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNE7</accession>
    <name>W3VNE7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-phytase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNE7"/>
    <dbReference type="HOGENOM" id="CLU_020880_2_2_1"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="72597" checksum="1C96B77773E1CB85" modified="2014-03-19" version="1">MPTPARKERRSSDDDLEAESLILHRLSTDASGSSRIQTAGGTTAAPRVTDAYDDLDDEYEVKRKELDSLPARGVLEGSNNSTRIDKTGRPAWFRGMLDGDVPLPGLNGRGAGMSASMAQRSRKKRARCMRLAMLGAGGLLVLGAFAFALGPKLGVSPSRIYDYMGDKWYGDSGVIPFEFNKPVGYPGFYTTGVPPNFAEHMTRTAPAPRQTIGSAPMQTFVPGFQDADFKPFEHMGPLTPYVSSSGWGVDDVKYAGTPTAAGKTCELVQAHMLHRHGARYPTAGGPPDVLRDFLRENPQLRFSGSLAFLNSYKFGVGEELLTPVGRGQLYDSGVKAALLYGKLAADDFAEKDARGKPKTLFARAGSQQRIVDSGLAWLNGFFGANWTASTSFEIQIEEPGYNTTTAPEFACPAWNHAGSAPGGEMMSRWAASYLQDAMLRLGHDFGGATLNSTLLMGMQQMCSYDTVAFGTSDFCALFTRQEWLDYEYAWDLKFMNTNGASSPLGKAYGLGWVNELITRLEAKPWNASLQTSENSTLNADPTTFPVDRRFYVDFTHDSTITSVLAALALPHFDEVLKVPDGGKKLDANRNFKTSKVVPFAARLVLEVWQCADETSVRMKLNDAVVPLSQYTQCAQRPDGMCAKKDFLTALAQRNLQSEWQKCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNI5</accession>
    <name>W3VNI5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4042 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNI5"/>
    <dbReference type="HOGENOM" id="CLU_319376_0_0_1"/>
    <dbReference type="OrthoDB" id="2553858at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025283">
        <property type="entry name" value="DUF4042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052107">
        <property type="entry name" value="HEAT6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13366">
        <property type="entry name" value="MALARIA ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13251">
        <property type="entry name" value="DUF4042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4042" evidence="2">
        <location>
            <begin position="344"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="917" mass="96631" checksum="B5CCB839F7443D0F" modified="2014-03-19" version="1">MEATHASQGAEALLDKLRESRLSSDERRTSLEALRLALDPIVAPIISTTFDNDGASISLLVRAIQDGPNDVRRVALQTISSGVDKVETPHISQATSDELMAAIEALLKSTLKIQSGRSMGTLRSRPRIDVSTISTSSLRAAAAALKAIHSLLRIAPTDKSAARASDTNSLLSGLGGLLDVVVPCLYAGLSQAGPSNEPGLRASSGLRSGALSWMEPSRQPLSRARGGHTSAAETDGETDRFNASSSGEADRRSDKSESERSDFSVASSRSASRSRKDESRQHDATCRLIRQNALHCLVELNRRHANAIVARWTDLLPDQLAQPVAASRAVSGGVVSRRSGVGSSMAFSLCSLILEDPSTSVRLAAVSALESVLTHGTRQLSMAQERAQRALTFTSLSSQLAGWIVNVRSYVVLALQRAAIAPRTPARVEGQADGAGSLYPTALLTALLRLARTFVTSTARARLVVKNAAVLAEPAAAFVAHSDPDVQTAAKRLVASLAATQDAAPGASAIRRPSGVAASADEIAEDSAKSSSLDMTMLLGQSEALTTALAERALDALDQTAEPNLAMWTALVKRLAETASPVLTGATCSRLVVVWQRISSTSRSGDQQCSLLASAADLLRTLSRHTALDVDTADGILSYVHTCSRDPDEAVRAAAVRMLGVVILPPDASNAGDVDMAQVAQVLHNVLWGEGGSERGLLYDTSGLVRQRASWALANSVEARLRGGTGVADSQWADLARYCVAAGRDMEGVAVSACRASGSLLAMLPATAGENDRIAGELVDQLCRVLGAGGKPPKSRWNAASALSRALSSDATVLRVLASGEKLDRVTELLCLSLDTKVFKIRVSAAHALLSLVGADESRRLEVLGTQRCARIQGIARARLTQLTDSPASQTKEAGLYSDELQRLLERLVARLSANTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNR0</accession>
    <name>W3VNR0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNR0"/>
    <dbReference type="HOGENOM" id="CLU_027522_0_0_1"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833404" evidence="2">
        <location>
            <begin position="20"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="461" mass="50512" checksum="6DFB3E842813C5A9" modified="2014-03-19" version="1">MLIAVIFTLLFSAVWVVSGQAGPGAPVDRSQSQSQGQGEVQAGESVFGSGCRWDPTQSNIEEVTFTFRTGEAPPSTWFADVHNANQDAEAQASRLRRRADPPPPPPQPQPAQGDIKDEGKVVSLEELSHEPVLDASYHTRLIDVLTYRARYGTFGSSLNSAGCALPAFSERLAHLERQEREIVNNYTRMHKHTAGPDNRPNAMFFWAGLSNYDPNVRADLIQTVVFYGDGCAANPRVGLCVYAAEYSNFRYNAEDHMCMGSDMPVFYPVDSPMTVVYRTQMGFRTQESWIDDKMVSYLRSAGDQVMNSFVITQECKNCTWPVSPQIYSNIVLKFTTPEPHFDQLGLCTGGAKLKAPPRTLDGGKTWVIDEVWVPAGKHLTVKGEANQNIDAGNKGDKKQRQAGQKGQPEKQGQRGQQGQPGQQDQPGQHGQQGQSGKAKQGQPGQQGKKPGQGGNKASGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNV5</accession>
    <name>W3VNV5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-dependent formaldehyde-activating gfa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNV5"/>
    <dbReference type="HOGENOM" id="CLU_055491_3_3_1"/>
    <dbReference type="OrthoDB" id="428768at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="147" mass="15590" checksum="653E1E94F9A5173E" modified="2014-03-19" version="1">MPLKGSCLCGKVQVSVKDDALPLKPVVCRCTNCQQTAGSPYSLVTIVPEDKVEITGETKASCLYGVDTDTTTTSGNNSKRHFCPECGSPVQTVSPTRAGLAIIKLGLFAKSDGWKDSIGTPVAQIFTRNQKPWESLIDGVPAVEGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPZ0</accession>
    <name>W3VPZ0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ceramidase</fullName>
            <ecNumber evidence="2">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPZ0"/>
    <dbReference type="HOGENOM" id="CLU_011300_0_0_1"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="251"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="303"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="834"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1016" mass="111961" checksum="D36E100CDE0CDC77" modified="2014-03-19" version="1">MHVSSRAGHQLMHCGAACTPESHADRDTNAGHSYTANQHVSLTAGVLRSQASSKRRHNTSAGRTIPAILAHAIYIRPRKSASISWPALLQHHSPPNLWLPIHLLPHLCPRRLKDQYQIEPTARERIFEPSHILELSRQLWPPSSMAAAGYQLVPSRDSEETCVSEGDTKDAFKEQHLSTPASIEGTGVKSATRRNRRFLLLKAVVSVLLLGSAALAACCAYRSPSFQAVWTDRPITPYVASSAAADQSLVFGVGIGDVTGPVVEVNMMGYASLPQTNTGLHIRLRSRAFIVGSAQAESPSFRARLASRFKSFIPTADGAADRWIFINSDICMGDSALRKTVVDRLRQEHPGLYGERNVAFVGTHSHAGPGGFMQALLPTLTSKGVILQNFDAIVEGTVRAALRAHDDYQARSDRIAQGAGVRLSYGKTRLEDAHIQRSRYAYEQNPQHERDLYNDEDQDHDFSLLKFEDLAPQHEQPASAAGFLSWYAVHGTSLYENNTLTSGDNKGLAALLYESAQQPDQLPGQNSFVAGFSQALVGDTSPNTKGAWCDDGSKCDHKHSTCSNSKGQDRVQTCHGRGPAWGHDEYIDVSPTGSYDFASNEMIARKQVDAARNIMQRDPESTARTQDEYDRMTMLTGPVKSVKMNVDMSQYTVYRPDRSRVKTCPAALGYGFAGGTTDGPGAFDFVQGSNKTDHHNPFWDLVKGFIKNPGPEQIECQAPKAVLLDIGEIHKPYDWGPSVVEVQMLRVGQLFILIVPGEFTTMAGRRLKRAVSDAIVRAGLLPEGVQPIVQVSGPASTYGHYVTTEEEYSVQRYEGASTLFGPHTLEAYMDVFSRRLVPALREGARDLPVGPQRAFDIQKAWKLKTGVVYDNPPIGHAFGDVLEQPLLSYPIPNRANATLFGDSPVDVQAAPSNISVTFVASNPRNNLRLEATYFEVQRYSDRGEWITERTDGHHSTTMRWTRTNELHGSSKIQISWAVEGWTQPGLYRVVYYGDRKAPFTGKISPFEATSAEFYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ02</accession>
    <name>W3VQ02_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_02038</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ02"/>
    <dbReference type="HOGENOM" id="CLU_089996_0_1_1"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS63728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="176" mass="19468" checksum="881CFE5C03339B87" modified="2014-03-19" version="1">MFAEELASLRRQGVRSVLFQVLNFISVVSTALAMWKGLSVLTDTESPVVVVLSGSMEPAFYRGDLLFLSMPSGPLKVGDIPVYKVPGADIPIVHRIIETHDAPDGDQLILTKGDNNESDDIALYNGARWMRRSNMVGKVRGYMPYVGYVTIALNDYPKLKYALLGIMALSLLFQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ35</accession>
    <name>W3VQ35_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">triacylglycerol lipase</fullName>
            <ecNumber evidence="3">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ35"/>
    <dbReference type="HOGENOM" id="CLU_029538_5_0_1"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="461" mass="50141" checksum="1DA6DB75EC1377C4" modified="2014-03-19" version="1">MGQNNDAQGCLAGFRGLFAKKGGIPLPANDDFYTARDSHFSARADGAVLRSREIEVTYFPGFESPALQAWQVAYKTKAQDGMTPQVTVLTVMRPSTAQPDADGKYRIVFYGSKCDSAGTNFRMSYLLRAGNDYTLGAASEQVFIAPYLDRGWITVVPDYESETCAFGAGSQSGYAMLDSIRAALSFEPIGLHKDSNGAYLAKVCLWGYSGGAFAVGWAAQLQPSYAAELTQYLVGASMGGLPSDFKACGQRTNKDVAAGLLVGIMQGLANAYPELQDWLNLHANKTGKAALQKALTKSFGTVMSSCAFQDVLGTYFDVPDLLADPLIARIMQENKLGMAEEVPQIACQVYQSLHDEVVPCQTTDDLVVAWSAKGACIDYTKDTLSAHVVLCFTGCAMAIRWMQDRFDSKPTRAQPGQPHVETVLTSLDTSDASLTLGRQRQTDMQNLLENQYKRPGRNWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQE4</accession>
    <name>W3VQE4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQE4"/>
    <dbReference type="HOGENOM" id="CLU_446978_0_0_1"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16039">
        <property type="entry name" value="PHD_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="193"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="611" mass="65130" checksum="294CF0ADECF90103" modified="2014-03-19" version="1">MQRSDEIDKAVSTGAASDDVETMDVDLTPPKKRVKSAQISRQVSVEGDMTRDTAADAHHITKQRVSPTSGLAAAGSSATTEPEIKIEPVAGAPLSASLPAHDTTPVAVKAESDLLGVTAEPPIEADDVPAPKKKKTTSVSSKSKKGSSTKKASASTSAHAESSTSSRTKVKVEEKAPPAAAPGEEEEEEEDDALYCICKRRQDDIEGGMIACDRCDQWYHYRCMEITEDDAELVDRFVCPPCHEFTPERTTYKAACARAGCRHAAQTPFSKYCSDRCGVLALSARLAGLKVNRNKQAAAMFEADPRVVAARKTEALTQRTDAFYDAKGEWDRVVAAGLSEGATDAAVQRLGLSGAFALMRSADSAQPFPIANGTDPAAANDESAEQAPANAEGPTSDASSATSLIGLAEHTLLHLVSDRVPTLVAAPSTSAPEATDAAEDEEMPDEARSKTKKKKTTKGRSKDADAGSGPLCGYDQRLHWDDPDFDAWAHTDPGRSMLAHEAPLDGELDDPAGPNAVVCATVKRKCRRHIDWSNLCELALDAEKAALAAQSRILTHSKLELAAAKDRLHAEYEAVQQLAQQQRDGQKKAAEQRDRDMALAVAAHGTRRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQN9</accession>
    <name>W3VQN9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup160</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002799_0_0_1"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="132"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1686"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1696"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1713"/>
            <end position="1728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1728" mass="186984" checksum="7634FEC261442BA9" modified="2014-03-19" version="1">MIAVAEQKIREARLRFPSGVRGTRTAEGGGYDRSSDLLDRSITTCLAARRAASYPAIMPLPYTPYKLASASLIAPAPLLGAHSHDDDTVTVPTPQHPAVSDEPEPVSIAAHHAVDARLYFPSSSSSRFDGGYVLARVVAGGKELELRWSNLQDQPSTPAASSKDHSFSNSLHPKLASEPARTFLFPAPLLPGLGIFADPASNRLHVIAVTTTGFLYRLVFAAPYLFHDSRLASDWSSEYRIQSIASSESVLAASLRGTANAAQLYPVDSGLALVTCADGTIVKLSRSLSTGKDANDGAWKETVLRPTSFLSGVSRFFGRSNAASDSESSPSYALSLDVYPGEVGSALAFAASRDRKLRVWNLVTDSCIRTIDLPLQMDSLLSSDRQLVVAEDDHGGASDPSDTKAFFSTVSRPYIKVFTPGADEGDGYALYVLAYIPASPPSGNFFALYGVQLEDAKGSSGGLGEMTLLWQKQCDADTCGRNVELRDVAFTPQGGRDDGWVLWALWDAGAGPVLKYAKVGIESANPDESSMTVRSTAEDLSKDDWRTVASERIYRPLHGEDFEATLDATKEIVDAAEIFLDRVLEPGRFSEATLRLALSTYKQVVAESSRQPSTLFASLRDEVAAVVASGCQLENDPRTGGPMYEKLYAARVREWMRFVGLAEQIETSARWPIGLSLPAPALDAVAACGDVVVPLIVSRDTIALPVNEDEASIIERLQRRLFAASGKSRLGGAPSVDSAKEERALLIHAADTHPTTILPTLGRTSATVAEVLTLLESAADLCACFTAPELEAFAAGLQNLLSNPLTISVKEAVAEIWTNNFAALGGEDASEIVARVASELGASLDSTLTDMSVLLSEVASESERASSASPVASTDLGSAWTADALAQTLASRHRLAVSFLLLLTALAAQDRMADMVENESTQIAAALSIFQTLGAALQLARTDGAVQVAGDATDAAEADSIVAKLNQMSVAGRKSREPHHFAAPTLLHQCVRDELLRLSSSASRDSGLALPLKTAVLGGLWSLGLSDLRDSLAAGGKPMLPYANDRHNSIAFAILVQGYPSAAEILLSSFPETAAGEYVRARALVQMQRLDEASTCFEKVVSALEMQMHQRGRTSGGLLELLPSSIASAEGEERVAAYYRHAALFFEPLEALEHVIRFCQASIDAVGTYADKRIVKTGSPAADAEANRLAGPKEVWFKIFRCQLALDDFEAAYATIMATPYEGVRKDCLRNLVSVMCEEGHIQPLLHFTFPGLQTEVERTLSFKARNSDPLSVPNYYSVLYSYHVFRGDLKSAGAVMYQHAERMGELHRAASAGLDGTDPLERFTVVAVEQAQSYLAAINALTMLRHENAWFAHAADPEESAAGSDSLFDAAASVRTGAGSKQTSSLTRYIPAAAYSQRVREIRVVSVEDVRREYTLALARLELVKRYPDLAYSTTVLRPSDAVLLFVNSDSFDSAFGMAWCLGVDMTPIFAALTIKAVALTRAKVERDRLKRPAESTRVNGDKAAVDNEDVHPEIAELEEADADLLEPEAVFLTLSEKSASWEGAAAERAWRYVRHHLEMYDSEEDGRYYRVVLARVSALDHTSLPSWLTEWFSRTGNSDVLLRVWIDNGLIVEAARFATKWLQDATSQASSLTRAYEQCISNHILERLLINLDDKSGVILSPRKKEAAEARSALEQARKKHVDALATRSKTLKRQAEQDALRQEKRREQQGDSASLGRSTTGLRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQU4</accession>
    <name>W3VQU4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQU4"/>
    <dbReference type="HOGENOM" id="CLU_021989_0_0_1"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="460"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="756" mass="80722" checksum="7FCE8A14A14FEC71" modified="2014-03-19" version="1">MRAPSTRAMIVKLPASSRASTTLTRAVQQRAHSNSSKARFSNDSVSARASLSHNAGGRGSRYATAAAAVTAAALTTWYSVSSPVHSEAAPSVAPLGGASPPLVSQQDQMRDRARLQGVYAWGSNRYNVVAPDAPSVTLIRSPRSIPFFDGVALRDINLQEKHGVAVDANGDVYQWGLGFFDPSVREVTAVEDVPLGRRREKAAANLKAPLANTASLVLNPVKTLTGKNIIKVEATEEKIYALSKDGHIYVFSAVQQQQAKPKYPGWSKNPFTLFNAFASSTIDHEVLHPAPSAHWGSTEKVYDIVAGADHLLSVTNKGRTFVTPIGEEANAFGQLGTRRVWLNSPKTPDSKAGHVETLLEPRVFAELEANHGGRPIASLVPSDWLPAPPTQTNRTSKPQASSEPAFETSTDPAPPPKPLAEPVNSIRWCTTLHEVPALRKVNVVQIAAGNEHSLARTHDGRVLAWGRHTHGQCGLGTSFSMECVPVPTEVVLSRSFSNSSLDVRATSIAAGADNSFFMTTRREAGGKFKIDLLASGKGQWGTIGNAMWSQVVSQPSRVKTVSGLIEFSEATGQTHPVPIHSISVGKPGHVALVLDTVEPDGHMAFGRDVMVWGANAGFQLGVGKRSNLAVPQHLKPLPGLTTVAGGNIISEQDGLAVSPEKIAALAAPKPTPAFDPKLREADLNSGALTHMPHNRLQLASKTKTDTHLPPAISHKDQLNPTATTAVQQGKTKKNVQIEESIKAGTVSTVVFWKIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQW5</accession>
    <name>W3VQW5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative 5'-nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQW5"/>
    <dbReference type="HOGENOM" id="CLU_019028_1_0_1"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000043">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834800" description="Putative 5'-nucleotidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="39"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="2">
        <location>
            <begin position="445"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="780" mass="86886" checksum="31B231A284504758" modified="2014-03-19" version="1">MVTATVAPPPPSRTSTRSYPSLLCAVLVALAVISAAVASPPVEPLSSKLIFNHHVDSDAESLANYRAEVEGFQRWSRERGRMPRSDDKLRELELGDLNLLITTDIHGHMAGHPKLSPPEPNYSGDWGHWASFASKMRTKAHSEGRDLLLLDVGDLHDGTGLADGFPPYNKDEPGGKEAVDGHVSNQIFSMVDYDLLTIGNHELYNFSVAQDVYQNFVPQWGGRYMTSNVKIALPGPDVANATYAPIGSLFNTLVTPVQGFKIMSYGILFDFKLAAKGIQVQPPQEMVEEDWFNHSLDRAEKWGVDAFVVLGHMPVSGDAGWDAVHAKIRSRFPDTPISILGGHTHVRDCRMLDSQTMALESGRYMETVGFMGIRDLQKRKRAGNKGKVKFSRRYIDSNPRNFVHHLGLNSPRELATKKGSFIRFIMDAISEAWGLSRLHGVVPQDYYLDRVPYGDSSSLLSLLADEVLPKVVRPSEKARRDRKSLVLINSGSQRFDVFSGPFTRNDQYIVSPFKDQFLYMADVPWGIAKHLLHGLLTFKQGAVVEVMQGGTQYSDGDALLRYGSGFVEDIFVRWQKSQWFKFLQAEQVDGQHADEQGNVTAKSVEQLEAEEDEALLKFFHKYDSLDKPSLGYRTVDQCAGAGDDTVHSPLPFFPDQPEYVASNPEPMPASDDEVVDVVFVDFMRKLIVQLLNRYDVQRNGTGAYRVEQLKRWGDITTQLLYPRYAEMEWQPAEGAHKAVAAQERRARKMGYAPLELMPDVGAASAHEATDTAASSSNSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR33</accession>
    <name>W3VR33_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR33"/>
    <dbReference type="HOGENOM" id="CLU_010811_3_1_1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="216"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="634" mass="69148" checksum="B4654BAB4901F48F" modified="2014-03-19" version="1">MSNRPGNYRSVPAQQQARDMPPYKQVSYTPPSQQQHQRPGPRAIPSDQSHNMSGSFSSGESSGATQRLLPTQAYQPRNNAAPQRGAYPNNTRAKTAATASATSTAGYKYATGAQGQPIYEGPEDDDDLHDWKKESHSHAMSWRGIANVLTLAFLVVGLVALFAGYPIISHFEKLYNASKKGGYNLGGTNGSGQVPDLPLFSLIDADTPASALKRVSAADGKSYHLVFSDEFEQEGRTFWPGDDPFWEAVDLYYGATGDYEYYSPEAVNTTGGALTITMTQKTTHNLNFQSGMVQSWNKFCFQGGYIEFSMRMPGGPSTSGYWPGLWLMGNLARPGYAGSTDGMWPYSYASCDAGILRNQTWVNGTGPDGAINSQGTYSVGGRVSFLSGMRSPACTCPGEDHPGPNVNVARSSPELDILEAQIQNRAGVSHGYASQSYQIAPFDLSYEWVNTSAAVKIYDDDVTEVNSYKGNVYQEAVSALTQIPDAGYVDTSNQYLTYGVEYQPDWNENGGGSITWYINGKPSWTVNGKAMMANPPMDIGIRTVSVEPMSIIMNLGMSPTFQRVNFGAGGVEFPATMAVDYVRVYQLDGQNDRITCDPADHPTAQYINDHLDLYTNPNYTVYPHAWPKNKLTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRE8</accession>
    <name>W3VRE8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRE8"/>
    <dbReference type="HOGENOM" id="CLU_1555959_0_0_1"/>
    <dbReference type="OrthoDB" id="2553467at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="176" mass="17918" checksum="3F10EBC625797267" modified="2014-03-19" version="1">MSGAGASVCNGTALPTSTAFQIAAGRPFCGYVGFSPSTSGSSAIQSCCAGMVLNGSQYDASEAAASAPRKYEGCIVYCQVAEKFARRPTEWQRCVEPLLPPSSVGDQWTCDFGRNISISGATVNGSESNSGSNTGSPNGAGRDIKMTASNTLLPLVILILLALQLVLPAAAANTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRL2</accession>
    <name>W3VRL2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRL2"/>
    <dbReference type="HOGENOM" id="CLU_007975_0_0_1"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="697"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="938" mass="100837" checksum="0FB3550395D67C39" modified="2014-03-19" version="1">MSSTSPQKRRSNAFRTSLIEQPMRQTRSMARISDVLDATQHFSMSKAEAQRPSDASMQSRAASPRKARASQAAQLDHFDPESPDVSLAACMESPKKGRFDDFEFELENSKHELPVRRTRANAQRQPASSSSAEAGLPRSKTSTTLNRTMPANPLLASRKENSTVTVRDPVQPGASPVKPAATANRPSRLRGHAAAAQSSNLDGTGTADVATTSAAAKEQSDTKIDSMPHPDDRESNQRLLFGTSRASSRDPAQPNPFSTSSDTNSLAQLGEPRHSPVKRFQTKSEFVIQSPDRPDRRPINLLELKPSPGKAQRGIFRHNSVVDEDDDDWGNSDTSELNITMDEIKLVKGPSVPKQAATRSHEVSSSSCAKGDASATSNPRDTTHKMASTTTLDVKDIMSPETSDMLANLEASLVKLRAKTHSQPAAVDAKKKEEQNVLAPVKRELGGLRASGVSASRTQTFRIKNSTTSADLANQARSATDQSGDSSVFKRPSGRVSALAKSRVSSSEHGSDSSLTSSRSMMSFGAPRLPGFSEVGGRASRPMPPSARTSSLDTTSDDPRHEELAAAEEEQARITEAKRQAELKAAKRKSMSSILSSGMPPTLQRREASASSSGSQPPQESSAKPTSPTAAKPSEDAAEAKKAAKAARRRSLFTYVPTKREDADGDRSIGNLSTGLAISTTASGNASEADTSTQAPRKARFLRGLTVLVDVRDQDGEDASGRWVEMLKNAGAKVMLRFPERKLTHIVYKSGRPSTLHSYRALDDPKPHVVGISWVVACLEQGKKADERPYLVEVAKEAIFANPRRSSMAPKHVPSSATSIRELPKEMQKSVELARRKLLAHAPAVSSPLRRRISSRSVLARQLAATTIHSDTADTGGGAARPRASSSRSTNEPAENADAAGQGLRSSSDDDADGDLHELAQYRETVKQILSKPASAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRP4</accession>
    <name>W3VRP4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRP4"/>
    <dbReference type="HOGENOM" id="CLU_1422268_0_0_1"/>
    <dbReference type="OrthoDB" id="2555756at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="179" mass="18254" checksum="43AF1803D60699C1" modified="2014-03-19" version="1">MYSTSPSSSSMASSSGRSSPEQSAPQPASQPQRSNSFLLPQFFFGSSANQTSSSNTDTTPHPATNALLSQPPRRTSFGAGFSNGGRLSALSAFGFMSSPSSAFPSSALSSSPPPSLAGAAALSRQSGSAIESPTSELAPSAPPANKPAPAKRHHCFPDGMGGTMCVEVKDRNRRGSSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS59</accession>
    <name>W3VS59_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS59"/>
    <dbReference type="HOGENOM" id="CLU_398472_0_0_1"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="798" mass="88281" checksum="E745942C55CD1A9F" modified="2014-03-19" version="1">MEESTAVLQLAGEQTRGSRPCSWECRLPVKLSVPRSPHSGEGLDASMSVAPPCFRGANICQPASEGRYEGDLSRSAFSCGARTEVRRLSHCIYPQLHHLHDRPSTIRMSHLSAQPSTSTDGRRGGLRVGDAIRLAAKSMSSLRSSARSVSGASAANVDAVSSAATSILPSPSDEADEAHKMAASPPESDSEYRWHLLRHDNGHVWWRNVDNMANFILHWQNRFHQHGDMFGTCLVRRGTGPCKLGLGELREAVRRLRFQHPTIALRLARRAEFGIAKLELPAFIEKHVDLQVALVYDGVQSDEDVERWLDQVVVVHNEERQEDGAEYAAFIAEATKDGVPGRDRLRIHFWPCDEGAGIDARLLVEQCHSVSEGIGTLLVFNHLLASVAGVLADPSPQTLRWGEEVARLEPALQDAIEHPPPSWDVSRTELKQVERVNQERMNGKATPPTAVDKIAGKFVGLTLRSHQSRSSLRTMAVAPPLVKVCRAVAEKGDMLPLGLLPQTGKPFEGQRTHTAILTDTLDGDQTRQLLSVLKARGLTLAPFLEACGHMATTWTRKHRGLVAKPKSNRGYDEPDRILGSFSNAISKRDTLKPEYRSYLGLCMSGFPTKVAVAHATWTPQAELSTTPSGTDPRDPLPNITRADLAQLLSLTHELAGQYTEGRNNANWLRYDKALMLSTMHTEYLLLRSDAHYPSMPWLSSVGRVDPFFLPAHPITPSDSLEVHSLRIVGRVAIRQPILHVFSFRSQTTLQLSYAEWLYPTPDPGQPQSILQFWLQTFRATILALLHNPPPPKPNPLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSA2</accession>
    <name>W3VSA2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSA2"/>
    <dbReference type="HOGENOM" id="CLU_061316_1_0_1"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="91"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="334" mass="36331" checksum="95D03001E3D00763" modified="2014-03-19" version="1">MTPKIRCGYVPEHFAAPLLQLADTAWGKEHIELVLQPSGTGQMLTSLDAAQQGGQKIDVAVALTEALITGIAKGREDYKLVGSYVRTSLNWAVITGTDASADKYRSIDDLKGTHIGISRIGSGSQIMASVMALNHGWNASSDPKDRAEIEFKVNDTFQNLRNGVNGKEPWTSSCFMWEWYTTKPYVDSGEVRFIGSVPTPWPSWTIAASTNTALAEGDARGAVLAEFLSRLQQSIHEFANPETRASGKAKQFIVNHHGYKEEDVESWLNTVRWADEQTPNSEGLVVPSTGQDTNTRSVSAGTVKHTLELLEKAGVLKAGIDPAKFVDSPSRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSA4</accession>
    <name>W3VSA4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSA4"/>
    <dbReference type="HOGENOM" id="CLU_089365_0_0_1"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF162">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="310" mass="34437" checksum="61E280D46F35581D" modified="2014-03-19" version="1">MARKTTRRSTAKQAEGEEPDEPTTSTGSDSDFETDDVIDTAAAYKDAVNLPAHQTKHLSELVYRIPRIDTAFQLVQRNDTNSTGSSLWLSSQVLSAFLLHTYAKPQLRTASNVKRKRMLELGSGTGLLSLLMARLGWDVVATDIEPVLDSVLRPNIDAGLCQLVNEGHADPEQIRVCKLDWTAAEECKTGSLRDTISGMDSTESSGTSGEPRLDLIVTADTIYEPGLIRPLLSTISHFYRRQTDAKPTILLALERRDPAHIDHALQIARDEFDLPLKQIPAKRIRKIFDTLGDGATWSRDDWSGVEIWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSK4</accession>
    <name>W3VSK4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSK4"/>
    <dbReference type="HOGENOM" id="CLU_012923_4_1_1"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="477"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="85524" checksum="B4C31073D3154F2E" modified="2014-03-19" version="1">MPSLNLATSWPHQLAATMLAKQPEHKSPEGSGSGRSLPTSLLVTSTLAAIFATIFSFFLIWKQLKNYRKPILQRYVVRLLLMVPIYSIASVISLYSLELADIIDLFRDLYEAFVIYCFFNLLIEYLGGERSLIVLLHGRRPQQHLFPANLFLHDMDASDPYTFLALKRGVLQYVQVKPVLAVATLLLKAAGKYEEGKISVSNGYTWVSFTYNVSVFLSLYCLAMVWKCLNSDLKPFRVTSKFLCIKGIIFFSFWQGLGISILVAAGILKKVGPVYDPEYISMAIQDFMICLEMPIFALAHAYAFSHTDYIDPFAHYAARLPVYYALRDCIGMYDVFSDSLTTVRGTGYVYQTFEPSEGVIHQPLARERRSKAGLRYTQGGKGKYWLPQRGTGDIRDATQGARHQGPLKKLRRYINDKRMQLEGHAPLTPQEAGEIVHEDPDLEHQESSERSPLLPHPKKVARSAVRHAGDGLDFFAERQLDSDEEAEDLGFDSPDEEEEEAYERSRSLHFGDYAYPNIDITREQARHSRWQQDDEIVHRRRRKDTLSKKAKSEPTQARPREGGDDAAQGETNGEAQRDEQAGSSKAKGKAKVSDESAKAPVKEDQEGQQTNSKSQDSKTTQATEAKADAPSDPKIEAKEEDPYGAVDLVVEDYKAEERERLMERRRGDPALRAGGTRIFRKKYTPSPNASRSATPNPDQRTTSNSQTHKNSDAQDTQMDRLLSTRIDVDDNETFLKGRSLSPLGQNAKLPDSHDSNPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSN5</accession>
    <name>W3VSN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_01036</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSN5"/>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="292"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS64569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="621" mass="69080" checksum="3FB70F30BC4B0577" modified="2014-03-19" version="1">MPTVGVDKERFFQALGRTYTTREFDELCFQFGIELDDDTTEEVQKAGLGERPQLKIDIPANRYDLLCHEGISRALNVFLGNIEQPQLRLTQPEKLIEVKVSADTAKIRPYFAGAVLRNVTFTPESYANFIDLQDKLHQNLARRRTLVAIGTHDLDTIQAPFSYEALPPTEIKFAPLNKQTEYDAAQMMQLYESDKHLSRYLPIIRDSPVYPIIYDQNRQVLSMPPIINSDHSKITLATKNVFIDTTAVDETKLGIVINIIVAMFSQYCAEPFTVEPVRVVYADGTQKVTPDLSNVRFDASVEYINRCTGLALSADDMVGLLRKMGHTAAVDASDAGKLVVDVPPTRPDILHECDLMEDVAVAYGFDNLPKTFPATNTVAAPLPLNKLADIVRRECAYSGWVEVLPLILCSHDENFGWLNRPDSGKEAIVLENPKTAEYQVVRTTLLAGLLKTVRENRKHALPLRTFEVSDVAFQDAEETERCARNQRHVGAVYCDKAASFEVVHGLLDRLMLSLAVPRISGAAAKETKGYWIEQAEDATFFPGRAATVHLRTPREKVNPGAATGAKGALETVKQTLEKVLPGNEYTDEKVGTIGVLHPSVLASFGIDYPCSALEFNLHPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSQ2</accession>
    <name>W3VSQ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_01051</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSQ2"/>
    <dbReference type="HOGENOM" id="CLU_041822_0_0_1"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="272"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="367" mass="40473" checksum="35F91E0B99C3AAA2" modified="2014-03-19" version="1">MPPKTAASGRGRSQHTRNSSITSQRDKDEGEPFHPAADAATFRDLLIFEERLKQNAARLQARKRKYELLLAGFVGFILCLSHFVVVSPRSSVFLQYSLAAVLMICLTTLFLFFASGMHAERIRSANKFVPQANRSLRSFNMYLNTRTSASSRWWSLRRLLRPDQTAKSTSNETGSLVSMVDKALSRGTTMSKSSSRLSSGASSPRRAALSSIPPSQNSRGELIFSNRVSPDFREGYERYRAAFERRRAEKIAAKRAQSWKRWFDYLLARNSTQPADDSTAKRTQARSSRPSAAHSHPTRSSKHRPARSGQSTTQPDSGNEMAAASDDAAPLHSLNAHGEDLSEGGLSDDGYPPSMASGSSLSGHEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSR9</accession>
    <name>W3VSR9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_02157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSR9"/>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="59"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="432" mass="47434" checksum="23467FE57FF9055A" modified="2014-03-19" version="1">MLAPATIRTAVRASQASRLGFVSLPAVRQYKSTWAHVKAGPPDAILGVTEAFKRDQDPRKINLGVGAYRDENGKPYVLPSVRQAEELVITSKGDKEYLPITGLADFTKNAAILAYGKDSAPVKENRIAITQSISGTGALRIGGAFLQRHYPEAKSIYLPTPSWGNHTPIFRDSGLEVKQYRYYDKKTVGLDFKGMIDDIKAAPAGSIVLLHACAHNPTGVDPTVEQWKEISNVVKEKGHFPFFDMAYQGFASGDTDKDAFAVRHFVSEGHQIALSQSFAKNMGLYGERVGAFSVVCADPDERARVDSQIKIIVRPLYSNPPMHGAKIAGTILADQQLYQQWLGEVKGMADRINGMRSTLKNLLVEDLNSKLNWDHITNQIGMFAFLGISPEQVAKLVNEHHVYLTGDGRISVAGITNHNVKHLAESLHKVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSU7</accession>
    <name>W3VSU7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_00649</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009442_0_0_1"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000117">
        <property type="entry name" value="Ferric reductase like transmembrane component-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="645"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="409"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="561"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1006"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1087"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1007"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1062"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1126"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS64698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1320" mass="145256" checksum="71E630BB396C1CC2" modified="2014-03-19" version="1">MSSGGAYSPGVSSSGSSSSSGGCSGSCFDPDQLKYQYLQGYFNAHMLPAPSYRYVYLLWFVTILVSLVLGSFHMLGLGDRSYIGAKWKRWATKNRVYKLGKRLDIHGNPVHKDSHGFIRAYAPLKPRKMLSFPSFGRLVLLFFMIAVPIVLTLVGADFIGPTNGVFDFSQSWPPQTTNTVGMSRRALRLLRRRIIWGQGAYPVVTTYPPVRTLPYRTWWTTGDRTGDITMGLVPIVLIMALKQVPFALLSTRFFGGYAFDRLSFLHKWGGRIIWLFGTAHLVTWCIQLNKDTRIGEPVWSFVFMWTKFRWGWASYGFLTAMTFLSIGPIRNRFYEWFYIAHVVTVAGFIITAMLHHPPLAQWMYIPLAWWVAERLTRALKVAWINGLGFAGRKPQFALAPKPQMSHSHSAAWSEASYPHPQRPPMPRSPYAHPSFGPGPQSYHYHDDKPHTPNSHHASHPPTAFDGSSASSHRHAPQSRRSSEYEHTLVESLPDADSRKIWSPPPLDGRTEPMTSGAAHPLEARHEHSPERGEKALERRATRASARYDPVNDLIQDYIPSRHSNADVYPPPPAEPLPALPQQYASQSSYDAKYSLQDPADAPHGSTYPPPHPSRMRSEPSSAFSARPSTMFSVMSTTMPRQLRPRPAMSADVAAVIRPGFAFVQLLPGKTLRLTLRTPNKMSWQPGQWVYLNIPSVRFWESHPFTIASAHDADFPVATEFVDADHEKGLAVQKAKGEERTMVLLVRCRRGFTRHLWNFVAKKRQMQIEAAADAQHGASAYGMPGTTAVPALGKDTTGVHIRAIVDGPYGSADRTHWNIHSTVVIVCGGSGVSFGMSVLEHLCACMVGAMKFGKDGKGGKHFLTKRVRFVWIMREFSHLQWVAAALRRCIEMLPPEHLQVDLYVTHFNHRSALADAARGASRGGRSQDFGPPPSEFGANTYDSRQRWGAGAEADGGFSKAARFTEGPEQEEYDLTAYDLTHFDGEDQSAPTAMEEEMNKRIRTEGKLRRAKTRRNTVKRKGGRGAKAAPAELDRDEQRAMYEGRISSGRPQRLNAAPAPERPSYPSAGPGAAYPPRRAVAVEQDLADGVEGDNDSTWLPAQAGRLQPGGAHMGGRRTTSPPAAPYGTTDSNLGPLSAYMSPSASRPGSANDELVPPPAFGGGGASGSSTPRFAASPLATPYSASFDAASHSGFLAADDTEALRGSTPRNGSTLHLLNTAVAPVASAKSPLEDAPIDLDAEEDVDLRVVAELAQPGHPKLDRIIRQEVDRTEGRTLVAGCGPKSLDIVLRSIVSKQIDPKKVRKGDTRGVVNVVSECFEWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSX1</accession>
    <name>W3VSX1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSX1"/>
    <dbReference type="HOGENOM" id="CLU_008926_1_5_1"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150143" description="Endoglucanase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="11">
        <location>
            <begin position="55"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="598" mass="64246" checksum="844A4B0370892044" modified="2014-03-19" version="1">MRSMASAGALLALLHLAPSGAWAQITPQQVYQPPPASRGAVSQQSNLTNGVNPQYADLLGNALWFYDAQRSGALPADNRVSWRNSSCENDGSLNNTDLSGGFYDAGDYIKATYPFCWTLTSLAWSALSFGSAYERSSQDAYLDSTLRWGLDWLSKAHSDADTLWVLVGNPSTDDQYWGGDQDIPGPRPSYSVTRQNPGTDAFASCAAAFAASAYLYGERGASLPTSTDGAQLGGVSTIHNRTYSEALLRHAEGLWDLAVNSSPKQVYNTAAPTAGQSYPSSDYEDDLAFAGLWMALAKADASYANQGLVFYPNGTNAFASVNSALNWDRKVAALPVLATQLAQHNASFGLQMSRFQNDAESYFDRLTSGKMQYVSQTKGGLYWWAGDSDAASLNPALNAAFIADLYSGFATTSAKNSAYRSLADSQVDYLLGDNNYNGPFIVGQHPNSPQNPHSAMAAGGNDITNINTSPPQELHVLYGAVPGGPDKQDRFFDIRDDWPQTEIALDYNAPLVAAAVSRIARNVTKDPPFATLTGAANVASGRPTDAAYPARKKGGLSQGAQIAIAVVVIVVVFAAAGALSWWQRDRIRWYYRQKKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT99</accession>
    <name>W3VT99_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00811</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253069_0_0_1"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="747"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="837"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1212"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1316"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1359"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="897"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1365"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1383" mass="149005" checksum="0396030956596E76" modified="2014-03-19" version="1">MRESNFCNPAQNKASVCISSAVYDRRAIDCTATLPLINSLNHLAYLTSTSPRIREMVTLDGGLERLIRILRTVPKTPSPQARAFSIKEMQAVWKWSLAFQCVVNIGVRGSESVRTRVVEAGMIPVTIRVLESYLRNMERLKDEKRKDSLLHHHRHEARRDDRATRERVQSASASNAPLSASADSSRSRRLHPAPDALAPTSNAAAQRNGTASSASHDSPTLQRTHADAQPVSNAIAPTNLPNHLLTETRPTTPLEDPVAARRSSVFATMDAQSSADDFMPSQPPAMPVVDPHEPHAAMPLIESIDPISLSSSGSPPNVGPDGTPRALSSARADDRNLEGMSSSEDLRSHAAEASGSGSDGAEDAEMFADDADDSEIDVAQFQTVRSTDSDNAPSSAPSNIEVDEDLEERRTPRPARRALAPLSGNDSPPLPAQSYVTPNRPTSAVAPPLFERQDTVRPSRDFSTTAGSREASSTNLASTALAAQVGSQDASTRSSSLFDRQQQPAHQHQHQHHHNHERLHHQQQGSASQDQRHHHHHHHHHHHHHHSQPHDHTHQSRASATTSHYDDVQMGRQRSAHPEAQQQTTPREEARTTAVRPAQPAFDAGAAHPAVVQLSNLADTNARAGIDVVYREEEVLLSLQLLAYLSKYPHVRMLFHSTDFSGPSLMGPLDSLNEEIEQATKRNKSWDPAEPPRRNVFAIAEKFTLRSRNATHPAPRLSMEIQYWAGVIMRNACRKDESRGGIRQCANMLCGKWEEYPREFAKCRRCRKAKYCSKQCQSKGWQMGHRYWCSAKSDEAEAKDKEREKTTEAQRDGRQEDGGAAPRIVPMAAHAGEAAAFGHGLPDEPVDAMRDPGARGGLGRTDDMQLDGMDRHTAAARRRASGEPAEGSAHAAVPRSGDGRSRPGPSARDREDGVQAAAFLPDGSQGRHSGLDSLAHAAGFGRPDSGMMHEANGAAPSLNGHGTQASAEYQHGGPSRMHRQLSSSASSVEAMGVNGHAASGEDDAWTRGAAEPGAPRLGMLPSPYASATGALDRGVGSAAHSASSSRTSLGEGVAEAQRGARRGALPGGMGLPTTMLRQDLRDRRVTSLASLDTVDGSDVSEDETERRLAQTQDIHPALAAAAAAAGLRARDGQVPPQAPQRTDLAGRPLPPPVIASQNGDEDELALGGRATPGVAGDQDFGTGEIDQMLGHWATRRPDAIGLQQRLAEVRAEMPSPERSLSPEAGVHGGETSETVMGARSDDEDLTATSRTSRYGGLYRDAAFGPMARGQTPQPHHRLHQPRSASGFSAFGGHATRFGYGESMGETSTLQGYRPSMVSSPLAQTPARRTSGHGDSTSQNVEDIAMTSEAVSELSRSAVHSRLASLDDDMIDDADDRDDISMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTA3</accession>
    <name>W3VTA3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Regulator Ustilago maydis 1 protein (Rum1)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00816</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000991_1_0_1"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15543">
        <property type="entry name" value="PHD_RSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000016">
        <property type="entry name" value="Putative Lysine-specific demethylase 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="12">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="11">
        <location>
            <begin position="294"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="537"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="13">
        <location>
            <begin position="702"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1421"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1669"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1584"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1782"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1846"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2003"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2090"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2165"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1600"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2003"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2090"/>
            <end position="2101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2183"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="2213"/>
            <end position="2242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2274" mass="249171" checksum="1CC19F75269D38B8" modified="2014-03-19" version="1">MTTTKQGSAQNGAPSSSSSTDSVPQRIIVKSVNGHEPIKLEPTSSTSASASRSASASAHLATPLSSPTKSNGTSSPSKSPTKARRSQPIIVSSREFGPSAGGDSDDDSKDGDSELTKGPSVKRLSRKSKSDAMSAIAGKELDDPGSAPTAQHAPVAPSGNPALHPARKLLQHQSFPPLVFDTNPAPPTPSGSVLDPQRVAIPTSIATPRRPPPRLRPRLFELEEAPVFYPTPEEFVDPMKYIAWVASPQGGNAKTYGIAKIVPPEGWNPECVLDEQSFRFRTRVQRLNSLSADARASQNYQEQLQKFHAQQGRKRVSVPVIDGRSVDLYQLKLIVSGLGGYDAVCRARKWSDATKQIGYNDKDCAQLSTQVKAAYTRIILPFEEFMTKAKEQTRAGAASISPNLAQSATMGSVPSGDTNDASLHNVSMSPSVEAADRNVQSHTPEPLGAAGAADLLASATSAVDSATQSPSTVASTRRSARKRSEATSTPASGSRNPLQLASSPATPLASRRRKGVSPLVDTDPHARAATGNLGAEEQMCEICLRGEDGPNMLLCDECNRGYHMYCLQPPLTSIPKSQWFCPPCLVGTGHDFGFDDGETHSLYTFWQRAEAFKREWWSKRPDRVWTPDEADAPEANVERRTNGLARRIHGTDLTVSEDDVEREFWRLVHSQSEEVEVEYGADVHSTTHGSALPTQETHPLSPYSRDKWNLNNLPILPGSLLQYIKSDISGMTVPWIYVGMIFSTFCWHNEDHYTYSINYQHWGETKTWYGVPGEDADKLENAMRKAAPDLFETLPDLLFHLTTMMSPEKLKKEGVRVYACDQRANEFVVTFPKAYHSGFNHGINLNEAVNFALPDWIFDDLESVRRYQHFGKPAVFSHDQLLITVSQQSQSIETSVWLEAPMQEMVDREIAKRNALREIIPDLKEEVYDEDVPESQYICAHCTLFCYLGQLTSPKADGVACLDHGFEVCNADAPVKWTLRLRFSDDQLRSILAKVSERAAIPRNWIQRLKKTLSLGPNPPLRTLRTLLHEGEKIAFSLEPLEDLKAFVTCANSWMDRANVFLVRKLHKRRGEPTQAPAVRGRRSKGGASGDDSARRVSIDASAEDPDSVADRSPEALYALLNELDSLHFDAPEIASLRALVQELEEFVGRSNEILRQRKESEPNLKDCESVLTLGSSLNVDAPQIKELSDYVERRKWVQEVSESRDAYLYYHEVEGLLERAESCGLTDHELRKELEQRREAGARWTGRAREALEGDAALTIGVLEELSEASAEIPVVLEVAQDVSNALTKAKELQKTMQTLHKSLQAGAPTPAAVDADGDLSMVSISENSDAANRLALLPDARRAVRAVRSNKLELEHAQEIEEAIQIHDSWRVAFNQIMQSVAASNRRFTDADRDAELDKMVERVENTTDPSDDQPRAESRTCVCRSSAPIAVPSSSAAECSRCHVRYHLSCIKVRASEVSRADGGWTCPFCPWTGNAAFLKARRAVSVTELSKLVYDQDHRRDQFRFLPLEWDAIEEVVAKAKRFEFAAKRMIKTLSLMRRDQKQAILAHWLRRSIGCPVDVLGPEKINMLDLISETLLALGPDPADERPAPSAPVRPKLETPTRSEDRNEPAAQHGSSSRPGGRGVTDSASPAVREDRKRKAKRGKRAKLVFREEIGLGAYRDRQPIYCLCHEPESGRMIACDKCMLWFHTQCVRLDDPPNLGDEPWICPMCCIKAERKYPQAEVRVKEMGVTDPDLWLDIRATLRSLEKPVSKLQSWSSREDKRIVLHLEKFTPAIHAEEVHSQGTKRARLESDTPSKARPSVGRSDSISTPAKDSGSLPYAPAPVPSEAARGIAPVPVPAAASQAQLPPADGPVPKVVGGDESLGPVSPLQTEPKAVPSPAPGGFDWAQSARRRHAEGMDNLYRRGITDAMLMRFYVGWNGRVLVHPMLDATGAVVEVQLGEAIRLHADDPEGVRVIRAAIERHNARMERSAAAAPGVMRAYGPTDDHAAPRTPYAREEMLPPPQRHEQPMLPSHSRYSGGSPGSVPSHVAGDRDGRYIEPELRAMRSPAAGVAAASPAMRSNVTHEPAHSYVRGSATPLVGSNGVASVSSSYASGPRHASHSAYSSERDYRAPYPAPSHAEPEGARTPALMPTYATVKPEQLTPGVGYGALDPAMMADDASRAEAGSEGAPAKRASPAQTPPVAQARAVPAADEQAAQDGKMAEPGAADKHQGPVPAEPKKENGAAEDLETVREQARNMARRMRPDASDAEIERLVQNFIGGTDGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTC2</accession>
    <name>W3VTC2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256068_0_0_1"/>
    <dbReference type="OrthoDB" id="3360637at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="871"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1310" mass="137855" checksum="074274A0E3291262" modified="2014-03-19" version="1">MSSDQSASRIGASSSEAQSLGDESPSSPVQPPDQHDPQTHKTLSYVAKGKARASDEDLAASLDHAAQHIQHAMNQLSISTTQQTSQPAEPTRRRTRKGRDTTSRSVAPIPLRSPLVTSPTTGEASQFVSLLGQPVAVSASLSASDKPSATAASAALPSLYKASRGRSANVSPSRRWDRRGASASVLSGASASGSGGEGDDASEEEPVIPQPHRRTARPLHRSSPLRNSQAIDDKASRRLSIAKEEALFPSDEDDSPLLSSTEDLDTTHGNRNAHRRRSRRWSSIERERRRGMRILLQQRPSDSQDSALPPTSRLKSSSRERARQTSHLSRTSDDDASDLESSCPSSSASSCEFSYGHNASETPAIDIKERSSRSSRSSAQCEGVANASTDGASSHDNLPSSTDGSDRPSPAVSTPSTSLVQRSPPGFTALKPLVPIPVTSESDPLGHIVHSIEDMIQVDKVEFFPEETIAAQHSASRTKRKASPKHVKKSSWIIGDFESEPEDDEEQAPGSPPQNGNPVHGQSLIHAHAAGTSPPSPSPSSYQARLAGLQNQLRIWSRAPDEAAAPRVRQTSSGSEDMTEAESEPSLLSASWRNLARLPNLILLPGLAARQARESLASAAKVSGDAFDSSSNDRHLTAAAENDFAQIYRLASAASASDERGLQTQRKVALKTGRPPSPSPSPSPPASLLGSRQSSNDSICTTDKGSYTHKLDSASRRGRGVASLPEADRDPSAYVSGLGQPIDPDTELSSVVQLQTFRSRSRSRPAAGVGGRGRATDRPHRDAQHPGADGDKEAGATGATSPRKLGQPIELQPTEEDRATEQALRPHKAERPLRSVRASPGEGLTVDVGGASAKSYDRSGLHRPDPFSHGPAPTDTASAPTSPTFRKGSSSSASSADEADVTPPRSRAADKASDTAVDADGFRVVRRKHRRTSSGPRSLRPKVDAPVPHGFSAFDIKEDDENGEGSDSDGEVTPSPSRTRSGRSRRGRDTSPRRSSRQCAVGLFGGGVSAADSASSRGSSSRSRRNSRRDGSLISVSTPIRSVRSSPDLTYAAAAATARANGAEGEAEQGADDDPSPPRGSRGRRGAVKVVASSIGQQGASMAQPLLMGGLDGLRRGPSYPPRADEILDETASGIDGSDDEPAASQHSTPSGRGRSASSPGCGGGAAQGLRFRLLSNSSHLLMLSLELDMIKKQKISAPLKPRWGKHRADDFNPLPSTVACTSSAALFASSQYLRAPFSATEGTNCADEECGGSTCGAPEKIAVPGRSSRTSLAAIHTLGGGLRDPSSRLRFSWSLADIAAALEAAPSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTK1</accession>
    <name>W3VTK1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTK1"/>
    <dbReference type="HOGENOM" id="CLU_010778_2_1_1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="659"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="690"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="75103" checksum="0C07234D893A11BA" modified="2014-03-19" version="1">MSQVPPLSQGAGYGVVIGLGALFAIVVVGISRSLVRYAGISKDAEEFSVARRSLGTGLTAAAVISSWTWSTTLLSSVSTAYNYGVAGAMLYASGNCTQIVLFSTLAIQLKRRAPSVHTYLELVRIRFGVLPHLTYIFFALATNILVCSSVLLGGAAAINSITGMNVYAALFLLPATVVAYTLRGGLRSTILADYLHTVIIFVILFIFWLRAYATFPEIGSPAAMYDKLVSASRNISVPGNYDGSILTLKTEGGQYFAWLSAFEYTGVVFLDASFHQKGVAAMPEAAFPGYLIGGLAWFSIPFCLATTAGLAALALETTYPGFPTYPNRIPKADVSAGLVLPYAAQALLGKGGSAAVLLLMFMSCTSAISAQMVGVSTVVSYDIFKTYFKPAISAEGLLRSNQYVVVGFGLFAAAFGSLLHGIGLDLGLIYNLTGIFTGAGLSPLIFIFFDTRLHPAVVFPGIWINFVAGVAVWLSVAWHNYGVVNLASVGGVVPCLAGCGTGIGVGLVLSVISVLFFPRDFAWSRIPEILEEQHRHAQQLRGEKVAERTQVDEKAASSASSQGETTLELIEHDPSYDPKRLDRSFRIAVVSALTIFVVITIIWPFSLYRDYIFSRTFFQGWVTVSFIWAVAAFVGVGIFPLVQGIPVAKTIIHNLKNKATRTSDKQQPASDAASPTESSTPASPNESKTKITQSHTDSNYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTL4</accession>
    <name>W3VTL4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTL4"/>
    <dbReference type="HOGENOM" id="CLU_545347_0_0_1"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="4">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="444" mass="46889" checksum="7544F9C41A889D80" modified="2014-03-19" version="1">MAFNEQPSNPVPAEADASTGAGDAANARQLIDESRRHFALKEYAQAIDKVAQALEQLSSHHAEDADELAPVLHLYGRSLLENFIVNSAALGGGGGSAPLPAPSAPSKSAAVESAPAAGGSSKPSTSNAASSSASATADPRFSFSGDAEDDDEDDDEGAAGAGANEDDDDDDLQVAFSVLDLARVIYERILAADKPELTTLEAQQWGKTRIQAELAEVLNHLGDVGLEAENFAQASADYEASLQMLEPLLRAHSRRLADAHLRLGLALEFHPDIDQRKRAKQHVQSASQVLASRIAAIQARIDNPSAAEAKEDEGKERDDLVELDAAALKTELEDVSGMKREIDTKLDEYDTEDGQAQLSGQPDLAGVLGLPAEATAAAGMTTKDALQQAIKDAFLGSTDDNDVNPFTGAKTASSDAPVNNLSSMVKRKKKDDSQEADKKQRTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTL7</accession>
    <name>W3VTL7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00786</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTL7"/>
    <dbReference type="HOGENOM" id="CLU_013528_3_3_1"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1910:FF:000005">
        <property type="entry name" value="Cysteine-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000275">
        <property type="entry name" value="Probable cysteinyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005377780" description="cysteine--tRNA ligase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="14">
        <location>
            <begin position="101"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="816"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="769"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="824"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="847"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="871" mass="96358" checksum="EFA87656AD73B39E" modified="2014-03-19" version="1">MSSLFRAALLSSRSSLLASLAPTTRSTLSARPLAQPHPPGIVRALSCARQSNLVMAAAQPESSSSAGAKISQPEWQIPQKQVPEPELKMYNSLTRSKVPFVPKKGRTVTWYNCGPTVYDASHMGHARNYVTQDIIRRILRDYLGYDVHFVMNITDIDDKIIIKARHSHLVRQFRAQHPQLTKPLLQTIQDAWSAYFAKNLERFAPPVPPQEQQGGLVDQAEKARAGEAGFEEIARLRQDAAWLKTASEKEPKFGMWFSALDRSRQAQVAAAMSLAASDSSPEAASNLIDASEDVLAAFLDKQFGSTVTDPAVFRDTAAYWETQFFNDMKRLHVEPPTTLTRVSEYVPEIVTFVQQIIDRGYAYAEGLDADKKNVWFDTRAFDGAKSSDGSFDHSYAKLQPWSKGNRELLEEGEGSLSTSTTATAGKRAASDFALWKSSKPGEPAWPSPWGPGRPGWHIECSVMGSAVLGETMDIHSGGVDLMFPHHDNEIAQSEAHHGCRQWVNYFLHTGHLHIEGLKMSKSLKNFISIDEALERFTARQLRMSFLLQPWHGRMDFKQSALGEVKNAEAAFNNFFVGIKAKVAEAKALGDGYSDGQHHYGDKEKALMQSLEDAQHAFRLAMCDSFDTPKGMEVLLDLVSRANVYEKSHEKRADVNLGVLTAVARYTGDMLKMLGLGEGAALSAASDLGWGVADDSVDGASAVNKEELLLPYLRALSTFRDAVRKLARSGAPASDYLKLSDALRDNDLVDLGVALEDTEDGKALVKLVPAAQLQAAKREKEAAAAEKAARKAQAAEQARLKRLENLEKGRTAPEQLFRTAEYSEWDERGIPTKDKEGADLAKKRRKNLEKDWDKQTKLHKDFLDAQASGEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU17</accession>
    <name>W3VU17_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU17"/>
    <dbReference type="HOGENOM" id="CLU_446307_0_0_1"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="613"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="683" mass="73573" checksum="6F373EE43A9F6558" modified="2014-03-19" version="1">MQASEAMLPAAPSGSDALRRLIGGYLALVQSAPQPRDQLVRELEAYKDVKSYLLALGQQLAHDGSLRTEFAGSEALVSLIGCIGTLYATFEQVQSTRPNSQMEDPDPLQAQPASTEAKEQSADPYYRVSHIATLCLRALRNALAGCAEAQSILCSRFDNVAPLLTNLTRFHTLNDPDTLLLARAAIQMLSNLITANEEVQQLMWPRIVMTSQPEHKLALNFLSSPDTATQSAAQILLINFIRAPNGNADARRRCMDLCTLTEGLSIVETLLSASESIMLRTASVGTNGSINDYDPEIETERLEESLGFIYTIFSILFETGHSSMLFAALSPLDEISLAANGSVPSEPVVISSSQLILLKLLDSWLHSSQQQAAISIDSSSTPGPSRTGGPTMAHIAPETVSSNAMDVVGGAGLLGLLDAFAQLSRFARNAMARGTAKDGADADAQPQDRRLIGVHHALLLVLQCLLSVSMTADGWSDASLSPEDTVPREDLSFSALSVRMLSSMRSNTAFVDELVALLDQTHQYAPALSPFRPTKPADGSQPSGDAYADRPMPEGHALSSTGLAGRDAEAKQAGYGFDHLKRDIVRVLGSLVYAPTRADVSASASEHTKTQIRQVQDQVREKGGLFHVLNMTVLDERNPYMREHAIFALRYLLANNLESQKLVGSLQPAQPQDGSVGLQLPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU46</accession>
    <name>W3VU46_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="1">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_00483</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU46"/>
    <dbReference type="HOGENOM" id="CLU_011276_11_1_1"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000003">
        <property type="entry name" value="Putative Uroporphyrinogen-III C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="14">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="13">
        <location>
            <begin position="369"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="489"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="279"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS65030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="884" mass="94443" checksum="35E8519F4E2E7477" modified="2014-03-19" version="1">MSLPATDQAATAASTSAYFARPNPTASLLLSHRPPAGKLVLVLGTGKLAASRCFACLEAGIRPVVLSVAASPANQACAEIQHRIDSAQALHHSIESNALSTVDSVEQCWNHILDTYDGEDNDIFAVCITDTLHSGDEPSASASTASRNKPSLDGDDELLDTAAPLTSYARAEIISRLCRKRRIPINVADKPNLCDFSFPASYRFPCTNPISPLDSTGDAMLQIRSTEVVFSSSLQIAVTTNGRGCRLAGRLRREIVSALPHNVGDAVEKVGIMRDLAKRQAEKPQDASGSAAATVGASASSPLKRLKRNAARAGKDGTADVEEEDLSFDTTPLNSPVPQLVPKNPLESVTTNARLKQLQVEIQARHEQEAQQAEERTKRRMRWVAQISEYWPIEYLGNLAEQQMKDALRAHGEEQSAPVPPATTAVGADATQHREGQNINEPSSRGRSTAPRADQDASAEPSASLAQRARSQHSLDIRPPPPETARKGHIYLLGSGPGHPGLLTTMAYKLLTSASTDLILSDKLVPAAILRLIPQSTPLEIAKKFPGNAEGAQSELVAKALRAALEEGKTVVRLKQGDPFVYGRGGEEVLAFRRAGIECTVVPGISSSIAAPAMLGIPVTQRGAADSLVLCTGVGKGGKKVKLPGYDRGRSLIVLMGVARLAAVVATLTAGGSLGAVDADSIGDREGAVFPPYTPIAIIERASSSDQRMVASTLDGIVEAMENTGEQRPPGMMLIGWSVLSLEGDGDTTIQDDALTIESEQQLEAKDRERVQRWLKGRRWIVREGLDQSYRDALAAFHTAPLQLPAVALTHHQDEKAQVAGADAEDAERFSKRDESGWAPARYATGVPEGGWMAGEAPNRPATDELAYEQDKTYAEIQAKLRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU87</accession>
    <name>W3VU87_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU87"/>
    <dbReference type="HOGENOM" id="CLU_278630_0_0_1"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="660"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1109"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1134" mass="120329" checksum="94EAA9F86F9E78A7" modified="2014-03-19" version="1">MSAARSAAPRLRLLQSGAPSKRLLHASTSYAAAAPAASAASSSPASDAAVSSGSSSTKIISSLILSRPPVLLREPTKFERAYHEYNRQLSEALQQPFPKDFYFKKGSAAEKRFEEDQASSPQGFSAIAAEASKAASKSAKGAKSKDASASSSSSAATADGEAESRPLPRTTEADAKNDVRSLERKLDRTLYLVVKQKSGTWRFPAKALNDTKHQNLHDVAPASVTETLGNKMDIWLVSNLPVGLYRAADAAAEKTYFLRGHVLAGNAELAKGKGDVEEFQWLTKEEIQQLMEQGKNASYWQNALARAAALLQAELTVHEAQRVASAGGSNLQAIWRWTRSPGRGSAKPCLAAQLEPFAPTVANRHARALHCNATPACRPASLQHHSSAAAGTLARQVAGPADTIALELGSVVTGFQAKLRRSESDVTPLHRLSVHPPPSALESSLPRTPTRTPKTRQAVLAKDRPPSAWLAAFPTLNQASSLFQRSASTANHWAKKGPTIDALTANLQASSLNDHHALSPQAFKKLLLDNIDEKADTIPAAILSGPDDAKSIASVGDVAVDADVAAPAAPAQGLPKYIADRVAYEGGEFVLLIGADASNPDSAEHFRFNDEELAIAIANVVKASNLSDADASVLDQRSLDDGSRSAHVLIRRIPASAEELVELRIAVIGNVDAGKSTMLGVLTKGGLDDGRGKARVNLFRHKHEVESGRTSSVGMEIMGFDSKGKPVHNVAGPGQEPGRKMSWEEVCAKSSKVISFIDLAGHERYLKTTVFGMTGCLPDFVMLMVGANAGLIGMSKEHLGIALALSVPVVVCITKIDMTPAHVLETTLKQLTKILKSPGCRKTPVFVNDIGQVVDSALRLESERICPIFQISNVTGLNLDLLRSFLNILPQASAAKFQVNKPFEFQISDIFSVPFVGTVVSGVVLAGSCKVGDSALLGPDSLGQFVTTSIRSIQRKRVNVDGATAGQSVSFALKKIRRNQVRKGMVMVARTDVAPKSYMEFDAEILCLYHSTTLSVGSCMVLHAASIRQTVRIVGIAKLDGKPTLGVGAGAASDPAGKPVVRTGDRAKLRLQFIRYPEYVKPGMKLITREGKTKLIGVVRAVGQTGPLGGTPIPTAAQANVPPPANPAPALGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUA9</accession>
    <name>W3VUA9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUA9"/>
    <dbReference type="HOGENOM" id="CLU_028984_0_0_1"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040684">
        <property type="entry name" value="HMUDK_hel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18723">
        <property type="entry name" value="HMUDK_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="467"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="578" mass="65005" checksum="D26A90B7213D5973" modified="2014-03-19" version="1">MTDPTATAEPSLKRAHHDDDHQSPVPSSSHLEAASSSANMLSSEKGAQKRPRLPISTQVTKSDLPSPDANEVTILPGLVLPLNEEVLRTFFQYSHDRHDVFLKRKQGKPQEEWTDDPVFKSTKFANVYRVLDRLTQYVLTRVVQDGPQQLEEVCFRVLLFRSFARISTYEVIRTALGGPPTLASFSPTAYENFLMPHISAGNPVYGSSYFIPAPREFRTKYPYQSTLRLVHLMMRTGLPRRLADLHHMRDAHALLTSFPSLGPFLAMQLLLDLNLSDHFDFSEEEFAACGPGSKQCLVDIFGKYVSGFELEAMRWIQKEQEHYWGKYGITDVPHLCPARKPGLNVVDIEHTLCEVFKYRRARGRMEAPARNVRGSKRGRRGRGAARATPAAASPARGIKQEDEDGLDGLDFERIRSNGSKTSGQEKVKSFVPTGNAVTGELPAKWLVPRAPEEYERPPPLDRSEDVYEVSHIVAMTPTQSKCLVRWKGFGPDDDTWEYFDELLNGGAKEAVEEYLKWLRTVKDEIEAMLDEEKSNREALEKMPAVNMVSSVIKASPEPHGLGTRPALPFANMPLALPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUH3</accession>
    <name>W3VUH3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUH3"/>
    <dbReference type="HOGENOM" id="CLU_000604_57_8_1"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002389">
        <property type="entry name" value="Related to ATP-binding cassette, sub-family G, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF122">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="119"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="739" mass="80913" checksum="8DBE40C6A8476515" modified="2014-03-19" version="1">MAAATQPLTGVVSSPSTLGATHNMRSASSLSTPAPNSVNEASPSSSRPGPSHTSVPAGQDVFSWRDITYDVLLSKARRKHIKKHGTAAAPVEKASENEKALEAENGSFSPAESDEVQLAEQQDVFPHLPPLDPMRRRVLNGVSGHVKRGEMVAILGASGAGKTSLLSVLSARLDKSSEIAGEVLYQAKPRDPATWKRLTGFVEQDDLMFGALTVTETLQYSADLRLPKRLYSKQERRQRVQDSIAMLRLEKCADTRIGGPNQRGVSGGERKRVAVGTELVADVSVLLLDEPTSGLDAFAALNLVKNLKEITRERDLYTLMTIHQPSWNIFKHFDRVILLTRGQTYYSGPPTAAPAWFASLGHSPPEGVNPADFYITIAENYEKTNDAENRVRALLSSWRTGGDAFLASNADKLAEDDAQVSAPALGRTMSRIVPKSSDANEVAGSWPNSWWHELAVLTHRNAMLIVKDPTIVFASFGQNIVLLIIIGFAFFRLNLDQGGALARIGALFIVPVNASFAVLFPILAIFPLQRNIMLRERSAGTYRISSFYLGKIVTEVPNQLLQRILFYAVVYWMVGLRQTAGAFFIWLAINVLQVGTAIGLGLVIGCGASSIELANIFAPVINVVFLLFGGNLLPLSSIPPWFIWLHWLSPITYTYSALAQNEFRGLNFECSADSQQCYRSGQDVLNQYDLERFTIAENAGFLGAIAVVFLSIGYVLLRFLGRPSFRYVKPKTPLSDQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUN2</accession>
    <name>W3VUN2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00976</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUN2"/>
    <dbReference type="HOGENOM" id="CLU_014853_3_1_1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="197"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="420"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="850" mass="94770" checksum="A6A3A5DFF9BF8B53" modified="2014-03-19" version="1">MTAVGSAPGPSEPSALPPPSSSALPDAQDGVGLPFPDVAQLTSRSSIVQALAELSRHSSELDDELVSLFEESEPVVADARRSIASLTPQVQLVQEEAAVLDRRLQASASVAKRISERVRLLDEERKRIALAAEWARKVAELKSSLSLLAEAVEHRDWDMATMHCRRAMAIDPAIRSSSFAAAVVPTTNLPEPPETTLLELRKTMLTAFTDAFIRSTQNKDEKEASRFFKLLPQIGWKKEGLEVYSSFARSMVREKGRAISDSLLPGKAQHPTHFALLLTSLFEHLAMLIDMHQPVVDRHYGAGNFSHGVMPGLQDECDRLGHRIMDSWRQDRNVRRRLDEVQAYRSTSAAMDAKTHHSTFKASFGAPARTASPAAGSTANSSFDEPAGPDGREVDRILTELAAMSSRWGLYRRFLQGRLADDQESDKPDAERQSSLDDQRASQADEPLKDFRRSSVDRRGSVAGSLGDADTATETPPDSIDHAAESKLGQEVLETMKGSYMPLETWYLRSSLEKAFRIDQPDTTARPYTSSILDDAFYVIRTVLGRILSTASLSTLTDMVRVVKTTLEQEYIEVIVRKMETLWRSISGSMSVDGPRKDAASREMRTVFITYLNVLDVSSHYMSRVLAEVGNEQSLARLFEPKEMDEASAAVASLGQLVNRFRSSLRTEIEHMFTQLTAPRLRGILVETYRDVSYVLDDEGYSDAESRDLVRRRFVKSWELLLVHFRGTFSQANLDTYVGMALDALLKPWEAMVTGMRFTELGALKFDKDLRALIGFLTTQSSLPIRDRFTRLQQISYVLNLDASEHDADLYHNAVASGISWRLSMAEVKTVRALRISQTHPHRQTSLTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUY6</accession>
    <name>W3VUY6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Endo-polygalacturonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_01108</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin. Activity requires a galacturonic acid backbone substituted with xylose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUY6"/>
    <dbReference type="HOGENOM" id="CLU_011370_2_0_1"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF9">
        <property type="entry name" value="ENDO-XYLOGALACTURONAN HYDROLASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53577" checksum="74F33A5280603221" modified="2014-03-19" version="1">MDADRIPDGASVGHDFDILARVLGSNAGGWNRITSISTNVAGANVTRDEFNVHQVEIASLGVPSGSGVEFRIRYLARQVDSAAIRPASLGSRVTIEDGLIQFTIERAQDFMLEINEDKWQALHVLMNETSGAEPIGDNQVLWYFGTGVNNGEAFAQVTDGQLVVPSDTVVYLAEGAFLTAQVVFSGVANASLQGPGFIYRPGTAYTPSASQRPRELDGGAILIERSEKISVTGVTSLRSFGFSLPVIEGHKIHIDRFRSFSGYGNGDGIDLFCCKDVLVENCFLRNSDDTIAIYGHRWGYYGDTTNIKIRRCTLLPDIAHPIQIGTHGNSEKPERFSKIHVSDIDILDHEENQMWYQGCLSLNAGDENAIEGVIIENVRVEKITKGQLFNIRVMQNAMWTTAPGRGIRNIVLRNIQLDTSRSEKIYPSQIIGYDARRRIDNVTIENLKIDGQHIHDGMAKPKWYMVADYVPMFVNEHVGNLVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV85</accession>
    <name>W3VV85_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1909-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV85"/>
    <dbReference type="HOGENOM" id="CLU_181109_1_0_1"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8132" checksum="54C194AE7F76B157" modified="2014-03-19" version="1">MGNGAKAQQKRERNAKAAGGEAKSQKKVNEAAKNVMCMTCRQTFLLTVREPALQQHATDRHNKTLAECFPGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVG1</accession>
    <name>W3VVG1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cwf19-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVG1"/>
    <dbReference type="HOGENOM" id="CLU_015540_2_0_1"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="569"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="704"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="94791" checksum="7E6EC9392DA13412" modified="2014-03-19" version="1">MGESDDRREHRHSSRSERRNDDDRHRSSDRYRHRHHRSHGHSSRSHDGHSNRKRRRHDDERDHHRDERHRHRHRSDRDHHDRSRRDDAKDHMDSKQQDKQPAVDFIPTAESLQIVSQDDRSEDKAPSSGLKRDDWMMGSGGDDADEATFFSSLGKARVKAPRPEKPDPEKLKVSSRELNSQLREGKTVDEYATPSGSNTRAALGAPGYQWRMMKLKRTLEAAEQSARDLNEVALERYASLEEFEHAQAERRFLDNRPQAKDDDRSVRSTPTLQSVARRSYLLASGSTAEPERDSARNGTDSPAGGSRPASRQGFRRPGESSNPSTPTPTTRPPRTVGFETPTSKPTTPSAIPSVFTPVIERPPETQPGVVIQNASDSDRPVLSADELNKLQAKIVRAELMGDGDLDALRAEYERETARASTAPSPAVPIKAGVLTQDGERELQVLPTLDARGRMYDVGSLNHSPQGAGAKAKRRLRGRDEFEARDSKTGQIVRYGAEDDQVSLGDLVRAEKLGAGSRWDKEADAEMAANIMADAGFSADLEAQDDEAHRYAKKKMRADAVKRQFAIGDYARTQKALDRCRFCWQDEGAKPPRAVVVSSGYRAYLAVPEVEAITERAEDHVLIVPMQHHLSLLEADDDTWDELRNFQKCLIQLAASRGQRVVFFETLLSIKHQRHAVMEAVLLPSAAMDLLPGVFKQSLRQMGGEFSTNAKVIEFTPARSFRNALVPNLPYFAVAWDHRWATGYGHVIENLNPTATQADAYDVDEMAAGSNNAEFSDNFARDVIRATLEDLDADNEGGSPSAPYVRSFGKSKHRNHDEKLRTRETFRRGWNQFDWTKQIPNQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVH7</accession>
    <name>W3VVH7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVH7"/>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="90"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="529" mass="57803" checksum="7E687C265AE9AE4D" modified="2014-03-19" version="1">METSTLPTPRTSMSDTARASTSSRAASTTNEANNKSTTATDLEKGEAPQSKPSPSKEAAAESDADPNLVTWTDNDAENPLNWSRARKIMLLCVVTSCAFCVTNTSSIISNAYQGIQDEFHVSREVAILGLSLFVIGLGIGPMLLGPLSEFYGRRPVYLVSYTAFTLLGLPVSFANNLAVFLIFRFLTGFCGSAFLSVAGGSVSDIFAASDIFVPMAIYTNGPFLGPVFGPLLSGFINQNTNWRWTFWTINIWSTVMLVILVLFGPETYAPALLATRAKKLRKETGNAELYAEHERVVAQKSLPRTILTSSTRPFQLLAREAMLTLLCLWSALLLGILYLFFVAFPIVFEKHGFNLQEVGLSFIGIGIGMMIAVATMPLWARHYTRLVKNKGNGVAEPEFRLPVAMVGAVLLPIGMFWFAFTTYPSIHWIVPILGTVVFGVGISYIFTAVFTYTTHAYRPVAASAMAANSFSRSSFAAAFPLFAKQMYVGMTIQGASAFLAGLNVLMIPVPFVFYKYGKQIRARSQFTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVN1</accession>
    <name>W3VVN1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Far11/STRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003184_2_0_1"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="354"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="798"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1259"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1475"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1500"/>
            <end position="1515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1654" mass="179276" checksum="4144A40698495019" modified="2014-03-19" version="1">MSFLTPSFSEVAEAAWRRCIRRSVSSPDFVEIFARSSAERARSQRLWEGLDVISEGQRRPCGSADRSGLVVHLSPTVSLVRRLDQAPEPSILIIHPPSNPLNIPTRRRRTQSANLQDALNCRINLSSFTPSNTNPAHPSATHSAAGSASRGADAATSSSFPPPPSSSTSANAPLAASSSLIEDLVNTGQNPALRKVLFQLGSAQNSDLSAVTNSLSSSAPASSTPLSELAAASADPSRSDPSLHASEGSASTATQGSSLPPISSNSAANDSLSQPTPQRQPWQRPPSFEGGTSFRQHLERSQVQLQQPPTMSAPTSQPQPQAGMAPQSQNQGGPLDSVTLGQLRNLIVTDKPKSRQYDFPIDADADNMQNEIDEFYSYVEVPQTAENRTAWEEWCTMPTHLRHAGYSSTGSELGSAEPSSSLGLGLDLNHAGVAPHSTEGQSAGMPRRASLIEPALGEWTTLGSSTRRRILQSLLSTLEVRDPEARFRASRALLYLLQGAFADTAGPEHQLHWLLENARMVRSLGGLGEIYSAIKLASWKHDYLSSLPDHIPSHEPAHTGQQGPANAPLLTPEAKLEYLDEINLELALHFAQLYSLLESSRGEEEWGDELMSLDPPLPIFLFGLVASLREKSAKGYPVKKLLLLLWKSLLSCFGGVKDVERCKLLAREIEGLGPIDKSTKRNVLKSDPLDFQDFQHEISVKYPTFEPPKRQDHDLPLDKLASAIHPIPPRKPFSNHLDGSDRYPGGPQQGPNGMLPGTPAPSPPPSPKPNKAKYQTDQTRPFIFPYSRQVHGQGRLVPRSIDEASKLYTEHMHVSLELWQTWRVREQCIQEESGVGSAADGTRIGLGVKSAASKAYVRTDAASSSPGSRSPVSSEAFPPRGVSERTFKVKGEATYEHLVEIEEDIEAELRDVEGDHMLAALDNPRHTELIDHLAQKRADVRRLQRVDQLYRAVLPQLQSSVIVLLKLLLATVTSINTNSAHAAAIAEGAPIDEAPPPTLEDVDVARHREILTKAVSAILLLCLKWFKASHVMKFNYLSQVLVDSNVLLLILKIFGLQEIAHGVKTKNEADNFRFFNYCYLNGGREARGPRAEDSLMSRHNIIGPVAINPGTTSPPPGKATLMPDGTEVEMVSDYSWRNFFSSINFTRILQKLTKRKVHRILLLVQYKSSAILKRSLKVPHPGLELYVLKVIKSQIPFCGRKWRQSNMRVITSIYLNCRPDLRDEWLSGSDVEADVEDSLPQEQALRSLVKFYNHTRFGPPPGAALGHGEGHGHRRSISTSAERHQQEMQNGQQQGHAQPHMQSQFHAQQPQHQQGGQQHGAQADGGPHSQEAQQAQRGGMSNGDGANEHGAPPATLSPTRTANGPSFFESDVLPPLRRSHQASAPGGYIPDDVVEGYLDTYEDVLGEVFGENVFYPSDGGGEGGAAEEDGAGGEAGASGSGWSSGKWGLTQQGSSTAWARLGEILGETGITDADTASLDSAHSGAGSVAGSMTDDEGERDENRNDWEHMSPKEMRFLSSGVLSPPSPSPIPLHGGKQPSPLQSPRMSAAALGTSALDTSPGSPVRPFTISGVSSGGGSGSRPGSRRNSRSNSDSSPLRPVLTDWADDEQLDQIDRLAQAEARGDDEQDVDTAQPLPLHHRKAGGIDEVEHIFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW53</accession>
    <name>W3VW53_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW53"/>
    <dbReference type="HOGENOM" id="CLU_571306_0_0_1"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="100"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="525" mass="54956" checksum="F0A5B8A0823247BB" modified="2014-03-19" version="1">MPAASTARKSTPTRKSTPRRARSSSVASNASTAPPASPSASPRKTKKDKEAAAAAKAAKEVKETKEAKSDIARPKLPTKKNPRLKEVDEAVVKLQTIKREGHNIIIGRVKLPTVNGQDHAFLLKRFDTNAMAASSMFRLAFPFADGNAEAAEMQFLDAKYDTNRANGGYILEDVKAPETPKKRGRPRKNPETPKKDAATDSESVAGEKQIRVLPEGSTGVRLQGTWIPAEDAADVAEDYGIAKFALALIHATAEHSEDGGPPVLTSAPTTEVKTPRKRQRTSTAASAASDAESPRLVQKVTRVENADGTISQVNVETTIEGSTNGIPAALSQAEIEAQIAEAKALAAGIQKQAGAAGKGASRGQKRRAVNDRPTAELDLMADDDDYAESGRVVRAFKRGTRVARKRPIATTAGALAAAGAVGAGALAWISGGNPDLALQTLQTSLQNLGLQNLQQFGGQLGGQLASMLPCAQLPSDAQASPHRPNPGAIARHGSLALNSASASSVPCLTPISGTAAPPPLQHMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWP4</accession>
    <name>W3VWP4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_00263</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWP4"/>
    <dbReference type="HOGENOM" id="CLU_150783_2_0_1"/>
    <dbReference type="OrthoDB" id="3063237at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS65196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11195" checksum="EF349870FCAD9DD7" modified="2014-03-19" version="1">MSTSADRTYEQQNDSALDALYSKVSSLRSVTIDIHNDSESQRAGLLAQTSDQFDSFSNQLTRTSNHFSRSIVNGARQHRLTLYIVGGFVGLWLLYKLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX88</accession>
    <name>W3VX88_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX88"/>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="141"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="393" mass="42318" checksum="9342211C6C507FCD" modified="2014-03-19" version="1">MDGAREGGWRAAAARFGQPLENSSPSRLVSPLSGSSREQQLSSTTRDHPSQPQWTSPPDHSTMNRGPSGPQNIFRALERLRQQAQQASQQFNNAGKPGGSSGGSGGSGGGGRGGPPNLANILGGSAGIVALVALGFGINMSLFNVDGGHRAIKYSRLSGIKENIFNEGTHFMIPWFEKPIDYDVRAKPRSIASLTGTKDLQMVSLTCRVLSRPRVDALPTIFRELGTDYDERVLPSIVNEVLKSVVAQFNASQLITQREMVSRLVRDNLTARAQRFNLVLDDVSITHVSFSPEFTHAVEAKQIAQQAALRAAFLVDQAIQEKASIIVKAQGEAKSAELIGEAVKKNKGFLKLRKLEAARDIATILSQAGAHNKVLLDADTLLLNVANEDPTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD10</accession>
    <name>W3VD10_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_06447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD10"/>
    <dbReference type="HOGENOM" id="CLU_022549_1_1_1"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS59528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60852" checksum="A4EAAAE2DD3C66D6" modified="2014-03-19" version="1">MSDDKRDLERRTTHIVVPYTDDEEASSSATTTLLPQPQASTSTSKARRRCWRLAVLVGAMLAMCIGVFELLFHGREVESLRAAHEQIAQLKHDLSEQIQGGYYKIMAATYLRPSTTSDVDPKLKAVMEKSVIVLKTGSSVAYDRLPVQLLLAQQALHPEVYRSGEDGYKGPQLLLYSDAELHLGEFEVHNALANVSDYVRKQPDFARQYAQLQKLLQDDDLARVKEFQDGWNLDKWKFLYMWQDAYHRQPEAEWYIGYEADTYVLWPSLFAYLGTQNSSQQQMYGCASILVRNQELFANGGCPYVISSALMRATFGKDTDFAAKFDKEVEASCCGDAELSIALRKSASPPIQELAPTGGRFVNDRPQEITFDENNFCEPVFNFHHLTPTEIQWLANMERQIRTAKPNAPVLSADIFDHVLPHKLLDAVSAAGTKSKKGVELNPMLEDWEAFGSGDNGVKKGKRSKDVEQCKAECVASEGCTTWFWIKVTETDEDGDCYMLHDRVRVGKAYKGTGVRTSGWIGERVLDFKNKHECKNPPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD51</accession>
    <name>W3VD51_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_06495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD51"/>
    <dbReference type="HOGENOM" id="CLU_043433_0_0_1"/>
    <dbReference type="OrthoDB" id="2547444at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS59573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="498" mass="56535" checksum="34DF9AFAAD165696" modified="2014-03-19" version="1">MSYGHWRHPVDWPVCSSDLLASTWRRLPRELSLLIVESTCWLVPAPTLYNWCLVDRAWYRRAVVSLYSCVSLSPHDADERGALRIQSFCDTISNNRWLANTVRALDFAISREEVGLANQEQYLAILTHCHNLLYLRNLQRHRDPDDTYLLSVPPGALARLRWHDSDLRAFEELVESVFKPLHFRANPDARGIERSDLIATDARSAGRMLYDLRMLARLPSVHKLPKGFFRRMVINQLPRQKILSARCSKNYQNDRIGTRIAIGVVGMVSRLLPQVELVEVYVADRDFHTGAPLHFISKASSTGLPCLYPRSFWDDTIQHLVDLAPLPFAVAVYHVCSNEVGDAPGFDIGGEYDLSPAEQAPSSDIEALGNEYPYTVQEDDVSCRSTTGHGWQEPFLLLPNSKRMMPIKLKGGYRTLPFTSYDVDGRKAWEVLVDPPAHIAPDDAHAVNVKEEWDVESMLGASRPRPSLMHPLTPRRGSLDWLRLVARNLEFGQHDLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDB7</accession>
    <name>W3VDB7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDB7"/>
    <dbReference type="HOGENOM" id="CLU_705958_0_0_1"/>
    <dbReference type="OrthoDB" id="3358664at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="391" mass="41767" checksum="5584FDF81B462204" modified="2014-03-19" version="1">MSASALATPVPPPLPVTRSAQPPPTHVEFLLSQVRANLRYLSEIGAFDTGAYRQIHDLLTRGTLDPHAVSPSTHPPPPRPTERSESADELGSKSAWLRKVLAESSVLPTTIETALSLTAGPLLSDEQKEAIVQLVEYSQQGVANKITDPTLQKRMGSGARAAQSSTARKVSSWSRGLKQDRQKKKSQSEEKKDGKRREKEERRQIKAELKQERNEVIRMRQQQMLGDNASQASGTIASPVFTSRAPAGIEDDSSSQSSSEDEAHLANRGPINSCDFATGASAIADTATLTVLSQPIKGSETSVGGTNTTFVVEPGLAVSCSLVVIKGSQVQDQLERVREAAAAPQVPVPAGTASHATMPPPSHPDVLAVRRHSGTTSQPPVPPRPSTQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDD4</accession>
    <name>W3VDD4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromate ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_06459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDD4"/>
    <dbReference type="HOGENOM" id="CLU_018106_0_2_1"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS59540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="87508" checksum="32B2793BF7B38EFD" modified="2014-03-19" version="1">MGSSSKLWNSPSSEIAALEQSALTHAPIDRSSFGRTEPCNPAGETRSAAALPHTVWTLSTVSVGPQQSAKLKRGIEIEARLQVNSDRTWRRVEMRIGTGAAICVMLLSLKTYRHDLGFYICFKPLNVLGSDLTFTKYCANMKLHPAPGLLPGPPRVAATARQRILGRFLHRARHASFSATTGRSSQDDASAGASILLTIIRSTRRVACITAMSSTQVITRSRSRVSDSAPSPGPSALNTPTAPTASASGAASLDDADYDDRRNLKLSVRLVDTIRHYWDLGFTAFGGPGVHVVILRKRFVDKLAWLDETTFADLFSLGNALPGPGSTQLAFSIAVARNGTLAGLIAFLFWSLPGAAGMAALGAGVRKFPERLPPIVLGLLTGLNAAAVGLIALAAFQLSKSSITDPVSRLLVLGSASFGICYHAPWMYPILVFGGGLITLLYDFRHTIVKATIGKVIRRSSRSASNGAVAHDPAQSGHSDDIELEPVRSQARTSLEADADKHQSGADVQELAFQNGTTAAPASSIRQRNASTVERTHSSSANRSASASDAPLTDRRTPIMVLNRTIALALGAAFIVLIVAVVVTRSQLSSPPRALDFFTNMMIAGVIIFGGGPVVIPLLRGYTVENGWVDSRDFLLGFAILQAFPGPNFNFAAYLGVLSLPSNPALGAILGWLGIFSPGLLLKLSLLPLYNTWRKHEVAKSVLRGLNASATGLVYTAVWQLFLGKQAPTSLVRIRIVLTKWFVFCAVGYIYTPARGPVVEAASQSGPLTSDPFWGVVASSAFVATQWFKSPPAVTIVAGAVAGLAWYGVVGPLGTERQQAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDY1</accession>
    <name>W3VDY1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_06261</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDY1"/>
    <dbReference type="HOGENOM" id="CLU_006615_0_0_1"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000112">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="350"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="434"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="532"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="747"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="898"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="747"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS59739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1279" mass="137077" checksum="EF76A84C8DEC8D7E" modified="2014-03-19" version="1">MALPPFRPSTRQPVRLDAPISEGERESKRERQRPCIPTSSLPLILPILLSSTLGSPEPYRGRIRSSMSSPSAFALAEQQEHIIAPDDSDFLDSDAEGTPHPDDHLIESAVLQDVPGAASSSSSPARRARSAKGKLWPAHPLIRIHKRLWFTWFDASLPNEDELNLDAGHGAAWTNFDDGEVSKYVDAAETKPARLHWFNIDHDLVYLSFWFDWGPLNVGMFYRFCLHVHHMLTDPDMQDATLVLYTTHAPAQKANAALLATLYAMIIGKVSPADAFYPISELEFKPFRDAGYGRADYNLSIQDVLYGVQRAINHGLLDLTTFNLDEYEKYEQVHNGDWNWITPNFIAFASPNDRTYVEALRTGDGRLPSNYSFRPPGEDKLFGRTIRYFKERGVQLVVRLNNPLYDRDAFVHAGIQHADMYFDDGSNPTDDILADFIARADEVIRNDGVVAVHCKAGLGRTGVLIGAYLVWKHGFSAGEAIGFMRFMRPGCVVGPQQHFMYQNFVEWVKWGVRDQALADARKMLAEEKARLEAQYKPSTPPSTTRAVKRRAAGSDAAKVAGDESVADEHEGSDTDAEEHDEAARPRQKHKREADEAPVTPRAQRGGSRAVPASAAPGVKPAPCVGQPRKSPSPSRKRPAIQAPATVARLELNTRRYPTGASSFSQHLLRATNAVHVDADSDAEENASLDACAAGGSTAGVLVEARINVATPLRASPKAAVGTPSPVARVRGFERPRASTVGSIATPIRTSSRSASPASPGRDVVRASPGIRDRYGLRDSKSPPPATPPTLRTSRHASPVKIAPLVARVTDAEVLGVLACIPQTDRASPPKPAPKPVAAVADENAIRAPVTAPKVLRTVRSKPTLTASAAPGVRRGVVAGARSVSAKTAAAPVVRTVRAQKSTADLRTAAPASRSVSSSSTSSTAATVSRGGSRLTAPTAASAARAAAAAAQRAKVAPPAAAAAGGVRKVSVLRPQPVRRRRSSTGQADVDLHPPTFSDLSLFSPLPRHPPKMSRLSNRVCIVTGGMRGFGASIVSLFASHGARILVLDLLTPSAGYYTPSPDATSLTPSSATTNIYAVAADITSRDSWVSALATVKELWGAVPDVVVNNAGWTYSNKPTLDVTDADFDRVFAINVKSVFLSTDVVLPAMLEAQLDDAVFVNVSSTAAIRPRPKLVWYNASKGAVSTATKALAVEYAPHKVRFNTVSPVAGNTPLLSKFAGSAEAGDTMSPHQLAQFHASIPIGRLSEGSDIANACLFLADAASNFITGIDIPVDGGRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE86</accession>
    <name>W3VE86_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_06348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VE86"/>
    <dbReference type="HOGENOM" id="CLU_001839_0_0_1"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="147"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="647"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="805"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="875"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="966"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="810"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="308"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="333"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="427"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS59820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1025" mass="109708" checksum="C693D14051DA779C" modified="2014-03-19" version="1">MQSPSTSALLVPLPQPKIEQLQGVWFQRKGDPTCHKASLRLTSHHLIFQLGPALAPDQPARTHTVPLSLILKATRIPSLRISTQASQPSQRIYPITLFLKNFDSAAIALHSEHDQLAVFDSLKECAILTDVSQLYAFHYQPSSPTQPGRIYDPKQEFARQGLGSRSKAWRFTDINAQYAFCATYPALMAVPSRISDTTLSYAAKYRSKARVPALTYLHWANHASITRSSQPMVGLKNARSIQDEKLIEAIFTSHHFADPESITAKAAADASSSATSAAAGAPAVATVYGATTTNLIIDARPTTNAMANVAKGAGTENMEYYKGCKKSYLGIENIHVMRDSLNKLTDALRESEPIATFGMRVEALGDASAADAVSDGSGSVLRLNPTPVDPLALRRSMWLKHIQSLMEGSMSIVRNVHINSSHVLIHCSDGWDRTSQLAAIAQICLDPYFRTFDGLAVLIEKDWLSFGHKFTDRGGLKGSDRYFTVASKQTYANSNDADADDDDTDSELDKPASASTGGGGGFDSQAAANAFWGFTKQLTANFSAATSSAASGHKKGSNIKETSPVFHQFLDCMWQIMRQFPDRFEFASSYLVELLQAVQECKFGTFLMDCERERLSPRDDEGRVLPTLPSRTISAWTYLLSDKVKSKHRNPRYQPELDDRDPKRKGTDMGVLIADSRDVRYFEQLFRRANGDMNAALEKEAEERRRARERLERAVRGTDAATSPPPDTANAQGSDAGNSAEPVPVPVPGAGELEKADATIAVVGAGDRDPVLDPLASAAGVAAGAVDPSSHAPLDHSRLSYQARQPRVRAQPGAAATSSSSSGPSAAANAGPLDSSAATAANVSSAADAAANRMKNLLIGGWGRLQEAMASPAIAPSETTPAPYQAGGHSEGGYSASPGSAQPTTDRHEAPTASAQSYNADPLQQSYKQRMPGSAAHTVHNPWAAATSVRAEMQREHVAMRSTLSGAGAHGLGAPHRSQGAGANQPSRHDQAPNGRDGVHESSGSESKTDVKTSAGITSDPLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEB8</accession>
    <name>W3VEB8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEB8"/>
    <dbReference type="HOGENOM" id="CLU_037784_0_0_1"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="514" mass="58503" checksum="9B0369FD05740D2D" modified="2014-03-19" version="1">MVKLCAAALPARLPQAQHRCTVPARWDALTIITYASLTMSTWQDVQKLPLLPLQHDQVASHLNRVQDAGLPHPTHPLSKLARTSASWTRHLNTLAERSSTGLVPWLIVLPLLASVLAHVYFHMFSTLHIYLALVWLGVPAATVSTLAAIASRSATKSASGRDRLKATVLLTLLCTVIRRTFTVNPRQAFSNDPYEQSQNQTFFIAVDMYNSEHLFPSFSQSLLTLAERLGKSNVFVSIYESNSKDSTKQHLLRLQSEFGLRGISNQIRMIDNSRREELDRIQRLAMVRNEALRPIHDGIDALNNQTFSKLIWLNDILFRPESVLELLSTNGGTFDQVCALDYLPLGFYDTWVMRDVEGDRPTPLWPYFKREKDVNSLRRGDTIPVNSCWNGMTIFDAKWFLPSNDSATGTPGVDDGPIRFRTHPECNVSECLLPSYDIHVRSKSRPLIFVNPRAVATYQYRDFLMYDRIMRSNIVTLWSRVWQDLISHSLFGFMVEIGRKKDECADTLRKGWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEE5</accession>
    <name>W3VEE5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_06004</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEE5"/>
    <dbReference type="HOGENOM" id="CLU_456432_0_0_1"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15587">
        <property type="entry name" value="PHD_Yng1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="526"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="424"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="598" mass="65654" checksum="FCEC97B493C11CDD" modified="2014-03-19" version="1">MRSSSSSSRIASDAHYHEAATGTTCRNLGRQATNSHWMSAPSSPRKGSVHSSPVRAPRRRPSATASSPSSRTADRRARSAQLYDSIGEMDDENDAAYDQDLDADGEYDDDYLDHDAQGQEEEVVVATVPPAPTRSGRERRTSENPTDSTPRQSSRPKRSRAPHGSYYDLPPLPSFSDAEDDDSEDEAPSIRKRPRRAEVLTSDAESEQSSHRRSDAPGATNSKVAEDEGQSAQPPVELSEEEKQKAREDKEQHELAARWTDEYFEIVEQLPLEVHRAFALMRELEGQMHTRVTGMVHDIATYHHARLAHPSTTSSSTSRSQKAGSEDEAERLLGAPLPCPDDGDAGMMDKAERMDLLRGISSAANESVKAAEEKMGLAATAYEWIDRHIRRLDGDIAKLEASILLGLRSGTQESRGAREALGLALDDPTPAPAEPAVSVAESAALTKAAGARRGRTRSRSNTTTPKQRTTSLPSPSPQPAVPGQPTRKQGGRRKPRPSTGRRKSTLADPVVVRPDVSDMPDDPTEPRYCYCDQISFDQMVACDNDDCTIEWFHYACVGLDQQPKAEWFCRFCAPPNWKGPGMLVPPNAKHLPPPPNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEQ9</accession>
    <name>W3VEQ9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEQ9"/>
    <dbReference type="HOGENOM" id="CLU_918669_0_0_1"/>
    <dbReference type="OrthoDB" id="2555860at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="303" mass="31340" checksum="BEEF63B98940BACC" modified="2014-03-19" version="1">MSTTPSPSKRARLPTSNIPSATASPFAGSSAARFTGPRSVGPTGTSAVGMGMSPSDAFTPGDGYGMSGLTPFSTTSPAYAAGAAGSPLSTALAHGSRVLSGIQAGSPFQNQYTAGPTPMIPQMQYSRYPSQQGVPWNAQYAYPVIMQQPVPAAKPQAPQYGSPEYLKMSLHHLTAVLLPKLEAEEQAYFDAVDASLAVTADTRTVAQKAAAFQAALDAVLTYLDEKGLASIPLLPPASSTDPDPASSSDAPTDAPSEPTASSDPNPDTLALQLTTLQQHAKDLFSRRQRLKDSASIVTGILDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF75</accession>
    <name>W3VF75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF75"/>
    <dbReference type="HOGENOM" id="CLU_032666_0_0_1"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="279"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="553" mass="61929" checksum="105BFE6B09E3926E" modified="2014-03-19" version="1">MSTRTAIRSSRGLQARRIGTSTRVLRSQPDLTGADKLLDDARRLEDEERRALAKKTQGPDPNDPAWTGEERVQDTVLRMVMDKYKPLRIRGDESKDPADEKIRQGIQQPSAPGPASIERQAVQPQDPASSILGVEAEGGYEGGRKLPKTPDAKPWRAVYVRPAHLGNATHEPSVYYGQFLKSSSSPIDTGMSSEMRSKLRAAGMAASMRTDDSKAMTQLRQGLKSAERRGKLVRARESVLDYQLSKPSPSSSEGVGDEVSDVTRDLQLQLGHAQGWDSVVEKRIKAAQEAGVFRHNKLRGRPIERDMDEKNPFLAREEYFMNRIVKRQGAAPPWVELNTELDAQLQSWRARCADSWVRRASRMITTSHLASGLEPLHPEAEARTRGEKALVELATRYRDAEWEARERAYHTHELDRLNDLIRRHNHLAPFTARKGLMNLDVELAGMYARAVPRLVREVSQLLQQHHALPEHTLDRALDRAEPVTYDMWGRPVRATDSTPGIFDAWWGSATADRKDSPTNANAAGDTTPHQMPSLGIVAAIQRSLQWARTRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFG1</accession>
    <name>W3VFG1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFG1"/>
    <dbReference type="HOGENOM" id="CLU_011969_0_0_1"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="297"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="480"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="941"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="946"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1002" mass="107266" checksum="6A5F4E181395F965" modified="2014-03-19" version="1">MSLLVANMPSPPHRDRIDPEPESPGTSGFNTPTASSGHHTPAAGYRTAAGTISNAFASLWGTYNQQQANESGPSRLRPDSSSQSPNASPNMSVPGGWGNLLSWGPAAARQKSNNSTQTLRKSASPTRTGRAKSGRSRAAIPFDISAPVEATSVEKHDTNHTHTSDNGTSDHHSLGQTGTMPSPRRSPTSSPRRRPLAGIFEDVPSSSPPHTPASHSPTSPRARLVHDLPPHSPSLKHESPSGAYATLSRLQSKSSSTKLRSGSGFLWPSATPASSKSPNSPIPHQRPAANWSEAIARTEKLDSYVRRIVFQAGLDYETRPMVVLAACCLPDPKEVDYDALLDRIMDTMDLFVENDYTVVYFAGGGHHRPGWNWIWRAYRRLDRRFRKNLKKLYIVHPTFFTRSLLQFVNTGAYFVSPKFSKKVSQLYTLSALAEHVPLTQIDIPPEVLQWNAKYESHVNLPSKTSDALAGQEATDRVFGVDLVRLMGEYGESGGVPRVVRDCVDAILGDFNSIRPAEVEGIFRRSPSSALLKTAQESYDRGHPVSLEQYRDPHIPAVLLKVFLRSLPRPIFAASMYPLIRACPPPPLPNAQVPSAVHEAQAQETIEYLRTRLLPAIEPSCSGILLSYVLEMLHKVAQHREANKMDAANLATVIAPNLVSSGNAIKDVMICRVEGMASMTLSAQPPASRSPQLRKASLSSNADTNTTTLGSIVRFCIERYYEIFDEVNFGAQSNSVQELVDDLGKDDGSRSPSMASRRLPSVYDTPMSQHGALGLDARMHRRGGSTQSSVSGVSVSQPPSPWGMTGASSWHGGAADEDDDDRRSGATGRSITSRDGYRAPAGVHRGTIARNSSGSLRLTKGRLGSNTNLRGSFTPANASGLARPSGLTPVSAPAAQADTDTDALTSQLSGVALTGANAVATFSSPVAERTSVALGGAQPLVVGGGKALTPTSGSSSASASPVLASSPHWGVARGGGGDQPPPSPAARRRERTELSQVDEHDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFJ6</accession>
    <name>W3VFJ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFJ6"/>
    <dbReference type="HOGENOM" id="CLU_801988_0_0_1"/>
    <dbReference type="OrthoDB" id="2556831at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="36747" checksum="6FE3C7AC354EFCDD" modified="2014-03-19" version="1">MEDLMNSYRDDESEGFDIEDLVNLAYSSDHSSDEEPPMATCPTAPPSREDSDESDESDNDASSNEDDEVPPAQAADFPVEIDTDSEVEKVLLPPSTQRPAATPIETTPGPATLLVETPKEAVRGTSTRGRGGGRGRGRGRGGSTPPCTPRNERPSSSFSSPSSAGTSSGGTRTSTPASSPGSLPTKSSPSSPSPESRPTKRKRTLSQLSVPSPSEVATNMGESIVQAIAATATPVPQEKTHKRKPKPAPPATESAQSEAPESEAAQQPVPATGSTSSPKTTSPKKASRAKPTKKTGHWTREEMMLLFHEVFPRKYDLAWDVVSRAAKVPALISELEDFLIDKHPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG34</accession>
    <name>W3VG34_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG34"/>
    <dbReference type="HOGENOM" id="CLU_2741114_0_0_1"/>
    <dbReference type="OrthoDB" id="3358841at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="66" mass="7229" checksum="A10C463A3A62B001" modified="2014-03-19" version="1">MEKTFNDTLPTGAQRDQDNQQRAQQGKPQIPHAAGREQVASKDPKEYDVRGGPGSEGNKPVQEPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG47</accession>
    <name>W3VG47_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG47"/>
    <dbReference type="HOGENOM" id="CLU_043736_1_0_1"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="375" mass="40690" checksum="90CFBA47D2F5C644" modified="2014-03-19" version="1">MTADIARSQQNAFAQPFALSARYAADRGDAPKGEDDFVPDLNVRLICRDCKTDPPNLAEEFDSGDLVCADCGLVVGENIIDTRSEWRTFANEDGDDPSRVGAASNPLLDGINEQLESRIGYRDGGSGASRDLQRTMNRATGTRDRNMLDAFEDIQRKCDSIHLPRTVSDVAKQAYRRVEEEKILRGKKPDAIIAAAIYVACKMNHVPRTFPEICSLTSVSKKHIGQCFKEMQQAFGLNATGTGSVDGSRASANNSGTSTPIGIGPTGAADLVGRYCNHLGLEMRVTRSTEDITARVRELGVLAGRSPITIAAACIYFSTLLWGVDKGAKRISQAAGVSDVTIKNSFKELLKHKDTIATPELLAKHPQMDISRLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH94</accession>
    <name>W3VH94_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04865</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH94"/>
    <dbReference type="HOGENOM" id="CLU_029210_0_1_1"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="359"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="629"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="675" mass="75211" checksum="287CA0019F5EE7DB" modified="2014-03-19" version="1">MVADPSQQGQSTGAAFQPQQQQQQQQQRQFFGGEEELGDEEELGDDVDLVVGDYSSGAFAGEAGAEVDEAQAAALAAANAQAQQQAQAAALAAVPDQIRKYIVLFNQAVQNNNVQDISNAYEGTWNRLTDKFYARSEWPEAETIAPLVNDDQKFLTLYRELWYRHVYSRLSPDGEDRFHSYDNYCDFFNFVLNSDGPVQLELPAQWLWDIIDEFIYQFQSFSQWRNRASNKTDDEIALLQDGGVWSSYSVLNVLYSLIQKSRITEQLVAASKGEDPDEVAGEFGSKPLYRMLGYFSIIGLLRVHVLLGDYTLALKMLDHIELNKKSGLINRVTACHVTAYYYVGFAYLMLRRYPDCIKSFTHILVFIMRLRQYHTRSYQYDQINKTADRMYALLTMACALSPTRLDENIQTQMREKYGDQFNKMTKGGAEGVAAFEELFLYACPKFITGNAPPYHDEEALAEYKDKTVFPDPTQHQLRVFLSDVKTQLSNANVRSFLRLYTTLGTDKLASFLEIDEEELVEMMMVMKNSTRSLKWSSGSLLEGEVVNTSDLDFVIDTNMVHIAESRVGRRYGDWFLRNGTRMHDVLGNIQSKPLPIVSKEVRDEAAAAAAAAAAAGAEGKGDRRGQKSGWAGAAGKPGAFAGNRNAGRGPAPAAGAPTKPAGAWGASNPKSSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHE2</accession>
    <name>W3VHE2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_05020</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHE2"/>
    <dbReference type="HOGENOM" id="CLU_026434_5_0_1"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS61078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="577" mass="64829" checksum="4B3170485532ED79" modified="2014-03-19" version="1">MTDQAQEAYDRLSKNLSFDSHGVTETVDVPHAVPASQSSASVKAEPVLPAQPALSAKIAVPEPVPAANGSSLKLGNGSAPAVKDEKDASVKLAPGGKVKLTNYPSIANAPLPAEGNGTFSNLHLALLIFFTPAVVLRLIPFVNPQWFGWFSYLLLCALFGAPVAIAYWTVMSTYGPRINEKVQLPGKPLEYYMDIKDPALRKKYHSDKKIPYQTFHDAYFAGKIEPKLPLNELLEYRWDWCSMQFTWPLFEYVLFNLIPDVLMHTAKQDQTQIQDNYDRGDDFYAWFLGPQMIYTSGIISDANKAETLEELQDNKLNLVCSKLDLQKEDRVLDIGCGWGTFATFAAVNYGCDVTGVTLAKTQTRFGNDRLQKNGIDPSQARILNLDYRDIPVQPGHYTKIISLEMAEHVGIRHYDKFLSDVYNLLDDDGVFVFQVAGLRPRWQFHDLNWGLFMNKYVFPGADASCSLGWVVSHLEKAGFEIRSVDVAGVHYSATILRWAQNWESNKDKVVAKYGDHMYRMWSFFLWSSVIVAREGGSSVFQFVLHKNLNAYHRINGVKSHGGLLPRPSVTKFKSVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHY2</accession>
    <name>W3VHY2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_05614</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHY2"/>
    <dbReference type="HOGENOM" id="CLU_066931_0_0_1"/>
    <dbReference type="OrthoDB" id="4506189at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS60407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37753" checksum="1788142A1676B82B" modified="2014-03-19" version="1">MSLTDVPMSASARQHFQQYLSQLPTSSSGAGSSKTAPSDPDELLRQATILNRRTDELHARLAEHESAGTDDPQLFWTTVSLLSNLRDVSVQLGRANSDRRTADALARTRQNVAIAESMLSVLSVSGTTQASGPFTAPLQPTLAVETPGQAPSHTERKGYESWRQEALAGIDDDASTTSTLGYEESDAESVLTDPEIHAAPSKPAVALGGIRREEDDDDLSEYDRGLKSRGEASAAATTATTGTNGTAGAPGASETILQSDRATHEALSSELLRMASVLKTNSLAFADALERDRVLLEKAGTDLGQNLDLMTRTRGRLGVYSKKARSMGWFTLSAILVVMVSWMLMFLLIRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIE0</accession>
    <name>W3VIE0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein BZZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_05261</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BZZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIE0"/>
    <dbReference type="HOGENOM" id="CLU_015390_1_0_1"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="13">
        <location>
            <begin position="6"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="406"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="495"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="580"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="640" mass="69978" checksum="2AB5C282864EDDDE" modified="2014-03-19" version="1">MSASAIDFGHELPDQLPTIAAALSAQLALESDLASFLSERAALERDYAAKLQSLVRKYREKKAKRDQDISVGPSPTIEWKHAHSTLSTHIADLYATHDATAADSNTLATGFDAVAGSMTASTKARDELRKKHIAYANKLLSDREKTYADKDKAKAKYDELCHELDSHRQKREKAEAGDKHADRAAKAFQAAEVDMLSAKNNYLIHIAVSNTAKQRFYRTDLPAIQNSLQSLWTFSTQRFVAASVKAQSTVAAHHELVATKHRHLESNASHVEPLQDQTLFAQHNQQRWQEPAGWSFEPCVGFFDTPEMSTEPAAVTVLQNRLLRCRDRIAELEPLAETKAKEVDGLHKLRDAYQDKPELGNPDEVMDQLFDSTRALFGFQIELHNLEAEVETIVASIGQNQGEARPHRFKPASFGIPTACHFCGGTIWGLAKQGAVCKPCGYTVHQKCEIKVPAECKAAPASEAPRVSASLSRSNRSSAILSPARPVATPARAEAQRPMGSVLYAFEASSPFELSVTEGEQVELLEDDVDATGWIKVRAGAAREGLVPTTYCEFGAQDETGDARSAQDAGHSVQMGAAQGCGQFVKAVFDYTAQGADEHSLTTGEQIEITTTGFSYADGWCEGVKDGRTGIFPSNYVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIR6</accession>
    <name>W3VIR6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000032">
        <property type="protein sequence ID" value="ETS60636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIR6"/>
    <dbReference type="HOGENOM" id="CLU_831890_0_0_1"/>
    <dbReference type="OrthoDB" id="2556251at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="133"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="334" mass="37354" checksum="E3D95D4801CC8AD6" modified="2014-03-19" version="1">MAHLSFELPARSNSLLRDWVVNAYGTPNFENGLTIIKWAESKRDKVTGVFVPEPPFEHNGLDRIFTNRPQFRHAIAELLGNRDVLNIFGANFLLRDPDKSLLDFLDAAFKPAVREYDRTHEPLMAVVTTPGAVDGGLKDCLPKEPSFNMFRRIRCLSPHVSFSTASDVFVNTSGTFSPMHIDIGMTSGFSTMIDGAKLFVLYGCNDHNRRIMQRCHLHPVDWSGALRLMRELTEPRLVYLKPGDTIYVGAGQPHFVLSPKPGALVTLNCANPSISEWDNTLKGYDSLITGICNYLSVQGLSQLEVGGRCLRQEAGGRTHEGPRDLQAAWWHKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ14</accession>
    <name>W3VJ14_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ14"/>
    <dbReference type="HOGENOM" id="CLU_088028_0_0_1"/>
    <dbReference type="OrthoDB" id="2556816at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="238" mass="24342" checksum="CD2B1A72F168F1D9" modified="2014-03-19" version="1">MHAARPASCSNTRRVALSLGGAAQGERESERAYHRERVREEPAAATEEVAAKEASPKKEKRQSFIGKLIGAFKEKTAKKEKPAATKEEPVVEEAAATDAAAPATEETPAAAEPTTEAAVEAPAAVEEAAVPAATEEAAKDVKIDESAKADAPAPDVAAQKIKLGRRLSGKFGALFAKAAPKKSEEKPAAAEDKAAEEAASPIEEKVAEDVTAAPEPVAVIAAPAVKAPESAAPVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ31</accession>
    <name>W3VJ31_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ31"/>
    <dbReference type="HOGENOM" id="CLU_009649_0_0_1"/>
    <dbReference type="OrthoDB" id="2555580at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1101" mass="115641" checksum="B1AA84568B6EB859" modified="2014-03-19" version="1">MSLRFLTRRRDRDRSNSILNSQPSPSGACIALPDQASRLGNASNAGNAGNAGNARNAAVPADVHIIVPADVHIISWDPRDLEAAGRDVHIRSRDPLPSPGLGPIDTPVYRAFTASQRLDHPPPVPAKSNPIRPQHAKSRARPKTASSVQDRQRIDFLESRPSLSAADDIRTDYLEVLQPSSTTATILSTQHDHAHTSNHSFSRRFASKIRRARSRSQQYGLAYDSGAETDADISHATLPASFASGSRIPYSHAQHNASVQSFASQASAHDREFCLLSPSNASSSFFSRLPNTRKLRRRQNASAADIQLLASSSAGTQPANDASAATSRSRSASLSTMAPKFLRPKDSRTDMVANAPPTPAKARLHRGAPPSAWRPDAAAAAAEAAAPGGSSTYSSDNDASAGSSTGHAHSLGATTSVGAASPGPYHAHLVSHPDAQHAHAQQLLGTSAHRPRTPVNRLSAITSALLPRTPDPESSPRPQSRHNVPSSPIIAGLPLSAKPARTASPAATNSLLASQLFKRLGPPPVGLEPHRFDERVLMIQHYIQHQVPLVPLAKPHDPVSIPPASNRSSLPPPARSSSATADARLAALADEFDKLECQTEHAMLELAAHKGDGVRVEIAELRLAHAFLAARRRCGVDSSRSHFELEAPPPAANSASPDLVSDPRFHADATPLRGTLGGMHPAPAVRPPSAREATDGLGGLGVSLRPAPRRRRRPITAPETQNKAIASMPLSSTRPSTARSSRSPAPASDTAGAALEGELFTPASFSARAGAGAAVVDADELRLRQMHAHAQARLVASRTVFAAPAHAYRRGSSDRDSSSSHNTATTHGSVRSPLFGAPAFQMVGWAGVGERQRTHSQDTADTEHTDASDMHAAIKAAVAREGALPAVSKDLSRKATTVSKLGRDKAQTGKANRHRKALPRKAQAPRAQSLPNPTAVGQGAASQGNSLAVSHSRGRTRRSPSKAQYGGATGGSPAYGQGAGEQVAVEQGYTRAGLQSATIVVMQSTVKQGTVEPGNRRPTRRNVGGEASSHCSSLQSDSPSARQGTVLDGSVSNVAGTTASVIPSRTRHGQHSAQPSPSPSDSIARGRIAAQSWLESTRSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ41</accession>
    <name>W3VJ41_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ41"/>
    <dbReference type="HOGENOM" id="CLU_011027_2_0_1"/>
    <dbReference type="OrthoDB" id="1612078at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="1">
        <location>
            <begin position="74"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="678" mass="72626" checksum="D9682F5F34FAAE2B" modified="2014-03-19" version="1">MHAAKYSLISALVAATTASHIPHRAEQGLAVPQIWSSPLFKSSAPFHGPSSAKESTLTQSFQLHEPAPLLTSSAHSCSVTLVSRSFANSYGSPSTLSFDPRTAFAGTACSDPDEWTGLTLDVHGETRGRQFDRLGTVWVGNNATGQGVEVLRLDNPEPTKQGVYWSTKKDVGKYWPLWSQPADVVFDLPNIVDDTYTGALNVTLQLTASVQGSLSRAGRKRTHAGRIPALPLKQRAAHLVIPLSKRLQTGNSIFQLGGSAGNGTASVKVPHNAARALVEVYASGTAAEEFWYTGITDRFFNQIPDAAANGYYGHGPYREVQLYIDGAFAGFVTPYPVIFTGGINPLLWRPAANYGTFDQPTYTIDVTPFIGTLTDDQPHSFELAVVGSERGGVINDASWFVSGNVQVYLDSSDGRTTGKVIKATQGAEVVKGTTGGSIKGDPLTNGSLTYSVGLQVPRRFDVAGSVKTGSGKEYVAAWSQQAEYDNRGLVNATTQTNDQKSFGWTRSLVIDARHIDKVMGTLDFDAIQTLADAQDAKVQVSAVQMDYNYPLYVTSSLSNTSFDARIVEQFDRTVRRTGPGTDKDLTKMVGDETTLVHADPVAALPHAILSKRNADADSVLVNGAIANGTGTARQTYMYRDMAGGTIDRVTRTNTTNVLQDSLAGSVSARAQPGQLTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ44</accession>
    <name>W3VJ44_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04192</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001040_1_0_1"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000061">
        <property type="entry name" value="Oxysterol binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000017">
        <property type="entry name" value="Oxysterol-binding protein homolog C2F12.05c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="264"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="398"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="640"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="930"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="930"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="953"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS61693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1292" mass="143168" checksum="F5DA59C4DE1848D3" modified="2014-03-19" version="1">MSAPRPSTNTINGGTPAGDEVAEAVYSFKLLEALRKGDQQALIPLLQPTHASQNHLAKESTSPLHLAVRCADFNIISFLLNYKTIDINATESQHGNTALHIAAASGRDDVVQLLLEQHDIDDSKRNNDNRDALEVSKTPEVAQLIQVSRAQLNVKYVDLLSAYEQDTQAAEQAIHALLDLPRYSVIDLNAHGANGSTLLHEAVRRKDTRMIETAVRKGADVYARDRRGKRVGDVTKDEKVKALLRQLHNADAARASQAAHSGQPPSFKGYLGKWTNIAHGYKTRWFVLEDGILSYYHSQDDEGKQSRGAINMRYAKIRADNNDKHRLEIISETGKGVSKLYLRGTHPVERARWVQVLQQTKEYFSLERQTSRADSFYRQRAPSTSSLHNGASATAPLANPAGIVRPSSTAPLANPAGIVRPPSAAPSEKGSRALLSIKSPTTQPPSGAPSERSLQLANRSPSILSRLSSDGRLDDENENGATGGAMPFESEFPLTAEALKAQAEASQRLVETLLGAGAVAAPAVSSARNSSDEASAAAAKSSRSNRSSSASVSGNNADAVRSALDAAVRSNFQLVERYQAMVAARETYMTKRYERELQIKHLWEENMAVLAQQHAEMEAQLKEAASENARRRKALREVRETMGSSPGSMISPSLGPSASTGSVLHNPEPRRQSTMLSNTFEYMRPDKKYRYYSEQVSHHPPISACFAQSPTWEYMGCVDAKSKFLGRTFEIRPTGVAHVNLKVPKKWVRSDKELKPAQMLQDHVLEHYTWNKVTTSVSGFIVGSPTIDHFGDMEVTNHATGDRCVLTFKPRGWRGKDAFEIRGSVYDAQGKLCWDIAGRWNSQLVARKVGAGSGDLNPDQSVEAPDGQIAVAQPLAEYLLLWRNSDKPPTPFNLTPFAITLNSCPDDLRPWLAPTDCRLRPDLSAFESGKFDQANDLKQKLENHQRETRRKREQGELPPHEPRWFKRTTDQDTKETLWQPVPAPPNSGPGGKETTSYWAERHHVGSKKKEGQQADWNNVYHIFGDFEIVLVMTSVNTAPVPLPSVGKQLIVFDFDWSLVDQDTDRWVHEVLCPELRAELQRRKKGEQFTDLCADLLLKLHARGVTPDELRDALRLLPFHPGVKRAISTLKQTAQPNTTLFLLSNSNTVYINTILAHHNLEGLFDEIVTNPAHFTPEGALKLERRIAPSAVQHTCSVGCSANMCKGDELEAFLERHGGRDAFDRIIYVGDGGNDYCPVKRLRTSDLAFVRKFRGLQTRIAREAGVKAGIKYWNGAWELEGYLNEARGVPALDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ70</accession>
    <name>W3VJ70_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ70"/>
    <dbReference type="HOGENOM" id="CLU_059257_2_0_1"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="225"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS60847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="318" mass="34580" checksum="E0C2A6F0ED10C97C" modified="2014-03-19" version="1">MSFNDLERGSSSSRGGGAGGSGGSRKTPLPLYRDEVSNTLPPEFEKLTSKIGIQIFKINSNVTAIQKLITLSSSPSTSSAPSKAAGQDWSKRINDLIETTRELVKDVTTDIKQLSTFPLGSASGAAKLTQAKLQRDFQSAAMQFQRVQKDAVAKTRAKLEQDKQKERQMLRSRNSQLLIDTEEADRGAASSQQQQQAGADAGGLQAESLDLLPEGPSQADLEYQESLITSREAEIREIESGVQELNEIFRDLGNIVQEQGGMIDNIEFNINSIADNTAGADRELVVAHEYQRRAGRRCICLLLVVGFVVAIVLLAILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJC3</accession>
    <name>W3VJC3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJC3"/>
    <dbReference type="HOGENOM" id="CLU_602940_0_0_1"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="448"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="56621" checksum="E91C07D564C3A54C" modified="2014-03-19" version="1">MLRPNTSSSKIAAWQCTQKFRLRKFYSSSASTQHPCFGLRGLEPTPLATTYIPTSDTMDQDMDLTLSGAARAPALASTSSLYRAQEPFHVQAIPPHAAPNASPAYVTHLVSLSTSYGVPTLLAVADDSTLTLIDKVSGVVAESQRAFKDARITQAKPLAPGSGSFVASVSNGTVACWDTRAGLARPVWTLQGASKAPYLCVEPAPHDANIVVAGTEQYGHGDSDIDIWDIRSAAAPQSKYNEVHSDDITVLQYHPDAVNHKGILLSGSTDGLVSAIDTTIAEEDDAVISVGNTGNSVARAGWIYSSTPSSSAAAAMDTAMEDGGEESDLRQVETEARRRALGKVWAIGDMQTLSLFDADKFDPLLPTTDVRSSNSLRPPWSTDYVIDAFSTLPSFPNPTVAPGAEDLTLFVGRSEGAFAAISIPISNPSQLSSWHLRAVFPEQGDGTLYGHADIIRSAEWDPKTNTLYTGGEDGNLCFWNFDNNAAATPAAVSIPTLGSYSAPAASGSDSQASSRSASRNHTPARTQRYTPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJD7</accession>
    <name>W3VJD7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJD7"/>
    <dbReference type="HOGENOM" id="CLU_100686_0_0_1"/>
    <dbReference type="OrthoDB" id="5563033at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="241" mass="26524" checksum="D3193E41CF8E06FB" modified="2014-03-19" version="1">MHASRSPKSDSAQIGKISNRCHAAEPHLCLPPAPSTFTLIHSISQPRLFLLSLSVWTHTMYCLRWWIPLFLLPFPHTSPLFLVLFLVSFALHSQPCIYCALILTGLFTTSSNWYGPASTIVPAIDAANDTAQPRASYGWIDLGLSGGNGFFNPMARPRSASAPTQPADEDKVEGDDFFRLTIPWSDVEWNVPKRFHVGPSKHQGLGFWIDLGSKLDSPPEPAMQAASTPSLADTSSQHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJZ8</accession>
    <name>W3VJZ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJZ8"/>
    <dbReference type="HOGENOM" id="CLU_071330_3_1_1"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="266" mass="28279" checksum="AC74F45BD64B872B" modified="2014-03-19" version="1">MATTTAVTAVSEATAVILGATGAVGTPLLGQLVSDSSPYTRVVSFARREHPAPPSSSKVKFEEVVVDFEKLFQKDASEQAKFAGVKADAVFITMGTTRAAAGSGAAFEKIDRGYVLAAAKALHDPKHPATMVYCSSGQASSASRFPYLKSKGLTEEGLASMYAKTIIMRPGFLQNAQRKESRVFEKLSQPFFNLGAKISDSLQADVKDVAAAMIKAAQLGPEKLNDQVLATPLPNNFRLEPEAAGHQIAIVLNNHILQLTRPAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK01</accession>
    <name>W3VK01_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60s ribosomal protein l23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK01"/>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_1"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="136" mass="14427" checksum="D0AC01682744AB9F" modified="2014-03-19" version="1">MSKAAVGTKFRMTLALPVGAVMNCADNSGAKNLFVIAVHGIGARLNRLPAAAAGDMVVASVKKGKPELRKKVMPAVVVRQRKPWRRRDGVFLYFEDNAGVIVNPKGEMKGSAITGPVAKECADIWPRIASNAGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKA0</accession>
    <name>W3VKA0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKA0"/>
    <dbReference type="HOGENOM" id="CLU_028760_5_0_1"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="78"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="633" mass="69043" checksum="A2839E9598B28347" modified="2014-03-19" version="1">MLACRPPSSAALDTMAHNDHLLPRPREIPGPTSPQSSLLAGRQRYLLFPRFTLESGITLTDVPVAFKTWGRLADTRDNALVVCHALTGSADVEDWWGPLLGVDKVFDYSRFFVVCCNVLGSPYGSASSCTQAGGESSWAQHGDDAAAIDATAQAKMQWDGQGWWGPEFPATTVRDDVRIQKLVLEFLGVESVAAVVGGSMGGMAVLEWPLVFPTRWPGRADSTARYIQAIVPLATSARHSAWCISWAEAQRQSIYSDPLFKHGYYLPAEPPRNGLSAARMAALLTYRSRDSFESRFGRRVGKALKGGGAALPVPDAHSEAQAKTLDDQRRRSLAHDAAAAHNEGNLSPRVKPYGSNSPLNGYFAGPNGASLSPTATTPPVPAVPHAPTELSDQAVERLVEPFSPSTAPEIFSAQSYLRYQGDKFVRRFDANCYIHLTRKMDTHDVARSRWGWRVLRTSDRITGVVLDSGVRPETEEAEDAALMRVLDVLSAHEAVEGKVQPPAVLVVSIESDGLFAPPEQMLIHDLVRGSEFVSVKSSDGHDGFLLEFEQINASVGAFLRKTLAEIYQRPRLQVQHQQQQVKESVFGEVEDVTRCIQLPRSPLMTILASTGLDPLLQGARIPSIQLLTAHGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKD5</accession>
    <name>W3VKD5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKD5"/>
    <dbReference type="HOGENOM" id="CLU_460197_0_0_1"/>
    <dbReference type="OrthoDB" id="3355480at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="711" mass="78100" checksum="78CC7F394355C7D7" modified="2014-03-19" version="1">MLAVPTPSTSRFQRSLYDVDRTKPSPFAWTSDGRTRRYVRRMGLIESFFNTMATLHEGRTDIFYRIPLSCPTQAYEHLARRLPLVWAILCRRHPLLGAHVETLTPDGTRIDAQQAAATRHTGEAADDGSISFEPHFVFDAIASASDLLESASKRVAFLPPTWCDDPELRAYARGSNATRSGLVVSWLDRYVWNDKRRFLEQHTPFGLAQLILLPPAATDTATDSVDFDLMLCSAHCISDGLSISDLAGELVRLLASSELPIQLHELEHRTEPSVGVPGLSTARYAQVSSQMKHAVRTGLLCGRHQDGGPNDDGAIEDADWTALLPAPIEAAYPELLPSAASTAGAAGSGAERSRLARARWFWTIRRVVVQIRAAKAESAVLSDFKANRTDKSVEEPWWGAQTRWSAVRLSAEDTSALTRVAKRKGVRVGSLLYSVAACALNTLELTHTPPGSRSEEPTSTVMGFPFSIRRFLAPAAAETHDPLLVPSSLGVKLSFNGIGLPPASLFSLNAWPSGATRQVLSLSGFECAQLWQTARQVQRQFNAIFHEPRFMHADGFLTALEREMRFRKNGVKDVFQVFKDDAPAGADERTPGLAKKNMQGPGSSLNFSMVGLLDTALPSRLEFVVPSADVAQAHQAVLEVRDDLLFGVRTRAGEAFGTSFTFRGQLNLELGHDTVVWDTNKVLDYLGLMKTILEALVAADEARWKEGKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKT1</accession>
    <name>W3VKT1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKT1"/>
    <dbReference type="HOGENOM" id="CLU_2085801_0_0_1"/>
    <dbReference type="OrthoDB" id="10296451at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="117" mass="13145" checksum="82866CF3E46E0E8C" modified="2014-03-19" version="1">MPRTYGMPARPSSASEQAERAGKATGLTLPTSLVSRRLPVDGFGREEQAKWTSDDTHSHREIEQPDEQQNKIDLQSTWLNPRFAGDEDLHIQQRHRLRETAIAAAPMIRLSGEQRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKZ0</accession>
    <name>W3VKZ0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKZ0"/>
    <dbReference type="HOGENOM" id="CLU_739659_0_0_1"/>
    <dbReference type="OrthoDB" id="10490946at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833067" evidence="2">
        <location>
            <begin position="23"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="375" mass="38071" checksum="37D08FD59369C67D" modified="2014-03-19" version="1">MMVSLSPFLGALLAVLVAQGSSKPDSDFRWGYSKGQIQAAMSTMRSHYGSNYQSQISTLCQSLLQFNGTQGSTGANPGSDQSDESSKGNDDLADLLDTQSAEGDGLERRARKQAATRHANARNKGKPHLKGSKAAKTKGATAAHDAALATAKTSKAKNSGGVAAKAGTFVALDAGSATTTPGTTSGSNNSTSLGADGDAPGNGTPGPDTNTPASTTMPDSGTTTPGTGDTTPASDTPGTTTPGPGDPGANPGTGTPGSVSGAEVTPPPFVLPPFLRHMDQDIIQQVCRIMVDSSQPGSWTPKTGDDDEDDGDKPGRPWDRWHGLKPGPGPDGNATTNGTGWGHDRKPWTMPTATVTVTVTQTATVTVTVDAAPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKZ7</accession>
    <name>W3VKZ7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKZ7"/>
    <dbReference type="HOGENOM" id="CLU_858229_0_0_1"/>
    <dbReference type="OrthoDB" id="3358788at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="305" mass="32205" checksum="AE02787E1B153BBD" modified="2014-03-19" version="1">MSFSLLSTQPLLRGSQLAARTLGAAPALSIQAGLVRSMHTRPTTPAGPAGRRAWPLKTLGGGLVAGGGWFCLGTTSEQRSFSIHSPAESEAAITGSSTLVRPASPSAPRRQTVTLVFVTSQATRTGVVKSLMSSLAGGSGEQQKWLSWIGYFREAGYDCIQMNLAIPETGGDLADELHQQIRLSNLQRQPVLFVHHSGDADEAAQAVGRYIQPGQAAGGFWSRIFGGGAFGARPAISGLVVISDADAAQASQLFTKHPKLNTLVVASAAEEGKKGKATLMDAEKKSHEALVKDIERWLIREGYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLC6</accession>
    <name>W3VLC6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLC6"/>
    <dbReference type="HOGENOM" id="CLU_011083_0_0_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="555"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="830" mass="88862" checksum="A0666746B7CD6914" modified="2014-03-19" version="1">MATPSEQSSAPANAAPPTDTATAPAESTLPTNTAADPTSTSPLQSAGSVASASMLPRSTALASTGSAASSAAPGSGSATPTPRTPNTQAAVSPRRASSSLAHNSSSVVASREPTASARRIRQHTFSSTASAMASTDGSNVIPSMFGHPFRADSPAGFVGPRPSHTTRIQPAWVRPARSQPSNPRDTTAPNSSPNATHLSWYSTPIHSHPHQPQPSASTANPSHRQPHSHHDPPAAQHRAAPAFVPDTQPTFEETTTISFTWTIRDLHLLREEVEHSPPASEGGRSVSAGAGKSDIWTNPPVFGDGKWKLELVRTTRSLASPSHESPHTPHHARPSASVDSTDATSSPTTASASITILSVYLTALVLDYTHANVEIPACIMLGLRPVRAPVGRREDGGWLWRRFYDYTFHKDADLFTCHHLPSVSQMLQDDQVARQDAIALTIQLGLGPGHVRELEGLLGHGAVARVPVEVEGHHLVPRAMLTSLHGLLDDANTGDVRIIVRERGIRLPQPDKDAAASDDEETSSARSARIVPFPIGSAHPAQAQGEAEGEEQTYVRDRVLWAHASVLRSRSDYFGTMLGSEFSEGIDHVYGSGARRVRTLRIPDADFATAYWFLRYLYTDEVEFAPNEDVRSAVLDDEWAKPGQHAEGAQGAGEEDVLADWTPVSQLDQEAFGIEVGHGREVSGSFVHSVGTSGSVRRRTHSQATSPVDEGEGWDVHPHPSCAPGAASALAVFRLAHRYELHSLSRLAAVHLVDTLTPHSAFPTLLATSMYAELHARIKAYVYTHWHHVAATHEFQTCCDEVCTGVWGARAGKTISAFVASLVSPLVQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLJ6</accession>
    <name>W3VLJ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_04112</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLJ6"/>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1290:FF:000002">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="15">
        <location>
            <begin position="14"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="14">
        <location>
            <begin position="176"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="259"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="571"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="682"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="840"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS61621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="861" mass="95603" checksum="B707404CB4D26C7F" modified="2014-03-19" version="1">MPPKVDVNDPENARLLKLFESLNLSGNRAIETLTNPKHTAALESVITDNQLTSKSIDPKASALIVSASTGKDASNKSSRDYVVSRILDGSLASSDQLNAAYKFLANTTGQPDKAAFDAECGVGVVVTPDQCRSAVEAYVASHRAELDPVEGWPKLGSILAGVKATPEMRWASAVDVKGAVDAVLLATYGPKKAAPPKEKKKPAAASAADAKREAAPTGPVDPDAMFKEGFLANLHKPGENPQIKPELKQQHLAATKGMVMTRFPPEPNGFLHIGHSKAIAVNFGFARHHGGLCYLRYDDTNPEAEEEKYFTSILETVRWLGFEPFRVTYSSDYFQRLYELAVELIKRGKAYVDHSTPEEIKEQRGGPERGPRKPSRFRDRPIEESLQDFEDMKNGKYPPGKVTLRMKQDIENGNPQMWDLIAYRVLEASHHRTGKDWCIYPTYDFTHCLVDSFENISHSLCTTEFILSRESYEWLCDALEVYKPRQSEYGRLALQGTVMSKRKILKLVKERYIEDWDDPRMFTLIALRRRGVPPGAILSFVSALGVTTAKSTIQISRFDQAVRQYLEFSTPRLMMVLNPLKVTIENLPEDHYEQLEKPLHPKAPEMGTNKMPFTRTVYIDASDFRTEDSKDYFRLAPGKTVGLLQVPFPITATSFKTNDKGEPIEVIATYGDASTPKPKTYIQWVAEHAPSNSPVKVDETRIFLQLFTSDDPAAEDNFLEHVNPDSLEIVRGAMVEVGFWDVAKRSIEQARIEAAERTNKAEADAAKAQSETQTPEVKEAGAGAPARTAEQLVGKELVRFQGMRTAYFALDRLSGDLGLFGDKAPGGSIVLNRIVSLKEDAKKDDKKTPAPPAAKPKKNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLU6</accession>
    <name>W3VLU6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLU6"/>
    <dbReference type="HOGENOM" id="CLU_030988_5_1_1"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="33"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="224" mass="24290" checksum="B9F98C473E91791C" modified="2014-03-19" version="1">MTSSMASTAFTDKWTQSTPLTLQHLDSTMVSPSVIKVLARELATLAQSPPDGIRVSLDDADVLSFSGWVSGAPSTPYEGGCFRITFDFDGIDFPVHPPRCRFATPIFHPNVSSAGEICVSTLQKDWTRNHGVQQILLAIKCLLIHPNPDSALNPQASSLMHEDWQAFVQTAAMWTQVHAAKVPPCFQDAKQPTPNTTGKVAVAQPPPRAKAAAPPAPRRGLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLX4</accession>
    <name>W3VLX4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLX4"/>
    <dbReference type="HOGENOM" id="CLU_008220_0_0_1"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="862"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="126"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="500"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="888" mass="98236" checksum="E8B219AFFAD7FE28" modified="2014-03-19" version="1">MKRTDSASSIASLPSLPTFNHSLTPSSSNAGHARARPFGDYEDEMEVIESDDEDRHVPSSSASSSSNHQMGSSSGKQRHGSSRRTDSYILTTSPSTTSPGSFTFHSTSEDPSEAGASTDAIHASLVLARHIFSVAVTEKWCRQDNFSNAVAVRVNVGSYILYPQEGSSMPAFSRAMLELNCDAAIIINTPLVAAALSTLNQGENEIRLSSSKRVQVVRSLDYLGGARRAQMAAFSDTEQVLVIWTESCRDLIEQVRAFERLLVDYVWSITADPTASARHSMVSRSPSLMSLNTAVENTVVSSASAESDLAQLESYVPEVRKTECVASCVSMAIGPIRPMMRNSRYYSGVSPEPPVGKTILPHVTIQVPVYKESLVQVLQPTLDSIRAAITEYELQGGTASILIAEDGMLVVDEEEREARLDFYRRHDIAWIARPRHGDMFTRAGRFKKASNLNFSMQISKKYEESILANPNQDRESLLQHILKERHPEATGEGDVSIGELILLIDSDTRIPADSLLPSAWEMASSPDVAILQHCSGVLIVGSGFFEKSLAYFMRFIYFFISWQTATGEVAPFVGHNAFLRKSAIMELAEESLGPKNSDGLIKPWSEETVSEDLDVGLRLLLRGWVTRWVTYSNYGFQEGVSLTYVDEVNRWRKYTFGIFELFLNPLWRWPVQGPVPKLIRTVFWSNKVPIHYKFHLLAYAAGYVAIGVSLPSALALYFVSGWLGPWMLPFFVPSFQYWVVSLVIFGATGALGVTIARHRSGDANIFRALAQFLLWYPINLITIVSLSIPLAKAMVSFLVSLPVSFGVTAKDDSNFHFAKEAPLVLRHFWQSSTICLAIVAGVSVLATSAVPITWQITDWPTMLPLLFISVATLLSPFLLNPALIRFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM30</accession>
    <name>W3VM30_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM30"/>
    <dbReference type="HOGENOM" id="CLU_026313_0_0_1"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043452">
        <property type="entry name" value="BZIP46-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22952">
        <property type="entry name" value="CAMP-RESPONSE ELEMENT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="210"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="674" mass="69756" checksum="133DB3EC42FD8C5E" modified="2014-03-19" version="1">MDTAQHSPRVPHACRAGAAVDVALAAPLALAPAHSGSTARIPKSPATQPRPTHLSTTTTRLLPFLLDRATLDLPRTHLPLWQSDFVAPSRQLILWAISSSSLSAGEHSLVSSSVLLCLATSFQLIDSTKLASPSSLAAHTTPSSSSAIPSSSRLPDSTSSAKKRKMDDAHDDEDNDDEEDDLDESSSASNSPSKAANTGGRRKASDEERKARLEARQARNRLSAQYSRERKKAYMEQLEGSLNALKTENTLLRQQRDQDQLVRQSLESKLKEAQIRVHTLETILRTVAPSLVPLLMSSSSSSSVSLPSASLANATSSTLSTAPQLAAESSVDLASALLQNAGLASRDVPLSVPIAAPASTTSSTLSPGTPAQQSSNEDFDGVAGNGAAVPKVGSNVDANGSSIVAQGYPLANQISVPAAEQPSSIAADSRSALCEPAAEAKASGAAVEAEAILSHFIDLDAKFANSDAAAAAQDQGASAPATSTPFVPVGEVHAAAAAGGALRSAEAPAGGLEGLSTVFAGAHDASKATDISHGDTFKFNTITLAPTHVDGSKEQDAQQRFALLNSALLPSERSVWELATDAMLEDIYGKAQDTEADSADTSLAATDASSHSEGSVGSSPFDLVDLDIEIEEPMQLHIQDDSASLDASSMLATGHHVKAEAGMDWPGLLASLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM59</accession>
    <name>W3VM59_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003568_0_0_1"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="957"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1475"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1132"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1176"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1257"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1297"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1365"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1395"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1435"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1476"/>
            <end position="1490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1595" mass="168331" checksum="1BD8330BF5B90AAC" modified="2014-03-19" version="1">MPARVASADGAAVAADRLISQLSRGLSAPSAAADTADSLSSALQSLQRHARSFGFSSQHCDQLVRLALIGRLRLSTAGSSAKHKAPKTSVSLTILRSVIPRPRAKLGRQAVLDIVAALGPSPGTDMIKLSGMQKDDTESNLGPERVKVDSKVQVAALKLLCVALDSPSVPLSVAASFYTDSNSDSAPTTRRDRDQDGRELERLQRHAAQYSGLPGNLPSTYLTALARTTLEKCYATLFHFIDYQALRPHICYLLCRVTKRKHVRHYRITKLMALRANAAPELGISALLSTYANFYPDLLFPELLGGGGASSAAGAGPVGLKYPEPDWIAAILLAHARCARRSAGDAVESDDEADNDSESAPGGMQRATKKQRLSAKNVKDGGADENAASVLGVVSASIPIPNLVTIQPLNSAQKAFGTQPSLVTELSSLRHLAHSLDRLVLPSQAAAMLGTGFGARMMRVAVLAGATITNEESLSQAAPAARRGRQTEHDACWVRLSDWLESVLGDEIGVQSSAASASQRQHLRLPSTDAEFKRLASLLRRARLMFELAEQMPARLEGLMSSVLLAIARVAEPGRDDADAWTERWDELTREVLKFVPLVMPSDLSSFEDRFMTPLEALARSTRVSLDTSAAVLLAINGLLTNWAVRDWRDIGARLDARKSYRWGISNLDPSVDFGELIAATSARADRLAATLVGLYPRHVAMEHAVLSLYEGLARHLAGMGTVASVPALPLYAFTLHATTIVSVSRLCGLIQDLRHAFEHHNAVGAKLPAVDGGLESKFYDLSASFFEEENLSILNSRVTLVANLIWLGKIVTEDEAVGSLPPGLEQSVLNELTQRGDDLNLKLATLSNTPFSRAMSHLSERFANVYCAGQGKKATGEDEWIRGPITPKTIKSAKKNGMPAAWTHTDFRAYLLDWLDTQGAHGMYELLKNILVTFGSQLKSIRGEAAAAAHRCPPTHTMDAFGDSDLSDISAPPTPGPASTPRAASPDSEPEPAQPPSSDLADDAPKPAGRSAARRRSSARVTETAAETSSKPSSSRKPKASPKASESADPADDAQAPATGTPSLNRKGSTRNRKATAKLRSPSPLTDHADKPSPAGRGKKKANAAPDKPKSGIKVKLSIKRSSADGRATGDSGSSRASTPQPTVSASGTKVTIKPRGKNKFADGLRDLADDDEENKFADGLRDLADDDEEVPGGSALAEDAAPGDEAMPDAEAADGDGLGGARRRSTGKRGRDYRNKPTGRRRVVVADDEEDEEEGTGKGAEEAPQRKRAKLSDNAADGGRADARPARNTRNTIDYSDDDDEDEEMVDVASEEDDLELDAAAAADSEDDFEQDGASSRRGAAKSKSARGAKSGGRKSTGGAGGSAAKATSASGAKKAGAAAASTAANKGMSAEARMRASIDAAKDKSLKPPGASVGTKLNPQANAFRPSGAVKSGTSTPTGAAGASAPKRPASTGKPAFGKSMSGWDQLFGGISGLSSSASTPSKATPIKPGAPSKPATPTAGVSGSGIRQDPVLEAASPADVQRLKNQATQQYLCTDECFDLLAHADIMTAFERSIGIEDRKLAARLRPCVYRAGQALLPKLQPPTQPTQSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM66</accession>
    <name>W3VM66_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03996</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM66"/>
    <dbReference type="HOGENOM" id="CLU_013359_0_0_1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="501"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="501"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="724" mass="78804" checksum="D37D326C35CF0720" modified="2014-03-19" version="1">MLDRTTRLAAVTELDWWRLLPLVHSHRLGIGTRSNAPLRSSCLASIATMDGRSAGPDPPPDPHAVLQQLIRQAEARTSSSPSSSQRNGQDHDDHSNVPSPSSDASSPQAAEEPPPGLLPYEHISAIIASLSADRRELTTLLRQRKLLHTAHQRNTAHQHSLERSLALLAKTRDELKSALGSLDLADIVDAEDQSLEVIRTHRLAEDAASVCPLPPAAVQQIPLLRLQSIERAEFDNALASRMWIDMEDQQIRAAVKASALKAHTIELSTDPNFHGDPLAAAAGLDDDTVFRLAEQIELSAQTAPSRGATAKGLDWATIAGRVDGRTIDEVRTRWNGHLRPGVNNAPWPKEELDQLISIVMPHLSAHLSRNKDSNSGVSTQAQPPHELPVPWQRVTDELRTGRTAYSCFAAFCEALVSRDQPEVEPVEDEESKVLFSLFRGAWRLMTLHSSATPNASASALLPPTASGSDNKAGASSRSASILGKVARHPQYAYRRFRNTIDPAMATGKWLPHEDLLLIEAVRLLGADNWGPVAARVPGRTTHQCRERWVRRLKQLVASADTAATTHAQAGPKTTPAVHAQFDVTQLKDLLATSRKVKWTPEMDHVLLGYVDAAQDYRSRDASTFGRIAQLVGAKVGVALSDKNVRDRLVYFRRQRDSAMQKTDTASEAGSAAAGPAKRAAEGVATEPRDEAEMSSGSRVGAGEARDEMPARTAIMPGSKRQKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMC8</accession>
    <name>W3VMC8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMC8"/>
    <dbReference type="HOGENOM" id="CLU_015590_2_1_1"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="350"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="659" mass="72153" checksum="6924A413A80D5158" modified="2014-03-19" version="1">MSQAGARILAHKAAHLPCAVTPGANAIKTTREVLGLIQDKNVDIVIPRLEGKNDVCRCDVYRPKDTEDGKTYPVLITAGPYGKDIAYSEFYPESFAQLPDEQKSELSAWEVPEPTFWTRHGFIVVRVDEQGTGQSPGFLDTMSDQTANNFFHCIEWAASQSWSSGKVGLLGISYYAGSQWRVAARKPKGLAAMIPWEGMSDYYRDRVRKGGIYGDGFVTMWQNYQINSNQYGRAAAPPPKKTWGPGRNAKVPSIEGVLTPEQLRENRTDQTVDNAENFFLDQDYYASREFDLADIETPLLSVGNWGGIALHLRGNVAGYLGAGSKMKWLWLITGRHDLPFYLPERVALQLSFLNAFLRGQDDRGWLKGPNADGGVPAVSYVVRKGSPKFNTIEGDRSFPEKIANSWPLPNTIYTPFFLSADHQLKKDRQAAAVATNGVTSIDGHQPSSPEQVAYRGFDGESVKFEHKVEGSEIEITGHPHLRLLMSVAADPNTGSVPSEIDIFATLRHLDAAGSEIFYTGTAGDPCPIVKGWLRASVRKVDQAKSTDLVPHRNYLSSEIAPLKLDTVYALDVELWPTNVVIPAGHTLQLEVGPQDQQGGGVFTHTHPQDRVQAKLAGINSIHTGTVDAGKVDTIGISAKTPALGNDVLASCLVLPVIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMH3</accession>
    <name>W3VMH3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMH3"/>
    <dbReference type="HOGENOM" id="CLU_052388_1_2_1"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="157"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="372" mass="40911" checksum="7FAB3B200BAFA727" modified="2014-03-19" version="1">MMGHRAGELSHARSSQQRSDHAASNPTLLQSFVTIILPSLLSSDQPQTHTHESSLPLFVIMATSLFQVSGDPDTDLKAAAHWLAEQRRRPIRAPHKTVRYGELIISKGGLASLQDDELWSLLEQVAIAAIETSRFDLAELCISRLTSRFPASKRVTCLQGMLLEGRGPASAAIEFYDAELAKDPTSLVLSRRRIAAIKALGEPTPKRVVEALNRHLDTFYNDPEAWQELAEIYADHAMYAQSAFALEELLLQVPQNTFFHLKYAETLYTNGDVARAYKAYLRVLELCQSDAAATEATAQGPWIRALWGTKVTTAALIATPALGKATPDDTIDSAKVKQIDQLATTLLLNKVYTPKAVASKHLRDTVRSILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMY0</accession>
    <name>W3VMY0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMY0"/>
    <dbReference type="HOGENOM" id="CLU_021264_11_2_1"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833118" description="NodB homology domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="10">
        <location>
            <begin position="82"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="303" mass="33025" checksum="F18A5F6D77BB6DE3" modified="2014-03-19" version="1">MRFSSILAVGAALSAGLVAPVTASPTVMSTIPNHISENVRRELAALPAEDYTIYERDVGPSSSLAKRGAQISGVQTRCTSKSCLSITFDDGPYQWERKLVDTLGDAGGQKGTFFVNGNNFRCIYEDAQVQNLRYTYERGHQICSHTWGHPDISTLNNAQLDQQVQLVEDALWKILGVVPACFRAPYGNIRPDQVKYLNDRWGYVIVGWNEDTGDANGDGVEAGLNLYRNLKAPKHAIVLNHETVAGTVDTVIPQAVNIVRQNGYKGSQTVATTLGFNPYKVVGKYGTRDGSWTCNGKPQPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN17</accession>
    <name>W3VN17_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN17"/>
    <dbReference type="HOGENOM" id="CLU_696708_0_0_1"/>
    <dbReference type="OrthoDB" id="3361566at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="396" mass="43077" checksum="9DB832C8F5E03B4C" modified="2014-03-19" version="1">MAKGSILPILTLAVAGVLAFAATTYTAFLLSPDNKLRALAQSCNLPSRQKLPTDFTNGALPLLDNTLCTTMGFFKANTAKRLNVGLFSIMIAFTLPLSYRLSFQAASPNRKSLLNSGVFLVPLNIIGAAAGVGPWSCLFYTFVYLPAAYSSMKASKASVLPVPTPSSNIYIANLVHVLFGTTVALAVFADPEGALWHHAALAIQFAGLSYLPIAWLSLRTPKVNDEVESRSVIRRFDAEGVSYAFERTWSYYRKMAAFSAFIYWYGLNRIIRGVWVNGERLDAFSYFWFGDVGGVALALILLVAAEKTTFRNKDAIHPVSGEPRSPLDIECDKAIAKAPAGSPWLEKTTTGFIVASLVGGPGFAASMWWCSGEEELGWKARKSWRETVAVDGKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN39</accession>
    <name>W3VN39_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN39"/>
    <dbReference type="HOGENOM" id="CLU_026535_0_1_1"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="359"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="455" mass="49865" checksum="FF7F9E109C7E5038" modified="2014-03-19" version="1">MAARPSRYLVQPISSISIAPASQSNRSIQQPRLSSQPQHPVTQHIRPFLQPRSQHNIIRRLWTANLIRRANVAAYADFDLACPNHSQNVRIASIFGIAPVNVRGLDGAASGSLPLPAVFTAPIRPDVVQLVHTNVAKNKRQPYAVSTKAGHQTSAESWGTGRAVARIPRVGGGGTHRSGQAAFGNMVRGGHMFAPTKLWRRWFIKTNQNQKRYATASALAATAVPSLVLARGHRVEELEEIPLVVADAAEGLTKTKEAVALLKAVNAYNDVVKVSNSRKIRAGVGKLRNRRHTQRRGPLVIYNKDAGIVKAFRNVPGVELCSVERLNLLQLAPGGHLGRFVIFTQSAFGRLDEVFAAKSGFTMPKAKIANTDVTRIINSDEIQSVVRAKGPAKTTRPFTQRKNPLKNRAVLFRLNPYAQAAIRSEIRAQAQKKSGFKKEAKQPVAKEFLELLHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNB5</accession>
    <name>W3VNB5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_02789</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNB5"/>
    <dbReference type="HOGENOM" id="CLU_015166_0_3_1"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="164"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="266"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="396" mass="41565" checksum="A4EFF34BAA3E059A" modified="2014-03-19" version="1">MAAAASSSALPGSGPSSSNVAREAAATAKAGKIPPYATLAFGAVSGFASCVLLQPFDLLKTRLQQLDHHTASGGAASESMASLKYQSRTQRLIGITKNIVQSQGYLGLWRGTTPTVIRNVPGVALYFYSVSHLRHVASQRQIPFISVVATTGDSAAGSSTLAKLSTTGNLLTGAVARVAVGFMLSPVTVVKARFESSNFSAATERTLLSSMREIRAQSGFAGFFQGFTATALRDAPYAGLYLALYEACKTNLSALSKGVDGGLGTGNWMVVSGSGLLAGTLATFLTHPFDIIKTRMQTTPAEALHQIALTDNPLPVTSAATATFRTPSVWGMTKHLWATSGPKALLDGLGLRCARKAASSAIGWSIFEGGRSWYTDRQLRIAAANQTTRTLDHKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNC1</accession>
    <name>W3VNC1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNC1"/>
    <dbReference type="HOGENOM" id="CLU_1455004_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS62257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="186" mass="19961" checksum="FE825743698333A1" modified="2014-03-19" version="1">MIGSTKDFELPVGPAHDHILTPVASTPSALACRASPCRASPRLHQNRAFGSGNRRGMIRRLPHVCISPLMAAQLPVGPERIRLGPCLSMLHMHAAAVSRWLDARSVLLQPPSRTAPHRIASPRRTASRLWAHLASPRPASEYVSSPLLPPTEAQSKLFVSKVSVGLGPSDPLAARFIPVLAPSIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNR9</accession>
    <name>W3VNR9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNR9"/>
    <dbReference type="HOGENOM" id="CLU_564983_0_0_1"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="50157" checksum="79367541AAB31012" modified="2014-03-19" version="1">MAQSLSALSSPSRAHLFRGSPQHVSSSSSSSLNISFPTPVAVAPAALTPASAHAASPSQASTSAIHMLSAPKSTPPRHTHAITAMSPQSHPPSATAPAPASAPTTAASTSASAPAPAPAAAAASAAAPASASNPKMLPYLFDDAQLDDVLVLVVDMLVKLTEHNDGLPLHPSALTRFHSRATPNISLSAYLRRIAKYTSIEKCCVLILLVYIDRVCERLEGFTICGLTVHRFICAAILCASKALCDAFNTNEHYAKVGGISLQEINLLEKEFLQIIDWRLICSGAVLQHYYASLVRSHSCYVLAPPPADVQMPIDAPGASAMDEDDPNAPVLASTKPHSHGDRSEVLDSNGARLRGSIALTSAMAAPNSQHSSPLPLSSNSASPFTPASVAGATRPHGGMVAASTSGSSASPSSAMHVDAVNPADPADPRSTASAVPSRRRKDEQRTPPSPRSVQPTPVTGAAAAVDGGGLDAHKRTRLDHPAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNX0</accession>
    <name>W3VNX0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNX0"/>
    <dbReference type="HOGENOM" id="CLU_011126_0_0_1"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000630">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.23, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="231"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="490"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="817" mass="89623" checksum="DFD43B1561C6B3BA" modified="2014-03-19" version="1">MSRTADSSPRGSNSPSPYPYPHTNPMHDAAAAAAVAASPPTAGPSTRRTIVDTLMHDRSDSPASFSAPRAPPSPSSTSQSDDGNPQQDFADLASIDDADSRANSNARAFDPAAVRLSRRGTLIPASPTSSNGTWILQDAPLNHASNLPHEILLHIFKYLVLYPPDLLSCLLVCKSWCLNGVELLWHRPALYKISSLFKLVGVIRKPEQLFPYADFVRRLNFTLLANQLEDQLFLMMAACTRLERLTLAGCSNITDATLVKVFQCTPHLVAIDLTDVADITDATLLTLAANCPKAQGVNLTGCKKITSHGVAQLATACRLLRRVKLCGCDNIDDEALMALTQHCPALLEVDLIHCPKVSDRSMREVWMRSFQMRELRLSHCTELTDNAFPSARGTTGVPMLGTSHSAGSRSAMVASAYAPDSAPTSRGVSPGADGRRGDAGLTRTLTAPSMSIAGDLAHGRLFDHLRILDLTSCLSISDDAVEGIVANVPRLKNLALTKCTRLTDEALYSIAKLGKNLHYLHLGHVSNITDRAVTHLARSCTRLRYIDVACCPNLTDLSVTEIANNMPKLRRIGLVKVINLTDQAIYGLVDRYNSLERIHLSYCENVSVPAIFCVLQRLTRLTHLSLTGVPAFRRAELQAMCRPPPKDFNEHQRQAFCVYSGKGVHDLRKFLQHVYSDEQLAAEFGQLEPRARNALTGLTLENAAGQDARLGQLRVVAQPEARRVQLSPAEQMYYEQHRELARYANARRATEDATLLNRPRSTEDQRALVDAQHERNPGLPLVAPQRDVQLPDIQTSLPDEPMDTEALRARRAAHFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNY3</accession>
    <name>W3VNY3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNY3"/>
    <dbReference type="HOGENOM" id="CLU_330679_0_0_1"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="750"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="905" mass="98784" checksum="19DC4F33813179C5" modified="2014-03-19" version="1">MRADRSVSAAAPRKRPLARRSCLKCREKKARCELPDVYVDSAKTPLPAEKRCHRCNVLGIDCVVWDGDRKRKPRLERLAESPASSSADQETATSSHSSQRRPLSDGQSPNPTGRLDRASDTSSSKSSKSPFAAATRVAAPQNIDIEQLGASDVMRDQRLLLGSQKGWRTVSKNLLTLIGRLDSSEKYSRYLSLRIDAPPSTPDILAFLHPDKAARLEGELQVYLVGHPYLPSLSQLHSEQSQNPTRPRALLLATMTLLGLKGFEDGLGSTDIRALSNYVDRLGTQMLLSSPRDIHLVMAFELLISHEPGLVGTAASQFEPQGRGLGLASENLLTCAIQIAKELGLDHAHIDQPDPASMLTEVSLWSCLRVWESLFCLIAKRARFPDGLDAKLASEIREVLHSVDDHAKKLPELPGLQDSLGSASTLHYNVRAYAAQMERRMGKDGVLRSAGRTVICLRMQAFCLLTASVRQVEEVLSDPDLELHEKQTCISDLYASNTSAILAIRDGDCQLGKSEVHSAQCMSRRCLLTQEHASMPLSQGVYSEQRIVRLWEQLLHIECSYACTVFSRYCTSALYTGKLNGHVEVEDMICSIRDRLHQDKPGVMELVSKMGRSGVDLSHDVLASISHLDRQPALRKRTAAGGNASGYLHQMPALLVSALAVDTARSSFESMAFVFVTWGGAPSYFATALTLIEAAAGRVSKLASQSSQNDVETVSEVASEYLLEMVNTAQVWQLYYRVYRPFRRPVATGATASTAEEQQQMPNPTHGPYRHQRQQAVEVQMETATPSGSSTQTSVAPLPTRSHRAGPQRSTGARSPFAVHGAAEESVDDAVPCSSAFPTADALLHDGEALSSKSEDTSALLALPASISAAVPLSNLMYSTQSNASMDAGIPFDLEAFLRDIDQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP38</accession>
    <name>W3VP38_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP38"/>
    <dbReference type="HOGENOM" id="CLU_073651_0_0_1"/>
    <dbReference type="OrthoDB" id="2545108at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="189" mass="20547" checksum="A910CBBDA0A31589" modified="2014-03-19" version="1">MTGSETARAVLFVSLAILGCLIRTYIRTANGEKEDEVHFWSSRFSQLAEAQPSPPPAAPVGQVRPRSTTTSSGEVSQAVSVLHDQPPRFAPFLADTVEPQPAEQVQSAPVACQGTEIDEAYEDWAAMHHARGAVSEDAEASIDKLWQRRQLQKAMGVHALPHLEPLGTSGANTPTIWTSHFPPAQLRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP77</accession>
    <name>W3VP77_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP77"/>
    <dbReference type="HOGENOM" id="CLU_900540_0_0_1"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="163"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="309" mass="33609" checksum="8983CBC43792A4B2" modified="2014-03-19" version="1">MALRRGKDRVANAGSEELQLWYAVRQNLRTLEKIRIASVDKAAAAESHRTDLIALREKKDTGDEYRTKRRKLDDVCHDLTSRTKDELAAIESAQEKLGILVALRSSADGAGSRSSTPRKDLASKLKSGGAGASTPTGRRGGPLGPSNLGTSSTNRGRRETLTAQHPLTPGRKVAVLPTKTEESDWLKASVLSFSKSSNEYSVQDDDEPGPEGTYKVGMQNIIPLPISLQTLPASDFTPGTRVLGMYPDTSCFYGAFVRSGGPGLTRNANLVKLAKREAELLETKYNLEFDDDNGEIRQVPAWLVVQEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPH3</accession>
    <name>W3VPH3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_246452_0_0_1"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="254"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="690"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="807"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="910"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1165"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1395"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1489"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="852"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="938"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="978"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1026"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1067"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1123"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1173"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1507"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1539" mass="162461" checksum="01FA04D56FCBC5F3" modified="2014-03-19" version="1">MTTESMSQGDPATIPSAATPCEAAQPSLDHPAPTETSPRRSGEPVASPPYSAMNLALAGHASAGAAAPSLSDADPTSSSVNASMLPPAQLYSSPAMPSDSKDLAQPVLIGSSPETTTHPTTHATASSALLSVDDAASRSASASPSVVSGSSTPARSAINELQLYAQQIQQQLLNQHIHRQLNAATPSATSSSHPPPQTQLASTSVSTYNSPPESGRSSPNPHASIRSNRPPHVLETHRLDIQTHTSGRRMVNQYLIEGELGRGVHGKVRLATDLETGERVAVKIVEREARKRLGAGLGLLGRNNRNREMLRSSSLHVDPTPGPSRAIDQVNTQATSKDATPETDSPQDDTTSVSTTVRGVPSTPSTQFAPLPHLPRSPSASALGIHSKRAQPDSDADRRREKERERARKALMWTTDQKVRREIAIMKKCSHDNVVQLKEVIDDPQSKKIFMVLEYMEGGEIVWKDDQAQPTLTVDEARSILRDVVCGLEYLHYQGIIHRDIKPANLLWDKDRRVKISDFGVSHFSYAMMIANEQSAAAPAATAGSSSASSSSSRLALPTGSTSDPSLVDDRELAKTAGSPAFFAPELCMSSFSSASPSIDPRHDAKGASLADAAEAKQSSAAAARPKVTKAIDVWALGVTLYCLLFGATPFTAESEYALFSVIPTTDYSLPVSMGADRVRVGPRKPRWRSHVQWTDEEADAQPQSPSDLIPDADPQDLSEDARQLRDLLDRLLEKDPAKRITLEEVKKHPWITHGLQDAPAWLSETDPHHHPFVEISHADVEDALTGFSKLKQRVKRWQSKLLDSFSGGRRRSKSVNHSSAGSSVYADIHTDSGSSSPRPNRLAMPEDAGSTPVTPFDSSSHSGSSARTPRTPLKGHIFFSRQKSAGSVGRRDGTTTLRALTTTVRNDEDGDAIALGSPRTTLAGTTGKVESKALSGQPASPSLSKEDSVQSSSAAHMLPPLVLTGRLEGDTMRPPSLVSQRRVSAHSTSSIGARSDAAPEIPQRTSSGTHALASKGGAAPVSPVLLSQSPQTTSLQRMLSRQGRTSNDSHPHRAASPRRSADSEGRSSTLSISQTSRVSGRHRLGDFLRGSWLMTSEDRHRSTSRPSTRGSREAAPFGLGAAGSSTVGRSGSVRSNASSSRREAAAGPPTSIALVVDTHGAVRQTGALPGSGTPTSAPVLGSNSSSALTGAPSLSTELLSEPVESGSIARSAFGAASQPTSPLTGLEEAPPFAFDRLGRRRPIQMALDEPDNDDVDLELEFSDDDLSDDLHGVSAGPMLVNAGHGWSVRDSDHLGGGGVNGDGVDGPTFLPEAYRRKTSGGSDSSHDILTPSVEGGYNVFKPPYQHLLSPPEVSEAPGQHAVPVAAAHFDDVAAAPSSQAFAIDVGLSPEAQALRKAEGTETTADALVDSSARPPSDDATPISSGSVSRSASHRLQGSDDSSRAPSAAGTYATGGSENEVHLADVLEKKALEMPSAAIKPIIATEESQFADADEDAAASATPAALLDDDDDDSDEQCVSFQARRKRSTRFRPAAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPL3</accession>
    <name>W3VPL3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242228_0_0_1"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1330"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="666"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="857"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1405"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="886"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="951"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="970"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1053"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1172"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1196"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1244"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1421"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1540" mass="160490" checksum="8CDB8E9315CE6DA6" modified="2014-03-19" version="1">MSTEPSSGHHAQSSSTSGQNDSSDLNFTSSSSSGPAVQPPQPAAQSTFQWPSEPLNHGRPSLPQESQKSVDDANRDISQRITDADHDANLHPAHNTPHPDLDHPRLSAQLAHALNNIEDDRRQQLSPTSTSFLPDNSTSLPMLSPQPQAMLRSTSNSTSKSAASDKLDPSSAAPSAAQYNFLPEMFRNAATMPINLLRSLIPDNAFSAANDEGLSASTLQVPVTSFSALFEACKALEWLATQAANFEAPDKSSASRSRRNSTGQLQSDDNVEFTYFDYFQVLQKVADVVSGLAASRGIDLVLDLDPKLEGQPAENQRNYKLGSCTVWADRIAVTFLFMSCISRLLHKAPLHSSVVITTTLTEKEETVPRPDAQAEMKLMVLSLGLRLILSDGSSPSTEYVSAIRDTPASLLLDAFGARLITEQSTIKTASGAQQSVVDHSISVPIGQLSDPQQGAGSKHPSDASAHDIVGPDESELVDFAASLKGKKVALYSSSQSLFARQLSTFLSGLGCDIAPVFSDSVDESSLEGGDQVFGKQAHTAVAMTAGRPALVSYTSDMDRRAHSNQPQSPRMPSQPVVGTTATPAAVSASTVVLDPVTGVPITFDRPVLPPNATSAKDDSDAHKHPDQLDRRVVPFSFVIIDDDIVTLQKELLRIRSAVPLLKSALVSKTAQQPTSPNDDKRPARPVLDHRTKSTPHVNRLMASQPAESHSRSFGSLGSMLMSGDKVEAADIGDSAADADTAVAADCVSQTIVFFTSMKSYRLVRDTVQPIIDSASFHGVSSPPEIMVLPKPAGAKRILTALHLAERKPVVKLPFLPIATSPLSPLTTYAKSWWTPDASQKGDANGIMTLTRRVTTSTDADFDTMPSTPWTPVDASKPSDAPATPQIPLTSETLPLAGQSAQSAGAHTTHSAETTKQPVRGAPASTPAAPTTAKTTPLSAASHKSGKNGVLSTAPAAADATSTQKSAHPGSAAANSSSPSSAANPTRSLPVNSPMPADALEYFSETAAKMGGSAASGMVIQSPDGRPAGIFFQPKGMQSNTSLPGSKPALSRGVSASSLRRSIPSTSEHGDSAGQGVSPASAESGTRERRLTGRSTASSAGSARGGGEPGPRGALPILSESLADSTPADASAAGGRVQSNGKYASGSMFAPQVGIQSVMNSSRPPVTTPLGTSASSASQDPAAASESASLPAVTEESVATRTDSANADTAAQRAGSAGATKGKAKEASPSTSAIARKPTKPATPPTKTTATSAGAATALPPKARTASAAAAVRAARPSVGSATASPSDARTKPSAVAQSGFMMGMGFTASARRGRGPKKAPVREAVLPPIKVLIVEDNPINQRILSMFMRKKSIKYDVANNGREAVDKWNTGGYHLILMDIQLPVMDGIEATKEIRKLERQANIGILPNTPPAVPESRVHKSASPPSKSAGGSRTIASKAADNADGSTANGVVETNVGAGVVRRTGSTNPFRASVIIVALTASVLSSDRVEALAAGCNDFLNKPVSLPWLNQKILEWGSMMYLMYSGLSTDDVRSRPGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ32</accession>
    <name>W3VQ32_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ32"/>
    <dbReference type="HOGENOM" id="CLU_1272769_0_0_1"/>
    <dbReference type="OrthoDB" id="18703at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="217" mass="23561" checksum="DF8D1B0654A23DE4" modified="2014-03-19" version="1">MVRADQGIRGRSAPRSKNRSSVTSTIRARSAGTDAANVAAPPPTQITKAAKRAMKRAELMSKVNPAGKASLLNLKPKNSALSKSSLRRQKRKQKEQLAGNTTGLKDLAEAMDEVAQQFEDDESAEELDDGEDEDDDVGAYSARSGRPSSTHPLMGAQRSRKDATVTEKARKAALSVEMQRQNLILSDPAYTKSPFAALRLHAQNTLAFDKRSNKRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQF1</accession>
    <name>W3VQF1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQF1"/>
    <dbReference type="HOGENOM" id="CLU_063733_0_0_1"/>
    <dbReference type="OrthoDB" id="2545226at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30111" checksum="06EC9A41FE51317C" modified="2014-03-19" version="1">MASAPRVIFRGPPGMRKAIYYFIGSVFTGAGAYQGYLLTQHLSWPLLSRDVENTKLAPPMLRYATGAGVGLTAGALGMFFFYTPSRLATRVTLYPALRQVGIRTAARPFRSFLPASMRSKKSAPLNPKDPYERLHNLSALYRRDRTSAVEIEEYAQGKGIRVVSATSGKRQKVPSSILLGEDVTLGYQLEAAPTPMFETKAKNLYRQYWSRFRLSLRGDTDWSKVAGGHALSDAELTARQQLSPKDPWFLDRRNFDRLFPVRSYKSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQK1</accession>
    <name>W3VQK1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_02267</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQK1"/>
    <dbReference type="HOGENOM" id="CLU_041805_0_0_1"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833480" description="Alpha-L-arabinofuranosidase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS63938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="332" mass="35873" checksum="438E99A25993F278" modified="2014-03-19" version="1">MKISSSLVAISVALAATLVGASPTAERRQTCALPTSYKWIPSAPLAQPANGWVALKDFTHVPYNGKHLVYASTHDQGTKYGSMGFAPFSTWADMATATQTAMKTSAVAPTIFYFSPKKTWILASQWGVASFFYMTSSDPTNPNGWSEEKPLFTGKIADSDTGPIDQTLIGDSSKMCLFFAGDNGKIYRSCMPIGNFPGSFGTASEVVMSDTKAKLFEAVQVYTLEGQNKYLMIVEAIGSGGRYFRSFTADSLEGKWTVNAGDESAPFAGKANSGASWTDDVSHGDLIRSNPDQTMTVDPCRLQLLYQGRDKSVATPSYDLAPYRPGLLTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQM3</accession>
    <name>W3VQM3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQM3"/>
    <dbReference type="HOGENOM" id="CLU_002738_3_1_1"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="10">
        <location>
            <begin position="317"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="429"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="588" mass="65277" checksum="1254A8C1708184BA" modified="2014-03-19" version="1">MSDTQDAHTKDGKSAPSVLTSKFAKLNPFSKTGSADPEGGGDNLGEEVEFDSIGGGGHAARRTKITKSELRVSHALRQFLVDEKLLSPVDAALDDQEASSSEALKALVDQSHIDVPDYVRDRSRPLSEYFISSSHNTYLLAHQLYGSSSAVAYEHVMITGARCVEIDAWDNDDNPTEPKVTHGYTLASHIPFRAVCETMKQALRKEEEEAQRDSSFRPAPVLLSLENHCGHAGQKRLVEIMHEVWGDLLISGPVDKGVPASEHTALDHLGAKIAVMVEFHPSDKPPVEHVDEDDDDEERKNKAKRNEAKKAGIIPELCALGVYAQSVKPTNDSWYTSTLTNGPHDHLINISETGLLDLLPKQAAGIKKHNAQHLMRVYPKGTRISSKNLNPVPFWGVGAQVCALNWQTFDHSVQLNEALFSGSDGYVLKPAGLRIGGDGNTALGRRRLKLHIAGATDLPIPHGHDADDIRPYVTCTLILPTDLENEPQKEKTKPYKQHKLGIIHRGEQPRPTDPLWNETLEWEFEHDELAFLRILIKSDDKFARNPLFAVAAVRLVYAAQGWKFIRLLDLKGRETHSTLLVRFEWENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQY8</accession>
    <name>W3VQY8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQY8"/>
    <dbReference type="HOGENOM" id="CLU_019845_2_0_1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="394" mass="41286" checksum="724F2A4929B5DA0B" modified="2014-03-19" version="1">MSSSSLQNVVVVGAAASGLTTAQSLAKSLPDTHRVVLIEANPVAYWSIAALRGSVLPGFEDQVVHKLSTKTVFGAGSRHIVLTGTRVVELGSDHVVVSRDVTSEVSGSTLDVEGRTKILLDRAVLGLGSDYGFPTRAATTDKSADDIKSHFVKMQNDIKNAQDILVIGGGPTGVEFVGEVLDVHPNKKITLLTRGGALASTGDDAFVGMSKKLLSQLQAKGVRVILDDSIPKDLTTGPIDPTSFTTKKGVELTADYVMVALGGRPNTEWVKSSHPELVDSKGYLKVTDAFVLDAPGWERYYSLGDAANTPGLKTNYIATQHASLVAHNVVAAIKGTSADKLKRVNGAPGALMVVPIGKGGGAGYLGFATVGSWITSFAKGKTLFVSKFHGSFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR04</accession>
    <name>W3VR04_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR04"/>
    <dbReference type="HOGENOM" id="CLU_068308_0_0_1"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="14"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="285" mass="30897" checksum="B1A75D4A133ACADA" modified="2014-03-19" version="1">MTWPTTTIFDAVFIPLYAIVGVLNLVNVVRHGRGRTVGFISLLIFSLVHLAGNILLVAEYKANYASIDVTVWGYILQSVGLSFLVSASIAFYTRARGLLHEDDKADRITKLLNLVNLAALICIITGYTSTDFTNAQGEVINPKLPVQCKIGALLYVGLIVVMALMAAVRLASASIGEAKLIKLSLLVAMTFMLVRAAYSVYATFKGSILVPNNVWVKLVLQYMAEFLALATYTALGFLLDRTAKTAHFHIEDGAGISPGTDYSSTDGLHKVPITYGQPRIPPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR22</accession>
    <name>W3VR22_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_02254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR22"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_3_1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="583" mass="62480" checksum="168C87E5D4241E5C" modified="2014-03-19" version="1">MARSNGTVDERSALLTSHKDNSATSSYRSTSDNRDNDGVDSSSLSSSPTENDNGGEEDHVKVMPPLSKLAPLLTALWVPVFVASMDGTVTATLISSISSSFNASEQAQWLGSAYLLSVACFTPLYGRMADIIGRKNCMYTALTFFTTGTLLCGLSTSMNMLIFARALAGMGGGGLTTTTSIVLSDLVPLKQRGLLQGLTNIVFGLGSGLGGPIGGWMNDTLGWRRAFLIQIPLLLTDYVLAFVFVNVKTPNSLAHQSKWDKLKSIDFFGAFSLVLGLSSTLIALSLMSANDLAISHPAVWGGFLVGLASIVFFFYAEARIARNPILPLRLITQRSGAAVAFANFCLSIVSFGTLYHFPLFFQAVKLETPSLAGLHLIPNSVALSIGSVLAGIVMRNSGRYYTYNLVNSMLITVSIVCFALMSQHSSEAFTYISIIPHGFGTAGVLTCTLIALINSVPRSDVAVATSMSYMARNTGQILGVSGGGTLFQALLKRQLRQRITGKDADRIISEIRHKTSIVPELPKELQKAAVESYAYALRWVFIGIALVSVGTVIGCAFIEDRELPSYESAKPASDDQEENRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR27</accession>
    <name>W3VR27_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR27"/>
    <dbReference type="HOGENOM" id="CLU_030508_0_2_1"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833195" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="54190" checksum="9843D54B70E70D0B" modified="2014-03-19" version="1">MRHRPLAAVLLLCSLTFSLALYLRFRSYDLVSVGLCRVAPLSSSCSSAAMPVSPAELDTHRVHTGLNGGKRGRVSLSIGSLNIRYSRNAAYDSTQSMLSSIENLITAARKGAGPASHHVFSEGSPYLMQQYHGERSWLLRGPKVADVALFNDWDLFAFQEVLDGQLGNLVHWLGEGYDHAGVGRDDGHRAGEAVPVFWRRDTFERVGQDQGGVGKDGVEHFWLSPTPSKVGSVGWDAALTRMCTHVSLRLRATHEIIHVYSTHYDHQGIVARAKSSELIVERARRASASTRAFYQAKSSALALEEPLVVLIGDLNSPRNEGSWSTLVSAHYGIPANSSGASFLDTALSVPTRFVSPLLTDNEDPHRAILASGRKLPSSPGDSGRGGLLSEPVGPLRTFTDFQPSPRNAIDDRIDFIMLLDNAAVVDETHPHTRLDHSPSPPPAGAMRRSEAGQSDKASRWAIRTFGTLPNWSEGDAGFLISDHRPITARIQRSFPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR58</accession>
    <name>W3VR58_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MATE efflux family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_03028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR58"/>
    <dbReference type="HOGENOM" id="CLU_019477_0_0_1"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="762"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="82958" checksum="6835C4A8C4D06E13" modified="2014-03-19" version="1">MSFTPRYGSSVTRDYTLLQGHPSSYHHFGALGGALTAGQSRAAHNDEADAQSVSEDHDADDTDAAASVSSIHQDDSTDTGLSNISLPTNHLTVASSPAFGRGNRLASTPAPIISPRNRRPSVNAYPQVAGIPSEYLLGGSAVPPTHHAGGAASNLSLGAPAVPPLSPAAPHKPPRRTDNDNAEQNDDDTDASESTALLHHNRSSHQLPGSSAAPSSYGAVRRSSFDGASIISGGPGVSGWAAANLMREAPLPGVEQIEAIALESHDHVAWREARVLIGYTIPIFATHILELSLSVASVFSLGHLGTVELAAASLSSMTANVSGYSVLSGFISALDTLLPSAYTQQPKSVGLWTQRMGVILIGILPIILAIWLNAEVILIHIGQDPEVAYLAGRYLAVLAYGLPGYALFEVCRRYLQAQGLMHAPTIVLIFVSPLNAIANYLLVWGPDSIRLGFIGAPIASAVSMWLMAVLCFFQCVLAPRDAWDGFTTAAFKWDGIRPVLYLGFAGMVSLAAEWWAWEIVGLVTSQLGVVALAAQSVLLVSSSVTYQLPFGASVATAVRIGNLLGANRPEEAKISSRVALILSLAMGGLNSALFLIFRKQWGWLFSSDIEVIKLVEYILPLLAFFQVADGICGIAGGVLRGTGRQAAGAGINMVSYYIIGIPVGLVLTFTRINLGLAGLWWGLTIALLFGSAGMIWLIGITDWDWEVKKVQLRMAVDDPSDPALNAAVSTPQGAAKPDVEAASHPRLAQTTSAVEAINSRDPALSPLGMRPSSIAGSVIEEEDEVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR99</accession>
    <name>W3VR99_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR99"/>
    <dbReference type="HOGENOM" id="CLU_2224346_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="106" mass="11532" checksum="D3E9C1D1079B4E3C" modified="2014-03-19" version="1">MDPDQLHTNTSCQLLPDPRSVIYLHPLTVASVTTASDDTWTQITARLGRSETEAGSARVQAEGCAAGRSDGQPQAAMRQRSEGGASPNGTRHPARRRMKVFRVSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRK1</accession>
    <name>W3VRK1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRK1"/>
    <dbReference type="HOGENOM" id="CLU_006275_0_0_1"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1223" mass="133337" checksum="D5461CB9E3888ED7" modified="2014-03-19" version="1">MSESSSKPTINTRMPKGAKRPKTSRACLACRKLKARCEPAGGTKAAPSDDPQPSSLSFVICHRCKTLCIDCLYETPAGEVVKGEDVQPAISSPSPAEEHNRAPRSSKRSRPEDAPSSDPFSNDRAVFLSPAISPSSLTRSIYRDVDICSLNTLQPAYLERPVLPANALSRLIGANPALKRDAQDYILNLSGAFGSGSTHSWKQAPPDLCAGKAAARLMAGHAPLPAYPHDELEYLGRILQPHEHQLRILFHGLYGAFSPFLSTPFEDSLVLSNAQSEAQSFVLLTIYLAAFPHLEASQPIAQAKAPLRKAIDALLRRAIQSPQSDHLNIFALHNCATFLLLPVDGLAENCRPISTPEQEVDGLLEFAPDLNPRATIITALIVAQRLGYASLAARLPSLRQSFDVDSPQNGYSGDPTRDEYAHAVLCTFTWLTLLQFRASIDVAEDRVEWDSLAQFERDIPRVRIDAMTAALQPPPAFLSPREQSRCCWMAQRAELYGIARDHRHTKRAAASFTKKEAEDQAMGYKKALDEWRYKFGEQMRSMSTEFRKDPRGLGLHRFYSIFSNAEAASLQVAIGSVYHKEFVADMRQRLAEPFFSDGLPWKSAATILLGHEEDQLTKAILINFAFTDAMLKAMGLISSLTPVMPQLYDFVSYEESAGSEIPSLCIVAPPNLQAGLFAVPLLAAADLRLSVIETWGASASYFNHHVMPLLTNCVKSLRACHVNVDLPGVLKIPFATANPIADYLQGPFEILMRKVASAEERLQISHVESILNNSFLLSSKKKQIETVAEELAPDVPEMVQAIADSKKIEDEISAAMMGALNVQSIREIQDTDFAVKVFGSDLREGDVKAIRKPGRNGSSSATTPDAENHRRGPSNARSSSVESEQTGSPSVLTHSSKQRTPMHRSVRSVANASQYSSPSSSTQSGNAAPPDSAVVYHKDPAVPPQGLEQTPAMGYAHPPTAYEASVLQPPSQPHEQALASSYAPISQTTHAGPTYAPAYAERSIDAPHGYSGSASGVHGMDAYASYPNERYPAESVLGLEAGHAGAAGTAGTGSADVYAYRSDGDHVSAPMHAAGYDGMQRQGAKAEGAGYEGYANVPQEQPQVSEPWQQQQHTQQPQGYGGAYGGDAASSQAYYGQQVSEQQYAEPYAPVYDQAHYQVGQGQHPVAQGQHGSTIWDAWNWTPGQDQPPHHQHPHQQHGHHQQQHQPHPHQQGQHHHQQQYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRM9</accession>
    <name>W3VRM9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="15">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_01386</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="15"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRM9"/>
    <dbReference type="HOGENOM" id="CLU_003827_9_1_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000069">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="4 14 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="96"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS64150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="350" mass="37518" checksum="8195B1D347909222" modified="2014-03-19" version="1">MLIRPVLSSSLGQAARSSLRSKAPAVRQYATEAGKPSGGSNLPLVLALGGVAGLGAWYSLGGFDDPKKAKNKVQEKGQEAVDQAKAAVSGGALNKDQFVEFTLKEIKPYNHDSATLVFELPDGKKPGMNVASAVVVKAVGEGLKDDKGKDVIRPYTPITSPETEGHMDFLVKKYPGGLMTTHMHSMKPGDKLGIKGPIAKFPYKANEFESIGLIAGGSGITPMWQVMQAIASNPEDKTQVTLIYTNKSEKDILLREQFDQLAKTDKRFTVVYGLDKLPKGFNGFEGYVTPELITKHLPKPEQAGKAKIFVCGPPPQVEAISGGKGPKGSQGELKGLLAQMGYTPEQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRS9</accession>
    <name>W3VRS9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRS9"/>
    <dbReference type="HOGENOM" id="CLU_148180_0_0_1"/>
    <dbReference type="OrthoDB" id="2555115at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="147" mass="15717" checksum="5BF6E865FA0B6D76" modified="2014-03-19" version="1">MPHACSSSARKVVRLPTSLNHLASRPPPPPLHLPSPFATMSLLRTSAPVFSAVRAAAARRTLMTSTVRRTDDPRVLNKDTHSGASVKADKHDKDPKTLQKETAQAANQSGSTSSSGAPTNSEDAVHGEKHSKSPDQLQKETAQKHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRT5</accession>
    <name>W3VRT5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRT5"/>
    <dbReference type="HOGENOM" id="CLU_028488_0_0_1"/>
    <dbReference type="OrthoDB" id="2555377at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="611" mass="65875" checksum="312D546A18592FB5" modified="2014-03-19" version="1">MLQSNTDARSFKLQPAPRPKCKKRPQSCTSPPTPAAASTAFPIVDTSSDTRSLRSSFDDDDAPTPRASQFASPLSPRSSMSAASVASIRSSNSVARLLASLSVSPRLKTSPVATVPVVLTSQSPTPSSPLFPRRTLMRSLSATCMNAQLKSPTSPMTPSVDAKMRKRMGWRGALSARMQAETAILLSPGSPITPRRAEALHTPTQSSMARDATEAEIEPLSATLKRLGAKRRTERFASTCVPVQSPLQEEMYKSPDTASSESWQVMTATRKILQLPSWVRFEANHHARTRAAADNRAAAAEYSKLQLERSAAQEADAMLPKVSHVGDVAPDSPNGELFAGFDVDLGAEKKQEPEWVVSVIRPPNMAALRTDKVEAKGSRVLGAVRSALPGLAPQRRIKDYIPQDERDGWGGVTRSSWFRGYDKGPLVSPNPPAKQRGLKRIILQPARGEDEWEDIDEPCSAKPAPTSFLEMNDAPRFQPRVAASRWFPFRPSGAKVKDGKDWMGDIQLDTWRTKRLAVDKVASELVTKHGSVENRPVRGRSARTAGIVAALTAVLVVAIVAIVMTAKDTPVQMMGGGGASVANGIGPPTAVQPVLDPRQSSVAKAAHMSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRW9</accession>
    <name>W3VRW9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_01841</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRW9"/>
    <dbReference type="HOGENOM" id="CLU_031067_0_0_1"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16451">
        <property type="entry name" value="mRING_PEX12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="31"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS63546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="430" mass="48213" checksum="381798626298ECD8" modified="2014-03-19" version="1">MDVLTSIDPTSSQPSSADPFHPSFFELAAQAQLQDLIKPAVRYVLAVLAQRSPRYLLRVVNSFDELYALLMGGIELHYLRVWGSSFAENFYGLRRRRRPGLSRGSAGVGATSVTVANAERLRKSEIRLSLLFLVGLPYIGAKLEDVWERNGGGLTNTAALFDDQPNVARFNDAPASLRERIKAAVMETFKTTYPYAKTAWQLWLLTYNVRYLFDKTPYWRPWFSLMRIDVRRVGPNDGPRKPLVPRKFPSLIRQPARFFAMLLRLAPGVGFEALKYGLPASIFFFKFLEWWYGADNPRRRRNTPSVNEQGSAQSLDPPAPLLPDPKGLLAEAGQEVEYKLPHIFTLSGKLLDELDNGADAKPTLTKGGRKLIHNSCPLCGAMPINNPAVLPSGYVFCYTCAFNYVQTHARCPLTSISIPDRTDALRKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRZ4</accession>
    <name>W3VRZ4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRZ4"/>
    <dbReference type="HOGENOM" id="CLU_022986_3_1_1"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="101"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="478" mass="53094" checksum="7A7A7293A7EFC6D8" modified="2014-03-19" version="1">MLSTHYHQRWLEDSPSNKQQRQQRRLRSWTSGGTMLALTRGVGVGARASERSVAAVVRHEGRCIATAASGSGSVAPQAYVSRSTNPWFNLAFEDHLFRTVDPAVPVCFLYRNASCVVVGRNQNPWKELNAAAMRSIDLPMVRRRSGGGTVYHDLGNTNYSFHMPRDSFDRRTHAELVARALNATPVGLHLSRSSLARADRGAYVNARNDICIRVQPRFDRSATEKTRAEADEQGCEERKVSGSAYKLVNTRAYHHGTMLLSASLGSLGSSLRNERGELLVTKGVASVPAPVANLSEAFADRRHMLTHDVFVHAVVAEFLRTHSAKPGTHIEVDESSLAEPTRNEGRWKLQENFDELQSWEWVFGQTPEFTHRVALHQPAELEAHGVEKDGWGPFAVEIHSKHGIVLDAKLADARFEQERTEDEVRSVVHALKGRRYDELALPPPWGPTSSPPAAADSIEGGTRATIRDALLAWLRTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS86</accession>
    <name>W3VS86_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS86"/>
    <dbReference type="HOGENOM" id="CLU_035888_1_0_1"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="450" mass="50273" checksum="04E09970E16B524A" modified="2014-03-19" version="1">MAPTRTKASSIGQPSQPAQSSRKGKKAWRKNIDLTSTEAFLEEQSDPLRQTASDALFVEDRSGQETLTARQARGKRPLKSLEILQRNFGHAAVAPAKKQKQAVGVDKRMEQRLRKMVGRQQVGTQGDASAIVDRSANVVNKTLGDVYDVWGSSSGDAKGKAKADDWIPTAVAKPAVHVPKTLRRDDFDVASKLPAVELPHPGSSYNPDLESHEALINEAYEIEKRLEENEQMDQAERTAWQSKLATIVAREAELRAQKDDDLKRYRGMDVDVPGLGSDDEAAAEDDLDDASSDDEGAESAEPKRKTRQQRLRAKRARMQQLEAARRKQARIEAAAILQLPALKRRQARLAAARAQAAEARKLEKTALLERKGLAGHKVGKHKVPQQQLDVQTPDELADSLRTLKPEGNLFRDRYTRLQSRGVIEPRVKQTPKRRTHKIKAYETHDYKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSA1</accession>
    <name>W3VSA1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSA1"/>
    <dbReference type="HOGENOM" id="CLU_112099_0_0_1"/>
    <dbReference type="OrthoDB" id="10345381at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833553" evidence="1">
        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="202" mass="22722" checksum="84B7CCAA314747EC" modified="2014-03-19" version="1">MTSRVLSRVIFLLYALTLLCFCRHALAPRSEDIGQRRQLRAPADLAGRRAVRRYLDIADDASSAPNPAFYPGTPVPVDVMTHLLGERYSVDHHVPIPVVEGQESNFYSKVRELLHHPETPVTSMGWEGNTFFLAQARRLDYSNYPVWGTMIRPPFQLHSDAFHPIFIGKVLHNNPQGHEFDLLAVRSPATNQSALGARPAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSH3</accession>
    <name>W3VSH3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSH3"/>
    <dbReference type="HOGENOM" id="CLU_055188_5_1_1"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000011">
        <property type="entry name" value="50S ribosomal subunit protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="135"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="280" mass="29823" checksum="A07B47E700C13DB8" modified="2014-03-19" version="1">MSAASLARSFARLALASGSRTATLAPSARLVVPRLAQSALLKNSTPSSFRTYAVPASGSIRLGNLQPGQPTKTRKRLGRGPSSGRGGTSTRGHKGQKARAGNGKPVPGFAGGQTPLTRLYPKRGFNNVHGQTYVPVNLDKIQHWIDRGLLDPSRPITAKELYETRCIHSLKDGVKILGEGAAHLESPLNLVVSRASQSAIAAIEAKGGSVECRYYTPLSLRALVKPHKFAGKILPRPADPIAKKDLVWYSSPRNRGYLAKRAALAKALSQQQPATSEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSM1</accession>
    <name>W3VSM1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 88 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSM1"/>
    <dbReference type="HOGENOM" id="CLU_027158_2_0_1"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="429" mass="48173" checksum="C26A7D2EE52CD081" modified="2014-03-19" version="1">MITATPTSAIPNVSRPEGSQRADIDLPATGDLTFCAAYLLAVTNTAKIWAVAQRELDKPEPPTSMPEYTLPGESRYQSTPASFWTSGFFPGSLYLIYERQRRWPSRTIQKPDIASLQRACKWWTEALHEQAHQKGTHDLGFLIQPWAQLAWELDEDVKSRDSLLVAARGLADRFEERVGAIRSWDTCFTKRYAFADPSKDFLVIIDNLMNRRLAEIATEHALTTLKSHVRADNSTCHVVNFDQGTGEIKERITNQGYSDESCWSRGQAWGITGFAQVYGWTKDPRFLAVSKRLADYFLRRLPQDGVPSWDFDAPGPNKPRDTSAAMVAAYGLILLAEADPLQSRKYLASALRLVESVCRLSFSKPEARFVGVSPSGVPISDVGGHDTILLNATINNYEFAPRRWADHGLVYADYYFLRIGNKLLEMGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSP4</accession>
    <name>W3VSP4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GABA permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSP4"/>
    <dbReference type="HOGENOM" id="CLU_004495_2_3_1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="57119" checksum="DB5FB6A4CA17FFF7" modified="2014-03-19" version="1">MDKNNETYDDKPNSSVLDYHQTETLDQGAMAVVPRKHFSTLALIGLSFAILNSWTAASAAINLALGAGGPVGVVYGLLVGTICASTVALSLAELCHVFPSTGGQYHWAYAMAPKRVRAPVAYFAGWLGATGWVALGCSAPLYAASTVMGIISIYQPEYKPGVWLTFCIYLAASIYCVFVNLFGARILDAMNKAAIFWSLTGAVTVFVVCLAVPSAQGHRTPASVVFGQFVNLTGWPDGVAWMIGLIQAQYCLVGADGASHVIDEIDRPHINAPKAMVLSCLIGGTSAFLVLIAVLSGISNMDNVIAAGAAGIVEAFYQATQSKAATLVLNLILFGTIFFAGPALMLTSSRMIQAYANDGCLPFRSKLAYVSPRFEVPTYAVLFCFGCYVVFGVILFGSVIAVQAIVSASVVLLQISYVVPIAGMLFGGRKRIYGAQDQQDEEVPIPKDIKYSLGPVLGPVINSAALAYIAVTTVLFLFPSYIPVTSGSFMNYAVVVVATTIFLATINWFVFARKDYAGPRDFKEILERAHVQRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VST8</accession>
    <name>W3VST8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_02183</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VST8"/>
    <dbReference type="HOGENOM" id="CLU_135792_0_0_1"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS63861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="174" mass="18273" checksum="500987EFF2AFE578" modified="2014-03-19" version="1">MAARSSSIAGPGAGRQSMYPQANANMMFGGPSSSANQARLVSKQAELEGLRALKDQSAKMVKELERLAETVDQMADGGDSIASVMGSWQGVFRAIQIARASTVFTNPPTDTAEGAEDTSTEQEEDDLYNYGPAPNSKPALIDTMVRIPIDLDGAIARARDDATPDTSTTVSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSU1</accession>
    <name>W3VSU1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Myosin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PaG_01089</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSU1"/>
    <dbReference type="HOGENOM" id="CLU_000192_7_6_1"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="19">
        <location>
            <begin position="41"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="20">
        <location>
            <begin position="778"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="1066"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="16">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="971"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1123"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1228"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1015"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1232"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1251"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETS64619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1279" mass="139170" checksum="E4029F1C1C151815" modified="2014-03-19" version="1">MAISKKAGAKKAGAAASKPPPSKSGGVAKADWREGFKKAQAGVSDMTLLSKVTNEAINDNLQKRFQNAEIYTYIGNVLISVNPFRDLGIYSEAILQSYRGKNRLEMTPHVFAIAEGAYYNMNAYKENQCVIISGESGAGKTEAAKRIMQYIAAVSGGSNSGIQDVKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIMFNAQGEPIGANITNYLLEKNRVVQQIRDERNFHIFYQFTKAASAAHRENYGIQGPEAYAYTANSHCLDVSGIDDHADYRETISAMNTIGLSQDEQDNIFRMIAAILWIGNVQYVENEEGNAQIADAAVPDFVAYLLEVDAGNVNKALTQRIMETQRGGRRGSVYEVPLNPTQAAATRDALAKAIYNNMFDWIVDRINQSMKPRADSANVIGVLDIYGFEIFDNNSFEQLCINYVNEKLQQIFIELTLKKEQEEYAYEQIQWTPIKYFNNKIVCDLIEEKRPPGIFSALNDACATAHADPTAADNSFIQRTGMLSSNPHFDSRGTKFLIKHYAGDVMYNVQGMTDKNKDSLLKDILDLVDSSANSYLQKLFPDRPDPNSKKRPPTAGDRIKASANALVENLMRAQPSYIRTIKPNQNKSPTEYDTQAILHQIKYLGLQENIRVRRAGFAYRNTFEKMVERFYLLSPNTSYAGEYTWQGDARSGCERILTDTGIAREEWQMGVTKAFIKNPETLFALETMRDRYWHNMAMRIQRAYRNYLRYKEECARRIQRMWKNNKEGLAYIQLRDYGHQVLAGRKERRRFSLIGSRRFMGDYLDVGGSNGKGGGSAEGQMLRQASGMGAGESVAFSSRIQLLVSRLGRSSVRSPRFLILTDKAVYILVTQMINKQVQTTCERRINLGAISAVGLSNLRDDWVVLNVTNAEEADPVLHCHFKTELVTHLLQRTNGAVNVVISATLEFSKKKDKKAHITFKKDETVKKDDVYKSSTVSVCTGEPANSVSKPAPKKKPGLVRPITQGKLLRAGGPTNANNKPKPRAVPRATPAAAKLPSSGGAAKLPGSGGGGAVAAARSGPPPPPPPPPAAAPAEVPQVPRYKALYAFATDNAGEMALDKDDVVEVTQKDETGSGWWLVKKNGVEGWAPSNYLELIPQAPPKPKAAPAAPVKRAPPPAPAASSGASTPTSKPAVAAKPAFGGGAAAPVMQPKPVVRTTPAGAKPHERPTAVQPDAGAAPVAVMPGLGAPGGFAAVLAKKKAENAAAAAAKNGANGGGSGASTPPPVAAKPPVAPKPAANGRAMPPPPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSV9</accession>
    <name>W3VSV9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSV9"/>
    <dbReference type="HOGENOM" id="CLU_1256516_0_0_1"/>
    <dbReference type="OrthoDB" id="10408751at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="220" mass="23886" checksum="AB6DCF23DBEB8435" modified="2014-03-19" version="1">MSAACVDQEKSGVGQRQQSVVNTESAGQGSSIGSSRGIDEDEELSEDGKVMVVDQRRNALLVCRRTVKRLGAAQGQESTVDERRCSSVRKEDWPEEGPGAGADLGAIAQDAEEANESLERGGRGRGDDGVRSSALGGRDERAAAMGEKRQKRAHRTGREEQEEAPIKPVRTSQCQMLEMRREERCAGNGRQGIKERQRQGSMGVAMRPNVAARRGTHRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSW1</accession>
    <name>W3VSW1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor IIIC 90kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSW1"/>
    <dbReference type="HOGENOM" id="CLU_010810_0_0_1"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="64"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="736" mass="80390" checksum="94186549C0BCFA08" modified="2014-03-19" version="1">MPPPSHPTRSADKHAILKVLAMPDHPNGSSAGARRRSTDDDSHRIRTCSIPLSSGSSRIGNLEWSDLGQALVVTEDSIVVLSPLSPLNPALVPQSRAHDVECHPRWQGRFPHSLVQINVQTFLENEDSLRSRIILEADHSAVDPRFLNLQWTSATWSKPGMGPHGSCLILATTSELDLLVLGAPRNAWTGEWRLLHAVDLQPVAGLAQVDLPKSSSASSHAAGDRAIFTPSRALLRKKQMATEVLCAAFIDLPSSAPLLALSTYIIAGTRSGHLAVWECHASTGHCTFLTATAVSNTAIEQINLSVQAAALEADAQARIAFQDAGGIGLCDFYALEDHAVLQLAESPSVRSGHCMVTAWHWSKHCLLYATIGSIYIYDVQSDDTTAFALVTDVAGDDDPYSPVVAIEASLDPAFLAVVVLQDLRKYRIPSLTVTPTETQPIPLLPVYASTLLGYPPLTESLQRKHDFHQAFLAYRSDSGSSLASSSLIGAIRTDERVAFLGYNVSDTLRYQLELVHNSAATPEQAIDEALGACIQPQSRSFPPYLLARTVLALLATSSDPDVYRTSLQAAIQQRWQSSLQTSNNGTDPEPRLAEGRHRQGCLLFILTCRLSEQSAHPPSALDALRKHHKGRVLGDWLQRQVRDLTAQLSSSAQPSEEDHKLLARLTVAARMLPAASVEAQEEQQIVVTEEICAACQTQLTMRWDEHQNDFGWAKCQNGHVWRKYRLDFILRGPNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTA1</accession>
    <name>W3VTA1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA repair protein RAD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_02378</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_5_1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="616"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="1064"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1152"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="974"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS64041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1319" mass="144212" checksum="1C47585767E5A915" modified="2014-03-19" version="1">MTSQSSLEVQSQPSRDFFASSPSATPSSPRKPAQRQLEPPASTRQPQSEEAAAELDATEDDFSIVGSTSAQNDQPSRRQQPHRAAADNAKPLFLADEDEDLDALGGEDDEQAAAASSDFFSTQIDTQAKSAQRQKAKSDDEEFVPSAPSHPNGDRSSSPSEPQRKRATETACAATKNGNAKRLRSSSSSPAPEASRKRSPSPDPRLRHDAFDRRFLGTFVLSAWSLSKGSSYVKPGDPVRIFRPRKKPLPAETTSKASKLTNGGVKKTKQATLNFGGAASSPTSFFASKQKSKDKQDFIVRFSNMRGFEVGRLPLEVATWMSKLIDAGIADFEGVVVDCPASLTVGCDILLQVKAYIRFDAFFLSLTALANGGFDEQNDGLRPETAESEIEKSLRERKISLVRMFRVCDLKPSLSNSILKAHKAVDDFSSDAMLDQYGGDVAASAQAGAAEPASSPSAPIEVDSSSDEAAAAEGGIATQLQEAQQQTDGDADVDENDGTELNLNQLDEVYRKAQANDAHLPEVEPPDTFLLTLRPYQKQALGWMKNMEKAPGPSSQQDEASQANAGERNLSLHPLWEEYEFPLDYDQPEANERLVLSPTRMFYFNPYTGDLSLDFQRASKGSRGGILADEMGLGKTIMVTSLLHANRSAEEGEESSDEEVGDGEDGWAASGKRRSAAKQTSLASAFAASASSGDARRALLRASVAKGKASLVVAPMSLIGQWRDEIMRSSAPGSLTPMLYYADSKADLLAQLESGKVNVVITSYGTLVTEYRRFLDGGGAANRHLSSTAPLYCIDWLRVILDEAHNIKNRSTMNARACCDLVSRRRWALTGTPIINRLTDLFSLLKFLRVEPWGDFSFFNSFVCKPFQAKSTKALDVVQVILESVLLRREKRMKDKDGRPIVELPPKTIEVRELEFSPIERRIYDNVYRRAFMQYATLKANGTVTRNFSVIFSVLMRLRQAVCHPALVLQARKRKTKGGDTDAAGSDEVGGAEAGVDEEDAAGFGDGGDGDATPGTEDLRELVAQFQSAGEGEGEGESGGYSRAMVDRLLTNAGGDAAAMESECAICFEDPQIAPCYLPRCMHSACKACLLGYLQQCIDRGEEPACPTCRTGPVAASDLIEAIRTRPPASPDDRSGMIYVRNNLLTSTKVSALISHLNQLRAEGSFKGVIFSQFTSFLDVIQPVLARYHFRFLRLDGTTPQKQREKLLVEFQSPARESEVVLFLISLKAGGVGLNLTAATKIWLLDFWWNSSIEHQAIDRIHRLGQTKPVNVYRYLVKDSIENRILQIQKRKDSLIHHALNKDPKQTDTVGDLDILFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTJ6</accession>
    <name>W3VTJ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_00760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTJ6"/>
    <dbReference type="HOGENOM" id="CLU_068820_1_0_1"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834873" description="Translocon-associated protein subunit alpha" evidence="11">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27654" checksum="31C58D865704BC47" modified="2014-03-19" version="1">MRFFTLAASALVALVPAALVAAQAHDTPELGIVTTFPNNPHSIVKNGQANTVVFSITNPPKEDRLLTLQSVTGAFLNPKKTDGQRGRVLRNMTTTTFKSRPLRTVGGRPVQIPFDFVPEFKPQELSVEFSLLVNDEQTGKKHRIPAYRGAVQVVEPPKNWFDLQLLSVYVIAAATIAGIAYVVYATYIKAEDTTATGPKKFEKPAPVQQSGVQDEWIPEHHLRARKGKGKSTGALSSGDDEPSTPKRRGKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTN4</accession>
    <name>W3VTN4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_00441</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTN4"/>
    <dbReference type="HOGENOM" id="CLU_012862_0_0_1"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="121"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="333"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS64993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="567" mass="61646" checksum="FEC97077636AED33" modified="2014-03-19" version="1">MPVFKRRASCASDFSPSPPPPRSKKTKPASAIADFSAILTGDTEDDVALLPARAHAISYHKPLLLSRPQNVASLLEWFERVSDSRAMPWRAPFLDPAHHDPDKLKEAQKKRAYQVWISEIMLQQTRVETVKSYWLAWMAKWPSIDMLAAAPEEEVMAAWRGLGYYSRATRIHTAAKQVVADPELQGSLPQTPPELEKVPGIGAYTAGAISSIVFGQAVPILDGNVARVLSRQLGLYANPKAKATTDVLWEAARVVVEKAQEVKQGGATPGQWNQALMELGSTLCTPLKPACNECPIRASCRAHAEATLPASKGGVEDMEDLCKLCEPFPNDIKPEPAAKSEPKSKSGKKMRQATLSFGTSSSTEAKETARGSGDEALHAHVCKFPMKLSKKTIRTESCLVCIIRRPAGEYLLEQRPASGLLASMWQFPSLTLSTTEAGSTPAPPTPPTRAEIDDFAASLLGSKAAAQAHQRIGTIEHVFSHLHLTMHVYCLGLAKDVDLPAAKRKKEEGKARNFGSSLGDTATRRWADAAAVEAETMGTGMRNCWIAYQQQATTPAQAKTKPDKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTW6</accession>
    <name>W3VTW6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTW6"/>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="148" mass="16696" checksum="C33A58964F3E2172" modified="2014-03-19" version="1">MSLPKRIIKETERLIADPAPGISATPHEDNLRYFDVVISGPTQSPFEGGVFRLELFLPEEYPMSAPKVRFLTKIYHPNIDKLGRICLDILKDKWSPALQIRTVLLSVQALLSAPNPDDPLANDVAEHYKKDEKGAIEVSRQWTALYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU14</accession>
    <name>W3VU14_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PaG_01508</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU14"/>
    <dbReference type="HOGENOM" id="CLU_034756_0_1_1"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ETS64261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="391" mass="45053" checksum="D4CC074BA5FB77CD" modified="2014-03-19" version="1">MAAASSSKMQLFSADDVSKHNTATDCWVIHRGKVYDVSEFVEDHPGGDDLILRYAGKDMGETMDDPQEHSHSDSAYELLDEHIIGRLPTTDAEKQALTERAAKGGYSGKDDSIVITDDFHPEETDFSSDYKAHKFLDLNKPLMPQMLRANFSKQFYLEQVHSPRHLKHPARFFNQDYLEVFTRTPWYVVPMVWLPIASAIFFRSTTQFAANLAKTPLNAHTWYEAATKPTQFDTSVWSIALTQTAVCWVVGVVIWTLLEYGIHRFLFHIDDILPDKPMFLTLHFLLHGVHHYLPMDRLRLVMPPLLFFLLSYPFTQLAHVLFPTAVANGIIAGAFSMYVVYDCMHYALHHTRLPQYLKNMKQYHLEHHYKNFELGFGVTSKVWDYVFGTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU18</accession>
    <name>W3VU18_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU18"/>
    <dbReference type="HOGENOM" id="CLU_046722_0_1_1"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="4">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="383" mass="40717" checksum="3971219A0C41247D" modified="2014-03-19" version="1">MSNEKNAQELLKWGLANSTTAAGPSVEQISADIESGRRPDLADPHLYEAIMGKSEAQMMVEQLSVAVDESRSVEDRCTALDNLEMLIETIDNANNMTSMNMWPSIIGLMASSEPEVQTAAAWILGTAVQNNDKAQVAVLPHEAVRAVVDLFQSAHDKVRAKAMYALSGLIKHNPAAMDQFDKLDGWKVLRSALVDPTIGIRRKAAFLLNTLLLQDPNSFTTPVPSAAPSTATAVAPTASAGTVPLELGPETMRTSVPHPNVARALVESGILSTLLSSLLPPGTHGIDDADLPPPSGSDGDQDPRSDLDFAEKAAAATLAFATKLPDIPSKAHLDQKTKSLFKALLNELHGPPFDTSTAAKSRADELALDSQQLHTLTATINAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUD0</accession>
    <name>W3VUD0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUD0"/>
    <dbReference type="HOGENOM" id="CLU_328212_0_0_1"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
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        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
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        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="515"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
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        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
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        <location>
            <begin position="626"/>
            <end position="637"/>
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    </feature>
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        <location>
            <begin position="638"/>
            <end position="648"/>
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    </feature>
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        <location>
            <begin position="729"/>
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        <location>
            <begin position="749"/>
            <end position="761"/>
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        <location>
            <begin position="766"/>
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    </feature>
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        <location>
            <begin position="820"/>
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    </feature>
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        <location>
            <begin position="847"/>
            <end position="856"/>
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    </feature>
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        <location>
            <begin position="890"/>
            <end position="908"/>
        </location>
    </feature>
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        <location>
            <begin position="913"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="926" mass="96069" checksum="CF2E3AA799BE814C" modified="2014-03-19" version="1">MAQPTVELFSTSILSNVKVRTRHERFTSVLAIKKIAYVYHDLASDDDAKSRWRRKAKDPQLPGILVNNEWVGSYDDFEEAVEFGELELFLGVAATQPALTAEPHPAQSAVSSKDPSLYPTLPYAAEGAGRWKEPDADQFIDSLNIDEQDIDDADVDAMLADIGKLSVQPSSTAEKKYQPSQEAAVKPLRLAKMGPKTWHQRMPSGSPSPASSNGTRASPMARYSATQRSTRALAAEAAALTSNRKTSGALLRDAVSQGKTLDDAMEESRMKHIVSQDNIDDLFASLGLSNVDIGDDEVDQFLDQGAIPQGLRLGGDRVHKPSSAADKARDEAVARDLAQRAKQKGHGSARSSLLKASSDSSPPTRAAVKATEATSSAPATESSSQLPASTEDEVESAAAASKVDLLQEAPVSAPKEEVEGSSPSKPEHESAPRTAAAASLSEAPLVSDEQEHTPASASVDEAEPSTQAPESETDDAAQAAAPIAPTDAAEALESAAPVEPVELVEAVETEEASEPAKAVEAAVSVEAAEARHSSEAVEASAAAAESSSDAIEHTRSEDVGSSDTNDAQKASAPPASQDTEASVQAILTRASLEEPSEEQSKAAPAPPSAHSQDADVAPSHDQLEPSASSASIPSDSHAASEDVAKAKVPDAATEAAVPVKMPEIPTRADSQPGASKVDTGAPAGADDELQLELANAAMIASRYEEHRSEALDPVAASADAEQEPVEELTSVSAPQQTTSSEDAAAKVPATTSYTLAQSPGSADTHASISDVASSSRSSAATKHGSRQASSSSSVGASSSSRRAFDVSRPIVPTNGPQPLPRSSSSELSTSPDAKKKRTGLRGFSLGRADKESDSASRGRSASGPAKTVASSRHERTISQILREADAVLQMDDDEDGSNAGAGEDDVDDPAIFGSSSGDSSARRGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUE1</accession>
    <name>W3VUE1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUE1"/>
    <dbReference type="HOGENOM" id="CLU_2484265_0_0_1"/>
    <dbReference type="OrthoDB" id="2556109at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833415" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="8552" checksum="02BF7E6FEEB5697B" modified="2014-03-19" version="1">MKFATFSSLVVLLVAALSTTSTALPLIGGSQLGSATGSAGTAQSVQNNDYSHVSPGNQVQNGGSQKADLQGVAGNVLQGSGPLGLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUF2</accession>
    <name>W3VUF2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00903</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_009422_8_1_1"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="26"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="255"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="679"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="865"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="639"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS64447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="923" mass="104687" checksum="A2CB40C0362FE640" modified="2014-03-19" version="1">MGKKQQKKTAKGRLDKFYWLAKEQGYRSRAAFKLVQLNKKYNFLEKARCCIDLCAAPGGWLQVASKYMPANSLIVGVDLVPIKPIPRTITFAEDINSYKCRDQLRQILKDWKADIVIHDGAPNVGTAWVQDAYAQSELTLQSLRLAVEFLNAGGTFVTKVFRSKDYNNLLWVFNQLFKKVEATKPSSSRNVSAEIFVVCQGYKNPARIDPKFLDPRHVFKELDPATLAQEDQEAGVPLSLKGTSAGNAHANVFAPKKIRKNREGYADGDYTLFHSLDAMDFIKGQDVIGMLGSYNEISFKSDESKTLLDLPDTTQEMRDNCSDLKVLGKKDFRNLMNWRKEVRLALGLDMPKSKQKDLAEQIETVEVEEMDEDDQIDDELARLNEEAARKARKERRRKNELRQKKILKMQLQMTTPMDIGMDVMDDQLGSGNGDIFEIGSGEKVSKKALMQQADLSDDESDTIVSSHDTDDDDPQARAARLDAEMDALYDEFKQKQSDRDAKFRAKQARLKDAKNDSWHGIKDDEEEEDDDDAELSEDSEGGYDLVQRRKEQEETFDTDDEEDEEDERLERQAVEQSRKRKRDTDAAALAQADAPAKPSKRSLVNSLTSDADVTAQQSREASIWFDNPLFKDLGLDAVPADEEPLEDDEDAWEETDAEEEDEELSDDEDASDSGSGLEDEDEEDFEVVPQDHEEHAIPDEEWDLDGEDEEAGKQKRIKDHGLATAEAVALAQALVNRKITKEDLVDQGFSKHNFVDKDGLPTWFLDDEQKHYKANIPITKEAMQALRDRERALDARPIKKIAEAKARKKMRTLRRLEKAQKKAETINENEDISEKEKSSTINKLLAKSVKGGQKKKEVQLVVARGVNRGLKGRPKGTKGRYKMVDPRMKKELRAFKRKAKRDGKKLGSSNSKPRVAKGYGPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUP7</accession>
    <name>W3VUP7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUP7"/>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS65249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="509" mass="56389" checksum="879BC8394BB21758" modified="2014-03-19" version="1">MSSNATLSTPNNGAQIKASRTRGASHIDFKSATTGVAAKAMRNELNALVSGIDDPAVRKAFDAEMSNFFNLFNRYLAEKAKGEKLVWDKIQPPSPEQITPYAELRKATDPSILNKLAVLKLNGGLGTTMGCTGPKSVIEVREGMTFLDLSVRQIEHLNSSHNVNVPFILMNSFNTDDDTARVIQKYANHNVEILTFNQSRYPRVNKESLLPCPRSATDNKNLWYPPGHGDLFDAMNNSGLLDRLIAAGKEYLFVSNVDNLGADVDLNIYQHMIDTQAEFISEVTDKTKADVKGGTLIDYEGTIRLLEIAQVPSEHVEDFKSIKKFKIFNTNNLWLNLRAVKRVLENEELDLEIIVNNKALDSGEAVIQLETAVGAAIKHFRGAKGVNVPRSRFLPVKSCSDLLLITSDLYSLEHGKLLMNPGRMFSQTPVVKLGDTFKKVAQFQKRFKSIPEMIELDHLTVQGDVVFGRNITLRGTVIIVANEGNKIEIPEGSVLENKLISGNLAIIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUQ5</accession>
    <name>W3VUQ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUQ5"/>
    <dbReference type="HOGENOM" id="CLU_943963_0_0_1"/>
    <dbReference type="OrthoDB" id="10317553at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33464" checksum="DC11BFCFDC7EB399" modified="2014-03-19" version="1">MSIPAALHGRLRLLTVACLVPASAAFLYWAACHFYDTRLDTLDLGQETSKVTVARSSAPRWHVSLLLWIAQAYALSEYARLVLLLLRDPHRAQLCYRQRISATEQRSMLEDSEVRREMLHAMDTDDELESSILFDSSLESAVAVSTPELKTAVQRDDISTNMLLTPSCQSCDDSEMEAAKPAGCGHENQPGGEGSPVPFSLCACEEDDLLVAVEDDIRKPDAAGACPSSARLAHHSTHVEETVAHTDGDREDANHGDERSDASMHEPFSARDGANYVHEHLEEEQRYREQLLSAADESSMDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUT0</accession>
    <name>W3VUT0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase SUV3, mitochondrial</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUT0"/>
    <dbReference type="HOGENOM" id="CLU_010647_0_1_1"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001549">
        <property type="entry name" value="SUV3p ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="450"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS65378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="853" mass="91380" checksum="A5F8052E683E4B6A" modified="2014-03-19" version="1">MLSRSIASVAAAAAATAAGTSSLAGWSASTSRAAASSPALARQACAICCGPPPAHIAAPSRGFQSSALVARGVPPRGGSKSGGASRFGGSRGNDKRDRFGKPRFGDNRGKKRIEADFSIPEPPTAQHVARQLVDKIDSLAGNPHFPAQLVVYGIKGDAARQVLQLYTPSKSPQADQELAIKLFRTWSEEAQDEIMDIALLHDGGEVHRPGVFGYLPDAISSFTVEGEACLGRFCLSAFLDWMDSGYARVETSGNAGEVSLARSQLMLLRSCMDLRFPAHQYPHARTLMRSIHLHVGPTNSGKTHGALVALSKARTGVFAGPLRLLAHEVWDRFNTGTVSPGVAPRACNLVTGEEQRTVDALAGLVSCTVEMVSNSRTVDVGVIDEIQMIGDAQRGFAWTAAVLGLPAKELHLCGEASVIPLIEKLAEACGDHLTIHRYERLTPLSVADESLHNDLARIERGDCIVAFSRSGIFALKREIEQKTGLRCAVAYGALPPETKAEQAKLFNEGKLDVMVASDAIGMGLNLRIKRVVFDTLTKWNGSEEVTLSASQIKQIAGRAGRYGTQSASTKPADLGGIVTTRHEHELEVLRAALASPLRPITRAAIQPPREALSQLSAMLPSAKPGGGLRALSQLYADVALLARIEAAHYFVADFSQQLAISPLVESASAGMLTVAERETFSNAPANMRDERVVAFLTSAVAQFSRGGLVRFDAAADALGMLEVEEQLVELMHQASEARRRATESANSTTPPQDPLPLVAYLGHNSSGGVGGGGSGAHPLINIATLLVMESLHRCFTLYLWLSFRFPLAFCYRAEVERRKKRAEDAIDFVLQGIRFGRAKRLQALGRAPRPHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUU4</accession>
    <name>W3VUU4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005909_0_0_1"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="932"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1335" mass="143292" checksum="95E7B0611DD999F7" modified="2014-03-19" version="1">MATLQMHRPKPRHRSPSLNQAAPSSPTIIRTPDFILLPSVPTHEPEDNLPSPMALQHQFAMAQAQAQAQAQAQRSSSSCSSSKNSLGLGLCSSSDEHHKDADELEEIAEPEPQPESHLDHATTSHDALRDLRNHQLESLQAIVHSIADAHLQEATHAAASSNTPHADLTRILDDMFASLRRIGGHNAPLSPTFARPSAHHMSDLDRLVLLVDTFSQITATANNAEHASQLARLNALTNALVESNRRIASNQLDSPPRTPRSLAWSESMHPRRSSIHQHHMHSPQSSSHLSGSRGSWSSTHSAATLSTSSDEAAPAPHKHLAPLEHAAAAWSPRRTELLSQAGLVQPQQQHVDGSVFDMATIRTRTNPFSIETLYTREPFASTTTVAPAPRSPRSDQASRAASTIGDTSDSIATALPNRKRFSVQTDSAASTSLPGYSYDAPTYHADEKQKASTLDARSASSEELPGYDASPAPAAFAADAKKPIETPTLLERRRAKLAAQHSAYAARTPEDLAMVQSSIDRLSTVMPQLNNQRALSPEHQRQAQLDTIIGRLAHSNAHRLNDQRSEPPSFRPSRPAPSPHPTLAPTPVEQAPEPELPATPTTPVSLHTAPSASSSRRSSLLPGAFGRKLSMASIGNALRRASIYDASKLRSREGSESSTDGTTAAAAAPATRRRAATTADSRTKSDIAEGLTSLFNDDGKARKASASDASAARLQAQSSFRAIDFADDTPRGRDASLQPRASVEEEDDSMLDDYSFATFDTQKSNHRLSVVAPLDSPHSPVSWAASSSAGSRRSSQLVSSPATPTWPRSPLTPVSPAASKRLSKPAVTFAADTLAAPPLGKSTAASFQSQLRDSGFTPLRPGKSLASVPPPSLHEYRPPAAASASTTIAVSNPWQDIVCYAVSGIEYGAGDAKLCDSSSWPHKSNTADPRARPSASAAPASTSAATPQSDCRVDVEFLAEAQPALGTVSVMLWTSTRVDAPVELAYELVAERGDVHSRRLRIWPVARNVLLNVFASESRAGGVEVVLPAAVRLGQSGRVAVGAQLSRVKLVLTEAEARKGAEASRAEGMVEFPLSARELSCRQEGGLGCAMCMRAGRSTPVMRWEGGMDWRALPSEGWEELVDAWMCHGDQELNRSLTETAVKFSSSLHTQASTSARTVWVGDTYIVASLDALEQVVVEQNQVACSLCRTALGTVEGSSARLSKYLIELTGDASSWMGVLLATLQYAAASHGARRFHLCSPLPSTTGVEAWLFSRAQYTTSLSRHWTSSQNAECVWKGYRVLYRTPTNQDSEHVQLPASIAHWTIEAMQRCNDVLPAELRNALPGWSTAFLARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUV0</accession>
    <name>W3VUV0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUV0"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000039">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS64602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="183" mass="20057" checksum="2198350AAC8CB85E" modified="2014-03-19" version="1">MASASTSVAGAGTNGRPVVFMDISIGEHPAGRIKFELYSDIVPRTCENFRQLCTGEFRPNHTPEGYKNVIFHRIIKDFMCQGGDYINADGTGSRSIYGDTFEDENFSLKHDQPGLLSMANSGPGTNGCQFFITAQPCPFLDGKHVVFGKIVDGLLTLRKMENVPTGANNRPKMDVRITQCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVV0</accession>
    <name>W3VVV0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVV0"/>
    <dbReference type="HOGENOM" id="CLU_118703_0_0_1"/>
    <dbReference type="OrthoDB" id="2541982at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="137" mass="15444" checksum="E60D07CE4127BD7E" modified="2014-03-19" version="1">MCFTDELNDVHASADVGMRECVEYQIQSYVQEERIEPAHSAAGTSVRTSSIESSTLPPPYDESASEKPRGKVGFFRRLLHRSPKKTAVQQELPSYREAELARAWAKVGIDINDTKHGPRPACTPEEWIRAMQDSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVW4</accession>
    <name>W3VVW4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_00355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVW4"/>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="654"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="724"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="272"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS64921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="806" mass="87259" checksum="F95022ECDC3BB01B" modified="2014-03-19" version="1">MKPSMRRHTFASVEKALAESMAAIGEKKKAKKDFGVFAISVLPCSLSRVVRKKGSDARRPRETHTATSANRFMLDSATKSEATALSGNHRGEAAEADEEKDGSSDLAALRRWQGRCGLQQRSVDFFGSHTFVAGRGERGDWAVCSASSRPAAMTGKNEEVAEGSADPASHLAQPDTRLDQSEHDIGEADRRRCDTGESSDAAGQGAGAGADLEAWSSAFALSTTDLLQGRRRGLLFLALRRPLSPAFPRLQLLPLRASELATMGRITNPYVLTALACTGGLLFGFDISSMSAIISSPNYLTYFGPKDLTVECPDRPGALCNIGPSPSVQGGITASMAGGSFIASLFSGIVADRFGRRSAIFLGCILWVIGSILTCAVKNIGMLIVGRIFNGMCVGLASAQVPVYLSELSPARIRGRLVGCQQWAITWGICIFFFICYGCSFIGKQIDGQQDGRGTASFRVPWGLQMIPALVLMALVPMMPESPRWLITMGRNAEALEILGQVHASGDQNAPEVQAEYKEICQNIEESTGEGSGYIDLFRNGNAWRTHIAMFTQIWSQLTGMNVMMYYLSYVFEMAGITGNIALISNGIQYVINVVMTVPALLYIDRWGRRPTLLIGSTLMTIWLFAVAGLMGNYGHPFPNSGNSVVQWQVTGPASKAVIACSYLFVASFAPTWGPVSWIYVPELFGNRLRGKSNSVSTASNWAFNFALGYFVPPAFHNIKWRAYIVFGCFTVAMTIHVFFAFPETAGKTLEEVDEIFQSGVPAWKTRKGSGALARDIEAVKVGNAPVFTRQASTPSDSADEKEFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW19</accession>
    <name>W3VW19_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW19"/>
    <dbReference type="HOGENOM" id="CLU_980477_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="284" mass="30779" checksum="39EF71F754D511BC" modified="2014-03-19" version="1">MEADPHSGVCSADQLNQLNQLNQLTHRRRASPSRVIWSIRRARIVCSAAPNRIRTLQSDAGETDGHDLAVGRCHSPAQRYTTAGRHHHVATVTRTRWDGYSRTTAAARSQQPAASGGRVEHEAWAGDASASAMPLLPAILGSWSSLPLAAACCARLACAADRRQILQRRVEKAATGFAKLTGVGLASPRLACPARCTLRKVRINKLCSSQRLSNSESGGQTEPGMARSIPFHRIHRILTPFRSKSILGSWHLAAGILRLTSCGSCAMIAQHMAPNQTNGIWRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW20</accession>
    <name>W3VW20_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW20"/>
    <dbReference type="HOGENOM" id="CLU_089470_0_1_1"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000046">
        <property type="entry name" value="Peptidyl-tRNA hydrolase ICT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="96"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="247" mass="27494" checksum="F463C4A385C2DAFD" modified="2014-03-19" version="1">MDDGRKRGSGAQGKKRGKMGAVGRLVLAGMVASQARSMCMARRTLGIARPMAQAKTMPASYTAARTFWSTVPRRNADGSDEEMEARRRWVSAFEPIQLRRNDMDVTFSRSSGPGGQNVNKLNTKANVRLDLSQAGAHAHDSLDAAHPRKWLTRDIVSRIAKASPYYVASDHSMLVTSMRHRTQEANVQDALEKMHAHILALAQDGLEGETSQEQRDRVKRLQQAEARRKKTNKIKRADVKSGRKFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VW31</accession>
    <name>W3VW31_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VW31"/>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="290" mass="31818" checksum="B4335B5FAF28B2BB" modified="2014-03-19" version="1">MVLAAVAQIKSTGVIADNLAQAVSVIQRAARSGAKAIFLPEATDFIAPTAAVAELTRSADNVEFVKGIQSAARDAKVWVSVGIHEPPSAEQDATDMVENRGRLRCYNTQLLIDQQGDILDKYRKLHLFDVDIKGGLKILESDSTLKGSQLLAPRQTAIGKIGLLTCYDLRFPEPSLSLRRQGAQVLTYPSAFTVRTGAAHWETLLRARAIETQSYVLAAAQVGAHDGTKRVSWGHAMIVDPWGSVIAQAPDIQPYKATYCMADIDLEALENTRQEMPLWHQRRDDIFPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWA8</accession>
    <name>W3VWA8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Jmjd1a protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWA8"/>
    <dbReference type="HOGENOM" id="CLU_012595_1_0_1"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="7">
        <location>
            <begin position="571"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="818" mass="91692" checksum="9BE2164A9902C115" modified="2014-03-19" version="1">MAESKIKTIKTYRNRKSISSSRESTSSAPASPPSPASSLSSVEDEVILIPPSAHPPPTRQPPPPPSATPVRTAYKRNAAQAAQQNIQQLHQSYADFDGFDTSDTASSSKKKRLSNGVRTKVEQDSISRPSTPSSAPPTTTHPRKAARKQASQSTSSAARTPAPLRGRRFQDDQGVVWELQVGSCQAAHNRNWRKCVHCITKRAGDTCRFVDFRAFQVDPHTDKITPPDQDHTSHPAFLFSPDSDEVMDLPIGRAISPAHLSQVQGDVARALLPVLEAELEHARLPNLLRRPRETTCRQMCEFCATSIFSASWFCRRCGREYCADCKHSIDHSDSIDHSDSLDRQLAKRILRCDQTLPHATADLVPLTRFDEALLEQEVSAMRQMLTDAKTDGVRASAPAHDAPAAAASTSNEASEQFMPKTEDEQRTPVNWKDVPTNQAGITADRIVGHLDLRTFDRASFDTDDFRCEWAHGEPLLVRDVTGPMHHPWGPDALQSRYGRDHCLIVRSDVEIAEPKQVSVGDFFATFGQDDTSKQAALGRGHWKLKDWPPSAEFKAEFPELYDDFNRVVPAPDYTTREGVLNLGSCYPTGVIQPDLGPKMYNAWPGSEAPGGNGTTRLHMDIADAVNIMLHASPPTGDDVPEEHRPGVAAWDIFRAQDADKLRAFLRKEYSHIDFRDDPIHIQRFFIDAKQRVKLYQEYGVRSWRIYQKAGEAVFIPAGCAHQVCNLADCIKVAVDFVSPQNVDRCFKLTAEFRELVQDYKKAWKEDVLSLRTTLWYAWCTYRQMDGQGPNVWAKQRREVKKEGDSQMHRITRRVLQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWN3</accession>
    <name>W3VWN3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00246</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWN3"/>
    <dbReference type="HOGENOM" id="CLU_025152_2_1_1"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="238"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="447"/>
            <end position="450"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS65181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="536" mass="57997" checksum="45094795DBE6C5BE" modified="2014-03-19" version="1">MPSPALPAWPPALPRASCDYLSAQATDYALAHGLVYRPVASSASELPPSDSAIHAPFSLLPSPFPRPLFEKAQAIQPTYDRLYAHVSADHRFLARVIGESVVHVDEFQKQLWDIYVAVKDELVQPLSLGLFRSDYLLHDQQSAGAAEESMGSRHGELGLKQVEFNTISASFGALCTKVSGLHRHLAQTTDYLGAHSGLADLDNLPENKAQDVLAGGLAAAHAAYVAQKQAASEAKNVYVLFVVQEGERNAFDQRPLEHALQRQGIRVVRQSFAEIADRITATEGDSSRTLYLAHPVLGRIEISVVYFRAGYGPGDYPGAAEWETRKRLELSRAIKCPSIAVQLAGAKKVQQVLAEPGELEALLPSLGSEMASADQLRETFTDLYPLDDSDLGRTGYELALNAPEHYVLKPQREGGGNNVYRRDIPGFLAQLDHGAGSVARRQAYILMSLIKPPAGLGNYLVKAATPTNPATGAVLAKDTVSELGVYGAILFETRADHKVQVHHHQAGGYLLRTKGRDSDEGGVAVGFSVIDSPFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD00</accession>
    <name>W3VD00_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD00"/>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="7">
        <location>
            <begin position="47"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="513" mass="55647" checksum="959655C3BFA701D2" modified="2014-03-19" version="1">MTPPTATNEASLAQLSLGTSVGEDKKRMILYAFMMGCSGHQSPGLWTHAADRSRYHNKLSYWVDHAKLLESGHFDGLFLADVLGGYDVYAGNLDAALASGAQFPVIDPLLLISAMAAATTNLSFGITATTSYVHPYELARRFSTLDHLTNGRVGWNVVTGYLDSAARQFGAKNQELHAKRYEVADEYMDVVYKLWESSWADDAVVHDAASAVYTRPERVRQINHRGKYFESVPGPHICEPSPQRSPVIYQAGSSGPGMAFAAKHAEVIFIAAHKPEVAKKRVEAARSGAAAAGRDPASLKVLALLCPIVGATDEEAQRKYDQHLAHGSDQGALALFGGWTGIDLSTYSDDEELRATESNAIKSAVENFATQDPSVPKWNKAAVANKIKLGGLGPTIVGGPESIADQLQQWVEDAGVDGFNLAYTLAPGTFEDFVSLVVPVLKQRGLVWNDYPQAPQPQPDQVSDGPQHGFGLNEHLGLTSREKLYGIGQKHFRNDHYASRFSWKAGRDAPALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD48</accession>
    <name>W3VD48_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zeaxanthin epoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD48"/>
    <dbReference type="HOGENOM" id="CLU_009665_19_0_1"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="435" mass="47224" checksum="8F11F100ECD050E4" modified="2014-03-19" version="1">MTQTTKPFEIVIAGAGIAGLATAVALAAPGRRITLLEQSRLNREVGANISLQPNAVKIAKRFLKLDTYLFGDNSLGRGVPDKAFLLYGTDDKLHMKIQLTTEQYGEDRVCFHRVDLHSALRQAALDSGAHIHTSSRVTKVDTEAGKVWLEDASEMCADLIIGADGIRSAVRSAVVQADAPALPTGLSAFRTLIPMDDLRDIRGLPEGVQLGQDQTLMIVGRDRRLVMGPSRSGTVLGVVGLVPDTDRTKESSSWNCQVSVQEFAEHFDDFPAWTRELIARSVEPSIWQLRDIAPLSAWHRGRAVLIGDAAHAMLPTQGQGASQSFEDAEALQYLLRDIGSNSSKEELERALAAVYAARIERASLIQAYSRQQAKPGTSDAGKVTLNPREFMDYNCNYEGCQSWLARQAAHHSNKDHTPAASSLFDAVAPAAVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDK2</accession>
    <name>W3VDK2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDK2"/>
    <dbReference type="HOGENOM" id="CLU_072378_0_1_1"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="284" mass="31194" checksum="58D736F267735E78" modified="2014-03-19" version="1">MTTEASTSAAASAPAQSSSSSSYEPSSTFIESSSAYRHASSDGSGDEEDDDDDDEKLFAELDRELDSMEDESNFHPRGGDDTDTVAGFDMAEFRERRMEELRQEIAAAKSASGGEHAVMQHASTASMKGLLTEITHEKDLIGFSSTERQVAIHFFHPKFQRCALLDRHLTVLARLHPGTLFLKANVLNCPFLTQKLNVSVLPCLITFKDGVSKDKIIGFEELGNSDKFSTGALEWRLGQSGIIDPRENRKPIFGFGNDNAVSDTVGRGVVGARKEEDDDFWDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDN4</accession>
    <name>W3VDN4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_06566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDN4"/>
    <dbReference type="HOGENOM" id="CLU_032957_9_0_1"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834362" description="Fungal lipase-type domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="7">
        <location>
            <begin position="116"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="319" mass="33542" checksum="552421CD455D215E" modified="2014-03-19" version="1">MKLLQIASALVVAALSATSVSASPLDSDVLAYPAGVQRSVEAREVERLVARDNTAPTSPLTNYQQYQFPAQLSQAAYCGQPVGAKVGDAQLLWTAGDGRSTPLTFVAYSPSRGVIVSHQGTNTSSFSSILNDADFALDPVNSRLSYLGSVKVHGGFQDTWLRTADSVLAQVKSALAAHPGAAVLTVGHSLGAAISLLDALYLKKQLPSSSVKSVVFGQPRTGDKAFANAVDVNLPGFVHINNGRDPVPRLPPAIDYQHASGEIWINPANSLSAVTCPGQENENCILSVNPFTYDVSDHTGTYFNVHIAGRGENCPAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDY5</accession>
    <name>W3VDY5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDY5"/>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="277" mass="29920" checksum="CD85094014E47EA8" modified="2014-03-19" version="1">MVTVAFLPAEPERCCLDIDSLIATLPASIRVARHVDAATDALVWLPNIAQGNTAPEVARLLEGSNVKWMQLPMTGVDDYMPIIRATRGRIQWSCAKPPPDTTRVDTLQGKQVVVVGNGTIAKALVKMLLPLGCVVSTYDSASAPEWEKADVVVLACPLTATTMHLGNHAMLARLRRGALLVNVARGEVVHTPALISAIRSGLKAAVDVLDQSELDTQQKEEVQRLVGEGKLLVTPHSAVPMRIVPQVLGERIRQNLARIEQGSWHDCIGAVDPDKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VE89</accession>
    <name>W3VE89_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_06181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_246884_0_0_1"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="142"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="896"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="975"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1401"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1015"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS59864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1491" mass="162770" checksum="33294AE04794F9B8" modified="2014-03-19" version="1">MPSTPHGANLPATTHNVNANGVHRPSPISSDTTAIPGPPSKSIMATDTNGHFQDSAQPATDKNKRSASSPHKLMIGVPPAATPNPPRSSTEHTHPHNDAHNPTQNGNVSSELKGKQKQLDPIHTVSLEQLQQELPLEETDLVSLAALVERLANYGYESLQNLAETLPSLPSSSKRAKIFSTALDVRKQFIKLLVLARWSKDVPDLQKARNIIALLSEQQWQHEDVFAGLTDIRKILPNARMRNADLPTAIDVLQTGTYRRLPASIKDMAVAPPPLTDQQALAIVARLQDALRTRMACRELVPAPLSDYSIHDAKVHFHVRGLFRAQLTASSGGRDQDADRPDQHAESGAADAASSAASADDRWWLLDLSFDATPTGSCAESSLKLFPKRPKKAYRERLRVWGDQELAPRSQATDAARDANADAAPTASEPPHVLSTADTQGESKPAMQQSEPQDASPQPTQPDADLEASFKLPKTRDAPLVRLFAFLQERALHYQMDILQHQAYELCRLNWGSNLRIETAERPRRLTVHYWTHAQGAEGTSSAPDSPAVGGSIQISLVDLPDQAAVTKTLAEIFDDDAPSGCDGASPTAVKRRGLRVIWNAHASVLSDSETSDLDIDPHNLDIEATLSLVIKRHTAALLRNLQRRLLVSDHPVSRLLRPEDCTLCVEHARRQGDEFSTATEATSFNFLRVELHGRNRQRAARTKRAAAVSTMPPLRLSADPVTGRLLLDSEAASVAAVAGLHGSTAPASEFTASILTTRPASARLSEASDRINGSIDALFDVLYRLEVFARVQDWERMASYLGLRTVRKLSLRPQDLAKFGSSVSTDAAPQLFIPLRKSFPGYFLALQPSELAGARIALVYVVQMPDPSGAPSLTVQSIEWLDRVKIANASKAGRGFPADAAMPGPGAGKKRKAASAETSETQEADAGIAVRELSMEELADVHSYCIALVSYFRVEQQLRMRGIPYLHVAGSKADSATPPKWRRRVAPATSNAHVDARDNGLFDDDDDDDEGMEAEAAAEPAGVDSQEQAVETGVAALVPTLCLRAADVLGPAKAHLTKPNVSLRVCDWDESDKTCVQVLVKLRMKSRRFRALHEVVAYASSSDQHAQSAATWIDFDDATCVLAISTRDVDNCIPIFHMQWERVMRMVMLTREVLNASRAWQQRALRARTSCKKPAERVELCRFQLDTVVFSYGTLGVEDGARKLLVRVRWQDPKMEMAAYGAMPVAQNGGYVVEFGSAPVSEVEVEAAKSKDEALSAWFDAQHAAANPHDVMAFELRRTLNVAARSAAMSAVAQPQLERLVWKGFLRLLRDTLPVVREVAPLATQCLDDPEVPELEIRGATWFRLRFHDRYALDIRLATRSRLVIADAARALFRHERHQKAAAPGGMFAGSHLLRDVLAGNPPSKDGAPEDRSAADAISAPNGTTQFDPIPKLDEVLHKVEAALRGDARVGDVWDLRRALLVSLTDAALVHKLMPQLVQLVAAEVAAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEM7</accession>
    <name>W3VEM7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEM7"/>
    <dbReference type="HOGENOM" id="CLU_036311_1_2_1"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS59980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="46737" checksum="CFA0AD1044C4E840" modified="2014-03-19" version="1">MASTQSSGLQRRRGAGAATAAAGPSTSASRIDDDDYTPSRTGSPAPAGSSTPTRSAAGIPASAYGSRSATGSVTTYDESTGHRVAYDPRDLNDEREIGENPRLTLMEEILLLGLKDRQGYLSFWNDNISYTLRGCILIELALRRRIAITKDPMRKRFGLTERMVDVIDAKMTGEVLLDEALKMMKASERMSVAQWVDLMSGETWNVMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPLNDTSCKDAVLRRVLTLLTSNSPSVHAGTFYKEDASSSGRPVALRVTRALCLLCCSFSANVLENALNHLSYEARESAFQKADDILEEFACWPMAPSSGLAGGGVGGGSGSGVPTSISSNGPKSKANGGARIGEGSMLNERADDEGVVGASIQELAKALQKELDQEGDTFMFECIAAVLNVLSRMDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEP4</accession>
    <name>W3VEP4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEP4"/>
    <dbReference type="HOGENOM" id="CLU_1288744_0_0_1"/>
    <dbReference type="OrthoDB" id="2549016at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004832992" evidence="1">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="210" mass="23661" checksum="D7CB3BDBFAB1DC2D" modified="2014-03-19" version="1">MFLFAWFLLFAVGALAGGSSSRPSPDVVRSYRDLHRGLLEPINLYNPQPQTVAPLGPPWRGRNKLANMQNYIRNVYNHEAYIDPEAGAALTRLRGNMQWIINHPNDPRIKDYQRGLVAVMEEASAQAKHDMQNGLHPVNVRAQHLDPIRSLSNKVNGVVDLFGQGRSELMSSHLEQADRDRFAKAFEVLFSEKHLLSSATRLATTVPRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFH6</accession>
    <name>W3VFH6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFH6"/>
    <dbReference type="HOGENOM" id="CLU_029469_3_0_1"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="212"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="477" mass="52038" checksum="B6B09D49826FA161" modified="2014-03-19" version="1">MATAEQKKFVSQIDANKAALIDRLAKAVSIPSVSGDAAYRKHCFEMADWLLAELKQLGATAELKPLGKQVLDGQEIELPPVILGDLGKDPKKKTILVYGHFDVQPALKSDGWDTEPFELITDEKTGRMYGRGSTDDKGPILGWLNAIEAHQQAGIEMPVNLKFCFEGMEESGSVGLDELIAAEKDSFFQGVDAVCISDNYWLGTQKPCLTHGLRGIAYFKLAISGPARDLHSGVFGGVVHEPMTDLFTIMSKLVTAKGEILIPGIKELVAPLTDEERKRYDVMDFQLSDIEGATGSKTTVSDDKAAVLMGRMRYPCLSLHGIEGAFSEPGTKTVIPAKVVGKFSLRLVPDMTPEKVNELVTKYVNDEFAKIGSKNTMNLTSEHGGKPWLADPNHWNYEAAIKATETIYGVKPDLTREGGSIPVTLTFADTLQKNVLLLPMGRSDDGAHSINEKLDISNYIEGTKLLGLYLHEVAAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFK6</accession>
    <name>W3VFK6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_06531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFK6"/>
    <dbReference type="HOGENOM" id="CLU_291044_0_0_1"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="9">
        <location>
            <begin position="829"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="784"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="646"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS59607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114799" checksum="9AFA8AD5EC942C11" modified="2014-03-19" version="1">MAGHTSVNGADTASMANAKASSSRSPLQAAAASSEAARLLPQVLQLVQDFIASGEKPETYVAPWGSIPDFRKAVTLDLPDSVDTDASGMPDETALMDAIRLVFDHSVNPWTGRFLDKLYAATTPVGIAADLVLSAVNANAHVMSASPVLSLAEERCVEGLCEVFGFTDKKPDGLTMPGGSAANTLAVQTALANVFPPFRTQGVLGVVQYLADKGKAPRPLLFTSSQCHYSLDKAAISAGLGLDSVVKVACDTTGRMCPKALEQALEQAVQQRTGTPFLINATSGTTVLGSFDPLPELAAVARKYGCWLHIDASWGGPIVFSHRAEYAGLMKGSQLADSITINPHKLLNVPLQCSFLLVRDADTLSANSLDAGYLFHSKDRRENAAMKTMGCGRRGDALKFWLYWVRYGKQGFGHHVDAGLQLATELVEYIRSKPELELGPLADPLFLQICFRPKQPDSADDAAHALEPEQVRVRSKGTQFVYQELKRRRMFAVDFAPLPNDIGDYIRLVVHPRTRMDDLRTLVDQVAEIGSRRLLPTNSSIHHPSFAVPNRLDPPRMYRSKRSTKQSSKLKILPEEPEDSSTGGPSGGATPLNASSPVIGAASTLSASLGGANTGGYRRNPSYSEPPAPSASLAAANANSPHHSVDDDDSSSDDAAEGEDEEAVEVYKQLAQIPEGSMRRDARRLTKRSRAKLPRVTAYSTATSYRMRELTKWLNARRSSHHTNVMTFDECLYTTYTYKHVDEARGLVPAPTSANGSGKHHSSRSKDASAKTADLLGIPELRQDAQQHDGSAGAGEREREGEGADETAAAAAAKRKRSRFAVDDVVPELFIMDYGTIVIWGMTLVEEKRFLRELRRFEVERLASEDVESEDLHWYLADYSRIYNDVITLRRGSSYMTKLSLSHALAQSTKISFFEGIIDNTIESTKDIPQSIAESGKIGMPPAEIMKQIGHLFILRMNIHLVGSIVDSPEIFWRQPDLEPLYSAARSYLEIPQRIDLLNTRVEVLQDMLQLLKDQVTSSHSEYLEIVVILLIMLEIVLGVATMLVDLYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG46</accession>
    <name>W3VG46_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_05494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG46"/>
    <dbReference type="HOGENOM" id="CLU_900539_0_0_1"/>
    <dbReference type="OrthoDB" id="2544183at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833023" evidence="3">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="309" mass="33508" checksum="B1F76E15009C6D43" modified="2014-03-19" version="1">MTALSALISLLWHVGQAALTVSPFIVIIGLTRTPRNAVYITPETLVLITVSYALRYGDDASRHLFALGQLGAGLYLVGMAVASAMAFRIRARVSMPKTQAIPVRTSADNVSTEDDAPPPANNRISQQLNKNSIVCILCYLGGILIHNSTVALFGWLGIRLFGTPKPLSAIWLEHWSVSVSALQIVALWPQYELMIQINKAKASLPHPDLPLPEGLSQDEQSRRFEAPKMLWAFLVAFQGGTAIMFPSLLMQGIEAKGRDDPLVVTTTIAAFHMIVLLGLVARLKILPPGRLITSEEAQAADQEAGIRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGC8</accession>
    <name>W3VGC8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGC8"/>
    <dbReference type="HOGENOM" id="CLU_290515_0_0_1"/>
    <dbReference type="OrthoDB" id="2121319at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="640"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1055" mass="111582" checksum="B1EDC73C48D07DF0" modified="2014-03-19" version="1">MTDNEPRQLLPETESHQRLSAKLGASRPPPPRSRSRVNPSSTSKQQSSKSAASDHDDAQNNPAEPGSAQSAEASDAPDHQASPELEASGSASPVRMTVQRAVSGTSIRSSRSVGAVSDIPKEEIEKALEGLNRDDLVLALGRAKVQMDEIEARLEEQVLENETLHGSTASLTQQLGQAEHEVQSLHSLVKQREDRIDEMMIEQERIEGEVYSTMQIIERLRKQLADSERGRNDAEKRYLDQTATMDKERQYYMDTEALLKSQKATQSAAYEKLLTGHNELLREHERLTNNLASIKANGAAVDATSPVTTHKDLAQGSAHTSQDSALQDDSVDSAHPGADTDAAGSQSHKTSSRGAHTNATTFADERDMATMIEELSTLQKSHSSLSETMVTLQAELKDVRAENVSLRDQNETFMDILQEKTFSGALLNESAMLRGMRSASFGRLRAQDGLLDPYDDDDDDDDDDSLDVDDSADDSAAGGSSVASRTIPEEDEDDVDDVPDTPKAPPEPKLKASRRKRADSSAAPLPTADLASELEGSSAQQHPSPGDRAARERRSPSQRFGVVSDDLGELQKEVRELREANQALTLYISKIIDRIIAREGYENILAVESRGTVRGPRHKASRAKLAQSGPSQGSGKPDAATKASSAAGADASGQASSLFSFGGASSRSASGASRASAPPKSKRASSIDWRSLPFLGGGGSGSGGAAAGETSSNLRPLTLQSDNLLIPPRDGSARKLRTSEEMEDEHDVAERERIRRELLSRGIQPPKHQLVQSPTSPLKQRPQSVSAASGSGGFAAFFSRVVGGASSNALASPGQSDTQSQASTTPGGSLDTGFERAVSSTPAGDAGRREAERTRALQLSEGGSSVTKLSSGPGIASKARQLRAERHQQTLDIAADSAGNPFPSSTNSSAAASRATSGSNSAADSSIWETSIAGDESYTLPPPPGEGARGRGEVESVDSPLVGYGGGLPPLPHETTGDEDPQAFRSPSLAQMPLSTASQDQGWKRAFRRISLLSPTAAPAQPGAGSSDEHAQAPDELGAASSESPAEGANGTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGD1</accession>
    <name>W3VGD1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_06300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGD1"/>
    <dbReference type="HOGENOM" id="CLU_002656_4_0_1"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="613"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="336"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="403"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="336"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="482"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="542"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS59776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1212" mass="131170" checksum="BE9E6EFA1CE9F9B4" modified="2014-03-19" version="1">MGKKKGAKKGGADDFWDEAGESIDNNNAALNADDDQDEAPTHKAKNLFAAMSLDDGADDNDDDDDDAPPPSKKDNKKAANGKAAKDSEPAPAPAPAAADDYDDSYGLMGAIKNANKKGKKDKKKKKKNDDFDFDEFAEDVSGNAVAPAEQADAEDDLASKAPVQGTIDDMLDDEFPEDKPKKKAAAQKQTQDEDAASAAADDADDGAPRILTKKEKEKLKKEKEKAKKKAQAAAKKAASSSQPAKQDAADDDDDAADADAADTSKGDDAPAAASSASKKKKKGKAAASEPAPAATPAPASGKKISPALAALQARIAAQKKAEEEAEQARLEAIRAEEERERLEQEEEERKEAAKRAKKEKEKAKKEQLKKEGKFLTPKQKAEKAAAEARMQAMIQAGHIKVEGLENREASGKPAPAKKRAVVDNRKKKGPQKREGGLTIPEPVAADEKKDDEEAKPAPAEAPAAEKAQTPAPVEEAAKADEPAEEDEDVKDSWDAESEDEDVKDSWDAESEDEKPSASKEQAKSDAAAAPAKTNGKAAADKAEEDDAEDAEDDSEDDDSDSDDDSGSDDDSDSDSDDGMTAAQRQAAEKKAQAAERRKERTEQAMAARSRDDLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPTDVLQSKTAVLDKDSPFEYKVPGLLVIDTPGHESFTNLRTRGSSLCNIAILVVDIMHGLEQQTIESIRLLRDKKTPFIVALNKIDRLYGWDPTPNGAFRDSLEKQQRATRNEFEERTNQVIVQFAEQGLNAVPYYDNKNMGRNVSLVPTSAFTGEGIPDMLRLIIELTQTRMSEKLMYLSELECTVLEVKVIEGLGTTIDVVLSNGVMHEGDRIVVCGLNGPIVTQVRALLTPQPLKEMRVKGAYVHHKMVKAALGVKIAAPDLEKAIAGSRLLVVGPDDDEEDLKDEVMSDLSSLMNSIDTSGRGVCVQASTLGSLEALLEFLRVSKIPVNGINIGPVFKKDVVRCSTMLEKAKELAVILAFDVPVDKEAEKLAEELGIKIFTAKIIYHLENAFTKYHNEVMEGKKKEASGTAVWPCRLKTIACFAKRDPIILGCDIIDGSLRVGTPLCVVKTDPTTRKKTVVHLGKVTSLEINHKERDVVLKRDVGGGVAVKIEHAVHESAKMFGRHFEENDVIVSHISRASIDALKAHFWDGISTDEKKLIKKLKGELDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGN5</accession>
    <name>W3VGN5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_06215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227281_0_0_1"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000796">
        <property type="entry name" value="Related to siderophore iron transporter mirc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="758"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="900"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="963"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1060"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1174"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="693"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="642"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1409"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2222"/>
            <end position="2251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2554"/>
            <end position="2602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1207"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1409"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2222"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2237"/>
            <end position="2251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2560"/>
            <end position="2580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2584"/>
            <end position="2599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS59891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2709" mass="288469" checksum="409E53E924A00213" modified="2014-03-19" version="1">MCLKSAPCQTSQRPETEPLDLTLAWDARKSEYCKIFGVGFWILDFGIGEMPTNRVQRSKRVEQRLDHVAQSLAPRTRACSLLLSSLSPSPTLRHTPGAIPALAPPSDGSLERIALHFGLGSRPASSSGSPRPHTPVIGSSVASSVQHEPCVFRASSSLDSARTLLDARSDRLPRASPRLSLCEHERTDPHGGHYHCSSAVGVRSREHSSALASTAMLCATTGWAVNKLAAFVFPLQLADRPRSTLDGVVPPEAPSASAASHALNAGGPVPIKAPDTVAFEARYWPLVHPPRNNAEAQQLYNHIRTVAWYLDSIPFLGSRLPFNVGIESILGVIPGIGDYIGLALGLYQILLCSLFGVPLSLLLWMLVNVVVDCIIGIVPLLGDALDILFKANLRNLRLLEDHLYESRGRCGAGVFYIQFPPNDVFLTPGRSGTASQNIARPSRVPLNHPLAPSPSSRTSTPTFYLSLPASVAGPPGSKGSDPAAPPISAPRRPQASSEKEDATSHASTSPNLPMKKADTAVASAQVEAYVIPEGSSTSTRHRDTMRDYSQGVSSAQAAAPASEGSNAERAEYGASAKSRADPAPSRHRDGLPSNHTASSATDSAVNVGKQPLHSAETERPRVSWSDAAWTARSQLLKADDKRPSLDAFSDDGSDVNEEAEDQRLLKPGRLEREQDADDARALWRKRRGLYLLVYSAIFCVAYVSSLDSNTGYLYLNFACSEYGALASFSTVAIVQQMVFAIAKPPIAKLSDVVGRPQAYVLSLCFYVCGYLIVASTSSLRSLIGGICLQSAGTTGIQVLQSIIIADTTTAKWRGLVIGIVNLPFLINFAVAGPMVDLVMRHGGWRFGFAIWTVVMPLAATPLLLTLLVGQRRAQRAGLATRSWLRDKPWRSALRQLATELDVVGLLLFTGGWLLILLPLTLAGHGERQAEVPMATFIAGGVGLLLVFGWWETRASVPILPYQFLTNSAVVCTCVVGVLDFASFYISWTFLSSFVQILKGWDQTRTGYFATTQNVTSTITGIVVGSLMAMTRRYKVLLVIGLVVRLLGVTLMVRYRTAEDPTYMLVLCQLLQGIGGGSIAITMQVAVQVTVRHADVAIVTALELLTTEIGAAIGSATAGWLFQTYLPAKLAANLPGMEADELKLVYGSLQKALSYPLGTAERDGIIRAWVEVMRMLSIVATVTLVPAVLFGLAIPDTALPDVHGGAQSHHHHHHHRHESHHHHGSRRGDRRSVRRRPSFLSTSRPSSPLEVRAGYADPTLAMGVGASAEGNATAGFLSAAGAGSKRSRSVSRNRAGQPLKAQRLAPAPSNLLLLIPIPIPILILVRTDRLGKSSPLPVCLLSTRADQPPILDTRSFLFQAGKLIFHSPPTLLGLKTLARRIARSIALAQHQAQLAQANAAAELPPMADPFPSLLSDPFPPQQSQQPAAAAAAAVAPASDAAAANGANSNGARANSRSKQPDLASEAAFPSLGAAANPAKGQWGAKGAAPVSTWAGSAPVIQRAIAQQSFSLSLSHESVTKLSTVMSKVQNKYRGVKIEASTTRKTGTTTFVLKAADEAAIKSAKREITVLLAKHVSTHIMIPASLRAFVIGTKGKNLKAITDSTGVKVTIPPRDPNADNDTANAAAASANIDYENDEQIAVSLEGDEINVKQAQAMIQAIVAERTSKITQRLTHIDPVFYPFIAGPKGANVAKLESNAGNTDISVRVPPRAAFLHAKDAQDDDAAAEPKRERDLAIIVSGDREKVNATVAAIDAQVDAMKSSFRTLAISIPKRQHRFLVGDAANDILAATSCSVELAAIDDPSDSVTIRGPQTQLPMALTAAMEKANAVRVEVVDVVAAHRQLTQDPVSHAKHILRWLNVGAKIPRSSTAQIYLPRPAIVESTGNVQIEIVGSDPAEVSKLRESVSELVKAVPPAFVEQIDVDPLLHRFIIGKKGQGLKQYEARGVDVLFPPASASADGDSRSDVLLVLGGSSVVAALPADRKAREAKARDILASVKDDIQKAQVAAADIRSETLTVPAKLHRAILGPNGTTLNAVIGEERLVAVRLGSSKASASADKPGSSLSEDSILVRGPSSEVDRVVKELNRIAAEAEQDSIVNGHVAQFSVDANHVPHLVGRGGSAITKLREELGVRIDFDEPAGADAPDALKKGKKAAATKKVVLTGRKENVEEAKRRLQTQVERLADETSVTLKIPQEMHGSFIGQGGKYVTRLQDTYAVRINFPNANAQSSGQSTPTDNADDKAAGARASQKPDEVIIKGGRKGVEGAKAELLELLEYEKENNNVSILNVSTKSVARIMGKGGATIKQIRDDSEAQVDVDRQDNEKDGTTPIKIRGTKKALAAARKAIEAIASEVDAEEVYTLTIAPEHHGILIGPQGSNIRDLIIKAGGPEDAKASSQYVQFPRKNDKDTSTVTIRGPAALAKAIRDELKSASDELASRVVYGVVVAPQAQRMLIGRGGSRQSELQTQYSVRLVFPGWKEYASTGEPVNKAELTGGDDATIVKIVGAEDRCQALAEEIKSSFASASKSIDVPRGVHARIATPQFFRQLRSDFGVSVDTPKGSASASTSAPSAKNGAKAAASARIDDVDDEDDAENEFELEELSSASASDSVTWTLTGKDEAALQKAEKRIQTSIKEAGNASHQGKLWVTPSAVPRIIGRGGSGLMNIQKESGAAIEIPRDSGGLCIIRGSKDAVMHAKELIENAASSSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGS9</accession>
    <name>W3VGS9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_04775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGS9"/>
    <dbReference type="HOGENOM" id="CLU_015166_10_9_1"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="230"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="341"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="467"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="184"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="61568" checksum="7AAD84A2A63B393A" modified="2014-03-19" version="1">MSLFAKRAGSGVTPGSAGPPHNSRGSQGRGPWHGMTIMIASLSSSQSLTGASSRTAHLAASINTGLQQQRDAALPVRKAKVIDPSPQQRSLRASHCFFIQQQHSAGTMVAADSASWAGLTRSSQASTSAATLESFLNTAASLASQAAPKLDSPPIARFSPGARTAAASASAVAEVSNPTDVARARAYQQVHSSDSSKTTPSYTSSVSSSSYKDEDEDEGEHHAHTATNHAFLITYFVAGGAAGATSRTVVSPLERLKIIMQVQPQSSKAASVAKGKASSAAKNRAYGGVWTGLVKMWQEEGFAGFMRGNGINCLRIAPYSAVQFTTYELCKTWLRNDDGDLDVVRKLTAGAVAGIASVVSTYPLDLVRSRISIASANMYNEAKSEATSQVSAKVSQEVLREQIAARQKAVPGIWQMTSKVYREEGGLRGLYRGCVPTSIGVAPYVALNFYFYEAARKRITPLDGSEPSALMKLACGALAGSISQTLTYPLDVLRRRMQVAGMKDSQEKLGYKDKNAINAIQNILRAEGVTGLYRGLLPNLLKVAPSIGTSFLTYEAVKGFLEVHFDELHPPTPKETSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGU6</accession>
    <name>W3VGU6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase C15, pyroglutamyl peptidase I-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGU6"/>
    <dbReference type="HOGENOM" id="CLU_043960_1_0_1"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27306" checksum="693D1712897F3DC1" modified="2014-03-19" version="1">MPAVRREVNVLITGFGPFMSVVSNPSWLSVKPLHNVRLSSCDASTSAQVGEGVRIQTLQVPVHYSSVLDLVPRLHGRTPSSGSFWLDPRLDSPYGGTAGQAYPDGYPIDHPLTGFDVVIHVGVGRGGSIRLETLAHKHSYDKPDTASSLAPALSDKKRGFGQGYEQFGDIQQTTVNIGELVAWLKRRGLEVDQSWDAGRYVCDFIYYASLTNATGAKVLFIHVPPVEDGPGVQKCTEVISNVAWWIATQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGW9</accession>
    <name>W3VGW9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGW9"/>
    <dbReference type="HOGENOM" id="CLU_039744_0_0_1"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="365" mass="38153" checksum="838ECD2748FF53DD" modified="2014-03-19" version="1">MARNIVTVALLQDAAASTSAVLDALAGAFSLVERTTLRITLPDDDAMLRALLAHEIATLGEAAALVRWAPSFTAAPCSLLVLALTSNDDACKVFLTHHASSLDKFGPIYASPTRDVAQMQRTLLFSAIGSGSSEAGRSSSTSTRATSVSRASQPGFKARAVPSSVSSKPTIEPRLSRAAALRMGVPLPTRTPSPTKTPAPASGMPRRTVPPPSSLRTPTIAPRLNKAALARQNQPSQARPSTAGERVRSQVDFSRTPGHKRASLSTSVASTAPPAIVPRQTRASLSRLSTHQPAVSPGRPQAARSMSVGGPRAQVDFSATPGHKRALPIAVASLKPPTVVPRQNRASLARTSAPAQHTESPLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGX9</accession>
    <name>W3VGX9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGX9"/>
    <dbReference type="HOGENOM" id="CLU_1644445_0_0_1"/>
    <dbReference type="OrthoDB" id="10600632at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="161" mass="17273" checksum="86F1A44FEB04BD6A" modified="2014-03-19" version="1">MVIVSPAQKASQARIRNQGLLEANRRKVFYDDRPVKLPSPLNHAGPASASRLIADRSDCTAPMGKFSQELISKIAHKTKPKKKPGQNVPRGSSPFVMRSLCMNLLQDLAPHLAPLSWLDASSPTQRKTLGAKTGRKRLSGSMLDAVPANALRLACAAALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH05</accession>
    <name>W3VH05_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005737_0_0_1"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002916">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="4">
        <location>
            <begin position="890"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="597"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="781"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="829"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1251"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1252"/>
            <end position="1271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1373" mass="147856" checksum="9CF8B8BFA902198C" modified="2014-03-19" version="1">MSSSWIKTLRDRAAQAGSKVPERLYHTDWSRSLANAHLSSAGTFNEGLLAGLALPGEATVMAFEPVRGFLAVGTTLGTIHLFGSPAVQLSFSLRPAHRVNHLAFKSDAGLLVCIDEKDNISIYDLARPDPQIRAAHGTSSNQYRPSSASTGHSITGPPHPDTPQRVGVHSVRNKVICVEVSSAHSHMFLGLRDGTVDAYDLERMCPSPYRVPNLWWEEEEILRKSGVPDAPNRRHVPLIIDIKTHPKDINQLLLAYEGGAILLDVRERAVLKTFQLRLLPGARGAGGHPDLMWTERAPPATCVAWRPDGEVFAMGHEDGCISFWHARDDDKPLMVRTLDCLDVDKPITDPSLMDVPRPPKEPIFKLAWSGFPEKSWMSMASESAASWQSQPHQRTSSSNEPVDEPVKGTLLTVLGGAGPDMDMPGLFCSNLPPYAAALTLWVGANAEASRKLRQALHDSLVPTSETVCPTSSQVEDFVLLPRNNPHYSGSYDPTAVVVLLAADPALPTLPPPAAARGLACFAYPPRTRSDSRAAPDPQAFQPGSNSVPIEPQKELHLPLPLTLAGPGAILGAKLETLTPHAYRKLVGPLDVTGLNQKQEQEASGSALRSSFNHEKPPLELAGGKASGCLSGEGSDGIPELLRSSSFRILITWHLDGSVRFYDASPHLLLMGRVDEDDLKRQLASPRIWLQQSFPSPLPHLTIDARALLHSPAMQGHATFDRIRARARIQDVQFATEVLEASVVLSTGQVLHMRFGFAQLSETEMINDEVEESIKRQEEQANLLIPPVKSPRGSTHRSSVSIASPRSEAAAATSQALDAEMSKAMQELEVGTDAAVSSSGAPPPRPRRDPKRASLNPGQRGALQQPADWRTTSPAGPAPAPMQPPPGGFEAEEIVSLHHLADPRYDGFKPNLMVDPMRGEITALASSDIGFLAVACGTALVVLDFRCGELILKEGFGGHESEQGGHGDAKTLRKAIEAESKSPIVQLRFSVCRIAEDPSLAPRLIVVRANGVTTVWTLQRTLDMWLVERSGTHKLEELVDARGLHVLDTKGRACDAHPQDLQRALREQEVGFAAGSAAELPEADVLLGFSERQVTLRYGITGPVVSRAEMGEGVLGCSVVERAHDKVAAVVTASSIRLLSLPKLEPIVRLQRHHREVGDSAGWRACISFDANGDFVEVCSSLDVRLWTMFASLRRPGQPNLTLVDPTAAPTVPLHPGAVGSAAGVATSIAGWFGTKTTGVLSVGAQMDAVLAGDKRPEPPKLGEALAPRDYRPPLPPATETDRVETSERPTAAGSSLGGARRDPSRAKAVAASADSAWATSYQNIDLLKARGAMMSGIEDGLTNLERGASNFLKSTREAAIKGAAKDKLNKMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH15</accession>
    <name>W3VH15_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_06087</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH15"/>
    <dbReference type="HOGENOM" id="CLU_034386_1_2_1"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="341"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="405"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS60092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="444" mass="45660" checksum="2C41EA2C597B67A2" modified="2014-03-19" version="1">MPSPPKPWERAGAGAAADLSSSSTMSSSAASSSALATTSAAAPALPERPSTLGASSAATGAYGASAYNSPYRSTVGGLGSTYGGMGSTYGTSYGSPYSRYGGMGGMGGMGGMGYGSYGSYGGYGGYGSYGGYGGYGGMGMGMGMGMGGMPGMPGQPGDVSLTQRMEAGTQATFELISSIVGAFGGFAQMLESTFMATHSSFFAMVGVADQFAHLRTYLGQVLSIFALARYLKNLGLRLAGKAPAVELDAREFKEFAAHGASGQPGKAARPSKRPLIVFFMAVIGLPYLMGKLVRFITAKQEAERQRLEQQGHNPGQAGLLPGQHGGGMIAANENGEPIDPSKLTFVRALYAYPATDPLELSLQPNDIVAVLSKHDPQTGAESAWWRGRTRDGRIGWFPSTYVESLESAKERATKASAASNTTKAADTADKASAQPAKPATVKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH42</accession>
    <name>W3VH42_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH42"/>
    <dbReference type="HOGENOM" id="CLU_012062_23_3_1"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="92"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="202" mass="21958" checksum="270E19C0AE38160C" modified="2014-03-19" version="1">MSAREEEVSLSEPGTSELASLDNNHTGEASAAEGGENTAMTDEDAEIEAMKQRVAEMEAEAAKLRELQQAAGEAGGAGLHPSEEEREEVDSRSIYVGNVDYGATPEELQQHFQSCGTINRVTILCDKFTGHPKGYAYVEFADLSLVANAMVLNESLFRGRLIKVTAKRTNMPGLAARGRGRGRGRGRPFRGRGRGRGRGYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHA0</accession>
    <name>W3VHA0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHA0"/>
    <dbReference type="HOGENOM" id="CLU_852920_0_0_1"/>
    <dbReference type="OrthoDB" id="2554947at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="313" mass="34024" checksum="657ACC88F01E7C83" modified="2014-03-19" version="1">MIDALVGLNNLTAVIRTDSETLAAYVVSSTYASAATGLDSRIAKDVDSRGKREPIRPEPHGKSDDQDAGSWTLTVGSERGWWGTTLSPGPLEEFIDRHRHTVQDHPGDSHRDKLACKISNAFARQRILCGVPRSWQGDTTWPSIRLYFDADTSPIHLDLEQLSLKAALLHSTRLVLSTAPLANLPSGSSFAQHQLQRKLEATQQALREERHKYRSLLAAPSAAGGRHGRRPVVGLGSSQRSSALPSSSPSSGSRSYGGNAPSSDDTSTVSSQPSRRGWQRTLSLVNPTRVQRADPSENDDFVGDHDDDGELDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHA6</accession>
    <name>W3VHA6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_06104</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHA6"/>
    <dbReference type="HOGENOM" id="CLU_288707_0_0_1"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000092">
        <property type="entry name" value="Related to white collar 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="601"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="250"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="941"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="945"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="991"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1017"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1047"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS60106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1091" mass="115067" checksum="70FE6FA4FEEF123C" modified="2014-03-19" version="1">MMADTFDFDAFISSPSQADVVAPPPVAPTNTTAANPASDIFKINGTAPDPSLLGAPSNDMASSFSDQGLNGGIDMMPASSLMGPSDSMMYATDYSESFGNDLMDAWDMNDPANAANPSSAFDFGSVNAPDSVAPSGDAALNGLNASPFVPRARNGQASMPMASAAAAASPAAANAAKTARDVTSSYRDQIAAHHSQLMSTSTNSGVHGGGSRSTSSIPRVTTFRRAQPPIHRGVTAPNAARANLSLQERRRLSRQAAKQQGLHSAHAQHANSAMAPGAPTSAFTPMAGRGAKRGMSSDDGHISSSPLQPVPAPPTRTVSFMNDSSGSSVSSTGLSPQKMLDSRASSFMHNGAGPLGTLAGGLDQAPSSVYQGNFNTTSGEAVATANKYSTSGVDVLGILSRAITRPNPSIALGPVDLSCSFAISDARHPEQPLIYASETFCHLTGYTLHEILGKNCRFLQTPGAALEAGTERQHTDNRAVEHLKRHLTGFRECQASLINYRKDGSPFINLVTVVPVSWSDPGQVDFLVGFQVDLVEQPGAILERKEDGSYLVNYRSINDPPPSAIMGSEEMTKDADAEASKQAAIAADILDLMHGVGPCDAKQWSRVLLENSHDLIYVLSLKGTFLYVSPSIERILGFTAEEVIGKSISEFCHPSDVVPVFRELKDSTSNASIAAAASRNIRTEGVANPLTKGGGGQAGPRVNLIMRMRHKHDGHRWIESTGKLHLEQGKGRKVVISSGRPRPVYNLAWEHVRRGAESAQPSFWSKLSIDGIFLSTTGPIAEVLNCDSKDIFGRHLLELTNYEAAPSLLQALRSSQAMSVSHFMGDGATNTTPVFSSFYPSSAAAGPALQTVFVHVQRASAESSWMIPNVAYPKGGPQPAFDTTGTSVDSLTSVFAELSTYRSSSWVFEMHQLKNVNRRLKDEIRALRRQSRDHFGGAAGGVATNGVQLSNPQSPTSAVAGGRRHSAHMEPMSFSNGQVSAVPHIQTPSPIKRRPDHGHGHRQHLRPSATLAYLHAGSSTDRGSSSSSGSEISPFGERAPNERRSGSGDASDETAATTTTSGDTSEKDGSNHGSGTGSGSESRRNSGSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHE6</accession>
    <name>W3VHE6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_05681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHE6"/>
    <dbReference type="HOGENOM" id="CLU_001485_12_4_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="322"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="182"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="416"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="686" mass="74389" checksum="C107E5A0DA32FBDD" modified="2014-03-19" version="1">MSSIPVPQSVKRQRSTATLPAAAGPSKLREPGAARTVAATRSISTADNGRFVPARRTATTASAGLTLPRAPMTNTTNRPAAAAATRSVSASKVAPSAAARRGVTSVTRLRPGTNAAVAAAAASRTSNGSAGSAASGDVDPSRMDAMESRLASMAELFELERTKTEEKWNKERSERLAQEDKVRQLEEDLLEQRKIAQSKQEEIKRRRTLADDEMLQLTAKFNREKRLLETELEQERETVAALKATLNQQSTSHLTMESTNTALRSQIQVLQDEIETLRSRIAGMDADVAETKAANAHLENELREAESLRRKLHNEVQELRGNIRVFCRVRPPSNNDANNGTEALATIRFPNEREANQIELLAAAESATGTVTMRNHLFSFDRVFQPSASQADVFEEIAHLTQSVLDGYNTSIFAYGQTGSGKTHTLEGAPDSITGWGSNPAADAGAGLIPRAVQMLWSTAESLKDKGWRYDFEGSMLEIYLDNINDLLGKSEVDKAKHEIKHDKGRTSVSDTVVVPLDSPAHVFALLDKAKKRRQVAATLMNERSSRSHSVFMLRVRGHNTTTMEACDAVLSLVDLAGSERLANSGSDKDPVRLKEAQSINKSLSSLADVISALGQNKTANHVPYRNSTLTWLLKNSLGGNSKTLMLLALSPMAAHLNESLCSLRFATKVNSTTIGTAKAVKSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHH6</accession>
    <name>W3VHH6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHH6"/>
    <dbReference type="HOGENOM" id="CLU_1627787_0_0_1"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF25">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834174" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17534" checksum="5487505F08A81CD2" modified="2014-03-19" version="1">MKFTTTVLALLSAAAAVSATVDTNESGLHTLGERSFERKARHVELSARAVESSSPDLESRDWVSKWGKVTWYAGGQLDNPACGGPTPTDDSAVVAVKKNGGYGKCGETVHLHYNGKMVSAKIVDYCAGCEWGHFDATRSVFKKLAPLSQGVIEGIHFKLFTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHS9</accession>
    <name>W3VHS9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05547</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHS9"/>
    <dbReference type="HOGENOM" id="CLU_013325_13_1_1"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="337"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="421" mass="46750" checksum="E001123863907B23" modified="2014-03-19" version="1">MLHSPARYQHVDRLLDRPGPATDAAFQAGASVKHFLRTQCKILVIGAGGLGCEILANLALSGFHHIHIIDMDTIDVSNLNRQFLFREADVGRPKAEVAAEFVRRRVPGVDITPYHGKIQDKDEQYYMQFNLVICGLDSVEARRWINATLVNMVDEEDPESLKPLIDGGTEGFKGQARVILPTVTSCYECSLDMLSRQTTYPICTIANTPRLPEHCIEWASVLEWPRLFPDTKLDNDNPDHIQWLYDQAAARADSFGITGVTWGLTQGVVKNIIPAIASTNAIVAAACVLEAFKIATTAAPFLNNYMMVTGNDSVYTYTFEHEKRPDCPVCGGESRTMSFKQHDTVQDLIDRLGEMPDLQLTRPSLAIQGRPLYFQAPKQIEEATRPNLGKRIAEVCTEGDEVTVTDARLPFTLGVVVKFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHU4</accession>
    <name>W3VHU4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05827</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHU4"/>
    <dbReference type="HOGENOM" id="CLU_018632_0_0_1"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="508"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="774" mass="83234" checksum="26E8AD3D550372CB" modified="2014-03-19" version="1">MSCWASSSASLRAVAPRLARSRAAAATLPTQSLAARPATRLVAAKPPTSPARLFSSATAARANTSVSGQDLSIALDDNGNIPAAPYSPLPLAGTSPSYKVHLIVHPYDHARPADTWPSHLESVSPFLSELESRAKKGGSLEGYGISFSAGDARAVSSSEAGLQAWDPSTSRMMRAVPNSAQEDERFVVHAYTTNGTMAKIGPVSLATLDNSGAFRQRIDDALAAAQPQTGRAKPDDETHVYVCTHGARDCRCGVAGTAVLQALKDEVRAHQAAAIKTGKQTPKNVRVYPVSHVGGHAWAANALVYPHGDWYGNLRTTDSKLVLRAALAPASSAHDLEDMRERLVHWPRWRGRLGLSKAAQRDHFAEWGPPTVNTAHITPRSRGLATASRAALSSSSLSTSSAASVRTYATDAAEKAKPSARMQAFREKLAADLSIDDFAAGDVDPLLSSAGRVQMGRVGEARLPKHLKTQIPTGANYTRIKSDLRGLGLSTVCEEARCPNIGECWGGSGGKDTATATIMIMGDTCTRGCRFCAVKTSRTPAALDPHEPENTAEAISRWGLGYIVLTSVDRDDLADGGAAHIASTISKIKAKSPKILVEALVPDFSGDRACIEQVAQSGLDVFAHNVETVERTTPSVRDRRAKYRQSLAVLKHAKTVKPDLITKTSIMLGCGEQDAEVEQTLRDLREAEVDVVTFGQYMRPTKRHMKVHEYVQPDMFAHWQKRAEQLGFLYVASGPLVRSSYKAGEFFIENVLKQRKAQQATAPVDKHNQLRPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI71</accession>
    <name>W3VI71_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI71"/>
    <dbReference type="HOGENOM" id="CLU_002631_1_1_1"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="7">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="6">
        <location>
            <begin position="397"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="661"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="316"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="739"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="675"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="987" mass="110299" checksum="E1B848ED6CF4813E" modified="2014-03-19" version="1">MPLVKRKVVELVPPPIASGSDDPDVFYLAQTGELFPDFESYSNRLTFYNQKIFQCELTGRINLTYFEALKSERKEAIALHKIFPEQLKAPVLRAVQFQITGRIDELVDLVYDRFKHRFFPGETVYFDLDGDKYYALVSHVKPPPATAPAPANGHDAEAQIKQEPNGHDAHSSHSSPRSSPSPSPAPIHTVGTDLALELDAANQADDPANYVYHVDLIDDEDQPTGGTHVTSSEKLSRDRLAFSKTILRKYLRDCIVRAANIGAEWRVKDWLARKYAIPLEPTDEITQKNEALKDAKLSKRKKYLLVDGDDSGTDSSKKLKKLSAAAQRKADAAEQAALEKAKEEERLRRKNLKYPIDDLELDPITKRELMVKVPGELERRKQRPVPGRGSLALPVPGELFELFIVSYYFLVSHGKPLLLSTFTLDDYEQALQHRLSDPPCTLLNEIHRTLINLVVRDGGSSLVSATSALEATLDLPASAPASVDGDEDDDHARSDAASDVDELDASPNGASTNGVAGTSGEAAAIASLLEAARELSAGWETLVVRADHRRERWENSLVGLIAARATPDTLPNMIGILSHLTAVEHADGYIDGEWVAELYDSPAQRYPLLSLKDKLHILDFLCSQAVMTRAVKTFYDECEAQVTELRKDKIELSRERKRLAEARDEFEGKHSKDDADGEGEGDAEAGEGEEAEAEEEEEDEEEEEDELVSDSERSAREGSSFSDGRGGRGGGSRQEILRQKALEKRAHEAAQRMEQAKARELHRAKLAENKMLSAQRRRLDEDEARLARRDEMLEREFRRLLHVARMVPLGRDRFGDKYWWFDGLGSCSLVTASDKPTYQTGRLFIQAASSDETALLLPESDVKRDAYAELLHPTLTAERLEERKEAELGQGGVLAPGEWAVYTEPERVQELLAWLRPKGHREHALKQHLLKFRTHLEGGMKKRNADLGANLKDAFDAVRRSARAAKSDANSARLAYMTWKNTLDKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VID4</accession>
    <name>W3VID4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VID4"/>
    <dbReference type="HOGENOM" id="CLU_065163_1_0_1"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="338" mass="36578" checksum="8A8D1E87B3F9BE5F" modified="2014-03-19" version="1">MPTTVVADATTSLDGTALAAASSSKYKPTTVDEGATPFQFDLGLLTSINPNPVSSTSADALRARARDGVQSLINRIFVLPVTRDAEYGPLAALPAFASRLPREKSMPKPKPLTKWEKFAKQKGIQSRKKDKMIYDEATGEWVPRWGYKGANKDLEEQWIHELKNNGNTDLDPAKTAKKDRLAKQAKNESQHQKNVARAAAASASATASSSKGGLGDANAAKLARAAQRERRKAELEADVLRSRASTASMGRFDKTLKGESKAKGIKRKFDANEKDAAAERENNLALLNKLGTSSMRKRANAPGQGDAQLVNSRKAVHFATNGHGVTSMAKADKRRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIQ4</accession>
    <name>W3VIQ4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004654_0_0_1"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="343"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="944"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1265"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="629"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1441" mass="155216" checksum="8CD61DAA7845EC27" modified="2014-03-19" version="1">MAQSRPTLAPFCLAAIIDTTQPTIELRDCSVQLDTTTTSSSTLQAWCQGLSHLLAASLQPPRKAGGDASQLPPTWRRITMAEQSSPASERITVTFAASQPLLAAPLAPHFINLLQQQLPLRNLHWRPSQSTLDAVAARAAQQGKPAQASSSLAPGSTIRTIQTLDVALKPLTDEIRRWRGDPGYFEQPGGAGLLDRPFVHLYLVVCEDSEHYRTTVRNEIRSWISSLSFFHARQPGVGANNPAPGTPTLASSSRTSLGLGSLRSATPPVRSDTPPATASGPQTPTTSAAASKATLPASISIVPTEPEYLIVLITPPEGAGISGLANATPAAEAKTGMGRFMNKSKANVLEKARADFSTSKKEHVVHISRLPPVPAVPLTRSGLHSMDPTIWAELLTKMREAASATFTTTIEAQEHEIARCGVTKGQQGWDFCSYFLAKDSLARTLDAVGLKDDAVGQYEDLEIVFAQAMQTGAVAFAPIGGDDANDDSLPLLDVHKKPYAELIRRNEISLFDFRCYLFARKSALLGKMGRVAAVMREAPLFIAAVGRMLRRNPRLGSEWIESWIFSAALDVVEQCQAWLIQRSAATSDQGVDQLTPAFQSNKSELLDLARRQLDRIGIQAGHLPELDPFVCPSDSGATDTARNRDLPALPDDASGEGAAGLGPALQLDEKRMPSRPELKQAIESREHFDSHYLALCERIAAGWKAASRHRDTLHVRLVMAMLRYLRADYAAAHTSLCTISDAYATARFSLLEAHALALQLECHAQLGLPRDRAWVAAALAVLRASVQTRARAQIAGTEAAKWTDPAYVCDELRRASSAMEREIPVSGFPLFAIVVPSGTAQLVESEDGSVVTVDVTSMLPCAQLVQDVRMCVVGKHAESLWYTSGSTTLQPGRNRVELFNAHPAHGVYTVDVTQIRLARLIFQYDAAAAVPTVVRVPKDGAAPSVALSLPRRIHLDRTREVQVTVCAGRHRIDSVEMRVGAADGTALVDYSSVVAQSEAPATEAAADCVSLTTLRSDEEVRFTVPLLHVPESGVLDAVVTLSYISAAGERALGKKRVLTTRVQLRTALPLGVNVQDFFRTASLLSKFTISAAGAGSIRLQPVRLDHDGDAAGTLEITACGSARQATVTPRQPATYLFRMVNTARPAERGRLRLTVNYRSLHEEAVSLAVGALQTQSWGMEATRLVQQALRVYVGERVDLPAFSITGGVRTGEVDAAWWRTEWRTWGQAPASFADVLATVTRALDAVASAARDGDVDDTWQTLTIPVDVPSVEYVNAVTLNVGAPLSDDTALVVGQPVQLTVAITVSRQWATSAEAAKMIWDVVPDFETWLVDGQKRGSFAIAASEQEASVTLTLTAVPLRTGAVALPHVVVHPLLPEHQQASCETYITNAAQRITVLPAPTTTAFFLPTSSPVPNTVSQPASYESAMWLPYQAAQPSHARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIS7</accession>
    <name>W3VIS7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIS7"/>
    <dbReference type="HOGENOM" id="CLU_012066_2_0_1"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="99"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="666" mass="76250" checksum="EDE61B370C99E61C" modified="2014-03-19" version="1">MAWIACTDPEAFDNGGGKPIQVCGYGIDLRCHVDNEKAFGSAVFPERLSNRLTVREVAMIRVMEALTDKLDWQRKVNDAAIVAKWKAEALEQEPHLSAQAFDWCILELRDKALYFQRTGLIHALDSENRCVKSDVLLSSEVLTNLRQAVRPLLDIDPARKDWHPRSNDQVLNLVHPSLFPLVYGRSNFLPEGSVGVEDCVDACGRGTPFPEQSKPAPPANTWPRSEEHEIAEFYSYRFQWLPCDVYFAGESGTDVRIRSYINNLEPKRNRQLYGLIEKAISASIEPWNQVLLRGPFGRVPLRIQCHSVDCEPDDEPEWFRGLLDDEDQDEDSDAYRKAFAKVQEYFSLPDDPEMERLEGPCQSVEDAIEEAGGLYGAALMKYRRTRHVIHPEPGDKEAYLHWRPLDESTHGAKAHAKKRQKREPLANGYYEVNIEEEFRSRGLQVIVKLASIELSPDKPEYAGGSWHVEGMMNEHIVATSIIYYDVDNVTESRISFRHNAELDEVETEHEQDDHSPLCIVFGTDSLREEPRVQELGSIATPQGRLLAFPNTLQHRVEPFELADKSKPGHRRFLVLWLVDPNYRLASTRNVPPQQREWWESALDNPTAGSAIRSRLPAEIKESIMEHVDWFMDLDEAKALRLELMDERTKKEQASESQMGTYNFCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ13</accession>
    <name>W3VJ13_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ13"/>
    <dbReference type="HOGENOM" id="CLU_101473_0_0_1"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="209" mass="22436" checksum="2A10BFD3505C0383" modified="2014-03-19" version="1">MFFSRTQEEPVEATGSASNAGGGGAATSVPASASAAASASTGEWETKGAAGLGAISSMSAECTPLKHRYDSCFNLWFKDYLAIGDDQIQEQQRRSQTSSTASSSTNAAGTKKKSGWFSDSSSSSTSTDASSMADSDVEGRKNAIMQRYERDCAQLFKDYQACIKKAVTERGLDDLIRQARKENPFPFDHERRSDARANNPPFPFPAAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJC0</accession>
    <name>W3VJC0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJC0"/>
    <dbReference type="HOGENOM" id="CLU_019533_1_2_1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="93"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="401" mass="46090" checksum="00913AC48F33DAF3" modified="2014-03-19" version="1">MEKLGTNSDAARERLAWLNSKEAKQIQSKNKRVVLIGVLLGIAAMVAVVLDGVLRVEKQDKLCLVLDDDFSKGFNKSTWSHEIQLGGYGTGSFDWTTDSEANTYVEDGKLYLVPTLTVQNLWAPYFNLDGFKLDLTAAGNCTSEKDTDCQAGNNFDEGRMVNPVQSTRITTKKSFSIRYGKVEVRAKLPTGNWLWPAIWMMPRDSAYGEWPASGEIDLMESSGNMPRHRMDQRATGSVQSSYHFGPDWRSNAGGHHTGYQFRWRNYFNQGYHNYVLEWNEKRMRVYVDDPRTTISYFEFPKEPMWEYGKFGDIQLDPPIHNPWIRSENPNIAPFDQHFYLILNVAVGGKYFAGTDDVVWNSESAFPATTFWQNVKKWYPSWATDPRERGMAVDRVRMWQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJH0</accession>
    <name>W3VJH0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004765_0_0_1"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="976"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1141"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1247"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1314"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="912"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1348"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1379" mass="151365" checksum="EE7DF686EF17FA64" modified="2014-03-19" version="1">MSPPRVLTIAGSDSGGGAGIQADLKTFLSLGTYGLSVLTALTAQNTTGVSAIHACPPEFVLQQLESVSSDIQIDAVKMGMLCNEGIVGALAKRLGEWRQSTGPHGGCNVPIVLDPVMVSTSGSLLLSEGAIATLIRDLLPLCTLLTPNLPEARQLLNYAAKFTSHQSATRELDLAKENEETELPQMMAAARNIAQLGPRAVLVKGGHAKLSRLQIDEYLSNRAETASAKVEKMAPTSVPSISRSSGSRYPQRTKSRPADAHQGRIDNEDELRQLAGVDGAIITRKGNVTAIRTDQIPFSDVLHQRPASPGADDKVVCDVLYQQGEDGTDGTFVLFVKPLLASSATHGTGCTLSSALAASLAQGHSLVRATSIAIKYVQNAIACGIQNLGSGPGPLDHSYPFQPRGLIASPSDLGNGELSLHRSLIANSLDAWTGFVQHPFVLGLADGSLPRDGFVWFMKQDYLFLRHYARIWAQAAASPDTTFDEITTLVDMSRSIAQEAELHKRLCRESLDVSETELEHGTTESAATLAYTRFVLDTGRSSDVLDLLVAVSPCMVGYAQVGRWLAHHRSATLKQDYVEWIEAYASDDFQQAARKAMQLIEARAARDDLSPDRMRKLQRIWNAACRLEAGMWDEAIDPSLRRPPCEPPLVFSLIDIAKTELAALASVSRNAIHRFESHCDLLLFAGVIPGKNLERFAKYSPTVQAGGRQKGAKPSEQRQFAAKFRRSMHPQLPNVIFGPFVLHPSLGSTVLGPSPKPDRSCPPQATLLELKILSVCRLAARFVPYPTHPLFPSDTLLSSASSYIRLVSIMADHAAPSRASSSEAGTAIATPHQNPDKTKDTTSQSSEPSQDDAPADVQAIREKNDLVKTNSEKQREGEHDLEPRDDGKIVLSERAGYLATGYSYPTWRKWAILCVIFAVQVSMNFNTSVYPNAVTGVAEKYGVSEPAARVGQMIFLVAYAFGCEFWAPWSEEIGRWPVLQISLFLVNIWQVLAALAPNYGSLIVARFLGGLFTAGGSVTLGMVADMWEPDEQQFAVAFVVLSSVGGTSVGPFIGGFIQAYLKVEWNFWVQLIFGGAVQLVHFVLVPETRSTILLDREAKRRRKNGEKNIYGPNEVRTDRFSMREIGKYWLRPFEMFVREPIVLFLSLLSGFSDMLIFIFLESFQLVYKQWGFSTVQVGLAFIPINLGYLLGYLIFIPRFIWERKRRVRDPDALKPEARLWLLLYLVPLETLGLFGFAWTSLGPPRVHWIAPMIFSTMIAIANYSIYMSTIDYMIAAYGPYSASATGGNALARDFLAGVSAMYATPLYNRLGLEWASTLLAFLAIIVAIPVYVFYVKGPQIRERSKFAQSLADDRKANGGRRTDQDEKAERGETYKNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJJ3</accession>
    <name>W3VJJ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJJ3"/>
    <dbReference type="HOGENOM" id="CLU_013572_4_0_1"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000051">
        <property type="entry name" value="DNA2/NAM7 helicase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000003">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="98"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="291"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="689" mass="75255" checksum="FB00720ABFCC1219" modified="2014-03-19" version="1">MPVATEEKAFGAQDFIAFDFGADQAEDVPQSSSASRSRGGRHRDDDAPGPSRKGQKRKAEEREDDGRSKKEREMARSRHTPWSADVDWAKCQNGAEALHRELMAFDHWMAPTAAEHETRCMVIELISRAIKSQFRDAEVHPFGSQETKLYLPQGDLDLVVVSRSMANLRTQSALRTMAACLRRHNLATDVQVIAKAKVPIIKFVTTYARLKVDISLNHTNGLTTASFVNSWLRKWPHIRPLIIVVKHLLMQRGMSEVFSGGLGSYSIIIMVISFLQLHPKVQRGEIEPGRSLGVLLLEFLELYGKNFGYDNCGISIRGRGGYFSKARRGWKDERRPFMLCIEDPHDPSNDISKGSFGIINVRSTLAGAFDILTAAICQQANEAGPSRSARTDSGRNKHRRFSVDSDSDSDAEARRALVRDSTAEGGKDDKDPNSLLGTILGISNPVVRQRKEMEELFYSGSLQFKLGRPAPPNSPPPARPREVRDSKADAPDPKAQSARQGKPGKDSKPGKDSGVVAISETASTGKRGAMPSLSIRGSANAAKASNSAPAPAKRKKEARAESSDDDEVQFVGARKAGDESEEDSRYSASRSAKKRTRKATAEITQEELEDLSQSAPSTFVSDNSDDERADAGIQLPTLETNSGTKASPKSVAGARGMTRISSRTKNDFWAAKGVDTSGEPSPSPPPAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJK0</accession>
    <name>W3VJK0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJK0"/>
    <dbReference type="HOGENOM" id="CLU_007626_0_0_1"/>
    <dbReference type="OrthoDB" id="2553934at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1111" mass="118927" checksum="74D6FE80115D981B" modified="2014-03-19" version="1">MPINMGQPSGSIDSSAHQVGHSANTLFPGGLPHTSMPNDPLTAALGLLPPELLQSHQHQHLHQQFAQLPSSQPVGSASLLSHVHSQMQTSHDSLLPQAPHVAHGSSASGLSQPPQVDMRQAPQLSNNQPGSSQQGQPHQQSRSRHQQRSPATAQHQQQQSQQPQPSQHQQSSRQSQPLPNHQGQQGQSLRPQGHVHLNHGQHQSSPQPQQPPNLAQLLGSASTAQTHQPALLQQHASVLADVRSSMSTFSASLHDAKQKTPADRADIRNVVSILDGAVKTLAAEIEQGVVKLRALQGSAALNSFAGLLSGSNANSIGPGSTNGNDLFGALNQFGLQQNQQQQQQHGNQGLPFDLGLGFHQQSQSNGMFNINGTPNSNGPNGGPSGLNAPFHNDVTIGQGGSGSQNASMMSSLLAQYLSQSNDPAGRLGALSLFQSLAGAGGAGSLPAGMQGLDALLNQALPQQTQAQQQTQQQARPGQQGAHLPNGAPLTNAAALAALTSLGVTPTMLEALGLGSVAQQMLEAPDDGPSTNSSKQRSRSPDMREDSPEAASVEGSSEPSRKKRKHVRGKVQIQPDVGVSRPPSKIVESKATSESRPGPASATPTSPPIASAANRDRNVASSSTIPGSAGPSDASKRIPTLGVGLRQEGDKRYRNRKLLRDLREHLYRWLGTDEFRKLRNTYKVAEWVPNPHLTDEEKQILASLPPAAVAQPPITTHIFHVDFTSRDFYRTNQSLIDAIVAEGSKKVEAKPEAYAIVPGTIDRDHLEDVAKDLMDSARSGFRMSLRTGLQAEKEDKEKHEKYRGVERAKTKCRNREIGAGRLRHAIPKQLLIPGAYSDDAASDEDLHGLTKSEWKRQRLRKLRIAKGWEAVTPKWRNKHLTRAYHKADIVSKSKQMARWRRDDPVDLPIPIKLYGKLLPKQLFDPDWLAEHRKELEEEPYCIRINDNDIDGWEESHHPLGEDTSDEMEWSDAKESSLRGRQLTSAPSSSRDRGSNTQSPAPIAGSSSVPITRPGEDSKAGSSTPVLQASSSALAASEAAQPEADKAPESKTLAQTASEAEATSSISGSSRSGNVDTADTGDTGASESESDVSTTDKPPAAPAQTDAMSMSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJK1</accession>
    <name>W3VJK1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJK1"/>
    <dbReference type="HOGENOM" id="CLU_006075_0_0_1"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000048">
        <property type="entry name" value="TBC domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="45"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="926"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1220" mass="129463" checksum="D5DCDA2B8C3DCC6F" modified="2014-03-19" version="1">MSSSQPRAGDPSLLHLLDPNDLLPGHTTADLYSLRHFTLRGGLPDSPSWLRAQAWKVLLGYLPPEKKEWPSVLAKRRREYYQFLSDLSPSSSSTQQPIPSHEITSNDRLLDQIYKDVVRSRKNGFAFYQASPTASASCPIVPAPPADEDQPGTSIGRVQRLAAKDNLLHRLAAVSPEYRQQLMLERTTSTTTTSSSSSNGSRPPPHVLHLNSSLSVSTALNLAANGAPDTSLEPIKSPPIVLSPPSPGGLSRESSRQSFTSADDALQSSTHGSHQDADNRHASKSAIFDAGNQPQDSVHGERNWHSLVRILYIFALLNPSIGYVQGMNEALFILLYVFGSAQYPSATSASIASSISQQSIAAADGDRPWDNDADLADTTSHAEADAFWCFSTLVGEMRELYDFERVEQQSRAGAALVADHQPSQTGMAGALLRFSLRIKWLDPPLWRDLRASSLDPRLPYYSLRWLACLLSTELSLPSVLRIWDALLAEQDSNSVSGSAKIEFLIDVCASMILHIKPLLPSSEGGQQLESEGFSAGMRVLQAYPDDDVAPVVEAATLVRQRRLAADLTGDGPPTELDDGEDSNATLAAVKARAAQAWREWKNPTPSSPATPVRTVPQADSGTPTTKGGWLVSRARARPSLSAEDADTSITSSADGDTSDLSTASKSSFSGFLAKYAEAMQSSDAAANLSKASTNLTAKALARFGDRSSRESTPEASVPHQRYGSLGRGLPLSPPPSESGAGDSRVATIGAIGASFFGRKRTHTVEGRSQSVNSPRTPDMTRWSRDTMPDFPLPNVSDSPAGRMDYVNAFGKRLSVAANGRSMASPASSVAGDDSGERRVSESAGSVALPSMRAAARMGILPARYREESASPRAAAGPKPLLLSQAARPPREGSSAGTLTVDEPSRKISSGPMGHSMSRENSHETRSNTSASFSRRSSRSTSVADSRRSSMVDFADAGMPGLAEPDTLPPLPSLTGQSAAATLPSRSGSFASDAGRPIVLQGGAKDGVVSAGAFARATKVEERPEFGQVASSSDVPLVTGASIGRPRGANRQRTSSSTVESAVSTSGSLGNRVSNRSSQTTNADASVAPVLNEELVDEPGGMEDGGADEWKPGHAVALTETTEEAVRKYTLTDEPTTKEPPSVGGLVRTKRYVKNRQMSTASTASTARRSALRLSNRSSLDPTANEEDAEAGVEAGVDSLALNGADPPRAPTPSTDRSTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJK8</accession>
    <name>W3VJK8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_04207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJK8"/>
    <dbReference type="HOGENOM" id="CLU_030990_0_0_1"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="544" mass="59002" checksum="BF98E2B3863C8B63" modified="2014-03-19" version="1">MVAASTTECGECSAAAKYTCPACGVRTCSLACTKAHKTDAAKHPCRSAAATHANGPSTSSCNKNDTSTPGGYVSMSEYGETHMMQDYLFLSSISRTTAEAGRRIVDMKLLPPSAAAAGGGNDPRAAAGPMQQRGMTNAQRQREQLLKQLHYRRLRVMVLPDGMARRKRNQSGFNPKSKRFELSVLLRLPLHLDAHAKGKAKSAPHDPAQDSNDERDSDGWMVHRQDAERNVADVVLAELERRSFTSRKEMLKAKDALGVAHKSWLVAAAVLETAGLVVAPARRCAWADQQWMALDVWPSEWVVHVPAYSARLTNESTTRYLDWWTRKRRWEEANPELAAEQKLQASRPRHDSPPSAPQPERSEPQVEEMPMGEGIVSDSLLSMLSQRLGRAPPETAPAAPGHAPEAEPKQEDEAAQAITARMYAPDTMSLTALLQQLPEGYAVVEFPELRIVPTAHPAPNAVDLTPRRQPGTRQHAQPRATPAVGAKPLGALLASYDSDSDDDDDGDTPALPGAKTHELESQDPEGGASLAALASVHGFVRPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJL6</accession>
    <name>W3VJL6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PaG_03947</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJL6"/>
    <dbReference type="HOGENOM" id="CLU_001493_0_1_1"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="17">
        <location>
            <begin position="123"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="18">
        <location>
            <begin position="796"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1049"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETS61843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121082" checksum="2B102B4E0A2D5C23" modified="2014-03-19" version="1">MSSSAPTGAAPEKPQQPASAPAADAAPADAPLGPDGQPMTKSALKKQAKLAEKLAKQAAKDALKSEKAPQNPAGSGAEKKKEKPKKEVKQEPEWVNNTVPGEKKDLSQPMENGYNPLHVEQSWYQWWEKSNHFKPAEPTDSDPHNPEKTFIVPAPPPNVTGSLHIGHALTISIQDTLIRWYRMNGYRTLFNPGYDHAGIATQSVVEKRLAKTEGKSRYDYGREKFLEKVFEWKDDYQSRISNQMRRLGASYDFSREAFTMDEPRSKAVTEAFCKLHEDGIIYRANRLVNWCCKLHTTLSNLEVDQKQLNGRTLMNVPGYPANERIEFGVIVSFSYQIEGSDEKIVVATTRPETMLGDTAVAVHPDDPRYKHLHGKNVVHPFVPGRKIPIVADAIIVDMEFGTGAVKITPAHDPNDYEVGKRHNLEFVNILNDDGTLNENCGDFAGMKRFSARRAVIDKLKEIGSYVETKDNPMTVPICSRSGDVIEPIMKPQWWVNCQPLAAKVIERVRAGEMSITPNVSEKEFFRWMENIQDWCISRQLWWGHRCPVYFVNIEGEAQDRSDDKFWVVGRSLEQAQERADKLAGGKSYTLEQDEDVLDTWFSSGLWPFSIMGWPEKTDDIKHFYPSSLLETGWDILFFWVARMCMLGVYLTGQLPFKEVFCHAMVRDAHGRKMSKSLGNVIDPIDVIEGIDLDGLHTKLKEGNLDDKEIAKAAQGQKKDFPKGIPQCGTDALRFALCAYTSAGRDINLDILRVEGYRKFCNKLWNATKFALLKLEPIASFQPAADEQPSGDESLVEKWILHKLNTASKTINECLKERNFMAATSAVYNFWLYELCDVYIEAIKPITDPAAADAKARASAQQTLYTCLDEGLKLLHPFMPFVTEELWQRLPRRAAEKAESIALTRYPVYMASRDDARAEAAFEEVFAAVRAVRGMCTDYNLLKDVQVFLETSDAEFQQILTSSSDVVATLVKGCTGVKVVSSAADVPKGCAVSSISSRLNAHLLIRGLVNIDQELAKLDKKLQLNAVGIDKISAPMNKPQEWSRMPQEVKDSTAEKLKNLEAEKQAMLAAKAQFESIRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJN6</accession>
    <name>W3VJN6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001477_0_0_1"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="498"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="833"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="1036"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="1208"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1300"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1306"/>
            <end position="1323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1463" mass="159051" checksum="9057F5F5EC0300FB" modified="2014-03-19" version="1">MRNLCVLSHRTIALSQASQPALRIEATASDLDDGSIYAVATSRTAPGAPDVTLSFLRTAVDGQGLERFSSLLVPGRLADLPDSAVGIASTSGRSKRDVINLHYLSDGGAEASHRPALCTIAAGGDLLLLPIPDASEAADDVPPAEPVVVGTIEQGIAAAAWSPDDELLVIVTCETSETASTSGAREVEKVLLMTRDFEVLSEVRLRTDEFGEDEAVDVGWGSKATQFHGSEGKAAAAAAAQAAAAAKASNTDTRGPRTPDDDGAPRISWRGDGAFFAISSLEPFYSPDAPTSWHRVIRIYSRTAALSATSDAGVRGISQALAFRPIGNLIASTQRFGASDLDGHMWAQGRKGRHDVVFFERNGLRHGEFSLREEAASQPDGVQLAWNEAQKLSAWTRTHAVRELAWNADGSALAVWLSRAGEGDEARDVVQVYTTGNYHWYLKQEFVATTRVEHVKWHPEDPLQLLVAHAGSVAHRVFAHETAVSPGRPPVDAACVAVADGSTTLLTPFRMQNVPPPMASLSLCVPPAGTEVKPSAASALAVPTHVAWSQLPGSSPQHAVGVMALLFQNGWVQVWRFDWGLLGGTVQVGGKPVAEPKLVATAQVAASDAHQIAVAGWAPTVLDATHQCKISVAVLSSHHQGAVAECIDLAQAKEAATFEATVHAGVPLRGHGKRRLVADPFVPTSAVPPSFYVQESDGTVQRVRGSALERVTKLERFCADVRVLVAADGKCKVIGLASDGRLLAESQVVARDATSFTLVGSFLVWTNTAHEARFLPLSSLRWSSANEVQAAASEAVDLGRRVERGSRIVTAVASAMSLVLQMPRGNLETIYPRPLVLEVVRRSIDAHRYGAAFRICRTHRLDVNILYDHNPAGFMANVATFVQQVADVDHLNLFLSGLRDQDVTKTLYKPLAASTGAADVAGKVNRICDAIRAELERLDARKYVQSILTTHVRKVPADYEAGLALLLRLKDEDAETAEEAVKYIIFLADADKLFDVALGMYDFTLTLMVAQHAKRKDPREFLPFLRELRALEPQEFQRFRIDDHLARHTKALGWLVRAGPQHHQQALEYIDKHKLYHEAIALLAGQGARLRDVYDRFGEYLLTRRKLDDAGAAFQLAGRGGKALDAYRECANWQEAMRLAFVEKLPASEIVAMAKGFVSELETLRRFTEAARVCLDYVRDVEQGVALLCRAGEFSEAHRILTTYSRLDLVEVTLHPGLLEAATTLVDDVQDMESQLSKQLDRIRDLRDKRSAHPDGALYDGDNDPALDNLDIMSDTSTQMTQFTRYTRAASIVSQSSMATFSTKSGSRKKEAKLRKKAERQKAGGKKGTVFEEDYLYTSVQKLIKERLGGVQAEAAKLLPHLVCAASGQVRARAGEVVQALDALEQNAHKAVETLWGYSQQDDDERFDQLVRFEQELLGGQVAANPTMAAVAFRSIANRRIPRPKLDVADTKWRPSLLDSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJU9</accession>
    <name>W3VJU9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJU9"/>
    <dbReference type="HOGENOM" id="CLU_411100_0_0_1"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="702" mass="76295" checksum="5AD99AB1890885E4" modified="2014-03-19" version="1">MARTKGITLRVRKQADPTDAAPAESEASTAAAAAPAPSARPDDPSQDGPAEEEMKTAESSSTPSLSRSRSSRLSRTRSHEEAFEASASTPTRATPARRSRRQPTKQEQHDEDVVMGSPQQEGGDLGDGDEADAHQPDAEAATTQRSRSSRARAKNSTTPVPQSPSASRSKRSPRKAPRISVVGRKGSARSRNAAAEDDDGAVPSEQPDEQTEQEGVADEYADGSNEAEGEDDDADPDADADGDVDADADADADGDDADADGNDDEEGVDEDGHKTVTIKGKTYRLEADGEEVILPSDPDGDKKIDDKGRLQGGRQYKAHHFTSDLRPDPEKVYMLSIDAARSAGYRDSLYFFRRNPQVFKIELLQAEKDKLIEDGRLSGQLKTRNVTMVPARNVYKLHGARFLSGGKTVIDDYYEAEARASGVKEGKTVGGMSTEEQEKRREAERERERPKKKADTFSYTTIDPQGEPVVTQFGDAGQTPWVRAGNWQSRKVALQRVDITEENWMLEMARSVRGMNTELGETRRDRMSAFPRLNRYVGLDGVAGPEEATDEVADGDAEPEDDPEAFNDLPPWERELIVASSGTDAEEENKKRKAIAQSDAETKRRRGPPIGVYEPNTHLPHFSVLTQPSRASMVKIAQRPAFINDPGRERGVRRPILGGDKLGSGAWGLASFVVESVPPADPPAYLAMPAAASEAAIHLAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJX6</accession>
    <name>W3VJX6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJX6"/>
    <dbReference type="HOGENOM" id="CLU_1555928_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="172" mass="19889" checksum="5E612C97CFE7EDA8" modified="2014-03-19" version="1">MLDAAIQRRISVAEALDDRFAAFPVWLTSQHRIHFGRPIYSAVFLAVPCLIFPHPLVTNLAGLSFTVLATRLYLELYLGLLPFEPQSPLQISEPQACPSPPFRTSDTEVEPPPEYDQVEPLPAYDQVEPGPPGFEELFYLDCDAEFWPFVWRGRRRNTNAQYRNIYYEQWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK44</accession>
    <name>W3VK44_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK44"/>
    <dbReference type="HOGENOM" id="CLU_886220_0_0_1"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="270" mass="30271" checksum="463A83374E3E2714" modified="2014-03-19" version="1">MGGASMSASLLGLKAELERTRASAAAPRRTSSSKPPKVAAKARSLHSPPRDDEVSHNQVRRSLERKARTYAQLSSGKYAGVSQAALLESSIDWTRKVHEHQSSSPPESADHDADPMVEYIDEFGRTRVSHLSEIPRHLLPREEKEEEEDGTVIYGPAQSFPVYTPAPRVAAKKFDARQEMRYRGAAFYRFSTDQLQRERQMNELAQQHSHTQAIRSTTQRKGGTSLLKTRLAQRAHKVHDERLRILGPAAVHQRSQRIQQARLAALLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK99</accession>
    <name>W3VK99_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK99"/>
    <dbReference type="HOGENOM" id="CLU_042324_5_0_1"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="323" mass="36514" checksum="04636A62ABC2BC24" modified="2014-03-19" version="1">MLFVDKYRPKALSELHYHHDLSKRLSSLAGHEDFPHVLMYGPSGAGKKTRIACLLRELYGSGTYKLKIDQRVFVTPSNRKIDVNIVSSNYHIELTPSDAGIYDRLVIQDILKEIAQTQNVDLNAKHRFKVVVINEADSLSRDAQSALRRTMEKYMANLRLMRTVLTHVAKKERFTIPDAVQTQICDDCNGNLRKAMLVLEALRMQSPGLSAGIGIAKPDWEIYITKTADLILSDPSPQNLLAVRSKLYELLVHAIPPTLILKHLTDNLVQKVDSQVRPAIVQKAAFYELRTRTGSKVIFHLEAFVAAVMHIQKSFLLGMSWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKB3</accession>
    <name>W3VKB3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKB3"/>
    <dbReference type="HOGENOM" id="CLU_046582_4_0_1"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="14"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="326" mass="36531" checksum="85D48C88B47859E9" modified="2014-03-19" version="1">MPTAIRSTSNTTPVFFFSHGSTMMLGEQSTPAQYWEEMGREAMRRGIKRVIMMGAHWESPTDEILVAANPTNPKKQPVAWVEPSRYVDYKINSSPRLANEVVARLQQNGIKAKTDPELEWIHDTFIILCWMFPATTEHPQGQCPEVTVVSGLSVYNAPLLVDVGKALRDFRNEDTLIIGTGGTVHNLYRNNWKQITIFRDNFAQPLPPAKWALDFRTEVEDAVVNNSGPALINAVLRLMRHPLYRDAHATDDHYAPLLFVAGAAGSLKDKGKKNKITAECWELQNMCNSRKFLSPCLCVLSDVGSADARFCLTVLDASSEFQFGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKC9</accession>
    <name>W3VKC9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Decapping enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKC9"/>
    <dbReference type="HOGENOM" id="CLU_710044_0_0_1"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09804">
        <property type="entry name" value="Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39332" checksum="7CF42F4B945124C5" modified="2014-03-19" version="1">MASIPEARTSFNLKVLRRHDASIVEIVETASFVVLYNYNGGEWTKTGVEGPLFLFRRRLPPYNGFFLMNRNGVENFSADVTQEDDLEITPEFIIYRPETNGDNEVYGIWVFEPGQRMAVGDKLLKLQQMTEPPSQAQIEAAVAASSSTVALETSTKEKTDKKEKKDAQQAAQADKKKAKKKNAKDKDKNSERKEVEVEAEPEPEAEPEPEPEQTTQISLDDLFGGAPAAAAPQEAKQVEEGQGQQKTSAERSSLLDSMFASAVSLDAAPAAAALSNAKEAPKPTPASTAAGPATAPQSNGASTQDKTSMSALIEQIILQRIALGDDGKPLSRREFVTELLSIIHTDPAFVTALYDTYLARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKJ5</accession>
    <name>W3VKJ5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKJ5"/>
    <dbReference type="HOGENOM" id="CLU_332931_0_0_1"/>
    <dbReference type="OrthoDB" id="2337158at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="890" mass="97002" checksum="54011C3276923539" modified="2014-03-19" version="1">MPTPACLTATTTTQPLATTDPLPSPLPSSRLASAMTEKLDSPAVNSGRPYVVLPPTLAQLVEDRFDEDQYEQAVALLEQVLTQGLRPSAKTIQRLMALSLCSLAPGQLASTSRWTLDDHLHDIASGLYAHTKRNNGEKRDLKNAASSTSEGPPPEAVVKATSLLHEYASAAAAQPSSGQGSSSQLREDRTLPLTAHQILESLPSRRKPLSSSRSGSPRPSRQTRRGSVPSDGSGRDESFEQSSVERWISEHLLQAEDIWDLLCGRQFSAATTSKSASLTYVYEFWMNASQRKRFLRQLQSADPKTHRLEDKLRELQRKKKTGEKMESLSSDSDQDSDSDDDLPSLSIPGRGKKGPASPKGRRGLSTASPSPKKRPRTDKPSTSQRDDDETGQNQLQMTEGAWRTLAALVALWERTTPLALPTDDGQDSASKNSKPPLLWQFPRSHLARKGPRGPNPHDATDDIDRALDLAFSFPRILPAFTPPSAESGNDYGLFDKAASNQSHGHKRLLSSVPQAELMQRQTIGEQRQQQWMAARAETAARLLSLMYQLVKQGYIQSGVFTEGVSDRLEALDAVEIQYIILPLLRRQPSAVASVLASHLEDFAKDPAGSKKRTASSTIPIRIGDGVSLDLDLALAQVLPEEEAAASRLRRCLTRDQSGDAKALQAFLSLNRLELDASANTSSPLSFPDKAAGGESEVVRKQASKTARVVTISRVKGRPTTATAKDTSGGTNDALTNDMKKGGIVAFAFVRILQMQDRDRINQIKFLLARSLASAQTSSRASSGSDKAEESGSTSREAAVAVQPRDVRSFLSRLIKAFERDADEMEQCLSAMDTHVDSQADSRRTKSETQDIGAMQLPTLQSLINRGFKCLEATQTLAHSTRVLRECLASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKV6</accession>
    <name>W3VKV6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKV6"/>
    <dbReference type="HOGENOM" id="CLU_075696_1_0_1"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23959" checksum="726C509365ED5A24" modified="2014-03-19" version="1">MAVKHNNILHNNHFRKDWQRRVKVWFDQPGAKKRRRTAREAKAAKLGLRPVQPLRPAVRCPTIRYNTKVRSGRGFTIEEVKAAGLGKKYARSVGIPVDHRRRNKSEESLKLNVERIKAYQSRLVVIPKLTKKNKDKKVDLSNVEAVRSVQVALPLPKGVEAEKPRAITAEEKEFNAYETLRKARGTHRHAGKVKARIQKKEEEAANAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKW5</accession>
    <name>W3VKW5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004319_0_0_1"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02666">
        <property type="entry name" value="Peptidase_C19J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="704"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="835"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="872"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="932"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1226"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="945"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1387" mass="151859" checksum="1D2698EF8D9F39EC" modified="2014-03-19" version="1">MAGGDQHGDFEPINILDNVTANAAADDSAPVDITINEEDHKKVFGQDSSVPFGTKLEPLPPTITGWDVPISPPPEYDYSEAAVDPAALPDRSKSTPVGTFHLLLPTALHESGLLFNPQLSLSKITAHRESEPSEPSQPSQPSQPTQPAEAAAASAASSADSVPAPCLPEIQACLPHPNALFVAETLEWRVILDQSDVYRTPLPDFAVYDASHLFDVCNLPPNSVSVFETAPTSIPPQEQLHPIRLLDQWDAEHPEAPLPVIEEFNMHKCWITGRRLLSTPPDTIVSVIDRHVLSRFKESRENDPAVGLTGPETFVRALRVLLRIIGNFVHGERRPAPTSSIMVTQKLGWDQHSCQIFLDLGWKEDRLPDGRNAIRPPLVAPKSAPVDAPSTMSSDDIILQRHIRAWLELHAWLAFHLQALQISKPASSLLQNTEPTLATQLKVESASESVIEMIREQRDHLDTSLNRNLSNDTLAALFALGVSSATRDELVKFGYLVNLEANPKRAADLFASLDEVYEAQRRTSRIIQELVAYERSQGKYSPRDLDKAYERLNLTSTHLGPDVDRDSIPHDFVADQYKARAREVLVNADVAEHAAVKDALKIITAHRGMPPTLVQALEEDVDMDVDQAYTTLDANRDLDDATLLAIYDLYIADAPARRDLLRHALRAIAEDRNSNYLRHFLKTGEKDAAANEGWQQMPSADVPAGIDNIGNTCYLNSVLQYFFSITEIRSRVLRVAPSVEAEQDSLSAAVSERRVGGQRITARELERSRRFVAQLAQLFHHLIYANALSVRPERELAYLALVSSRAEELEAEVHPFTEAPSSITAETIEPAPADVAEPGAMSAPTDDAGESMDTTGDGPEAAVAAAIDPLEPAASSAPPLPPRPARKPSAAPVPPPARRNSLMQLGAQQDVSECLDNCMFQLEVALAVGQDGASDASNGMDVDDGQGASGSTGAASSGDSTREDLLSRLFLGKTCQRIEADGVAAGGSEDRGGRPQQVKQPSMHIKHEVFKIVPIDVLEEGRDIYDGFDGFFDSDTFVATSGAVQRRSVTLLSAPPLLQIQLQRVQYDRATMRAFKSQEHLDMPEVLYMDRYMDLDANDPENAPRMAMREKYQAKRRRIEELRAHLAACKDGAFTLTQTLSQAANTVEELARLPSLADIEAQLAEIQAEAARRGDAEVPPAVSPRSRAKQIADNGVDTMATTPDTSDIINTAVQTGVSGLVDAGLETLLRDEAQVLREQMEQAKSEIAALKSEMGAIWAGEERYTYRLVAVFMHRGEASHGHYFLNLRGGKEDKWFKYNDSAVTSTSLGSVLRDSSGATPYLVTYVREDYVQLVDPICRVIEQDTAQEVDGAKGWDVELPKLPEVVTEVARDAGVESPVKRARTDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLM4</accession>
    <name>W3VLM4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256584_0_0_1"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF147">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE OF THE SEVEN BETA-STRAND FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="1183"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="1288"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="836"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="961"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="961"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1270"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1367" mass="147631" checksum="2E69369B3331A300" modified="2014-03-19" version="1">MSASTEFLPSRDLRQLRALDLASPKCLDVVTANLDSLAIVLGASGGQILHAPPHPTANDTQAHDDFQSSVEDPPQETDVFEQRYITRWLTRLVSEFAMTSAESQEMQDRCELLSQRCAELLALAAGKMAAGASIQDHIFQLSDGEVIVKLRDGALVHDSLGTHTWGAAPILSQLLLPVDADSKRDLNVLELGAGTGLVGLTIAQWSRQHRRDAGTRVVCTDHHPTVLENLAHNIQLNHWPASVAQASQARVDVVARCLDWQSVYQSRSGQASSAHQLLTSQTVPSHLVASAQSDWARQLDIGSCQHSFDLIVAADCIYDPVHPLWIRSVAESLLKPADPSSGVQPLLHIMVPLRPTHQAEMQAVYEAFAADRPGERGLRLAILAQRDYQGYENFGAWNSVVRAAGPVQQSQPEGGLARTYRWFVIVSLEVTGRRVRAERPQGFADFFSVSHWGALAGWADVPTAQRALGWLSVELVGAVLCCALSRIIAALRLDWVGIFISPRWCAQFKASRAAPPPFAPTTTAPLHSAPLLVINQRYVASVSATAVLSPPSRWRASHLLCPPAPPAPATQPSQLPLGSPPPLAASGSGRAALVAVRLPSRHRPAAAHRLLAASPSSVLLLRLWAASQVTIPALPACCTNPPGGCRPGRHFENFILQVFGRPLCLIAPASHFGPRRAPRRWTKHLFGAARTLPQYYITFFRLAPPPSPLLQSHAAASATHRALHPQLFCEVRRPLPRTIHPSASPHALDRHAPTSSRVASIHSSSTSASTSGFLVTDPFPAFIFPRLTQSLTRHHLAVSTPLRLTGRPHRRHQIRFFARAVVVRLPFRRACELKWSSRRHATSPSPRRADPSMASQHLVSPQEAAAQAQARRMQSSDTHHNPHHHPHPHAGSDDAQGSQYFNPAAMHSRNLGMDNGNAPSHYGGMQLPPLGAGQSNGGHGNMGHHAYGSHFGGQGHAMPSQLSYPQHSPNPSHAHISGGQNAGPMSMYGYGVHHSSPQQHYSHVPGQAAHGGMGGMVGGAGSNPMMGAPGGGSSGNDFNHGFGQQSHYHQYFQPQNLQSISPSQAGAPPAASNAASAPAPNAAGSAAAKGSAKAAKGAKAPKAPKAPKADKKGAAAAAPPAKAAPEPKGKASKKGASADAPKAKSKAHPYAQPEPAADTKPAKKQKKEDPPKPSALKSRLKPPKQAPSAWQIFFTEELQKIKAQSPDERLNVAHVAKDAGQRYAALPESKKQEFHRRSLEAKELWEQEMADWKAKLTPEDIRQENLYRSAQRKAGKSRKGNLKDPNAPKKPLSAYFLFLRAIRADPNMTQAVFEGEQETTKQSVLAAAKWRSLSETEKQPYLDRAEADKARYERLRREYESSNGLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLN4</accession>
    <name>W3VLN4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_04152</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLN4"/>
    <dbReference type="HOGENOM" id="CLU_020931_1_0_1"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="718"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS61656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="764" mass="83371" checksum="46D8AA971B43469D" modified="2014-03-19" version="1">MSHPTMAGSDVVSTDLASRAVKDSTVVRFSSVTPASESFFSLRTPAALAPRSGAPKGFSALAGTRTCQLRCQRRAPSGLDASPRPGIATQRLHWLGCIEAESAFVSQGGGMDADVHSPKRHGSRSPIGTSVTFGLRATHNPPVQVPPQPAEHSEPLAASTSSLDNMNGIASSPTVVGKDEIYDLLGIGYGPAHLALSIALRESAEAGEANFKAHFLEQRAHFAWHPALLLPGSQLQVSPLKDLVTLRDPTSTYSFYNYLHSHGRLARYINKEQGVPSRREWTAYLAWAARRMADAVSYGQNVISIEPLTIVAAEAKQHEVTVRQADAEDTLCLYRVTTREADGGKVVRYARNLSVAVGGVPKLPAAFEAAYAQQAEGVARIVHSGTYLPSMRMLEPKLHEIASKRQQSAGDAVDDSSRLRLAVIGAGQSATEMLMNLHARFPTAIVTMVFRASALVPSDDTGFVNSAAFDPERTDEFWHASASQRRAWLTEFKRTNYSVVRTDLLNELHDTMYDKFSVQLPDELQDVDEKHAGRMEMRRCTEVDHVRLTEDGVELELRDKLRNGRVERVVFDAVFVGTGFVRSPSRMAFLEPLRAFYPALDGEWMGRETGSEEDEVARLVDVEDEEVLERRRENIRGITRDYRLVGAAAMRSALRSGKASPASDASSTSSQQTLASQAEERNLPEPALYVLGGNEATHGLSDSLLSIVAHRAGELSTSLLDRLPRSRAATAPSTTSPPPTQTQTQTHKIQKPLTLPALQHMSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLT2</accession>
    <name>W3VLT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLT2"/>
    <dbReference type="HOGENOM" id="CLU_012388_0_0_1"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF27">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="987" mass="111231" checksum="223A6C75DA921035" modified="2014-03-19" version="1">MTAVLPDEVVYHIFSFLDSRSLGNALQCSTTFYRIATAPALWEIPYAIRWSTGDAEREEKRQTARWRQTRRIEQLEAHARRARLEKAQPSHPPTDPPFRYLRLNSKHAHLEESPQTGSAAGDPDFYRLFIERIAIDQQVLDTLYQQVEATHARIPAVTSLARRFGNDAKDVLTAVVEAQASYPSGSTHGLPASPTRTASTDFRINAYQAHLPTTLRSDTHHLVILHHAREILEHLQRRQAMHKIDLLARMAHDTPEPRLEPSISAGRFVPSDTEAAVSLLTMFRGGDAAYVEAQLDELAAACDLYLQERLPDPSTLATSGPDAVAAAKDMALAICDFLADHGFRGARDNLFTDLDNHFLHHCFTTNRETLPLSLTLIFCGVATRLGLRASLCNFPMRILAFVMVDTSAPLPRPDETLASVQHDMFWLDVTEHTTVAYNAHGPTPTDAFARQQSWLDQRPAVLDRDDLTNWIGRIGVPPSDDFWRPASPDVMVQRAARNILNSVQMAQIRPRNLQPGNQTRNVIRSIELEQRSARLQQQWTHLARVDLAFLSSIYGRSDAHEHDRITKTVVEALEGRIGGAHVPEDETTWSIVRRWRGESMRSLTTSPECWSLPAVPAAQRFRDWMDERAVDNDWTRVQDDLYRRADHWSEHEQQAAKYAAINALLRLNTQVSAREVDWIAAFLQSYFMLDVDVIERDFLGIEHGSNPDPAHDAGEEDDSEGSESSHEASWSRREEQDGGGGIVQNASVRVILRRMLQAVRVKDAQPPRVNRRAGAEARRKRLRRAPSLATGQADALSDVAEGGDEEDLIGYRVGTVFRHHTYRYAGCILGWDPHCAAPEDWIVNMGVDRLPPPRAASPTASPRQRRGGRHQPFYHSQVADGTRRYVAEVNIERVSGPIWIYGLPNNAAAGIEPEEEARSLGAAVHQMLALRGLGEYFRCFDQQRSILRRNLDCTTMFPDDWSDDDAEQQHPRDDTVETDRLSEDGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLX3</accession>
    <name>W3VLX3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03152</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLX3"/>
    <dbReference type="HOGENOM" id="CLU_024666_2_0_1"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="446"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="66182" checksum="B42A30ED528A9024" modified="2014-03-19" version="1">MSTWAAMAAAANKAPAPAQPDTSESSEAAAASTSTAAEHAATDASEPAVRTKKPRIETLILDAGALIMRAPLDGLASEYYIPPRVIQEIKHASAREYLESLRLRPDFKLNIVQPGPASMVAVTEFAKKTGDIGVLSTQDLEVIALTYEQEVHRHGTKRIRSRPDGPRGEATSTSSSASATANGAEDNAAASTSASTSADTKAARQAAIEKKRQQKADAKQKKLEEEAAAQGLTVDQLVAQRIQQSREKKAAKKHAKAVAAEEAAAPLDDAAGSAEQDAVQEASTSHVQPGPEQGWHDADYTDDDEEEGEGEGEWITPDNVQKAKNFSLGFVDDSRMPGWKYSVDEAKDDVPEPADLIQPEEPLDEGWERVESSSKAKSKSAFKSGHVSRDYNDPSIQSRPSLSWDAMGNVSNTGHMTVACITGDFAVQNVLLQMGLSLVGVHGSRVRSVKSFVLRCHACMKVCKDMEKKFCPVCGNATLTKVAVTVDDTAKGGFQLHLKKNYRFNLRGTKYSIPAPKAGSASGGKTGGSGIILREDQLEWQRALAKEASRKRKEERALEKAMRAGKDSLSVRYEEAWDTGDIFLGSQFASRDKSSLPVIGHGRKNPNANRRTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLZ9</accession>
    <name>W3VLZ9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLZ9"/>
    <dbReference type="HOGENOM" id="CLU_340693_0_0_1"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="195"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="573"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="744" mass="80499" checksum="F71CE091309FC71A" modified="2014-03-19" version="1">MAEVARRIPSQPDGGSSSRSYSQSPQKKSHHRSESQSSPSKKAAANGVDKRTSASLPSSPSKEERKKLAKQILATGGDQLRATLKQRGMLHALLADPVKFIKSAQKQGQDYTTLGLTPVNDANFAAAQKRKQEQKQHALLLHTDSPKINGASAHDAEATASAPSSPTKAAKARSRDLYPYKISLRFPGKVRTAAAGLSNYGNTCYMNSVMQALVHTPPLAFALLTQELDVLHGEWGGKPNAAFDAVTAMHSFAKRSLQGTRPTNAPQEFNRNLKAFAKPLRQGRQEDAHEYLRFLLEALQQSCLARAPKSLKPDDPARRTTFVHKTFGGKLRSRVTCHSCGHNSDTFDPFMDLSLDVRKGINSLTDALRAFVAKDHLTGAEKYKCDKCKRKVDATKQFTIDAAPPALTVHLKRFTVFGGKVSRQIAFDDTLNIAPYLSVNNGPARYRLYATVHHYGSGPNSGHYVASVRSPSGKWMRMDDSHVAEMGRSGPTNDQSAYILFYLREKDEALETALAAVAPSKSAPTSLEAKKRKKAAVQETVSESESDASADEFDDQAAHRDLLKRRKAKKAAALQARAESDDSNDDAADKPALGGPSAKLDELLSARPKSAASFYGSSSGRPANPFSMPSADDEELGTSVDRDEYEAIVGDSPRKPTTRTIDPEADDSDDDATVAAAALSKKEKRRQKKAAQAIGVAKAGRGVPASPYASAFTGAKEQKKLLKKKDRMKGAGGFAGRMKPRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM15</accession>
    <name>W3VM15_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxidase</fullName>
            <ecNumber evidence="13">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PaG_03195</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM15"/>
    <dbReference type="HOGENOM" id="CLU_036959_1_1_1"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="15">
        <location>
            <begin position="196"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETS62560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="399" mass="43216" checksum="85A96E53904873E9" modified="2014-03-19" version="1">MASLRTGLRVAQPLRASARNINTFARPSVRSSVRHYSSPAPGSPPPPQPSSSSSTSKVLLTSVAIAAVAGGAFLAFGQDDKKSLLGVGPDGANKLSGSKGAAVAATSAHSKADYQAVYNAIAEQLESNPDYDDGSFGPVLVRLAWHASGTYDKHSNTGGSNGATMRFAPESDHGANAGLGVARDFMQKIHDKFPWITYSDLWTLGGVAAIQELGGPKIPWRPGRKDSAADKCTPDGRLPDGDKGPDHLRHIFYKMGFNDQEIVALSGAHALGRCHTDRSGFEGPWTFAPTSFTNEYFNLLMKEKWNMRKWNGPPQFEDKSTKSLMMLMTDMALVQDKSFKQHVQRYAKSEDEFFNDFSSAFAKLLELGVPAENFKAFETKLDGGKPFEFATSAEQENAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM25</accession>
    <name>W3VM25_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_03207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM25"/>
    <dbReference type="HOGENOM" id="CLU_1027434_0_0_1"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="4">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="243" mass="25802" checksum="53639DED6CEF49BC" modified="2014-03-19" version="1">MASTSTLSSDRVGSGESSSLPDPTSHQLSKRQQYDALLDAEAGAEANVSLGSPASHPSYPAVASLCRTYPTQASAIFQTYLDLKNGAAAWDVVEPLSLRHPQQARESNTAVLGSAELEGLSESEARELVQNTLANWRSSDTRLGLVNPPEQGQGQDGDLMLALGLAAIKGRRKNATAYEIVIPLTISQHLTTSQLVGIFTLLTQHAASSTDTVDTSHVLLAIIAPDSTLVYYTVSQDMVKPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMK3</accession>
    <name>W3VMK3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMK3"/>
    <dbReference type="HOGENOM" id="CLU_1171056_0_0_1"/>
    <dbReference type="OrthoDB" id="10413269at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="237" mass="26115" checksum="4B01C81097A28D82" modified="2014-03-19" version="1">MLDSRQEVKQDVRLHASFMHSAVADAGRGKGHRDSSHRPFGPSSATFSYTSRWAGPVAVCLRSCFSPASLEVSAQLVDAIPPARVDTRSKHVPVMADRDRDTSTLLGADIESHHLVDASERAELERKAFDIDGFVGIEHDFVSSDDEGTITRVFYRFGPHHTKPFDINLANLAGDLPGFLRMLRWPAEGETESDAQRHLDMLQRSGDYAATARTPPTTPNTRTEDSAAVNKVEDDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VML0</accession>
    <name>W3VML0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VML0"/>
    <dbReference type="HOGENOM" id="CLU_010811_3_0_1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="256"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="678" mass="74783" checksum="3408A533CD4F2EC7" modified="2014-03-19" version="1">MASEGAKVGAATFELMWRHALGAYICHRLTVEHDCNSGQIRRLAMAAQAGYYAGGRNDEDSHQPTLHVATMAPAGGPVHRGSFSDTDSSNGSAHPLHHTTEHAAGHLPFPSGPHGDTYSDASSSAYSRPPASSQTHTSQDKFRAVAWLYDYDGSAEADDWLHVPGVERKKKISERLCGCCNISFLGFLNLATLALISCSLMMLFAGYPILQFFRKADADRKAKTFFGLGGTNGTGQVPLLPGLFSLIDQDTPEKAYSWKHPIDGGGFHLVFSDEFNQDGRTFWPGDDPFWEAVDLHYWVTGDFEWYSPEAVNTSSGFLNVWMQEHETHNLNFRSGMLQSWNKFCFQGGYLETSAVLPGSHDTEGFWPAVWTLGNLGRAGYAGTTQGMWPYSYNHCDVGTLANQTNPEKTAPHSALHTYTPYDQNGPGKKISYLEGQRTSACTCPGEDHPGPSHDIGRSSPEIDVFEAQTYMGHGSASQSFQIAPFDANYSWSQAPEVAHLYSPDATFNTYTGGIYQEAVSAIARVPDTAYDQSGGIPVRFGMQWDPDWDGDGSGSITWFVDGKPTWSVTGHALGPNPYTEIGQRLIPTEPVSIIINLAMSDGFQAVKWNQVQFPAVMKIDYVRVYQRDGQPDRISCDPPDHPTAKYIQDHLDVYMNNNYTVFPQDKYGWPKSKYLGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMM2</accession>
    <name>W3VMM2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMM2"/>
    <dbReference type="HOGENOM" id="CLU_042860_3_2_1"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="17"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="114" mass="12718" checksum="FDA31A32B0093555" modified="2014-03-19" version="1">MMEPSTKPTHPPKDDPISVEDLKQYDGTDESKPVYVAVKGTVFDVSPKREMYAPGKGYNVFAGKDGSRGLGMSSLKPEDAVPDYSTLDDKQLKVLDDWHSYYTKRYNIVGKVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMT9</accession>
    <name>W3VMT9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMT9"/>
    <dbReference type="HOGENOM" id="CLU_004953_0_0_1"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="727"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="873"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="881"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="927"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1022" mass="110045" checksum="D27453CB60D02C30" modified="2014-03-19" version="1">MDLLSRLSGLVTTPAKAAAGISGSPRLRHKPSLHPVGSVDVFHADWHAVQAELEAPDERALFFGIARSDLPRRLQRLVDALVFESNRSNDGHTGPCMEYLLKYDVLTQLVHLSVDDRPKGIRGETIRTLTNLIILLDERFLSRHAVNKPISQLIQLCLDEDAARFQMDDDSFETNRPTPSSSDAAAAVPEADYEEDLVDLMCHIASRIRNTPDLLHIFFADEPVDDADESIEVRSLKDGSVIVSQSMLDDPSSSGHPSPDLASAASQDWQGRPSSPTGSIDSTATIQPSTAHTTRKHAKRRLRFPLFSYLLKFVHREGRIGELARAGLLFLISLEGVNAPSKSSLQSVKGRPATKRVSFGGDDIRRSLAAFIAHSDFADVLGAGLGAAYGLLPSRMKPAPRYDPASIEPSSSQPGRASITLASSSASDADEAGASEALASATQSDDKELQMQLRLVVDLIEFCQDVLDSLWLTSRNLTEPTSADEVGEKDAVREETGVRELDPMIRKLARAIALAIRDTFIRNVVYPSLMESSDFDGSSAAVLNYLDVMVIVLRSGHILTDVALDFLLPADGAPAEAAYEINLPADHADRYSVKDLILDCLDERKRPATRVAALKLARTLVVCHGVRACSGLLQAPRHPASAAVDEWAVEAGEASEALGVGRIEMHFGEMDALAALLAPFGRGESSDWLHASLGNYLLDAERALRLDSTFALALELGADKLRLQATDSLVQQLFGSLAQLFAQPVEVNLATTGVVVALACSPLRSLEGWLIHASDAGNETPALVELLGGLVHQVESYRTAVAGFDAYLAARRRSLVLTDDLSEALQHDASEDDSPAEGKSRVSACLTLPRVVQSGGKLQTDTAARTAEREFGIVDDRRDSLPALSPAPAANKSAGQAPVAEEAAARSAIARLFGGRPTRTPTTAAKAEPERPTAGERRISSSTINPYAEHFRQTAVVVVKTQPAVGAPMWRPPPTAGDATRSGKATLSSVLDNTIVLEEFIKELMAIVQVRRSWGIDLVAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMW4</accession>
    <name>W3VMW4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_02674</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMW4"/>
    <dbReference type="HOGENOM" id="CLU_004585_4_3_1"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001201">
        <property type="entry name" value="ATP-dependent DNA helicase UvrD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="15">
        <location>
            <begin position="37"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="16">
        <location>
            <begin position="340"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="600"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="994"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1019"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1072"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1099"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1146"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS62909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1167" mass="127348" checksum="B0FACC372289A397" modified="2014-03-19" version="1">MPPKSAATASQPSGSEPGSSKQGDADHPTDVPSYLRSLSKSQLAAATHPPTACLQILAGPGSGKTRVLTSRVAWLILDPSNRLTPEDILVVTFTNKAANEMKLRLVKLIGKERVDNLVIGTFHSVCARYLRKYGRLISLPNNFTIIDSDDAKRMLKAIIKELKPELDKEHISLKPEEAMSEISKAKAREIDPVRYRQLADEEAARAQAKKAAIGRQFTGSAPFKAIISTIYQMYQEQLVEANALDFDDLLVYGVQLFRRQNQVVRNIRHVLVDEFQDTNVTQYELMRLVAYSSQAVSIVGDPDQSIYGWRSAEIGNLDKMTREFKGTQQARLEENYRSTGAILELALRVVQQDTSRVQKDLYTSHPRGPPVVLKCHGSAQLEAAYIASEIKRLVAHSGGMLDYNDIAILLRFNYLSRSIEAELQARGIDSRMMGGHKFFDRMEVKDLLAYLALADNPGFTPAFIRVVNVPKRGIGEKSVTDLLNMAKAEGCKPMELAERVVRGGKNPGIKPAVKKGLKELVDATVVVREAASSGEPVSKLIELLIDKINYENYLKAQQDYESRWGNVQELISFSAVVAQNTDPDANAPRVPLEEMLSHTLSNQEERVDDNSEQDDDFEEVEIKPTKKSNVRSTHPMFDKKGGAETSTRPRAPVKREVIDLCDSEEEETESKPQANHPEEDLKPGPAKRPRTQKKEVEKDLIEEDQEDEKPSLLTMLDEVVEKKGTQEGSQAGDASDDERKTPLRVFLEASILATDMDADNEQKDEKARPKVTLSTCHAAKGLEWPVVFIPAIEEGCFPSFRCHKPEEIAEERRLLYVAMTRAEGVLYLSHATARMQGGETQDKILSNFVAAVAPKRNGGSCEAKKAIQFCTDRPELDLDAVRTVAKVTGKPAPSEELVEKAVKEWKKTSGKELEQVDQMNIGRMTGFGTYSSYGGAGGYTSSGVHRGATGGWNSQMGFGLYSDDRLSTHGEGSSSDQELRRKLGFSAPTIGGFSSAIDEGASPPPAFSGFQRASSLAGGRSGATSSGGGLGAFSGRPPPGGFGNGRQKQPLVPPSRQAQAQPPAPPSFTDAVRLKARPEDSVALAREDGTAPRPRADLNSFQQAHSQGISSMLSMLPADSNAGGGSRASPIEVSDPNGNGDGGSSSTGNGSNGNARGRRRLGMSRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMZ8</accession>
    <name>W3VMZ8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-coenzyme A transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_02802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMZ8"/>
    <dbReference type="HOGENOM" id="CLU_020502_1_1_1"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="64347" checksum="1F287B5B2B0F0F88" modified="2014-03-19" version="1">MGAAKGTKESLANGAGDDAKLRQRPTAAMANGTPSSEAVETSDLLATRHASIAEADIKANDPKQQGGEEASGFMDLSPRDQRAMILLVVLYLLQGVPVGLAFGTMPFLLKTKLSYGDIGFFMLCTYPYSLKLFWSPIVDSTFVNELQLPLIGKLSLGRRKSWIVPIQTIVGVMFWYLSRNVDQLLLADLPNVKLITLIFFVLILFAATQDIAVDGWALTLLSQENLSYASTAQTVGLNSGYFLSFTVFLAFNSVEFSNKYFRSTPLDYPLLSLSAYMRFWAFGFIVVTAWLLFFQKEDEEADDAPDMDVKKVYSIMWRICQLKHVQTFILIHFVAKIGFQANEAVTGLKLVEKGFGKEDLALAVLIDFPFQLIFGYLAARWSKGDKALQPWVVAFFFRLGFAVLSMAIVHGMPSAPIGAGYFFVVIASTVAGSFASTVQFVGISAFHTQIADPLIGGTYMTLLNTVSNLGGTWPRYFVLKAVDLFTISSCQPPSSALLLKDAEIAKLWATASKGIGGKECTSDLGKAACSAAGGECYIERDGYYWTSTLCVVVGTALLVTFIIPACRKLQALPPSAWRVNLQSHPKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN15</accession>
    <name>W3VN15_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate--cysteine ligase modifier subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN15"/>
    <dbReference type="HOGENOM" id="CLU_568723_0_0_1"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="41805" checksum="3CF6F6282A69E02A" modified="2014-03-19" version="1">MSSSTTAAPAQEEPFHALYIHTHDVSRSLKPSADGELAHAIHQTLHFALDGHPDDYTPAAANSGAGSGCDPLATMPTSSAPNGSSSALAVNKGFAATGDAERPYISYYWDAHSGTLALPNPATITNPVADPCSPDHRSSYEITAKFFFLDEVDAGLVDEALTRLTRTTGIITIDTLVLSFPTLDLDSKTSTSTEAIGQVAQVWQHVSQNPQLFSLGLADISPSSLEALLGSLDPPVQPPSMPLFSPAIPLSSTTDAASTSTAEPELASADVASRDVSTEGTFWNIEYSLVSTARRPRLVSINVKQDPCAFDRHFSQYCASMGIQLVAHSDRRDVLPQRTLPALMDEFEHKMPKKAPKRLRPKWALKYTTLIRDRGVLADKGYIVFVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNN0</accession>
    <name>W3VNN0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNN0"/>
    <dbReference type="HOGENOM" id="CLU_042860_1_1_1"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="93"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS63233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="206" mass="22829" checksum="7C069E557B6E1866" modified="2014-03-19" version="1">MDQLKQRLFGPPETSSALDTLQSLAESIYTNPLNITLFLAVLYVVVPLIRPSSPNSSRWTPTVAEARSHQSAPSDRYTYLPPNHPDTVEWTKYTPRTLAVYDGTGTSASEQDGSRILLAINRKVFDVTKGKNFYGPGGPYGNFAGRDASRGMAKQSFDLEMLTPLDKPIDKLQDLTPSEIKNMKEWESHFTGKYGVVGELIDEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNP5</accession>
    <name>W3VNP5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNP5"/>
    <dbReference type="HOGENOM" id="CLU_432190_0_0_1"/>
    <dbReference type="OrthoDB" id="2556652at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="633" mass="69888" checksum="FA8B6721D1937A62" modified="2014-03-19" version="1">MSAQRSQDDMAASPAARQTAFSFGALAGFSYDPCSGFSPPAQDQSFYSRRPASDSSRNTAPGDMTPVRQNSARQGEPRELEQIRASEPYSSEQCVSPQLIVPSQAARRPPDHGAQVSQSANSSMVHDPTVSQRSETSRDNATRVSQRLTLDEDNSGSIDTAQSQTPPPDITESYERTVISISSESEDQLSSSSDSGSDSDSDMPLNVFRRPGQAFVTTRSAELLHQSSHDRERQESNLQAERPASTPAPEDPLPISAKSPQSPDPGPLIIEHRFQRDVNWDKKCDRCRDEGFRCYTAQNTTSWAKSCFLCYQDHKICAIDGVRTHKGRSANVHPSQKKPKQATAAKSPPKQNQRTSARLSKRKSDVSSSQSAARHASPELPRTRSQKRLKQERREDEEEDSDANDTQPKARKRRRNGTFRPLAESEDELADDPPSQPTGSDDQPSSKDQQLREKRAPLCNSGVSNTDPTVSEPAGADRAVNVHGKSAEKLASERGLGPFERQRLEKYASMLFKDISTAVGRCRERVAEMSDDAGLLALESTLEVLVSDLAKLTAVDHQANEAAQVYWFVPQVTEYLQRIRLECQLVQERQEPPAAGPGWTGKELKARHVASALACETLFDRCLSLISMHENEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNU8</accession>
    <name>W3VNU8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNU8"/>
    <dbReference type="HOGENOM" id="CLU_028723_12_0_1"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="263"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="487"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="562" mass="60797" checksum="0B0C670B331E5DD5" modified="2014-03-19" version="1">MGNAEARTDLHASGSSEQRLEEPCSVKDPRDPWRMALSLAHLHVVLPRIEPVADSLYFLPAQAAALAGGRVGRLSARGSQGTHSSFTSAHPAFIAAHSLSSRLADVCAAECRGSPLRYPQQPLQERKPARHLGPASGCHLRIVFGQKCSHWQRGLASLVSPLGRGEPSPSNSAKWRRNYVSTPNAAPQQGPSSAALEVQNCKACLCALDPCISPPPLGLWEHNGTLAHRLHSALAMSHFRPQARGWTSFLRRPLMVRAARTSAVTLQVVCTIHLINEHVFEIRNSTGASMLPTLAMEGDFLLQLRLPLSSFLTSLTSAFTASSDDTVRHPYHGKERIGGSMFSKQDQAQGTGLRVGDLVVALSPFDPTRTVCKRVIGLPGDTVCLDPRMRPLPMHAWRGRGPHKPQPKDQGLGGKLVRFQDIISGGDSSPTTTSAETEKELGSKMVKYEELLSSLGVPTQPPRGEVDVFASMDTDAAQTEEATAAHNTAALEDLEHSYVRARGDVQYVTVPLGHVWLAGDNLANSTDSRHYGPVPLGMVRGKVVARVYPNPRWLGNNLSPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP35</accession>
    <name>W3VP35_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP35"/>
    <dbReference type="HOGENOM" id="CLU_176397_1_1_1"/>
    <dbReference type="OrthoDB" id="73348at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045230">
        <property type="entry name" value="MBS1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213">
        <property type="entry name" value="GEO09665P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="106" mass="11794" checksum="743A6CEDEAFD93CD" modified="2014-03-19" version="1">MSEDTPFHTGLFLPQRWSLCTAPPRTHNTDWKMVRGHAKQAAQEAAKKKADAQKGGKSQLGEARAKGLKFTCPTCKAQSPNYKVLKEHFDNKHPKDTCPPESTFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPB5</accession>
    <name>W3VPB5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPB5"/>
    <dbReference type="HOGENOM" id="CLU_1856138_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="138" mass="15058" checksum="DC67C2A6D91A8F87" modified="2014-03-19" version="1">MHLRQPNPDHHPGPERLGLCGKREICTSSLVESGGIGRRRQLDAVKASARSSRRKGVRRIKLDIAKAIRLSTLNQMAVDKAAYAAQRSLPVMDAMHEQERFSSKSFELRHVQKAKQGFCGPLGSGSPPPPAGIASSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPB8</accession>
    <name>W3VPB8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPB8"/>
    <dbReference type="HOGENOM" id="CLU_073102_0_0_1"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="256" mass="29211" checksum="65D1D2605111DE16" modified="2014-03-19" version="1">MRINRNAVLVGRRSVLVPYRKQHVPRYHEWMKDPLIQEQTASEPLSLEQEYEMQQSWAVDEDKLTFIILARPDTGSNGNEDKDTIDLLPNCTMVGDVNIFLNARHEYDDEDEEQARKDSSSQPADIYDAECEIMIAEHGYRRKGIAREALKMMFEYVTAAPTPTAESGKMPQVDKPSSHCSLPIPPEWLTCKISLTNQASIRLFESLGFPRQSVSEVWQEVEMRLTDNSRALPRQDGGTSSTSSSSILQVLFWQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPG7</accession>
    <name>W3VPG7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_02410</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPG7"/>
    <dbReference type="HOGENOM" id="CLU_028376_1_0_1"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS62676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="373" mass="42757" checksum="4FC1D701EAB97E25" modified="2014-03-19" version="1">MSAPSVDAQVLADKAQLKIQKRKRFEAVFPLLVEELTAYLASENMPAEAIEWFRRNLDYNTPGGKLNRGLSVVDTVEILLCTDAATGKLSRELTEPEYLKAAILGWCIELLQAYFLVADDMMDASVTRRGHPCWYRVEGVGNIAINDAFMLEAAIYFLLKKHFRSEPYYGMLLELFHDVTFQTELGQLIDLITAPEDVVDLSKFSLTKHHLIVVYKTAFYSFYLPVALAMRMAGVTDESLYKQALDILLPMGEYFQVQDDFLDCYGTPEQIGKIGTDIFDNKCSWNINVALQNATPEQRQILDDNYGKKDSECEKRVKDIYNQPNIDLPARFHKYEAESYQQINDLINSLPESQGLRRDVFRSFLEKVYKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPQ6</accession>
    <name>W3VPQ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_01766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPQ6"/>
    <dbReference type="HOGENOM" id="CLU_020019_1_6_1"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS63480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61173" checksum="C32CC92DFF06FD6B" modified="2014-03-19" version="1">MGCNRDRTPAGGSLPALDSLYLRSLGLPCIAHVLTAQTMSPELGPKAASSSIYSNVETAVMLKDLVARIRLPVIGLSRPCTCLANCGDDDTENMATGKLTRAASCSLRIVPDLAPIRKAGVYYWHPTSSSGLRWIDTTSQRFYTSFEMSSVEESGAQQGRRLSTDTAYSRRSRFIPFYHHRHHDYHGERRHRRRHFGKPKFSGFQPHFMAGLGEFIGTTMFLFLAEGGAKTAQLSVSATQTQTATPLSNETIMFIATSFGLSLLVTAWMFYRITGGLFNPAITVALWLTGVLTSRRAIILFIAQILGGIAGAGLVLGLTPSNSVQQVTTTLQPGINIPQGFLIEMLLTSILVFTVLMMAVEKHRATFMAPVAIGLTLFACHLFGAVWTGCGMNPARSFGPAVVAGTFNSDHWIYWIAPLCGGILSVIYFSFLKLLNYNSVVLDQDSDTEITGLKPIHVRVWNFIRHGQNPSALNPESSTHYDKEARKQFDNEQRQEFEEREAMRREMQDKPVFDSNAGEAAMGNFSPPQRNADVMSTSTGSTAHHSGQNHTGPILPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPR0</accession>
    <name>W3VPR0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="13" type="ORF">PaG_01845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPR0"/>
    <dbReference type="HOGENOM" id="CLU_022610_2_2_1"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="245"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="373"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="408"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS63549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="686" mass="76276" checksum="AD09D1EAC7B0883E" modified="2014-03-19" version="1">MLAAKKTCFPFAFRPPHPSRSSSRIGQSLHRVQSYMLARSRLLPIIRRTILAPASTQLSSNHLARRFAPSGTTHPLARRSMSASMSTTRTAMRQNKMTVSAPTSVPRLRGDEPQLQTMQDAEKLLEQLKPQFTTKLHLQAIGLTGRQLPLVTKDDRLLPHLFNAAGVRYVQPHPNGDPAHRIVLLDVPSSSPTPSAVLELLEKHKFELVGDIPLELGYDHLSSDQVLEALLPTEIVAAEGVPSGFTIVGHIAHLNLLDIYLPFRFLVGHVILSKHAGSLRTVVNKLDSIDTEFRFFKMELLAGAPEYTASVSESECTFEFDFRSVYWNSRLHAEHMRLIKRCRPNQVLADVMAGVGPFAVPAAKRGAWVLANDLNPSSHESLARNARINKVVMDESRADGGLVATCMDGREFVRWAMVETWKRAFRGRPKGYDAQDSVAEDERLRESVRKAAKDRAKKLRDAHAARAASKSLGEVEEATSRLAVDGAVVASLADVERWEARRLVDHFVMNLPATALEFLDAFRGAYTHLATSVGVEEVKAEMERRSASGDGSMTDVPIVHVHCFSKDPFQPARDILIRANTALGITNSEHRLRCKPIPPPPQTLAALRKSPAATATYVSSHPDYNLFQNASTQEAFMQIVNQQWQDLDEAIHTPGLEVHYVRDVAPNKQMYCLSFPLPRQVLWSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPT2</accession>
    <name>W3VPT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002060_1_0_1"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="963"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="1089"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1251"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1358"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1362"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS62781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1392" mass="150202" checksum="AB01F62F03164216" modified="2014-03-19" version="1">MASSLLLLIASVEPPPRLPPSAAHTWAQTWNRTLLIARGGAAGLYHHPASFLRFDKEAAQQLPSVSTHSDSGSSSSSSSDERVIQLARSRNGMMWATLTTTTISLWSARPAQVVAALVRTPQSIADYGNNSGIEWRPDGRALLVQTDRHFLLLYNIVYRHHGSAVYSYVPPSGSGSRSQSGDLLAPNPNALRNSFAPGAGESAAAGDTGLGGLAGEACELRFRLVLRIDAGLRFATSTETHMLVSTCSPSAVQCIRWPDDDPQAPPPDVKDPTMRTRTSLVSQLAWIQAHSSEPPDVQIVNITYSRPMDVFVWITADGRAYVANLDLMAQGASPWTGRCFHGARKARRPSSLAPDSTLQASTVPISSDDAHASPNAEPAQLPSDSPDTSGEQSSRPAVANEHPQAAPLPPEQHATSVSINAKFSLIALGLADGTVAVYNYRAPGRTPLLSHSISVREALKSTASYLTTGPVRSLAWTSDGYGLAVGWQKGLAIWSTYGKLMGCTLREDWELASKNFADAFMFGTADLFWAPGNTQLFILAAPKQDSAPLLPDNQLFILPFSKSAVAGQHSPDNTRFAFYQTDDSLHVYRGADQTDLTAITPESDVWQHIKIPQSYLAANWPVRYAAISADGNLIAVAGRRGLAHYSSASGRWKLHKSVAQEQSFVVRGGMQWFQHVLIAACDAGGEYQLRLYSRDTDLDSALLLDLQVLPSPVVLTSLFDNSLLVYTADNTFYHFLIDLTHDRIRLRLCGSITFEGVVGEPARVRGMSWMIPEGQQRLGDPIDDLTVATIIFLIDGKLVLLRPRKLGGARSGTASKMLQDFDDPRHDADGTFDDDDDEVAYDMQILADKIEYYWTHLQGIGTLENSLWGYDGSGIRLWLDALRIPSSQADDEGSVDDDDDDERDQLPEYKTIESSVSMPLDFYPLCVLLEKGIVLGVESEVSLRRSLDFALWRTCTNTHLFLHQLLRNYLERGLCDDAVFFAASYQDLVYFAHALEILLHAVLEDEADAGLGDASYLRKASGSMLEKERSSTSLLADVAEEQDDASVVKSSANGNGLRDGSDEEGNSRAHLDLPVPRHARSRSASPGASGTATPRAVLPLVVEFLDHFPEALEVVVGCARKTEVARWAYLFDVVGAPRVLFQKCIQADQLRTAGMYLLVLHNLEPLEVSIAHTIQLLKLAAQKQDWSTCHDLLRFLASIDPAGGALRLAVDEAGILGGHTVSAGVTGEDKSVELQPPPRLLRAASAPAVSAATALESMQEEDEDEDAGVGTDVPGESGEGEGDTVDAVVRPGLQGMRSKSASMSTDAARSVPDVVINGQSLTPGLAAMGIGGSPAAKRQYAHGIGMSLSRVGLRSSDRIWDPTASTSPTSPRASFGSLPRTSLTDEDGGPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ18</accession>
    <name>W3VQ18_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237003_0_0_1"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19117">
        <property type="entry name" value="AKR_AKR3A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044489">
        <property type="entry name" value="AKR3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1142"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1251"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1398"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1586"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1711"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="749"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="764"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="862"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1026"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1251"/>
            <end position="1262"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1398"/>
            <end position="1410"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1437"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1454"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1638"/>
            <end position="1650"/>
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        <location>
            <begin position="1719"/>
            <end position="1736"/>
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        <location>
            <begin position="1752"/>
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        <location>
            <begin position="1786"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1799"/>
            <end position="1812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1846" mass="202084" checksum="EF98D21CB27373C7" modified="2014-03-19" version="1">MPRVALQSHAARASAQSRQSIDTHTAAHVDLNCRSPTPTLDLPTFWSPRTKVAAALYARLGGRPVPLLRSAGNDGKSVRKLAKKILRATLLGVLLLTSQQLGVQLALRPPPPSTRLRTSLSSTLTFKQPGSTIIMSQYPSVAPGQSTFKLNTGAEIPVVGLGTWQSPPGEVAKAVEAAIRAGYRHIDAAWIYGNEEEVGQGIKASGVARSELFVTTKIWGTYHRQPEACLDESLQKLGLDYVDLVLVHWPVPLEKRGDEKIPLNPDGSRALDRDWTPEQTWEQMEKLPATGKAKAIGVSNWSVPYLERLLAKAKTVPAANQVELHPFLPQHELVKFCQSKGILMQAYSPLGSSGGPVLQDELVQSIAKAHSADPAQVVVSWAAQRGVVALPKSVTQSRIETNHKLITLTDDEMLKLNELHQQEGKSVRLVSPNWGVDLECVNVVNVGIGSTRTFVPHRSAQPALVTHELSSCGWRADLGLGFRVHSLFIRLHRHSQHNTLHQLSSRHHPHLGHVNSCRIMVADRVGTSSLERRAFEGLHGVGGSASSQSRDPPPRTKVPVKINVPRDGSTKHDDDDDCIPFRPGSSKRARPARKSALPTHNYSYRDNLDSEGTETAIRTGSHADRRKQAQSSRSPRSQHVHSPTDDRAALHRTPSHTYKSKAKARERDPASARRPATRSRKHSDNEPVVIDDSDDDEPVPTSPRPVLVADDTYIAPALQTKDRKRNGATTISPAAPNNFYFRNNQRPDGPLRLESPNEPRRSIHPSSHSKPMAQPSSSNQRPAGTIASRMKPKNPSPEASSQPSHRLLNGSAAHESASSRQHGNSGERAFASDTSPASKRRRTEKLHDLPDGTKDDPLRSGPHELSLDAVVVSDIWRSQDGQQLGARFIKNNLYLFPAPDFILSIRYTDIGRVEHSDDDVLEHAILSITLRQGSESVKRLLELFPAFDPHASQEASEIHLIARGVTTNVEALIAAAALMRRAMGDECKFSYLPPPSTATKIRAVTSVKAKPWPKPTPLSHVEASIQAKQQKTTRTAIRPGEGRRPDVDTSNTPSYRGHLSPPQPRKKTFDIQAESPKSKARATFDVDMRDASSPSPDPELPISVRKGKRASLTRTRVQTRSASNAASHEPMLQYPYEGIGAVTLLRSDYDRLYDGQLLNDTVIEFGLKVLFEDICARNPELASSMHMFNTFFFNKLLTEGTVETAYRKLRKWTSKVDLFSKKYIVVPINENYHWYLALIVNPGHMLTAHGTDGDRDHEIGSDEEKEQVASALDTAPKASASLSPGGEWNQSKPWQEEDAILTPPLAPLVIPTPSRDARVDTVPAPMHLDADSRASTPSKGASPSVDLSQTFLIIFDSLEGEHKNVDKKLYEYLWREALDKKRISPALFQKLAEEHAARAKRSAARNRRPLTRAQQQANQDAHVESAAVDVDAASPAAGTTESPMRKIQVLDTRQPAEAEADRPTDEELAKCLPKLQYILADVPIQPNFCDCGIYMLHYFDRFFREPERLLTMMLENRGPRTLTGKVSASTRNKQKREQKHIIEAEWQAGEVSGKRQYWRNKADELSELWKEYELQKQQYVDAVKQDGAADDEDMDVEASTPPPRKDLELGAQTDAVGDTTASAPQAERGAERGVTDAEAAEAAEAAEEPTVEATAAHDAARPNGETALGDAGLGLGLRQAGLGLEESLEQVLSGRDSNEIDQILQAATEGAKGDMALETASNEQADVGPSSGTNVKSPPPLYEPFRPLSVEPGASPEAAGAAESAQTSPQQRTPVRFGSGFIDSLPTAQSWQDVSPSLERTHFASDRASRDTDDTDDADAGSSTSTPIGEVGPLSISSSVAVVDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQK9</accession>
    <name>W3VQK9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_02176</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQK9"/>
    <dbReference type="HOGENOM" id="CLU_278261_0_0_1"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="11">
        <location>
            <begin position="310"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="825"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="904"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="904"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="931"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1093" mass="115156" checksum="69516BF78752E856" modified="2014-03-19" version="1">MSVSAAEAGPSAFDAPLETVPALDTTNGTSSESAAATAAPRRGTRARKPTSKAAGVDAAEAAAVQETQQTSTRSAKKRKADELAADTAADPDPINNEVAQVFEGASGHASDADDDEDDKQYCICRGKDDGTFMISCERCQEWFHTKCIGITQKAAKKLDEYVCESCSRADTKKTSAKPSKRYKSSAKKKATSPQEPQDDEMESDDAQNEDEASDGDEYIGEQGENASDVEGAPKEEASSSTKPARTRRLQKQDTHASRAESPSSDTEMRSKPSQGARRPSGPAKSATGAGPKKGGPRKPTGPTDASTEDARSRARKVLATALEKIFATHGSESASEEEEETDAQRGEAYAALLEAELFDATADAHGSIRVVASRYKDRFRTFLFSLKDAKNTTLHSRIASGELAAAELAKMSNEELANDTIRQATEKARLDALHRSTLRAEEAGPMRKITHKGEVEIESDALLARDQPDKFQIAVDRKTDVHQRISESEPAIPTQGPTSPGSDSVKESEEGPEETGATTSERTATRNSAPAPDAAQGSPSRLNFGDVWARNADSKTQDDDQNDHETTESYGFDVGSPHDEAYGHEAGVETEGAATSGADDFIDSFLDGKDDHDADETTTSKDATQAAARSTTPDCEPSSLARHRFRTVIWNGLMDLPDIFAFKGHVKQVAGRSIAHAPRLRTKFLPDRPLLIAGRLPTKAAVDYLLQVANAARTEILAFALEPGAIKDGATQATESDRTSFDGILKHFKDADRWGALHVSSSVKGSLIKDFYVAPLRQEDEVPLWLDMTESDCLGTDWHAKRDRDMLILVAVVIRDSLQAELVKAERGGGGHHRSTTKDGAKPQQEKADAEAGEAYDPTAGISIPLGPSSGTGASAIAPAAPGASAGFGSDALQSLLRTLGKTAPAPANPASMSSPAAGASMMANVGGATPPGPPPPGPPPGPPPMLVPPSGGVAPNRSPLAGSWPPHPPADEAGAGAHWQPPQGYAPQGYEAHMPAPPGPAAGWDQGSGWNYPPGPGMHPPPGGEAPQPAPELPEEEYPGQYNPDYLAQASAGAGRGGAGYGPRGGGHAYGHGYGRAYGHGRGRGGWRGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQR4</accession>
    <name>W3VQR4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Double-strand sirna ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQR4"/>
    <dbReference type="HOGENOM" id="CLU_657423_0_0_1"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="SAP" evidence="7">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="418" mass="46996" checksum="99530A0213FEE919" modified="2014-03-19" version="1">MASSLTVDELRSRLDALGLDTKGKKADLRLRLKKALRNANSASPANAQTQDVDAEWEPEFDAFLVLDVEATCESTRKYRNLEHGYETGSFQYPNEIIELPVVLLRWNKDKRRLDTAGVFHSFVRPTFRPQLTQFCRDLTGVTQAHIDAAPTWNDVVQSLLQFLVAQDLVEDASTGKSHMHNFRLRRGVAWISHGPADLRDFVIKQSWISARPRDRDHGAPPVFLRGPLIDIRKGIASLYKWEQEIKADQSRAASSRSTPFLEFGGDDGFQVISAPFGSSPSPVREDVRSTGLSPHDQSLAGLLDLLNIGPFQGRQHCGMDDTRNIARLAVELARRIELASRGTQVLLSKSYEALDGNIETNAEVLELDKPTAGHRAAQMEKLTLRPNVRLDSFHKRFFWMGKCTGEIRWPFPPESEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR26</accession>
    <name>W3VR26_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_01348</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001287_0_0_1"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="12">
        <location>
            <begin position="1504"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="2116"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="569"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="802"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1188"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1574"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1697"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1770"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1219"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1774"/>
            <end position="1786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2217" mass="237871" checksum="8676AB134C90057D" modified="2014-03-19" version="1">MSAASAAAPDALVSTSDRTASGSKSKTKRRDSLSKSGKKREPTRQESLGGAVIRSLFGTLAFLFKRPVRLFRPVKLSSWTILEAMANREGRKLSLRYLRTLLRRENSNFLPHLLLPPLLFNTAIGFTLFEAYSITESRLLARSKRQASSSGTDAEDAEDEQEASAPTPKWTPLWIVTASGAVAGAAQCFLSAPLDNVRYIMQRNVSASDSRARGGAKAVTLISWRAILRAAILPFAPAVARDKLVQDVQKEAIEHSKRAPKPTLRARILALLEPATASRDAAESVSQRFSMSPEKRHEWEKRLKRWRGGVHGSGLALSLIRDSVGFGSFFFIFEVSRRCAFFASTSVDRMSAWFNARGLGVVRPGGETTQQDNSNVVGRRKSDDGMGRGDVHIEDAGRVSHWIREGQRNVTDADVSYNQSRTVQGRVVAVIILLVGGAVGAFSYELVGRPFELMRVVIWEGRKQWEQGKREPGFRSSARRSASTASAAPSRADAMGVTTLGRTRVRGARAAAQARAEAFDGRLCKRRADFVVLRAQNTMGTQVSRVWERAKLTRPPHPLRLGGRTVLHRPQVNGTAGPRLTSSRALQHRKTLKASTSTLPSHTVERQRRMQHRRTRQASPTLATRPGFLTLLIEHAQSTAQLDRKHSGVDPSKTSIPLLLLHTYFIAPFLPEIPKPVLDNELVRAAAGVDKRLRPSSGAQTGKTQTDLMERVSTVAQRTLLMSLASRRRSAESPEAKLKKNWIKNNPVNVSFANAKAGVAGGAKRAGGFGASDRSTLQKGTRYWASGRVVWSLKRLATPPKSVGVRLHTRSPLDSSSTDHRPLPEHRRSCRPTTTRSALHRFTGFRPPTSAAFADPSSLASTIMPAKAGAATPDPEIGTAAGAAAAAAAGPAWRQFSFFESSPVRDADDFAKPPAALRSANEVAAICQCQVRPPTSALASDAAAGSASPSEAPVSAAVRFDEPSASSSKAVKANKASRKQPCTLVGTIHGRIKVLDPDTLQELAAWDAFSSGAVAGRVTHLSSDARGRVITLGEEDSSRFPILRVWDIRTGRNASRQADSATADGAKATWMPRLLAEGKVQHGSRPHPIAAVSHTPSLSYLSVALADGTVLLIRGLESALMAASGNAGIASAGSSGRPTPAVALPKFKVVFQPTSSDSGAHEPVTALGFSEVAAPAAANASAQVKTASTATQTPAYEARVSHGSKGRKAALARQRDPRTGSANAATQADAATSASAVHLFIVTLSRVLRYIVAGKGAGGSPAVLDDVGGALGCAAVIPPRAAMPAASSGPANAPGLPLTSAPSSPGAAGKMVIARDEAIYVIGQEGREACFAYEGPKSSIHLSASQVIIVSPPFAPASSAGPVRSFANARESPLSTPSSRKGSMLPAEVAKITIFDLDNKLVAFSGTFDSGIRQVWVGTAGEVLVLSDLGELTRLDEKPLRAKLDVLYRKSLFLLAVNLARSHMQRASSADVLARTEALMGDIYQRYGDHLYNKADYDGAMAQYVKTIGHTQPSLVIRRFLDAQRIKNLTTYLQELHAQNLASSDHTTLLLNCYTKLKDVASLDRFIKRPHARASSRADADDAPDPLGGEGEGAAEDRDELPFDLETAMRVCRQAGYFGHAAYLAKRYGEHREYLRIQIEDVKDYGDALLYVRGLQADDAIESMAQYAKTLLGELPDETTELLIELCSGAFRPDPEAAHKAMRLQQRQAEQDKTNRGTAPKSAAAAYLSYLQVGGFGKQAHSTDGGSRTGTGTHTPAQRNSAALAAPYTIGDGSSAATRPSSTARPADGDVSLDDADASRAEAGADAAEGDDKMQAYAVPSPRIFFAHFIQHPSQFVRFLETVVLARWGQYVDMDAADRSQGEPLDDDAPAYELPSSPGGGEVDEVEQALRELGLDGRADDYEDAEVADQKSIWNTLLELYLTAGEAGGGGRERALRLLQQHARLPYDVSHALMLCAVEQFDAGLILLYERMGMYEDIVRLHMASSSATSSAQVVSALARYGGSQPELYGLVLRYLVSSPELLERHTPELLGVLRVVRERALMSTLEIVQLLSSSAHTQVGVVRAFIAESISATIAATEADTRAIDDYKASIEETLAEIGELTDSGGARVFQMTRCTACAGQLDLPAVHFMCKHSYHQRCLGEEEAECPTCASHQTRLRDARRRQADAAVEVIATANAGDQHVLHRAADVHEGAGFDKLAALFAQPIMGNALAAQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRI1</accession>
    <name>W3VRI1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_01463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRI1"/>
    <dbReference type="HOGENOM" id="CLU_017959_7_0_1"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="64019" checksum="46449583B664621F" modified="2014-03-19" version="1">MEAKPAVTVDEGSLATLPDPPARSFVGKVKRGVRALGTKDAWFGDHNYVALFTPTVPFLCKPDTTSLPFYSVNARLPIFLAFLLGLQHALAMLGGVVTPPLLIGSSSGANLGQDDTQFLIASTLIWCAFGTALQVSRNRIFKTKYYIGTGIVSVTGASFATISIALSFFAQSYANGYCPTGANGVKLPCPKAVGAFLGTCCLCGLISIAMAFIPPKTIRKLFPPLIVGMMLTLIGASLVKSGITNWAGGSAPCATNHAIKCKIGSRMQFWGSASLIGLGFTSFITIILCEIFGSPFLKSASVFVGLVVGMIVAAATGYFNTTLMHNAPAGSFLWTKTFPLSIKPELILPLLAAYVVIVAETVGNVTASCDASRLPMEGTEFESRIQGGMLADSISATLAGVAMVPPLTTFSQNSGVISLTRNASRTAGYVCAAILFLAGVIGKFSSLFVAMPSSVLGGFTTFLFGSVAVAGIRIMAYAKWDRRARFIATSGMSLGLASLTVPSWFSYFFTYSGSNTGLKGLIQAIVLIVEEPYLISSLLAILLNSILPAEPEDEQAAPLLEDDSASNNGSDAKIVSDLPAAQVPDLESGTPATEAAKKAWNHPGTFFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRQ5</accession>
    <name>W3VRQ5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRQ5"/>
    <dbReference type="HOGENOM" id="CLU_017519_1_0_1"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF3">
        <property type="entry name" value="F-BOX PROTEIN POF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="290"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="733" mass="80825" checksum="0A2AE791176FA252" modified="2014-03-19" version="1">MKAIDFANTRPRQKCTVRSSPQQQAEAQCKAQPYKVGSPPPPSNARAHHHNPATRSSPPHNQHHCQPPPDHLKDAVPAHKAQPARSPLEARSDFHQLPVPVLPKRAPDRLQDARSQEPRISHWTRAQRYDSANWIRAAMNPLELPLPVVVDNLLPLLSNADLAALRSVSKHAKALVEDEVLWKRKVLADFTFPQHATARMGGWLNLYRGLSNPHVYVWGQLSQGRLGLDLDQLDGDVARDANSIHGGIPYPVRLTAIGSASTQRTLADDAGAVVEIVAGGWAFHARTSTGRVWHWGTMDGETFAGPRASMRDPGSKVATPQLMHGLPNVQSLAGGRCHAVALSTDHELLEWRAWGSVWKLEDLPASITNPSPAAHAIEGGQAPKSNIKQLEAGWSFSAVLTHTGEVWLWYSDWTADEFQRKYYDGHERESMLHADPPGYGDQKVFPLRVEPVCLPRIPGEGDAQHIVQIAAGEDFIVALSASGTLHRIDLHLPPPTGNEWQTIRQAYALRRDDDDLGVVVHRLRMKRFLETHARWQALAAFERPESHPDFDPTWLARGVAGRITHISAHFRRFVVIVPVIHNDREVEDTLVLLGTPDSVQPEMVPELQARGVIKVVMGDYHYGALTQQGEILTWGAFSKGALGNWPAPWHLGSGTPDRTEVAEGDRGWLGNLVPMPRMLRGSRAPRQAARAGQDDVHDPTPIAIHPRGGAMPFAFDLAFAGWHSSALAMPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRT2</accession>
    <name>W3VRT2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRT2"/>
    <dbReference type="HOGENOM" id="CLU_427701_0_0_1"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="460"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="621"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="680" mass="74584" checksum="6E5ABA426747C6F9" modified="2014-03-19" version="1">MTTDAATTPRQTATPTSDRALMPTDDAIDDARMHSLRISLEDTVAARAARTSNDEVESDQSGHAARPALKHDQLSSEDYVELTRISHKKDDIERHIADLQSWSAWDPFLEVASYSTEPQVLLASNSALGRLSSELELRQGKCDRLEHDVQRFNVDDMKRLRKVAKATSKRHLSGPDTDLLELALSTIYALDKLLRLLRDQRAEHELTELRLRWERALLASWQDVAALRSDIQAFVRKCRGLKEALLHSQDGHTTDAALLQSNETLNVDEIPTTSNQAAAESAAHHPSGAGKRTEVPTPALRLAAESVKLESSRLVLRVRSFDAEKVRYAGRLLDLLIDHRQVPEKLLDEQEKLEDALMRPAAIEAEAANIATLLEKKTSGHLPGSSSTTDLSVKPHRSISEPLETPRRREVREMRSTKDEVSPSVASSSRTLHSKRLTGAFSTPSPKATRDAGVNRYQADPRNKLDTAIGRIVNRLPMPVSIISVQAANRSASSAAKDEKDISGRYWIGDPEPRLCFCRILPSRTVMVRVGGGWQELSEFLTQHYSHLSLPNGEMHSAMLSPSKGHSASSLAWLRSASGPAGSPAAKSVLSMGSHRSNTSARKSISPRVSRVVTMPVDLMRHSASKDGGDKLKRQTSNGALRHRRVDSGEEIGPSPDAADSILTSGSQSSIVIHPSSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRV2</accession>
    <name>W3VRV2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRV2"/>
    <dbReference type="HOGENOM" id="CLU_855289_0_0_1"/>
    <dbReference type="OrthoDB" id="2544295at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="285" mass="32184" checksum="805142FBB7EE0D47" modified="2014-03-19" version="1">MAFQGIAAALSFASPTSPARCRPGRSEVISNHPSSIAAMNPLISTSYHASATAHAYSHASFASGTVFVFREGELLDPRDTSDDELDHRFCAGSVFARILDGQLFVANTNSLLHHLKKLPRSAERSHTAPNWVYYSQEHNWIGDLFCLLDYHVMPSPADPLAQFKLVTADGQERLPRLPIKIRIAALRSDISQLSELLRRDFCTELLPDKILEHPAVFFRRRYRVIRAIQKLYTEHSAMLSPDDNIFFFRGCKVCALYDPQVIRFSQDLHAVFLRIFHGEDISPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSC5</accession>
    <name>W3VSC5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSC5"/>
    <dbReference type="HOGENOM" id="CLU_013988_0_0_1"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="139"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="745" mass="80222" checksum="BA4D8DC730D35B85" modified="2014-03-19" version="1">MPKASKRQKEKKADFQKTKLKLGKGKQAANNATDTSFKAKTIALPQQSINADKSGKLVNSRNLTVADLALQLRHYSAGVRRDAVAGIKEILTLHPSLMLSAAPQLIPELSRCIGDDDGTVRKQLHLLLAWMLPEIPQQLLGPYHNTLLLYTTSALSHIYPEVRLDAIKVLDVCLDVLPHTATSGWQDAVFNMSKASTSTAANPVAAGPSTSAHQPHGERIMNCFLNLLGVTRRSGNAVSITATDLAPAAKLLILRSLRTFLSHALPATSSDGDAHPCRCPTWFFRSSFPSTAEFEHFESLLGKHTSSNRTRTLSVFASAAKDRSHPDVNSSSTTQASLPHWKDSEMSISTLMDLDSTSGTSVQQSDLYASLQAALSLSASAGNGSSGSHAAQSAALALYELLDPILLASFLDTAPAAFQPDLDLSHQVRGQNVGLSTPSQLIFEIIQLLLSLWRGASAPTSKARTSLANLLGHASIYFPFSSHTGTSTLSHKAKSLVVQMDLAYAELAALFAINAADSQKARYKFNVDVQVSAVAAFVSELLAVPVTEQGTVSLGSVSGSATSVLDADTFHALLPTLWFLLGAEHETLLDSLLAAYQAYSTQHRVKPILFEFLARAYLLSKLRAQTPFTQAESDRILQTLLSGLPRNLWEAASNSSGHAFAGLQLELLHFVLLLPSRPATLEFGKLVPFYWVTHPTKKVSGPGPFNKLPSLLRKLALDNSVLLQDCDGRLDKAISSARQSVIQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSI9</accession>
    <name>W3VSI9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane mucin involved in surface sensing via MAP-kinase cascade</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSI9"/>
    <dbReference type="HOGENOM" id="CLU_303684_0_0_1"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833350" description="Transmembrane mucin involved in surface sensing via MAP-kinase cascade" evidence="2">
        <location>
            <begin position="28"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="92771" checksum="7DD1C5B739EBB36C" modified="2014-03-19" version="1">MVAFQPAFKLMLVSLSLVFALANDAHADAGAHAPAAVRRHAGRAARMSKRFPPVAASNPQAAQLDKRQRHGIFGLTPEEIDQILGNEPIDGDSTYPSSNSTNSTSTSTRRAPRTHTRSATDSDSVAPTSTASLRSFALPSANSTSTSHSSSTADPTDSTHSFASSHAPSSTSSRSASSPTSSASSSNDPFTDADADPTSSSPASVATASPTSSQNILGGLLGGLLGHSTASSSSDAPSQTSNGQQGSDDGDTASSAKTAPTATSSVDSGDTDGEAPTSSSRAPKQTQPDFYSFTPQPTSSSSSLAPTSTGLVGSLLGGLVPSSSASASASPTPSPTGTDSGSDSGSDSDTASSTRTTQTNAPRPTGSADAGSATDTNSSDSASSTSYGAGSGSSTVSDSPTATATVTDGPSSTTQDSASVPTATGTATASQSDSGSASSADPQSSSSSASSDDSASSSASSTATTNPYWYANTQSLKMAPSSTSSAASPAQTGSDSSSSGSTDTSTSASDGGSGSTPALQDLPTTIVPSADSYTQPPDTTSIGLLFKQDMKWTWVISQADLTAQIFAFMPDLVGHSVSLDSSKVSTVKLASYSPETGSGASAASLSTAKTLYMAYVPSSSVEDLQAMIANTSSPFYTSAAPGAPQQLASQVDPTFNILSVAGQVAAGAKQNSTSGSGKTKDDSTLRNSLIGVGCGLAACLSLVAGGVMWRKQRQAKEDAVGGGNTGVSRAQTIRSFSGGLRETWAPDALDQHRALGTGGEMQQVWMADGGPAYVSSGHADGFGGYAAADPFQESAYHPEAAGAYVAMNRSSRMTERSHYSDFSQMTEAQRIQYDYESSRRSFHSTSEHSGTHSENSNESAGMLSTYQEDYRVPRQHTTNHAFGARSNSVTRSTRRRGSVASSTIGRPEMMSNSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT43</accession>
    <name>W3VT43_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT43"/>
    <dbReference type="HOGENOM" id="CLU_085439_0_0_1"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000065">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="240" mass="25882" checksum="416DB317A2F76E03" modified="2014-03-19" version="1">MSSRKSTVTTQNGRGAADKRDAQRDAPREQLSTGLWLLKHTQGIVTTATALGILHLRTSHVLYFTIGSLATSFTAKGLKRVIKQPRPPGSRVKKTSGMPSTHSATISFMGTYIMLSSLLLPLHPSLILDRTSTQSDQMVRIWLALIGVAAPVLVMWSRVRLGVHTRAQTLVGAALGVVKAIVWFTLWNGTQIMTGTSSAPVLDAATFPSTLQVGLRATVGTRIDSLIRHTEATLRDASGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT82</accession>
    <name>W3VT82_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">High-glucose-regulated protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT82"/>
    <dbReference type="HOGENOM" id="CLU_012229_0_0_1"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="711"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS64705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="991" mass="103775" checksum="0752FEBFA9E82B72" modified="2014-03-19" version="1">MSATPPPHGGTSTPATDADMAAQPAANRWGTVSGGLRSPPPAPSSGAGVRRNHTIHGARHHGKPRLEKHFEQPEDYPASPSLDSNAAQAAAPHTDSSADAARSIDASADLLSSPSRSSDTSAGFASSLTPLQALYSKSSVSRNLSLPSRHSSKLAANLPSSATQGRNSAFNSLSAITGGSDLDEHDWEKMIHSSNALGDEHHQDPNASHTHLPWSSSLFSQAPSSHPASPTARSELFLDTHPRNGTTAIAGSFDPASATADPAAARASTGFVRRHQSLNHHSGRTAAHRLATRSSGLNSRFAGDDADVLGHSDPVFSPARPTASLSAASSPVMPTSFSKAPWNHPSQDPIGSPSRFAASFPAHNLDGTHSRMQSGLDAPSSSSLLEIGDTLSNLDLTGSSPARAGEDLFDIPPSNAASASHLAHSHAMQPSLSAYSNDADARSASAKRLPQLVTTREALQGAHRAAPSNSLPPGPLSASAFVPPIGHAHSRNQSNDPNGSYAPLFDPVSSRLGPFTAAPTGTWLDKDAITGRSDAGPGAAPMPDSQAWPMQASAAPFASMGMDTNVMALSMALAQEQQRNAILQAQLGARHAAPGMHEPHLFGMQPIDLHANTQSIGQQLRGAPLPGSPPVGNMTNLPTRGGAFQMQPPLPHAQYRSPPPAHAALGRGGAPHGPAQDGEADAPTPVDPTSLAIEKGYNPAPGTFDLAPANARFFVIKSYTEEDVHKSLKYEIWASTDKGNQRLDKAFRESASNGPIYLFYSVNASGHFCGMAQMLTPLDYATSSNVWAQDGKWKGTFKVRWIYVKDLPNNQLRHIRLTNTPECKPVTQSRDTQELTPEAGREVLRIMADYTHKTSLLQDFNFYEMQGRAGTQPRPAMGSPAISMAGLPPRNSPKPGASPALAFGLPFPTSPDAAYAARNAVSPNAASRRAPASATPQRIQSVSGLGLAPGTPRKPNRIPDTDPKLDAAAQVDAQKSAIETAHSAGLAPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT85</accession>
    <name>W3VT85_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS64026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT85"/>
    <dbReference type="HOGENOM" id="CLU_346859_0_0_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="7">
        <location>
            <begin position="120"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="814" mass="88207" checksum="64887DDDCF8A34D9" modified="2014-03-19" version="1">MRSSWPSAWGAARFSDCVLARSYTSQNPKRRVQLGASSDLLIFQRVFPKLPHHDSQHHTTHALVVGSMSHNTGGQHVPTVNRSLDKPVYGNFHRYYHIRNPAGLDSSASTTDVHPALALDSRVAAILSYLSTLPEGLHSVTTALDIGCNVGKLTIQLAQTLAGQPESGELRPICVTGVDIDPSLISQAREAAARARSLYRPNEQLETQQAETASHPASVAAQPHLPVDAAFFPSVFPLLFGAVPAPRRINDRDKADAETKKDSVHCAHLCAPQLDFVAAEWVNLHTSDAPSPFHYDPHDLSRLQAADSAGYDVVLALSLTKWVHIQQGDPGLVKLFARIFSVLRPGGHLFLERQEWRSYHSAHGLDPTMRSKIKTLQLRPDGDFEWLLDSLGLTLVETIGYGTGLGFSRPLQVFAKRKETASSLATTPQALPSIGLLSIMTCPFAKFAGILPASAAHVHALHGLDAAPISDTNARGLSLSDALRLGTARSHRAVEKSRGVSLLLQTTATAADAADEGLSFDRTDYTRFNIMLACIYTVLESAMISAQSTPLIAPLFEDPGLMAGLARSAALLADVHAHLDTIHAHTGADLTDLADHARDDHSTSSTLPEDTEDPLARARLLVLVQAATPHALSLTRDLKVPVLGEEHIALLRPAQVHATLAYVERLTHIRPDLLLAHAYTRYLGDLSGGQHIVRKVTKRFPTPTGGFAFYAFHNPTHLKTRFRTAMHAQHLTKAQMQEVVDEANTAFDCNTALFESLLPAHWRQPSQDTHKSTAVHTGTKPTQLPIAAWIVVAAATATITAAWLAHSPSTAILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTX8</accession>
    <name>W3VTX8_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTX8"/>
    <dbReference type="HOGENOM" id="CLU_692840_0_0_1"/>
    <dbReference type="OrthoDB" id="10630465at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="398" mass="41891" checksum="81A995E2A0DC30DC" modified="2014-03-19" version="1">MRSADRRNWCQQAGPSSRSTLPGSKAQVLEAVVVELELLKVQAGASPNIHAAASPAQPGGTSTDDVPGKDSAEGGTILRRIGRYGQEGGSAVSAQAPRIHSAGALGSASMGRRIESQTPTMLSILSAQEGARKAASADKILKPGRSRSVLRPHAGLGNGPSCFHPAYTFTPISAISLLVTAQKSQHKKASVCSRRAASLAQKDLFVGGYAVAAELHALLARQRPGLRWVDPGAEACSRLRAEVSLAKQSSRGHGALEALAHWPDAPRSASVFTLASRLGTAGELQFSARLHVDPLGQPSVVPIDAGLPRIISELRYVLATDITQSHSRAQSKADRSDVAPSEAGRQRGGCRPNSLQELSPRSPSPSAIRHQAAYSLISTIHILFPSNTPPYFDIHPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU00</accession>
    <name>W3VU00_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_00571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU00"/>
    <dbReference type="HOGENOM" id="CLU_008909_1_0_1"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.780:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="375"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="667"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="769"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS65113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="998" mass="109345" checksum="3573C83DA7A6CC5D" modified="2014-03-19" version="1">MVQPNHPTSEWSSLQDIFYRRTELYALSWGIDNLADYVVAAASNGGLIALVRDPTRLVSLGKASLLKPKILVYTAAGQLIESIPWDPSLRIIALDFNALEQLVVVLEEGSVRLYTLLSPCPASVDASAAPTTSRKRPVPIEATSNSYYTQHSLGVEATETGILDARVWPGGVVAFVGARRFVEWRFPGLDLDAEQGDYAGAVSLSGGGEYGFVLPSFDDDAVQIPTPELLPPFDQSNSNSPQSSSLPSSWAVLPPNVSQSGLTTVLIAQGQTLLSLTRSAAGPSSIDTACQDMRLSRGPFHVVRPSPNGKLLALMTADLVLWVVSSDFSRSLSEFDIRASEAYKDASLVDDPFQSLNPSATSSGKGGIGGSGVRSVQWCGNNTLALAFNDEVVMVGPFGDSIRYPYAGPTHLITEIDGLRIIASDRHEFLQKVSDVSARVFQPGSNDPAALLFEAAEQFSAKSSRADEGIRAICSSLPDAVDTCLRAAAYEWDLSWQRRLLKAASFGKSFIELYDPTAFVDMARTLRVLNAARNYQIGIPISYEQYTAAGPTALLSRLTAQNHHFLSLKIARFLHIRPDPILKHWARAKIARTKPALGGSSSAAAAAAEERLCADIVRKFSIATSLVERVGELGGPEDDGLVSAGPADAAPASKDAGSVDANRAASVSFAEVAWTAWKAGRRDLATRLLDHEARAIDQVPLLMNMREDKLALVKAIESGDTDLIYHVLLRLKNQLSRGDFFRVVQAPVSDALVASGAQPSAQSRGRANAELASTRQYLALASNLLEVYAKEVDRDLLRDFYYQDDRRTDSAILALEKANAMRDVSETEMPDKIFNLKTAMKFFSEDKERVLEAKLVDEQIRLLAFQQALEKEDGHRSQFTGLSLNETIRQLLFRNMSKKADKLRSDFKVPDKRYWNIKLDTLAQSKDWDGLWSFANSKRSPIGYTPFVVKLVELNHVQESMRFVPKIQDKSDRNAFTSYLSRLPSQIVANQLSDRFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU27</accession>
    <name>W3VU27_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU27"/>
    <dbReference type="HOGENOM" id="CLU_067676_7_0_1"/>
    <dbReference type="OrthoDB" id="4863010at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS65133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28988" checksum="83410B2504374B55" modified="2014-03-19" version="1">MSFVRSLRAVPLRALRTTPPLLLSRSMTSYQHTILHRTHPSVAQLVTELHAQSEQQDAQGTGISSLNSQEVQKRDFSSFSHKMIALEQDKAELIYAVLRNKKATRIFEAGTSYGVSTIYLMIASQAAAAAASAEKPMVWGTEKEDHKADAAVANVATALKLPKGTSDIPGFTMLRGDILEQTRRSNIEKNSLDAVLFDIWAELALPTFKLLEPSLKADAVLFIDNWLTGVEIGTYTAFKGYLEAQGWYVAAMPFKNGLGMAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUD6</accession>
    <name>W3VUD6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_01254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUD6"/>
    <dbReference type="HOGENOM" id="CLU_079409_0_0_1"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="77"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS64401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31196" checksum="0E8CFB403AAE5BFF" modified="2014-03-19" version="1">MQPDQLGNCHDPSNTPRWTLIIIIHLSPPEPRCAIFPSITHLRLPAQTQAFPPYYPVMNRLFGSKAAKPKPSLNDAIASTESRADGVEVKIRKLDAELARYRDQMKKMRDGPGKTAIQQRALRVLKQKRLYENQLAQLQQQSYNMEQATMTTENLRNTMATFDAMQTANKEMRKTYGKIDLDKIESMQDEMEDLIEAANEVQETLGRSYGVPDEVDEEDLQAELDALADDLDAEDVGADAVPSYLQSNQELPDFVDELPNHAQAEGANAEHGEALRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUG7</accession>
    <name>W3VUG7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUG7"/>
    <dbReference type="HOGENOM" id="CLU_565151_0_0_1"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS65189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="498" mass="55173" checksum="81BD2BC129E43D8C" modified="2014-03-19" version="1">MANLASHMTPRMDDRPAFVARPGEPEDAQEFPDVSGISTKIYHHLGVDTPFDPQHRLVTSYILPVPALAIFRIVVTIYMLFTAFVTAVQEGIGTITYFTSLSYWGDCAYFFVSAIHTCTFWYSLSRWNKARLASRGQGAGRIEMLEKAYPRNGVGRIDVARSKAAIDAFGTQLHHSIESELAYSPRTEFEIGSRYPRSWLSRSFSRPLQFCHTLLVSTVSSYPLVVMVIFWTVLKGPAPLGDSYSAFANVGKHTLNWALTMLDLVVLSRTPLRPWWHLVPILAILGLYLGIVDITFKRYGVWVYGFFNVQQFGVPLVVFFCLLLAVFAVVSLLITQLLMLVREVVAAKLQKSGGWGSAKAVGVPDDACIPTIRGPGPLGGGGKRTKPGHDIIHLRGRFPSNALVGDRSSGIVVDDIQIHALSIVGSELNVDEVKTPISRSTRPSIRFEGDDQARAPSRSRSRQADLPNPDASSSEAHLFRPINWRAEENPFASNDRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUI8</accession>
    <name>W3VUI8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ThuA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUI8"/>
    <dbReference type="HOGENOM" id="CLU_057383_0_1_1"/>
    <dbReference type="OrthoDB" id="3482285at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834895" description="ThuA-like domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ThuA-like" evidence="3">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="377" mass="40457" checksum="9AED715AC392CE5A" modified="2014-03-19" version="1">MMPTRKAVLLTCAALALVLSAAPSVEARKKMLIYTYTQGFHHYSIPTATKAVQQLAKTANPPIDTVHSDDPSDFERDNWLSQFDMLMFISVSGKALSPDGAEAMRKYIEAGGGYMGVHEACDALYEQHWYGRLVGAYFNYHPQITHATLDIVNRTHPSTQHLNATWRVYDEMYNFNSNPSKWGKQYVITADESSYADPVETVKQRASEQGSPHPIAWWKEGDQLTYNPHVKVGGGTDPTKQEIRSGTAGTGGAGRSFYTALGHTNAMWNDPVFQQHIMGAVSWLMDSPVLKSSSPNPAAGAVGSDYDPTAVPTSTATSPSASAAALDPFSTLVSGTPVPYSKSALSKNGAVSSLGASSLATCIAAVLASLMLSLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUL9</accession>
    <name>W3VUL9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUL9"/>
    <dbReference type="HOGENOM" id="CLU_015134_1_1_1"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="206"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS65308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="476" mass="53361" checksum="260F8D4EDA362E24" modified="2014-03-19" version="1">MAPSLFRAVRPASQLYRSSAPSSSRLLSTSVRRSLATEAADKAVPISPATSAYTAVPISPATSAYTVEELHSRSAQEILSEGGSRKDRSLRHFTVNFGPQHPAAHGVLRLILELNGEEILRTDPHVGLLHRGTEKLIEYKTYTQALPYFDRLDYVSMMTNELCYSRAVEKLLNIEVPERAKWIRTMFGEITRILNHCMAVLSHVMDVGGLTPFLWAFEEREKLMEFYERVSGARLHAAYVRPGGVAYDLPPGLLDDIYKWATQFGSRVDEIEEVVTGNRIWKGRTIGIGKVTAQEALDYGFSGVMLRGSGIPWDIRKVAPYDAYDQVEFDVPVGKNGDCYDRYLCRVEEFRQSLRIIEQCLNKMPAGQIKVDDHKLVPPPRATMKESMESLIHHFKLFSEGYAVPPGETYSAIEAPKGEMGVYLVSDGTNRPYRCKIRAPGFAHLAGADFMARHHYIPDMVAIIGTLDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUM0</accession>
    <name>W3VUM0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Asparagine-linked glycosylation protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PaG_00288</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257118_0_0_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="22">
        <location>
            <begin position="707"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="20">
        <location>
            <begin position="858"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="1188"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="1290"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ETS65219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1359" mass="149417" checksum="70AEAAD4530E65C9" modified="2014-03-19" version="1">MPTSIPLAQHIPTLIFLAVTVLTAALINRTQPTPYIDEIFHVPQAQRFCSALAHASPSQVWAQLGRIDYDPKLTTPPGLYLVSLALTKVLPGWKCSDVVWLRSTNLVLLLTLPVLVARIVEHSEQPPSYASAAKSAVQAKEKQNPVSREQIRALQDRAKHDRPPAPAPAPTRLPAAPSVPKRSQGNAALPVRLKRREASVYIMGVACTISMVPPLWFFGFLYYTDVASVWLVLACIVLYNRLTAAPSLQSLALAGTASLLAVLVRQTNLVWVGFAAGQATLAAVQPASKSSGLLVEVRDVVLLAFGRARGSTRFWTTLGYNVAAMMPMLAGAAWFVRWNGSIVLGDKANHQAGTHLAQIGYFLLFATAFGLPALVLSLSTSAQQGTGGTSMLTSVRGAVRTVACRAFGTIWRCMLTLLIAVLFWAAAAYYTIEHPFLLADNRHYTFYLWRLFRRSLGPVQPRFALVPMYVVALYAWALALVRRTSVLRGILLGCATAATLVPTPLVEPRYFVVPYVLLRVYTQPVEKEGAVKWVYLAAEAGVLAAVNLATVGLFLRRAVLRNTRAIAEAPLREVSQTPGFGTWRQVVRTARHQRRIQRCKAWQGEVRRRFMSAKKKEKSRNDPLLFGHAHITPFDAQASSATPQHSAMLFRLVTLLCVSTLWTGALAVSDITFSSSARRDHRPEVVVRHYTLNVTSTTLWQGCEPFGGVVVNGSFPGPTLRARAGEILQVRVWNFLADQNLTMHFHGLAMIQHPVMDGTTLVSQWPIYPGRFFDYRIPLTAEDKGTYFYHSHAGVQAMTAHGALVVEDPSGPYNDPAQLAHQEEKHPGSVKLKHVQGTKGLKKGGGSDGAGPYSWDEDRVLALGDWWGYSSLDRIHSQLNADPFAWPGSATKLLLNGQSTPLAAETCNATKAQLVGVDCKDAPACGAGVGWPEVQLDYGKTYRLRMVGAVSLMYVSAAILEPGSNRLQNMTLIEADGSYLAAQTVDRVELASGQRYSVLYTAPTRKEVEKDRSGGVHWMRIESRWRAGPSMWVKLTYPSARHSSPAVVDPPSVAKDARLLPNETFGWVTADMAPLRSGGGEEWWYADKMPRDDQVTRTVVIDTQQVKFYASKRGVRWDENGEVFDDTDVATPAPYLVRTMLGDITLPSADQFNTALLNPTSYNTSSGVQPIVNATSSELAAAAERRWAQAYDSRLNMYFARQHEVIDIVLVNRPSQLSSQVEIHPWHMHSHKHWTRTIHPGTFSFSRLNAIYASNPNFTNPIQRDTSIVYASPGAAYLNQSLPSTNDDGGFAVLRYKVKSNNAGFFLLHCHLQFHLAMGMATVWSINPAALNPLHANTHNIQGLDPAYLTPGTNVPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUM1</accession>
    <name>W3VUM1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUM1"/>
    <dbReference type="HOGENOM" id="CLU_040908_1_0_1"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000298">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833303" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="74"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="400" mass="45974" checksum="A47BE70B5A9B2D8A" modified="2014-03-19" version="1">MRISVRAIASLVLIALAAVSNAEEEHHRKHHKHHKKHHHHEAANTSVEPRGSGSNGHALGLPWGCDPSCINGVKSTKNTDFRWYHHWQDTRVADLDKLGFEYVATFWGPTKWDKWNAVKAELSRGPLPKYMLAFNEPDVQGQSDLGPKAAAKLWMKEMQPWANKGVKVGSPQVCWNMQWLEQFMGECKKLGCKISFIALHWYGSWREFDKFTHWIESVHNEFGLDIWITEYGITQASGGSQADIKNFHIRAVKWMRQQGYVKRSAWLGGFPVDQKPDPYPNSLNSYFNADGSARDLFWWAAHNAGGPMISLHGLSKRDEKEREDDKPKHEIEQYDEEHCDYKCQLRENSIEKHQRRKKGIVQVDDKHVCIATPSKLDRDERKKLAVCLKQVGLLQPSSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUM5</accession>
    <name>W3VUM5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ARL1-ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_00293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUM5"/>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04153">
        <property type="entry name" value="Arl5_Arl8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000728">
        <property type="entry name" value="ADP-ribosylation factor-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS65224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19828" checksum="AE6BAFCEB8BFE592" modified="2014-03-19" version="1">MGVAFSSLWSSLFGSKELKICILGLDNAGKTTLMYKMTLGSVVSTAPTVGSNTEQFEYKNLKFMLWDVGGQTSLRTSWTSYLASTDAVIFVLDSNDRERVNLARDELHRIGQDEQVAKAPILVWANKQDIKGAMTPAEISESLALTAFRERTWQIFGCSALTGKGLTEGLDWLAHTLGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUY1</accession>
    <name>W3VUY1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUY1"/>
    <dbReference type="HOGENOM" id="CLU_038125_2_0_1"/>
    <dbReference type="OrthoDB" id="526316at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834588" description="Alginate lyase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44512" checksum="3F1EA5ED24400E51" modified="2014-03-19" version="1">MKLCLTALFFAATTVVNALVRDVPGLNGAIPPTNLANVKFHKRRPADFQHPGLWHTHEDLERMRIGVANQLEPWYSAFANFSADVYSSSSYKMKGPFPVISRGSVSNYTSFTSDARAAWQNALMWYITGDDAHRNVSTSILDGWGSNLTDIIGTDRSLLLGTEGLLFVNAAEIMRWEANWTEQGATYKGGTGFSVQLYWLFARQSVIVGQANYGMASIHALLNYAIYLEDVSMYNYALDMLQNDPCAGLEANFDVKTGQGSESGRDQGHAQISIGWTALAAKTILSQGGDMFKEHNNLILRGAEYAGQYNSNKTVPFDPSFYRCEAVLVDGPWGTVANVSRGLKYPVYDLVYYEYIQRLRVDSEAIKEVKRLSPSESNVTSADLPSWGDLLWAYNSTSSSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWF4</accession>
    <name>W3VWF4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWF4"/>
    <dbReference type="HOGENOM" id="CLU_541970_0_0_1"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="348"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="503" mass="54710" checksum="ADA7556DDD718E8A" modified="2014-03-19" version="1">MRIATPKCQLDRPSEIEKRQAPTLAAPCRPCLDYSLFRCHYSAYANHGSIDERTLEYLTAKSRGRDPPRLSLSLAVATRRVLDRVHLVIHAYALQPNGGTGGRNCRDSEPLPVLLKCTCVSVRHYRPPSPRPAAPAATPTYSGWQWPHSVALAFVPAAAPSERLRLERGQQQHPPTRTLSQSVSDGPAASVSRVGASFTSLALAQIRRLLLAHGTRPRRIAHTTLAHLDLLWLPPPDRHFLPRCSRNDTATSCEMHATEKNRISTCSTDNGSVDAHGGASLAPVLSNQSASSVDPKKADCCSPVSVSVRDAADTQSPVTSAPHTRSSSHASAAASPSRSDNMPASAAVHLSTLLVTGQRKTWKFGPNETVEAVRNHIWNNWPESWPQPKPESSAYLRLFHLGHILDAPELTLASRGCKPGTTTVVHIIIRSLPPPEPTKVEQGKFDPTSSTHCRCTRRSDPYPMLANRMPSESPVKTTAAEPGQPRRGSRQQEDTPGCSCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX39</accession>
    <name>W3VX39_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX39"/>
    <dbReference type="HOGENOM" id="CLU_104295_0_1_1"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS65341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17189" checksum="F50E079C1C664BDE" modified="2014-03-19" version="1">MTWNLVTSLLRSAVAGPSRLPTSVRAFSTSSPLSVTLQQNLRGARKPHRPTVNKVPALESKPFVKGVCSKIFTTKPKKPNSAIRKVARVKLSNGRSVAAYIPGEGHNLQEHSVVLVRGGRVQDCPGIRYHLVRGAQDLAGVAGRMTSRSKYGAKKPKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VX82</accession>
    <name>W3VX82_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VX82"/>
    <dbReference type="HOGENOM" id="CLU_456437_0_0_1"/>
    <dbReference type="OrthoDB" id="2554960at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="74486" checksum="114BE24D5123BA5A" modified="2014-03-19" version="1">MSRRITDWFKPEGPKKRGGSPLPSRVPSKQHTGTATGNTASREAVLPEHASTSVTASALDPLATSTAASASSRASTPEPFPVEPHPSGALYGDTPLSVPRATDRAPEVVILSRNDGITTYTIQESKENVPIACRIDTHNEHLLLGSIFLSTKVVDGKTYHRVVSSHMALARIVAEKNPSPHADRIIVDHRNRMTTDDTEANLHWETPAFNTFNMDRKDSKSGFRGVQRAGRKYVVAFRGRERARFDEAEPAARLYDLLCRLQHGDQLDGLDGLLNSLPDQDKEVEKTESYLDGVAIWRVCSSFLVLHDEVEVASQHQTLTAARQAASSTASEVQARRFREEAGRAQRRSQLTIERNASQIAYFPLVNSRGEPVEALVDDSSWLDIRAAGIRVFITRADRVAVSGGGVPFTTFLSRWLRSATAAQVVDHVDGDIYNHRLKNLRATDRSANAQNARKDASRSGLIGVSQTHRQRWRVETNVKGQHRSAAQNFEAHEMELAIEMYDLVSLYQHGAGALLNRPHRLEVYLADLEDTETIKRVVQFLAPKAKVQYSDFAGVSVNRAKVKGKFYSYWNAQVRPTVPEGEKMKLKTKRFGVMEDKAGEVKAAIFYDLWRLKLKGVNYTINFEHMRPWYLYHLPTLSDDNDLRIIEKAYQRLGGDAWALAQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDP7</accession>
    <name>W3VDP7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDP7"/>
    <dbReference type="HOGENOM" id="CLU_010412_5_2_1"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="101" mass="11267" checksum="247241285C45A530" modified="2014-03-19" version="1">MGKVHGSLARAGKVKSQTPKVEKQEKAKQPKGRAKKRLLYTRRSRQRACESRPPSLHHEARSGSAIASLNLLWRKVVATRIFVNAVTTPGGKRRMNPNGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEC3</accession>
    <name>W3VEC3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEC3"/>
    <dbReference type="HOGENOM" id="CLU_047470_1_1_1"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF39">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44010" checksum="766BB97BD24B6455" modified="2014-03-19" version="1">MSPPTATTLAVPADSTIGSGVTVKTKTANKDGQAQVSGLVKAETTFHVDVDSMDPKVARSLIAAGVRPHDMTSNQILVGDGIMDPDNKEMLIQTISEVGSQGWEAVYDRMSVLLCKRNLPNVSNRVLLQTSPSDAYDTDKIVAHARKYAAEFERIGISKDRFCIKIPATGPGMNAGPILLKDGIRTLGTSLFSVPQAIASAQAGCLYISPYFNEVKAHDPATGLFPNVRSPATQHPMSPRMVQIYNVYRHLAQTTGKPQPLIKGASNITAAEVLGMAKMGVHHVTILQPVLKQLSELAVPVEQELEDRAALAFELEKFDEAKPYSRELIAEMQELEKVDPLSPTKVPLEWGAHIDYLADGGKELEKAIEADPQTKRRLDDALNLFIDAEHRARDAILAAMKTTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEH9</accession>
    <name>W3VEH9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_05893</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEH9"/>
    <dbReference type="HOGENOM" id="CLU_031223_0_0_1"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="143"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS59920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="445" mass="47435" checksum="DE3696B0BCF8DA93" modified="2014-03-19" version="1">MAIEKIQARMVLDSRGNPTVEVDITTEKGLFRAAVPSGASTGIHEAVELRDGDKNAWMGKGVSKAIDNVNNVIAPELIKSGLPVTSQKEIDDFLIKLDGTPNKGKLGANAILGVSIAVAKAGAGEQGLPLYKYLANLSGVKAPYVLPAPAMNVINGGSHAGNALAFQEFMIVPTGAKSFTESVKIGTEVYHNLKKVINTKYGIDATNVGDEGGFAPNVQSADEALEILTEAIAKAGYEGQVHISLDVASSEFYKEGKYDLDFKNPNSDSSKWLTGKELADVYLGFIKKYPITSIEDPFDQDDWEAWSHLRANAGITIIGDDLTVTNPLRIKTAIEKKACNGLLLKINQIGTISESIQAAQLAQSDNWGVMVSHRSGETEDVTISDLVVGLGVGIIKTGAPCRSERTAKYNQLLRIESLEPSAVYAGIDGFTQGETAPKVITNKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEJ1</accession>
    <name>W3VEJ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEJ1"/>
    <dbReference type="HOGENOM" id="CLU_045732_0_1_1"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="377" mass="42565" checksum="2C05DF3B2C2709F5" modified="2014-03-19" version="1">MSTSNLEMDDSFRVLSLPPTATEAEIKKAYRTLSLRHHPDKAGKDVDPAKAAARFHEINLAYETLMDPAARACAVQRNAQDAAKRERQQEYEGRRRQMADELERSEQEALRSRQDADRAARERAAKIMELQAESRRLVKRKQDEIDAKARQKYEASADKRRKDEELAKAEREPELHALDKTVRIQFPATQLSHLAGTPEGSIVPPEVPLSSPLANALANQFGELEHLQFQLPSAGKKLKREMMALATFKTLRDAWQAVETGGEMRCTGLLQECFIGWANYTKMQRGAESEAKEKVYVEPKRVRWYKDHGISRPRDIGRVRPTASYAARTEDDAPTASELSDASPFASRGGVYSKAYEAQTLQRLRDAARQSQAQTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEJ7</accession>
    <name>W3VEJ7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PaG_06067</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEJ7"/>
    <dbReference type="HOGENOM" id="CLU_008978_2_2_1"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="543"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETS60073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="733" mass="79823" checksum="B772EDC146419346" modified="2014-03-19" version="1">MGIQGLLPLLKDVQRPVHASSYAGKTLGVDAYVWLHRGAYGCAREIVLGDPTPRYIAHALSRIRMLQHFGVKPYLVFDGDKLPAKRGTEDDREQRRNDHLERANQLEREGNMQQARDLFSKCVDITPEMAFQLIKVLKQQDIPYVVAPYEADAQLAFLEAEGIIDGIITEDSDLLVFGCKTVLFKLDQAGNAIEMLQQRFWTNRQLALSGWTAVEFRQMAILSGCDYLPSIVGMGLKNAHRLLRRYKTVDKVLQAVRLEGKLRVPNDYAREFRKAELTFVHQRVFDPRTQRLVTLTPLPDGTHDDMLPFIGANIQDDVAIGVAEGVIDPITRMQIVDRVPKPLGMRSNSDNNIAAAPSTSAVPHGLHRSTTAPMTLQSSSTGVGVGGFYRASVGAAAKKKAVSKEAGLQSLKNFFVGTSVSSKENGRPKAEDRVKERAPLAAVDTNRKADASGTQSKFFAKATPAPTQTAKADHAYLHLGGELTPPVVRKGPNDSGYWDEECHDMRDFVRSSSPPQATAASQALVVETQEVAVATQSESMPSSSVAVVVPQTPSRGGRGSKRMRTESREFSSPESVIGSGFISSPATSSVRGDVGDEEAPSSPSPAQACAPATRPHRSEDEEDVQAEPVTPLAVRAGAARKPVLQTSVSKLEAFRYSAVTPQQAQQRQHPRETPTAASPSVLKLAASSTPVAAVRPAKALKRSPTLMLGDEAESKGLFDRFRFSDQETRHVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEU5</accession>
    <name>W3VEU5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_06078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEU5"/>
    <dbReference type="HOGENOM" id="CLU_056749_0_0_1"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS60084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51441" checksum="891F17D34EBEB77E" modified="2014-03-19" version="1">MSTCGALTSVSSAFFGEKPGAAAEAGALSCISSGAASATVTAASRLRALGYDPDELLQHYRDHGYIILDGLLASDTSSPLHLDSLRRLADTATQITRDGKWPHRRIVGNAFPPFTQNNRDSWGVQHIMNPQLDTAASASAASISSVFQQFYASSPLLDVASLLIGCQVEAMQMELFNLLVNPASHRFALGWHRDDIRPDVSEQEEEQRLETPTYGVQFNTALWDDDCLFIVPGTHRRMRTAAEVVANNAKAPPAVQVDSEGEVDKTFGEDGAWNGVDPPNTMRVRLKPGQTAFYSQRILHRASYLPTAKRATLHGCYGDASSGTGAAERARNVLQHGVEWMRDAQFGDSLPPVLKPMRTVFLAQVSTLSRTSAPLATLLCTTTFPFLKASAKMSQCPLGFTGTPPPGHPKVAGLDAKASEADTRDRHWNPWLLLAIDALFILAAIYVARNGVPRAIADPIANVWRKVPKPAAKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFK9</accession>
    <name>W3VFK9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CIA1</name>
        <name evidence="16" type="ORF">PaG_05831</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000536_0_0_1"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="entry name" value="AAA family ATPase, putative"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
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        <property type="entry name" value="Bromodomain-like_sf"/>
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        <property type="entry name" value="CIAO1/Cia1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
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    <evidence type="ECO:0000256" key="14">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="16">
        <source>
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    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
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    <sequence length="2252" mass="242834" checksum="19A1797C90057F9E" modified="2014-03-19" version="1">MATAPLHLVANLEGHSSRAWHLAWNPRMPLLASCSGDKDVRLHAYSFVSTTTAEGPSTSKQPAFNLREVIPTGHQRTVRQAAWSPDGKILATASFDSTVGIWERIQDIDGTAELEGSNGSRGPLALSNGGKHVDEPEWDCVGTLEGHESECKSVAFSHTGSVLASCSRDKSVWIWEVQPDAEFECLSVLMEHSQDVKVVAWHPNDEVLASASYDDAIKLYIDDPQDDWFCYTTLTGHESTVWSLSFSPCGNYLASASDDLTVRIWRRLNADECEARGVKPEGKMPGRRGDKWVAVTVLRGDHDRTVYSVSWGVDTASNRNGNLGRLASGGGDGRICVYEISASEDDKQLAPKVELVAKMERAHGSADVNCVAWAPESLNARGGGAQAKIEELLDDGVTPKSAGLSSGLTHQNMSDMLASAGDDGSVKVWTLTTSPLPPPPASASASMSGGSNNNQHPYTSQPHHSSFQSNPPSFHPDPQHQLFPHQHGYGYPSANQAAPDFPQPPFPHHHQAAYQNIAAQPDHAFSHLAPDFDASGTSYTGASNQLPLNNNFAQQLHQPQWDQQVHFAPQSGSEQLHAQAGYVHQPSSYPPQANLSEHPVADDIATPPPQHSQVATPSPPKSTLRVKLKRVTKTNESSAGGQQAQAQLQIEPNSNMSARPSRAAALNASASMSALSDSPASRSLRLRPAKKEPGSEEDYQDVSDHHTNDNRGSHPLRHAHLPNRDSGSISSVDSQETGEHIGEQKASRSSRSSSRKTFPVAIRRSGRNQSRSSSQAPTSSQTPTTSQSLRIHESRPPPPRRSTRRSGDSAPESSQEIVSEQMPSATQRLAGQTRAPSARRSSRRRDADAAEDDDEDADADDDAEGEQDVAVKNDDDDKHHEPEPIMSRSRSGRMRRMAKESMAESDDSEAGRDDDDDEDEEVVRSTRRTSRKLASNSLGGFVAADDEDDEDDEGEYGSRKTRSGRVLRRGNSSSSNRLQEMAAKKRAANGRGRHAKKVIDDEFEMDGDDTPEEDHISGAEDDPLDLHSDEPEGSQGKSYSLRQRKKVNYSLVPPPASPPRDGFGRAIRNNRGRAANGAYEIDPSTTGAAPGSGTGAALPMPFPGRGKKGKEGWDALPSSMTGKDYARIFGDPVDSSDDELQNNALRKPGGPAALGGGGAGGLLGAGGAGGAGGPPGGLTGSGGTDSFGRIKKSGDPLADVDPLGVDMNIDFDSVGGLDGHIQQLKEMVMLPLLYPEVFQRFKVTPPRGVLFHGPPGTGKTLVARALAASCSTEGQQVSFFMRKGADCLSKWVGEAERQLRLLFEEARASQPSIIFFDEIDGLAPVRSSKQDQIHASIVSTMLALMDGMDGRGQVVVIGATNRPDSVDPALRRPGRFDREFYFPLPSLEARKSIINIHTRKWEPPLDDDFKARLAEVTKGYGGADLRALCTEAALNAIQRRYPQIYSTTDRLLLDPASIQVDAKDFMMSVNKIVPSSARASASAAAPLPERLAPLLGNVVQDAISVLDRILPPVSKRNPLEEALWEDDTFVPNGLTSGMSAADMLAGDRGFGREMLLQSFEAQRVYRPRMLVHGEAGMGQGAVGAALLQHLEGYHVQSLDIGTLLGDSARTPEAAIIQLFVEAKRHKPSVLYIPGLVHWARSVSEGVKTTFKALLDGLTDADPVMLLGIAEAPLDELDDEVQSWFNFLDDDLVQIRRPDEESRRAFFKEIFDHVIRPPTEFPDALPRRKRVLEELPKAPPRPPRKLTQAELQQQADNDAKLLEHLKYRLGPVLAELRKKFKKFTRDVWDEYNLRELTQQFEWTREKGKVTIELRYYRPGLAGQQAREDDADDINGMLETEADVAAKRGITAAQFNSPEPSAVAAGEEAADAVGGETEAPSAAAAVAGETGDVEMANGDSAAAVNGSNGAEASGEASSAAADGVAPPSSQPNGVGAAHPNGEADEAGGDASTAAADTTGAAGAATDEYVTRTMPIWTTNLEKMQKRLYYNGYLSCSAFMEDIQKIVENAEEAAEVDQERVFRAHQMRNLAIVLMDQYIDAGFREECDRMALRQMAREQEAREATEKAKQSAEEAAKKAAESAKGERASARIAGKEVDAALLGDAGAIERGAKRQRSASAQADAPAAPAEGSEGSEGVEGGEGGEGGGDVVVVEGGVVATEGVEKEESRKRARVEPAPVHPPLTYTAASYVRLTHHIVASTATYSIDQLARLRAAAFSAIWQHRADWDRDELIGRLIEITAKSQQAVARERSIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFM0</accession>
    <name>W3VFM0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_05660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFM0"/>
    <dbReference type="HOGENOM" id="CLU_035750_4_2_1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000019">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="9">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="334" mass="36332" checksum="2EDC67BEA4F2C130" modified="2014-03-19" version="1">MQKAMRLEVGSAGPWQGGVEGVIGHFRRGLQQAQFVIFRLGQSSTQLARLQPPQPRPTDPNLHSLASSDPLSSLQHSASPSPVAMFLTRSEYDRGVNTFSPEGRLFQVEYALEAIKLGSATVGIATKEGVVLGVEKRVQSKLLESSSIEKIMEVDQHLGAAMSGLTADARTMIEHARVTSQNHAFTYDEEIKVESVTQAVCDLALRFGESTAGDEAMMSRPFGVALLIAGIDEKGPQLYHADPSGTFVRYDAKAIGSGSEGAQTELQDKYNKDMSLKDAEILCLRVLKQVMEEKLDQNNVQLATVTPRVAKDGRPSGQFAIMKEDQLQALIAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VFP5</accession>
    <name>W3VFP5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000037">
        <property type="protein sequence ID" value="ETS60374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VFP5"/>
    <dbReference type="HOGENOM" id="CLU_463964_0_0_1"/>
    <dbReference type="OrthoDB" id="3366627at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="58709" checksum="198C3EDEF706941B" modified="2014-03-19" version="1">MAIFGLKSRKSHSSVISSVSRHEPPRTSNTEAADVVGDSPDFGQVAHSRRATNYTVDSSSSSLRSRNSTSMKKFFGSTRRKGSQSIDAAAPPSHAAKSPDYFGSNNTKRASQISLVNKPTVAATSPPVITPGAIAPSLSSPAGDTSSFAEAVGAGVSGGLASPSSPTGAPRPSELFAGKGVQWNQIDLTSRDLTKPTDAASTNIDMQKFLKERRQWIPTFKDSDNVEEDAVNLPKSLDQFSFGDAPQVAKSSAGGLKSLKDLEDTHKRKAALLEKTPLATTANGTIFEEAATTPSPIAGPSAVPTLPPAPAPPSRNQSFRTSSFVGSNDNSTRKSNSISRKPAPSLGTSADTVSPAAASAASRDIPQRRSSVRKDLSELGGITAAKEPSETVGPAVAAAAVADSSSSQAIDPPQPVNGNGRVDQIKEQAAATEAAPTSSTANGSVRASIDTAGFVTPAESQTHDIQSAATERLRAAQAGPTQPASAIAGDASHDSAATAAPASPLQTDTPPRPPKNGQRTPSRQSSKDPINASPTKPPGSTFAQVKEQIAHAAPSLQNVVPGTGAATTPAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG36</accession>
    <name>W3VG36_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG36"/>
    <dbReference type="HOGENOM" id="CLU_016739_2_2_1"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="82"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="666" mass="72048" checksum="7CAF098CEA7ADDEE" modified="2014-03-19" version="1">MACYARGCAAARPASRPLRTFASARASSSSSTPVQRRQLHPIRLSTYFQPTHKASSSASGDDALASLQLLLRGGYIRSSSSGVFTLLPNALRIVRKLTAIIDDELHAIGASRLAMPTLLPAKLWRQTGRYEIMGSELYKLRDRRDAEYVLGPTHEEEVTRLVAGHVESDRQLPVRVYQVTRKFRDEPRPRMGLLRTKEFLMKDLYSFDKSAADAARAYDDVTAAYTCIFDRIFTGADGRRWVAAEADTGAIGGNKSHEYHVQDAAGEDRLITCSKCGYAANTEKAVSMPDPQHMPISASDVRVLLYACPDLDVHDTPMHALVLPATRELNAVKAAKLSSSLAPATQLLYDSASPQPAQWDWKDRPEGPLLRYSTLAVLADFECASLDPAELNDALATALSTYTSPSASSPPASLAELFPAQFGGDTPVAPALTLVDVRTAQQDDTCSSCKSIASLQETRAIEVGHTFFLGDRYSRALEAGFLPTAATKAAAGGVMSNGRVPFQMGCYGIGVSRILGALAQKAASDFTRATSKAGLLWPRQASPFTAAILVADVRDSNKLEAATRVYDALVSKARTQDLSIHAVLARILGGNAQDDLGWSSDEAHEVVIDDRRAQLGAKLADADLTGYTYRLIIGRHLHSHSPHIEVQHLTPTGLDSVLVPLETLCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG50</accession>
    <name>W3VG50_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DinB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG50"/>
    <dbReference type="HOGENOM" id="CLU_083400_1_0_1"/>
    <dbReference type="OrthoDB" id="5564877at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473:SF1">
        <property type="entry name" value="DINB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26946" checksum="05EF4B19897CDDCD" modified="2014-03-19" version="1">MVRTASTWQEAEENIVSCTAQILNQAIEILRSGAIDDASYTFSSRVIAGSTPGKHFRHVLDHLRILLDSIEAWQARSSSVLRVDYDSRMSSKVAHIETSVAASLREFERTNSRFYRIFEGSKGELYTQPLRLCATTPFVVEMDSTVGRELWFCGLHAIHHYALARVMLVKERGLEGIDDQFGVAPSTLVHREWRRETIRAGPAEDSLQLPATTAQRQRQAGADQRQHSSPRHASLRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG74</accession>
    <name>W3VG74_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG74"/>
    <dbReference type="HOGENOM" id="CLU_264448_0_0_1"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1251" mass="132539" checksum="9C15F62E45D91B96" modified="2014-03-19" version="1">MSGFYSHQKSASTLSFDSNERSFSLSSRPATASMDRPGPSRGFHSNSSSVSLGNSVANPNRNGGAPMHAMMVPGMVVPSTDRPDPNSPFSQWEAYIVKQTHEWSDKRAKAVASPPPAANSPRIVWADQIRKSTPQVQPLAYTKARDRVASPPPQGPPPPNPRGLLRKASFDVFRSMPDGGRTTPSPPSSTRPSISSPIIPKSILTTAPAPVHASPGSLSASAFLDTSMRSLPDPSGVPHNVESHASSIRSLSPLPLSLPTDDFSASLLIGLDKRASTASTSSGRAPGPSDLIAAPLPAIYSPDMTGPPSIADTYSVHSRRSSWASSVDLDPAIICTPPLSHDGWQDQPQPARPTFLAEYGLDQDSDESETECSVYPDEEQVAAPLPSVADEEKQHQQHQEMPPQPVFQRLEADLPFNAYGDDLGGTTRIGPNGSPLPRLEISTLPREKDEVQKARARIMSPRSFRKAFSSKKKGSASGSGSASTGSRASESSPSLPNSSSEDVGKVEVPSEPVTAASPAAEPSQLPSLAKDDMTSWAAAIPAQAPPPTSPQLAEPTSPVPQAPAMEATASSDSYPQLETPSEANLSMPLSPAFSTMTPSISSELSRDNASSTHSFGQNSFGQRRHRIVTPGLTKVASSPTIEAGAAPSLDPHLARAMTRARSSGSVSSHTPSVALSNSSSTRRNSRRSGRSRITDGMPSFANMASTLAVPIADQRRLSNRSLSSEGSIDNHSNASNGSSYAKVGGSSDEGVPALAVSTATAVKGVLRKRSPSETSSLLSPRKEVSFNLPVGEFGAVEERASEEEELLEHEQKQRAHLKLPPMKLQASATSGIAAETAETAALSQDDADIVKFLTTFGRDITSVESLEVLDTVNAGTGEWPKRDDWDSLPAYLLAYTTTLLSAYSDDTATMVYSAERAPKTVRGKASAPVLSTNPLYTAVVRSVLGIASWEQPLVSLGAAGVYGYSWTKGRLGTVILVGMALLLATQGAGANADAGKDLADAYGKIAPVLLGDEATQERVRNLVLRRSPRASLRLSGLLVVLAAAATRVASSVVMGLPGLLLGLAVFVWLPVILHQPSWAPKWLSSVNPLDAVLYDVPTDAQHAICTLRRRAAGGDPLVQRTCSLVLSPTHFDHRVSAHELAHAGDVLDGAFAAQIDGDSGHLCVLASRVVFRALTGRTEQRSTSLAQVLDETSACRITLDVRLEKLVALEKVRGDGLRLKLRGGQTFEIVQVHERDQAFNRILALAPHKWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG76</accession>
    <name>W3VG76_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000041">
        <property type="protein sequence ID" value="ETS59792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_228013_0_0_1"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="2043"/>
            <end position="2508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="959"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1229"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1286"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1552"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1829"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2306"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2533"/>
            <end position="2553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1230"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1291"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1316"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1562"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1829"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1847"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1954"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1988"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2010"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2084"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2306"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2339"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2533"/>
            <end position="2543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2553" mass="271744" checksum="2441046A77555F9A" modified="2014-03-19" version="1">MITQPPRAGPSASSPTSPASRNAASPQQRSPITPGRYRAHASVHQAFPSPSSPRSRRSSIVETVDGASSSNSPSSNWQASIELSLTTRRRLIRKPLPQIPSSHNADSIHPSDTASGLISPATLDAQCQRADSWWPDSLPQKHSAPLSSTSQAANTSANPHTPALDPQQPDNPGLDDQSLQHLLSILHYAALQSEGASASTQEDGTIGRNNVVVSATGTYKRQSPLNGTSASASKGADYHDQYVLDQATLDSLYRALQAAFRHLSQKQVLGALQRTASIRWRAEAQLRNATAAQAAETTASSSRWTRFAWPAAALGKAYKEAQRSILPPLPGQSAFVGFESASQIHMAQDAYTGLYLDPDHRVRKRDVAVRILSNAIWFVRNYGPAAGVETLDASAPATTALDQASSPSDPASQGAAGELMPPSLSSIRRTSENLLKKNAGLPTFLSKSSATTALSGTATPESARSDAAANPEATATSPSTAATPESLSIASSVSSPQVPVVPPSESAPDTASTALPPPETGATSTPDPSTKNNNAGGEKSKAVEHLASLSAAVGAAMRQRAQQATAAAVAHGGAPEDWIDAPPTTTGARRPSLHTFVSRSEAEAAETDALEKAEKDYLAEIGQGCNEWAKMVVCRLCASISVKGDDASGTIRHRRSGTVTARDAAKARTEGADTSVGSSLSTRSDMTAKAAKVSSRSSDDLSPADDTHEAVAWKPDVYEGAELLSHLGEHRPGVSLQDEDQRVRLVGGSFVCRVESEEQRQALFELLELGLYVGMSMLLESSFLTDSDAARPKPVKIPTRTTSAVEPPSRGASLAPPFVRTRSSSQATIDGSQRSVSGSSSTREPHQSDLNADADGQSHGVDLAPSKPAPRKWTKSLWGMLGQHPHDAADAEGEASIARSGMGDGHEAHSHRSALTMHRYHTEDDANTLSSTRKALFKTGEEPKQSIAARKAALFASVSNNSAPPTPQGLRGSASNANGSANKPHRLVGRLINAFARPNADAPQKDAQHPTSAASSLARSRDTDIHPPTSAQSVVATHLSSSRSQAQLIRTRPETIFPVTSPSPAALSTSPELSLLQCYQYQQGPQHRLFPSTAYLTAFYRLQALRFLADQPGEHVTFASPSHGISASGDLLPFVGVQKQASSAWSVISSRSQQPQPTQLAATPIQLLSYELLSGDGSAVGLCREEVAFYQRLSNNRDVPLGQVVEELSIRACALEADRDTMLKVHDSRIASSKQNASSAKDRTGQPVAQRQGINSVYGMPEQRLHFVHGQCRIRIVATVMPPSVCGDESEAPHDTVFEDKVKPKEKGPEVDVASRSPSLQASASRDSDVSAIAAASHTDKEAAKTAFAVAETAVRAAETGASQLLIDQKGSGSTSGIWMWNASAKSGWQGQAVPMSESTYLLSFARYLEAVSYHPALRRAAGLEPVNTKAYGGLSNVQQQLRQGRSEDARSIAEGPNLLRFFRSGRSLVKVQVQPLVVYDLHIEGPCLKTSSDRRRERKQKQAQAEKRRFKQLAEETRLEIQRFFASIKRNTTRLEDVFVSRELDEAGRTIRSKTGAPIPSADAKPAPAVGAAASSSDSTISDQLAQPLTFLTNLRASLRADEFELYEALQRTLFLDGINDIRKAFADRAKSAKNRLAAWTKKHLSKKEQADFGSCVYDEPEYIKAGLRAFPGSCYIIRDDEPLSIIAFSLSSRDFRAEMGTLGDRKHDADGYMGSSNDEHVKQWRSGVVDGGQSAAGAGGSIISTAGSTDTSTTASSAMSLLKDRSMRKVPLSQLDPDTDEVFFDAEPVRAALKRKKRARESSILSMTLRRVGSTISDSRGASYQTLTANSLPASSASSLKGRNDDDDDDDEDDDDEDDGEGRGKNLKITGDGRSRLSSVASGSRLEVGSPARDLDATPSRRTSAARFDNRSPSPSPNRPELRNSGSVSALRRTFELRSQASFSSIPDRKSSIQAGTASTISTTSKETTFQAQVTPISGRPASLATIFSSGQPGLETPNSRTSNFTGASAPRAIPRTAPASRRPSGAAGAADPSAAEIGLSVDDLPSLSDDGSSSSSRSPRKHGAQPSNKSEGVAGADAHSMVSNSTLPGSQAAESPHIKHNLVHGTTKISCVSWFAEEFAALRERWGVEHEFAHSLARCSPWAATGGKSKSAFFKTADERFIAKQLLTVWSVDEKEAFLEFAPAYIRYMMNSAVNACPTLLVKIAGVYSIKIKDTKSGETKLKMNVMLLENLWAGDGGKSIRFDLKGIRDRKVKLSAQQQQDLEQAATQAAAEGQPLVNVPGVTQGAATAAWSAGVQAAASSTVKANSGDSQKAGTSEPAGSKGATSPGSADESSKSAVNGAAAAAESEARPASGSSAVWWDSEWISRYRHRAFVPETQKELFYRALQNDTRFLTASNVMDYSLLLGVMERPIRADDMYPAPARAAGGVANVHEAEGDADEVEDAAERPSFRCRIVDFLGAFTLAKQLESSSKKALKAQDAKANVTILPPSEYASRFLSAMDSYFIGTPSHPRLDARYGFDRMCDDTARAAGSEGSGASAVRQPRLASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG96</accession>
    <name>W3VG96_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG96"/>
    <dbReference type="HOGENOM" id="CLU_1142979_0_0_1"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="243" mass="26886" checksum="A75B86E79E61BA62" modified="2014-03-19" version="1">MVSINHENAEYYFDRDVECVRRFFRKRFRYHSDEFPRFKDVVPEFARKQTKLPKSAPQPQDVEQDAANNAQTGDVRLDLLAKASGFGGSKQDRELEQFMSSLRLSTTQGMIEVADSSPESGDEVDSDERDQDEDSDEEEDESSGEDEEDDEQGSDAELSRKARKSAKASANGVKPSRGAARKALLDGDDSKIAQLVASDRAKATRRAEKHHGKKAHAGKGGRAHAGGKAKTGKARMISDSMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGC5</accession>
    <name>W3VGC5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_06147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGC5"/>
    <dbReference type="HOGENOM" id="CLU_023062_3_0_1"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF14">
        <property type="entry name" value="ARF-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="15"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS59842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="328" mass="33827" checksum="C26200007B89826C" modified="2014-03-19" version="1">MSRVTQSRAQTEANAKILRALVKQPDNKVCVDCKKNDPRWASWNLGCFLCIRCSGIHRSMGTHISKVKSIDLDIWTPEQMESVQKWGNRRCNLYWEAHLKAGHVPADHKIESFIRSKYESRRWAKDGPPPSDPATLDGGAAAPAAAPAAAAAPAASNSAAPPAARAPAIDLLDDPAPAPAPAAASASRPVAAAPAAPAAAPKPAGSSSGLFDLDWHEPSAAAAATSPTSPTGSSGARAKNDIMSLFSAPPPAAARAPAANTTNASAFDMAPPAAAAASNPWSAPSAPAPSNNPLFDTSDVWSSTPAPTAPQSQPPKSDAFADIWGDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGN4</accession>
    <name>W3VGN4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGN4"/>
    <dbReference type="HOGENOM" id="CLU_973595_0_0_1"/>
    <dbReference type="OrthoDB" id="2553347at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30795" checksum="0237CBAFE16E3CB6" modified="2014-03-19" version="1">MGPKPRQTIPRPVAASSSAAVPAVGVGGGTVRVRRWVYKRASLVLLLLLQGGCLVLGFVLLTEPCLNAQYKNSLWDKRNYLSLLARDDVGKERFLAAGVKSLFGTLVIQAWFTARLNAYTQGATHHHQQLVEGLKGDKEKVRVEFQVPSFIRQLEAVSASLLLSLPLTALAIYALLLVGGASLTSHWKESATLATHLALLLLPPIHIAAPNPGFVQKLLAANPSPSFLWPLFYPPLFSIATTLLATATLALDSDSPWQTYPFPLIVAGIAGIAVGNVYTIALILFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGU5</accession>
    <name>W3VGU5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGU5"/>
    <dbReference type="HOGENOM" id="CLU_063290_1_0_1"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="206" mass="21027" checksum="92644810B547E15C" modified="2014-03-19" version="1">MSGFDLNQLGNMAQGFLNNNNNNQNQQQGDNNNNQQQQHQGGNGGFDVGQLAGLAQNFSSGNHDSSLFSQAASFLQNQGGNHNVDEQRLMQDHEDVNNNPGSNSAGQIGNAAVLSAIKSVLGGGGNNNNSGGGFQQKLVSAAMSHAADLYDKKDGEGQAQGNKQDAVNQAAQMAMGLAMKNPAMLAGLIGGGNSGGLGALAGMLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH32</accession>
    <name>W3VH32_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH32"/>
    <dbReference type="HOGENOM" id="CLU_1225224_0_0_1"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="95"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="226" mass="25000" checksum="5155E1BCE42B5A5A" modified="2014-03-19" version="1">MQSIFNRWPGTRDAAPQVFVGVDLLRPAYTVRFRSSNIHHSHQQRRRHLQHRQHRAHAPSSDGNQLCLRRVPLFASSSHSPAPEQQSDAGAMVYIKDWPEFQQRSIKLYRQNPHKARYLVKSRASTCSLTLKVTDDTTTLKYRTRSSAILGRLEIFNKAMMLAMAGSEQPLQEANPEPQPAPAAAAPSQPTAAASATNAVSNGPTSATSQPAAASDKKKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHB0</accession>
    <name>W3VHB0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHB0"/>
    <dbReference type="HOGENOM" id="CLU_022348_1_0_1"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit Rpn7 N-terminal" evidence="10">
        <location>
            <begin position="114"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="394"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="542" mass="59582" checksum="9FDE75B65F2EFB7A" modified="2014-03-19" version="1">MEDIAATTSAQAQASDAFDAEPLPASLTNVELRPDDPFDWEAYTSNYPVSARSQRLVFIATHCPALRKTCSKAAMDLFKQSTRDVSAYQAMATIHNTEAATGNLIPASERIQVDSDWIQSSRQKNSAEREKLELEMRNYQNNLIKESIRMAHRDLGDHFAQSGEWSEALKSYTKIRDYCSTTDHVIEMCLNVIEVSLRLENWTNVQTFVSKAEGVLESYVPSSGAGQRKLSSLSTTSIAPPTKGGSTPGADAIGALFRAGGSSAASTPPSRPRGNTGGESASQVAASKLVAETGAKLRAANAVACIGQGRYEAAAKLLLSIDPAHSSSLLDIISPSDVAIYTALCSLATMQRPALRTQVMESTKFRGFLEHEPYVRDLLEAFSTAQFRKAGAILDEHQARHLLDPYLAPHVGFLRTALTRRALRQFFTPFDRISIARMAEAFGWTHKRMADELVVCIKRREFRNLPGKAAEVGDARIDSINQVLEYRTKDARRAVFDSALELGDQRCRETKRLLLRMKLVENGVVAKGSYSAEAWSQISNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHD6</accession>
    <name>W3VHD6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHD6"/>
    <dbReference type="HOGENOM" id="CLU_009191_1_0_1"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="368"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="817" mass="90039" checksum="4F111ACB08258747" modified="2014-03-19" version="1">MSASQAGPSRTTLHTPASPTAQQSYIDPAAAPLASPQLANRINLVTYKQSTIKALIDPSLPVQDVIRQLCANAHLGVQEPPALFALRDDDNDELIDDANMAKKIEAGANFKLCSSPTIEAADMVDKLGSCDERVLKMATYTLQRLIREAPFTNEFVARGGVRELLNVIRNHSSGNTLAYALTSCQNLMDGFEYGWDIIDADIVAKVVNLLVSQERINVCRPATAILKKLVVSGPQDSPKMGRVLTDGSGAASAAPPPVYRYGFDFVYAEFQREPLFLQTLTNRIGSSDTTLKLYSLSLINSLLRNVSDELFESFTSELEKLNASKAVAWLMDSHRGDELASSILDYQTNVIRTAHRRMRTAVTPTDKRHVHALSYIWLQAKISDVVVPNKNPAQTTLNGASRTAGGATTRYKWRRIGFASESAAKEFGRTGWLGLLCLESFVRSDPDLYAKIILEQINRPEERRCMFARASIEVTSILADHWDIESGSFTASTSYLPFLLSLTKVHNLALRFFLRMWNESGAAASDFSRVSALVRSQVHDALGKQDEVSRTWIDLEDAFLHSEYRTVRDRQIKELEVDEDYNSKASIRNLRGRIYRESYEFVRQQRIQCLLEGAWFRNVVASSAVGAGAMGAKQRRGSTSTVETTNMAMPTISNGATAPTKPWRFYRLAPNKKFLYFCDSSDRVPIRGGLDDLPDRIDLSLVTEISHHGGAATGGGSGGAATGRELVISLLQSPDGCVAEMQALNASQLSEWTDGLNMLRDEGGVVSTRETADLINMLTEIGIKVKMLDLTGEQIELPATVQAPPLPSTTEFFFAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHT0</accession>
    <name>W3VHT0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_05079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHT0"/>
    <dbReference type="HOGENOM" id="CLU_2347606_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="97" mass="10300" checksum="CEC2510B765A660F" modified="2014-03-19" version="1">MQSILTRQRTLFAASAAFVVASISVISARRSASVASRTAAHFSATTTSLSDLSPNECLTVTAALNRPASPCKPILSQELLSNFHTYLQALVSVPHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHU6</accession>
    <name>W3VHU6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHU6"/>
    <dbReference type="HOGENOM" id="CLU_016206_1_0_1"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF6">
        <property type="entry name" value="GB|AAD46013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="870" mass="95900" checksum="86ECA2D455C8E917" modified="2014-03-19" version="1">MPPTAPNPSGDRRDNNAASEKAIGAEGGSAPASRRSPGLRLPMMTKVNRDADEDSSDDSADEFARWQATSGPTTPNISETAAQLRRNLSVTGLQDLAHMPRSQIRKSVGNKVWRPQDEEARIPSDWERLAVHVVRGGLRAGNLAFALRATLMLVLELIKSLRTKKFNRNAFGIALLGPRNFRFAALFAIWASLYKAVHNGLRLMTPMPVKKSRSRAASASGAVTLSIEKAGDNAALDDAGAGSGTATPRSGRSALEGKSPEEKAKEKAKQKRHAFMRDPRSKVWHAYVAGAISALAVLVETPDNRIALAQQLFVRGLEGSYNVSHERGLINIPYGAVITFGIACGQIMWAWLEAPESLPKSYKNWITRASQVSPRVPEIYRSIKFDRKADADFALKWFPDGKVPEPLSLSPLRYPDVAPNAMNRRGIKGKNVRKIVEWMDRTRKGDCGGVVDCALVHPWETSHWRGPIDRFIEVTRWILPVYLTLHFVPAIFLRPGKFLKNPVDATIRSLRGSLRSSSFLGVFVIIFQTLFCAQHSLYNYIQASERLRRIVPQWFSRMLISSWIKWVTGFMTCLSLFVDDSRRRAELAAYVLPKGMESAWSVLRKKSYVPFVPGGEVLLTSAGMSLVMGTYAQNPEHLSGLVRRIVYQETTKAEATKTGCHRSRMWGRRSWGRQDVDLTSSAAKGPAVPFAAVKVPAPPSQVLTFWQPLQSPDSFDEKATQRAHACVEATPKPKSGVDPNAAPKLRIGRSVLLRIAEATETFARAGRIGTDVAMNVADMPGSAYIADEIADVSPSMDEMDDVPGPVQLAAAKGSLEQTLHTSRDIDLGEPIKIARNKARSSEAVFVRRTCIGHGLRDQIDKKLAMGYNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHX4</accession>
    <name>W3VHX4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHX4"/>
    <dbReference type="HOGENOM" id="CLU_1195313_0_0_1"/>
    <dbReference type="OrthoDB" id="10622454at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="232" mass="24674" checksum="75F9811253820E7E" modified="2014-03-19" version="1">MGRSGVGRRVLDLAAAAARAATMQPKAEGGQSLKQAGSGRRRHANASPCLALPRHASPAHVRRLIAASAAANAGKKEPSLALSSPGHGITPRGPAKSNPNSKVELHRPTAAAPTPRPHRWQPQAGAALARRRAFLFVARSSSAQQQELSFIWARASAAAWTRWWGVDRQHTRTPPFKPAATHRSPLLPGSSSGKTASIAQRSARVDRKLRGVRSASASFPWPVVRNKHAIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI52</accession>
    <name>W3VI52_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI52"/>
    <dbReference type="HOGENOM" id="CLU_354195_0_0_1"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="766" mass="83049" checksum="5AD240A2C5F15870" modified="2014-03-19" version="1">MMPSTQDPTAGPSATSPSPPRQFQADANEAARPSHAPRSATMETMVDSHTAQAPAYVEHERHASAAASDAHPTATTQPVGHTSKAHLVELSRPQSHPHHDSEHASLLPQAKGHTPRPSSHTTRAHPEPPHDQHDHHDDAPPSSHDMVLLSAHAASHAPSYSDLFFDLLFAACLNTYSNAVSLEKFGNVAAFLGYFAALWWAWWSQSYFDVRYRRPSHAHPFLFKSAQRIIRAAVLGLWVAFSTTPSEFSRGGFTNFTLIYGCSRMALALDHAVVLVYDLFRWRKHPAHAHAQSAQPEIEPAHAALQTAPRRCAKAAVVRTHLFSIAALIASGLLWILSRLVPRNGVNAPLLVMWILGVTLEAAVQLGNELSGALSPLGDSVLPERLVLFGLIILGEGFTGIAETLNRISPGAKVRNEALGGAAIESGGWGADTILQAVSCVLIVVLQFGGYFHRAANSIDAASVWVVVWAYLHVVLHMSSALLVIGLKKILSFQNTLNAMTNFFAQPTIYLPNTPQWQSLSSEQASEPYNEGGGSSSLSSNGTLAGISAIISVIQSNDGANIPTLSAAQRLVASVVGLAGGEAQAQSLVEQANETDSSNALSSQFAPSLVLPFKSYFEFADNVVNPDSIEQYIVKSLFQFKYIYVASAVYLTVDIVIKLMQDRRDRTLRSFRWAMATRFAFAVLLVLLQVVFTVYEGAPSLAALDGALAICAAVLLAELIAQQIIDALRPRLDRPRTKPSSRSTCSRSDTSSQDHQHFEMHERPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI65</accession>
    <name>W3VI65_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_05351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI65"/>
    <dbReference type="HOGENOM" id="CLU_028692_0_1_1"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS60507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="313" mass="33788" checksum="806D2E9038835286" modified="2014-03-19" version="1">MRNSIVRLGQGLLRQTPIAAPARSFGSVSAPALSSRGRTYVKQQQQPARTGLKDLHPLPESMREQLESDGAPQEPYTASGNSNDPAVHSSRPAAQPAGVDVDPSVAAPGLVNGSSGNGSNGSSSSSATTSAPSSNVSEEWGTSFAGLGERSFSKEAVDVLMGPINESDIEIKPDGLIYLPEIKYRRILNRAFGPGGWGMAPRSETNVGQGIVSREWVLICQGRFVATARGEQEFFKPSGVPTASEGAKSNALMRCCKDLGVSSELWDPRFIRQFRKKHCLEVWAQDTAGKKKKLWRRKDDPPFEYPWKETGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIC9</accession>
    <name>W3VIC9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIC9"/>
    <dbReference type="HOGENOM" id="CLU_112609_0_1_1"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000015">
        <property type="entry name" value="Endothelial differentiation-related factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="193" mass="20517" checksum="22F4213D9E0F9F69" modified="2014-03-19" version="1">MWLVLSGVPLAGGGDGCCDDFTPPSTFPTTYHQPLSYTLFNMSNTDWDSKTVIGRGVRPSGGSGGSSGPTAYERAKQVGAITDLDRKVTAGTNKGHVGTDHQRIAKLDRDNEVAPPPKVAPTVGKTIGQKRQEKGLTQKDLATKINEKPQVIQEYESGKAVPNPQILAKMERALGVKLRGKDIGAPLGGPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIL4</accession>
    <name>W3VIL4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_04369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIL4"/>
    <dbReference type="HOGENOM" id="CLU_2590751_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="80" mass="8789" checksum="6D6EF3F3C76E4C37" modified="2014-03-19" version="1">MLAPIRAFLSSKRRFGPPSPPLHWLHIRQGRSGAPGTVVLKPFGCSVVPRSEEAARPASAGISAYVPRIALLHRRQLIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIV2</accession>
    <name>W3VIV2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04575</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIV2"/>
    <dbReference type="HOGENOM" id="CLU_015718_1_1_1"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS60676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="448" mass="50146" checksum="EB74EE8BE13B2980" modified="2014-03-19" version="1">MREIVHLQTGQCGNQVGTKFWEVLSDEHGIDHNGNYIGTSDDQLARINVYYNEASGNKYVPRAVLVDLEPGTMDSTRSGPLGGLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVIRKEAENCDMLQGFLITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVLPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYNICFKTLKLNAPTYGDLNHLVSLVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFSPLTARGSQSYRAVTIPEITQQAFDSKNMMTACDTRLGRYLTCAAYFRGKVSMKDVEDQMQSFQQKHSTQFVEWIPNNVQTAQCDIPPRGLKMSVTFIGNSTAIQDVFKRISEQFSAMFKRKAFLHWYTGEGMDEMEFTEAESNLQDLIAEYQQYQDASALDEDLEGEYIEEEELVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ90</accession>
    <name>W3VJ90_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ90"/>
    <dbReference type="HOGENOM" id="CLU_045564_0_0_1"/>
    <dbReference type="OrthoDB" id="5325862at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="278" mass="30583" checksum="D7DCFFED5282FA65" modified="2014-03-19" version="1">MTLFSSLKSKASKSDSDSDSDPPPRYSQVVDDDPNESSSSGGFVPTATLQVEAIGYDTNQALTGRTLENISVFRLGSQDAEYVSMRLKKKSNSCALVRASDETPLISTVYRFGPGRHPRMRILDSQSKVSVEEAINDDNVTGEQVEVKSRSIISRAQTFDMSFGKFEWRYGKRKERAAFDADNILILERTDSVALPGGGLSKGGARVAHLIRNDEYRTPGSKKYSGGNGGRLFIDLRTWSDDKHASLETVEAFVVASSILMLKREADRFIDNHIAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ92</accession>
    <name>W3VJ92_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04789</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ92"/>
    <dbReference type="HOGENOM" id="CLU_1171055_0_0_1"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="166"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="166"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00064996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS60872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="237" mass="26772" checksum="41A01933B255339F" modified="2014-03-19" version="1">MQAYAATIRTRHELNKRHKIDESVSVQMDVAFSNDERVLAWMRIVFFGGRDVQPVWSVLVKEAAYLTAARHSPGTGSRLCPRACLRASLRGELDRRAGWRAKTRKLRACSPWTPALRLGRAAPRAQRVSLRVDVPVTKMAKADTKTKSSTSTQKRTTKSKKDPAAPKRPLSAYMFFSQDHRERVKQANPEAGFGDVGRLLGAKWKEMSEAEKKPYNDMATRDKARAEAEKAAYSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJB0</accession>
    <name>W3VJB0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJB0"/>
    <dbReference type="HOGENOM" id="CLU_294764_0_0_1"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1028" mass="111227" checksum="F3A9CA4DCA79BBBB" modified="2014-03-19" version="1">MSGLGEASKKRSSFSMLTRKDLAPSTKQVTEEAELANGRFIPESKRGWKYELPFSQAATASTSKLHHVAQSSASGSTIAAAGTPRRPKTADVSELQKDKSNGPITAASGGPAGARSTPVSPKRRPVPLAAAPFDETSSDSSSGDERNRSSSSEDELQAPHQEALQQAEALRDGVEQQRHHHPDDIVYPESYPWKPSRQDPQMRFINPAHRNPTAKQAFYDTHFGSSSNYRGLLPASGSILSLNSSKADARRQSGEKGTGTGATSAEQGADAQSNGLVSTVMKPFTTASKLITKARRKSVGTNLELPESAAAASTDATVQLGEEKPTRPHAVPLFHAGGDDLAAQRSGFSYGLSMEDAVQVEAVVSRRSSREDLSSPDRLAEELLEPRTQAASSSKLKEAMHSVWGFLPSFDFLASPPPADGSSKGTPSVNLLEAEAIPSVKKDSGAPDYFKNLSGNVVLMGGYRGSVLRDAETNMMMWIPIKVGVGLRRPTLELGLSREAEEHSEELVYSSEMCSHIGRLVDMGKRLEERIASRRHAKVYSWGYDWRLSLGLSSRKLVAFLEQLYEASAGEPSRRRGAKVVAHSMGGLVALHALATCKDPRIFEGLVFASTPFCGTPNILGPFRFGDAALFNDTICSPRATFSFRSSFYLLPTDKRCFEVPVGEPDQDEDALTEEQKRQRFKDVDFLDPHVWDELGLSPCLEPGRRQEILALARKGADNGTEAHPVQSRPEMDSVDPGKLERETSDAIQASAEEKQAPNGIESPDSSEGVEPNGLTMGLVEGFSDGAALTGQAGVAASPDEQAALQPENRQGAPRNDATASESSALAFDSLDYPTQSWAYLERTLGEVRQFWADIECGFDPAKQAAGQYPPLMLMTSGRTPCVRGALVGVDSASRGEDTEMQGWKDDVRAGDYSRMTYAAGDGVITRRSATTLPGRWSTLLTKRSEAETLPHDRFGKGPPFTSKPPGKARLKMDRYRMRFDGEGIVESAHRHVTLLSDVDSVGKCLEAIRRANIVRNRLPLSSTRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJB3</accession>
    <name>W3VJB3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_04105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJB3"/>
    <dbReference type="HOGENOM" id="CLU_001265_46_1_1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000340">
        <property type="entry name" value="MFS transporter, SHS family, lactate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="516" mass="56147" checksum="EADB0306C468283F" modified="2014-03-19" version="1">MVDPTHGLFRLPSKEERRIARNGAPLNPFKLAAMLTPLQGAMFFSGWLAWTVDAWDFFAVSLSVTALEKQFQREPHAITTAITLTLLFRSVGAAIFGIISDRYGRKYPLVVNLLIIAALSLGSGFIQTYTQFLAVRSLFGIGMGGIWGMATATALENMPPEPRGLFSGILQQGYAVGYLLAASVNLTWVHRTGNWRILFFLGSGISAFAALVRLLLPESELFLRQKAQRDASGSTGESKAKVFMRELREMLKTHWLRCIYGILLMTGFNFLSHSSQDLYPTILQQSKLLTSQQASKATIISNCGAISGGFVAGYLSQYLGRRLTIILFVIITGALIPAWILPNSFGALSAGAFFLQFGVQGAWGVVPIYLSEIAPPAFRATYAGLAYQLGNAASSASSQIEATGGDNLKERNPKWFPGAPATVKEFIPAYARVSAILLGTVCAYLLIVVVFGWEFKGAEFEKALPATIPGAGDQDAAELGEKRNTTDAYDEDSIEHVGDQRFQHISSNEAIDEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK08</accession>
    <name>W3VK08_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK08"/>
    <dbReference type="HOGENOM" id="CLU_031567_2_1_1"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="305"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="506" mass="55170" checksum="92EE6D3B73AF5455" modified="2014-03-19" version="1">MTSRVFFLSFDLHPASSGIFRSATHTWHTASGRSPLLLAQIFAAMRPAIFADAVIAASKGSDGHTLAQLFAIGGPVAASVLLEIGDARPHKITVALRKCTGYLASPWEEMCAQHLGSLYAFSLASSLAAYPPTTPDAEGKTRADRLADAFDAYNAAVTAFLRHFATLTPGRWALPLLRILCLNLRWLAVQADEAALDAKEGRTENASQKVAAAVAGEATVARTSSVANKRLEECARQLNKAFTACIADRNADMDESRKWGTYEVVGMVFKTYFRLKSVSLCRNILRALNAAALPPLESFAKSQQVTFRYYVGVLAFLNEEYERAETELSAALAMCHRSATTNQALILTYLIPVKLLQGRLPCEALFKGSVGDKLQAYRPFADALRSGDVKAFDAALARPDIEAWLVKRGTFIAIERAREATLRTLLKHICLALPDKPTRVAIKTIHTATTSDLIGLPYAYQDLEWILATLIYKGYIKGYIAHERGILVLSAKDPFPSLGSVPITTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK30</accession>
    <name>W3VK30_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK30"/>
    <dbReference type="HOGENOM" id="CLU_031401_0_0_1"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="607" mass="66354" checksum="33C8E9A9B993A269" modified="2014-03-19" version="1">MSDLDIDDASLPSDDDVSCSRPALDSSSRPAYGTLSVQAEDEPVSASRVLQDIRNSAGRYHRLCLQHAELGDAKTAKIFQALFEHGPSPGAAKQPKDSNDNDSSTARGCVAADRAWRLSSSLDLPQWNAFRIVELDNNELTSASLPAICTLLERNPMLHTLSLKGNELDGDAAAYIALARVLAASPLRRLGLSSNPISHRALAAFMDSLPPAGTSLECLELSNVLPVEDDASEPGEERMVAAKAVASFIADAARCRSVKTLLLNGNGFGSRGVRTIVAALIGSASSLDLAEDDSEATTEDPFYETVFRARLRRPNRSLEVVELAGNVERGWLPQDPHEQRERLEAVRKRYARVAHHEIDAIVAFLDLRARRARLNEPALSEQEAPMEIVRHMKAVGVHLDEWARDFEEAAEIGAGLTVGNWQALKQSRLEQNAVDGQRCRQAATAVLAAARIVGCTAQRARTVPDGAQQGFHRFLDLPPELRLMVLKKLDTHSVMSARQFACAISFACERTTIGYGELHYDWTRARAASDTASIRTTPSDTLPAQKWSWQQCLQERAAARNWAADRLDASDQSAVLRSRTTGAQMHASVNHPGLYAFLESTMCHRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK40</accession>
    <name>W3VK40_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK40"/>
    <dbReference type="HOGENOM" id="CLU_012062_4_1_1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833264" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS61121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="301" mass="31673" checksum="83EAD43A83528BDD" modified="2014-03-19" version="1">MKVLFNVLVFLIAALGVVFASSSDPVVTHKVYFDIAHDGKDVGRITLGLFGNDVPKTAENFRALATGEKGFGYKGSKFHRVIANFMIQGGDFERGDGRGGYSIYGGKFDDENFKLKHTGPGILSMANAGPNTNGAQFFICTVKTSWLDNRHVVFGKVIDGMDIVKYIENVPKGYGDKPSSDVIVKDAGELPAAGGEEKVVQPSSASPAAAAASPSAAAAKPVVEAASSSGTQGPSVGNNTGSFFFLLLLIAAAAGAYGVWKLGGIERTKTHLTQLVHSTADRMAAAITRTRYNAIPNSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKS5</accession>
    <name>W3VKS5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKS5"/>
    <dbReference type="HOGENOM" id="CLU_058591_2_1_1"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="66"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="296" mass="32746" checksum="BE549FACD846D4E2" modified="2014-03-19" version="1">MQSSRLQPASAASCSERQAAARRHRSRSRRARRHYRLTTNTYLKMASANISKKRKFVADGVFAAELNEFFTRELSEEGYSGCEVRVTHARTEIIIRATHTQEVLGDKGRRIRELTALVQKRFKFPDNSLELYAEKVQNRGLHAVAQCESLRYKLLGGLAVRRAAYGVLRFVMESGAKGCEVVISGKLRAARAKSMKFTDGFMIHSGQPVKDFVDEAVRHVLMKQGVLGIKVKIMQGWDPEGRAGKPFPLPDAVTILEPKEEAPILAPVSESRQAPAEVAAPAQAAPAAEVQAEAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKV1</accession>
    <name>W3VKV1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKV1"/>
    <dbReference type="HOGENOM" id="CLU_748406_0_0_1"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chalcone isomerase" evidence="1">
        <location>
            <begin position="153"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="366" mass="39162" checksum="3B1D9BAAE29926B9" modified="2014-03-19" version="1">MLASNTQLLSRAARLVVPRSVAARKLSTFTPSYPPLPSFSAPGAARPAFFHSSFHPIAASSSAASSRTAQRSARGASTALALLFGFSASVISLSNADTLKLDAAPAAQDKSLTGVAPDASKQLVVDPDTSLGFPLYLPTPASFKSSSAQDQSKLRLVGLGVRTVSFLRVRVYVAALYIDENKLQERLTRASNDKTLEQNVKELLDDGTAAVIRIVPVRNTDFNHLRDGFIRALQNRLKKAIKDARVQTDSPLESEFQLAIHQIKDSFPRGSVPKGSPLDLVILPTAVNSKPVPASLNFEYDGQVFGQVTPNKDEVQQSSANAVDPAFTAARELALAYFADVGEISTPFKNSVQQGFQPQSIPSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL84</accession>
    <name>W3VL84_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL84"/>
    <dbReference type="HOGENOM" id="CLU_009834_5_0_1"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="33279" checksum="D6E6DAFB37D73DDA" modified="2014-03-19" version="1">MTVPTPERSLAGGKVKVYRVGLTAFCTAGVSVPASAQAMVCVIDRASVKNAVDREAASGLHEAFVSFAHDASLCVAILAGAGGTFCAGADLKSIASSSLASATGSEGSNLLDPDMDAMAPMGVTRLAMNKPVIAAISGFAVAGGLELALWADLRIATASASLGVLCRLRGVPLIDGGTVRLPALIGGSRAADLSLTGRLVGAKEAHHMGLVNYIVADNAEASKGWEAVVEKALEVAAGLASVPQTCMLNDRSSMLNALYPASHHEQAGVDLRLKGALRQAMQREFELGLHSLSQLMTEGQVGAFVNRSADEKQQDRSRRTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL85</accession>
    <name>W3VL85_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL85"/>
    <dbReference type="HOGENOM" id="CLU_1886632_0_0_1"/>
    <dbReference type="OrthoDB" id="10611355at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="135" mass="15201" checksum="B83CCCA63FB50A60" modified="2014-03-19" version="1">MEEWTCDDAGAKSKRESQKERIEKKRWRRREVDVWRIKNGDPDARLMQTRRWRRRPSERQRQSANGGSSDLAIQAGRQAGSSSLESGLEADELLHGRFGLASPLPAWTANGCWDEPLCGRSRARVGARRAAGGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLF0</accession>
    <name>W3VLF0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_03115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLF0"/>
    <dbReference type="HOGENOM" id="CLU_119656_0_0_1"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS62488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="154" mass="17728" checksum="547C3893A736315A" modified="2014-03-19" version="1">MFKPTQVACSKASRLPLNSKKANRDFYKGTRTGNIMRRKRIATADPQGNQLYDKNGNERYWHLKTKRIDEARLPNYVVPPGLAQTKLRPYVFAGPASEGGVSRKGKFGLPEYQRMGAEGFDGTYYRSVIGDMLTKRRIKEQQEEDRRLVQNNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLG9</accession>
    <name>W3VLG9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLG9"/>
    <dbReference type="HOGENOM" id="CLU_1256517_0_0_1"/>
    <dbReference type="OrthoDB" id="10412507at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="220" mass="23089" checksum="C3A3093056C530F4" modified="2014-03-19" version="1">MATSGENRAAIIASLCMGRHVLPYRSAARPICADAMDEDKLSASADMAVNKGKEDSNSLSQPDSNVDVASVHAVTIISTTTRRRSGGGGRGGRSQGGGGSRCPPRTPAIPVVAATPHRTASRFMGSASSSEEHARTSSTPLYLPLAAPIWASPNTTPCAQREDRRDQQPSSSSTLVVRLVDARTADLPEPFSRPTACFAGSVHDSRWLSKCGTIQDNIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLH1</accession>
    <name>W3VLH1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLH1"/>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF26">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="2">
        <location>
            <begin position="189"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35974" checksum="A8A3F6176CF821D0" modified="2014-03-19" version="1">MSDSAPVHVLIVGAGAVGCFYASKLHGIHSGRDVRVSLVCRSNYKAIAENGVQLETHSFGNYHFTPYRVFSSIKQAGDYTEGGAFQWDYVVVTTKALPDITNDALDIAPLVTRGVDGSCIVLIQNGVGIEEVHRAEFGQNPIAKPNSLLSDSTLLGQLSSVTDKHIHQLVSWFTANGIRDAEFASELSLQQTRWHKLCINASMNPSSVLSGGTPNARMALDSELRTHLHACMNEIFTTAPKILGIEFDAKKHASPDRILKSTERNTGGKPSMLLDWQAGRPMELEVILGNPIRIARRDGLDMPRLQTLYALLKMAQTRKAEEANPTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLH5</accession>
    <name>W3VLH5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_03445</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLH5"/>
    <dbReference type="HOGENOM" id="CLU_387840_0_0_1"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="14">
        <location>
            <begin position="49"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS62360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="712" mass="76795" checksum="D278DA2A4E311AAF" modified="2014-03-19" version="1">MTIKGLNGEANSAAAAHKPAHFKLENLIRPNILSLEPYRCARDDYQSGILLDANENSLGHSLPPKSVIPHNPGTSNGATPVQSNEADDPLSLNRYPDPGLFGIKDSLAQLRGVPNDAFVFLGVGSDEVLDLVQRVCCRPGKDKILICPPTYGMYSVCAAVNDLEVVKVPLITEGGRFALDVEAVNTKLSEDPDIKITFICSPGNPTGTLIPPTVVKKVLDNPDYKGLVVVDEAYIDFAEEEKAMGKRAQDDVVSAVSLVHEYQNVMVTQTLSKAFGLAAIRLGIAFAQPALVQIMNNTKAPYNISSPTAHLASLALSPQGIAQMRENVQTLIRNRDQLMADLKSVPGTGAILGANEANFVLVQILDLETRSRPDNNVAQTVYKRMAEEMGLVVRNRAKDLGCAGCLRVTVGTEAENKRCIELMKGLLDGSNAKSSNKVAGGQLTKYAFTSSALGSLETQINVFVPSSASSSHKVPVLYYLSGLTCTEDNAAQKGGFFNAAESAQIALVFPDTSPRGAGVDGEDESYDFGTGAGFYLNATKQPWNKCYNMYDYVVDELPKKIASSDLPIDTSRASIFGHSMGGHGALTLYLKNRSAYRSASAFSPICNPTACPWGKKAFEGYLASGLEEGKQYDATLLLDQADGQPDILVDSGTADDFYKQGQLLPENFEKVAKNKGFKNVSVRLQDGYDHSYYFISTFAEDHIKFHAKSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLM0</accession>
    <name>W3VLM0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLM0"/>
    <dbReference type="HOGENOM" id="CLU_111658_4_0_1"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833089" evidence="6">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="145" mass="15207" checksum="33DFACBF7B8E06AB" modified="2014-03-19" version="1">MKFAVIASVLAFAGLAAACTPPSTTNCGGNVYSSDDINTAIQAGLDDAASGDRPDNYPHSYYVEASEGIELCCSSSGPYSEFPLVYNGPYYSSSDNYVSPGPDRVLYATDSGEYCATVTASRCRDTESFGQAVALYELAVLESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLS2</accession>
    <name>W3VLS2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLS2"/>
    <dbReference type="HOGENOM" id="CLU_069856_1_0_1"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="288" mass="30769" checksum="3D2C91F69C022ED4" modified="2014-03-19" version="1">MAFDFGESKPSDPTADFLAREREAAGVLSGDADLFGSSGAAGGAGSADDFERSASAFPALDDDGLPAPTSSNAAPSGGFGFDDIDDRPEPTSTTSAKPVDDEVGKFEQNFPELDDGAATNTNGASYHDDTDDLMSAPAPAASRSAAPAQPSYSYSYEEPTEEAEPVRLWRESQKDAIAKRDAEGERKKAEAISQAEQDIDKFYAEYNAKKEKNIAANKEAEAKLNEQRTRELAEGTTWNRVTKLLELQNSQSKTIARSGPGSSDLTRMKELYLSLRREGETAPGAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLT1</accession>
    <name>W3VLT1_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLT1"/>
    <dbReference type="HOGENOM" id="CLU_488454_0_0_1"/>
    <dbReference type="OrthoDB" id="3362485at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="526" mass="55416" checksum="C270388B71982995" modified="2014-03-19" version="1">MAVPATDSYSPLNTVAVVPYDLPASASSASRSRAALDASARSAGSLVSAASNLIGAIAQGTTSLQTVQSETLSDDAESDDGSSSFTYRAPAGTSSGSQGGGWYASTPYHISNRYYEVDITLKATRSALASASETSSAAEDSVLSQPFPAYLVVVDRSRSLDHHRQLAASLESKVSSGFDADISIVVGVSLLSSSHPQLVQNLDDEPRHASATLRRASNEIAKTSDLVAVYADAGWEFIAIDEADADGSDAQSSRGHGSDGEDSEEGGDGIERIREALMNHMWNGLVRKQEATSALRGSLPEGSHSSVASAPLSSIGFSEDATAWRDNQHDLLEQAPRLDSAVEAASREESSQEGRLPSLGVGTHAETSELDEQLANLFLSSSRPSDLAELEAFLASEDPSWPTASSSSAPVPAAPAFDDDFDDFLPFQSAGSSDAWTAFEGADLPSEREVANMQNVLFGSQTGSADEGDLVSQLNQLQYHAQRVRGIDDPDQRRKQAALVALAFSMQWSDSEPRQAQPDGSDGLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM45</accession>
    <name>W3VM45_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM45"/>
    <dbReference type="HOGENOM" id="CLU_057568_1_0_1"/>
    <dbReference type="OrthoDB" id="1929311at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032704">
        <property type="entry name" value="Cms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14617">
        <property type="entry name" value="CMS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37521" checksum="85177E267DA547FC" modified="2014-03-19" version="1">MADTLEENYLLDEQDAVSVVGSDDGAVSVQDEPVLSNEASEDAAPAPTSTQQESKDEAARKLDKKRKRKEKEKARKQKRAAVSAELVQGVGSVATQPSDLQADYLTSKQSASFAKLSELELEELRLRESMLLDTNAFDKPRTVDTLADFVRKCMPSIAKNIVDSQHPSVSKPGHPALVILTGNALRAADLARGLRSLGPQLPDSDDRSTGPAKKRKMANGSNKAQKDDADAKSGRKDSKALLGGFSVAKLFARHFKLKEHEAWLREHTTPLAAGTPQRVAALIASGSLHLDSLQALVIDQTWVDAKQRNVFDTFETRDELMKLLALDAVMAALKRSASPTKLVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM79</accession>
    <name>W3VM79_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM79"/>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="357" mass="37825" checksum="EE2452AD4021EC3A" modified="2014-03-19" version="1">MASPQQIKTPLTEAFGLKHPIMLAGMNVAAGPELAAAVSNAGGIGVIGGVGYTPKFLRQQVDELKSHLTDKNAPFGVDLLLPKVGGGARKTNTDYTNGQLPELIDIIIESGAKLFVSAVGVPPVEVVKKLHDAKIIVAGIIGHPKHAPKVLEAGVDMVIFQGGEGGGHTGDVPLSIIAPRVVDICRGRKSPLTGKPIITVAAGGIFNGRGLAASLCYGADGVWVGTRFVASKESGAPKAHKEAVLKSTHETDIRTIIFTGRPLRLFKTPYILDWESRPDEIKKLTDKGIIPVYHDLENDDEEGSKEAQARQRFLLGKCASVIDDIKPAKEIVDDMVNEAVAVLRNGNQLLTGQGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMA5</accession>
    <name>W3VMA5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMA5"/>
    <dbReference type="HOGENOM" id="CLU_075836_0_0_1"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="28940" checksum="144FC2BC2E00471D" modified="2014-03-19" version="1">MSSPRHSPPPSAAAPRPKGILKNAGDRRPSQGEALGQDEDAANRLQWDETNLTLHEIEREQQEARMKIDEPKTPFVHGTSIGPVGDDDVFDLDGAAPSSNAGGSRRGSSAAEQLAANTSANAGRNPGEGLGIAVGLDAADLARGASASGEGDVRPVSARSTSRSPSFSLPPKSPSSRRSSSRSATAMADDQRSDVRQQAHDMDLDDGVDGEVEEEDPDPETQAKHAAFAAKRNQHYGNEAEAMKIAAALAAHDDDDDEDEDGVPPLPKAPNGTAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMC2</accession>
    <name>W3VMC2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04061</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMC2"/>
    <dbReference type="HOGENOM" id="CLU_273525_0_0_1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001228">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="172"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="207"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="444"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS61947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1175" mass="127790" checksum="C47F1D8EF0E0A88A" modified="2014-03-19" version="1">MVLAVAAPPSKRRRLDSFHSDSERDDDVDDDDERDDEDNDSESSSRSPSPAAGAHAIAHMISSQRHPSTKTKTTGAIDPSLDDTPSASSPAKHRCDICSKTFARHEHMLRHRASHTDSASFSCEDCGKRFRRSDVLQRHRRLHVTRKELNLDESNTKLTKRQRSALARVEAACLRCSSKKLKCDAAKPSCARCRRLPDTACVYPAHSDTAPSSPTHNVDDAWGNDPPLASFAAHTNSPPIASSTPYPAQASAASPATFAQQPPSLLDTHFSASSISSSTPVDLQPQSLLSGPPANYIPATHSLTHMLHAPPPPVDANAANAQRTLHDLIGWLDGPLVQERPDPEKIDWIFGDSPEAPQLLDWAQMYEWADFDLAARPNALAPSSSDALSALPSFEQAQAQPQNTLTPHHRHVSNATPIQQNSPLFVLSSAAEMLDFGQRSSQALNDSGAAKTPMPPIGVDEPNRSADALPPDNRAVTTGRSRWNSPEPAEDDLVTSDSARSDPSDSKRGSHSADTAAALADRLRPARHAKTSSGRNAAASQAWPNRWNPAIKENSLPSFTFTRASEEHLMAEDMAHVKRIGHGAMHLKNAAEGPLEEERFNAAFASLDAATLNVYLQLFFHHCYSYLPAIHQVTFHPDRCDPRLLAALCAVGAFFSEIPGSRNAAIYLASLDQISVSRATLSNNALARVTSTFQSILLVYMIWRSVGVPSRQEYAEAFRSTYCTMIRRARLLENIAPPKLPARATIDERWTAWIAWESGRRTAWSTLVSETELSVHWNLPEAFAPNEITGKLPCDDRLWEAPTAIEWMQTAKMLAPPLRGLQPGAGDGMPSIVADEADEHFVWPDSSSQLDVATACDIIQRYAQASPNDAVASVTEEEKEALARLSPFSRLCVGSAVMLSTHHTMKMVRFCPMLLGDEEQARERMRNYLGSATDLLSTNQVRDARVDLLLHAIQLFELISPEMLQLLSCRRGVPRMQAARNELNAQLNQAKPWKTRCIVFHAGQMLRLAKQSLQRAPVECLHIFYAAIALQAVSLLVLQNSAGAPSGTIYRIAFNGPARSAVSQGTADAGSTRVWRSGSSASIASSTSPSSAGAYSSAATSINSMDAADARSAPTTFMLESVGNLAHPLAPERILSLASKWLRADDGVGVWPIGQSLAKILDSLAALTPRRTDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMC5</accession>
    <name>W3VMC5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMC5"/>
    <dbReference type="HOGENOM" id="CLU_375970_0_0_1"/>
    <dbReference type="OrthoDB" id="2548929at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="737" mass="81472" checksum="CCBFBDCEE4D15712" modified="2014-03-19" version="1">MGVSAVIRGGFGFLLDRHHDVHVSTNNNINVTPTNALHSFFRRQREAPLPITPVSILKSMLQLDDLQALLWAWTIVAILLLFAFWTNPNEASFRPFLTDLVFRQRLRLLNEDDDAALAQSSSSQHPPAAPRSDSRPHSSLLATASGSSAPFALTFGSKLALSVRTPPFHRKDLGLLSIVTISQSTPISTSTPQPTNADAAIDCTSLFIGAFGKWWVLGFAIPDLPGARSRSPHPTDKPDREELEENITDLADWGVLEMRAIDSESDSHHTLTHPNNTPSAQDPPKNHQPRTTPPVQPPAPVVHPSHPAQKDLVDRDTLENEDCLSITSLVARSRSEVADLHDQLAQVRSASTRACQALEHDLDQVRSKKKEEERLRSDVKTRTKALDDSKRQVESARREAERRLKAANAARALKQASIQQRKEQIESLKKRRANLVARKATNAEKRQQRSDELSQLISQAKSNTDMLRADIQNLQQELDEAHNLLQLEKLNARHAHEHDFSRDAAHLDMHAPYWSPALEQSQLDRQDAIYAQLAATPDPLVDTLARMEERSLAANQYSPSLLDAESAISINKLQTARIDGYADLGTSVLRNAFRRANAAAVADGHETLATAPQGLANPSLQNVSNFEAIKQAFQPTLATEEDGRRSWSAFDVWQSDLRSGGRQRMQWSSGGANASADSLPHFSTSSSFLPLDRSNSAEQGAPSFAGSASPDSSRNLSKVKRAFRWPFRPSQVQDDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMV5</accession>
    <name>W3VMV5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_02663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMV5"/>
    <dbReference type="HOGENOM" id="CLU_009026_1_1_1"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="132"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="321"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS62899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="703" mass="74314" checksum="AEB672A3E77CF99D" modified="2014-03-19" version="1">MSSTSSFRDATDTRKRQSKRDEAIRKKIEGELQRKSGKPATPIASRRTKRSARPPVAAAGTVSALRPLPALTVPQSISVADASQLCAAKRTDCVLVVDEEEHLAGIFTAKDLAFRVVSAGLDARNTPVSTIMTRSPMVTRDTTSATEALNTMVTRGFRHLPVCNEDGDVVGLLDIAKVFYEALEKLERAHGSSQKLYNALEGVQSEWGGSAGPQQAMLQYIEALRQKMSIPDLSSILDSRTLPCCVGVRTTVREAARLMKEHHTTAVCVMESTGTGPGTGQIGGGGAVSGKIAGIFTSKDVVLRVIAAGLDPKTCSVVRVMTPHPDTAPPSLTIQEALRKMHDGRYLNLPVVDVDSRLVGVVDVLKLTYATLEQINSMNDEQAGGDGAAGGPMWNRFWNSFGQSNSIAGDDESAVSGSMRHSESQFEPPTPSKLGAGIADISSDLHPNDSASAVGHALTGDDGASAIGVPSSAAVEADDGTYLFKFVTPSGRTHRFQARYDSYETIREIVCIKLGGDPFFEPVPAAASGAVENGEANGDVQPAVNGAAEVPDPNDFQLAYTDDEEDVVLITADGDVQDAVKVARKQGRDRVVLLLQGGRGWDEAAARAGAAATPTTAASQTARKRQQTRENADAQLQSVAEEEEREAADEEVAPKKTAKRKPADEELLFGVLPKDLALPAAIGFLGVAVLAAVAITKSGSNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMX3</accession>
    <name>W3VMX3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_03681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMX3"/>
    <dbReference type="HOGENOM" id="CLU_034764_1_0_1"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="536" mass="58393" checksum="CFD25DE17A6709AD" modified="2014-03-19" version="1">MASSSINTNGAILAHLAHALARISRIPPRVIASPPTQPRRASVAILVRVRPTPEDEAWLAQHYDPEGQHPVGAPAQPGTADPSASQEMAQSGVHVSQASLGHASMASSVGSVDLSTTLHTFFEQPWVQRGTPEILYIKRAARIGDNWSAHVAFPGGRKEEGDENGLYTAMRETWEEVGIDLAEKEFACVGQLDDREITTSLGKRLLMVLSPYVFVQTSPFSPMPDLQPSEVASAHWIPISLLYTPKPKWGTTSVDISSRLAPKSPLVRWVLRALVGKMDFKCILLPNEPVAVAESDENEDDAHLYADSSMGDKPGVHIARMEEGAVRPELRLWGLTLGMTLDLLSHMTTFQSSSSFRSGGPTTPAAESSTSSPQRDWASRPSVPPLQNTSSSMPSAAELVSSPLASANRVIARVRDEFHLNPPPASHALAPSLTSVFPRFSYPDVNFWIWFFGWRYRSVVRGWESSVGTRIERKFNWSGMALGAFYSAVRRALVVAVILRALGMLSAASITTWLVGRKVNRSRKGLPGLGLDELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMX8</accession>
    <name>W3VMX8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_03687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMX8"/>
    <dbReference type="HOGENOM" id="CLU_009646_3_0_1"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="358"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS62126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="758" mass="82570" checksum="EFAEDFB831D0049B" modified="2014-03-19" version="1">MSTPNNGKGRAIPSPRPTDDSSTPIRSPSRGFVDSPFGHASPTLPNIPPRIGSPSNENMSLYSSSQQQRHDSSAFPSSFQRTISIEPPSRDSASLAPPPADSGISTPSNIENLDALPISDERKARIIERHLARPDANRDSLSATSIQSNDNTDDSVASNDARSAHVNFPESGDVTAESPSEIVLEDVEESYRGPHQMQGGAITDDVYRWAHKNRRVSTRRTRSESLHMPRTATIDPELDVQGIKEPGGFRRFFVINQAEQQGRAPPRALRSFIDFLSLYGHFAGEFLEEDDDDDEDDEDETDDEDDDEDAARAIPGTSRAAGNGDTERSGLLRGRKGLKRSDTQARMRKASKDRRRGEATVTDAVMMLLKSFVGTGVLFLGKAFYNGGLLFSTITLCSVAIISLVSFLLLVKTNLNCPGSFGDMGGILYGPRMRLAILASIVLSQLGFVAAYTVFVAQNMQAFVLAVTQCKTLVPIWALILGQMAVFLPLSLIRRIAKLSTTALIADVFILFGIVYLFQYEIGKVSKEGLADVVMFNSKDFPLFIGTAVFTFEGIGLVIPITESMKEPEKFPRALTGVMAFVMVLFASAGALSYMAFGSAIQTVVITNLPQTSRFVQAMQFLYSIAILLSTPLQLFPALAVLEKGIFTKSGKYNWKVKTEKNLFRFLVVAVCCLAAWAGANDLDKFVSLIGSVACVPLCFIYPPLLHLKGNATRTSTKVLNYAMLFFGIVCVVFAGSQTIRAMVESSAPASPPRCSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN36</accession>
    <name>W3VN36_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_02843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN36"/>
    <dbReference type="HOGENOM" id="CLU_094640_0_0_1"/>
    <dbReference type="OrthoDB" id="9975758at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="240" mass="26671" checksum="2663097A02869618" modified="2014-03-19" version="1">MTETTPSAAASSAFDIDLPFTSYAASHPLHFDSQPSRAIEGFWYIVGSSLPLWKPKKNVVIRYIPSAATSGASDVKFTDEIRSEARSKSASTPVAATELEAKWKAEEGLTNKLFGIKGTNVLQKDAKNGASFQWTGNGLLKFFHSKWQVIGYGPYDLTDTSRTKFDWVVTYFEKTPATPAGIDLYVRDPRDMPKQTYTAIVEYMKALAPQYAADADPKRKQLAQDLAKLAEEFFDIPHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VN75</accession>
    <name>W3VN75_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VN75"/>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_1"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000071">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="154"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="503" mass="54545" checksum="606B6ED7C25CA7C4" modified="2014-03-19" version="1">MSPTAQVVHANPSSHLGDKVGDLNPGSETVPKASRVDPARFLSQASHDRPASAIRALFPAEAIPGMLSLLAGKPNPETFPFESISVNIKPEAESGPTQLTIDGDDLVTALQYGATAGIPKLVQWITQLQVHMHTREVVTPGSKLDGVAGRSPWRVTTGNGSQDLLNKTFDALLNPGDVILVESPVYTGILPSLVMLKARIVPVVSDDQGMMSSRLTEILENWDSNAETAGLPRPKCLYTTPTGANPAGTTASDDRKRQILALARQHDFLILEDDPYYYLHFGGLDEDAVTRKRGKSYWGLEEEHRERWGTGRVVRFESFSKILAAGLRLGFATGPTEILDAVDANTAMSNLQPSGVPGVMAFKLLNHWGIPGFLRHVDSVARYYAKRRDNFEAKARQVLGESGVAQWVTPVAGMFLWLKLNLPSSGPEEPEGDSFALISDKAKAAGVLAVPGVAFIPDGSKTCYVRTSFSIIEEKDVEEAFCRLRDVVLAAWKEAGKPMRPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNC7</accession>
    <name>W3VNC7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNC7"/>
    <dbReference type="HOGENOM" id="CLU_1338286_0_0_1"/>
    <dbReference type="OrthoDB" id="2556641at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="240" mass="24873" checksum="02465785580AA301" modified="2014-03-19" version="1">MDATISGPVVASAVPTISTPEWKRWGCEVDADGQRVAGPGSLPSRHPGALHCPTAIQNLLSGASRRKASAAHGSASGSALSSQSASPWASVPVTPASTPATSDTETDYFAVGSRSRGGASEKKRSSWLGSMPASYWTLQRVPGFEGSSPPTKTYSVRNRQANSRAGSFSSSSSVSDRLPTLAGGENSRASDSSVERSAMALVPNAQFLGLMLLMILLISSPLIKVLSVLLFVVILVLDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNC8</accession>
    <name>W3VNC8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_03340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNC8"/>
    <dbReference type="HOGENOM" id="CLU_003224_2_1_1"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="1013"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="835"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="556"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS62267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120955" checksum="938EE902A2B09E4F" modified="2014-03-19" version="1">MPVSFDQWQHAAVSAIFNVTLDAQQAQESGYEKTYLHELANELAAESGSGTPPQLTAAVADQILIARLSLDPNADVMSDDAQHITVLASLPKGQTSWDYLAACWKKARAEEGRVRKALPAAEQQKALGVLEEIRGLLVSYAGLVLQTPDMFPNAAKPNGTPLSPLVLVDSLMRVSSSMSTFGFSGSDASAHSTTDLTTSFETIDADDLPVFLSELAARFGNGEGLDDILGPAFAELTRRIRDGDRGADPVPQASSSPASQAQSATTQAGGVNPAALNQALASQDVQSVIAQLLAGRIPGAQQGANPLAPNVKPNEGLTIVGLEWRPYVNAIVEAVEIKPIASMLAHLPSFDPANTTASRIELDSLFGPILRLSSFPDAYPSITQHYFANAATQNQQEADSNFRSIQSTMEIVHSLNFRIFNALVRASPQARERVLAYWGRACALNAKRGAMQVRQELVATDGYMVNLYEMLLRFAEPFMDAGLTKIDRIDLEYLRMQTRFDIADLTRINATEAEAKEWAQKAQAGPAPAPANFITEVFYIALRLNNLGLGKAVRRIDDKEKEMGRFKKRIAETEADRAMWSALPQAPQYETFLKRAKAEVDKLHGEIYAAQAQLAAPEFVQRIITFNCFVMTWLIRVAEPNAKHPHPQAALPLPQEVPERFRMLPEHIFEDVCDVMLFVSRISAPLTEQAKNDLVTFCTTFLSSGWYIKNPFLKAKLAEILFYNVIPWGRHTQGVLADTLNIHGLALQHLVPALMNFWIEAENTGSNSQFYEKFNMRYHLSQIFKAVWRNAQHKQQIQRQAQAGSPDFVVFINRLMNDVTYLLDDALDKLQELHTKQSEQGEDGAAGSSTTQERQEREGHIRQLEQTIKSDLQLGTEFLRLLIDFAAETADAFMTPEIVDRLAAMLDYNLDLMAGPKCQNLKVQQPKKVGFEPRNLLRMIMSVYLNLCTKREFVAAIARDGRSYSRPVFEKAGAIAERYMLKSPPELEAWAGMIAQVEERRQMEQDDEEELGDVPDEFLDPLMATVMKDPVLLPRSKTVVDRSTIKAHLLSDATDPFNRSPLKIEDVVPDTELKARIEAFIAERRGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VNS6</accession>
    <name>W3VNS6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VNS6"/>
    <dbReference type="SMR" id="W3VNS6"/>
    <dbReference type="ESTHER" id="canar-LipB">
        <property type="family name" value="Canar_LipB"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029537_3_0_1"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834419" evidence="1">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="342" mass="35518" checksum="4D5BC29047F4DA4A" modified="2014-03-19" version="1">MKLLSLTGVAGVLATCVAATPLVKRLPSGSDPAFSQPKSVLDAGLTCQGASPSSVSKPILLVPGTGTTGPQSFDSNWIPLSAQLGYTPCWISPPPFMLNDTQVNTEYMVNAITTLYAGSGNNKLPVLTWSQGGLVAQWGLTFFPSIRSKVDRLMAFAPDYKGTVLAGPLDALAVSAPSVWQQTTGSALTTALRNAGGLTQIVPTTNLYSATDEIVQPQVSNSPLDSSYLFNGKNVQAQAVCGPLFVIDHAGSLTSQFSYVVGRSALRSTTGQARSADYGITDCNPLPANDLTPEQKVAAAALLAPAAAAIVAGPKQNCEPDLMPYARPFAVGKRTCSGIVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP00</accession>
    <name>W3VP00_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP00"/>
    <dbReference type="HOGENOM" id="CLU_439489_0_0_1"/>
    <dbReference type="OrthoDB" id="4093673at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1230">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF11">
        <property type="entry name" value="RE19971P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="634" mass="68356" checksum="4BAA76602C187B48" modified="2014-03-19" version="1">MAFRQRVLPLLGASAVGVGIGYYVFDPLLQQYAKDTNGTFVAGPPGSNALPDLKPHAGATTDLHERPPLGSDAARGVSGIIARPGTDLKHNDPNQIPGSVPYGTVSKELENLRNNVRNKVDHAEQKLHDAKSDVKSTWRSAKNSAEDAADSAANKAEALKQDAKSSWRSTKSAAEDKADEAAAKAKSGWFTTKDKADEAANEAKSSWFSSKSAAEQKADEAAASAKQGWFTAKDKADEAANQAKSGWFSTKSAAEQKADEAAESAKQGWFTAKDKAAEAGEHAKQGWFSTKSAAEQKADEAADSAKQSWNAAKDKAAEAKEQVKQGWFATKDKAEEVGEHAKQGFFSTKSAAEQKADEAAAQAKSGWFSTKSAAEQKADEAAAHAKSGWFSAKDKAAEAGEQAKQGWFSTKSAAEQKADEAAAQAKSSWFSTKSAAEDKYDHAKNEAQKGWFDLKGKAEDAADEARSNVHSYRDQLEHNAQQKILAAQYNAEVRAGEVQGRLSDDVKQLKGDYKGLKSDLKQTGQEWKSDLDAKARDARNQAESSYQNLRDQSQQGYKNLKDEANSSFYTLKDKADSGYESLKSKTADGLDYAGDKLHQGARKVEGTQKPESTGLWNWIFGNARATEKVASNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP33</accession>
    <name>W3VP33_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01721</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP33"/>
    <dbReference type="HOGENOM" id="CLU_027018_0_2_1"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="33"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="302" mass="32900" checksum="B4C54140A21AA679" modified="2014-03-19" version="1">MSLAPASSSSALHIDFPASAGSGVMHSRSVTGVQVHPVALFSILDHYLRRNDGQHRVIGTLLGTRTESEIEIKNCFAVPHLEDEEEGQVQVDMEYHRNMYELCQKVRPDEVIVGWYATSPELNTYSALIQDFYSRETAPHQAVHLTMDTSIDASKADGLGIKSYISSPLGAAPKPENCVFLPLPTTLLHSTPEHSSLSLLASHNVASPLTDLDALAVSLNQVQAQLDRVLTYVRAVIAGEKEGDKAVGRFLNDTISVVPAGMDDNKLETLFNAHLQDVLMVSYLANVVRAQAEVSSRLTLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP86</accession>
    <name>W3VP86_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_01779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP86"/>
    <dbReference type="HOGENOM" id="CLU_2134606_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS63493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="113" mass="11643" checksum="EC64F07D26CB8955" modified="2014-03-19" version="1">MLRPSPSGFSAVLLFANAPARLRAGSDAQIGKEAHFGKYRTMDGSSQDASPPPISPSTACWVPRVAGCTVDASQHAMLAMLAMHALPASISSISLAPTLIEPARSSASKQVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPJ6</accession>
    <name>W3VPJ6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Replication factor C subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Activator 1 41 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPJ6"/>
    <dbReference type="HOGENOM" id="CLU_042324_1_0_1"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000032">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="61"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS63474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="383" mass="42344" checksum="A26323C8A9A2F9E8" modified="2014-03-19" version="1">MFLQQGTKAHNASQAAQKEKLAKEKAARRPWVEKYRPKTIDEVTAQEHTVAVLKKTLMSNNLPHMLFYGPPGTGKTSTILALARQLFGPELMKTRVLELNASDERGITVVREKIKNFAKLAVTNPKEGFPCPPFKIIILDEADSMTQDAQSALRRIMEQYSRITRFCLVCNYVTRIIEPLASRCSKFRFRSLDTSSTKARLEMIANTEAVTFEDDEVLNTLIGTSDGDLRRAITYLQSASRLHSVAGDDKSAVTSASIVEIAGVVPSRVISSLADAVGIEAYAGSDGDVDMDAGAKKRDAFDHIRHEVRVITREGYSITQLLVQLHDYVIGHPTLLAMIKAKAALLMAEMDKCLTDGADEELQLLNLCLKLQEVVQSDGKAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ98</accession>
    <name>W3VQ98_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PaG_02027</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ98"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_6_1"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="226"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="92"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="307"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="358"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETS63719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="500" mass="54720" checksum="E736D2B123B6FC60" modified="2014-03-19" version="1">MEAQLANLHLDGGADPKQASHPSHGQSHGRGAHPTNAAMRPLAPSSSIASNMGINGGVNMQHFNRIAASAMGGGAAVSSTGLTNANSIVQGMSRGAPSHMQPLNAARPSAQQPTHGHSNLKSRPPSVAGTSAGAAGSYRAPNALSHTSQSTKASNMFEASSSRPPAQNASAASSAPTVDLGRYDGGLERDEARGRRGTMQFDPLVLSSADAGKSHPPTRVWSLNDFEMGRPLGKGKFGRVYMVRTRGGPNKGYIIALKCMYKNELVENKVEKQLRREIEIQMNLRHPHILRLHGYFHDEGRVFLMLEFAGRGELYKLMNKLPDRRFEEKVAASYIAQMADALSYLHSKHVIHRDIKPENLLLGIKGDLKIGDFGWSVHAPGNRRQTLCGTLDYLPPEMVNGEQHDKAVDLWALGVLCFEFLEGVPPFEELENAPAGTYRRINNIDFKIPRHFSPEAADLVRALLKKKPDDRLPLTKVLRHPWIMKYDPDACRRASRGKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQG9</accession>
    <name>W3VQG9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_02811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQG9"/>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS63037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="314" mass="32559" checksum="41230CAB72EA0154" modified="2014-03-19" version="1">MSQRVSQIAGHLSGPAPLLKGQVAIVTGAGQGIGAATAKLFASHGAHVVVSDLDAKKASDVASEIVKAGGSAIPNAGNVMDKDFGERVVKAAVDKWGKLNIIVNNAGFTADKMAHTTDDATFQLMLDCHITAPFRIIRAAAPYFRIKDESKRENMAIVNVSSTSGTHGNDESKRENMAIVNVSSTSGTHGNVGQVNYSAAKAGVLGLTKTMCKEWGPFGVRVNTVAFGWINTRLTQAKEAGASIEIDGKKIALGIPGRPAAGNSKEQAVTAVADIPLRRPGEVEEAAASILFLASPLASYVSGQTLEVTGGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQK4</accession>
    <name>W3VQK4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262639_0_0_1"/>
    <dbReference type="OrthoDB" id="3361157at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1286" mass="136135" checksum="27C5808F8ED9EC59" modified="2014-03-19" version="1">MSIDTPAKRPRNSDASPRSHKRVARKPLSTQQRQSLRHALSLENGIDVAEQLQRLTRGQADLDQIDWSSQNLIATASPSSSLASTSSSASAHVIVRYPVPQSSKHSLRPSHLYPHQPYFSATPIAGPSQPRTPSVRYDDPRHVAFSPCGFYLCAYFPAQPANTPSASLPPSLPPLPSDVQIGQNSGEPMAATASETSIPTINQLSGAHAPLDASLAASTNPSVAHTTAAASLGSASEPSGVFCIWSRAETAALNDWKLVDSIPVDNIQHPAPTAAAGKMDNVLKVNDKGQQILKDGSRASPASKDGVHLHAGVAKVVWLNQRRRVVLSTASSATSHYGGAPFERLSSRGPTCVPAATAPNDEAGPDKDLALVVFGQRGQVTLLCRRNANTNDSSVDTTKARTKFFTTVLQSDLHTPRVQPSPITLDSSTGTERPDGVGSAYASLFAGEAEGAEDGMQYAHDARISHLAVGMPADEPVLLVASKRTSAAAALVDLAEITVDLRADAVTMTTRPLQPISLTPVEPASSDGATAEPAGVPGDDALTLLTWAEVDAKEPSGAAAGKTDSLRLLACWSHLDAASGEDKEDGMGMHSSLAVWDLYKAETELSEAFATLECRKAGQAPAWLDWQLRFASAKTLRGQLITSLVTPRALVGANTAILTSLSAAQGNPGLLSEQLAMVDLHTLELAQRVPVPPRALLRCSRPVVSANGALIAVFAHTHTGATAAIVMWKLPWHSSKPATDDATKPSVDGGSEERARMVQLLALSCVRASDASDISRVYGASAGADDAKLLVDVADVLKITDSKRQDVLVKIEGATAKGPSHDTNSIPFHQALRLLKIRMAIASPASPSVRLQKLVLELGLCYQVLRFARVSTQVTTTAKDDGKKKGKPAGGEMRPRVYYRLESVWPLLAQLQWLLGLLDGVSKLSLATVAAGSQVDGDSTRGEVFEEQFVRMLAKPTPRRLVLHIVAHLVDFVQWVESSERAENLPPPTGASVGDEIGFLANAATRGVLAVSEQMALAREALAHITRSASIDLADFAHLLASMEADSGAAPTARARETDRFWWATLGGGSLGEQGEVKADEGVPTKLLGLLGDAQSGALVDVLPLFIVPTDITDERSVLYDASGDAAHAASPLVEALGAMAAKRDSTRDIMRKTTLRAAVSQSTIINDSATIIRSSAPRTSTEGEVRVDLMRAKRCVRCGALSQDAVHATYAMPAPQPLPNGMVLDATLPANVQMQMQMQMHMHMVQAGLPAPPTMAPLPPPALVGIEALDTRTRNCLCGGTWWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQT3</accession>
    <name>W3VQT3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQT3"/>
    <dbReference type="HOGENOM" id="CLU_589497_0_0_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS63929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="48830" checksum="BB3D63061B99A772" modified="2014-03-19" version="1">MLPSSLPYLRARWYLPTMQNLFASARLASRGLRSARATPHAPHNLAPRLPHAGRPRHFASSSSGPSSSSSSPPPKHGGPSIPHILLASAAIVAVTPKLLEGYAALSGTSPGSSRTSNSIPGKLEPHTHHPLALAASSFYPDAKTSSNHKLLKMALPASVSAGSRGGEDDLAQRLRIRSVYIKEPSLVIERAYTPLYDSLPGTASLAMEGVTRAEKDSLDLLVKRYPDGELGRFLHRAVPDASIPQLEVRGPVDTWSFERDSAPQLPDRIVMLVGGTGVTPAYQLLTNLFGHPNRPASSHAASPRVEVLYAMPDLDNALLVPQLYALANSNPDKVGVSLFAEHLPSTNSATAALGQLQTQSTKRRSWLPFFGSGSSLDAKLQLGTDGASTTIPVFESRITQDHLRRTLAPTAASRTLVLVCGPDGMVTALAGPKSRDGQSQGALGGTLAHLGLKQQDVFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQZ3</accession>
    <name>W3VQZ3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanate hydratase</fullName>
            <shortName evidence="5">Cyanase</shortName>
            <ecNumber evidence="5">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cyn1</name>
        <name evidence="7" type="ORF">PaG_02973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQZ3"/>
    <dbReference type="HOGENOM" id="CLU_103452_1_0_1"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="6">
        <location>
            <begin position="95"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="168" mass="18669" checksum="C5AFCA55355B3899" modified="2014-03-19" version="1">MSSSSSTSSGQIQTPKILSTLPPIYAALHAAKTKSSLTFADLATKVGRDEWYVAAIFYGQAKPDASDVAKLSAALNLPQRYLDEAFGEDYFPHRGLGDFPPQDPVLYRLYEVLVVYGYPLKHLIHEKFGDGIMSAIDFEGHVDKVKGAQGEDRVKITLDGKFLPYRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR44</accession>
    <name>W3VR44_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_03012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS63226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR44"/>
    <dbReference type="HOGENOM" id="CLU_074544_0_0_1"/>
    <dbReference type="OrthoDB" id="3359708at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833496" description="Serine protease" evidence="1">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="29651" checksum="F8CFD3CBD66AFB31" modified="2014-03-19" version="1">MLPTSMKALVVLVAAASSVAGSPVPTKRAPTWADRNTATIHPGVNTNTAGSCTSNFIFYQGSDIYIGQAAHCASTGESTDTDGCTAGSLPEGTQVQITGASKPGTLAYSSWQRMQQRGETDANTCAFNDLALVLIDPADHDKVNPTVPTFGGPNGLRSSGLASLEQVYSYGNSILRGGVTLLSPKYGVNIQDQGDGWSHNVGTVSPGIPGDSGSGFMDKSGNAFGVLSTLQFAPLPASNGVGDLAKELAYAKTFDDFAGIQLATGTTPFAVALPDLSTGLVSTAKALGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR83</accession>
    <name>W3VR83_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR83"/>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="60037" checksum="9978706B9D42A046" modified="2014-03-19" version="1">MVETDIVPRIGDAIVWALEKPSHLLVTVFGAVFLFHLLPFLTNAAVRKYPGPLLAKFTDFWLLRKAMAGHRFQTVHEQHKKYGKFVRIAPNHISIADPDALNPVYGHGTGTLKPAYYDAFVPPRPFPRGLFNTRDRAEHTRKRKIVSHTFAPKTIVAFEPFIRREVQLLLERWDEFCEKAAKSNAEGPRGIKGRAWLDSLLWLNYFAFDTIGALAFGSTFGMLEKGVDEAKVEYEDANGNKQVDYCSAVKIINERGEFSATMGLAPVWMRPYLLKLPWFANRLKSVKKLTGIALARVNDRLQNGSEREDLLAKLQSAKDDRGEPMGKMELTAEALTQLIAGSDTTSNTACAIVYHLCTHPDKMRKLQAELDRELEHAEEVPLHSDVQELPYLQAVLNESLRFHSTSAIGLPRVIPEGGATVCGEHFPAGTVLSVPAYTLHRTQSVFGDDAEEYNPDRWLAPNAKRDFDKAFIPFSVGPRACVGRNVAMMELSVLIAAIFRRYDIVLAEPNKPLETFEGFLRKPVELEIGLKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VR84</accession>
    <name>W3VR84_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-arabinono-1,4-lactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_01578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VR84"/>
    <dbReference type="HOGENOM" id="CLU_003896_4_0_1"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="66"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS63302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="702" mass="77188" checksum="A414670CE462611D" modified="2014-03-19" version="1">MASTSKYTLSSPEAAMATAAAAHRASAQIDAGILQRSTAELEKLVQPVVLPSSSPKTKFQNWGRSFVSTPAKVFAPTTVTHCAAIVELARRQGVKLRAIGRAHSPSDLPFTTGWAMRMEGLNGVVDINHQDYTITALAGTYISDIHEALDSAQPRLAMCNVGSISEQTIAGLISTATHGTGILFPVVSSYVSQLTILCPLPQGTQHLTCSRQQHPELFNATLCGLGATGLITSVTLRVQDAFNLKQYSEELTFDSLFGSKTGFPAVSTESHVNTGASIGRLVSKNQRLPPCPEQYRPSYRSKDAAEIHPIPVSANRDADHMARSDVEDDEETRQAQLALEQVVASAQHVRLMWFPQVKRITMLRANRTTEPVSPSPTLSARVKGALIGHRLTELLLYTSRFNKQWSPVAVRWIHALTHPALPAADAKPATAPQSNRISATTEEAAAELVAQNATNSAAVVNDGARDEHQQQLIRDIGQSFAHGGSVGASTEAEPSLSWLQTTVAAGNFSAFARDSPAPRPLSPGNPVWSEVGRSDRIFNMDCLFPQYTDEWAIPFNRAAAAIRAMREWLDEEEAAADGDRIHFPVEIRFTDADSIWLSHSQGRRTCYIGIVQYRPYNRPVRYRQLFAKFEALMRHYSGRPHWAKAHSCSPTELSQLYPHWNDFLATRQRFDPDEVFVNPYVARHLLGRIGDGVDTRVFKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRF1</accession>
    <name>W3VRF1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">branched-chain-amino-acid transaminase</fullName>
            <ecNumber evidence="3">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="3"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRF1"/>
    <dbReference type="HOGENOM" id="CLU_031922_0_1_1"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="408" mass="43796" checksum="497D3639A6E33645" modified="2014-03-19" version="1">MPAPTTTAVPAPATASAGPSTMAPLNADLLQVTLNESAAAPDFDNLVFGQKFSPHMLIVDWNNKTGWGVPHIKPYGPLSLSPAAPALHYASGLFEGMKAYRSADGSGKIRLFRADKNMERMNRSAARAGLPTFDGDEFIKLIKALVRLDRDYVPHGEGQTLYLRPTLIGTPDTLGMGVPTEAQLFCICSPVGNYYSSGSGSKPVSLLARTDVVRAWPGGTGCYKLAANYAGATQPAMEALKEGYHQVLWLFGPDRQLTEVGAMNLFVVFRDQSADGETTNYEIATAALDDGTILPGVTRDTILSLLRAYQQGQVAIDGLPKPERITVAERKVTMDEIMDKAEKNQIAEVFGSGTAAVVCSVDKIGYEGVDISIPIQADGMGVFMRTMLREVTGRQWGAIASPEWSTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRF4</accession>
    <name>W3VRF4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_01658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRF4"/>
    <dbReference type="HOGENOM" id="CLU_029404_7_1_1"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="125"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS63377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="426" mass="44780" checksum="64F40942E6E6875F" modified="2014-03-19" version="1">MPGRLAHQSLGTVPRAQLLPNNAALRSLSTATCTSVSRRPAASTRASASTFAPTLRTAPLRRTLTTSAPRSSQKPFSFLTAYAFQGKPRHSEDAMQEGDSSSSAAADEPEASASGAAEDGAKRGQIGFPADSEIGRWRDELLRGGEAGEDSLMCTSMGSAGDVAIGVADGVGGWTENGIDPSLFSQALMFYASKAAASAPAGSSSTNGNGAPNRILAEAFEHVLKEPLVVAGSATACILTMDASNGTLHSANLGDSGFVILRQGTGKHGVFHASPPQQLGFNTPLQLAKLPKEWIQEGSISNTPKDAAAWECTLQHGDLIIVGTDGLFDNVDAKIEIPQFAKFIKEKHHASYAARHAGAGKPADSLQEDREFVQVLATNLIEYAKICQNSTTKQSPFEREAARYGIHFPGGKIDDVATVCCLVIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRG2</accession>
    <name>W3VRG2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRG2"/>
    <dbReference type="HOGENOM" id="CLU_029393_5_2_1"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="137"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="460" mass="50797" checksum="CBB80BCD0B1D4138" modified="2014-03-19" version="1">MAAAVAALAARCCRSRQHRFYLGRFSLRIRYHTPPPPSSSSSASAAHITMASFSRNLLRSAGKANALPAYSRNAIPSSSRFVSLTAEASRPAQEVPASKSEKFKVDLNEDSFKGYKFDVPKLEWETSKDELIHLYAEMVKMRRMEMAADQLYKQKLIRGFCHLAIGQEAVAVGMEAGMKPSDKLITAYRCHPFTVQKGGTIKSVIAELFGREAGISKGKGGSMHMFTPTFFGGNGIVGAQVPVGAGIAFAQQYLNTNDATFAMYGDGASNQGQVFEAYNMAKLWDLPCVFVCENNKYGMGTSAERSSMNTQYYTRGDVIPGIQVNAMDVLAVAAATKHASDFTLGGNGPLLMELVTYRYGGHSLSDPGTTYRTRDEIQTMRSSSDPIQGLKTRMLDWGIVEEAELKKIDKAAKEEVDQAVEEAKQSPQPKEETLWTDIYYPGTEPDWMRGRDRTEIHRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRH9</accession>
    <name>W3VRH9_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRH9"/>
    <dbReference type="HOGENOM" id="CLU_534316_0_0_1"/>
    <dbReference type="OrthoDB" id="2554046at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS63391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="510" mass="54095" checksum="2094F7A11BF29426" modified="2014-03-19" version="1">MSSSSLLFSTLTPASPSTSSFTSSSRSRPEYRRSSTFSGASIYSRDSWCSNAESDISVSSTTQGHISHEQKAFEQVVLASIATNAIFGSTSPRKNRSAGMRTSIDSARSWTSSGSSVRSPLTPEAPLSALREDEVTKTPMLATIALPPVDEMPKRRRPQLSRIVSDEVQYIGRSLDVPVSEDGHAERSVCIQRSASTTSSASRNSNRYLRFSQAGGKDDLKLAMDELEQELARTMATLSASNSPASTVSVRSRSKAQRRPHTADKVMAVGSAKAYPTGLAQVAVGSSASMPSRSRFQRESWMSSSSIAHEGEAIFFTNPIRFSASDLTLLAEGAEASRRSSVMSIQDECERPISTASSYSSLALRSALDDAGVPALVFDGRHSGSSTGSSVGSFQDASSRPGSLVVVPPVRTSSKRRPGTARAETAAGGIPRAGLYQLGKASRSTPSLVSRPPHEPLPPLPSLPAGLSQLLASAPAPPPRPTKSLARTPTSSHRNSPVPWTDKALPRIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRP3</accession>
    <name>W3VRP3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRP3"/>
    <dbReference type="HOGENOM" id="CLU_020088_4_2_1"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="648" mass="70204" checksum="D0C25CAB843ECB38" modified="2014-03-19" version="1">MAAYWTNTVRVVRRHAYFVGPGIVASVAYADPGNWATDLQAGSEFGYSLLFIVLLTGIFAVFIQILSCRLGIVTNADLARQCRMLILNEDRHGTPPHQPVSHPKWRRWGLLYPLYAIAEGAIVATELAELTGSAIALNLLFPALPLWAGILVTSVDVILILFIYRPPPNGSFRLLEAIVSVLVFVVLSCFIVLLVRIKPRWPDVFHGYLPSHHVVQSGALYVSVGILGATVMPHAIILGSHFASIDRLPGLDTDEPSFDSPAPQGTPQAPQQVHSTWALVRQSFSRTFSQKSHAKSEVIRLSRVVRSLIQHRTNPHHTDADDGAESLDSVTPRRCGRSRYHDPAQKNLPPRTLDSIRIHLKHASVDIGMSLVSFAIVINSAILIVAAAAFYYTDSRTGPGQVVVASLYDAFYLLKQRLGSLAAVLFAVALLAAGQSASITVTLAGQLVSEGFINWRTDPFIRRLITRLVAVIPSLAVSLAVGKEGLDEMLVASQVALSIALPFVLLPLILVTGNKARMTAKEAPAVSVRSEVASAASSTRSSAQIERPSPRADDIIVGEQDTPASESQALKTPLEPQPELALTNTLPRHPVDAQTQTQQQAHEQTPQAESKAACFANKWYIQAPAFAIFGVIVVADVYVLVTTFGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRQ2</accession>
    <name>W3VRQ2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endosomal t-snare</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRQ2"/>
    <dbReference type="HOGENOM" id="CLU_997939_0_0_1"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="215"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="292" mass="32058" checksum="5F8ED7AB8A4536AB" modified="2014-03-19" version="1">MAQAQPLQGVSIPRYETRTSTASSYTVYAVVVQLPVRSWTVYRRYSEFVRLDKNLAASASSSGEPGGAGKPAPRALPPRERAREWKKTFSGFLSFASGDAAEDDEMWLKQRMHDLELYLKSIVMDADASWRESDAFKSFIEWPMNVKMVTSSPSPRKPTPAAANSTSATRTASMPGALAGTRTLGSAAADAPRQAAQETDTTRPLDNTQLFQSQTDAMDQQDEQLLNLAAILRRQRQMGEAINQELGEQTELLGQLDTEVETTQAKLSKADAKMDRFDGGAAKRKAGIGRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRR7</accession>
    <name>W3VRR7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_01777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRR7"/>
    <dbReference type="HOGENOM" id="CLU_051065_2_0_1"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS63491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="318" mass="35965" checksum="E6E2C2A2CB5377C1" modified="2014-03-19" version="1">MPPRRTRAAVKAESPEPEPEPAAPASPSEPSEPSAGPSNDASASTSKGKSKARAARHQPLVAESAPSPQPEVDEAKVSMADRQARLTALRARMAASTKANRRDILSEQSRARAVAAEMRGPSASRKLQKAEKVLEERDLRESGEDVERHRNMQYSLEDSERWDAKQEQKQKRIDQGQADFGDAAEKAYQRQLRSLKPDVAAYKQQRDADQSARKATGKAVVLGGDEIYYGDHRPSDDALDRVVSHLNKERELIQNRSRRRQDADDDQVNYINDDNKHFNKKLKRFYDKQTQEIRENRAVSDMLALLCGRMVNFKWRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRU7</accession>
    <name>W3VRU7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRU7"/>
    <dbReference type="HOGENOM" id="CLU_478302_0_0_1"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF47">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="63664" checksum="0E093F9A2021CBA9" modified="2014-03-19" version="1">MTSSYARVPTTDPNAPGPSASSSLSSSPLQHAIATLHPHLDNDDQPYELDEKASFLPTHARPTHRQSHHARSHHPGLSWLSPTKREQTHAILTNAAEMVQRTKTYVLLGVCALLALLLLLDRSTASTAPVAATASASVPTSSMSTAAPRLEDDIVLITKVGSATVHSRLLIHLAEQPLSNVYAPNRLYVSDATMRVGEIELYDALANVSDTIRSLDEFSELRAQLSTLHHGNQDLGAMHDKDGGWKLDKYKFLPMLAEAWRRFPHKQWYVVVEADTFVFWNQLVRWLATLDARRQLMLGHPTFCDYDGESTMFTHGGSGFVLSGALVAQSFGKDADFEHHHDELIQKSAFGDALLSKALYDTPGVTLKELSPDGRERFNSDPPRVLKFHRGNWCEPLLTLHHVTPADTAHLYRFARRVDARLGEHDSVRWGDIWDEFLPDFLRVALLRGGEDGDEGGNGVSISGWQAIEDWDSETTDVATASPEQCQSVCATNEGCVLWQWQDTDSKRKRAGAPAKGLCRWTKEFLRIGVTKPDEPAKTTGWMPARVREWQTENACPGHTSLWQQQPSLHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W3VRV5</accession>
    <name>W3VRV5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000007">
        <property type="protein sequence ID" value="ETS64264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VRV5"/>
    <dbReference type="HOGENOM" id="CLU_1540726_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="174" mass="18730" checksum="242935E8555C9D71" modified="2014-03-19" version="1">MRGWANGGAIGPGPLGKPFSASTKSSRVDRYRRRAQKAGGPFLLIGAVTPTPSVHEVQECQRSSHLTEEFSSRTSILHGPPAPPLPKVQTPGSRPLFSTMHPEQEMRFAGLSCLSPWQVRLAAIVTVALTLKLSYSQKRRSHAAKDASQPIVSASHIFPAGGCQVLSNRARRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS09</accession>
    <name>W3VS09_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H3-like centromeric protein CSE4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">CENPA homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_01278</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VS09"/>
    <dbReference type="HOGENOM" id="CLU_078295_3_1_1"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="74"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS64423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="180" mass="20343" checksum="F658528348E39714" modified="2014-03-19" version="1">MARKGYADISYPESAYADTYDERSIASSSEGGGSAMLSRRAPSIQSTVSRRRFEEYSVTEPSISHVGARRRFKPGTVALREIRKYQKSTDLLLRKLPFARLVREIANDFVTSYEHGEYGSGLRWQSSAILALQEATEAFLVHLFEDANLCAIHGKRVTVMKKDFQLARRLRGRWDGLGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VS81</accession>
    <name>W3VS81_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_01252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253303_0_0_1"/>
    <dbReference type="OrthoDB" id="2556774at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1513" mass="160763" checksum="A2618B3A4B113ADB" modified="2014-03-19" version="1">MPRETASRPGPSRTQPSQPSSSRNGDTSTRATAMTNQEVEEEDEHDPSAAARRARRQRRREEQAYKVSGWENLYGGGGRPPVFDIRDLRRSERNAPSNSQSNTSASARHDSHSPRRSSRLPPASAPQPSTSAAPQPRSGKRKATSPPAETRPERRRIRSTSIQQPPPAESDSDDGFEITAWNGPAASQARSQAERTTPVATKLEQSPAKSPQTLPHAHNRDRLFLTSSSSSPARQWSLPPAESAHTAASSRETSLSTSTRAASNKESEDTIVAAFVQGSSLIEQVLRAITRYAESLEQAHRRRETADSLHRQLTALGPTPTLKDIHVITCSVPTRLAKRLAVVFRAWNTHILQRHSNTERTKSPSTAVPSTHAPKPARSSRSASKETSRAPAAAAKDDAAAPSNDIAGTHDSHPPPATIQTSGAQASVQEPSDSTDAQIDQVSASGHPAAVQDEQDPSAHHDLGDTSIGPPASITSAGSPQAYGTPPEDPEEPEEPEEPEETGEPDELGDEVDELEDDDAVPGAGGEQDGAPAQPANAREQSASADQEATELVAEQPSADAAAATPMTTEALPTELPSSERAEEDQASIAGDDPAPTLVRAKEPQTEAAAAKDAEVAADDVVMDATEGKRASPAHSSAEALPAPEERRDGSSTPVPAGPVDAADIETVADLPAAPTADPSRGPAEVQNSTTETASSLSNDAHQVKPIPGVPQAAIPAANATGEAAPLPATTQATDQAEAEPSQDAVASSDSAMATTAAALAMAELPDASAQADADPGDTILDSQSRAQETANGALNAASSVLPPVSEASPADPNPHQEPQRDQEEAAIASGPTADTSAAHPSMAVGSSDLQQPATAPNVVDDDRASVAVSEPDIASGSVLLQELRRLDRAHSQPSSDTSASAPVSSASRPKMTISDRMKSLLKDLGGIKKRRSSYDTMQQLKPLRVGKATPRTIPDLVERWQDPANMIPWTCLEDLYPRIFHPRAETHMHLSMHELMNKVASTRSVQHLAHKIPERVIARALMEFPRIPHMLECWSKEKEGYFASRQLPQPTDTIPEFRFADAEPLQRPTSAASAVDARASAPPSSMLNEAREIKPVPSARDVGGQSPQAVPMSHSHSNPPPHTSGAGQSVNTSALQVPQHNARPSVLQPIAPMPGQSLAPPVGGVRTVAPAPGALSSVAATMLATHARRTLQGPQTSARSAGPGRPVYLLPAPEAQNQSTRTMQPPVVPAQQAQPMHAARPMAGPAFATTGAAMQPGRDMNQFLRQQQQMASQARARQQAATDMRRATEAVFAGLVGDCVSFAEHVLGSRVPSEVAERPYFSEADLTHVVEYVVKVYELEVEAERAAGRRNAAAEEKHAKIMVVKKAAEEVMRTTRILMHVRLCLSETASEALRNASTNAVLRDWQEVLATSPRYVTAVEYLMRFQDVPAGLLTRQERNLMLHTMVVATNKNLERTLEKMVDVDALIGPVRGATSAISEEEAEMIRRECFLIGCICCKHVVGILGQGAKQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VSX7</accession>
    <name>W3VSX7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Proliferation associated SNF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_01079</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000005">
        <property type="protein sequence ID" value="ETS64610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VSX7"/>
    <dbReference type="HOGENOM" id="CLU_000315_17_3_1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001315">
        <property type="entry name" value="SNF2 family helicase/ATPase PasG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="241"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="710"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS64610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="110449" checksum="C0EDC12B1C340219" modified="2014-03-19" version="1">MTASSSKHANGTHDHHEDDDDSHDEELLRAAAQADNQDHHSAPSTSTNSPAPMARSASSQQRGRKPAEPEVDPAVHEQRIDRLKTLLQRSSVYSRLMGEKMEREREARHAAAKKKSAQRAPTTAAEPQPAPTVRKTRSGATATEPAAPAPTTERDARRKDNRKRKAEESLTSYLDENDLETAKQQAEEEQANKKSKSQADADAATDADNPNKDASGRRNQPKLVTGAKMREYQLDGLEWLISLYENGLNGILADEMGLGKTLQTISFLAHLREKGVWGPFLVVAPLSTINNWVLEFERFTPDIPALMYHGNPDERRAMRDKKMRLSKDKDARMRFPIVVTSYELIIRDRKWLANYPWKFIVVDEGHRLKNLNCRLIRELKLFESANRLILSGTPLHNNLAELWSLLNFILPDIFDDLATFEAWFDFSDIHDDQGSNRILSKENTTQVITQLHEILKPFLLRRLKADVETDLPPKKEYLLYAPLTELQKELYNSVVSGEIRRWLLQRKTGLPWPEIQQILDDPDGINTASSSVPTTRVASAAQSRRHSPIAVDDYEPEEEPVVEKRKRGRPRKDAAANLKSSRASTASAYAEDDISASGASTPRHQSARRAKRGVNYQVDELTDNSYFDRLEEELRREPEQLTASQAERQGKLYSIREAQRQIKNMHLENIVMQARKICNHPFLFDWPVDKATGTYVVNKDLINASGKMLMLNRLLDALFERGHKVLIFSQFTTMLDIVEEWANEFKQLRTCRIDGTTPQEERRAQMKSFNEDKGKDACNLFLLSTRAGGLGINLVAADTVIFYDSDWNPQMDLQAQDRVHRIGQTKPVLIFRLVSANTVEQKILKRAGNKRKLEALVIQQGKFRLPAGYQSSLPVGKKKEDQLREIATQLLALESEQVFLVKDENDHIISDDNLEKLLDRSEAAYQRTMGWVSNADDKDAPRKPGRKAVRTAFEVTETNTDEANEQIAKLLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT10</accession>
    <name>W3VT10_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT10"/>
    <dbReference type="HOGENOM" id="CLU_134810_0_1_1"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13526" checksum="D59266BAFD0665ED" modified="2014-03-19" version="1">MAAGLKTIILLSFVLALGFLLIILSCALWSNWLPLLVALIYVLTPLPNSLCARCAGADDFSADYNSGFLDFGNFMTGVMIVSGFALPLSLAHAGVIAPTACWMSIAGGGLVYGTILTYSGFFNESDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VT74</accession>
    <name>W3VT74_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VT74"/>
    <dbReference type="HOGENOM" id="CLU_017633_10_0_1"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="411" mass="44740" checksum="0A07EC9975CE2284" modified="2014-03-19" version="1">MVKETKFYDLLEVSPTASEAELKKAYRKKALKEHPDKGGDPEKFKAITAAYEVLADSDKRDLYDRFGEQGLEGGGMGGGMDPQDLFSQLFGGGGGGFFGGQGGRPRGPRKGKDLVHRVKVSLEELYAGKVTKLALQKHVLCKKCDGRGGKEGAVKTCGGCNGQGIKVVLRQLGPMVQQMQQTCPECQGNGEIINAKDRCKECNGKKINQERKVLEVRIDKGMEDGQHITFKEEADQAPNTIPGDVIIVVDEKPHPRFKRRKNDLYIDVEVDLLTALAGGKILIEHLDDHALSVEIPAGEVIKPGDVKVLRGQGMPSYRHHELGDLYVNLSVAFPDSIDLDAIPLLEKALPPRNALPKTKKEVDVEDVQMDDLDEREARNAKPNGAGGQHMGMDDDDEDGPGGGPQVQCAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTD3</accession>
    <name>W3VTD3_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTD3"/>
    <dbReference type="HOGENOM" id="CLU_006383_4_0_1"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="8">
        <location>
            <begin position="328"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="750"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="559"/>
            <end position="566"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS64809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="787" mass="85430" checksum="89374F3B8C089430" modified="2014-03-19" version="1">MSQKPVDIPAPASGSEAFPTSDAGNAADSAIESGGSSPVMPHAFVHHRHLSGGPGVGPGTASPGRYSATQAQQLALKMAQQEQEQKEAAASAANQQQAPRDLSRSASVRSGTRKLSGGTPGFSSASPRHFSQSSHGQSRPAPFPQASQREAFDVAVASSNLASSSDGLQALLRDHPELVSSSLAAAAGPNLAMTGAYSTRSGSHAGSKSGSVPGTPYEGADHLNQSGHVLAMGGSLSNSFHQAQNQSQQQQHQHGSHSHHHHHHHHAPMSPTHDNGRGRILKDAPEVGEGGPSSGQSGLGAALGLGHGIRTGLSTPNLGAAGARPDYSGAKIVVCMVGLPARGKSYVANRVLKYLRWLEYDVKVFNVGQLRRALARAKYNSSGVKEDHTASFFDPTNPSAYKLRSQMAEECLEQLIGWLKRGGNVGIHDATNSTRARRKEIADRIAKEPDLKLVFLESICTDPKVIDANIAVKVSSGDPDYAGMTPEAAKKDFLERIRHYEDTYEPVNFDGSEAHYSYVKVTDVGKSVTINQIQGYLESRIAFYLMNLHLTPRNIFFSRHGESQYNVEGKIGGDSDLSPRGWMYAKALPQLIKDNIGDAPLTVWHSTLRRTGQTASELPYPKLAWKSLDELDAGVCDAMTYEEIEKYYPEDYANRDDDKFNYRYRGGESYRDVVVRLEPIIMELERQENILIIGHQAIIRCLYAYFHALSQEDLPYIKIPLHTVIQLTPKAYGCDEKRFQLPIEAVDTHRPKPLRSDIDDHPPTPPLDPLEIAATSAPPSQTKPNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTK5</accession>
    <name>W3VTK5_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_00857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTK5"/>
    <dbReference type="HOGENOM" id="CLU_154717_0_0_1"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="95" mass="10272" checksum="0869FF4514967059" modified="2014-03-19" version="1">MSSLEPTPSRVAPRGRDPARGVYYKLAFFSVALFAAPISAYYFAKDRYLDGNATYAGGLAAVVVNIVLAAYIVAAFLEDDSEPKPQPKPDAKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VTX5</accession>
    <name>W3VTX5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_00465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VTX5"/>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006531434" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS65014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="542" mass="59542" checksum="B1C1279B3A1B4CFA" modified="2014-03-19" version="1">MRPTLFASGLVALAATAIRAAQIPFELQSPRAPAARVLDHPHLPAHSLRVVSPRADLCDASVKSYSGYLDVDVDALKHDPSSHPGLDSALSTTRHEKDGRTKGAMEHFYFWAFESRNDPKTDPVVLWLNGGPGCSSFTGLLMELGPCNAVDPATRGGKPGTERNPWAWNNNATVIFLDQPVGVGYSYVDWANQSRTDKPPSRVFSAESAAHDASAFLHLLAMHMGREIFNGDGEIFPSFHIAGESYAGRYIPLLADQILADNKRIAKHPEMGLQPLSLASVLIGNGITSPKHQYPAYVEYTCTKKSGSEHPLLPKKTCDRMYESIPACLTLVEKCNRKDKHGRTYDTLACKAASDYCEGALASPYDTLKKSPYDWQHPAKYDEEDWVAAFLNDADTKHALGVDGKGPGDKHDGVFVGCSDDVYANFGKTGDGARDSSWAVTSILEQGVRVLTYSGRRDFICNYLGNRAWSEHLAWSGKKHFNKQPLQKWFLHDKTQGGEFKNANNLTYAIVDAAGHFVPHDQPQAALAMFNTWLHSDKPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU09</accession>
    <name>W3VU09_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar ATP synthase subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU09"/>
    <dbReference type="HOGENOM" id="CLU_073641_0_0_1"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25531" checksum="0D95EF0B3C763E70" modified="2014-03-19" version="1">MSSRPMNDDEVLSEMKKMVAFIKQEAVEKAREIQIKADEEFAIEKAKIVRQEAINIDSQYDKKIKQAEVSQKIAQSNQTNKSRLKILQTREQHLQSLFDATRDKLDGIAKDQGKYKKLLSQLILQGLLQLMESKVTVTVKSSDVQLAQEAAKQAESDFKSKAGKSTSVTVQEGLSKDCAGGVMLAGFGGKITINNTLDERLRLLEDRMLPEIRLDLFGPNQNRKFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU65</accession>
    <name>W3VU65_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_01189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU65"/>
    <dbReference type="HOGENOM" id="CLU_008065_0_1_1"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="201"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS64342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="487" mass="53070" checksum="EC84BCC2918493B2" modified="2014-03-19" version="1">MSARPQNVGIKAIEIYFPRRRLADLFSPALSAAASECRPASQCISEDELEDFDGVAKGKYTIGFGQKYMACTDDREDINSFALSVVSGLLEKNNIDPRSIGRLDVGTETIIDKSKSVKTVLMDLFAPAGNNDIEGIDSKNACYGGTAALFNAINWVESSSWDGRDAIVVAGDIAIYAEGSARPVGGAGAVAMLIGPDAPLVFEPAHGTHMSNFWDFYKPNLSSEYPEVDGPETIQAYLGCLDKAYDAYRKRAAKLRNGAANGVNGHSDASNLASVKVDDFDYTLFHSPYSKLVQKGFGRLLYNDFVSDPKNDKFASIPAEFAELDRKSTITNKDVEKAFAAYGKELQQSKLEPGMDTVRRCGNMYTASLYGGLVSLLSNIPSQEIQGKRILLYSFGSGAAASMFAIRVNGSTEQLVKAADLKNRLASMKVVPCQTYVEALKTREATHNAVNHKPVGQLENLWPGAYYLENVDHMYRRTYGRIPANAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VU83</accession>
    <name>W3VU83_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000006">
        <property type="protein sequence ID" value="ETS64341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VU83"/>
    <dbReference type="HOGENOM" id="CLU_021795_3_0_1"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000605">
        <property type="entry name" value="Splicing factor U2AF 65 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000676">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="329"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="438"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS64341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="699" mass="77268" checksum="AC01FF18B29677EC" modified="2014-03-19" version="1">MTDSADAFLAGIDREVRGKNEDRHGSSARHRDRDHDRDRDRRDRRSGRDAYEEDRSASSSSRKRRDADDRDEHDRYPHKSHRDDRDRERSDRHEDDDRRRRRREDDYYGGSRGSRDNRDRGYGRDSYSYRRDRDRENRYPARRERSRYDDDDYYRDRGGRGRGGDWRSADARDGSPSMRRSPTPEGTIRISQRPRPKSKWDIPAPGFEGTSALAAKATGLFGIPGQTRLVGMPPVNLGVNGPGVPPGVGLPLPPAHMGGQPIHPHRGGPMHPRQPYPPHQNQQQHPGMYPQDGQQYTQGQPPFAGQYQQGHPASHNQALATADSGRQARRLYVGNITHQANEPSMVAFFNEQMLKLKLGTEPGEPAVSAQVNVDKGYAFVEFRHPDEATNAMSFDGIVFQGQSLKIRRPKDYTGPDVRPPSSIHVPGVISTNVPDSPFKIFVGGLPTYLTDDQVIELLQAFGELRSFNLVKDPATNASKGFAFCEYVDTALTDLACQGLNGMELGDRNLVVQRASVGSEKKAQAIAASGANVGALGVPSSVQQFAGAGGDAGEPTSCMVMLNMVTPEELQDDEEYADIVEDIRDECTKFGTVNDVRVPRPAKESKGAAAHQWKRSQNDEAADADKPSEREGVGRVYVRYAETDQCAQALKAIAGRQFGGRTVICAFLKEDDWPGDEDGGLNADDTAAQASGPAFGATDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUK7</accession>
    <name>W3VUK7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ARP5-Actin-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_00250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUK7"/>
    <dbReference type="HOGENOM" id="CLU_008246_1_0_1"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000122">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS65185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="90995" checksum="DC2249634C410FB1" modified="2014-03-19" version="1">MAPVAVYDDRMPHSSHAASSSSSNPYQPLDHVPVHTAADFPRPKSVPKLAYRSSTYWNSNCPIVIDNGTSELRAGFSLADAADPASVAHQPFVAYDNLVSKVRDRKKNLTMLLVGSDVYADGLSRSSIRSPFDADVVTGWDAMEIVLDYTFSNLGIDTDRVQHPICMTETLCNPAYSRGLMNELMFEAYQVPSVNYGVDCLFSAYQNDVADDALIVSSGRASTVVIPTVAGKGILTNAKRLAWGGAQASDLLLRLVQLKYPGFPARVTPWQAQNMLEELCYVSQDYAADIKGMAMMPASHKSYVPSSWTPMERADVIVQFPFQDALPEQKSEEELRAQEERRKAAGDRLREQTRKMRLEKMMQKENDLKYYQQLREHKGKERKAEYLKRLENDGFDSEPALDKMIAKIEGALKRFRAKELGEDYVEDDKQDEPTFPLVDVPDADLDEEGVKEKRKQRLMKAGYDARLRAKAEKAEEKRLEEEALRRDEDERLNNPRGWSAKMRKQYDDAINRIKERKRMKEMLSDRKSLAAQQRMKNITALASDAPGSGSATPTGSRKRKKGGDEDTFGANDDDWAIYREIQNADDSEEEEDAFTQLSTIESRLLTLDPTFGPDDTYAARLARKNRLTLTFFNGPGGGEEASIAPTDTLKDEGESKTDTDPESIKRQHQLHLNVERIRVPEVLWQPSIAGLDQAGLDEICAHVVHSFDADVRSRMLRNIFCTGRHTGYRGFEQRLYTSIRAIQPSSVEVNVRAARDRRFDAWAGAAKWTTRQQETFRNTAISKQDYEEKGKEWFKEHAFSANWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VUM8</accession>
    <name>W3VUM8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_00272</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VUM8"/>
    <dbReference type="HOGENOM" id="CLU_034866_0_0_1"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="15"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS65205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="423" mass="45066" checksum="9D7B680AE7383732" modified="2014-03-19" version="1">MTNTLDITKREQTINLGAGPSSLPTSVLLEAAQGILDYQGTGMGLTELSHRSKTFQALMDKTEADLRALMSVPDTHAVLFLQGGGTEQFSATALNLLAAHAVHNPDYFATNGNQGPPCDYAVTGSWTAKAVKEAARLGANANVAVDARKVQGAGGKFGSIPPVSEWKLSPVASKPAMLYYCDNETVDGVEYPNPGFPLDQLPEDYRKTVPIVADCSSNILSRPIDVAAHAIVFFGAQKNVGPSGVTVAIVRKDLIVDPDAGVAHGGPRIPTTLVYKNMLDNGSLYNTPSMFAIYASGLVFDDLLRNKGGVAGATERSAQKAALIYGVIEASEGVFLPTVRQASARSRMNVTFRISKPGQNQPDEALEDAFVKRCAEANIVQVKGHRSVGGIRTSLYNAVTIEQTQKLAEVMKTFARDVKEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VV57</accession>
    <name>W3VV57_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_00114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000001">
        <property type="protein sequence ID" value="ETS65380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VV57"/>
    <dbReference type="HOGENOM" id="CLU_007772_0_0_1"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS65380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="866" mass="95643" checksum="CE5AE1F0B4AAF184" modified="2014-03-19" version="1">MQRSGYDPYKDNASSSHRDPDRDREHTMRDPHPANAAAFDRRRPPHMQPSGLAHNHPDYDASHHPPTLSPRQPTAEDGWPVAMNEHTHRQHQHHPPPSRYASEHPSSSALPPTQDHPYRSYNPRDPDARRHQQYSDDRSTRYPSHPSHYDGYDQRDNPAHDGQAHQASYRHSPRYHYSHPYPSQPHHHHDYRSEEPPPSSAHSRHALPSPRNLHRSEPRYSPPSDSAARDAPPHLHRYPPATHQYARRRSDTASLDARTPLDSQNGAAPSSSRAAISSSSSSSHHGASAASSATVSASGTAPGSTSAARKRKKQFKYMLEHDVSEPSKASAAATPDDDHERSGADPADAAEGVPGPAQPHKGSRKKVKKACVFCKRSHMPCEEARPCKRCVKRGISHLCRDAEPAGAAGAASTSATTSSSSAPSHIAAPTPTKRRFGEARNHALSRRNKAVAETETDSDAESITSSAASSLRPRTGSERRTSQPFDMMDVMPGATARDPDIRPSMSISGLLSPAKMELQHRPAKREPVSAKEQEDAWNRSMDARMQSKMKHMLEAGPAAADLSDIFGEMPTSLLMTPAMANLPKAQSLLRPSSAELPASPRSAEVGRLKRSQSMTASSTQEHECEVDEAGFKLPLRPKHLLQEEMATTSALRGGKPSYSYTFGYAKLARWMHTRFSRESCEQVDRSLAVFRPKLMELSRSLPEEELIGVEDNFYQLLAWYQANVLEAVPVPMIVTRRTGEIYAANSHACKLMQLPESIFEGGQICHYQLVTERDCVNMWGKYAQEAARTLSTPPTQNVTLEVDRSLLLFNQPAFDPRTGEMLGDGTCPDGTIAVLRKRVVVTFEAKVSKHGLPFLVTGFIIPIPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVK7</accession>
    <name>W3VVK7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_00755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVK7"/>
    <dbReference type="HOGENOM" id="CLU_2607006_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS64791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="79" mass="8544" checksum="FB59EF4F5C63A407" modified="2014-03-19" version="1">MDLSSSLGMSSSSHPLWELVRFFPAAHTASAGPLELGNPTTPPSTQMWAWARKRIHGLVGLLCFGEACWVHALGTLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVN7</accession>
    <name>W3VVN7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVN7"/>
    <dbReference type="HOGENOM" id="CLU_529109_0_0_1"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS64882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="499" mass="57018" checksum="9A8F07FCA202592A" modified="2014-03-19" version="1">MEKGFAFQTPAFLGTRFRQNHQIRQVKNNSRPHLASHRSLYPNSSHSAPSLGLLTARGLPVGANFARTHLSSHRRRHLRRCYDLVHVCLQRRQLALAARFLRVILAAHEWTTDETWRLALLILSLQPTPDGGSGGSSARMRYLQQLDLEESSVFKATHTTYALVGEYVAAGKLLEAVELLEQRVNTHPYKSQPELHTTLGLLYVFLGLKTLESRGQMTEEGVGLRALDRTTREKARRCFEQAVQVGDAWVRTETHRRQRIYFMHRKHERHDAARLAQTRTRLWGTDPLQADTDDAWPEKEHPDIARVRRRLARAEGREEEEESVQSGSETAGEDESVRSDSASSDDNGDDEPERGRSHTRTPSLPRAPHDEDEEDELDKDEQGTEEGGEAEPRTGPRAWAQTWPEVASTWTVAEPFAVEMARTFLALFPAVAPRPTAEPEPEDDTRLRQILFDDPDVPESVFDSEDEQKPRGKHGKHGKHGKREHRDRTRERKHKRPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVP4</accession>
    <name>W3VVP4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS-type efflux pump MMF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannosylerythritol lipids (MELs) biosynthesis cluster protein MMF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_00799</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000004">
        <property type="protein sequence ID" value="ETS64831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVP4"/>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000484">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="263"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="788"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS64831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="880" mass="95821" checksum="C043E0E1ACEF63F0" modified="2014-03-19" version="1">MQIRTGRQVDLCPYCLLHHHPRLLISAKAEAGSSDHRTPCTLGHCSSPSASSQARTATPRRQIDRSSMYYQAGGQPAQHEDRREQGPEQNSHVPNARRSYGLGLSGAGMDDAESSIARGQPTYESWPGPEPMEPLANSPSTAYFPWGPQPTIHDPKLHPASSQSHLVPSKQPSYASFHPQDDAWEGASVHRAHRDYWESSALQPSTSTFDLGYVEPMHRIQLPATSQFSDAKKRQHDGGVMTKLYEYGLHDEHGKKTVKFWTLILAFAITVTLTALDMTMISTALPSIVEDLPASEIAGGWITSAYLLTVTAFQPMFGGLSCVIGRRWSAVLAVVLFVGGSVMCGFAHSILFLTIGRGLQGLGGGGIQAIGEITVSDITSLRERGFFVGIFGLVFAVSSFVAPVLGGYFSDHDWRWIFWINIPIGALALLMLIPTMNLPIPSMPFKTKVAKMDIAGNVVLLGSVVSILIAVTEGGVTHPWSSMRIWIPMVAGMAGFVLFLLIEFIPNPLCTQPVLPLRLFANRTAFSAFLMTFVHGIATYGAIYALPIYFQAIRDEKPLRSAVSTFPSTAPTAPFAIVAGIAMAITGKYKNLTLIGWSFSAAGFAWMTRFQTGTAEWELVVAQIVAGVGIGILFAITLPPIQASLPVEELETATATYAFCRSFGAIWGIAITTSVLTADVSAKLSTVPGVAELGLTGPTVLGYVENIKNLPEAMREPVRQMYADGLQKGMYAFMPVVIVGFVCCFWIQDVPLPDFMRGDAAEEKQHEKMQDRQSVQQAEQGSFHNYGPAQYQEKHLGGPGSGSESQDTTLVESAGHAQTAQAPLEGLFDIVQHHHHTPQTPEGYASHAFKYDASPDPSNFAWDEKRDEHHILTMPPRAHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VVT4</accession>
    <name>W3VVT4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rim20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_00372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS64937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VVT4"/>
    <dbReference type="HOGENOM" id="CLU_007181_2_1_1"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS64937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="868" mass="95021" checksum="C351B7FB7299F0FD" modified="2014-03-19" version="1">MPKNVLSIPSKRTPSISAPLTAVIRNYIANNYTDTHPDAFTSDIRDFARLRDQISSADLHVSAIDTLLQYHAQLVFFATKFPSNINISFPWSLSFPPSLPSWTSTVSGAMEATTSAEAGPASGIAYTTSDTVAHPDLAFERANLLLALAALAESRSEKESIKRATAWFQNAAGVLQYIIDNLVEPTAHLTPPSADLHPRLLSCLKDLMLAQAQECFWQKAVVDRLKDATIAKLAEKVADFYASALQAVSESTAKDASHKNAHIDTGKLTLPSGWENHLAVKRWHFAAAAQYRKACDDLGANRYGDELGRLHLAEQHVKKALDSAKRGVSDAITSDLKSLQGILQSNIARASRDNDLIYLEAVTPASQLAPIQPAAMVKPVTPVELAQPIAHLRDAPPPAFGKPLFAELVPYGVHLAISIYDDRKDSLLRDELASRRDELDALATSTLQSLNLPGSLQALEQPMGLPPSLLRKHEEVVSQGGLERLQRIAHDVERIAATVRDTLAEALALIEHEEREDESVRASFSSQGWARPPSSQVNTELKSQAAEYHETLIKAAASDDIVRRKLDDWEDLIGVLSGNVDGLEAFVPSSNPMASSGGAGGGRTSEQQVQAVRALRERLEHLDDLLDSRSACVTEAKTLAAADDIRPMVMRDAATLSTSSPASGGEIAAADFEELFDRELAKYTHFKEDLDASERAQVELLEQVKQRNTAFVEARRSDATIQRREKALQNLDAAYIKYRELSSNLIEGLEFYNGLAKILSAYRDSVKEWARTRQVDLHWLIHQMGRSSIEDHQAPQQQPQQQPQQPAIQPPESPQARSNFEADAAPSAPKPRQTRSKARAAANEAAQSNPPPPQWGALPPGAKIQFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWE9</accession>
    <name>W3VWE9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000003">
        <property type="protein sequence ID" value="ETS65101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWE9"/>
    <dbReference type="HOGENOM" id="CLU_284140_0_0_1"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="974"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1172" mass="128880" checksum="3B882EBC136C725D" modified="2014-03-19" version="1">MHQPSSKGSVVSATTTITTTTATCQHGLLSSTEAAYTTMLAVDEPDDRVQPAPPSPPPPQGILALPTELIHTILLDLPPLCIEHFSQTCKLARRHVYGDRNTGDLHLWKRLYLERFDDFPSLWQAQDPEHDEAHEESPAKPAAAASSIMSLVQTRDRAARLFAGDPSNHTSITLNFNAVLSALLSVVDTAVPAANLQPCRNSTWLDNSVLASGQPTWSQWIFPRSIMHSLGEHKAQALAHSSTNAPSSPQALKRRRLSNQQATTPSDSQRKPKDSTDASATPTQATPSTSSARRASSSSSKSATNARPESSRRRSARLLKLIYPEPLHPLVDQGIDIDALAHPLTRLAARIHCLHGIRAWKDSQSQRLTASPQEIAGQRSQDGLANQGAAQASAQSTSSAAGQPETEHAPATPQPASVHASDEAESDDDDQESFDEPPAAILGFRPRMFGPSFGFCNAPDEEDQVRARMRHRVYDSAHYGWSNGFAPLHAWRYNTRQGQQQEEDDRDHDAVTESDLATDPEQQSDEEHVNEYGMRFINRRGGSDDGDDDAWREAFELDDASDDIPDDPIPIEIEMSEDEQDTRTFRVADRYGNPIPSDTAAATPNASAARGWGDSDDEEPAATRDDNGESSAAPAPAPYQTPELGSYDADTRTYTYEGHQPIGIVTGSQNIQVTVGDSVDFVASGELNVRFVRPGMLAETMRVTSGHAARRTVTNGIDGDEDEDMDDDYDEDAEEWDEDVDEDDEDDEEEDGRFGPFFDMFRPLDGAWDYRGSYAADELQPLVAKWKAEHQAEGEKPADKDGDANDGDAAASQIVSLRRKSIHWELVEAIMVVMYANLKEAIWLENWGVGIRIPKVYDHAGVLVRDPMERREFLEFPTGWVSSLAAAVAQKRDAEDAVEESSRGVKAEGPAQGQATSNADDDKPHDWARCESFWAGTYAFLDYSHFVEFNVRMARRRRDQLAAASNAAGTDGKASSPSNAAGAPNGSNGQRAASTRVPNLVGQEEAVGDCLQLRLELLPKSEQPAYRLDEEGQEDDAEYPTLYFRGTTVTYWGNDAPMPRGGVHGKVRPVYARDEDADATVTRGKRKIEGLHWSLTHVYDGEDRWQLEGIQPGPPGTRAPMFGVWSDAAHEAESPNGPFVYWMMDERPWKEIERLNRKEAQMAAAARTARTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VWV8</accession>
    <name>W3VWV8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_00314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000002">
        <property type="protein sequence ID" value="ETS65241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VWV8"/>
    <dbReference type="HOGENOM" id="CLU_398021_0_0_1"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS65241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="73578" checksum="342ED3F08F5C0A40" modified="2014-03-19" version="1">MVYVAPLPSALPLPDGLRKDLPRDAAYFGKENWPRTHKQSKHAATNKQQADSIVAPVTHALSAASESDAEVEQATAAAATSKPSSDDADLKSSTSVSDWCAQMVCYIWFSGIDSHEPSFSASSAVSSPTTRPGRLSVTNSPTAKRHSKKLSLGSLSEAVSFSVRDLHNAVEAHARSAVDAGSRSRPTASERSSDPRTLRLFPRRRFTDFVRNMLNTTQVSKSVIILALLYIHRLKSKNPGLRGQDGSEFRLFVTALMLANKFLDDHTYTNKTWSELSGLKLKDVTKMEIEFWLGLSSNIHASDADFRSWIGTLEILAERRHLALCAHEAEKARQTALHQHGLIHSTASKSHPSALLHPHQAPGLSAIYDAPRRIANNSRVSQSRSWSPEVAEPRHRSSPSAATSHLSHMYAAAAAPAPVAALVPRFEMDAGVQAIMNHAGYLTPAASSADCASRSLHVMPNGVQQPLASVCGGAKRSYSQYDQTSPLSEPSCYQTPSPERSTKRRQLDDERAMHTFGAAARNYGLSPPFAQPYPRSVFEPLVSTPNTLLAPFVMQQPAGAAGGMTCKPHPLAYWQLAAGYDRGILGVHMPAPIACQSDYFHWQPAHDAAEVMAIRKPLATTTPYPTPPIDAFSPLYAGYASKQAMMHGYAQYAVQAPHAPFNNAEAHYVDPLLIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VD93</accession>
    <name>W3VD93_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mandelate racemase muconate lactonizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_06542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VD93"/>
    <dbReference type="HOGENOM" id="CLU_030273_2_0_1"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="228"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS59618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="501" mass="55030" checksum="2D3513EE976285A5" modified="2014-03-19" version="1">MTQSSPLIVSSYSIHDVRFPTSLTGDGTDAMNKTCDYSAAYLILYTSPKDSAEIVSYRGRESEAINAPVKEDSSLRGFGMTFTIGKGNEICCQAIASVVEELLLGREIEPLFANMGETWQLMVSDPQLRWIGPEKGVIHLATAAVINAIWDLYARSRSKPLWKLIVDMSPEELVRCIPFRYITDAITPAEALQILQDASKGKAAREAEMVANGYKAYTTSAGWSGYDDAKVARLTRSALEQGFNHFKLKVGADVEDDIRRLSLMRSIVDDPKEMPAGRAEPSAASLEGKNAGPTGCVVMVDANQVWDVQEAIDYMEKLAHLRPWFIEEPTAPDDVLGHAAIRRGIKHLGIGVATGEHAHNRMTFKQLLQADAIDVVQIDSCRLAGVNEILAVMLMAKKFGKIVCPHAGGVGLCEYVVHLSLIDYICISATNERNVLEWVDHLHEHFIYPVSINGAGCYNTPMDPQGGYSIEMLKTSIEDYSFPNGSYWKTGQARTAPPSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDH4</accession>
    <name>W3VDH4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Muconate cycloisomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDH4"/>
    <dbReference type="HOGENOM" id="CLU_052062_0_0_1"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="50876" checksum="BF96E6959B2EF863" modified="2014-03-19" version="1">MALLAVGTFNTNELFTIRFDHETESLELLDVSQAKGNHSWLSTATIPKADDGAARPTHLYATCWTEPPSVAAYRIHRQGSSKASFELLNTAETAARSGYVYVGFPEKATHPVLYTCGGPTGEVVAIDGDTGAFDLTGSKHPAVVPSEAPQDGVTGIGSAGRIQEIDFVTGECSIPGKTLAETKELRRQEAQKASGGGSGSSATAQLDTSNGKNAMDFGGLRHGSHGIDLSPDGTLCYVPDIGRNCVWTMHVDPTNGALSLADKSIAPRKNDGPRHTISHPGGRYIYSLQEHSSMVDVFEVIKDSDGTRLEWRQGVKIIPQSDDEGLYWADEVRLSCAYDRPDGEYPLYMFASTRGLSAETKGWVAVFQLDKDGLVVPQSRDENDELGDALCLWQSPTSGGWANAIEPAPTFLRGPNGTSQYAALTCSEVGVVRMLRLDVPNPQKPNLASIHEVATLAIGKDDNGKLRGAATAVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VDM7</accession>
    <name>W3VDM7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_06576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000042">
        <property type="protein sequence ID" value="ETS59649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VDM7"/>
    <dbReference type="HOGENOM" id="CLU_141719_0_0_1"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS59649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="105" mass="12168" checksum="303D7435965FE58E" modified="2014-03-19" version="1">MFGAFRPSMPSLGGLLWKNPWRLSSPRKNRVRMRLRAVDDVIATLQQSNIQCASLNRALAIPTESQMLPKDKYTTFSKHDRGFRKSVHKVPKWTRKTIRENPVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEB4</accession>
    <name>W3VEB4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEB4"/>
    <dbReference type="HOGENOM" id="CLU_523892_0_0_1"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS59889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="520" mass="55654" checksum="1AE1E15BDA02160F" modified="2014-03-19" version="1">MRSSSTAGLTSQQLLERRRAQNKLAQRRFREKARLARAMGSASALGSDSCSSSGMGFGLNPGFGSTRHLALPAHLDLSSASSHDDLQARGRSASAGSACSSSSASQSSQMSSPTSSCAELLTPVMPTFIELAKPRAAKAHTDVEASALMDRDLKAEQDWAPIASLYTDSYASFNPSQHIPTPIMAAPAPMTFSTLVCPSGVSCNVGLKMVGIHSDPLLLNQALPSPSVLPPPSASHSMPSSTMFMNFEPMAPVESIASFDYLLRLPSTPSSASDSSEAASYPSTDSRSSVPFDEAISEHVARAEPQLSQPTRSVAITSLSFASVAQAIASRFGLAHSGDGLRGLLSRLELFSKSGSADLEPAKGLVFDAGIDWDSLSSNMLPTTEQLLYPHRAFLDACLPWPAVRSRLVKHALAQPVCEEELALDLLLSILSTDEGVASFHVYGDDVLDPEAWELSERMLQKWWGLFDASILRRTNWWRRQRGLTELSMPAPTNSSNAFERQGLGTGSLDQAHRLASTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEC2</accession>
    <name>W3VEC2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI-anchored wall transfer protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_06175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000040">
        <property type="protein sequence ID" value="ETS59860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEC2"/>
    <dbReference type="HOGENOM" id="CLU_020802_1_0_1"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS59860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="765" mass="82582" checksum="DA0D73B2AD88AF72" modified="2014-03-19" version="1">MDRGATSSDDPLAAVDALHRHHNLNHNQHGKAHDPPDPSHLTSHIAAAAEAASYKDLKQAWIADQTGSSVHLVNALALTVLATYAAWALLRAKRIRFVGALHRRRPNELSNVVLAHVFAAAARLSDWQLEFVILIVPVVAAHTVLASQLSLTIGALLVLLVVLERTGPPSARADRPAQNSARKQHWSKKYMDDDEDGRQDDDASAYREPAGPAGAAAPRRPSDALVAEAELPFRVSIDSAADAAHAAAAPPNFYDGPGSSSAALRSNADLSIDTSISTAPRSPLLGSAGSTFASRSPDSALLSPEMASISAFPSPTPRAADNANRTASMQLLHSRDGSDAQSAVSASSAMSPLARSVVDPWSKSKPPSLDHSASATHSDSTSSPGPTGSTASAPSDRSAFVQPQPFLTVYRAHMMLVTVISILAVDFPAFPRAMAKCESWGTSWMDMGVGSFVFSLGIVSALPMLKSARNRFRPWRQQLAADVRKSVPLVLLGSVRVIMVKGVAYPEHVSEYGVHWNFFFTLALLPFAATLSRPVARHARYSVIGLVLTVVHQVLLKTTDWQQWAVSDTVPRDTLVAQNKEGLTSMPGYLAIFYLGLDLGHYVLPLDPYFAYRKLRRRRARPRTDKLAMVLASLSIVWWMAYAAACAVRLGTSRRLANLPYVLWVVAFNTSFLLGYVLVYLFILQPVEGTPGGGGDPVTPRILDDINRHSLVVFLVANLLTGVVNMATQTMYARDAVAVLILLVYTGACCAFARLLTARRFRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W3VEG8</accession>
    <name>W3VEG8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Secretory carrier-associated membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_06030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VEG8"/>
    <dbReference type="HOGENOM" id="CLU_066546_2_0_1"/>
    <dbReference type="OrthoDB" id="242866at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF90">
        <property type="entry name" value="SECRETORY CARRIER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32312" checksum="C34358A2EDFBBEDD" modified="2014-03-19" version="1">MASDPFADRNALDANPFADPSVQGALNDSSRMYAGGDDEAASTYKQASVQDELPTTRADANRMDELRRREEELARRERELESRAAHIQKHGRNNWPFFYPLIYHDIDAEIPPDSQPIMHNLYKLWLLLVATLVVNMVACIFLLIQGASDGGKDMISGIVYLPVITVTSFLLWYRPIYNGLMKEHSLFFYVYFIFAGFHLAFSVYVFLGIPSTGSAGLINTIQAFAGGRLVAGILGCIATAGFGLQGLGNLWYYRLIWKHNNEQGHSFAQAKNELATHGMKAYFTRGSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF16</accession>
    <name>W3VF16_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase yakc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_06124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF16"/>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF7">
        <property type="entry name" value="REDUCTASE (YAKC), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="328" mass="36170" checksum="E5D16F677C129FD0" modified="2014-03-19" version="1">MVHHLKFSDLQVPSPGFGAMGLNFGLGSNLTLEQAEPVLLKAIELGCTFWDTAVVYSAGINEQLLGEFLRKHKVRDQVFIASKCGINCFDGKSGVDNSPAHIASYMEGTIQRLGFTPDLYYLHRIDPNTPLEQSIPALDKLRQTGKTKYIGLSECSAGTLRKANSIARIDAVQAEYSAFETLHETDGLIDTARELDIAYVAYSPLGHGWLVDDFKYASPDDFAPDDFRRTVPKFQGENFFKNKAIVVKIQELAKKKGCTTPQVALAWVARQGFIAIPGTTRAERLVENFSSRDVELSGEESAELRRIIDDAKPHGNRYSAAAQAMVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VF26</accession>
    <name>W3VF26_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VF26"/>
    <dbReference type="HOGENOM" id="CLU_008831_10_2_1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000014">
        <property type="entry name" value="Mitochondrial NADH kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="490" mass="52901" checksum="E51A09C42D93A301" modified="2014-03-19" version="1">MAPPIPLRLAASRIAAFGSVVSRSSVPSRLPSGSAASRTAFHPSTSSTDRRNHGSIASLPPRHFSSSSSARAADRQRDANRPKLQGLPDKVDVCIGPAGRLSKVIAPRRGSKITTRVGSSYAGTHTFSWIEPPSNVLIVKKARDTRATKAMAHIIRHMRATYPHVNIILESEVVDSDDGQLASTYPELVSAHPSEKAALAAKTDFVITLGGDGSILHVSSLFDRDAVPPVLSFSMGTLGFLLPYDIKGYKQALTDMMNGDISLLLRMRLRQTSHRKDGQTFCQIQDQMDGGGCYDVHLMNEVTLHRGREPHMTKIDAFVDGQHLTQAISDGLIIATPTGSTAYSLSAGGPIVHPSVQSLVLTPICPRSLSFRTVLLPSDSVIQLKISDDSRSPAELTVDGRVSKLLQPGEYLQVSMSPFPIPCVSRKWSDRHAHPPGVGDSIPEPVAMGEKYSDRGEDDWVRDINTLLKFNASFGGRGTLSGNGGFEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W3VG13</accession>
    <name>W3VG13_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 93 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000033">
        <property type="protein sequence ID" value="ETS60455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VG13"/>
    <dbReference type="HOGENOM" id="CLU_036301_0_1_1"/>
    <dbReference type="OrthoDB" id="2130735at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833021" evidence="1">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="383" mass="41537" checksum="EA8D75810E4EB219" modified="2014-03-19" version="1">MRFFAKALGLVSLALSIANASPLQKRDFGPVTVYTPGSNYTSDRSLYGRSLMLTVNDNSGTLLTTWENYSGGKTWFPIYRSTDHGFTWSPFSTVTDQVNGWGLRYQPFLYELKQSFAGYPAGSILLAGNSIPADLSKTQLDLYISTDKGKTWKFLSHIAAGGVALPNNGETPVWEPFLLVNNGQLICYYSDQRDPKYGQKLVHQTTTDLKNWGPIVNDVLAPAYASRPGMPVVDKMGNGNYIMTYEYGGAPEGDFSVYYKISNDPFSWADKPIQVLKANDGTVPRGSPYVMWTPIGSSSGATANGTVVVSANSETDLFINRANGAPNAWKRLSVPNAPAAYSRSVTKGFNPKDIVIVGGGLLGQGSTNRVTFSARDVNGCSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGP5</accession>
    <name>W3VGP5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PaG_04731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGP5"/>
    <dbReference type="HOGENOM" id="CLU_011405_3_0_1"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="8">
        <location>
            <begin position="506"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="7">
        <location>
            <begin position="698"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETS60818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="999" mass="109211" checksum="328D432A0FA76065" modified="2014-03-19" version="1">MASTGAVSARRRAQAICLRRELFHAATLSGVCNVRPYKTKRSSGLCTFNLLSNCDFKASIFVALICVLVCTFAPQLFLDPCSQAESATLDKIPLLTKMAPSVSDVRPSATSAPVSKLAQTTPDDKTTEDPRDDNLRRAIASHTFGGAANLRDVFTNQEGRQQRCARLLLLELVAGPVIRCSFGMPALGELLIPRAVMRLHLAASRRPDFSAGDDRKQRCRCSARSLDFPPTPTLPRLHAFFVGMLGRGKNWAVGLIGSRLVHSPVNTTFDTAFFKAPGMALAQSYSCPASQKDFALARPQAACREQPFAPTVGSWLGGGPNKGALFEVISPFFVEPLDKVRGSPDSAHIWDVPASSSALPACVLLSTHLLVVHRMISSPSRSLSRGLRRAAAQCSHAEARAGPSVSRPTASTSSRSTSPRRSSSASAVSFSTSLSRSDRLADHRIISDPFPNQDTGFSYEKRDQLGLRGLLPPAKQSLNTQVLRVLHQLRSKSTPLEKHVMLASLRQTNTRLYYATILANKEEILPLIYTPTVGEACQKFSHIYRRPEGLSISLEDKGKIANIVENWPVPAGAPRIAVVTDGSRILGLGDLGWNGQGISIGKLSLYVAGAGIHPRATLPIVVDLGTNNKKMLEDPLYLGLRRERASTEEYIEFMDEVMDALHTKYPNLIIQFEDFTSENAFRFLERYQDKYPMFNDDIQGTGSVILAGFTNAARIASKESGRPLHDHRILMAGAGSAAVGVGKQLMSFFTRQGLSEDEARSRIYITDSKGLVTADRGDKLPEHKVFFARDDNAGRQIKDLAEIIDYVKPTAILGLSTVKGTFDETVIRKMATLNKRPIIFPLSNPTDNSECTFEEAVKFTEGRVLFAAGSPFPEIEAGQSPTGKRMIPGQGNNFLVFPGIGLCAALCKASRVTNEMITESALALSDALNDEERAEGRLYPNTERIREISRDIAVRCIQMANKQGVTRDNGKTAAMDEEQLRDWVQGEMWTPVYGTHEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGV0</accession>
    <name>W3VGV0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_05947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS59961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGV0"/>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="7">
        <location>
            <begin position="272"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS59961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="395" mass="41062" checksum="9DE1062095002740" modified="2014-03-19" version="1">MASQAFIVAAKRTPFGAFGGKLAGFSASQLGGLASKAALAELPASTQVDATIFGNVHASDNTAAYLARHVGHHAGLPVTVPALTVNRLCGSGFQSIINAVHEIRVGDSNVVLTGGTESMSQAPYTLSGVRFGNTRYGQDLKLVDSLAAALTDQVPTPTPMGITAENLAAKYGISRQQCDEYALQTQQRYQKALADGAFKDEIVPVEIKSKKATESFDADEHPRAKTTVESLGKLPSVFKKEGTVSAGNASGICDGAAANVIASEQAVKEFGLKPLARIVSYGVTACEPSIMGIGPVEATRLALKRAGLSVSDMDLIEVNEAFAAQFLSVQKELELPNDKTNVFGGAIALGHPLGASGARIMANLTHNLVRLNKKYALGAACIGGGQGIAIVIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VGY4</accession>
    <name>W3VGY4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VGY4"/>
    <dbReference type="HOGENOM" id="CLU_411687_0_0_1"/>
    <dbReference type="OrthoDB" id="2555129at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS60913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="601" mass="64701" checksum="9C4439917442C972" modified="2014-03-19" version="1">MGERNSILFGKLTLRPKRRSVELAASSTSSGRPNSTPNSTSAAEGPTSFSGPADYGLGYSSINHVCSASYRGNRKSRMPHSHAIERPATAEAHAGHEFGRSSTSRSPRRPNKLGSPHADEQPLFVSIVHEALPAPRIQSTVRARCSSTNSARVSSSPPKAVAPLARPQSPFAINSSASQPRFTTIVSERLAVRQPQSADDSDVDQPPRYDVVVDPAGTASVDSLFYAVGRGWKKGIYTTKEEAQRQIRNFPGPLLQHFHDRAEAERFLANAGRFSSQPAKKDDDDWADELAERTRIFAGLDPNSELARRRSTGMSAERREAQRKSRMHFAKHSPILAQDVPLLSPPLSLCSKLSDDLPISPIEDSRASGVGPAPSPFKGMTLLPVKDLASSMAFYIRVLGFSCLSHTEDVQAVMGSSAATVCLRSLRHAPPPTAVSNFSRLSLISTAQNGARIDPLGSGYAVLPPTPEEQPEPTQSWLPPSPESLSHSCTEPGPLKLPATSLSLRSAASAPSGATVLVECSGELEAMHSLLTAKLNEWRLDQAKATHDSFGIAHLSDSARLLGGIQQTPWDAQELHLCDLDGHRIIYTTPLLHTATEASLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH01</accession>
    <name>W3VH01_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH01"/>
    <dbReference type="HOGENOM" id="CLU_015945_1_0_1"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="511"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="852" mass="91043" checksum="739B3CECE9F11820" modified="2014-03-19" version="1">MAKTSTSKKAGASSSAAPASSSSSTSLEQVQALQSALLSSSDLNPLTDLLAFAKKLAKLGAPSSTEISSKAKKDAAVAVHRAVLVLVRSMKSLSADDRIAFDKDVDQDGYLLPYGGKAGNNAAASAALSTKAKEAQNKVSDWIRMRWNETVELLCALLAHEVEALRLEALQMIVELETSASSSLTRIAAASKASSKAGSSSKESPLALSTTPALWSASPWRALTLALIAGPPSLTKLGHGDAGTRYQVVRVHAGVPEDVRAKFIQSGLEEYDDVRFATLREISLALRKPAPSTLGNTQLRAHTLALLIRLTAVPTSADDLNNFLVDELSIPPLGSSGGKKKKKKAAASGKGLSVVDDGDSDDGKDEEEDDDMTGWFSDSDDEGGVRAGATEGEQRRAADKKAVGGLGAAARAAGASKRKRRTLHEMVHSIGAQRGAFSAAWLDLLLPRRQTEKSAAAAGAAPGSLIGGELSLTATHEVLVRLHAQILPHLSKPTLLHDFLVSCLDSRGATALLALNAIFTLVTKHNLDYPQFYTRLYAMLDASVLHMKYRARFLRLLETFLSSTHLSATLVASFAKRLSRLSLRAPPAAIASVVPFVYNLLKRHPRCMAMIHKEWDGDRLNIGPAGVDDPFIPDEQDPLKTQALESSLWELASFGAAAVAKGNSGGPAMGGDEGSILPGEAHYLGSVTSLARIFAEPFTRERYNLDDFLDITYGTLFETEAKKTLQKLGTKPDGTPRRRPVPALAYSLPGGFGAGGSSDSTTCNRVDIFPSESGRARAKASLAAAEEEEQREVEREREERKRKLGVDGDDEDDDEREAREAIEQLKSAERAKKRKVDQTGTHDACAMLFSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH12</accession>
    <name>W3VH12_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="12">ETF-QO</shortName>
            <ecNumber evidence="12">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="12"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH12"/>
    <dbReference type="HOGENOM" id="CLU_009667_4_0_1"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="11 12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="654" mass="70782" checksum="F42D9CAB95203B46" modified="2014-03-19" version="1">MFAARATRASPARLATSALRNGALSRASRSVYPIASTSGSSASLSTLARASPAATAGSSLARAFSTSSVARRATPIEEGDGEPFDLTTVERVSDEVDVIIVGGGPAGLSAAIKIKQLAEQRGEEIRVVVLEKGPEVGNHILSGAVIQTNALEELFPDWKELGAPLNQPALQDQMRFLTPTGSIPMPHPPQMSNKGNYIVSLSRVVSWLGEQAEAAGVEIYPGFAAAQPLWQMDDNGKPIGIKGVITNEIGLDKSRKPKDSFEPGMEFHAPITLFAEGAHGSMTQKMIKQLGLRDQVGADPQTYGLGVKEVWRVKPEKHQAGLVTHTMGWPLDPSTYGGSWMYHMEDNMVSIGLVVGLDYQNPYLSPFREFQRMKHHPFFKDILEGGECLAYGARTLNEGGYQSIPKLHFPGGALVGCAAGFLNVPKIKGTHNAMKSGIVAAEAVVEALAKRAESGSEESIDLADYKTRLDDTYVMKELYEVRNLRPSFNGPLGFWGGLMYSGLDSMILKGRVPWTFHHHGEDHAQTKPASQCEPIEYPKPDGKLSFDILTSVSRTGTNHAEDQPVHLVVKDGDYKGHVERNVGTFEGPLGRCCPAGVYEYVEADSPDQEHALGQKLVINSQNCIHCYTCSIKTPDQSIRWDVPEGGGGPKYSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH17</accession>
    <name>W3VH17_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">PaG_04876</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH17"/>
    <dbReference type="HOGENOM" id="CLU_010017_0_0_1"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="391"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="474"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="782"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="918"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="812"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1047"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS60948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1083" mass="115083" checksum="13C7BBA1E09A9085" modified="2014-03-19" version="1">MSFNFKWPTFSEEFHASAAQMLNSALNRGPKPKVIADDILVEELGMGTIPPELEILEIGDLGTDRFRGIFRLTYAGDAHLVLKTKVQANPLSKPNRPDIGLFPSSNASRGILFAAAPLVVPMHLRLSSVKLRAIVVLVVSKAKGITLVFKNDPLESVEVSSTFDSVAVIQKYLQQEIEGQLREMFREDLPGIIHRLSQKWLSGEVKSEKEKNKQNTDTEGSIPRANASRTKEPALPRSASEPLAVLETASGPGGSMKRSPSKSKRASQSRWDESATGVAASPGRSPPKPRSNIRRSRRVAKAASTSAALLHNELPTTHASPFDAAFPDIENYDPTYGLRPDDLPTHSGFSGLGRLAQRNLGGLKDLTASPTFASPDMPGNDIDLDEAAFEDFDRASDEACSDLDEQQDVLSDSQTDDVDTDADQGVASDDFGDDVSDLDENDQSDFIDTSIDYTRFGYPPASAAFSDTQELNRASSIIFDDEPQSRSRRGKPSSSSGRSGARARRPSSSRSEKSTASAAQRRKPQPAVVYETIPAVGGGTVTRPRVYHIASKVQPPEVDWDDEDTARPSQYGGTPSTRTGATRFGSDFGSATIGAHSSRTNTIRGAHDSPHLGAAFVSRDSSEESLLDLPPESFHSSDASFQRPFAASDAAHSSASDSASRTGRGPSALGSTSRQSSSRDLSDAQWDHSAPSTAPTSSQSQTWDVHTKGDARNKAVGTNMGSDPPSDSGVQFRKNKSTSHNRSKTMGNGDQARIMAQRAGEGPGMAATPARARAAAASRPGFITYATSPPGDSLSWQQSPPSRRSMDRDAALSTSPSGAQDMLSTSPFRSSSLHHGSPRGPSYVGGHFASASNSPQTGLSKAAQGSAAAPTRLSIDASAHFLDLVKSNHTLSPFTRNMEHFTVRSAPVTPGWQTASGNASVVGSSAASGTGTTSGSSQTGALGKQSKGSANAQVQSAAEQRQQRDSSIPPASANTPARRRRTFQLGSSSSRDEQQSTPKADRRQADMRTDGGFASNEHGFAPFAGSGPKPFQAPGSSASSNAESSKGKRSAIKDARRRSRPDSMGPPSEAARMSALRWEAIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VH40</accession>
    <name>W3VH40_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LSM8</name>
        <name evidence="10" type="ORF">PaG_06034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000039">
        <property type="protein sequence ID" value="ETS60041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VH40"/>
    <dbReference type="HOGENOM" id="CLU_112130_0_0_1"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS60041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="214" mass="23062" checksum="D19D1F6204B3A4FC" modified="2014-03-19" version="1">MSLSTLAPLSSAPPTPPAVIYTSNTDTARPQHRPLLLARGSNVLGSALDRGDGRVIVGTLRGSDAVGSIILAASVERIFSPDEGVEEVPLGLYILRGDAICLVGLVDVEKDKAIDLATLMAEPIPETRHVPGTLSTRTAIFNLESALRALRMHSHAALIVQRSSRARNRMEVPTRTTSERQVDLPGYQASRFPTQLSRAELAQATTAVEKDWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHC0</accession>
    <name>W3VHC0_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000038">
        <property type="protein sequence ID" value="ETS60187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHC0"/>
    <dbReference type="HOGENOM" id="CLU_871917_0_0_1"/>
    <dbReference type="OrthoDB" id="2556639at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="319" mass="35327" checksum="D4CD04789732FE29" modified="2014-03-19" version="1">MFPPFRTASFRTCAMQDDDDEFAGGQGFVPGPDGLLRPIQSATRPPAPSATRRPVDQRATFVPAVRSPTPRPAPQVRARQQDEPEGPSRQVLGRRSRDDDDSAAEGNERGRPHPRVISAAMVQMGQWLTAEHFPDIPCPDCSTHHRPCVAPDADSQVEKCLGCSDKRRAKRCPKKWILERTNVAEMVRLTEEHGMTKEDARIQVYGPLGQLGGRWDRKKDYPAMPAAARGPCLPNNTFAPSYTLFGSPPMAGPSTAGPSTRSTPDLLNLPDHRTIDTRRVQDAFLRAVEAYRAEQPTTTAQLNQMLVDLLLELWESMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHE9</accession>
    <name>W3VHE9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHE9"/>
    <dbReference type="HOGENOM" id="CLU_035730_5_0_1"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000010">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004834169" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="142"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS60950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="287" mass="29856" checksum="C9713DA488172299" modified="2014-03-19" version="1">MKLTASLAAALGALAVLSPLTVASQSAEARDLSLGEAGFEARGTSDCDLPVRKHHHKGKKHRKAKQVKATVNSLSSGRNRNHQHKTSSARPSSYYPDIKGSSTQPKSSTPVSSSSSGSTGSSGSTGSTGSTGTSGDSSSLSSFEQTMLDMHNADRAKHSASALTWDSTLASAAAKWAAGCQWKHTPNNPYGQNIAAGTAGDFGAKDSCSMWYDEVSQYSFASGAYSDATGHFTQMVWKSTTKLGCAIQDCSASQMGLGSKGSATYVVCNYDPPGNVIGQFLQNVFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHM2</accession>
    <name>W3VHM2_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHM2"/>
    <dbReference type="HOGENOM" id="CLU_1826098_0_0_1"/>
    <dbReference type="OrthoDB" id="10417812at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="141" mass="15643" checksum="9EDD58545B53D2BF" modified="2014-03-19" version="1">MHVDAGSSLQQPPIRHPPAQHLHFTKQLRHSSTLSANAFSIAAVHMIAAKVEPHARRWQTPSWEKKTESKQCSSDSRPGPPIPSIAPDPTASASIEPHAFSYDTTRYQPPQWDQKIDERSDAKMDPHTPAAISLEIGIRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHN7</accession>
    <name>W3VHN7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHN7"/>
    <dbReference type="HOGENOM" id="CLU_175733_0_0_1"/>
    <dbReference type="OrthoDB" id="3344538at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="83" mass="9334" checksum="19AF45116057C0DE" modified="2014-03-19" version="1">MGSCMSSPSDGKKMKRTDTNPGKNNTELHRTTSSYQGSVADGMRYSDRNTGERDRLTASQLHKSKTLEERIKQAERENKTRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W3VHW4</accession>
    <name>W3VHW4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carotenoid cleavage dioxygenase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_05125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VHW4"/>
    <dbReference type="HOGENOM" id="CLU_016472_4_0_1"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="85905" checksum="B1E20C8C79B99D07" modified="2014-03-19" version="1">MVVSQHGMHRSGSLKRPAVQKPTAPTISIPQPPALSEGPTYPPSDYLADGAEAGPSRPTSIPRRPVLSRRRTSKKDYVHPYLSGNFAPVTTECPLTDCLYEGTIPEEFAGSQYVRNGGNPLANSELDRDAHWFDADGMLAGVLFRRTPDGSIQPCFLNRFILTDLLLSTPEHSRLPYLPSIATLVNPHVGLLWLMLEILRTFVLTILTWLPGLGLRSDQKLRRISVANTSVFWHDGKAMAGCESGPPMRIMLPGLETAGWYTGEDEGPSTDGKAADKKRGKASKGFGGGPPIVSMLREFTTAHPKVDPHTQELLLYHMCFEPPYLRVSVIAPAEVVAKKMPSQAKTIKGQAVRGLKQPKMMHDFGATPTHTVIIDVPLSLDLMNLVRGRPILHYDPAQPIRFGVMPRYAPEQVRWFESAEACCVYHTANSWNDDGKFAASRTELTELAEAGRAGPTGINMLGCRLNSATLVYSAGNLLPPSHVLPPPNCPEKCQLYYWRFDLEDVDAKRISHEFALSEVPFEFPTINEEYAMRDARYVYGTSMRDGTFDAGLGKAAKIDALVKIDAQTLIRRGKALWSQGRLGPCDSVDTRTVEEILAAQRDGSGAPNDAIRIFEMPRGWYAQETTFVPRRSGAGPHEEDDGWLVCYVFDEAAGLHPSTGEVLPGATSELWIIDAREMKTVVARVKLPQRVPYGLHGTLFTEEQIAQQNPIDPAKIRSWAQSVTHADPFSASQLGSTLCTAPGKAASSKFSSAKHVYAAFLADPLHVGAWWIKRKIELLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W3VI89</accession>
    <name>W3VI89_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SART-1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VI89"/>
    <dbReference type="HOGENOM" id="CLU_009379_2_1_1"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="702"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="757"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="791"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS61388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="92475" checksum="46F127D5C420657D" modified="2014-03-19" version="1">MSEFQKEELSLEETNKLRISLGLKPLVADDAPSSSSESAQKDAAPKLDPDAVAARNFQEKQQRDRRQREDAELRERLARAQAKRDAARRLNGPTLGDPEPTLGDASASSSRETLRWIKESKKRAKEHAARRAKELQEQEARAEAEYRDADLVGLRVRHDADEFGEGEERILTLRDTDVLDDGDDELMDAALDQAERDQKNMERKKGVKEYSGLDDDETLLGRKKGVLSKYDADLPESELDTANDSGFRLGASVSAADRQARLRQEAEEAARRDNKQLLTLDYAKNQEVSDYLQEGDVGFKKPKAKKRKKAAKVKISFDDDDDDTPRGAASISAAAEAGAAPDVEMQDSKPVARAARREQTDNFVDDDELQASLAKSRRLKAKKTFKKMTPEMIAKSLAEQRAAEEAEQAAAGTSNGVASPRVANGAVKQEGGEGGLTFDETSEFVRAIRERPMESETRSSARTMKQESPVASLGEVQVKREESVDAGDVPMRELDASDAKAPDEADVAPDTVEVKEEPEEGEAVAAVKPEPSDLDGDASEPLIGRGMASTLSFLRQQCMVPHVDAELATREQQQRQYDAWLASRRREEQLRETERVQSKASGSSVDQATREAQNRSREVEDARLAQERFRDYKPDVSIKYHDEFGRDLNQKEAWKHLSHVFHGKKPGTKKTEKRLKRIEEEQKRERMAAGDTPTGMMAAFQSRSERTGKAHMVLSVGSRDSAPQENDLLDGKPRDGLQLQKPKRAAPKSKKGEQIMSSVSVSELGSSAAASEAAGEGTVTTSTGGGWARIGSATPAASSSASTATAAVGGGGFRPIASSTDSAPSTGNAPFRLAFGVKRRADDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIB4</accession>
    <name>W3VIB4_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251413_0_0_1"/>
    <dbReference type="OrthoDB" id="3365764at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1385"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1419" mass="148553" checksum="3B56FCDEA654A1F6" modified="2014-03-19" version="1">MPPAQPHGGARPPGAAAAVHKPKNGSTFAKEPSKPNSKVARMAAQNNQQDDDDDDDEETTTDDSSDEEAAFEMDGQELWTQTFCATCDCLIEPGEGIAKSSSKTDPPASPAFHSTLKSRSANSNTRGSNASEQAAQIADSNKPAAGSKDALKRTHSAGRLHAKAGGAPLGPHKRTGSAGSRLHALSELRPTTKLHDDKGKGKSISRDASASANRKSPATSRPGSAASNRSHSNSSGPSSFKSNEANASVSHPTATDAQPRPRKRGFLGGLGLTPAALKQQEAELAAKRKAPTPLYCSERCRLIDERRSSGLGELAKYLSQPLMPPPTAVWAPPPPSPWTRSASVSSAPLAMVANTPESECLCPDCMDKYADASSASGAAIPSGASDTATESSSGYIYGRGAAQKPRTASGRLITPLGLHAPGAGAEGYFPQFAPNYAPAAAALNSPRMRAVDAVQSAEAARIGSVLPRTSSAASAGRASASGTDGSVMSSESAGSLWEPRLKPRSNSGVRTSNAAKAIAQDVTSSGTASGISTNTATPAITPRHSMMVTSSSSLASPSSFNTARATHRLSVPGFAPTHEVDEDTLHSSEAAHPHRPSSSAKRSSLLMATSPLKLLDKCSEHHAQPSVNVFSDSVGSPVTRGSLLSRSLASEHTLMGASSITLTNQSSAPMSASQSARAFGDFEHTHHQAPASEASDRWRHETSQSFSDSNAFRSSSLSADVDDGLSHAVGSLKLAQSRASGPAPSAGGRGADSRRLSLFGVAGAPARRNSNAVSIASSASGSTSSGWLRSLSSAWLNWRSTASPAPMQGDSDVFHSTDDSEEWPSRGSGQASRRESNASRSSSHHKLPYAQKRASSLRDVSLASSLGQTSTLHPAQMSRKRSEDRSAGITPTQSLVAKPTIRRGHVPAYVREIGQGGIPGDSSSDAKSDSTAAADERAQRPMRSRVDSLTQVTDANAQRKVNKRRSRDISVLPPLLAPISRSGSSTNLYAQMPRSARAYSTGRAWTAANTPQMYVGSAGSSHQQAAGTAAGAGAHMQPPVSPTLVRSPYNSSFALTQDAQRAALSPSRPNSAAGYHSLPYTAGTSPRAKGLGWGAMTSIASPPASTDSGAFPHSTSHRQSISYGHAAAFANRQLVSQARGHHLNHNVQHAHHAHAHAHHHHAHQHHQHHHQHHHHPHHAHHAHAGHIQHSSSVSNISDAVGGGNERAAVGHLMTLGAPPNGIGQQGGGGGISGRHATMPSALQRTPTPSVPEDGGEMSSRDLTSGDFISRPDSALAGQHGRRHHRTSLMPPPRSRSSMGMHTQRIQPLTSTDATALPAVADTADVVQHHEEPPRTWSYDQLSGLKTYPILQLPDRETHDVYDAAWGLDAGGLAKHLGQVPADVQRGARPAHNERRTSTDQGSVQMGFQPHRKKLFYFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIE3</accession>
    <name>W3VIE3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIE3"/>
    <dbReference type="HOGENOM" id="CLU_2292896_0_0_1"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS61443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="101" mass="11196" checksum="BB20DB429E45873F" modified="2014-03-19" version="1">MAENAPMEVDSPATKQPRFQVKKWNAVCLWSWDIVVDNCAICRNHIMDLCIECQANQGSATTEECTVAFAHSTTENGNSKSTADEHQGLSLHPIQAPFYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIL6</accession>
    <name>W3VIL6_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIL6"/>
    <dbReference type="HOGENOM" id="CLU_2039035_0_0_1"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833094" evidence="1">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="121" mass="13000" checksum="DB997C153E1FB208" modified="2014-03-19" version="1">MRRSGRRGARCRCSGGGTLAATLLLSALPTASVTRSARPKLGAAWFGPGWPEAKALCLSQLGLDLLIAEQVRFYHQIAGSEKLFAASPSIGIPDLCPFHRQLRPCLISTNIQRRSSHATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W3VIW5</accession>
    <name>W3VIW5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PaG_04593</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3 12"/>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VIW5"/>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_1"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000017">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="400"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETS60691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="451" mass="49408" checksum="E61D6D4CB0CF3A54" modified="2014-03-19" version="1">MSSQAKLSATERFELISRDLDEVLGADIIKAVLEKDERPPSAYWGTAPTGRPHVGYLVPLTKIADFLRAGVEVKILLADIHAFLDNLKAPIELVRHRVNYYRHVLTAVFRAIGVPTDRLVFVVGSSYQLTEAYNMDNYRLCASVTEHDAKKAGAEVVKQVASPLLSGLLYPGLQALDEQYLGVDMQFGGVDQRKIFTFAEQYLPKLGYKKRAHLMNAMVPGLKGSKMSSSDNSSKIDFLDTPKEVSKKIADAVCAPGEVEGNGVLGFVRAVLFPIARLRVESEAMGTPVQESQGASRSFVASDAPKGSMFSIVRPEKYGGSLHYSSYAALEKDYVEGAIHPADLKKAVAEAITTLLEPVQKLFETDAEFKKAKEDAYPEDTPVVKKKKEKKINPRFAHLYTKEEGGTAETEEEAQANRDKEEQAKAAAKAAKKNADPTEAARAGVEKVQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ55</accession>
    <name>W3VJ55_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_04328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000015">
        <property type="protein sequence ID" value="ETS61574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ55"/>
    <dbReference type="HOGENOM" id="CLU_080463_0_0_1"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS61574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="170" mass="18745" checksum="93BB5DCAC4843E48" modified="2014-03-19" version="1">MAARAAAADLAKISNLGLGKNTLAQISAFRKRADDAKRQLAQLQQQKTDVDFAHYNKLIRNKDVVSQAQKILAEFKPVTYDVQAQLKAIDAFESKAVEQAQATASKIEAELKDLKATLKNIEEARPFNQLSVDDVVAARPEIGRTVDEMVKKGKWTTPGYDEKFGNLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ80</accession>
    <name>W3VJ80_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_04082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ80"/>
    <dbReference type="HOGENOM" id="CLU_963531_0_0_1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31063" checksum="B3B0D6528A2C8174" modified="2014-03-19" version="1">MAARQSGSGLLITPSVGLTAFILSHARFDHYGNLLDFPTSTPVFVGAGTREWIGGGDEAAEKGEKGLVSFPSSFLKDRTFIETDQIKAKAAHGARVKHAKVGPFERAWDWLGDGSLFIASAEGHCPGHQVMLAKTSHDPTPSWVLLSGDAAHQQALYHPLPAPLELGAESLCSTRPHHDAVYRSVDDLRATAGFFDRASADAIVDGPIPVESAACMQEFPDKAMRTLAALSRLEACHDVMVVLRVAKPKCIVQNGKGELTNDALNPVAQLTRARAHSRARAQIRRRSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJ87</accession>
    <name>W3VJ87_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PaG_04784</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJ87"/>
    <dbReference type="HOGENOM" id="CLU_011037_0_0_1"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07650">
        <property type="entry name" value="F-BAR_Syp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000123">
        <property type="entry name" value="Related to SYP1/YCR030C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="4">
        <location>
            <begin position="838"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="735"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="271"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETS60867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1102" mass="116333" checksum="F52E8CA730F777D3" modified="2014-03-19" version="1">MKRGQKRAQFKGSQEDSSLPPHSPTASSLPPNCQQLRQMLITAKRRVESPRHSAQSVRVHVRPALALPILEASAGAHRRQQIDGVTLLAPRPRIAAAQTRWRAIRISRLAIGSCTLVSAHVNQIRASISPLTSSKETRLLSPAHPSRPQSHPSQPSDLTVPNSAGPASSGRPPLHILATSSIVFRMAESNPGAAFAPNAYANAFVGAKPRDAANLVQQRLRKAKLFNEELADYFAARRELEETYLKQLQKISKRSFLSDPSSIPPGFAPVYERLVQELAEVASAHGELEKRIADDCEAPIRNASSKGEWSRIKDHDDSLANTLRELNSLESQLQKDQKKLETASSKKASQANAKLSETERSIAQTMELWETEAPFAFEAYQRIDAQRLELLKETVAKFETAQSDAAQRIMSTSEKTMQQCLSFDTQADMQDFILKNGVLGADGTARNGRRPSARPPTTSSITPGLNRQNSVAGRSISSRTGADSSMRAPAGRTNGAGMGEFGASSASIHSADRTVGSTNDASTPSKGAGSTLKNAFSRFGRGRANKDSANTQTMYGGLPDEPAGDSSLSSMTRSNTVRQNSATAGAGSSSRNPTLLTPGDESIDSIGPGSGTGLMAPLTPSTAPVRKNSVLASSAAAATPAPSAAPVTTGAPPMVDSEGYSIPPPDRKPWETPAALGAAGGGAASGASLLDDAEGDAARDTFDTSLNNRVSTMNISSQPIAEDASRDKAALERMKSTLLTSGPPSRRGTTRRDRRDVRNTTYNPAFAGVGAAGDDSRLSQFGALTASPNSSVPGSPSPFGAQSAFTGVAGTGRHRTQSIASVASSTANANPFEASASTSPIRASLTERVNAIFVGRDVSKVMVVGELSVAVGASLGAAEPVHLRIEAFEQLEKAAPNPAFLKPVPGGSTPGEYLLDVKAVLEQGGGVGLPGSGAQAVVLKYQLHISDSRRNDFVPLQLHAQWRCEAHQTSFLMTYAPNAACRLTDGDTSANTPAVLEDLQLAVNISPSSVTNIMSKPTATFVGDTSSLFWKITDALSLADTEPRKVLARCQISGSPTVPQPVHLRWKIKGRSIAPIAIAVRGDHTVGELIRTCTAGKFFASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJC6</accession>
    <name>W3VJC6_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04143</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJC6"/>
    <dbReference type="HOGENOM" id="CLU_012393_2_1_1"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="200"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="308"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="473"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS61649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="626" mass="68216" checksum="938EFA3C10FB08A3" modified="2014-03-19" version="1">MSLNDLTQGAIAQMVQTADPSNSVQNPVCQILSIKKIQASAASASSMGDRYRIILSDGVKYAQAMLASQKRSMVESGELEKHCLVRISQYASNSVQGRRILILLDLSVVHPPTADRIGSPTNVDDSIKPEGGVKQEGGAGGALGNSNVGNNSAGRTTPATSAAGAGKVGGGAAGRPGGSSVHAGMPIYPIEGLSPYQNRWTIKARVTSKSDIRHWSNQRGEGKLFSVNLLDDSGEIKATGFNDAVDRFYSMLQENHVYLISKARVNIAKKQFSNLQNEYEITFENSTEIEECTDATDVPEVKYEFVRINELESVEPNQTCDVIGVLDSYGELSEIVSKASQRPVQKRELTLVDQGQRSVRLTLWGKNAENFPNHAGVDEKPVIAFKGVKVGDFGGRSLSMFSSSTMLINPDITESHVLRGWFDNDGAHAQFQPFTNGGGAGGAMGGGAANMAERRTIAQVKDQNLGMTEKPDYFNVRATVVYIKQENLYYTACPSDGCNKKVTPDHEGNWRCEKCDRSYEQPEYRYILSTNVADATGQIWLSGFNDDATKLMGMSAGELHKLREESESEFTAVLHRAANRMYTFNCRAKMDSFNDQARVRYTISRAAPVDFAKAGAELVDAINAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJP0</accession>
    <name>W3VJP0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_04907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJP0"/>
    <dbReference type="HOGENOM" id="CLU_716050_0_0_1"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS60976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="37106" checksum="15B6ABFC9F13E78F" modified="2014-03-19" version="1">MDIYDPGLMGAAGRVGTSTPSTNEADQPAKTELDQNVEKLVGNISSWWSGIAKKSQDSLAQARKEVETRGGIVNFAKAEYAKLETSIGEAQKKARDQSQAAPTASDLEGEQTSESVAQSETSKGKQRAMDETTFEVQEGAQGQGPTLGASISTLFGKLTADPRLVSLQQSLTSTLQGVTSPKDGEPGQKNLQESLSKLSATIQSHLPHLDLKESQQLATRYLHATENFAREMQSDMKELVGDLVRIVPPEEDESASAAVEASKETAVEAPVPQASPKPADSKITDVAAPAHDEEDFAWDEDDEEAAAGADSKSAPAAPEPKPEPASAEPAKTPTKPSEPHQSDEDSDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJQ3</accession>
    <name>W3VJQ3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_04923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS60991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_228003_0_0_1"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF14">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 92B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="893"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="1361"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="2130"/>
            <end position="2323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="602"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1225"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1906"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1955"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2325"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2473"/>
            <end position="2574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="612"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1923"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1959"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1976"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2325"/>
            <end position="2352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2399"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2424"/>
            <end position="2433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2509"/>
            <end position="2531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2545"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2557"/>
            <end position="2566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS60991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="2631" mass="283447" checksum="0A143A9D6A6D7AB3" modified="2014-03-19" version="1">MPTPSSQSGPHPGSARAQNQHAQHAQHAQQPYYPQAQPLHHQHQHLQRYQQHQQQPSPPASSSSQQSQAHHDRAPPSQPIGRSQSAFNFLLNKAKAPFSSSSSSSTLNASTSLSSLSVHQEDPFDDTTNHIQYHRQLQNDHAFPQAPPSAPPARRTASGGIEKTARSHPFAHDASQPSKSTGAPFSRPSYSSEEPQNAVASPTKRGFFGGIGRDRKASTASINKPAPHKPNFSHSPLSKPQRTDPTMAANYAHFSKSQSDLHSRADYPSPTNMTVELPRLPAVYHNSNTAQPPIDRNRYLRSPSPAMNFSRSVDDLSIAEQQPASPYPISPAHGQSSSSLATAATSTSPGTWGEHGIPVPQPDWRPSDMGTLASPTHQSAASFQRFKPGHNKLDSVASQLQPSSGSVHSPPHNWSGMSPPQYSYMQSSAAPSSARADAKHARKASKLMGKDSSARGAVATSLAASLGLTHLGAASAAAVPPLSILTTAEPVPLPPGASFQGFLARNANISLTLAQLSGHDHGKGKDKEKDVTKGWKPYRVVLQDGRLCFYKPPSNISDDVKALFPTGIVRGVPDTPASSASISSLTADQLVRSGLSKQDLLSATSSTAEMTSPLASPSLRPRLPSARPNKSATTPSEVPTTPVAAPPPAEADAPRHQSWLKPGKHPNLLLVDTVDAPPAWSDRIQAGTSEALAHEFVHATQFPTEQAEAQASRRSILPSPLASGSRAAPSSAESAVESFVVAVLANASSSAKDAPQDANKQISTFFLDVVKQAEELTSAGTDISQSISASLPSLASRLRTLLDVATRAGLFGILTGETLQKLAVLVSMDIDELDDKMQAYASPILSLSDAQSPEQPRDWIARLAEKEAASAREDLRKLRSSLELSDDLLLQLEPLEIAQQIQAFHVDALRRLVISGTSFLDLLHPITTDADSIAALSFDSLSPHPLTTLALSHLLKSSSSAQDAPNAAQNGARHRASVLRHWIAIASYLLSLGDVAGWMAVCAALCSRAVTRLEQTWRYLAEGDRVLVAEEWAPILSSLSWTEGLAVHVRPRFVGDGTQSFTTSPDGTKLAVVPYLGSAFYRTLRQPNNPSTSPSGMLSMSNSSSAEDAAHLWVSVNEWRSAWQGEPSLTLAAHSEPVEEYQAALQLLFQNSNTPVSTMESNMERSFQLEPKALGNVDAGSLDARERLSLPSSADADLPLAPLLFPQPLPLLSLLNMSQIKASLGRRNDPRANQIHDPQATITSRSITRPSLAGSPLARASAFSPPLGRSSRNAAFSGVEWSTISAPTKWDDASNGAVKIGNELVLRLIQEANLSLPGSPMTSKRFSQDFGRASRPLSQVSKRSSLPASNRSSVIDIVVPVQVVVKAATLDRMIDLLVMGVQHINVPPISSPMDGPEQQSAPQRKTRLVMDMESYRTTFLATFRSLCSAPELFEQLQKRFSTAIMASKELAGADEFRSSSQFPSWIGVIPAGSQAEPTDWEMVYRIRMGVVLTLRLWIDRFPQDFVDVDDLYHLALNFLRHPGMEVTTEDPDQQKVVHALAQLRSMFGSRIMGANARQEERSYATNMAVQISDSRQQADFDFDRASAAELIEYLESIATVFFDKIVDRDLLVVSEIFEKFAIQPTAWYTVKSAGTASGEEDKPITNMYTLLDVLRAPGGTNADASKDSTASLRLRMPSAIHDALAAQSLFRGWIAIHIVESGIGLERRQERLSKLLDALWLCRARMLKLRNDEMTASANAQAGNVGPIADTSLPFREPTIGSFVESAIVNTLGSSESRIFLRAWQGVAAARGGRGDGIDDLMPKQVDADLRSAVDMAGTPDIGWILACLAEAATRAPSVPTSTSDVELIDFEKRRTMWALIDGAVRVRPACSLPDLVDVAGARLRLMQSALNRVIWDRRAFREEAAKEMRNAPPVRSDAKLRPTTSSKALSGLSKQQQEKLRRDRAALEMLKSLPSAPPISSRVSSMPSSRARASNVSSTAFPSMPQSSDKATMVQAPPPDKATIRARRMTALFKGAVRPLISLDKPNEPSKPTAELMRLTPLQKPSLVAGLGGARVSVWNNAQRSFVFHLTSQEGAKYLLQTTNAADLAEWISQIERASKEYAGPQLLDARKGGVPSKTRAGPAPLYARPLAELAEREGHSVPTAVERMFAEVEARGLREQGIYRISGSKSAVENLRTAWDQQPAESIDLSTGEFSDVHTIAGAIKAWLRELPEPLITFDSYDALIATNAMENDDRLYAMRDIIWKMPKCHFDVLRRTAEHLARVVEEGEINKMLAHNVALVFGTSLLNPPPGPSSVAIGFGNLGKAANVVKTIVTMHEWLFEPEPEPELEPEPEPEPEPEAGPEEEAEAEEGQRLGAQQNADIEQADPGSASATEAGVEEASSPVESINATRLRGASISSSQDSQPGLSKDVPVLATRQDEEQAQSDEEEASTLTELAPRPRRGGRARPLTIVGLDGLAALGANEDIAKVLESGTTPNAEASVGEDGTSESQPSQAAPRIVLSGAGDESDREADGDEGSDSGDDDDDSREQDAVADATEVDSEAARVQEKEGNADEASGAAASARPRKTRSTYRDSVFTSYSIYADCFDNMRLESQSSAASMVKRQSMHLLNSPPVAQEAVTGDAAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJT1</accession>
    <name>W3VJT1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJT1"/>
    <dbReference type="HOGENOM" id="CLU_685358_0_0_1"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000017">
        <property type="entry name" value="Potential peroxisomal lipid carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="2">
        <location>
            <begin position="278"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="402" mass="43588" checksum="968113012EEA92E8" modified="2014-03-19" version="1">MQARTERDEAERAKGLGKIQAVLDRVSAGMKCARIRSLSFSSAPGHCAQELQGADALPSARLRHGQPAEVHDSPVDPGPPAGGQAPERARASGFEPGRACSSLLMRATQQPLDPEDSVDGRAIFFFLARADAPFSPSMKMRSSFSFRPARLSDAAPVFPPPRPSSPPSGHPWPYHANTMSSSTKPDERMKAEADQALHTQEDLDCPGFESSRVFALSAQLLANPPEGFPSRKRLLRSLQSIYLFVIQPSSAIDPSNPRTKPVDGKVSTSGGALRPAMWYADMKNKGVIGRGQPPKTVLGRKRKADVVIECRDRDFMELATGKVQAQRLYNEGRIKIRGDLDRALKISSLISHERSKIYGTSPASASVEQKVAAVDHEREGHASRNDDYGAGSPAPVPDRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VJX5</accession>
    <name>W3VJX5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetyltransferase involved in MEL production</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PaG_03511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VJX5"/>
    <dbReference type="HOGENOM" id="CLU_502670_0_0_1"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETS61963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56509" checksum="4B574949FEE91D28" modified="2014-03-19" version="1">MPGYDAVAVPVLDSTLGNTDIMTRISLTFPTQLSLALLQNSWYELVRAWPILAARVRHTPSTPSGLSFLIPQPDKVKELEQRSRTTHKDLEKHIVIVDASSRSIASFHPIAAKAIESSLSRDTVSVGAAPDNADSLKMTCCNATTSLKQLIGADQAYITAHATVWSDATTIALAFSHIAGDAFSVKAIFEAWRQTIESAAPAPLQGVGVDPFITYLPPHGKNSKSEDTDKRGERDVGLPLGFFQYGFIDKVRLAWNLISDIKIKRPEKKFGQYYMYMPEEKVQALMAQARADVDALVSASDDSEKQALDTRISTFNVLLAWLLQNIHAANPKRKRMSTVMTIVNAKTRPPARHDPSDYPPHQLWGGALGVPLEPLASGDYASLPLGQLALHIRTSLTAQIEPANMQANIVTLLRHTRWAKPSGKLIFFARPNHYLSGCTEWRSTRFGEVDFGAAASPPSSVKPVAIGTDMEIAVSKRNRWVIFGDVGGGVWFSGFMTHKEATHRDGFGRYQHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK24</accession>
    <name>W3VK24_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_233517_0_0_1"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="626"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1409"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1947"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1412"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1999" mass="210463" checksum="5F47FD282FD7C652" modified="2014-03-19" version="1">MKVTNSFQCTVDYNVAEDDKVLSLGLLDGLVRLIVNIVERSKACLYESRDDTKLEVMLGEDVERPKLTFPTPENCRIEPVSEAVSGRKDHRIACRLLITNLLLHSRSYKAAAVSIMQQQGTGSGSGFGSAFGSAAASGSGFGSSSAFGSSFGAASGSNPGFGPGSGQSTPGAGGSSFGSFARPQPPSASTSSAPPNTFSRPPSGPSNAPSAFTSGFSQGGQQQTGFGRPRPFTSRPRPQFQQQSSFSNSRPFNPGQHQHQQGQEQQQQQSPFGNRPRPFTARPSGPGGPGQDGRPPMSGSFRGGRGGSLARPGRPFVSNVDGDTSQRGPTDANPNLAGASGNHAYQPRPRPRPFANKSTTFNTQPAATPSAFGSQSAAQAPATPSAFGAAGSSQTASAPAPKPASIGFGQMSASTPSIPPSNGFGQSSSAFGSSSTNPTSGSPSLFGAPQGAAPASASAFGASSSSSAFGSTSSSAFGSSSNSTAFGSTPAATQAKLALATTAAPAPSPAASAPPSTFAPAPANAAPTSSFSNFLRKDRTGTSTPAEGSGSPMPSANFGSKGAEDEDELRKKRFEEAPKVGNRFLEMKGGREALRNAYIKSGVLPDPDKPTDLALAVKLVGTCQDMCPEFEREEREFQKELDPLEVYPGTDRVDPRIAVKIYRRPAAGRELPLPEDVRPPPVLKRTLDYLFHDLLPADPNDPRFTAVQGFLWNRTRAVRQDFIVQSEGGAIAIECHERIARYHILCLHWRGGPGAEGWSEQQELEQLRKTMRSLIEFYDDNRRKSATSAGAVVQPSPNEAEFRAYNLLLHLRDPETLREAELLPGDIFRAPAVQTALNLRQLAQRSNNLEKRGQPRNTEATLNFFSKFFAELRKPSVNYLMACLAENSFSSVRIGAVKAMGKAYMAQHRGLPIETMRNALAMDSDEQVIALCTHLGLEFEYDGPTPAAVKIHKTAAVKEDKPLISPFSLTMVEAKRGSWKSADVIDGRASGAGAILLDMPNAAQGFAPVSSMAKPAPGPTSSSLDFKAPSQADGSLDSISMLKFGQSTAGQGGQGTSAFSASSPSKLSAAATSFMPSAFGSGSASSAPSTAAPAGSFGGFGGFGGSNATKQESPAQSGLPSFGGFGKEPATDSKPTATTLAPDTKSPIPSLGSAAKQMTPSSLPSFSFGQPNTKAPSAAATTDAKPASPFTFGPSQTKDAEPSKTTMPSFFSSSSKPQDSKTEKPGDAASGPSKLADADAGSSAPGATSQKRRGSDPAAAAASRAAAAAVAEAEAKVRVKRKEAARAQAVERAFKTLSSEAIQSAAAKTAAAAVQEERARRRAASRDELLTRLSDKMWAQLAEERVAAAAEDAARKAAAEVLRSRSGTMRAWQHWRDALEERRDREHQKQRLETIRSEIKRRNVLGRIQVDASGTSNGSAQGTHSKRASISQSLLTGVRRTSSGRDVQVTSPQRRKLAGERSAHGDDAELSAQWTRVRRQRGELWAEGSLLDRLADHVEELLLHFRPADLDGLVVLYSGAPGQHVASNWLRVKFGFSPSVPASKDDGRDVLEVGLADGSHLALVDATRSGDGATLESMVLAEHEEHSEVGLVVFETNPIACRASSASQRRAMVTEDRSRLEEIAQSRVVKQSRLACRLLLVTWGDTDTQSTRSATSDGAIEDVEMADGTASESVAKDATASLITSLGLDPSKTVRSTGAVDGRDSHEGSALLSRAFERVGVLELADASVSIESSLRMLLARAMPDLAPNLDLDGARRVTLDEVARELVDQWSRTCVLLCDLVCVFPPSVLSGTAVDLPAKAEDAACKALCILSALANYVVRAIVSRSELTPDAEVVEVAVPTRKGLVEMALEQLEALPEGVAEQREALRYRLLSTLPERGLEATVAHVNRMHAEGMLRIALGALERVWIAPLHGADWSAAVEGMANLCAAAVREVAAETRRIAKDARAAGAGGAKRVRSEASPPSAAPEDVKETGGSAVDQLRQLIARTKRFLDTPSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK25</accession>
    <name>W3VK25_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_05111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK25"/>
    <dbReference type="HOGENOM" id="CLU_130038_1_1_1"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="107" mass="11802" checksum="258C9A695558C05B" modified="2014-03-19" version="1">MSADKSVQWVTLVSEDGYRFLVDNTTVMASPTIKTMLSMGEGGGFAEAESNTARLQIRGEVLEKVIEYLHFKTKYGAAADVDIPDFKSRIPPEIALELLMAADFLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK27</accession>
    <name>W3VK27_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_04004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK27"/>
    <dbReference type="HOGENOM" id="CLU_711709_0_0_1"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="387" mass="42397" checksum="7649A6F5EC1F91BE" modified="2014-03-19" version="1">MASSSSSSRRLVSGASQEGLKHLYRTLLHQARLLSATFNDPILYSSHRFLARKNIEPLLTSSPPSEGWPPSTASKRLARARLHRRQLADANHGWEHAVHRALSLAYARSGKLRRDALSDLSPKPAPSAQLDEGEVPRAEQVSPVLLAIMTNAATMNGAAVKMAAHMTERPPPPFLPKEDDPLVTMFGRAKRARTLQNAMARYRRTYLRKIKLPIDVVSAETPAPSLFAHLENLARGQGPRVGDRPYLAAARGAVEMYRSDVSGAAHRKRSLRVHGWSSHPKHYTARAQRRLYGRILCDAPLLIIPAANEMDVAKAKNDPLGIRARLRAAHQVAIDEKTPPGKMRAVTSSLAVGASSKGRAESPGQGKEVQHLLAPSEVHFLKQNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK69</accession>
    <name>W3VK69_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_05157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK69"/>
    <dbReference type="HOGENOM" id="CLU_329053_0_0_1"/>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="126"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS61197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="865" mass="93066" checksum="1529508330F3F576" modified="2014-03-19" version="1">MAAAMPPESARIRPGQYSRQHSAFSGSSDPHSGKENEPLSPQPHPSAWGRATSPSKAHPIAIDPKFRLRGTSPEDTERESRSRLSSSSSPTKKGLRSRSRSRSRLFGKDKTDTLNNQADAPQSYAATRTPDQIDADFVDLLDELQVQPDLRRKLLALNSTVKASMLQGQATLSLAAFGLGDGTAGATPSSPTKRMPIPDLLKARAASRPASVHISSPLLGQDAASNYASLAADSAELMAPPNTAQLFGSGPPRQVSSGSIDSASSGSAGHTKQPNSTSRSAIRDAFKKSTPNLGQGGSFISLAASAAGGSASTPSTLRPRSMSFSKDVAASFGKETPESFATMLKCTDASRIDVARVKRMRAVLAAESPTWISAFISPACAGYDAMLARLDELLAMEWREEQHDDMLLHELLRCFVALSTTEVGRDALASHAPRPFRQLVDLLFSEKKPGDLSTRKLMIELLAILLDLQLPASQAHSHSSLNYLLELLRNPSDPAKDAVVDFIKQTHAPRPFKTYIVEIAGVCRDYFWIFCHSQNLFWRWDELQDRIDSIQGPKVPGGMTGGVEFEAMAYLTAHLRLVNAIATVLVQLKAHQLPRPAMTAQLFHQNLFASGIERVLATLRRASQHYYPTTHLELARYLSLANQAGHPVPYHLADWIESPKIKTAPLLPPLELPSSQARASPYTAASPQAGYGLAGAFIAPSAPARQSSFQNGTDDSAPVAVTTISRSNAMRSASQSPSKRDRMLAPPATAEPAPAVATTGDFWDFDTAAPSREVEVVGFDRRLDSQFFAPSAPVAPEPPSSPGMPSSSTSKRILGLSEAVTQDLKPPNADRPKGSIVGSAVQQWESRSISHAPTPIQRAKLSNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W3VK98</accession>
    <name>W3VK98_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate-binding module family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_05132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000022">
        <property type="protein sequence ID" value="ETS61176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VK98"/>
    <dbReference type="HOGENOM" id="CLU_618369_0_0_1"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS61176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="443" mass="48499" checksum="83E83416145481BA" modified="2014-03-19" version="1">MVRAFHRPSAPTAMRPQQLRCPRPQRSELIVTHLTVVHRARSWSGRPRLIEAHPVGLYQVRKAFGLLCHPALPFLSNSGLAWPAPALTLSSYAYTALPFLRLWHTVSAAQSTAKCFRPPRPNVQPGSSSNYIGARIPSSLHHLSYISHLTSSANMYAKSALLALLAGVIGVTAYDPAHMPAKTDAQGGQTGYNDCQQRYGASNPKAKCQNVFINSVKDFCLWGPPNTQSSDTVGNLEAVMVAYCMKSGYGTRLIPDGTIKGAHFLKTPSFVQVTGTGDFTKIHIRAGDEGGELDPHGATGSGNPVGGHVFTRAFTGNWEELPEWQNFMSANEYCFRACRAGPWAKNWCPHIYDVMGCMWNEPANYDAGVFEQCDGIEGQWPGVYSGSTWYQGVRPTPAAQPAGKSSNCRYYPSISNGPAIKTPSKRSVMATQVKRSPEWEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKM0</accession>
    <name>W3VKM0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PaG_03617</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001734_1_0_1"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="339"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="590"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1441"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1445"/>
            <end position="1481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETS62060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1481" mass="156885" checksum="41D67381E458DA08" modified="2014-03-19" version="1">MSSASASSYSSGTSSIGLAAQPLSLPKVMLRRLARQASQNPIEVIVTIFIIVTLAYFQLLHAVTHSNFFEPISIEATSLASSSPSSGLFKWAGAGKKDAKSKSSPLSPAVSSHVDTVFVRKAGDANLWQPLSHLAQKRAQQGLDDTTALFDPSSPTFFVEPVVVTSARESYMSAQIEQAILPTLSANLAHSLVGQDVTPNLVSDKDSQHSAFVFGSTFADPAASTNGAADQTLRNDFLAKVVDPSLLSNSLASAIKSVPRPAGAVAKASVAEIDDLYDGLRVVPLVPDGEFNPYAPNNLKGKRAAGNAEEIQRIRWMAYAVKALVVRFWALLKKADSADIFVMLSAYILMHGTFVNLFLSMRKFGSNFWLGASVLMSSILAFLLAITFAYLLGVTVDPICLSEALPFLVILVGFEKPYLLTRAIFTHPDITPSANALTSKERSELILSNLDHASKPDIGTLGKTPTAATNGAAAVSREESFVRALTERLKNEDSLRWAEPTPTPAHEIVVSAVNRVGVPIIRDYLIEIAVMAVGATSGVSGLREFCQLAALILLFDCIFLFAFYVSILTIMVEVHRIKVKRGLRKPKLSADLSLDSDSPPTSPLSDSSASREPSPTPSQRPLWQKIFKTVFGYAPSEKRRKSENPLGRLKILLVTCFLVMHSFNLISTLTRQSAISRHHATFEPSPYQVVVEQSPIFGPAASSSIAPLLAQLSLSHPANVDLVAHISEPTILVLLEANESVSASRSPLASAALNASGVYAQITSAGVRPVPVGRSSSSLAVLDSLMSGWTVIVGDPVISKWMSLALGISIFLNAYLLKGIATGNAALSEGNAAGAAAYAAARFIGAHLDSEAKAIEEHGERVRRRWSSRENGKPVAPVRGKSADGLNDYHQRLAQMSATAASGPLNKLARESDKVTASSQSAPGVNAVPAEAIKPDAMDAVTKSNVAPSSEGQGAVAALEDRAQQIRLQDATYVAPNGETVVRPLEELVDIYAGGAGVFFLTDEEIVTLSQNGKIAAYALEKVLQDHERAVRVRRALVSRASHTKTLESSLLPHRDYDYAKVMGACCENVVGYMPIPVGIAGPLNIDGQVMPIPMATTEGTLVASTSRGCKALNAGGGVTTVLTQDAMTRGPALEFPSVVQAAKAKRWIDSQDGASTIKAAFDSTSRFARLSSLRCVLAGRTLYVRFATSTGDAMGMNMISKGVEKALSLMTEEYFPEMKVLSLSGNYCTDKKPAAINWIEGRGKSVVAEAVVPGSVVKSVLKCTVRDLVNLNTKKNLIGSAMAGSVGGFNAHAANILTAIYLATGQDPAQNVESSNCITLMEAINDDQDLLITVSMPSIEVGTVGGGTVLPPQRSMLEMMGIAGAHSTTPGANAQRLARIIAASVMAGELSLMGALCAGHLIQAHMKHNRSVPSTPGTMTPLPRPETPKHFAASMTPLVAPPVGQSNRGSPTGNRSISMTNLAIPASDSTGRAASLSSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKR5</accession>
    <name>W3VKR5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_04424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000016">
        <property type="protein sequence ID" value="ETS61397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKR5"/>
    <dbReference type="HOGENOM" id="CLU_017584_1_2_1"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="114"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS61397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="521" mass="56953" checksum="A2EBEDF2304C679E" modified="2014-03-19" version="1">MADSSAAAAAAPASSAPDLSTLTVAVSSATLSDDGSATLSRRGEYGANTFQLPEGLKRLLANMYDPDTNPQGIINAGIADNSLCRDELLRYLLAPHRLQLSPADLTYADRFTTSTRLLEAIAKLFNEYTPDWPDTTRSPKPRTKVVPDHIAIASGATGILDELFWNLCDEGDGVLLSTPYYNAFDNDLTSRAKAQVVPVHLPLPGAARESLDKTAFASETVAAYEAAYERATKQGVKVRALLLCNPHNPTGTIYPRDTVIALATLAAKYKLHFVSDEIYARSCFATADVREPAVFHSILSIDVVEECGLDSAYVHVVTSASKDFAVNGFRLGVLVSQHNAALLRAMASVGLLSQSASPAASLWHTWLSDEAFLRWYLAENRRRLARAYEHTVQWARLAGIPYLPSNAGFFVMLDFSTKIGITKETGESEAAKREEDFVDRLLDCGVFVAPGTQYHHPNKGWFRFTFSMQPKTLKLALERTEQALRLEESVEKNRPLLDLDSGGTPAPDAGKRQSWIQKLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKU3</accession>
    <name>W3VKU3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von willebrand ring finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003080_0_0_1"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="185"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1313" mass="141111" checksum="D956C6077F163E76" modified="2014-03-19" version="1">MGLFDVGSLRSKKLSAAREASTSDSQFLQRQNDQRLAADLGLYSNSRQAASTRSLSAQHPASHHAAPAALHTKRSASGMSSTDALRQSKLERMMGAGVPQIQVVSRNDRRAPSAQIHSISASVDSHHHRSQPSQHTIRGPAISRTKSISEASDAHSSFSRSFSTDISNSMSGASTTFTEMAEVDCPVCLEPLSHRLAGEKPHVVPTCGHALHNACFTAIYGSPEALLAAQNSASRLRPAGSASRHSVGPPGMCGVCRKPIALGEGNTSKSHKLAGINGLAAAAPAHDADVAFADADAPSRAHHDDPLDLPSSTKHRHVMSSSASFSSTSSNTHTLPTVRARPEFPTIYCKPNGKQPAKLNVVSVLSIEVPSRRSPNDPRDHALDTISDEYAEDSLSNGARDDDDDHSDDLKRSGNGWPASANDAVSDDCSRSRSRSPMPDARVGFTEQGDKHNVMARVESPNDQGFSFGATPAGLPALDPTRAILDDLQQRVADWKGHSIEHFGPLVLHDLLNIRQDSVVREFHVYLFQEALLCVTEEKRKGLGRFISNPPANGAAANDSDLGKPALKLKGRIYLRHIRRVLDSSVAAEHTLSITMDDENLDQFVLCFRDTGTMSVWRSRLQELIEPADASASASPAVLIAEPAVADAPQAQGMPSAQVDEVAKPAHAPGEAGAGLGLSPHRNGGFQTVTSGSASVLSGKSGSQQGAAANAQSRNSRRLSNVSSSQHSQHGNGAAAARRISASSDAIPSYQQWSSSGGLDPRLPPPSMLPHTPIDLVLMISVPSVLPEHVSGSISSSAALKLRLIRSSLDFVIHSLGPNDRISLVAFTVGIEGEVKRTGLLNPHREPSRLLLEEFVQNIGRPWETQDADPFRVDLSQLGGSSERIDSVTAVNVGLDVVLGRKAKNAVTSMMLVNDTSDGPKRNQMDLVMARAEAANVAIHCFGYGKTHDPSSLWLISNHTRGSYTFVREWYQLRECLAGCLGSTMSVALTEVKVHIGVPHDNCFRIRKIAGLPGAIISSSGKDVDVDIGELKFGEAKDLLVELELDVASLLPTLLEQRRESKSMALGPIEQGSATDDFMQRMGIQDLSLADSDGAEGFLEQMVEEIGVFEADLSFKDPATGMSTSRLANPGILTLEIDTHSPDPLTSGPAGLAAIVAEPTVTRRRLEVLVSEMMTRSLLLISRKNYAQALRVITETRRIIDTVVQALNGPNQAKRRSVVVHRSNQRRVREAANARTIASLLAMMGDLDVLSDGLEHQHRSSFDRDGRNFGAQQAMILRDQKAWTARTDTEHLYFRDDNAAAFTAWSASFASMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W3VKW8</accession>
    <name>W3VKW8_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_03764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS62194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VKW8"/>
    <dbReference type="HOGENOM" id="CLU_1759604_0_0_1"/>
    <dbReference type="OrthoDB" id="2544298at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004833158" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15725" checksum="5F46D7A79BE7CE1D" modified="2014-03-19" version="1">MKVLYTILALAALCMMVLAKTQRVGDECNWSKNCQQYADGVGPAWAGGRITCAVPQDHSPDSCGSGNDNRNNFYGLSELCLLPNTAANAASTKVTAPKLPPSTASSGPRTGWPTPGQRSATNRPRTLVNSFRTPSLLAPSTPSSYRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W3VL12</accession>
    <name>W3VL12_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VL12"/>
    <dbReference type="HOGENOM" id="CLU_012970_2_2_1"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="48"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="587" mass="64130" checksum="E38492774A95381D" modified="2014-03-19" version="1">MSHPTGVVERAEEESSFSESQETLNDKQIGVIAAEAGRSVADWTLWVGIFGIALVAYLAGLDNNTMYAWQTAATMEFGNYPAYTAISIVQAVLIAVGKFPIAKLADVFGRGTAYITSVVFWVLGFIIVAVAQTTRDVAGGTVLYAIGNTGVQIMQQIVLADYISTKWRGVSIGLVSLPYILNFWAAAQITQKIVTVNWRWGPGFFTICAPVAASFIIVVLFINQRRAKAKGLIPAHPYKSMPLGSAIWAFLVDIDTLGLFLFCGGFLLFLLPLNLAKLQADGWQTGWIIAMLVLGGLMIIGFCIWEFFAPKPILNRRWRLNKDVHFATAIGFFDFFSFYTSWVPAYTWSMIVMDYNLTEAGYFSNCQSLALTVFGITAGFISLGTKNYKWILVSGAVIRMVGVGLMIKYREAGSSNVQAVFPQVLQGLGGGFLGITLQVAAQVSVRHQDVATVTAYFLLLTEIGGACGNAVVGAVQTNVLPGYLDKYLPMLDAATRAKIYASPTLYLTTYPIGTPERTGIINAYNDYIHILLIVSIVLSVPPIVLGLLVKNRKLNDKQNCVSNELAGMKRVSHDSEHTSDESYEAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLB0</accession>
    <name>W3VLB0_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="4">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PaG_03366</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Mg(2+)(out) + ATP + H2O = Mg(2+)(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="4"/>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLB0"/>
    <dbReference type="HOGENOM" id="CLU_002360_6_3_1"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="865"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="902"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="974"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="108"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETS62290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1000" mass="108131" checksum="3AA55FEEDB48DA8A" modified="2014-03-19" version="1">MINDGATEIAVLPLHGHSDQAVVEDVRKSDIKISSPSIEADNGGDFPRHADPELSVLVQAKSSRFVRVKQALASSPFARLLGMRTALDHTKKAAALAKEEAVLTTLAHWSIRPLDESFAQLASSPRGIHAKAAASRLKLDGPNQVASSQKQPWWKLLISNIVNPFNAILTILAVVAISTDDHSTFAILMLMVVLSVSLRFIQEHKSANKVYALKSLIDSSCLVLGRNSDDEQKPVKIDRSQLVVGDVIRVATGSVVPADCIVIASKMLTVSQSSLTGEGLPVEKYALGTSSATNLSSANSFDCPPGAEVPCSAKGTSATMDRPNLLFMGTHVVSGHADALVVATGDRTYVGTVACVSDDLQVQNDFQRGISHISMLLLAFMLVMAPTVLIIDGFVTKDWKNAALFCLSVAVGLVPEMLPMVTTANLARGAIIVAKKKAIVKKLDAVQLLGAIDVLCSDKTGTLTEDHVTVASTCAPDGKICDTPVHLAYLNAKLQTSEFINNIDNAILSHVGDQALSTRLLEGKTKVADIPFDFYRRVVSVVYSDEQGDADKLHLVCKGAAEEVVRRCTHVRLSASSLDKIDVDACTARIDAIAERGERVIAVASRRVARSLLINGVATPELEAEMVLEGFVSILDPPKADAKNAIAQLRELGVQTKVLTGDALPTARRVCEIINLLPETPGASELCITGIELSQLGPVAFARAVEQKVVFAKLTPIQKLEVVRALRAQCHQVAFLGDGVNDGPALRGASCGISVNTGCDIAKDAADVILTQKNLDVIRDAVIVGRVSFVNTLKYIKMAASSNFGNVFSVTVAASWLPFLPMSPTQLLTQNLLYDISQASIPWDNVDEDMIRAPVSWSTKSMLKFMLCIGPLSSPFDILTFVVNWFYFGLRNANDAEQVARFQTHWFLEGCLTQVAIVHVLRTAKFPFVQSRASWQVCLTTALIAVISMVAPYLPFLRNALQMTLPDPMFYAFLFPYLVAYVLIVQVAKVVYLRFNRIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLG5</accession>
    <name>W3VLG5_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_03432</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000011">
        <property type="protein sequence ID" value="ETS62350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLG5"/>
    <dbReference type="HOGENOM" id="CLU_026859_3_2_1"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="12">
        <location>
            <begin position="100"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="543"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="652" mass="69595" checksum="070BAE0F0BBCB9C7" modified="2014-03-19" version="1">MSARITSGRSAEAAQCMEKDDRTAQLQCPTLGEESERERQRDRETGRETDRAACGSKCLTASAEVSITPTFFPFQPIHPTSLAPRSSLLAPTLHSRNMSRFVRPSKYRHVYPNVGKKEACYENVKVSNNAWDTNLIAANGKYLSINWNASGGGAFAVIPVSRSGKLPDIYPLCRGHTATVLDTAFSPFQDNFVASASDDGTIGLWKVDDAAFEQLDWSDKERERNGGVKDFEPLARVSAGGRKVGQVVWHPTASNVLAAATGDHVVKLFDVSHASTAASSPSISLRGFSDTIQSLDWDYTGTTLIATSRDRKIRTFDPRQGENPVQVADSHGGIKGARVVWCGDKQRAITTGFSKMSDRQMFLWDTANLAAGPLKQVTLDSSSGIIMPFWSDNNIVFLAGKGDGNIRYYELENDELHYLTESKSSEPQRGLTFVSRRFLNTDENEIAKAYKITGTTIQPVSFCVPRKAESFQSDIFPPAPSAVAALSAKDFFEGKRAPPNLISLETGKGVSSGASVPAATAAAAPTPVASAPAPSAAAAPVSTPARAASPVKSTPVRAASPVKSAPAPAPAAAPVETKSFGAVKHDSSAAAAAAGGANGSGSAGEVERLSTLVAQLRTQVEQRDTRIRHLEAENETLKTNQARAREALLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLH7</accession>
    <name>W3VLH7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PaG_04148</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="AWNI01000014">
        <property type="protein sequence ID" value="ETS61652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLH7"/>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_1"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000176">
        <property type="entry name" value="Isoleucine-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="34"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="710"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETS61652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="1091" mass="124488" checksum="7F9926E06A3F03C4" modified="2014-03-19" version="1">MADLTPKDPSDPAATFGEHDPTAAFSFPTEEEKVIRYWRAIDAFKTSLQQSKGRKPFSFYDGPPFATGLPHYGHLLAGTVKDIVTRHAHSTGHYVDRRFGWDCHGLPVEHEIDKRLNIRGKEDVMAMGVDKYNAECRSIVMTYQNEWRDTVERMGRWIDFDNGYKTMDINFMESVWWVFKTLHSKGLVYQGIRVMPYSTACTTPLSNFEAGLDYREVQDPAVTVSFPLLDDPTTAFLAWTTTPWTLPSNLGLCVHPDFNYIKIHDDERDTNFIIHEDLLTTLYKDPKKAKFQKLHTYKGKDLVGMQYQPIFPYFADRFQGRAFRVLSDTYVTSDAGTGIVHQAPAFGDDDHRVAIAHGVISRDESPPNPVDGSGRYTAEVPDYQGVHVKEADKQIQKDLKARGRLIVQATLTHQYPFCWRSGTPLIYKAIPSWFVRVEPAIEKLVKNNNATRWVPGHVGEGRFGNWIANARDWNVSRNRYWGTPIPLWASEDMEEIVCVGSVEELERLSGVSGINDLHKDKIDHITIPSQKGKGQLKRVEEVFDCWFESGSMPYAQAHYPFENKEQFEKSFPADFISEGLDQTRGWFYTLLILATHLFDSAPWKNLIVSGLVLAADGKKMSKSLRNYPDPNLLINQYGADAIRLYLINSPVVRAENLRFKEEGVKEVVSSTFLPWLNSFRFFLASVSLYEKDHGVKFVYDRHQSSTNVMDRWILARCQSLIRLISDEMAAYRLYTVVPRLGELIDELTNWYIRFNRRRLKGEYGVDDTKAALNSLFETLLTLCRTLSSFTPFLTENLYQGLRKYMPAPTADDKEDYRSVHFLSFPEVNESYFDPVIQRQFKALQAVVELGRVIRVNSNLPIRVPLKELVVFHTDAEYLADAESLADYIKEELNVRDLVLSSDEAKCGVRFKLFADWPVLGRKLRKDVGKVRKGLESVTSDEAKRYMQTGKLNVAGVDLVEGDLKVSRYVETKEIEGAFESNTDGNVVVLLDVQPRAELQAEGTAREVVNRIQRLRKKAGLVATDEVDAFYSFEQGLGQALAECIESQSDAFMKALRRKPLPESHKKPDAKVILQEEQEVGDDKFVLTLAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VLZ2</accession>
    <name>W3VLZ2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_03221</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VLZ2"/>
    <dbReference type="HOGENOM" id="CLU_023360_3_1_1"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="654" mass="69271" checksum="96489E604B594962" modified="2014-03-19" version="1">MTDAKPDAVNGKRPQPAAASASTLILLQISARALTFVLNQLLVRLVAPGIFGLANIQLELLLSTILFLSRDAIRTILIRNDRTRHASSVAASGAGPRSGTTNATHNVALLTIPIGFALTGIACGAYTALISPKSIHAVPTFHASIALYALGALSELVYEPLLIRAVRLGQPSLRVKAEGAAVFVKVLTTIATILCLPRWSTAPSTIKHVLADEKAVALLAFGIGQASFGMTMLAVHLSYFVTSYSFRQTLDLYIPRPDRVTRSDPRTGVASTETAWLDRATVSLCMAMAQQGVLKHLLTEADKFAVARYATLEDQGGYALASNYGSLVARILFQPVEETARIVFSSELVALDDESGASRPAPTGILRKAVEKAASMLAALFRLHLLLACIMITFGGPLSTAFLYIMAGPQWALGTSAPAILAAYTWYLPIMGINGIAEGFVQSVASRKQVKSYNRILLIASVGFVTVLASINYAVASRPSGNLGQAPGASSFLAKTGLVWANAISLSVRAGWCWAFLIKYFGLAESVIGQESKHDSTGSQAAIQHRVRPSAALPSRPAMVIFASVAGVLRVLVPKLMPTAAELLQTSNANEGASRTGRLQAIRLLLPTVGLSGVCLGAVLTSISVFERAALLKSLRSLGRRDASQSHADTCKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM07</accession>
    <name>W3VM07_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000013">
        <property type="protein sequence ID" value="ETS61771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM07"/>
    <dbReference type="HOGENOM" id="CLU_155991_4_1_1"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS61771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="89" mass="10165" checksum="B0AC4D5FD38F587A" modified="2014-03-19" version="1">MPVSFYDEIELEDMVYDEEKDLFHYPCPCGDRFEITRQQLKDAEDVARCPSCSLIIRVVFDPIDFEDDDDDEVPVNKIDTANTTVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W3VM57</accession>
    <name>W3VM57_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome maturation factor UMP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VM57"/>
    <dbReference type="HOGENOM" id="CLU_100687_1_0_1"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17483" checksum="D08410AC102CED1E" modified="2014-03-19" version="1">MSSTSNTQAEPSYALVPPKYASNTSTSSNASTWHPVYAGVHDTMRHGTANVLHQVSTASHHPVQNRLENWDATRDNLKLTMQRNVHGLGAPAHILMERKIASYNPAFDPTTSSNSISKVHLDILNGDDERIEPRDFLPSEISSTIPDMHSVMERRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMB3</accession>
    <name>W3VMB3_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_02446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMB3"/>
    <dbReference type="HOGENOM" id="CLU_486770_0_0_1"/>
    <dbReference type="OrthoDB" id="2549313at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS62709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="609" mass="67815" checksum="81CE9324F7FDC28D" modified="2014-03-19" version="1">MSGTASPSTHQSRLPAEILVDIIELAIFTSSPCPLVPPSVSRSSEEPTSPFDHPLRAAYTSAWAWTGHLLRVSKLFYSIARPLLLQTLTLDTDAAGKAFFTELAERNDPIETLKRVEKAWLGNLSALERNGLDVGPRSLKLSEAAWYEECPGGFVVGHAYASRTKPTTRRSKDLDRGRTKPKQYRSVSVYWAEEQLIEEVSDPDRSSSDDDSAESDEDAAFDMDEIPQGRSGRFSALSTPAEPTPLTEASSSSARQCSQGAGSVGDPRIDRPHEPAWQTLYSRQRRLSPVHSRGQPGPLAASLPSARIPQPLMAATAAGPSEDDLDPWDMQDAQERLAALATQPVDSSALHPVAADAPLGAATQSSPEISTTEDIAASTLAWCQASLQKQRRGREIYAYHVCTATLESWITPLFASLRSLRLITLSFYPGHILDDDKLEHMLRRILAENAKLERLLIRIVLDAASAGSRMRRFERTKTIAGAADRIGDERIRVMLLNPKVGEGELVALPEHRPEERVGTLDPLSRKAVTLTKEAWWSRVLQQNHCEREVEDVRCLEDDAMRLEKDREMRERRLWNWKMFFPPHQHGNPTHLVNLIHHADSWPDHPHPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMF9</accession>
    <name>W3VMF9_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PaG_03538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000012">
        <property type="protein sequence ID" value="ETS61987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMF9"/>
    <dbReference type="HOGENOM" id="CLU_045413_1_0_1"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="222"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETS61987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="420" mass="46126" checksum="F0978715EE720777" modified="2014-03-19" version="1">MAANTKGKVSQPATRHSAFHDLDDDDDDNDAARSTHRSSGRQEEIISFGRNGAQKRTSSPPRSAPPRVIPVASNLDWRQDRKQRMGIATNLKSLGPLVSMRRADSSVVSDPSQHHGTDNAADAINADAQKSGLEIRQPRTQQAVESHPAPSNSEETPAPAPDASVQGTDEEAIKALLAGDDGAAEVGAHLVIPQEDEAEFLQHDIESRPEAPSLDDYAATPIEQFGMALLRGMGWKEGMGAGKGGKGPQQAAEPKKRAALLGLGAKERAVPATGLPSSSSSHKNRASGKRDYKYVPITRADSPATSNTGPRSRHASRDDDKPRSHTSSHRDERRSDTSDRHAASRDGTRHTDSRSSRRRSRSPTARREDRHRGKARGEDDAARRFHAASSSSREHRRDRDRDDRDRHDKHRDDRHRDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMP4</accession>
    <name>W3VMP4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PaG_02484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMP4"/>
    <dbReference type="HOGENOM" id="CLU_098333_0_2_1"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETS62745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="194" mass="21261" checksum="A0E104E0469041D8" modified="2014-03-19" version="1">MNSRLTEANSSEASSSRTLTVEHPNASDTQPHDVGILRLRPEPRSRPGVDQTSSTAGASTRRVVWTEETVDNEGLGRKKSKICCIYHKPKAFDESSDESSSASDSSESNSDSDAASSDSDSGPALSKAAKEKLKQRTKHRHHHQHAEGCNHAKSRSSTTTITQQQPDQDQNARSAHEHEPADNFRPNAYERGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMU4</accession>
    <name>W3VMU4_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PaG_02550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMU4"/>
    <dbReference type="HOGENOM" id="CLU_362543_0_0_1"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="604"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETS62800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="694" mass="75749" checksum="0F3E5A18503AAF53" modified="2014-03-19" version="1">MPPAKCDVIPKEQFTPFAERRACAGCRKIKSRCIFPDDTASNACTRCIRLSIECVVPSHHRGVKLEGQRAKSTSAAPIRPAPKSHSRQSASPSPNDDTDGSASASTNPFSVQSLLDTTSSERTASKALLSSTFHSHIQEEPAVKVATASAGRPLIESVISAGLFDEDEVGELVRFYYDRLNPIIALLDSHIYSLKALKSSPDYRILLAAICTVSSKFIKVERYLDSLEFLKPALSRIAADDIPPQLEIIQSLSILAMWKHPKDGSSWRKVRLAITQAFELGLHELFAPQKRSKHGPSRSFIQSQRTIMQLSCFEDGYRDQRHLPPAIDPSLLPDPREWIESLGDMVQDIDVRLAASRENANIKRDLITSLKQSNARSPNPAQISRATCLRNARLIKMGITAQTCSSSIWMNPPASEIPCQHSGRPCLLFHDTNTLFNYHRALYSIYSSPLLSGPGFAQDRQAAFQKCSELSVQLFELLNGPYGQAGYYRYELAIQACSAIRQAADATSPSLEDPLEQGSYLARFLRFCCKKLPSTISINENSPVNAEDLVISEDAKWAMGLNPFTQLSSAVGVPAQFRAPYAGGTSPRNGGASMSRYTGQHLYHSNASQTSGSPSLLSTSSPQNGQYGPAAGEANFVFHGHSNAAGQHGTPAAGGSTMQYLSESLVPPAYPMNWDTYDDNSIITFLQSISNGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W3VMX2</accession>
    <name>W3VMX2_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VMX2"/>
    <dbReference type="HOGENOM" id="CLU_075895_0_0_1"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35496" checksum="A6D2B8BA1E9F29F9" modified="2014-03-19" version="1">MPTATAAAMNDRRHADADERSSLLPTLNDHRVKDAGPSRWTRWTSVLKEHAWTPLPHFDSSDALPTSYVVPLLLQCVITGLADASTFSLTGTWVGFMTGNMVQMVINAFDFWLPSSSNASNDQDRVRTKLMYNLSAIGGFMLGCQVTALILKRFTSERSKRMALVAFSLYRSVMTFGLVMFGAQHSTLQLQGPLGWLVHSILAASMGCQSTYSTSLATPFSNTVVFTATLTAVSSDLHLHNLRLEKAKRFKLLSIVGLLSGGALSQAVLKLATKASRRSKHEAVQHALMLLSAMELLLGLSWFLCGIAASSKQYARRRAAHLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP52</accession>
    <name>W3VP52_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PaG_03203</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP52"/>
    <dbReference type="HOGENOM" id="CLU_008296_1_0_1"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="330"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETS62566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="883" mass="95894" checksum="4CAE022C8DE2BE43" modified="2014-03-19" version="1">MDANQLLTNTLSPDQAIRTDAEQKLEAAARDSYPVYMSTLAAELANESSPSHIRTAAGLAVKNALTARDPTRVEEYTARWTLLPQAGRDEIKQKVLSTLGSQEHRAGTAAAQVIAAIAAIELPVGLWNELIAQLLGAMGDASNMRLRQAALQAIGFTCEGISSDVLAAQSNEILTAVIQGARKEEPSPEVQLAALQALYNSLEFALYNSLEFVRANFEREGERNYIMQVVCEATQSPNIAVKIAAYECLVRTMQLYYDKMRFYMEQALFGLTVLGMRDSEPKVALQAVEFWSTVCDEEIELALEAEEAAEFGEDPERACYNFARIALPEIVPVLLELLKTQDEDADEDEWDVSKAAGTCVGLLAQVVGDDIVRLAVPFVEGNIKNPDWHAREAAVMCFGSIMEGPDRKTLAPLVESALPTIIEMLRDQSIAVKDTAAWTLGRISDLCCDSIKTDVHLPALVQALVLGLQDEPRIVTNCCWAIMNLSEQLGANALSYETGGDAAAVPSTPLSPFFEGIVGSLLQATGRNSNESNSRTSAYEALASAVTHCAADCVHQASGVLVQILDRQQQLNEVAAQLVGMDDRNNWAELQGNLCSVLMACVRRLGRETLALGDRIMTNLLTLIQNGAKQPTVLEDAFFTVGAVISAFEADFEKYLGAFLPFMVEGLRNHEEYQLCSISVGLIGDICRALGENSAKYCDDFMNALFANLQSPQLNRSVKPPILSCFGDIAMAIGAAFEKYLQMGMSVLQQASLIQTVDPNDYDMIDYINSLREGICEAYVGTVSGMRAGNRIEALQPYVEGMFAFIALVAQAQTQSQASEPLIRATLGLLGDLASAFPNGQLKVLLTAPWVAEFVKAGRGRGNGSETRKTAAWAREMVKKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP61</accession>
    <name>W3VP61_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PaG_01530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP61"/>
    <dbReference type="HOGENOM" id="CLU_013985_42_1_1"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETS63255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="351" mass="38186" checksum="40C731536F8F400A" modified="2014-03-19" version="1">MSEGATSRDRKGGRASDDVTSRVSVLGRRSLRVGLWQAERGKVQEEIAAGSGLAIADVDKPRCPLEDTMAYGHVPRPAGSDPSTLRPRLYSLPERAQSDERQAIVTLAFNAQGVDQHSYLHAQRGDKRTLRPPQALVEYLAGVFNDELERGVSYPQRGPMPLAEFEGYFLGYDLIVGFFVSARRLTALSPDATIPEDGLEARSLSELPDLAKLDYTAQVAGFYYIKPNYPGRSSHLCNAGFVVPPAGRGLGLGGVLGRSFLHYAPLAGYKGSVFNLVYVNNMASVRIWQRLGFTIVGRLPMAGALRTEDGREELTDAYIIFKDFTGTVQARGDAEPKPLPIQAQDGTKGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W3VP87</accession>
    <name>W3VP87_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-carboxy extension protein fusion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PaG_03229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000010">
        <property type="protein sequence ID" value="ETS62592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VP87"/>
    <dbReference type="HOGENOM" id="CLU_010412_3_4_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETS62592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="113" mass="12902" checksum="F424BC6208D88B88" modified="2014-03-19" version="1">MQIFVKTLTGKTITLEVESSDTIDNQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKVLAGKYNCDKQICRKCYARLPPRATNCRKRKCGHSSQLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPQ1</accession>
    <name>W3VPQ1_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPQ1"/>
    <dbReference type="HOGENOM" id="CLU_009729_0_0_1"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETS62722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="75290" checksum="63CD6358D3D702C6" modified="2014-03-19" version="1">MASGSSAASIAQERDTHSEPINFRAALAAFEQNSSTHAGSPGAAAGRTPQTPARPSGGLDPIARSASTPHNRAGAASNNPFSAANAAASPRVATGSIPATSASGMLSAPSPAVVASTSPSYATGSTLRKSDSGLSLRELMNKSLPRSAHSPVPPSRSRSGADDDSTAAAASASASGRSTPAMAPRAIVGLFAEDPSADALRRTASPASSLYSDERAARHMLDTSLDEQDHTHPMFAHAVMPRSTPGSPERKGSTSSTASASSTTPRLPPRPTQPSLAPSPTLTEFGQLQPAAKDKAVGYATYTPGFKRGVATIEVQRTPPALPPRSATLGQSERGKSREPPSVPKKPLKPAPPPRPTAAPRSTPDSAAKAFRFGSAAAESTCAQPAPPPRPYKPSAPGGTSLTPTPPNTATTAKHRKSGSNVFTSISLSDEASSELRRTLETDVRADVQLPPPARGRPPTTPHRTATASTATGGVVSSLIGTAASALPLFKASTPLAAGARSLADGAPSKQYGLSRSGSMHSDLSVLPGHADAGSWMPTRAVQLADAPKRAPAAAVPGWWKMPDPSARARYDALFTTTLADQARRRKHARADESASNASTLREKPRTAGVQALRGWFESDAPPAADTHTGVQADELGAASVRRVWKRSRLPARFLAQVWDYAVQLGDDAKPPSPALGREAFVCALATIDAELARRRSRRQQRTAQASDAHAVAARETGGRRVPPPPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPR7</accession>
    <name>W3VPR7_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PaG_01776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000008">
        <property type="protein sequence ID" value="ETS63490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPR7"/>
    <dbReference type="HOGENOM" id="CLU_514953_0_0_1"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="97"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETS63490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="515" mass="54479" checksum="9E5C097F430A36CF" modified="2014-03-19" version="1">MSPSETPASLADTQPPRAKQAANEQKAADNRARAQQNRERAANNRTQKPSASDQDGQHPAPKAPPTSASAQPSKKPARRDAAKPAATRQAKASTHFKSKVVIRRLPPNLPEAVFWKAVSPWIRDAADCQPPASDSLTSASGEASASTSSASALTPTVDFKQFIPGKLKTDASKQNKHARAYVRFLDANALVLFHKHFDGHIFRDSKARETVAIVEFAPYQKVVPARGRRSKPDPKQGTIETDADYLAFVERLSKAGEDDKRAEGDLLASTYDPRERAREREAAAAAGKSTPLLEHLRAVKQAKLESAALAKKAKKAERAAAKAAARSADGAAATATQPAEPANKKAKKGKRHRTKEKLAAIDAAHVGGGKEIEAASKEPSKREKKGRQRKGKGRADGVDANAANTDTAPRATTKPESAKKQGNPAKDAPNTATATPARNPKQAGGRPAKKKPDVKAPAAEDNADAGVAEGDGSTRKKPPRRKGGAKASTKPPSASTATAPASQPKLQILKREPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W3VPS7</accession>
    <name>W3VPS7_MOEAP</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase fuz7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PaG_02491</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VPS7"/>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="106"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETS62752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019462"/>
        </source>
    </evidence>
    <sequence length="444" mass="47510" checksum="25ED0832597DE3BA" modified="2014-03-19" version="1">MLSSGAGSSIRKKRNFKGLQLAESPLASPAGAASTPNNGESSAASNASTIGKSATVTPGGSLALPGRNGAEAEPNSGANYHNKLTQQLANLELGVEYKLDLKNEDLKTVSELGAGNGGTVTKVLHEKSGTVMAKKVVFIDAKPSVRKQILRELQILHECNSPYIVSFYGAYLSEPHICMCMEFMDKDSLDGIYKKHGPIPPEICGKIAVVVVHGLTYLYDVHRIIHRDVKPSNILVNGKGQIKICDFGVSGELINSIADTFVGTSTYMSPERIQGDQYSVKSDVWSLGVSVIEVALGHFPFANNDDESDSGSDSDADLERANALVQEDLGGTLSPTKPAPKLPVAAAAAAAQKQSRRKSKAAGVSLEGSSHQMSILDLLQHIVNEPPPKLPEGRFPKLMEEFVQLCLVKDPARRPTPKDLTKHAYVMEADAAKVDLQAWVDGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W3VQ30</accession>
    <name>W3VQ30_MOEAP</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PaG_02642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Moesziomyces aphidis</name>
        <name type="synonym">Pseudozyma aphidis</name>
        <dbReference type="NCBI Taxonomy" id="84754"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Ustilaginomycotina</taxon>
            <taxon>Ustilaginomycetes</taxon>
            <taxon>Ustilaginales</taxon>
            <taxon>Ustilaginaceae</taxon>
            <taxon>Moesziomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Genome Announc." volume="2" first="E0005314" last="E0005314">
            <title>Genome sequence of the basidiomycetous fungus Pseudozyma aphidis DSM70725, an efficient producer of biosurfactant mannosylerythritol lipids.</title>
            <authorList>
                <person name="Lorenz S."/>
                <person name="Guenther M."/>
                <person name="Grumaz C."/>
                <person name="Rupp S."/>
                <person name="Zibek S."/>
                <person name="Sohn K."/>
            </authorList>
            <dbReference type="PubMed" id="24526638"/>
            <dbReference type="DOI" id="10.1128/genomeA.00053-14"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 32657 / CBS 517.83 / DSM 70725 / JCM 10318 / NBRC 10182 / NRRL Y-7954 / St-0401</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AWNI01000009">
        <property type="protein sequence ID" value="ETS62882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W3VQ30"/>
    <dbReference type="HOGENOM" id="CLU_278123_0_0_1"/>
    <dbReference type="OrthoDB" id="3353673at2759"/>
    <dbReference type="Proteomes" id="UP000019462">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <featur
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